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Megestrol

Name: Megestrol
Brand: Selleck Chemicals
SKU: S5738
Rating: 5 (1 reviews)

Synonyms: Megace

Catalog No.S5738 Purity: 99.79%

Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.

Megestrol Chemical Structure

CAS: 3562-63-8

Purity & Quality Control

Batch: S573801 DMSO] 68 mg/mL] false] Ethanol] 5 mg/mL] false] Water] Insoluble] false Purity: 99.79%

99.79

Megestrol Related Products

Related Targets	Estrogen receptor Progesterone receptor ERR	Click to Expand
Related Products	Mifepristone 4-Hydroxytamoxifen (Afimoxifene) Tamoxifen Citrate Estradiol Bazedoxifene (WAY-140424) HCl MPA (Medroxyprogesterone acetate) Megestrol Acetate Cholesterol Diethylstilbestrol Progesterone Toremifene Citrate (NK 622) Endoxifen HCl G15 Bazedoxifene acetate Licochalcone A AZD9496 Levonorgestrel PHTPP Estradiol Benzoate Ethinyl Estradiol Ulipristal Acetate (CDB 2914) Liquiritigenin Brilanestrant (GDC-0810) Raloxifene Etonogestrel Pregnenolone Estriol Lasofoxifene Tartrate Equol Estradiol Cypionate Genistin (Genistoside) (Z)-4-Hydroxytamoxifen Erteberel (LY500307) Estrone Elacestrant (RAD1901) Dihydrochloride Estradiol valerate GSK5182	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Exosome Secretion Related Compound Library Human Hormone Related Compound Library	Click to Expand

Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description	Megestrol, a synthetic progestin, is approved for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis. Megestrol acetate (Megace) is one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05332483	Terminated	Endometrial Cancer	Sunnybrook Health Sciences Centre\|Ontario Institute for Cancer Research	July 5 2022	Phase 1
NCT01589562	Completed	Healthy	Daewon Pharmaceutical Co. Ltd.\|Asan Medical Center	April 2012	Phase 1
NCT00439101	Completed	Malnourished Children With Cancer	University of British Columbia\|University of Alberta	April 2007	Not Applicable
NCT00507949	Completed	Chronic Obstructive Pulmonary Disease	Rottapharm Spain	October 2006	Phase 2

References

Chemical Information & Solubility

Molecular Weight	342.47	Formula	C₂₂H₃₀O₃
CAS No.	3562-63-8	SDF	--
Smiles	CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC12C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (198.55 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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