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MASM7 Mitochondrial Metabolism activator

Name: MASM7
Brand: Selleck Chemicals
SKU: E5826
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E5826

MASM7 is an activator of mitofusins that promotes mitochondrial fusion through mitofusins. It increases mitochondrial AR in MEFs in a concentration-dependent manner, with an EC50 value of 75 nM. This compound also directly binds to the HR2 domain of MFN2 with a dissociation constant (Kd) of 1.1 μM, effectively activating MFN2 or MFN to induce fusion.

Chemical Structure

Molecular Weight: 453.58

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Quality Control

Batch: E582601 DMSO]50 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.46%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.46

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Drug Metabolite
Other Mitochondrial Metabolism Inhibitors	Mitochondrial Fusion Promoter M1 CTPI-2 D-Carnitine hydrochloride NL-1 Ninerafaxstat trihydrochloride MFI8 4-Pentenoic acid ER-000444793 Emapunil (AC 5216) Olesoxime (TRO 19622)

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (110.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	453.58	Formula	C₂₂H₂₃N₅O₂S₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	920868-45-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/35798717/

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