Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S8764 IITZ-01 <1 mg/mL 100 mg/mL <1 mg/mL
S9424 Liensinine diperchlorate -1 mg/mL 50 mg/mL -1 mg/mL
S9150 Daurisoline -1 mg/mL 64 mg/mL -1 mg/mL
S1105 LY294002 <1 mg/mL 36 mg/mL 21 mg/mL
S1150 Paclitaxel <1 mg/mL 171 mg/mL 18 mg/mL
S2758 Wortmannin <1 mg/mL 85 mg/mL <1 mg/mL
S2767 3-Methyladenine (3-MA) 10 mg/mL 3 mg/mL 4 mg/mL
S2775 Nocodazole <1 mg/mL 7 mg/mL <1 mg/mL
S4157 Chloroquine Phosphate 100 mg/mL <1 mg/mL <1 mg/mL
S1835 Azithromycin <1 mg/mL 100 mg/mL 100 mg/mL
S7289 PFK15 <1 mg/mL 19 mg/mL 2 mg/mL
S7885 SBI-0206965 <1 mg/mL 97 mg/mL 10 mg/mL
S8576 EAD1 100 mg/mL 100 mg/mL 100 mg/mL
S7888 Spautin-1 <1 mg/mL 54 mg/mL 7 mg/mL
S8317 3BDO <1 mg/mL 65 mg/mL 49 mg/mL
S7811 MHY1485 <1 mg/mL 4 mg/mL <1 mg/mL
S8596 Autophinib <1 mg/mL 69 mg/mL <1 mg/mL
S3758 Sinomenine hydrochloride -1 mg/mL 73 mg/mL -1 mg/mL
S8369 Lys05 3 mg/mL 9 mg/mL <1 mg/mL
S4430 Hydroxychloroquine Sulfate 67 mg/mL <1 mg/mL <1 mg/mL
S7949 MRT68921 HCl <1 mg/mL <1 mg/mL <1 mg/mL
S7683 PIK-III <1 mg/mL 63 mg/mL 63 mg/mL
S8527 ROC-325 <1 mg/mL 4 mg/mL 4 mg/mL
S1047 Vorinostat (SAHA, MK0683) <1 mg/mL 52 mg/mL 3 mg/mL
S1002 ABT-737 <1 mg/mL 100 mg/mL <1 mg/mL
S1049 Y-27632 2HCl 14 mg/mL 64 mg/mL <1 mg/mL
S1039 Rapamycin (Sirolimus) <1 mg/mL 20 mg/mL <1 mg/mL
S1023 Erlotinib HCl (OSI-744) <1 mg/mL 4 mg/mL <1 mg/mL
S9027 Corynoxine <1 mg/mL 77 mg/mL 77 mg/mL
S9310 Isorhychophylline -1 mg/mL 77 mg/mL -1 mg/mL
S5312 Urolithin A <1 mg/mL 45 mg/mL <1 mg/mL
S8595 Tat-beclin 1 (Tat-BECN1) 100 mg/mL -1 mg/mL -1 mg/mL
S1057 Obatoclax Mesylate (GX15-070) <1 mg/mL 83 mg/mL <1 mg/mL
S1038 PI-103 <1 mg/mL 24 mg/mL <1 mg/mL
S1149 Gemcitabine HCl 19 mg/mL <1 mg/mL <1 mg/mL
S2218 Torkinib (PP242) <1 mg/mL 61 mg/mL 18 mg/mL
S1237 Temozolomide <1 mg/mL 38 mg/mL <1 mg/mL
S1950 Metformin HCl 33 mg/mL <1 mg/mL <1 mg/mL
S1573 Fasudil (HA-1077) HCl 65 mg/mL 5 mg/mL <1 mg/mL
S1972 Tamoxifen Citrate <1 mg/mL 100 mg/mL 100 mg/mL
S2827 Torin 1 <1 mg/mL 2 mg/mL <1 mg/mL
S1396 Resveratrol <1 mg/mL 45 mg/mL <1 mg/mL
S1322 Dexamethasone (DHAP) <1 mg/mL 79 mg/mL 6 mg/mL
S1714 Gemcitabine 52 mg/mL 52 mg/mL <1 mg/mL
S7046 Brefeldin A <1 mg/mL 4 mg/mL <1 mg/mL
S2713 Geldanamycin <1 mg/mL 36 mg/mL <1 mg/mL
S2929 Pifithrin-α (PFTα) HBr <1 mg/mL 67 mg/mL <1 mg/mL
S3030 Niclosamide <1 mg/mL <1 mg/mL <1 mg/mL
S1389 Omeprazole <1 mg/mL 69 mg/mL 13 mg/mL
S1979 Amiodarone HCl <1 mg/mL 23 mg/mL 11 mg/mL
S2480 Loperamide HCl <1 mg/mL 22 mg/mL 4 mg/mL
S4028 Dexamethasone Sodium Phosphate 103 mg/mL <1 mg/mL <1 mg/mL
S1693 Carbamazepine <1 mg/mL 47 mg/mL 18 mg/mL
S2458 Clonidine HCl 53 mg/mL 53 mg/mL 53 mg/mL
S1837 Flubendazole <1 mg/mL 3 mg/mL <1 mg/mL
S1747 Nimodipine <1 mg/mL 84 mg/mL 84 mg/mL
S3124 Dexamethasone Acetate <1 mg/mL 87 mg/mL 20 mg/mL
S2491 Nitrendipine <1 mg/mL 72 mg/mL <1 mg/mL
S3653 Spermidine trihydrochloride 50 mg/mL 30 mg/mL <1 mg/mL
S4081 Sulfacetamide Sodium 51 mg/mL 19 mg/mL <1 mg/mL
S8240 SMER28 <1 mg/mL 52 mg/mL 52 mg/mL
S1238 Tamoxifen <1 mg/mL 74 mg/mL 74 mg/mL
S1241 Vincristine sulfate 60 mg/mL 100 mg/mL <1 mg/mL
S1168 Valproic acid sodium salt (Sodium valproate) 33 mg/mL 33 mg/mL 33 mg/mL
S1041 STF-62247 <1 mg/mL 53 mg/mL 3 mg/mL
S4750 Sulfacetamide sodium salt hydrate 50 mg/mL 50 mg/mL 2 mg/mL
Catalog No. Information Product Use Citations Product Validations


IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.


Liensinine diperchlorate

Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.



Daurisoline, a bis-benzylisoquinoline alkaloid isolated from the rhizomes of Menispermum dauricum, is a potent autophagy blockers with antiarrhythmic effects.



LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family.



Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.



Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays.


3-Methyladenine (3-MA)

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. Solutions of 3-MA are best fresh-prepared by heating.



Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively. Nocodazole improves the CRISPR-mediated HDR efficiency and has an additive effect on enhancing precise genome editing.


Chloroquine Phosphate

Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.



Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.



PFK15 is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.



SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2.



EAD1 is a potent autophagy inhibitor with an IC50 of 5.8 μM in the BxPC3 cells. It has antiproliferative activities in lung and pancreatic cancer cells.



Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.



3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs.



MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.



Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.


Sinomenine hydrochloride

Sinomenine (SN), extracted from the Chinese medicinal plant, sinomenium acutum, is a potent anti-inflammatory and neuroprotective agent.



Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.


Hydroxychloroquine Sulfate

Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.


MRT68921 HCl

MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.



PIK-III, which is a selective inhibitor of ​VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates. The IC50 values for VPS34 and PI(3)Kδ are 0.018 μM and 1.2 μM respectively.



ROC-325 is an orally available novel inhibitor of lysosomal-mediated autophagy which diminishes AML cell viability with the IC50 range of 0.7-2.2 μM.


Vorinostat (SAHA, MK0683)

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.



ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.


Y-27632 2HCl

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.


Rapamycin (Sirolimus)

Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.


Erlotinib HCl (OSI-744)

Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.



Corynoxine, a natural oxindole alkaloid, is a new autophagy enhancer.



Isorhynchophylline is a major tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla (Miq.)Jacks (Gouteng in Chinese). It acts as a neuronal autophagy inducer with therapeutic potential for cardiovascular and central nervous system diseases.


Urolithin A

Urolithin A, a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.


Tat-beclin 1 (Tat-BECN1)

Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate autophagy through mobilization of endogenous Beclin 1, induces autophagy in vitro and in vivo and improves clinical outcomes.


Obatoclax Mesylate (GX15-070)

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.



PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.


Gemcitabine HCl

Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.


Torkinib (PP242)

Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively.



Temozolomide is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells.


Metformin HCl

Metformin HCl decreases hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).


Fasudil (HA-1077) HCl

Fasudil(HA-1077), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively.


Tamoxifen Citrate

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.


Torin 1

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.



Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.


Dexamethasone (DHAP)

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.



Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy.


Brefeldin A

Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR(homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR.



Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association.


Pifithrin-α (PFTα) HBr

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.



Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).



Omeprazole is a proton pump inhibitor, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.


Amiodarone HCl

Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.


Loperamide HCl

Loperamide HCl is a selective μ-opioid receptor agonist opioid with Ki of 3.3 nM, 15-fold and 350-fold selective over the δ subtype and the κ subtype of the opioid receptor, used against diarrhea resulting from gastroenteritis or inflammatory bowel disease.


Dexamethasone Sodium Phosphate

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.



Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.


Clonidine HCl

Clonidine HCl is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.



Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.



Nimodipine is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.


Dexamethasone Acetate

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.



Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.


Spermidine trihydrochloride

Spermidine, a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).


Sulfacetamide Sodium

Sulfacetamide Sodium is an anti-biotic.



SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells.



Tamoxifen is an antagonist of the estrogen receptor in breast tissue.


Vincristine sulfate

Vincristine sulfate is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.


Valproic acid sodium salt (Sodium valproate)

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.



STF-62247 is a molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL; 25-fold greater sensitivity observed for cells with VHL deficiency compared to wild-type (VHL+).


Sulfacetamide sodium salt hydrate

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.