research use only

Mebendazole Parasite inhibitor

Name: Mebendazole
Brand: Selleck Chemicals
SKU: S4610
Availability: InStock
Rating: 5 (8 reviews)

Cat.No.S4610

Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. This compound interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.

Chemical Structure

Molecular Weight: 295.29

Jump to

Quality Control

Batch: Purity: 99.99%

99.99

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Reverse Transcriptase HIV HCV Protease
Other Parasite Inhibitors	Diminazene Aceturate Oxfendazole Oxibendazole (+/-)-nerolidol Emodepside Avermectin B1 Milbemycin Oxime Arteether Eprinomectin Diclazuril

Solubility

In vitro
Batch:

DMSO : 8 mg/mL (27.09 mM) Warmed with 60°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

DMSO : 6 mg/mL (20.31 mM) Warmed with 60°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.260mg/ml (0.88mM)	Taking the 1 mL working solution as an example, add 50 μL of 5.2 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.260mg/ml (0.88mM)	Taking the 1 mL working solution as an example, add 50 μL of 5.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	295.29	Formula	C₁₆H₁₃N₃O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	31431-39-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Mebenvet			SMILES	COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

In vitro	mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. This compound arrests cells at the G2-M phase before the onset of apoptosis. Its treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, this chemical appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells.
In vivo	When administered p.o. to nu/nu mice, Mebendazole strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. This compound treatment significantly reduces vessel densities in mice compared with those in control mice.
References	[1] https://pubmed.ncbi.nlm.nih.gov/25773183/ [2] https://pubmed.ncbi.nlm.nih.gov/12231542/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2019-04-24)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03925662	RECRUITING	Colorectal Cancer	Sherief Abd-Elsalam	2019-04-01	PHASE3
NCT06800248	NOT_YET_RECRUITING	Trichuris Trichiura; Infection; Hookworm Infection; Ascaris Lumbricoides Infection	Swiss Tropical & Public Health Institute	2026-11-06	PHASE3
NCT01837862	ACTIVE_NOT_RECRUITING	Pilomyxoid Astrocytoma; Pilocytic Astrocytoma; Glioma, Astrocytic; Optic Nerve Glioma; Pleomorphic Xanthoastrocytoma; Glioblastoma Multiforme; Anaplastic Astrocytoma; Gliosarcoma; Diffuse Intrinsic Pontine Glioma; DIPG; Low-grade Glioma; Brainstem Glioma	Julie Krystal	2013-10-22	PHASE1; PHASE2
NCT06736691	ACTIVE_NOT_RECRUITING	Trichuris Trichiura; Infection; Hookworm Infection; Ascaris Lumbricoides Infection	Swiss Tropical & Public Health Institute	2025-11-25	PHASE3
NCT06335160	RECRUITING	Ulcerative Colitis	Tanta University	2024-04-20
NCT06720259	COMPLETED	Trichuris Trichiura; Infection; Hookworm Infection; Ascaris Lumbricoides Infection	Jennifer Keiser	2025-04-16	PHASE2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):