For research use only.
Catalog No.S1381 Synonyms: SM 7338
CAS No. 96036-03-2
Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.
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|Description||Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.|
Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae.  Meropenem is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Meropenem MICs are not significantly influenced by high inocula and the drug is generally bactericidal. Meropenem demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases.  Meropenem binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus.  Meropenem is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. Meropenem has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity. 
|In vivo||Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. Meropenem significantly increases the urinary excretion of valproate- glucuronide in rabbits. |
-  Edwards JR, et al. J Antimicrob Chemother, 1995, 36 Suppl A, 1-17.
-  Jones RN, et al. J Antimicrob Chemother, 1989, 24 Suppl A, 9-29.
-  Yang Y et al. J Antimicrob Chemother, 1995, 35(1), 75-84.
|In vitro||DMSO||76 mg/mL (198.19 mM)|
|Water||8 mg/mL (20.86 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04809259||Not yet recruiting||Device: Isothermal pouch||Infection Bacterial||University of Lausanne Hospitals||May 1 2021||Phase 1|
|NCT04257838||Not yet recruiting||Drug: Piperacillin/tazobactam or Meropenem||Sepsis|Septic Shock||Fundación Pública Andaluza para la gestión de la Investigación en Sevilla||February 15 2020||--|
|NCT04489459||Recruiting||Drug: Colistin|Drug: Meropenem|Drug: Tigecycline||Treatment of Blood Stream Infections Due to Multidrug-Resistant Klebsiella Pneumoniae||Al-Azhar University||September 21 2019||Phase 4|
|NCT04042662||Not yet recruiting||Other: no intervention||Predictors and Outcomes of Meropenem Treatment Failure||Universiti Sains Malaysia||August 5 2019||--|
|NCT03571711||Recruiting||Drug: Meropenem Injection||Peritonitis Bacterial|Liver Cirrhosis||Hannover Medical School||June 28 2018||--|
|NCT03507751||Unknown status||Drug: Meropenem|Procedure: CRRT||Infection|Renal Failure||Medical University of Lublin|University of Warmia and Mazury in Olsztyn||April 2 2018||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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