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Midodrine

Name: Midodrine
Brand: Selleck Chemicals
SKU: S5735
Rating: 5 (1 reviews)

Catalog No.S5735 Purity: 98%

Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.

Midodrine Chemical Structure

CAS: 42794-76-3

Purity & Quality Control

Batch: S573501 DMSO] 51 mg/mL] false] ] ] false] ] ] false Purity: 98%

Midodrine Related Products

Related Targets	α-adrenergic receptor β-adrenergic receptor Beta-Adrenergic Receptor	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library	Click to Expand

Signaling Pathway

Adrenergic Receptor Signaling Pathway

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description	Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05240391	Completed	Paracentesis-Induced Circulatory Dysfunction	Asian Institute of Gastroenterology India	February 20 2021	Phase 3
NCT04455464	Completed	Chronic Liver Disease	Institute of Liver and Biliary Sciences India	July 11 2020	Not Applicable
NCT03911817	Completed	Septic Shock	Ain Shams University	November 15 2017	Phase 4
NCT02771158	Withdrawn	Hypotension\|Shock Septic\|Sepsis	Northwell Health	August 2017	Phase 4

Chemical Information & Solubility

Molecular Weight	254.28	Formula	C₁₂H₁₈N₂O₄
CAS No.	42794-76-3	SDF	--
Smiles	COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 51 mg/mL ( (200.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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