Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Cited by 31 Publications

6 Customer Reviews

  • Immunoblot of H23 cells treated with trametinib (25 nM), ponatinib (750 nM), or their combination for the times shown.

    Nature, 2016, 534(7609):647-51. Ponatinib (AP24534) purchased from Selleck.

     

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

  • Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

    The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

  • Western blot analysis of lysates of Ba/F3 cells expressing BCR/ABL and BCR/ABL-T315I using antibodies directed against: c-ABL, ABL-Y245 (anti-phospho-ABL), Crkl, phosphorylated Crkl, STAT5, phosphorylated STAT5 (anti-phospho-STAT5) and β-tubulin (anti-β-tubulin). Molecular mass references (kDa) are presented, and c-ABL and β-Tubulin were used as a loading control.

    Leukemia, 2015, 29(5):1104-14. Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NF\0XWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPYSIFbUUN3ME2wMlAxODByMECzOVkh|ryP NEPlZ3FUSU6JRWK=
MV-4-11 NHexUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMECwNFk2PiEQvF2= NFnRNJdUSU6JRWK=
MEG-01 NUO5PXNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XK[WlEPTB;MD6wNFAyOjhizszN NYTEe2ZuW0GQR1XS
LAMA-84 NXW5dlA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMECwNVY2KM7:TR?= MU\TRW5ITVJ?
CGTH-W-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r4T2lEPTB;MD6wNFE3QSEQvF2= NVzIdXNxW0GQR1XS
KASUMI-1 NXrkb4ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXMTWM2OD1yLkCwNlE4KM7:TR?= M4\mcXNCVkeHUh?=
BE-13 MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rhXGlEPTB;MD6wNFI2QSEQvF2= MnzuV2FPT0WU
CTV-1 NU\tSpdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTLTohKSzVyPUCuNFA2OjFizszN NFfnRWlUSU6JRWK=
NKM-1 NXjUVGQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PuSmlEPTB;MD6wNFY2PSEQvF2= MVjTRW5ITVJ?
MONO-MAC-6 M362VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC5UHdKSzVyPUCuNFA5OzdizszN MXPTRW5ITVJ?
A204 NXzEXnh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHW0PHNKSzVyPUCuNFEzOThizszN MVnTRW5ITVJ?
GDM-1 NW\aNWVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHlTWM2OD1yLkCxPFM{KM7:TR?= MnHEV2FPT0WU
AN3-CA MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfmfm5KSzVyPUCuNFE5PzNizszN Mm\TV2FPT0WU
BL-70 M{DBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\6cYdKSzVyPUCuNFIyQTlizszN MlPrV2FPT0WU
Daudi NFHjeXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXnXFJKSzVyPUCuNFI2OzdizszN M{\ad3NCVkeHUh?=
KU812 NIHSZYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEK4OFgh|ryP MWfTRW5ITVJ?
KG-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEOyPVQh|ryP MWTTRW5ITVJ?
DOHH-2 M1XrTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jU[2lEPTB;MD6wOFgxOyEQvF2= NXfpco5HW0GQR1XS
HuO9 NILIW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlThTWM2OD1yLkC1OFQ5KM7:TR?= NHzkZ|dUSU6JRWK=
EB2 NVTOZZlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvldlUyUUN3ME2wMlA2PTd4IN88US=> NXHjOok2W0GQR1XS
G-402 NWPpSlBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH2NZhIUUN3ME2wMlA3OzRzIN88US=> NVHkWZY4W0GQR1XS
SU-DHL-1 NYHsR5hNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LpbmlEPTB;MD6wOlM4QSEQvF2= MV3TRW5ITVJ?
NCI-H719 NUjyOGduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEe4PFgh|ryP M2DlTXNCVkeHUh?=
MLMA MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\Cc5FJUUN3ME2wMlA6ODZizszN NHf4V3NUSU6JRWK=
KM12 NYLqSpd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLFTWM2OD1yLkC5O|M4KM7:TR?= Mk\yV2FPT0WU
SUP-T1 NFLZbXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DENmlEPTB;MD6wPVk5OiEQvF2= MnjLV2FPT0WU
MZ1-PC MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHxeIhrUUN3ME2wMlEyOzN4IN88US=> M1XEO3NCVkeHUh?=
MFE-296 NIDVcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7zTZE6UUN3ME2wMlEyQDN7IN88US=> MoH3V2FPT0WU
ALL-PO NYjw[2FqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjsN2FOUUN3ME2wMlEzPDR|IN88US=> NHm0S2xUSU6JRWK=
GB-1 NWjtZpN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nyZWlEPTB;MD6xNlUyOiEQvF2= MX\TRW5ITVJ?
SIG-M5 M1L6cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMUOzO{DPxE1? NYrreHI6W0GQR1XS
P30-OHK MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrBTYM2UUN3ME2wMlE2Pjd{IN88US=> Mlm0V2FPT0WU
NCI-H716 NFTKUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q2[mlEPTB;MD6xOlI3PiEQvF2= NYnzVmhWW0GQR1XS
MPP-89 NFTrbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnPTWM2OD1yLkG2PVM{KM7:TR?= MXXTRW5ITVJ?
SF126 NUnFUVRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LaNmlEPTB;MD6xO|A3OyEQvF2= M1XWSnNCVkeHUh?=
CTB-1 NVnleWpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPndXRKSzVyPUCuNVc{OTZizszN NXmxfWs2W0GQR1XS
CA46 M33KfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrOXVBVUUN3ME2wMlE4PDh7IN88US=> MY\TRW5ITVJ?
NCI-H520 NXvw[Yl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMUe3N|Ih|ryP NHnTcppUSU6JRWK=
CAL-85-1 Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPvT3dKSzVyPUCuNVc6OjdizszN NYTMeGhmW0GQR1XS
NCI-H2342 M{\6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvzOVlKSzVyPUCuNVg2PzdizszN MnHlV2FPT0WU
697 NVvuSlBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMUi4O|Eh|ryP NUjGblgyW0GQR1XS
NY NHnSdYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonxTWM2OD1yLkG5Nlg4KM7:TR?= NYnzNZRCW0GQR1XS
T98G NFfOTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe3eok1UUN3ME2wMlE6OzF6IN88US=> M1;CR3NCVkeHUh?=
NCI-H1703 M{C1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTFTWM2OD1yLkG5OlE2KM7:TR?= MXPTRW5ITVJ?
NCI-H2087 NXvrUXR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XybGlEPTB;MD6yNFQ{QSEQvF2= NHr6T3dUSU6JRWK=
PF-382 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnBd4xKSzVyPUCuNlA5PzNizszN MUnTRW5ITVJ?
HCT-116 MnPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMkGwOlkh|ryP MknKV2FPT0WU
CAKI-1 NUXGZ3V2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;HZ2pqUUN3ME2wMlIyPjZ4IN88US=> MkO0V2FPT0WU
CCF-STTG1 M4nLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMkK0O|Uh|ryP MonvV2FPT0WU
D-392MG MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMkOxO|ch|ryP NYfkeYl2W0GQR1XS
RT-112 MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7ydoNMUUN3ME2wMlI{Pzl3IN88US=> MVvTRW5ITVJ?
MES-SA NFPwZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WzcmlEPTB;MD6yOFE5PyEQvF2= MoL4V2FPT0WU
LC-2-ad NEO4W5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL5TWM2OD1yLkK0NlY2KM7:TR?= NEC5NFZUSU6JRWK=
NOS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXrTWM2OD1yLkK0N|Y4KM7:TR?= NGH2OWlUSU6JRWK=
NALM-6 NF3nephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XOcWlEPTB;MD6yOVU1OyEQvF2= MYPTRW5ITVJ?
TE-15 NV\5SG1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKyTWM2OD1yLkK2NFkyKM7:TR?= NVvTcZR7W0GQR1XS
786-0 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMk[yNlgh|ryP NF3WTIdUSU6JRWK=
IST-MES1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXW3fG5XUUN3ME2wMlI3QDJ7IN88US=> M2izVXNCVkeHUh?=
KYSE-180 M2LkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M173TGlEPTB;MD6yOlg6OSEQvF2= NXm3cpo{W0GQR1XS
YT Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHMOFFKSzVyPUCuNlY6PzRizszN M1PaPHNCVkeHUh?=
A427 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn6TnVKSzVyPUCuNlczPjRizszN M{HpNnNCVkeHUh?=
KYSE-450 NXnC[FZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi3eI9JUUN3ME2wMlI4OzJ7IN88US=> M3HzXHNCVkeHUh?=
HuH-7 M2\0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMke3OlMh|ryP MlKxV2FPT0WU
CAS-1 NYnxO3E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[zTWM2OD1yLkK4N|A{KM7:TR?= NUG2N2syW0GQR1XS
KURAMOCHI MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHyTWM2OD1yLkK4OFE6KM7:TR?= M3u3OHNCVkeHUh?=
ACHN NYC3dJpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLsTWM2OD1yLkK5N|I{KM7:TR?= NHy1OplUSU6JRWK=
HGC-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS0TFZKSzVyPUCuNlk{PTNizszN MkfOV2FPT0WU
A172 M4PET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\xNJFKSzVyPUCuNlk2PzdizszN MVjTRW5ITVJ?
SNU-449 NX;uSlhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS0TWM2OD1yLkK5PVY1KM7:TR?= Mn3aV2FPT0WU
SW982 NVvDNFdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jjZWlEPTB;MD6yPVk4QCEQvF2= NEfp[pNUSU6JRWK=
EFO-21 MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLnTWM2OD1yLkOwOFEyKM7:TR?= M4H1enNCVkeHUh?=
NCI-H2030 NYrvfHR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\pb4lWUUN3ME2wMlMyOTZ2IN88US=> MWXTRW5ITVJ?
HT-144 NHPod4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\B[mlEPTB;MD6zNVI5KM7:TR?= NWjLd29QW0GQR1XS
MFE-280 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvsTWM2OD1yLkOxOFU{KM7:TR?= MVHTRW5ITVJ?
SK-LU-1 NXLIeYdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjOWXF7UUN3ME2wMlMyPDZ4IN88US=> NXPkVHd6W0GQR1XS
NCI-H2052 NFLrV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwM{G0PFQh|ryP M2XLWHNCVkeHUh?=
SK-HEP-1 NUjvXmdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwM{OzOlgh|ryP M4O3RnNCVkeHUh?=
QIMR-WIL MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFq2XIpKSzVyPUCuN|M1OjRizszN MnT5V2FPT0WU
A2780 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jafWlEPTB;MD6zOFMxPCEQvF2= NVnMN4I2W0GQR1XS
ACN Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2xSIlKSzVyPUCuN|Q5PzNizszN MlXOV2FPT0WU
BxPC-3 MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\3WlhKSzVyPUCuN|Q6QDlizszN NWX0[pg2W0GQR1XS
BCPAP NHnmUZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;YTWM2OD1yLkO2NFAyKM7:TR?= NW\t[nFMW0GQR1XS
HOP-62 NFrPVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjkbWhKSzVyPUCuN|YyODZizszN NVrLZVFYW0GQR1XS
SW1710 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi4RZp{UUN3ME2wMlM3PDV3IN88US=> NFS4[oNUSU6JRWK=
OPM-2 NYfOUo1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fGU2lEPTB;MD6zOlQ4OyEQvF2= NYiwNFQyW0GQR1XS
DBTRG-05MG NH;TOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7QTWM2OD1yLkO4NFU1KM7:TR?= MXrTRW5ITVJ?
SK-MEL-24 M1qydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwM{m3PVEh|ryP M2rtXXNCVkeHUh?=
8305C MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSwUXBKSzVyPUCuN|k4QTNizszN MYHTRW5ITVJ?
OVCAR-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPyRodqUUN3ME2wMlQyPTh4IN88US=> NVXLSXN3W0GQR1XS
HLE NXrJPWYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTJbVl2UUN3ME2wMlQyQDZizszN M2f6b3NCVkeHUh?=
NCI-H747 NIjUVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwNEKxN|ch|ryP MV3TRW5ITVJ?
SW780 NFXJcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L6dmlEPTB;MD60NlM1PiEQvF2= M1TzOnNCVkeHUh?=
KYSE-150 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[5WIpTUUN3ME2wMlQzPDF3IN88US=> M4S2Z3NCVkeHUh?=
H4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXLTGFiUUN3ME2wMlQzPDVzIN88US=> NXvxT5pHW0GQR1XS
SW1088 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNESzPUDPxE1? M1KyRXNCVkeHUh?=
SF268 M4n0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwNES4OkDPxE1? NYryfodRW0GQR1XS
RT4 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHTVG9KSzVyPUCuOFUyOTFizszN NV[xOJJNW0GQR1XS
NCI-H522 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnGTWM2OD1yLkS1Nlch|ryP MUnTRW5ITVJ?
LCLC-97TM1 NXu1fGJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\wNItmUUN3ME2wMlQ3OTl3IN88US=> MXvTRW5ITVJ?
CAL-39 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjrRY5ZUUN3ME2wMlQ3PTF7IN88US=> MknqV2FPT0WU
CAL-120 NEXLUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jbnk{UUN3ME2wMlQ4PjR|IN88US=> NUjzcGNDW0GQR1XS
ESS-1 MkX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPqTWM2OD1yLkS3PFIyKM7:TR?= MYrTRW5ITVJ?
KARPAS-45 M{Ozc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPIfHBKSzVyPUCuOFg6OzNizszN NH7QWVdUSU6JRWK=
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NCI-H810 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LRXWlEPTB;MT64NVYxPiEQvF2= NEHUcGdUSU6JRWK=
SK-NEP-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL5TWM2OD1zLkizO|Y4KM7:TR?= M4HhSHNCVkeHUh?=
D-542MG NYKwV5MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwOEW4OVEh|ryP MmK5V2FPT0WU
KNS-42 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVP6[Gw3UUN3ME2xMlg3OjZ4IN88US=> NH\DOllUSU6JRWK=
NCI-H2452 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFwOEmwO|Qh|ryP MorXV2FPT0WU
SK-MEL-2 M4HvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTmTWM2OD1zLkmwNlcyKM7:TR?= M{XReHNCVkeHUh?=
OVCAR-5 NEDFO2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H2dmlEPTB;MT65NFY4PSEQvF2= Mmr3V2FPT0WU
SNG-M NX[xO2t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwOUW4OVgh|ryP NF7DZ4JUSU6JRWK=
A673 M3TPfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjITWM2OD1zLkm3OVE3KM7:TR?= MnvrV2FPT0WU
L-428 NH\3V4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PobWlEPTB;MT65PVE4QSEQvF2= NGPibWJUSU6JRWK=
KM-H2 M1jHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJwMEGwPUDPxE1? MorRV2FPT0WU
MC-IXC MoO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7HTWM2OD1{LkCyNlc{KM7:TR?= NEiwPYNUSU6JRWK=
COLO-678 NGHFSVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfDWlMzUUN3ME2yMlA1OjB5IN88US=> M4jDUnNCVkeHUh?=
MEL-JUSO NWK1fHNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwMEe4OVEh|ryP MoDvV2FPT0WU
HCC38 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jIbmlEPTB;Mj6wPFQ{OyEQvF2= MnnqV2FPT0WU
UACC-62 NEj3XoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr4eJM6UUN3ME2yMlA5QDV3IN88US=> MVfTRW5ITVJ?
OAW-42 M4nHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv3TWM2OD1{LkC5O|EyKM7:TR?= MVjTRW5ITVJ?
LB996-RCC NGL5S3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPVRpVKSzVyPUKuNVM5OTdizszN M2Ln[nNCVkeHUh?=
COR-L105 NUPzXo9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7xTWM2OD1{LkG2N|c{KM7:TR?= M3fpcHNCVkeHUh?=
RCC10RGB NYfDV5RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXhTWM2OD1{LkG4OVc3KM7:TR?= MX\TRW5ITVJ?
A431 NVX5eJp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zVTGlEPTB;Mj6xPVAyQSEQvF2= NXTPZZAzW0GQR1XS
NCI-H292 MkftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\RR2lEPTB;Mj6yN|k2OSEQvF2= NGnsXGdUSU6JRWK=
SK-UT-1 NXXQO21tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vmfmlEPTB;Mj6zN|E5PCEQvF2= M1q4dHNCVkeHUh?=
PANC-08-13 NIDCcHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPTNYZKSzVyPUKuN|MzOzVizszN NVf0ZVVpW0GQR1XS
ST486 NV\MTJhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xp[GlEPTB;Mj60NVA1QCEQvF2= MYTTRW5ITVJ?
SJSA-1 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJwNEGyO|Eh|ryP NIP0Z2VUSU6JRWK=
RKO NVfib4xtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXIO2VKSzVyPUKuOFIxOjlizszN M{XSOXNCVkeHUh?=
NCI-H1793 M4PQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HmUGlEPTB;Mj60OFAzQSEQvF2= NUG5b2JLW0GQR1XS
639-V NEHnN3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJwNEWzPFIh|ryP M2TLO3NCVkeHUh?=
ES3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmzTWM2OD1{LkS5O|M4KM7:TR?= NXPpNlRwW0GQR1XS
NCI-H1792 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwNU[4NlYh|ryP MkTXV2FPT0WU
NCI-H1651 NYro[o84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzHR41lUUN3ME2yMlU5OjFizszN NGjH[m1USU6JRWK=
SN12C M2LKXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\HdlJVUUN3ME2yMlU5PDh5IN88US=> NELyTVRUSU6JRWK=
COLO-679 M2GzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\Oe2lEPTB;Mj61PFYxPSEQvF2= MWnTRW5ITVJ?
U-118-MG NWCycpJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwNUi4O|Ih|ryP MXXTRW5ITVJ?
Ramos-2G6-4C10 NES4fnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3HVVhPUUN3ME2yMlY1QDB5IN88US=> NGjPOXJUSU6JRWK=
HCT-15 NHO5W3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\TS5VPUUN3ME2yMlY5Pzl{IN88US=> MULTRW5ITVJ?
MDA-MB-157 M33adWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfsNGJKSzVyPUKuO|A4PDdizszN NU\IVIxyW0GQR1XS
K5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nWeWlEPTB;Mj63NVg1PSEQvF2= NU\RSnNnW0GQR1XS
MKN45 M1\lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe0TWlKSzVyPUKuO|M{PjZizszN M1KyenNCVkeHUh?=
DMS-273 MoTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrPcnNsUUN3ME2yMlc2PjN{IN88US=> Mkm5V2FPT0WU
C8166 M1vVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwN{i1NVMh|ryP M2PCWnNCVkeHUh?=
Calu-3 M{G2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF63[YVKSzVyPUKuO|g6PjlizszN NGTQN5FUSU6JRWK=
SNB75 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXOSpFKSzVyPUKuPFg2OzVizszN MnTBV2FPT0WU
BFTC-905 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fyVmlEPTB;Mj65NFE6OSEQvF2= NYLXdoZzW0GQR1XS
C-4-II MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[0TWM2OD1{LkmxN|U{KM7:TR?= NETsepdUSU6JRWK=
MS-1 M2TzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[zc2VGUUN3ME2yMlk3PzZ7IN88US=> MmTyV2FPT0WU
A375 NVTqOoxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNwMEixPFQh|ryP MWLTRW5ITVJ?
KYSE-70 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nobmlEPTB;Mz6wPFg5OiEQvF2= MX\TRW5ITVJ?
KYSE-510 MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrrTWM2OD1|LkGwPVk2KM7:TR?= MmXiV2FPT0WU
LN-405 MoHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTNwMUO1NVgh|ryP MUTTRW5ITVJ?
BOKU M1\ZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fBeGlEPTB;Mz6xOFI2PiEQvF2= NG\kXY9USU6JRWK=
TE-10 M{jxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmKyTWM2OD1|LkG3N|YzKM7:TR?= M1PlOXNCVkeHUh?=
MKN1 NHTkZ|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LXSGlEPTB;Mz6xPFQ5OyEQvF2= NVPpeJg4W0GQR1XS
M059J MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTNwMkCxO|Mh|ryP NFXT[5JUSU6JRWK=
GOTO MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTpTWM2OD1|LkKyNFM6KM7:TR?= MmjLV2FPT0WU
DK-MG NWnHZWlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13jWWlEPTB;Mz6yOVk4PiEQvF2= MUXTRW5ITVJ?
NCI-H727 NIjIdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnYSFdKUUN3ME2zMlI3PThizszN MYfTRW5ITVJ?
NB12 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLNTWM2OD1|LkOzNlI1KM7:TR?= NF\o[HlUSU6JRWK=
DOK NHvxcWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNwM{[xPFYh|ryP NXrHRlJ[W0GQR1XS
KYSE-410 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7jTWM2OD1|LkO2Nlg4KM7:TR?= NIHSV2lUSU6JRWK=
AM-38 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknVTWM2OD1|LkO4NFUyKM7:TR?= MXrTRW5ITVJ?
GR-ST M2[0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i2[WlEPTB;Mz60OVc{OiEQvF2= MVLTRW5ITVJ?
D-247MG M2nMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XncmlEPTB;Mz60PFI3OyEQvF2= MUjTRW5ITVJ?
TE-8 M2LZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTNwNEmzN|Mh|ryP NXy5PXAzW0GQR1XS
LS-411N NEHGXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfXTWM2OD1|LkS5OlkzKM7:TR?= M{G5RXNCVkeHUh?=
SK-MES-1 MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PGPWlEPTB;Mz61OlQ{OyEQvF2= MlzmV2FPT0WU
SF295 NUDoZms6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\BfodKSzVyPUOuOlE2PTJizszN NELXWWNUSU6JRWK=
SK-MEL-30 NV;IUGVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H6fWlEPTB;Mz62OVkzOSEQvF2= NEi0e|VUSU6JRWK=
LB2241-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfPOFlwUUN3ME2zMlY3OjZizszN NHLWOZFUSU6JRWK=
PC-14 M4HKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTNwNk[0N|ch|ryP NHToTXRUSU6JRWK=
EW-7 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jMWGlEPTB;Mz62O|Y6OyEQvF2= MV\TRW5ITVJ?
NMC-G1 NUK0[lNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fmTmlEPTB;Mz63NVg{PyEQvF2= MnfMV2FPT0WU
TE-441-T MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rTTmlEPTB;Mz63N|AzQCEQvF2= MWPTRW5ITVJ?
NCI-H1618 M3z1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTHW|dKSzVyPUOuPFE5PzVizszN MlTFV2FPT0WU
PANC-03-27 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXSTWM2OD1|LkixPVE3KM7:TR?= MmnEV2FPT0WU
NCI-H2228 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTvb4pKSzVyPUOuPFMyOjZizszN MYTTRW5ITVJ?
CAPAN-1 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNwOEewNFkh|ryP NHfVbYRUSU6JRWK=
KLE NYjCR2VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr1WIdPUUN3ME2zMlkxPjdizszN Mn\vV2FPT0WU
Becker NGLodm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX21NHFMUUN3ME2zMlkzQDR7IN88US=> MkfUV2FPT0WU
SK-PN-DW MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zQTWlEPTB;ND6wO|k4PCEQvF2= MVHTRW5ITVJ?
Hs-578-T MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\JWGNzUUN3ME20MlA5OzB4IN88US=> NH6ze5BUSU6JRWK=
RS4-11 NV;acZE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfHTWM2OD12LkGxNlU2KM7:TR?= MlyyV2FPT0WU
D-502MG NF23ZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXhb5dKSzVyPUSuNVY6QTdizszN MYDTRW5ITVJ?
GI-1 NXrXdGJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\jOW56UUN3ME20MlI5Ojl7IN88US=> NHSxXIVUSU6JRWK=
NCI-H209 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\CTWM2OD12LkOzO|gh|ryP NVnFe3RuW0GQR1XS
SK-OV-3 NFzaOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTRwNEixOFkh|ryP MlfFV2FPT0WU
LOUCY MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwNEi0N|Ih|ryP MmW4V2FPT0WU
NCI-H69 NV73OJd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv2bFFKSzVyPUSuOVE4QTNizszN M3SzOnNCVkeHUh?=
SCC-9 NEPQXGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\hTWM2OD12LkWzNVczKM7:TR?= NGCxZ3NUSU6JRWK=
NCI-H526 NYL3blFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe3VZRKSzVyPUSuOVkzQTNizszN Mn3VV2FPT0WU
NCI-H2170 NWPYWZVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRwNk[3O|Eh|ryP MV\TRW5ITVJ?
SR MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\rc2lEPTB;ND63NFA1QCEQvF2= MVPTRW5ITVJ?
CMK MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O1SWlEPTB;ND63NlExOSEQvF2= NFfDeWVUSU6JRWK=
COLO-829 M2LRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DPdGlEPTB;ND63O|A1OyEQvF2= NHHaPI9USU6JRWK=
HuO-3N1 NH7qXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j3TGlEPTB;ND64N|I5OSEQvF2= Mmj2V2FPT0WU
5637 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX5NFhRUUN3ME20MlkxPDh5IN88US=> NXnSNXJzW0GQR1XS
A253 NFzBd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\sTWM2OD12Lkm3O|A5KM7:TR?= MnzSV2FPT0WU
NB10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITsSZZKSzVyPUWuNFc1QTdizszN NVPjVWU3W0GQR1XS
SF539 NXWxS4NPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvoNWhKSzVyPUWuNFk6PTlizszN M3r0RXNCVkeHUh?=
HAL-01 NXTKPFFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLpTWM2OD13LkG0OlQ2KM7:TR?= MXTTRW5ITVJ?
MHH-ES-1 NFTwUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfzTWM2OD13LkG2PVI2KM7:TR?= NFKwV2pUSU6JRWK=
DEL NHrOSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwMke1PFIh|ryP MknyV2FPT0WU
NCI-H1299 M33lfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXLTWM2OD13LkO1NFA4KM7:TR?= NHviSWtUSU6JRWK=
ChaGo-K-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL6SmJLUUN3ME21MlM2OTB5IN88US=> M3z3NHNCVkeHUh?=
HMV-II NXj5fHZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fPTWlEPTB;NT6zPVQ{KM7:TR?= MVzTRW5ITVJ?
NB69 NEHXfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTVwM{m2N|Eh|ryP NEDOblVUSU6JRWK=
NCI-H1882 NIHNRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXiRW9WUUN3ME21MlQ{OzZ2IN88US=> MUnTRW5ITVJ?
SNU-475 NH7MN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnFSmJKSzVyPUWuOFcyPzFizszN NVfCOVlYW0GQR1XS
RXF393 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFj5[HdKSzVyPUWuOFg1QTRizszN NXP4fHRXW0GQR1XS
CAL-51 MmLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHITWM2OD13Lk[yPFU{KM7:TR?= NV62dGVNW0GQR1XS
SW1573 M1Pibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\hb2x6UUN3ME21MlY{PTN2IN88US=> NELSeVVUSU6JRWK=
GCT MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTVwN{W5Nlkh|ryP MUTTRW5ITVJ?
COR-L88 NI\2OW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXjTWM2OD13Lke2PFQ3KM7:TR?= M2\R[XNCVkeHUh?=
MDA-MB-134-VI NVruO4lZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknXTWM2OD13Lki3OVM3KM7:TR?= NEe2WJNUSU6JRWK=
NB5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XBdmlEPTB;NT65NlQ1KM7:TR?= MlPWV2FPT0WU
GMS-10 NXH0N5g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET1XGJKSzVyPUWuPVY5PjFizszN Ml6zV2FPT0WU
CHP-212 M3\Bb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfP[m1KSzVyPU[uOFgzPjdizszN MXXTRW5ITVJ?
TE-11 NEDn[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT2S4dKSzVyPU[uOVUyQDJizszN M376O3NCVkeHUh?=
SW962 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTZwNkW3O|Qh|ryP NFX0ZmpUSU6JRWK=
MZ2-MEL NFzxTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;6TWM2OD14LkiyNFEyKM7:TR?= MYrTRW5ITVJ?
C-33-A MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO0[YFDUUN3ME22MlkyPjh6IN88US=> NW\3bWZwW0GQR1XS
IGR-1 NXu3b3NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSzbndKSzVyPU[uPVc5OjZizszN Mn7qV2FPT0WU
MOLT-4 MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2[xdGlEPTB;Nz6xOVQxPiEQvF2= MkLCV2FPT0WU
NCI-H1650 NYC3em8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTdwMkewOFYh|ryP NXG4clR6W0GQR1XS
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SK-MEL-28 M4P2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTdwNEC3PVgh|ryP MYTTRW5ITVJ?
TE-6 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi2SW94UUN3ME23MlQ1QTB6IN88US=> M3Gx[XNCVkeHUh?=
D-263MG M2TyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPJTWM2OD15LkS1O|YzKM7:TR?= NH3iVYxUSU6JRWK=
NCI-H1355 NGPZbI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTdwN{ewNlkh|ryP MVPTRW5ITVJ?
DSH1 M3LLdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrDc4tCUUN3ME23Mlc6PzZ{IN88US=> NH7YfFRUSU6JRWK=
NCI-H460 M4\tb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHrTWM2OD16LkCwOlk1KM7:TR?= MnnzV2FPT0WU
NCI-H1563 M4fM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nVfWlEPTB;OD6wO|UxQCEQvF2= NH3sZXlUSU6JRWK=
SW948 Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3TV|NqUUN3ME24MlExPzR2IN88US=> NUTtWoJJW0GQR1XS
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HT-1080 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRThwMUOxO|Uh|ryP Mn3FV2FPT0WU
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HSC-4 NGG1OmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDBTWM2OD16LkK4O|Ih|ryP MUnTRW5ITVJ?
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Detroit562 M2LTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLZXVhKSzVyPUiuO|U1PTVizszN M{HpOnNCVkeHUh?=
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P12-ICHIKAWA NF\5bmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRThwN{i5OEDPxE1? M2Hwd3NCVkeHUh?=
TE-9 M{DPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRThwOEGwOlIh|ryP NEL0[FVUSU6JRWK=
NB13 NF\iVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uz[WlEPTB;OD64N|c6PiEQvF2= NXnqVFlCW0GQR1XS
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OVCAR-3 NXXTNnZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjY[4VKSzVyPUiuPVc4OzJizszN NVj1b4p3W0GQR1XS
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NCI-N87 M3WwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4KwcGlEPTB;OT60OFc{OSEQvF2= M3HKZnNCVkeHUh?=
EW-16 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX4VIxKSzVyPUmuOFQ5PDhizszN NXXBNHo{W0GQR1XS
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BC-1 NYLy[oxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDCTWM2OD17Lke4PVkh|ryP MXzTRW5ITVJ?
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NCI-H28 NFr6RZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjlTWM2OD17Lki0PVM{KM7:TR?= M1:wN3NCVkeHUh?=
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TUR NWnDNJc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr5[Yk6UUN3ME2xNE4yPjV5IN88US=> NVPyVVVDW0GQR1XS
MDA-MB-231 NXv2dXdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXXOpp2UUN3ME2xNE4zOTF2IN88US=> M4LaN3NCVkeHUh?=
C3A NH\FbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;FVmlEPTB;MUCuN|E4QSEQvF2= NFmwTXhUSU6JRWK=
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NCI-H1993 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr5TWM2OD1zMD61Olk{KM7:TR?= M4XT[nNCVkeHUh?=
SK-CO-1 NFHIbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfLTlJKSzVyPUGwMlc4PyEQvF2= MYfTRW5ITVJ?
OAW-28 NWC5T4JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFyLkm4PFgh|ryP NH7wWm9USU6JRWK=
HN M{fq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f1W2lEPTB;MUGuNVE{OSEQvF2= M1fPZXNCVkeHUh?=
NCI-H1304 M1XINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz4V2ViUUN3ME2xNU4yPTd4IN88US=> NWrleXZCW0GQR1XS
Daoy M3XUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvpTWM2OD1zMT60N|M3KM7:TR?= MnH6V2FPT0WU
VA-ES-BJ NXvOPHN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX3dJBNUUN3ME2xNU44OTl3IN88US=> NXPKNZlVW0GQR1XS
MCF7 NVv1c491T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILoUGVKSzVyPUGxMlgyOjZizszN MnrIV2FPT0WU
VM-CUB-1 M4Xqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fwcmlEPTB;MUGuPVA6OSEQvF2= Ml7sV2FPT0WU
IPC-298 M1XSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL2Tpd{UUN3ME2xNU46Ozh|IN88US=> NV3DSnhvW0GQR1XS
NCI-H2126 M2PNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzOcllKSzVyPUGyMlAzOThizszN MkH3V2FPT0WU
OVCAR-8 NITDW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHseYxKSzVyPUGyMlEyPDFizszN MmTiV2FPT0WU
SJRH30 NHuzN2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTF{LkKyPVkh|ryP NEXXS2dUSU6JRWK=
DMS-53 M2rIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjEeI06UUN3ME2xNk4zPjR7IN88US=> NIGzVoVUSU6JRWK=
NCI-H322M NYGwZohDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLWTWM2OD1zMj6zN|U4KM7:TR?= NXqzOlV[W0GQR1XS
RVH-421 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzkd5J2UUN3ME2xNk41QTB2IN88US=> MU\TRW5ITVJ?
Raji NFX6Vo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jKbWlEPTB;MUKuOlE1KM7:TR?= NGf4UHhUSU6JRWK=
MDA-MB-415 NIDkeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTF{Lk[0OFQh|ryP M13ONHNCVkeHUh?=
EFE-184 M1G0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFm5cnVKSzVyPUGyMlcyODZizszN NYfW[3lEW0GQR1XS
BFTC-909 NWO2dow1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33IZ2lEPTB;MUKuPVI1PyEQvF2= MlHxV2FPT0WU
BHY MmrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfOeYpRUUN3ME2xN{4{OzlizszN NVG0RYFWW0GQR1XS
YKG-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DNcGlEPTB;MUOuN|c1QSEQvF2= NIjJdWtUSU6JRWK=
EW-3 M4n5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjhcnVQUUN3ME2xN{44OTZ|IN88US=> M3LwT3NCVkeHUh?=
HCC1143 M1HuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq4TWM2OD1zMz63OFM4KM7:TR?= M3PVcXNCVkeHUh?=
REH NYjPWI4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLJPXhLUUN3ME2xN{45QTh{IN88US=> Mln2V2FPT0WU
CESS M{mxdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDnXmViUUN3ME2xN{46PDh7IN88US=> MlqwV2FPT0WU
EFM-19 NYf0dFluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Phd2lEPTB;MUSuNVEyOiEQvF2= M1exPHNCVkeHUh?=
U031 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnLTWM2OD1zND60NFg2KM7:TR?= NW\KeppvW0GQR1XS
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LOXIMVI M3ruc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF2LkewOlgh|ryP NYLTUnNRW0GQR1XS
A388 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3iTWM2OD1zND63OVU3KM7:TR?= NXP5fnN1W0GQR1XS
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Capan-2 MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu4emlKSzVyPUG0Mlc5PiEQvF2= MYHTRW5ITVJ?
SKG-IIIa NWTUS|NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnETWM2OD1zND64PFYzKM7:TR?= M3LsZ3NCVkeHUh?=
HEL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLE[otKSzVyPUG0Mlg6QTdizszN M3PKV3NCVkeHUh?=
BEN NXP6fo1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXhTWM2OD1zND65O|Y3KM7:TR?= NHX1XnVUSU6JRWK=
MC116 M4CzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPpTWM2OD1zNT6xOVk6KM7:TR?= MYrTRW5ITVJ?
IGROV-1 M1m2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi3TWM2OD1zNT6yN|E4KM7:TR?= MlrmV2FPT0WU
NCI-H1648 NVr5[3piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPBTWM2OD1zNT61N|A2KM7:TR?= NWO0bmdXW0GQR1XS
ABC-1 MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjx[FR5UUN3ME2xOU45ODN|IN88US=> MkK4V2FPT0WU
EW-18 NIHtfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjGTWM2OD1zNT65PVc6KM7:TR?= Ml2yV2FPT0WU
BC-3 M4XkVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\VPVN7UUN3ME2xOk4xPTZ{IN88US=> MVrTRW5ITVJ?
NCI-H1437 M4fRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjubHZFUUN3ME2xOk4xPjZ5IN88US=> NV;4TXZnW0GQR1XS
SCC-15 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHqTWM2OD1zNj6yPFI2KM7:TR?= M3HOfnNCVkeHUh?=
TT NY[xc4sxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLTWGZWUUN3ME2xOk42QDh6IN88US=> Mmm2V2FPT0WU
KINGS-1 NF30[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT1cIhFUUN3ME2xOk45Ojd|IN88US=> NVHUbnRtW0GQR1XS
C32 NX3UbVRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHBeVBKSzVyPUG2Mlk4OTdizszN MXXTRW5ITVJ?
SBC-5 M3\5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLoTWM2OD1zNz6xOFc6KM7:TR?= MonEV2FPT0WU
NB1 M4qwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jlU2lEPTB;MUeuN|E5QCEQvF2= MoPoV2FPT0WU
EB-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTF5LkW3OkDPxE1? MkXiV2FPT0WU
NCI-H748 M1XEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPrTWM2OD1zNz63NFM2KM7:TR?= M1LMZXNCVkeHUh?=
IST-SL1 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWxcVVLUUN3ME2xO{44PTJ4IN88US=> NFzHO|JUSU6JRWK=
WM-115 M4rrXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr1eYdKSzVyPUG3MlgxQDVizszN NXvxNZBNW0GQR1XS
NCI-H226 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvVTWM2OD1zNz65OVQ3KM7:TR?= MWTTRW5ITVJ?
CAL-33 M3vIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH1U3lKSzVyPUG4MlI4QDFizszN NXzzSFV2W0GQR1XS
SCC-4 NIjqSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVO1coNIUUN3ME2xPE4{OjJ7IN88US=> NETY[odUSU6JRWK=
RMG-I MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT1TWM2OD1zOD62PVQ4KM7:TR?= Mm\oV2FPT0WU
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A2058 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6zT4w5UUN3ME2xPE45OjV3IN88US=> NEjZSHJUSU6JRWK=
HCC70 M3HG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rHPGlEPTB;MUmuN|g6PCEQvF2= NXfIZ3JJW0GQR1XS
C2BBe1 NUfoPI1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfUTWM2OD1zOT60NVQ5KM7:TR?= M1LQc3NCVkeHUh?=
NCI-H650 M3T2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUG2OYVKUUN3ME2xPU42QDl7IN88US=> M{Xx[nNCVkeHUh?=
CAL-72 M1HkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF7Lk[3N|ch|ryP NHywRW9USU6JRWK=
L-363 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjWeWZvUUN3ME2yNE4xOjF{IN88US=> M1\CSXNCVkeHUh?=
SNU-423 NGXlfnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXyd2NbUUN3ME2yNE4yODR|IN88US=> M1\w[HNCVkeHUh?=
PLC-PRF-5 MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJyLkO5NFYh|ryP M4XXcnNCVkeHUh?=
SW1463 NH7iZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET1eIVKSzVyPUKwMlQ2OjVizszN MWTTRW5ITVJ?
769-P MkfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJyLk[3Olkh|ryP MWPTRW5ITVJ?
DMS-79 M1jnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJyLki0PUDPxE1? MnSxV2FPT0WU
Saos-2 NXTTO2FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[4VHVzUUN3ME2yNE46PTV4IN88US=> M2n6SXNCVkeHUh?=
CHP-126 NV;qXWtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X3OGlEPTB;MkGuOFQ3OiEQvF2= MYrTRW5ITVJ?
SW837 NGLrdJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfRVZJIUUN3ME2yNU41QTN7IN88US=> MnLPV2FPT0WU
SHP-77 NFzVRmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ldpBKSzVyPUKxMlYyOjJizszN MX3TRW5ITVJ?
DB Mn\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvFXVJuUUN3ME2yNU43OTR{IN88US=> NXnBSGFLW0GQR1XS
ES5 NVi2NYkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln2TWM2OD1{MT62PFY1KM7:TR?= NGHLW2JUSU6JRWK=
COR-L23 MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmyUIU2UUN3ME2yNU45ODVzIN88US=> NXjFRZpiW0GQR1XS
KU-19-19 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJzLki5PFIh|ryP MYXTRW5ITVJ?
T84 M{DaNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLRc2dKSzVyPUKxMlk5OTlizszN MU\TRW5ITVJ?
NCI-H630 NUTGeIFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES1ZZpKSzVyPUKyMlU{PjNizszN NHXtN4hUSU6JRWK=
LU-165 NEnXRYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT4Vmh7UUN3ME2yNk42PTRizszN MU\TRW5ITVJ?
COLO-792 M1jwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrCe3RKSzVyPUKyMlcyOTFizszN M3\w[nNCVkeHUh?=
CAL-62 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vWRWlEPTB;MkKuO|UyPyEQvF2= NIDGUopUSU6JRWK=
HCE-T M3TKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnyeYxQUUN3ME2yNk45PjB4IN88US=> Mkf4V2FPT0WU
BB65-RCC M4PiSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETXO3pKSzVyPUKzMlA{PDRizszN Mn[1V2FPT0WU
SiHa MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLwTWM2OD1{Mz6zPVY5KM7:TR?= M2LkSHNCVkeHUh?=
NCI-H2081 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvNTWM2OD1{ND6wOlQyKM7:TR?= NVPRXW5lW0GQR1XS
U251 MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJ2LkC2Olgh|ryP NHLafVRUSU6JRWK=
LoVo MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3FTWM2OD1{ND65NlgzKM7:TR?= M4i2bHNCVkeHUh?=
GCIY NGTBOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTJ3LkK4O|ch|ryP NI\BS3JUSU6JRWK=
NUGC-3 NWDvNIM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHWR216UUN3ME2yOU4{OzF4IN88US=> NYqxS4ozW0GQR1XS
LNCaP-Clone-FGC M1Hu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nxSGlEPTB;MkWuN|Q6QCEQvF2= MlPtV2FPT0WU
PA-1 M2HPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL4dmxKSzVyPUK1MlY5OzNizszN NWnyNWlLW0GQR1XS
OE33 NG\MS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqzelBKSzVyPUK1MlY5PTNizszN M3rre3NCVkeHUh?=
HT-29 M33qTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H5UGlEPTB;MkWuO|g4QSEQvF2= MkXIV2FPT0WU
RCM-1 NV\nNoE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ3Lkm2OVYh|ryP NIXsPWpUSU6JRWK=
NCI-H1522 M{fMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPweo9SUUN3ME2yOU46QTFzIN88US=> NXLkPZBKW0GQR1XS
LB373-MEL-D NHnxWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3mTWM2OD1{Nj6xO|A5KM7:TR?= MWjTRW5ITVJ?
NCI-H1436 NGfCdW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fNd2lEPTB;Mk[uNlc{QCEQvF2= MWnTRW5ITVJ?
COLO-824 NHe5[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ4LkSwNFIh|ryP NHG2U2tUSU6JRWK=
CP50-MEL-B Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnWOJUyUUN3ME2yOk42Pjd3IN88US=> M3HHSXNCVkeHUh?=
EGI-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ5LkK2PVgh|ryP M1PydnNCVkeHUh?=
LAN-6 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrQOItKSzVyPUK3MlM2QThizszN M{GxS3NCVkeHUh?=
GAK MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7xTo5KSzVyPUK3MlQzOjVizszN M2PMcnNCVkeHUh?=
MDA-MB-175-VII NGLxSolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\E[mlEPTB;MkeuOVA2OyEQvF2= MWHTRW5ITVJ?
JVM-2 M{Lhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2noSWlEPTB;MkeuOlYzOiEQvF2= MV3TRW5ITVJ?
UACC-257 NFPIZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLLTWM2OD1{Nz62PFc5KM7:TR?= MXXTRW5ITVJ?
SW1783 M4PGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXZV2JKSzVyPUK3Mlc4QDNizszN NGrwe3RUSU6JRWK=
HT-3 M4faVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ixd2lEPTB;MkiuNlE3PiEQvF2= M2K3WXNCVkeHUh?=
RL NFLhfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HlPGlEPTB;MkiuOVkyOSEQvF2= MXnTRW5ITVJ?
TK10 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv5NplKSzVyPUK4MlY2OzVizszN Mn;uV2FPT0WU
HT55 NGGz[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TuVGlEPTB;MkmuNFU3PSEQvF2= M1;0eXNCVkeHUh?=
BT-20 NF7HelFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJ7LkC1PFYh|ryP M2rkenNCVkeHUh?=
TGBC24TKB Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXVb|JKSzVyPUK5MlE5OzFizszN MnXDV2FPT0WU
HSC-2 NIPxbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXGTWM2OD1{OT6zNFAyKM7:TR?= MoDtV2FPT0WU
COLO-205 M{LNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfEXpBKSzVyPUK5MlM6PDRizszN NIm5UGtUSU6JRWK=
GT3TKB Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe3PYdEUUN3ME2yPU43QDd5IN88US=> MYfTRW5ITVJ?
T47D M33hZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7qdW1KSzVyPUK5Mlg2QDJizszN M1y2XnNCVkeHUh?=
OMC-1 MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLNUnJKSzVyPUOwMlE6OTlizszN MWrTRW5ITVJ?
PFSK-1 NGe0W4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;ETWM2OD1|MT6yOlU6KM7:TR?= MYrTRW5ITVJ?
JEG-3 M2rLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTrRWFKSzVyPUOxMlM2PjFizszN MUXTRW5ITVJ?
RD MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jY[WlEPTB;M{GuOVEyPSEQvF2= NFfvOlJUSU6JRWK=
NCI-H64 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq1TWM2OD1|Mj60NVc6KM7:TR?= NVfIbGZlW0GQR1XS
DMS-114 NVzib3d[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnPV3hpUUN3ME2zNk41OTh{IN88US=> NYjTOHQ1W0GQR1XS
NCI-H661 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf1fVltUUN3ME2zNk43PTBzIN88US=> NIG2dnFUSU6JRWK=
CAL-148 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLKdFRKSzVyPUOyMlY3PjVizszN NVn1VIpHW0GQR1XS
HuP-T3 NUL0WIlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXuc|lKSzVyPUOyMlk{OzhizszN NFvtV3BUSU6JRWK=
ES4 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV62Nm14UUN3ME2zN{4yPzB3IN88US=> NYS4Wmg{W0GQR1XS
Ca9-22 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPtNoJwUUN3ME2zN{41PjBzIN88US=> MX;TRW5ITVJ?
LP-1 NVv6PZhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzCR5RUUUN3ME2zOE4xQSEQvF2= NUf3RmhjW0GQR1XS
AU565 M{fhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDsNXlYUUN3ME2zOE42ODZ7IN88US=> MWfTRW5ITVJ?
MDA-MB-453 NIf4flJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LJSGlEPTB;M{WuNVQzPiEQvF2= MlfJV2FPT0WU
SNU-C1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jvNmlEPTB;M{WuNVcyKM7:TR?= NYTDXlJqW0GQR1XS
SW13 NH3i[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jQbGlEPTB;M{WuOFA4PiEQvF2= NH\NdIdUSU6JRWK=
NCI-H2122 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj6TWM2OD1|NT61OVk5KM7:TR?= NF7QR5JUSU6JRWK=
NCI-H1395 NEnH[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTN3Lk[2PVEh|ryP M1\K[HNCVkeHUh?=
J-RT3-T3-5 M1LrRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTMTWM2OD1|Nj6wNlk1KM7:TR?= M3q4dXNCVkeHUh?=
COR-L279 M1TGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXwUWJKSzVyPUO2MlE6QDFizszN MnrRV2FPT0WU
ATN-1 M{jheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj3XZJKSzVyPUO2Mlg2OTZizszN NYnlSIpTW0GQR1XS
HCC2998 M3XXTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTETWM2OD1|Nj64OVcyKM7:TR?= NF\0O|dUSU6JRWK=
UM-UC-3 NXTDTFZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfXcId2UUN3ME2zOk45Pjd3IN88US=> MkHGV2FPT0WU
DV-90 Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHOZVVKSzVyPUO2MlkxPjdizszN M2H3eXNCVkeHUh?=
ES8 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLHTWM2OD1|Nj65N|E5KM7:TR?= MWXTRW5ITVJ?
YAPC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN4Lkm2OVQh|ryP NFjxOnRUSU6JRWK=
HCC1599 NW\LdpRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPGTIZxUUN3ME2zO{4yPjF6IN88US=> MVfTRW5ITVJ?
UMC-11 NF\RdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X1V2lEPTB;M{euNlUxOyEQvF2= NV7n[5h7W0GQR1XS
THP-1 NV;CcnFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzkTGhKSzVyPUO3MlI5PjhizszN NH2yOXlUSU6JRWK=
OCUB-M M2PUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX2TWM2OD1|Nz6yPFkyKM7:TR?= NX[3UnNJW0GQR1XS
NCI-H1693 M3;zWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHOcZZKSzVyPUO3MlMzOzNizszN MUHTRW5ITVJ?
NCI-H345 NWLEXFdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLW[ZhKSzVyPUO3MlM3OjRizszN NYfBZ4o{W0GQR1XS
COLO-800 MnS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\BTWM2OD1|Nz61Olch|ryP M{\jT3NCVkeHUh?=
COLO-320-HSR MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInsdHNKSzVyPUO4MlM1QTJizszN NXzXWWdWW0GQR1XS
NCI-H596 NFfs[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjxboxEUUN3ME2zPE41PDh7IN88US=> M3LKZ3NCVkeHUh?=
NCI-H187 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;6VIhZUUN3ME2zPE44OzR2IN88US=> MWXTRW5ITVJ?
ECC4 NFXwbJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HXTmlEPTB;M{muNFgyPCEQvF2= MWfTRW5ITVJ?
KP-4 NVO2WJg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm3[mJGUUN3ME2zPU4yOjN3IN88US=> M{Dm[XNCVkeHUh?=
NCI-H2227 NXjYXIlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN7LkO5OFkh|ryP MmjDV2FPT0WU
22RV1 Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfFPZpbUUN3ME2zPU45Ozl6IN88US=> NIOx[GxUSU6JRWK=
SAS MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTRyLkC5OkDPxE1? NHu2dIVUSU6JRWK=
PANC-10-05 M3O3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37tUWlEPTB;NECuNVgzQCEQvF2= Ml3CV2FPT0WU
MDA-MB-468 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTRyLkWzOFYh|ryP M{\tWnNCVkeHUh?=
RPMI-7951 M4HjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XmS2lEPTB;NEGuNlA4PSEQvF2= M3jxeXNCVkeHUh?=
BB49-HNC Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILPNIJKSzVyPUSxMlIyPzlizszN M1rJUHNCVkeHUh?=
23132-87 NHO3UpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrNOGdKSzVyPUSxMlI4OzJizszN M3\JSnNCVkeHUh?=
HCC1569 M1jaTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLnTWM2OD12MT6yPFg2KM7:TR?= NXTIVpk3W0GQR1XS
CP66-MEL NUXSfFhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjJTWM2OD12Mj6xPFg3KM7:TR?= NFiwSnhUSU6JRWK=
K-562 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jwdGlEPTB;NEKuNlg2PCEQvF2= MY\TRW5ITVJ?
OCI-AML2 MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;5ZWlEPTB;NEKuPFk4PCEQvF2= MoDUV2FPT0WU
SW756 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TNNWlEPTB;NEOuNFM5QCEQvF2= MlS4V2FPT0WU
M14 M{m1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLHTWM2OD12Mz6zNVg6KM7:TR?= MUnTRW5ITVJ?
NCI-H1623 NVnScWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR|LkS2OEDPxE1? MXHTRW5ITVJ?
KNS-81-FD NH;GNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTR|Lke2NkDPxE1? M4TqWXNCVkeHUh?=
TGBC1TKB NXzuVo5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1WwZmlEPTB;NEOuPVA6QSEQvF2= Mn\DV2FPT0WU
RERF-LC-MS NYHadIJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS5d2hwUUN3ME20N{46OjhzIN88US=> NV7WXox4W0GQR1XS
PC-3 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLRTWM2OD12ND60N|Q4KM7:TR?= NX\xeZVVW0GQR1XS
HuP-T4 M2j5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjWcGxKSzVyPUS0MlQ1PzRizszN NGrSdo9USU6JRWK=
NCI-H510A NYnsSFRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzoTWM2OD12ND63NFgh|ryP NVjwUm1XW0GQR1XS
LB2518-MEL M3K2[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfrT5hrUUN3ME20OE44QTN5IN88US=> MnPDV2FPT0WU
TE-5 MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTyTWM2OD12NT65OVgyKM7:TR?= Mn:zV2FPT0WU
EW-24 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjBfldUUUN3ME20Ok4yPzJ|IN88US=> NVPvblJlW0GQR1XS
LB647-SCLC NVThTZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjKVottUUN3ME20Ok4zOTV3IN88US=> NVvHXnVqW0GQR1XS
NCI-H524 NIHHeW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX61WJR4UUN3ME20Ok44OTh3IN88US=> MljaV2FPT0WU
EW-11 M2LxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonLTWM2OD12Nj65N|c{KM7:TR?= MVnTRW5ITVJ?
KALS-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\IbmlEPTB;NEeuNlA3PiEQvF2= M4\JbXNCVkeHUh?=
BT-474 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfqTWM2OD12Nz60NlE3KM7:TR?= MkGzV2FPT0WU
SK-N-AS M4q3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTR5Lki4PEDPxE1? NH\kPWFUSU6JRWK=
HCC2157 NIjieodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDwdFA4UUN3ME20PE4xPzZizszN MoXGV2FPT0WU
HCC1954 NI[y[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR6LkG3NFQh|ryP NEG0fVRUSU6JRWK=
FADU NXq4[21uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LObWlEPTB;NEiuN|A{OSEQvF2= Mk\VV2FPT0WU
S-117 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rTcmlEPTB;NEiuN|gyPSEQvF2= NHr5R4FUSU6JRWK=
LS-1034 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTR6LkewOlch|ryP NI\BVYtUSU6JRWK=
CAMA-1 M3LZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR7LkW1OFMh|ryP NF72Z|ZUSU6JRWK=
LU-134-A NG\2[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ezdGlEPTB;NEmuPFA5PSEQvF2= MULTRW5ITVJ?
NCI-H1838 M3;yXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITnXJlKSzVyPUS5MlgxQDdizszN Ml24V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID