Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37qbGlEPTB;MD6wNFAxODByM{W5JO69VQ>? NIGwVIpUSU6JRWK=
MV-4-11 NWnrNolUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGzWmVKSzVyPUCuNFAxODl3NjFOwG0> NVrrfIdZW0GQR1XS
MEG-01 M1vIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf1TWhRUUN3ME2wMlAxODF{ODFOwG0> NY\jcYw5W0GQR1XS
LAMA-84 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ETWlEPTB;MD6wNFAyPjVizszN NGmyOpJUSU6JRWK=
CGTH-W-1 NYTVXFZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvTfXhkUUN3ME2wMlAxOTZ7IN88US=> NHTLTnVUSU6JRWK=
KASUMI-1 NGO0PYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7GVZVKSzVyPUCuNFAzOTdizszN NIXXZ3dUSU6JRWK=
BE-13 MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f1dmlEPTB;MD6wNFI2QSEQvF2= MmHnV2FPT0WU
CTV-1 NWTh[nBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2mxcmlEPTB;MD6wNFUzOSEQvF2= MVnTRW5ITVJ?
NKM-1 NGjWfHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHVTWM2OD1yLkCwOlU2KM7:TR?= MYLTRW5ITVJ?
MONO-MAC-6 NIX0[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr2R5UzUUN3ME2wMlAxQDN5IN88US=> M4npNXNCVkeHUh?=
A204 Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi4TWM2OD1yLkCxNlE5KM7:TR?= M3X0WHNCVkeHUh?=
GDM-1 MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPYZ|VKSzVyPUCuNFE5OzNizszN MlfsV2FPT0WU
AN3-CA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTuRoZKSzVyPUCuNFE5PzNizszN MlHDV2FPT0WU
BL-70 NYLUTFlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvWfYZKSzVyPUCuNFIyQTlizszN M2PVNHNCVkeHUh?=
Daudi NFLkTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fOc2lEPTB;MD6wNlU{PyEQvF2= MVjTRW5ITVJ?
KU812 M1;ifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\3R2lEPTB;MD6wNlg1QCEQvF2= MVfTRW5ITVJ?
KG-1 M1nUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fLRmlEPTB;MD6wN|I6PCEQvF2= MYDTRW5ITVJ?
DOHH-2 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n1UWlEPTB;MD6wOFgxOyEQvF2= NEj2R|NUSU6JRWK=
HuO9 NYHXbG1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH2TWM2OD1yLkC1OFQ5KM7:TR?= M17XenNCVkeHUh?=
EB2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDHe3BrUUN3ME2wMlA2PTd4IN88US=> NG\yUY1USU6JRWK=
G-402 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrqTWM2OD1yLkC2N|QyKM7:TR?= M1nMcnNCVkeHUh?=
SU-DHL-1 NH;zRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\Je5BuUUN3ME2wMlA3Ozd7IN88US=> NIL0ZZdUSU6JRWK=
NCI-H719 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkniTWM2OD1yLkC3PFg5KM7:TR?= MlviV2FPT0WU
MLMA NWLLe3g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;qWWFKSzVyPUCuNFkxPiEQvF2= M2fGR3NCVkeHUh?=
KM12 MkLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPuTYtlUUN3ME2wMlA6PzN5IN88US=> MVnTRW5ITVJ?
SUP-T1 M4jxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEm5PFIh|ryP MYnTRW5ITVJ?
MZ1-PC MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljKTWM2OD1yLkGxN|M3KM7:TR?= MmD1V2FPT0WU
MFE-296 Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTxW5lKSzVyPUCuNVE5OzlizszN MXTTRW5ITVJ?
ALL-PO M1Ow[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rIfGlEPTB;MD6xNlQ1OyEQvF2= NHi5SWRUSU6JRWK=
GB-1 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPZ[ZJwUUN3ME2wMlEzPTF{IN88US=> M3S1cXNCVkeHUh?=
SIG-M5 NFzvcIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUOzO{DPxE1? NIXTUlZUSU6JRWK=
P30-OHK M{XVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7iSFlKSzVyPUCuNVU3PzJizszN NYHyPGRCW0GQR1XS
NCI-H716 NXLoZlgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTrUo9EUUN3ME2wMlE3OjZ4IN88US=> MnPkV2FPT0WU
MPP-89 NYH1VWhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMU[5N|Mh|ryP MYLTRW5ITVJ?
SF126 NFLqSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\ESmlEPTB;MD6xO|A3OyEQvF2= M1TkOHNCVkeHUh?=
CTB-1 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMUezNVYh|ryP M3HE[3NCVkeHUh?=
CA46 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT1SmM3UUN3ME2wMlE4PDh7IN88US=> M2rBc3NCVkeHUh?=
NCI-H520 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO0OlhKSzVyPUCuNVc4OzJizszN Ml;RV2FPT0WU
CAL-85-1 MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvB[3lKSzVyPUCuNVc6OjdizszN NUf3T5VHW0GQR1XS
NCI-H2342 M3TlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;zTWM2OD1yLkG4OVc4KM7:TR?= NXT6W3gzW0GQR1XS
697 NIi0T2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXqTWM2OD1yLkG4PFcyKM7:TR?= MXrTRW5ITVJ?
NY MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\v[olKSzVyPUCuNVkzQDdizszN NVmzVpByW0GQR1XS
T98G MoHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMUmzNVgh|ryP Mmq4V2FPT0WU
NCI-H1703 NHvwem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS1emp5UUN3ME2wMlE6PjF3IN88US=> M{X3VnNCVkeHUh?=
NCI-H2087 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7TSpdnUUN3ME2wMlIxPDN7IN88US=> M3PhZnNCVkeHUh?=
PF-382 M36yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMkC4O|Mh|ryP NWfBVldOW0GQR1XS
HCT-116 M3[2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMkGwOlkh|ryP NULvSHl{W0GQR1XS
CAKI-1 NF\VNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjtXGRjUUN3ME2wMlIyPjZ4IN88US=> NYnHTXNxW0GQR1XS
CCF-STTG1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\Mc5M2UUN3ME2wMlIzPDd3IN88US=> MXTTRW5ITVJ?
