Methylthiouracil

Catalog No.S3138 Synonyms: NSC-193526, NSC-9378

For research use only.

Methylthiouracil (NSC-193526, NSC-9378) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

Methylthiouracil Chemical Structure

CAS No. 56-04-2

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Biological Activity

Description Methylthiouracil (NSC-193526, NSC-9378) is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
Targets
TNF-α [3] IL-6 [3] NF-κB [3] ERK1/2 [3]
In vitro

Methylthiouracil acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. Methylthiouracil is also used in combination with radioactive iodine.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 142.18
Formula

C5H6N2OS

CAS No. 56-04-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=O)NC(=S)N1

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