Memantine HCl

Catalog No.S2043

For research use only.

Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.

Memantine HCl Chemical Structure

CAS No. 41100-52-1

Selleck's Memantine HCl has been cited by 1 Publication

Purity & Quality Control

Choose Selective NMDAR Inhibitors

Biological Activity

Description Memantine HCl is an antagonist of NMDAR. It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of 0.51 μM and 84.4 μM, respectively.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 215.76
Formula

C12H21N.HCl

CAS No. 41100-52-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05063851 Recruiting Drug: Memantine Hydrochloride Tablets|Drug: Placebo Alzheimer Disease University of Virginia October 11 2021 Phase 2
NCT05015595 Not yet recruiting Drug: Memantine Oral Tablet|Drug: Placebo Obsessive-Compulsive Disorder University of Roma La Sapienza September 1 2021 Phase 3
NCT04698525 Completed Drug: Valproate Sodium|Drug: Memantine Migraine Headache Universidad Autonoma de San Luis Potosí August 1 2019 Phase 3
NCT03988803 Completed Drug: BI 425809|Drug: Memantine Healthy Boehringer Ingelheim July 17 2019 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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