Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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5 Customer Reviews

  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Lw[WlEPTB;MD6wNFA{ODZizszN M2PPR3NCVkeHUh?=
OCUB-M NV7TPXhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13IcmlEPTB;MD6wNFE6PCEQvF2= NVXKPZVbW0GQR1XS
DOHH-2 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj6XVJKSzVyPUCuNFAzOjVizszN NVvkfIZUW0GQR1XS
NOS-1 M4\2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;3U4I2UUN3ME2wMlAxOjR{IN88US=> NUjHbVlTW0GQR1XS
L-363 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2D1emlEPTB;MD6wNFI5PCEQvF2= MXzTRW5ITVJ?
RL95-2 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPGTWM2OD1yLkCwN|Ih|ryP NGnROoFUSU6JRWK=
BL-70 NYjqNnhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M135WGlEPTB;MD6wNFM{PyEQvF2= MojxV2FPT0WU
TGBC1TKB NIjPemhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zne2lEPTB;MD6wNFM4QSEQvF2= M2LYUnNCVkeHUh?=
697 MknhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXRfYZKSzVyPUCuNFA3OzRizszN M3Lrc3NCVkeHUh?=
RPMI-8226 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;TVGNbUUN3ME2wMlAxPjVzIN88US=> MnnlV2FPT0WU
BL-41 NUfE[VYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEC2PVYh|ryP MVPTRW5ITVJ?
MRK-nu-1 M2PVfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEC3NFch|ryP MojvV2FPT0WU
EW-1 NWiz[mo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUna[|dXUUN3ME2wMlAxPzR7IN88US=> NYnMOW9tW0GQR1XS
EVSA-T Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmxU5o1UUN3ME2wMlAxQDl{IN88US=> M{XlWnNCVkeHUh?=
HUTU-80 M2HvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:4TWM2OD1yLkCwPVI6KM7:TR?= NH:y[2tUSU6JRWK=
VA-ES-BJ MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlyyTWM2OD1yLkCwPVg1KM7:TR?= MWrTRW5ITVJ?
GCIY NILRdnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITMZ5JKSzVyPUCuNFExODdizszN MUjTRW5ITVJ?
ES6 NXHvZ3VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEGwPFMh|ryP MWPTRW5ITVJ?
NALM-6 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P6dGlEPTB;MD6wNVExOiEQvF2= NVfVWnpGW0GQR1XS
LB996-RCC M1;OPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTkSplKSzVyPUCuNFEyOzdizszN MlSxV2FPT0WU
EW-16 NWnvb5FIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\FXGlEPTB;MD6wNVE6OiEQvF2= MVLTRW5ITVJ?
KALS-1 M{nnbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Pnb2lEPTB;MD6wNVE6QCEQvF2= NFrqNHBUSU6JRWK=
OPM-2 NEnzOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnWTWM2OD1yLkCxNlkh|ryP NGS4R3JUSU6JRWK=
KU812 NWfFRYkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXZdY5lUUN3ME2wMlAyOjl4IN88US=> M1OwfXNCVkeHUh?=
A4-Fuk M3vZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LQR2lEPTB;MD6wNVMyQSEQvF2= NH:2NlVUSU6JRWK=
KGN MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXVOYk{UUN3ME2wMlAyOzV7IN88US=> NXLZc2VmW0GQR1XS
KS-1 MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEGzPVIh|ryP NH3GZ4FUSU6JRWK=
no-11 NEPmR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LCRmlEPTB;MD6wNVM6PSEQvF2= NGfBVIFUSU6JRWK=
PSN1 M{fqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXkTWM2OD1yLkCxOFA6KM7:TR?= M2j2R3NCVkeHUh?=
SK-LMS-1 NXLrbXdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDJTJdKSzVyPUCuNFE1OTNizszN NIjEN|lUSU6JRWK=
LS-411N NHyyV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLzfXE2UUN3ME2wMlAyPDN7IN88US=> NHWwO41USU6JRWK=
HT-144 MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEG0OVEh|ryP NYe1R2VxW0GQR1XS
ACN NGjBR5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfKT5lPUUN3ME2wMlAyPSEQvF2= MXfTRW5ITVJ?
RKO NIGwWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXPdI9KSzVyPUCuNFE2OzNizszN M1PNXnNCVkeHUh?=
CMK M1TTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTuTWM2OD1yLkCxOVQ{KM7:TR?= NGexOIZUSU6JRWK=
GB-1 NEHRbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D4[GlEPTB;MD6wNVU2OyEQvF2= MoTSV2FPT0WU
KE-37 NHHZXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf5TWM2OD1yLkCxOVc{KM7:TR?= NEDjRWRUSU6JRWK=
no-10 NX65OXpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDsR5NKSzVyPUCuNFE2QDRizszN MU\TRW5ITVJ?
MOLT-16 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S1[GlEPTB;MD6wNVYzOiEQvF2= NX3NcGZuW0GQR1XS
HEL Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nUNWlEPTB;MD6wNVY1KM7:TR?= M2rYS3NCVkeHUh?=
NCI-H1355 MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjOZW97UUN3ME2wMlAyPjR4IN88US=> MoH5V2FPT0WU
IST-MEL1 Mm\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7wUGRkUUN3ME2wMlAyPzd2IN88US=> M17wTXNCVkeHUh?=
MHH-PREB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXztfHlvUUN3ME2wMlAyQDF6IN88US=> M4OyV3NCVkeHUh?=
ES8 NHL6TGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\EbHF1UUN3ME2wMlAyQDR2IN88US=> M{jPUHNCVkeHUh?=
LC-2-ad NEW5b3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX4[WFtUUN3ME2wMlAzOTN5IN88US=> M12z[nNCVkeHUh?=
LAMA-84 NVW2RVRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjRPHBKSzVyPUCuNFIyPjdizszN NH;rb4NUSU6JRWK=
BV-173 NYHkbG1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPGT3BKSzVyPUCuNFIzODNizszN NX73TGFKW0GQR1XS
SW872 MkTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[wTWM2OD1yLkCyNlQ4KM7:TR?= MUDTRW5ITVJ?
SK-UT-1 MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\UZmlKSzVyPUCuNFIzPjFizszN MkHkV2FPT0WU
OS-RC-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMEKzNlMh|ryP M1LJUXNCVkeHUh?=
NCI-H747 M{fxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKzN{DPxE1? NXf2O4FsW0GQR1XS
MZ2-MEL MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DUUWlEPTB;MD6wNlM{PyEQvF2= MmjkV2FPT0WU
TE-11 MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X3O2lEPTB;MD6wNlM4OiEQvF2= M3HtPXNCVkeHUh?=
KURAMOCHI M1:2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7VSJJqUUN3ME2wMlAzPDF2IN88US=> NVfLe|l[W0GQR1XS
HD-MY-Z NEHhVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjWVFQ4UUN3ME2wMlAzPDJ4IN88US=> MmXOV2FPT0WU
GI-1 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W3U2lEPTB;MD6wNlQ3QSEQvF2= NWnWZoRQW0GQR1XS
LB1047-RCC NXnwNnhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSyRYRtUUN3ME2wMlAzPDh6IN88US=> MVTTRW5ITVJ?
TE-12 M3\DWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG3TWM2OD1yLkCyOVUh|ryP MWHTRW5ITVJ?
MZ7-mel M3LWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvNTWM2OD1yLkCyOlA6KM7:TR?= MoHvV2FPT0WU
MMAC-SF M3PZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n5emlEPTB;MD6wNlY{OyEQvF2= MnjPV2FPT0WU
A101D MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP6TWM2OD1yLkCyOlUh|ryP MYTTRW5ITVJ?
GR-ST NUDVRY9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEK2OVUh|ryP NHvCT5hUSU6JRWK=
MC116 MlzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEK2PEDPxE1? MU\TRW5ITVJ?
Ramos-2G6-4C10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG5TlIzUUN3ME2wMlAzPzVizszN NEnxZ|ZUSU6JRWK=
ATN-1 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjZd4tKSzVyPUCuNFI4QDlizszN NUjs[odXW0GQR1XS
MFH-ino M1HxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSzPJV2UUN3ME2wMlAzQDF{IN88US=> M2Xj[nNCVkeHUh?=
DEL NYK1XYYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXSOXNKSzVyPUCuNFI5OTVizszN M3fMV3NCVkeHUh?=
OCI-AML2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvvNIRrUUN3ME2wMlAzQDdzIN88US=> MXHTRW5ITVJ?
LXF-289 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHwTWM2OD1yLkCyPFczKM7:TR?= M3L4cHNCVkeHUh?=
IA-LM NFnIOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXpTWM2OD1yLkCyPVE4KM7:TR?= NYjCPHBRW0GQR1XS
EoL-1-cell MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEK5PVYh|ryP MoTyV2FPT0WU
OVCAR-4 M1PLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHXXZo5UUN3ME2wMlA{ODl2IN88US=> NFHoclJUSU6JRWK=
ES1 M2nBRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEOwPVch|ryP MoLtV2FPT0WU
CESS NXL1O4g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnwOGJKSzVyPUCuNFMxQTlizszN NUfmV5BrW0GQR1XS
GAK NI\tSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT1TWM2OD1yLkCzNVg3KM7:TR?= Mlm3V2FPT0WU
NTERA-S-cl-D1 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETve4RKSzVyPUCuNFMzOjZizszN NH\pem1USU6JRWK=
TE-10 NYHmTWpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfC[pRvUUN3ME2wMlA{OzFzIN88US=> M2LDWnNCVkeHUh?=
CCRF-CEM NFrLfIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEOzO|Eh|ryP MWfTRW5ITVJ?
NMC-G1 M2frPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvCS4dSUUN3ME2wMlA{PDR6IN88US=> NH35[Y9USU6JRWK=
HOP-62 NFjqSmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\MVIhZUUN3ME2wMlA{PTV4IN88US=> MmPKV2FPT0WU
SH-4 NUDDdFlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEO1PFIh|ryP NHu1SHRUSU6JRWK=
NCI-H1648 MlzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEO2NlIh|ryP NUDJ[lBbW0GQR1XS
EB-3 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PtcGlEPTB;MD6wN|Y1OyEQvF2= MkPiV2FPT0WU
BB65-RCC M3nnVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvPTWM2OD1yLkCzOlkyKM7:TR?= MmTTV2FPT0WU
BE-13 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j5S2lEPTB;MD6wN|c2QSEQvF2= MVvTRW5ITVJ?
CP67-MEL MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMEO3OVkh|ryP NYTrNoZLW0GQR1XS
SW954 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\GTWM2OD1yLkCzO|kh|ryP MVPTRW5ITVJ?
TE-5 NV;HdmNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKwbZVKSzVyPUCuNFM5PTRizszN Ml7WV2FPT0WU
HCE-4 NYO1bmtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7xWppKSzVyPUCuNFM5PTVizszN MnnpV2FPT0WU
LC-1F NWTidlY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTEfW5IUUN3ME2wMlA{QTh7IN88US=> NVTqVnRVW0GQR1XS
TK10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPiTWM2OD1yLkC0NFE6KM7:TR?= MVvTRW5ITVJ?
SJSA-1 NUSxNZFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDLd41KSzVyPUCuNFQyQDhizszN MoLZV2FPT0WU
Daudi MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMESyNlUh|ryP Mle2V2FPT0WU
SW982 NIPsO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ThVGlEPTB;MD6wOFI1PiEQvF2= MWrTRW5ITVJ?
SF126 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TYdGlEPTB;MD6wOFM3OSEQvF2= NY\GdY4{W0GQR1XS
TE-15 MkLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LhXmlEPTB;MD6wOFQ{PSEQvF2= NFewNXFUSU6JRWK=
COLO-684 M{HvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP0NFV4UUN3ME2wMlA1PTZzIN88US=> NIPoWmVUSU6JRWK=
8-MG-BA MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\oTWM2OD1yLkC0OlI6KM7:TR?= M2CxTXNCVkeHUh?=
NB13 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml60TWM2OD1yLkC0O|c3KM7:TR?= M2X6R3NCVkeHUh?=
HCC1599 NFHpV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\Xc|QzUUN3ME2wMlA1QDd7IN88US=> NIGzeJlUSU6JRWK=
SK-PN-DW NIjIOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMES5OFkh|ryP M1TS[3NCVkeHUh?=
ALL-PO NU[4b3FNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMES5OVYh|ryP NIXaZ3NUSU6JRWK=
NB6 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTQTWM2OD1yLkC1NlcyKM7:TR?= M{nhcnNCVkeHUh?=
IST-SL2 M{CyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnPU4tWUUN3ME2wMlA2OzZ{IN88US=> MWTTRW5ITVJ?
BB30-HNC NGDsclZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEW3N{DPxE1? NXvuUoRGW0GQR1XS
SW962 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\DT|hKSzVyPUCuNFU4PjNizszN MVrTRW5ITVJ?
TGBC24TKB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fpW2lEPTB;MD6wOVc6QSEQvF2= NFnRc|FUSU6JRWK=
KINGS-1 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMEW4NFMh|ryP NHLQ[WpUSU6JRWK=
HC-1 NWj2UppLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEW4Nlch|ryP NVPTTYNCW0GQR1XS
RS4-11 NIPZNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILSUoFKSzVyPUCuNFU6OzhizszN NETETohUSU6JRWK=
LS-123 M2D6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jzNGlEPTB;MD6wOVk1OiEQvF2= M1HBO3NCVkeHUh?=
A3-KAW NVnOWpZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFv6OJlKSzVyPUCuNFYzOjVizszN MXvTRW5ITVJ?
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NOMO-1 Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4X2S2lEPTB;MD6zPVk4OSEQvF2= MX;TRW5ITVJ?
MS-1 M2jw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn25TWM2OD1yLkSwNVc4KM7:TR?= NUT0bllvW0GQR1XS
EKVX NHTpTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\RXVZKSzVyPUCuOFQ1PjFizszN MlfjV2FPT0WU
SK-MEL-2 Ml7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwNE[0JO69VQ>? M3jpfnNCVkeHUh?=
HCC1187 NGfHUIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLuTWM2OD1yLkS2O|Y5KM7:TR?= MVLTRW5ITVJ?
HCC2218 NWi2SXNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzWNZRKSzVyPUCuOFczOjdizszN NIjNe3lUSU6JRWK=
NCI-H187 NHzSWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GxXmlEPTB;MD60O|g1KM7:TR?= M37sXXNCVkeHUh?=
DB NH\IUHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwNUCwOVUh|ryP NH2zPI5USU6JRWK=
NCI-H69 NFjxUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXu4d4pYUUN3ME2wMlUxOjR5IN88US=> MkX6V2FPT0WU
NCI-H1694 M1:wbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zVVGlEPTB;MD61NFY6PyEQvF2= M2HGOnNCVkeHUh?=
CA46 NX3NVXdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDETWM2OD1yLkWwPVE4KM7:TR?= NYTNTXYyW0GQR1XS
EHEB M1G1Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDsWI9KUUN3ME2wMlUyOTl|IN88US=> NXfuSlk3W0GQR1XS
NCCIT NGq5e|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwNUSzNlEh|ryP NFXVSXNUSU6JRWK=
NCI-H720 M1;U[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNUS5OlIh|ryP NI\yO4NUSU6JRWK=
LU-134-A MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPwV4dKSzVyPUCuOVUzQTZizszN MXrTRW5ITVJ?
MC-CAR NXf4Z3FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwNUW0N|Eh|ryP M1ntbXNCVkeHUh?=
NEC8 Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PCdGlEPTB;MD61OlE4OiEQvF2= NFm4TYVUSU6JRWK=
NCI-H524 NUT3c3FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXabop{UUN3ME2wMlU5PzR6IN88US=> NV3TU|RrW0GQR1XS
NCI-H1963 NFj2WJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHGxfZdKSzVyPUCuOlI2QCEQvF2= MWLTRW5ITVJ?
SU-DHL-1 NUXhflZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PrR2lEPTB;MD62OFUzPiEQvF2= MmrUV2FPT0WU
NCI-H1522 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfye2NKSzVyPUCuOlQ5QDNizszN NWT5O|dJW0GQR1XS
NCI-H1155 MnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DsT2lEPTB;MD62OVM2KM7:TR?= NXy1O4hIW0GQR1XS
D-263MG NWjKWWdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPndWVKSzVyPUCuOlYyODFizszN MXzTRW5ITVJ?
TE-6 NX3hW2FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Jd41KSzVyPUCuOlgyODRizszN NYTs[ZFoW0GQR1XS
NCI-H1417 M{XS[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHpTWM2OD1yLk[5O|EyKM7:TR?= M3faOHNCVkeHUh?=
NCI-H510A NFfhWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[4TWM2OD1yLke3NlM3KM7:TR?= NXvOepB[W0GQR1XS
KARPAS-45 M1Lhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;uNINKSzVyPUCuO|gzOzVizszN NYrIU4MyW0GQR1XS
IST-SL1 M3XNbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jSO2lEPTB;MD64OVgzPSEQvF2= NVLTfXRRW0GQR1XS
COLO-824 NE[ySZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Owb2lEPTB;MD64O|g{PSEQvF2= MkfpV2FPT0WU
NCI-H526 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Dmb2lEPTB;MD65NFk2QCEQvF2= MVXTRW5ITVJ?
NCI-H719 NUDQO2FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHOOZJPUUN3ME2wMlk3PjV5IN88US=> MV3TRW5ITVJ?
SF539 NHXFcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDPfYpKUUN3ME2wMlk5Ozl4IN88US=> M1i4eHNCVkeHUh?=
NKM-1 M1zlUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwOUi2OlMh|ryP NH;SPXdUSU6JRWK=
A253 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTvWIVpUUN3ME2wMlk5QDh3IN88US=> M{D0SHNCVkeHUh?=
TE-441-T NUjjXlBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjCTnRRUUN3ME2xMlA1OzVizszN NWH0T3RpW0GQR1XS
COR-L88 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwMUGzOVQh|ryP NXPVOXE{W0GQR1XS
CPC-N MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7abIpmUUN3ME2xMlE2QDh6IN88US=> MVPTRW5ITVJ?
NCI-H2107 NXzDU5A{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPWVWdKSzVyPUGuNVczPjFizszN MnfpV2FPT0WU
ECC4 NHW0[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwMUi2PVMh|ryP MnuyV2FPT0WU
NCI-H2141 M37ZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TXOWlEPTB;MT6xPVI6QSEQvF2= NGf1b3lUSU6JRWK=
NCI-H1770 MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fDWWlEPTB;MT6zNlkzQCEQvF2= M3vVU3NCVkeHUh?=
NCI-SNU-1 NFnNdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTMTWM2OD1zLkOzNFQh|ryP MlvNV2FPT0WU
LU-165 M3vRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XUW2lEPTB;MT60OVQ3PyEQvF2= MnrxV2FPT0WU
Raji MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LGfWlEPTB;MT60O|I2QSEQvF2= M{P4NXNCVkeHUh?=
EW-24 MmT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjqTG1UUUN3ME2xMlU1PjF7IN88US=> NUjodFZFW0GQR1XS
KP-N-RT-BM-1 NWewUWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mof2TWM2OD1zLkW2OVUyKM7:TR?= MWHTRW5ITVJ?
SK-MEL-1 NWrHZZpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwNkS4O|ch|ryP NIHPb4hUSU6JRWK=
SCLC-21H NEX1cYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3OeYxyUUN3ME2xMlY3PjVzIN88US=> M3TkdnNCVkeHUh?=
SIMA NGPGXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETa[mxKSzVyPUGuOlgzOzNizszN M2Dp[XNCVkeHUh?=
NCI-H1304 Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwN{C3OlUh|ryP NX3q[4JbW0GQR1XS
REH MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7NTWM2OD1zLkexNFc5KM7:TR?= M3r3SnNCVkeHUh?=
KP-N-YS MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjU[VhsUUN3ME2xMlk{PTVzIN88US=> NUnlR|JWW0GQR1XS
DMS-153 M3jnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\vVGlEPTB;MT65O|U6KM7:TR?= NWe2Um5mW0GQR1XS
NB10 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf3RVd5UUN3ME2yMlIxQDd6IN88US=> NIH2dHZUSU6JRWK=
NCI-H345 NV;ScnJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJwNkG5NFUh|ryP NF7RVY5USU6JRWK=
SK-N-FI NV3rNXRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJwN{WzPFEh|ryP MlqxV2FPT0WU
NCI-H1092 M3;BbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJwOUWzPVQh|ryP MkfxV2FPT0WU
KM-H2 M3PFV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnUTWM2OD1|Lk[1N|k3KM7:TR?= M3frc3NCVkeHUh?=
KG-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3cIVKSzVyPUOuO|E3QDhizszN NW\tToxWW0GQR1XS
D-283MED NHHISpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNwN{W4O{DPxE1? NFvQeYFUSU6JRWK=
LU-65 M1;nW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TaW2lEPTB;ND6xNVQ5PSEQvF2= NYXGcWZpW0GQR1XS
MSTO-211H MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwMUi4PVgh|ryP MlXOV2FPT0WU
NCI-H2081 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG0Zo85UUN3ME20MlI6OTd2IN88US=> MkWzV2FPT0WU
D-247MG M4XGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDESnJNUUN3ME20MlQ{OTlzIN88US=> NVr0bZBwW0GQR1XS
P31-FUJ MknMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jOXWlEPTB;ND60OVAyQSEQvF2= NWXFbYxpW0GQR1XS
DMS-79 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\vd|JKSzVyPUSuPVMyQDNizszN MlnxV2FPT0WU
KASUMI-1 NXWwfnNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPUZmhkUUN3ME20Mlk4PTB7IN88US=> MWLTRW5ITVJ?
JVM-3 NIfBUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknyTWM2OD13LkK1NFE1KM7:TR?= MnnDV2FPT0WU
LAN-6 M4LZbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLjV|BoUUN3ME21MlUyPzN4IN88US=> M2XIcXNCVkeHUh?=
DJM-1 NF\LeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\Ie2lEPTB;NT61OlAzQSEQvF2= M{XYe3NCVkeHUh?=
JVM-2 Mn;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTVwNkewPVIh|ryP MVzTRW5ITVJ?
U-87-MG MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnxcFJSUUN3ME21Mlg6QTZ2IN88US=> M13ZVXNCVkeHUh?=
SHP-77 NVHFWGFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVuxN5J5UUN3ME21Mlk1QTJ6IN88US=> NF7jRldUSU6JRWK=
RPMI-8866 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[xcFZUUUN3ME22MlI4ODF|IN88US=> NIjEOmtUSU6JRWK=
ES7 NH2wS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vqTmlEPTB;Nj6zPVkzPCEQvF2= NFfXTVZUSU6JRWK=
WSU-NHL MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTZwNUG2NFkh|ryP M1LacHNCVkeHUh?=
CAS-1 M4DmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTdwMEm3OFkh|ryP NW\hdYxRW0GQR1XS
MHH-NB-11 M1nqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\LNXZKSzVyPUiuNlMyPTJizszN MU\TRW5ITVJ?
ES5 NYLtb3ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfH[2d[UUN3ME25MlUzOjh4IN88US=> M1vGenNCVkeHUh?=
HDLM-2 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\PTWM2OD17Lkm1PVAzKM7:TR?= MVjTRW5ITVJ?
NCI-H2171 NFfXT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jGUWlEPTB;MUCuOVkzPyEQvF2= Mn\5V2FPT0WU
LNCaP-Clone-FGC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jJWGlEPTB;MUGuN|cyQCEQvF2= NGrMNGxUSU6JRWK=
NCI-H1395 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\xUYs{UUN3ME2xNk4zPjl7IN88US=> NHHRUlVUSU6JRWK=
NCI-H1436 NYK2WXl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jWWGlEPTB;MUOuN|E6PSEQvF2= M2n1T3NCVkeHUh?=
RCC10RGB NGO0RZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPKfoVUUUN3ME2xN{4{OjJzIN88US=> Mmn0V2FPT0WU
SW684 NUfv[4JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETqcmdKSzVyPUGzMlk4QTdizszN NUTRfGE4W0GQR1XS
NCI-H1650 NHPkW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXEblh6UUN3ME2xOU4xPDR5IN88US=> MV;TRW5ITVJ?
EW-13 MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7nOWRKSzVyPUG1MlIxOjFizszN M1zpSHNCVkeHUh?=
EC-GI-10 NInjWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTF3Lki2OFQh|ryP NFvNR5RUSU6JRWK=
CHP-126 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6xXGlKSzVyPUG3MlE6OThizszN MXHTRW5ITVJ?
NCI-H226 NFnJcI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH64T4RKSzVyPUG4MlA1ODNizszN MYTTRW5ITVJ?
NCI-H1838 NHn2fmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\NRppVUUN3ME2yNE4yQDR6IN88US=> NHnoSVJUSU6JRWK=
EW-11 M{\ZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;4cmllUUN3ME2yOE4zPzF6IN88US=> MYXTRW5ITVJ?
EB2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTLVlVMUUN3ME2zNU42OzF6IN88US=> Mm\aV2FPT0WU
D-502MG Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP4TWM2OD12Mz65NlI6KM7:TR?= MWHTRW5ITVJ?
U-698-M NYOzSnlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITKXmhKSzVyPUS4Mlg3PzFizszN M37rUXNCVkeHUh?=
ES3 Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTR7LkO4PVMh|ryP MUjTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID