MK-8722

Catalog No.E1031

For research use only.

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

MK-8722 Chemical Structure

CAS No. 1394371-71-1

Purity & Quality Control

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Biological Activity

Description

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

Targets
pan-AMPK [1]
In vitro

MK-8722 activates pAMPK complexes with increased potency and magnitude versus AMP. In primary mouse hepatocytes, HepG2 cells, or primary human myocytes, MK-8722 results in the phosphorylation of a number of additional known targets of pAMPK, and the most potent off-target activity observed for MK8722 is against the serotonin 5-HT2A receptor.[1]

In vivo

Pharmacological pan-AMPK activation by MK-8722 leads to chronically sustainable improvements in glucose homeostasis, including the amelioration of insulin resistance and hyperglycemia. Acute treatment with MK-8722 (30 mpk) significantly suppress blood glucose and insulin levels. In mice, chronic MK-8722 dose also increases muscle Glut4 protein levels. In rhesus monkeys, MK8722 results in cardiac hypertrophy associated with increased cardiac and skeletal muscle glycogen.[1]

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Mouse, Rat, Rhesus monkeys
  • Dosages: 30 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 449.89
Formula

C24H20ClN3O4

CAS No. 1394371-71-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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