Mebendazole

Catalog No.S4610 Synonyms: Vermox, Telmin, Pantelmin, Mebenvet

For research use only.

Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.

Mebendazole Chemical Structure

CAS No. 31431-39-7

Selleck's Mebendazole has been cited by 4 Publications

Purity & Quality Control

Choose Selective Parasite Inhibitors

Biological Activity

Description Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
In vitro

mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2].

In vivo When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: A549, WI38 normal fibroblasts, H1299 and H460 cancer cell line
  • Concentrations: 0, 0.2, 0.5, 1 μM
  • Incubation Time: 48 h
  • Method: When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.
Animal Research:[1]
  • Animal Models: Mice
  • Dosages: 12.5 and 25 mg/kg/day
  • Administration: oral administration

Solubility (25°C)

In vitro

DMSO 6 mg/mL
(20.31 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 295.29
Formula

C16H13N3O3

CAS No. 31431-39-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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