Maprotiline HCl

Catalog No.S2517

For research use only.

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.

Maprotiline HCl Chemical Structure

CAS No. 10347-81-6

Selleck's Maprotiline HCl has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
Adrenergic Receptor [1]
In vitro

Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3]

In vivo

Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 313.86


CAS No. 10347-81-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04200066 Not yet recruiting Drug: Temozolomide Tamoxifen Maprotiline Glioblastoma|Brain Tumor University of Rochester June 1 2022 Phase 1

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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