Obeticholic Acid

For research use only.

Catalog No.S7660 Synonyms: INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid

12 publications

Obeticholic Acid Chemical Structure

CAS No. 459789-99-2

Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.

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Selleck's Obeticholic Acid has been cited by 12 publications

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  • (c) Functional bile canaliculi or lack thereof in PHHs within MPTCs (12 d of drug treatment) as visualized by transport of fluorescent (green) dye into the canaliculi between PHHs. DMSO-treated MPCC control image is shown to the far right. (d) Neutral lipid (Nile red, green) staining of PHHs within MPTCs (12 d of drug treatment). DMSO-treated MPCC control image is shown to the far right. (e) NR1I2 (PXR) gene expression in drug-treated MPTCs relative to DMSOtreated MPTC controls (12 d of treatment). (f) ABCC2 (MRP2) gene expression in drug-treated MPTCs relative to DMSO-treated MPTC controls (12 d of treatment). (g) IL-6 levels in drug-treated MPTC supernatants (6 d of treatment). In all panels, statistical significance is displayed relative to DMSO-treated MPTCs. *p r 0.05, **p r 0.01, ***p r 0.001, and ****p r 0.0001. Scale bars on images represent 80 mm.

    Integr Biol (Camb), 2017, 9(8):662-677. Obeticholic Acid purchased from Selleck.

    HuCCT1 cells were treated with OCA (1 μM) and control solvent in the presence and absence of IL-6 (20 ng/mL). EMT-related proteins were examined by western blotting. β-actin was used as a control.

    Cell Physiol Biochem, 2018, 48(1):158-172. Obeticholic Acid purchased from Selleck.

  • (D) Expression of hepatic FXR target genes, n = 3. Data are expressed as mean ± SD, ###P < 0.001 versus group 1, *P < 0.05, **P < 0.01, and ***P b 0.001 versus group 2, sP < 0.05, ssP < 0.01, and sssP < 0.001 versus group 3

    Toxicol Appl Pharmacol, 2017, 315:23-34. Obeticholic Acid purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Obeticholic Acid inhibits autophagy. Phase 3.
Targets
FXR [1]
99 nM(EC50)
In vitro

In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
insect cells NGrSOmtHfW6ldHnvckBie3OjeR?= MnrmNUBpeg>? M2m2UmFod26rc4SgZYN1cX[rdImgZZQhemWlb33ibY5idnRiaIXtZY4hT1OWLYTh[4dm\CCIWGKgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKChzOUOgeI8hPDd{IILld4llfWW|KTDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDpcpRmemGldHnvckB4cXSqIHLpc5RqdiCuYXLlcIxm\CCVUlOtNUBi\nSncjCxJIhzKGK7IFjUVmYh[XO|YYmsJGVEPTBiPTCwMlAyKM7:TT6= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF2OEiwOkc,OjlzNEi4NFY9N2F-
HEK293T M{\OeWZ2dmO2aX;uJIF{e2G7 M1jrUVI1KGi{cx?= MlnjRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDGXHIh\XiycnXzd4VlKGmwIFjFT|I6O1RiY3XscJMh[XO|ZYPz[YQh[XNiQmPFVEBxem:vb4TldkBlemm4ZX6gZ4VtdHWuYYKgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTBiPTCwMlA1OiEQvF2u MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF2OEiwOkc,OjlzNEi4NFY9N2F-
COS1 MYPGeY5kfGmxbjDhd5NigQ>? NUnYNmF6SWexbnnzeEBi[3Srdnn0fUBifCCIWGKg[ZhxemW|c3XkJIlvKEORU{GgZ4VtdHNiYomgZ4VtdC2kYYPl[EBjcW:udX3pcoV{[2WwY3WgZZN{[XluIFXDOVAhRSByLkC5PUDPxE1w M1\zWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEG0PFcxLz5{MECxOFg4ODxxYU6=
HeLa NFvkUVdHfW6ldHnvckBie3OjeR?= MmjDNlQhcHK| NXmwNG57SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBnfWyuIHzlcod1cCCIWGKg[ZhxemW|c3XkJIlvKEinTHGgZ4VtdHNiY3;0doFve2[nY4Tl[EB4cXSqIIDTS|UucHWvYX6gVnhTKGGodHXyJFI1KGi{czDifUBFfWGuLVfsc{BtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVAhRSByLkG2JO69VS5? M{jCWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlI4Lz5{NUmzOFIzPzxxYU6=
HeLa M4DVWGZ2dmO2aX;uJIF{e2G7 MWHB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIF\YVkBmgHC{ZYPz[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDy[YNmeHSxcjDhZ5RqfmG2aX;uJIJ6KEKVRWCgdJJwdW:2ZYKt[JJqfmWwIH\pdoVndHlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNE4yPiEQvF2u M1OxO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkW1NFM6Lz5{NUK1OVA{QTxxYU6=
insect cells NVr6VGxDTnWwY4Tpc44h[XO|YYm= MnXnNUBpeg>? NHPrN5FC\2:waYP0JIFkfGm4aYT5JIF1KHKnY3;tZolv[W62IHj1cYFvKEeVVD30ZYdo\WRiRmjSJGxDTCBqMUmzJJRwKDR5MjDy[ZNq\HWnczmg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|LXnu[oVkfGWmIHnud4VkfCClZXzsd{Bie3Onc4Pl[EBieyC{ZXPyeYl1dWWwdDDv[kBjcW:2aX75cIF1\WRiU2LDNUBx\XC2aXTlJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliQXzwbIF{[3KnZX6gZZN{[XluIFXDOVAhRSByLkG4JO69VS5? NV\vWYpoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmyOVk4PDJpPkK5NlU6PzR{PD;hQi=>
COS1 MVzGeY5kfGmxbjDhd5NigQ>? M{\UUVUhcHK| NEfFOHpC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGZZWiCneIDy[ZN{\WRiaX6gR29UOSClZXzsd{Bi\nSncjC1JIhzeyCkeTDDVmUu\HKrdnXuJIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwM{[xJO69VS5? NIX5ZoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[4OVYxOyd-MUe2PFU3ODN:L3G+
CHO NVHaRZFsTnWwY4Tpc44h[XO|YYm= M{C0XFUhcHK| MXjB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGTHVlUh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczDh[pRmeiB3IHjyd{BjgSCFUlWt[JJqfmWwIHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvPzV3IN88UU4> NVXnO3B4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PFU3ODNpPkG3Olg2PjB|PD;hQi=>
HEK293 M{\mWmZ2dmO2aX;uJIF{e2G7 MmTRNUBpeg>? MnXxRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDUS3I2KGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbY51emGlZXzseYxieiClQV3QJIxmfmWuIHHmeIVzKDFiaIKgZpkhXFJvRmLFWEBie3OjeTygSWM2OCB;IECuPFQh|ryPLh?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ3OUe0Nkc,Ojl{NUm3OFI9N2F-
NCI-H716 NYfLWpNiTnWwY4Tpc44h[XO|YYm= NYS1dHhSSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IILlZ4VxfG:{IHX4dJJme3OnZDDpckBPS0lvSEexOkBk\WyuczDhd5Nme3OnZDDhd{BqdnS{YXPlcIx2dGG{IHPBUXAhdGW4ZXygZpkhXFJvRmLFWEBie3OjeTygSWM2OCB;IEKwJO69VS5? NXX0UYdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVk2QDBpPkKxOFU6PThyPD;hQi=>
HepG2 NH3lTI1HfW6ldHnvckBie3OjeR?= NFK1[VEzOCC3TR?= MVzJcoR2[3Srb36gc4YhTliULX3l[IlifGWmIGPIVEBuWk6DIHX4dJJme3Orb36gbY4hcHWvYX6gTIVxTzJiY3XscJMh[XRiMkCgeW0h[nliUmStVGNT M4LJelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MkLuSpVv[3Srb36gZZN{[Xl? M4Lac|EhfU1? MXfJcoR2[3Srb36gc4YhTliULX3l[IlifGWmIGPIVEBuWk6DIHX4dJJme3Orb36gbY4hcHWvYX6gTIVxTzJiY3XscJMh[XRiMTD1UUBjgSCUVD3QR3I> NV\sSZN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0OVk2QDBpPkKxOFU6PThyPD;hQi=>
HepG2 M4\LUWZ2dmO2aX;uJIF{e2G7 NVPMO3dZOjBidV2= Ml\WTY5lfWO2aX;uJI9nKE[[Uj3t[YRq[XSnZDDCV2VRKG2UTlGg[ZhxemW|c3nvckBqdiCqdX3hckBJ\XCJMjDj[YxteyCjdDCyNEB2VSCkeTDSWE1RS1J? NE\h[2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS1PVU5OCd-MkG0OVk2QDB:L3G+
HepG2 NUjubY14TnWwY4Tpc44h[XO|YYm= NYOwb4RzOjBidV2= NI\rZWhKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJG9{fGKndHGgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDJyIIXNJIJ6KFKWLWDDVi=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3OUW4NEc,OjF2NUm1PFA9N2F-
HepG2 NIP0U21HfW6ldHnvckBie3OjeR?= MYmxJJVO MW\JcoR2[3Srb36gc4YhTliULX3l[IlifGWmIHTve44uemWpdXzheIlwdiCxZjDDfZA4STFibWLORUBmgHC{ZYPzbY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFEhfU1iYomgVnQuWEOU MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTR3OUW4NEc,OjF2NUm1PFA9N2F-
HepG2 MUXGeY5kfGmxbjDhd5NigQ>? MVKyNEB2VQ>? NFLwbFJKdmS3Y4Tpc44hd2ZiRmjSMY1m\GmjdHXkJIRwf25vcnXneYxifGmxbjDv[kBEgXB5QUGgcXJPSSCneIDy[ZN{cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDJyIIXNJIJ6KFKWLWDDVi=> M3nCTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 NEjyN2tHfW6ldHnvckBie3OjeR?= MVyyNEB2VQ>? NEHBXWtC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGZZWiCneIDy[ZN{\WRiaX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXubYxt[SCudXPp[oVz[XOnIHHjeIl3cXS7IHH0JFIxKHWPIHL5JIx2[2moZYLhd4Uh[mG|ZXSgeJJidnOjY4TpeoF1cW:wIHHzd4F6 M2rJd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 MXnGeY5kfGmxbjDhd5NigQ>? MoDCNUB2VQ>? MULJcoR2[3Srb36gc4YhTliULX3l[IlifGWmIFLTSXAhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGG2IEGgeW0h[nliUmStVGNT MlX3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2NUm1PFAoRjJzNEW5OVgxRC:jPh?=
HepG2 NWD1VY5XTnWwY4Tpc44h[XO|YYm= M13uZlEhfU1? M3r2bGlv\HWldHnvckBw\iCIWGKtcYVlcWG2ZXSgU5N1[mW2YTDtVm5CKGW6cILld5Nqd25iaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOSC3TTDifUBTXC2SQ2K= M3zVPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEW5OVgxLz5{MUS1PVU5ODxxYU6=
HepG2 M3TyWWZ2dmO2aX;uJIF{e2G7 NVL5Spl5OTBidV2= M3jnbXRz[W6|YXP0bZZifGmxbjDv[kBpfW2jbjDGXHIhfHKjboPm[YN1\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZQhOTBidV2gZpkh[mW2YT3nZYxi[3Sxc3nkZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 MnTKSpVv[3Srb36gZZN{[Xl? MWKxNEB2VQ>? M2jJU|E5KGi{cx?= M{TEV2Fod26rc4SgZYN1cX[rdImgZZQhTliUIHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBQW1RvYXzwbIEhdVKQQTDlfJBz\XO|aX;uJIF1KDFyIIXNJIFnfGW{IEG4JIhzeyCkeTDSWE1RS1JiYX7hcJl{cXN? NFPiO2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO4O|MzPSd-MkSzPFc{OjV:L3G+
GLUTag M3fDPGZ2dmO2aX;uJIF{e2G7 NVnReZplSWexbnnzeEBi[3Srdnn0fUBifCCJUD3CRXIyKGmwIH3veZNmKEeOVWTh[{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJINCVVBibHX2[Yw> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 MXjGeY5kfGmxbjDhd5NigQ>? M4XTWVExKHWP NIO1co8yQCCqcoO= NF;2NVNC\2:waYP0JIFkfGm4aYT5JIF1KE[[UjDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YhW0iSIH3SUmEh\XiycnXzd4lwdiCjdDCxNEB2VSCjZoTldkAyQCCqcoOgZpkhWlRvUFPSJIFv[Wy7c3nz MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN6N{OyOUc,OjR|OEezNlU9N2F-
HepG2 NGHMbZNHfW6ldHnvckBie3OjeR?= NXLUeWN4OTBidV2= M{S1dVE5KGi{cx?= MorXRYdwdmm|dDDhZ5Rqfmm2eTDheEBHYFJiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJGJGW1BibWLORUBmgHC{ZYPzbY9vKGG2IEGwJJVOKGGodHXyJFE5KGi{czDifUBTXC2SQ2KgZY5idHm|aYO= NUW1ZZZWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzPFc{OjVpPkK0N|g4OzJ3PD;hQi=>
GLUTag MYTGeY5kfGmxbjDhd5NigQ>? Mn\rRYdwdmm|dDDhZ5Rqfmm2eTDheEBIWC2EQWKxJIlvKG2xdYPlJGdNXVSjZzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBIVFBvMTDy[Yxm[XOn Mly2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|OEezNlUoRjJ2M{i3N|I2RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
XBP1s; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 6-ECDCA (0-10 μM) or DMSO vehicle for 4 hours. Representative western blot of XBP1s is shown with GAPDH used as a loading control.

p-IRE1α; 

PubMed: 29377207     


Huh7-Ntcp cells were treated with 2.5 μM 6-ECDCA or DMSO for 2 hours. Western blotting was performed for phosphorylated-IRE1α (p-IRE1α). Cellular p-IRE1α expression is increased in Huh7-Ntcp cells in response to FXR-agonist treatment.

29377207
In vivo In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. [1] Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. [2] In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension. [3]

Protocol

Animal Research:

[1]

- Collapse
  • Animal Models: Rat cholestasis model
  • Dosages: Saline
  • Administration: Infused at the right jugular vein using PE-50 polyethylene tubing
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (199.7 mM)
Water Insoluble
Ethanol ''84 mg/mL warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 420.63
Formula

C26H44O4

CAS No. 459789-99-2
Storage powder
in solvent
Synonyms INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid
Smiles CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O

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    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What formulation can we use to dissolve Obeticholic Acid (Catalog No.S7660) for mice in vivo study?

  • Answer:

    You can use the vehicle of: 1% wt/vol methyl-cellulose as indicated in this paper, http://www.sciencedirect.com/science/article/pii/S0925443911000883 "daily oral gavage with 5 mg/kg/day INT-747 (6-ethyl-chenodeoxycholic acid, Obeticholic acid, Intercept Pharmaceuticals Inc, New York, NY) or vehicle (1% wt/vol methyl-cellulose) from 3 days prior to induction of colitis"

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