Meclofenamate Sodium

Catalog No.S4295

For research use only.

Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.

Meclofenamate Sodium Chemical Structure

CAS No. 6385-02-0

Selleck's Meclofenamate Sodium has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
Targets
COX-1 [1] COX-2 [1]
40 nM 50 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 63 mg/mL
(198.03 mM)
Water 63 mg/mL
(198.03 mM)
Ethanol '''63 mg/mL

Chemical Information

Molecular Weight 318.13
Formula

C14H11Cl2NO2.Na

CAS No. 6385-02-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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