Milrinone
For research use only. Not for use in humans.
Catalog No.S2484 Synonyms: Win 47203
2 publications
Molecular Weight(MW): 211.22
Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
Selleck's Milrinone has been cited by 2 publications
1 Customer Review
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Viability of H9c2 cells incubated with MRN-HSA-NPs (black bars) compared with MRN-Lactate (grey bars) at different MRN concentrations, at (a) 4 hours, (b) 24 hours and (c) 48 hours. The graph shows a representative result of mean±SD (n=3). ****P<0.0001, ***P<0.001, **P<0.01 and *P<0.05 were considered significant based on Sidak’s posthoc analysis.
Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360. Milrinone purchased from Selleck.
Purity & Quality Control
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Biological Activity
| Description | Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility. | ||||||
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| Targets |
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| In vitro |
Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. [1] Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. [2] Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. [3] |
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| In vivo | Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. [4] Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. [5] Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. [6] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 42 mg/mL (198.84 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 211.22 |
|---|---|
| Formula | C12H9N3O |
| CAS No. | 78415-72-2 |
| Storage | powder |
| in solvent | |
| Synonyms | Win 47203 |
| Smiles | CC1=C(C=C(C#N)C(=O)N1)C2=CC=NC=C2 |
Bio Calculators
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT02077010 | Not yet recruiting | Drug: Milrinone | Heart Failure|Cardiomyopathy | Vanderbilt University Medical Center|University of Kansas | July 1 2019 | Phase 2 |
| NCT03945708 | Recruiting | Device: CytoSorb | Infective Endocarditis | Emma Hansson|CytoSorbent|Sahlgrenska University Hospital Sweden | May 2019 | Phase 4 |
| NCT01940250 | Completed | Drug: Magnesium Sulphate|Drug: Sterile water | Hand Foot and Mouth Disease | Oxford University Clinical Research Unit Vietnam|Hospital for Tropical Diseases Ho Chi Minh City Vietnam|Children''s Hospital Number 1 Ho Chi Minh City Vietnam | April 21 2014 | Phase 2 |
| NCT01966237 | Unknown status | -- | Congenital Heart Disease|Acute Kidney Injury | Children''s Hospital Medical Center Cincinnati|Thrasher Research Fund | September 2013 | -- |
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