Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Cited by 31 Publications

6 Customer Reviews

  • Immunoblot of H23 cells treated with trametinib (25 nM), ponatinib (750 nM), or their combination for the times shown.

    Nature, 2016, 534(7609):647-51. Ponatinib (AP24534) purchased from Selleck.

     

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

  • Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

    The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

  • Western blot analysis of lysates of Ba/F3 cells expressing BCR/ABL and BCR/ABL-T315I using antibodies directed against: c-ABL, ABL-Y245 (anti-phospho-ABL), Crkl, phosphorylated Crkl, STAT5, phosphorylated STAT5 (anti-phospho-STAT5) and β-tubulin (anti-β-tubulin). Molecular mass references (kDa) are presented, and c-ABL and β-Tubulin were used as a loading control.

    Leukemia, 2015, 29(5):1104-14. Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NVXsdG5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfFW4FrUUN3ME2wMlAxODByMECzOVkh|ryP MVjTRW5ITVJ?
MV-4-11 NHThVIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;uUWFKSzVyPUCuNFAxODl3NjFOwG0> NY\qSoZXW0GQR1XS
MEG-01 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[wb3ZKSzVyPUCuNFAxOTJ6IN88US=> MVrTRW5ITVJ?
LAMA-84 NIDLbHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzNeWNKSzVyPUCuNFAxOTZ3IN88US=> NUfoUnBYW0GQR1XS
CGTH-W-1 NF3PNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;0e2lEPTB;MD6wNFE3QSEQvF2= MYfTRW5ITVJ?
KASUMI-1 Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCTWM2OD1yLkCwNlE4KM7:TR?= M{TVc3NCVkeHUh?=
BE-13 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMECyOVkh|ryP NGeyVoNUSU6JRWK=
CTV-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEC1NlEh|ryP NWXFbGNNW0GQR1XS
NKM-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojQTWM2OD1yLkCwOlU2KM7:TR?= M3TPW3NCVkeHUh?=
MONO-MAC-6 NEj3bWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn5b3dVUUN3ME2wMlAxQDN5IN88US=> M1fkcnNCVkeHUh?=
A204 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvRW2FkUUN3ME2wMlAyOjF6IN88US=> MnXwV2FPT0WU
GDM-1 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETicIVKSzVyPUCuNFE5OzNizszN NYG0UoNoW0GQR1XS
AN3-CA NV;VeVh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3LR3d4UUN3ME2wMlAyQDd|IN88US=> NHHUeXRUSU6JRWK=
BL-70 NH\DeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEKxPVkh|ryP MXrTRW5ITVJ?
Daudi MorPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEK1N|ch|ryP NGj0d|FUSU6JRWK=
KU812 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K2[GlEPTB;MD6wNlg1QCEQvF2= MXPTRW5ITVJ?
KG-1 MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTxeIlKSzVyPUCuNFMzQTRizszN NHO5TnVUSU6JRWK=
DOHH-2 NVe5cmdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMES4NFMh|ryP M3fuUnNCVkeHUh?=
HuO9 NEX4N3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[0VGlEPTB;MD6wOVQ1QCEQvF2= MWHTRW5ITVJ?
EB2 NWjXTYxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLmTWM2OD1yLkC1OVc3KM7:TR?= MXfTRW5ITVJ?
G-402 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwME[zOFEh|ryP M4HseXNCVkeHUh?=
SU-DHL-1 NFvrdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwME[zO|kh|ryP NUe0V4FvW0GQR1XS
NCI-H719 NUTOPFNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYCybW5EUUN3ME2wMlA4QDh6IN88US=> MWPTRW5ITVJ?
MLMA MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\FTWM2OD1yLkC5NFYh|ryP NHvyUVhUSU6JRWK=
KM12 MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TWV2lEPTB;MD6wPVc{PyEQvF2= MWfTRW5ITVJ?
SUP-T1 NV73UmJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEm5PFIh|ryP MYPTRW5ITVJ?
MZ1-PC MkjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMUGzN|Yh|ryP M{jL[XNCVkeHUh?=
MFE-296 NEHPSGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki0TWM2OD1yLkGxPFM6KM7:TR?= NYTKS3NXW0GQR1XS
ALL-PO NUjkeIZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDJeGxKSzVyPUCuNVI1PDNizszN M{jKUXNCVkeHUh?=
GB-1 M4LTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfBTWM2OD1yLkGyOVEzKM7:TR?= NHmyS2ZUSU6JRWK=
SIG-M5 M1TINGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XjdGlEPTB;MD6xN|M4KM7:TR?= M3XhPXNCVkeHUh?=
P30-OHK Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PsUmlEPTB;MD6xOVY4OiEQvF2= NHmyWJRUSU6JRWK=
NCI-H716 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPZcGFnUUN3ME2wMlE3OjZ4IN88US=> NGizb45USU6JRWK=
MPP-89 MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUKzNYI3UUN3ME2wMlE3QTN|IN88US=> NEXHeo1USU6JRWK=
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljyTWM2OD1yLkG3NFY{KM7:TR?= NFO2U45USU6JRWK=
CTB-1 MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnzO4NKSzVyPUCuNVc{OTZizszN MmDxV2FPT0WU
CA46 M4XEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7TWI9KSzVyPUCuNVc1QDlizszN M33GZXNCVkeHUh?=
NCI-H520 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLZR2hJUUN3ME2wMlE4PzN{IN88US=> Ml2wV2FPT0WU
CAL-85-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHKXXJKSzVyPUCuNVc6OjdizszN NUfzS2lIW0GQR1XS
NCI-H2342 NIDuNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj6SmVKSzVyPUCuNVg2PzdizszN Mor4V2FPT0WU
697 Ml3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfER5RKSzVyPUCuNVg5PzFizszN NH7tc|JUSU6JRWK=
NY Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoT2TWM2OD1yLkG5Nlg4KM7:TR?= MkDGV2FPT0WU
T98G NVOzNY9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTxZVJyUUN3ME2wMlE6OzF6IN88US=> MX\TRW5ITVJ?
NCI-H1703 M1;jUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDFU29[UUN3ME2wMlE6PjF3IN88US=> NVjXU5BmW0GQR1XS
NCI-H2087 NFrQSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;KTWM2OD1yLkKwOFM6KM7:TR?= MWPTRW5ITVJ?
PF-382 NUG1UVBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWwXW5KSzVyPUCuNlA5PzNizszN NX:2fpdEW0GQR1XS
HCT-116 NVzwO4ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLOW2JKSzVyPUCuNlExPjlizszN NXn1NXl3W0GQR1XS
CAKI-1 Mki3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnWOHhtUUN3ME2wMlIyPjZ4IN88US=> Mke4V2FPT0WU
CCF-STTG1 NUPXPWMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMkK0O|Uh|ryP M3PnNnNCVkeHUh?=
D-392MG M2Oxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DXbmlEPTB;MD6yN|E4PyEQvF2= MYDTRW5ITVJ?
RT-112 NEG3VpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzoZ|BoUUN3ME2wMlI{Pzl3IN88US=> MWjTRW5ITVJ?
MES-SA NVXySY1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPm[|VKSzVyPUCuNlQyQDdizszN MkHyV2FPT0WU
LC-2-ad NHHNUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfEN3VUUUN3ME2wMlI1OjZ3IN88US=> NHLzV5RUSU6JRWK=
NOS-1 NX7ncVdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mwb2lEPTB;MD6yOFM3PyEQvF2= MoC1V2FPT0WU
NALM-6 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDKOGpKSzVyPUCuNlU2PDNizszN M3PQVXNCVkeHUh?=
TE-15 M{L6bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOyfmExUUN3ME2wMlI3ODlzIN88US=> NILCSpNUSU6JRWK=
786-0 Ml3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrMTWM2OD1yLkK2NlI5KM7:TR?= NH;2V4NUSU6JRWK=
IST-MES1 M37X[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LhdWlEPTB;MD6yOlgzQSEQvF2= NIjHblhUSU6JRWK=
KYSE-180 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrKVldyUUN3ME2wMlI3QDlzIN88US=> MXLTRW5ITVJ?
YT MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4mwWmlEPTB;MD6yOlk4PCEQvF2= M{LKWHNCVkeHUh?=
A427 NVrUPGs4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX5[4pKSzVyPUCuNlczPjRizszN M4CzPXNCVkeHUh?=
KYSE-450 NHvFNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDhcm5KSzVyPUCuNlc{OjlizszN MVPTRW5ITVJ?
HuH-7 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwMke3OlMh|ryP MliyV2FPT0WU
CAS-1 NEDnOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\KWXFJUUN3ME2wMlI5OzB|IN88US=> M3iwOnNCVkeHUh?=
KURAMOCHI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\rTWM2OD1yLkK4OFE6KM7:TR?= M1L5fXNCVkeHUh?=
ACHN NXjlcZJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfnVotJUUN3ME2wMlI6OzJ|IN88US=> NVvMUFN[W0GQR1XS
HGC-27 NEG4WlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT3V2hKSzVyPUCuNlk{PTNizszN M13oUnNCVkeHUh?=
A172 M4LaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTZTVFWUUN3ME2wMlI6PTd5IN88US=> NXLsPHNjW0GQR1XS
SNU-449 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMkm5OlQh|ryP MVHTRW5ITVJ?
SW982 M4m3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TNXmlEPTB;MD6yPVk4QCEQvF2= MmDpV2FPT0WU
EFO-21 NXzITlBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\yOWlEPTB;MD6zNFQyOSEQvF2= MoXLV2FPT0WU
NCI-H2030 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;rbWlEPTB;MD6zNVE3PCEQvF2= NULpRXFmW0GQR1XS
HT-144 NGrPXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqzTWM2OD1yLkOxNlgh|ryP NH7LRlVUSU6JRWK=
MFE-280 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvJTWM2OD1yLkOxOFU{KM7:TR?= MkPmV2FPT0WU
SK-LU-1 NV\MXFN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknmTWM2OD1yLkOxOFY3KM7:TR?= NXP4S4tQW0GQR1XS
NCI-H2052 M1L3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrPbFFKSzVyPUCuN|E1QDRizszN NHLVcphUSU6JRWK=
SK-HEP-1 NE\kVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;UTWM2OD1yLkOzN|Y5KM7:TR?= NH7DU4hUSU6JRWK=
QIMR-WIL NWXY[W92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjVTWM2OD1yLkOzOFI1KM7:TR?= NYnre2xnW0GQR1XS
A2780 Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;UN|VKSzVyPUCuN|Q{ODRizszN MYfTRW5ITVJ?
ACN NF;ofWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr5TWM2OD1yLkO0PFc{KM7:TR?= MojaV2FPT0WU
BxPC-3 NYPuSW5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfVTWM2OD1yLkO0PVg6KM7:TR?= MlP6V2FPT0WU
BCPAP NG\UT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfVTWM2OD1yLkO2NFAyKM7:TR?= M2TUb3NCVkeHUh?=
HOP-62 M4WzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDIOXpKSzVyPUCuN|YyODZizszN MoXRV2FPT0WU
SW1710 NVHMUXJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnLSGdCUUN3ME2wMlM3PDV3IN88US=> M2nmS3NCVkeHUh?=
OPM-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jTTGlEPTB;MD6zOlQ4OyEQvF2= NIPoN2pUSU6JRWK=
DBTRG-05MG M2KydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwM{iwOVQh|ryP MUTTRW5ITVJ?
SK-MEL-24 MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWezWXJ5UUN3ME2wMlM6PzlzIN88US=> MUPTRW5ITVJ?
8305C NYrHeldwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIL1O|dKSzVyPUCuN|k4QTNizszN M2TmZnNCVkeHUh?=
OVCAR-4 M3;OUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr3cWszUUN3ME2wMlQyPTh4IN88US=> MnnyV2FPT0WU
HLE NIW5SHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PQWWlEPTB;MD60NVg3KM7:TR?= NVjacHVFW0GQR1XS
NCI-H747 M2\hSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rPSWlEPTB;MD60NlE{PyEQvF2= M3vQOXNCVkeHUh?=
SW780 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXWZoxKSzVyPUCuOFI{PDZizszN MkP0V2FPT0WU
KYSE-150 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D1W2lEPTB;MD60NlQyPSEQvF2= MWnTRW5ITVJ?
H4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\ITWM2OD1yLkSyOFUyKM7:TR?= Mn3MV2FPT0WU
SW1088 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu4NGJ6UUN3ME2wMlQ1OzlizszN M37pSHNCVkeHUh?=
SF268 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnhUVI6UUN3ME2wMlQ1QDZizszN MkTtV2FPT0WU
RT4 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T2WmlEPTB;MD60OVEyOSEQvF2= NHy1XXZUSU6JRWK=
NCI-H522 NVHXfWExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwNEWyO{DPxE1? M1rCUXNCVkeHUh?=
LCLC-97TM1 M2jKcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HYVWlEPTB;MD60OlE6PSEQvF2= NVvmSG5QW0GQR1XS
CAL-39 M3HL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fNfWlEPTB;MD60OlUyQSEQvF2= MWjTRW5ITVJ?
CAL-120 M4\hVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTIbVNKSzVyPUCuOFc3PDNizszN NX7NPGRWW0GQR1XS
ESS-1 M1TZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTlTWM2OD1yLkS3PFIyKM7:TR?= NWLW[ZU{W0GQR1XS
KARPAS-45 MnnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnHPXJKSzVyPUCuOFg6OzNizszN NYLQc5V6W0GQR1XS
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NCI-H810 NFvzRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\oWWlEPTB;MT64NVYxPiEQvF2= MmfVV2FPT0WU
SK-NEP-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPpU|JXUUN3ME2xMlg{PzZ5IN88US=> MmHUV2FPT0WU
D-542MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzFVYhFUUN3ME2xMlg2QDVzIN88US=> M{nVXHNCVkeHUh?=
KNS-42 M2DKO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LCO2lEPTB;MT64OlI3PiEQvF2= MVvTRW5ITVJ?
NCI-H2452 M37XPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nRSWlEPTB;MT64PVA4PCEQvF2= MkXPV2FPT0WU
SK-MEL-2 NV7aOJNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXI[ndKSzVyPUGuPVAzPzFizszN NXvLRmxnW0GQR1XS
OVCAR-5 NHiwWHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\NfI5tUUN3ME2xMlkxPjd3IN88US=> NEXHb3lUSU6JRWK=
SNG-M NXjaSmRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7lSm9KSzVyPUGuPVU5PThizszN NFjWZYNUSU6JRWK=
A673 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlniTWM2OD1zLkm3OVE3KM7:TR?= NFrHUG1USU6JRWK=
L-428 M1PESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LMZWlEPTB;MT65PVE4QSEQvF2= MULTRW5ITVJ?
KM-H2 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ruSGlEPTB;Mj6wNVA6KM7:TR?= NVy1NYg1W0GQR1XS
MC-IXC M1LseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPrRXRQUUN3ME2yMlAzOjd|IN88US=> MWnTRW5ITVJ?
COLO-678 NI\vVoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmzVoRoUUN3ME2yMlA1OjB5IN88US=> MX3TRW5ITVJ?
MEL-JUSO NXH3bIJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnBNWlKSzVyPUKuNFc5PTFizszN MYDTRW5ITVJ?
HCC38 Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJwMEi0N|Mh|ryP MXvTRW5ITVJ?
UACC-62 NELiZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf0dWZ{UUN3ME2yMlA5QDV3IN88US=> MUjTRW5ITVJ?
OAW-42 M{i5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLkTWM2OD1{LkC5O|EyKM7:TR?= M3;IfXNCVkeHUh?=
LB996-RCC M3v1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DQXmlEPTB;Mj6xN|gyPyEQvF2= MnvQV2FPT0WU
COR-L105 MoXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjybZQ1UUN3ME2yMlE3Ozd|IN88US=> M4r0PXNCVkeHUh?=
RCC10RGB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7qPHBKSzVyPUKuNVg2PzZizszN MkXHV2FPT0WU
A431 NXW1cY1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJwMUmwNVkh|ryP NV\kOFAyW0GQR1XS
NCI-H292 NYr4VoNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJwMkO5OVEh|ryP NHnMWXBUSU6JRWK=
SK-UT-1 NVP4WWRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPnTWM2OD1{LkOzNVg1KM7:TR?= MX;TRW5ITVJ?
PANC-08-13 M1TuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnPTWM2OD1{LkOzNlM2KM7:TR?= MlHRV2FPT0WU
ST486 NYTKd2t7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTqTWM2OD1{LkSxNFQ5KM7:TR?= M{LpbHNCVkeHUh?=
SJSA-1 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPKTWM2OD1{LkSxNlcyKM7:TR?= MkPlV2FPT0WU
RKO NEDOW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XneWlEPTB;Mj60NlAzQSEQvF2= MVnTRW5ITVJ?
NCI-H1793 M4P6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInnOYNKSzVyPUKuOFQxOjlizszN MVXTRW5ITVJ?
639-V MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfIZ|JKSzVyPUKuOFU{QDJizszN NVz2PZR5W0GQR1XS
ES3 NEfVPHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS5S2pKSzVyPUKuOFk4OzdizszN NH7kbGxUSU6JRWK=
NCI-H1792 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHyS44yUUN3ME2yMlU3QDJ4IN88US=> M3XLNHNCVkeHUh?=
NCI-H1651 M4LmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjNS2oxUUN3ME2yMlU5OjFizszN MojKV2FPT0WU
SN12C M13hRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrnSoZKSzVyPUKuOVg1QDdizszN NGmxWVBUSU6JRWK=
COLO-679 MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwNUi2NFUh|ryP NYf6OppIW0GQR1XS
U-118-MG NF\HOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKzdGVKSzVyPUKuOVg5PzJizszN NE\qdJlUSU6JRWK=
Ramos-2G6-4C10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojSTWM2OD1{Lk[0PFA4KM7:TR?= MkfpV2FPT0WU
HCT-15 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPxTWM2OD1{Lk[4O|kzKM7:TR?= MXrTRW5ITVJ?
MDA-MB-157 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fIbGlEPTB;Mj63NFc1PyEQvF2= NVruO2VoW0GQR1XS
K5 NEDWdVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XlT2lEPTB;Mj63NVg1PSEQvF2= MYnTRW5ITVJ?
MKN45 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTKWpFKSzVyPUKuO|M{PjZizszN M32xenNCVkeHUh?=
DMS-273 NVO3PWVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jE[GlEPTB;Mj63OVY{OiEQvF2= MWPTRW5ITVJ?
C8166 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvrS5ZKSzVyPUKuO|g2OTNizszN MnvLV2FPT0WU
Calu-3 MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37FbmlEPTB;Mj63PFk3QSEQvF2= MlvtV2FPT0WU
SNB75 M{fpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDJTWM2OD1{Lki4OVM2KM7:TR?= NXrWNZB2W0GQR1XS
BFTC-905 NWLVbJNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\GTWM2OD1{LkmwNVkyKM7:TR?= NYfCRoZqW0GQR1XS
C-4-II M1XPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3QN5VKSzVyPUKuPVE{PTNizszN NFnLU29USU6JRWK=
MS-1 M1XYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvPTWM2OD1{Lkm2O|Y6KM7:TR?= MXrTRW5ITVJ?
A375 NX\U[GlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTNwMEixPFQh|ryP NYfue4FKW0GQR1XS
KYSE-70 NWm5[2Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3oTWM2OD1|LkC4PFgzKM7:TR?= M1vG[XNCVkeHUh?=
KYSE-510 NHzPOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\RUVJKSzVyPUOuNVA6QTVizszN MluwV2FPT0WU
LN-405 NVTCWWE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LkVWlEPTB;Mz6xN|UyQCEQvF2= M4LLPHNCVkeHUh?=
BOKU MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHpUGdKSzVyPUOuNVQzPTZizszN MWnTRW5ITVJ?
TE-10 NFnZOY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XaPWlEPTB;Mz6xO|M3OiEQvF2= M1nlenNCVkeHUh?=
MKN1 M4PMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzaWYVuUUN3ME2zMlE5PDh|IN88US=> NVvVUnoxW0GQR1XS
M059J M{LuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DBb2lEPTB;Mz6yNFE4OyEQvF2= MnG3V2FPT0WU
GOTO MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHqNIFKSzVyPUOuNlIxOzlizszN M{\0O3NCVkeHUh?=
DK-MG NI\DcZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G5OGlEPTB;Mz6yOVk4PiEQvF2= NIfZOYFUSU6JRWK=
NCI-H727 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTNwMk[1PEDPxE1? NVXVNYpmW0GQR1XS
NB12 NYjtdGVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jJR2lEPTB;Mz6zN|IzPCEQvF2= MnPrV2FPT0WU
DOK NGL4OXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTNwM{[xPFYh|ryP NEm4SmZUSU6JRWK=
KYSE-410 NIfW[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fIV2lEPTB;Mz6zOlI5PyEQvF2= M1vKdHNCVkeHUh?=
AM-38 M{LqdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW4TWM2OD1|LkO4NFUyKM7:TR?= M4SwO3NCVkeHUh?=
GR-ST NUP6XmtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTNwNEW3N|Ih|ryP MVzTRW5ITVJ?
D-247MG M3S3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\kSmlEPTB;Mz60PFI3OyEQvF2= NE\lU|RUSU6JRWK=
TE-8 NF:wenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofKTWM2OD1|LkS5N|M{KM7:TR?= MV7TRW5ITVJ?
LS-411N NHWxc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvhVG5pUUN3ME2zMlQ6Pjl{IN88US=> NHPmT2RUSU6JRWK=
SK-MES-1 NUDORXVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNwNU[0N|Mh|ryP MV\TRW5ITVJ?
SF295 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTNwNkG1OVIh|ryP NV71cpdQW0GQR1XS
SK-MEL-30 NVvTNI9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnsTWM2OD1|Lk[1PVIyKM7:TR?= Mlq3V2FPT0WU
LB2241-RCC M3jaU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTNwNk[yOkDPxE1? M4S5[3NCVkeHUh?=
PC-14 NGLPSnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDaTWM2OD1|Lk[2OFM4KM7:TR?= MoGwV2FPT0WU
EW-7 M3HhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TieGlEPTB;Mz62O|Y6OyEQvF2= NV\5emw5W0GQR1XS
NMC-G1 NYrX[nBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDLTWM2OD1|LkexPFM4KM7:TR?= M1zKUnNCVkeHUh?=
TE-441-T MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTNwN{OwNlgh|ryP M2DKT3NCVkeHUh?=
NCI-H1618 M3LEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD5dHlKSzVyPUOuPFE5PzVizszN MUHTRW5ITVJ?
PANC-03-27 M2P3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTNwOEG5NVYh|ryP MonLV2FPT0WU
NCI-H2228 NUiwXFR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\ERWlEPTB;Mz64N|EzPiEQvF2= M1P3e3NCVkeHUh?=
CAPAN-1 M3X3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTYTWM2OD1|Lki3NFA6KM7:TR?= M1foe3NCVkeHUh?=
KLE NY\tOpZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrLeWY2UUN3ME2zMlkxPjdizszN MUTTRW5ITVJ?
Becker MmriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzlb3ZKSzVyPUOuPVI5PDlizszN NHPINGNUSU6JRWK=
SK-PN-DW MljJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLBWWlKSzVyPUSuNFc6PzRizszN MYfTRW5ITVJ?
Hs-578-T MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGzWVFKSzVyPUSuNFg{ODZizszN M3jlVXNCVkeHUh?=
RS4-11 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnITWM2OD12LkGxNlU2KM7:TR?= M2DwOXNCVkeHUh?=
D-502MG MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTRwMU[5PVch|ryP MmrxV2FPT0WU
GI-1 MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LLXmlEPTB;ND6yPFI6QSEQvF2= MnPjV2FPT0WU
NCI-H209 M3zxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjVblFUUUN3ME20MlM{PzhizszN M1LXZXNCVkeHUh?=
SK-OV-3 MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS3U3l3UUN3ME20MlQ5OTR7IN88US=> NHP4NpNUSU6JRWK=
LOUCY NGXZW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L2cWlEPTB;ND60PFQ{OiEQvF2= MVXTRW5ITVJ?
NCI-H69 NGD2UHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDhO3dKSzVyPUSuOVE4QTNizszN MXnTRW5ITVJ?
SCC-9 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{i2WWlEPTB;ND61N|E4OiEQvF2= NFfOb25USU6JRWK=
NCI-H526 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjwTWM2OD12LkW5Nlk{KM7:TR?= Mn3zV2FPT0WU
NCI-H2170 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TJdGlEPTB;ND62Olc4OSEQvF2= MUPTRW5ITVJ?
SR NV;WR4RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTRwN{CwOFgh|ryP NWDp[|RkW0GQR1XS
CMK M1vBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfqd5B6UUN3ME20MlczOTBzIN88US=> NWLiW4w5W0GQR1XS
COLO-829 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTRwN{ewOFMh|ryP MnvZV2FPT0WU
HuO-3N1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GxTmlEPTB;ND64N|I5OSEQvF2= MmPmV2FPT0WU
5637 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzvTWM2OD12LkmwOFg4KM7:TR?= M3\EcXNCVkeHUh?=
A253 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTRwOUe3NFgh|ryP NYDMWZFzW0GQR1XS
NB10 M4j1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTVwMEe0PVch|ryP M2rCdHNCVkeHUh?=
SF539 NW[weFNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\OPWVqUUN3ME21MlA6QTV7IN88US=> MkK1V2FPT0WU
HAL-01 NVTNS4kyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom0TWM2OD13LkG0OlQ2KM7:TR?= M2jOdHNCVkeHUh?=
MHH-ES-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTVwMU[5NlUh|ryP M2DjN3NCVkeHUh?=
DEL M{DxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfjTWM2OD13LkK3OVgzKM7:TR?= NGO1RVdUSU6JRWK=
NCI-H1299 M2PPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTVwM{WwNFch|ryP NFj2c4RUSU6JRWK=
ChaGo-K-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHvV|dKSzVyPUWuN|UyODdizszN MlvtV2FPT0WU
HMV-II MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTVwM{m0N{DPxE1? MnLWV2FPT0WU
NB69 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjsb4tIUUN3ME21MlM6PjNzIN88US=> NGrw[JhUSU6JRWK=
NCI-H1882 M2Hs[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTVwNEOzOlQh|ryP NEDQUXZUSU6JRWK=
SNU-475 NU[xcldqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX23No8xUUN3ME21MlQ4OTdzIN88US=> NVXU[oY3W0GQR1XS
RXF393 NIrnXGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO5TWM2OD13LkS4OFk1KM7:TR?= M3r3VXNCVkeHUh?=
CAL-51 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHYRXFFUUN3ME21MlYzQDV|IN88US=> M3nMVnNCVkeHUh?=
SW1573 NHXSOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33SW2lEPTB;NT62N|U{PCEQvF2= MVvTRW5ITVJ?
GCT NUCzOJBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHFTWM2OD13Lke1PVI6KM7:TR?= MorMV2FPT0WU
COR-L88 NWO0N41QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTVwN{[4OFYh|ryP M3ixbnNCVkeHUh?=
MDA-MB-134-VI MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDCVWRKSzVyPUWuPFc2OzZizszN NET6UZNUSU6JRWK=
NB5 NV75XYs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\DTWM2OD13LkmyOFQh|ryP MoLvV2FPT0WU
GMS-10 MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7p[IxrUUN3ME21Mlk3QDZzIN88US=> M2DXUHNCVkeHUh?=
CHP-212 NGD1WVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlu3TWM2OD14LkS4NlY4KM7:TR?= MmfCV2FPT0WU
TE-11 NYnFWJVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnCbZZOUUN3ME22MlU2OTh{IN88US=> MYfTRW5ITVJ?
SW962 NGm2V|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW5fZZKSzVyPU[uOlU4PzRizszN M{\s[XNCVkeHUh?=
MZ2-MEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe4NphKSzVyPU[uPFIxOTFizszN MkPBV2FPT0WU
C-33-A NETOe2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PxPGlEPTB;Nj65NVY5QCEQvF2= NGK3UGdUSU6JRWK=
IGR-1 NUPKRpo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HqTWlEPTB;Nj65O|gzPiEQvF2= NG\UVHhUSU6JRWK=
MOLT-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXGO|RKSzVyPUeuNVU1ODZizszN Mn7KV2FPT0WU
NCI-H1650 NHTrbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLWNotKSzVyPUeuNlcxPDZizszN MkHDV2FPT0WU
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NCI-H630 NWjDe4VHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJ{LkWzOlMh|ryP MmXWV2FPT0WU
LU-165 M163[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HsWmlEPTB;MkKuOVU1KM7:TR?= M4PmPHNCVkeHUh?=
COLO-792 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrGRVVKSzVyPUKyMlcyOTFizszN NWS4b3FoW0GQR1XS
CAL-62 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfSTWM2OD1{Mj63OVE4KM7:TR?= MmPuV2FPT0WU
HCE-T NI\TclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJ{Lki2NFYh|ryP MnjWV2FPT0WU
BB65-RCC MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ|LkCzOFQh|ryP MUHTRW5ITVJ?
SiHa NHe4OnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlX4TWM2OD1{Mz6zPVY5KM7:TR?= M37CR3NCVkeHUh?=
NCI-H2081 M1XUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7qcFFUUUN3ME2yOE4xPjRzIN88US=> NG\QcYxUSU6JRWK=
U251 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj2d|FKSzVyPUK0MlA3PjhizszN MYPTRW5ITVJ?
LoVo MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorNTWM2OD1{ND65NlgzKM7:TR?= MYPTRW5ITVJ?
GCIY MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\OfVFxUUN3ME2yOU4zQDd5IN88US=> MV7TRW5ITVJ?
NUGC-3 MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mzNGlEPTB;MkWuN|MyPiEQvF2= NY\lPZFIW0GQR1XS
LNCaP-Clone-FGC MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;0fGlEPTB;MkWuN|Q6QCEQvF2= M{LlW3NCVkeHUh?=
PA-1 NV;xWIk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJ3Lk[4N|Mh|ryP NFjjXZdUSU6JRWK=
OE33 M2X2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXIW|N[UUN3ME2yOU43QDV|IN88US=> M{Ox[3NCVkeHUh?=
HT-29 M33I[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1SxPGlEPTB;MkWuO|g4QSEQvF2= NFfkb4FUSU6JRWK=
RCM-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkKwTWM2OD1{NT65OlU3KM7:TR?= M{jQWHNCVkeHUh?=
NCI-H1522 MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkWWlEPTB;MkWuPVkyOSEQvF2= M1[4R3NCVkeHUh?=
LB373-MEL-D MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\ZU|NUUUN3ME2yOk4yPzB6IN88US=> M2XJU3NCVkeHUh?=
NCI-H1436 M1jUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHT[IxKSzVyPUK2MlI4OzhizszN MnfvV2FPT0WU
COLO-824 NFHoWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\xTWM2OD1{Nj60NFAzKM7:TR?= M2L5WHNCVkeHUh?=
CP50-MEL-B MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4TXRrUUN3ME2yOk42Pjd3IN88US=> NW\4NlltW0GQR1XS
EGI-1 NFX0Z|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17BO2lEPTB;MkeuNlY6QCEQvF2= MWXTRW5ITVJ?
LAN-6 NXvrSHlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ5LkO1PVgh|ryP NG\BNYZUSU6JRWK=
GAK M3\wS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP5bG5UUUN3ME2yO{41OjJ3IN88US=> M1nlOnNCVkeHUh?=
MDA-MB-175-VII NEfTSGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\Od2lEPTB;MkeuOVA2OyEQvF2= M4HvPXNCVkeHUh?=
JVM-2 M4\4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\JTWM2OD1{Nz62OlIzKM7:TR?= NH\EVYRUSU6JRWK=
UACC-257 M3rtfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XH[GlEPTB;MkeuOlg4QCEQvF2= NIDpfpNUSU6JRWK=
SW1783 NH7HZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSwTGtZUUN3ME2yO{44Pzh|IN88US=> MlfYV2FPT0WU
HT-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XoeGlEPTB;MkiuNlE3PiEQvF2= NVLGd5FLW0GQR1XS
RL M17Me2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTLb5o6UUN3ME2yPE42QTFzIN88US=> M2ryRnNCVkeHUh?=
TK10 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[5fGlEPTB;MkiuOlU{PSEQvF2= NXP1WWp[W0GQR1XS
HT55 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTvTWM2OD1{OT6wOVY2KM7:TR?= NYG1NWZ7W0GQR1XS
BT-20 M1fiNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPxTWM2OD1{OT6wOVg3KM7:TR?= MXHTRW5ITVJ?
TGBC24TKB MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO0SHVKSzVyPUK5MlE5OzFizszN M2PUbnNCVkeHUh?=
HSC-2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\xOYpWUUN3ME2yPU4{ODBzIN88US=> MluwV2FPT0WU
COLO-205 Mn6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rSRmlEPTB;MkmuN|k1PCEQvF2= MYHTRW5ITVJ?
GT3TKB NFLyRldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HLPWlEPTB;MkmuOlg4PyEQvF2= MVHTRW5ITVJ?
T47D MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf4WItCUUN3ME2yPU45PTh{IN88US=> MojFV2FPT0WU
OMC-1 MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPt[GtKSzVyPUOwMlE6OTlizszN NVnTZXZtW0GQR1XS
PFSK-1 NEnpNXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHOTWM2OD1|MT6yOlU6KM7:TR?= NUDN[YVnW0GQR1XS
JEG-3 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnleotvUUN3ME2zNU4{PTZzIN88US=> MYjTRW5ITVJ?
RD NHrkOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL6TWM2OD1|MT61NVE2KM7:TR?= NWjK[WtIW0GQR1XS
NCI-H64 NGrtenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\3TWM2OD1|Mj60NVc6KM7:TR?= M4TuVHNCVkeHUh?=
DMS-114 NI\oU3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHQTWM2OD1|Mj60NVgzKM7:TR?= MVLTRW5ITVJ?
NCI-H661 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfJfZRKSzVyPUOyMlY2ODFizszN MWDTRW5ITVJ?
CAL-148 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1naeGlEPTB;M{KuOlY3PSEQvF2= M{fKPXNCVkeHUh?=
HuP-T3 NVTUN4I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W3SWlEPTB;M{KuPVM{QCEQvF2= NUfLWpp{W0GQR1XS
ES4 NGC5eWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHYTWM2OD1|Mz6xO|A2KM7:TR?= NGnMcopUSU6JRWK=
Ca9-22 MlWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rFTmlEPTB;M{OuOFYxOSEQvF2= NHLCfHhUSU6JRWK=
LP-1 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETHRndKSzVyPUO0MlA6KM7:TR?= M{PJUXNCVkeHUh?=
AU565 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLzd5JoUUN3ME2zOE42ODZ7IN88US=> MoraV2FPT0WU
MDA-MB-453 NXTNZ2NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTN3LkG0NlYh|ryP NUnNb2pkW0GQR1XS
SNU-C1 M4qzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTN3LkG3NUDPxE1? MoP2V2FPT0WU
SW13 M3LkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojBTWM2OD1|NT60NFc3KM7:TR?= NILIXVNUSU6JRWK=
NCI-H2122 M1LpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTN3LkW1PVgh|ryP MmS2V2FPT0WU
NCI-H1395 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq0NpJzUUN3ME2zOU43PjlzIN88US=> NV\5Z40zW0GQR1XS
J-RT3-T3-5 NV;JSWpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn5b|RKSzVyPUO2MlAzQTRizszN M2TIbXNCVkeHUh?=
COR-L279 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj5TWM2OD1|Nj6xPVgyKM7:TR?= MUPTRW5ITVJ?
ATN-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fwfWlEPTB;M{[uPFUyPiEQvF2= NH7K[Y5USU6JRWK=
HCC2998 NYfDN4RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN4Lki1O|Eh|ryP MkLxV2FPT0WU
UM-UC-3 M3TyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[xTWM2OD1|Nj64Olc2KM7:TR?= MUTTRW5ITVJ?
DV-90 NUnaZmZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP2bVZpUUN3ME2zOk46ODZ5IN88US=> MkjOV2FPT0WU
ES8 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnYTWM2OD1|Nj65N|E5KM7:TR?= M{jjenNCVkeHUh?=
YAPC M3nMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjZVZZKSzVyPUO2Mlk3PTRizszN M1S2XnNCVkeHUh?=
HCC1599 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX6SVBKSzVyPUO3MlE3OThizszN M{TZc3NCVkeHUh?=
UMC-11 MmD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN5LkK1NFMh|ryP NEG2RYZUSU6JRWK=
THP-1 M{\kVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknCTWM2OD1|Nz6yPFY5KM7:TR?= MWXTRW5ITVJ?
OCUB-M MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET4cpBKSzVyPUO3MlI5QTFizszN NWfCfYVlW0GQR1XS
NCI-H1693 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN5LkOyN|Mh|ryP MnnuV2FPT0WU
NCI-H345 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPZU|czUUN3ME2zO{4{PjJ2IN88US=> MWfTRW5ITVJ?
COLO-800 NGrMW3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTN5LkW2O{DPxE1? Mlq5V2FPT0WU
COLO-320-HSR NX3RW3dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DmW2lEPTB;M{iuN|Q6OiEQvF2= NH6yWHRUSU6JRWK=
NCI-H596 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7FWodKSzVyPUO4MlQ1QDlizszN NGPJeJBUSU6JRWK=
NCI-H187 NFGzPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HocmlEPTB;M{iuO|M1PCEQvF2= NYP5cFF2W0GQR1XS
ECC4 NE[wfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkOwTWM2OD1|OT6wPFE1KM7:TR?= NIXINZZUSU6JRWK=
KP-4 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnviTWM2OD1|OT6xNlM2KM7:TR?= MVXTRW5ITVJ?
NCI-H2227 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyWGlEPTB;M{muN|k1QSEQvF2= NYH1Zox3W0GQR1XS
22RV1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyTmlEPTB;M{muPFM6QCEQvF2= MVfTRW5ITVJ?
SAS MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj0elJuUUN3ME20NE4xQTZizszN NFfSSmhUSU6JRWK=
PANC-10-05 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRyLkG4Nlgh|ryP MYfTRW5ITVJ?
MDA-MB-468 NXHLNotIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vYWmlEPTB;NECuOVM1PiEQvF2= NIfMNIdUSU6JRWK=
RPMI-7951 MmXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDq[IxKSzVyPUSxMlIxPzVizszN NFjnd2dUSU6JRWK=
BB49-HNC M2jOUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX6R2hUUUN3ME20NU4zOTd7IN88US=> NYni[|dRW0GQR1XS
23132-87 NUXqZVVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS0N4xoUUN3ME20NU4zPzN{IN88US=> NHLDUopUSU6JRWK=
HCC1569 NHz3OJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDubHpVUUN3ME20NU4zQDh3IN88US=> Ml[zV2FPT0WU
CP66-MEL NHfYWoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\YcmlEPTB;NEKuNVg5PiEQvF2= NXOzNVJ{W0GQR1XS
K-562 NVXIUGlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq3TWM2OD12Mj6yPFU1KM7:TR?= NGi5bmhUSU6JRWK=
OCI-AML2 NIPSWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR{Lki5O|Qh|ryP MnWxV2FPT0WU
SW756 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHO1TGZKSzVyPUSzMlA{QDhizszN NWXVV2N1W0GQR1XS
M14 MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTR|LkOxPFkh|ryP NFyxWoZUSU6JRWK=
NCI-H1623 NWf0PGJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TRR2lEPTB;NEOuOFY1KM7:TR?= NG\PR4VUSU6JRWK=
KNS-81-FD M4LsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK1RXJKSzVyPUSzMlc3OiEQvF2= MVLTRW5ITVJ?
TGBC1TKB M1O3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fJWWlEPTB;NEOuPVA6QSEQvF2= M{W4THNCVkeHUh?=
RERF-LC-MS NHHMTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;zUnR2UUN3ME20N{46OjhzIN88US=> NWC1NHhjW0GQR1XS
PC-3 NXHwTHhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH5TWM2OD12ND60N|Q4KM7:TR?= NHXzVHpUSU6JRWK=
HuP-T4 NHnJZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml63TWM2OD12ND60OFc1KM7:TR?= MX7TRW5ITVJ?
NCI-H510A M2XGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\UcnRKSzVyPUS0MlcxQCEQvF2= MYXTRW5ITVJ?
LB2518-MEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zRTmlEPTB;NESuO|k{PyEQvF2= MorwV2FPT0WU
TE-5 NGW5RVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHezfXJKSzVyPUS1Mlk2QDFizszN NXP0W3hVW0GQR1XS
EW-24 NV\tOmZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3KTWM2OD12Nj6xO|I{KM7:TR?= MoiwV2FPT0WU
LB647-SCLC NUi0eYJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\uWnZKSzVyPUS2MlIyPTVizszN MUHTRW5ITVJ?
NCI-H524 MkDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTR4LkexPFUh|ryP M2D5eXNCVkeHUh?=
EW-11 Ml23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTETWM2OD12Nj65N|c{KM7:TR?= NHy5[VRUSU6JRWK=
KALS-1 MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nYSWlEPTB;NEeuNlA3PiEQvF2= M{\XbXNCVkeHUh?=
BT-474 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPkTWM2OD12Nz60NlE3KM7:TR?= NFnV[pRUSU6JRWK=
SK-N-AS M3j6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\vTWM2OD12Nz64PFgh|ryP MVnTRW5ITVJ?
HCC2157 NWT6NVFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTR6LkC3OkDPxE1? NFq3TW9USU6JRWK=
HCC1954 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;UfFhEUUN3ME20PE4yPzB2IN88US=> Mnr2V2FPT0WU
FADU M2j4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfJd3k4UUN3ME20PE4{ODNzIN88US=> MXzTRW5ITVJ?
S-117 NHLYVWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHwUplDUUN3ME20PE4{QDF3IN88US=> NF3zNndUSU6JRWK=
LS-1034 NXXEOGJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTR6LkewOlch|ryP MX7TRW5ITVJ?
CAMA-1 M3LDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPENXNKSzVyPUS5MlU2PDNizszN NG\oW|FUSU6JRWK=
LU-134-A NVe1bphIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPkW4pKSzVyPUS5MlgxQDVizszN M1izfXNCVkeHUh?=
NCI-H1838 M{TjOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzRO3BKSzVyPUS5MlgxQDdizszN MnnjV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03838692 Not yet recruiting Medullary Thyroid Cancer Antonio Fojo|Millennium Pharmaceuticals Inc.|Columbia University April 2019 Phase 2
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2
NCT03807479 Recruiting Leukemia Myeloid Chronic-Phase GWT-TUD GmbH|Incyte Biosciences International Sàrl December 11 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

Bcr-Abl Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID