Ponatinib (AP24534)

For research use only.

Catalog No.S1490

95 publications

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.

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Selleck's Ponatinib (AP24534) has been cited by 95 publications

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Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NGG0N4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvVTWM2OD1yLkCwNFAxODB|NUmg{txO NWnhWGdKW0GQR1XS
MV-4-11 NF:yZZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rTSWlEPTB;MD6wNFAxQTV4IN88US=> MU\TRW5ITVJ?
MEG-01 NHfV[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrON2lKSzVyPUCuNFAxOTJ6IN88US=> NYPlOHhYW0GQR1XS
LAMA-84 NWHtN5E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHlOFk{UUN3ME2wMlAxODF4NTFOwG0> MkH3V2FPT0WU
CGTH-W-1 NWXFbWpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfrZ4lKSzVyPUCuNFAyPjlizszN NVjTU2w3W0GQR1XS
KASUMI-1 NXzSdmk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f5fWlEPTB;MD6wNFIyPyEQvF2= NHr2bYJUSU6JRWK=
BE-13 NF\x[m9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLKTWM2OD1yLkCwNlU6KM7:TR?= NFvDOnpUSU6JRWK=
CTV-1 M1HPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fOWGlEPTB;MD6wNFUzOSEQvF2= M3vMSXNCVkeHUh?=
NKM-1 M3jWUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEC2OVUh|ryP NFiwZnBUSU6JRWK=
MONO-MAC-6 MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHIc4pKSzVyPUCuNFA5OzdizszN M{XaUXNCVkeHUh?=
A204 NV\NN2VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDTTWM2OD1yLkCxNlE5KM7:TR?= Mkj2V2FPT0WU
GDM-1 NFr4fnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEG4N|Mh|ryP Mn7ZV2FPT0WU
AN3-CA M4rJTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSzS4RDUUN3ME2wMlAyQDd|IN88US=> NYCwVWxwW0GQR1XS
BL-70 NIjLNFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEKxPVkh|ryP MUDTRW5ITVJ?
Daudi MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jLcWlEPTB;MD6wNlU{PyEQvF2= NV3RZnpQW0GQR1XS
KU812 M{P1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEK4OFgh|ryP NGTufZBUSU6JRWK=
KG-1 NFnZOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDpWlZKSzVyPUCuNFMzQTRizszN M1nxfXNCVkeHUh?=
DOHH-2 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMES4NFMh|ryP NEXmS5pUSU6JRWK=
HuO9 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHySVBmUUN3ME2wMlA2PDR6IN88US=> MlXDV2FPT0WU
EB2 NHnteGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ZV21KSzVyPUCuNFU2PzZizszN NIO0bplUSU6JRWK=
G-402 NFzU[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HjZ2lEPTB;MD6wOlM1OSEQvF2= MkDpV2FPT0WU
SU-DHL-1 NIOycnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO4[ohKSzVyPUCuNFY{PzlizszN MV7TRW5ITVJ?
NCI-H719 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnR[YF4UUN3ME2wMlA4QDh6IN88US=> MoKwV2FPT0WU
MLMA M17CTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu3bHdKSzVyPUCuNFkxPiEQvF2= NXf1RWFIW0GQR1XS
KM12 M{O5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PSO2lEPTB;MD6wPVc{PyEQvF2= M{fTVHNCVkeHUh?=
SUP-T1 MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\HTIl5UUN3ME2wMlA6QTh{IN88US=> NUfvPVBpW0GQR1XS
MZ1-PC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vBWWlEPTB;MD6xNVM{PiEQvF2= MWLTRW5ITVJ?
MFE-296 NGXSZ5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLCTWM2OD1yLkGxPFM6KM7:TR?= MnTOV2FPT0WU
ALL-PO NVu5epE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfDeI5KSzVyPUCuNVI1PDNizszN NUHwO|E6W0GQR1XS
GB-1 NXHVfWJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTv[IJGUUN3ME2wMlEzPTF{IN88US=> NV21WVZHW0GQR1XS
SIG-M5 NVfidm1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq3RmZjUUN3ME2wMlE{OzdizszN MoPVV2FPT0WU
P30-OHK NHrsZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDnWmJKSzVyPUCuNVU3PzJizszN MX;TRW5ITVJ?
NCI-H716 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v6b2lEPTB;MD6xOlI3PiEQvF2= M4G0ZnNCVkeHUh?=
MPP-89 NH7lZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPCVGZKSzVyPUCuNVY6OzNizszN MXvTRW5ITVJ?
SF126 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvTbId[UUN3ME2wMlE4ODZ|IN88US=> M4TWZ3NCVkeHUh?=
CTB-1 NEi5dVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMUezNVYh|ryP M4rKPXNCVkeHUh?=
CA46 M3PoR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;wW3ZRUUN3ME2wMlE4PDh7IN88US=> MkLGV2FPT0WU
NCI-H520 NHHO[YlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHXSnlKSzVyPUCuNVc4OzJizszN M2PaW3NCVkeHUh?=
CAL-85-1 NXLxWGdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMUe5Nlch|ryP NHPRUGlUSU6JRWK=
NCI-H2342 M3u5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMUi1O|ch|ryP MX3TRW5ITVJ?
697 M3H5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUi4O|Eh|ryP NFe5NlJUSU6JRWK=
NY Ml3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\sTWM2OD1yLkG5Nlg4KM7:TR?= M2e4NHNCVkeHUh?=
T98G Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPzWmxKSzVyPUCuNVk{OThizszN M1m3WHNCVkeHUh?=
NCI-H1703 Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3JTWM2OD1yLkG5OlE2KM7:TR?= M{L3U3NCVkeHUh?=
NCI-H2087 NFnvZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7HVGNKSzVyPUCuNlA1OzlizszN NWfyU5hCW0GQR1XS
PF-382 MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jD[2lEPTB;MD6yNFg4OyEQvF2= M3nTNnNCVkeHUh?=
HCT-116 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;4e2lEPTB;MD6yNVA3QSEQvF2= MXTTRW5ITVJ?
CAKI-1 NWrzT|loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH4bnBKSzVyPUCuNlE3PjZizszN MW\TRW5ITVJ?
CCF-STTG1 NEjybFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMkK0O|Uh|ryP NITQW3VUSU6JRWK=
D-392MG NH\pbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMkOxO|ch|ryP MlnFV2FPT0WU
RT-112 NWXoV4Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Ky[2lEPTB;MD6yN|c6PSEQvF2= NF;S[FdUSU6JRWK=
MES-SA MnTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;SWGlEPTB;MD6yOFE5PyEQvF2= NWnIbllGW0GQR1XS
LC-2-ad NHzHeVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;yTWM2OD1yLkK0NlY2KM7:TR?= MW\TRW5ITVJ?
NOS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMkSzOlch|ryP NHTUN5RUSU6JRWK=
NALM-6 NH3ZZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMkW1OFMh|ryP NEPOeHNUSU6JRWK=
TE-15 NX3B[2hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm1eYhHUUN3ME2wMlI3ODlzIN88US=> MYPTRW5ITVJ?
786-0 M{jVVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMk[yNlgh|ryP NI\aXnVUSU6JRWK=
IST-MES1 M2XCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnUdY9KSzVyPUCuNlY5OjlizszN MUnTRW5ITVJ?
KYSE-180 NVzCfVdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHnNppKSzVyPUCuNlY5QTFizszN NX3MUG9SW0GQR1XS
YT MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvmTWM2OD1yLkK2PVc1KM7:TR?= MXvTRW5ITVJ?
A427 NVniVVVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVThN3A3UUN3ME2wMlI4OjZ2IN88US=> MUfTRW5ITVJ?
KYSE-450 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\GbGtCUUN3ME2wMlI4OzJ7IN88US=> MlfBV2FPT0WU
HuH-7 M4nqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\ST2RKSzVyPUCuNlc4PjNizszN MUXTRW5ITVJ?
CAS-1 MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fjXGlEPTB;MD6yPFMxOyEQvF2= MULTRW5ITVJ?
KURAMOCHI MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX6TWM2OD1yLkK4OFE6KM7:TR?= M3\BdHNCVkeHUh?=
ACHN NV;5U21zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrLbFdKSzVyPUCuNlk{OjNizszN Ml7vV2FPT0WU
HGC-27 NIWxcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[yV2lEPTB;MD6yPVM2OyEQvF2= MVjTRW5ITVJ?
A172 MkLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G1[2lEPTB;MD6yPVU4PyEQvF2= NH\4eGdUSU6JRWK=
SNU-449 NVfCOlRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorzTWM2OD1yLkK5PVY1KM7:TR?= M4TTfHNCVkeHUh?=
SW982 NI\6cnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWraR5p{UUN3ME2wMlI6QTd6IN88US=> MlPTV2FPT0WU
EFO-21 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3sWldKSzVyPUCuN|A1OTFizszN MWPTRW5ITVJ?
NCI-H2030 M3[3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDpTWM2OD1yLkOxNVY1KM7:TR?= MmnlV2FPT0WU
HT-144 Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjkTWM2OD1yLkOxNlgh|ryP M1j3VnNCVkeHUh?=
MFE-280 NVj5NmhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwM{G0OVMh|ryP NITvV4pUSU6JRWK=
SK-LU-1 M1HRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PpZmlEPTB;MD6zNVQ3PiEQvF2= NHjEeIlUSU6JRWK=
NCI-H2052 NXmzd2N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHWTWM2OD1yLkOxOFg1KM7:TR?= MVLTRW5ITVJ?
SK-HEP-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTRTWM2OD1yLkOzN|Y5KM7:TR?= MUPTRW5ITVJ?
QIMR-WIL NVSxWo5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH2TWM2OD1yLkOzOFI1KM7:TR?= NEHie5NUSU6JRWK=
A2780 NX\xOoFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXwd3lYUUN3ME2wMlM1OzB2IN88US=> NFf3W5BUSU6JRWK=
ACN NGLjWYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfNWFhCUUN3ME2wMlM1QDd|IN88US=> M4P6XnNCVkeHUh?=
BxPC-3 NYXWRld2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\YU2lEPTB;MD6zOFk5QSEQvF2= MWPTRW5ITVJ?
BCPAP NVHTcG5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjVUZdKSzVyPUCuN|YxODFizszN NFThR4hUSU6JRWK=
HOP-62 NVjidIduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrlZZZKSzVyPUCuN|YyODZizszN MVrTRW5ITVJ?
SW1710 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3sb2lyUUN3ME2wMlM3PDV3IN88US=> MnzUV2FPT0WU
OPM-2 NYnWOWgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[3TWM2OD1yLkO2OFc{KM7:TR?= M1q2SHNCVkeHUh?=
DBTRG-05MG NXf6W2x6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL2OGRYUUN3ME2wMlM5ODV2IN88US=> M2j6Z3NCVkeHUh?=
SK-MEL-24 NYXNeZR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LlUmlEPTB;MD6zPVc6OSEQvF2= M4jpb3NCVkeHUh?=
8305C NWLOeYI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4GzW2lEPTB;MD6zPVc6OyEQvF2= MYfTRW5ITVJ?
OVCAR-4 NVOwelVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S2RWlEPTB;MD60NVU5PiEQvF2= Ml7SV2FPT0WU
HLE MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\GcFdKSzVyPUCuOFE5PiEQvF2= M3;a[3NCVkeHUh?=
NCI-H747 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPqVI1JUUN3ME2wMlQzOTN5IN88US=> NXL4ZXY5W0GQR1XS
SW780 NUOyT5JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXUZlhoUUN3ME2wMlQzOzR4IN88US=> NInRPZFUSU6JRWK=
KYSE-150 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDSXndKSzVyPUCuOFI1OTVizszN MV;TRW5ITVJ?
H4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT4W3Z4UUN3ME2wMlQzPDVzIN88US=> M2PpcXNCVkeHUh?=
SW1088 Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjNWlJKSzVyPUCuOFQ{QSEQvF2= MnGxV2FPT0WU
SF268 MnrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULkR2ZmUUN3ME2wMlQ1QDZizszN NWDVW3JKW0GQR1XS
RT4 NV[wWlFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXuTWM2OD1yLkS1NVEyKM7:TR?= M4LibHNCVkeHUh?=
NCI-H522 M{\lXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PmV2lEPTB;MD60OVI4KM7:TR?= MlmyV2FPT0WU
LCLC-97TM1 NYTHc2NpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwNE[xPVUh|ryP M{HObHNCVkeHUh?=
CAL-39 NGTWeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M173UGlEPTB;MD60OlUyQSEQvF2= MlvmV2FPT0WU
CAL-120 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDNdIxKSzVyPUCuOFc3PDNizszN NYTDSJZ1W0GQR1XS
ESS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLGTWM2OD1yLkS3PFIyKM7:TR?= MnXDV2FPT0WU
KARPAS-45 MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNEi5N|Mh|ryP M3\iSXNCVkeHUh?=
DU-4475 M{i5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zqfWlEPTB;MD60PVUyOSEQvF2= MkToV2FPT0WU
VMRC-RCZ MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLKZnVyUUN3ME2wMlQ6QTB2IN88US=> NVHjc4xDW0GQR1XS
HOS NVn5XYRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPUdVNIUUN3ME2wMlUxOzZ3IN88US=> M4rXNnNCVkeHUh?=
MOLT-16 NHLDN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwNUG4NFgh|ryP MXXTRW5ITVJ?
RPMI-6666 M1fhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUSzVVI2UUN3ME2wMlUzOTN3IN88US=> NIO4UYNUSU6JRWK=
K052 NEi0SHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHo[W57UUN3ME2wMlUzOTRizszN NX;vbo5WW0GQR1XS
EHEB MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwNUKxPFIh|ryP NInue3BUSU6JRWK=
MFH-ino NEnlZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\pbI1UUUN3ME2wMlUzOzVzIN88US=> MVXTRW5ITVJ?
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SNG-M NWmxNWdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LmcmlEPTB;MT65OVg2QCEQvF2= NH\lUJZUSU6JRWK=
A673 Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TBWmlEPTB;MT65O|UyPiEQvF2= MmfqV2FPT0WU
L-428 MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XpfWlEPTB;MT65PVE4QSEQvF2= NEXSfVhUSU6JRWK=
KM-H2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\OeW9KSzVyPUKuNFExQSEQvF2= NIntcXZUSU6JRWK=
MC-IXC M2f6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTEToQ5UUN3ME2yMlAzOjd|IN88US=> M2ixb3NCVkeHUh?=
COLO-678 NWruSoRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwMESyNFch|ryP NES3[IdUSU6JRWK=
MEL-JUSO MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3njWmlEPTB;Mj6wO|g2OSEQvF2= NWHM[ItJW0GQR1XS
HCC38 M3q5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJwMEi0N|Mh|ryP NH\YUYFUSU6JRWK=
UACC-62 NUHSZldiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ztOWlEPTB;Mj6wPFg2PSEQvF2= NHjoNZBUSU6JRWK=
OAW-42 M1TpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJwMEm3NVEh|ryP MVzTRW5ITVJ?
LB996-RCC M17TXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJwMUO4NVch|ryP MUXTRW5ITVJ?
COR-L105 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{WyVWlEPTB;Mj6xOlM4OyEQvF2= MoCyV2FPT0WU
RCC10RGB NGnyXlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOzZXpKSzVyPUKuNVg2PzZizszN NE\5XHpUSU6JRWK=
A431 NHvZV2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn1UHhKSzVyPUKuNVkxOTlizszN NFuzW5ZUSU6JRWK=
NCI-H292 NUDwVlcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJwMkO5OVEh|ryP NF;tVWpUSU6JRWK=
SK-UT-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PPVGlEPTB;Mj6zN|E5PCEQvF2= NFmwWnlUSU6JRWK=
PANC-08-13 NXPYUmI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfQR3VKSzVyPUKuN|MzOzVizszN MV;TRW5ITVJ?
ST486 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW5TWM2OD1{LkSxNFQ5KM7:TR?= Mo\FV2FPT0WU
SJSA-1 NW\1b|hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX5[YlWUUN3ME2yMlQyOjdzIN88US=> NIL1O3JUSU6JRWK=
RKO NF:yUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n2OWlEPTB;Mj60NlAzQSEQvF2= MnnQV2FPT0WU
NCI-H1793 M1vhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nveWlEPTB;Mj60OFAzQSEQvF2= M2DWNHNCVkeHUh?=
639-V MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPzTWM2OD1{LkS1N|gzKM7:TR?= MWrTRW5ITVJ?
ES3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjI[mlKSzVyPUKuOFk4OzdizszN MkLvV2FPT0WU
NCI-H1792 NGDOdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDKPFNDUUN3ME2yMlU3QDJ4IN88US=> NFH4ZpdUSU6JRWK=
NCI-H1651 MmDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HiRmlEPTB;Mj61PFIyKM7:TR?= MV7TRW5ITVJ?
SN12C NHfNNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3u[4x[UUN3ME2yMlU5PDh5IN88US=> Mo\RV2FPT0WU
COLO-679 MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\XZYZKSzVyPUKuOVg3ODVizszN Mn3VV2FPT0WU
U-118-MG MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJwNUi4O|Ih|ryP MYXTRW5ITVJ?
Ramos-2G6-4C10 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPRTWM2OD1{Lk[0PFA4KM7:TR?= MoPFV2FPT0WU
HCT-15 NED6T4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jXUGlEPTB;Mj62PFc6OiEQvF2= NIfFTlhUSU6JRWK=
MDA-MB-157 NID1b4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXFVFdKSzVyPUKuO|A4PDdizszN M1PSOXNCVkeHUh?=
K5 NVOwN4hnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvycJJKSzVyPUKuO|E5PDVizszN NWH1cGlrW0GQR1XS
MKN45 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD0N2E1UUN3ME2yMlc{OzZ4IN88US=> NXnidHhOW0GQR1XS
DMS-273 NXnrPFhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\4[VBEUUN3ME2yMlc2PjN{IN88US=> M1\MVHNCVkeHUh?=
C8166 NXPNS4ozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwN{i1NVMh|ryP NXnINo5ZW0GQR1XS
Calu-3 M4TyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJwN{i5Olkh|ryP MXvTRW5ITVJ?
SNB75 NFOwRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HO[GlEPTB;Mj64PFU{PSEQvF2= NXe4SVdDW0GQR1XS
BFTC-905 Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rrcWlEPTB;Mj65NFE6OSEQvF2= MUXTRW5ITVJ?
C-4-II M4foUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe5XZBjUUN3ME2yMlkyOzV|IN88US=> NFH0T2hUSU6JRWK=
MS-1 NF3ZUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3qTWM2OD1{Lkm2O|Y6KM7:TR?= M1;FeXNCVkeHUh?=
A375 NWLGcIpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNwMEixPFQh|ryP MknrV2FPT0WU
KYSE-70 NGnFblNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzXNnRmUUN3ME2zMlA5QDh{IN88US=> NFXtTG9USU6JRWK=
KYSE-510 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vjW2lEPTB;Mz6xNFk6PSEQvF2= M3SwWHNCVkeHUh?=
LN-405 NX7ZT5hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HU[WlEPTB;Mz6xN|UyQCEQvF2= NEHtZVZUSU6JRWK=
BOKU M3LKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPidWFkUUN3ME2zMlE1OjV4IN88US=> M3LvRnNCVkeHUh?=
TE-10 NWDCT4R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNwMUezOlIh|ryP NX:5NXVFW0GQR1XS
MKN1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPvTWM2OD1|LkG4OFg{KM7:TR?= Mk\0V2FPT0WU
M059J M4DleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX0TWM2OD1|LkKwNVc{KM7:TR?= M37WdXNCVkeHUh?=
GOTO NGfWTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjoZ2dFUUN3ME2zMlIzODN7IN88US=> M2K4dnNCVkeHUh?=
DK-MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTkTWM2OD1|LkK1PVc3KM7:TR?= MX7TRW5ITVJ?
NCI-H727 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TqUWlEPTB;Mz6yOlU5KM7:TR?= MVrTRW5ITVJ?
NB12 MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\ITWM2OD1|LkOzNlI1KM7:TR?= M{f2TnNCVkeHUh?=
DOK NX3HXG5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTNwM{[xPFYh|ryP MXrTRW5ITVJ?
KYSE-410 NHThNoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jYR2lEPTB;Mz6zOlI5PyEQvF2= MlHTV2FPT0WU
AM-38 NWrTOHo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPLe2hKSzVyPUOuN|gxPTFizszN M2LUN3NCVkeHUh?=
GR-ST M37FWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHCWYlKSzVyPUOuOFU4OzJizszN MUDTRW5ITVJ?
D-247MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLNd3RKSzVyPUOuOFgzPjNizszN M{G4bXNCVkeHUh?=
TE-8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfyfYREUUN3ME2zMlQ6OzN|IN88US=> NGjVRmtUSU6JRWK=
LS-411N M{\5UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nEdmlEPTB;Mz60PVY6OiEQvF2= MXXTRW5ITVJ?
SK-MES-1 M1fIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETKdJlKSzVyPUOuOVY1OzNizszN NFqxcmJUSU6JRWK=
SF295 NF7wR|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\6c4tqUUN3ME2zMlYyPTV{IN88US=> NHXsdIJUSU6JRWK=
SK-MEL-30 M3[zNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TDTGlEPTB;Mz62OVkzOSEQvF2= M{XuRXNCVkeHUh?=
LB2241-RCC NIW0UlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTNwNk[yOkDPxE1? M3jpdnNCVkeHUh?=
PC-14 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXzTWM2OD1|Lk[2OFM4KM7:TR?= NIXETm5USU6JRWK=
EW-7 NYnITIt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwNke2PVMh|ryP MX\TRW5ITVJ?
NMC-G1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\IeFlRUUN3ME2zMlcyQDN5IN88US=> NGXtbpFUSU6JRWK=
TE-441-T MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTNwN{OwNlgh|ryP M2rVSnNCVkeHUh?=
NCI-H1618 NGfjOVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq4bVJzUUN3ME2zMlgyQDd3IN88US=> M4S4VnNCVkeHUh?=
PANC-03-27 NVfVXo9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvLN2FKSzVyPUOuPFE6OTZizszN M4mxNHNCVkeHUh?=
NCI-H2228 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHzfGpKSzVyPUOuPFMyOjZizszN NFixfI5USU6JRWK=
CAPAN-1 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLISJlJUUN3ME2zMlg4ODB7IN88US=> Mlm5V2FPT0WU
KLE NUD2SFBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfNWWtHUUN3ME2zMlkxPjdizszN MoDwV2FPT0WU
Becker NWPxbnp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHOVY1KSzVyPUOuPVI5PDlizszN NEfTcphUSU6JRWK=
SK-PN-DW NEntVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGi1fZRKSzVyPUSuNFc6PzRizszN MnHPV2FPT0WU
Hs-578-T MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PCcWlEPTB;ND6wPFMxPiEQvF2= NI\4eFhUSU6JRWK=
RS4-11 MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX1TXRKSzVyPUSuNVEzPTVizszN MVTTRW5ITVJ?
D-502MG NX\CRWJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{frT2lEPTB;ND6xOlk6PyEQvF2= NF\kVXpUSU6JRWK=
GI-1 NWDyNG5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T0Z2lEPTB;ND6yPFI6QSEQvF2= NVzRNpE1W0GQR1XS
NCI-H209 NIraVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr4R|g4UUN3ME20MlM{PzhizszN MlPCV2FPT0WU
SK-OV-3 M4rlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTRwNEixOFkh|ryP MmDFV2FPT0WU
LOUCY MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTRwNEi0N|Ih|ryP MV;TRW5ITVJ?
NCI-H69 NYHsfplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLNRVNKSzVyPUSuOVE4QTNizszN M2jvW3NCVkeHUh?=
SCC-9 MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK5SHAzUUN3ME20MlU{OTd{IN88US=> MXnTRW5ITVJ?
NCI-H526 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojoTWM2OD12LkW5Nlk{KM7:TR?= NXnESIQ1W0GQR1XS
NCI-H2170 NXX6R4VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHLUYhVUUN3ME20MlY3PzdzIN88US=> NHrI[oRUSU6JRWK=
SR M1XKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv4PId1UUN3ME20MlcxODR6IN88US=> NH;yPHpUSU6JRWK=
CMK NHPPN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XLXWlEPTB;ND63NlExOSEQvF2= MoK5V2FPT0WU
COLO-829 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfLV45TUUN3ME20Mlc4ODR|IN88US=> MmS3V2FPT0WU
HuO-3N1 NWfZU283T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\JboRKSzVyPUSuPFMzQDFizszN MV3TRW5ITVJ?
5637 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPM[3RRUUN3ME20MlkxPDh5IN88US=> NV;vZ4t6W0GQR1XS
A253 NICyOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q1d2lEPTB;ND65O|cxQCEQvF2= M2Wzd3NCVkeHUh?=
NB10 Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTVwMEe0PVch|ryP MWfTRW5ITVJ?
SF539 NEiwTmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGzZYc5UUN3ME21MlA6QTV7IN88US=> NWrwdWNqW0GQR1XS
HAL-01 NYnYZplIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2naXGlEPTB;NT6xOFY1PSEQvF2= M2LvXHNCVkeHUh?=
MHH-ES-1 NXroWolwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XZR2lEPTB;NT6xOlkzPSEQvF2= Mn7HV2FPT0WU
DEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7uWodKSzVyPUWuNlc2QDJizszN M1;XPXNCVkeHUh?=
NCI-H1299 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfITWM2OD13LkO1NFA4KM7:TR?= NFPmbZZUSU6JRWK=
ChaGo-K-1 NVz3WoE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr6TWM2OD13LkO1NVA4KM7:TR?= MVTTRW5ITVJ?
HMV-II M1LTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHrUpZEUUN3ME21MlM6PDNizszN NXryNnp6W0GQR1XS
NB69 NXnLUo5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnCSVZKSzVyPUWuN|k3OzFizszN MUnTRW5ITVJ?
NCI-H1882 NGPqd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv0ZohKSzVyPUWuOFM{PjRizszN MmHoV2FPT0WU
SNU-475 NGrxSYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwNEexO|Eh|ryP M2W5Z3NCVkeHUh?=
RXF393 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTVwNEi0PVQh|ryP NVyzTWh[W0GQR1XS
CAL-51 MorhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nOcWlEPTB;NT62Nlg2OyEQvF2= NXjVcXlFW0GQR1XS
SW1573 M4\iW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDI[osxUUN3ME21MlY{PTN2IN88US=> M1zRcXNCVkeHUh?=
GCT MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUntTJVIUUN3ME21Mlc2QTJ7IN88US=> Mn7EV2FPT0WU
COR-L88 NXro[WFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPpTWM2OD13Lke2PFQ3KM7:TR?= NHrLeJdUSU6JRWK=
MDA-MB-134-VI MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz2TWM2OD13Lki3OVM3KM7:TR?= Ml:yV2FPT0WU
NB5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PENWlEPTB;NT65NlQ1KM7:TR?= MXTTRW5ITVJ?
GMS-10 MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPJTWM2OD13Lkm2PFYyKM7:TR?= MVvTRW5ITVJ?
CHP-212 NFvsR5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK1TVRKSzVyPU[uOFgzPjdizszN NVvxNHdjW0GQR1XS
TE-11 NWXaXY0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfi[G5yUUN3ME22MlU2OTh{IN88US=> M3[xXHNCVkeHUh?=
SW962 M3XjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXy1eIhYUUN3ME22MlY2Pzd2IN88US=> MoHmV2FPT0WU
MZ2-MEL MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTZwOEKwNVEh|ryP MVrTRW5ITVJ?
C-33-A M3\ldGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTZwOUG2PFgh|ryP MXXTRW5ITVJ?
IGR-1 NHHTWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUToRVRJUUN3ME22Mlk4QDJ4IN88US=> NH;sflJUSU6JRWK=
MOLT-4 NHrZdYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTBenRLUUN3ME23MlE2PDB4IN88US=> MlzEV2FPT0WU
NCI-H1650 NXzJT4VbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuxSIlKSzVyPUeuNlcxPDZizszN M1jqSnNCVkeHUh?=
AsPC-1 NIq0SpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jLXGlEPTB;Nz6yPFYxPSEQvF2= NU\PeGY5W0GQR1XS
SNU-C2B NGjCUYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n3eGlEPTB;Nz6yPVU4OSEQvF2= M3PSVHNCVkeHUh?=
MKN7 NHHZRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nwbmlEPTB;Nz6zO|I{PSEQvF2= NU\4V2hiW0GQR1XS
SW620 NGDWdZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3XTWM2OD15LkO4NlA2KM7:TR?= MonnV2FPT0WU
SK-MEL-28 M3fZNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvsTWM2OD15LkSwO|k5KM7:TR?= MljOV2FPT0WU
TE-6 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTycFFZUUN3ME23MlQ1QTB6IN88US=> NWO1PGd{W0GQR1XS
D-263MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\0fWlEPTB;Nz60OVc3OiEQvF2= NGGxT4xUSU6JRWK=
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BB65-RCC MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fHTWlEPTB;MkOuNFM1PCEQvF2= M{PqWXNCVkeHUh?=
SiHa M3Ha[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nYWGlEPTB;MkOuN|k3QCEQvF2= M3q0WnNCVkeHUh?=
NCI-H2081 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJ2LkC2OFEh|ryP MVPTRW5ITVJ?
U251 MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTOXHQ1UUN3ME2yOE4xPjZ6IN88US=> MmX1V2FPT0WU
LoVo MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPOcW1vUUN3ME2yOE46Ojh{IN88US=> Ml;lV2FPT0WU
GCIY MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF30TpdKSzVyPUK1MlI5PzdizszN MW\TRW5ITVJ?
NUGC-3 NVfaWXF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJ3LkOzNVYh|ryP MXjTRW5ITVJ?
LNCaP-Clone-FGC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHLZmlJUUN3ME2yOU4{PDl6IN88US=> MkDpV2FPT0WU
PA-1 M{\QZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES0WYxKSzVyPUK1MlY5OzNizszN MkH6V2FPT0WU
OE33 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ3Lk[4OVMh|ryP MU\TRW5ITVJ?
HT-29 MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJ3Lke4O|kh|ryP NE\xeJNUSU6JRWK=
RCM-1 Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jiN2lEPTB;MkWuPVY2PiEQvF2= MmTDV2FPT0WU
NCI-H1522 M4G3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2GzU2lEPTB;MkWuPVkyOSEQvF2= MmDFV2FPT0WU
LB373-MEL-D MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF25bmRKSzVyPUK2MlE4ODhizszN NYfkVodoW0GQR1XS
NCI-H1436 M{nyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXkTWM2OD1{Nj6yO|M5KM7:TR?= NGnybXhUSU6JRWK=
COLO-824 NXTXbG1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjDeHQ6UUN3ME2yOk41ODB{IN88US=> MlW2V2FPT0WU
CP50-MEL-B MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnUTWM2OD1{Nj61Olc2KM7:TR?= MnrrV2FPT0WU
EGI-1 NFz4U3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPxSolKSzVyPUK3MlI3QThizszN NHjnUZhUSU6JRWK=
LAN-6 M1T4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJ5LkO1PVgh|ryP MnHPV2FPT0WU
GAK NIXvTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXHTXNKSzVyPUK3MlQzOjVizszN NGXTOlVUSU6JRWK=
MDA-MB-175-VII NFrVR3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDaUplKSzVyPUK3MlUxPTNizszN NW\vSpNpW0GQR1XS
JVM-2 NUW0Sm5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7oToQzUUN3ME2yO{43PjJ{IN88US=> Ml3LV2FPT0WU
UACC-257 Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJ5Lk[4O|gh|ryP M33WcHNCVkeHUh?=
SW1783 NVXocZE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDzOZpKSzVyPUK3Mlc4QDNizszN MUXTRW5ITVJ?
HT-3 NHm1S5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmntTWM2OD1{OD6yNVY3KM7:TR?= M33udHNCVkeHUh?=
RL M4TIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ6LkW5NVEh|ryP NITWcWFUSU6JRWK=
TK10 NETUN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSy[mJKSzVyPUK4MlY2OzVizszN Mn3vV2FPT0WU
HT55 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;2NIJqUUN3ME2yPU4xPTZ3IN88US=> NEDRVY1USU6JRWK=
BT-20 MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfofpZWUUN3ME2yPU4xPTh4IN88US=> NF7mXnBUSU6JRWK=
TGBC24TKB MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDLTWM2OD1{OT6xPFMyKM7:TR?= NEC0NWFUSU6JRWK=
HSC-2 M{Laemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX75R4NVUUN3ME2yPU4{ODBzIN88US=> Mlr4V2FPT0WU
COLO-205 NXn0VGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ7LkO5OFQh|ryP NXnGS5J1W0GQR1XS
GT3TKB M{jUPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fWPGlEPTB;MkmuOlg4PyEQvF2= NWfRcog2W0GQR1XS
T47D MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJ7Lki1PFIh|ryP MXjTRW5ITVJ?
OMC-1 M4exVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnkTWM2OD1|MD6xPVE6KM7:TR?= Mlr6V2FPT0WU
PFSK-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNzLkK2OVkh|ryP MXzTRW5ITVJ?
JEG-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnq[odKSzVyPUOxMlM2PjFizszN M{nRUXNCVkeHUh?=
RD M3L1PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfmZ2VKSzVyPUOxMlUyOTVizszN NV;5XplXW0GQR1XS
NCI-H64 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TOOmlEPTB;M{KuOFE4QSEQvF2= NEK4XlNUSU6JRWK=
DMS-114 NEHBNGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37wUGlEPTB;M{KuOFE5OiEQvF2= MkfLV2FPT0WU
NCI-H661 MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LqcmlEPTB;M{KuOlUxOSEQvF2= MmfCV2FPT0WU
CAL-148 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:zPXZiUUN3ME2zNk43PjZ3IN88US=> MmPQV2FPT0WU
HuP-T3 NVO4SXlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN{LkmzN|gh|ryP NEHQUG9USU6JRWK=
ES4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHUTWM2OD1|Mz6xO|A2KM7:TR?= NUexUZVlW0GQR1XS
Ca9-22 NITHdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn3O4tWUUN3ME2zN{41PjBzIN88US=> MX;TRW5ITVJ?
LP-1 M1PO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\WTWM2OD1|ND6wPUDPxE1? MWTTRW5ITVJ?
AU565 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHviUZdKSzVyPUO0MlUxPjlizszN Mkn3V2FPT0WU
MDA-MB-453 M4TRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN3LkG0NlYh|ryP NE\iVYZUSU6JRWK=
SNU-C1 NXPhRWlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\OTWM2OD1|NT6xO|Eh|ryP NFe4d|dUSU6JRWK=
SW13 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTJXXVbUUN3ME2zOU41ODd4IN88US=> NWC1RlQxW0GQR1XS
NCI-H2122 NXTINoVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXofWRKSzVyPUO1MlU2QThizszN NFnaWlJUSU6JRWK=
NCI-H1395 NVvpfZA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTN3Lk[2PVEh|ryP MXTTRW5ITVJ?
J-RT3-T3-5 NFXi[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7OTWM2OD1|Nj6wNlk1KM7:TR?= NFzqUZlUSU6JRWK=
COR-L279 M2npZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN4LkG5PFEh|ryP NXTRWZZrW0GQR1XS
ATN-1 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jsdmlEPTB;M{[uPFUyPiEQvF2= MmXTV2FPT0WU
HCC2998 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofuTWM2OD1|Nj64OVcyKM7:TR?= M4TWbnNCVkeHUh?=
UM-UC-3 MofES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\KbmlEPTB;M{[uPFY4PSEQvF2= M{nzbXNCVkeHUh?=
DV-90 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN4LkmwOlch|ryP M2rsUHNCVkeHUh?=
ES8 MkHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnqZ3FKSzVyPUO2Mlk{OThizszN MkfZV2FPT0WU
YAPC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7tTWM2OD1|Nj65OlU1KM7:TR?= NFqzeFZUSU6JRWK=
HCC1599 M3LEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfwTWM2OD1|Nz6xOlE5KM7:TR?= NGfUPWlUSU6JRWK=
UMC-11 NVHQeZZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLUTWM2OD1|Nz6yOVA{KM7:TR?= NGDDTpRUSU6JRWK=
THP-1 NWr6cotIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN5LkK4Olgh|ryP NXLxOHVbW0GQR1XS
OCUB-M M{i3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvLb5pKSzVyPUO3MlI5QTFizszN MVLTRW5ITVJ?
NCI-H1693 MlezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLQUI9KSzVyPUO3MlMzOzNizszN MnG1V2FPT0WU
NCI-H345 NHHjdG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn4TWM2OD1|Nz6zOlI1KM7:TR?= M3P5TXNCVkeHUh?=
COLO-800 NYnvRpQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHJTWM2OD1|Nz61Olch|ryP Mn;6V2FPT0WU
COLO-320-HSR MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrjO4ZKSzVyPUO4MlM1QTJizszN MmPCV2FPT0WU
NCI-H596 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDB[GVKSzVyPUO4MlQ1QDlizszN NEjSRYhUSU6JRWK=
NCI-H187 Ml7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP1TWM2OD1|OD63N|Q1KM7:TR?= NX2zUJpxW0GQR1XS
ECC4 NUW0NXg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN7LkC4NVQh|ryP M{D2VXNCVkeHUh?=
KP-4 NFjJem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LsdWlEPTB;M{muNVI{PSEQvF2= NU[3Xow3W0GQR1XS
NCI-H2227 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDEeZhKSzVyPUO5MlM6PDlizszN MWnTRW5ITVJ?
22RV1 NFv4SVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:xb|ZKSzVyPUO5Mlg{QThizszN MV3TRW5ITVJ?
SAS MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPSe3dbUUN3ME20NE4xQTZizszN NXvndYFQW0GQR1XS
PANC-10-05 MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUey[3FKUUN3ME20NE4yQDJ6IN88US=> NGH5TWZUSU6JRWK=
MDA-MB-468 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULHNHZ[UUN3ME20NE42OzR4IN88US=> MkH6V2FPT0WU
RPMI-7951 NX3yN4c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvuTWM2OD12MT6yNFc2KM7:TR?= NXK2fXkyW0GQR1XS
BB49-HNC M3rXTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Ww[GlEPTB;NEGuNlE4QSEQvF2= MojQV2FPT0WU
23132-87 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnmWYp5UUN3ME20NU4zPzN{IN88US=> M3LVWnNCVkeHUh?=
HCC1569 M1fEfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP1TWM2OD12MT6yPFg2KM7:TR?= NHrDRVhUSU6JRWK=
CP66-MEL Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TndmlEPTB;NEKuNVg5PiEQvF2= NHzXd2RUSU6JRWK=
K-562 M{\jdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G1VGlEPTB;NEKuNlg2PCEQvF2= NV3VZVZrW0GQR1XS
OCI-AML2 NGLYdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR{Lki5O|Qh|ryP NWjpZ2I{W0GQR1XS
SW756 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HTOWlEPTB;NEOuNFM5QCEQvF2= M1XhVXNCVkeHUh?=
M14 NHWzeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTR|LkOxPFkh|ryP NEDG[IlUSU6JRWK=
NCI-H1623 M2n5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlftTWM2OD12Mz60OlQh|ryP MkW4V2FPT0WU
KNS-81-FD MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjYRohKSzVyPUSzMlc3OiEQvF2= NG\TS|FUSU6JRWK=
TGBC1TKB MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjRUpBKSzVyPUSzMlkxQTlizszN NEC2OWJUSU6JRWK=
RERF-LC-MS NVTpcIJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj0eGVKSzVyPUSzMlkzQDFizszN NGHvR2lUSU6JRWK=
PC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR2LkSzOFch|ryP MYXTRW5ITVJ?
HuP-T4 M3nsd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR2LkS0O|Qh|ryP MVTTRW5ITVJ?
NCI-H510A M{\wZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR2LkewPEDPxE1? MWnTRW5ITVJ?
LB2518-MEL NEHYV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTR2Lke5N|ch|ryP NEXrW2dUSU6JRWK=
TE-5 NXLuPVRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXJTWM2OD12NT65OVgyKM7:TR?= MXjTRW5ITVJ?
EW-24 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTR4LkG3NlMh|ryP MoPqV2FPT0WU
LB647-SCLC NGS2PXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfuTJdKSzVyPUS2MlIyPTVizszN NG\wRndUSU6JRWK=
NCI-H524 NFXhfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTR4LkexPFUh|ryP NX62WoJLW0GQR1XS
EW-11 NW\IfW5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTR4LkmzO|Mh|ryP MXzTRW5ITVJ?
KALS-1 NVrx[FBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR5LkKwOlYh|ryP MYTTRW5ITVJ?
BT-474 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVj5To1VUUN3ME20O{41OjF4IN88US=> MUTTRW5ITVJ?
SK-N-AS MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPjTWM2OD12Nz64PFgh|ryP NHnifWlUSU6JRWK=
HCC2157 M2jMXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR6LkC3OkDPxE1? M3vifnNCVkeHUh?=
HCC1954 MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR6LkG3NFQh|ryP MlzjV2FPT0WU
FADU MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHKTWM2OD12OD6zNFMyKM7:TR?= MYXTRW5ITVJ?
S-117 NFz6W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTR6LkO4NVUh|ryP MVHTRW5ITVJ?
LS-1034 NV3pdmZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nSVGlEPTB;NEiuO|A3PyEQvF2= NF7iO2VUSU6JRWK=
CAMA-1 NYTtcFNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\mT5NKSzVyPUS5MlU2PDNizszN MWfTRW5ITVJ?
LU-134-A NXXFVW91T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjKbXRKSzVyPUS5MlgxQDVizszN NUHGVWRDW0GQR1XS
NCI-H1838 NWfle|NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H2dmlEPTB;NEmuPFA5PyEQvF2= NFHtemtUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
pSrc / Src / pPlcg / Plcg / pStat5 / Stat5 ; 

PubMed: 22781593     


In (B) inhibition of Src, Plcg and Stat5 was seen in MLNAF cell lines treated with Ponatinib; ZNF112 expresses ZMYM2–FGFR1, CEP2A and CEP5A cells express CEP110–FGFR1 and BBC2 expresses BCR–FGFR1.

pFGFR1(pY20) / FGFR1; 

PubMed: 22781593     


Western blot analysis, using various antibodies specific for downstream targets of FGFR1, demonstrates that Ponatinib inhibits the activation of Plcg and Src as a result of inhibiting the FGFR1 fusion kinase in human KG1 cells. 

cleaved caspase-3 / cleaved caspase-7 / BAX / Bcl-2; 

PubMed: 30959969     


Western blot analysis of cleaved caspase-3, cleaved caspase-7, Bax, Bcl-2, and β-Tubulin (control) in treated cells.

p-Rb(S807/811) / Rb / CDK4 / CDK6 / Cyclin D1 / CDK2 / Cyclin E1; 

PubMed: 30959969     


Western blot analysis of Rb/p-Rb, CDK4, CDK6, Cyclin D1, CDK2, Cyclin E1, and β-Tubulin (control) in the SK-Hep-1 and SNU-423 cells treated with ponatinib. 

RAD51; 

PubMed: 30959969     


The effect of ponatinib on the concentration of Rad51 in SK-Hep-1 and SNU-423 cells.

p-MEK / MEK / p-ERK / ERK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Mek and Erk. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

c-Jun / p-JNK(T183/Y185) / JNK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of JNK and c-Jun. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-p38 MAPK / p38 MAPK; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of p38. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

p-JAK2 / JAK2 / p-STAT3 / STAT3; 

PubMed: 30959969     


Effect of ponatinib on the phosphorylation of Jak2, and Stat3. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a control.

PI3K p85 / p-PI3K / p-PDK1 / PDK1 / p-mTOR / mTOR; 

PubMed: 30959969     


Effects of ponatinib on the protein concentration and phosphorylation of PI 3-kinase, PDK1, Akt, and mTOR in HCC cells. 

p-PDGFRα / PDGFRα; 

PubMed: 24472312     


Ponatinib inhibited phosphorylation of PDGFRα in a concentration-dependent manner. EOL-1 and BaF3-WT or -T674I FIP1L1-PDGFRα cells were exposed to escalating concentrations of ponatinib for 24 h.

PARP / Caspase-3 / Active Caspase-3; 

PubMed: 24472312     


The concentration- (for 24 h) and time-dependent (1 nM for EOL-1, 300 nM for BaF3-WT and -T674I FIP1L1-PDGFRα cells) cleavage of PARP and caspase-3 triggered by ponatinib was analyzed by immunoblotting.

AIF / Cyto C ; 

PubMed: 24472312     


Ponatinib elicited release of AIF and cytochrome c into the cytosol. Cells were treated with 1 nM ponatinib for the indicated durations and the cytosolic fraction was extracted with digitonin buffer. Levels of AIF and Cytochrome c (Cyto c) were detected by immunoblotting.

Mcl-1 / Survivin / Bcl-Xl / XIAP / Bax / Bcl-2 / Bim; 

PubMed: 24472312     


Immunoblotting of apoptosis-related proteins in CEL cells after treatment for 24 h.

β-catenin ; 

PubMed: 24472312     


Ponatinib concentration-dependently lowered β-catenin. EOL-1 cells were incubated with ponatinib for 24 h, and cytoplasmic and nuclear extracts were determined by immunoblotting.

β-catenin; 

PubMed: 24472312     


Analysis of β-catenin localization. EOL-1 cells were pretreated with 1 nM ponatinib for 24 h, immunofluorescence analysis was performed with anti-β-catenin. Nuclei were stained with 4,6-diamidino-2-phenylindole (DAPI). 

ABL; 

PubMed: 19878872     


In vitro [γ-32P]-ATP autophosphorylation of full-length (A) ABL or (B) ABLT315I kinase treated with AP24534, imatinib, nilotinib, or dasatinib. After incubation of tyrosine-dephosphorylated enzyme with the indicated inhibitor in the presence of [γ-32P]-ATP and separation by SDS-PAGE, signal intensity was measured by autoradiography.

22781593 30959969 24472312 19878872
Growth inhibition assay
Cell viability; 

PubMed: 30174789     


(A) Effect of Ponatinib on basal viability of HUVECs. The cells were treated with Ponatinib at indicated concentrations or 0.1% DMSO (vehicle control) for 24 h.

30174789
In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A
Smiles CN1CCN(CC1)CC2=C(C=C(NC(=O)C3=CC(=C(C)C=C3)C#CC4=CN=C5C=CC=N[N]45)C=C2)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04160546 Recruiting Drug: Ponatinib 15 MG|Drug: Acetylsalicylic acid 100 MG Chronic Myeloid Leukemia Chronic Phase Fundacion CRIS de Investigación para Vencer el Cáncer|Incyte Biosciences UK|Apices Soluciones S.L. January 17 2020 Phase 2
NCT04070443 Recruiting Drug: Ponatinib|Drug: Imatinib Philadelphia Chromosome Positive CML|BCR-ABL Positive Chronic Myelogenous Leukemia Centre Leon Berard November 13 2019 Phase 2
NCT03934372 Recruiting Drug: Ponatinib Acute Myeloid Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Blast Phase Chronic Myeloid Leukemia|Chronic Phase Chronic Myeloid Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukemia|Leukemia|Lymphoma|Solid Tumors Incyte Biosciences International Sàrl|Incyte Corporation November 22 2019 Phase 1|Phase 2
NCT03895671 Recruiting Drug: Ponatinib|Drug: Azacitidine CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE|CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS Versailles Hospital June 19 2019 Phase 2
NCT03690115 Recruiting Drug: Ponatinib 30 MG Leukemia Myeloid Acute Versailles Hospital December 12 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID