Menadione

Catalog No.S1949 Synonyms: Vitamin K3

Menadione Chemical Structure

Molecular Weight(MW): 172.18

Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

Choose Selective phosphatase Inhibitors

Biological Activity

Description Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
Targets
Cdc25 phosphatase [6] DNA polymerase γ [7]
In vitro

Menadione prevents mitochondrial Ca(2+) uptake in normal pancreatic acinar cells, which permits rapid spread of Ca(2+) throughout the cell. Menadione-induced mitochondrial depolarisation is due to induction of the permeability transition pore. [1] Menadione (nontoxic concentration) results in a brief activation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in the RALA255-10G rat hepatocyte cell line. [2] Menadione is equipotent against multidrug-resistant and parental leukemia cell lines with IC50 values of 13.5 mM and 18 mM, respectively. Menadione inhibits the incorporation of radioactive thymidine, uridine and amino acids into DNA, RNA and protein, respectively, in three humancancer cell lines. [3] Menadione at 1-20 mM dose- and time-dependently inhibits cell proliferation of AR4-2J cells. Menadione (100 mM) causes rapid cell death. Menadione (100 mM) induces DNA smear in electrophoresis indicative of necrosis, while lower concentrations (10-20 mM) induces a DNA ladder indicative of apoptosis. Menadione at 1-20 mM induces wild-type P53, whereas the 100 mM menadione has a minor effect on wild-type P53. [4] Menadione treatment clearly affects the mitochondrial function of Jurkat T cells by inducing a collapse of the inner transmembrane potential (DeltaPsi(m)) and a decrease in inner membrane mass, which could be completely reversed by N-acetylcysteine. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT22 cells MUDGeY5kfGmxbjDhd5NigQ>? M{n0dm5mfXKxcILveIVkfGm4ZTDhZ5Rqfmm2eTDpckBud3W|ZTDIWFIzKGOnbHzzJIF{e2W|c3XkJIF{KHC{ZY\lcpRqd25iZoLvcUBodHW2YX3heIUucW6mdXPl[EBwgGmmYYTpeoUh[2WubDDk[YF1cCCkeTDNWHMh[XO|YYmsJHBFPTB;MD63PVch|ryP NGq4PWgzOzN{N{S2PC=>
HeLa cell NIHRdVZEgXSxdH;4bYNqfHliYYPzZZk> M{TLWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEinTHGgZ4VtdCCuaX7ld{whTUN3ME2zMlch|ryP MlPONVU{Pjl2MEC=
PaCa2 cell MWPQdo9tcW[ncnH0bY9vKGG|c3H5 Mn\nRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCyYX7jdoVifGmlIHPhdoNqdm:vYTDNbYEhWGGFYUKgZ4VtdCCuaX7lJIJ6KGOxbH;ybY1mfHKrYzDhd5NigSxiSVO1NF03NjJizszN NVfEOnh[OTZ{MU[1NFA>
HT-29 cells M1W4T2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mly4O|IhcA>? MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVkvPjlizszN Mom2NlM4QTF|Nke=
DU145 cells NYrJXZR[S3m2b4TvfIlkcXS7IHHzd4F6 NV;Kb|lMPzJiaB?= NVPHRWx{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD17Lki2JO69VQ>? MVGyN|c6OTN4Nx?=
MDA-MB-231 cells NVTXW5N5S3m2b4TvfIlkcXS7IHHzd4F6 M4D5RlczKGh? MoO1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGyMlY5KM7:TR?= M1\uNFI{PzlzM{[3
human A2058 cells NILpSoZEgXSxdH;4bYNqfHliYYPzZZk> NG[1WWhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCOjB3ODDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKG[xcn3hfoFvKG[xcn3heIlwdiCjdDDkZZkhPSCkeTDt[YF{fXKrbnegZYJ{d3KkYX7j[UBifCB2M{Cgco0tKEmFNUC9NVMvPCEQvF2= NYjuO|dxOTl7Nkm0NFA>
SAS cells NV3UWo54S3m2b4TvfIlkcXS7IHHzd4F6 MV:0PEBp MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTRXMh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVQh|ryP MXKyOFkyOzdzMh?=
HaCaT cells MmD1SpVv[3Srb36gZZN{[Xl? NXTKdXV5PDhiaB?= MXfBcpRqcHmyZYLwdo9tcW[ncnH0bZZmKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gTIFE[VRiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCjZoTldkA1QCCqcoOgZpkheGijc3WgZ49vfHKjc4SgcYlkem:|Y3;wfUwhUUN3ME2xOU45KM7:TR?= NGS3XWszPDl4NEK0Oi=>
HeLa cells M4jpRmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGPwW2U1QCCq MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE5KM7:TR?= NX3ZUHI2OjR7MUO3NVI>
CRL2796 cells MnXmR5l1d3SxeHnjbZR6KGG|c3H5 MkjXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR3JNOjd7NjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKG[xcn3hfoFvKG[xcn3heIlwdiCjdDDkZZkhPCCkeTDt[YF{fXKrbnegZYJ{d3KkYX7j[UBifCB2M{Cgco0tKEmFNUC9NlEh|ryP NGnRcXMyQTl4OUSwNC=>
HL60 cells NF;ucG5HfW6ldHnvckBie3OjeR?= M{W1SVUxKM7:TR?= NGLQT|hKdmS3Y4Tpc44hd2ZibnXjdo9{cXNiaX6gbY51[WO2IHj1cYFvKEiONkCgZ4VtdHNiYYPz[ZN{\WRiYYOgZ5l1d3OxbHnjJGxFUCC{ZXzlZZNmKGG2IEWwJJVO NFXCfnYzPTR4MkK3Ny=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 34 mg/mL (197.46 mM)
Ethanol 34 mg/mL (197.46 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 172.18
Formula

C11H8O2

CAS No. 58-27-5
Storage powder
in solvent
Synonyms Vitamin K3

Bio Calculators

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID