Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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4 Customer Reviews

  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NFi4flBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;1OIh2UUN3ME2wMlAxODByMECzOVkh|ryP MX7TRW5ITVJ?
MV-4-11 MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D3UWlEPTB;MD6wNFAxQTV4IN88US=> MnvzV2FPT0WU
MEG-01 M4P0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\neJpCUUN3ME2wMlAxODF{ODFOwG0> NUi0[WJVW0GQR1XS
LAMA-84 NVLObohqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMECwNVY2KM7:TR?= NVK2cXJHW0GQR1XS
CGTH-W-1 M1jyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf2NZZKSzVyPUCuNFAyPjlizszN MWrTRW5ITVJ?
KASUMI-1 M4jxRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjp[|ZYUUN3ME2wMlAxOjF5IN88US=> NGPNbVhUSU6JRWK=
BE-13 NUGyS|hLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXSxUWxnUUN3ME2wMlAxOjV7IN88US=> NIDYWFdUSU6JRWK=
CTV-1 NV7WO2FvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEC1NlEh|ryP Mmn3V2FPT0WU
NKM-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfwUm5KSzVyPUCuNFA3PTVizszN NHvJPGxUSU6JRWK=
MONO-MAC-6 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj0TWM2OD1yLkCwPFM4KM7:TR?= MUfTRW5ITVJ?
A204 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlztTWM2OD1yLkCxNlE5KM7:TR?= NX3yfFk5W0GQR1XS
GDM-1 NUSycm9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;YTWlEPTB;MD6wNVg{OyEQvF2= MV7TRW5ITVJ?
AN3-CA NFOxNI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEG4O|Mh|ryP MnKxV2FPT0WU
BL-70 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\BT5FKSzVyPUCuNFIyQTlizszN MV;TRW5ITVJ?
Daudi NHPiTIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SwXWlEPTB;MD6wNlU{PyEQvF2= MoHBV2FPT0WU
KU812 NGLuVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXVZnFJUUN3ME2wMlAzQDR6IN88US=> M2nkVnNCVkeHUh?=
KG-1 NG\ZfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPRTWM2OD1yLkCzNlk1KM7:TR?= MonqV2FPT0WU
DOHH-2 MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLidJBKSzVyPUCuNFQ5ODNizszN NEiybm1USU6JRWK=
HuO9 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jTWM2OD1yLkC1OFQ5KM7:TR?= Mk[0V2FPT0WU
EB2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPmTWM2OD1yLkC1OVc3KM7:TR?= MmjjV2FPT0WU
G-402 NHiycFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwME[zOFEh|ryP M1zvV3NCVkeHUh?=
SU-DHL-1 MoXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLvUXBKSzVyPUCuNFY{PzlizszN NXS3NpRTW0GQR1XS
NCI-H719 NETDc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnYTWM2OD1yLkC3PFg5KM7:TR?= NFrscpNUSU6JRWK=
MLMA NXPGeHV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEmwOkDPxE1? NV32TVJ6W0GQR1XS
KM12 NG\GfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfncVFKSzVyPUCuNFk4OzdizszN NEXqfHdUSU6JRWK=
SUP-T1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHlTWM2OD1yLkC5PVgzKM7:TR?= NIr2ZW1USU6JRWK=
MZ1-PC NWnadIN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjNTWM2OD1yLkGxN|M3KM7:TR?= MoTzV2FPT0WU
MFE-296 M2rJc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMUG4N|kh|ryP NEDFNnJUSU6JRWK=
ALL-PO NWDmUId4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH2TnlKSzVyPUCuNVI1PDNizszN NF7QV2VUSU6JRWK=
GB-1 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TNRWlEPTB;MD6xNlUyOiEQvF2= Ml3uV2FPT0WU
SIG-M5 NWmzTWlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUOzO{DPxE1? MoPRV2FPT0WU
P30-OHK MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3sV5pKSzVyPUCuNVU3PzJizszN NEHU[HFUSU6JRWK=
NCI-H716 M17xRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMU[yOlYh|ryP M2fXWHNCVkeHUh?=
MPP-89 NVLzUIJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\pOWlEPTB;MD6xOlk{OyEQvF2= MmW5V2FPT0WU
SF126 NXPtfFNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfKdXA6UUN3ME2wMlE4ODZ|IN88US=> M1vDSnNCVkeHUh?=
CTB-1 NF3hRmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;0VGx6UUN3ME2wMlE4OzF4IN88US=> M1;SWXNCVkeHUh?=
CA46 M4rpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O4UmlEPTB;MD6xO|Q5QSEQvF2= NFXQblRUSU6JRWK=
NCI-H520 NELINlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfhTWM2OD1yLkG3O|MzKM7:TR?= MV;TRW5ITVJ?
CAL-85-1 M4LIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\SZmlEPTB;MD6xO|kzPyEQvF2= MoDDV2FPT0WU
NCI-H2342 NV;ZZlNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3KbZQyUUN3ME2wMlE5PTd5IN88US=> M2fJRnNCVkeHUh?=
697 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED0bGJKSzVyPUCuNVg5PzFizszN M{X5fXNCVkeHUh?=
NY NYDBenk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3TTWM2OD1yLkG5Nlg4KM7:TR?= NVnze|RDW0GQR1XS
T98G MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i1WWlEPTB;MD6xPVMyQCEQvF2= MYLTRW5ITVJ?
NCI-H1703 NFq3bGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInGTVlKSzVyPUCuNVk3OTVizszN MV3TRW5ITVJ?
NCI-H2087 NFrP[2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLvRY5KSzVyPUCuNlA1OzlizszN M37idXNCVkeHUh?=
PF-382 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMkC4O|Mh|ryP MXzTRW5ITVJ?
HCT-116 NIfiWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXqNJlKSzVyPUCuNlExPjlizszN MkjrV2FPT0WU
CAKI-1 MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMkG2OlYh|ryP M4H3WnNCVkeHUh?=
CCF-STTG1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\KXoZ6UUN3ME2wMlIzPDd3IN88US=> NGfTSWhUSU6JRWK=
D-392MG M3PEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf0TYFLUUN3ME2wMlI{OTd5IN88US=> NV\sRVNIW0GQR1XS
RT-112 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfSWJVKSzVyPUCuNlM4QTVizszN NIe3XVhUSU6JRWK=
MES-SA MnroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnyTWM2OD1yLkK0NVg4KM7:TR?= M2q4TXNCVkeHUh?=
LC-2-ad NVfNU|J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMkSyOlUh|ryP MYnTRW5ITVJ?
NOS-1 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMkSzOlch|ryP NIjhSlhUSU6JRWK=
NALM-6 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnoR|hKSzVyPUCuNlU2PDNizszN NX;SZlFYW0GQR1XS
TE-15 M3jYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfiVoF7UUN3ME2wMlI3ODlzIN88US=> NXTndIJ4W0GQR1XS
786-0 NHXVVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMk[yNlgh|ryP M{PNcnNCVkeHUh?=
IST-MES1 NYfuOFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTmNYlKSzVyPUCuNlY5OjlizszN MnXjV2FPT0WU
KYSE-180 MnHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnqdWNLUUN3ME2wMlI3QDlzIN88US=> M4PLO3NCVkeHUh?=
YT Ml\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDiZlJKSzVyPUCuNlY6PzRizszN M1jo[HNCVkeHUh?=
A427 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMkeyOlQh|ryP MmnhV2FPT0WU
KYSE-450 MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXwSlJ2UUN3ME2wMlI4OzJ7IN88US=> MXzTRW5ITVJ?
HuH-7 NF\BNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\jVHNIUUN3ME2wMlI4PzZ|IN88US=> M1zWTXNCVkeHUh?=
CAS-1 MlLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILEeZBKSzVyPUCuNlg{ODNizszN NYHHV2d{W0GQR1XS
KURAMOCHI NULwRmY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMki0NVkh|ryP Mmj2V2FPT0WU
ACHN NYm4UIR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLPeVZKSzVyPUCuNlk{OjNizszN M2PEcXNCVkeHUh?=
HGC-27 NWi0ZlZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXHTWM2OD1yLkK5N|U{KM7:TR?= MWjTRW5ITVJ?
A172 NXr0dWgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofmTWM2OD1yLkK5OVc4KM7:TR?= M{DvRXNCVkeHUh?=
SNU-449 Mkm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPUUGZKSzVyPUCuNlk6PjRizszN NWDzVJZIW0GQR1XS
SW982 M4\HU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXjWIpKSzVyPUCuNlk6PzhizszN MnuyV2FPT0WU
EFO-21 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L1VmlEPTB;MD6zNFQyOSEQvF2= MVrTRW5ITVJ?
NCI-H2030 NVi2[FlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj6Om84UUN3ME2wMlMyOTZ2IN88US=> MV;TRW5ITVJ?
HT-144 M4HlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvsOXBKSzVyPUCuN|EzQCEQvF2= MnmxV2FPT0WU
MFE-280 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O0TWlEPTB;MD6zNVQ2OyEQvF2= MX7TRW5ITVJ?
SK-LU-1 MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGi5ZY5KSzVyPUCuN|E1PjZizszN M3LscHNCVkeHUh?=
NCI-H2052 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K5R2lEPTB;MD6zNVQ5PCEQvF2= NV7hUHFlW0GQR1XS
SK-HEP-1 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XTSWlEPTB;MD6zN|M3QCEQvF2= NEfiNIdUSU6JRWK=
QIMR-WIL MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n6e2lEPTB;MD6zN|QzPCEQvF2= NELCToJUSU6JRWK=
A2780 NVPKd|VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KzXGlEPTB;MD6zOFMxPCEQvF2= MmfqV2FPT0WU
ACN MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwM{S4O|Mh|ryP MkKyV2FPT0WU
BxPC-3 M1nUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i3UGlEPTB;MD6zOFk5QSEQvF2= NFvjWJVUSU6JRWK=
BCPAP NUTqWm1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3rV4JTUUN3ME2wMlM3ODBzIN88US=> NV3WbHBOW0GQR1XS
HOP-62 NIGyUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorOTWM2OD1yLkO2NVA3KM7:TR?= MWPTRW5ITVJ?
SW1710 NVf5cWEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG1OHE4UUN3ME2wMlM3PDV3IN88US=> MX7TRW5ITVJ?
OPM-2 NXH5U2RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XFZWlEPTB;MD6zOlQ4OyEQvF2= MmDnV2FPT0WU
DBTRG-05MG MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLKNG5UUUN3ME2wMlM5ODV2IN88US=> MWfTRW5ITVJ?
SK-MEL-24 NF3IepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor4TWM2OD1yLkO5O|kyKM7:TR?= M2SzV3NCVkeHUh?=
8305C M4XYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLETWM2OD1yLkO5O|k{KM7:TR?= NGXpR41USU6JRWK=
OVCAR-4 NGnrN|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnp[4FvUUN3ME2wMlQyPTh4IN88US=> M1u2fnNCVkeHUh?=
HLE M3nqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLETWM2OD1yLkSxPFYh|ryP NF[zWmlUSU6JRWK=
NCI-H747 NFnOR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrP[FBzUUN3ME2wMlQzOTN5IN88US=> NHjvO3hUSU6JRWK=
SW780 M1TXTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mle0TWM2OD1yLkSyN|Q3KM7:TR?= NGC5OJVUSU6JRWK=
KYSE-150 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPhUWgxUUN3ME2wMlQzPDF3IN88US=> NWfW[HlVW0GQR1XS
H4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH61[G1KSzVyPUCuOFI1PTFizszN NYPOdnplW0GQR1XS
SW1088 M{fqZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwNESzPUDPxE1? MUjTRW5ITVJ?
SF268 M3vnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\uTWM2OD1yLkS0PFYh|ryP NGT4O4tUSU6JRWK=
RT4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwNEWxNVEh|ryP M{jJ[nNCVkeHUh?=
NCI-H522 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnv4TWM2OD1yLkS1Nlch|ryP M3ixeHNCVkeHUh?=
LCLC-97TM1 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HscGlEPTB;MD60OlE6PSEQvF2= M2LKSXNCVkeHUh?=
CAL-39 NYXmZXFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor3TWM2OD1yLkS2OVE6KM7:TR?= M4rkOnNCVkeHUh?=
CAL-120 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLlTHlKSzVyPUCuOFc3PDNizszN MoDpV2FPT0WU
ESS-1 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlziTWM2OD1yLkS3PFIyKM7:TR?= MVrTRW5ITVJ?
KARPAS-45 MmXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjhbW9jUUN3ME2wMlQ5QTN|IN88US=> NFzGNXJUSU6JRWK=
DU-4475 NW\ZU2k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLzTWM2OD1yLkS5OVEyKM7:TR?= NVT0cZdZW0GQR1XS
VMRC-RCZ NHjSVVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwNEm5NFQh|ryP Ml3DV2FPT0WU
HOS M1TQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXnZ|BKSzVyPUCuOVA{PjVizszN MYLTRW5ITVJ?
MOLT-16 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwNUG4NFgh|ryP MYPTRW5ITVJ?
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EHEB NEHS[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWxbWVPUUN3ME2wMlUzOTh{IN88US=> MkS3V2FPT0WU
MFH-ino MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:3Z2lEPTB;MD61NlM2OSEQvF2= NEGw[llUSU6JRWK=
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SW1417 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[1VndjUUN3ME2wMlUzPzhzIN88US=> MUPTRW5ITVJ?
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TE-12 NH\CcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ftbWlEPTB;MD61OVc{PSEQvF2= MVzTRW5ITVJ?
8-MG-BA MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwNU[wOVYh|ryP MUPTRW5ITVJ?
ECC12 NGXMeFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDoWIxVUUN3ME2wMlU3PTV6IN88US=> MXnTRW5ITVJ?
CHL-1 NXvN[GR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXNV|Z[UUN3ME2wMlU4PDZ|IN88US=> M1vwO3NCVkeHUh?=
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HPAF-II MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S1dWlEPTB;MD63O|UxOSEQvF2= M{LCXnNCVkeHUh?=
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NCI-H1755 M37LSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPTTWM2OD1yLkiwO|E1KM7:TR?= NFTGSmNUSU6JRWK=
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ETK-1 Mk\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnaXXlLUUN3ME2wMlgzPDRzIN88US=> MnXTV2FPT0WU
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NCI-H1581 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwOEmyPVch|ryP MXTTRW5ITVJ?
HuCCT1 NUD1cFNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHNd2NUUUN3ME2wMlg6PTR6IN88US=> MYjTRW5ITVJ?
BB30-HNC NX;4bJpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFG5OZRKSzVyPUCuPVI1PjlizszN MoTnV2FPT0WU
NCI-H2347 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3PTFdKSzVyPUCuPVMzQTJizszN M{T5NHNCVkeHUh?=
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NCI-H358 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHq0S2FKSzVyPUCuPVUxOTRizszN M1\VdXNCVkeHUh?=
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CAL-54 NVnX[ZYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwMEO5OVkh|ryP MXnTRW5ITVJ?
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U-266 M2LCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjJZ4c{UUN3ME2xMlA6PjN|IN88US=> NWrZOVVLW0GQR1XS
HT-1197 MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jqSWlEPTB;MT6xNVQ{QCEQvF2= NIHoSXNUSU6JRWK=
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MHH-NB-11 MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfXVVVJUUN3ME2xMlE2OzZ6IN88US=> NFXYXHhUSU6JRWK=
NCI-H2405 M2S1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DqNGlEPTB;MT6xOlE3KM7:TR?= NXnWRWtMW0GQR1XS
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ARH-77 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTFwMkK5NlQh|ryP M1T1TnNCVkeHUh?=
BHT-101 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLYTWM2OD1zLkKzOFkh|ryP MYXTRW5ITVJ?
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MKN28 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nS[mlEPTB;MT6yOVY{PiEQvF2= M1\vc3NCVkeHUh?=
KS-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnSNXdjUUN3ME2xMlI5OjZ7IN88US=> MlLZV2FPT0WU
NCI-H1734 NUK4[XJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nYc2lEPTB;MT6yPFkyOyEQvF2= MUHTRW5ITVJ?
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NCI-H838 NXnCVGdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFiwXXdKSzVyPUGuN|A3OTVizszN NIjLVGZUSU6JRWK=
HEC-1 NX\jNXMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;XOXRGUUN3ME2xMlM{PzV3IN88US=> M3zOd3NCVkeHUh?=
ME-180 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV2ze4ZrUUN3ME2xMlM4QTl|IN88US=> NIHCTlRUSU6JRWK=
MMAC-SF MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwM{m1PVUh|ryP MXvTRW5ITVJ?
IA-LM MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDReFJrUUN3ME2xMlQxQTF2IN88US=> MkPRV2FPT0WU
MN-60 NVjPS|g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHIOHRKSzVyPUGuOFMyOTRizszN M1PTOnNCVkeHUh?=
SIMA M4H3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT1bJZKSzVyPUGuOFg3QDdizszN NWC5[pVpW0GQR1XS
NCI-H1770 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu5UYJKSzVyPUGuOVIxPTRizszN M1ezZnNCVkeHUh?=
ONS-76 MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojUTWM2OD1zLkWyN|EyKM7:TR?= MkezV2FPT0WU
LB771-HNC MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjoTWM2OD1zLkWzPVA3KM7:TR?= MomwV2FPT0WU
SW48 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\4d3hrUUN3ME2xMlU1OjR|IN88US=> NYS0WZFlW0GQR1XS
KYSE-140 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjuUFZVUUN3ME2xMlU2PzRzIN88US=> NVr6XWlYW0GQR1XS
SW626 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nKTWlEPTB;MT61PFE3KM7:TR?= MoK2V2FPT0WU
MC-CAR NXPsRmluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fwSWlEPTB;MT61PFY3OyEQvF2= NHPhfpBUSU6JRWK=
D-336MG NFLwOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ixN2lEPTB;MT62Nlk1KM7:TR?= MmfMV2FPT0WU
SK-MEL-3 NFnob3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW1fJN1UUN3ME2xMlY{QTB{IN88US=> M{PiTHNCVkeHUh?=
MHH-PREB-1 M4jZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe2d2RbUUN3ME2xMlY1PDd|IN88US=> MknqV2FPT0WU
Calu-1 NVzScIc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHaTWM2OD1zLk[1N|g3KM7:TR?= NWG2d|R6W0GQR1XS
HCC1806 NX33SoRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7WO49nUUN3ME2xMlY3PjFzIN88US=> M1vSVnNCVkeHUh?=
A101D MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDJRYw3UUN3ME2xMlY3PzhzIN88US=> NViyblBWW0GQR1XS
A704 Mn;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT5c4tTUUN3ME2xMlY5OzFzIN88US=> NHzaXJhUSU6JRWK=
LB831-BLC M3zteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[1emRvUUN3ME2xMlY6QDV2IN88US=> M2X1VHNCVkeHUh?=
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RPMI-2650 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fPdWlEPTB;MT63NlcyQSEQvF2= NFn6UlZUSU6JRWK=
NH-12 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;hTWM2OD1zLkezOFI4KM7:TR?= M3HpNXNCVkeHUh?=
AGS M{\3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknGTWM2OD1zLke2N|U5KM7:TR?= MlzuV2FPT0WU
NEC8 MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7tTWM2OD1zLke4PVk2KM7:TR?= MmHtV2FPT0WU
NCI-H2009 NWn6WFR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[1PWlEPTB;MT63PVczOSEQvF2= NH72XXRUSU6JRWK=
A498 M2WxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTFwOEGyPFIh|ryP MWnTRW5ITVJ?
NCI-H810 M{T1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwOEG2NFYh|ryP NFz6fFBUSU6JRWK=
SK-NEP-1 NWPO[nhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFwOEO3Olch|ryP NWq3[GI6W0GQR1XS
D-542MG MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTFwOEW4OVEh|ryP NWLUN2NCW0GQR1XS
KNS-42 NXTEPXFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TKXGlEPTB;MT64OlI3PiEQvF2= NH3wXoZUSU6JRWK=
NCI-H2452 NE\oWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TYOWlEPTB;MT64PVA4PCEQvF2= NWrVZmFpW0GQR1XS
SK-MEL-2 M4TYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3GPIJKSzVyPUGuPVAzPzFizszN MnXYV2FPT0WU
OVCAR-5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWzdFJnUUN3ME2xMlkxPjd3IN88US=> NInJRlZUSU6JRWK=
SNG-M NYfXUlFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXURXlEUUN3ME2xMlk2QDV6IN88US=> NV7aUWRHW0GQR1XS
A673 M3PPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFwOUe1NVYh|ryP Mn\PV2FPT0WU
L-428 NVzhWHNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Lqd2lEPTB;MT65PVE4QSEQvF2= MWPTRW5ITVJ?
KM-H2 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjjeHdKSzVyPUKuNFExQSEQvF2= NHTtSnZUSU6JRWK=
MC-IXC NH\mfYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;PXmlEPTB;Mj6wNlI4OyEQvF2= MVXTRW5ITVJ?
COLO-678 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL4fGNPUUN3ME2yMlA1OjB5IN88US=> NYjxdWR{W0GQR1XS
MEL-JUSO M3vY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwMEe4OVEh|ryP MVnTRW5ITVJ?
HCC38 NVPJcYI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTCR25KSzVyPUKuNFg1OzNizszN NIH1[lhUSU6JRWK=
UACC-62 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH6eZJCUUN3ME2yMlA5QDV3IN88US=> NYn0SGxlW0GQR1XS
OAW-42 M{XMd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrnXJZKSzVyPUKuNFk4OTFizszN NXLubW04W0GQR1XS
LB996-RCC NGq4VIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfqTWM2OD1{LkGzPFE4KM7:TR?= MVvTRW5ITVJ?
COR-L105 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7QN3ZKSzVyPUKuNVY{PzNizszN MnTRV2FPT0WU
RCC10RGB NHjTVodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXr5[lNmUUN3ME2yMlE5PTd4IN88US=> MlnyV2FPT0WU
A431 NHrOfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJwMUmwNVkh|ryP NHL6UolUSU6JRWK=
NCI-H292 NGG4d5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\wTWM2OD1{LkKzPVUyKM7:TR?= NGHsOGtUSU6JRWK=
SK-UT-1 NWDQXHhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwM{OxPFQh|ryP NGn3bJZUSU6JRWK=
PANC-08-13 NWjaTGxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17vcWlEPTB;Mj6zN|I{PSEQvF2= MkjLV2FPT0WU
ST486 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfLSWFpUUN3ME2yMlQyODR6IN88US=> MVfTRW5ITVJ?
SJSA-1 M3P0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTJwNEGyO|Eh|ryP NGnQcHhUSU6JRWK=
RKO NFjaeWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DydmlEPTB;Mj60NlAzQSEQvF2= NUXqVZVEW0GQR1XS
NCI-H1793 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPpToJOUUN3ME2yMlQ1ODJ7IN88US=> NEPR[GhUSU6JRWK=
639-V Mln3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfjTWM2OD1{LkS1N|gzKM7:TR?= Mln1V2FPT0WU
ES3 M1ezTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSyZ|FxUUN3ME2yMlQ6PzN5IN88US=> NV3FOZFZW0GQR1XS
NCI-H1792 M1HTVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJwNU[4NlYh|ryP NW\1OJlCW0GQR1XS
NCI-H1651 NHfTeWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknjTWM2OD1{LkW4NlEh|ryP NVnqZ|V6W0GQR1XS
SN12C NIDUNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe1[25KSzVyPUKuOVg1QDdizszN NYH2XJlZW0GQR1XS
COLO-679 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\jW2lEPTB;Mj61PFYxPSEQvF2= NU\HV4VZW0GQR1XS
U-118-MG MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HsUmlEPTB;Mj61PFg4OiEQvF2= MWPTRW5ITVJ?
Ramos-2G6-4C10 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mni5TWM2OD1{Lk[0PFA4KM7:TR?= MUHTRW5ITVJ?
HCT-15 NH:3NplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\kUGlEPTB;Mj62PFc6OiEQvF2= NInrV4ZUSU6JRWK=
MDA-MB-157 M4H5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DWRWlEPTB;Mj63NFc1PyEQvF2= MYTTRW5ITVJ?
K5 NIe1OoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[4TWM2OD1{LkexPFQ2KM7:TR?= NVLYNXluW0GQR1XS
MKN45 Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHMS5V2UUN3ME2yMlc{OzZ4IN88US=> Mn[yV2FPT0WU
DMS-273 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwN{W2N|Ih|ryP NEDHZZRUSU6JRWK=
C8166 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJwN{i1NVMh|ryP NXrZSXhSW0GQR1XS
Calu-3 NY\ISmlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJwN{i5Olkh|ryP M17Td3NCVkeHUh?=
SNB75 NVXOPYp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXNfWpKSzVyPUKuPFg2OzVizszN M17vNnNCVkeHUh?=
BFTC-905 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7RPW5KSzVyPUKuPVAyQTFizszN MVXTRW5ITVJ?
C-4-II NXT2bWtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjxW4d5UUN3ME2yMlkyOzV|IN88US=> M2q5WHNCVkeHUh?=
MS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf1SHhbUUN3ME2yMlk3PzZ7IN88US=> M1nE[XNCVkeHUh?=
A375 NV;QOVg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L2NWlEPTB;Mz6wPFE5PCEQvF2= NX7JW5VjW0GQR1XS
KYSE-70 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTNwMEi4PFIh|ryP NWjCeG5SW0GQR1XS
KYSE-510 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHzb3lKSzVyPUOuNVA6QTVizszN MmPjV2FPT0WU
LN-405 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jGO2lEPTB;Mz6xN|UyQCEQvF2= MlzpV2FPT0WU
BOKU MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe1XWRKSzVyPUOuNVQzPTZizszN MVXTRW5ITVJ?
TE-10 NHf6dmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILmVIdKSzVyPUOuNVc{PjJizszN Mo[1V2FPT0WU
MKN1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rreWlEPTB;Mz6xPFQ5OyEQvF2= MUTTRW5ITVJ?
M059J NILzbIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq2boJKSzVyPUOuNlAyPzNizszN M1rve3NCVkeHUh?=
GOTO MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjwXGRpUUN3ME2zMlIzODN7IN88US=> NXflZZhXW0GQR1XS
DK-MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr5TWM2OD1|LkK1PVc3KM7:TR?= MnXJV2FPT0WU
NCI-H727 NV;MPJVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfyT4VKSzVyPUOuNlY2QCEQvF2= NHHhRndUSU6JRWK=
NB12 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\tTWM2OD1|LkOzNlI1KM7:TR?= MXvTRW5ITVJ?
DOK MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmzTYpKSzVyPUOuN|YyQDZizszN MYXTRW5ITVJ?
KYSE-410 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHoTWM2OD1|LkO2Nlg4KM7:TR?= NGPnZ25USU6JRWK=
AM-38 M{foS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jocWlEPTB;Mz6zPFA2OSEQvF2= Mmf6V2FPT0WU
GR-ST M4j5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVS5O4hGUUN3ME2zMlQ2PzN{IN88US=> NETiU3BUSU6JRWK=
D-247MG NV;KPZV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwNEiyOlMh|ryP NXTQelFxW0GQR1XS
TE-8 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnPZpBKSzVyPUOuOFk{OzNizszN M4rrS3NCVkeHUh?=
LS-411N NXyyU4RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLaOHlqUUN3ME2zMlQ6Pjl{IN88US=> MoLNV2FPT0WU
SK-MES-1 NUOxWphnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jNRmlEPTB;Mz61OlQ{OyEQvF2= Mle1V2FPT0WU
SF295 NEXjUXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37iWGlEPTB;Mz62NVU2OiEQvF2= NH;EeI1USU6JRWK=
SK-MEL-30 M3;nU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnqyTWM2OD1|Lk[1PVIyKM7:TR?= Mlm0V2FPT0WU
LB2241-RCC M1nUO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrDWWwyUUN3ME2zMlY3OjZizszN MV;TRW5ITVJ?
PC-14 NVLGcGh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PkXmlEPTB;Mz62OlQ{PyEQvF2= M2HrVHNCVkeHUh?=
EW-7 M37ubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXnVJJGUUN3ME2zMlY4Pjl|IN88US=> NFfER5BUSU6JRWK=
NMC-G1 NVnCNZR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DPc2lEPTB;Mz63NVg{PyEQvF2= M1PTeXNCVkeHUh?=
TE-441-T Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DIdGlEPTB;Mz63N|AzQCEQvF2= Mm\SV2FPT0WU
NCI-H1618 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DqWmlEPTB;Mz64NVg4PSEQvF2= M{npZ3NCVkeHUh?=
PANC-03-27 M3Pse2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TPOWlEPTB;Mz64NVkyPiEQvF2= M3HJcHNCVkeHUh?=
NCI-H2228 NEHiOI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO3TWM2OD1|LkizNVI3KM7:TR?= M{nMW3NCVkeHUh?=
CAPAN-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke0TWM2OD1|Lki3NFA6KM7:TR?= NIPDV2dUSU6JRWK=
KLE NHHVXHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH1TWM2OD1|LkmwOlch|ryP NF7EXY1USU6JRWK=
Becker M2WzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPI[XlKSzVyPUOuPVI5PDlizszN MVnTRW5ITVJ?
SK-PN-DW MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7NNWsxUUN3ME20MlA4QTd2IN88US=> M4fIUXNCVkeHUh?=
Hs-578-T M1\YUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S1W2lEPTB;ND6wPFMxPiEQvF2= NVjke5dkW0GQR1XS
RS4-11 Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjFN|RKSzVyPUSuNVEzPTVizszN NHXSN|NUSU6JRWK=
D-502MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTyfo5ZUUN3ME20MlE3QTl5IN88US=> Mn:5V2FPT0WU
GI-1 NUS3N4h2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlOzTWM2OD12LkK4Nlk6KM7:TR?= M{TsS3NCVkeHUh?=
NCI-H209 NVL5cY5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHMbGlVUUN3ME20MlM{PzhizszN M1u0OXNCVkeHUh?=
SK-OV-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWG5OmE2UUN3ME20MlQ5OTR7IN88US=> NEjvd3dUSU6JRWK=
LOUCY NYexcpV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzKTWM2OD12LkS4OFMzKM7:TR?= NVvuZpNYW0GQR1XS
NCI-H69 MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLFS4tbUUN3ME20MlUyPzl|IN88US=> NYDzTnJOW0GQR1XS
SCC-9 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTRwNUOxO|Ih|ryP NFGxOWpUSU6JRWK=
NCI-H526 NHO1dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfjcIpKSzVyPUSuOVkzQTNizszN NXvxbWw4W0GQR1XS
NCI-H2170 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXJToFKSzVyPUSuOlY4PzFizszN MXPTRW5ITVJ?
SR NGmzN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjWTYxKSzVyPUSuO|AxPDhizszN NIHmW4VUSU6JRWK=
CMK Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XaWWlEPTB;ND63NlExOSEQvF2= NF3NVGFUSU6JRWK=
COLO-829 NW\Ebm9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnCWlFMUUN3ME20Mlc4ODR|IN88US=> M1PQfnNCVkeHUh?=
HuO-3N1 M17MSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vxSWlEPTB;ND64N|I5OSEQvF2= Mo\EV2FPT0WU
5637 NHj5d4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTRwOUC0PFch|ryP MnuyV2FPT0WU
A253 NF[4cJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHPemJKSzVyPUSuPVc4ODhizszN NFTr[JlUSU6JRWK=
NB10 M4fu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnO0TWM2OD13LkC3OFk4KM7:TR?= NUHwTopbW0GQR1XS
SF539 MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPOTWM2OD13LkC5PVU6KM7:TR?= Mkf6V2FPT0WU
HAL-01 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTVwMUS2OFUh|ryP M2jtT3NCVkeHUh?=
MHH-ES-1 M{TRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLiTWM2OD13LkG2PVI2KM7:TR?= MnjxV2FPT0WU
DEL MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\6TWM2OD13LkK3OVgzKM7:TR?= NVzv[lJWW0GQR1XS
NCI-H1299 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[0SIhKSzVyPUWuN|UxODdizszN MnHIV2FPT0WU
ChaGo-K-1 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTVwM{WxNFch|ryP NFizV4tUSU6JRWK=
HMV-II MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ziXmlEPTB;NT6zPVQ{KM7:TR?= Ml3EV2FPT0WU
NB69 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHQTWM2OD13LkO5OlMyKM7:TR?= NVHweo1EW0GQR1XS
NCI-H1882 M4S4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\WSoRKSzVyPUWuOFM{PjRizszN MnTwV2FPT0WU
SNU-475 NYGxdZhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PZUmlEPTB;NT60O|E4OSEQvF2= M3fpV3NCVkeHUh?=
RXF393 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX0eFBzUUN3ME21MlQ5PDl2IN88US=> NXLQNYtZW0GQR1XS
CAL-51 MmS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzXWodYUUN3ME21MlYzQDV|IN88US=> MlXuV2FPT0WU
SW1573 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfTVHE3UUN3ME21MlY{PTN2IN88US=> M3Xpe3NCVkeHUh?=
GCT MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HRUGlEPTB;NT63OVkzQSEQvF2= NI\3T2NUSU6JRWK=
COR-L88 M4S3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLD[ZBKSzVyPUWuO|Y5PDZizszN NWrwUZdSW0GQR1XS
MDA-MB-134-VI NWTTUG16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTVwOEe1N|Yh|ryP NEKxXJFUSU6JRWK=
NB5 NHnHNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\qTWM2OD13LkmyOFQh|ryP NHjUe|ZUSU6JRWK=
GMS-10 NIDiRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e4[2lEPTB;NT65Olg3OSEQvF2= NF\FTHRUSU6JRWK=
CHP-212 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonKTWM2OD14LkS4NlY4KM7:TR?= Mmj5V2FPT0WU
TE-11 MlXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTrTWM2OD14LkW1NVgzKM7:TR?= NFnXUY5USU6JRWK=
SW962 Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvG[GRrUUN3ME22MlY2Pzd2IN88US=> NX\MSXV{W0GQR1XS
MZ2-MEL NGXlcnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLKTWM2OD14LkiyNFEyKM7:TR?= NF62NWhUSU6JRWK=
C-33-A MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHRTWM2OD14LkmxOlg5KM7:TR?= NX[5e5pTW0GQR1XS
IGR-1 M2ruZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTDTWM2OD14Lkm3PFI3KM7:TR?= MYXTRW5ITVJ?
MOLT-4 M1z6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TYNmlEPTB;Nz6xOVQxPiEQvF2= M{XXSXNCVkeHUh?=
NCI-H1650 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF20UINKSzVyPUeuNlcxPDZizszN M3TRU3NCVkeHUh?=
AsPC-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTdwMki2NFUh|ryP MmP4V2FPT0WU
SNU-C2B M1vWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTdwMkm1O|Eh|ryP Ml\iV2FPT0WU
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T84 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLLTWM2OD1{MT65PFE6KM7:TR?= NVfpV25IW0GQR1XS
NCI-H630 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPU[pBSUUN3ME2yNk42OzZ|IN88US=> MnXYV2FPT0WU
LU-165 NFTL[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknBTWM2OD1{Mj61OVQh|ryP MWnTRW5ITVJ?
COLO-792 M2e2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnCN|E{UUN3ME2yNk44OTFzIN88US=> NGrJUWVUSU6JRWK=
CAL-62 NVjrSmxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[3TWM2OD1{Mj63OVE4KM7:TR?= MWnTRW5ITVJ?
HCE-T MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLLUVJKSzVyPUKyMlg3ODZizszN MUHTRW5ITVJ?
BB65-RCC NVnwWnpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\JN2lEPTB;MkOuNFM1PCEQvF2= NEHSR|ZUSU6JRWK=
SiHa MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzkTWM2OD1{Mz6zPVY5KM7:TR?= NUf4Xnk3W0GQR1XS
NCI-H2081 MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ2LkC2OFEh|ryP MoXiV2FPT0WU
U251 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\IT2lEPTB;MkSuNFY3QCEQvF2= NFX0RpVUSU6JRWK=
LoVo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC0TWM2OD1{ND65NlgzKM7:TR?= NWHpc|BHW0GQR1XS
GCIY MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnxRoVnUUN3ME2yOU4zQDd5IN88US=> MnjUV2FPT0WU
NUGC-3 M1LJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17hSWlEPTB;MkWuN|MyPiEQvF2= MmWxV2FPT0WU
LNCaP-Clone-FGC M3XWVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ3LkO0PVgh|ryP NH7PTGhUSU6JRWK=
PA-1 Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXjbVRKSzVyPUK1MlY5OzNizszN NGLrbllUSU6JRWK=
OE33 M2H6Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHITWM2OD1{NT62PFU{KM7:TR?= NF7NO2RUSU6JRWK=
HT-29 NGe4elRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ3Lke4O|kh|ryP NYfhWGZVW0GQR1XS
RCM-1 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rkZ2lEPTB;MkWuPVY2PiEQvF2= MULTRW5ITVJ?
NCI-H1522 NFvjTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TJOmlEPTB;MkWuPVkyOSEQvF2= NV\GZ3pwW0GQR1XS
LB373-MEL-D NG\pPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nDdGlEPTB;Mk[uNVcxQCEQvF2= M3nqWnNCVkeHUh?=
NCI-H1436 NUO4N2hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDITWM2OD1{Nj6yO|M5KM7:TR?= M1zDc3NCVkeHUh?=
COLO-824 M{fP[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjQTWM2OD1{Nj60NFAzKM7:TR?= MYXTRW5ITVJ?
CP50-MEL-B M4qzPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ4LkW2O|Uh|ryP M{XUNXNCVkeHUh?=
EGI-1 NHTvOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;qTWM2OD1{Nz6yOlk5KM7:TR?= M{Ha[XNCVkeHUh?=
LAN-6 NWDqbmpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiwc5VXUUN3ME2yO{4{PTl6IN88US=> M4HOcXNCVkeHUh?=
GAK M4TCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjzXmpKSzVyPUK3MlQzOjVizszN M2HWZXNCVkeHUh?=
MDA-MB-175-VII NXfpUI9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHvTWM2OD1{Nz61NFU{KM7:TR?= NVPLeYJYW0GQR1XS
JVM-2 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS2OXFKSzVyPUK3MlY3OjJizszN MkLjV2FPT0WU
UACC-257 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2m1XGlEPTB;MkeuOlg4QCEQvF2= NF\FUFlUSU6JRWK=
SW1783 NHToTWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XvbGlEPTB;MkeuO|c5OyEQvF2= M3zsXXNCVkeHUh?=
HT-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe0eYhFUUN3ME2yPE4zOTZ4IN88US=> MYHTRW5ITVJ?
RL MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjxVHpKSzVyPUK4MlU6OTFizszN MYXTRW5ITVJ?
TK10 NGjZUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r1[GlEPTB;MkiuOlU{PSEQvF2= M4HjOHNCVkeHUh?=
HT55 NGT4Wo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\zVGJKSzVyPUK5MlA2PjVizszN NFzGNWtUSU6JRWK=
BT-20 MmP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHycWFKSzVyPUK5MlA2QDZizszN NIPre5hUSU6JRWK=
TGBC24TKB NWG0do1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPXZ2ZKSzVyPUK5MlE5OzFizszN NFm3c3VUSU6JRWK=
HSC-2 MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDKTWM2OD1{OT6zNFAyKM7:TR?= M1\KOHNCVkeHUh?=
COLO-205 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jHfGlEPTB;MkmuN|k1PCEQvF2= Mn\1V2FPT0WU
GT3TKB M3\tRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ7Lk[4O|ch|ryP MWXTRW5ITVJ?
T47D NIPxNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfsTWM2OD1{OT64OVgzKM7:TR?= M{TBfXNCVkeHUh?=
OMC-1 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTNyLkG5NVkh|ryP MWfTRW5ITVJ?
PFSK-1 NIHRcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNzLkK2OVkh|ryP MkXnV2FPT0WU
JEG-3 NX[2WlZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvieZlKSzVyPUOxMlM2PjFizszN NV;LV3o1W0GQR1XS
RD NEHnV|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e5W2lEPTB;M{GuOVEyPSEQvF2= MoSyV2FPT0WU
NCI-H64 NEHFS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnaTWM2OD1|Mj60NVc6KM7:TR?= NYfqOnhZW0GQR1XS
DMS-114 M2\3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX2TWM2OD1|Mj60NVgzKM7:TR?= NG\Md5NUSU6JRWK=
NCI-H661 M1XJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCyUHFKSzVyPUOyMlY2ODFizszN NVj6cHdxW0GQR1XS
CAL-148 NETkNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7TeplKSzVyPUOyMlY3PjVizszN M1mxeHNCVkeHUh?=
HuP-T3 NXXNR5J1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTN{LkmzN|gh|ryP MX\TRW5ITVJ?
ES4 NH7n[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHS0dplKSzVyPUOzMlE4ODVizszN NFrEfXZUSU6JRWK=
Ca9-22 MoXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO4Wm9KSzVyPUOzMlQ3ODFizszN NYT0e|hSW0GQR1XS
LP-1 NWXZWGN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3jOYRKSzVyPUO0MlA6KM7:TR?= NHfDS2ZUSU6JRWK=
AU565 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjIeppKSzVyPUO0MlUxPjlizszN M2PET3NCVkeHUh?=
MDA-MB-453 NVTYS3ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfmWZVbUUN3ME2zOU4yPDJ4IN88US=> NWHS[o9ZW0GQR1XS
SNU-C1 MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPTcVhKSzVyPUO1MlE4OSEQvF2= MUDTRW5ITVJ?
SW13 MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPlSXljUUN3ME2zOU41ODd4IN88US=> M{nNOnNCVkeHUh?=
NCI-H2122 M3TaPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHaZZRKSzVyPUO1MlU2QThizszN NVvxcoFUW0GQR1XS
NCI-H1395 M{TGOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TUT2lEPTB;M{WuOlY6OSEQvF2= NWXLdZNOW0GQR1XS
J-RT3-T3-5 NX3MSYdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;WTWM2OD1|Nj6wNlk1KM7:TR?= NITrcYtUSU6JRWK=
COR-L279 NHSzcY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLCdHB2UUN3ME2zOk4yQThzIN88US=> MVrTRW5ITVJ?
ATN-1 NIHjfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojzTWM2OD1|Nj64OVE3KM7:TR?= Mnj6V2FPT0WU
HCC2998 NWPXVYtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TGbGlEPTB;M{[uPFU4OSEQvF2= NYTHXVhDW0GQR1XS
UM-UC-3 NVLodFdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33rOmlEPTB;M{[uPFY4PSEQvF2= M2PZUXNCVkeHUh?=
DV-90 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUewdGhZUUN3ME2zOk46ODZ5IN88US=> MUXTRW5ITVJ?
ES8 NX24bpp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2X5d2lEPTB;M{[uPVMyQCEQvF2= NXPqZmd7W0GQR1XS
YAPC M2rC[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTN4Lkm2OVQh|ryP MWPTRW5ITVJ?
HCC1599 M4fZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYO4[FBZUUN3ME2zO{4yPjF6IN88US=> Mn34V2FPT0WU
UMC-11 M{W4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7iRVE2UUN3ME2zO{4zPTB|IN88US=> MXzTRW5ITVJ?
THP-1 NV\jPXlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr4OVlKSzVyPUO3MlI5PjhizszN MUTTRW5ITVJ?
OCUB-M NV\SWJE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN5LkK4PVEh|ryP MYrTRW5ITVJ?
NCI-H1693 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLITppKSzVyPUO3MlMzOzNizszN NVL2VpIzW0GQR1XS
NCI-H345 MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTN5LkO2NlQh|ryP NIC1dIlUSU6JRWK=
COLO-800 NH\u[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTN5LkW2O{DPxE1? M4HneXNCVkeHUh?=
COLO-320-HSR NE\a[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTN6LkO0PVIh|ryP NV\2fJdVW0GQR1XS
NCI-H596 MkLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX61RYcyUUN3ME2zPE41PDh7IN88US=> NF;LbWdUSU6JRWK=
NCI-H187 NVnnZ|ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTN6LkezOFQh|ryP M{XIV3NCVkeHUh?=
ECC4 NULDSVVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES1dG9KSzVyPUO5MlA5OTRizszN MWTTRW5ITVJ?
KP-4 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf5RVRNUUN3ME2zPU4yOjN3IN88US=> M{nSdXNCVkeHUh?=
NCI-H2227 M1jpTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTN7LkO5OFkh|ryP M3XuZnNCVkeHUh?=
22RV1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPiTWM2OD1|OT64N|k5KM7:TR?= NGDSPFJUSU6JRWK=
SAS NIPLb5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPWXZptUUN3ME20NE4xQTZizszN NEnJdXdUSU6JRWK=
PANC-10-05 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWqyNFlUUUN3ME20NE4yQDJ6IN88US=> NEfUPWtUSU6JRWK=
MDA-MB-468 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnSwTWM2OD12MD61N|Q3KM7:TR?= M1L6RXNCVkeHUh?=
RPMI-7951 M1:zN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPkTJl2UUN3ME20NU4zODd3IN88US=> NX3h[Zh5W0GQR1XS
BB49-HNC NUX4ZmQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTrfJBOUUN3ME20NU4zOTd7IN88US=> NVr2PFJIW0GQR1XS
23132-87 NW\l[GVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTRzLkK3N|Ih|ryP M2C1ZXNCVkeHUh?=
HCC1569 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTRzLkK4PFUh|ryP MmLCV2FPT0WU
CP66-MEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W1ZmlEPTB;NEKuNVg5PiEQvF2= M{\BSXNCVkeHUh?=
K-562 MoiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjNU3VKSzVyPUSyMlI5PTRizszN NYjub5Q5W0GQR1XS
OCI-AML2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfBTWM2OD12Mj64PVc1KM7:TR?= MX\TRW5ITVJ?
SW756 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR|LkCzPFgh|ryP NHTXXmlUSU6JRWK=
M14 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofsTWM2OD12Mz6zNVg6KM7:TR?= NXzRUmlFW0GQR1XS
NCI-H1623 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHkTWM2OD12Mz60OlQh|ryP NXfRNlJ2W0GQR1XS
KNS-81-FD M4f4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PuU2lEPTB;NEOuO|YzKM7:TR?= M2rBRXNCVkeHUh?=
TGBC1TKB MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r6dWlEPTB;NEOuPVA6QSEQvF2= NEjTUlBUSU6JRWK=
RERF-LC-MS NV3ve3RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTR|LkmyPFEh|ryP Mly2V2FPT0WU
PC-3 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zwcWlEPTB;NESuOFM1PyEQvF2= MmfwV2FPT0WU
HuP-T4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILNeVdKSzVyPUS0MlQ1PzRizszN M2S4enNCVkeHUh?=
NCI-H510A NITQO2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi0TWM2OD12ND63NFgh|ryP NXfkcnhEW0GQR1XS
LB2518-MEL M1H2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR2Lke5N|ch|ryP NFP0TpBUSU6JRWK=
TE-5 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLYTWM2OD12NT65OVgyKM7:TR?= M{PmenNCVkeHUh?=
EW-24 MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTR4LkG3NlMh|ryP M2nhe3NCVkeHUh?=
LB647-SCLC MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH6TWM2OD12Nj6yNVU2KM7:TR?= MmLKV2FPT0WU
NCI-H524 NIfyeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfoW|FzUUN3ME20Ok44OTh3IN88US=> NVPNcJdoW0GQR1XS
EW-11 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjrTWM2OD12Nj65N|c{KM7:TR?= MmHJV2FPT0WU
KALS-1 MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTCZ4hKSzVyPUS3MlIxPjZizszN NV;zWXBxW0GQR1XS
BT-474 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvMOYxKSzVyPUS3MlQzOTZizszN M{L3VXNCVkeHUh?=
SK-N-AS MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTR5Lki4PEDPxE1? MW\TRW5ITVJ?
HCC2157 NVjROI55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu1TWM2OD12OD6wO|Yh|ryP NEHYZVFUSU6JRWK=
HCC1954 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTR6LkG3NFQh|ryP MYrTRW5ITVJ?
FADU NXm4UHRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr1dWpKSzVyPUS4MlMxOzFizszN MWLTRW5ITVJ?
S-117 NHvOc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO1bpZKSzVyPUS4MlM5OTVizszN NFLsR2hUSU6JRWK=
LS-1034 NFn0N5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGSyR5lKSzVyPUS4MlcxPjdizszN NXL4b3pIW0GQR1XS
CAMA-1 NHr4c4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjtTWM2OD12OT61OVQ{KM7:TR?= M2GxTnNCVkeHUh?=
LU-134-A MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX5SoVKSzVyPUS5MlgxQDVizszN NEXrfmFUSU6JRWK=
NCI-H1838 M1\BVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR7LkiwPFch|ryP NUK4VVFNW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2
NCT01874665 Completed GIST Ariad Pharmaceuticals|Takeda June 5 2013 Phase 2
NCT01424982 Recruiting Acute Lymphoblastic Leukemia|Adult Acute Lymphoblastic Leukemia in Complete Remission|B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|Philadelphia Chromosome Positive|Untreated Adult Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) October 5 2011 Phase 2
NCT02627677 Active not recruiting Chronic Phase Chronic Myeloid Leukemia Ariad Pharmaceuticals|Takeda December 31 2015 Phase 3
NCT01667133 Completed Chronic Myeloid Leukemia (CML)|Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Ariad Pharmaceuticals|Takeda August 31 2012 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID