Ponatinib (AP24534)

For research use only.

Catalog No.S1490

98 publications

Ponatinib (AP24534) Chemical Structure

CAS No. 943319-70-8

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.

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Selleck's Ponatinib (AP24534) has been cited by 98 publications

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Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCS2lEPTB;MD6wNFAxODByM{W5JO69VQ>? NFu0[3NUSU6JRWK=
MV-4-11 NITpdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\QTWM2OD1yLkCwNFA6PTZizszN MXPTRW5ITVJ?
MEG-01 M1XpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe2WHRKSzVyPUCuNFAxOTJ6IN88US=> MX3TRW5ITVJ?
LAMA-84 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMECwNVY2KM7:TR?= M37TXnNCVkeHUh?=
CGTH-W-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn2TWM2OD1yLkCwNVY6KM7:TR?= Mo\6V2FPT0WU
KASUMI-1 MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnmNpVKSzVyPUCuNFAzOTdizszN NVq0b2h[W0GQR1XS
BE-13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Pk[2lEPTB;MD6wNFI2QSEQvF2= NGn2NnlUSU6JRWK=
CTV-1 M{jvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEC1NlEh|ryP MXHTRW5ITVJ?
NKM-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHCTWM2OD1yLkCwOlU2KM7:TR?= M334R3NCVkeHUh?=
MONO-MAC-6 NY\peIRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zMOWlEPTB;MD6wNFg{PyEQvF2= NXOyR4lSW0GQR1XS
A204 NH;MU2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO2VFJKSzVyPUCuNFEzOThizszN MU\TRW5ITVJ?
GDM-1 NYD1SpNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXL[mFDUUN3ME2wMlAyQDN|IN88US=> MXHTRW5ITVJ?
AN3-CA MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETPSVVKSzVyPUCuNFE5PzNizszN MX;TRW5ITVJ?
BL-70 NUjJd4xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XQdWlEPTB;MD6wNlE6QSEQvF2= MYrTRW5ITVJ?
Daudi MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEK1N|ch|ryP Mo[wV2FPT0WU
KU812 M1ztPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrUTWM2OD1yLkCyPFQ5KM7:TR?= NXrkNJJVW0GQR1XS
KG-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDTTWM2OD1yLkCzNlk1KM7:TR?= MXXTRW5ITVJ?
DOHH-2 NWPyd|F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL0TWM2OD1yLkC0PFA{KM7:TR?= M1vrRnNCVkeHUh?=
HuO9 NEHPV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEW0OFgh|ryP NULobpFEW0GQR1XS
EB2 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX1TWM2OD1yLkC1OVc3KM7:TR?= M2XGN3NCVkeHUh?=
G-402 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LhbmlEPTB;MD6wOlM1OSEQvF2= MV;TRW5ITVJ?
SU-DHL-1 M4Pwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwME[zO|kh|ryP MofJV2FPT0WU
NCI-H719 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEe4PFgh|ryP M4H5fnNCVkeHUh?=
MLMA MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljSTWM2OD1yLkC5NFYh|ryP NVHmN|l7W0GQR1XS
KM12 NEjWb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGexO2JKSzVyPUCuNFk4OzdizszN NETq[WxUSU6JRWK=
SUP-T1 NHq1SmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrJdmFKSzVyPUCuNFk6QDJizszN Mli5V2FPT0WU
MZ1-PC M3\XN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nNeGlEPTB;MD6xNVM{PiEQvF2= Mn:yV2FPT0WU
MFE-296 NH7uWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXTTWM2OD1yLkGxPFM6KM7:TR?= MXfTRW5ITVJ?
ALL-PO NWjpTHZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq5[m44UUN3ME2wMlEzPDR|IN88US=> NVKySo5bW0GQR1XS
GB-1 NGW3WIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPrOXVKSzVyPUCuNVI2OTJizszN NV3hOXJGW0GQR1XS
SIG-M5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDu[VVKSzVyPUCuNVM{PyEQvF2= NU\zZVFGW0GQR1XS
P30-OHK NYjvW5ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYL6XJh6UUN3ME2wMlE2Pjd{IN88US=> MmnmV2FPT0WU
NCI-H716 M2XOVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMU[yOlYh|ryP M{HUfnNCVkeHUh?=
MPP-89 M3jUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL6fVRnUUN3ME2wMlE3QTN|IN88US=> MUDTRW5ITVJ?
SF126 M{nNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrUdHlIUUN3ME2wMlE4ODZ|IN88US=> MkPEV2FPT0WU
CTB-1 NVH4cm02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknUTWM2OD1yLkG3N|E3KM7:TR?= NHziWHZUSU6JRWK=
CA46 M33tbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMUe0PFkh|ryP NV\hTJVGW0GQR1XS
NCI-H520 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDuVWdqUUN3ME2wMlE4PzN{IN88US=> Ml7FV2FPT0WU
CAL-85-1 NEn0epRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Xu[WlEPTB;MD6xO|kzPyEQvF2= NGXkVHhUSU6JRWK=
NCI-H2342 M4\CO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTqVHFCUUN3ME2wMlE5PTd5IN88US=> MXPTRW5ITVJ?
697 M2Pkdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMUi4O|Eh|ryP NHX3[WdUSU6JRWK=
NY NUTlT2hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HU[WlEPTB;MD6xPVI5PyEQvF2= M4PNdnNCVkeHUh?=
T98G MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTV[m9KSzVyPUCuNVk{OThizszN MUnTRW5ITVJ?
NCI-H1703 NYHLOXl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS2UlV1UUN3ME2wMlE6PjF3IN88US=> MnO4V2FPT0WU
NCI-H2087 NIjZNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36xcWlEPTB;MD6yNFQ{QSEQvF2= MXPTRW5ITVJ?
