Catalog No.S1381 Synonyms: SM 7338
Molecular Weight(MW): 383.46
Meropenem is an ultra-broad spectrum injectable antibiotic.
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|Description||Meropenem is an ultra-broad spectrum injectable antibiotic.|
Meropenem has an antibacterial spectrum which is broadly similar to that of imipenem but, whilst slightly less active against staphylococci and enterococci, it is more active against Pseudomonas aeruginosa, all Enterobacteriaceae and Haemophilus influenzae.  Meropenem is two- to four-fold more active than imipenem against Gram-negative organisms and its spectrum of antimicrobial activity is wider than those of all other drugs tested. Meropenem MICs are not significantly influenced by high inocula and the drug is generally bactericidal. Meropenem demonstrates antagonism with several other beta-lactams against strains producing Type I cephalosporinases.  Meropenem binds most strongly to penicillin-binding protein 2 of Escherichia coli and Pseudomonas aeruginosa, and to penicillin-binding proteins 1 of Staphylococcus aureus.  Meropenem is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. Meropenem has one identified metabolite, a beta-lactam ring-opened form which is devoid of microbiological activity. 
|In vivo||Meropenem significantly increases the plamsa total clearance of valproate to about 1.5 times the control (6.09 mL/min/kg vs. 4.28 mL/min/kg) in rabbits. Meropenem significantly increases the urinary excretion of valproate- glucuronide in rabbits. |
-  Edwards JR, et al. J Antimicrob Chemother, 1995, 36 Suppl A, 1-17.
-  Jones RN, et al. J Antimicrob Chemother, 1989, 24 Suppl A, 9-29.
-  Yang Y et al. J Antimicrob Chemother, 1995, 35(1), 75-84.
|In vitro||DMSO||76 mg/mL (198.19 mM)|
|Water||8 mg/mL (20.86 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04042662||Not yet recruiting||Other: no intervention||Predictors and Outcomes of Meropenem Treatment Failure||University of Science Malaysia||August 5 2019||--|
|NCT03915236||Recruiting||Device: MON4STRAT Strategy|Other: Control group||Lower Respiratory Tract Infection||Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal||February 18 2019||Not Applicable|
|NCT03006679||Withdrawn||Drug: Meropenem-Vaborbactam|Drug: Piperacillin/Tazobactam||Hospital-Acquired Bacterial Pneumonia|Ventilator-Associated Bacterial Pneumonia|Hospital-Acquired Pneumonia|Ventilator-Associated Pneumonia||Melinta Therapeutics Inc.||August 2018||Phase 3|
|NCT03571711||Recruiting||Drug: Meropenem Injection||Peritonitis Bacterial|Liver Cirrhosis||Hannover Medical School||June 28 2018||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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