Home PI3K/Akt/mTOR AMPK activator MK-8722

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MK-8722 AMPK activator

Cat.No.E1031

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

MK-8722 AMPK activator Chemical Structure

Chemical Structure

Molecular Weight: 449.89

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Quality Control

Batch: E103101 DMSO]90 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.43%
99.43

Solubility

In vitro
Batch:

DMSO : 90 mg/mL (200.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 449.89 Formula

C24H20ClN3O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1394371-71-1 -- Storage of Stock Solutions

Synonyms N/A Smiles OC1COC2C(COC12)OC3=NC4=NC(=C(Cl)C=C4[NH]3)C5=CC=C(C=C5)C6=CC=CC=C6

Mechanism of Action

Targets/IC50/Ki
pan-AMPK
In vitro

MK-8722 activates pAMPK complexes with increased potency and magnitude versus AMP. In primary mouse hepatocytes, HepG2 cells, or primary human myocytes, this compound results in the phosphorylation of a number of additional known targets of pAMPK, and the most potent off-target activity observed for it is against the serotonin 5-HT2A receptor.
In vivo

Pharmacological pan-AMPK activation by MK-8722 leads to chronically sustainable improvements in glucose homeostasis, including the amelioration of insulin resistance and hyperglycemia. Acute treatment with this compound (30 mpk) significantly suppress blood glucose and insulin levels. In mice, chronic administration of this chemical also increases muscle Glut4 protein levels. In rhesus monkeys, it results in cardiac hypertrophy associated with increased cardiac and skeletal muscle glycogen.
References

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