Meropenem

Catalog No.S1381 Synonyms: SM 7338

Meropenem Chemical Structure

Molecular Weight(MW): 383.46

Meropenem is an ultra-broad spectrum injectable antibiotic.

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Biological Activity

Description Meropenem is an ultra-broad spectrum injectable antibiotic.
In vitro

Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae. [1] Meropenem is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Meropenem MICs are not significantly influenced by high inocula and the drug is generally bactericidal. Meropenem demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases. [2] Meropenem binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus. [3] Meropenem is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. Meropenem has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity. [4]

In vivo Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. Meropenem significantly increases the urinary excretion of valproate- glucuronide in rabbits. [5]

Protocol

Solubility (25°C)

In vitro DMSO 76 mg/mL (198.19 mM)
Water 8 mg/mL (20.86 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 383.46
Formula

C17H25N3O5S

CAS No. 96036-03-2
Storage powder
in solvent
Synonyms SM 7338

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04042662 Not yet recruiting Other: no intervention Predictors and Outcomes of Meropenem Treatment Failure University of Science Malaysia August 5 2019 --
NCT03915236 Recruiting Device: MON4STRAT Strategy|Other: Control group Lower Respiratory Tract Infection Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal February 18 2019 Not Applicable
NCT03006679 Withdrawn Drug: Meropenem-Vaborbactam|Drug: Piperacillin/Tazobactam Hospital-Acquired Bacterial Pneumonia|Ventilator-Associated Bacterial Pneumonia|Hospital-Acquired Pneumonia|Ventilator-Associated Pneumonia Melinta Therapeutics Inc. August 2018 Phase 3
NCT03571711 Recruiting Drug: Meropenem Injection Peritonitis Bacterial|Liver Cirrhosis Hannover Medical School June 28 2018 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID