Mianserin HCl

Catalog No.S1382 Synonyms: ORG GB-94 HCl

For research use only.

Mianserin (ORG GB-94) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.

Mianserin HCl Chemical Structure

CAS No. 21535-47-7

Selleck's Mianserin HCl has been cited by 1 Publication

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Biological Activity

Description Mianserin (ORG GB-94) is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.
Targets
Histamine receptor [1]
In vitro

Mianserin (2 mg/kg s.c.) causes a modest increase of DOPAC levels up to about 30% above base-line, which is statistically significant when compared to saline. Mianserin increases extracellular norepinephnne, but a comparison with desipramine and idazoxan showed that both NE reuptake inhibition and alpha-2 autoreceptor blockade contributed to the mianserin-induced increase in extracellular norepinephnne. [1] Mianserin and eltoprazine displays opposite effects in the elevated plus-maze: Mianserin induces anxiolytic-like effects, while eltoprazine shows anxiogenic-like ones. Mianserin treatment induces a decrease in the number of these sites, while eltoprazine treatment results in an increase. [2]

In vivo Mianserin, which has a small or no effect in noradrenaline (NA) reuptake but may enhance release by blocking presynaptic inhibition mediated by alpha 2-adrenoceptors, induced regeneration of catecholamine fibers in the rat cerebral cortex. [3] Mianserin attenuates the effects of both m-CPP and SKF 38393 in neonatal 6-OHDA-lesioned rats, suggesting that DA agonist effects are mediated by 5-HT neurochemical systems. [4] Mianserin (10 mg/kg, SC) dose-dependently increases up to about 6 times extracellular dopamine in the medial prefrontal cortex of the rat. Mianserin also dose-dependently increases extracellular noradrenaline in the prefrontal cortex. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 60 mg/mL
(199.44 mM)
Water 30 mg/mL
(99.72 mM)
Ethanol 21 mg/mL
(69.8 mM)

Chemical Information

Molecular Weight 300.83
Formula

C18H20N2·HCl

CAS No. 21535-47-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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