Name: Memantine HCl
Brand: Selleck Chemicals
SKU: S2043
Availability: InStock
Rating: 5 (3 reviews)

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Quality Control

Batch: Purity: 99.66%

99.66

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other NMDAR Inhibitors	NMDA (N-Methyl-D-aspartic acid) (+)-Dizocilpine (MK 801) Maleate (-)-Dizocilpine (MK 801) Maleate Ifenprodil Tartrate Kynurenic acid Spermidine trihydrochloride Quinolinic acid Mephenesin Radiprodil (RGH-896) NMDAR antagonist 1

Solubility

In vitro
Batch:

DMSO : 43 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 43 mg/mL

Ethanol : 43 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.150mg/ml (9.96mM)	Taking the 1 mL working solution as an example, add 50 μL of 43 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to make it clear; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	215.76	Formula	C₁₂H₂₁N.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	41100-52-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			SMILES	CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	NMDAR CYP2B6 (Cell-free assay) 0.51 μM(Ki) CYP2B6 (Cell-free assay) 1.12 μM CYP2D6 (Cell-free assay) 84.4 μM(Ki) CYP2D6 (Cell-free assay) 242.4 μM
In vitro	Memantine inhibits CYP2B6 and CYP2D6 activities with Ki of 76.7 and 94.9 µM, respectively, in human liver microsomes.
References	[1] https://pubmed.ncbi.nlm.nih.gov/16906789/ [2] https://pubmed.ncbi.nlm.nih.gov/15378224/ [3] https://pubmed.ncbi.nlm.nih.gov/15378224/ [4] https://pubmed.ncbi.nlm.nih.gov/32860269/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-03-04)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04302870	RECRUITING	Motor Neuron Disease, Amyotrophic Lateral Sclerosis	University of Edinburgh	2020-02-27	PHASE2; PHASE3
NCT07560878	RECRUITING	Major Depression	Mclean Hospital	2026-03-11	EARLY_PHASE1
NCT07470606	NOT_YET_RECRUITING	Brain Tumor	The University of Texas Health Science Center at San Antonio	2026-03	PHASE2
NCT00262470	ACTIVE_NOT_RECRUITING	Tachycardia; Chronic Orthostatic Intolerance	Satish R. Raj	1997-04	PHASE1; PHASE2
NCT06727773	RECRUITING	Breast Cancer; Locally Advanced Breast Cancer; Cognitive Impairment; Cognitive Decline; Cognitive Change; Breast Cancer Stage I; Breast Cancer Stage II; Breast Cancer Stage III	UNC Lineberger Comprehensive Cancer Center	2025-08-19	PHASE2
NCT07505979	NOT_YET_RECRUITING	Brain Metastases From Solid Tumors	National Taiwan University Hospital	2026-04	PHASE2

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Memantine HCl NMDAR antagonist

Chemical Structure

Molecular Weight: 215.76