D-392MG MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInpZmpKSzVyPUCuNlMyPzdizszN MYDTRW5ITVJ?
RT-112 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLtTWM2OD1yLkKzO|k2KM7:TR?= MmrOV2FPT0WU
MES-SA MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j2VGlEPTB;MD6yOFE5PyEQvF2= MWrTRW5ITVJ?
LC-2-ad MkjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLiTWM2OD1yLkK0NlY2KM7:TR?= M3zBVnNCVkeHUh?=
NOS-1 MoWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nlOmlEPTB;MD6yOFM3PyEQvF2= M2fXWHNCVkeHUh?=
NALM-6 M1T1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\3TWM2OD1yLkK1OVQ{KM7:TR?= NIPpe2FUSU6JRWK=
TE-15 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMk[wPVEh|ryP NFn4RXhUSU6JRWK=
786-0 M4XFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMk[yNlgh|ryP NGnJSo1USU6JRWK=
IST-MES1 NYjmWG04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrXTWM2OD1yLkK2PFI6KM7:TR?= M3Lac3NCVkeHUh?=
KYSE-180 NV7JSoRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\iPWlEPTB;MD6yOlg6OSEQvF2= MWjTRW5ITVJ?
YT NYXXfIdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e5OGlEPTB;MD6yOlk4PCEQvF2= MXnTRW5ITVJ?
A427 NUXk[oVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjETWM2OD1yLkK3NlY1KM7:TR?= M1i0enNCVkeHUh?=
KYSE-450 NXvVbW56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMkezNlkh|ryP MmTCV2FPT0WU
HuH-7 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7zOmJEUUN3ME2wMlI4PzZ|IN88US=> NI\CfY1USU6JRWK=
CAS-1 NHrV[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jZWGlEPTB;MD6yPFMxOyEQvF2= M3fzZnNCVkeHUh?=
KURAMOCHI NHLuSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS2coJVUUN3ME2wMlI5PDF7IN88US=> NWO3UmJ1W0GQR1XS
ACHN NHz2U3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3JdJBKSzVyPUCuNlk{OjNizszN M4LKPXNCVkeHUh?=
HGC-27 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PpV2lEPTB;MD6yPVM2OyEQvF2= M2PSfXNCVkeHUh?=
A172 NETqbJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\BPIQ2UUN3ME2wMlI6PTd5IN88US=> M33HUHNCVkeHUh?=
SNU-449 NUfBN5I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLMXpVKSzVyPUCuNlk6PjRizszN MWXTRW5ITVJ?
SW982 M2\CO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMkm5O|gh|ryP M1vjSXNCVkeHUh?=
EFO-21 Mn6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwM{C0NVEh|ryP NHnIO3NUSU6JRWK=
NCI-H2030 NELtW5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHLUmZKSzVyPUCuN|EyPjRizszN NWfEW4F[W0GQR1XS
HT-144 NEHldGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzJUZJKSzVyPUCuN|EzQCEQvF2= MUfTRW5ITVJ?
MFE-280 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHRTWM2OD1yLkOxOFU{KM7:TR?= MorqV2FPT0WU
SK-LU-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnNV3hYUUN3ME2wMlMyPDZ4IN88US=> MUfTRW5ITVJ?
NCI-H2052 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwM{G0PFQh|ryP MlzDV2FPT0WU
SK-HEP-1 M2DIZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHT[lNKSzVyPUCuN|M{PjhizszN NHu4VJJUSU6JRWK=
QIMR-WIL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n5VmlEPTB;MD6zN|QzPCEQvF2= NXT6SVZUW0GQR1XS
A2780 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PtT2lEPTB;MD6zOFMxPCEQvF2= MoXJV2FPT0WU
ACN M3;SWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnCWYwzUUN3ME2wMlM1QDd|IN88US=> NHXhOHFUSU6JRWK=
BxPC-3 NHPJOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH5TWM2OD1yLkO0PVg6KM7:TR?= M2DXVnNCVkeHUh?=
BCPAP M176N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HLdWlEPTB;MD6zOlAxOSEQvF2= NEPHTmVUSU6JRWK=
HOP-62 M2jVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwM{[xNFYh|ryP MUHTRW5ITVJ?
SW1710 M3;FdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37tUGlEPTB;MD6zOlQ2PSEQvF2= NGnqUYNUSU6JRWK=
OPM-2 NFvPOnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLBTWM2OD1yLkO2OFc{KM7:TR?= MnXFV2FPT0WU
DBTRG-05MG MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TrT2lEPTB;MD6zPFA2PCEQvF2= NFnEWVFUSU6JRWK=
SK-MEL-24 M1H6[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3YZo9KSzVyPUCuN|k4QTFizszN NWjaOXhUW0GQR1XS
8305C M1\hdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwM{m3PVMh|ryP MUDTRW5ITVJ?