PF-382 M{X0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn1VWxKSzVyPUCuNlA5PzNizszN M4C0OHNCVkeHUh?=
HCT-116 M2DRc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rNXmlEPTB;MD6yNVA3QSEQvF2= NWGySod5W0GQR1XS
CAKI-1 NEnwZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfMOnl1UUN3ME2wMlIyPjZ4IN88US=> M4DrcnNCVkeHUh?=
CCF-STTG1 M2q3Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMkK0O|Uh|ryP NVPwSJhjW0GQR1XS
D-392MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvSTWM2OD1yLkKzNVc4KM7:TR?= MmrvV2FPT0WU
RT-112 NVnXSVJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlWwTWM2OD1yLkKzO|k2KM7:TR?= MmTUV2FPT0WU
MES-SA MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr0UmpNUUN3ME2wMlI1OTh5IN88US=> NIr1cYJUSU6JRWK=
LC-2-ad MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TiVmlEPTB;MD6yOFI3PSEQvF2= MWnTRW5ITVJ?
NOS-1 NX7YZmN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC5TWM2OD1yLkK0N|Y4KM7:TR?= NGfEXmtUSU6JRWK=
NALM-6 NEPpbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMkW1OFMh|ryP MnnUV2FPT0WU
TE-15 NWT6Nox2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILob3BKSzVyPUCuNlYxQTFizszN MUfTRW5ITVJ?
786-0 M1f0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XOeGlEPTB;MD6yOlIzQCEQvF2= NIWwTlBUSU6JRWK=
IST-MES1 MnPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMk[4Nlkh|ryP MWHTRW5ITVJ?
KYSE-180 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6xTWM2OD1yLkK2PFkyKM7:TR?= MlHLV2FPT0WU
YT MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInwU|BKSzVyPUCuNlY6PzRizszN NVfUb2d3W0GQR1XS
A427 MnnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMkeyOlQh|ryP NE\Fc3lUSU6JRWK=
KYSE-450 NID1VGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMkezNlkh|ryP M2rTcHNCVkeHUh?=
HuH-7 NUj6e5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCxS49CUUN3ME2wMlI4PzZ|IN88US=> NH3jWGtUSU6JRWK=
CAS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\FTWM2OD1yLkK4N|A{KM7:TR?= NWnvblk3W0GQR1XS
KURAMOCHI NIWyTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zsbGlEPTB;MD6yPFQyQSEQvF2= M2OzPHNCVkeHUh?=
ACHN NUnvZXgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILWeW5KSzVyPUCuNlk{OjNizszN MYTTRW5ITVJ?
HGC-27 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMkmzOVMh|ryP NWfQcHVIW0GQR1XS
A172 M3HWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonvTWM2OD1yLkK5OVc4KM7:TR?= NV6x[|cxW0GQR1XS
SNU-449 M3\rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfyTWM2OD1yLkK5PVY1KM7:TR?= M3vhTnNCVkeHUh?=
SW982 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmwOHNYUUN3ME2wMlI6QTd6IN88US=> Mm[yV2FPT0WU
EFO-21 NXzX[XRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwM{C0NVEh|ryP MkDLV2FPT0WU
NCI-H2030 Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwM{GxOlQh|ryP NH\lXHBUSU6JRWK=
HT-144 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK1OItCUUN3ME2wMlMyOjhizszN MkLxV2FPT0WU
MFE-280 NEjWeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r0PGlEPTB;MD6zNVQ2OyEQvF2= MVXTRW5ITVJ?
SK-LU-1 NYnxdXhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{myXWlEPTB;MD6zNVQ3PiEQvF2= M1L3RnNCVkeHUh?=
NCI-H2052 NFn3U4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS2c|lrUUN3ME2wMlMyPDh2IN88US=> M33rWXNCVkeHUh?=
SK-HEP-1 NV\WNm5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXiTWM2OD1yLkOzN|Y5KM7:TR?= MVTTRW5ITVJ?
QIMR-WIL M1PRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwM{O0NlQh|ryP M2PZbnNCVkeHUh?=
A2780 NFu3OVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvBTWM2OD1yLkO0N|A1KM7:TR?= M{CxXHNCVkeHUh?=
ACN MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\td2tKSzVyPUCuN|Q5PzNizszN NFLiPJJUSU6JRWK=
BxPC-3 NWLy[5A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwM{S5PFkh|ryP MV;TRW5ITVJ?
BCPAP MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nOfWlEPTB;MD6zOlAxOSEQvF2= MnjRV2FPT0WU
HOP-62 NGfwUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwM{[xNFYh|ryP NYLhe3czW0GQR1XS
SW1710 M3LCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwM{[0OVUh|ryP M1nuNXNCVkeHUh?=
OPM-2 NXnyUFhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK2TWM2OD1yLkO2OFc{KM7:TR?= MUnTRW5ITVJ?
DBTRG-05MG MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknyTWM2OD1yLkO4NFU1KM7:TR?= NUnYfmx2W0GQR1XS
SK-MEL-24 NW\vPZd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwM{m3PVEh|ryP M1:4OnNCVkeHUh?=
8305C MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwM{m3PVMh|ryP M3uxbXNCVkeHUh?=
OVCAR-4 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLJTWM2OD1yLkSxOVg3KM7:TR?= MorZV2FPT0WU
HLE MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS0[|B3UUN3ME2wMlQyQDZizszN NVH3VWtvW0GQR1XS
NCI-H747 M3XrSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrRTWM2OD1yLkSyNVM4KM7:TR?= NInyUW1USU6JRWK=
SW780 NF;WXpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn2TWM2OD1yLkSyN|Q3KM7:TR?= NXTTV5FsW0GQR1XS
KYSE-150 NHmwbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jVTWlEPTB;MD60NlQyPSEQvF2= MlnwV2FPT0WU
H4 M2m5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3yfmlKSzVyPUCuOFI1PTFizszN NGHUb2lUSU6JRWK=
SW1088 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\3Z4dKSzVyPUCuOFQ{QSEQvF2= NYfw[GdpW0GQR1XS
SF268 NFfkOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvnTWM2OD1yLkS0PFYh|ryP NX[zdIFqW0GQR1XS
RT4 NX65[FFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzkTWM2OD1yLkS1NVEyKM7:TR?= NHj3OXRUSU6JRWK=
NCI-H522 M{PufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPJclNKSzVyPUCuOFUzPyEQvF2= MmXWV2FPT0WU
LCLC-97TM1 M1\rTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jYU2lEPTB;MD60OlE6PSEQvF2= NUS5d2dGW0GQR1XS
CAL-39 NXTN[YN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwNE[1NVkh|ryP MX7TRW5ITVJ?
CAL-120 NUfZS3MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrlTnRmUUN3ME2wMlQ4PjR|IN88US=> MV3TRW5ITVJ?
ESS-1 M{jBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzQUppKSzVyPUCuOFc5OjFizszN Mof0V2FPT0WU
KARPAS-45 Mk\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm4O4tKSzVyPUCuOFg6OzNizszN M2jjT3NCVkeHUh?=
DU-4475 NEHSVoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIriSldKSzVyPUCuOFk2OTFizszN MnPnV2FPT0WU
VMRC-RCZ M3LLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3NUVBKSzVyPUCuOFk6ODRizszN MnH1V2FPT0WU
HOS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnZTWM2OD1yLkWwN|Y2KM7:TR?= M{nuSXNCVkeHUh?=
MOLT-16 M2fTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwNUG4NFgh|ryP M2LNUXNCVkeHUh?=
RPMI-6666 NXLzdIUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojSTWM2OD1yLkWyNVM2KM7:TR?= M3Xq[HNCVkeHUh?=
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L-428 M4LYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;hb4FvUUN3ME2xMlk6OTd7IN88US=> Mn3pV2FPT0WU
KM-H2 NITITpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJwMEGwPUDPxE1? MmfEV2FPT0WU
MC-IXC MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTiepdoUUN3ME2yMlAzOjd|IN88US=> MW\TRW5ITVJ?
COLO-678 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXGxTGRuUUN3ME2yMlA1OjB5IN88US=> M{KyO3NCVkeHUh?=
MEL-JUSO Mk[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDSWY9tUUN3ME2yMlA4QDVzIN88US=> M2jmd3NCVkeHUh?=
HCC38 NG\rRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjVbnpkUUN3ME2yMlA5PDN|IN88US=> M3[2N3NCVkeHUh?=
UACC-62 M3PGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrsTWM2OD1{LkC4PFU2KM7:TR?= NVTBPZM5W0GQR1XS
OAW-42 NHTYeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LtWWlEPTB;Mj6wPVcyOSEQvF2= MnvRV2FPT0WU
LB996-RCC MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrhTWM2OD1{LkGzPFE4KM7:TR?= MXfTRW5ITVJ?
COR-L105 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJwMU[zO|Mh|ryP NI\0W|dUSU6JRWK=
RCC10RGB NGr6bItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVizPGJKUUN3ME2yMlE5PTd4IN88US=> M3S0PHNCVkeHUh?=
A431 M1XId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLVTWM2OD1{LkG5NFE6KM7:TR?= MVvTRW5ITVJ?
NCI-H292 NUSySIdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV74VXljUUN3ME2yMlI{QTVzIN88US=> NEDWUJdUSU6JRWK=
SK-UT-1 NU\ZVXFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\6SZBUUUN3ME2yMlM{OTh2IN88US=> MVfTRW5ITVJ?
PANC-08-13 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoriTWM2OD1{LkOzNlM2KM7:TR?= MYPTRW5ITVJ?
ST486 NHz3U4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrPcZRKSzVyPUKuOFExPDhizszN MWTTRW5ITVJ?
SJSA-1 NWDTWZJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;HTWM2OD1{LkSxNlcyKM7:TR?= NILHflNUSU6JRWK=
RKO NGrFPJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJwNEKwNlkh|ryP M3LZbnNCVkeHUh?=
NCI-H1793 NEO1S2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCwTWM2OD1{LkS0NFI6KM7:TR?= M1zwVnNCVkeHUh?=
639-V MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TIV2lEPTB;Mj60OVM5OiEQvF2= MXXTRW5ITVJ?
ES3 NHvENm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDDRnJPUUN3ME2yMlQ6PzN5IN88US=> MVTTRW5ITVJ?
NCI-H1792 NHHseFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m2dWlEPTB;Mj61OlgzPiEQvF2= NUnkbYE1W0GQR1XS
NCI-H1651 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwNUiyNUDPxE1? MUjTRW5ITVJ?
SN12C NWPpUGdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJwNUi0PFch|ryP NGnhXIFUSU6JRWK=
COLO-679 NHH5TJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjUUFRKSzVyPUKuOVg3ODVizszN MVnTRW5ITVJ?
U-118-MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17DVGlEPTB;Mj61PFg4OiEQvF2= M4XhOHNCVkeHUh?=
Ramos-2G6-4C10 NXT5PVdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJwNkS4NFch|ryP NVnRdpZJW0GQR1XS
HCT-15 NHXSZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLtfFRKSzVyPUKuOlg4QTJizszN NWjG[|BKW0GQR1XS
MDA-MB-157 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGftXnNKSzVyPUKuO|A4PDdizszN NVmyT2dFW0GQR1XS
K5 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTtbm5LUUN3ME2yMlcyQDR3IN88US=> NVHpemVyW0GQR1XS
MKN45 NWjRbXpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjId|hKSzVyPUKuO|M{PjZizszN NELMPW5USU6JRWK=
DMS-273 M4DIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJwN{W2N|Ih|ryP MlOyV2FPT0WU
C8166 NInNdVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvYTWM2OD1{Lke4OVE{KM7:TR?= MnTWV2FPT0WU
Calu-3 NU\tfJpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\VNY5KSzVyPUKuO|g6PjlizszN M3SyOnNCVkeHUh?=
SNB75 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJwOEi1N|Uh|ryP NIfUfItUSU6JRWK=
BFTC-905 NI\QU3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHFTWM2OD1{LkmwNVkyKM7:TR?= MlW5V2FPT0WU
C-4-II MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\BTmlEPTB;Mj65NVM2OyEQvF2= MmXtV2FPT0WU
MS-1 NV[wSXNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT5S5BKSzVyPUKuPVY4PjlizszN Mn\TV2FPT0WU
A375 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrBTWM2OD1|LkC4NVg1KM7:TR?= NXXjWIVCW0GQR1XS
KYSE-70 NW\LU5JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEThPHJKSzVyPUOuNFg5QDJizszN M3SzdnNCVkeHUh?=
KYSE-510 NXvMXmFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT6bIRQUUN3ME2zMlExQTl3IN88US=> NXflXXQ1W0GQR1XS
LN-405 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TiOmlEPTB;Mz6xN|UyQCEQvF2= NFHhUmdUSU6JRWK=
BOKU Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O3TGlEPTB;Mz6xOFI2PiEQvF2= Mln1V2FPT0WU
TE-10 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HmcmlEPTB;Mz6xO|M3OiEQvF2= MVHTRW5ITVJ?
MKN1 NWfYfmlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnDRppKSzVyPUOuNVg1QDNizszN MmTNV2FPT0WU
M059J MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XyXWlEPTB;Mz6yNFE4OyEQvF2= MkK5V2FPT0WU
GOTO NFSzOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTNwMkKwN|kh|ryP MYHTRW5ITVJ?
DK-MG M3LjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPWWoNKSzVyPUOuNlU6PzZizszN NWTIUlNqW0GQR1XS
NCI-H727 NWDWVokzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDzSJFKSzVyPUOuNlY2QCEQvF2= NXjPeHZJW0GQR1XS
NB12 NWDzWXlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn3UlRKSzVyPUOuN|MzOjRizszN NF;6RlNUSU6JRWK=
DOK NWnXW29{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG4O4R2UUN3ME2zMlM3OTh4IN88US=> MUjTRW5ITVJ?
KYSE-410 NFTUXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHPTWM2OD1|LkO2Nlg4KM7:TR?= NHP3dXFUSU6JRWK=
AM-38 M2GzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jVVGlEPTB;Mz6zPFA2OSEQvF2= M1LP[nNCVkeHUh?=
GR-ST MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fWVGlEPTB;Mz60OVc{OiEQvF2= MnTmV2FPT0WU
D-247MG NUP5T|VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTNwNEiyOlMh|ryP MkTEV2FPT0WU
TE-8 NH35SndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvYeYNKSzVyPUOuOFk{OzNizszN MmjlV2FPT0WU
LS-411N MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPiSY1KSzVyPUOuOFk3QTJizszN M{fYTHNCVkeHUh?=
SK-MES-1 NUDubVBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTNwNU[0N|Mh|ryP MYLTRW5ITVJ?
SF295 NF;LPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPhXWlKSzVyPUOuOlE2PTJizszN M{f5VHNCVkeHUh?=
SK-MEL-30 NHv0cldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ztNmlEPTB;Mz62OVkzOSEQvF2= NUPuWoNbW0GQR1XS
LB2241-RCC M{XvNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTLelg4UUN3ME2zMlY3OjZizszN NFfNOW5USU6JRWK=
PC-14 NWHpc2JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj5RW4yUUN3ME2zMlY3PDN5IN88US=> NVrDVnUzW0GQR1XS
EW-7 NHXhPYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXifHJmUUN3ME2zMlY4Pjl|IN88US=> M2LkXXNCVkeHUh?=
NMC-G1 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNwN{G4N|ch|ryP MnjHV2FPT0WU
TE-441-T M{LSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3WWWJXUUN3ME2zMlc{ODJ6IN88US=> NETTNnVUSU6JRWK=
NCI-H1618 NYf0U2htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13jWGlEPTB;Mz64NVg4PSEQvF2= MluyV2FPT0WU
PANC-03-27 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTNwOEG5NVYh|ryP MnHwV2FPT0WU
NCI-H2228 NVHidGJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfrSWpKSzVyPUOuPFMyOjZizszN NV3HcHZoW0GQR1XS
CAPAN-1 M1zsS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPPR5FzUUN3ME2zMlg4ODB7IN88US=> NX;SVmdTW0GQR1XS
KLE NGriSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1npVmlEPTB;Mz65NFY4KM7:TR?= MUTTRW5ITVJ?
Becker NWnMcZo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n2WWlEPTB;Mz65Nlg1QSEQvF2= MmTLV2FPT0WU
SK-PN-DW NIDM[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfITWM2OD12LkC3PVc1KM7:TR?= MlyzV2FPT0WU
Hs-578-T NHj1eWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnOTWM2OD12LkC4N|A3KM7:TR?= NEjQfnNUSU6JRWK=
RS4-11 NX7UfZBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPsfFViUUN3ME20MlEyOjV3IN88US=> NXjYeZA1W0GQR1XS
D-502MG MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW2TWM2OD12LkG2PVk4KM7:TR?= MmHJV2FPT0WU
GI-1 NX\BeoFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTRwMkiyPVkh|ryP NGDlR5RUSU6JRWK=
NCI-H209 MorIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF24VJNKSzVyPUSuN|M4QCEQvF2= MYPTRW5ITVJ?
SK-OV-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq1TWM2OD12LkS4NVQ6KM7:TR?= M2DZVXNCVkeHUh?=
LOUCY Mo[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDkU2FOUUN3ME20MlQ5PDN{IN88US=> M1zjdnNCVkeHUh?=
NCI-H69 M4fySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf5PFhvUUN3ME20MlUyPzl|IN88US=> NYqwfodpW0GQR1XS
SCC-9 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDoNoE1UUN3ME20MlU{OTd{IN88US=> MXLTRW5ITVJ?
NCI-H526 NWDrfGNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTvTmp[UUN3ME20MlU6Ojl|IN88US=> MlnSV2FPT0WU
NCI-H2170 MnjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXqdVlGUUN3ME20MlY3PzdzIN88US=> MXnTRW5ITVJ?
SR M3SzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nteGlEPTB;ND63NFA1QCEQvF2= MUTTRW5ITVJ?
CMK NEnvZnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTRwN{KxNFEh|ryP M4nLdHNCVkeHUh?=
COLO-829 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPVWmxHUUN3ME20Mlc4ODR|IN88US=> NGTvNJdUSU6JRWK=
HuO-3N1 NE\GV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfZSIJrUUN3ME20Mlg{OjhzIN88US=> MV7TRW5ITVJ?
5637 NX\qUmxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTRwOUC0PFch|ryP NFXpc2FUSU6JRWK=
A253 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF20d4NKSzVyPUSuPVc4ODhizszN NHnGU|hUSU6JRWK=
NB10 NYnvPHd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX1[oZKSzVyPUWuNFc1QTdizszN NX\TOVhTW0GQR1XS
SF539 M1\xR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHRfZNKSzVyPUWuNFk6PTlizszN NELKbXdUSU6JRWK=
HAL-01 NIWzSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHrVHpKSzVyPUWuNVQ3PDVizszN MVrTRW5ITVJ?
MHH-ES-1 NXjYOHo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PNUmlEPTB;NT6xOlkzPSEQvF2= NUHobppkW0GQR1XS
DEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTVwMke1PFIh|ryP NHHGW|ZUSU6JRWK=
NCI-H1299 MlrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTVwM{WwNFch|ryP MlPPV2FPT0WU
ChaGo-K-1 NXj6c29KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTVwM{WxNFch|ryP NIHF[odUSU6JRWK=
HMV-II MmjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXRTWM2OD13LkO5OFMh|ryP M1rrdnNCVkeHUh?=
NB69 NFTKd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:xTWM2OD13LkO5OlMyKM7:TR?= NHq5V2hUSU6JRWK=
NCI-H1882 MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTJRo9IUUN3ME21MlQ{OzZ2IN88US=> MlX2V2FPT0WU
SNU-475 NIDaPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfvfnVZUUN3ME21MlQ4OTdzIN88US=> NWrTcZFIW0GQR1XS
RXF393 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HGWmlEPTB;NT60PFQ6PCEQvF2= MoLHV2FPT0WU
CAL-51 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\5UmlEPTB;NT62Nlg2OyEQvF2= M2H0cXNCVkeHUh?=
SW1573 NXXKTWduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTVwNkO1N|Qh|ryP NWXid5NyW0GQR1XS
GCT NXj1NVd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f5NWlEPTB;NT63OVkzQSEQvF2= NHiyU5BUSU6JRWK=
COR-L88 NEHRbHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTJTWM2OD13Lke2PFQ3KM7:TR?= M1\kcXNCVkeHUh?=
MDA-MB-134-VI NYj6TnBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzQTWM2OD13Lki3OVM3KM7:TR?= MWrTRW5ITVJ?
NB5 NYXtfXhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HDSGlEPTB;NT65NlQ1KM7:TR?= NUjvRnFDW0GQR1XS
GMS-10 M1fJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXyXXM{UUN3ME21Mlk3QDZzIN88US=> NVvpbldDW0GQR1XS
CHP-212 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTZwNEiyOlch|ryP NH;ab2hUSU6JRWK=
TE-11 MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnDS3FqUUN3ME22MlU2OTh{IN88US=> NYX5N4ZVW0GQR1XS
SW962 NWq5XWpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y1N2lEPTB;Nj62OVc4PCEQvF2= Ml3DV2FPT0WU
MZ2-MEL MlrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrER5ZHUUN3ME22MlgzODFzIN88US=> NYnsT29rW0GQR1XS
C-33-A MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILIOYdKSzVyPU[uPVE3QDhizszN NHviWlNUSU6JRWK=
IGR-1 M3;ZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\HcGlEPTB;Nj65O|gzPiEQvF2= MljLV2FPT0WU
MOLT-4 M{S5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;4TWM2OD15LkG1OFA3KM7:TR?= NE\uXmFUSU6JRWK=
NCI-H1650 NVruOmN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7MVFNKSzVyPUeuNlcxPDZizszN NFfnTpBUSU6JRWK=
AsPC-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\6UpNkUUN3ME23MlI5PjB3IN88US=> MlTtV2FPT0WU
SNU-C2B NWfjW3RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\jcGlEPTB;Nz6yPVU4OSEQvF2= NGLubYRUSU6JRWK=
MKN7 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Pae2lEPTB;Nz6zO|I{PSEQvF2= NVLOcXk{W0GQR1XS
SW620 NYHXS283T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLoT5VkUUN3ME23MlM5OjB3IN88US=> MkDKV2FPT0WU
SK-MEL-28 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHXe3VCUUN3ME23MlQxPzl6IN88US=> MVTTRW5ITVJ?
TE-6 MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Phc2lEPTB;Nz60OFkxQCEQvF2= M2DFRnNCVkeHUh?=
D-263MG NIn0cIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf3TWM2OD15LkS1O|YzKM7:TR?= M173PXNCVkeHUh?=
NCI-H1355 NHPjSIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTdwN{ewNlkh|ryP MkG0V2FPT0WU
DSH1 MoL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe3bWdKSzVyPUeuO|k4PjJizszN MX;TRW5ITVJ?
NCI-H460 NH\sOVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\lTWM2OD16LkCwOlk1KM7:TR?= NXKzOGJuW0GQR1XS
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NCI-SNU-16 MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP6d4p4UUN3ME25Mlc6PDl3IN88US=> Mk\UV2FPT0WU
NCI-H28 NXvvNokyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnQOlF2UUN3ME25Mlg1QTN|IN88US=> M37pfXNCVkeHUh?=
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NCI-H1993 Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zIV2lEPTB;MUCuOVY6OyEQvF2= M37ORXNCVkeHUh?=
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OAW-28 NHzOO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLsOW42UUN3ME2xNE46QDh6IN88US=> Ml;VV2FPT0WU
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NCI-H1304 NXm5O21JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\LfGlEPTB;MUGuNVU4PiEQvF2= M1j3NHNCVkeHUh?=
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NCI-H2126 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF{LkCyNVgh|ryP M1jTWHNCVkeHUh?=
OVCAR-8 M2WxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF{LkGxOFEh|ryP MnLHV2FPT0WU
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DMS-53 NFPndm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF{LkK2OFkh|ryP NGq3bI1USU6JRWK=
NCI-H322M MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn6TWM2OD1zMj6zN|U4KM7:TR?= NHX1bppUSU6JRWK=
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EFE-184 NF;ydZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF{LkexNFYh|ryP NF\wTZhUSU6JRWK=
BFTC-909 NHzr[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrWb49pUUN3ME2xNk46OjR5IN88US=> NHnGbYhUSU6JRWK=
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EW-3 NVfZPHVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnv[W1MUUN3ME2xN{44OTZ|IN88US=> MoLjV2FPT0WU
HCC1143 MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T5e2lEPTB;MUOuO|Q{PyEQvF2= NXTiOnZmW0GQR1XS
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EFM-19 Mn7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYiyZY9DUUN3ME2xOE4yOTF{IN88US=> NV\Jb486W0GQR1XS
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SKG-IIIa MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TofmlEPTB;MUSuPFg3OiEQvF2= M{jVTnNCVkeHUh?=
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BEN NGGyc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrLTWM2OD1zND65O|Y3KM7:TR?= M1[zNXNCVkeHUh?=
MC116 NXnTT5lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X3fGlEPTB;MUWuNVU6QSEQvF2= NXewO5BmW0GQR1XS
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NCI-H1648 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;DenIyUUN3ME2xOU42OzB3IN88US=> MVrTRW5ITVJ?
ABC-1 M4mxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTF3LkiwN|Mh|ryP MkHGV2FPT0WU
EW-18 NGLNXlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGruenVKSzVyPUG1Mlk6PzlizszN MYnTRW5ITVJ?
BC-3 M1SxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7WSVloUUN3ME2xOk4xPTZ{IN88US=> NGnzOmdUSU6JRWK=
NCI-H1437 M{jpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j1PWlEPTB;MU[uNFY3PyEQvF2= MXPTRW5ITVJ?
SCC-15 NH7wc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF4LkK4NlUh|ryP MVPTRW5ITVJ?
TT Mn\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{C0WGlEPTB;MU[uOVg5QCEQvF2= MVzTRW5ITVJ?
KINGS-1 MoXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HDOWlEPTB;MU[uPFI4OyEQvF2= M4\ySnNCVkeHUh?=
C32 NFy0cVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rrXWlEPTB;MU[uPVcyPyEQvF2= MYnTRW5ITVJ?
SBC-5 NVzBdHVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLRTWM2OD1zNz6xOFc6KM7:TR?= NH\CbZpUSU6JRWK=
NB1 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\ST3ZnUUN3ME2xO{4{OTh6IN88US=> MW\TRW5ITVJ?
EB-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnocHdEUUN3ME2xO{42PzZizszN NILYN|FUSU6JRWK=
NCI-H748 MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPVNW9KSzVyPUG3MlcxOzVizszN Mm\TV2FPT0WU
IST-SL1 M{C3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjWTWM2OD1zNz63OVI3KM7:TR?= M2HyfXNCVkeHUh?=
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NCI-H226 M4jrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTF5Lkm1OFYh|ryP M1vYVnNCVkeHUh?=
CAL-33 M4DXeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHm[FlKSzVyPUG4MlI4QDFizszN Moj4V2FPT0WU
SCC-4 Ml\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu1TWM2OD1zOD6zNlI6KM7:TR?= M4exUHNCVkeHUh?=
RMG-I MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XEO2lEPTB;MUiuOlk1PyEQvF2= NHLGXlRUSU6JRWK=
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A2058 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfFTWM2OD1zOD64NlU2KM7:TR?= MknyV2FPT0WU
HCC70 NIq5NYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HXSGlEPTB;MUmuN|g6PCEQvF2= MUHTRW5ITVJ?
C2BBe1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnSTWM2OD1zOT60NVQ5KM7:TR?= M3XPcHNCVkeHUh?=
NCI-H650 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXaZlF3UUN3ME2xPU42QDl7IN88US=> NUjzNJZDW0GQR1XS
CAL-72 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:2cmlEPTB;MUmuOlc{PyEQvF2= M{TZTnNCVkeHUh?=
L-363 NFnPe|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJyLkCyNVIh|ryP NVvkdpBHW0GQR1XS
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769-P MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJyLk[3Olkh|ryP NGfocHpUSU6JRWK=
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Saos-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrFT2xuUUN3ME2yNE46PTV4IN88US=> NYnESYtnW0GQR1XS
CHP-126 NH;TUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor0TWM2OD1{MT60OFYzKM7:TR?= MWDTRW5ITVJ?
SW837 NIHTUo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;uT|ZMUUN3ME2yNU41QTN7IN88US=> M{L6dnNCVkeHUh?=
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DB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULReIpSUUN3ME2yNU43OTR{IN88US=> NEPsO4tUSU6JRWK=
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COR-L23 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zTWmlEPTB;MkGuPFA2OSEQvF2= NYTFSpZyW0GQR1XS
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T84 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJzLkm4NVkh|ryP M{nofnNCVkeHUh?=
NCI-H630 M33QTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fTZWlEPTB;MkKuOVM3OyEQvF2= MkCwV2FPT0WU
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CAL-62 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjUTWM2OD1{Mj63OVE4KM7:TR?= M3vXdnNCVkeHUh?=
HCE-T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ{Lki2NFYh|ryP NUnHendmW0GQR1XS
BB65-RCC NH\ucHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ|LkCzOFQh|ryP MULTRW5ITVJ?
SiHa MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX1RYdKSzVyPUKzMlM6PjhizszN Mn3OV2FPT0WU
NCI-H2081 MmrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fNcGlEPTB;MkSuNFY1OSEQvF2= MnvRV2FPT0WU
U251 NV;HOopJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJ2LkC2Olgh|ryP NWHEb4VjW0GQR1XS
LoVo MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ2LkmyPFIh|ryP NEfuNoJUSU6JRWK=
GCIY NIn1fXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTrTWM2OD1{NT6yPFc4KM7:TR?= MXvTRW5ITVJ?
NUGC-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\OTWM2OD1{NT6zN|E3KM7:TR?= NHLNZplUSU6JRWK=
LNCaP-Clone-FGC NX\1WIdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3u1R2lEPTB;MkWuN|Q6QCEQvF2= NXW5eYo5W0GQR1XS
PA-1 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2S1T2lEPTB;MkWuOlg{OyEQvF2= NVOxcm1nW0GQR1XS
OE33 M4\6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\RS29KSzVyPUK1MlY5PTNizszN M3rGSHNCVkeHUh?=
HT-29 NIfhVHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu1T3VKSzVyPUK1Mlc5PzlizszN MmDzV2FPT0WU
RCM-1 NHHkbGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DQS2lEPTB;MkWuPVY2PiEQvF2= M4\VT3NCVkeHUh?=
NCI-H1522 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XPUmlEPTB;MkWuPVkyOSEQvF2= MVrTRW5ITVJ?
LB373-MEL-D M1vacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnZbY5vUUN3ME2yOk4yPzB6IN88US=> NIT3cGxUSU6JRWK=
NCI-H1436 M1TpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJ4LkK3N|gh|ryP NWL2N205W0GQR1XS
COLO-824 M3q5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\lTYViUUN3ME2yOk41ODB{IN88US=> Mn\kV2FPT0WU
CP50-MEL-B NFO4c4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoSwTWM2OD1{Nj61Olc2KM7:TR?= NWfLfWxGW0GQR1XS
EGI-1 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJ5LkK2PVgh|ryP MlSyV2FPT0WU
LAN-6 MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jJNGlEPTB;MkeuN|U6QCEQvF2= NIPrUGVUSU6JRWK=
GAK NHXPN5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJ5LkSyNlUh|ryP MUPTRW5ITVJ?
MDA-MB-175-VII NWmzcZJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO0XHhKSzVyPUK3MlUxPTNizszN MkjuV2FPT0WU
JVM-2 Ml:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvxdpU3UUN3ME2yO{43PjJ{IN88US=> NUjjPWZCW0GQR1XS
UACC-257 MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\Re|RCUUN3ME2yO{43QDd6IN88US=> M1\reXNCVkeHUh?=
SW1783 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ5Lke3PFMh|ryP MkPWV2FPT0WU
HT-3 M3XzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P6XGlEPTB;MkiuNlE3PiEQvF2= M4HRO3NCVkeHUh?=
RL NH\SSY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XDOGlEPTB;MkiuOVkyOSEQvF2= NIm3[ZdUSU6JRWK=
TK10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DYcWlEPTB;MkiuOlU{PSEQvF2= M3K3Z3NCVkeHUh?=
HT55 NIXa[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ7LkC1OlUh|ryP NW\oZplrW0GQR1XS
BT-20 NWrIOWpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ7LkC1PFYh|ryP MUXTRW5ITVJ?
TGBC24TKB MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJ7LkG4N|Eh|ryP MmLzV2FPT0WU
HSC-2 NWK5PVFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjwUm9CUUN3ME2yPU4{ODBzIN88US=> M{\IcXNCVkeHUh?=
COLO-205 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjGbpVKSzVyPUK5MlM6PDRizszN NGrqTopUSU6JRWK=
GT3TKB NGrZcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ7Lk[4O|ch|ryP MX7TRW5ITVJ?
T47D MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJ7Lki1PFIh|ryP NYX6XHl4W0GQR1XS
OMC-1 M{nIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HjNmlEPTB;M{CuNVkyQSEQvF2= MYnTRW5ITVJ?
PFSK-1 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvEb5hKSzVyPUOxMlI3PTlizszN MnXBV2FPT0WU
JEG-3 NYHRe2NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\rVpdKSzVyPUOxMlM2PjFizszN MoPUV2FPT0WU
RD MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNzLkWxNVUh|ryP MUHTRW5ITVJ?
NCI-H64 NHvISVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTN{LkSxO|kh|ryP MXPTRW5ITVJ?
DMS-114 NHTnSIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrIPFNKSzVyPUOyMlQyQDJizszN MVjTRW5ITVJ?
NCI-H661 NHvDVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTN{Lk[1NFEh|ryP NXLkbIpVW0GQR1XS
CAL-148 M1P6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjpSItKSzVyPUOyMlY3PjVizszN NEj2fZpUSU6JRWK=
HuP-T3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XWdGlEPTB;M{KuPVM{QCEQvF2= MVzTRW5ITVJ?
ES4 NXLMTpZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HxTGlEPTB;M{OuNVcxPSEQvF2= MYrTRW5ITVJ?
Ca9-22 NUP4UlZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZXol2UUN3ME2zN{41PjBzIN88US=> NIfhXGdUSU6JRWK=
LP-1 MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPpTWM2OD1|ND6wPUDPxE1? MXrTRW5ITVJ?
AU565 NYr1fWxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nFcWlEPTB;M{SuOVA3QSEQvF2= MnjNV2FPT0WU
MDA-MB-453 NHTU[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\xeodKSzVyPUO1MlE1OjZizszN NHPl[lBUSU6JRWK=
SNU-C1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXqTHdVUUN3ME2zOU4yPzFizszN M1L0T3NCVkeHUh?=
SW13 M1rrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTN3LkSwO|Yh|ryP Ml;UV2FPT0WU
NCI-H2122 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjaTWM2OD1|NT61OVk5KM7:TR?= MXzTRW5ITVJ?
NCI-H1395 NHrDOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXwTWM2OD1|NT62OlkyKM7:TR?= MXXTRW5ITVJ?
J-RT3-T3-5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzvTWM2OD1|Nj6wNlk1KM7:TR?= MVLTRW5ITVJ?
COR-L279 Ml\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7NZ|lKSzVyPUO2MlE6QDFizszN NGPjfXFUSU6JRWK=
ATN-1 NWrY[mN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLMcXJQUUN3ME2zOk45PTF4IN88US=> MWHTRW5ITVJ?
HCC2998 NHjrOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;iO5pFUUN3ME2zOk45PTdzIN88US=> MWrTRW5ITVJ?
UM-UC-3 M3S5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS3b5ZKSzVyPUO2Mlg3PzVizszN NGW2R2RUSU6JRWK=
DV-90 M2naOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml20TWM2OD1|Nj65NFY4KM7:TR?= M4TUR3NCVkeHUh?=
ES8 MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHs[YpNUUN3ME2zOk46OzF6IN88US=> MVHTRW5ITVJ?
YAPC M3ryN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjzSWJDUUN3ME2zOk46PjV2IN88US=> NIDhXmpUSU6JRWK=
HCC1599 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnThTWM2OD1|Nz6xOlE5KM7:TR?= NFr2RXdUSU6JRWK=
UMC-11 M4HnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzYTWM2OD1|Nz6yOVA{KM7:TR?= MXHTRW5ITVJ?
THP-1 M{fkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnZVolKSzVyPUO3MlI5PjhizszN MlLLV2FPT0WU
OCUB-M NX73OGxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHEfWJKSzVyPUO3MlI5QTFizszN M4\QO3NCVkeHUh?=
NCI-H1693 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjkTWM2OD1|Nz6zNlM{KM7:TR?= M2rtcXNCVkeHUh?=
NCI-H345 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjBfIV5UUN3ME2zO{4{PjJ2IN88US=> MkTMV2FPT0WU
COLO-800 NHLS[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\lO2lEPTB;M{euOVY4KM7:TR?= NHGzXHBUSU6JRWK=
COLO-320-HSR MkPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W3fGlEPTB;M{iuN|Q6OiEQvF2= NGPPcZJUSU6JRWK=
NCI-H596 MmLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXuTJlKSzVyPUO4MlQ1QDlizszN NFL0TVlUSU6JRWK=
NCI-H187 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTN6LkezOFQh|ryP NEfC[phUSU6JRWK=
ECC4 M1PxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTN7LkC4NVQh|ryP NX2xfpVLW0GQR1XS
KP-4 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M322OmlEPTB;M{muNVI{PSEQvF2= MlzMV2FPT0WU
NCI-H2227 M33iWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\a[WlEPTB;M{muN|k1QSEQvF2= NIjMfmJUSU6JRWK=
22RV1 Mlj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrqRXFKSzVyPUO5Mlg{QThizszN NWLNV2s1W0GQR1XS
SAS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRyLkC5OkDPxE1? MorXV2FPT0WU
PANC-10-05 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXuc2xKSzVyPUSwMlE5OjhizszN NHzjb2VUSU6JRWK=
MDA-MB-468 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjZ[WhKSzVyPUSwMlU{PDZizszN MV7TRW5ITVJ?
RPMI-7951 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTRzLkKwO|Uh|ryP MkPoV2FPT0WU
BB49-HNC M1nIO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTRzLkKxO|kh|ryP NHXHeFRUSU6JRWK=
23132-87 NUPGPWp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTRzLkK3N|Ih|ryP NV7oVlZvW0GQR1XS
HCC1569 NIXDfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzjTWM2OD12MT6yPFg2KM7:TR?= NHrQSJJUSU6JRWK=
CP66-MEL M1vLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3hSoVKSzVyPUSyMlE5QDZizszN NWnUeZExW0GQR1XS
K-562 M3LW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVziVJF2UUN3ME20Nk4zQDV2IN88US=> MnW5V2FPT0WU
OCI-AML2 NIDKU25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn2VnVKSzVyPUSyMlg6PzRizszN NUjiRm1nW0GQR1XS
SW756 M1fBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTR|LkCzPFgh|ryP M3nXRnNCVkeHUh?=
M14 M{H2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHoZYpDUUN3ME20N{4{OTh7IN88US=> MYrTRW5ITVJ?
NCI-H1623 NIHmV3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHuxZ2VKSzVyPUSzMlQ3PCEQvF2= Ml\aV2FPT0WU
KNS-81-FD MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn3TWM2OD12Mz63OlIh|ryP NFm3SWRUSU6JRWK=
TGBC1TKB NEXhO2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q1eGlEPTB;NEOuPVA6QSEQvF2= M2nlVXNCVkeHUh?=
RERF-LC-MS M3r3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR|LkmyPFEh|ryP M2L2e3NCVkeHUh?=
PC-3 M4PoNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXBTWM2OD12ND60N|Q4KM7:TR?= NYXQTINKW0GQR1XS
HuP-T4 M3rRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTR2LkS0O|Qh|ryP Mn;lV2FPT0WU
NCI-H510A MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHxUI1sUUN3ME20OE44ODhizszN NI[5Xm5USU6JRWK=
LB2518-MEL M4Sxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVmxeYZVUUN3ME20OE44QTN5IN88US=> NFrGd4FUSU6JRWK=
TE-5 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy3e2Q2UUN3ME20OU46PThzIN88US=> Mn7GV2FPT0WU
EW-24 NUXJS5hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL6XW9KSzVyPUS2MlE4OjNizszN NYHkcIRDW0GQR1XS
LB647-SCLC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PybmlEPTB;NE[uNlE2PSEQvF2= NVrDTFl5W0GQR1XS
NCI-H524 NF;FcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR4LkexPFUh|ryP M164cHNCVkeHUh?=
EW-11 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHmZY9pUUN3ME20Ok46Ozd|IN88US=> MW\TRW5ITVJ?
KALS-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nkd2lEPTB;NEeuNlA3PiEQvF2= NE\mdo1USU6JRWK=
BT-474 M135WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR5LkSyNVYh|ryP NVH4bGhDW0GQR1XS
SK-N-AS NHvHdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT3TWM2OD12Nz64PFgh|ryP NYXnPXc5W0GQR1XS
HCC2157 M{DkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPEOlJKSzVyPUS4MlA4PiEQvF2= M4nMR3NCVkeHUh?=
HCC1954 M2nQV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT2TWM2OD12OD6xO|A1KM7:TR?= M4ixZXNCVkeHUh?=
FADU M4PuN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HqPWlEPTB;NEiuN|A{OSEQvF2= NVvYfYx5W0GQR1XS
S-117 NXi4[Fh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTR6LkO4NVUh|ryP NX3iO4ZWW0GQR1XS
LS-1034 MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7kelJKSzVyPUS4MlcxPjdizszN M{HVfnNCVkeHUh?=
CAMA-1 NETTOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXUPHRKSzVyPUS5MlU2PDNizszN NX\XTpQyW0GQR1XS
LU-134-A M{nBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\Sd5lpUUN3ME20PU45ODh3IN88US=> MXPTRW5ITVJ?
NCI-H1838 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjpdmRGUUN3ME20PU45ODh5IN88US=> M3zScXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A
Smiles CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04160546 Recruiting Drug: Ponatinib 15 MG|Drug: Acetylsalicylic acid 100 MG Chronic Myeloid Leukemia Chronic Phase Fundacion CRIS de Investigación para Vencer el Cáncer|Incyte Biosciences UK|Apices Soluciones S.L. January 17 2020 Phase 2
NCT04070443 Recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard November 13 2019 Phase 2
NCT03934372 Recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation November 22 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID