For research use only.

Catalog No.S2484 Synonyms: Win 47203

2 publications

Milrinone Chemical Structure

CAS No. 78415-72-2

Milrinone (Win 47203) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Milrinone has been cited by 2 publications

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  • Viability of H9c2 cells incubated with MRN-HSA-NPs (black bars) compared with MRN-Lactate (grey bars) at different MRN concentrations, at (a) 4 hours, (b) 24 hours and (c) 48 hours. The graph shows a representative result of mean±SD (n=3). ****P<0.0001, ***P<0.001, **P<0.01 and *P<0.05 were considered significant based on Sidak’s posthoc analysis.

    Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360. Milrinone purchased from Selleck.

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Biological Activity

Description Milrinone (Win 47203) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
ATPase [1] PDE3 [7] PDE2 [7]
2.1 μM 5.2 μM
In vitro

Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. [1] Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. [2] Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. [3]

In vivo Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. [4] Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. [5] Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. [6]


Solubility (25°C)

In vitro DMSO 42 mg/mL (198.84 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.22


CAS No. 78415-72-2
Storage powder
in solvent
Synonyms Win 47203
Smiles CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03945708 Recruiting Device: CytoSorb Infective Endocarditis Emma Hansson|CytoSorbents Inc|Sahlgrenska University Hospital Sweden May 15 2019 Not Applicable
NCT04391478 Completed Drug: Milrinone|Drug: Sildenafil Persistent Pulmonary Hypertension Rania Ali El-Farrash|Ain Shams University January 2015 Phase 1
NCT01940250 Completed Drug: Magnesium Sulphate|Drug: Sterile water Hand Foot and Mouth Disease Oxford University Clinical Research Unit Vietnam|Hospital for Tropical Diseases Ho Chi Minh City Vietnam|Children''s Hospital Number 1 Ho Chi Minh City Vietnam April 21 2014 Phase 2

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PDE Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID