Meropenem

Catalog No.S1381 Synonyms: SM 7338

For research use only.

Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.

Meropenem Chemical Structure

CAS No. 96036-03-2

Purity & Quality Control

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Biological Activity

Description Meropenem (SM 7338) is an ultra-broad spectrum injectable antibiotic.
In vitro

Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae. [1] Meropenem is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Meropenem MICs are not significantly influenced by high inocula and the drug is generally bactericidal. Meropenem demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases. [2] Meropenem binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus. [3] Meropenem is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. Meropenem has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity. [4]

In vivo Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. Meropenem significantly increases the urinary excretion of valproate- glucuronide in rabbits. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 383.46
Formula

C17H25N3O5S

CAS No. 96036-03-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04276480 Not yet recruiting Drug: Piperacillin-tazobactam Enterobacteriaceae Infections University Hospital Bordeaux July 2021 Not Applicable
NCT04809259 Not yet recruiting Device: Isothermal pouch Infection Bacterial University of Lausanne Hospitals May 1 2021 Phase 1
NCT04876430 Recruiting Drug: Meropenem Carbapenem-Resistant Enterobacteriaceae Infection|Bloodstream Infection Hospital de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico e Tecnológico May 4 2021 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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