Mepivacaine HCl

Catalog No.S3155

For research use only.

Mepivacaine is a tertiary amine used as a local anesthetic.

Mepivacaine HCl Chemical Structure

CAS No. 1722-62-9

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Biological Activity

Description Mepivacaine is a tertiary amine used as a local anesthetic.
In vivo The tests made in horse show greater diffusion of mepivacaine between adjacent synovial structures than assumed from previous anatomical, latex injection and contrast arthrographic studies. [1] Ultrasound provides a 37% reduction in the minimum effective anesthetic volume (MEAV50) of 1.5% mepivacaine required to block the sciatic nerve compared with neurostimulation in patients undergoing knee arthroscopy. [2] The use of 3% mepivacaine provides a shorter duration of anesthesia than the lidocaine formulations with epinephrine in the canines and premolars. [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 282.81


CAS No. 1722-62-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04257682 Not yet recruiting Drug: Bupivacaine|Drug: Ropivacaine|Drug: Mepivacaine Knee Osteoarthritis|Hip Osteoarthritis Ottawa Hospital Research Institute September 2020 Phase 4
NCT01533545 Terminated Drug: Mepivacaine with epinephrine|Drug: Plain mepivacaine Renal Insufficiency Chronic Rigshospitalet Denmark September 2012 Not Applicable
NCT01032798 Completed Drug: mepivacaine Local Anesthetic Effectiveness University of Campinas Brazil|Fundação de Amparo à Pesquisa do Estado de São Paulo May 2007 Phase 1

(data from, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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