OVCAR-4 NYT0U5c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S4cGlEPTB;MD60NVU5PiEQvF2= MlfnV2FPT0WU
HLE NUnnZ2hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DzcmlEPTB;MD60NVg3KM7:TR?= NFrNNmdUSU6JRWK=
NCI-H747 NV;MVVlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwNEKxN|ch|ryP NYexN2xtW0GQR1XS
SW780 NGrRflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX6S3B[UUN3ME2wMlQzOzR4IN88US=> MUHTRW5ITVJ?
KYSE-150 NEXVcm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlviTWM2OD1yLkSyOFE2KM7:TR?= M4LCd3NCVkeHUh?=
H4 MlTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXrcYc4UUN3ME2wMlQzPDVzIN88US=> NE\MWZlUSU6JRWK=
SW1088 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XCWWlEPTB;MD60OFM6KM7:TR?= MVHTRW5ITVJ?
SF268 NVXrO4NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljjTWM2OD1yLkS0PFYh|ryP NYrWcmdmW0GQR1XS
RT4 M{XTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XadWlEPTB;MD60OVEyOSEQvF2= NF7JVZhUSU6JRWK=
NCI-H522 NFe1bo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwNEWyO{DPxE1? MW\TRW5ITVJ?
LCLC-97TM1 M33mWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf5TY5KSzVyPUCuOFYyQTVizszN NUP5dlQyW0GQR1XS
CAL-39 NY\2NYJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNE[1NVkh|ryP NXrlN3RHW0GQR1XS
CAL-120 NFflTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fhNWlEPTB;MD60O|Y1OyEQvF2= NV7ScpllW0GQR1XS
ESS-1 NYPCc2tPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzv[GdKSzVyPUCuOFc5OjFizszN NXLvOm9LW0GQR1XS
KARPAS-45 NILVc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwNEi5N|Mh|ryP NXfnWHV4W0GQR1XS
DU-4475 NGO3fWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi3T4oxUUN3ME2wMlQ6PTFzIN88US=> NInGPVJUSU6JRWK=
VMRC-RCZ MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzKblM{UUN3ME2wMlQ6QTB2IN88US=> M4XMfHNCVkeHUh?=
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KNS-42 MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\NTWM2OD1zLki2NlY3KM7:TR?= NH;ZephUSU6JRWK=
NCI-H2452 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vQRWlEPTB;MT64PVA4PCEQvF2= NE\BWXJUSU6JRWK=
SK-MEL-2 NWLzWW1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{i0O2lEPTB;MT65NFI4OSEQvF2= MoTCV2FPT0WU
OVCAR-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr1PIhKSzVyPUGuPVA3PzVizszN M1Gwc3NCVkeHUh?=
SNG-M MlPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LyTWlEPTB;MT65OVg2QCEQvF2= MojTV2FPT0WU
A673 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPITWM2OD1zLkm3OVE3KM7:TR?= NGX3V2ZUSU6JRWK=
L-428 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXTU45KSzVyPUGuPVkyPzlizszN M4jHcHNCVkeHUh?=
KM-H2 NGHrO5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTzOXVKSzVyPUKuNFExQSEQvF2= NHXSR2VUSU6JRWK=
MC-IXC NYj0dlhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PqS2lEPTB;Mj6wNlI4OyEQvF2= MnnwV2FPT0WU
COLO-678 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXucllKSzVyPUKuNFQzODdizszN NFfqNopUSU6JRWK=
MEL-JUSO M{LjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu1TWM2OD1{LkC3PFUyKM7:TR?= NYTocIh7W0GQR1XS
HCC38 NYH5ZnpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\0cVA{UUN3ME2yMlA5PDN|IN88US=> M1fT[HNCVkeHUh?=
UACC-62 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonJTWM2OD1{LkC4PFU2KM7:TR?= MWfTRW5ITVJ?
OAW-42 NIruN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3uWIRKSzVyPUKuNFk4OTFizszN NU\MV3F1W0GQR1XS
LB996-RCC M4m5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwMUO4NVch|ryP NUjNWWdMW0GQR1XS
COR-L105 NV;aXJp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJwMU[zO|Mh|ryP MWrTRW5ITVJ?
RCC10RGB M4iyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr4R|N3UUN3ME2yMlE5PTd4IN88US=> NWPJXmJsW0GQR1XS
A431 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j2[GlEPTB;Mj6xPVAyQSEQvF2= M37adnNCVkeHUh?=
NCI-H292 NGTaOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj6fphKSzVyPUKuNlM6PTFizszN NF7h[GhUSU6JRWK=
SK-UT-1 M{Dz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G1ZmlEPTB;Mj6zN|E5PCEQvF2= MoXUV2FPT0WU
PANC-08-13 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;BT3VKSzVyPUKuN|MzOzVizszN NIC3RlhUSU6JRWK=
ST486 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDWTWM2OD1{LkSxNFQ5KM7:TR?= NUG0fFAxW0GQR1XS
SJSA-1 MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTqTWM2OD1{LkSxNlcyKM7:TR?= MX3TRW5ITVJ?
RKO NUPrfGZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP3coE5UUN3ME2yMlQzODJ7IN88US=> M1PR[nNCVkeHUh?=
NCI-H1793 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJwNESwNlkh|ryP NY\pfYk1W0GQR1XS
639-V NUf4ZlkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX2VHZKSzVyPUKuOFU{QDJizszN NUX2OJZKW0GQR1XS
ES3 M3rJU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJwNEm3N|ch|ryP M4nDPHNCVkeHUh?=
NCI-H1792 M3THNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe4dmJKSzVyPUKuOVY5OjZizszN MXPTRW5ITVJ?
NCI-H1651 NFTEN3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUixbG1GUUN3ME2yMlU5OjFizszN MYLTRW5ITVJ?
SN12C M1Hycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTNSmVKSzVyPUKuOVg1QDdizszN MlPvV2FPT0WU
COLO-679 NYGzUllET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDKTWM2OD1{LkW4OlA2KM7:TR?= MUPTRW5ITVJ?
U-118-MG NGrOXFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHDe5U{UUN3ME2yMlU5QDd{IN88US=> Mo\oV2FPT0WU
Ramos-2G6-4C10 NF3vcHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ridmlEPTB;Mj62OFgxPyEQvF2= NGXZe2JUSU6JRWK=
HCT-15 M3Tjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\aWWlEPTB;Mj62PFc6OiEQvF2= MVnTRW5ITVJ?
MDA-MB-157 M4Luc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPCRnFlUUN3ME2yMlcxPzR5IN88US=> Ml;3V2FPT0WU
K5 M1nufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XD[2lEPTB;Mj63NVg1PSEQvF2= NV3Ce3pbW0GQR1XS
MKN45 NFf6bJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDDTWM2OD1{LkezN|Y3KM7:TR?= M3HWfHNCVkeHUh?=
DMS-273 M33tVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJwN{W2N|Ih|ryP MUHTRW5ITVJ?
C8166 NXyxTm5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJwN{i1NVMh|ryP MlTmV2FPT0WU
Calu-3 NG[5[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXO[ldKSzVyPUKuO|g6PjlizszN MV3TRW5ITVJ?
SNB75 NHv6WpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJwOEi1N|Uh|ryP NEHoN5JUSU6JRWK=
BFTC-905 NVfuNYM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJwOUCxPVEh|ryP MnvUV2FPT0WU
C-4-II M2\V[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;zNIZKSzVyPUKuPVE{PTNizszN M{jZcXNCVkeHUh?=
MS-1 NWnT[HVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTJwOU[3Olkh|ryP NHnsbI1USU6JRWK=
A375 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTNwMEixPFQh|ryP NVe0dnlxW0GQR1XS
KYSE-70 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTNwMEi4PFIh|ryP M2S2W3NCVkeHUh?=
KYSE-510 M2\YNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTjd3RDUUN3ME2zMlExQTl3IN88US=> M4LGNnNCVkeHUh?=
LN-405 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm2TWM2OD1|LkGzOVE5KM7:TR?= MYrTRW5ITVJ?
BOKU M1Loemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDzTWM2OD1|LkG0NlU3KM7:TR?= MofzV2FPT0WU
TE-10 NV\GcHJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjF[W03UUN3ME2zMlE4OzZ{IN88US=> MWrTRW5ITVJ?
MKN1 NH\NN4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrpUGZ7UUN3ME2zMlE5PDh|IN88US=> M1r1SXNCVkeHUh?=
M059J MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn0TWM2OD1|LkKwNVc{KM7:TR?= NVvROo5EW0GQR1XS
GOTO MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPXdWtSUUN3ME2zMlIzODN7IN88US=> NF25fJRUSU6JRWK=
DK-MG M2Dhfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnBTWM2OD1|LkK1PVc3KM7:TR?= MY\TRW5ITVJ?
NCI-H727 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNwMk[1PEDPxE1? M3rkb3NCVkeHUh?=
NB12 NV7BR2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonsTWM2OD1|LkOzNlI1KM7:TR?= M{LwOnNCVkeHUh?=
DOK M2LQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D2NmlEPTB;Mz6zOlE5PiEQvF2= NF\o[3hUSU6JRWK=
KYSE-410 M{fvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jYOWlEPTB;Mz6zOlI5PyEQvF2= NHrsfYFUSU6JRWK=
AM-38 NEntfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\BTpY3UUN3ME2zMlM5ODVzIN88US=> NFTjfmNUSU6JRWK=
GR-ST M{jHN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfrNXZWUUN3ME2zMlQ2PzN{IN88US=> M1r6NnNCVkeHUh?=
D-247MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNwNEiyOlMh|ryP NGK1V4FUSU6JRWK=
TE-8 Mlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PhdWlEPTB;Mz60PVM{OyEQvF2= M{L1TnNCVkeHUh?=
LS-411N NHvJbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7ETWM2OD1|LkS5OlkzKM7:TR?= NGLyVZBUSU6JRWK=
SK-MES-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nwcGlEPTB;Mz61OlQ{OyEQvF2= MV7TRW5ITVJ?
SF295 NUm3WldDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfWcmw2UUN3ME2zMlYyPTV{IN88US=> NVHQVG1vW0GQR1XS
SK-MEL-30 NEO5NVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jQT2lEPTB;Mz62OVkzOSEQvF2= NFHjd3VUSU6JRWK=
LB2241-RCC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCxTWM2OD1|Lk[2NlYh|ryP MVnTRW5ITVJ?
PC-14 NVKyTGRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwNk[0N|ch|ryP NEXOV4FUSU6JRWK=
EW-7 NXPh[YVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NISyfZhKSzVyPUOuOlc3QTNizszN M{fmOXNCVkeHUh?=
NMC-G1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPEcFJKSzVyPUOuO|E5OzdizszN M3[2VnNCVkeHUh?=
TE-441-T Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPHS|NKSzVyPUOuO|MxOjhizszN M2H5RnNCVkeHUh?=
NCI-H1618 NEjWNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf5TWM2OD1|LkixPFc2KM7:TR?= NYTyRVd6W0GQR1XS
PANC-03-27 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTNwOEG5NVYh|ryP MlTMV2FPT0WU
NCI-H2228 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLFe3lKSzVyPUOuPFMyOjZizszN NF2xc2ZUSU6JRWK=
CAPAN-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTNwOEewNFkh|ryP MWjTRW5ITVJ?
KLE NVrsR5lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvTTWM2OD1|LkmwOlch|ryP MX7TRW5ITVJ?
Becker NF3lRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\zTWM2OD1|LkmyPFQ6KM7:TR?= M17CVHNCVkeHUh?=
SK-PN-DW NEXwZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTtfVdRUUN3ME20MlA4QTd2IN88US=> Mlm1V2FPT0WU
Hs-578-T MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTRwMEizNFYh|ryP NFrsfYRUSU6JRWK=
RS4-11 NWfYUIdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTRwMUGyOVUh|ryP M2\WWnNCVkeHUh?=
D-502MG M4XOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTRwMU[5PVch|ryP M{fafXNCVkeHUh?=
GI-1 NYjMU3l{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfub5VKSzVyPUSuNlgzQTlizszN NVu3RnBEW0GQR1XS
NCI-H209 NF7FcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W3SGlEPTB;ND6zN|c5KM7:TR?= MXfTRW5ITVJ?
SK-OV-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnhb|hKSzVyPUSuOFgyPDlizszN M4njVXNCVkeHUh?=
LOUCY MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK4TWM2OD12LkS4OFMzKM7:TR?= MYPTRW5ITVJ?
NCI-H69 M2WzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULLWnE1UUN3ME20MlUyPzl|IN88US=> NUnvNnE6W0GQR1XS
SCC-9 NGLRRotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlriTWM2OD12LkWzNVczKM7:TR?= NWDFXmdJW0GQR1XS
NCI-H526 M{\KbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLkTWM2OD12LkW5Nlk{KM7:TR?= NVnVUnBLW0GQR1XS
NCI-H2170 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[xTWM2OD12Lk[2O|cyKM7:TR?= M1XTXnNCVkeHUh?=
SR M4PUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK1TWM2OD12LkewNFQ5KM7:TR?= M3vLS3NCVkeHUh?=
CMK NEDWN|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TsRWlEPTB;ND63NlExOSEQvF2= M1HhOHNCVkeHUh?=
COLO-829 NVvTNWhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTRwN{ewOFMh|ryP MkTuV2FPT0WU
HuO-3N1 NH2ye4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfTPGVKSzVyPUSuPFMzQDFizszN MXPTRW5ITVJ?
5637 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTRwOUC0PFch|ryP MWfTRW5ITVJ?
A253 NYnqe5lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrzXVN3UUN3ME20Mlk4PzB6IN88US=> MY\TRW5ITVJ?
NB10 NWDWNYRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTVwMEe0PVch|ryP NHPFfYRUSU6JRWK=
SF539 NGfxXJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHtZYpKSzVyPUWuNFk6PTlizszN NWrSU3F2W0GQR1XS
HAL-01 NHnzWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmroTWM2OD13LkG0OlQ2KM7:TR?= MkPBV2FPT0WU
MHH-ES-1 NVnLWFk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTVwMU[5NlUh|ryP NVzFO2oxW0GQR1XS
DEL Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\HZlJZUUN3ME21MlI4PTh{IN88US=> M2fLSHNCVkeHUh?=
NCI-H1299 MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;acGlEPTB;NT6zOVAxPyEQvF2= NEK2bYRUSU6JRWK=
ChaGo-K-1 NHfBcoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXXbXpQUUN3ME21MlM2OTB5IN88US=> M33DUnNCVkeHUh?=
HMV-II MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn0TJF5UUN3ME21MlM6PDNizszN NULSN4pvW0GQR1XS
NB69 NFu3ZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1L1S2lEPTB;NT6zPVY{OSEQvF2= NEe3N|RUSU6JRWK=
NCI-H1882 NIfNeotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfNTWM2OD13LkSzN|Y1KM7:TR?= NVG2WnlzW0GQR1XS
SNU-475 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTVwNEexO|Eh|ryP NVryWGg4W0GQR1XS
RXF393 M{X5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTVwNEi0PVQh|ryP MXzTRW5ITVJ?
CAL-51 Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf5TWM2OD13Lk[yPFU{KM7:TR?= MVnTRW5ITVJ?
SW1573 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm3SINlUUN3ME21MlY{PTN2IN88US=> NYTNcZRDW0GQR1XS
GCT MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTQ[|BOUUN3ME21Mlc2QTJ7IN88US=> MoX2V2FPT0WU
COR-L88 NI\XTXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rySmlEPTB;NT63Olg1PiEQvF2= MlrKV2FPT0WU
MDA-MB-134-VI NVrFZWdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn20TWM2OD13Lki3OVM3KM7:TR?= MUfTRW5ITVJ?
NB5 NWT3OWtLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr5TWM2OD13LkmyOFQh|ryP NGHKU5VUSU6JRWK=
GMS-10 NFvWXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\JTWM2OD13Lkm2PFYyKM7:TR?= Moe3V2FPT0WU
CHP-212 M1O4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnETWM2OD14LkS4NlY4KM7:TR?= Mly1V2FPT0WU
TE-11 NHvQS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTZwNUWxPFIh|ryP MVHTRW5ITVJ?
SW962 M{\6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnwTWM2OD14Lk[1O|c1KM7:TR?= M2L2SHNCVkeHUh?=
MZ2-MEL MmLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnyRW5KSzVyPU[uPFIxOTFizszN NVPNNJg4W0GQR1XS
C-33-A NGnSdItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTZwOUG2PFgh|ryP MoPaV2FPT0WU
IGR-1 M3uydmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTZwOUe4NlYh|ryP M1XobnNCVkeHUh?=
MOLT-4 NUHpb4lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknSTWM2OD15LkG1OFA3KM7:TR?= MVjTRW5ITVJ?
NCI-H1650 M1nNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzFV3RKSzVyPUeuNlcxPDZizszN M{e0eHNCVkeHUh?=
AsPC-1 M2HQcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTdwMki2NFUh|ryP NVLLSVZ6W0GQR1XS
SNU-C2B MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\1fVhKSzVyPUeuNlk2PzFizszN NIH5O3NUSU6JRWK=
MKN7 M4KzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\WOGlEPTB;Nz6zO|I{PSEQvF2= M362U3NCVkeHUh?=
SW620 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTdwM{iyNFUh|ryP NGG3XlhUSU6JRWK=
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COLO-792 NVOyUJBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJ{LkexNVEh|ryP MYDTRW5ITVJ?
CAL-62 NWjsRVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfkTJFmUUN3ME2yNk44PTF5IN88US=> M4LaUnNCVkeHUh?=
HCE-T MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HkcWlEPTB;MkKuPFYxPiEQvF2= Mme0V2FPT0WU
BB65-RCC NXH1TXF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJ|LkCzOFQh|ryP M2DrPHNCVkeHUh?=
SiHa NGjyZm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvmTWM2OD1{Mz6zPVY5KM7:TR?= MUfTRW5ITVJ?
NCI-H2081 NGLtS5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO1WnlKSzVyPUK0MlA3PDFizszN NVHpVZl[W0GQR1XS
U251 NGXiTmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjkXZBZUUN3ME2yOE4xPjZ6IN88US=> MV3TRW5ITVJ?
LoVo MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJ2LkmyPFIh|ryP NUC1WplVW0GQR1XS
GCIY M2D6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnhUoxGUUN3ME2yOU4zQDd5IN88US=> M1SxRnNCVkeHUh?=
NUGC-3 NH\uRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ3LkOzNVYh|ryP MWnTRW5ITVJ?
LNCaP-Clone-FGC NYKyUYdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DCNGlEPTB;MkWuN|Q6QCEQvF2= NVfMNmFwW0GQR1XS
PA-1 MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHNTWM2OD1{NT62PFM{KM7:TR?= M4[1O3NCVkeHUh?=
OE33 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXkUFRkUUN3ME2yOU43QDV|IN88US=> MnT4V2FPT0WU
HT-29 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPVeXp[UUN3ME2yOU44QDd7IN88US=> MU\TRW5ITVJ?
RCM-1 NIfDbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ3Lkm2OVYh|ryP M4\zXnNCVkeHUh?=
NCI-H1522 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;1dnpkUUN3ME2yOU46QTFzIN88US=> M4rKVHNCVkeHUh?=
LB373-MEL-D NInpbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWixUHFlUUN3ME2yOk4yPzB6IN88US=> NYXuSFZIW0GQR1XS
NCI-H1436 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;abW5KSzVyPUK2MlI4OzhizszN NVXXTWdbW0GQR1XS
COLO-824 NYXzc45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTVeoNKSzVyPUK2MlQxODJizszN NHnsOZBUSU6JRWK=
CP50-MEL-B MnfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v3dmlEPTB;Mk[uOVY4PSEQvF2= MV3TRW5ITVJ?
EGI-1 M1X1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLWVYtKSzVyPUK3MlI3QThizszN Mlr3V2FPT0WU
LAN-6 MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PvdmlEPTB;MkeuN|U6QCEQvF2= M3;yd3NCVkeHUh?=
GAK NIO5XZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjFd3pWUUN3ME2yO{41OjJ3IN88US=> Mnf2V2FPT0WU
MDA-MB-175-VII M1;2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HQXGlEPTB;MkeuOVA2OyEQvF2= Ml75V2FPT0WU
JVM-2 M3npUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HpPGlEPTB;MkeuOlYzOiEQvF2= NIXWcGdUSU6JRWK=
UACC-257 MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTkOJBKSzVyPUK3MlY5PzhizszN MlPXV2FPT0WU
SW1783 NH2xOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvUSFVKSzVyPUK3Mlc4QDNizszN M{n3UHNCVkeHUh?=
HT-3 MoP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\5W4JOUUN3ME2yPE4zOTZ4IN88US=> NYnob5lUW0GQR1XS
RL M3[1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL1TWM2OD1{OD61PVEyKM7:TR?= MkXRV2FPT0WU
TK10 Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fxfmlEPTB;MkiuOlU{PSEQvF2= M3XGcXNCVkeHUh?=
HT55 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJ7LkC1OlUh|ryP NY\LNFl2W0GQR1XS
BT-20 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJ7LkC1PFYh|ryP Mn;LV2FPT0WU
TGBC24TKB M1XVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PWb2lEPTB;MkmuNVg{OSEQvF2= MkC4V2FPT0WU
HSC-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYeyVW1mUUN3ME2yPU4{ODBzIN88US=> M1HobnNCVkeHUh?=
COLO-205 M2fSS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjUWVd4UUN3ME2yPU4{QTR2IN88US=> MXfTRW5ITVJ?
GT3TKB NFfmVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG5TWM2OD1{OT62PFc4KM7:TR?= M{PqOnNCVkeHUh?=
T47D NIrwNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG5TWM2OD1{OT64OVgzKM7:TR?= NEP6SWZUSU6JRWK=
OMC-1 NXSyd|hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e3ZmlEPTB;M{CuNVkyQSEQvF2= M{Dhc3NCVkeHUh?=
PFSK-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzTWM2OD1|MT6yOlU6KM7:TR?= M1jvOXNCVkeHUh?=
JEG-3 NIL1V4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;y[WlEPTB;M{GuN|U3OSEQvF2= MoH3V2FPT0WU
RD NXn4bHBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;pTWM2OD1|MT61NVE2KM7:TR?= NH7SRnRUSU6JRWK=
NCI-H64 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPZcmxKSzVyPUOyMlQyPzlizszN NVqyWm86W0GQR1XS
DMS-114 NHvyT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTN{LkSxPFIh|ryP M3S2fXNCVkeHUh?=
NCI-H661 NGDkeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLPTWM2OD1|Mj62OVAyKM7:TR?= M{PRdnNCVkeHUh?=
CAL-148 NX;xS49kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTN{Lk[2OlUh|ryP NH7kTYtUSU6JRWK=
HuP-T3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN{LkmzN|gh|ryP MXrTRW5ITVJ?
ES4 NWPHc|R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTN|LkG3NFUh|ryP MmTIV2FPT0WU
Ca9-22 NUPJOIZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;EVG1zUUN3ME2zN{41PjBzIN88US=> M13Hc3NCVkeHUh?=
LP-1 M{TTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nZWmlEPTB;M{SuNFkh|ryP NF[wOY1USU6JRWK=
AU565 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Ph[GlEPTB;M{SuOVA3QSEQvF2= NH\rTIRUSU6JRWK=
MDA-MB-453 NUTISXQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN3LkG0NlYh|ryP MUfTRW5ITVJ?
SNU-C1 M{TTSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjVcGNKSzVyPUO1MlE4OSEQvF2= NInhO5pUSU6JRWK=
SW13 M1vXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3xcmx{UUN3ME2zOU41ODd4IN88US=> NFzLOoJUSU6JRWK=
NCI-H2122 NFPU[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LSOmlEPTB;M{WuOVU6QCEQvF2= M171b3NCVkeHUh?=
NCI-H1395 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonMTWM2OD1|NT62OlkyKM7:TR?= Mn3KV2FPT0WU
J-RT3-T3-5 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnQd4d4UUN3ME2zOk4xOjl2IN88US=> NV3ufHlGW0GQR1XS
COR-L279 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTN4LkG5PFEh|ryP MnvlV2FPT0WU
ATN-1 MnXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljTTWM2OD1|Nj64OVE3KM7:TR?= MUXTRW5ITVJ?
HCC2998 NE\M[5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3oXXpwUUN3ME2zOk45PTdzIN88US=> NVXUXWZ3W0GQR1XS
UM-UC-3 M4X3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Hu[2lEPTB;M{[uPFY4PSEQvF2= MYPTRW5ITVJ?
DV-90 NFPIe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTN4LkmwOlch|ryP NH7LSpJUSU6JRWK=
ES8 MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKwS3hKSzVyPUO2Mlk{OThizszN NX61WIRZW0GQR1XS
YAPC NIHBUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDQTWM2OD1|Nj65OlU1KM7:TR?= NEnGcmJUSU6JRWK=
HCC1599 NFvkXYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rQb2lEPTB;M{euNVYyQCEQvF2= MmjhV2FPT0WU
UMC-11 M3Gzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXMTWM2OD1|Nz6yOVA{KM7:TR?= NV;Lb3dXW0GQR1XS
THP-1 M2G2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;ofopKSzVyPUO3MlI5PjhizszN MnzOV2FPT0WU
OCUB-M Ml\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELoTINKSzVyPUO3MlI5QTFizszN M1XGUnNCVkeHUh?=
NCI-H1693 M2S2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfucZZ{UUN3ME2zO{4{OjN|IN88US=> MnHBV2FPT0WU
NCI-H345 NWfOZmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHxSlZ3UUN3ME2zO{4{PjJ2IN88US=> MkW1V2FPT0WU
COLO-800 M3mxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH1TWM2OD1|Nz61Olch|ryP MmnBV2FPT0WU
COLO-320-HSR Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD1V5YyUUN3ME2zPE4{PDl{IN88US=> NH3LPXhUSU6JRWK=
NCI-H596 NW\lVpRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe5TWM2OD1|OD60OFg6KM7:TR?= NXLFd3B4W0GQR1XS
NCI-H187 M2jiOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33sZWlEPTB;M{iuO|M1PCEQvF2= MkPxV2FPT0WU
ECC4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN7LkC4NVQh|ryP M3LUXHNCVkeHUh?=
KP-4 NVXHU3VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DjXmlEPTB;M{muNVI{PSEQvF2= MVnTRW5ITVJ?
NCI-H2227 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTWcHZ7UUN3ME2zPU4{QTR7IN88US=> M2iyd3NCVkeHUh?=
22RV1 NFP4ZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTrN5ZFUUN3ME2zPU45Ozl6IN88US=> MnLxV2FPT0WU
SAS MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjLTWM2OD12MD6wPVYh|ryP Mnf1V2FPT0WU
PANC-10-05 NYfYT5VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvSS3R4UUN3ME20NE4yQDJ6IN88US=> MmrNV2FPT0WU
MDA-MB-468 MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LMUGlEPTB;NECuOVM1PiEQvF2= MnLmV2FPT0WU
RPMI-7951 Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTRzLkKwO|Uh|ryP MnvsV2FPT0WU
BB49-HNC MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvqdFVKSzVyPUSxMlIyPzlizszN MWXTRW5ITVJ?
23132-87 M2D3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;SOmlEPTB;NEGuNlc{OiEQvF2= NY[xc3lMW0GQR1XS
HCC1569 NXfkfG1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoH4TWM2OD12MT6yPFg2KM7:TR?= NXy2V41VW0GQR1XS
CP66-MEL M3GwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrZNHNKSzVyPUSyMlE5QDZizszN Mn3YV2FPT0WU
K-562 NIq2S4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LIVmlEPTB;NEKuNlg2PCEQvF2= NVn4TXJZW0GQR1XS
OCI-AML2 M4XKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm2TWM2OD12Mj64PVc1KM7:TR?= NVjNdJpmW0GQR1XS
SW756 NYLTN4RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEThe4tKSzVyPUSzMlA{QDhizszN Ml7JV2FPT0WU
M14 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj3TWM2OD12Mz6zNVg6KM7:TR?= MnrHV2FPT0WU
NCI-H1623 M2Sxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfXRZJKSzVyPUSzMlQ3PCEQvF2= NFrlO3dUSU6JRWK=
KNS-81-FD NUfB[YlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDVOoNKSzVyPUSzMlc3OiEQvF2= NFixS2dUSU6JRWK=
TGBC1TKB NUDVSGFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTR|LkmwPVkh|ryP NWrrWHptW0GQR1XS
RERF-LC-MS NHnwR3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXrWYNKSzVyPUSzMlkzQDFizszN M3;KXXNCVkeHUh?=
PC-3 M4jDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHDcIZKSzVyPUS0MlQ{PDdizszN NYjuemZ5W0GQR1XS
HuP-T4 M4fGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHHZoxmUUN3ME20OE41PDd2IN88US=> MXrTRW5ITVJ?
NCI-H510A MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHCTWM2OD12ND63NFgh|ryP MUDTRW5ITVJ?
LB2518-MEL NUXQXWx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnUe5FKSzVyPUS0Mlc6OzdizszN MUfTRW5ITVJ?
TE-5 NWXO[YlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrGbZFKSzVyPUS1Mlk2QDFizszN MWfTRW5ITVJ?
EW-24 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDRTWM2OD12Nj6xO|I{KM7:TR?= NFPmVm1USU6JRWK=
LB647-SCLC M1H2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXjZpM5UUN3ME20Ok4zOTV3IN88US=> M1zzTnNCVkeHUh?=
NCI-H524 MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHGNVBKSzVyPUS2MlcyQDVizszN MWDTRW5ITVJ?
EW-11 NGPx[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR4LkmzO|Mh|ryP MWDTRW5ITVJ?
KALS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HXXGlEPTB;NEeuNlA3PiEQvF2= MoXFV2FPT0WU
BT-474 NXTDb2ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUWxR|BkUUN3ME20O{41OjF4IN88US=> NEXZZ3dUSU6JRWK=
SK-N-AS M4DuRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T3VWlEPTB;NEeuPFg5KM7:TR?= NUHBVXJFW0GQR1XS
HCC2157 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLWeG1qUUN3ME20PE4xPzZizszN MXHTRW5ITVJ?
HCC1954 NUjjW3d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTR6LkG3NFQh|ryP NVPo[3pKW0GQR1XS
FADU Mk\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX1bmpVUUN3ME20PE4{ODNzIN88US=> M2jTUHNCVkeHUh?=
S-117 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\KVmlEPTB;NEiuN|gyPSEQvF2= NGHFXYJUSU6JRWK=
LS-1034 M4f6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR6LkewOlch|ryP MXfTRW5ITVJ?
CAMA-1 NWC2UJlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLUTWM2OD12OT61OVQ{KM7:TR?= M17rb3NCVkeHUh?=
LU-134-A NHrvcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HPZmlEPTB;NEmuPFA5PSEQvF2= NHj1WnJUSU6JRWK=
NCI-H1838 NX7XOXJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrkTWM2OD12OT64NFg4KM7:TR?= MU\TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
+ Expand

Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
+ Expand
  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709017 Recruiting Chronic Myeloid Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Korea Otsuka Pharmaceutical Co. Ltd. October 2018 --
NCT03690115 Not yet recruiting Leukemia Myeloid Acute Versailles Hospital October 2018 Phase 2
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03589326 Recruiting Lymphoblastic Leukemia Acute Adult|Acute Lymphoid Leukemia|Leukemia Acute Lymphoblastic|Leukemia Lymphoblastic|Ph1 Chromosome|Leukemia Lymphoblastic Acute Philadelphia-Positive Millennium Pharmaceuticals Inc.|Takeda August 10 2018 Phase 3
NCT03576547 Recruiting Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|t(9;22) M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 26 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID