Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Cited by 31 Publications

6 Customer Reviews

  • Immunoblot of H23 cells treated with trametinib (25 nM), ponatinib (750 nM), or their combination for the times shown.

    Nature, 2016, 534(7609):647-51. Ponatinib (AP24534) purchased from Selleck.

     

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

  • Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

    The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

  • Western blot analysis of lysates of Ba/F3 cells expressing BCR/ABL and BCR/ABL-T315I using antibodies directed against: c-ABL, ABL-Y245 (anti-phospho-ABL), Crkl, phosphorylated Crkl, STAT5, phosphorylated STAT5 (anti-phospho-STAT5) and β-tubulin (anti-β-tubulin). Molecular mass references (kDa) are presented, and c-ABL and β-Tubulin were used as a loading control.

    Leukemia, 2015, 29(5):1104-14. Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NVjUSGJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4riTmlEPTB;MD6wNFAxODByM{W5JO69VQ>? NYe2dJNvW0GQR1XS
MV-4-11 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DoPWlEPTB;MD6wNFAxQTV4IN88US=> MmfYV2FPT0WU
MEG-01 NFSwZ4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki3TWM2OD1yLkCwNFEzQCEQvF2= NGHWeW5USU6JRWK=
LAMA-84 M4P3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m1cGlEPTB;MD6wNFAyPjVizszN MmnlV2FPT0WU
CGTH-W-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMECxOlkh|ryP M{TOdHNCVkeHUh?=
KASUMI-1 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\nSGxsUUN3ME2wMlAxOjF5IN88US=> MkTDV2FPT0WU
BE-13 M3XzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrDNIJKSzVyPUCuNFAzPTlizszN NIPLZ5RUSU6JRWK=
CTV-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHwUI5PUUN3ME2wMlAxPTJzIN88US=> MWPTRW5ITVJ?
NKM-1 NIPrSGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn5O4dKSzVyPUCuNFA3PTVizszN NFvMTG5USU6JRWK=
MONO-MAC-6 NUn4OYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7IOoNKSzVyPUCuNFA5OzdizszN NHTqOIVUSU6JRWK=
A204 M{D6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHuTWM2OD1yLkCxNlE5KM7:TR?= M1PlVnNCVkeHUh?=
GDM-1 NVXrc5NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rkdWlEPTB;MD6wNVg{OyEQvF2= MormV2FPT0WU
AN3-CA NHXldXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLnTWM2OD1yLkCxPFc{KM7:TR?= M4rhWnNCVkeHUh?=
BL-70 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon3TWM2OD1yLkCyNVk6KM7:TR?= NU\ifIV4W0GQR1XS
Daudi Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnrNYZJUUN3ME2wMlAzPTN5IN88US=> M1zmVXNCVkeHUh?=
KU812 NEnw[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrWSFJwUUN3ME2wMlAzQDR6IN88US=> MmG4V2FPT0WU
KG-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13ZOmlEPTB;MD6wN|I6PCEQvF2= NGDne5dUSU6JRWK=
DOHH-2 NWjZbXE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnYOmlKSzVyPUCuNFQ5ODNizszN M2r6cXNCVkeHUh?=
HuO9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELqbpVKSzVyPUCuNFU1PDhizszN MWHTRW5ITVJ?
EB2 MmjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLzWIRtUUN3ME2wMlA2PTd4IN88US=> MlPQV2FPT0WU
G-402 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLQTlJKSzVyPUCuNFY{PDFizszN MlLrV2FPT0WU
SU-DHL-1 NXL4fIdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33ZRmlEPTB;MD6wOlM4QSEQvF2= MYrTRW5ITVJ?
NCI-H719 NWXrdmdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDGO2FKSzVyPUCuNFc5QDhizszN NXP1SWd4W0GQR1XS
MLMA MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEmwOkDPxE1? NVzLd|BNW0GQR1XS
KM12 M2jX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XnN2lEPTB;MD6wPVc{PyEQvF2= MlHNV2FPT0WU
SUP-T1 NV3ZPIVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXZZWtKSzVyPUCuNFk6QDJizszN NInTdpFUSU6JRWK=
MZ1-PC M17ITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMUGzN|Yh|ryP MV3TRW5ITVJ?
MFE-296 NVTOZmh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnuTWM2OD1yLkGxPFM6KM7:TR?= NIrP[INUSU6JRWK=
ALL-PO M1z3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn2bWhKSzVyPUCuNVI1PDNizszN MXTTRW5ITVJ?
GB-1 M3rYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1izUmlEPTB;MD6xNlUyOiEQvF2= M4LjUnNCVkeHUh?=
SIG-M5 NGHmWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LzSmlEPTB;MD6xN|M4KM7:TR?= NF;ZNXRUSU6JRWK=
P30-OHK MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC2RmZ{UUN3ME2wMlE2Pjd{IN88US=> NV7rTZZWW0GQR1XS
NCI-H716 NF2yT3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrrNGpKSzVyPUCuNVYzPjZizszN MlHYV2FPT0WU
MPP-89 MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMU[5N|Mh|ryP M1S5S3NCVkeHUh?=
SF126 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHmO5hVUUN3ME2wMlE4ODZ|IN88US=> NHPNfHlUSU6JRWK=
CTB-1 M4\qRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliyTWM2OD1yLkG3N|E3KM7:TR?= MWHTRW5ITVJ?
CA46 NVjuZ3RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf1PWVnUUN3ME2wMlE4PDh7IN88US=> NUi0fHNSW0GQR1XS
NCI-H520 MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD6R|ZIUUN3ME2wMlE4PzN{IN88US=> Mlj3V2FPT0WU
CAL-85-1 NV7MUVBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HXdmlEPTB;MD6xO|kzPyEQvF2= NX\ld2dLW0GQR1XS
NCI-H2342 NFzn[oJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUi1O|ch|ryP MWrTRW5ITVJ?
697 NHG3bFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkG2TWM2OD1yLkG4PFcyKM7:TR?= MXXTRW5ITVJ?
NY M1[4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXFTWM2OD1yLkG5Nlg4KM7:TR?= NEXEOW9USU6JRWK=
T98G NYiyRnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUmzNVgh|ryP M2f1[nNCVkeHUh?=
NCI-H1703 MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TSemlEPTB;MD6xPVYyPSEQvF2= MnHmV2FPT0WU
NCI-H2087 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLrUW1KSzVyPUCuNlA1OzlizszN MVXTRW5ITVJ?
PF-382 M1vPbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGThcHBKSzVyPUCuNlA5PzNizszN M3q1cXNCVkeHUh?=
HCT-116 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMkGwOlkh|ryP MYLTRW5ITVJ?
CAKI-1 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMkG2OlYh|ryP NUDzdIlXW0GQR1XS
CCF-STTG1 NYnDPXJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMkK0O|Uh|ryP MXLTRW5ITVJ?
D-392MG NWPuN3lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMkOxO|ch|ryP NVy5OYV2W0GQR1XS
RT-112 NG\INmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF76VJpKSzVyPUCuNlM4QTVizszN Mk\GV2FPT0WU
MES-SA NEjoUFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XNd2lEPTB;MD6yOFE5PyEQvF2= MmrHV2FPT0WU
LC-2-ad NXfldXVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf4U4M5UUN3ME2wMlI1OjZ3IN88US=> NYLCN2NOW0GQR1XS
NOS-1 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf3Vm9OUUN3ME2wMlI1OzZ5IN88US=> Ml\vV2FPT0WU
NALM-6 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\RO4lKSzVyPUCuNlU2PDNizszN M2Ln[nNCVkeHUh?=
TE-15 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMk[wPVEh|ryP MYPTRW5ITVJ?
786-0 M2nsb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[xd2lEPTB;MD6yOlIzQCEQvF2= NYXFOYg1W0GQR1XS
IST-MES1 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DpXmlEPTB;MD6yOlgzQSEQvF2= M2LEeXNCVkeHUh?=
KYSE-180 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rD[2lEPTB;MD6yOlg6OSEQvF2= NWCyeJBTW0GQR1XS
YT MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i2[GlEPTB;MD6yOlk4PCEQvF2= NIfqW49USU6JRWK=
A427 NXrsfIx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGniTGFKSzVyPUCuNlczPjRizszN NHjtPZlUSU6JRWK=
KYSE-450 NGPVcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfub3FNUUN3ME2wMlI4OzJ7IN88US=> M33RUnNCVkeHUh?=
HuH-7 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMke3OlMh|ryP MY\TRW5ITVJ?
CAS-1 NWHwfIVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMkizNFMh|ryP MmT4V2FPT0WU
KURAMOCHI M1vBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\JTWM2OD1yLkK4OFE6KM7:TR?= NFjMR5pUSU6JRWK=
ACHN M4DZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HkWmlEPTB;MD6yPVMzOyEQvF2= NVvlO2RXW0GQR1XS
HGC-27 NWLJfJJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMkmzOVMh|ryP M2XBTHNCVkeHUh?=
A172 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMkm1O|ch|ryP M3yxTnNCVkeHUh?=
SNU-449 NFzrNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fSXWlEPTB;MD6yPVk3PCEQvF2= Mo\NV2FPT0WU
SW982 M4PvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf2N2tKSzVyPUCuNlk6PzhizszN MlfkV2FPT0WU
EFO-21 M{XsSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\lfZhKSzVyPUCuN|A1OTFizszN M4PDNnNCVkeHUh?=
NCI-H2030 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwM{GxOlQh|ryP M3\XcHNCVkeHUh?=
HT-144 NGnOUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\Vd2lEPTB;MD6zNVI5KM7:TR?= NXP2RpF5W0GQR1XS
MFE-280 M2XNe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnIR4FKSzVyPUCuN|E1PTNizszN NGLIdYRUSU6JRWK=
SK-LU-1 Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwM{G0OlYh|ryP MWjTRW5ITVJ?
NCI-H2052 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrVTWM2OD1yLkOxOFg1KM7:TR?= NGTDOZJUSU6JRWK=
SK-HEP-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe3SndDUUN3ME2wMlM{OzZ6IN88US=> NFHtW4dUSU6JRWK=
QIMR-WIL NI\yRohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XLTGlEPTB;MD6zN|QzPCEQvF2= M2LNVnNCVkeHUh?=
A2780 M2\pbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjvR|BKSzVyPUCuN|Q{ODRizszN MYLTRW5ITVJ?
ACN M4\oSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwM{S4O|Mh|ryP MUfTRW5ITVJ?
BxPC-3 NYrOXJRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jud2lEPTB;MD6zOFk5QSEQvF2= NEHo[2ZUSU6JRWK=
BCPAP M{LPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH62ZmtKSzVyPUCuN|YxODFizszN MVvTRW5ITVJ?
HOP-62 M3vhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG0bIVKSzVyPUCuN|YyODZizszN NU\Yb2RtW0GQR1XS
SW1710 NW\vR5N2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HoOmlEPTB;MD6zOlQ2PSEQvF2= MoDuV2FPT0WU
OPM-2 MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S4UWlEPTB;MD6zOlQ4OyEQvF2= M1XvSXNCVkeHUh?=
DBTRG-05MG Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3MWGZEUUN3ME2wMlM5ODV2IN88US=> NWj0fmk6W0GQR1XS
SK-MEL-24 M1XlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TvNGlEPTB;MD6zPVc6OSEQvF2= M4PPeHNCVkeHUh?=
8305C MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDkTWM2OD1yLkO5O|k{KM7:TR?= NVTqT4F1W0GQR1XS
OVCAR-4 M2rNSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwNEG1PFYh|ryP NYrKeIZPW0GQR1XS
HLE NVviRXpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLvSpdJUUN3ME2wMlQyQDZizszN NXnWb4V5W0GQR1XS
NCI-H747 MnHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\ZTWM2OD1yLkSyNVM4KM7:TR?= MnG2V2FPT0WU
SW780 Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf5R2JKSzVyPUCuOFI{PDZizszN NX64[oh2W0GQR1XS
KYSE-150 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwNEK0NVUh|ryP NVSzZ3R6W0GQR1XS
H4 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPPNoF3UUN3ME2wMlQzPDVzIN88US=> MkH5V2FPT0WU
SW1088 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PIcWlEPTB;MD60OFM6KM7:TR?= MkDPV2FPT0WU
SF268 NV60PW1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP5fVBkUUN3ME2wMlQ1QDZizszN NELifI5USU6JRWK=
RT4 NHv5SndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPmZ4VWUUN3ME2wMlQ2OTFzIN88US=> NW\QRmo6W0GQR1XS
NCI-H522 NXjJXGpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV6zXnV[UUN3ME2wMlQ2OjdizszN M1nwWHNCVkeHUh?=
LCLC-97TM1 NXi2Rnc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jydGlEPTB;MD60OlE6PSEQvF2= MkPBV2FPT0WU
CAL-39 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjlW5RvUUN3ME2wMlQ3PTF7IN88US=> M3HGSHNCVkeHUh?=
CAL-120 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3ucGtKSzVyPUCuOFc3PDNizszN NHzO[XFUSU6JRWK=
ESS-1 M1;ITWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml23TWM2OD1yLkS3PFIyKM7:TR?= M4XMNXNCVkeHUh?=
KARPAS-45 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T4VWlEPTB;MD60PFk{OyEQvF2= MXPTRW5ITVJ?
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SK-NEP-1 NV\iUWxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTFwOEO3Olch|ryP NYXpcWdpW0GQR1XS
D-542MG NULTcWpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjDRm9PUUN3ME2xMlg2QDVzIN88US=> NWLteWs4W0GQR1XS
KNS-42 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDM[IV6UUN3ME2xMlg3OjZ4IN88US=> NXL3No1LW0GQR1XS
NCI-H2452 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD5TVlDUUN3ME2xMlg6ODd2IN88US=> MnrvV2FPT0WU
SK-MEL-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwOUCyO|Eh|ryP MnTVV2FPT0WU
OVCAR-5 NETUOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfsTWM2OD1zLkmwOlc2KM7:TR?= NHriSXBUSU6JRWK=
SNG-M MmXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zHcGlEPTB;MT65OVg2QCEQvF2= MoDmV2FPT0WU
A673 M2mycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n6TmlEPTB;MT65O|UyPiEQvF2= NGLtfpNUSU6JRWK=
L-428 M1zYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj0TWM2OD1zLkm5NVc6KM7:TR?= NYSzVWRvW0GQR1XS
KM-H2 M1zmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jaO2lEPTB;Mj6wNVA6KM7:TR?= NInVNXFUSU6JRWK=
MC-IXC NVjKNXVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTJwMEKyO|Mh|ryP NULSVnZxW0GQR1XS
COLO-678 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrmcWxsUUN3ME2yMlA1OjB5IN88US=> NHLwPYtUSU6JRWK=
MEL-JUSO MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTETWM2OD1{LkC3PFUyKM7:TR?= NH7CfHlUSU6JRWK=
HCC38 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zPNGlEPTB;Mj6wPFQ{OyEQvF2= M4DzO3NCVkeHUh?=
UACC-62 M4X3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ixVGlEPTB;Mj6wPFg2PSEQvF2= MoDmV2FPT0WU
OAW-42 NYi0cHVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnXZ5RXUUN3ME2yMlA6PzFzIN88US=> M{DJO3NCVkeHUh?=
LB996-RCC M{D2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUftfpAzUUN3ME2yMlE{QDF5IN88US=> M3vhfXNCVkeHUh?=
COR-L105 M3XGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;OTWM2OD1{LkG2N|c{KM7:TR?= NHixPWdUSU6JRWK=
RCC10RGB MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwMUi1O|Yh|ryP M2LiXHNCVkeHUh?=
A431 NIfk[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfTTWM2OD1{LkG5NFE6KM7:TR?= MmrTV2FPT0WU
NCI-H292 M1L5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XibGlEPTB;Mj6yN|k2OSEQvF2= MoHzV2FPT0WU
SK-UT-1 NEP3c5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vDR2lEPTB;Mj6zN|E5PCEQvF2= NYf5W2xoW0GQR1XS
PANC-08-13 Ml\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fUZWlEPTB;Mj6zN|I{PSEQvF2= M2rxVXNCVkeHUh?=
ST486 MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f5NGlEPTB;Mj60NVA1QCEQvF2= M3SwfHNCVkeHUh?=
SJSA-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLETWM2OD1{LkSxNlcyKM7:TR?= NFr1PINUSU6JRWK=
RKO M{O4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jPTmlEPTB;Mj60NlAzQSEQvF2= MU\TRW5ITVJ?
NCI-H1793 NUe3dXlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P5cGlEPTB;Mj60OFAzQSEQvF2= NFzXb5hUSU6JRWK=
639-V MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGS2NXZKSzVyPUKuOFU{QDJizszN NWnEU5QxW0GQR1XS
ES3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjnTWM2OD1{LkS5O|M4KM7:TR?= MVzTRW5ITVJ?
NCI-H1792 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfXWWZKSzVyPUKuOVY5OjZizszN M{TQOnNCVkeHUh?=
NCI-H1651 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnIfZA3UUN3ME2yMlU5OjFizszN MV7TRW5ITVJ?
SN12C NGfaUpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCwb3lKSzVyPUKuOVg1QDdizszN MofYV2FPT0WU
COLO-679 NVWw[lZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4i0RWlEPTB;Mj61PFYxPSEQvF2= M4DVcXNCVkeHUh?=
U-118-MG M2TkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJwNUi4O|Ih|ryP NUHEbYptW0GQR1XS
Ramos-2G6-4C10 M1K0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK3Tm9qUUN3ME2yMlY1QDB5IN88US=> MWPTRW5ITVJ?
HCT-15 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn3TWM2OD1{Lk[4O|kzKM7:TR?= NVj6[|RWW0GQR1XS
MDA-MB-157 NXr6WVBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWToOmtVUUN3ME2yMlcxPzR5IN88US=> Mm\ZV2FPT0WU
K5 NHvnTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjrTWM2OD1{LkexPFQ2KM7:TR?= M2DvOnNCVkeHUh?=
MKN45 NH;neZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrITWM2OD1{LkezN|Y3KM7:TR?= NIHye5pUSU6JRWK=
DMS-273 MlvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjXOWpKSzVyPUKuO|U3OzJizszN MoPtV2FPT0WU
C8166 NGj6Oo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJwN{i1NVMh|ryP MmfXV2FPT0WU
Calu-3 NH3LOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJwN{i5Olkh|ryP M1jLVXNCVkeHUh?=
SNB75 NHLGRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXWfmRvUUN3ME2yMlg5PTN3IN88US=> MV3TRW5ITVJ?
BFTC-905 NWLweXEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETDRY5KSzVyPUKuPVAyQTFizszN NUSwbIE6W0GQR1XS
C-4-II NWnoO2JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XwO2lEPTB;Mj65NVM2OyEQvF2= NIL3XJBUSU6JRWK=
MS-1 NFv0b2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ZfmlEPTB;Mj65Olc3QSEQvF2= NE\3epVUSU6JRWK=
A375 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLTTWM2OD1|LkC4NVg1KM7:TR?= NV63XmZnW0GQR1XS
KYSE-70 M3\uN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTNwMEi4PFIh|ryP MoDJV2FPT0WU
KYSE-510 NX;FTG91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\6NWFKSzVyPUOuNVA6QTVizszN M3zrNnNCVkeHUh?=
LN-405 NXrrN|hIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HtSWlEPTB;Mz6xN|UyQCEQvF2= MYnTRW5ITVJ?
BOKU NVzV[IxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LqPWlEPTB;Mz6xOFI2PiEQvF2= MnvXV2FPT0WU
TE-10 MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjUTWM2OD1|LkG3N|YzKM7:TR?= M2[3[nNCVkeHUh?=
MKN1 NIXXc2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwMUi0PFMh|ryP NHjBS4VUSU6JRWK=
M059J MlnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn5e3Y4UUN3ME2zMlIxOTd|IN88US=> MVXTRW5ITVJ?
GOTO MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTNwMkKwN|kh|ryP M3O2b3NCVkeHUh?=
DK-MG NFfa[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfFUG1KSzVyPUOuNlU6PzZizszN M3;k[XNCVkeHUh?=
NCI-H727 NH7KeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HjWWlEPTB;Mz6yOlU5KM7:TR?= M2K3fHNCVkeHUh?=
NB12 NWO0UY14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljkTWM2OD1|LkOzNlI1KM7:TR?= NVSz[nJPW0GQR1XS
DOK NFXx[GZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTNwM{[xPFYh|ryP M{f1OHNCVkeHUh?=
KYSE-410 NEfNbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTNwM{[yPFch|ryP MkLyV2FPT0WU
AM-38 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\MOW1EUUN3ME2zMlM5ODVzIN88US=> NWX3PXhbW0GQR1XS
GR-ST NH3NSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\JZYFKSzVyPUOuOFU4OzJizszN NUnpWGJRW0GQR1XS
D-247MG Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHraT2ZKSzVyPUOuOFgzPjNizszN MmjGV2FPT0WU
TE-8 NVHmNJlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDTTWM2OD1|LkS5N|M{KM7:TR?= NUOzeZB6W0GQR1XS
LS-411N M13Ie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTNwNEm2PVIh|ryP M1ixUnNCVkeHUh?=
SK-MES-1 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrBdnRKSzVyPUOuOVY1OzNizszN Mon1V2FPT0WU
SF295 NYD6d|k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTVbXVKSzVyPUOuOlE2PTJizszN M{nQXnNCVkeHUh?=
SK-MEL-30 M{TsR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwNkW5NlEh|ryP MYHTRW5ITVJ?
LB2241-RCC NYHJS4k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr5flZuUUN3ME2zMlY3OjZizszN NXPyXYkyW0GQR1XS
PC-14 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrQV4Q4UUN3ME2zMlY3PDN5IN88US=> M4\5UHNCVkeHUh?=
EW-7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTNwNke2PVMh|ryP NGjZcpRUSU6JRWK=
NMC-G1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nJUGlEPTB;Mz63NVg{PyEQvF2= NULkV4p6W0GQR1XS
TE-441-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrG[3FKSzVyPUOuO|MxOjhizszN NILlWY1USU6JRWK=
NCI-H1618 M2TqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrLdm5zUUN3ME2zMlgyQDd3IN88US=> NXjSOGt4W0GQR1XS
PANC-03-27 NFz5ZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXlbGlKSzVyPUOuPFE6OTZizszN MnfuV2FPT0WU
NCI-H2228 NXLJeodzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHON|diUUN3ME2zMlg{OTJ4IN88US=> MVjTRW5ITVJ?
CAPAN-1 M2LyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mz[mlEPTB;Mz64O|AxQSEQvF2= NX3jdIJKW0GQR1XS
KLE M3nHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[zbIVKSzVyPUOuPVA3PyEQvF2= NHf2R4ZUSU6JRWK=
Becker M1;scmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW0TWM2OD1|LkmyPFQ6KM7:TR?= NXzrTmZwW0GQR1XS
SK-PN-DW NELlU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXP2XGI6UUN3ME20MlA4QTd2IN88US=> MWLTRW5ITVJ?
Hs-578-T M4Hib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInFbYpKSzVyPUSuNFg{ODZizszN MkP6V2FPT0WU
RS4-11 NUHIV4txT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W0e2lEPTB;ND6xNVI2PSEQvF2= MV3TRW5ITVJ?
D-502MG NYXXVYxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTRwMU[5PVch|ryP NWXGbnVyW0GQR1XS
GI-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTBTWM2OD12LkK4Nlk6KM7:TR?= NFLwenRUSU6JRWK=
NCI-H209 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\PUFNKSzVyPUSuN|M4QCEQvF2= NFnIRVBUSU6JRWK=
SK-OV-3 M1;KbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DpfGlEPTB;ND60PFE1QSEQvF2= M{jQV3NCVkeHUh?=
LOUCY NEKxcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vzSmlEPTB;ND60PFQ{OiEQvF2= MnfFV2FPT0WU
NCI-H69 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTzb|ZKSzVyPUSuOVE4QTNizszN MVTTRW5ITVJ?
SCC-9 NEO3[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn3XZFXUUN3ME20MlU{OTd{IN88US=> NG\2VXRUSU6JRWK=
NCI-H526 M3rmdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTRwNUmyPVMh|ryP M2rKOHNCVkeHUh?=
NCI-H2170 NFPyTplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\TTWM2OD12Lk[2O|cyKM7:TR?= NV;VO49zW0GQR1XS
SR MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu0UZZKSzVyPUSuO|AxPDhizszN M1T6NXNCVkeHUh?=
CMK NGezWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXveZhuUUN3ME20MlczOTBzIN88US=> MnP6V2FPT0WU
COLO-829 NIfqUlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTRwN{ewOFMh|ryP NVz0dZptW0GQR1XS
HuO-3N1 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTyNo5SUUN3ME20Mlg{OjhzIN88US=> NUPqSZFTW0GQR1XS
5637 NEHVe4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnqTWM2OD12LkmwOFg4KM7:TR?= MlrpV2FPT0WU
A253 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPEbllKSzVyPUSuPVc4ODhizszN MVzTRW5ITVJ?
NB10 NFnJWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTVwMEe0PVch|ryP NUnqWWdxW0GQR1XS
SF539 NUDxbVJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP0TWM2OD13LkC5PVU6KM7:TR?= NH;IV2pUSU6JRWK=
HAL-01 NXK3WoxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHUcldKSzVyPUWuNVQ3PDVizszN MmHmV2FPT0WU
MHH-ES-1 NVy5b4lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTVwMU[5NlUh|ryP MW\TRW5ITVJ?
DEL NUXsZZg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYH0[VkxUUN3ME21MlI4PTh{IN88US=> NXnNfWRJW0GQR1XS
NCI-H1299 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HtbmlEPTB;NT6zOVAxPyEQvF2= M2K1UnNCVkeHUh?=
ChaGo-K-1 NFjjdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfoeWZjUUN3ME21MlM2OTB5IN88US=> NGX0[lJUSU6JRWK=
HMV-II M176e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[2bY5HUUN3ME21MlM6PDNizszN NYXyPHhvW0GQR1XS
NB69 NUnNc3U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTvXlVbUUN3ME21MlM6PjNzIN88US=> M2jXfXNCVkeHUh?=
NCI-H1882 NXzvZlVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37CVGlEPTB;NT60N|M3PCEQvF2= MnT3V2FPT0WU
SNU-475 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfFRYdKSzVyPUWuOFcyPzFizszN MUPTRW5ITVJ?
RXF393 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTVwNEi0PVQh|ryP Mn7yV2FPT0WU
CAL-51 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPGTWM2OD13Lk[yPFU{KM7:TR?= NUPKeo1qW0GQR1XS
SW1573 M2HSfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDRfWFQUUN3ME21MlY{PTN2IN88US=> MlzmV2FPT0WU
GCT MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTVwN{W5Nlkh|ryP MUXTRW5ITVJ?
COR-L88 NIW2WoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzrTWM2OD13Lke2PFQ3KM7:TR?= MWXTRW5ITVJ?
MDA-MB-134-VI Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVwOEe1N|Yh|ryP MVnTRW5ITVJ?
NB5 NXz2bmtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fOXGlEPTB;NT65NlQ1KM7:TR?= M1zYNnNCVkeHUh?=
GMS-10 NUK5Z|Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PocWlEPTB;NT65Olg3OSEQvF2= MWnTRW5ITVJ?
CHP-212 M4PkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjSTWM2OD14LkS4NlY4KM7:TR?= M1TpVXNCVkeHUh?=
TE-11 NFvLOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G3bmlEPTB;Nj61OVE5OiEQvF2= NF3zXFVUSU6JRWK=
SW962 Mni3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj1TWM2OD14Lk[1O|c1KM7:TR?= NH\Q[G5USU6JRWK=
MZ2-MEL NEftOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPZ[2ZKSzVyPU[uPFIxOTFizszN Mn;MV2FPT0WU
C-33-A MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTZwOUG2PFgh|ryP NXnwNGZ1W0GQR1XS
IGR-1 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTZwOUe4NlYh|ryP NYG4RnhKW0GQR1XS
MOLT-4 NY\VXVlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFL5N|lKSzVyPUeuNVU1ODZizszN NWTDdppRW0GQR1XS
NCI-H1650 M33vXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTdwMkewOFYh|ryP Mn\TV2FPT0WU
AsPC-1 NXj1XmxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TWcmlEPTB;Nz6yPFYxPSEQvF2= NGLwcHZUSU6JRWK=
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KU-19-19 M1HI[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTtdWVKSzVyPUKxMlg6QDJizszN NWfQfJJQW0GQR1XS
T84 NVzKeHE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJzLkm4NVkh|ryP M{HjfHNCVkeHUh?=
NCI-H630 NVfQOJJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3iz[WlEPTB;MkKuOVM3OyEQvF2= MXvTRW5ITVJ?
LU-165 NXTYcZEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zlOWlEPTB;MkKuOVU1KM7:TR?= NIX0TnFUSU6JRWK=
COLO-792 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjX[JZKSzVyPUKyMlcyOTFizszN MlP6V2FPT0WU
CAL-62 NWTHbVNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzjZ3RKSzVyPUKyMlc2OTdizszN NFXy[JpUSU6JRWK=
HCE-T NXnIfo01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\zcGlEPTB;MkKuPFYxPiEQvF2= MVzTRW5ITVJ?
BB65-RCC NH71R4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[xVWlEPTB;MkOuNFM1PCEQvF2= MYHTRW5ITVJ?
SiHa MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jROGlEPTB;MkOuN|k3QCEQvF2= MVXTRW5ITVJ?
NCI-H2081 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTlO|dLUUN3ME2yOE4xPjRzIN88US=> NWn6d2k3W0GQR1XS
U251 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonlTWM2OD1{ND6wOlY5KM7:TR?= Ml33V2FPT0WU
LoVo MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf1TWM2OD1{ND65NlgzKM7:TR?= MlfXV2FPT0WU
GCIY M2iycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LpVmlEPTB;MkWuNlg4PyEQvF2= NFLI[YpUSU6JRWK=
NUGC-3 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnKTWM2OD1{NT6zN|E3KM7:TR?= NFLQU5dUSU6JRWK=
LNCaP-Clone-FGC MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofPTWM2OD1{NT6zOFk5KM7:TR?= NUjJZmlpW0GQR1XS
PA-1 NXHlUmg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TSS2lEPTB;MkWuOlg{OyEQvF2= NFPZdJRUSU6JRWK=
OE33 NEnINotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TU[WlEPTB;MkWuOlg2OyEQvF2= MlvpV2FPT0WU
HT-29 NVu0S|MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjifo12UUN3ME2yOU44QDd7IN88US=> NWfXUZR{W0GQR1XS
RCM-1 NXrIOndtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7FVXkyUUN3ME2yOU46PjV4IN88US=> NY\mSFAzW0GQR1XS
NCI-H1522 NXvC[Vk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ3Lkm5NVEh|ryP NIr4NJJUSU6JRWK=
LB373-MEL-D MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELNNpdKSzVyPUK2MlE4ODhizszN MYHTRW5ITVJ?
NCI-H1436 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TCR2lEPTB;Mk[uNlc{QCEQvF2= MnXvV2FPT0WU
COLO-824 NW\4RlVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJ4LkSwNFIh|ryP MWfTRW5ITVJ?
CP50-MEL-B MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7iXYZEUUN3ME2yOk42Pjd3IN88US=> M{\VV3NCVkeHUh?=
EGI-1 NGLpcJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfFZ41nUUN3ME2yO{4zPjl6IN88US=> NIDRS2hUSU6JRWK=
LAN-6 NXrrNHVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPwZ5lKSzVyPUK3MlM2QThizszN MnTiV2FPT0WU
GAK M2L6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXvdJMzUUN3ME2yO{41OjJ3IN88US=> NUH1fWx6W0GQR1XS
MDA-MB-175-VII M3z5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHHTWM2OD1{Nz61NFU{KM7:TR?= NFrGToJUSU6JRWK=
JVM-2 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXvPZBKSzVyPUK3MlY3OjJizszN MWTTRW5ITVJ?
UACC-257 NH;hNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LiZmlEPTB;MkeuOlg4QCEQvF2= MVTTRW5ITVJ?
SW1783 NYTUdJJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XENWlEPTB;MkeuO|c5OyEQvF2= NWfZdoRRW0GQR1XS
HT-3 NF\rfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjXTWM2OD1{OD6yNVY3KM7:TR?= M4fDdHNCVkeHUh?=
RL M1roTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnzTWM2OD1{OD61PVEyKM7:TR?= NGnXZ|dUSU6JRWK=
TK10 NHXFeHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD6[WxTUUN3ME2yPE43PTN3IN88US=> M2fQdXNCVkeHUh?=
HT55 M{DGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jj[2lEPTB;MkmuNFU3PSEQvF2= NIq1T2hUSU6JRWK=
BT-20 NXmzbo9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\OZmlEPTB;MkmuNFU5PiEQvF2= NW\IPJpVW0GQR1XS
TGBC24TKB NGTsdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ7LkG4N|Eh|ryP M1fxenNCVkeHUh?=
HSC-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV24SIxYUUN3ME2yPU4{ODBzIN88US=> MlPXV2FPT0WU
COLO-205 NUKw[5dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ7LkO5OFQh|ryP MkjaV2FPT0WU
GT3TKB M2jOZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;SSmlEPTB;MkmuOlg4PyEQvF2= MVXTRW5ITVJ?
T47D NXvib4hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX62emJ1UUN3ME2yPU45PTh{IN88US=> M3L6e3NCVkeHUh?=
OMC-1 M4PoOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rEZ2lEPTB;M{CuNVkyQSEQvF2= NYLZXXVpW0GQR1XS
PFSK-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHETWM2OD1|MT6yOlU6KM7:TR?= NUfOSFJxW0GQR1XS
JEG-3 M{jUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DMcmlEPTB;M{GuN|U3OSEQvF2= NWj0RldsW0GQR1XS
RD M{HONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml65TWM2OD1|MT61NVE2KM7:TR?= MVLTRW5ITVJ?
NCI-H64 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrRVlNyUUN3ME2zNk41OTd7IN88US=> NUHqemw5W0GQR1XS
DMS-114 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;KVWlEPTB;M{KuOFE5OiEQvF2= M4LLUnNCVkeHUh?=
NCI-H661 Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLETWM2OD1|Mj62OVAyKM7:TR?= MYTTRW5ITVJ?
CAL-148 M2POdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\IO2lEPTB;M{KuOlY3PSEQvF2= MWTTRW5ITVJ?
HuP-T3 NFS3XoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Tt[mlEPTB;M{KuPVM{QCEQvF2= NUHtZZBJW0GQR1XS
ES4 NGLa[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTCcYpRUUN3ME2zN{4yPzB3IN88US=> MULTRW5ITVJ?
Ca9-22 NXnNRnVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK1TWM2OD1|Mz60OlAyKM7:TR?= Ml7IV2FPT0WU
LP-1 M4TMd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfQTGNLUUN3ME2zOE4xQSEQvF2= MXzTRW5ITVJ?
AU565 NXG2Z3RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDZTWM2OD1|ND61NFY6KM7:TR?= NIPSOlFUSU6JRWK=
MDA-MB-453 MkLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjveolKSzVyPUO1MlE1OjZizszN M1W1b3NCVkeHUh?=
SNU-C1 NETzNWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TaW2lEPTB;M{WuNVcyKM7:TR?= MmniV2FPT0WU
SW13 MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN3LkSwO|Yh|ryP MVTTRW5ITVJ?
NCI-H2122 M{PBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TYZ2lEPTB;M{WuOVU6QCEQvF2= NFfZTWFUSU6JRWK=
NCI-H1395 NWS5e2sxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTN3Lk[2PVEh|ryP NGLUOWlUSU6JRWK=
J-RT3-T3-5 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vDTmlEPTB;M{[uNFI6PCEQvF2= MYHTRW5ITVJ?
COR-L279 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTVN|dKSzVyPUO2MlE6QDFizszN MnzOV2FPT0WU
ATN-1 NUftbJdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTN4Lki1NVYh|ryP NWT5cVVHW0GQR1XS
HCC2998 NUnGOo5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLtTWM2OD1|Nj64OVcyKM7:TR?= MX3TRW5ITVJ?
UM-UC-3 NH7vOoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3Ne|BKSzVyPUO2Mlg3PzVizszN NY[2OVhKW0GQR1XS
DV-90 NHn0N25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTN4LkmwOlch|ryP M{DieHNCVkeHUh?=
ES8 NVzXZ3p6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN4LkmzNVgh|ryP NFXrR3RUSU6JRWK=
YAPC NHHTRWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;k[GlEPTB;M{[uPVY2PCEQvF2= Mo\3V2FPT0WU
HCC1599 NE\oV4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHETGMyUUN3ME2zO{4yPjF6IN88US=> NYS2SnNKW0GQR1XS
UMC-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32ySWlEPTB;M{euNlUxOyEQvF2= M3znOXNCVkeHUh?=
THP-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTuTWM2OD1|Nz6yPFY5KM7:TR?= M3TDcXNCVkeHUh?=
OCUB-M MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnycHVKSzVyPUO3MlI5QTFizszN MofqV2FPT0WU
NCI-H1693 NUDpc5NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTN5LkOyN|Mh|ryP MXLTRW5ITVJ?
NCI-H345 NFvaWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XWdGlEPTB;M{euN|YzPCEQvF2= MoXnV2FPT0WU
COLO-800 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTN5LkW2O{DPxE1? MkDjV2FPT0WU
COLO-320-HSR Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjONo93UUN3ME2zPE4{PDl{IN88US=> MX3TRW5ITVJ?
NCI-H596 NVrYSJVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjXZXNKSzVyPUO4MlQ1QDlizszN NIPn[lNUSU6JRWK=
NCI-H187 M3j2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTtTWM2OD1|OD63N|Q1KM7:TR?= MnLLV2FPT0WU
ECC4 M4\DO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GwVGlEPTB;M{muNFgyPCEQvF2= NXjXWJgzW0GQR1XS
KP-4 NEHoNGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPYeXFKSzVyPUO5MlEzOzVizszN M2jZbHNCVkeHUh?=
NCI-H2227 NFezR45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN7LkO5OFkh|ryP M3jTcnNCVkeHUh?=
22RV1 M2rBVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTN7LkizPVgh|ryP MmjMV2FPT0WU
SAS NHHjUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DZWGlEPTB;NECuNFk3KM7:TR?= Mn3NV2FPT0WU
PANC-10-05 M3rIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK4Rm5KSzVyPUSwMlE5OjhizszN MVPTRW5ITVJ?
MDA-MB-468 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzrRnRKSzVyPUSwMlU{PDZizszN NY\STIp7W0GQR1XS
RPMI-7951 NH35VZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[wO2lEPTB;NEGuNlA4PSEQvF2= NU\JSZdXW0GQR1XS
BB49-HNC NY[2c4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvVOG5zUUN3ME20NU4zOTd7IN88US=> M2fDWXNCVkeHUh?=
23132-87 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1exW2lEPTB;NEGuNlc{OiEQvF2= MUnTRW5ITVJ?
HCC1569 NWTnVWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\2[GxKSzVyPUSxMlI5QDVizszN MmXwV2FPT0WU
CP66-MEL NF;BN|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuzbGNpUUN3ME20Nk4yQDh4IN88US=> NYjKOpk4W0GQR1XS
K-562 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTR{LkK4OVQh|ryP NV\MSFRjW0GQR1XS
OCI-AML2 NEC0VHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkmzTWM2OD12Mj64PVc1KM7:TR?= MVzTRW5ITVJ?
SW756 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TSb2lEPTB;NEOuNFM5QCEQvF2= M{LmUXNCVkeHUh?=
M14 NIS4XGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXrTWM2OD12Mz6zNVg6KM7:TR?= M320fXNCVkeHUh?=
NCI-H1623 M{HKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR|LkS2OEDPxE1? NWfHRWhrW0GQR1XS
KNS-81-FD MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELVS3BKSzVyPUSzMlc3OiEQvF2= NH3TfXNUSU6JRWK=
TGBC1TKB NWnmRVV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnIfGRKSzVyPUSzMlkxQTlizszN M1PWPXNCVkeHUh?=
RERF-LC-MS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL3cYhkUUN3ME20N{46OjhzIN88US=> NXO1enlbW0GQR1XS
PC-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR2LkSzOFch|ryP M3zqR3NCVkeHUh?=
HuP-T4 NH3ud3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[0dWlEPTB;NESuOFQ4PCEQvF2= M{fEXXNCVkeHUh?=
NCI-H510A NVHHU5ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xkc2lEPTB;NESuO|A5KM7:TR?= MonmV2FPT0WU
LB2518-MEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vxU2lEPTB;NESuO|k{PyEQvF2= M2ThN3NCVkeHUh?=
TE-5 M3H2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDo[YxVUUN3ME20OU46PThzIN88US=> NYLpcWpzW0GQR1XS
EW-24 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTR4LkG3NlMh|ryP NFLK[XFUSU6JRWK=
LB647-SCLC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4H1O2lEPTB;NE[uNlE2PSEQvF2= M4fDWXNCVkeHUh?=
NCI-H524 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPtc3JKUUN3ME20Ok44OTh3IN88US=> M{GyeHNCVkeHUh?=
EW-11 NHXFN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\2TWM2OD12Nj65N|c{KM7:TR?= M4fBSnNCVkeHUh?=
KALS-1 M1;0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTR5LkKwOlYh|ryP M4jZOnNCVkeHUh?=
BT-474 NEXab4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvZRVhbUUN3ME20O{41OjF4IN88US=> NWiySG9FW0GQR1XS
SK-N-AS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf3XG9MUUN3ME20O{45QDhizszN NUHoU2xXW0GQR1XS
HCC2157 MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjPTWM2OD12OD6wO|Yh|ryP NGPFcGhUSU6JRWK=
HCC1954 Mm\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLBV3BKSzVyPUS4MlE4ODRizszN NUXLRVdzW0GQR1XS
FADU MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4npc2lEPTB;NEiuN|A{OSEQvF2= NI\xUm5USU6JRWK=
S-117 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvYTWM2OD12OD6zPFE2KM7:TR?= MlK1V2FPT0WU
LS-1034 M2DJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojGTWM2OD12OD63NFY4KM7:TR?= NEf2UIJUSU6JRWK=
CAMA-1 M2O2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13YPWlEPTB;NEmuOVU1OyEQvF2= MVnTRW5ITVJ?
LU-134-A NHPVO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjYTWM2OD12OT64NFg2KM7:TR?= MVHTRW5ITVJ?
NCI-H1838 NHTGR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPXTWM2OD12OT64NFg4KM7:TR?= MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID