Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Cited by 51 Publications

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMECwNFAxODN3OTFOwG0> M1nifnNCVkeHUh?=
MV-4-11 NY\VO3h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECwNFk2PiEQvF2= MmDhV2FPT0WU
MEG-01 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvaU49KSzVyPUCuNFAxOTJ6IN88US=> NHP3VZlUSU6JRWK=
LAMA-84 MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\meWZKSzVyPUCuNFAxOTZ3IN88US=> Mo\uV2FPT0WU
CGTH-W-1 NITuS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLYRVR2UUN3ME2wMlAxOTZ7IN88US=> M1;OfnNCVkeHUh?=
KASUMI-1 NG\LRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWC1WYNuUUN3ME2wMlAxOjF5IN88US=> NELxSW1USU6JRWK=
BE-13 NYLWbZVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[5eWlEPTB;MD6wNFI2QSEQvF2= MmCwV2FPT0WU
CTV-1 M{LHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEC1NlEh|ryP Ml;SV2FPT0WU
NKM-1 NIPMUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\PR29yUUN3ME2wMlAxPjV3IN88US=> NF61XYVUSU6JRWK=
MONO-MAC-6 NYjifGZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:yNJdKSzVyPUCuNFA5OzdizszN M3HRPHNCVkeHUh?=
A204 NFvkZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7OTWM2OD1yLkCxNlE5KM7:TR?= NY\Bb4tXW0GQR1XS
GDM-1 M1q3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f1bGlEPTB;MD6wNVg{OyEQvF2= Mn2wV2FPT0WU
AN3-CA M2HRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PITWlEPTB;MD6wNVg4OyEQvF2= Mor5V2FPT0WU
BL-70 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\RTXNKSzVyPUCuNFIyQTlizszN NYjvfXBpW0GQR1XS
Daudi M4XIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O3c2lEPTB;MD6wNlU{PyEQvF2= NHXTT5lUSU6JRWK=
KU812 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMEK4OFgh|ryP M2PnWXNCVkeHUh?=
KG-1 NX\3[XVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMEOyPVQh|ryP MofiV2FPT0WU
DOHH-2 M13aWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i3U2lEPTB;MD6wOFgxOyEQvF2= NYrSfI1kW0GQR1XS
HuO9 NGHCZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj2TWM2OD1yLkC1OFQ5KM7:TR?= MXvTRW5ITVJ?
EB2 M3rrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[2TWM2OD1yLkC1OVc3KM7:TR?= MVLTRW5ITVJ?
G-402 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\odGlEPTB;MD6wOlM1OSEQvF2= NFHT[4NUSU6JRWK=
SU-DHL-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGyTWM2OD1yLkC2N|c6KM7:TR?= NILzeVRUSU6JRWK=
NCI-H719 NIq3OG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Xp[mlEPTB;MD6wO|g5QCEQvF2= NYTNdJZIW0GQR1XS
MLMA M1PmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEmwOkDPxE1? MYnTRW5ITVJ?
KM12 NY\xNnRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHOTWM2OD1yLkC5O|M4KM7:TR?= NYPXO3p5W0GQR1XS
SUP-T1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn0dYU5UUN3ME2wMlA6QTh{IN88US=> NUfuXmxiW0GQR1XS
MZ1-PC MmjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfLTWM2OD1yLkGxN|M3KM7:TR?= MWnTRW5ITVJ?
MFE-296 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPucoZKSzVyPUCuNVE5OzlizszN NWPUfJlvW0GQR1XS
ALL-PO MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHWR5hKSzVyPUCuNVI1PDNizszN NWfMcow2W0GQR1XS
GB-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDHTIpKSzVyPUCuNVI2OTJizszN NFfRU2RUSU6JRWK=
SIG-M5 M{nCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLud3hiUUN3ME2wMlE{OzdizszN NGrqWWlUSU6JRWK=
P30-OHK NF\te2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLITWM2OD1yLkG1OlczKM7:TR?= NXi3TIpjW0GQR1XS
NCI-H716 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zFOGlEPTB;MD6xOlI3PiEQvF2= Mlq1V2FPT0WU
MPP-89 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnzTWM2OD1yLkG2PVM{KM7:TR?= MkjhV2FPT0WU
SF126 NWHQVVVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fEbGlEPTB;MD6xO|A3OyEQvF2= NWTue|I{W0GQR1XS
CTB-1 NEPC[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj4em1KUUN3ME2wMlE4OzF4IN88US=> MWjTRW5ITVJ?
CA46 NXzrfGI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHBNHJ{UUN3ME2wMlE4PDh7IN88US=> MVLTRW5ITVJ?
NCI-H520 NUHZO|BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDwTWM2OD1yLkG3O|MzKM7:TR?= NEfMNpRUSU6JRWK=
CAL-85-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPtOmtKSzVyPUCuNVc6OjdizszN M{PiOHNCVkeHUh?=
NCI-H2342 M3i5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HnfmlEPTB;MD6xPFU4PyEQvF2= MnO4V2FPT0WU
697 NF[2PGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHiXphKSzVyPUCuNVg5PzFizszN MUHTRW5ITVJ?
NY NWrlN2NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMUmyPFch|ryP MWPTRW5ITVJ?
T98G NVj2Z2ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTxbXhKSzVyPUCuNVk{OThizszN M1nYSnNCVkeHUh?=
NCI-H1703 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojITWM2OD1yLkG5OlE2KM7:TR?= M2PpVXNCVkeHUh?=
NCI-H2087 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMkC0N|kh|ryP Mm\sV2FPT0WU
PF-382 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMkC4O|Mh|ryP M13HW3NCVkeHUh?=
HCT-116 M13vUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nLfGlEPTB;MD6yNVA3QSEQvF2= MUnTRW5ITVJ?
CAKI-1 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH60dotKSzVyPUCuNlE3PjZizszN NXHqOHNPW0GQR1XS
CCF-STTG1 NUfs[IpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIOyd3ZKSzVyPUCuNlI1PzVizszN NFfxOlVUSU6JRWK=
D-392MG NGmwcFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HR[mlEPTB;MD6yN|E4PyEQvF2= NYPqUVF4W0GQR1XS
RT-112 NU\BfJY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f4PGlEPTB;MD6yN|c6PSEQvF2= NXO4NopMW0GQR1XS
MES-SA NULQRpMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDENGZKSzVyPUCuNlQyQDdizszN MVLTRW5ITVJ?
LC-2-ad NEP5XplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z2R2lEPTB;MD6yOFI3PSEQvF2= M3;1NHNCVkeHUh?=
NOS-1 NFu5[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj4TWM2OD1yLkK0N|Y4KM7:TR?= NYeyUZFGW0GQR1XS
NALM-6 MnjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMkW1OFMh|ryP MVPTRW5ITVJ?
TE-15 MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmyTWM2OD1yLkK2NFkyKM7:TR?= NGO3bHdUSU6JRWK=
786-0 NVjBXnAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;HfVZKSzVyPUCuNlYzOjhizszN M3HQb3NCVkeHUh?=
IST-MES1 M3T2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPFTWM2OD1yLkK2PFI6KM7:TR?= MXXTRW5ITVJ?
KYSE-180 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XRXWlEPTB;MD6yOlg6OSEQvF2= NHzZ[Y9USU6JRWK=
YT M{DKUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDqSpJKSzVyPUCuNlY6PzRizszN NWe4[GlmW0GQR1XS
A427 M1fXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PWTGlEPTB;MD6yO|I3PCEQvF2= MlfCV2FPT0WU
KYSE-450 NEjEb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHPSVlKSzVyPUCuNlc{OjlizszN MojsV2FPT0WU
HuH-7 M1j3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:yS2dKSzVyPUCuNlc4PjNizszN MX\TRW5ITVJ?
CAS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTic|AxUUN3ME2wMlI5OzB|IN88US=> M3r4RXNCVkeHUh?=
KURAMOCHI NFvpeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\NOVdKSzVyPUCuNlg1OTlizszN M372NHNCVkeHUh?=
ACHN MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvuOnl{UUN3ME2wMlI6OzJ|IN88US=> MX;TRW5ITVJ?
HGC-27 NVqzfYcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37F[mlEPTB;MD6yPVM2OyEQvF2= NXfPSZdIW0GQR1XS
A172 NF6xVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMkm1O|ch|ryP NFi1[ZhUSU6JRWK=
SNU-449 NXflN|J[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\0XoJKSzVyPUCuNlk6PjRizszN MWXTRW5ITVJ?
SW982 Mnq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XVdGlEPTB;MD6yPVk4QCEQvF2= M1;LenNCVkeHUh?=
EFO-21 MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\DfGw5UUN3ME2wMlMxPDFzIN88US=> NUPh[4pRW0GQR1XS
NCI-H2030 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{D6OGlEPTB;MD6zNVE3PCEQvF2= NWTFR4tWW0GQR1XS
HT-144 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTCTWM2OD1yLkOxNlgh|ryP NHjmfmlUSU6JRWK=
MFE-280 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\BO|JKSzVyPUCuN|E1PTNizszN M3;ZRXNCVkeHUh?=
SK-LU-1 M3zPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vvVGlEPTB;MD6zNVQ3PiEQvF2= M3uyRnNCVkeHUh?=
NCI-H2052 M2LvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fNS2lEPTB;MD6zNVQ5PCEQvF2= NHXBV|FUSU6JRWK=
SK-HEP-1 Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfS[mdkUUN3ME2wMlM{OzZ6IN88US=> MXLTRW5ITVJ?
QIMR-WIL MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vzNGlEPTB;MD6zN|QzPCEQvF2= MVrTRW5ITVJ?
A2780 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1exc2lEPTB;MD6zOFMxPCEQvF2= MYDTRW5ITVJ?
ACN NGrMO5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj1TWM2OD1yLkO0PFc{KM7:TR?= NFvXbZpUSU6JRWK=
BxPC-3 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK3TWM2OD1yLkO0PVg6KM7:TR?= M{HWenNCVkeHUh?=
BCPAP NV\aWHFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TYTWlEPTB;MD6zOlAxOSEQvF2= M4DJUnNCVkeHUh?=
HOP-62 M3TDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoeyTWM2OD1yLkO2NVA3KM7:TR?= Mn\0V2FPT0WU
SW1710 NFHjeGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTIS5RKSzVyPUCuN|Y1PTVizszN MoPWV2FPT0WU
OPM-2 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj6TWM2OD1yLkO2OFc{KM7:TR?= NULqfmluW0GQR1XS
DBTRG-05MG M37VU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnqwTWM2OD1yLkO4NFU1KM7:TR?= NVnxdmp6W0GQR1XS
SK-MEL-24 NV61VHNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwM{m3PVEh|ryP Mn3OV2FPT0WU
8305C MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwM{m3PVMh|ryP M1zUc3NCVkeHUh?=
OVCAR-4 NX\sPJp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjKbWRKSzVyPUCuOFE2QDZizszN MWTTRW5ITVJ?
HLE M3qwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r1bGlEPTB;MD60NVg3KM7:TR?= MYrTRW5ITVJ?
NCI-H747 NW[4eJFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrZTFF1UUN3ME2wMlQzOTN5IN88US=> M1Xw[XNCVkeHUh?=
SW780 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILmdZFKSzVyPUCuOFI{PDZizszN NVvNV5lwW0GQR1XS
KYSE-150 NUnS[mhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCyTWM2OD1yLkSyOFE2KM7:TR?= M4DOPHNCVkeHUh?=
H4 NYXx[HhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LsV2lEPTB;MD60NlQ2OSEQvF2= NF;QOphUSU6JRWK=
SW1088 MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrpTWM2OD1yLkS0N|kh|ryP MXnTRW5ITVJ?
SF268 NGHoOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjGdmxoUUN3ME2wMlQ1QDZizszN NF60T49USU6JRWK=
RT4 NG\2VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPVTWM2OD1yLkS1NVEyKM7:TR?= NEWwbnpUSU6JRWK=
NCI-H522 NF3ZfmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNEWyO{DPxE1? MkDQV2FPT0WU
LCLC-97TM1 NHrUOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwNE[xPVUh|ryP MWHTRW5ITVJ?
CAL-39 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwNE[1NVkh|ryP MmnBV2FPT0WU
CAL-120 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwNEe2OFMh|ryP MUHTRW5ITVJ?
ESS-1 NGTyXWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvETWM2OD1yLkS3PFIyKM7:TR?= MW\TRW5ITVJ?
KARPAS-45 NXfVNnBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PaemlEPTB;MD60PFk{OyEQvF2= NXzyRnJ1W0GQR1XS
DU-4475 NX\zTnh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwNEm1NVEh|ryP M{i5VHNCVkeHUh?=
VMRC-RCZ MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrUTWM2OD1yLkS5PVA1KM7:TR?= MknjV2FPT0WU
HOS MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjITWM2OD1yLkWwN|Y2KM7:TR?= MX3TRW5ITVJ?
MOLT-16 NHXtSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TBeGlEPTB;MD61NVgxQCEQvF2= NF;vdmFUSU6JRWK=
RPMI-6666 NXXKOHBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDQeWxKSzVyPUCuOVIyOzVizszN M1;HenNCVkeHUh?=
K052 NEnKSVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwNUKxOEDPxE1? NFm4NVJUSU6JRWK=
EHEB M4DTZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH2wZ41KSzVyPUCuOVIyQDJizszN MoTtV2FPT0WU
MFH-ino MkfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3pTXk5UUN3ME2wMlUzOzVzIN88US=> NHi1UZVUSU6JRWK=
A4-Fuk NVfSOHZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwNUK1Nlgh|ryP MoXJV2FPT0WU
SW1417 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XF[mlEPTB;MD61Nlc5OSEQvF2= NXjtTHNHW0GQR1XS
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KNS-42 M2PROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPudJE1UUN3ME2xMlg3OjZ4IN88US=> NITMUVRUSU6JRWK=
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KM-H2 Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TEWmlEPTB;Mj6wNVA6KM7:TR?= MnvnV2FPT0WU
MC-IXC NFjEd4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJwMEKyO|Mh|ryP NUP5d4t5W0GQR1XS
COLO-678 M3m4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:yTWM2OD1{LkC0NlA4KM7:TR?= M4fPWnNCVkeHUh?=
MEL-JUSO NYPQUoppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJwMEe4OVEh|ryP NEPvNlRUSU6JRWK=
HCC38 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C0T2lEPTB;Mj6wPFQ{OyEQvF2= NFTaZ5lUSU6JRWK=
UACC-62 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O1TGlEPTB;Mj6wPFg2PSEQvF2= NEjofnpUSU6JRWK=
OAW-42 Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7jc4FKSzVyPUKuNFk4OTFizszN M1\qfXNCVkeHUh?=
LB996-RCC NVXtbo45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HOR2lEPTB;Mj6xN|gyPyEQvF2= NWnSTWpsW0GQR1XS
COR-L105 NWjofpBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W5O2lEPTB;Mj6xOlM4OyEQvF2= M1S0[3NCVkeHUh?=
RCC10RGB M{jzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJwMUi1O|Yh|ryP MX\TRW5ITVJ?
A431 NYnN[3lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vQZWlEPTB;Mj6xPVAyQSEQvF2= MXnTRW5ITVJ?
NCI-H292 NUfscJZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJwMkO5OVEh|ryP M2\IWHNCVkeHUh?=
SK-UT-1 NHK0XphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfDWpBbUUN3ME2yMlM{OTh2IN88US=> MnX6V2FPT0WU
PANC-08-13 NXjVUo9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\1TWM2OD1{LkOzNlM2KM7:TR?= NIfYTVBUSU6JRWK=
ST486 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjxO3pKSzVyPUKuOFExPDhizszN M4\WRnNCVkeHUh?=
SJSA-1 NGHxZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLtcpRKSzVyPUKuOFEzPzFizszN MWnTRW5ITVJ?
RKO MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u0cGlEPTB;Mj60NlAzQSEQvF2= NHXpOWVUSU6JRWK=
NCI-H1793 M1PRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jvR2lEPTB;Mj60OFAzQSEQvF2= MXnTRW5ITVJ?
639-V M4\6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3va[WlEPTB;Mj60OVM5OiEQvF2= NV3weI1IW0GQR1XS
ES3 NXmzUWhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DtRmlEPTB;Mj60PVc{PyEQvF2= NInBNXNUSU6JRWK=
NCI-H1792 NEeycnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTuTWM2OD1{LkW2PFI3KM7:TR?= NGK4[VFUSU6JRWK=
NCI-H1651 M36ySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwNUiyNUDPxE1? M2fz[HNCVkeHUh?=
SN12C Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJwNUi0PFch|ryP NVHObGdrW0GQR1XS
COLO-679 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XMOGlEPTB;Mj61PFYxPSEQvF2= MVvTRW5ITVJ?
U-118-MG NVz5fJBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnr1TWM2OD1{LkW4PFczKM7:TR?= MX7TRW5ITVJ?
Ramos-2G6-4C10 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zOWGlEPTB;Mj62OFgxPyEQvF2= MoDqV2FPT0WU
HCT-15 NX3vWI83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH1TWM2OD1{Lk[4O|kzKM7:TR?= NIjKPXZUSU6JRWK=
MDA-MB-157 NXXFRnM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwN{C3OFch|ryP M370R3NCVkeHUh?=
K5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nkXmlEPTB;Mj63NVg1PSEQvF2= MWjTRW5ITVJ?
MKN45 MoTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXzZXhKSzVyPUKuO|M{PjZizszN NEHicXNUSU6JRWK=
DMS-273 MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjPRoFtUUN3ME2yMlc2PjN{IN88US=> MmLpV2FPT0WU
C8166 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHaUJdKSzVyPUKuO|g2OTNizszN NF\HfplUSU6JRWK=
Calu-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy3b4NXUUN3ME2yMlc5QTZ7IN88US=> NUXX[Yx5W0GQR1XS
SNB75 NFrjNnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDMTWM2OD1{Lki4OVM2KM7:TR?= M13TRXNCVkeHUh?=
BFTC-905 M1nEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzQPHBpUUN3ME2yMlkxOTlzIN88US=> Ml\DV2FPT0WU
C-4-II NGjGZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi1Tmc{UUN3ME2yMlkyOzV|IN88US=> M4P4TnNCVkeHUh?=
MS-1 NFL3SIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XvNGlEPTB;Mj65Olc3QSEQvF2= M1z0THNCVkeHUh?=
A375 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjhOYhGUUN3ME2zMlA5OTh2IN88US=> M{PGb3NCVkeHUh?=
KYSE-70 NHHsbIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPjXWlKSzVyPUOuNFg5QDJizszN MULTRW5ITVJ?
KYSE-510 NX;O[HlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTNwMUC5PVUh|ryP MoD0V2FPT0WU
LN-405 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\GTWM2OD1|LkGzOVE5KM7:TR?= MWDTRW5ITVJ?
BOKU MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jFemlEPTB;Mz6xOFI2PiEQvF2= NXS5OVdyW0GQR1XS
TE-10 NF;ReYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNwMUezOlIh|ryP M37lNHNCVkeHUh?=
MKN1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXG0elJlUUN3ME2zMlE5PDh|IN88US=> MW\TRW5ITVJ?
M059J NYnwOY9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXjfodsUUN3ME2zMlIxOTd|IN88US=> MUHTRW5ITVJ?
GOTO MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTNwMkKwN|kh|ryP M3rGXnNCVkeHUh?=
DK-MG M3fRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7S[pUzUUN3ME2zMlI2QTd4IN88US=> NHjwNm1USU6JRWK=
NCI-H727 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\WTWM2OD1|LkK2OVgh|ryP MWfTRW5ITVJ?
NB12 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHDTWM2OD1|LkOzNlI1KM7:TR?= MnTZV2FPT0WU
DOK Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGntR2lKSzVyPUOuN|YyQDZizszN NWq2VGZWW0GQR1XS
KYSE-410 NHG4[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;aTWM2OD1|LkO2Nlg4KM7:TR?= NH\YR4RUSU6JRWK=
AM-38 M1jOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH5e2ZKSzVyPUOuN|gxPTFizszN M3HhTXNCVkeHUh?=
GR-ST NWLrcWt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DJNGlEPTB;Mz60OVc{OiEQvF2= M{n3RnNCVkeHUh?=
D-247MG M{fvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn76TWM2OD1|LkS4NlY{KM7:TR?= NXTmSGpCW0GQR1XS
TE-8 NGP1OGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37XRWlEPTB;Mz60PVM{OyEQvF2= MX;TRW5ITVJ?
LS-411N MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1uzOmlEPTB;Mz60PVY6OiEQvF2= M3LHUnNCVkeHUh?=
SK-MES-1 M2nUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn4VldKSzVyPUOuOVY1OzNizszN NF\wOnlUSU6JRWK=
SF295 NIDEZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHadZFKSzVyPUOuOlE2PTJizszN MXHTRW5ITVJ?
SK-MEL-30 M{Phdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvVcolKSzVyPUOuOlU6OjFizszN MVzTRW5ITVJ?
LB2241-RCC NXPzN4xGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzTSlVKSzVyPUOuOlYzPiEQvF2= M4DH[HNCVkeHUh?=
PC-14 NFfGb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;ISWlEPTB;Mz62OlQ{PyEQvF2= NVP4e5hlW0GQR1XS
EW-7 NEKz[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXXdHpKSzVyPUOuOlc3QTNizszN NWDMWGZ[W0GQR1XS
NMC-G1 M{TXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnvS4YzUUN3ME2zMlcyQDN5IN88US=> MX3TRW5ITVJ?
TE-441-T NHfj[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoSwTWM2OD1|LkezNFI5KM7:TR?= NGHhO|dUSU6JRWK=
NCI-H1618 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTNwOEG4O|Uh|ryP M2nZO3NCVkeHUh?=
PANC-03-27 NWnlSI42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LOWGlEPTB;Mz64NVkyPiEQvF2= NHfJW3NUSU6JRWK=
NCI-H2228 M1Ph[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL2TWM2OD1|LkizNVI3KM7:TR?= MmPGV2FPT0WU
CAPAN-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rleGlEPTB;Mz64O|AxQSEQvF2= M1;IZ3NCVkeHUh?=
KLE NHHVPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTNwOUC2O{DPxE1? M1H6TnNCVkeHUh?=
Becker M2r4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTNwOUK4OFkh|ryP MXPTRW5ITVJ?
SK-PN-DW M1PHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTyTWM2OD12LkC3PVc1KM7:TR?= MV3TRW5ITVJ?
Hs-578-T Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36wRWlEPTB;ND6wPFMxPiEQvF2= NWKxfpZMW0GQR1XS
RS4-11 NUDhfHkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKxTWM2OD12LkGxNlU2KM7:TR?= NYfDOppjW0GQR1XS
D-502MG NFizUFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXntfJFJUUN3ME20MlE3QTl5IN88US=> M2e3dXNCVkeHUh?=
GI-1 NWO5R4t5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfjdodLUUN3ME20MlI5Ojl7IN88US=> NHO2SFZUSU6JRWK=
NCI-H209 M1qzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;2TWM2OD12LkOzO|gh|ryP Ml;MV2FPT0WU
SK-OV-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;rUGlEPTB;ND60PFE1QSEQvF2= NYfIOo5mW0GQR1XS
LOUCY M2LRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfSPJpKSzVyPUSuOFg1OzJizszN M125dHNCVkeHUh?=
NCI-H69 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnIRnZsUUN3ME20MlUyPzl|IN88US=> NIm5bZZUSU6JRWK=
SCC-9 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDQWG13UUN3ME20MlU{OTd{IN88US=> MYTTRW5ITVJ?
NCI-H526 Ml;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy5R2F1UUN3ME20MlU6Ojl|IN88US=> MmX3V2FPT0WU
NCI-H2170 MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP4U|BKSzVyPUSuOlY4PzFizszN MUfTRW5ITVJ?
SR Ml;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\mSlhTUUN3ME20MlcxODR6IN88US=> MYPTRW5ITVJ?
CMK NX;RdWJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS1TWM2OD12LkeyNVAyKM7:TR?= NUTmVoh{W0GQR1XS
COLO-829 M1vuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz6TWM2OD12Lke3NFQ{KM7:TR?= MoTvV2FPT0WU
HuO-3N1 NVuyOmg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKyZmtKSzVyPUSuPFMzQDFizszN NYnwNnM3W0GQR1XS
5637 NGfIR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1u5VmlEPTB;ND65NFQ5PyEQvF2= M1fPTXNCVkeHUh?=
A253 NVOyfohCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[2VmlEPTB;ND65O|cxQCEQvF2= M4ezenNCVkeHUh?=
NB10 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPqTWM2OD13LkC3OFk4KM7:TR?= MkC2V2FPT0WU
SF539 Mn3FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPzdW5ZUUN3ME21MlA6QTV7IN88US=> Mk\OV2FPT0WU
HAL-01 M4TLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTRTWM2OD13LkG0OlQ2KM7:TR?= MVnTRW5ITVJ?
MHH-ES-1 NGLmbY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW2RpNKSzVyPUWuNVY6OjVizszN NVOwXVJRW0GQR1XS
DEL NVux[5YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnCV4hKSzVyPUWuNlc2QDJizszN Mk\GV2FPT0WU
NCI-H1299 M{\iPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\aZ41uUUN3ME21MlM2ODB5IN88US=> MUjTRW5ITVJ?
ChaGo-K-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\CR2duUUN3ME21MlM2OTB5IN88US=> NGnxb3JUSU6JRWK=
HMV-II NF;MToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi3fpRUUUN3ME21MlM6PDNizszN NUfm[FBGW0GQR1XS
NB69 M2LjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfhfIRNUUN3ME21MlM6PjNzIN88US=> NVTScm5qW0GQR1XS
NCI-H1882 M2H1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHlTWM2OD13LkSzN|Y1KM7:TR?= MU\TRW5ITVJ?
SNU-475 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDHNI5KSzVyPUWuOFcyPzFizszN M17kZ3NCVkeHUh?=
RXF393 NX3Tfm5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTVwNEi0PVQh|ryP NVLMUI1QW0GQR1XS
CAL-51 M4\PPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\5U|ZKSzVyPUWuOlI5PTNizszN MXHTRW5ITVJ?
SW1573 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NICzRXhKSzVyPUWuOlM2OzRizszN NEW1T3lUSU6JRWK=
GCT M1ntU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nONmlEPTB;NT63OVkzQSEQvF2= NIHwUWVUSU6JRWK=
COR-L88 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTVwN{[4OFYh|ryP MnzwV2FPT0WU
MDA-MB-134-VI Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTVwOEe1N|Yh|ryP MWLTRW5ITVJ?
NB5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGw[5hKSzVyPUWuPVI1PCEQvF2= Mme2V2FPT0WU
GMS-10 NHfHe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvhTWM2OD13Lkm2PFYyKM7:TR?= M1zmTXNCVkeHUh?=
CHP-212 MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6xfY5KSzVyPU[uOFgzPjdizszN NVrP[FBCW0GQR1XS
TE-11 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnMTXhKSzVyPU[uOVUyQDJizszN MmGxV2FPT0WU
SW962 NXflN5NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;Je2lEPTB;Nj62OVc4PCEQvF2= NVz2WlVGW0GQR1XS
MZ2-MEL MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH25TGVKSzVyPU[uPFIxOTFizszN NULYWFlJW0GQR1XS
C-33-A NV3iWXJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17lbmlEPTB;Nj65NVY5QCEQvF2= NV;aVoRNW0GQR1XS
IGR-1 Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fz[GlEPTB;Nj65O|gzPiEQvF2= M2XaTnNCVkeHUh?=
MOLT-4 MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX0fGtKSzVyPUeuNVU1ODZizszN MmLUV2FPT0WU
NCI-H1650 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zEemlEPTB;Nz6yO|A1PiEQvF2= MmLTV2FPT0WU
AsPC-1 NV;I[3NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\oVoliUUN3ME23MlI5PjB3IN88US=> NEHXblBUSU6JRWK=
SNU-C2B MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nleGlEPTB;Nz6yPVU4OSEQvF2= NHLp[lJUSU6JRWK=
MKN7 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK0TWM2OD15LkO3NlM2KM7:TR?= NH\keWhUSU6JRWK=
SW620 NWrD[lBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7SbFBKSzVyPUeuN|gzODVizszN MXrTRW5ITVJ?
SK-MEL-28 NIfZPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfVTWM2OD15LkSwO|k5KM7:TR?= NGnlUmdUSU6JRWK=
TE-6 M{HCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrMZWExUUN3ME23MlQ1QTB6IN88US=> NYDWR5FGW0GQR1XS
D-263MG M{nxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rhRmlEPTB;Nz60OVc3OiEQvF2= NEmweppUSU6JRWK=
NCI-H1355 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jiXWlEPTB;Nz63O|AzQSEQvF2= MVTTRW5ITVJ?
DSH1 MoDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzzNHdUUUN3ME23Mlc6PzZ{IN88US=> M4C4XXNCVkeHUh?=
NCI-H460 NEWwPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRThwMEC2PVQh|ryP Mn7NV2FPT0WU
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NCI-H2081 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf3XotKSzVyPUK0MlA3PDFizszN NV7SR2FRW0GQR1XS
U251 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLnTWM2OD1{ND6wOlY5KM7:TR?= NWXVdo1mW0GQR1XS
LoVo NXrRVVk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDQTWM2OD1{ND65NlgzKM7:TR?= MlrHV2FPT0WU
GCIY NIn6RWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH2fodKSzVyPUK1MlI5PzdizszN MVTTRW5ITVJ?
NUGC-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ3LkOzNVYh|ryP M2GzWnNCVkeHUh?=
LNCaP-Clone-FGC NITkdVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJ3LkO0PVgh|ryP M4LnTXNCVkeHUh?=
PA-1 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{eyeGlEPTB;MkWuOlg{OyEQvF2= NIqxR2RUSU6JRWK=
OE33 NEnrV2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJ3Lk[4OVMh|ryP MVfTRW5ITVJ?
HT-29 NIj3S4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPrSWdTUUN3ME2yOU44QDd7IN88US=> NWTDe5R[W0GQR1XS
RCM-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\pT2FKSzVyPUK1Mlk3PTZizszN MWDTRW5ITVJ?
NCI-H1522 M1HRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTNTWM2OD1{NT65PVEyKM7:TR?= M3XkVXNCVkeHUh?=
LB373-MEL-D M4DHSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJ4LkG3NFgh|ryP MnjmV2FPT0WU
NCI-H1436 NHPjVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\pclREUUN3ME2yOk4zPzN6IN88US=> NFHuV41USU6JRWK=
COLO-824 NGX4UnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJ4LkSwNFIh|ryP NUfWPFNQW0GQR1XS
CP50-MEL-B M{XWd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXCSoZKSzVyPUK2MlU3PzVizszN NXywWFhkW0GQR1XS
EGI-1 NGfTdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL4[Go5UUN3ME2yO{4zPjl6IN88US=> MWXTRW5ITVJ?
LAN-6 NV;QcWFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jiOmlEPTB;MkeuN|U6QCEQvF2= MY\TRW5ITVJ?
GAK MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nJVGlEPTB;MkeuOFIzPSEQvF2= MWLTRW5ITVJ?
MDA-MB-175-VII MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTJ5LkWwOVMh|ryP MYfTRW5ITVJ?
JVM-2 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HKSmlEPTB;MkeuOlYzOiEQvF2= M4jLcnNCVkeHUh?=
UACC-257 NYHYU4FrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;vOWlEPTB;MkeuOlg4QCEQvF2= MmXjV2FPT0WU
SW1783 NYjZR|NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrlSIlKSzVyPUK3Mlc4QDNizszN M3jJWXNCVkeHUh?=
HT-3 NGfiWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7IOHI4UUN3ME2yPE4zOTZ4IN88US=> M1vSU3NCVkeHUh?=
RL M2f2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn5eXpbUUN3ME2yPE42QTFzIN88US=> NXGyWXpMW0GQR1XS
TK10 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;UTI1TUUN3ME2yPE43PTN3IN88US=> NUfuXWdTW0GQR1XS
HT55 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i2V2lEPTB;MkmuNFU3PSEQvF2= M2OyZ3NCVkeHUh?=
BT-20 Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrsR5BKSzVyPUK5MlA2QDZizszN MmPuV2FPT0WU
TGBC24TKB MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3ue3ZKSzVyPUK5MlE5OzFizszN NF\sR3dUSU6JRWK=
HSC-2 NYXjUVNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJ7LkOwNFEh|ryP MlmwV2FPT0WU
COLO-205 NGOy[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH74cpJKSzVyPUK5MlM6PDRizszN MUjTRW5ITVJ?
GT3TKB M1vFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ7Lk[4O|ch|ryP M4TVVHNCVkeHUh?=
T47D MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU[1U3dwUUN3ME2yPU45PTh{IN88US=> NWHTeW5nW0GQR1XS
OMC-1 MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHiTWM2OD1|MD6xPVE6KM7:TR?= MnvVV2FPT0WU
PFSK-1 NHrSWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGGxcWZKSzVyPUOxMlI3PTlizszN MmTtV2FPT0WU
JEG-3 NYXyXYhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTNzLkO1OlEh|ryP MkHxV2FPT0WU
RD MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe4XG9oUUN3ME2zNU42OTF3IN88US=> M1X4T3NCVkeHUh?=
NCI-H64 Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfZWpp1UUN3ME2zNk41OTd7IN88US=> MWHTRW5ITVJ?
DMS-114 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj0TWM2OD1|Mj60NVgzKM7:TR?= NE\6SohUSU6JRWK=
NCI-H661 M4H5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HXVWlEPTB;M{KuOlUxOSEQvF2= MYPTRW5ITVJ?
CAL-148 NI\3eVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDFTWM2OD1|Mj62OlY2KM7:TR?= MYLTRW5ITVJ?
HuP-T3 Mn;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfoTWM2OD1|Mj65N|M5KM7:TR?= NFqxXoxUSU6JRWK=
ES4 NHHVW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljiTWM2OD1|Mz6xO|A2KM7:TR?= NXnmem5UW0GQR1XS
Ca9-22 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN|LkS2NFEh|ryP NFjDXWJUSU6JRWK=
LP-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLzS5NSUUN3ME2zOE4xQSEQvF2= M2TLcnNCVkeHUh?=
AU565 NEjOZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXNTWM2OD1|ND61NFY6KM7:TR?= M33hXnNCVkeHUh?=
MDA-MB-453 M3fZ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv1TWM2OD1|NT6xOFI3KM7:TR?= NF32Z4xUSU6JRWK=
SNU-C1 M4T0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN3LkG3NUDPxE1? MlPZV2FPT0WU
SW13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN3LkSwO|Yh|ryP NVnhXGlSW0GQR1XS
NCI-H2122 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDNR45KUUN3ME2zOU42PTl6IN88US=> MUDTRW5ITVJ?
NCI-H1395 NF\Yco1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN3Lk[2PVEh|ryP M2PScnNCVkeHUh?=
J-RT3-T3-5 NXvlPWMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvtTWM2OD1|Nj6wNlk1KM7:TR?= MkL5V2FPT0WU
COR-L279 NGHlSW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSwTWM2OD1|Nj6xPVgyKM7:TR?= Mle4V2FPT0WU
ATN-1 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PrT2lEPTB;M{[uPFUyPiEQvF2= M3jNdnNCVkeHUh?=
HCC2998 NGPydo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHhTWM2OD1|Nj64OVcyKM7:TR?= NV7xSXA{W0GQR1XS
UM-UC-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTN4Lki2O|Uh|ryP MlriV2FPT0WU
DV-90 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnviTWM2OD1|Nj65NFY4KM7:TR?= M37TfHNCVkeHUh?=
ES8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojrTWM2OD1|Nj65N|E5KM7:TR?= NVf1OYIzW0GQR1XS
YAPC NWfiZZJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfVO29HUUN3ME2zOk46PjV2IN88US=> NYjPbnJpW0GQR1XS
HCC1599 M4ixNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y2NmlEPTB;M{euNVYyQCEQvF2= M4ix[XNCVkeHUh?=
UMC-11 NGG4WGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml60TWM2OD1|Nz6yOVA{KM7:TR?= MoTVV2FPT0WU
THP-1 NYLsNIk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjDOIV[UUN3ME2zO{4zQDZ6IN88US=> NYDBZYdqW0GQR1XS
OCUB-M MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLJdoVDUUN3ME2zO{4zQDlzIN88US=> NUnydohkW0GQR1XS
NCI-H1693 NHfGc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXjTWM2OD1|Nz6zNlM{KM7:TR?= MoLkV2FPT0WU
NCI-H345 NE\T[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;oRmlbUUN3ME2zO{4{PjJ2IN88US=> NX7OSY91W0GQR1XS
COLO-800 M1rWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S0W2lEPTB;M{euOVY4KM7:TR?= MnvLV2FPT0WU
COLO-320-HSR NVnCN2tbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTN6LkO0PVIh|ryP NHPWd5VUSU6JRWK=
NCI-H596 NYXqXlhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTpZ21KSzVyPUO4MlQ1QDlizszN NYPiR|hWW0GQR1XS
NCI-H187 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN6LkezOFQh|ryP NIrRWJdUSU6JRWK=
ECC4 NXG0N2g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{SySmlEPTB;M{muNFgyPCEQvF2= MnLTV2FPT0WU
KP-4 NGPobZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33TNmlEPTB;M{muNVI{PSEQvF2= NULvWm55W0GQR1XS
NCI-H2227 NYj6TIk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTReohKSzVyPUO5MlM6PDlizszN NHX2SoFUSU6JRWK=
22RV1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\QOmlEPTB;M{muPFM6QCEQvF2= NV6wXmtiW0GQR1XS
SAS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTTNXhKSzVyPUSwMlA6PiEQvF2= NULTUG9qW0GQR1XS
PANC-10-05 M3nHV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfX[mExUUN3ME20NE4yQDJ6IN88US=> MlzpV2FPT0WU
MDA-MB-468 NXLD[5hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zxTmlEPTB;NECuOVM1PiEQvF2= MlHIV2FPT0WU
RPMI-7951 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jNVWlEPTB;NEGuNlA4PSEQvF2= NUTwW4k4W0GQR1XS
BB49-HNC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqwZol6UUN3ME20NU4zOTd7IN88US=> M3vjTHNCVkeHUh?=
23132-87 NGrqZZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkGzTWM2OD12MT6yO|MzKM7:TR?= Ml3OV2FPT0WU
HCC1569 NVLSVnpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jldWlEPTB;NEGuNlg5PSEQvF2= M1TicXNCVkeHUh?=
CP66-MEL NVnRb2ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYixXJVXUUN3ME20Nk4yQDh4IN88US=> NVXzNHZwW0GQR1XS
K-562 NGX4TnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonmTWM2OD12Mj6yPFU1KM7:TR?= NIjLTYtUSU6JRWK=
OCI-AML2 M3jWcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLX[Y46UUN3ME20Nk45QTd2IN88US=> MVrTRW5ITVJ?
SW756 Mn\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTR|LkCzPFgh|ryP NGrlUHBUSU6JRWK=
M14 MoniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTrPXJCUUN3ME20N{4{OTh7IN88US=> MWHTRW5ITVJ?
NCI-H1623 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSwVIR6UUN3ME20N{41PjRizszN NW[y[WtbW0GQR1XS
KNS-81-FD MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPSTWM2OD12Mz63OlIh|ryP M3zWPXNCVkeHUh?=
TGBC1TKB MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLC[IdKSzVyPUSzMlkxQTlizszN MlPHV2FPT0WU
RERF-LC-MS M{jqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPMTWM2OD12Mz65NlgyKM7:TR?= M3rLTXNCVkeHUh?=
PC-3 M1XtPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjhSGhKSzVyPUS0MlQ{PDdizszN NVv1RWFXW0GQR1XS
HuP-T4 NEf0SI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rzV2lEPTB;NESuOFQ4PCEQvF2= Mki4V2FPT0WU
NCI-H510A M320[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf0WVBYUUN3ME20OE44ODhizszN MVTTRW5ITVJ?
LB2518-MEL MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPMTWM2OD12ND63PVM4KM7:TR?= NYf6SZd1W0GQR1XS
TE-5 NX\vSodqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi3UJd1UUN3ME20OU46PThzIN88US=> M2XoOHNCVkeHUh?=
EW-24 M1zmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR4LkG3NlMh|ryP NVnNV5U3W0GQR1XS
LB647-SCLC MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HBNmlEPTB;NE[uNlE2PSEQvF2= M{n2OHNCVkeHUh?=
NCI-H524 NYC1V5pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvFTWM2OD12Nj63NVg2KM7:TR?= MX7TRW5ITVJ?
EW-11 M{LQWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHmxSopKSzVyPUS2Mlk{PzNizszN M{jmfHNCVkeHUh?=
KALS-1 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTR5LkKwOlYh|ryP NVnxWllXW0GQR1XS
BT-474 NH\EemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTR5LkSyNVYh|ryP M4LxO3NCVkeHUh?=
SK-N-AS MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTvTWM2OD12Nz64PFgh|ryP NW\wOJdMW0GQR1XS
HCC2157 M3fKZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK3TWM2OD12OD6wO|Yh|ryP MVvTRW5ITVJ?
HCC1954 M3;EXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDEVJBVUUN3ME20PE4yPzB2IN88US=> M3vxZ3NCVkeHUh?=
FADU M2nXN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDRTJgxUUN3ME20PE4{ODNzIN88US=> MkC3V2FPT0WU
S-117 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnmfoJMUUN3ME20PE4{QDF3IN88US=> NGiw[GFUSU6JRWK=
LS-1034 NIXRWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OwXGlEPTB;NEiuO|A3PyEQvF2= NILPcoFUSU6JRWK=
CAMA-1 NGDtOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj2[|RKSzVyPUS5MlU2PDNizszN NFf2SW9USU6JRWK=
LU-134-A MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnWVZJKSzVyPUS5MlgxQDVizszN M3TRZ3NCVkeHUh?=
NCI-H1838 M1;lZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTR7LkiwPFch|ryP MkL2V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04070443 Not yet recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard October 1 2019 Phase 2
NCT03934372 Not yet recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation October 25 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID