Home Transmembrane Transporters CD markers inhibitor MK-0159

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MK-0159 CD markers inhibitor

Cat.No.E1276

MK-0159 (Compound 37) is an inhibitor of CD38. This compound inhibits human, mouse, and rat CD38 (cell-free assays) with IC50 values of 22, 3, and 70 nM, respectively. It increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart.
MK-0159 CD markers inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 400.5

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Quality Control

Batch: E127601 DMSO]80 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.02%
99.02

Solubility

In vitro
Batch:

DMSO : 80 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 400.5 Formula

C20H24N4O3S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2641484-61-7 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
mCD38
3 nM
hCD38
22 nM
rcd38
70 nM
References

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