Home Transmembrane Transporters Sodium Channel inhibitor Mepivacaine HCl For research use only.

Mepivacaine HCl

Mepivacaine is a tertiary amine used as a local anesthetic.

Mepivacaine HCl Chemical Structure

Mepivacaine HCl Chemical Structure

CAS: 1722-62-9

Purity & Quality Control

Batch: S315501 Water] 57 mg/mL] false] Ethanol] 8 mg/mL] false] DMSO] 3 mg/mL] false Purity: 99.90%
99.90

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Signaling Pathway

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Biological Activity

Description Mepivacaine is a tertiary amine used as a local anesthetic.
In Vivo
In vivo The tests made in horse show greater diffusion of mepivacaine between adjacent synovial structures than assumed from previous anatomical, latex injection and contrast arthrographic studies. [1] Ultrasound provides a 37% reduction in the minimum effective anesthetic volume (MEAV50) of 1.5% mepivacaine required to block the sciatic nerve compared with neurostimulation in patients undergoing knee arthroscopy. [2] The use of 3% mepivacaine provides a shorter duration of anesthesia than the lidocaine formulations with epinephrine in the canines and premolars. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04257682 Not yet recruiting
Knee Osteoarthritis|Hip Osteoarthritis
Ottawa Hospital Research Institute
 September 2022 Phase 4
NCT01533545 Terminated
Renal Insufficiency Chronic
Rigshospitalet Denmark
 September 2012 Not Applicable
NCT01032798 Completed
Local Anesthetic Effectiveness
University of Campinas Brazil|Fundação de Amparo à Pesquisa do Estado de São Paulo
 May 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 282.81 Formula

C15H22N2O.HCl

 
CAS No. 1722-62-9 SDF Download Mepivacaine HCl SDF
Smiles CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 57 mg/mL

Ethanol : 8 mg/mL

DMSO : 3 mg/mL ( (10.6 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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