Mupirocin

Catalog No.S4297

For research use only.

Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.

Mupirocin Chemical Structure

CAS No. 12650-69-0

Selleck's Mupirocin has been cited by 4 Publications

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

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Biological Activity

Description Mupirocin is an isoleucyl t-RNA synthetase inhibitor, used in the treatment of bacterial skin infections.
Targets
isoleucyl t-RNA synthetase [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL warmed
(199.75 mM)
Ethanol 100 mg/mL
(199.75 mM)
Water 46 mg/mL warmed
(91.88 mM)

Chemical Information

Molecular Weight 500.62
Formula

C26H44O9

CAS No. 12650-69-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C1C(O1)CC2COC(C(C2O)O)CC(=CC(=O)OCCCCCCCCC(=O)O)C)C(C)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03685487 Completed Procedure: decolonization|Other: compliance questionnaire Staphylococcus Aureus Centre Hospitalier Universitaire de Saint Etienne February 12 2019 --
NCT02967432 Completed Drug: Mupirocin Topical Ointment|Drug: Petroleum Jelly Staphylococcus Crouse Hospital|Jana Shaw MD|Steven Gross MD|David Martin RN|Dale Franz RPh|Rachel Carey October 2016 Phase 2
NCT02045329 Terminated -- Nasal Colonization With Staph Aureus VA Eastern Colorado Health Care System October 2013 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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