Home PI3K/Akt/mTOR AMPK activator MK-8722 For research use only.

MK-8722

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

MK-8722 Chemical Structure

MK-8722 Chemical Structure

CAS: 1394371-71-1

Purity & Quality Control

Batch: E103101 DMSO] 90 mg/mL] false] Ethanol] 2 mg/mL] false] Water] Insoluble] false Purity: 99.43%
99.43

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Signaling Pathway

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AMPK Signaling Pathway

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Biological Activity

Description

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
Targets
pan-AMPK [1]
In vitro
In vitro

MK-8722 activates pAMPK complexes with increased potency and magnitude versus AMP. In primary mouse hepatocytes, HepG2 cells, or primary human myocytes, MK-8722 results in the phosphorylation of a number of additional known targets of pAMPK, and the most potent off-target activity observed for MK8722 is against the serotonin 5-HT2A receptor.[1]
In Vivo
In vivo

Pharmacological pan-AMPK activation by MK-8722 leads to chronically sustainable improvements in glucose homeostasis, including the amelioration of insulin resistance and hyperglycemia. Acute treatment with MK-8722 (30 mpk) significantly suppress blood glucose and insulin levels. In mice, chronic MK-8722 dose also increases muscle Glut4 protein levels. In rhesus monkeys, MK8722 results in cardiac hypertrophy associated with increased cardiac and skeletal muscle glycogen.[1]
Animal Research Animal Models Mouse, Rat, Rhesus monkeys
Dosages 30 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 449.89 Formula

C24H20ClN3O4
CAS No. 1394371-71-1 SDF --
Smiles OC1COC2C(COC12)OC3=NC4=NC(=C(Cl)C=C4[NH]3)C5=CC=C(C=C5)C6=CC=CC=C6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 90 mg/mL ( (200.04 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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