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Methyl 4-hydroxycinnamate

Synonyms: OMpCA

Methyl 4-hydroxycinnamate (OMpCA) is a model chromophore of the Photoactive Yellow Protein (PYP).

Methyl 4-hydroxycinnamate Chemical Structure

Methyl 4-hydroxycinnamate Chemical Structure

CAS: 19367-38-5

Purity & Quality Control

Batch: Purity: 99.99%
99.99

Methyl 4-hydroxycinnamate Related Products

Biological Activity

Description Methyl 4-hydroxycinnamate (OMpCA) is a model chromophore of the Photoactive Yellow Protein (PYP).
In vitro
In vitro Methyl p-coumarate significantly suppresses the melanin formation in B16 mouse melanoma cells[1].
Cell Research Cell lines B16 mouse melanoma cells
Concentrations 0.01 mM
Incubation Time 72 h
Method Cells are cultured in RPMI1640 medium in a humidified atmosphere with 10% CO2 at 37℃. Subcultures of cells are plated at a density of 2.0×105 cells/well. Approximately 24h later, the sample is added, and cells are harvested for 72h after drug addition. All samples are dissolved in DMSO and the final DMSO concentration was 0.1% in all experiments. The harvested cells are suspended in 0.5 mL of 1M NaOH solution containing 10% DMSO, which are sonicated and incubated overnight. The inhibition of melanin formation is estimated by the comparison of absorbance at 475 nm with inhibitor-free experiment. The cytotoxicity assay is performed.

Chemical Information & Solubility

Molecular Weight 178.18 Formula

C10H10O3
CAS No. 19367-38-5 SDF Download Methyl 4-hydroxycinnamate SDF
Smiles COC(=O)C=CC1=CC=C(C=C1)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 35 mg/mL ( (196.43 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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