For research use only. Not for use in humans.
Catalog No.S2484 Synonyms: Win 47203
Molecular Weight(MW): 211.22
Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
Selleck's Milrinone has been cited by 2 publications
1 Customer Review
Viability of H9c2 cells incubated with MRN-HSA-NPs (black bars) compared with MRN-Lactate (grey bars) at different MRN concentrations, at (a) 4 hours, (b) 24 hours and (c) 48 hours. The graph shows a representative result of mean±SD (n=3). ****P<0.0001, ***P<0.001, **P<0.01 and *P<0.05 were considered significant based on Sidak’s posthoc analysis.
Mol Pharm, 2017, doi: 10.1021/acs.molpharmaceut.7b00360. Milrinone purchased from Selleck.
Purity & Quality Control
Choose Selective PDE Inhibitors
|Description||Milrinone is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.|
Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells.  Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase.  Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. 
|In vivo||Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol.  Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs.  Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. |
-  Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.
-  Shipley JB, et al. Am J Med Sci, 1996, 311(6), 286-291.
-  Silver PJ, et al. J Pharmacol Exp Ther, 1988, 247(1), 34-42.
|In vitro||DMSO||42 mg/mL (198.84 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02077010||Not yet recruiting||Drug: Milrinone||Heart Failure|Cardiomyopathy||Vanderbilt University Medical Center|University of Kansas||July 1 2019||Phase 2|
|NCT03945708||Recruiting||Device: CytoSorb||Infective Endocarditis||Emma Hansson|CytoSorbent|Sahlgrenska University Hospital Sweden||May 2019||Phase 4|
|NCT01940250||Completed||Drug: Magnesium Sulphate|Drug: Sterile water||Hand Foot and Mouth Disease||Oxford University Clinical Research Unit Vietnam|Hospital for Tropical Diseases Ho Chi Minh City Vietnam|Children''s Hospital Number 1 Ho Chi Minh City Vietnam||April 21 2014||Phase 2|
|NCT01966237||Unknown status||--||Congenital Heart Disease|Acute Kidney Injury||Children''s Hospital Medical Center Cincinnati|Thrasher Research Fund||September 2013||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.