Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Cited by 65 Publications

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NETTN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvocFRKSzVyPUCuNFAxODByMEO1PUDPxE1? NWXI[YxoW0GQR1XS
MV-4-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3ZTWM2OD1yLkCwNFA6PTZizszN MXnTRW5ITVJ?
MEG-01 NYPCXXFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX4TWM2OD1yLkCwNFEzQCEQvF2= MYHTRW5ITVJ?
LAMA-84 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW1TWM2OD1yLkCwNFE3PSEQvF2= NYnieZM6W0GQR1XS
CGTH-W-1 NF;ZSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGwN4NGUUN3ME2wMlAxOTZ7IN88US=> Ml\HV2FPT0WU
KASUMI-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CwTWlEPTB;MD6wNFIyPyEQvF2= NH3wcYFUSU6JRWK=
BE-13 MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjPTWM2OD1yLkCwNlU6KM7:TR?= MXvTRW5ITVJ?
CTV-1 NX;TdotHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj3UGZ7UUN3ME2wMlAxPTJzIN88US=> M{j5cnNCVkeHUh?=
NKM-1 M4n3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEC2OVUh|ryP NGTEfHRUSU6JRWK=
MONO-MAC-6 M2fkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEC4N|ch|ryP NGLwSlBUSU6JRWK=
A204 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm2TWM2OD1yLkCxNlE5KM7:TR?= NIL5WGxUSU6JRWK=
GDM-1 M2rtNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEG4N|Mh|ryP M2Ox[3NCVkeHUh?=
AN3-CA MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDkTWM2OD1yLkCxPFc{KM7:TR?= NHf0S2tUSU6JRWK=
BL-70 NUHQOVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIezc|NKSzVyPUCuNFIyQTlizszN NXO1V3FbW0GQR1XS
Daudi MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fWfGlEPTB;MD6wNlU{PyEQvF2= M{XyVXNCVkeHUh?=
KU812 NEi3[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLBTWM2OD1yLkCyPFQ5KM7:TR?= MXfTRW5ITVJ?
KG-1 M2i2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPSTWM2OD1yLkCzNlk1KM7:TR?= NUjqdnNNW0GQR1XS
DOHH-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMES4NFMh|ryP MWLTRW5ITVJ?
HuO9 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEW0OFgh|ryP M2ftR3NCVkeHUh?=
EB2 NYWwcoR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LjZWlEPTB;MD6wOVU4PiEQvF2= NInhR3dUSU6JRWK=
G-402 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT2VIJKSzVyPUCuNFY{PDFizszN NYrySohjW0GQR1XS
SU-DHL-1 MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LoWmlEPTB;MD6wOlM4QSEQvF2= NYCzRWtmW0GQR1XS
NCI-H719 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\ZTWM2OD1yLkC3PFg5KM7:TR?= NV3seJV[W0GQR1XS
MLMA NGTiT2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3uTWM2OD1yLkC5NFYh|ryP NIfBdo1USU6JRWK=
KM12 MljrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;JUIdKSzVyPUCuNFk4OzdizszN M2e4bXNCVkeHUh?=
SUP-T1 Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfncGlKSzVyPUCuNFk6QDJizszN NVnBd3F{W0GQR1XS
MZ1-PC NUnrZ4Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn0OIdKSzVyPUCuNVE{OzZizszN MmjCV2FPT0WU
MFE-296 NWH5R4tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzsTWM2OD1yLkGxPFM6KM7:TR?= NUG3VFhOW0GQR1XS
ALL-PO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTiVYRoUUN3ME2wMlEzPDR|IN88US=> NVzMbHloW0GQR1XS
GB-1 M3juUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\1UWlEPTB;MD6xNlUyOiEQvF2= NInoOJZUSU6JRWK=
SIG-M5 NXjROJB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXn[np7UUN3ME2wMlE{OzdizszN Mn3SV2FPT0WU
P30-OHK MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37hVmlEPTB;MD6xOVY4OiEQvF2= NEDteFlUSU6JRWK=
NCI-H716 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPiTWM2OD1yLkG2NlY3KM7:TR?= NFPK[YxUSU6JRWK=
MPP-89 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\nbpdxUUN3ME2wMlE3QTN|IN88US=> MWPTRW5ITVJ?
SF126 M3LxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH1T417UUN3ME2wMlE4ODZ|IN88US=> M3\JRnNCVkeHUh?=
CTB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmW1TWM2OD1yLkG3N|E3KM7:TR?= MYrTRW5ITVJ?
CA46 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXn2[HcyUUN3ME2wMlE4PDh7IN88US=> MmLZV2FPT0WU
NCI-H520 NH;LVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMUe3N|Ih|ryP MkjyV2FPT0WU
CAL-85-1 NV3KUYZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonNTWM2OD1yLkG3PVI4KM7:TR?= NXj0PINkW0GQR1XS
NCI-H2342 NVvMPWZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPzTWM2OD1yLkG4OVc4KM7:TR?= MUHTRW5ITVJ?
697 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PoPWlEPTB;MD6xPFg4OSEQvF2= MVLTRW5ITVJ?
NY MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHhTWM2OD1yLkG5Nlg4KM7:TR?= MlzFV2FPT0WU
T98G M1PUWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:1Sm85UUN3ME2wMlE6OzF6IN88US=> MWTTRW5ITVJ?
NCI-H1703 NGnNUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMUm2NVUh|ryP MlvlV2FPT0WU
NCI-H2087 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3roN2lEPTB;MD6yNFQ{QSEQvF2= MlzZV2FPT0WU
PF-382 M1XObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknlTWM2OD1yLkKwPFc{KM7:TR?= M{HS[XNCVkeHUh?=
HCT-116 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;lVWlEPTB;MD6yNVA3QSEQvF2= NYG5OlhZW0GQR1XS
CAKI-1 M{PjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHuTWM2OD1yLkKxOlY3KM7:TR?= NUXFUlQ6W0GQR1XS
CCF-STTG1 M1HXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMkK0O|Uh|ryP MoPQV2FPT0WU
D-392MG M4HWVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLCZ|RKSzVyPUCuNlMyPzdizszN NYGwN2RVW0GQR1XS
RT-112 M3PXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjUV29KSzVyPUCuNlM4QTVizszN MkO1V2FPT0WU
MES-SA MnXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PYXGlEPTB;MD6yOFE5PyEQvF2= NWXuRVF[W0GQR1XS
LC-2-ad Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Ho[WlEPTB;MD6yOFI3PSEQvF2= NFjHSFdUSU6JRWK=
NOS-1 M1nPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPVV4JiUUN3ME2wMlI1OzZ5IN88US=> NVjNdWVuW0GQR1XS
NALM-6 NFXscohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33UWmlEPTB;MD6yOVU1OyEQvF2= NX;QOmo6W0GQR1XS
TE-15 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnt[Fd1UUN3ME2wMlI3ODlzIN88US=> M1W4VnNCVkeHUh?=
786-0 NF:y[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMk[yNlgh|ryP MkXuV2FPT0WU
IST-MES1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;jW20{UUN3ME2wMlI3QDJ7IN88US=> NELmdlJUSU6JRWK=
KYSE-180 MkO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPRSnAzUUN3ME2wMlI3QDlzIN88US=> NYTBOIczW0GQR1XS
YT NVeyPWhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;lN2NzUUN3ME2wMlI3QTd2IN88US=> NFXMWWxUSU6JRWK=
A427 NEPvNGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PobGlEPTB;MD6yO|I3PCEQvF2= NV25TJlSW0GQR1XS
KYSE-450 NIXT[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DnXGlEPTB;MD6yO|MzQSEQvF2= MlHaV2FPT0WU
HuH-7 NIT6bG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTTOYJVUUN3ME2wMlI4PzZ|IN88US=> M4\PbHNCVkeHUh?=
CAS-1 MkPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMkizNFMh|ryP M{DvbXNCVkeHUh?=
KURAMOCHI NIL4SmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjhN4FwUUN3ME2wMlI5PDF7IN88US=> MY\TRW5ITVJ?
ACHN NES4W25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTxOGxKSzVyPUCuNlk{OjNizszN MY\TRW5ITVJ?
HGC-27 NF64WWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjvRWxpUUN3ME2wMlI6OzV|IN88US=> NXTMW4plW0GQR1XS
A172 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV25UG9mUUN3ME2wMlI6PTd5IN88US=> NYO4b5VDW0GQR1XS
SNU-449 NF7pZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\nWWlEPTB;MD6yPVk3PCEQvF2= NV31NIF1W0GQR1XS
SW982 NV[3ZWZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;EO2lEPTB;MD6yPVk4QCEQvF2= MX;TRW5ITVJ?
EFO-21 NV3COXZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTvTWM2OD1yLkOwOFEyKM7:TR?= NF\4fYNUSU6JRWK=
NCI-H2030 NHvmTYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXCN5BTUUN3ME2wMlMyOTZ2IN88US=> NHy0eI9USU6JRWK=
HT-144 NH;x[llIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OyVmlEPTB;MD6zNVI5KM7:TR?= M{LxW3NCVkeHUh?=
MFE-280 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW2TIhKSzVyPUCuN|E1PTNizszN NWKxUFlXW0GQR1XS
SK-LU-1 NIXoOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfYNIhWUUN3ME2wMlMyPDZ4IN88US=> NU\YTFRtW0GQR1XS
NCI-H2052 MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPqTWM2OD1yLkOxOFg1KM7:TR?= NHHCcWdUSU6JRWK=
SK-HEP-1 M1S2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnqTWM2OD1yLkOzN|Y5KM7:TR?= MnnxV2FPT0WU
QIMR-WIL NH7UVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DBe2lEPTB;MD6zN|QzPCEQvF2= MYnTRW5ITVJ?
A2780 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTubFNKSzVyPUCuN|Q{ODRizszN Mn7KV2FPT0WU
ACN Mnn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwM{S4O|Mh|ryP M4HJOnNCVkeHUh?=
BxPC-3 M4\C[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvVVFF{UUN3ME2wMlM1QTh7IN88US=> M32xNnNCVkeHUh?=
BCPAP MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHJTWM2OD1yLkO2NFAyKM7:TR?= NEjKNpBUSU6JRWK=
HOP-62 NFvFc|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLPfGF7UUN3ME2wMlM3OTB4IN88US=> MVTTRW5ITVJ?
SW1710 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwM{[0OVUh|ryP NVqzU2l1W0GQR1XS
OPM-2 NFT5fmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3zVpFKSzVyPUCuN|Y1PzNizszN MkfaV2FPT0WU
DBTRG-05MG M3nMZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7JfHh2UUN3ME2wMlM5ODV2IN88US=> NELMUohUSU6JRWK=
SK-MEL-24 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXHZ5lZUUN3ME2wMlM6PzlzIN88US=> MlPFV2FPT0WU
8305C M{\a[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP3UIlvUUN3ME2wMlM6Pzl|IN88US=> MU\TRW5ITVJ?
OVCAR-4 NH\hfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNEG1PFYh|ryP M1\xVnNCVkeHUh?=
HLE MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;4TWM2OD1yLkSxPFYh|ryP NFzqWYtUSU6JRWK=
NCI-H747 NWfvSWR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzKXllKSzVyPUCuOFIyOzdizszN NXTTO2RHW0GQR1XS
SW780 NG\zc|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrFTWM2OD1yLkSyN|Q3KM7:TR?= MVPTRW5ITVJ?
KYSE-150 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\CTWM2OD1yLkSyOFE2KM7:TR?= M4[3bXNCVkeHUh?=
H4 MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7nOmpJUUN3ME2wMlQzPDVzIN88US=> Mm\NV2FPT0WU
SW1088 NXLUOFF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr1TWM2OD1yLkS0N|kh|ryP M4fUUnNCVkeHUh?=
SF268 MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTYTWM2OD1yLkS0PFYh|ryP MkXHV2FPT0WU
RT4 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfFTWM2OD1yLkS1NVEyKM7:TR?= NV;WfJhYW0GQR1XS
NCI-H522 M2ryWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HsemlEPTB;MD60OVI4KM7:TR?= NHS1N49USU6JRWK=
LCLC-97TM1 NG\HfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jCT2lEPTB;MD60OlE6PSEQvF2= NVnERmxTW0GQR1XS
CAL-39 NW\4d|dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDLPVhKSzVyPUCuOFY2OTlizszN MXPTRW5ITVJ?
CAL-120 M3;VZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\UTWM2OD1yLkS3OlQ{KM7:TR?= NHX3SI5USU6JRWK=
ESS-1 M17ydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwNEe4NlEh|ryP MoWyV2FPT0WU
KARPAS-45 NYC1bZFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzHcItKSzVyPUCuOFg6OzNizszN NX;YUnZrW0GQR1XS
DU-4475 M2PXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nOTWlEPTB;MD60PVUyOSEQvF2= NWDvdWxiW0GQR1XS
VMRC-RCZ MlXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP4TWM2OD1yLkS5PVA1KM7:TR?= Ml7vV2FPT0WU
HOS MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwNUCzOlUh|ryP NVX3T293W0GQR1XS
MOLT-16 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwNUG4NFgh|ryP MVzTRW5ITVJ?
RPMI-6666 NFvLe4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{THPGlEPTB;MD61NlE{PSEQvF2= MknLV2FPT0WU
K052 MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXvTW9KSzVyPUCuOVIyPCEQvF2= NWj2WWlYW0GQR1XS
EHEB NHHNd2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjxN285UUN3ME2wMlUzOTh{IN88US=> NIHpVlVUSU6JRWK=
MFH-ino NXS4dodHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XzTmlEPTB;MD61NlM2OSEQvF2= NFL4WnpUSU6JRWK=
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A673 NFrNRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwOUe1NVYh|ryP Mlj1V2FPT0WU
L-428 NUS2PYczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjUdpFKSzVyPUGuPVkyPzlizszN MULTRW5ITVJ?
KM-H2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJwMEGwPUDPxE1? NVj6U|NCW0GQR1XS
MC-IXC MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwMEKyO|Mh|ryP NHfrb2ZUSU6JRWK=
COLO-678 MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:1W2lEPTB;Mj6wOFIxPyEQvF2= MX\TRW5ITVJ?
MEL-JUSO MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HLOmlEPTB;Mj6wO|g2OSEQvF2= MYPTRW5ITVJ?
HCC38 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwMEi0N|Mh|ryP NYW0SVQ5W0GQR1XS
UACC-62 NUTrNIlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[0UGlEPTB;Mj6wPFg2PSEQvF2= MnfsV2FPT0WU
OAW-42 NFTZT2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwMEm3NVEh|ryP NVzWXWc{W0GQR1XS
LB996-RCC NI\GcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[5Spd3UUN3ME2yMlE{QDF5IN88US=> M4jnWnNCVkeHUh?=
COR-L105 NVXCeJg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn6UFZ7UUN3ME2yMlE3Ozd|IN88US=> MXzTRW5ITVJ?
RCC10RGB NXXXSXhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnWTWM2OD1{LkG4OVc3KM7:TR?= NEjxbZVUSU6JRWK=
A431 M4Owcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTCSW1sUUN3ME2yMlE6ODF7IN88US=> NVrBbIZFW0GQR1XS
NCI-H292 NHTCO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJwMkO5OVEh|ryP NEfkTJZUSU6JRWK=
SK-UT-1 NEPwVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7YXXRWUUN3ME2yMlM{OTh2IN88US=> MljNV2FPT0WU
PANC-08-13 M{Pld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rodWlEPTB;Mj6zN|I{PSEQvF2= M3LSUXNCVkeHUh?=
ST486 M4Tybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTGTWM2OD1{LkSxNFQ5KM7:TR?= NVHOW5U2W0GQR1XS
SJSA-1 Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvNVIVyUUN3ME2yMlQyOjdzIN88US=> MmrzV2FPT0WU
RKO MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zFXWlEPTB;Mj60NlAzQSEQvF2= NX:4dXJIW0GQR1XS
NCI-H1793 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj3TWM2OD1{LkS0NFI6KM7:TR?= M{jZfHNCVkeHUh?=
639-V NGHBVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPWUlNKSzVyPUKuOFU{QDJizszN M1\ZW3NCVkeHUh?=
ES3 NX;DdGpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rUN2lEPTB;Mj60PVc{PyEQvF2= NXPmS5h5W0GQR1XS
NCI-H1792 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3l[5liUUN3ME2yMlU3QDJ4IN88US=> MX\TRW5ITVJ?
NCI-H1651 M1HGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLaTWM2OD1{LkW4NlEh|ryP NV63bm5jW0GQR1XS
SN12C Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwNUi0PFch|ryP NU[z[5JwW0GQR1XS
COLO-679 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzVTWM2OD1{LkW4OlA2KM7:TR?= NFnzZpZUSU6JRWK=
U-118-MG M4LT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnMXpFuUUN3ME2yMlU5QDd{IN88US=> NXLvfYFMW0GQR1XS
Ramos-2G6-4C10 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe5NIhKSzVyPUKuOlQ5ODdizszN Mlj4V2FPT0WU
HCT-15 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwNki3PVIh|ryP MlnwV2FPT0WU
MDA-MB-157 NYrNdI5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLLW|RuUUN3ME2yMlcxPzR5IN88US=> NULsVmk1W0GQR1XS
K5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXCTWM2OD1{LkexPFQ2KM7:TR?= NEjv[mVUSU6JRWK=
MKN45 NH7UfoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknuTWM2OD1{LkezN|Y3KM7:TR?= NWLKVIFWW0GQR1XS
DMS-273 Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJwN{W2N|Ih|ryP NUPqc2IxW0GQR1XS
C8166 M2PQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYna[GRIUUN3ME2yMlc5PTF|IN88US=> M2TldHNCVkeHUh?=
Calu-3 M32w[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrpTWM2OD1{Lke4PVY6KM7:TR?= MX;TRW5ITVJ?
SNB75 NVTybZplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;ZNlRKSzVyPUKuPFg2OzVizszN MojRV2FPT0WU
BFTC-905 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGydYpKSzVyPUKuPVAyQTFizszN NWnWfIJjW0GQR1XS
C-4-II NVq1cJdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuybXRyUUN3ME2yMlkyOzV|IN88US=> MkfpV2FPT0WU
MS-1 NGP6d41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLXXWlKSzVyPUKuPVY4PjlizszN NGG5VWxUSU6JRWK=
A375 NVf2U3V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PDfGlEPTB;Mz6wPFE5PCEQvF2= NV:yS|ZXW0GQR1XS
KYSE-70 NV7BTpBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTNwMEi4PFIh|ryP NUjpUmRSW0GQR1XS
KYSE-510 NX3E[nVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwMUC5PVUh|ryP MmHxV2FPT0WU
LN-405 NVywblFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nSdmlEPTB;Mz6xN|UyQCEQvF2= NYW1TJpjW0GQR1XS
BOKU M3qwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPNTWM2OD1|LkG0NlU3KM7:TR?= NIXJOJFUSU6JRWK=
TE-10 NV;UdppsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL3co9QUUN3ME2zMlE4OzZ{IN88US=> MV;TRW5ITVJ?
MKN1 M{TGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnixTWM2OD1|LkG4OFg{KM7:TR?= MmLJV2FPT0WU
M059J NHzJXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LIdmlEPTB;Mz6yNFE4OyEQvF2= M2TPSnNCVkeHUh?=
GOTO NWLy[VJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnCTWM2OD1|LkKyNFM6KM7:TR?= M3rU[XNCVkeHUh?=
DK-MG Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\SR|JYUUN3ME2zMlI2QTd4IN88US=> MlS3V2FPT0WU
NCI-H727 NUDzdWZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvxcndKSzVyPUOuNlY2QCEQvF2= NF7vNGVUSU6JRWK=
NB12 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnHZnFYUUN3ME2zMlM{OjJ2IN88US=> NF\OOnJUSU6JRWK=
DOK NHvZSYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzPVJMzUUN3ME2zMlM3OTh4IN88US=> M1LXeHNCVkeHUh?=
KYSE-410 NUTNV4d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNwM{[yPFch|ryP NILYVGtUSU6JRWK=
AM-38 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LXWGlEPTB;Mz6zPFA2OSEQvF2= NH7vN3VUSU6JRWK=
GR-ST MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTNwNEW3N|Ih|ryP MWTTRW5ITVJ?
D-247MG M2rZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\oTGJKSzVyPUOuOFgzPjNizszN MWPTRW5ITVJ?
TE-8 NULyOJZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\VTWM2OD1|LkS5N|M{KM7:TR?= MXrTRW5ITVJ?
LS-411N NGjQS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2n0UWlEPTB;Mz60PVY6OiEQvF2= Ml3pV2FPT0WU
SK-MES-1 M4PUZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNwNU[0N|Mh|ryP M3npUnNCVkeHUh?=
SF295 NGi0TpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLXTWM2OD1|Lk[xOVUzKM7:TR?= MYnTRW5ITVJ?
SK-MEL-30 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTNwNkW5NlEh|ryP NEfiU5dUSU6JRWK=
LB2241-RCC Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;1c3NKSzVyPUOuOlYzPiEQvF2= MYnTRW5ITVJ?
PC-14 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLRTWM2OD1|Lk[2OFM4KM7:TR?= Moj0V2FPT0WU
EW-7 M3rOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUUVRIUUN3ME2zMlY4Pjl|IN88US=> NY\SRXlTW0GQR1XS
NMC-G1 NXLGcY5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLITWM2OD1|LkexPFM4KM7:TR?= MmTJV2FPT0WU
TE-441-T NGHaS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PZVGlEPTB;Mz63N|AzQCEQvF2= NUjVUnhnW0GQR1XS
NCI-H1618 M{H2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[0TWM2OD1|LkixPFc2KM7:TR?= NY\iNYo2W0GQR1XS
PANC-03-27 NEO4cWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\JT2lEPTB;Mz64NVkyPiEQvF2= M3Xn[XNCVkeHUh?=
NCI-H2228 M3PXUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofETWM2OD1|LkizNVI3KM7:TR?= MkO4V2FPT0WU
CAPAN-1 M3TyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P6eGlEPTB;Mz64O|AxQSEQvF2= MV7TRW5ITVJ?
KLE MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjqfpVFUUN3ME2zMlkxPjdizszN M3z4bHNCVkeHUh?=
Becker M1HLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTNwOUK4OFkh|ryP MlfNV2FPT0WU
SK-PN-DW MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3XVWRVUUN3ME20MlA4QTd2IN88US=> NXTONYNEW0GQR1XS
Hs-578-T MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXeyRllCUUN3ME20MlA5OzB4IN88US=> MVzTRW5ITVJ?
RS4-11 M{DIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHnTWM2OD12LkGxNlU2KM7:TR?= MWTTRW5ITVJ?
D-502MG NXnrN|R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPESo81UUN3ME20MlE3QTl5IN88US=> MoTCV2FPT0WU
GI-1 M2jTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37aSGlEPTB;ND6yPFI6QSEQvF2= MXvTRW5ITVJ?
NCI-H209 NFLkeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLpTWM2OD12LkOzO|gh|ryP M1\XNnNCVkeHUh?=
SK-OV-3 NHXGNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTSXVI1UUN3ME20MlQ5OTR7IN88US=> NE\WNGVUSU6JRWK=
LOUCY M1znPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnewTWM2OD12LkS4OFMzKM7:TR?= NF2yZnlUSU6JRWK=
NCI-H69 NIe0SnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fJdmlEPTB;ND61NVc6OyEQvF2= M1y4OnNCVkeHUh?=
SCC-9 NHPzXINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTXV3VKSzVyPUSuOVMyPzJizszN MYjTRW5ITVJ?
NCI-H526 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnQTWM2OD12LkW5Nlk{KM7:TR?= Mnr3V2FPT0WU
NCI-H2170 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfVTWM2OD12Lk[2O|cyKM7:TR?= M1TnbHNCVkeHUh?=
SR NUHiSoo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRwN{CwOFgh|ryP MnXMV2FPT0WU
CMK NYnuWHRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH64b2FKSzVyPUSuO|IyODFizszN MXLTRW5ITVJ?
COLO-829 NFLNSWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7jTWM2OD12Lke3NFQ{KM7:TR?= Ml\0V2FPT0WU
HuO-3N1 MkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTRwOEOyPFEh|ryP Mnq0V2FPT0WU
5637 NYTzfFU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnuOFdKSzVyPUSuPVA1QDdizszN Mom4V2FPT0WU
A253 NGrjb|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vE[mlEPTB;ND65O|cxQCEQvF2= MXHTRW5ITVJ?
NB10 NV3mfJFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP6TWM2OD13LkC3OFk4KM7:TR?= NYn3NnFDW0GQR1XS
SF539 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHtTWM2OD13LkC5PVU6KM7:TR?= NVLZfY43W0GQR1XS
HAL-01 MlLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTVwMUS2OFUh|ryP MlzUV2FPT0WU
MHH-ES-1 NUHQWFVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvBZoZKSzVyPUWuNVY6OjVizszN MoHEV2FPT0WU
DEL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLYOpZKSzVyPUWuNlc2QDJizszN NHXKeXRUSU6JRWK=
NCI-H1299 NWO5NFZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIS2UZRKSzVyPUWuN|UxODdizszN MX7TRW5ITVJ?
ChaGo-K-1 NGPte|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTVwM{WxNFch|ryP NH:zfGxUSU6JRWK=
HMV-II M2GxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnve3dKSzVyPUWuN|k1OyEQvF2= M1zrO3NCVkeHUh?=
NB69 NUTNTIJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mki5TWM2OD13LkO5OlMyKM7:TR?= M2jSVHNCVkeHUh?=
NCI-H1882 M3TyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;TSZFKSzVyPUWuOFM{PjRizszN NFjlb3VUSU6JRWK=
SNU-475 NIrUSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\qSWlEPTB;NT60O|E4OSEQvF2= NUHDU2pzW0GQR1XS
RXF393 M17xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT4TWM2OD13LkS4OFk1KM7:TR?= MmPLV2FPT0WU
CAL-51 M37tWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT5RYVWUUN3ME21MlYzQDV|IN88US=> NETuPFdUSU6JRWK=
SW1573 NVrmNJdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTVwNkO1N|Qh|ryP M1PrTHNCVkeHUh?=
GCT NHXJTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fsNmlEPTB;NT63OVkzQSEQvF2= MXHTRW5ITVJ?
COR-L88 MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jqXGlEPTB;NT63Olg1PiEQvF2= MmHFV2FPT0WU
MDA-MB-134-VI NUXhXVNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfzXJU2UUN3ME21Mlg4PTN4IN88US=> MlfnV2FPT0WU
NB5 NUXRblJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\EV4ZKSzVyPUWuPVI1PCEQvF2= NILTOnVUSU6JRWK=
GMS-10 NF7JVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnDe5pXUUN3ME21Mlk3QDZzIN88US=> NEfpWHBUSU6JRWK=
CHP-212 NH22UFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPjfIlKSzVyPU[uOFgzPjdizszN MYrTRW5ITVJ?
TE-11 Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2O0[2lEPTB;Nj61OVE5OiEQvF2= Ml;GV2FPT0WU
SW962 NXX1R2dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LQ[WlEPTB;Nj62OVc4PCEQvF2= MlfoV2FPT0WU
MZ2-MEL MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;yVXlKSzVyPU[uPFIxOTFizszN MnLZV2FPT0WU
C-33-A M{HITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvqSlhQUUN3ME22MlkyPjh6IN88US=> NYXlfmNDW0GQR1XS
IGR-1 NYSyW|dsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4SyTmlEPTB;Nj65O|gzPiEQvF2= NXvBdXdWW0GQR1XS
MOLT-4 M1zjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTdwMUW0NFYh|ryP M4Kxe3NCVkeHUh?=
NCI-H1650 M4rLUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nsUGlEPTB;Nz6yO|A1PiEQvF2= MoLGV2FPT0WU
AsPC-1 NGn4T4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTdwMki2NFUh|ryP MYnTRW5ITVJ?
SNU-C2B NG\FU5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTLeGhKSzVyPUeuNlk2PzFizszN MVHTRW5ITVJ?
MKN7 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTdwM{eyN|Uh|ryP NUjwOVhrW0GQR1XS
SW620 M{TST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoSxTWM2OD15LkO4NlA2KM7:TR?= NXLWbWtrW0GQR1XS
SK-MEL-28 NGTlbZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zJTGlEPTB;Nz60NFc6QCEQvF2= MkPRV2FPT0WU
TE-6 M1rIWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnxTWM2OD15LkS0PVA5KM7:TR?= M2XWe3NCVkeHUh?=
D-263MG Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHvbnRKSzVyPUeuOFU4PjJizszN MlrUV2FPT0WU
NCI-H1355 M37hVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\1TGlEPTB;Nz63O|AzQSEQvF2= NYW5cFROW0GQR1XS
DSH1 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\ITWM2OD15Lke5O|YzKM7:TR?= NXTqc4hDW0GQR1XS
NCI-H460 MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm1[|NKSzVyPUiuNFA3QTRizszN NHXqT5hUSU6JRWK=
NCI-H1563 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzoblNKSzVyPUiuNFc2ODhizszN NEHER5FUSU6JRWK=
SW948 NIC3N2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV22eVR1UUN3ME24MlExPzR2IN88US=> NVHacI9nW0GQR1XS
LK-2 NVP1OFJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRThwMUK4N|Mh|ryP MWfTRW5ITVJ?
HT-1080 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnhNllKSzVyPUiuNVMyPzVizszN NED3WVFUSU6JRWK=
NCI-H441 NFjGVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjrTWM2OD16LkG5N{DPxE1? NY[xeo8{W0GQR1XS
HSC-4 Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPGTWM2OD16LkK4O|Ih|ryP NFjJ[3JUSU6JRWK=
LXF-289 NYXUcIduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvTTWM2OD16LkO1PVQ{KM7:TR?= MXTTRW5ITVJ?
MRK-nu-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK4TWM2OD16LkO2N|A1KM7:TR?= NULQOHpoW0GQR1XS
no-11 NGPjS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjrTWM2OD16LkS3NVM{KM7:TR?= NWPpRZdqW0GQR1XS
SNU-387 Mm\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLLVnJKSzVyPUiuOlMzPDZizszN MnfNV2FPT0WU
Detroit562 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG3SZRKSzVyPUiuO|U1PTVizszN M1XpVnNCVkeHUh?=
SW954 M3P6Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHRTWM2OD16Lke2PFMzKM7:TR?= NHK3NGpUSU6JRWK=
P12-ICHIKAWA NHzv[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRThwN{i5OEDPxE1? MmTPV2FPT0WU
TE-9 M4rFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRThwOEGwOlIh|ryP NHnrVmlUSU6JRWK=
NB13 M4qyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XzR2lEPTB;OD64N|c6PiEQvF2= MUjTRW5ITVJ?
BPH-1 M2KySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRThwOEWwPFEh|ryP NFjJem1USU6JRWK=
KMOE-2 NG\OcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq5WGNwUUN3ME24Mlg4QDl{IN88US=> NYnqWINrW0GQR1XS
RPMI-8402 NH3MT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P5OmlEPTB;OD64PVkzPiEQvF2= MmXVV2FPT0WU
OVCAR-3 Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLGXIpUUUN3ME24Mlk4PzN{IN88US=> NXLiNZR7W0GQR1XS
NCI-H2196 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2yeGlKSzVyPUiuPVg3ODZizszN MWjTRW5ITVJ?
MZ7-mel M17iSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOwTYhWUUN3ME25MlA{PDZizszN MWfTRW5ITVJ?
GP5d MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;tTo1rUUN3ME25MlA3OzF|IN88US=> MUnTRW5ITVJ?
NCI-N87 M2HQUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DDUWlEPTB;OT60OFc{OSEQvF2= MVHTRW5ITVJ?
EW-16 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTlwNES4OFgh|ryP MoezV2FPT0WU
Calu-6 NYDrc2RDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTlwNEm3NFMh|ryP M1;PeXNCVkeHUh?=
LC4-1 M2m1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq3dFdCUUN3ME25MlYzPTdizszN NWHpPYdkW0GQR1XS
CCRF-CEM MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLSTWM2OD17Lk[4O|Y3KM7:TR?= M{XvUXNCVkeHUh?=
BC-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n5R2lEPTB;OT63PFk6KM7:TR?= MljKV2FPT0WU
NCI-SNU-16 NYH1TVE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLFcVZKSzVyPUmuO|k1QTVizszN NGTQc41USU6JRWK=
NCI-H28 M{\lb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rod2lEPTB;OT64OFk{OyEQvF2= MWfTRW5ITVJ?
SBC-1 M1\ueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nmRmlEPTB;MUCuNFczKM7:TR?= MVfTRW5ITVJ?
TUR MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOwTWM2OD1zMD6xOlU4KM7:TR?= NFmxXZBUSU6JRWK=
MDA-MB-231 NUG1PZNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTFyLkKxNVQh|ryP M{e5TnNCVkeHUh?=
C3A NGr5N|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLqTWM2OD1zMD6zNVc6KM7:TR?= NVzPbVFWW0GQR1XS
SW1990 NXvm[WFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\Eb45QUUN3ME2xNE4{OjhizszN MoW3V2FPT0WU
NCI-H1993 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP2emVKSzVyPUGwMlU3QTNizszN MX\TRW5ITVJ?
SK-CO-1 NF;ubnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS4VW9KSzVyPUGwMlc4PyEQvF2= NUfaNpFxW0GQR1XS
OAW-28 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvsc2xJUUN3ME2xNE46QDh6IN88US=> NWHQcmp3W0GQR1XS
HN NUHNcmxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W4SmlEPTB;MUGuNVE{OSEQvF2= MYTTRW5ITVJ?
NCI-H1304 NFT6boZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jubGlEPTB;MUGuNVU4PiEQvF2= NGq3[m5USU6JRWK=
Daoy NWjCZpAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULKOI5NUUN3ME2xNU41OzN4IN88US=> MVLTRW5ITVJ?
VA-ES-BJ NFvP[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFzLkexPVUh|ryP Mlu3V2FPT0WU
MCF7 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi2OXJLUUN3ME2xNU45OTJ4IN88US=> NYjkVXd7W0GQR1XS
VM-CUB-1 M2DQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTFzLkmwPVEh|ryP MnfKV2FPT0WU
IPC-298 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHGTWM2OD1zMT65N|g{KM7:TR?= NEDjSo1USU6JRWK=
NCI-H2126 M2PlTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HKWmlEPTB;MUKuNFIyQCEQvF2= NYXmTHBrW0GQR1XS
OVCAR-8 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnywTWM2OD1zMj6xNVQyKM7:TR?= MUPTRW5ITVJ?
SJRH30 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL5TWM2OD1zMj6yNlk6KM7:TR?= MUPTRW5ITVJ?
DMS-53 Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;RZ2NKSzVyPUGyMlI3PDlizszN MUPTRW5ITVJ?
NCI-H322M NGTqc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jIO2lEPTB;MUKuN|M2PyEQvF2= MknPV2FPT0WU
RVH-421 NVeycZYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r6VGlEPTB;MUKuOFkxPCEQvF2= M2fvWHNCVkeHUh?=
Raji MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnSSXBKSzVyPUGyMlYyPCEQvF2= MmrFV2FPT0WU
MDA-MB-415 NIn6cplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7yTWM2OD1zMj62OFQ1KM7:TR?= NEfFXGRUSU6JRWK=
EFE-184 NFzo[FhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;PeGlEPTB;MUKuO|ExPiEQvF2= NVvNXZhKW0GQR1XS
BFTC-909 NXrq[oJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjTOpIyUUN3ME2xNk46OjR5IN88US=> MXfTRW5ITVJ?
BHY MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn70TWM2OD1zMz6zN|kh|ryP Mn75V2FPT0WU
YKG-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLRTWM2OD1zMz6zO|Q6KM7:TR?= M1PGWnNCVkeHUh?=
EW-3 NVjBO25[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrzTWM2OD1zMz63NVY{KM7:TR?= Ml3iV2FPT0WU
HCC1143 M33UWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT1TWM2OD1zMz63OFM4KM7:TR?= Mn\tV2FPT0WU
REH MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF|Lki5PFIh|ryP NFfPcotUSU6JRWK=
CESS NHHMXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTF|Lkm0PFkh|ryP NFuwSpBUSU6JRWK=
EFM-19 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmntTWM2OD1zND6xNVEzKM7:TR?= NV\yeJdlW0GQR1XS
U031 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn72TWM2OD1zND60NFg2KM7:TR?= NVS4TGQxW0GQR1XS
ES1 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\ETYlKSzVyPUG0MlQ5PTFizszN NX3DPWh3W0GQR1XS
HSC-3 M3zkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF2Lk[yNVUh|ryP MUHTRW5ITVJ?
LOXIMVI M33rVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT3WHg6UUN3ME2xOE44ODZ6IN88US=> MVrTRW5ITVJ?
A388 NHjrTY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HiOGlEPTB;MUSuO|U2PiEQvF2= NXT4UpZrW0GQR1XS
KP-N-YS MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXiTWM2OD1zND63O|Mh|ryP NXy4UWN2W0GQR1XS
Capan-2 NFLzZmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n3OmlEPTB;MUSuO|g3KM7:TR?= MX7TRW5ITVJ?
SKG-IIIa NXS2bXZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnNXVdRUUN3ME2xOE45QDZ{IN88US=> M{nkVnNCVkeHUh?=
HEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELVUXRKSzVyPUG0Mlg6QTdizszN NH\vPG5USU6JRWK=
BEN M3LTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPBcYVsUUN3ME2xOE46PzZ4IN88US=> MYTTRW5ITVJ?
MC116 NVjqNmdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH3TWM2OD1zNT6xOVk6KM7:TR?= MmPVV2FPT0WU
IGROV-1 M{XJe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfJWphQUUN3ME2xOU4zOzF5IN88US=> NHPxZoxUSU6JRWK=
NCI-H1648 NWC1OlZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXwTWM2OD1zNT61N|A2KM7:TR?= M1TVT3NCVkeHUh?=
ABC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF3LkiwN|Mh|ryP Ml3RV2FPT0WU
EW-18 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj0R25KSzVyPUG1Mlk6PzlizszN NX\xbohyW0GQR1XS
BC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTF4LkC1OlIh|ryP NYT2[3RQW0GQR1XS
NCI-H1437 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF4LkC2Olch|ryP MoPNV2FPT0WU
SCC-15 Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fJfWlEPTB;MU[uNlgzPSEQvF2= MoHmV2FPT0WU
TT Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTF4LkW4PFgh|ryP Mm\zV2FPT0WU
KINGS-1 NUDpeGdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXOwNIRNUUN3ME2xOk45Ojd|IN88US=> NVuzSW1mW0GQR1XS
C32 NVK4[5UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF4Lkm3NVch|ryP NFjETnRUSU6JRWK=
SBC-5 MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF5LkG0O|kh|ryP M{PFOXNCVkeHUh?=
NB1 NFL0XZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe5UY1KSzVyPUG3MlMyQDhizszN Mmr3V2FPT0WU
EB-3 NFPHV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TkdWlEPTB;MUeuOVc3KM7:TR?= NGXzfW5USU6JRWK=
NCI-H748 NIrjPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX5W|hKSzVyPUG3MlcxOzVizszN NUXwdXY4W0GQR1XS
IST-SL1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz3TWM2OD1zNz63OVI3KM7:TR?= NYrS[4lzW0GQR1XS
WM-115 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13tcmlEPTB;MUeuPFA5PSEQvF2= NInmNo1USU6JRWK=
NCI-H226 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofkTWM2OD1zNz65OVQ3KM7:TR?= NHL3OFFUSU6JRWK=
CAL-33 NIrjOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPES5ZCUUN3ME2xPE4zPzhzIN88US=> NYrQeINCW0GQR1XS
SCC-4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTF6LkOyNlkh|ryP NYLFV2RJW0GQR1XS
RMG-I NI\YXGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LsOmlEPTB;MUiuOlk1PyEQvF2= MXTTRW5ITVJ?
KOSC-2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTZS3hKSzVyPUG4Mlc4PDZizszN MY\TRW5ITVJ?
A2058 NHjwW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{WzZWlEPTB;MUiuPFI2PSEQvF2= NEi1XXJUSU6JRWK=
HCC70 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLzTWM2OD1zOT6zPFk1KM7:TR?= M4PaUnNCVkeHUh?=
C2BBe1 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTF7LkSxOFgh|ryP NIrWfIpUSU6JRWK=
NCI-H650 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTF7LkW4PVkh|ryP MUfTRW5ITVJ?
CAL-72 NUO2SlN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnUTnhKSzVyPUG5MlY4OzdizszN M4rUd3NCVkeHUh?=
L-363 NF6yWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv1TWM2OD1{MD6wNlEzKM7:TR?= NGLBPFVUSU6JRWK=
SNU-423 M1riVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTJyLkGwOFMh|ryP Ml:xV2FPT0WU
PLC-PRF-5 NYnaVnJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fOS2lEPTB;MkCuN|kxPiEQvF2= M{LnWnNCVkeHUh?=
SW1463 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrZVIFxUUN3ME2yNE41PTJ3IN88US=> MWnTRW5ITVJ?
769-P M1f6Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrLTWM2OD1{MD62O|Y6KM7:TR?= M2DuSXNCVkeHUh?=
DMS-79 NH7vOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX2TWM2OD1{MD64OFkh|ryP M3z2bnNCVkeHUh?=
Saos-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJyLkm1OVYh|ryP NUD4ZZY{W0GQR1XS
CHP-126 NYeyPZd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7zTWM2OD1{MT60OFYzKM7:TR?= NYLFWGppW0GQR1XS
SW837 M1vIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJzLkS5N|kh|ryP MUjTRW5ITVJ?
SHP-77 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXDXWlVUUN3ME2yNU43OTJ{IN88US=> Ml;TV2FPT0WU
DB Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJzLk[xOFIh|ryP MX3TRW5ITVJ?
ES5 NE\wTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJzLk[4OlQh|ryP NYrMeoNPW0GQR1XS
COR-L23 NYH2W4ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULFWlBiUUN3ME2yNU45ODVzIN88US=> M3i3[nNCVkeHUh?=
KU-19-19 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjyTWM2OD1{MT64PVgzKM7:TR?= M4TCfHNCVkeHUh?=
T84 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\xN2lEPTB;MkGuPVgyQSEQvF2= NVnJZo5qW0GQR1XS
NCI-H630 NVzocXF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XXXWlEPTB;MkKuOVM3OyEQvF2= MWTTRW5ITVJ?
LU-165 NFTIXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO5TWM2OD1{Mj61OVQh|ryP NILoT2ZUSU6JRWK=
COLO-792 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf6OllKSzVyPUKyMlcyOTFizszN MoriV2FPT0WU
CAL-62 NUGyd4FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zQOGlEPTB;MkKuO|UyPyEQvF2= NVTmNYM6W0GQR1XS
HCE-T Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\1emlEPTB;MkKuPFYxPiEQvF2= NHLtPFBUSU6JRWK=
BB65-RCC M1LXbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ|LkCzOFQh|ryP M4j2SnNCVkeHUh?=
SiHa M17ISGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjrW3BlUUN3ME2yN{4{QTZ6IN88US=> NVr0NHZHW0GQR1XS
NCI-H2081 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXaTWM2OD1{ND6wOlQyKM7:TR?= MmTFV2FPT0WU
U251 NGWyR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjhTWM2OD1{ND6wOlY5KM7:TR?= M1LnWXNCVkeHUh?=
LoVo NX\ZUIU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPUXI9JUUN3ME2yOE46Ojh{IN88US=> MXvTRW5ITVJ?
GCIY NXT6TYVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvNOpVKSzVyPUK1MlI5PzdizszN MY\TRW5ITVJ?
NUGC-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJ3LkOzNVYh|ryP MYrTRW5ITVJ?
LNCaP-Clone-FGC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\TW2FqUUN3ME2yOU4{PDl6IN88US=> NGD1e4lUSU6JRWK=
PA-1 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7YTWM2OD1{NT62PFM{KM7:TR?= MX;TRW5ITVJ?
OE33 M4X5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7GOnR{UUN3ME2yOU43QDV|IN88US=> MmrKV2FPT0WU
HT-29 NYjIb5hrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInZeZhKSzVyPUK1Mlc5PzlizszN Mo\2V2FPT0WU
RCM-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jTWM2OD1{NT65OlU3KM7:TR?= NIjxXpJUSU6JRWK=
NCI-H1522 M2iwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknCTWM2OD1{NT65PVEyKM7:TR?= M1yyNnNCVkeHUh?=
LB373-MEL-D NIPOT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLW[|lHUUN3ME2yOk4yPzB6IN88US=> MoC3V2FPT0WU
NCI-H1436 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLiUY5KSzVyPUK2MlI4OzhizszN MYnTRW5ITVJ?
COLO-824 NUfSNW8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPaT|R4UUN3ME2yOk41ODB{IN88US=> MoTlV2FPT0WU
CP50-MEL-B MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJ4LkW2O|Uh|ryP Mnm4V2FPT0WU
EGI-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2e1ZmlEPTB;MkeuNlY6QCEQvF2= NWTqe3RrW0GQR1XS
LAN-6 NUHieFNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ5LkO1PVgh|ryP MWLTRW5ITVJ?
GAK MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJ5LkSyNlUh|ryP NVrOS3hXW0GQR1XS
MDA-MB-175-VII MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfJOWZKSzVyPUK3MlUxPTNizszN NEDQR|NUSU6JRWK=
JVM-2 M{P1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJ5Lk[2NlIh|ryP M2XOOHNCVkeHUh?=
UACC-257 MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nGdmlEPTB;MkeuOlg4QCEQvF2= NVyzepU6W0GQR1XS
SW1783 Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ5Lke3PFMh|ryP NELNOGNUSU6JRWK=
HT-3 M1PjVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqzVGsxUUN3ME2yPE4zOTZ4IN88US=> MVzTRW5ITVJ?
RL MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXjPWlKSzVyPUK4MlU6OTFizszN NUWxNFNlW0GQR1XS
TK10 NXPwboRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXEfo9wUUN3ME2yPE43PTN3IN88US=> NV;kSmczW0GQR1XS
HT55 NYq1TmJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrjbG9KSzVyPUK5MlA2PjVizszN NEm2WmxUSU6JRWK=
BT-20 MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUezcWd4UUN3ME2yPU4xPTh4IN88US=> M4j1bXNCVkeHUh?=
TGBC24TKB NHX5VVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XoOWlEPTB;MkmuNVg{OSEQvF2= MW\TRW5ITVJ?
HSC-2 M2HKNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvj[2JKSzVyPUK5MlMxODFizszN MUnTRW5ITVJ?
COLO-205 NUnwUHJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDROoxWUUN3ME2yPU4{QTR2IN88US=> NXjrO25SW0GQR1XS
GT3TKB NGTUSm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7vTWM2OD1{OT62PFc4KM7:TR?= NIfRdmpUSU6JRWK=
T47D NH3NT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y3XGlEPTB;MkmuPFU5OiEQvF2= MVTTRW5ITVJ?
OMC-1 NHW0ToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PxeWlEPTB;M{CuNVkyQSEQvF2= NIXMdGpUSU6JRWK=
PFSK-1 NXf6[GM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfSfIFKSzVyPUOxMlI3PTlizszN NHvSZ5pUSU6JRWK=
JEG-3 NITCVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnO[WdKSzVyPUOxMlM2PjFizszN NVexZWpHW0GQR1XS
RD MnzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O0UmlEPTB;M{GuOVEyPSEQvF2= Ml3GV2FPT0WU
NCI-H64 NHL5TXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\WNnBKSzVyPUOyMlQyPzlizszN NFHVPIpUSU6JRWK=
DMS-114 MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2zZYFKSzVyPUOyMlQyQDJizszN MlHkV2FPT0WU
NCI-H661 NIS1VFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTN{Lk[1NFEh|ryP Ml7DV2FPT0WU
CAL-148 MoXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljDTWM2OD1|Mj62OlY2KM7:TR?= NGPjN|RUSU6JRWK=
HuP-T3 M2KxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojITWM2OD1|Mj65N|M5KM7:TR?= MXLTRW5ITVJ?
ES4 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom2TWM2OD1|Mz6xO|A2KM7:TR?= NHrhXFRUSU6JRWK=
Ca9-22 NXTIe3U4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vCWWlEPTB;M{OuOFYxOSEQvF2= MVLTRW5ITVJ?
LP-1 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTN2LkC5JO69VQ>? MkjrV2FPT0WU
AU565 NWHBWo9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS0NpZpUUN3ME2zOE42ODZ7IN88US=> M1HpRnNCVkeHUh?=
MDA-MB-453 M1H5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnh[nRKSzVyPUO1MlE1OjZizszN MoHpV2FPT0WU
SNU-C1 Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN3LkG3NUDPxE1? MX;TRW5ITVJ?
SW13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\OZ2lEPTB;M{WuOFA4PiEQvF2= MWfTRW5ITVJ?
NCI-H2122 NVqwNmYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LtTmlEPTB;M{WuOVU6QCEQvF2= M4TOPXNCVkeHUh?=
NCI-H1395 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HGc2lEPTB;M{WuOlY6OSEQvF2= MVjTRW5ITVJ?
J-RT3-T3-5 M{X5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTN4LkCyPVQh|ryP MULTRW5ITVJ?
COR-L279 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;wTWM2OD1|Nj6xPVgyKM7:TR?= NVLBRphSW0GQR1XS
ATN-1 M{TyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe4cJpNUUN3ME2zOk45PTF4IN88US=> NEn4PJVUSU6JRWK=
HCC2998 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i3c2lEPTB;M{[uPFU4OSEQvF2= NW\6[4lDW0GQR1XS
UM-UC-3 M{PCWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLXTWM2OD1|Nj64Olc2KM7:TR?= NFnBVZRUSU6JRWK=
DV-90 M3z5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\QNZVKSzVyPUO2MlkxPjdizszN M3zDenNCVkeHUh?=
ES8 MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHoTWM2OD1|Nj65N|E5KM7:TR?= NEPlTWZUSU6JRWK=
YAPC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT1bWppUUN3ME2zOk46PjV2IN88US=> M1LiTHNCVkeHUh?=
HCC1599 NH3IO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXU[2JwUUN3ME2zO{4yPjF6IN88US=> MWfTRW5ITVJ?
UMC-11 NV31TXdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDaTWM2OD1|Nz6yOVA{KM7:TR?= M{HlVnNCVkeHUh?=
THP-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTvNZBJUUN3ME2zO{4zQDZ6IN88US=> NVnJTFVMW0GQR1XS
OCUB-M NXvxWIJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnryTWM2OD1|Nz6yPFkyKM7:TR?= NX;Cc4dEW0GQR1XS
NCI-H1693 NXjHfot{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O0cGlEPTB;M{euN|I{OyEQvF2= MUnTRW5ITVJ?
NCI-H345 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\YTWM2OD1|Nz6zOlI1KM7:TR?= MVXTRW5ITVJ?
COLO-800 M{jjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13xVWlEPTB;M{euOVY4KM7:TR?= M1KzZ3NCVkeHUh?=
COLO-320-HSR MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrpR|dCUUN3ME2zPE4{PDl{IN88US=> MWPTRW5ITVJ?
NCI-H596 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN6LkS0PFkh|ryP MmH5V2FPT0WU
NCI-H187 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjlUHQ{UUN3ME2zPE44OzR2IN88US=> NWHkWVZ7W0GQR1XS
ECC4 MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XGXGlEPTB;M{muNFgyPCEQvF2= NF3JfoRUSU6JRWK=
KP-4 NGDRNJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN7LkGyN|Uh|ryP M2fZ[XNCVkeHUh?=
NCI-H2227 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3xd5hKSzVyPUO5MlM6PDlizszN NYLDWnRpW0GQR1XS
22RV1 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITyfmZKSzVyPUO5Mlg{QThizszN MWDTRW5ITVJ?
SAS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Hxc2lEPTB;NECuNFk3KM7:TR?= MU\TRW5ITVJ?
PANC-10-05 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq2cmF7UUN3ME20NE4yQDJ6IN88US=> MoXIV2FPT0WU
MDA-MB-468 NUC0fnJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fhdWlEPTB;NECuOVM1PiEQvF2= NXLDR2RqW0GQR1XS
RPMI-7951 NXTa[VVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfXWJAxUUN3ME20NU4zODd3IN88US=> NGPyOWFUSU6JRWK=
BB49-HNC M4GwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3JSFZKSzVyPUSxMlIyPzlizszN MljZV2FPT0WU
23132-87 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG0dYprUUN3ME20NU4zPzN{IN88US=> MYLTRW5ITVJ?
HCC1569 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3QTWM2OD12MT6yPFg2KM7:TR?= NUTPfYlGW0GQR1XS
CP66-MEL NYnWWXR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTR{LkG4PFYh|ryP NFLjU|FUSU6JRWK=
K-562 MnjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTR{LkK4OVQh|ryP NWrqV2hIW0GQR1XS
OCI-AML2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjmPWp2UUN3ME20Nk45QTd2IN88US=> M{jvXnNCVkeHUh?=
SW756 NXfy[WhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTR|LkCzPFgh|ryP NW[1d5JOW0GQR1XS
M14 NFq0e|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTibHlKSzVyPUSzMlMyQDlizszN NVLXcmQ2W0GQR1XS
NCI-H1623 NIDXSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXUOGtKSzVyPUSzMlQ3PCEQvF2= MnrlV2FPT0WU
KNS-81-FD MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLaTWM2OD12Mz63OlIh|ryP MoT5V2FPT0WU
TGBC1TKB M2nhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17BR2lEPTB;NEOuPVA6QSEQvF2= M3fmTHNCVkeHUh?=
RERF-LC-MS NVK1fJhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTR|LkmyPFEh|ryP M2XaeXNCVkeHUh?=
PC-3 NWrTTlh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPUb|h[UUN3ME20OE41OzR5IN88US=> MkTrV2FPT0WU
HuP-T4 NEHXNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEToUnpKSzVyPUS0MlQ1PzRizszN M3\l[XNCVkeHUh?=
NCI-H510A MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LrSmlEPTB;NESuO|A5KM7:TR?= MY\TRW5ITVJ?
LB2518-MEL MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrYTWM2OD12ND63PVM4KM7:TR?= MUnTRW5ITVJ?
TE-5 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPR[nQ5UUN3ME20OU46PThzIN88US=> NYe5OphFW0GQR1XS
EW-24 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj1[VRKSzVyPUS2MlE4OjNizszN M1vDVXNCVkeHUh?=
LB647-SCLC NWXvfWVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P5PWlEPTB;NE[uNlE2PSEQvF2= NULKWGhjW0GQR1XS
NCI-H524 NHfNW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M16yXGlEPTB;NE[uO|E5PSEQvF2= MXXTRW5ITVJ?
EW-11 NIC2OHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3jNXBKSzVyPUS2Mlk{PzNizszN MX3TRW5ITVJ?
KALS-1 NHq3e5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTCNXJKSzVyPUS3MlIxPjZizszN NHuzXGVUSU6JRWK=
BT-474 NWm5eJAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\YNm1KSzVyPUS3MlQzOTZizszN M{[yS3NCVkeHUh?=
SK-N-AS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTR5Lki4PEDPxE1? NV3MOIhOW0GQR1XS
HCC2157 NXPwc2gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\tTWM2OD12OD6wO|Yh|ryP MojaV2FPT0WU
HCC1954 NYHM[5JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK1VWdKSzVyPUS4MlE4ODRizszN NGXFeFBUSU6JRWK=
FADU NWX4dVdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;ZV4NKSzVyPUS4MlMxOzFizszN MUfTRW5ITVJ?
S-117 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TZWmlEPTB;NEiuN|gyPSEQvF2= NGTn[XNUSU6JRWK=
LS-1034 NVf3WmxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTR6LkewOlch|ryP NEi2[WlUSU6JRWK=
CAMA-1 NGPxO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:4dmlEPTB;NEmuOVU1OyEQvF2= M4XJPXNCVkeHUh?=
LU-134-A NGnWW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3OzXGlEPTB;NEmuPFA5PSEQvF2= NVTxeFZpW0GQR1XS
NCI-H1838 NGHKUphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR7LkiwPFch|ryP MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04070443 Not yet recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard October 1 2019 Phase 2
NCT03934372 Not yet recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation October 25 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID