Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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Cited by 11 Publications

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  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 M3nHSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv1dmNKSzVyPUCuNFAxOzB4IN88US=> NEDwfW5USU6JRWK=
OCUB-M NGfROlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzPW|lKSzVyPUCuNFAyQTRizszN M1fTd3NCVkeHUh?=
DOHH-2 NGPrUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMECyNlUh|ryP NVfKc3J2W0GQR1XS
NOS-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnWZY9KSzVyPUCuNFAzPDJizszN NYXDWog6W0GQR1XS
L-363 NGDOToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMECyPFQh|ryP NI\VXWdUSU6JRWK=
RL95-2 M1\u[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnkPJRjUUN3ME2wMlAxOzJizszN NFfRWYZUSU6JRWK=
BL-70 NUXJXnlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33iZmlEPTB;MD6wNFM{PyEQvF2= MnXNV2FPT0WU
TGBC1TKB Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrOTWM2OD1yLkCwN|c6KM7:TR?= NEewTmFUSU6JRWK=
697 MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\oO3NYUUN3ME2wMlAxPjN2IN88US=> M2LMfnNCVkeHUh?=
RPMI-8226 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPpO5FKSzVyPUCuNFA3PTFizszN NHjt[VdUSU6JRWK=
BL-41 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H4SWlEPTB;MD6wNFY6PiEQvF2= MlraV2FPT0WU
MRK-nu-1 NYDQNJVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEC3NFch|ryP NUXlTJhbW0GQR1XS
EW-1 NX7OVm5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q5TWlEPTB;MD6wNFc1QSEQvF2= NILCW4tUSU6JRWK=
EVSA-T M{O5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfjNJF[UUN3ME2wMlAxQDl{IN88US=> M2m4S3NCVkeHUh?=
HUTU-80 NEnxOXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\mfWlEPTB;MD6wNFkzQSEQvF2= MX\TRW5ITVJ?
VA-ES-BJ MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHETWM2OD1yLkCwPVg1KM7:TR?= M3uwe3NCVkeHUh?=
GCIY Mn;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPOTWM2OD1yLkCxNFA4KM7:TR?= MlPsV2FPT0WU
ES6 NFPhOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHHdYNSUUN3ME2wMlAyODh|IN88US=> MkfkV2FPT0WU
NALM-6 NGLW[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoriTWM2OD1yLkCxNVAzKM7:TR?= NIrHeIlUSU6JRWK=
LB996-RCC M2rl[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMEGxN|ch|ryP M2m3dnNCVkeHUh?=
EW-16 M3jsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDGXGJKSzVyPUCuNFEyQTJizszN NIf6TXNUSU6JRWK=
KALS-1 MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXyW2dKSzVyPUCuNFEyQThizszN NWrGdGFHW0GQR1XS
OPM-2 NWH6NoJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEGyPUDPxE1? MVPTRW5ITVJ?
KU812 M4eyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HlN2lEPTB;MD6wNVI6PiEQvF2= MYfTRW5ITVJ?
A4-Fuk MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[xO2lEPTB;MD6wNVMyQSEQvF2= MkX3V2FPT0WU
KGN NIOxb21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjWcoJKSzVyPUCuNFE{PTlizszN NELHfpVUSU6JRWK=
KS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICwb5lKSzVyPUCuNFE{QTJizszN M4[2VnNCVkeHUh?=
no-11 NUHzO|lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrpS4lKSzVyPUCuNFE{QTVizszN MlO0V2FPT0WU
PSN1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMEG0NFkh|ryP NFrIdndUSU6JRWK=
SK-LMS-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfuTWM2OD1yLkCxOFE{KM7:TR?= MVrTRW5ITVJ?
LS-411N M{fO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rle2lEPTB;MD6wNVQ{QSEQvF2= NVXmWZZJW0GQR1XS
HT-144 MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfjTWM2OD1yLkCxOFUyKM7:TR?= NU\0[ZI2W0GQR1XS
ACN NU[w[XRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37KcGlEPTB;MD6wNVUh|ryP NFTVXGpUSU6JRWK=
RKO Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm2V2tKSzVyPUCuNFE2OzNizszN NIriSWJUSU6JRWK=
CMK MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjKTWM2OD1yLkCxOVQ{KM7:TR?= NEDVWYtUSU6JRWK=
GB-1 NX3GUo57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[wN|JKSzVyPUCuNFE2PTNizszN MnTIV2FPT0WU
KE-37 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vPWGlEPTB;MD6wNVU4OyEQvF2= NXfZNJJTW0GQR1XS
no-10 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnM[JB7UUN3ME2wMlAyPTh2IN88US=> MnzCV2FPT0WU
MOLT-16 M1m4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHpNnpKSzVyPUCuNFE3OjJizszN NELNSYdUSU6JRWK=
HEL M2nBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jRVWlEPTB;MD6wNVY1KM7:TR?= M1XZVXNCVkeHUh?=
NCI-H1355 NX:wXHBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvDTWM2OD1yLkCxOlQ3KM7:TR?= M3PyTXNCVkeHUh?=
IST-MEL1 MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvqN5hKSzVyPUCuNFE4PzRizszN NGXIWWxUSU6JRWK=
MHH-PREB-1 NXS0cZlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDGUmV3UUN3ME2wMlAyQDF6IN88US=> NFTETmNUSU6JRWK=
ES8 NYHEe4dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDmS4lKSzVyPUCuNFE5PDRizszN M33afnNCVkeHUh?=
LC-2-ad NVjqOml1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXodFVkUUN3ME2wMlAzOTN5IN88US=> MVnTRW5ITVJ?
LAMA-84 NVr1RopNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDKTWM2OD1yLkCyNVY4KM7:TR?= M1Lu[HNCVkeHUh?=
BV-173 NFPObHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfRTWM2OD1yLkCyNlA{KM7:TR?= MoLZV2FPT0WU
SW872 M2j0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH3b3R{UUN3ME2wMlAzOjR5IN88US=> M4\ydHNCVkeHUh?=
SK-UT-1 NYrVTnlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfJOmZHUUN3ME2wMlAzOjZzIN88US=> MlTFV2FPT0WU
OS-RC-2 NHXmeoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPiVnFKSzVyPUCuNFI{OjNizszN MkD5V2FPT0WU
NCI-H747 NVXaeHk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ewbGlEPTB;MD6wNlM{KM7:TR?= MX\TRW5ITVJ?
MZ2-MEL NIrPe5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjHXWNsUUN3ME2wMlAzOzN5IN88US=> M2XMV3NCVkeHUh?=
TE-11 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzBe21KSzVyPUCuNFI{PzJizszN MUHTRW5ITVJ?
KURAMOCHI M{LuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPwWXZKSzVyPUCuNFI1OTRizszN MWfTRW5ITVJ?
HD-MY-Z MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ITWM2OD1yLkCyOFI3KM7:TR?= MYrTRW5ITVJ?
GI-1 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D3WWlEPTB;MD6wNlQ3QSEQvF2= MV;TRW5ITVJ?
LB1047-RCC M3WyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;aTWM2OD1yLkCyOFg5KM7:TR?= MmXIV2FPT0WU
TE-12 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[wRmlEPTB;MD6wNlU2KM7:TR?= MojEV2FPT0WU
MZ7-mel NWm4XFZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3NTWM2OD1yLkCyOlA6KM7:TR?= NEPRTHhUSU6JRWK=
MMAC-SF MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMEK2N|Mh|ryP MUnTRW5ITVJ?
A101D M3rtS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEK2OUDPxE1? NGqwfGNUSU6JRWK=
GR-ST MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHnTWM2OD1yLkCyOlU2KM7:TR?= MY\TRW5ITVJ?
MC116 MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEK2PEDPxE1? MnPCV2FPT0WU
Ramos-2G6-4C10 M{HjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDCNmxKSzVyPUCuNFI4PSEQvF2= MlHxV2FPT0WU
ATN-1 M2DTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vBW2lEPTB;MD6wNlc5QSEQvF2= NH20UYFUSU6JRWK=
MFH-ino MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPDRZd{UUN3ME2wMlAzQDF{IN88US=> Ml;QV2FPT0WU
DEL NI\3XpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEK4NVUh|ryP NX;yeJRlW0GQR1XS
OCI-AML2 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfSTWM2OD1yLkCyPFcyKM7:TR?= NX\Fb5hlW0GQR1XS
LXF-289 Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrjS49kUUN3ME2wMlAzQDd{IN88US=> NHnWWWJUSU6JRWK=
IA-LM MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XXXGlEPTB;MD6wNlkyPyEQvF2= MVrTRW5ITVJ?
EoL-1-cell M{PNWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXlRVdKSzVyPUCuNFI6QTZizszN NV\JfW9vW0GQR1XS
OVCAR-4 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL3Oo9QUUN3ME2wMlA{ODl2IN88US=> NYTxblQ4W0GQR1XS
ES1 NFu2OoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrBTWM2OD1yLkCzNFk4KM7:TR?= M{TYRXNCVkeHUh?=
CESS M3PXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPjR2hKSzVyPUCuNFMxQTlizszN NF\LPYVUSU6JRWK=
GAK Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEOxPFYh|ryP Mk\WV2FPT0WU
NTERA-S-cl-D1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknVTWM2OD1yLkCzNlI3KM7:TR?= MVLTRW5ITVJ?
TE-10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEOzNVEh|ryP NVfzNYo1W0GQR1XS
CCRF-CEM NVX4U5dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXSbZg{UUN3ME2wMlA{OzdzIN88US=> NGLaUplUSU6JRWK=
NMC-G1 M16xO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqyRYdKSzVyPUCuNFM1PDhizszN MXvTRW5ITVJ?
HOP-62 NX;wNHhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofETWM2OD1yLkCzOVU3KM7:TR?= NInKUVVUSU6JRWK=
SH-4 NGH0UG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW0N3JRUUN3ME2wMlA{PTh{IN88US=> M4nqeXNCVkeHUh?=
NCI-H1648 NHzMUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH4OoY3UUN3ME2wMlA{PjJ{IN88US=> NFTqcGdUSU6JRWK=
EB-3 M17nNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLqTWM2OD1yLkCzOlQ{KM7:TR?= M4[5[XNCVkeHUh?=
BB65-RCC NHPO[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLwTWM2OD1yLkCzOlkyKM7:TR?= MkPZV2FPT0WU
BE-13 Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP4TWM2OD1yLkCzO|U6KM7:TR?= MW\TRW5ITVJ?
CP67-MEL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XpTWlEPTB;MD6wN|c2QSEQvF2= MX\TRW5ITVJ?
SW954 NYKyTVNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrkd4JKSzVyPUCuNFM4QSEQvF2= MVnTRW5ITVJ?
TE-5 NFqwTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;YTmRKSzVyPUCuNFM5PTRizszN NVHCNFRoW0GQR1XS
HCE-4 NWnnPFhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS2bXJ3UUN3ME2wMlA{QDV3IN88US=> NWTZVGxCW0GQR1XS
LC-1F NXWyTXN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37hbGlEPTB;MD6wN|k5QSEQvF2= MmPBV2FPT0WU
TK10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL6PZZKSzVyPUCuNFQxOTlizszN MnPJV2FPT0WU
SJSA-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r1N2lEPTB;MD6wOFE5QCEQvF2= M3zWTnNCVkeHUh?=
Daudi MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe5RYZmUUN3ME2wMlA1OjJ3IN88US=> MUDTRW5ITVJ?
SW982 NW\tWWZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PEZmlEPTB;MD6wOFI1PiEQvF2= MmPPV2FPT0WU
SF126 NVTuZ4VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMESzOlEh|ryP MX3TRW5ITVJ?
TE-15 NUPSXpZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjmZpJKSzVyPUCuNFQ1OzVizszN NYDZfY9CW0GQR1XS
COLO-684 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XVTWlEPTB;MD6wOFU3OSEQvF2= NXPt[5I3W0GQR1XS
8-MG-BA NHrxVIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fydmlEPTB;MD6wOFYzQSEQvF2= MlnHV2FPT0WU
NB13 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\teWlEPTB;MD6wOFc4PiEQvF2= MVzTRW5ITVJ?
HCC1599 NVj6eIs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMES4O|kh|ryP Mof4V2FPT0WU
SK-PN-DW MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMES5OFkh|ryP MXzTRW5ITVJ?
ALL-PO MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTKT5lHUUN3ME2wMlA1QTV4IN88US=> NGTSbI1USU6JRWK=
NB6 NWm5S4w6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3joW2lEPTB;MD6wOVI4OSEQvF2= NILMXYZUSU6JRWK=
IST-SL2 M3izRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmflTWM2OD1yLkC1N|YzKM7:TR?= NITmXJNUSU6JRWK=
BB30-HNC NFLmeZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTlbItKSzVyPUCuNFU4OyEQvF2= MWDTRW5ITVJ?
SW962 M{G0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHUVnRKSzVyPUCuNFU4PjNizszN NGXiV25USU6JRWK=
TGBC24TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fCPGlEPTB;MD6wOVc6QSEQvF2= M{nMPXNCVkeHUh?=
KINGS-1 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEW4NFMh|ryP Mk[3V2FPT0WU
HC-1 M1f6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjLOmRKSzVyPUCuNFU5OjdizszN NIHCOZNUSU6JRWK=
RS4-11 M3jlW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEW5N|gh|ryP MVrTRW5ITVJ?
LS-123 M2XRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzJd5U6UUN3ME2wMlA2QTR{IN88US=> NGDBbI1USU6JRWK=
A3-KAW NX3yRZBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nqTWlEPTB;MD6wOlIzPSEQvF2= MkTSV2FPT0WU
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NOMO-1 M3m5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLhTWM2OD1yLkO5PVcyKM7:TR?= NVfqXYFxW0GQR1XS
MS-1 NXTZc2lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorjTWM2OD1yLkSwNVc4KM7:TR?= M4LUcnNCVkeHUh?=
EKVX MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PxeGlEPTB;MD60OFQ3OSEQvF2= MoDzV2FPT0WU
SK-MEL-2 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PoOGlEPTB;MD60OlQh|ryP NYPxVVQ6W0GQR1XS
HCC1187 NHOycVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLYXXhmUUN3ME2wMlQ3PzZ6IN88US=> NUm4[2NsW0GQR1XS
HCC2218 NYjPdJplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHNTY9KSzVyPUCuOFczOjdizszN MkLyV2FPT0WU
NCI-H187 NH\3[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfqTWM2OD1yLkS3PFQh|ryP NUP4boZuW0GQR1XS
DB MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwNUCwOVUh|ryP NXe0SWM2W0GQR1XS
NCI-H69 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi1TWM2OD1yLkWwNlQ4KM7:TR?= MnmwV2FPT0WU
NCI-H1694 MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DvNWlEPTB;MD61NFY6PyEQvF2= M2HvWnNCVkeHUh?=
CA46 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3FOmpKSzVyPUCuOVA6OTdizszN NHXmZYJUSU6JRWK=
EHEB NYnte5M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXNbnZKSzVyPUCuOVEyQTNizszN M3fwUHNCVkeHUh?=
NCCIT MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3WTWM2OD1yLkW0N|IyKM7:TR?= MnLDV2FPT0WU
NCI-H720 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f0cWlEPTB;MD61OFk3OiEQvF2= NEj2SGFUSU6JRWK=
LU-134-A MoDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSzV3k4UUN3ME2wMlU2Ojl4IN88US=> M4LX[nNCVkeHUh?=
MC-CAR MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXyc5ZKSzVyPUCuOVU1OzFizszN NXnDVHl2W0GQR1XS
NEC8 NFHTU2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHITmxKSzVyPUCuOVYyPzJizszN Ml;DV2FPT0WU
NCI-H524 M1:3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwNUi3OFgh|ryP NFm3PXdUSU6JRWK=
NCI-H1963 M4j0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD3TWM2OD1yLk[yOVgh|ryP NWDUUINEW0GQR1XS
SU-DHL-1 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwNkS1NlYh|ryP NHjB[JRUSU6JRWK=
NCI-H1522 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwNkS4PFMh|ryP Mon6V2FPT0WU
NCI-H1155 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNkWzOUDPxE1? NFHJbWZUSU6JRWK=
D-263MG NXn5eFBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLJ[253UUN3ME2wMlY3OTBzIN88US=> NV76OI1QW0GQR1XS
TE-6 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17ubWlEPTB;MD62PFExPCEQvF2= NGP5Om5USU6JRWK=
NCI-H1417 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13idmlEPTB;MD62PVcyOSEQvF2= MmHVV2FPT0WU
NCI-H510A NXLRV2djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTCTWM2OD1yLke3NlM3KM7:TR?= MV;TRW5ITVJ?
KARPAS-45 M{Kw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjHUlRmUUN3ME2wMlc5OjN3IN88US=> MmDHV2FPT0WU
IST-SL1 Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfRWoRjUUN3ME2wMlg2QDJ3IN88US=> MXvTRW5ITVJ?
COLO-824 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTsTWM2OD1yLki3PFM2KM7:TR?= NY\iW2RKW0GQR1XS
NCI-H526 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\MTWM2OD1yLkmwPVU5KM7:TR?= MWHTRW5ITVJ?
NCI-H719 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDOWo5KSzVyPUCuPVY3PTdizszN NYDQOGlXW0GQR1XS
SF539 Mn;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPz[IFyUUN3ME2wMlk5Ozl4IN88US=> MXHTRW5ITVJ?
NKM-1 M3vPS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjTcIptUUN3ME2wMlk5PjZ|IN88US=> NEHKfFlUSU6JRWK=
A253 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrKd41KSzVyPUCuPVg5QDVizszN NHTZfJJUSU6JRWK=
TE-441-T Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TGeWlEPTB;MT6wOFM2KM7:TR?= M1S2N3NCVkeHUh?=
COR-L88 NHPFW|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ridGlEPTB;MT6xNVM2PCEQvF2= M4mzfXNCVkeHUh?=
CPC-N M2XNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3DTolKSzVyPUGuNVU5QDhizszN MoPyV2FPT0WU
NCI-H2107 NVzMNWFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO1PXFVUUN3ME2xMlE4OjZzIN88US=> NV7aTJZoW0GQR1XS
ECC4 NIfQXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u0fGlEPTB;MT6xPFY6OyEQvF2= M4n6eHNCVkeHUh?=
NCI-H2141 NVLmenJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fFVmlEPTB;MT6xPVI6QSEQvF2= NYC2dlRkW0GQR1XS
NCI-H1770 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13IXmlEPTB;MT6zNlkzQCEQvF2= MmGxV2FPT0WU
NCI-SNU-1 NEPKPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrFR|RQUUN3ME2xMlM{ODRizszN NHfsPXNUSU6JRWK=
LU-165 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFwNEW0Olch|ryP NYHNTWJKW0GQR1XS
Raji MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rTc2lEPTB;MT60O|I2QSEQvF2= MXnTRW5ITVJ?
EW-24 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXh[ZZKSzVyPUGuOVQ3OTlizszN MlvvV2FPT0WU
KP-N-RT-BM-1 NXvYVJQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUiwTYo4UUN3ME2xMlU3PTVzIN88US=> MVHTRW5ITVJ?
SK-MEL-1 MlzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvtTWM2OD1zLk[0PFc4KM7:TR?= MVHTRW5ITVJ?
SCLC-21H MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS4R3BUUUN3ME2xMlY3PjVzIN88US=> M2LhdXNCVkeHUh?=
SIMA MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW1O2Z2UUN3ME2xMlY5OjN|IN88US=> MWHTRW5ITVJ?
NCI-H1304 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle2TWM2OD1zLkewO|Y2KM7:TR?= MnP6V2FPT0WU
REH Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fW[2lEPTB;MT63NVA4QCEQvF2= NGmzXY1USU6JRWK=
KP-N-YS Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrHTG9KSzVyPUGuPVM2PTFizszN MYDTRW5ITVJ?
DMS-153 M{LJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL1c|VvUUN3ME2xMlk4PTlizszN MmLnV2FPT0WU
NB10 NF75ZVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HncmlEPTB;Mj6yNFg4QCEQvF2= MXrTRW5ITVJ?
NCI-H345 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\TTWM2OD1{Lk[xPVA2KM7:TR?= NWPSSlZOW0GQR1XS
SK-N-FI NXv2UXN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PJfmlEPTB;Mj63OVM5OSEQvF2= MmrsV2FPT0WU
NCI-H1092 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDuTWM2OD1{Lkm1N|k1KM7:TR?= MWXTRW5ITVJ?
KM-H2 NEnIcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT2TWM2OD1|Lk[1N|k3KM7:TR?= MY\TRW5ITVJ?
KG-1 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXaTWM2OD1|LkexOlg5KM7:TR?= M3jqVHNCVkeHUh?=
D-283MED MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNwN{W4O{DPxE1? M3vic3NCVkeHUh?=
LU-65 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;sU|dTUUN3ME20MlEyPDh3IN88US=> M3r2bHNCVkeHUh?=
MSTO-211H NF;FTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPYUm9lUUN3ME20MlE5QDl6IN88US=> NVnCclRvW0GQR1XS
NCI-H2081 NF:ySXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M130fWlEPTB;ND6yPVE4PCEQvF2= NWW4XHNsW0GQR1XS
D-247MG Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTRwNEOxPVEh|ryP Ml2xV2FPT0WU
P31-FUJ NYHNW|IxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF61empKSzVyPUSuOFUxOTlizszN NXPOTJVbW0GQR1XS
DMS-79 M1HOR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rE[GlEPTB;ND65N|E5OyEQvF2= NHGxW4hUSU6JRWK=
KASUMI-1 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTJTWM2OD12Lkm3OVA6KM7:TR?= NHv4fJNUSU6JRWK=
JVM-3 MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDzTWM2OD13LkK1NFE1KM7:TR?= NXXSeJFLW0GQR1XS
LAN-6 NX7tTlIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof1TWM2OD13LkWxO|M3KM7:TR?= M1fBc3NCVkeHUh?=
DJM-1 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrCc5FHUUN3ME21MlU3ODJ7IN88US=> MWHTRW5ITVJ?
JVM-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjmeIo1UUN3ME21MlY4ODl{IN88US=> MUDTRW5ITVJ?
U-87-MG MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTVwOEm5OlQh|ryP M1rHNnNCVkeHUh?=
SHP-77 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\6WnpKSzVyPUWuPVQ6OjhizszN Mon5V2FPT0WU
RPMI-8866 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTZwMkewNVMh|ryP NGe4VJVUSU6JRWK=
ES7 NHjU[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fsTWlEPTB;Nj6zPVkzPCEQvF2= NEHMWFBUSU6JRWK=
WSU-NHL M1;N[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2wUmo2UUN3ME22MlUyPjB7IN88US=> M1Ky[3NCVkeHUh?=
CAS-1 NGDsPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlK0TWM2OD15LkC5O|Q6KM7:TR?= Mo[wV2FPT0WU
MHH-NB-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTzTWM2OD16LkKzNVUzKM7:TR?= M1GxOXNCVkeHUh?=
ES5 NVPWbpVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTlwNUKyPFYh|ryP MVTTRW5ITVJ?
HDLM-2 NYfaeYo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLwT2FKSzVyPUmuPVU6ODJizszN NELS[FhUSU6JRWK=
NCI-H2171 NGe0U5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK5TWM2OD1zMD61PVI4KM7:TR?= M{KyWXNCVkeHUh?=
LNCaP-Clone-FGC NIfwb21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX75eW9iUUN3ME2xNU4{PzF6IN88US=> MYXTRW5ITVJ?
NCI-H1395 NWm0cWwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{X2RWlEPTB;MUKuNlY6QSEQvF2= NUHOOIxQW0GQR1XS
NCI-H1436 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF|LkOxPVUh|ryP NEfOUWtUSU6JRWK=
RCC10RGB MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jTWGlEPTB;MUOuN|IzOSEQvF2= MmjHV2FPT0WU
SW684 MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm1TWM2OD1zMz65O|k4KM7:TR?= MmDMV2FPT0WU
NCI-H1650 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M125R2lEPTB;MUWuNFQ1PyEQvF2= NHXOWHJUSU6JRWK=
EW-13 M17GfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX6TWM2OD1zNT6yNFIyKM7:TR?= MonIV2FPT0WU
EC-GI-10 M17TN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TY[GlEPTB;MUWuPFY1PCEQvF2= NHq1VlBUSU6JRWK=
CHP-126 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELI[4FKSzVyPUG3MlE6OThizszN NEX4UWNUSU6JRWK=
NCI-H226 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTvTWM2OD1zOD6wOFA{KM7:TR?= NILvVZNUSU6JRWK=
NCI-H1838 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjxRXdIUUN3ME2yNE4yQDR6IN88US=> M1PX[nNCVkeHUh?=
EW-11 NF7YfmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzJe3A1UUN3ME2yOE4zPzF6IN88US=> M{fZ[nNCVkeHUh?=
EB2 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfNOmUzUUN3ME2zNU42OzF6IN88US=> NVLTO4tbW0GQR1XS
D-502MG MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj4R2dSUUN3ME20N{46OjJ7IN88US=> NX3XZ4p2W0GQR1XS
U-698-M MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXUTWM2OD12OD64OlcyKM7:TR?= NUTSUJV7W0GQR1XS
ES3 NILUOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nxWWlEPTB;NEmuN|g6OyEQvF2= MkTrV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID