Ponatinib (AP24534)

For research use only. Not for use in humans.

Catalog No.S1490

83 publications

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Selleck's Ponatinib (AP24534) has been cited by 83 publications

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NGnQ[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TRXmlEPTB;MD6wNFAxODByM{W5JO69VQ>? NW\wRXVUW0GQR1XS
MV-4-11 M3v0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyyTWM2OD1yLkCwNFA6PTZizszN MmPBV2FPT0WU
MEG-01 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfu[|A5UUN3ME2wMlAxODF{ODFOwG0> Mmi0V2FPT0WU
LAMA-84 NGfjUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqwRm5LUUN3ME2wMlAxODF4NTFOwG0> MkfqV2FPT0WU
CGTH-W-1 NWixcJlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[yTWM2OD1yLkCwNVY6KM7:TR?= NXnSWWZ7W0GQR1XS
KASUMI-1 NIC1WnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi4cHVLUUN3ME2wMlAxOjF5IN88US=> NV\abmh3W0GQR1XS
BE-13 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y5U2lEPTB;MD6wNFI2QSEQvF2= Mn:3V2FPT0WU
CTV-1 M1P0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnT1TWM2OD1yLkCwOVIyKM7:TR?= NUHIdXhiW0GQR1XS
NKM-1 M{\iWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrqTWM2OD1yLkCwOlU2KM7:TR?= MV7TRW5ITVJ?
MONO-MAC-6 NGrSRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LNT2lEPTB;MD6wNFg{PyEQvF2= MUfTRW5ITVJ?
A204 NGXYZm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorDTWM2OD1yLkCxNlE5KM7:TR?= NGrwdG5USU6JRWK=
GDM-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHhdI5KSzVyPUCuNFE5OzNizszN M3nV[XNCVkeHUh?=
AN3-CA NXnkbYxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz2[lc6UUN3ME2wMlAyQDd|IN88US=> MmHWV2FPT0WU
BL-70 NGTYT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEKxPVkh|ryP NGLVTlJUSU6JRWK=
Daudi MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnHWpBKSzVyPUCuNFI2OzdizszN NILUdZRUSU6JRWK=
KU812 M1rNcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEK4OFgh|ryP MmHBV2FPT0WU
KG-1 NVrpR5ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnNNmZqUUN3ME2wMlA{Ojl2IN88US=> MYrTRW5ITVJ?
DOHH-2 M1uzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;NTWM2OD1yLkC0PFA{KM7:TR?= MWPTRW5ITVJ?
HuO9 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPXfmtUUUN3ME2wMlA2PDR6IN88US=> NIf6dnFUSU6JRWK=
EB2 NFfFVlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEW1O|Yh|ryP M4DmWXNCVkeHUh?=
G-402 NWKwdYhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwME[zOFEh|ryP MV\TRW5ITVJ?
SU-DHL-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPaTWM2OD1yLkC2N|c6KM7:TR?= NGW1OpNUSU6JRWK=
NCI-H719 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{S3SWlEPTB;MD6wO|g5QCEQvF2= NGHL[W1USU6JRWK=
MLMA NYWzNGJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjFZ497UUN3ME2wMlA6ODZizszN NHvIdZFUSU6JRWK=
KM12 NV;a[W56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPPTWM2OD1yLkC5O|M4KM7:TR?= NInwc4NUSU6JRWK=
SUP-T1 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\RcmlEPTB;MD6wPVk5OiEQvF2= NIfmZ5FUSU6JRWK=
MZ1-PC NILVNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P6NGlEPTB;MD6xNVM{PiEQvF2= MlLnV2FPT0WU
MFE-296 M{nEb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO3UGdrUUN3ME2wMlEyQDN7IN88US=> NGLze2dUSU6JRWK=
ALL-PO NULiU|NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHm[mdkUUN3ME2wMlEzPDR|IN88US=> MorqV2FPT0WU
GB-1 NHjCTIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnRWYV2UUN3ME2wMlEzPTF{IN88US=> MWnTRW5ITVJ?
SIG-M5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfP[lRZUUN3ME2wMlE{OzdizszN M{jJOHNCVkeHUh?=
P30-OHK NVW1d|lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUW2O|Ih|ryP M{jZdnNCVkeHUh?=
NCI-H716 NUPSR5pQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnRWY9QUUN3ME2wMlE3OjZ4IN88US=> M37vfnNCVkeHUh?=
MPP-89 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXaUHVKSzVyPUCuNVY6OzNizszN MUDTRW5ITVJ?
SF126 M4\JdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrmeZpOUUN3ME2wMlE4ODZ|IN88US=> MYTTRW5ITVJ?
CTB-1 M3KyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3YTWM2OD1yLkG3N|E3KM7:TR?= NYXtTnQyW0GQR1XS
CA46 Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLYXXpFUUN3ME2wMlE4PDh7IN88US=> NX\RWJkyW0GQR1XS
NCI-H520 NYHYeIpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMUe3N|Ih|ryP M2fRTXNCVkeHUh?=
CAL-85-1 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMUe5Nlch|ryP MkXDV2FPT0WU
NCI-H2342 MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfsZ4hKSzVyPUCuNVg2PzdizszN MWLTRW5ITVJ?
697 Mki1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3TWM2OD1yLkG4PFcyKM7:TR?= NV7BWlRqW0GQR1XS
NY M{nQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr2SWFFUUN3ME2wMlE6Ojh5IN88US=> NGPXNYZUSU6JRWK=
T98G MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q4bmlEPTB;MD6xPVMyQCEQvF2= NIrGcZJUSU6JRWK=
NCI-H1703 NXnXdG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PIcWlEPTB;MD6xPVYyPSEQvF2= NWDtVGd1W0GQR1XS
NCI-H2087 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fuSmlEPTB;MD6yNFQ{QSEQvF2= M3rxbXNCVkeHUh?=
PF-382 NGX5XINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDSOlEyUUN3ME2wMlIxQDd|IN88US=> MYHTRW5ITVJ?
HCT-116 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorvTWM2OD1yLkKxNFY6KM7:TR?= NUP4eHFQW0GQR1XS
CAKI-1 NGX1R2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jiS2lEPTB;MD6yNVY3PiEQvF2= MYrTRW5ITVJ?
CCF-STTG1 NFvqfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXZc3NUUUN3ME2wMlIzPDd3IN88US=> MknuV2FPT0WU
D-392MG NYLuT2M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj3S|ZKSzVyPUCuNlMyPzdizszN MYfTRW5ITVJ?
RT-112 NVnURWRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXztTHVjUUN3ME2wMlI{Pzl3IN88US=> MVXTRW5ITVJ?
MES-SA MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S2SGlEPTB;MD6yOFE5PyEQvF2= MWTTRW5ITVJ?
LC-2-ad M3LDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXZTWM2OD1yLkK0NlY2KM7:TR?= MmLkV2FPT0WU
NOS-1 NIf4SJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkSzOlch|ryP NVTYdG5sW0GQR1XS
NALM-6 NVLi[Fl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXYTWM2OD1yLkK1OVQ{KM7:TR?= MWHTRW5ITVJ?
TE-15 NHrxeXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGH3b3FKSzVyPUCuNlYxQTFizszN MUDTRW5ITVJ?
786-0 NFXsenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\uXJRKSzVyPUCuNlYzOjhizszN M4XvU3NCVkeHUh?=
IST-MES1 NWTRPGZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\STWM2OD1yLkK2PFI6KM7:TR?= MmW1V2FPT0WU
KYSE-180 NU\HRnlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\mO2lEPTB;MD6yOlg6OSEQvF2= M1\nZnNCVkeHUh?=
YT MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LlemlEPTB;MD6yOlk4PCEQvF2= NYDybZlqW0GQR1XS
A427 NYHqXI5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLDT4tnUUN3ME2wMlI4OjZ2IN88US=> MYfTRW5ITVJ?
KYSE-450 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXoWFk4UUN3ME2wMlI4OzJ7IN88US=> NEPQSotUSU6JRWK=
HuH-7 NXPLSnJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjHTWM2OD1yLkK3O|Y{KM7:TR?= MWLTRW5ITVJ?
CAS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfWWWlvUUN3ME2wMlI5OzB|IN88US=> NW[0eINwW0GQR1XS
KURAMOCHI M3S2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHrTWM2OD1yLkK4OFE6KM7:TR?= NEL1WVdUSU6JRWK=
ACHN NV7wbHR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HEbGlEPTB;MD6yPVMzOyEQvF2= M4nndnNCVkeHUh?=
HGC-27 NWfodmZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW3XXhXUUN3ME2wMlI6OzV|IN88US=> MljCV2FPT0WU
A172 M1\OXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r0N2lEPTB;MD6yPVU4PyEQvF2= M2f4THNCVkeHUh?=
SNU-449 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH6fG55UUN3ME2wMlI6QTZ2IN88US=> NIDaXJNUSU6JRWK=
SW982 M4i2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X6W2lEPTB;MD6yPVk4QCEQvF2= NE\yPWdUSU6JRWK=
EFO-21 NInOTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnCVGdKSzVyPUCuN|A1OTFizszN NHf4S3dUSU6JRWK=
NCI-H2030 NWjhNYdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzIfZJiUUN3ME2wMlMyOTZ2IN88US=> M4jabnNCVkeHUh?=
HT-144 NG\a[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvvSm95UUN3ME2wMlMyOjhizszN M2S5WnNCVkeHUh?=
MFE-280 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2K5NmlEPTB;MD6zNVQ2OyEQvF2= M3;EdXNCVkeHUh?=
SK-LU-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\2eXpuUUN3ME2wMlMyPDZ4IN88US=> M37leHNCVkeHUh?=
NCI-H2052 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\YS5dKSzVyPUCuN|E1QDRizszN NIPuTZlUSU6JRWK=
SK-HEP-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvyNoNyUUN3ME2wMlM{OzZ6IN88US=> M3rSeHNCVkeHUh?=
QIMR-WIL M2TxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwM{O0NlQh|ryP NF;RTWpUSU6JRWK=
A2780 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr4TWM2OD1yLkO0N|A1KM7:TR?= NWjkXZVxW0GQR1XS
ACN M3\BeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGyTWM2OD1yLkO0PFc{KM7:TR?= NVflOm1IW0GQR1XS
BxPC-3 NHvPRYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwM{S5PFkh|ryP MX\TRW5ITVJ?
BCPAP NYK5S29XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7PTWM2OD1yLkO2NFAyKM7:TR?= NV;mUmJ{W0GQR1XS
HOP-62 M4[4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLFTWM2OD1yLkO2NVA3KM7:TR?= MXnTRW5ITVJ?
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DBTRG-05MG MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH0RlhvUUN3ME2wMlM5ODV2IN88US=> NVi1XZNVW0GQR1XS
SK-MEL-24 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z3emlEPTB;MD6zPVc6OSEQvF2= MUnTRW5ITVJ?
8305C MoDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwM{m3PVMh|ryP MVTTRW5ITVJ?
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NCI-H747 NIeyfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TIcGlEPTB;MD60NlE{PyEQvF2= M3fPdnNCVkeHUh?=
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LCLC-97TM1 NHr6UI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LkVGlEPTB;MD60OlE6PSEQvF2= NHX3clRUSU6JRWK=
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L-428 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFwOUmxO|kh|ryP NF\hRWFUSU6JRWK=
KM-H2 MlqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvRZnlwUUN3ME2yMlAyODlizszN M4PU[3NCVkeHUh?=
MC-IXC M2ToSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG4[lZZUUN3ME2yMlAzOjd|IN88US=> MmnGV2FPT0WU
COLO-678 NYHmXXNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\STWM2OD1{LkC0NlA4KM7:TR?= M4T2Z3NCVkeHUh?=
MEL-JUSO NV3EcZpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\VNIt1UUN3ME2yMlA4QDVzIN88US=> NXrQfWROW0GQR1XS
HCC38 Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;VOmlEPTB;Mj6wPFQ{OyEQvF2= MVjTRW5ITVJ?
UACC-62 M2HzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJwMEi4OVUh|ryP NUTZVmExW0GQR1XS
OAW-42 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLvTWM2OD1{LkC5O|EyKM7:TR?= NEmyUlNUSU6JRWK=
LB996-RCC NELjTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHDW3RKSzVyPUKuNVM5OTdizszN M3;RSnNCVkeHUh?=
COR-L105 NX\JSJVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{noT2lEPTB;Mj6xOlM4OyEQvF2= MnO5V2FPT0WU
RCC10RGB MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn5VmVKSzVyPUKuNVg2PzZizszN NXPHeGMzW0GQR1XS
A431 NYe1SY1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwMUmwNVkh|ryP M4jLUHNCVkeHUh?=
NCI-H292 MmXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS5TWM2OD1{LkKzPVUyKM7:TR?= NV\1NZU6W0GQR1XS
SK-UT-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwM{OxPFQh|ryP NUHoT|czW0GQR1XS
PANC-08-13 NEPqelhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fZV2lEPTB;Mj6zN|I{PSEQvF2= NWjidHVrW0GQR1XS
ST486 NFvwd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXHTWM2OD1{LkSxNFQ5KM7:TR?= Mki1V2FPT0WU
SJSA-1 NE\RTnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT5V|VKSzVyPUKuOFEzPzFizszN MWrTRW5ITVJ?
RKO M{PndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwNEKwNlkh|ryP MUjTRW5ITVJ?
NCI-H1793 M2LuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P2SmlEPTB;Mj60OFAzQSEQvF2= M{fEfHNCVkeHUh?=
639-V NIq0cHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJwNEWzPFIh|ryP MWDTRW5ITVJ?
ES3 NITzWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwNEm3N|ch|ryP NGTuWZdUSU6JRWK=
NCI-H1792 NVHGdot4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwNU[4NlYh|ryP MXTTRW5ITVJ?
NCI-H1651 NXi2[4d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvaRmhKSzVyPUKuOVgzOSEQvF2= MUXTRW5ITVJ?
SN12C M3XjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLzTWM2OD1{LkW4OFg4KM7:TR?= MXzTRW5ITVJ?
COLO-679 NUK5dWNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPjOVBKSzVyPUKuOVg3ODVizszN MkT4V2FPT0WU
U-118-MG NES4VYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwNUi4O|Ih|ryP NXGyVVE4W0GQR1XS
Ramos-2G6-4C10 M3jBXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnofXlKSzVyPUKuOlQ5ODdizszN Ml;4V2FPT0WU
HCT-15 M3Xoemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PrdmlEPTB;Mj62PFc6OiEQvF2= MWjTRW5ITVJ?
MDA-MB-157 MmPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3yd5BKSzVyPUKuO|A4PDdizszN NWHTenRpW0GQR1XS
K5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELFc5RKSzVyPUKuO|E5PDVizszN NWDabo1kW0GQR1XS
MKN45 M3HS[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwN{OzOlYh|ryP MnW4V2FPT0WU
DMS-273 NYHiS5l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfmeFdGUUN3ME2yMlc2PjN{IN88US=> M{LZZnNCVkeHUh?=
C8166 NF7sV3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnyTW4zUUN3ME2yMlc5PTF|IN88US=> NGPBcWRUSU6JRWK=
Calu-3 NXHGfJZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{WwXGlEPTB;Mj63PFk3QSEQvF2= Mn;JV2FPT0WU
SNB75 M4\ONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrhTWM2OD1{Lki4OVM2KM7:TR?= Mn3XV2FPT0WU
BFTC-905 NWH2TlRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTJwOUCxPVEh|ryP NYTaRY5nW0GQR1XS
C-4-II MlvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJwOUGzOVMh|ryP MoXwV2FPT0WU
MS-1 NF;wRW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HzUGlEPTB;Mj65Olc3QSEQvF2= MnnwV2FPT0WU
A375 NIS5WVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwMEixPFQh|ryP M2[4c3NCVkeHUh?=
KYSE-70 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTTTWM2OD1|LkC4PFgzKM7:TR?= M3voRXNCVkeHUh?=
KYSE-510 NHzIPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXZTWM2OD1|LkGwPVk2KM7:TR?= MlfSV2FPT0WU
LN-405 MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHWSW1bUUN3ME2zMlE{PTF6IN88US=> NILNbYxUSU6JRWK=
BOKU M4\tW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7STWM2OD1|LkG0NlU3KM7:TR?= MUDTRW5ITVJ?
TE-10 M3XJ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\xTWM2OD1|LkG3N|YzKM7:TR?= NWTFUGhxW0GQR1XS
MKN1 NGXmN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\6UGlEPTB;Mz6xPFQ5OyEQvF2= M1eye3NCVkeHUh?=
M059J NUfFVZV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f4S2lEPTB;Mz6yNFE4OyEQvF2= NVnod5htW0GQR1XS
GOTO MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG5Xo9MUUN3ME2zMlIzODN7IN88US=> MX;TRW5ITVJ?
DK-MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwMkW5O|Yh|ryP Mlm5V2FPT0WU
NCI-H727 M1fEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInXdJlKSzVyPUOuNlY2QCEQvF2= NETZdI9USU6JRWK=
NB12 M4mxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHix[HhKSzVyPUOuN|MzOjRizszN NF;wWYdUSU6JRWK=
DOK M3i2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zTeGlEPTB;Mz6zOlE5PiEQvF2= NFXTWoFUSU6JRWK=
KYSE-410 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jqZmlEPTB;Mz6zOlI5PyEQvF2= M4PYd3NCVkeHUh?=
AM-38 Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjBfGlpUUN3ME2zMlM5ODVzIN88US=> MkHtV2FPT0WU
GR-ST MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnw[|FTUUN3ME2zMlQ2PzN{IN88US=> NGmxWVhUSU6JRWK=
D-247MG NFLJfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Txc2lEPTB;Mz60PFI3OyEQvF2= NUnCOYd3W0GQR1XS
TE-8 NX\JXFNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTNwNEmzN|Mh|ryP MkLYV2FPT0WU
LS-411N NF7FT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DKbmlEPTB;Mz60PVY6OiEQvF2= NUDaRXdyW0GQR1XS
SK-MES-1 NYHifWRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3MTWM2OD1|LkW2OFM{KM7:TR?= NFPqVolUSU6JRWK=
SF295 NV[xbppuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfxNmtYUUN3ME2zMlYyPTV{IN88US=> Ml35V2FPT0WU
SK-MEL-30 NFTFZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNwNkW5NlEh|ryP MVzTRW5ITVJ?
LB2241-RCC MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTYTY9KSzVyPUOuOlYzPiEQvF2= MnvuV2FPT0WU
PC-14 NIPBbXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG0boJKSzVyPUOuOlY1OzdizszN MULTRW5ITVJ?
EW-7 NHPPSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL5e3hKSzVyPUOuOlc3QTNizszN NWHOSoRlW0GQR1XS
NMC-G1 NW\0bWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j2PWlEPTB;Mz63NVg{PyEQvF2= MUnTRW5ITVJ?
TE-441-T M4\JPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPjTWM2OD1|LkezNFI5KM7:TR?= NIL1PIdUSU6JRWK=
NCI-H1618 NVXrd3hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXw[4RKSzVyPUOuPFE5PzVizszN NUf2OmkxW0GQR1XS
PANC-03-27 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nXTGlEPTB;Mz64NVkyPiEQvF2= M2fKVXNCVkeHUh?=
NCI-H2228 NWPJdYN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3DVmdnUUN3ME2zMlg{OTJ4IN88US=> M4C4bHNCVkeHUh?=
CAPAN-1 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrIPHpKSzVyPUOuPFcxODlizszN NFe0RWtUSU6JRWK=
KLE NYnBelExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnPTpFKSzVyPUOuPVA3PyEQvF2= MVXTRW5ITVJ?
Becker MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fGXWlEPTB;Mz65Nlg1QSEQvF2= Mom3V2FPT0WU
SK-PN-DW NYS3XoM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTRwMEe5O|Qh|ryP NYrjdnVkW0GQR1XS
Hs-578-T M4THVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HofGlEPTB;ND6wPFMxPiEQvF2= NF\ndGdUSU6JRWK=
RS4-11 NIn0bVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjXR2VwUUN3ME20MlEyOjV3IN88US=> MY\TRW5ITVJ?
D-502MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTRwMU[5PVch|ryP MkDSV2FPT0WU
GI-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X0O2lEPTB;ND6yPFI6QSEQvF2= MmjqV2FPT0WU
NCI-H209 MmHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV30T3pEUUN3ME20MlM{PzhizszN Ml7kV2FPT0WU
SK-OV-3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLmN3BuUUN3ME20MlQ5OTR7IN88US=> M4fncnNCVkeHUh?=
LOUCY NIjhXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVXmlEPTB;ND60PFQ{OiEQvF2= M{Ox[HNCVkeHUh?=
NCI-H69 M3LPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj2TWM2OD12LkWxO|k{KM7:TR?= MVTTRW5ITVJ?
SCC-9 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlG2TWM2OD12LkWzNVczKM7:TR?= NV;oOldvW0GQR1XS
NCI-H526 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLITWM2OD12LkW5Nlk{KM7:TR?= M{LPbHNCVkeHUh?=
NCI-H2170 M3O2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTRwNk[3O|Eh|ryP MmLrV2FPT0WU
SR NX:0fIxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf3TWM2OD12LkewNFQ5KM7:TR?= MVrTRW5ITVJ?
CMK Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TtSWlEPTB;ND63NlExOSEQvF2= NHLhWmZUSU6JRWK=
COLO-829 NYL1PGJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTRwN{ewOFMh|ryP NXHZXVB2W0GQR1XS
HuO-3N1 NGDDXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCyTWM2OD12LkizNlgyKM7:TR?= MWnTRW5ITVJ?
5637 M3nqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz1eGNxUUN3ME20MlkxPDh5IN88US=> MnS4V2FPT0WU
A253 NEGzOXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln2TWM2OD12Lkm3O|A5KM7:TR?= NWnZcphWW0GQR1XS
NB10 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTFUnhKSzVyPUWuNFc1QTdizszN MVjTRW5ITVJ?
SF539 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrFRYljUUN3ME21MlA6QTV7IN88US=> NWn1RlFOW0GQR1XS
HAL-01 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTVwMUS2OFUh|ryP NFXadW9USU6JRWK=
MHH-ES-1 NV7DOmw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\UR|NKSzVyPUWuNVY6OjVizszN NHfoNGlUSU6JRWK=
DEL NYPT[GJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnZTWM2OD13LkK3OVgzKM7:TR?= MYnTRW5ITVJ?
NCI-H1299 M33Y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HiZWlEPTB;NT6zOVAxPyEQvF2= MV\TRW5ITVJ?
ChaGo-K-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\GeXJKSzVyPUWuN|UyODdizszN NH;mVm1USU6JRWK=
HMV-II NXf4SnFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTWTWM2OD13LkO5OFMh|ryP NUH4TXhLW0GQR1XS
NB69 M1PvT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFznelRKSzVyPUWuN|k3OzFizszN MXTTRW5ITVJ?
NCI-H1882 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTVwNEOzOlQh|ryP NVz5TXVrW0GQR1XS
SNU-475 NV3YZVk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED3TI1KSzVyPUWuOFcyPzFizszN M4K0PHNCVkeHUh?=
RXF393 Mk\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\R[VY5UUN3ME21MlQ5PDl2IN88US=> MmqzV2FPT0WU
CAL-51 MlviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlmwTWM2OD13Lk[yPFU{KM7:TR?= NUnqN3h7W0GQR1XS
SW1573 MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPJdldKSzVyPUWuOlM2OzRizszN NWPOU3V3W0GQR1XS
GCT M{jOSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGO1eIZKSzVyPUWuO|U6OjlizszN MVHTRW5ITVJ?
COR-L88 NWjjN5hiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHoTWM2OD13Lke2PFQ3KM7:TR?= M13yd3NCVkeHUh?=
MDA-MB-134-VI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnnU4pKSzVyPUWuPFc2OzZizszN MlnJV2FPT0WU
NB5 NVvP[Fh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTVWlEPTB;NT65NlQ1KM7:TR?= NVHHOpdkW0GQR1XS
GMS-10 NXOyc4JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T5bmlEPTB;NT65Olg3OSEQvF2= NXPDOppVW0GQR1XS
CHP-212 NGfjWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf0ZmZsUUN3ME22MlQ5OjZ5IN88US=> M3vYdHNCVkeHUh?=
TE-11 NUfD[HFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPGcnZRUUN3ME22MlU2OTh{IN88US=> MlTBV2FPT0WU
SW962 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVS2NI05UUN3ME22MlY2Pzd2IN88US=> M4fQSXNCVkeHUh?=
MZ2-MEL MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fmNWlEPTB;Nj64NlAyOSEQvF2= M2Ds[3NCVkeHUh?=
C-33-A NHLQcpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXnXWZvUUN3ME22MlkyPjh6IN88US=> MV3TRW5ITVJ?
IGR-1 M4S1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTZwOUe4NlYh|ryP NEGySFhUSU6JRWK=
MOLT-4 NXS5eXMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDqZ3NKSzVyPUeuNVU1ODZizszN M3vSbXNCVkeHUh?=
NCI-H1650 MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W4Z2lEPTB;Nz6yO|A1PiEQvF2= NX7GZWVHW0GQR1XS
AsPC-1 MkG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO3d5dKSzVyPUeuNlg3ODVizszN NVni[FB1W0GQR1XS
SNU-C2B MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGqwNnVKSzVyPUeuNlk2PzFizszN M{TtU3NCVkeHUh?=
MKN7 NEO2N2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH1TWM2OD15LkO3NlM2KM7:TR?= Mn;DV2FPT0WU
SW620 NUL2ZmZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTdwM{iyNFUh|ryP NGPUVHhUSU6JRWK=
SK-MEL-28 Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTqUmEyUUN3ME23MlQxPzl6IN88US=> MlG3V2FPT0WU
TE-6 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHiSmlKSzVyPUeuOFQ6ODhizszN NVLBb5pxW0GQR1XS
D-263MG NIro[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjRPFNxUUN3ME23MlQ2PzZ{IN88US=> MlTLV2FPT0WU
NCI-H1355 NGXPOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfHTWM2OD15Lke3NFI6KM7:TR?= M1nQe3NCVkeHUh?=
DSH1 MlLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfOblhVUUN3ME23Mlc6PzZ{IN88US=> NEfZSI1USU6JRWK=
NCI-H460 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHpfpNYUUN3ME24MlAxPjl2IN88US=> NIPnUllUSU6JRWK=
NCI-H1563 NEj3SohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ix[mlEPTB;OD6wO|UxQCEQvF2= M{nCZXNCVkeHUh?=
SW948 M3Pv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIWzcYlKSzVyPUiuNVA4PDRizszN NWHKcJdvW0GQR1XS
LK-2 MoDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfvSlVvUUN3ME24MlEzQDN|IN88US=> NHHnbZBUSU6JRWK=
HT-1080 M1uzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRThwMUOxO|Uh|ryP MX\TRW5ITVJ?
NCI-H441 M{DNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmSzTWM2OD16LkG5N{DPxE1? Mlu2V2FPT0WU
HSC-4 M4PzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rhRmlEPTB;OD6yPFczKM7:TR?= NHXNbZFUSU6JRWK=
LXF-289 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\vTWM2OD16LkO1PVQ{KM7:TR?= M4fJSnNCVkeHUh?=
MRK-nu-1 M3fRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOzW3NKSzVyPUiuN|Y{ODRizszN MoHVV2FPT0WU
no-11 M4C3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH5d5Y6UUN3ME24MlQ4OTN|IN88US=> NEnIdlRUSU6JRWK=
SNU-387 Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRThwNkOyOFYh|ryP NE\aNIFUSU6JRWK=
Detroit562 NInQTItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PPemlEPTB;OD63OVQ2PSEQvF2= MUXTRW5ITVJ?
SW954 M1K4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFezW3dKSzVyPUiuO|Y5OzJizszN MUfTRW5ITVJ?
P12-ICHIKAWA NF;3dXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moj1TWM2OD16Lke4PVQh|ryP M2e1dnNCVkeHUh?=
TE-9 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TtdmlEPTB;OD64NVA3OiEQvF2= M1rDXXNCVkeHUh?=
NB13 NHG4bFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;yRmlEPTB;OD64N|c6PiEQvF2= NGLldFdUSU6JRWK=
BPH-1 M3Pne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRThwOEWwPFEh|ryP MkPVV2FPT0WU
KMOE-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH5VnF[UUN3ME24Mlg4QDl{IN88US=> NEHXPZdUSU6JRWK=
RPMI-8402 Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LENmlEPTB;OD64PVkzPiEQvF2= NXrMd5NiW0GQR1XS
OVCAR-3 NHTSUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn5TWM2OD16Lkm3O|MzKM7:TR?= NWW3R5pxW0GQR1XS
NCI-H2196 NIT6c4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnCcW0zUUN3ME24Mlk5PjB4IN88US=> NXHIPXRyW0GQR1XS
MZ7-mel M3vGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe1cIhKSzVyPUmuNFM1PiEQvF2= M4K0bHNCVkeHUh?=
GP5d MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTlwME[zNVMh|ryP MYjTRW5ITVJ?
NCI-N87 NWm0SHd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j0[GlEPTB;OT60OFc{OSEQvF2= MoP3V2FPT0WU
EW-16 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nJfWlEPTB;OT60OFg1QCEQvF2= NVTqN2NXW0GQR1XS
Calu-6 MnPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jEOmlEPTB;OT60PVcxOyEQvF2= M4XrT3NCVkeHUh?=
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CCRF-CEM NHzvdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[wdGZGUUN3ME25MlY5PzZ4IN88US=> M4jUfnNCVkeHUh?=
BC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTlwN{i5PUDPxE1? Mn;xV2FPT0WU
NCI-SNU-16 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDlTWM2OD17Lke5OFk2KM7:TR?= MVTTRW5ITVJ?
NCI-H28 NVTUNmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfleZdKSzVyPUmuPFQ6OzNizszN NHfWclZUSU6JRWK=
SBC-1 M33mbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLJT4pKSzVyPUGwMlA4OiEQvF2= NFPXXFdUSU6JRWK=
TUR MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3Ubpo5UUN3ME2xNE4yPjV5IN88US=> NFP1em1USU6JRWK=
MDA-MB-231 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jYR2lEPTB;MUCuNlEyPCEQvF2= M{nufHNCVkeHUh?=
C3A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULGUJh1UUN3ME2xNE4{OTd7IN88US=> MoriV2FPT0WU
SW1990 MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX32[W9CUUN3ME2xNE4{OjhizszN MUXTRW5ITVJ?
NCI-H1993 NIS3TXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof3TWM2OD1zMD61Olk{KM7:TR?= NF\2XY9USU6JRWK=
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OAW-28 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r0c2lEPTB;MUCuPVg5QCEQvF2= MWHTRW5ITVJ?
HN M4fRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TOSWlEPTB;MUGuNVE{OSEQvF2= MkjkV2FPT0WU
NCI-H1304 M1;COmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\MfYhKSzVyPUGxMlE2PzZizszN MVPTRW5ITVJ?
Daoy NI[1dVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIf3W4tKSzVyPUGxMlQ{OzZizszN NEPNdo1USU6JRWK=
VA-ES-BJ NH;RRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XxNGlEPTB;MUGuO|E6PSEQvF2= MX3TRW5ITVJ?
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VM-CUB-1 NF7ac2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFzLkmwPVEh|ryP M3;rTXNCVkeHUh?=
IPC-298 NHfXdJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFzLkmzPFMh|ryP MmDMV2FPT0WU
NCI-H2126 M4LYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrLfVRGUUN3ME2xNk4xOjF6IN88US=> MmS1V2FPT0WU
OVCAR-8 NHO2cIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF{LkGxOFEh|ryP NIXvcW1USU6JRWK=
SJRH30 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnvepBKSzVyPUGyMlIzQTlizszN NVPScmNFW0GQR1XS
DMS-53 Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\ZWo01UUN3ME2xNk4zPjR7IN88US=> M37aWHNCVkeHUh?=
NCI-H322M NVPwbG1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDWe285UUN3ME2xNk4{OzV5IN88US=> M4m0cHNCVkeHUh?=
RVH-421 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3wTHlKSzVyPUGyMlQ6ODRizszN M{TSOXNCVkeHUh?=
Raji MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q5XWlEPTB;MUKuOlE1KM7:TR?= MUXTRW5ITVJ?
MDA-MB-415 M1r3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF{Lk[0OFQh|ryP Mn7UV2FPT0WU
EFE-184 NGf4VVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4POdmlEPTB;MUKuO|ExPiEQvF2= M3;nbHNCVkeHUh?=
BFTC-909 MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF{LkmyOFch|ryP MkOzV2FPT0WU
BHY MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nyNGlEPTB;MUOuN|M6KM7:TR?= NXPnVpd[W0GQR1XS
YKG-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF|LkO3OFkh|ryP M1:3THNCVkeHUh?=
EW-3 M1njemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\HTWM2OD1zMz63NVY{KM7:TR?= NFvOfHFUSU6JRWK=
HCC1143 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTF|Lke0N|ch|ryP NE\GRZpUSU6JRWK=
REH M4\WUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoO2TWM2OD1zMz64PVgzKM7:TR?= MmjoV2FPT0WU
CESS M1TadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF|Lkm0PFkh|ryP MWXTRW5ITVJ?
EFM-19 NIP2dJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rRNGlEPTB;MUSuNVEyOiEQvF2= NWq1TJRCW0GQR1XS
U031 Mm\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLmSm85UUN3ME2xOE41ODh3IN88US=> MlLIV2FPT0WU
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A388 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n2R2lEPTB;MUSuO|U2PiEQvF2= MYDTRW5ITVJ?
KP-N-YS NVrRTW5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF2Lke3N{DPxE1? NWrpOoJ4W0GQR1XS
Capan-2 NXfRXW5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;uTWM2OD1zND63PFYh|ryP MoLtV2FPT0WU
SKG-IIIa NUTWS|kyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml75TWM2OD1zND64PFYzKM7:TR?= MXXTRW5ITVJ?
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BEN MkLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTF2Lkm3OlYh|ryP NGnxXo9USU6JRWK=
MC116 M1P2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvoVYJ6UUN3ME2xOU4yPTl7IN88US=> M{TjeXNCVkeHUh?=
IGROV-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF3LkKzNVch|ryP Moe1V2FPT0WU
NCI-H1648 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTF3LkWzNFUh|ryP MmKzV2FPT0WU
ABC-1 NWXpbpk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PuWGlEPTB;MUWuPFA{OyEQvF2= NEj5VWVUSU6JRWK=
EW-18 NELTSFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDkTWM2OD1zNT65PVc6KM7:TR?= NFvj[2JUSU6JRWK=
BC-3 M{PLPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXHWpdMUUN3ME2xOk4xPTZ{IN88US=> M4nXOXNCVkeHUh?=
NCI-H1437 NYGyb2ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTF4LkC2Olch|ryP M1;vR3NCVkeHUh?=
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TT NWC2cY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\BcGlEPTB;MU[uOVg5QCEQvF2= M{PoU3NCVkeHUh?=
KINGS-1 NHzn[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnnNFZzUUN3ME2xOk45Ojd|IN88US=> NVziWWpMW0GQR1XS
C32 NIXDRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojZTWM2OD1zNj65O|E4KM7:TR?= MXPTRW5ITVJ?
SBC-5 M3XUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPzTpJ1UUN3ME2xO{4yPDd7IN88US=> NHj4[m1USU6JRWK=
NB1 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmzOYxqUUN3ME2xO{4{OTh6IN88US=> NV\Wd3U1W0GQR1XS
EB-3 M1r5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP5XlVRUUN3ME2xO{42PzZizszN MYfTRW5ITVJ?
NCI-H748 NVj2TWRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF5LkewN|Uh|ryP NHjHTFJUSU6JRWK=
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WM-115 M{nJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjnN3pKSzVyPUG3MlgxQDVizszN M4G4bHNCVkeHUh?=
NCI-H226 NGHkdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTF5Lkm1OFYh|ryP NULkUm5kW0GQR1XS
CAL-33 NIfIZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17CWGlEPTB;MUiuNlc5OSEQvF2= NEXwRZNUSU6JRWK=
SCC-4 M3rJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Xh[WlEPTB;MUiuN|IzQSEQvF2= MWTTRW5ITVJ?
RMG-I MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPY[3ZKSzVyPUG4MlY6PDdizszN NIXyN|dUSU6JRWK=
KOSC-2 NX\LToNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn33TWM2OD1zOD63O|Q3KM7:TR?= MVXTRW5ITVJ?
A2058 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHaTWM2OD1zOD64NlU2KM7:TR?= NYr4UWVFW0GQR1XS
HCC70 M3faTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml62TWM2OD1zOT6zPFk1KM7:TR?= M2TU[nNCVkeHUh?=
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NCI-H650 MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFSyWW1KSzVyPUG5MlU5QTlizszN MUjTRW5ITVJ?
CAL-72 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfuTWM2OD1zOT62O|M4KM7:TR?= MmrTV2FPT0WU
L-363 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XxU2lEPTB;MkCuNFIyOiEQvF2= MXTTRW5ITVJ?
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PLC-PRF-5 M16xfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYruNJhGUUN3ME2yNE4{QTB4IN88US=> NUn1PFdSW0GQR1XS
SW1463 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVexe2xOUUN3ME2yNE41PTJ3IN88US=> M2DG[3NCVkeHUh?=
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DMS-79 NHS3WItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzyNnJGUUN3ME2yNE45PDlizszN NWfVb3l[W0GQR1XS
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CHP-126 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHZUWhKSzVyPUKxMlQ1PjJizszN M3e4enNCVkeHUh?=
SW837 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TkWGlEPTB;MkGuOFk{QSEQvF2= NU[5NGtnW0GQR1XS
SHP-77 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfBVZZKSzVyPUKxMlYyOjJizszN NFzYb5NUSU6JRWK=
DB MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJzLk[xOFIh|ryP NGPaO49USU6JRWK=
ES5 NVHNV4FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJzLk[4OlQh|ryP MVHTRW5ITVJ?
COR-L23 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jvUGlEPTB;MkGuPFA2OSEQvF2= NV\EU2FkW0GQR1XS
KU-19-19 NIH0TmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;VepRKSzVyPUKxMlg6QDJizszN M4rsfHNCVkeHUh?=
T84 NUTOfXZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XQTGlEPTB;MkGuPVgyQSEQvF2= NVnzbVNpW0GQR1XS
NCI-H630 NGfkXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJ{LkWzOlMh|ryP NWPqTGxuW0GQR1XS
LU-165 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHQfolKSzVyPUKyMlU2PCEQvF2= NFvkZYlUSU6JRWK=
COLO-792 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJ{LkexNVEh|ryP M4LjPXNCVkeHUh?=
CAL-62 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ{Lke1NVch|ryP M3rUeHNCVkeHUh?=
HCE-T NWTrVIhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ{Lki2NFYh|ryP NGj2fm9USU6JRWK=
BB65-RCC NYjtNVJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qwWGlEPTB;MkOuNFM1PCEQvF2= M4XrSHNCVkeHUh?=
SiHa NGPqbVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnVXGtDUUN3ME2yN{4{QTZ6IN88US=> MV;TRW5ITVJ?
NCI-H2081 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ2LkC2OFEh|ryP MkXYV2FPT0WU
U251 NVTRe5FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTrTWM2OD1{ND6wOlY5KM7:TR?= MX3TRW5ITVJ?
LoVo MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\KUGlEPTB;MkSuPVI5OiEQvF2= MkDoV2FPT0WU
GCIY M376Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTtTWM2OD1{NT6yPFc4KM7:TR?= MlvtV2FPT0WU
NUGC-3 M2jXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ3LkOzNVYh|ryP M1fOR3NCVkeHUh?=
LNCaP-Clone-FGC MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TxVWlEPTB;MkWuN|Q6QCEQvF2= MoDTV2FPT0WU
PA-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\4TWM2OD1{NT62PFM{KM7:TR?= MU\TRW5ITVJ?
OE33 NIfLV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrSWmU5UUN3ME2yOU43QDV|IN88US=> M3q3Z3NCVkeHUh?=
HT-29 NWLwUW43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\SeZRKSzVyPUK1Mlc5PzlizszN MkTKV2FPT0WU
RCM-1 MmrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;HW5NOUUN3ME2yOU46PjV4IN88US=> NFft[XRUSU6JRWK=
NCI-H1522 M3KwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PPTWlEPTB;MkWuPVkyOSEQvF2= NUjIWpBoW0GQR1XS
LB373-MEL-D NG\qRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPnTWM2OD1{Nj6xO|A5KM7:TR?= MoPuV2FPT0WU
NCI-H1436 M1vTXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ4LkK3N|gh|ryP MX3TRW5ITVJ?
COLO-824 NVziWHM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLWTWM2OD1{Nj60NFAzKM7:TR?= MWHTRW5ITVJ?
CP50-MEL-B NV;MVYhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PqTmlEPTB;Mk[uOVY4PSEQvF2= NVfFXlhlW0GQR1XS
EGI-1 NFexWmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPLS|lKSzVyPUK3MlI3QThizszN NIr2ZoNUSU6JRWK=
LAN-6 MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PUb2lEPTB;MkeuN|U6QCEQvF2= MYTTRW5ITVJ?
GAK M3fSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ5LkSyNlUh|ryP MkHZV2FPT0WU
MDA-MB-175-VII MnP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXpTWM2OD1{Nz61NFU{KM7:TR?= M1HhTnNCVkeHUh?=
JVM-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnPTWM2OD1{Nz62OlIzKM7:TR?= MnjGV2FPT0WU
UACC-257 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLpTWM2OD1{Nz62PFc5KM7:TR?= MmTXV2FPT0WU
SW1783 M13xUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;3UGFqUUN3ME2yO{44Pzh|IN88US=> MWTTRW5ITVJ?
HT-3 NFPLZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ6LkKxOlYh|ryP Ml3WV2FPT0WU
RL NX7IfHN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\zTZFKSzVyPUK4MlU6OTFizszN NIn2PZZUSU6JRWK=
TK10 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLIeZo{UUN3ME2yPE43PTN3IN88US=> Mof5V2FPT0WU
HT55 NXGy[5JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq5NlFjUUN3ME2yPU4xPTZ3IN88US=> NWjmN3VnW0GQR1XS
BT-20 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHVTWM2OD1{OT6wOVg3KM7:TR?= M4PsfXNCVkeHUh?=
TGBC24TKB NF\mSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:4SWlEPTB;MkmuNVg{OSEQvF2= NGjFU5FUSU6JRWK=
HSC-2 NFTCdIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrKb2hKSzVyPUK5MlMxODFizszN NXjzVVBrW0GQR1XS
COLO-205 M2TDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJ7LkO5OFQh|ryP MVfTRW5ITVJ?
GT3TKB MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJ7Lk[4O|ch|ryP MWrTRW5ITVJ?
T47D NVSyeZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nrTmlEPTB;MkmuPFU5OiEQvF2= NETLWIxUSU6JRWK=
OMC-1 NUfvcoJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYniZ5N5UUN3ME2zNE4yQTF7IN88US=> M{GxTXNCVkeHUh?=
PFSK-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX0Wm9xUUN3ME2zNU4zPjV7IN88US=> MYfTRW5ITVJ?
JEG-3 M2fiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXrTWM2OD1|MT6zOVYyKM7:TR?= M4HZU3NCVkeHUh?=
RD NFHQcGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnMTWM2OD1|MT61NVE2KM7:TR?= NUTXNGxnW0GQR1XS
NCI-H64 NXLJNpYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTN{LkSxO|kh|ryP NHr4[FhUSU6JRWK=
DMS-114 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGiyfIVKSzVyPUOyMlQyQDJizszN MlSxV2FPT0WU
NCI-H661 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;qfmlEPTB;M{KuOlUxOSEQvF2= MUjTRW5ITVJ?
CAL-148 Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL4Xnd6UUN3ME2zNk43PjZ3IN88US=> NUizRoE3W0GQR1XS
HuP-T3 M1zuOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz6WYNQUUN3ME2zNk46OzN6IN88US=> NWfobHpqW0GQR1XS
ES4 NFvUOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTN|LkG3NFUh|ryP Mk\RV2FPT0WU
Ca9-22 NF6yd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M324VmlEPTB;M{OuOFYxOSEQvF2= NH73UVlUSU6JRWK=
LP-1 MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDKTWM2OD1|ND6wPUDPxE1? MnPEV2FPT0WU
AU565 M3Tybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN2LkWwOlkh|ryP Mli1V2FPT0WU
MDA-MB-453 NF:yPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrGR3MyUUN3ME2zOU4yPDJ4IN88US=> M{PkVXNCVkeHUh?=
SNU-C1 MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPafFFUUUN3ME2zOU4yPzFizszN MkDXV2FPT0WU
SW13 NXjrTW44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN3LkSwO|Yh|ryP NFKyUXJUSU6JRWK=
NCI-H2122 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXniT3VSUUN3ME2zOU42PTl6IN88US=> NUi3elFHW0GQR1XS
NCI-H1395 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXqRZYyUUN3ME2zOU43PjlzIN88US=> MYTTRW5ITVJ?
J-RT3-T3-5 MkjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rzUGlEPTB;M{[uNFI6PCEQvF2= Ml7iV2FPT0WU
COR-L279 MoXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN4LkG5PFEh|ryP MVLTRW5ITVJ?
ATN-1 NGjiOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrSc4ZKSzVyPUO2Mlg2OTZizszN NIHvTYdUSU6JRWK=
HCC2998 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjj[2hKSzVyPUO2Mlg2PzFizszN MVrTRW5ITVJ?
UM-UC-3 NEHMT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\GfGlEPTB;M{[uPFY4PSEQvF2= MXnTRW5ITVJ?
DV-90 NYLXWWZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P0cmlEPTB;M{[uPVA3PyEQvF2= MlzZV2FPT0WU
ES8 MmXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu3cnFoUUN3ME2zOk46OzF6IN88US=> NX;JSY91W0GQR1XS
YAPC MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqzTWM2OD1|Nj65OlU1KM7:TR?= NW\FfJp3W0GQR1XS
HCC1599 NXPLVIdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfkdZB4UUN3ME2zO{4yPjF6IN88US=> NWfMXJE5W0GQR1XS
UMC-11 NHXZdHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7qWWJKSzVyPUO3MlI2ODNizszN M{C4fHNCVkeHUh?=
THP-1 NXzsVZgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXweVhKSzVyPUO3MlI5PjhizszN MWDTRW5ITVJ?
OCUB-M MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XyOGlEPTB;M{euNlg6OSEQvF2= M4GxPXNCVkeHUh?=
NCI-H1693 NInFVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\lTWM2OD1|Nz6zNlM{KM7:TR?= NH;0NGhUSU6JRWK=
NCI-H345 M1foRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXK0cFREUUN3ME2zO{4{PjJ2IN88US=> NH35TllUSU6JRWK=
COLO-800 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVH3VItOUUN3ME2zO{42PjdizszN MknLV2FPT0WU
COLO-320-HSR MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvMTWM2OD1|OD6zOFkzKM7:TR?= NWXsZ4hoW0GQR1XS
NCI-H596 Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHn0[mhKSzVyPUO4MlQ1QDlizszN MmHQV2FPT0WU
NCI-H187 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n0fGlEPTB;M{iuO|M1PCEQvF2= NYm5c2tsW0GQR1XS
ECC4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:2cWxoUUN3ME2zPU4xQDF2IN88US=> NIfSRZpUSU6JRWK=
KP-4 NUDUd5EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfGTWM2OD1|OT6xNlM2KM7:TR?= NH7TWolUSU6JRWK=
NCI-H2227 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDUR2w6UUN3ME2zPU4{QTR7IN88US=> M2ezdXNCVkeHUh?=
22RV1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn5boYyUUN3ME2zPU45Ozl6IN88US=> M1fYRnNCVkeHUh?=
SAS NHPkRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXafXIyUUN3ME20NE4xQTZizszN M2nnZnNCVkeHUh?=
PANC-10-05 MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT5TWM2OD12MD6xPFI5KM7:TR?= NH;LW2NUSU6JRWK=
MDA-MB-468 NI\odZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\jcGlEPTB;NECuOVM1PiEQvF2= NGrVcZJUSU6JRWK=
RPMI-7951 NUTRUYNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rlOWlEPTB;NEGuNlA4PSEQvF2= MkDxV2FPT0WU
BB49-HNC NIPTfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLyTWM2OD12MT6yNVc6KM7:TR?= NIm5TolUSU6JRWK=
23132-87 NW\aSWZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TKbWlEPTB;NEGuNlc{OiEQvF2= M3HoNHNCVkeHUh?=
HCC1569 NXu4PXFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTRzLkK4PFUh|ryP M1flfHNCVkeHUh?=
CP66-MEL NVv6flhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPwSGdKSzVyPUSyMlE5QDZizszN MVzTRW5ITVJ?
K-562 MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX4RZBvUUN3ME20Nk4zQDV2IN88US=> NG\kV|ZUSU6JRWK=
OCI-AML2 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTWcmRUUUN3ME20Nk45QTd2IN88US=> MXPTRW5ITVJ?
SW756 NYeyWpo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTMOoE1UUN3ME20N{4xOzh6IN88US=> MUDTRW5ITVJ?
M14 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHOTWM2OD12Mz6zNVg6KM7:TR?= NVTqdVZ[W0GQR1XS
NCI-H1623 NIHN[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;STWM2OD12Mz60OlQh|ryP MUjTRW5ITVJ?
KNS-81-FD MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrZTG5IUUN3ME20N{44PjJizszN M4PnV3NCVkeHUh?=
TGBC1TKB M{Lje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[xWW5UUUN3ME20N{46ODl7IN88US=> M2jle3NCVkeHUh?=
RERF-LC-MS NFXUfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LEdmlEPTB;NEOuPVI5OSEQvF2= M2iySnNCVkeHUh?=
PC-3 NFvPXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT5NHdKSzVyPUS0MlQ{PDdizszN NGPCc3ZUSU6JRWK=
HuP-T4 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDaTVA4UUN3ME20OE41PDd2IN88US=> M3vyS3NCVkeHUh?=
NCI-H510A NFrwVYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn2TWM2OD12ND63NFgh|ryP NXHOe3VWW0GQR1XS
LB2518-MEL NFjRZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTR2Lke5N|ch|ryP NEnsNodUSU6JRWK=
TE-5 NHrOdmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH1UmJKSzVyPUS1Mlk2QDFizszN Mn7mV2FPT0WU
EW-24 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXDTWM2OD12Nj6xO|I{KM7:TR?= MX3TRW5ITVJ?
LB647-SCLC NEXIdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTR4LkKxOVUh|ryP NVLFNpJ5W0GQR1XS
NCI-H524 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHzfWdCUUN3ME20Ok44OTh3IN88US=> NX\BNXE5W0GQR1XS
EW-11 M{Da[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13uPGlEPTB;NE[uPVM4OyEQvF2= Mlf0V2FPT0WU
KALS-1 NHqzZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37ISmlEPTB;NEeuNlA3PiEQvF2= NHTvVZhUSU6JRWK=
BT-474 M4fMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV22dJRQUUN3ME20O{41OjF4IN88US=> M3PoTHNCVkeHUh?=
SK-N-AS NWL6SmRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j6NWlEPTB;NEeuPFg5KM7:TR?= M3jkWnNCVkeHUh?=
HCC2157 M3voNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqweJd6UUN3ME20PE4xPzZizszN MXXTRW5ITVJ?
HCC1954 NEDRSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTR6LkG3NFQh|ryP M2njUnNCVkeHUh?=
FADU NYr4WWNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTR6LkOwN|Eh|ryP MWTTRW5ITVJ?
S-117 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzUe214UUN3ME20PE4{QDF3IN88US=> M2rXSHNCVkeHUh?=
LS-1034 M3ThTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfxZ5BvUUN3ME20PE44ODZ5IN88US=> MmCwV2FPT0WU
CAMA-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrEVJVOUUN3ME20PU42PTR|IN88US=> NXnWdZRGW0GQR1XS
LU-134-A MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3exeWlEPTB;NEmuPFA5PSEQvF2= NILZS2VUSU6JRWK=
NCI-H1838 NFXyO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PLNWlEPTB;NEmuPFA5PyEQvF2= MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A
Smiles CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04070443 Not yet recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard October 1 2019 Phase 2
NCT03934372 Not yet recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation October 25 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID