Ponatinib (AP24534)

Catalog No.S1490

Ponatinib (AP24534) Chemical Structure

Molecular Weight(MW): 532.56

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.

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Cited by 31 Publications

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  •  

    RCH-ACV cells were treated with ponatinib(50 nM), PCI-32765(50 nM), or BMS-599626(500 nM) over a time course, and whole-cell extracts were subjected to immunoblot analysis for total or phospho-AKT.
     

    Cancer Cell 2012 22(5), 656-667 . Ponatinib (AP24534) purchased from Selleck.

    Proliferation curves of established human (A), novel human (B), and murine(C) IDHm (red) and WT (black) ICC lines and MMNK-1 cells treated with increasing doses of the TKIs dasatinib, saracatinib, bosutinib, and ponatinib.

    Cancer Discov, 2016, 6(7):727-39.. Ponatinib (AP24534) purchased from Selleck.

  • The KatoIII diffuse gastric cancer cell line was treated with FGFR2 inhibitors of varying specificity. The Y-axis depicts percent survival versus the X-axis with log concentrations.

    Genome Biol, 2014, 15(8): 428 . Ponatinib (AP24534) purchased from Selleck.

    Western blot analysis of LC-2/ad cells treated with increasing doses of ponatinib for 2 hours. Lysates were analyzed via western blotting with the antibodies indicated, with P-TYR used to assess P-RET

    Mol Cancer Ther, 2017, 16(8):1623-1633. Ponatinib (AP24534) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
PDGFRα [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
c-Src [1]
(Cell-free assay)
0.37 nM 1.1 nM 1.5 nM 2.2 nM 5.4 nM
In vitro

AP24534 potently inhibits native Abl, AblT315I, and other clinically important Abl kinase domain mutants with IC50 of 0.30 nM–2 nM. AP24534 doesn't inhibit Aurora kinase family members, nor does it inhibit insulin receptor or CDK2/cyclin E. AP24534 inhibits proliferation of Ba/F3 cells expressing Bcr-Abl with IC50 of 0.5 nM, as well as Ba/F3 cells expressing a range of Bcr-Abl mutants with IC50 of 0.5 nM–36 nM. The inhibition of proliferation by AP24534 is correlated with induction of apoptosis. [1-2] In leukemic cell lines containing activated forms of FLT3, KIT, FGFR1, and PDGFRα receptors, AP24534 potently inhibits receptor phosphorylation and cellular proliferation with IC50 of 0.3 nM to 20 nM. In MV4-11 (FLT3-ITD(+/+)) but not RS4;11 (FLT3-ITD(–/–)) AML cells, AP24534 inhibits FLT3 signaling and induced apoptosis at less than 10 nM. AP24534 inhibits viability of primary leukemic blasts from a FLT3-ITD positive AML patient with IC50 of 4 nM but not those from patients with AML expressing native FLT3. [3] In Ba/F3 cells engineered to express activated FGFR1-4, AP24534 potently inhibits FGFR-mediated signaling and viability with IC50 lower than 40 nM. In cell lines representing multiple tumor types (endometrial, bladder, gastric, breast, lung, and colon), and containing FGFRs dysregulated by a variety of mechanisms, AP24534 inhibits FGFR-mediated signaling with IC50 less than 40 nM and inhibits cell growth with IC50 of 7 nM–181 nM. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EoL-1-cell NWr6N2U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\FdYF5UUN3ME2wMlAxODByMECzOVkh|ryP NXf5Rmg2W0GQR1XS
MV-4-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnzOHBKSzVyPUCuNFAxODl3NjFOwG0> Ml\HV2FPT0WU
MEG-01 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\2V2lEPTB;MD6wNFAyOjhizszN NXjpO3VNW0GQR1XS
LAMA-84 NWfENZNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMECwNVY2KM7:TR?= MUnTRW5ITVJ?
CGTH-W-1 NXfCcoNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7vTWM2OD1yLkCwNVY6KM7:TR?= MlPDV2FPT0WU
KASUMI-1 M1TRR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HyRmlEPTB;MD6wNFIyPyEQvF2= NVfEV2VwW0GQR1XS
BE-13 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\RTWM2OD1yLkCwNlU6KM7:TR?= MlP5V2FPT0WU
CTV-1 NF7PSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPXTWM2OD1yLkCwOVIyKM7:TR?= NYTMV|l[W0GQR1XS
NKM-1 M2XOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPOOpVKSzVyPUCuNFA3PTVizszN MkXrV2FPT0WU
MONO-MAC-6 M3jaZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\DfGlEPTB;MD6wNFg{PyEQvF2= M2LLbXNCVkeHUh?=
A204 MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEGyNVgh|ryP NGDpZnBUSU6JRWK=
GDM-1 M3\aUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\XfXZiUUN3ME2wMlAyQDN|IN88US=> MWPTRW5ITVJ?
AN3-CA M{TZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEG4O|Mh|ryP MVnTRW5ITVJ?
BL-70 NEjhR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnnSXpyUUN3ME2wMlAzOTl7IN88US=> MYXTRW5ITVJ?
Daudi MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEK1N|ch|ryP M3TsVHNCVkeHUh?=
KU812 MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMEK4OFgh|ryP NW\qV2FvW0GQR1XS
KG-1 NEPnNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1OxNmlEPTB;MD6wN|I6PCEQvF2= M1SzUnNCVkeHUh?=
DOHH-2 NXfRdHc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrtTWM2OD1yLkC0PFA{KM7:TR?= M{\tPHNCVkeHUh?=
HuO9 M2j2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEW0OFgh|ryP NV\hfHFuW0GQR1XS
EB2 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7KNolQUUN3ME2wMlA2PTd4IN88US=> MWrTRW5ITVJ?
G-402 NVLZc45XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHaRnlKSzVyPUCuNFY{PDFizszN NHOySWdUSU6JRWK=
SU-DHL-1 NIO4e4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTjNIJtUUN3ME2wMlA3Ozd7IN88US=> MX;TRW5ITVJ?
NCI-H719 M3rTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYixNlQyUUN3ME2wMlA4QDh6IN88US=> MXfTRW5ITVJ?
MLMA MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXKbGJDUUN3ME2wMlA6ODZizszN MXLTRW5ITVJ?
KM12 NGTJUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LzZWlEPTB;MD6wPVc{PyEQvF2= NGTMfHlUSU6JRWK=
SUP-T1 NV;DenB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDVd3VjUUN3ME2wMlA6QTh{IN88US=> NGjWWmFUSU6JRWK=
MZ1-PC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q4NGlEPTB;MD6xNVM{PiEQvF2= M{\IW3NCVkeHUh?=
MFE-296 MlzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnHUop5UUN3ME2wMlEyQDN7IN88US=> NHrRT41USU6JRWK=
ALL-PO MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7wdJpKSzVyPUCuNVI1PDNizszN NVzkfmRjW0GQR1XS
GB-1 NF2xcmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXBTWM2OD1yLkGyOVEzKM7:TR?= MYjTRW5ITVJ?
SIG-M5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjVd5dXUUN3ME2wMlE{OzdizszN MXnTRW5ITVJ?
P30-OHK MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;rdWlEPTB;MD6xOVY4OiEQvF2= NGHjUnBUSU6JRWK=
NCI-H716 M4KzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;V[WVDUUN3ME2wMlE3OjZ4IN88US=> NETKc5pUSU6JRWK=
MPP-89 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\FTJNKSzVyPUCuNVY6OzNizszN M3PXNHNCVkeHUh?=
SF126 M3nv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMUewOlMh|ryP NWm3WIIzW0GQR1XS
CTB-1 NEDLfoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr5TnpXUUN3ME2wMlE4OzF4IN88US=> M1naVHNCVkeHUh?=
CA46 NUnkN21pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;5[WlEPTB;MD6xO|Q5QSEQvF2= M4PVenNCVkeHUh?=
NCI-H520 NEXhbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMUe3N|Ih|ryP M1LxW3NCVkeHUh?=
CAL-85-1 NWXUOlA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1yLkG3PVI4KM7:TR?= MYXTRW5ITVJ?
NCI-H2342 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfiOmNKSzVyPUCuNVg2PzdizszN Mny2V2FPT0WU
697 NV7xd|ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LydWlEPTB;MD6xPFg4OSEQvF2= MonCV2FPT0WU
NY MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[xTWM2OD1yLkG5Nlg4KM7:TR?= Mn3tV2FPT0WU
T98G NHXu[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\QTWM2OD1yLkG5N|E5KM7:TR?= M4O4eXNCVkeHUh?=
NCI-H1703 NYThe2c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMUm2NVUh|ryP NXX1V4dKW0GQR1XS
NCI-H2087 NYDt[mJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLSUHJKSzVyPUCuNlA1OzlizszN M{fzNnNCVkeHUh?=
PF-382 NV7vNFBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHZb2hKSzVyPUCuNlA5PzNizszN MVnTRW5ITVJ?
HCT-116 M1LO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjFcYxsUUN3ME2wMlIyODZ7IN88US=> M2LjOHNCVkeHUh?=
CAKI-1 NYP1SoF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMkG2OlYh|ryP NWq1OmNPW0GQR1XS
CCF-STTG1 NFrLOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLqTWM2OD1yLkKyOFc2KM7:TR?= NYHBR3dKW0GQR1XS
D-392MG NIr2[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMkOxO|ch|ryP NGn4U3hUSU6JRWK=
RT-112 NHqyephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfLSGhKUUN3ME2wMlI{Pzl3IN88US=> M1WzUHNCVkeHUh?=
MES-SA NFfvN49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorkTWM2OD1yLkK0NVg4KM7:TR?= NYrWcnc{W0GQR1XS
LC-2-ad MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknmTWM2OD1yLkK0NlY2KM7:TR?= M3rOV3NCVkeHUh?=
NOS-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDqZlFKSzVyPUCuNlQ{PjdizszN MWHTRW5ITVJ?
NALM-6 M37hOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHXemhrUUN3ME2wMlI2PTR|IN88US=> NVfLb5V2W0GQR1XS
TE-15 MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe5PWdRUUN3ME2wMlI3ODlzIN88US=> M3f5OnNCVkeHUh?=
786-0 NXrPNmFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMk[yNlgh|ryP M2TNU3NCVkeHUh?=
IST-MES1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljTTWM2OD1yLkK2PFI6KM7:TR?= M4HZV3NCVkeHUh?=
KYSE-180 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHywVpVKSzVyPUCuNlY5QTFizszN NYrnNZNEW0GQR1XS
YT NYPUcY5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f3PGlEPTB;MD6yOlk4PCEQvF2= M1LwNXNCVkeHUh?=
A427 NWfxUlhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DwSmlEPTB;MD6yO|I3PCEQvF2= NX\FfWpCW0GQR1XS
KYSE-450 NHWzTIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMkezNlkh|ryP NXfrUolOW0GQR1XS
HuH-7 NIPneWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2zT41VUUN3ME2wMlI4PzZ|IN88US=> NV3HT4NzW0GQR1XS
CAS-1 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHkN4lKSzVyPUCuNlg{ODNizszN NYPLZYxrW0GQR1XS
KURAMOCHI M{XhbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPoRo5KSzVyPUCuNlg1OTlizszN MYXTRW5ITVJ?
ACHN MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjwVIhKSzVyPUCuNlk{OjNizszN MnLUV2FPT0WU
HGC-27 NVnIRnl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi1[HRKSzVyPUCuNlk{PTNizszN NHz4PYRUSU6JRWK=
A172 MnP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPQb|FKSzVyPUCuNlk2PzdizszN MmLlV2FPT0WU
SNU-449 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrlNnZKSzVyPUCuNlk6PjRizszN NULmbmU2W0GQR1XS
SW982 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMkm5O|gh|ryP MX\TRW5ITVJ?
EFO-21 MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwM{C0NVEh|ryP MYrTRW5ITVJ?
NCI-H2030 NHixZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4ja[WlEPTB;MD6zNVE3PCEQvF2= NVfwS4I{W0GQR1XS
HT-144 NGTnUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwM{GyPEDPxE1? MW\TRW5ITVJ?
MFE-280 NHT2fGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jsc2lEPTB;MD6zNVQ2OyEQvF2= MU\TRW5ITVJ?
SK-LU-1 M4K0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkftTWM2OD1yLkOxOFY3KM7:TR?= Mo\2V2FPT0WU
NCI-H2052 NFWycIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm5UGE3UUN3ME2wMlMyPDh2IN88US=> NVf5d3J1W0GQR1XS
SK-HEP-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwM{OzOlgh|ryP MVvTRW5ITVJ?
QIMR-WIL MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwM{O0NlQh|ryP MV;TRW5ITVJ?
A2780 NI\ZXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwM{SzNFQh|ryP NIr0TnZUSU6JRWK=
ACN NV75d4w3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32ydWlEPTB;MD6zOFg4OyEQvF2= Mm[xV2FPT0WU
BxPC-3 M{LYOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG3WoM3UUN3ME2wMlM1QTh7IN88US=> M4fG[3NCVkeHUh?=
BCPAP M{\tdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfyU|dKSzVyPUCuN|YxODFizszN NYnQ[5N4W0GQR1XS
HOP-62 NWT4PVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPRTWM2OD1yLkO2NVA3KM7:TR?= MoL4V2FPT0WU
SW1710 NUXLZ4ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnxSoFKSzVyPUCuN|Y1PTVizszN MYnTRW5ITVJ?
OPM-2 NWnrZ3JPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLSeINKSzVyPUCuN|Y1PzNizszN M4DYPXNCVkeHUh?=
DBTRG-05MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOwcGVLUUN3ME2wMlM5ODV2IN88US=> NUjRU2UxW0GQR1XS
SK-MEL-24 M1rF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq0TWM2OD1yLkO5O|kyKM7:TR?= M13FVHNCVkeHUh?=
8305C MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LGS2lEPTB;MD6zPVc6OyEQvF2= M2LscHNCVkeHUh?=
OVCAR-4 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fKemlEPTB;MD60NVU5PiEQvF2= NFrwNoZUSU6JRWK=
HLE NFTRUo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rLZWlEPTB;MD60NVg3KM7:TR?= MXHTRW5ITVJ?
NCI-H747 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LlN2lEPTB;MD60NlE{PyEQvF2= M3r5S3NCVkeHUh?=
SW780 NVTZbZR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrr[25KSzVyPUCuOFI{PDZizszN MXLTRW5ITVJ?
KYSE-150 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DETmlEPTB;MD60NlQyPSEQvF2= MkT3V2FPT0WU
H4 Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T0RWlEPTB;MD60NlQ2OSEQvF2= NYj4SoVUW0GQR1XS
SW1088 NYTQempYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\tTWM2OD1yLkS0N|kh|ryP NWWye|R1W0GQR1XS
SF268 M2X5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnSwTWM2OD1yLkS0PFYh|ryP M1XvUXNCVkeHUh?=
RT4 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNEWxNVEh|ryP M1vYTnNCVkeHUh?=
NCI-H522 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVexfIZMUUN3ME2wMlQ2OjdizszN NG\N[ZRUSU6JRWK=
LCLC-97TM1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwNE[xPVUh|ryP NYHPVYF6W0GQR1XS
CAL-39 M{G1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwNE[1NVkh|ryP MmDoV2FPT0WU
CAL-120 NGfLR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnTXW5MUUN3ME2wMlQ4PjR|IN88US=> M37ldXNCVkeHUh?=
ESS-1 M{nXXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwNEe4NlEh|ryP MmLsV2FPT0WU
KARPAS-45 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnv4TWM2OD1yLkS4PVM{KM7:TR?= NWXZSIp[W0GQR1XS
DU-4475 M1HTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\wTWM2OD1yLkS5OVEyKM7:TR?= MlLEV2FPT0WU
VMRC-RCZ NEHpdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3TcJpIUUN3ME2wMlQ6QTB2IN88US=> M2HrVXNCVkeHUh?=
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NCI-H2452 NX62[VN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm3Um9KSzVyPUGuPFkxPzRizszN NYDDZYpMW0GQR1XS
SK-MEL-2 NFHS[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnEOZlKSzVyPUGuPVAzPzFizszN MnTqV2FPT0WU
OVCAR-5 M4PVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwOUC2O|Uh|ryP NHfWSWJUSU6JRWK=
SNG-M MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHUO|RKSzVyPUGuPVU5PThizszN M3vpVnNCVkeHUh?=
A673 M3zZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwOUe1NVYh|ryP Mlz0V2FPT0WU
L-428 NWj1OlVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XNe2lEPTB;MT65PVE4QSEQvF2= MX3TRW5ITVJ?
KM-H2 Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\X[2lEPTB;Mj6wNVA6KM7:TR?= MX\TRW5ITVJ?
MC-IXC MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzPSFZ2UUN3ME2yMlAzOjd|IN88US=> NVrOeHp7W0GQR1XS
COLO-678 M4DaZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwMESyNFch|ryP M3TMN3NCVkeHUh?=
MEL-JUSO MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLCT2cyUUN3ME2yMlA4QDVzIN88US=> MnHZV2FPT0WU
HCC38 NWLm[4d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;jTWM2OD1{LkC4OFM{KM7:TR?= MYfTRW5ITVJ?
UACC-62 M{Drd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nLd2lEPTB;Mj6wPFg2PSEQvF2= NWCxPHRCW0GQR1XS
OAW-42 MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTiR|hkUUN3ME2yMlA6PzFzIN88US=> NGK4dnpUSU6JRWK=
LB996-RCC M1rv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK2TWM2OD1{LkGzPFE4KM7:TR?= NWHycXV[W0GQR1XS
COR-L105 NFXESXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rQfGlEPTB;Mj6xOlM4OyEQvF2= M3\qV3NCVkeHUh?=
RCC10RGB NXXwS3lDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJwMUi1O|Yh|ryP NXv6PHoyW0GQR1XS
A431 NVfoWYI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mxRWlEPTB;Mj6xPVAyQSEQvF2= NGX2NYZUSU6JRWK=
NCI-H292 NHu4c|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rXOGlEPTB;Mj6yN|k2OSEQvF2= MYrTRW5ITVJ?
SK-UT-1 NWPUcnpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHNTWM2OD1{LkOzNVg1KM7:TR?= NHj5RZlUSU6JRWK=
PANC-08-13 M{\yZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwM{OyN|Uh|ryP MlX4V2FPT0WU
ST486 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHoS4VzUUN3ME2yMlQyODR6IN88US=> MUjTRW5ITVJ?
SJSA-1 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHSW21KUUN3ME2yMlQyOjdzIN88US=> M33jPXNCVkeHUh?=
RKO MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkf1TWM2OD1{LkSyNFI6KM7:TR?= MkfFV2FPT0WU
NCI-H1793 NFHFeHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTJwNESwNlkh|ryP NUT3V|Z6W0GQR1XS
639-V M{LzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fVW2lEPTB;Mj60OVM5OiEQvF2= NEDOPXlUSU6JRWK=
ES3 NHzyfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJwNEm3N|ch|ryP NWDNSYtIW0GQR1XS
NCI-H1792 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUThTodJUUN3ME2yMlU3QDJ4IN88US=> MXjTRW5ITVJ?
NCI-H1651 M2LXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;Ib2lEPTB;Mj61PFIyKM7:TR?= MVjTRW5ITVJ?
SN12C M2rHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwNUi0PFch|ryP MlvLV2FPT0WU
COLO-679 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly3TWM2OD1{LkW4OlA2KM7:TR?= NIjtXlBUSU6JRWK=
U-118-MG M1mwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHkTWM2OD1{LkW4PFczKM7:TR?= M3;FPXNCVkeHUh?=
Ramos-2G6-4C10 NY\WZWF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXMTWM2OD1{Lk[0PFA4KM7:TR?= MmXaV2FPT0WU
HCT-15 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmeyTWM2OD1{Lk[4O|kzKM7:TR?= M2e2VXNCVkeHUh?=
MDA-MB-157 M{TvfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzKcldSUUN3ME2yMlcxPzR5IN88US=> NUTOPJpJW0GQR1XS
K5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwN{G4OFUh|ryP NW\qZ297W0GQR1XS
MKN45 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXub5JKSzVyPUKuO|M{PjZizszN NGry[5NUSU6JRWK=
DMS-273 NXjWXHhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJwN{W2N|Ih|ryP NGTmUpdUSU6JRWK=
C8166 M{HUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJwN{i1NVMh|ryP MWfTRW5ITVJ?
Calu-3 NFXBc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr3TWM2OD1{Lke4PVY6KM7:TR?= NWOxNoNRW0GQR1XS
SNB75 NXzTV3RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwOEi1N|Uh|ryP Mme0V2FPT0WU
BFTC-905 NH;MSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zs[GlEPTB;Mj65NFE6OSEQvF2= MlzHV2FPT0WU
C-4-II MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXjZZltUUN3ME2yMlkyOzV|IN88US=> NVvXeYJ1W0GQR1XS
MS-1 NH\HVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJwOU[3Olkh|ryP MVzTRW5ITVJ?
A375 NG\UfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTNwMEixPFQh|ryP NF;2[YRUSU6JRWK=
KYSE-70 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHCTWM2OD1|LkC4PFgzKM7:TR?= MV;TRW5ITVJ?
KYSE-510 NHfDWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;he2lEPTB;Mz6xNFk6PSEQvF2= NFGzdGFUSU6JRWK=
LN-405 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHwTWM2OD1|LkGzOVE5KM7:TR?= MnexV2FPT0WU
BOKU NWTUe3kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrmT2R6UUN3ME2zMlE1OjV4IN88US=> NFzVT3JUSU6JRWK=
TE-10 M2\vdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13J[2lEPTB;Mz6xO|M3OiEQvF2= MnexV2FPT0WU
MKN1 M3TCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M125V2lEPTB;Mz6xPFQ5OyEQvF2= MUfTRW5ITVJ?
M059J MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\6ZZRYUUN3ME2zMlIxOTd|IN88US=> NW\xOnozW0GQR1XS
GOTO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TySmlEPTB;Mz6yNlA{QSEQvF2= MVPTRW5ITVJ?
DK-MG MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml24TWM2OD1|LkK1PVc3KM7:TR?= NFvFfolUSU6JRWK=
NCI-H727 NEK4e3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO0PGVKSzVyPUOuNlY2QCEQvF2= M1[5WXNCVkeHUh?=
NB12 NHztNXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[w[WlEPTB;Mz6zN|IzPCEQvF2= Mor5V2FPT0WU
DOK NILKU|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFWzVI1KSzVyPUOuN|YyQDZizszN NXmyZVdTW0GQR1XS
KYSE-410 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moj5TWM2OD1|LkO2Nlg4KM7:TR?= MW\TRW5ITVJ?
AM-38 NILaUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XqRmlEPTB;Mz6zPFA2OSEQvF2= NXTpdml7W0GQR1XS
GR-ST M1XadGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXKxeIFIUUN3ME2zMlQ2PzN{IN88US=> NHKzbmNUSU6JRWK=
D-247MG MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrhTWM2OD1|LkS4NlY{KM7:TR?= Mon3V2FPT0WU
TE-8 NUnXe3htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml31TWM2OD1|LkS5N|M{KM7:TR?= M3TSNnNCVkeHUh?=
LS-411N NV3zdY1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNwNEm2PVIh|ryP MkK4V2FPT0WU
SK-MES-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13FfGlEPTB;Mz61OlQ{OyEQvF2= NWHNToNJW0GQR1XS
SF295 M2rYOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;OTWM2OD1|Lk[xOVUzKM7:TR?= NX7YWmlnW0GQR1XS
SK-MEL-30 M{jhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;MN|dKSzVyPUOuOlU6OjFizszN Mnr1V2FPT0WU
LB2241-RCC M1fXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLOe49KSzVyPUOuOlYzPiEQvF2= NF\vOWxUSU6JRWK=
PC-14 NFTye2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTNwNk[0N|ch|ryP MmLQV2FPT0WU
EW-7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37VZmlEPTB;Mz62O|Y6OyEQvF2= MVvTRW5ITVJ?
NMC-G1 NXnpRm13T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr2SG81UUN3ME2zMlcyQDN5IN88US=> NVX4cIY5W0GQR1XS
TE-441-T Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLtdJRKSzVyPUOuO|MxOjhizszN MUjTRW5ITVJ?
NCI-H1618 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPNTWM2OD1|LkixPFc2KM7:TR?= M4HXVXNCVkeHUh?=
PANC-03-27 M{DXOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPhSlk2UUN3ME2zMlgyQTF4IN88US=> MYLTRW5ITVJ?
NCI-H2228 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjocFRKSzVyPUOuPFMyOjZizszN NV7Td2l7W0GQR1XS
CAPAN-1 M2\Me2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrBT4dKSzVyPUOuPFcxODlizszN MYfTRW5ITVJ?
KLE MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\oTWM2OD1|LkmwOlch|ryP MkDTV2FPT0WU
Becker NIjlSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHkU|FqUUN3ME2zMlkzQDR7IN88US=> NGHJSndUSU6JRWK=
SK-PN-DW NICwdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXrNVFKSzVyPUSuNFc6PzRizszN MkXqV2FPT0WU
Hs-578-T NXvnWWZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwMEizNFYh|ryP NWfidYxlW0GQR1XS
RS4-11 NYDGd|lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVixdnNvUUN3ME20MlEyOjV3IN88US=> M1vDSnNCVkeHUh?=
D-502MG NGTxZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfUSIxyUUN3ME20MlE3QTl5IN88US=> MUTTRW5ITVJ?
GI-1 MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPzSWZKSzVyPUSuNlgzQTlizszN Mnz5V2FPT0WU
NCI-H209 NXfNSJNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;TcmlEPTB;ND6zN|c5KM7:TR?= NX\aPItUW0GQR1XS
SK-OV-3 NETiT|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rkW2lEPTB;ND60PFE1QSEQvF2= MXzTRW5ITVJ?
LOUCY NU\Ub455T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwNEi0N|Ih|ryP M2faOnNCVkeHUh?=
NCI-H69 M17zcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK3WGNKSzVyPUSuOVE4QTNizszN NFzJfIFUSU6JRWK=
SCC-9 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\SUlFKSzVyPUSuOVMyPzJizszN NYi0bnNWW0GQR1XS
NCI-H526 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnGdJo{UUN3ME20MlU6Ojl|IN88US=> NVXYXYYyW0GQR1XS
NCI-H2170 M3X4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXzfmF5UUN3ME20MlY3PzdzIN88US=> NXqw[ZZPW0GQR1XS
SR NXK1RVJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnOPVNvUUN3ME20MlcxODR6IN88US=> M4fxVnNCVkeHUh?=
CMK M3W0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjkdYRKSzVyPUSuO|IyODFizszN MX7TRW5ITVJ?
COLO-829 NHXEcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzuTWM2OD12Lke3NFQ{KM7:TR?= M3PYO3NCVkeHUh?=
HuO-3N1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwOEOyPFEh|ryP Ml\FV2FPT0WU
5637 NIrBe29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjjSWRKSzVyPUSuPVA1QDdizszN NFjKRlVUSU6JRWK=
A253 MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTRwOUe3NFgh|ryP NEDtZY5USU6JRWK=
NB10 NGHaWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq5PYFKSzVyPUWuNFc1QTdizszN MULTRW5ITVJ?
SF539 M4H2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTVwMEm5OVkh|ryP MUjTRW5ITVJ?
HAL-01 M4DHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfBOVBKSzVyPUWuNVQ3PDVizszN MlXLV2FPT0WU
MHH-ES-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTVwMU[5NlUh|ryP NXLab25XW0GQR1XS
DEL NH3XeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPMb5VKSzVyPUWuNlc2QDJizszN M13wRnNCVkeHUh?=
NCI-H1299 MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTVwM{WwNFch|ryP MWHTRW5ITVJ?
ChaGo-K-1 NXn3d4htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPZTWM2OD13LkO1NVA4KM7:TR?= NWPaSXNOW0GQR1XS
HMV-II M1v5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\1TWM2OD13LkO5OFMh|ryP NYH2cmtbW0GQR1XS
NB69 M1PDPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknkTWM2OD13LkO5OlMyKM7:TR?= NXruU4ZWW0GQR1XS
NCI-H1882 NGS3VYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3GeoNqUUN3ME21MlQ{OzZ2IN88US=> NIizfW5USU6JRWK=
SNU-475 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnaTWM2OD13LkS3NVcyKM7:TR?= MmDNV2FPT0WU
RXF393 M4joeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M163PWlEPTB;NT60PFQ6PCEQvF2= NXvFeIZIW0GQR1XS
CAL-51 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHRTWM2OD13Lk[yPFU{KM7:TR?= NETuXlVUSU6JRWK=
SW1573 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnDW4VKSzVyPUWuOlM2OzRizszN MYPTRW5ITVJ?
GCT Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDpTWM2OD13Lke1PVI6KM7:TR?= NVzIW3h5W0GQR1XS
COR-L88 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3L4WGlEPTB;NT63Olg1PiEQvF2= MWLTRW5ITVJ?
MDA-MB-134-VI MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXeyd5l4UUN3ME21Mlg4PTN4IN88US=> NGPzSm1USU6JRWK=
NB5 M4LrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXLOIVKSzVyPUWuPVI1PCEQvF2= MkfOV2FPT0WU
GMS-10 NXvafmdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTVwOU[4OlEh|ryP MXfTRW5ITVJ?
CHP-212 NXzoVYtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXEZXB[UUN3ME22MlQ5OjZ5IN88US=> M3PpNnNCVkeHUh?=
TE-11 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTZwNUWxPFIh|ryP M1LSNnNCVkeHUh?=
SW962 NFjNNJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTIS5NKSzVyPU[uOlU4PzRizszN MnfBV2FPT0WU
MZ2-MEL NV\KVYZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV2zV286UUN3ME22MlgzODFzIN88US=> M2LnWHNCVkeHUh?=
C-33-A NI[1XGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TCN2lEPTB;Nj65NVY5QCEQvF2= M3\OTnNCVkeHUh?=
IGR-1 MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTZwOUe4NlYh|ryP NEH0TVFUSU6JRWK=
MOLT-4 NF;RemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOzTWM2OD15LkG1OFA3KM7:TR?= MnrQV2FPT0WU
NCI-H1650 NX3HWmZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fFc2lEPTB;Nz6yO|A1PiEQvF2= MnnYV2FPT0WU
AsPC-1 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK0TWM2OD15LkK4OlA2KM7:TR?= M3LIdnNCVkeHUh?=
SNU-C2B MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX5T3VKSzVyPUeuNlk2PzFizszN NIC3eoFUSU6JRWK=
MKN7 NGDDdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\MWWlEPTB;Nz6zO|I{PSEQvF2= NEDI[lNUSU6JRWK=
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TE-6 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLlPZMyUUN3ME23MlQ1QTB6IN88US=> MoPuV2FPT0WU
D-263MG NFP4U2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTdwNEW3OlIh|ryP NFrGOWtUSU6JRWK=
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NCI-H1993 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOx[mlRUUN3ME2xNE42Pjl|IN88US=> MmC3V2FPT0WU
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Daoy NHP5[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXja[GFEUUN3ME2xNU41OzN4IN88US=> MWnTRW5ITVJ?
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DB MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlexTWM2OD1{MT62NVQzKM7:TR?= MkTnV2FPT0WU
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LU-165 M1\oRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOyeJVXUUN3ME2yNk42PTRizszN MkL3V2FPT0WU
COLO-792 Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jReWlEPTB;MkKuO|EyOSEQvF2= MkDhV2FPT0WU
CAL-62 NHvPNnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXqTWM2OD1{Mj63OVE4KM7:TR?= NGnWSpNUSU6JRWK=
HCE-T NVfMNGU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;4OlI2UUN3ME2yNk45PjB4IN88US=> MWHTRW5ITVJ?
BB65-RCC MkXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M360U2lEPTB;MkOuNFM1PCEQvF2= M1y1VHNCVkeHUh?=
SiHa NIHp[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL0TWM2OD1{Mz6zPVY5KM7:TR?= NVHOS2c{W0GQR1XS
NCI-H2081 M4T4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILaSopKSzVyPUK0MlA3PDFizszN M1T1PXNCVkeHUh?=
U251 NFPpW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PXWmlEPTB;MkSuNFY3QCEQvF2= MkDWV2FPT0WU
LoVo NX3Ge4tkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzYZ3ZKSzVyPUK0MlkzQDJizszN MUHTRW5ITVJ?
GCIY MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\0TWM2OD1{NT6yPFc4KM7:TR?= NWHId2E{W0GQR1XS
NUGC-3 NWXVSZY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ3LkOzNVYh|ryP NVi2OFhlW0GQR1XS
LNCaP-Clone-FGC NEi3PVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXriVmR2UUN3ME2yOU4{PDl6IN88US=> NWfRb2h[W0GQR1XS
PA-1 NUj0TZZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzX[3VsUUN3ME2yOU43QDN|IN88US=> M1fienNCVkeHUh?=
OE33 MmC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnaboJxUUN3ME2yOU43QDV|IN88US=> NGL0Xo5USU6JRWK=
HT-29 M33USGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ3Lke4O|kh|ryP MVPTRW5ITVJ?
RCM-1 MkjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjme4xmUUN3ME2yOU46PjV4IN88US=> MYnTRW5ITVJ?
NCI-H1522 M2r1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTTTWM2OD1{NT65PVEyKM7:TR?= M{\McHNCVkeHUh?=
LB373-MEL-D NWHObY5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJ4LkG3NFgh|ryP M1fwN3NCVkeHUh?=
NCI-H1436 NITGTVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHny[mtKSzVyPUK2MlI4OzhizszN Ml:zV2FPT0WU
COLO-824 NXXuVnNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXOPGtKSzVyPUK2MlQxODJizszN M1rx[3NCVkeHUh?=
CP50-MEL-B NED2dHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvlSo9KSzVyPUK2MlU3PzVizszN M{C0cXNCVkeHUh?=
EGI-1 NHrI[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJ5LkK2PVgh|ryP MmLCV2FPT0WU
LAN-6 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTYUmpEUUN3ME2yO{4{PTl6IN88US=> NFv4e5VUSU6JRWK=
GAK NY\Cc2MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfUXYFGUUN3ME2yO{41OjJ3IN88US=> NWHiS4FEW0GQR1XS
MDA-MB-175-VII MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP2b4tKSzVyPUK3MlUxPTNizszN M4n6XHNCVkeHUh?=
JVM-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nTPGlEPTB;MkeuOlYzOiEQvF2= NEP4[WFUSU6JRWK=
UACC-257 M1HvWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrtU3VKSzVyPUK3MlY5PzhizszN MXvTRW5ITVJ?
SW1783 M1TLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjDVnZKSzVyPUK3Mlc4QDNizszN M4OxdXNCVkeHUh?=
HT-3 NETYOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJ6LkKxOlYh|ryP M3X0ZXNCVkeHUh?=
RL NYLYb5c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTXTWM2OD1{OD61PVEyKM7:TR?= MXnTRW5ITVJ?
TK10 NVe0SHdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\kPWlEPTB;MkiuOlU{PSEQvF2= NF;ZRoVUSU6JRWK=
HT55 M2nOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorYTWM2OD1{OT6wOVY2KM7:TR?= MXrTRW5ITVJ?
BT-20 M{Dod2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPUblRWUUN3ME2yPU4xPTh4IN88US=> Mnv6V2FPT0WU
TGBC24TKB NYDaeHdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jrcmlEPTB;MkmuNVg{OSEQvF2= NVH2bGQ5W0GQR1XS
HSC-2 NVrvVoRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKwTWM2OD1{OT6zNFAyKM7:TR?= MmDLV2FPT0WU
COLO-205 NXe0T|l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXGTJVkUUN3ME2yPU4{QTR2IN88US=> MnvkV2FPT0WU
GT3TKB NUXEXYVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HmVGlEPTB;MkmuOlg4PyEQvF2= MX3TRW5ITVJ?
T47D MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDsTWM2OD1{OT64OVgzKM7:TR?= MV3TRW5ITVJ?
OMC-1 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzoXGp[UUN3ME2zNE4yQTF7IN88US=> MWrTRW5ITVJ?
PFSK-1 M1[1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi4TWM2OD1|MT6yOlU6KM7:TR?= M1LYWnNCVkeHUh?=
JEG-3 Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTNzLkO1OlEh|ryP M1O1fXNCVkeHUh?=
RD MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy5[Vd6UUN3ME2zNU42OTF3IN88US=> NIOwRYRUSU6JRWK=
NCI-H64 NHrLWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W3S2lEPTB;M{KuOFE4QSEQvF2= MUHTRW5ITVJ?
DMS-114 NX3nd|JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN{LkSxPFIh|ryP M3GxdnNCVkeHUh?=
NCI-H661 MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTN{Lk[1NFEh|ryP MWHTRW5ITVJ?
CAL-148 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTN{Lk[2OlUh|ryP M3u4RnNCVkeHUh?=
HuP-T3 NV;qNXAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN{LkmzN|gh|ryP NHLZRpdUSU6JRWK=
ES4 NYnqVpROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnr[XdKSzVyPUOzMlE4ODVizszN M1\nSXNCVkeHUh?=
Ca9-22 M1uxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXCTWM2OD1|Mz60OlAyKM7:TR?= NV7CPGxIW0GQR1XS
LP-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\IfI1KSzVyPUO0MlA6KM7:TR?= MlW5V2FPT0WU
AU565 M1rjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G1SmlEPTB;M{SuOVA3QSEQvF2= M1T5eXNCVkeHUh?=
MDA-MB-453 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTN3LkG0NlYh|ryP MlzlV2FPT0WU
SNU-C1 NWiwWmlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjGTWM2OD1|NT6xO|Eh|ryP NUXOR2NoW0GQR1XS
SW13 M1PGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG2TWM2OD1|NT60NFc3KM7:TR?= NEXp[HRUSU6JRWK=
NCI-H2122 MojSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET0fY9KSzVyPUO1MlU2QThizszN NVrrVnZDW0GQR1XS
NCI-H1395 MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHrTWM2OD1|NT62OlkyKM7:TR?= NVnUZ5VIW0GQR1XS
J-RT3-T3-5 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN4LkCyPVQh|ryP NYXPcJZmW0GQR1XS
COR-L279 M1XE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vsRWlEPTB;M{[uNVk5OSEQvF2= Mnq1V2FPT0WU
ATN-1 M1jZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXud4lKSzVyPUO2Mlg2OTZizszN MnjvV2FPT0WU
HCC2998 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLQTWM2OD1|Nj64OVcyKM7:TR?= MnuxV2FPT0WU
UM-UC-3 M4fDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fKNGlEPTB;M{[uPFY4PSEQvF2= NHrtdllUSU6JRWK=
DV-90 NEnhc|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37J[WlEPTB;M{[uPVA3PyEQvF2= MYHTRW5ITVJ?
ES8 NWnMOYtST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:yZ2lEPTB;M{[uPVMyQCEQvF2= M33JOnNCVkeHUh?=
YAPC NGrKV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXCZ5YzUUN3ME2zOk46PjV2IN88US=> M3fqdXNCVkeHUh?=
HCC1599 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLHRY1sUUN3ME2zO{4yPjF6IN88US=> MljMV2FPT0WU
UMC-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XmbWlEPTB;M{euNlUxOyEQvF2= MUXTRW5ITVJ?
THP-1 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojXTWM2OD1|Nz6yPFY5KM7:TR?= MnPEV2FPT0WU
OCUB-M MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jrOGlEPTB;M{euNlg6OSEQvF2= NFTlNXBUSU6JRWK=
NCI-H1693 NEfybJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXNTWM2OD1|Nz6zNlM{KM7:TR?= M4nad3NCVkeHUh?=
NCI-H345 M374[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknCTWM2OD1|Nz6zOlI1KM7:TR?= MlzPV2FPT0WU
COLO-800 M2jaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPoTWM2OD1|Nz61Olch|ryP NYLm[pJSW0GQR1XS
COLO-320-HSR MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LmU2lEPTB;M{iuN|Q6OiEQvF2= Ml;3V2FPT0WU
NCI-H596 NEX1fZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN6LkS0PFkh|ryP Ml;nV2FPT0WU
NCI-H187 NXXEOGQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTN6LkezOFQh|ryP NYfmfGhzW0GQR1XS
ECC4 MlnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHJTWM2OD1|OT6wPFE1KM7:TR?= NEW5RmlUSU6JRWK=
KP-4 M2fm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvjPYpKSzVyPUO5MlEzOzVizszN M{joenNCVkeHUh?=
NCI-H2227 MkS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7WbVhsUUN3ME2zPU4{QTR7IN88US=> NGHhNlRUSU6JRWK=
22RV1 M{fRRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HHZWlEPTB;M{muPFM6QCEQvF2= NUPucHplW0GQR1XS
SAS MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DpbGlEPTB;NECuNFk3KM7:TR?= MkfhV2FPT0WU
PANC-10-05 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj6TWM2OD12MD6xPFI5KM7:TR?= MlTJV2FPT0WU
MDA-MB-468 NGC5NphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHHWVdKSzVyPUSwMlU{PDZizszN MkXiV2FPT0WU
RPMI-7951 NGDEOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz2SodCUUN3ME20NU4zODd3IN88US=> NIDONW5USU6JRWK=
BB49-HNC M2Xpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTRzLkKxO|kh|ryP NYn4bFd3W0GQR1XS
23132-87 M3m0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTRzLkK3N|Ih|ryP NHLjR4hUSU6JRWK=
HCC1569 MlLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH2TmN3UUN3ME20NU4zQDh3IN88US=> NHPNe4JUSU6JRWK=
CP66-MEL MnzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWi0WVdjUUN3ME20Nk4yQDh4IN88US=> NFvnPGZUSU6JRWK=
K-562 NGnLXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfqTWM2OD12Mj6yPFU1KM7:TR?= MXrTRW5ITVJ?
OCI-AML2 NEDBOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXGTWM2OD12Mj64PVc1KM7:TR?= MYTTRW5ITVJ?
SW756 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrZfHVKSzVyPUSzMlA{QDhizszN NEPDcJpUSU6JRWK=
M14 NUXWVVY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzjRpVWUUN3ME20N{4{OTh7IN88US=> MlS5V2FPT0WU
NCI-H1623 M2L6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jmXGlEPTB;NEOuOFY1KM7:TR?= M1;LenNCVkeHUh?=
KNS-81-FD NXjlemJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfROFdKSzVyPUSzMlc3OiEQvF2= NX7DcllZW0GQR1XS
TGBC1TKB MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIC5XoZKSzVyPUSzMlkxQTlizszN NGC5SFlUSU6JRWK=
RERF-LC-MS NXTncI1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PBZ2lEPTB;NEOuPVI5OSEQvF2= NWG2bJBTW0GQR1XS
PC-3 NISwdIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH21V4xKSzVyPUS0MlQ{PDdizszN NYrDTpd[W0GQR1XS
HuP-T4 NUHFNWdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ftNGlEPTB;NESuOFQ4PCEQvF2= M1LnUHNCVkeHUh?=
NCI-H510A M1jDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzvV5dlUUN3ME20OE44ODhizszN MUPTRW5ITVJ?
LB2518-MEL NIT2PWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUH1ZYc3UUN3ME20OE44QTN5IN88US=> MlP6V2FPT0WU
TE-5 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTR3Lkm1PFEh|ryP NFza[VVUSU6JRWK=
EW-24 M1zBVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR4LkG3NlMh|ryP MofOV2FPT0WU
LB647-SCLC NEXQdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLFTWM2OD12Nj6yNVU2KM7:TR?= Mme3V2FPT0WU
NCI-H524 NFvCU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfVd|BEUUN3ME20Ok44OTh3IN88US=> MXfTRW5ITVJ?
EW-11 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\3UFJKSzVyPUS2Mlk{PzNizszN M4fOS3NCVkeHUh?=
KALS-1 NUPSfnA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\u[5QzUUN3ME20O{4zODZ4IN88US=> NGHWe|RUSU6JRWK=
BT-474 MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTR5LkSyNVYh|ryP NFm0cmVUSU6JRWK=
SK-N-AS M33uW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDkdotKSzVyPUS3Mlg5QCEQvF2= MX7TRW5ITVJ?
HCC2157 NGrmeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTR6LkC3OkDPxE1? MnntV2FPT0WU
HCC1954 M4XNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTR6LkG3NFQh|ryP MmrCV2FPT0WU
FADU M2DWNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DOUWlEPTB;NEiuN|A{OSEQvF2= NIHPUmdUSU6JRWK=
S-117 M{fQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHiTWM2OD12OD6zPFE2KM7:TR?= NEjhNoRUSU6JRWK=
LS-1034 NFXpSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTR6LkewOlch|ryP NIjNPW5USU6JRWK=
CAMA-1 NXfVdnR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG1TWM2OD12OT61OVQ{KM7:TR?= MkPEV2FPT0WU
LU-134-A NGe1cI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe2[mRrUUN3ME20PU45ODh3IN88US=> M2LMfHNCVkeHUh?=
NCI-H1838 NXTwN5c2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTR7LkiwPFch|ryP M4\GW3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo In a mouse xenograft model of Ba/F3 cells expressing native Bcr-Abl, AP24534 (2.5 mg/kg and 5 mg/kg) prolongs mice median survival. In the xenograft model of Ba/F3 Bcr-AblT315I, AP24534 (10 mg/kg–50 mg/kg) significantly suppresses tumor growth. AP24534 (30 mg/kg) decreases the phosphorylated Bcr-Abl and phosphorylated CrkL levels in the tumors. [2]

Protocol

Kinase Assay:[1]
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Peptide substrate phosphorylation assays with GST-Abl kinase domains:

The effect of AP24534 (0-320 nM) on GST-Abl kinase activity is assessed by using a synthetic peptide substrate (Abltide: EAIYAAPFAKKK). Assays are carried out at 30 °C for 15 min in 25 μL reaction mixture: 8 mM MOPS (pH 7), 0.2 mM EDTA, 50 μM Abltide, 30 mM MgCl2, 10 mM β-glycerol phosphate, 1 mM EGTA, 0.002% Brij-35, 0.4 mM DTT, 0.2 mg/mL BSA, 0.4 mM sodium orthovanadate, 10 nM WT or mutant GST-Abl kinase, and 100 µM ATP/γ-32[P]ATP (5000 cpm/pmol). Reactions are terminated by transferring a portion of the reaction mixture onto a p81 phosphocellulose filter and immersing in 0.75% phosphoric acid. Filters are washed 3 times in 0.75% phosphoric acid, rinsed in acetone, and air dried; phosphate incorporation is determined by scintillation counting. All results are corrected for background binding to the filters, as determined by omitting peptide substrate from the kinase reaction. Time course experiments to establish the linear range of enzymatic activity precedes kinase assays.
Cell Research:[2]
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  • Cell lines: Ba/F3 cells expressing Bcr-Abl or a range of single mutations in the kinase domain of Bcr-Abl
  • Concentrations: 0-625 nM
  • Incubation Time: 72 hours
  • Method: Ba/F3 cell lines are distributed in 96-well plates (4 × 103 cells/well) and incubated with AP24534 for 72 hours. Proliferation is measured using a methanethiosulfonate (MTS)-based viability assay (CellTiter96 Aqueous One Solution). All values are normalized to the control wells with no drug. IC50 values are reported as the mean of three independent experiments performed in quadruplicat
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mouse xenograft models of Ba/F3 cells expressing Bcr-Abl or Bcr-AblT315I
  • Formulation: Dissolved in 25 mM citrate buffer, pH 2.75
  • Dosages: 2.5 mg/kg and 5 mg/kg for Ba/F3 Bcr-Abl; 2.5 mg/kg–50 mg/kg for Ba/F3 Bcr-AblT315I
  • Administration: Oral gavage once daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (56.33 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% CMC Na
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 532.56
Formula

C29H27F3N6O

CAS No. 943319-70-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03709017 Recruiting Chronic Myeloid Leukemia|Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia Korea Otsuka Pharmaceutical Co. Ltd. October 2018 --
NCT03690115 Not yet recruiting Leukemia Myeloid Acute Versailles Hospital October 2018 Phase 2
NCT03704688 Recruiting Non Small Cell Lung Cancer|KRAS Gene Mutation Memorial Sloan Kettering Cancer Center October 9 2018 Phase 1|Phase 2
NCT03589326 Recruiting Lymphoblastic Leukemia Acute Adult|Acute Lymphoid Leukemia|Leukemia Acute Lymphoblastic|Leukemia Lymphoblastic|Ph1 Chromosome|Leukemia Lymphoblastic Acute Philadelphia-Positive Millennium Pharmaceuticals Inc.|Takeda August 10 2018 Phase 3
NCT03576547 Recruiting Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Recurrent Chronic Myelogenous Leukemia BCR-ABL1 Positive|Refractory Acute Lymphoblastic Leukemia|Refractory Chronic Myelogenous Leukemia BCR-ABL1 Positive|t(9;22) M.D. Anderson Cancer Center|National Cancer Institute (NCI) June 26 2018 Phase 1|Phase 2
NCT03147612 Recruiting Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia With BCR-ABL1|Philadelphia Chromosome Positive|Recurrent Acute Lymphoblastic Leukemia|Refractory Acute Lymphoblastic Leukemia M.D. Anderson Cancer Center|National Cancer Institute (NCI) February 8 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Is the pre-solubilized inhibitor suitable for in vivo whole animal studies? Whether the solvent contains any non-DMSO stabilizer?

  • Answer:

    Our 10mM Ponatinib in DMSO solution is in pure DMSO and there is not other stabilizer added. You can use it for animal study. The vehicle we suggest for Ponatinib is: 30% PEG400/0.5% Tween80/5% Propylene glycol. It is a milky suspension used for oral gavage.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID