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Obeticholic Acid

For research use only.

Catalog No.S7660 Synonyms: INT-747, 6-ECDCA

11 publications

Obeticholic Acid Chemical Structure

CAS No. 459789-99-2

Obeticholic Acid (INT-747, 6-ECDCA) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.

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Selleck's Obeticholic Acid has been cited by 11 publications

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  • (c) Functional bile canaliculi or lack thereof in PHHs within MPTCs (12 d of drug treatment) as visualized by transport of fluorescent (green) dye into the canaliculi between PHHs. DMSO-treated MPCC control image is shown to the far right. (d) Neutral lipid (Nile red, green) staining of PHHs within MPTCs (12 d of drug treatment). DMSO-treated MPCC control image is shown to the far right. (e) NR1I2 (PXR) gene expression in drug-treated MPTCs relative to DMSOtreated MPTC controls (12 d of treatment). (f) ABCC2 (MRP2) gene expression in drug-treated MPTCs relative to DMSO-treated MPTC controls (12 d of treatment). (g) IL-6 levels in drug-treated MPTC supernatants (6 d of treatment). In all panels, statistical significance is displayed relative to DMSO-treated MPTCs. *p r 0.05, **p r 0.01, ***p r 0.001, and ****p r 0.0001. Scale bars on images represent 80 mm.

    Integr Biol (Camb), 2017, 9(8):662-677. Obeticholic Acid purchased from Selleck.

    HuCCT1 cells were treated with OCA (1 μM) and control solvent in the presence and absence of IL-6 (20 ng/mL). EMT-related proteins were examined by western blotting. β-actin was used as a control.

    Cell Physiol Biochem, 2018, 48(1):158-172. Obeticholic Acid purchased from Selleck.

  • (D) Expression of hepatic FXR target genes, n = 3. Data are expressed as mean ± SD, ###P < 0.001 versus group 1, *P < 0.05, **P < 0.01, and ***P b 0.001 versus group 2, sP < 0.05, ssP < 0.01, and sssP < 0.001 versus group 3

    Toxicol Appl Pharmacol, 2017, 315:23-34. Obeticholic Acid purchased from Selleck.

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Biological Activity

Description Obeticholic Acid (INT-747, 6-ECDCA) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.
Targets
FXR [1]
99 nM(EC50)
In vitro

In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells NFPmcnhHfW6ldHnvckBie3OjeR?= NGT5PYYyKGi{ MnHjRYdwdmm|dDDhZ5Rqfmm2eTDheEBz\WOxbXLpcoFvfCCqdX3hckBIW1RvdHHn[4VlKE[[UjDsbYdidmRiYnnu[Ilv\yCmb33hbY4hMDF7MzD0c{A1PzJicnXzbYR2\XNrIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCrboPlZ5Qh[2WubIOgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIHnueIVz[WO2aX;uJJdqfGhiYnnveIlvKGyjYnXscIVlKFOUQz2xJIFnfGW{IEGgbJIh[nliSGTSSkBie3OjeTygSWM2OCB;IECuNFEh|ryPLh?= M1vGfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS4PFA3Lz5{OUG0PFgxPjxxYU6=
HEK293T MmXaSpVv[3Srb36gZZN{[Xl? NVvmSolDOjRiaILz NIn4e2pC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGZZWiCneIDy[ZN{\WRiaX6gTGVMOjl|VDDj[YxteyCjc4Pld5Nm\CCjczDCV2VRKHC{b33veIVzKGS{aY\lckBk\WyudXzhdkB1emGwc3PybZB1cW:wYXygZYN1cX[rdImgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvODR{IN88UU4> NVLOVnNIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxOFg5ODZpPkK5NVQ5QDB4PD;hQi=>
COS1 MUHGeY5kfGmxbjDhd5NigQ>? M2j5[mFod26rc4SgZYN1cX[rdImgZZQhTliUIHX4dJJme3OnZDDpckBEV1NzIHPlcIx{KGK7IHPlcIwu[mG|ZXSgZolwdHWvaX7ld4NmdmOnIHHzd4F6NCCHQ{WwJF0hOC5yOUmg{txONg>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODBzNEi3NEc,OjByMUS4O|A9N2F-
HeLa M{P5NWZ2dmO2aX;uJIF{e2G7 MXWyOEBpenN? MnqwRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDmeYxtKGynbnf0bEBHYFJiZYjwdoV{e2WmIHnuJGhmVGFiY3XscJMh[2:2cnHud4Zm[3SnZDD3bZRpKHCVR{WtbJVu[W5iUmjSJIFnfGW{IEK0JIhzeyCkeTDEeYFtNUeubzDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjF4IN88UU4> MnPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7M{SyNlcoRjJ3OUO0NlI4RC:jPh?=
HeLa MkexSpVv[3Srb36gZZN{[Xl? NV\FSoh5SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBHYFJiZYjwdoV{e2WmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhemWlZYD0c5Ih[WO2aY\heIlwdiCkeTDCV2VRKHC{b33veIVzNWS{aY\lckBncXKnZnz5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwMU[g{txONg>? NFTERmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK1OVA{QSd-MkWyOVUxOzl:L3G+
insect cells NEfPXppHfW6ldHnvckBie3OjeR?= M2jH[|EhcHJ? MlrsRYdwdmm|dDDhZ5Rqfmm2eTDheEBz\WOxbXLpcoFvfCCqdX3hckBIW1RvdHHn[4VlKE[[UjDMRmQhMDF7MzD0c{A1PzJicnXzbYR2\XNrIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2ey2rbn\lZ5Rm\CCrboPlZ5Qh[2WubIOgZZN{\XO|ZXSgZZMhemWlcoXpeI1mdnRib3[gZolwfGmweXzheIVlKFOUQ{GgdIVxfGmmZTDt[YF{fXKnZDDh[pRmeiBzIHjyJIJ6KEGucHjhd4Nz\WWwIHHzd4F6NCCHQ{WwJF0hOC5zODFOwG0v NIjBW|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUK1PVc1Oid-MkmyOVk4PDJ:L3G+
COS1 NVTteWw1TnWwY4Tpc44h[XO|YYm= Mmi2OUBpenN? NWPWdFV5SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBHYFJiZYjwdoV{e2WmIHnuJGNQWzFiY3XscJMh[W[2ZYKgOUBpenNiYomgR3JGNWS{aY\lckBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkO2NUDPxE1w MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ6NU[wN{c,OTd4OEW2NFM9N2F-
CHO MVrGeY5kfGmxbjDhd5NigQ>? NV7nVY5IPSCqcoO= NXXN[YJGSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[W[2ZYKgOUBpenNiYomgR3JGNWS{aY\lckBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLke1OUDPxE1w NUH6NY91RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PFU3ODNpPkG3Olg2PjB|PD;hQi=>
HEK293 MnHLSpVv[3Srb36gZZN{[Xl? MX2xJIhz NY\PTItoSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDjRW1RKGyndnXsJIFnfGW{IEGgbJIh[nliVGKtSnJGXCCjc4PhfUwhTUN3MDC9JFAvQDRizszNMi=> MkHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{NUm3OFIoRjJ7MkW5O|QzRC:jPh?=
NCI-H716 M{TGcGZ2dmO2aX;uJIF{e2G7 NELZcplC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRIWjVicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJG5EUS2KN{G2JINmdGy|IHHzd4V{e2WmIHHzJIlvfHKjY3XscJVt[XJiY1HNVEBt\X[nbDDifUBVWi2IUlXUJIF{e2G7LDDFR|UxKD1iMkCg{txONg>? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3OUW4NEc,OjF2NUm1PFA9N2F-
HepG2 NYT3U3VHTnWwY4Tpc44h[XO|YYm= M{DOe|IxKHWP MU\JcoR2[3Srb36gc4YhTliULX3l[IlifGWmIGPIVEBuWk6DIHX4dJJme3Orb36gbY4hcHWvYX6gTIVxTzJiY3XscJMh[XRiMkCgeW0h[nliUmStVGNT NV;4eohyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVk2QDBpPkKxOFU6PThyPD;hQi=>
HepG2 MV3GeY5kfGmxbjDhd5NigQ>? MmfrNUB2VQ>? NXnYXGpHUW6mdXP0bY9vKG:oIF\YVk1u\WSrYYTl[EBUUFBibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFEhfU1iYomgVnQuWEOU NHLzO|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1PVU5OCd-MkG0OVk2QDB:L3G+
HepG2 NG[1WWNHfW6ldHnvckBie3OjeR?= NH\M[pIzOCC3TR?= MWTJcoR2[3Srb36gc4YhTliULX3l[IlifGWmIFLTSXAhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEKwJJVOKGK7IGLUMXBEWg>? M3jMTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MUDGeY5kfGmxbjDhd5NigQ>? MXiyNEB2VQ>? M324bWlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgU5N1[mW2YTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOjBidV2gZpkhWlRvUFPS MmLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 MXLGeY5kfGmxbjDhd5NigQ>? NYPSNopiOSC3TR?= NFfKNmJKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJIRwf25vcnXneYxifGmxbjDv[kBEgXB5QUGgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFidV2gZpkhWlRvUFPS NIiwOpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1PVU5OCd-MkG0OVk2QDB:L3G+
HepG2 M3zuWmZ2dmO2aX;uJIF{e2G7 NInwfXgzOCC3TR?= NGLVU3ZKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJIRwf25vcnXneYxifGmxbjDv[kBEgXB5QUGgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDJyIIXNJIJ6KFKWLWDDVi=> M1LLd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MnLYSpVv[3Srb36gZZN{[Xl? MojGNlAhfU1? MWjB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIF\YVkBmgHC{ZYPz[YQhcW5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMhemWwaXzsZUBtfWOrZnXyZZNmKGGldHn2bZR6KGG2IEKwJJVOKGK7IHz1Z4ln\XKjc3WgZoF{\WRidILhcpNi[3SrdnH0bY9vKGG|c3H5 M{HSVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MofYSpVv[3Srb36gZZN{[Xl? MWexJJVO MoHpTY5lfWO2aX;uJI9nKE[[Uj3t[YRq[XSnZDDCV2VRKG2UTlGg[ZhxemW|c3nvckBqdiCqdX3hckBJ\XCJMjDj[YxteyCjdDCxJJVOKGK7IGLUMXBEWg>? M{HYe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 NE\NRo9HfW6ldHnvckBie3OjeR?= NEG4R2YyKHWP MYPJcoR2[3Srb36gc4YhTliULX3l[IlifGWmIF;zeIJmfGFibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFEhfU1iYomgVnQuWEOU MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3OUW4NEc,OjF2NUm1PFA9N2F-
HepG2 MYrGeY5kfGmxbjDhd5NigQ>? M{nhVVExKHWP MXjUdoFve2GldHn2ZZRqd25ib3[gbJVu[W5iRmjSJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFExKHWPIHL5JIJmfGFvZ3HsZYN1d3OrZHHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 NX;3[pNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzPFc{OjVpPkK0N|g4OzJ3PD;hQi=>
HepG2 MX7GeY5kfGmxbjDhd5NigQ>? NVvQVpp[OTBidV2= MWKxPEBpenN? NH;ZeFhC\2:waYP0JIFkfGm4aYT5JIF1KE[[UjDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YhV1OWLXHsdIhiKG2UTlGg[ZhxemW|c3nvckBifCBzMDD1UUBi\nSncjCxPEBpenNiYomgVnQuWEOUIHHuZYx6e2m| NYLTfYRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzPFc{OjVpPkK0N|g4OzJ3PD;hQi=>
GLUTag MoL4SpVv[3Srb36gZZN{[Xl? M3PQSmFod26rc4SgZYN1cX[rdImgZZQhT1BvQlHSNUBqdiCvb4Xz[UBIVFWWYXegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDjRW1RKGyndnXs MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 NIPEXWNHfW6ldHnvckBie3OjeR?= MVexNEB2VQ>? NEH3THYyQCCqcoO= MXPB[49vcXO2IHHjeIl3cXS7IHH0JGZZWiCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{B2eHKnZ4XsZZRqd25ib3[gV2hRKG2UTlGg[ZhxemW|c3nvckBifCBzMDD1UUBi\nSncjCxPEBpenNiYomgVnQuWEOUIHHuZYx6e2m| MmXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|OEezNlUoRjJ2M{i3N|I2RC:jPh?=
HepG2 MmLDSpVv[3Srb36gZZN{[Xl? MVSxNEB2VQ>? M4jxWlE5KGi{cx?= MXjB[49vcXO2IHHjeIl3cXS7IHH0JGZZWiCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{B2eHKnZ4XsZZRqd25ib3[gRmVUWCCvUl7BJIV5eHKnc4Ppc44h[XRiMUCgeW0h[W[2ZYKgNVghcHK|IHL5JHJVNVCFUjDhcoFtgXOrcx?= M4HEO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{i3N|I2Lz5{NEO4O|MzPTxxYU6=
GLUTag MofaSpVv[3Srb36gZZN{[Xl? NHL5VFRC\2:waYP0JIFkfGm4aYT5JIF1KEeSLVLBVlEhcW5ibX;1d4UhT0yXVHHnJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEeOUD2xJJJmdGWjc3W= NGny[WM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO4O|MzPSd-MkSzPFc{OjV:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
XBP1s; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 6-ECDCA (0-10 μM) or DMSO vehicle for 4 hours. Representative western blot of XBP1s is shown with GAPDH used as a loading control.

p-IRE1α; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 2.5 μM 6-ECDCA or DMSO for 2 hours. Western blotting was performed for phosphorylated-IRE1α (p-IRE1α). Cellular p-IRE1α expression is increased in Huh7-Ntcp cells in response to FXR-agonist treatment.

29377207
In vivo In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. [1] Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. [2] In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension. [3]

Protocol

Animal Research:

[1]

- Collapse
  • Animal Models: Rat cholestasis model
  • Dosages: Saline
  • Administration: Infused at the right jugular vein using PE-50 polyethylene tubing
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (199.7 mM)
Water Insoluble
Ethanol '84 mg/mL warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 420.63
Formula

C26H44O4

CAS No. 459789-99-2
Storage powder
in solvent
Synonyms INT-747, 6-ECDCA
Smiles CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O

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    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What formulation can we use to dissolve Obeticholic Acid (Catalog No.S7660) for mice in vivo study?

  • Answer:

    You can use the vehicle of: 1% wt/vol methyl-cellulose as indicated in this paper, http://www.sciencedirect.com/science/article/pii/S0925443911000883 "daily oral gavage with 5 mg/kg/day INT-747 (6-ethyl-chenodeoxycholic acid, Obeticholic acid, Intercept Pharmaceuticals Inc, New York, NY) or vehicle (1% wt/vol methyl-cellulose) from 3 days prior to induction of colitis"

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