Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 M2\rfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nMcGlEPTB;MD6wNFA{ODZizszN NFnaNVJUSU6JRWK=
OCUB-M NHLjcoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPPc5hGUUN3ME2wMlAxOTl2IN88US=> NFTpZVlUSU6JRWK=
DOHH-2 NUC1cll1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMECyNlUh|ryP M{PN[HNCVkeHUh?=
NOS-1 MmLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMECyOFIh|ryP NX3EVJU5W0GQR1XS
L-363 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\ybVBHUUN3ME2wMlAxOjh2IN88US=> Ml7KV2FPT0WU
RL95-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMECzNkDPxE1? M13RRXNCVkeHUh?=
BL-70 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DaRWlEPTB;MD6wNFM{PyEQvF2= MmfpV2FPT0WU
TGBC1TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHyzSFFKSzVyPUCuNFA{PzlizszN NWm4cGRRW0GQR1XS
697 M{nvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fWU2lEPTB;MD6wNFY{PCEQvF2= MmnRV2FPT0WU
RPMI-8226 NF;FeHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnjVoJKSzVyPUCuNFA3PTFizszN MkfKV2FPT0WU
BL-41 MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfvTWM2OD1yLkCwOlk3KM7:TR?= M{fDWXNCVkeHUh?=
MRK-nu-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEC3NFch|ryP M{HtWHNCVkeHUh?=
EW-1 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUK1U4lVUUN3ME2wMlAxPzR7IN88US=> MVfTRW5ITVJ?
EVSA-T MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYru[IREUUN3ME2wMlAxQDl{IN88US=> MYTTRW5ITVJ?
HUTU-80 NFfuWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEC5Nlkh|ryP MWHTRW5ITVJ?
VA-ES-BJ MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPBRmhLUUN3ME2wMlAxQTh2IN88US=> MYXTRW5ITVJ?
GCIY Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO4TWM2OD1yLkCxNFA4KM7:TR?= Ml\KV2FPT0WU
ES6 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D3dWlEPTB;MD6wNVA5OyEQvF2= MWrTRW5ITVJ?
NALM-6 Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjRTWM2OD1yLkCxNVAzKM7:TR?= NFnsbWpUSU6JRWK=
LB996-RCC M{G3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K5fWlEPTB;MD6wNVE{PyEQvF2= Mn7PV2FPT0WU
EW-16 MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEGxPVIh|ryP MmfwV2FPT0WU
KALS-1 M{e1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DY[GlEPTB;MD6wNVE6QCEQvF2= NE\VW5lUSU6JRWK=
OPM-2 M4nGWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fWTWlEPTB;MD6wNVI6KM7:TR?= NXzmcW5GW0GQR1XS
KU812 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfvNI5KSzVyPUCuNFEzQTZizszN MWnTRW5ITVJ?
A4-Fuk MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PoZWlEPTB;MD6wNVMyQSEQvF2= NVTBfnZnW0GQR1XS
KGN NITtR5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfuTWM2OD1yLkCxN|U6KM7:TR?= MnrDV2FPT0WU
KS-1 NWG3W4ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPZTWM2OD1yLkCxN|kzKM7:TR?= MlnaV2FPT0WU
no-11 NHjsV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW0TWM2OD1yLkCxN|k2KM7:TR?= MXvTRW5ITVJ?
PSN1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS5TWM2OD1yLkCxOFA6KM7:TR?= MlTHV2FPT0WU
SK-LMS-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUezPXk6UUN3ME2wMlAyPDF|IN88US=> NXLZTWVqW0GQR1XS
LS-411N M{fl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jwV2lEPTB;MD6wNVQ{QSEQvF2= NULUZ5JEW0GQR1XS
HT-144 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEG0OVEh|ryP MXPTRW5ITVJ?
ACN MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4RWxTUUN3ME2wMlAyPSEQvF2= MXTTRW5ITVJ?
RKO M{f6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\LTWM2OD1yLkCxOVM{KM7:TR?= M13JWnNCVkeHUh?=
CMK NXrWfXpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n4b2lEPTB;MD6wNVU1OyEQvF2= MoC4V2FPT0WU
GB-1 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17ENGlEPTB;MD6wNVU2OyEQvF2= NFvTbHJUSU6JRWK=
KE-37 NYPNdWY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMEG1O|Mh|ryP M1\UfnNCVkeHUh?=
no-10 NF7NfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\QTWM2OD1yLkCxOVg1KM7:TR?= NYKzOYxuW0GQR1XS
MOLT-16 NHGwbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzvRXJKSzVyPUCuNFE3OjJizszN NGm4eY5USU6JRWK=
HEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLsVHp6UUN3ME2wMlAyPjRizszN NEOyToRUSU6JRWK=
NCI-H1355 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLSTWM2OD1yLkCxOlQ3KM7:TR?= M2PXPXNCVkeHUh?=
IST-MEL1 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP2TWM2OD1yLkCxO|c1KM7:TR?= NGf3eHdUSU6JRWK=
MHH-PREB-1 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEG4NVgh|ryP MlHkV2FPT0WU
ES8 NV;tN|MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[2eW5KSzVyPUCuNFE5PDRizszN M1PadHNCVkeHUh?=
LC-2-ad NVHpUYVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnFTWM2OD1yLkCyNVM4KM7:TR?= NHr2N4hUSU6JRWK=
LAMA-84 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMEKxOlch|ryP MoPXV2FPT0WU
BV-173 M{jiXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PxSGlEPTB;MD6wNlIxOyEQvF2= MmS2V2FPT0WU
SW872 MonmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq4T4hKSzVyPUCuNFIzPDdizszN MVzTRW5ITVJ?
SK-UT-1 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHCd454UUN3ME2wMlAzOjZzIN88US=> MYHTRW5ITVJ?
OS-RC-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPOTWM2OD1yLkCyN|I{KM7:TR?= NVfLeWNEW0GQR1XS
NCI-H747 Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7hc|JKSzVyPUCuNFI{OyEQvF2= Mk\LV2FPT0WU
MZ2-MEL MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW1XZZuUUN3ME2wMlAzOzN5IN88US=> NV7vfYJyW0GQR1XS
TE-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfIbWl2UUN3ME2wMlAzOzd{IN88US=> MnPzV2FPT0WU
KURAMOCHI Ml7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLwSml[UUN3ME2wMlAzPDF2IN88US=> NHX2R4NUSU6JRWK=
HD-MY-Z M{D3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwMEK0NlYh|ryP NWDMdIhWW0GQR1XS
GI-1 NHi3O|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEK0Olkh|ryP NIf3XmhUSU6JRWK=
LB1047-RCC MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3DWVRrUUN3ME2wMlAzPDh6IN88US=> MX7TRW5ITVJ?
TE-12 NY\zUoh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LpWGlEPTB;MD6wNlU2KM7:TR?= M3K2ZnNCVkeHUh?=
MZ7-mel NVO2NZM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HxU2lEPTB;MD6wNlYxQSEQvF2= NHvZOmNUSU6JRWK=
MMAC-SF M2\sTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml25TWM2OD1yLkCyOlM{KM7:TR?= M{D5WXNCVkeHUh?=
A101D NVn1NXBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCyUXBbUUN3ME2wMlAzPjVizszN MX\TRW5ITVJ?
GR-ST MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f2cWlEPTB;MD6wNlY2PSEQvF2= M1TDZ3NCVkeHUh?=
MC116 M4XJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\BR5VKSzVyPUCuNFI3QCEQvF2= M2P1NnNCVkeHUh?=
Ramos-2G6-4C10 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7YTWM2OD1yLkCyO|Uh|ryP M{LZXnNCVkeHUh?=
ATN-1 NHLCeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYT6XlVNUUN3ME2wMlAzPzh7IN88US=> MkiwV2FPT0WU
MFH-ino MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEK4NVIh|ryP NV7uNYV6W0GQR1XS
DEL NHjRSmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXW1WopEUUN3ME2wMlAzQDF3IN88US=> M3;O[3NCVkeHUh?=
OCI-AML2 NEDqeGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknlTWM2OD1yLkCyPFcyKM7:TR?= MnXvV2FPT0WU
LXF-289 M1Pnc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHU[XJKSzVyPUCuNFI5PzJizszN NXjZc4REW0GQR1XS
IA-LM MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjRTWM2OD1yLkCyPVE4KM7:TR?= Mn\SV2FPT0WU
EoL-1-cell NX;hfIRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Sx[GlEPTB;MD6wNlk6PiEQvF2= NXL0[GZRW0GQR1XS
OVCAR-4 NWPW[GptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\5NpFKSzVyPUCuNFMxQTRizszN MoLYV2FPT0WU
ES1 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj6O5JKSzVyPUCuNFMxQTdizszN NYj6dIJ1W0GQR1XS
CESS NXrzdWZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrZU3dKSzVyPUCuNFMxQTlizszN M33SPHNCVkeHUh?=
GAK M{\1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzCSnRKSzVyPUCuNFMyQDZizszN MVXTRW5ITVJ?
NTERA-S-cl-D1 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\lW|FKSzVyPUCuNFMzOjZizszN NIrZbGhUSU6JRWK=
TE-10 Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LTOWlEPTB;MD6wN|MyOSEQvF2= NVPmcW5xW0GQR1XS
CCRF-CEM NVLVcplwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq3UppKSzVyPUCuNFM{PzFizszN MmjuV2FPT0WU
NMC-G1 MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljJTWM2OD1yLkCzOFQ5KM7:TR?= NHP2bJhUSU6JRWK=
HOP-62 NV7LV5JFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\yVmJqUUN3ME2wMlA{PTV4IN88US=> M4HoNnNCVkeHUh?=
SH-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS3O204UUN3ME2wMlA{PTh{IN88US=> MX;TRW5ITVJ?
NCI-H1648 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy0cIpKSzVyPUCuNFM3OjJizszN NFnYTFlUSU6JRWK=
EB-3 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW0[GJPUUN3ME2wMlA{PjR|IN88US=> NFfpTJhUSU6JRWK=
BB65-RCC M2PMXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDvS2RKSzVyPUCuNFM3QTFizszN M4XvfHNCVkeHUh?=
BE-13 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf5TWM2OD1yLkCzO|U6KM7:TR?= NF21ZZRUSU6JRWK=
CP67-MEL MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEO3OVkh|ryP NEDVZnhUSU6JRWK=
SW954 M1zDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMEO3PUDPxE1? NHuyRWhUSU6JRWK=
TE-5 MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjHTWM2OD1yLkCzPFU1KM7:TR?= NY\1V5FvW0GQR1XS
HCE-4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjTXWdKSzVyPUCuNFM5PTVizszN MoX4V2FPT0WU
LC-1F NWjmXZJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\OTWM2OD1yLkCzPVg6KM7:TR?= M{nT[3NCVkeHUh?=
TK10 NEjaOZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHoTWM2OD1yLkC0NFE6KM7:TR?= M3Oyc3NCVkeHUh?=
SJSA-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzTWM2OD1yLkC0NVg5KM7:TR?= NUnMe3d5W0GQR1XS
Daudi MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInFNItKSzVyPUCuNFQzOjVizszN MknlV2FPT0WU
SW982 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\oTWM2OD1yLkC0NlQ3KM7:TR?= M1\ERnNCVkeHUh?=
SF126 NHrxVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfuTY8yUUN3ME2wMlA1OzZzIN88US=> M1vCSHNCVkeHUh?=
TE-15 NInOO4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMES0N|Uh|ryP MVvTRW5ITVJ?
COLO-684 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGexTVBKSzVyPUCuNFQ2PjFizszN NEnKXnhUSU6JRWK=
8-MG-BA NIH2b|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u5bGlEPTB;MD6wOFYzQSEQvF2= NVHSWplKW0GQR1XS
NB13 M{HCcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jHb2lEPTB;MD6wOFc4PiEQvF2= NFfTPGdUSU6JRWK=
HCC1599 NXPvS|B1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m5T2lEPTB;MD6wOFg4QSEQvF2= Mme4V2FPT0WU
SK-PN-DW NX2xS3pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTrTWM2OD1yLkC0PVQ6KM7:TR?= NGL3T49USU6JRWK=
ALL-PO M2DYZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe5Z3hKSzVyPUCuNFQ6PTZizszN NF7NUoVUSU6JRWK=
NB6 M1v6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzyWWNqUUN3ME2wMlA2OjdzIN88US=> MWXTRW5ITVJ?
IST-SL2 NH\TOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r1SWlEPTB;MD6wOVM3OiEQvF2= M{D3S3NCVkeHUh?=
BB30-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEW3N{DPxE1? NGHrbolUSU6JRWK=
SW962 M2C5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7icFRKSzVyPUCuNFU4PjNizszN M3PKWXNCVkeHUh?=
TGBC24TKB NWPWbW0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjCTWM2OD1yLkC1O|k6KM7:TR?= M13rS3NCVkeHUh?=
KINGS-1 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnWc49KSzVyPUCuNFU5ODNizszN NWS0VldTW0GQR1XS
HC-1 MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rZUWlEPTB;MD6wOVgzPyEQvF2= MoruV2FPT0WU
RS4-11 M33FSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGxVIc2UUN3ME2wMlA2QTN6IN88US=> NHPHUIlUSU6JRWK=
LS-123 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV31eVhjUUN3ME2wMlA2QTR{IN88US=> MnrPV2FPT0WU
A3-KAW NV7rXGlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1q2ZmlEPTB;MD6wOlIzPSEQvF2= MWfTRW5ITVJ?
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SNU-C1 M37GVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwM{iyNVUh|ryP NHLVT25USU6JRWK=
LS-513 M3LDb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVmxcWNxUUN3ME2wMlM6ODdzIN88US=> NFTvbHFUSU6JRWK=
NOMO-1 M{HEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:1RZZKSzVyPUCuN|k6PzFizszN MlPLV2FPT0WU
MS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofXTWM2OD1yLkSwNVc4KM7:TR?= NW\qTpJvW0GQR1XS
EKVX NFHLbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHNTWM2OD1yLkS0OFYyKM7:TR?= MUjTRW5ITVJ?
SK-MEL-2 NWLMNoVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfwTWM2OD1yLkS2OEDPxE1? MXnTRW5ITVJ?
HCC1187 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\SUlVKSzVyPUCuOFY4PjhizszN MmO3V2FPT0WU
HCC2218 NFS4Z2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn6U|VKSzVyPUCuOFczOjdizszN M1GxfnNCVkeHUh?=
NCI-H187 M4O2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwNEe4OEDPxE1? NHq3OldUSU6JRWK=
DB NGr2WIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHzO4I4UUN3ME2wMlUxODV3IN88US=> MYPTRW5ITVJ?
NCI-H69 M3\iTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNUCyOFch|ryP NIrRSW9USU6JRWK=
NCI-H1694 NHXINpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r1dWlEPTB;MD61NFY6PyEQvF2= MULTRW5ITVJ?
CA46 M1Lt[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXvW29iUUN3ME2wMlUxQTF5IN88US=> MoH5V2FPT0WU
EHEB MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TZWGlEPTB;MD61NVE6OyEQvF2= MoPwV2FPT0WU
NCCIT NGjRZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHU[|BMUUN3ME2wMlU1OzJzIN88US=> M3PsZXNCVkeHUh?=
NCI-H720 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DmO2lEPTB;MD61OFk3OiEQvF2= NIP3fFRUSU6JRWK=
LU-134-A MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XaZ2lEPTB;MD61OVI6PiEQvF2= NFi3ZY1USU6JRWK=
MC-CAR NH\lSohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DadWlEPTB;MD61OVQ{OSEQvF2= MX\TRW5ITVJ?
NEC8 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XHVWlEPTB;MD61OlE4OiEQvF2= MYDTRW5ITVJ?
NCI-H524 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi0[ZpKSzVyPUCuOVg4PDhizszN MmXhV2FPT0WU
NCI-H1963 MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7KTWM2OD1yLk[yOVgh|ryP NGn2dVZUSU6JRWK=
SU-DHL-1 NEnBSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7vTG5KSzVyPUCuOlQ2OjZizszN MVXTRW5ITVJ?
NCI-H1522 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\3U2lEPTB;MD62OFg5OyEQvF2= MoTJV2FPT0WU
NCI-H1155 M2rabWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml64TWM2OD1yLk[1N|Uh|ryP M{HSd3NCVkeHUh?=
D-263MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3JTWM2OD1yLk[2NVAyKM7:TR?= NXfEPJRJW0GQR1XS
TE-6 M{TPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHCVoVnUUN3ME2wMlY5OTB2IN88US=> NVzNXnVjW0GQR1XS
NCI-H1417 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInPT4NKSzVyPUCuOlk4OTFizszN Mn\hV2FPT0WU
NCI-H510A M2KyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwN{eyN|Yh|ryP NX\DSHp5W0GQR1XS
KARPAS-45 NGDnS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHkSI9KSzVyPUCuO|gzOzVizszN M4PNbHNCVkeHUh?=
IST-SL1 NUC4Z5l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\hXVJoUUN3ME2wMlg2QDJ3IN88US=> M3zQbXNCVkeHUh?=
COLO-824 NH3GS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTqcFhIUUN3ME2wMlg4QDN3IN88US=> NXPGdmtNW0GQR1XS
NCI-H526 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLKTXpKSzVyPUCuPVA6PThizszN NX3FUG84W0GQR1XS
NCI-H719 M3r5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPJTWM2OD1yLkm2OlU4KM7:TR?= MX\TRW5ITVJ?
SF539 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TwdGlEPTB;MD65PFM6PiEQvF2= MnPiV2FPT0WU
NKM-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOwTZptUUN3ME2wMlk5PjZ|IN88US=> NUGzb4NLW0GQR1XS
A253 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYm5eVdqUUN3ME2wMlk5QDh3IN88US=> MnnSV2FPT0WU
TE-441-T NUXOVmJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3XTWM2OD1zLkC0N|Uh|ryP MoXjV2FPT0WU
COR-L88 NYPSRYxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1njSWlEPTB;MT6xNVM2PCEQvF2= M3TMV3NCVkeHUh?=
CPC-N NXLhPGpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTFwMUW4PFgh|ryP NGntW4lUSU6JRWK=
NCI-H2107 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTKTWM2OD1zLkG3NlYyKM7:TR?= NFnPUmpUSU6JRWK=
ECC4 NU\1RWt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVflfJA1UUN3ME2xMlE5Pjl|IN88US=> NWPHWWxZW0GQR1XS
NCI-H2141 M3u1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTFwMUmyPVkh|ryP MlPTV2FPT0WU
NCI-H1770 M17tb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Cyd2lEPTB;MT6zNlkzQCEQvF2= NUPQb5JXW0GQR1XS
NCI-SNU-1 M4Lk[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3zcFhzUUN3ME2xMlM{ODRizszN MWnTRW5ITVJ?
LU-165 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\USpNKSzVyPUGuOFU1PjdizszN MmniV2FPT0WU
Raji NUCyeldqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXGRZZKSzVyPUGuOFczPTlizszN MnTPV2FPT0WU
EW-24 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;L[YxKSzVyPUGuOVQ3OTlizszN MV;TRW5ITVJ?
KP-N-RT-BM-1 M1LRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vFSmlEPTB;MT61OlU2OSEQvF2= MUPTRW5ITVJ?
SK-MEL-1 M{nlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHIcGNrUUN3ME2xMlY1QDd5IN88US=> MmfrV2FPT0WU
SCLC-21H NUXGb4hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljDTWM2OD1zLk[2OlUyKM7:TR?= MW\TRW5ITVJ?
SIMA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTFwNkiyN|Mh|ryP Mo\pV2FPT0WU
NCI-H1304 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\KTWM2OD1zLkewO|Y2KM7:TR?= MVjTRW5ITVJ?
REH NFv0TWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPvfIRFUUN3ME2xMlcyODd6IN88US=> NVfac5FlW0GQR1XS
KP-N-YS MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTFwOUO1OVEh|ryP NFXJOldUSU6JRWK=
DMS-153 NGH4bmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVezSlBoUUN3ME2xMlk4PTlizszN NWTpeohTW0GQR1XS
NB10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjTbpVkUUN3ME2yMlIxQDd6IN88US=> MlPYV2FPT0WU
NCI-H345 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwNkG5NFUh|ryP NUC4Sm54W0GQR1XS
SK-N-FI NGTr[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TB[2lEPTB;Mj63OVM5OSEQvF2= NIHQZXdUSU6JRWK=
NCI-H1092 NXq3NVVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;jTWM2OD1{Lkm1N|k1KM7:TR?= NXe5U|JuW0GQR1XS
KM-H2 NF6zRZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTNwNkWzPVYh|ryP MlLjV2FPT0WU
KG-1 NEDqUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTNwN{G2PFgh|ryP MnqxV2FPT0WU
D-283MED MlHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljKTWM2OD1|Lke1PFch|ryP M2fTNHNCVkeHUh?=
LU-65 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonQTWM2OD12LkGxOFg2KM7:TR?= MXfTRW5ITVJ?
MSTO-211H NF\S[pFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf2TWF{UUN3ME20MlE5QDl6IN88US=> MYjTRW5ITVJ?
NCI-H2081 NEHtTHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m5fmlEPTB;ND6yPVE4PCEQvF2= NUj1b|lqW0GQR1XS
D-247MG MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XxSWlEPTB;ND60N|E6OSEQvF2= NIHobnZUSU6JRWK=
P31-FUJ MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzPU|d4UUN3ME20MlQ2ODF7IN88US=> NXT4e|BqW0GQR1XS
DMS-79 NX\MWZh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLnTWM2OD12LkmzNVg{KM7:TR?= NXzUR3lCW0GQR1XS
KASUMI-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTRwOUe1NFkh|ryP M3XmdHNCVkeHUh?=
JVM-3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnxTWM2OD13LkK1NFE1KM7:TR?= NGLFZlZUSU6JRWK=
LAN-6 NEnoN|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTVwNUG3N|Yh|ryP NHvtSVlUSU6JRWK=
DJM-1 NE\BT|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW2eIdKSzVyPUWuOVYxOjlizszN MUTTRW5ITVJ?
JVM-2 NGG0bIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rR[mlEPTB;NT62O|A6OiEQvF2= MoS5V2FPT0WU
U-87-MG M4H5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTVwOEm5OlQh|ryP NE\zdYxUSU6JRWK=
SHP-77 M1PYSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPHT2dKSzVyPUWuPVQ6OjhizszN M1\Rd3NCVkeHUh?=
RPMI-8866 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTZwMkewNVMh|ryP M1LBeXNCVkeHUh?=
ES7 MnzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XsWGlEPTB;Nj6zPVkzPCEQvF2= M3qwU3NCVkeHUh?=
WSU-NHL NVTHe5gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu3W2NKUUN3ME22MlUyPjB7IN88US=> M1LzU3NCVkeHUh?=
CAS-1 MoPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWxfYhKSzVyPUeuNFk4PDlizszN M1Pt[XNCVkeHUh?=
MHH-NB-11 MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4noWmlEPTB;OD6yN|E2OiEQvF2= NF60N5dUSU6JRWK=
ES5 NYTNdHBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvWXId6UUN3ME25MlUzOjh4IN88US=> NIraRo9USU6JRWK=
HDLM-2 NFK1ZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fqN2lEPTB;OT65OVkxOiEQvF2= NEnqO49USU6JRWK=
NCI-H2171 NE\UTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\Dd5hoUUN3ME2xNE42QTJ5IN88US=> MXnTRW5ITVJ?
LNCaP-Clone-FGC NE\nUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzV[IVFUUN3ME2xNU4{PzF6IN88US=> MojLV2FPT0WU
NCI-H1395 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfMTWM2OD1zMj6yOlk6KM7:TR?= MlzBV2FPT0WU
NCI-H1436 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLrcplDUUN3ME2xN{4{OTl3IN88US=> NUPMSo9wW0GQR1XS
RCC10RGB NGP2[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfwPZpKSzVyPUGzMlMzOjFizszN MXjTRW5ITVJ?
SW684 MlzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTF|Lkm3PVch|ryP MoPmV2FPT0WU
NCI-H1650 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF3LkC0OFch|ryP NXXwPFM3W0GQR1XS
EW-13 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF3LkKwNlEh|ryP MlH0V2FPT0WU
EC-GI-10 NWPue4pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq3bGVGUUN3ME2xOU45PjR2IN88US=> Mn3QV2FPT0WU
CHP-126 MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nJZWlEPTB;MUeuNVkyQCEQvF2= Mn\uV2FPT0WU
NCI-H226 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nqeWlEPTB;MUiuNFQxOyEQvF2= MVvTRW5ITVJ?
NCI-H1838 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJyLkG4OFgh|ryP M4LYVXNCVkeHUh?=
EW-11 NVHnXnpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJ2LkK3NVgh|ryP MmPIV2FPT0WU
EB2 M1TIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHmTWM2OD1|MT61N|E5KM7:TR?= NITtNW9USU6JRWK=
D-502MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXkTWM2OD12Mz65NlI6KM7:TR?= NXHaW3VnW0GQR1XS
U-698-M MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR6Lki2O|Eh|ryP MlHNV2FPT0WU
ES3 M4XKd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfIPFZvUUN3ME20PU4{QDl|IN88US=> MoL5V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID