Torin 1

Catalog No.S2827

Torin 1 Chemical Structure

Molecular Weight(MW): 607.62

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.

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  • Huh-7.5 cells were treated with increasing concentration of Torin 1, a known autophagy inducer, and the autophagy response was assessed by measuring LC3II and p62 levels.

    Am J Pathol 2014 184(1), 214-29. Torin 1 purchased from Selleck.

    Flag-tagged SENP3 was immunoprecipitated from HeLa cells and used for in vitro phosphorylation assay with [32P]ATP with either the mock-treated or Torin1-treated mTOR/Raptor/MLST8 complex. (Upper) The samples then were subjected to SDS-PAGE, followed by autoradiography. mTOR autophosphorylation is indicated by an asterisk. (Lower) Immunopurified SENP3 was monitored by Western blotting with anti-Flag antibody.

    Mol Cell Biol 2014 34(24), 4474-84. Torin 1 purchased from Selleck.

  • Exp Cell Res, 2018, 363(1):84-94. Torin 1 purchased from Selleck.

    Representative Western blots showing LC3 in PP242 (PP) or Torin1 (Tor) treated HepG2 cells. HepG2 cells were treated with 10 uM PP242 or 0.1 uM Torin1 for 24 h.

    Biochem Biophys Res Commun 2014 10.1016/j.bbrc.2014.05.047. Torin 1 purchased from Selleck.

  • Bone marrow derived macrophages were pre-treated with 10nM Torin 1 for 1h prior to LPS treatment (100 ng/ml). TNF-a production was analyzed 24h later.

    Lim Hsiu Kim, Lina from National University of Singapore. Torin 1 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Targets
mTORC1 [1]
(Cell-free assay)
mTOR [2]
(Cell-free assay)
DNA-PK [2]
(Cell-free assay)
mTORC2 [1]
(Cell-free assay)
p110γ [2]
(Cell-free assay)
2 nM 4.32 nM 6.34 nM 10 nM 171 nM
In vitro

Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases. [1] [2] Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation. [1] In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ETK-1 NGXwe2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXkTWM2OD1yLkCwNFMxPiEQvF2= M1[yNXNCVkeHUh?=
OCUB-M MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\6TWM2OD1yLkCwNVk1KM7:TR?= M4fHcXNCVkeHUh?=
DOHH-2 M4LXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK5UHFKSzVyPUCuNFAzOjVizszN NG\SSVBUSU6JRWK=
NOS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG2O2dKSzVyPUCuNFAzPDJizszN M1v3RXNCVkeHUh?=
L-363 NF:3R5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLEUlRKSzVyPUCuNFAzQDRizszN MXjTRW5ITVJ?
RL95-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMECzNkDPxE1? NGXQdVFUSU6JRWK=
BL-70 M4n0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDUTWM2OD1yLkCwN|M4KM7:TR?= MlHKV2FPT0WU
TGBC1TKB MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP4RotKSzVyPUCuNFA{PzlizszN NYjpc3FYW0GQR1XS
697 NIL0XXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwMEC2N|Qh|ryP M{DnW3NCVkeHUh?=
RPMI-8226 NV;5[ZA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj0TWM2OD1yLkCwOlUyKM7:TR?= MkPkV2FPT0WU
BL-41 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMEC2PVYh|ryP M{fBW3NCVkeHUh?=
MRK-nu-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEC3NFch|ryP NVvQUYdkW0GQR1XS
EW-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj6TWM2OD1yLkCwO|Q6KM7:TR?= NWnYNooxW0GQR1XS
EVSA-T NH\lc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDvTWM2OD1yLkCwPFkzKM7:TR?= Ml3CV2FPT0WU
HUTU-80 M3jvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\YR4FvUUN3ME2wMlAxQTJ7IN88US=> NVyz[XJlW0GQR1XS
VA-ES-BJ NEHzNXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTtWXRsUUN3ME2wMlAxQTh2IN88US=> Moj6V2FPT0WU
GCIY MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvNTWM2OD1yLkCxNFA4KM7:TR?= MmT2V2FPT0WU
ES6 NXrueGZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nBSGlEPTB;MD6wNVA5OyEQvF2= M2LQ[3NCVkeHUh?=
NALM-6 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1iyd2lEPTB;MD6wNVExOiEQvF2= M1rPV3NCVkeHUh?=
LB996-RCC MnrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTuTWM2OD1yLkCxNVM4KM7:TR?= NU\mbXp1W0GQR1XS
EW-16 NIj0[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvkTWM2OD1yLkCxNVkzKM7:TR?= NUPqUXhjW0GQR1XS
KALS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vlfGlEPTB;MD6wNVE6QCEQvF2= MmHIV2FPT0WU
OPM-2 M1vnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELF[pVKSzVyPUCuNFEzQSEQvF2= M1LWXXNCVkeHUh?=
KU812 M3HQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEKxR2VKSzVyPUCuNFEzQTZizszN MnTLV2FPT0WU
A4-Fuk M3KxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLUNZVKSzVyPUCuNFE{OTlizszN NETFVmxUSU6JRWK=
KGN NEnMOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nDdWlEPTB;MD6wNVM2QSEQvF2= NUjyc4hkW0GQR1XS
KS-1 NFXES|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu0TWM2OD1yLkCxN|kzKM7:TR?= NXfqOHdzW0GQR1XS
no-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHm2OnpKSzVyPUCuNFE{QTVizszN M33DenNCVkeHUh?=
PSN1 NHjzNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWCyWoxyUUN3ME2wMlAyPDB7IN88US=> M3vhO3NCVkeHUh?=
SK-LMS-1 MlGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXHZ45pUUN3ME2wMlAyPDF|IN88US=> M{LVNHNCVkeHUh?=
LS-411N MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwMEG0N|kh|ryP NHfJZVNUSU6JRWK=
HT-144 NXKxRZRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXxRo5tUUN3ME2wMlAyPDVzIN88US=> M3f1cnNCVkeHUh?=
ACN NVHyZmZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEG1JO69VQ>? MVPTRW5ITVJ?
RKO MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fyOmlEPTB;MD6wNVU{OyEQvF2= NGHQSVNUSU6JRWK=
CMK NHzBbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEG1OFMh|ryP NHXQfYpUSU6JRWK=
GB-1 NGrn[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DSZmlEPTB;MD6wNVU2OyEQvF2= MWrTRW5ITVJ?
KE-37 M1z2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXJTWM2OD1yLkCxOVc{KM7:TR?= NIrNdm5USU6JRWK=
no-10 NVj6[mxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XGT2lEPTB;MD6wNVU5PCEQvF2= MV7TRW5ITVJ?
MOLT-16 NFz2Z4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEG2NlIh|ryP NYfWVYVtW0GQR1XS
HEL NHL0NplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTzW3RKSzVyPUCuNFE3PCEQvF2= MXvTRW5ITVJ?
NCI-H1355 M4TkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G3fmlEPTB;MD6wNVY1PiEQvF2= M4LLN3NCVkeHUh?=
IST-MEL1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H3WmlEPTB;MD6wNVc4PCEQvF2= M4K3bnNCVkeHUh?=
MHH-PREB-1 M1ewN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEG4NVgh|ryP M3nmN3NCVkeHUh?=
ES8 NGfUOldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\CVWlsUUN3ME2wMlAyQDR2IN88US=> MVLTRW5ITVJ?
LC-2-ad MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL2XpZUUUN3ME2wMlAzOTN5IN88US=> NHm2e|hUSU6JRWK=
LAMA-84 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMEKxOlch|ryP M4H2VnNCVkeHUh?=
BV-173 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHvWlFKSzVyPUCuNFIzODNizszN MVPTRW5ITVJ?
SW872 MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjQN5VKSzVyPUCuNFIzPDdizszN NYXIWGJLW0GQR1XS
SK-UT-1 NV:0SZlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X6b2lEPTB;MD6wNlI3OSEQvF2= M4PRfnNCVkeHUh?=
OS-RC-2 NITTZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTuVZNLUUN3ME2wMlAzOzJ|IN88US=> NYfJW3ptW0GQR1XS
NCI-H747 NUPKTIpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzCS|NKSzVyPUCuNFI{OyEQvF2= MoDoV2FPT0WU
MZ2-MEL M37jUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vIT2lEPTB;MD6wNlM{PyEQvF2= MkXKV2FPT0WU
TE-11 NV7XVHJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrwTFg2UUN3ME2wMlAzOzd{IN88US=> NHnmUllUSU6JRWK=
KURAMOCHI NE\QUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLGTWM2OD1yLkCyOFE1KM7:TR?= MnXtV2FPT0WU
HD-MY-Z NIOxWXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEK0NlYh|ryP M2fQ[XNCVkeHUh?=
GI-1 Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMEK0Olkh|ryP NFLRZ|BUSU6JRWK=
LB1047-RCC NEntdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEK0PFgh|ryP MljjV2FPT0WU
TE-12 M{LwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MniyTWM2OD1yLkCyOVUh|ryP NYDOV3dLW0GQR1XS
MZ7-mel M3e5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEK2NFkh|ryP MWTTRW5ITVJ?
MMAC-SF M{jPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnUZ5d7UUN3ME2wMlAzPjN|IN88US=> MkfXV2FPT0WU
A101D M3fMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX35eINTUUN3ME2wMlAzPjVizszN MV;TRW5ITVJ?
GR-ST MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zQc2lEPTB;MD6wNlY2PSEQvF2= M4jSUnNCVkeHUh?=
MC116 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XZXmlEPTB;MD6wNlY5KM7:TR?= NInVVZZUSU6JRWK=
Ramos-2G6-4C10 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHMNZBMUUN3ME2wMlAzPzVizszN NEXpcZJUSU6JRWK=
ATN-1 MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Kw[mlEPTB;MD6wNlc5QSEQvF2= MUTTRW5ITVJ?
MFH-ino NHu3cY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlntTWM2OD1yLkCyPFEzKM7:TR?= NWKzdI1nW0GQR1XS
DEL MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTSTWM2OD1yLkCyPFE2KM7:TR?= NHzDcIVUSU6JRWK=
OCI-AML2 NGD3PI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjFR5Y{UUN3ME2wMlAzQDdzIN88US=> MoXKV2FPT0WU
LXF-289 NH3DbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\RVJZKSzVyPUCuNFI5PzJizszN NV[2dnE3W0GQR1XS
IA-LM Mkj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyyRo1KSzVyPUCuNFI6OTdizszN M4TaZ3NCVkeHUh?=
EoL-1-cell MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PV[2lEPTB;MD6wNlk6PiEQvF2= M4fLXnNCVkeHUh?=
OVCAR-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LTXWlEPTB;MD6wN|A6PCEQvF2= NVfEUohsW0GQR1XS
ES1 NFj0UYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu4SIhKSzVyPUCuNFMxQTdizszN MWLTRW5ITVJ?
CESS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlezTWM2OD1yLkCzNFk6KM7:TR?= MYfTRW5ITVJ?
GAK MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7pfJAyUUN3ME2wMlA{OTh4IN88US=> MWfTRW5ITVJ?
NTERA-S-cl-D1 M2rjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEOyNlYh|ryP NHjXdGJUSU6JRWK=
TE-10 M2fKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XoOWlEPTB;MD6wN|MyOSEQvF2= MYrTRW5ITVJ?
CCRF-CEM NVXvRZRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\JdmJXUUN3ME2wMlA{OzdzIN88US=> MXjTRW5ITVJ?
NMC-G1 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEO0OFgh|ryP MXTTRW5ITVJ?
HOP-62 M1LZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEO1OVYh|ryP M1jBWnNCVkeHUh?=
SH-4 M4W5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jl[GlEPTB;MD6wN|U5OiEQvF2= NFfESmtUSU6JRWK=
NCI-H1648 M{L4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEO2NlIh|ryP NHfCbWNUSU6JRWK=
EB-3 M2P3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\HfmlEPTB;MD6wN|Y1OyEQvF2= M4n5fHNCVkeHUh?=
BB65-RCC NXvu[VU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfCeZhKSzVyPUCuNFM3QTFizszN MmXBV2FPT0WU
BE-13 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\3U|lKSzVyPUCuNFM4PTlizszN M{GyUXNCVkeHUh?=
CP67-MEL NGr4V3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfkXWlKUUN3ME2wMlA{PzV7IN88US=> MlnZV2FPT0WU
SW954 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITldIpKSzVyPUCuNFM4QSEQvF2= NYTOb|JqW0GQR1XS
TE-5 M4i3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMEO4OVQh|ryP NHz4[GdUSU6JRWK=
HCE-4 NH\RTnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknTTWM2OD1yLkCzPFU2KM7:TR?= NETDT|BUSU6JRWK=
LC-1F MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEi4SoRKSzVyPUCuNFM6QDlizszN Mk\DV2FPT0WU
TK10 NV:0WHdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HjdWlEPTB;MD6wOFAyQSEQvF2= NGXIT5lUSU6JRWK=
SJSA-1 M1rSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvKbWRCUUN3ME2wMlA1OTh6IN88US=> Mk\NV2FPT0WU
Daudi MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTv[HBqUUN3ME2wMlA1OjJ3IN88US=> NUfOfZk{W0GQR1XS
SW982 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvvTWM2OD1yLkC0NlQ3KM7:TR?= MWXTRW5ITVJ?
SF126 MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMESzOlEh|ryP Mk\OV2FPT0WU
TE-15 NXHmdFR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMES0N|Uh|ryP M1HIXHNCVkeHUh?=
COLO-684 NH7pO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXJVXB3UUN3ME2wMlA1PTZzIN88US=> NYDaN|lXW0GQR1XS
8-MG-BA MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMES2Nlkh|ryP MXfTRW5ITVJ?
NB13 NECy[WRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TMWWlEPTB;MD6wOFc4PiEQvF2= NFTlS|lUSU6JRWK=
HCC1599 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknNTWM2OD1yLkC0PFc6KM7:TR?= MUnTRW5ITVJ?
SK-PN-DW M1TFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXhTWM2OD1yLkC0PVQ6KM7:TR?= M2P0OXNCVkeHUh?=
ALL-PO NWjRS217T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPHUXRyUUN3ME2wMlA1QTV4IN88US=> NHezWoJUSU6JRWK=
NB6 NWOxemtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojLTWM2OD1yLkC1NlcyKM7:TR?= NXPRSXJKW0GQR1XS
IST-SL2 M1P4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT4W5FXUUN3ME2wMlA2OzZ{IN88US=> Mn36V2FPT0WU
BB30-HNC NUfrVVdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLNT3BFUUN3ME2wMlA2PzNizszN MkD5V2FPT0WU
SW962 MlP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i5V2lEPTB;MD6wOVc3OyEQvF2= NGDidphUSU6JRWK=
TGBC24TKB NUH4XpN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jRSmlEPTB;MD6wOVc6QSEQvF2= M3:xfXNCVkeHUh?=
KINGS-1 M2jrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPzbIpKSzVyPUCuNFU5ODNizszN MXLTRW5ITVJ?
HC-1 NITs[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHWWlBVUUN3ME2wMlA2QDJ5IN88US=> MlHsV2FPT0WU
RS4-11 NIDRNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu0Nm9KSzVyPUCuNFU6OzhizszN MWjTRW5ITVJ?
LS-123 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXUTWM2OD1yLkC1PVQzKM7:TR?= NGTlWZhUSU6JRWK=
A3-KAW NHLofGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqwTHNKSzVyPUCuNFYzOjVizszN NVGxZocxW0GQR1XS
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LS-513 M1X3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHaZWNUUUN3ME2wMlM6ODdzIN88US=> MVjTRW5ITVJ?
NOMO-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPqPIM4UUN3ME2wMlM6QTdzIN88US=> MmC4V2FPT0WU
MS-1 NHHzS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ZUZhKSzVyPUCuOFAyPzdizszN M3LXXnNCVkeHUh?=
EKVX NWXGXVloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LBPGlEPTB;MD60OFQ3OSEQvF2= NXjmUHB3W0GQR1XS
SK-MEL-2 NVm2dVlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknxTWM2OD1yLkS2OEDPxE1? NWXBd3pNW0GQR1XS
HCC1187 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nvOmlEPTB;MD60Olc3QCEQvF2= MYXTRW5ITVJ?
HCC2218 NVPMRnl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXLdJFKSzVyPUCuOFczOjdizszN MknjV2FPT0WU
NCI-H187 M1L0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\FUJRKSzVyPUCuOFc5PCEQvF2= MWfTRW5ITVJ?
DB MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M12wSGlEPTB;MD61NFA2PSEQvF2= Mnq1V2FPT0WU
NCI-H69 NVvER3VZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPsSVVKSzVyPUCuOVAzPDdizszN NGHTXXhUSU6JRWK=
NCI-H1694 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTyTWM2OD1yLkWwOlk4KM7:TR?= NIrsUVFUSU6JRWK=
CA46 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH6NYpKSzVyPUCuOVA6OTdizszN NYLYXZA{W0GQR1XS
EHEB MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH0N3M4UUN3ME2wMlUyOTl|IN88US=> NInHWo9USU6JRWK=
NCCIT NEHJUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonqTWM2OD1yLkW0N|IyKM7:TR?= MYnTRW5ITVJ?
NCI-H720 NXizUZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwNUS5OlIh|ryP NIHv[XZUSU6JRWK=
LU-134-A MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjEblFkUUN3ME2wMlU2Ojl4IN88US=> M{XxfnNCVkeHUh?=
MC-CAR Mlf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfoZZBSUUN3ME2wMlU2PDNzIN88US=> NV62UWdWW0GQR1XS
NEC8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33CUmlEPTB;MD61OlE4OiEQvF2= NVm4fnlbW0GQR1XS
NCI-H524 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzXfoFKSzVyPUCuOVg4PDhizszN M3nsb3NCVkeHUh?=
NCI-H1963 M1nBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rhXmlEPTB;MD62NlU5KM7:TR?= M3LqeXNCVkeHUh?=
SU-DHL-1 M1HBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7UcYNKSzVyPUCuOlQ2OjZizszN NVjyN49YW0GQR1XS
NCI-H1522 NEPiWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TSe2lEPTB;MD62OFg5OyEQvF2= NXfoR2h{W0GQR1XS
NCI-H1155 NWnW[ZRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHRTWM2OD1yLk[1N|Uh|ryP MlzEV2FPT0WU
D-263MG M2jtPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDo[G1IUUN3ME2wMlY3OTBzIN88US=> NFS5ZVFUSU6JRWK=
TE-6 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwNkixNFQh|ryP NVy2eFJFW0GQR1XS
NCI-H1417 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwNkm3NVEh|ryP NVrBW4hqW0GQR1XS
NCI-H510A NGn6SWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvTdmhrUUN3ME2wMlc4OjN4IN88US=> Mof1V2FPT0WU
KARPAS-45 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv3UHFKSzVyPUCuO|gzOzVizszN NH20em9USU6JRWK=
IST-SL1 NFGzbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjnTWM2OD1yLki1PFI2KM7:TR?= Mn\JV2FPT0WU
COLO-824 NIPPWphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC2fHBKSzVyPUCuPFc5OzVizszN MmjZV2FPT0WU
NCI-H526 MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XZVGlEPTB;MD65NFk2QCEQvF2= M3HKN3NCVkeHUh?=
NCI-H719 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPwTWM2OD1yLkm2OlU4KM7:TR?= M2qyS3NCVkeHUh?=
SF539 NGjOR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHaTWM2OD1yLkm4N|k3KM7:TR?= NXXz[YJPW0GQR1XS
NKM-1 NFrK[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nCeGlEPTB;MD65PFY3OyEQvF2= MV\TRW5ITVJ?
A253 MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm3b3VTUUN3ME2wMlk5QDh3IN88US=> MVfTRW5ITVJ?
TE-441-T NIO0fHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfmXppKSzVyPUGuNFQ{PSEQvF2= Mn\mV2FPT0WU
COR-L88 NYLGNmIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHzb5dzUUN3ME2xMlEyOzV2IN88US=> MYjTRW5ITVJ?
CPC-N NF\nWGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm3TWM2OD1zLkG1PFg5KM7:TR?= MnuyV2FPT0WU
NCI-H2107 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnBW5ZKSzVyPUGuNVczPjFizszN NYrWUIJ7W0GQR1XS
ECC4 NXLudo5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn65TWM2OD1zLkG4Olk{KM7:TR?= M1;jfnNCVkeHUh?=
NCI-H2141 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvrXXFKSzVyPUGuNVkzQTlizszN MnTxV2FPT0WU
NCI-H1770 M32wVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHRXotKSzVyPUGuN|I6OjhizszN MlvXV2FPT0WU
NCI-SNU-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEOwdpFKSzVyPUGuN|MxPCEQvF2= MmjnV2FPT0WU
LU-165 NV7ScmU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGni[nBKSzVyPUGuOFU1PjdizszN NFHKb3FUSU6JRWK=
Raji NXXucoFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fNdGlEPTB;MT60O|I2QSEQvF2= NVu3bXNNW0GQR1XS
EW-24 NXPDNoNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVz2UGZEUUN3ME2xMlU1PjF7IN88US=> M1S4bXNCVkeHUh?=
KP-N-RT-BM-1 NGLyXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPm[5VoUUN3ME2xMlU3PTVzIN88US=> MmTRV2FPT0WU
SK-MEL-1 M4fOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzyTWM2OD1zLk[0PFc4KM7:TR?= NV\PVWNIW0GQR1XS
SCLC-21H NHKwd3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nzTGlEPTB;MT62OlY2OSEQvF2= M4PiW3NCVkeHUh?=
SIMA NUfpTnYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL5SlJjUUN3ME2xMlY5OjN|IN88US=> M4LU[HNCVkeHUh?=
NCI-H1304 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6yTWM2OD1zLkewO|Y2KM7:TR?= NVjG[lVlW0GQR1XS
REH NVLoXY0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXLZVVKSzVyPUGuO|ExPzhizszN MVXTRW5ITVJ?
KP-N-YS MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\pS2lEPTB;MT65N|U2OSEQvF2= MXXTRW5ITVJ?
DMS-153 NGW0WppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXxTWM2OD1zLkm3OVkh|ryP MWTTRW5ITVJ?
NB10 M2fwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJwMkC4O|gh|ryP MWHTRW5ITVJ?
NCI-H345 NUTNfVk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlflTWM2OD1{Lk[xPVA2KM7:TR?= NVW3bXNyW0GQR1XS
SK-N-FI M{PYdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rsO2lEPTB;Mj63OVM5OSEQvF2= NX24bm5[W0GQR1XS
NCI-H1092 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXNTWM2OD1{Lkm1N|k1KM7:TR?= NIq2ZllUSU6JRWK=
KM-H2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULFXIJ{UUN3ME2zMlY2Ozl4IN88US=> M3W2O3NCVkeHUh?=
KG-1 NWnpcYJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX2yT2pGUUN3ME2zMlcyPjh6IN88US=> M3jyWXNCVkeHUh?=
D-283MED NEjTTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTNwN{W4O{DPxE1? MXXTRW5ITVJ?
LU-65 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7aTWM2OD12LkGxOFg2KM7:TR?= MoXzV2FPT0WU
MSTO-211H M2TiNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;kRnpKSzVyPUSuNVg5QThizszN M2KwWnNCVkeHUh?=
NCI-H2081 M4nENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzVV|hDUUN3ME20MlI6OTd2IN88US=> NWGxOWdrW0GQR1XS
D-247MG M{jLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3yfG1[UUN3ME20MlQ{OTlzIN88US=> Mo\0V2FPT0WU
P31-FUJ MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTUdXA{UUN3ME20MlQ2ODF7IN88US=> NFvMcGNUSU6JRWK=
DMS-79 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXUTWM2OD12LkmzNVg{KM7:TR?= M4\jT3NCVkeHUh?=
KASUMI-1 NXXzNlB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonITWM2OD12Lkm3OVA6KM7:TR?= MnP5V2FPT0WU
JVM-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn4[XRKSzVyPUWuNlUxOTRizszN NHX1NVlUSU6JRWK=
LAN-6 M4K0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLnWFc5UUN3ME21MlUyPzN4IN88US=> MXPTRW5ITVJ?
DJM-1 NIrvVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILLbZpKSzVyPUWuOVYxOjlizszN MVLTRW5ITVJ?
JVM-2 NXzNWmMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj3R3dVUUN3ME21MlY4ODl{IN88US=> M{XoWnNCVkeHUh?=
U-87-MG MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTVwOEm5OlQh|ryP M3ztN3NCVkeHUh?=
SHP-77 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTVS4YyUUN3ME21Mlk1QTJ6IN88US=> NIHCbFZUSU6JRWK=
RPMI-8866 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1q1VWlEPTB;Nj6yO|AyOyEQvF2= MVnTRW5ITVJ?
ES7 NYHTW2lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkX3TWM2OD14LkO5PVI1KM7:TR?= NV7vfY0xW0GQR1XS
WSU-NHL M{OzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHuTWM2OD14LkWxOlA6KM7:TR?= NGHPbHhUSU6JRWK=
CAS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLyTWM2OD15LkC5O|Q6KM7:TR?= NHHtNWlUSU6JRWK=
MHH-NB-11 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\ZXWlEPTB;OD6yN|E2OiEQvF2= MlrEV2FPT0WU
ES5 M2HqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTlwNUKyPFYh|ryP MU\TRW5ITVJ?
HDLM-2 NVvqToU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\RTWM2OD17Lkm1PVAzKM7:TR?= NGHUXJdUSU6JRWK=
NCI-H2171 M3voVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\hXml7UUN3ME2xNE42QTJ5IN88US=> MYTTRW5ITVJ?
LNCaP-Clone-FGC NH;sV|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHCbm9KSzVyPUGxMlM4OThizszN NF\tR2VUSU6JRWK=
NCI-H1395 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTF{LkK2PVkh|ryP NHvtXXdUSU6JRWK=
NCI-H1436 NI\jRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfYTWM2OD1zMz6zNVk2KM7:TR?= MWnTRW5ITVJ?
RCC10RGB MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f5d2lEPTB;MUOuN|IzOSEQvF2= M3vQSnNCVkeHUh?=
SW684 MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\uWoxKSzVyPUGzMlk4QTdizszN MmSzV2FPT0WU
NCI-H1650 Ml;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHYXYhKSzVyPUG1MlA1PDdizszN MWrTRW5ITVJ?
EW-13 NFXieYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33qR2lEPTB;MUWuNlAzOSEQvF2= MYnTRW5ITVJ?
EC-GI-10 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF3Lki2OFQh|ryP M1S3U3NCVkeHUh?=
CHP-126 NVOwU4lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rDUWlEPTB;MUeuNVkyQCEQvF2= NVW0PZFNW0GQR1XS
NCI-H226 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTF6LkC0NFMh|ryP MX7TRW5ITVJ?
NCI-H1838 M4nGWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DieWlEPTB;MkCuNVg1QCEQvF2= NEfyfmFUSU6JRWK=
EW-11 NVnEdXFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT6TWM2OD1{ND6yO|E5KM7:TR?= M4\MS3NCVkeHUh?=
EB2 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr4XFRKSzVyPUOxMlU{OThizszN MoXIV2FPT0WU
D-502MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP6RoVIUUN3ME20N{46OjJ7IN88US=> NW\qeHh{W0GQR1XS
U-698-M NGH2XJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfkZ4h{UUN3ME20PE45PjdzIN88US=> NITi[HhUSU6JRWK=
ES3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnOxTWM2OD12OT6zPFk{KM7:TR?= MlzSV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Torin1 is efficacious at a dose of 20 mg/kg in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues. [2]

Protocol

Kinase Assay:[1]
+ Expand

mTORC1 and mTORC2 in Vitro Kinase Assays:

To produce soluble mTORC1, HEK-293T cell lines that stably express N-terminally FLAG-tagged Raptor are generated using vesicular stomatitis virus G-pseudotyped MSCV retrovirus. For mTORC2, similar HeLa cells that stably express N-terminally FLAG-tagged Protor-1 are generated. Both complexes are purified by lysing cells in 50 mm HEPES, pH 7.4, 10 mm sodium pyrophosphate, 10 mm sodium β-glycerophosphate, 100 mm NaCl, 2 mm EDTA, 0.3% CHAPS. Cells are lysed at 4 °C for 30 min, and the insoluble fraction is removed by microcentrifugation at 13,000 rpm for 10 min. Supernatants are incubated with FLAG-M2 monoclonal antibody-agarose for 1 h and then washed three times with lysis buffer and once with lysis buffer containing a final concentration of 0.5 M NaCl. Purified mTORC1 is eluted with 100 μg/mL 3×FLAG peptide in 50 mm HEPES, pH 7.4, 100 mm NaCl. Eluate can be aliquoted and stored at -80 °C. Substrates S6K1 and Akt1 are purified. Kinase assays are performed for 20 min at 30 °C in a final volume of 20 μL consisting of the kinase buffer (25 mm HEPES, pH 7.4, 50 mm KCl, 10 mm MgCl2, 500 μm ATP) and 150 ng of inactive S6K1 or Akt1 as substrates. Reactions are stopped by the addition of 80 μL of sample buffer and boiled for 5 min. Samples are subsequently analyzed by SDS-PAGE and immunoblotting.
Cell Research:[1]
+ Expand
  • Cell lines: MEFs
  • Concentrations: ~250 nM
  • Incubation Time: 4 days
  • Method: Cell viability is assessed with the CellTiter-Glo Luminescent Cell Viability Assay. On Day 0, 96-well plates are seeded with 500 cells per well and grown overnight. On Day 1, cells are treated with the appropriate compounds and subsequently analyzed on Days 3-5. For analysis, plates are incubated for 60 min at room temperature; 50 μL of CellTiter-Glo reagent is added to each well, and plates are mixed on an orbital shaker for 12 min. Luminescence is quantified on a standard plate luminometer.
    (Only for Reference)
Animal Research:[2]
+ Expand
  • Animal Models: U87MG xenograft model
  • Formulation: Torin1 powder is first dissolved at 25 mg/mL in 100% N-methyl-2-pyrrolidone and subsequently diluted 1:4 with sterile 50% PEG400 to a final concentration of 5 mg/mL
  • Dosages: 20 mg/kg
  • Administration: Administered via i.p. once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 2 mg/mL (3.29 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
20% NMP+50% PEG 400
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 607.62
Formula

C35H28F3N5O2

CAS No. 1222998-36-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    How to re-constitute the inhibitor for i.p. administration?

  • Answer:

    S2827 Torin 1 can be dissolved in 5% DMSO/30% PEG 300/ddH2O at 0.25 mg/ml clearly, and in 10% DMSO/corn oil at 0.5 mg/ml, it is also a clear solution.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID