Catalog No.S7296

For research use only.

ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.

ML324 Chemical Structure

CAS No. 1222800-79-4

Selleck's ML324 has been cited by 9 Publications

Purity & Quality Control

Choose Selective Histone Demethylase Inhibitors

Biological Activity

Description ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.
JMJD2 [1]
(Cell-free assay)
920 nM
In vitro

ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression. [1]

In vivo In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation. [1]

Protocol (from reference)

Animal Research:


  • Animal Models: Mouse ganglia explant model of latently infected mice
  • Dosages: ~50 μM
  • Administration: --

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 349.43


CAS No. 1222800-79-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC(=C3C(=C2)C=CC=N3)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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