Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3S[mtkUUN3ME2wMlAxODNyNjFOwG0> MUXTRW5ITVJ?
OCUB-M NI\wS4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL6TWM2OD1yLkCwNVk1KM7:TR?= MX\TRW5ITVJ?
DOHH-2 M4C2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnIU3hKSzVyPUCuNFAzOjVizszN MXnTRW5ITVJ?
NOS-1 M4L3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3KTWM2OD1yLkCwNlQzKM7:TR?= MVrTRW5ITVJ?
L-363 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DwR2lEPTB;MD6wNFI5PCEQvF2= MkPuV2FPT0WU
RL95-2 NHi5TVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknCTWM2OD1yLkCwN|Ih|ryP M3jqV3NCVkeHUh?=
BL-70 M3L2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPpTWM2OD1yLkCwN|M4KM7:TR?= NXjCTFcyW0GQR1XS
TGBC1TKB NH\QT4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\kTWM2OD1yLkCwN|c6KM7:TR?= MYHTRW5ITVJ?
697 NGHNWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXvTWM2OD1yLkCwOlM1KM7:TR?= NVzOV45EW0GQR1XS
RPMI-8226 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Kxb2lEPTB;MD6wNFY2OSEQvF2= MnnpV2FPT0WU
BL-41 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPlSVJmUUN3ME2wMlAxPjl4IN88US=> MWLTRW5ITVJ?
MRK-nu-1 M{XKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEC3NFch|ryP NY\IVlhtW0GQR1XS
EW-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEC3OFkh|ryP NI\KfotUSU6JRWK=
EVSA-T M3\4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrWTWM2OD1yLkCwPFkzKM7:TR?= NXT6ZYJDW0GQR1XS
HUTU-80 NUW0fZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPaUVB[UUN3ME2wMlAxQTJ7IN88US=> NVfwd4V2W0GQR1XS
VA-ES-BJ MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnyT3NbUUN3ME2wMlAxQTh2IN88US=> MWLTRW5ITVJ?
GCIY NG\Wc3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLNVpJKSzVyPUCuNFExODdizszN Ml74V2FPT0WU
ES6 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknPTWM2OD1yLkCxNFg{KM7:TR?= MX;TRW5ITVJ?
NALM-6 M4LYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEGxNFIh|ryP NEDZT|FUSU6JRWK=
LB996-RCC MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq4[phKSzVyPUCuNFEyOzdizszN MoLKV2FPT0WU
EW-16 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\xdZVKSzVyPUCuNFEyQTJizszN NIrHdm1USU6JRWK=
KALS-1 M4\EXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXTTWM2OD1yLkCxNVk5KM7:TR?= MonsV2FPT0WU
OPM-2 NELiXnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\EfoVKSzVyPUCuNFEzQSEQvF2= MYLTRW5ITVJ?
KU812 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEGyPVYh|ryP M4PUWnNCVkeHUh?=
A4-Fuk MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr0T41vUUN3ME2wMlAyOzF7IN88US=> M1;TNXNCVkeHUh?=
KGN NXz5bppkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\0bmlEPTB;MD6wNVM2QSEQvF2= NG\MXoVUSU6JRWK=
KS-1 NW\ufoJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEGzPVIh|ryP Mlj6V2FPT0WU
no-11 NGntfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7VU|NKSzVyPUCuNFE{QTVizszN NWTib4FPW0GQR1XS
PSN1 M3Pscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXZRpBnUUN3ME2wMlAyPDB7IN88US=> NFPRO2hUSU6JRWK=
SK-LMS-1 M{i1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pkd2lEPTB;MD6wNVQyOyEQvF2= M1T0S3NCVkeHUh?=
LS-411N MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfHVnJKUUN3ME2wMlAyPDN7IN88US=> MYPTRW5ITVJ?
HT-144 M2m1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7BTWM2OD1yLkCxOFUyKM7:TR?= MWDTRW5ITVJ?
ACN Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzMUZZ5UUN3ME2wMlAyPSEQvF2= MVfTRW5ITVJ?
RKO MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe2OmFKSzVyPUCuNFE2OzNizszN M{H2cXNCVkeHUh?=
CMK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEG1OFMh|ryP NX\KZ3h2W0GQR1XS
GB-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi1[ZdKSzVyPUCuNFE2PTNizszN NWPsS|BwW0GQR1XS
KE-37 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEG1O|Mh|ryP NGe0N3lUSU6JRWK=
no-10 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;OSmlEPTB;MD6wNVU5PCEQvF2= M4TMNHNCVkeHUh?=
MOLT-16 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjHTWM2OD1yLkCxOlIzKM7:TR?= M2HxcHNCVkeHUh?=
HEL NYTUTHVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4eyXmlEPTB;MD6wNVY1KM7:TR?= NVHFflNuW0GQR1XS
NCI-H1355 NUfBTnBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrOc4dyUUN3ME2wMlAyPjR4IN88US=> NEHP[2NUSU6JRWK=
IST-MEL1 Mo\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LOTmlEPTB;MD6wNVc4PCEQvF2= M4XNSHNCVkeHUh?=
MHH-PREB-1 M4fjemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnFT|JWUUN3ME2wMlAyQDF6IN88US=> M{XsZnNCVkeHUh?=
ES8 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKzTWM2OD1yLkCxPFQ1KM7:TR?= NVHsTpkxW0GQR1XS
LC-2-ad NYPxXnBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMEKxN|ch|ryP MoHZV2FPT0WU
LAMA-84 NXLj[FNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPRXo5lUUN3ME2wMlAzOTZ5IN88US=> NHvqPJNUSU6JRWK=
BV-173 MlHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEKyNFMh|ryP MXHTRW5ITVJ?
SW872 NGfZZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEKyOFch|ryP Mn:1V2FPT0WU
SK-UT-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEKyOlEh|ryP M{\6dXNCVkeHUh?=
OS-RC-2 M{DsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjpc4VKSzVyPUCuNFI{OjNizszN NVX4eoRMW0GQR1XS
NCI-H747 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoixTWM2OD1yLkCyN|Mh|ryP MWDTRW5ITVJ?
MZ2-MEL NVSzeFdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMEKzN|ch|ryP NIjpWGxUSU6JRWK=
TE-11 NXXLO45UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfiTZVKSzVyPUCuNFI{PzJizszN M4X6UnNCVkeHUh?=
KURAMOCHI NGq5RpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljiTWM2OD1yLkCyOFE1KM7:TR?= M1vBWXNCVkeHUh?=
HD-MY-Z MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v5NWlEPTB;MD6wNlQzPiEQvF2= NXXrXI5nW0GQR1XS
GI-1 NHXSfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O0XGlEPTB;MD6wNlQ3QSEQvF2= NX\FR3JiW0GQR1XS
LB1047-RCC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4OWVGUUN3ME2wMlAzPDh6IN88US=> MXfTRW5ITVJ?
TE-12 M{DKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXGb4xKSzVyPUCuNFI2PSEQvF2= M360bXNCVkeHUh?=
MZ7-mel MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3mzcWlEPTB;MD6wNlYxQSEQvF2= NYPjTGxUW0GQR1XS
MMAC-SF Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEK2N|Mh|ryP NHLoeJhUSU6JRWK=
A101D MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NISxbGZKSzVyPUCuNFI3PSEQvF2= M1\vOnNCVkeHUh?=
GR-ST MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrnRpVKSzVyPUCuNFI3PTVizszN MYTTRW5ITVJ?
MC116 MnXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTQZYk1UUN3ME2wMlAzPjhizszN MX3TRW5ITVJ?
Ramos-2G6-4C10 NW\MXoxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjtVWFKSzVyPUCuNFI4PSEQvF2= MYfTRW5ITVJ?
ATN-1 M3\mSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH6WIJnUUN3ME2wMlAzPzh7IN88US=> NG\FTmxUSU6JRWK=
MFH-ino MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTEdWtPUUN3ME2wMlAzQDF{IN88US=> MUTTRW5ITVJ?
DEL Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S2PWlEPTB;MD6wNlgyPSEQvF2= MXXTRW5ITVJ?
OCI-AML2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[xOZp{UUN3ME2wMlAzQDdzIN88US=> NUDLdmNDW0GQR1XS
LXF-289 Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEK4O|Ih|ryP M{W4WnNCVkeHUh?=
IA-LM MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvTS5RKSzVyPUCuNFI6OTdizszN M2TCT3NCVkeHUh?=
EoL-1-cell M3e1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL1UHRbUUN3ME2wMlAzQTl4IN88US=> NWnUb|FQW0GQR1XS
OVCAR-4 NIO0OWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvlXFZjUUN3ME2wMlA{ODl2IN88US=> MX\TRW5ITVJ?
