Catalog No.E1031

For research use only.

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

MK-8722 Chemical Structure

CAS No. 1394371-71-1

Purity & Quality Control

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Biological Activity


MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

pan-AMPK [1]
In vitro

MK-8722 activates pAMPK complexes with increased potency and magnitude versus AMP. In primary mouse hepatocytes, HepG2 cells, or primary human myocytes, MK-8722 results in the phosphorylation of a number of additional known targets of pAMPK, and the most potent off-target activity observed for MK8722 is against the serotonin 5-HT2A receptor.[1]

In vivo

Pharmacological pan-AMPK activation by MK-8722 leads to chronically sustainable improvements in glucose homeostasis, including the amelioration of insulin resistance and hyperglycemia. Acute treatment with MK-8722 (30 mpk) significantly suppress blood glucose and insulin levels. In mice, chronic MK-8722 dose also increases muscle Glut4 protein levels. In rhesus monkeys, MK8722 results in cardiac hypertrophy associated with increased cardiac and skeletal muscle glycogen.[1]

Protocol (from reference)

Animal Research:


  • Animal Models: Mouse, Rat, Rhesus monkeys
  • Dosages: 30 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 449.89


CAS No. 1394371-71-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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