For research use only.
Catalog No.S2484 Synonyms: Win 47203
CAS No. 78415-72-2
Milrinone (Win 47203) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
Selleck's Milrinone has been cited by 2 publications
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Viability of H9c2 cells incubated with MRN-HSA-NPs (black bars) compared with MRN-Lactate (grey bars) at different MRN concentrations, at (a) 4 hours, (b) 24 hours and (c) 48 hours. The graph shows a representative result of mean±SD (n=3). ****P<0.0001, ***P<0.001, **P<0.01 and *P<0.05 were considered significant based on Sidak’s posthoc analysis.
Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360. Milrinone purchased from Selleck.
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|Description||Milrinone (Win 47203) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.|
Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells.  Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase.  Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. 
|In vivo||Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol.  Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs.  Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. |
-  Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.
-  Shipley JB, et al. Am J Med Sci, 1996, 311(6), 286-291.
-  Silver PJ, et al. J Pharmacol Exp Ther, 1988, 247(1), 34-42.
|In vitro||DMSO||42 mg/mL (198.84 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03945708||Recruiting||Device: CytoSorb||Infective Endocarditis||Emma Hansson|CytoSorbents Inc|Sahlgrenska University Hospital Sweden||May 15 2019||Not Applicable|
|NCT04391478||Completed||Drug: Milrinone|Drug: Sildenafil||Persistent Pulmonary Hypertension||Rania Ali El-Farrash|Ain Shams University||January 2015||Phase 1|
|NCT01940250||Completed||Drug: Magnesium Sulphate|Drug: Sterile water||Hand Foot and Mouth Disease||Oxford University Clinical Research Unit Vietnam|Hospital for Tropical Diseases Ho Chi Minh City Vietnam|Children''s Hospital Number 1 Ho Chi Minh City Vietnam||April 21 2014||Phase 2|
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