ES1 NYjvd4l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PLNGlEPTB;MD6wN|A6PyEQvF2= NV\LZmU6W0GQR1XS
CESS NEmyPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLaeJRKSzVyPUCuNFMxQTlizszN MoG3V2FPT0WU
GAK M1Xx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEOxPFYh|ryP NXW3[VlIW0GQR1XS
NTERA-S-cl-D1 M1roOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEOyNlYh|ryP M2LsfnNCVkeHUh?=
TE-10 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEOzNVEh|ryP NIfPZ|BUSU6JRWK=
CCRF-CEM MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnndGlOUUN3ME2wMlA{OzdzIN88US=> M{TWenNCVkeHUh?=
NMC-G1 NUGwdlR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEO0OFgh|ryP M13hUHNCVkeHUh?=
HOP-62 MmLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmwSVZQUUN3ME2wMlA{PTV4IN88US=> MU\TRW5ITVJ?
SH-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\jTWM2OD1yLkCzOVgzKM7:TR?= NYTPRpU5W0GQR1XS
NCI-H1648 NXT1UJRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEO2NlIh|ryP Ml7MV2FPT0WU
EB-3 M{nHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEO2OFMh|ryP NE\FcnVUSU6JRWK=
BB65-RCC NWflXoJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPlTWM2OD1yLkCzOlkyKM7:TR?= M3:zPHNCVkeHUh?=
BE-13 M3TOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nUSmlEPTB;MD6wN|c2QSEQvF2= Mli4V2FPT0WU
CP67-MEL M{XSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH0TWM2OD1yLkCzO|U6KM7:TR?= NEj5RmxUSU6JRWK=
SW954 M{XBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jVRWlEPTB;MD6wN|c6KM7:TR?= M4fwWXNCVkeHUh?=
TE-5 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEO4OVQh|ryP NHvKU2dUSU6JRWK=
HCE-4 NW[5THdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMEO4OVUh|ryP M{jLRnNCVkeHUh?=
LC-1F Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;Yb2lEPTB;MD6wN|k5QSEQvF2= MUTTRW5ITVJ?
TK10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXXSoZxUUN3ME2wMlA1ODF7IN88US=> MlfmV2FPT0WU
SJSA-1 M3nWXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP2[mJKSzVyPUCuNFQyQDhizszN MVzTRW5ITVJ?
Daudi MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH5VnZKSzVyPUCuNFQzOjVizszN NGTwS2NUSU6JRWK=
SW982 NUDReVhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nXWGlEPTB;MD6wOFI1PiEQvF2= NU\Kb3pkW0GQR1XS
SF126 NUjmbZV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMESzOlEh|ryP NHPIbXpUSU6JRWK=
TE-15 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHOfndKSzVyPUCuNFQ1OzVizszN MYTTRW5ITVJ?
COLO-684 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP3bpdMUUN3ME2wMlA1PTZzIN88US=> NYDlbIxEW0GQR1XS
8-MG-BA MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG3fGFuUUN3ME2wMlA1PjJ7IN88US=> MoXUV2FPT0WU
NB13 NILSPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33OdGlEPTB;MD6wOFc4PiEQvF2= NGjHc5JUSU6JRWK=
HCC1599 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMES4O|kh|ryP M1rUZnNCVkeHUh?=
SK-PN-DW NH[xTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DkcGlEPTB;MD6wOFk1QSEQvF2= MXXTRW5ITVJ?
ALL-PO MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkftTWM2OD1yLkC0PVU3KM7:TR?= NF34Vo9USU6JRWK=
NB6 M{Lkcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHXTWM2OD1yLkC1NlcyKM7:TR?= NXnpe5BYW0GQR1XS
IST-SL2 NXHXeIt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzbWlEPTB;MD6wOVM3OiEQvF2= NIX0OpJUSU6JRWK=
BB30-HNC NG\UVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHyW4ZYUUN3ME2wMlA2PzNizszN M1e2O3NCVkeHUh?=
SW962 NGH0S4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLPTWM2OD1yLkC1O|Y{KM7:TR?= MYHTRW5ITVJ?
TGBC24TKB NVLVXFhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PPcmlEPTB;MD6wOVc6QSEQvF2= MVPTRW5ITVJ?
KINGS-1 NUf5dWdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;VTWM2OD1yLkC1PFA{KM7:TR?= M3;HdnNCVkeHUh?=
HC-1 MlOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXiWZBKSzVyPUCuNFU5OjdizszN MXTTRW5ITVJ?
RS4-11 Ml7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\uTWM2OD1yLkC1PVM5KM7:TR?= MnHKV2FPT0WU
LS-123 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfGTWM2OD1yLkC1PVQzKM7:TR?= NX6yOVVqW0GQR1XS
A3-KAW MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK0TWM2OD1yLkC2NlI2KM7:TR?= NFrOS5dUSU6JRWK=
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NCI-H1694 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;MTWM2OD1yLkWwOlk4KM7:TR?= M{H6b3NCVkeHUh?=
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D-263MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;EU2ZVUUN3ME2wMlY3OTBzIN88US=> NISyPZRUSU6JRWK=
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COR-L88 M4G4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFwMUGzOVQh|ryP MlPNV2FPT0WU
CPC-N MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvvTWM2OD1zLkG1PFg5KM7:TR?= NFfiXohUSU6JRWK=
NCI-H2107 NGPiVFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrvTWM2OD1zLkG3NlYyKM7:TR?= M{W5RnNCVkeHUh?=
ECC4 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTFwMUi2PVMh|ryP MkHqV2FPT0WU
NCI-H2141 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwMUmyPVkh|ryP MUjTRW5ITVJ?
NCI-H1770 NV7DV5loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPFZXBKSzVyPUGuN|I6OjhizszN NH\5Z4ZUSU6JRWK=
NCI-SNU-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFwM{OwOEDPxE1? MUXTRW5ITVJ?
LU-165 NUj6UZBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnVTWM2OD1zLkS1OFY4KM7:TR?= M2XBcHNCVkeHUh?=
Raji M4TkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H2W2lEPTB;MT60O|I2QSEQvF2= M3fLTXNCVkeHUh?=
EW-24 M4TBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG3TWM2OD1zLkW0OlE6KM7:TR?= NXvuU|huW0GQR1XS
KP-N-RT-BM-1 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XWTWlEPTB;MT61OlU2OSEQvF2= NGrTeVRUSU6JRWK=
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SCLC-21H MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELIcHdKSzVyPUGuOlY3PTFizszN NFPie4xUSU6JRWK=
SIMA NXrNUWx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\idY81UUN3ME2xMlY5OjN|IN88US=> NXLGOpI6W0GQR1XS
NCI-H1304 M16yN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTFwN{C3OlUh|ryP MnnlV2FPT0WU
REH NUW4elV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwN{GwO|gh|ryP MVTTRW5ITVJ?
KP-N-YS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwOUO1OVEh|ryP MWHTRW5ITVJ?
DMS-153 M4[2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknjTWM2OD1zLkm3OVkh|ryP NYL0WoZKW0GQR1XS
NB10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\5ZmlEPTB;Mj6yNFg4QCEQvF2= NUnieZFrW0GQR1XS
NCI-H345 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHWTWM2OD1{Lk[xPVA2KM7:TR?= Mo\zV2FPT0WU
SK-N-FI M3P6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHm[HJKSzVyPUKuO|U{QDFizszN MnfRV2FPT0WU
NCI-H1092 NFzHXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPwTWM2OD1{Lkm1N|k1KM7:TR?= M2rIVnNCVkeHUh?=
KM-H2 NGi4dFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\kR446UUN3ME2zMlY2Ozl4IN88US=> MWLTRW5ITVJ?
KG-1 NXnSdoRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnPTWM2OD1|LkexOlg5KM7:TR?= NVLofYFmW0GQR1XS
D-283MED M1PQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jsU2lEPTB;Mz63OVg4KM7:TR?= NX3Kfmg{W0GQR1XS
LU-65 NEfuWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nDcmlEPTB;ND6xNVQ5PSEQvF2= NH23R4JUSU6JRWK=
MSTO-211H MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\Dd2lEPTB;ND6xPFg6QCEQvF2= NXXyWYxCW0GQR1XS
NCI-H2081 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTRwMkmxO|Qh|ryP NXXKdXNoW0GQR1XS
D-247MG NUnoWWRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLFdGFKSzVyPUSuOFMyQTFizszN M{HWenNCVkeHUh?=
P31-FUJ NIm3[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK2TVRKSzVyPUSuOFUxOTlizszN NWO1T4NFW0GQR1XS
DMS-79 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfWTWM2OD12LkmzNVg{KM7:TR?= NFKy[4FUSU6JRWK=
KASUMI-1 M2P2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TCOWlEPTB;ND65O|UxQSEQvF2= NFuyRlRUSU6JRWK=
JVM-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTVwMkWwNVQh|ryP MWPTRW5ITVJ?
LAN-6 M{jaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjHTWM2OD13LkWxO|M3KM7:TR?= MX;TRW5ITVJ?
DJM-1 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny3TWM2OD13LkW2NFI6KM7:TR?= MVzTRW5ITVJ?
JVM-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HqO2lEPTB;NT62O|A6OiEQvF2= NEjHPYRUSU6JRWK=
U-87-MG MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D5XWlEPTB;NT64PVk3PCEQvF2= NVHE[WVQW0GQR1XS
SHP-77 NHrNPFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXsTWM2OD13Lkm0PVI5KM7:TR?= M{C4TnNCVkeHUh?=
RPMI-8866 NHzRSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTZwMkewNVMh|ryP NGDRfpZUSU6JRWK=
ES7 M1vVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nL[mlEPTB;Nj6zPVkzPCEQvF2= NVP6ZZUzW0GQR1XS
WSU-NHL M2rqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rQbmlEPTB;Nj61NVYxQSEQvF2= MkDQV2FPT0WU
CAS-1 M3Huemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT2e4VuUUN3ME23MlA6PzR7IN88US=> MX3TRW5ITVJ?
MHH-NB-11 MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRThwMkOxOVIh|ryP M33IT3NCVkeHUh?=
ES5 MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor2TWM2OD17LkWyNlg3KM7:TR?= M{e3XXNCVkeHUh?=
HDLM-2 M1rDOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTlwOUW5NFIh|ryP NVTzRXFEW0GQR1XS
NCI-H2171 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHZTnNKSzVyPUGwMlU6OjdizszN M2DoTHNCVkeHUh?=
LNCaP-Clone-FGC M2Gy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17Td2lEPTB;MUGuN|cyQCEQvF2= MoryV2FPT0WU
NCI-H1395 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWruSGxlUUN3ME2xNk4zPjl7IN88US=> NFXLbHRUSU6JRWK=
NCI-H1436 NVi2NYZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXUV3FUUUN3ME2xN{4{OTl3IN88US=> M1j6fXNCVkeHUh?=
RCC10RGB M{XpOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjYcpRKSzVyPUGzMlMzOjFizszN NH73bZRUSU6JRWK=
SW684 NXvseHI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHrdFZHUUN3ME2xN{46Pzl5IN88US=> MYHTRW5ITVJ?
NCI-H1650 MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\KXmlEPTB;MUWuNFQ1PyEQvF2= MXPTRW5ITVJ?
EW-13 M1u4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvhU5NRUUN3ME2xOU4zODJzIN88US=> MnzZV2FPT0WU
EC-GI-10 NGmxN3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrrV3E2UUN3ME2xOU45PjR2IN88US=> NH7xTXpUSU6JRWK=
CHP-126 NFzETGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH3TWM2OD1zNz6xPVE5KM7:TR?= M3jJRnNCVkeHUh?=
NCI-H226 MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLP[YEzUUN3ME2xPE4xPDB|IN88US=> M1TjfXNCVkeHUh?=
NCI-H1838 NHe1d49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJyLkG4OFgh|ryP NIPyZmRUSU6JRWK=
EW-11 MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPUT5ZKSzVyPUK0MlI4OThizszN M1vOcHNCVkeHUh?=
EB2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL2cWZLUUN3ME2zNU42OzF6IN88US=> NHnzU2lUSU6JRWK=
D-502MG NHXXVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Ox[2lEPTB;NEOuPVIzQSEQvF2= NWDRO4lZW0GQR1XS
U-698-M MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTR6Lki2O|Eh|ryP M4jLN3NCVkeHUh?=
ES3 NWHjVpRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr5PJIzUUN3ME20PU4{QDl|IN88US=> Ml\BV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID