Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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Cited by 11 Publications

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  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NUHrTYl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMECwN|A3KM7:TR?= MWjTRW5ITVJ?
OCUB-M MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMECxPVQh|ryP NFrEeoxUSU6JRWK=
DOHH-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fCXmlEPTB;MD6wNFIzPSEQvF2= Ml71V2FPT0WU
NOS-1 MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PySGlEPTB;MD6wNFI1OiEQvF2= M13jdHNCVkeHUh?=
L-363 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPvTWM2OD1yLkCwNlg1KM7:TR?= NX3Ne2JQW0GQR1XS
RL95-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi1ZnRKSzVyPUCuNFA{OiEQvF2= NYq4Roh{W0GQR1XS
BL-70 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXyTWM2OD1yLkCwN|M4KM7:TR?= NGflN2lUSU6JRWK=
TGBC1TKB NFf3e5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPGTWM2OD1yLkCwN|c6KM7:TR?= NH3RUppUSU6JRWK=
697 M1roOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljNTWM2OD1yLkCwOlM1KM7:TR?= M1PUNXNCVkeHUh?=
RPMI-8226 M1HQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHWe2RKSzVyPUCuNFA3PTFizszN NEnmW|hUSU6JRWK=
BL-41 Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjpcmtIUUN3ME2wMlAxPjl4IN88US=> MXrTRW5ITVJ?
MRK-nu-1 NVjlfGptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPtTWM2OD1yLkCwO|A4KM7:TR?= MWDTRW5ITVJ?
EW-1 M363VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMEC3OFkh|ryP NX7zRXFyW0GQR1XS
EVSA-T NH;rdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jadmlEPTB;MD6wNFg6OiEQvF2= Mk\EV2FPT0WU
HUTU-80 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEC5Nlkh|ryP NHnhVoxUSU6JRWK=
VA-ES-BJ MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK4cmFKSzVyPUCuNFA6QDRizszN NXK1N5d4W0GQR1XS
GCIY NXW5VYZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjSfWRwUUN3ME2wMlAyODB5IN88US=> MlHiV2FPT0WU
ES6 M1zNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDpXHBxUUN3ME2wMlAyODh|IN88US=> NHHST2JUSU6JRWK=
NALM-6 NX;C[pFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P1XWlEPTB;MD6wNVExOiEQvF2= MVPTRW5ITVJ?
LB996-RCC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO0W3dKSzVyPUCuNFEyOzdizszN MkHnV2FPT0WU
EW-16 NXGw[YZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEGxPVIh|ryP NUHxbo9wW0GQR1XS
KALS-1 NX7rXlk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PMfGlEPTB;MD6wNVE6QCEQvF2= M3;YNHNCVkeHUh?=
OPM-2 NGn6S29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDzTWM2OD1yLkCxNlkh|ryP NHXQSWFUSU6JRWK=
KU812 NH;yUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjabnFKSzVyPUCuNFEzQTZizszN NGS1ZZlUSU6JRWK=
A4-Fuk MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEGzNVkh|ryP NXHiZlJ6W0GQR1XS
KGN NXPJeoNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\UTWM2OD1yLkCxN|U6KM7:TR?= M2\hSXNCVkeHUh?=
KS-1 MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLWT|loUUN3ME2wMlAyOzl{IN88US=> NVvhdYFGW0GQR1XS
no-11 MojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEGzPVUh|ryP MUPTRW5ITVJ?
PSN1 M{TFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfTRolKSzVyPUCuNFE1ODlizszN MX3TRW5ITVJ?
SK-LMS-1 NV3WXnNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjHPVJGUUN3ME2wMlAyPDF|IN88US=> MkHqV2FPT0WU
LS-411N NHHJcllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS0TWdKSzVyPUCuNFE1OzlizszN MkPZV2FPT0WU
HT-144 MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PZd2lEPTB;MD6wNVQ2OSEQvF2= MXPTRW5ITVJ?
ACN NY\tcXR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrXTWM2OD1yLkCxOUDPxE1? MV7TRW5ITVJ?
RKO MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLxOWlUUUN3ME2wMlAyPTN|IN88US=> NHT2dXBUSU6JRWK=
CMK MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHqRo1NUUN3ME2wMlAyPTR|IN88US=> NVSyW5hEW0GQR1XS
GB-1 NYnFRYR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHHUWlKSzVyPUCuNFE2PTNizszN M{\TR3NCVkeHUh?=
KE-37 NWHiU4xNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrkN2xXUUN3ME2wMlAyPTd|IN88US=> MV7TRW5ITVJ?
no-10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfaVmdKSzVyPUCuNFE2QDRizszN MWXTRW5ITVJ?
MOLT-16 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEG2NlIh|ryP MlrOV2FPT0WU
HEL NFTFRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3EcHpKSzVyPUCuNFE3PCEQvF2= M3SyPXNCVkeHUh?=
NCI-H1355 NUPiclZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnFTWM2OD1yLkCxOlQ3KM7:TR?= NVLpXXR[W0GQR1XS
IST-MEL1 M1j5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojNTWM2OD1yLkCxO|c1KM7:TR?= NFzqeWVUSU6JRWK=
MHH-PREB-1 NYr3SXJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojLTWM2OD1yLkCxPFE5KM7:TR?= NX2yUoJPW0GQR1XS
ES8 NV7GcZZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEG4OFQh|ryP MmHkV2FPT0WU
LC-2-ad M{Dw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEKxN|ch|ryP M1\USXNCVkeHUh?=
LAMA-84 NU\4fVZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX1TWM2OD1yLkCyNVY4KM7:TR?= NIDrOFNUSU6JRWK=
BV-173 NFPT[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrsPFFKSzVyPUCuNFIzODNizszN M3fnbHNCVkeHUh?=
SW872 NYjOcZk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofxTWM2OD1yLkCyNlQ4KM7:TR?= NEiwTnZUSU6JRWK=
SK-UT-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\3SGZWUUN3ME2wMlAzOjZzIN88US=> MorTV2FPT0WU
OS-RC-2 NVjIXItQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nmZ2lEPTB;MD6wNlMzOyEQvF2= MnTIV2FPT0WU
NCI-H747 NHnhO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;mTmlEPTB;MD6wNlM{KM7:TR?= Ml75V2FPT0WU
MZ2-MEL MmnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDlZoV6UUN3ME2wMlAzOzN5IN88US=> MmnOV2FPT0WU
TE-11 NHLlbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GyfmlEPTB;MD6wNlM4OiEQvF2= M4PHVnNCVkeHUh?=
KURAMOCHI NHzUfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjvTWM2OD1yLkCyOFE1KM7:TR?= MojnV2FPT0WU
HD-MY-Z NFrjcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4H2UGlEPTB;MD6wNlQzPiEQvF2= M3nodXNCVkeHUh?=
GI-1 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPBN45KSzVyPUCuNFI1PjlizszN NHvFeJRUSU6JRWK=
LB1047-RCC NVK2Z4VZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEK0PFgh|ryP NIHtVHlUSU6JRWK=
TE-12 Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fOXmlEPTB;MD6wNlU2KM7:TR?= MYPTRW5ITVJ?
MZ7-mel M33jXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS1[nJKSzVyPUCuNFI3ODlizszN NF\sO|JUSU6JRWK=
MMAC-SF NEfQOHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnrUFJKSzVyPUCuNFI3OzNizszN MojrV2FPT0WU
A101D M3T2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3mNmxtUUN3ME2wMlAzPjVizszN NUTTcJJUW0GQR1XS
GR-ST MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLBTWM2OD1yLkCyOlU2KM7:TR?= NXHLenlzW0GQR1XS
MC116 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fXNGlEPTB;MD6wNlY5KM7:TR?= M1T1fnNCVkeHUh?=
Ramos-2G6-4C10 NHPob3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHwTIlCUUN3ME2wMlAzPzVizszN M33uW3NCVkeHUh?=
ATN-1 NUjORVhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j5N2lEPTB;MD6wNlc5QSEQvF2= M3nyOXNCVkeHUh?=
MFH-ino NWXiXHczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH6XlhKSzVyPUCuNFI5OTJizszN MVXTRW5ITVJ?
DEL M1:wbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfiTWM2OD1yLkCyPFE2KM7:TR?= NHrlNpFUSU6JRWK=
OCI-AML2 NFfab2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PR[2lEPTB;MD6wNlg4OSEQvF2= MljBV2FPT0WU
LXF-289 M{T3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH5[IdKSzVyPUCuNFI5PzJizszN NUDaRmpDW0GQR1XS
IA-LM MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH0UFJKSzVyPUCuNFI6OTdizszN MX3TRW5ITVJ?
EoL-1-cell NVfUXIJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrlRlhrUUN3ME2wMlAzQTl4IN88US=> NEXKOGdUSU6JRWK=
OVCAR-4 NGXzOmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nTdGlEPTB;MD6wN|A6PCEQvF2= NGPkfnhUSU6JRWK=
ES1 NVjZZ3A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W5[WlEPTB;MD6wN|A6PyEQvF2= NG\4dlFUSU6JRWK=
CESS M{X2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX1e2JKSzVyPUCuNFMxQTlizszN MnHmV2FPT0WU
GAK NXXDZm5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMEOxPFYh|ryP M{izUHNCVkeHUh?=
NTERA-S-cl-D1 MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEOyNlYh|ryP MlKzV2FPT0WU
TE-10 NXPHfFZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L3[2lEPTB;MD6wN|MyOSEQvF2= NITuV4NUSU6JRWK=
CCRF-CEM NHPKWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH6[lhKSzVyPUCuNFM{PzFizszN M13xNnNCVkeHUh?=
NMC-G1 NFjCXmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zOWWlEPTB;MD6wN|Q1QCEQvF2= MmHSV2FPT0WU
HOP-62 M2fzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEO1OVYh|ryP M1Lhb3NCVkeHUh?=
SH-4 NGLCVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEO1PFIh|ryP MWPTRW5ITVJ?
NCI-H1648 NEjxNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHkU3F7UUN3ME2wMlA{PjJ{IN88US=> Mmr6V2FPT0WU
EB-3 NEXlXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEO2OFMh|ryP NV7uXVVQW0GQR1XS
BB65-RCC NYrKS4lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nHdGlEPTB;MD6wN|Y6OSEQvF2= MXPTRW5ITVJ?
BE-13 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTHbWtKSzVyPUCuNFM4PTlizszN MnyzV2FPT0WU
CP67-MEL NEDiXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzyV|VKSzVyPUCuNFM4PTlizszN NWHCWFhnW0GQR1XS
SW954 NFXtPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEO3PUDPxE1? M{LrZXNCVkeHUh?=
TE-5 NFTWZ5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfTTWM2OD1yLkCzPFU1KM7:TR?= MX\TRW5ITVJ?
HCE-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfldFZ4UUN3ME2wMlA{QDV3IN88US=> MWXTRW5ITVJ?
LC-1F M4H2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvYTWM2OD1yLkCzPVg6KM7:TR?= NIXzUZdUSU6JRWK=
TK10 NITYc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojLTWM2OD1yLkC0NFE6KM7:TR?= M2T5S3NCVkeHUh?=
SJSA-1 NWrJOHF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMESxPFgh|ryP NGPGWGRUSU6JRWK=
Daudi NGToWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfMfWVtUUN3ME2wMlA1OjJ3IN88US=> MV;TRW5ITVJ?
SW982 NHrOPIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHK[ZhOUUN3ME2wMlA1OjR4IN88US=> M1TXfnNCVkeHUh?=
SF126 NI\xTnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPSZVZKSzVyPUCuNFQ{PjFizszN NIDMTmxUSU6JRWK=
TE-15 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorsTWM2OD1yLkC0OFM2KM7:TR?= NI[4fIdUSU6JRWK=
COLO-684 MmHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;2TWM2OD1yLkC0OVYyKM7:TR?= NFjIeGZUSU6JRWK=
8-MG-BA NWrid5lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMES2Nlkh|ryP MmfRV2FPT0WU
NB13 Mn;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HaSWlEPTB;MD6wOFc4PiEQvF2= NX;6PYxrW0GQR1XS
HCC1599 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMES4O|kh|ryP NWHYdnZpW0GQR1XS
SK-PN-DW MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXmS214UUN3ME2wMlA1QTR7IN88US=> MnHaV2FPT0WU
ALL-PO M1[2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEixUlBKSzVyPUCuNFQ6PTZizszN NWT0eY5XW0GQR1XS
NB6 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[3SmhtUUN3ME2wMlA2OjdzIN88US=> MmXRV2FPT0WU
IST-SL2 NVvhTFhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCzbZlvUUN3ME2wMlA2OzZ{IN88US=> MkHVV2FPT0WU
BB30-HNC Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnTU4UzUUN3ME2wMlA2PzNizszN NIPVbo9USU6JRWK=
SW962 NInn[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;JVI5KSzVyPUCuNFU4PjNizszN MUfTRW5ITVJ?
TGBC24TKB NUnFUphET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPHRmh3UUN3ME2wMlA2Pzl7IN88US=> NXO1VVFoW0GQR1XS
KINGS-1 NYrzPHRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVizVHZ1UUN3ME2wMlA2QDB|IN88US=> NEPlSYdUSU6JRWK=
HC-1 NVzuU|dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXXTWM2OD1yLkC1PFI4KM7:TR?= NGLxSY9USU6JRWK=
RS4-11 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVy4eIpyUUN3ME2wMlA2QTN6IN88US=> NGXLW4NUSU6JRWK=
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LS-513 M4rMTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjSTWM2OD1yLkO5NFcyKM7:TR?= NUPIW29JW0GQR1XS
NOMO-1 NFzncFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwM{m5O|Eh|ryP NYHBWotKW0GQR1XS
MS-1 NFj3WW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSxR|hwUUN3ME2wMlQxOTd5IN88US=> M4fKXnNCVkeHUh?=
EKVX MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi5NZJZUUN3ME2wMlQ1PDZzIN88US=> M3LMSHNCVkeHUh?=
SK-MEL-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwNE[0JO69VQ>? MkHpV2FPT0WU
HCC1187 M1LRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3BTppKSzVyPUCuOFY4PjhizszN NXr4O3MxW0GQR1XS
HCC2218 NIjwcYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;JWIJOUUN3ME2wMlQ4OjJ5IN88US=> NHLLS2xUSU6JRWK=
NCI-H187 NF;IOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf5TWM2OD1yLkS3PFQh|ryP NI\ydlNUSU6JRWK=
DB NHuwTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHHTWM2OD1yLkWwNFU2KM7:TR?= NV\1Z|hDW0GQR1XS
NCI-H69 NFvjNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGzPXdJUUN3ME2wMlUxOjR5IN88US=> MWfTRW5ITVJ?
NCI-H1694 Ml\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm0TWM2OD1yLkWwOlk4KM7:TR?= NETteJBUSU6JRWK=
CA46 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\0UFBKSzVyPUCuOVA6OTdizszN M2nyNnNCVkeHUh?=
EHEB MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzudplKSzVyPUCuOVEyQTNizszN MXXTRW5ITVJ?
NCCIT M1f0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPhTWM2OD1yLkW0N|IyKM7:TR?= MlfKV2FPT0WU
NCI-H720 NGDXZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13UNGlEPTB;MD61OFk3OiEQvF2= NYLhc3A4W0GQR1XS
LU-134-A NF\NOFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwNUWyPVYh|ryP MUfTRW5ITVJ?
MC-CAR NEfs[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNUW0N|Eh|ryP MmrtV2FPT0WU
NEC8 NVeyV2lkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;1[4pNUUN3ME2wMlU3OTd{IN88US=> MlLZV2FPT0WU
NCI-H524 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn2yTWM2OD1yLkW4O|Q5KM7:TR?= M1fwXnNCVkeHUh?=
NCI-H1963 MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLTdYh2UUN3ME2wMlYzPThizszN MX\TRW5ITVJ?
SU-DHL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHBWJRmUUN3ME2wMlY1PTJ4IN88US=> NHTCXVVUSU6JRWK=
NCI-H1522 NYTzZo5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDmWZNKSzVyPUCuOlQ5QDNizszN NVvPOYY1W0GQR1XS
NCI-H1155 NXnrVFY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwNkWzOUDPxE1? MYHTRW5ITVJ?
D-263MG MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M136NGlEPTB;MD62OlExOSEQvF2= MVTTRW5ITVJ?
TE-6 MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwNkixNFQh|ryP NWTQZ5pJW0GQR1XS
NCI-H1417 M3fFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXkUnNKSzVyPUCuOlk4OTFizszN MmfDV2FPT0WU
NCI-H510A Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP3VZExUUN3ME2wMlc4OjN4IN88US=> MWfTRW5ITVJ?
KARPAS-45 NUnwb4o1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnpfWI4UUN3ME2wMlc5OjN3IN88US=> Ml:wV2FPT0WU
IST-SL1 NF22TlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvJTWM2OD1yLki1PFI2KM7:TR?= MlLOV2FPT0WU
COLO-824 NXLo[Wk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\HcYNKSzVyPUCuPFc5OzVizszN NVPyXoN[W0GQR1XS
NCI-H526 NH7JdIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;nTWM2OD1yLkmwPVU5KM7:TR?= MkjDV2FPT0WU
NCI-H719 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfUfoZKSzVyPUCuPVY3PTdizszN NUL6S4Z5W0GQR1XS
SF539 NY\XeYZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zvb2lEPTB;MD65PFM6PiEQvF2= MkfBV2FPT0WU
NKM-1 NGPleFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\ZWmlEPTB;MD65PFY3OyEQvF2= Mke3V2FPT0WU
A253 NFTTZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17qNGlEPTB;MD65PFg5PSEQvF2= NVjFepJTW0GQR1XS
TE-441-T MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3nN2tKSzVyPUGuNFQ{PSEQvF2= MV;TRW5ITVJ?
COR-L88 MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjSTWM2OD1zLkGxN|U1KM7:TR?= M4\tcnNCVkeHUh?=
CPC-N NFTzNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PueWlEPTB;MT6xOVg5QCEQvF2= M2rKdnNCVkeHUh?=
NCI-H2107 NITnOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETGUWxKSzVyPUGuNVczPjFizszN M1zlRnNCVkeHUh?=
ECC4 MlrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjZfXRKSzVyPUGuNVg3QTNizszN M1WwUnNCVkeHUh?=
NCI-H2141 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVe2Snd{UUN3ME2xMlE6Ojl7IN88US=> NVnKeZBGW0GQR1XS
NCI-H1770 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[yTWM2OD1zLkOyPVI5KM7:TR?= NXjZV244W0GQR1XS
NCI-SNU-1 NIHSe|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HX[WlEPTB;MT6zN|A1KM7:TR?= Mne5V2FPT0WU
LU-165 NXvz[2JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nCRWlEPTB;MT60OVQ3PyEQvF2= MnXEV2FPT0WU
Raji Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTsb4JKSzVyPUGuOFczPTlizszN M3;FOHNCVkeHUh?=
EW-24 NHGzclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrlWndKUUN3ME2xMlU1PjF7IN88US=> NV3mPXRlW0GQR1XS
KP-N-RT-BM-1 MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwNU[1OVEh|ryP MUHTRW5ITVJ?
SK-MEL-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTFwNkS4O|ch|ryP MUjTRW5ITVJ?
SCLC-21H NXfSUmlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnReGVTUUN3ME2xMlY3PjVzIN88US=> MXvTRW5ITVJ?
SIMA NHrMV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPoVFZKSzVyPUGuOlgzOzNizszN NF\KZ2hUSU6JRWK=
NCI-H1304 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnkfY9KSzVyPUGuO|A4PjVizszN M4fJ[nNCVkeHUh?=
REH MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfwPGhKSzVyPUGuO|ExPzhizszN M1TTXHNCVkeHUh?=
KP-N-YS M4LvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYruUZR2UUN3ME2xMlk{PTVzIN88US=> MoeyV2FPT0WU
DMS-153 NH7yPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\DXmdKSzVyPUGuPVc2QSEQvF2= MXHTRW5ITVJ?
NB10 Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;ldmlEPTB;Mj6yNFg4QCEQvF2= MnG0V2FPT0WU
NCI-H345 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DPSWlEPTB;Mj62NVkxPSEQvF2= MXLTRW5ITVJ?
SK-N-FI NF;BPG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\3TWM2OD1{Lke1N|gyKM7:TR?= NULzOmptW0GQR1XS
NCI-H1092 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnUTWM2OD1{Lkm1N|k1KM7:TR?= MkPIV2FPT0WU
KM-H2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rPS2lEPTB;Mz62OVM6PiEQvF2= MYfTRW5ITVJ?
KG-1 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;WNnBKSzVyPUOuO|E3QDhizszN MkjHV2FPT0WU
D-283MED NV3HN4FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPGTWM2OD1|Lke1PFch|ryP MnfXV2FPT0WU
LU-65 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTRwMUG0PFUh|ryP MX3TRW5ITVJ?
MSTO-211H MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTRwMUi4PVgh|ryP MYfTRW5ITVJ?
NCI-H2081 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorSTWM2OD12LkK5NVc1KM7:TR?= MWjTRW5ITVJ?
D-247MG M{jQZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fITmlEPTB;ND60N|E6OSEQvF2= NV\yeIh6W0GQR1XS
P31-FUJ NGT2Nm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\rTWM2OD12LkS1NFE6KM7:TR?= M4nHN3NCVkeHUh?=
DMS-79 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP3TWM2OD12LkmzNVg{KM7:TR?= M{CzZXNCVkeHUh?=
KASUMI-1 MknpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPG[ndLUUN3ME20Mlk4PTB7IN88US=> MXPTRW5ITVJ?
JVM-3 NUnoSGhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTVwMkWwNVQh|ryP MX;TRW5ITVJ?
LAN-6 Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3izU2lEPTB;NT61NVc{PiEQvF2= MorvV2FPT0WU
DJM-1 M4POR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzoTWM2OD13LkW2NFI6KM7:TR?= MW\TRW5ITVJ?
JVM-2 NVfEcpNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq4dXFKSzVyPUWuOlcxQTJizszN NHPQSHpUSU6JRWK=
U-87-MG NFHVeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmxXYhKSzVyPUWuPFk6PjRizszN MYrTRW5ITVJ?
SHP-77 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTRTWM2OD13Lkm0PVI5KM7:TR?= MnewV2FPT0WU
RPMI-8866 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXMdGJKSzVyPU[uNlcxOTNizszN NXLuSG1LW0GQR1XS
ES7 M3nBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTZwM{m5NlQh|ryP NHL5[25USU6JRWK=
WSU-NHL MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDkXZdKSzVyPU[uOVE3ODlizszN NWLOUYo3W0GQR1XS
CAS-1 Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTdwMEm3OFkh|ryP M3nxc3NCVkeHUh?=
MHH-NB-11 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnF[2ZjUUN3ME24MlI{OTV{IN88US=> MXnTRW5ITVJ?
ES5 M4X3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrqUVlxUUN3ME25MlUzOjh4IN88US=> NHLhNppUSU6JRWK=
HDLM-2 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3GemxKSzVyPUmuPVU6ODJizszN NVuzNYMyW0GQR1XS
NCI-H2171 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTTTWM2OD1zMD61PVI4KM7:TR?= MX\TRW5ITVJ?
LNCaP-Clone-FGC MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojtTWM2OD1zMT6zO|E5KM7:TR?= MVnTRW5ITVJ?
NCI-H1395 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jTUWlEPTB;MUKuNlY6QSEQvF2= NX\qOm9IW0GQR1XS
NCI-H1436 M1HRVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXUTWM2OD1zMz6zNVk2KM7:TR?= MXfTRW5ITVJ?
RCC10RGB NHzlO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf4TWM2OD1zMz6zNlIyKM7:TR?= M3nGcXNCVkeHUh?=
SW684 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nXUGlEPTB;MUOuPVc6PyEQvF2= M1nlTXNCVkeHUh?=
NCI-H1650 M2jsemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO2eldDUUN3ME2xOU4xPDR5IN88US=> MVXTRW5ITVJ?
EW-13 NFTOPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF3LkKwNlEh|ryP NGrmeGlUSU6JRWK=
EC-GI-10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP2S2JKSzVyPUG1Mlg3PDRizszN NYPTT4l[W0GQR1XS
CHP-126 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S5dmlEPTB;MUeuNVkyQCEQvF2= NX;S[ZlyW0GQR1XS
NCI-H226 NFLCbppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnHfnlKSzVyPUG4MlA1ODNizszN NEXVSJhUSU6JRWK=
NCI-H1838 NYLWOIFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrrV4ZQUUN3ME2yNE4yQDR6IN88US=> MYTTRW5ITVJ?
EW-11 M{H4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLpfIdMUUN3ME2yOE4zPzF6IN88US=> NIT2do9USU6JRWK=
EB2 NUfk[5RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG1U3J7UUN3ME2zNU42OzF6IN88US=> NWLPWIVvW0GQR1XS
D-502MG NIrXcIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmxVIxTUUN3ME20N{46OjJ7IN88US=> NF:3bFdUSU6JRWK=
U-698-M MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rmV2lEPTB;NEiuPFY4OSEQvF2= M4rFRnNCVkeHUh?=
ES3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnqcYNSUUN3ME20PU4{QDl|IN88US=> MUPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID