Meropenem

Catalog No.S1381 Synonyms: SM 7338

Meropenem Chemical Structure

Molecular Weight(MW): 383.46

Meropenem is an ultra-broad spectrum injectable antibiotic.

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Choose Selective Anti-infection Inhibitors

Biological Activity

Description Meropenem is an ultra-broad spectrum injectable antibiotic.
In vitro

Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae. [1] Meropenem is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Meropenem MICs are not significantly influenced by high inocula and the drug is generally bactericidal. Meropenem demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases. [2] Meropenem binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus. [3] Meropenem is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. Meropenem has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity. [4]

In vivo Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. Meropenem significantly increases the urinary excretion of valproate- glucuronide in rabbits. [5]

Protocol

Solubility (25°C)

In vitro DMSO 76 mg/mL (198.19 mM)
Water 8 mg/mL (20.86 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 383.46
Formula

C17H25N3O5S

CAS No. 96036-03-2
Storage powder
in solvent
Synonyms SM 7338

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03630081 Not yet recruiting Complicated Urinary Tract Infection|Acute Pyelonephritis Wockhardt|Medpace Finland OY August 25 2019 Phase 3
NCT03630081 Not yet recruiting Complicated Urinary Tract Infection|Acute Pyelonephritis Wockhardt|Medpace Finland OY August 25 2019 Phase 3
NCT03840148 Not yet recruiting Urinary Tract Infections|Acute Pyelonephritis VenatoRx Pharmaceuticals Inc. April 2019 Phase 3
NCT03671967 Not yet recruiting Beta Lactam Resistant Bacterial Infection|Enterobacteriaceae Infections|Bacteremia Rambam Health Care Campus|Rabin Medical Center|The Baruch Padeh Medical Center Poriya|Emek Medical Center|University of Modena and Reggio Emilia|Tel Aviv Medical Center|Meir Medical Center|Soroka University Medical Center|Laniado Hospital|The Chaim Sheba Medical Center|Hadassah Medical Organization|Università di Pisa Cisanello Hospital|Universita di Verona|Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi|University of Milan|Istituti Ospitalieri di Cremona|Hospital Universitario Virgen Macarena|McGill University Health Center|Jewish General Hospital April 2019 Phase 4
NCT03671967 Not yet recruiting Beta Lactam Resistant Bacterial Infection|Enterobacteriaceae Infections|Bacteremia Rambam Health Care Campus|Rabin Medical Center|The Baruch Padeh Medical Center Poriya|Emek Medical Center|University of Modena and Reggio Emilia|Tel Aviv Medical Center|Meir Medical Center|Soroka University Medical Center|Laniado Hospital|The Chaim Sheba Medical Center|Hadassah Medical Organization|Università di Pisa Cisanello Hospital|Universita di Verona|Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi|University of Milan|Istituti Ospitalieri di Cremona|Hospital Universitario Virgen Macarena|McGill University Health Center|Jewish General Hospital April 2019 Phase 4
NCT03840148 Not yet recruiting Urinary Tract Infections|Acute Pyelonephritis VenatoRx Pharmaceuticals Inc. April 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID