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Memantine HCl NMDAR antagonist

Name: Memantine HCl
Brand: Selleck Chemicals
SKU: S2043
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S2043

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.

Chemical Structure

Molecular Weight: 215.76

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Quality Control

Batch: Purity: 99.66%

99.66

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other NMDAR Inhibitors	(+)-Dizocilpine (MK 801) Maleate (-)-Dizocilpine (MK 801) Maleate NMDA (N-Methyl-D-aspartic acid) Ifenprodil Tartrate Spermidine trihydrochloride Kynurenic acid Mephenesin Quinolinic acid Radiprodil (RGH-896) NMDAR antagonist 1

Solubility

In vitro
Batch:

DMSO : 43 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 43 mg/mL

Ethanol : 43 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.150mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 43 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to make it clear; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	215.76	Formula	C₁₂H₂₁N.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	41100-52-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

Mechanism of Action

Targets/IC₅₀/Ki	NMDAR CYP2B6 (Cell-free assay) 0.51 μM(Ki) CYP2B6 (Cell-free assay) 1.12 μM CYP2D6 (Cell-free assay) 84.4 μM(Ki) CYP2D6 (Cell-free assay) 242.4 μM
In vitro	Memantine inhibits CYP2B6 and CYP2D6 activities with Ki of 76.7 and 94.9 µM, respectively, in human liver microsomes.
References	[1] https://pubmed.ncbi.nlm.nih.gov/16906789/ [2] https://pubmed.ncbi.nlm.nih.gov/15378224/ [3] https://pubmed.ncbi.nlm.nih.gov/15378224/ [4] https://pubmed.ncbi.nlm.nih.gov/32860269/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06275035	Recruiting	Neurocognitive Dysfunction	Tata Memorial Centre	February 22 2024	Phase 3
NCT05804279	Completed	Healthy	Hyundai Pharm	December 28 2022	Phase 1
NCT05063851	Recruiting	Alzheimer Disease	University of Virginia	October 11 2021	Phase 2
NCT05015595	Unknown status	Obsessive-Compulsive Disorder	University of Roma La Sapienza	September 1 2021	Phase 3

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