Dexamethasone Sodium Phosphate

Catalog No.S4028 Synonyms: Dexamethasone 21-phosphate disodium salt

For research use only.

Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Dexamethasone Sodium Phosphate Chemical Structure

CAS No. 55203-24-2

Selleck's Dexamethasone Sodium Phosphate has been cited by 27 publications

Purity & Quality Control

Choose Selective IL Receptor Inhibitors

Other IL Receptor Products

Biological Activity

Description Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Features Great selectivity for COX-2.
Targets
IL receptor [6] COX-2 [1]
In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mice spleen cells NE\GW|VHfW6ldHnvckBie3OjeR?= MYXJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCWIHPlcIwheHKxbHnm[ZJifGmxbjD1d4lv\yClb37jZY5ifmGuaX6gRUB{fGmvdXzheIVlKG2rY3Wgd5Bt\WWwIHPlcIx{NCCLQ{WwQVAvODB3zszN M{nLNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMkK5O|Y4Lz5zMUKyPVc3PzxxYU6=
PBMC M3L5[mZ2dmO2aX;uJIF{e2G7 M1XjSmlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IGTOSk1idHCqYTDwdo9lfWO2aX;uJIZzd21iaIXtZY4heGW{aYDo[ZJidCCkbH;v[EBud26xboXjcIVieiClZXzsd{B{fGmvdXzheIVlKGK7IFzQV{whUUN3ME2wMlAy|ryP M4P2VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMkK5O|Y4Lz5zMUKyPVc3PzxxYU6=
PBMC MULGeY5kfGmxbjDhd5NigQ>? MofYTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiZ4Lve5RpKG:oIFzQV{B{fGmvdXzheIVlKGi3bXHuJJBmemmyaHXyZYwh[myxb3SgcY9vd263Y3zlZZIh[2WubIOsJGlEPTB;MD6wOO69VQ>? M{myT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzMkK5O|Y4Lz5zMUKyPVc3PzxxYU6=
RAW264.7 NVSwXGY3SW62aXnu[oxidW2jdH;yfUBie3OjeR?= MoHoNlQhcHK| MmPpRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBNWFNvc4TpcZVt[XSnZDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCnZn\lZ5Qhd25iVF7GZYxxcGFiZn;ycYF1cW:wIIDy[ZRz\WG2ZXSgNUBpeiCkZX\vdoUhVFCVIHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB{NDDodpMtKEmFNUC9NE44|ryP NYC1cZlJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG5NFg6QDRpPkGxPVA5QTh2PD;hQi=>
N9 M1;1[mZ2dmO2aX;uJIF{e2G7 MXTJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgWG5HNWGucHjhJJJmdGWjc3WgbY4hVjliY3XscJMhcW5idHjlJJN2eGW{bnH0ZY51NCCLQ{WwQVAvODd2zszN NYnjWWpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKzOlE{QTVpPkGyN|YyOzl3PD;hQi=>
RAW 264.7 M3;FTmZ2dmO2aX;uJIF{e2G7 Ml7rTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JHRPTi2jbIDoZUBz\WynYYPlJIlvKFKDVzCyOlQvPyClZXzsd{BqdiC2aHWgd5Vx\XKwYYThcpQtKEmFNUC9NE41Os7:TR?= NGrPOnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkO2NVM6PSd-MUKzOlE{QTV:L3G+
A549 NXS2SVRJTnWwY4Tpc44h[XO|YYm= MmPSNVAhfU1? M2XiOGFvfGGpb37pd5Qh[WO2aY\peJkh\m:{IFfseYNw[2:{dHnjc4llKHKnY3XweI9zKGmwIF3NWHYhfHKjboPhZ5RqfmG2aX;uJIF{e2G7IHnuJIh2dWGwIFG1OFkhdHWwZzDldIl1cGWuaXHsJINmdGy|IHH0JFExKHWPLDDJR|UxRDFyzszN NEHpOFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUm5PVk5QSd-MUW5PVk6QDl:L3G+
A549 NVPSRZltTnWwY4Tpc44h[XO|YYm= M33kUmFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIFfSSUBxem:vb4TldkBz\XOyb37z[UBjgSCudXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCHQ{WwQVAvODBzzszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ2M{C2NEc,OTZ4NEOwOlA9N2F-
A549 MVzGeY5kfGmxbjDhd5NigQ>? NHnBSJZC\2:waYP0JIFkfGm4aYT5JIF1KEeUIHHzd4V{e2WmIHHzJG5HNWujcIDhRk1u\WSrYYTl[EB1emGwc4LldJJme3Orb36gc4Yhe2WlcnX0[YQheGyjY3XueIFtKGGua3HsbY5mKHCqb4PwbIF1[XOnIHflcoUhcW5iaIXtZY4hSTV2OTDj[YxteyxiSVO1NF0xNjByMUG3Oe69VQ>? NXq4XnF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[4NlE4QDFpPkG2PFIyPzhzPD;hQi=>
A549 MYXGeY5kfGmxbjDhd5NigQ>? NXTCb|BxSWexbnnzeEBi[3Srdnn0fUBifCCJUjDhd5Nme3OnZDDhd{BOVVSYLX3l[IlifGWmIITyZY5{[WO2aY\heIlwdiCxZjDy[Y5qdGyjIHz1Z4ln\XKjc3Wg[4Vv\SCrbjDoeY1idiCDNUS5JINmdGy|IILlcIF1cX[nIITvJGRmgGGvZYToZZNwdmVuIFXDOVA:OC5yMEWwNVLPxE1? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjh{MUe4NUc,OTZ6MkG3PFE9N2F-
HFF MnqzSpVv[3Srb36gZZN{[Xl? NXu5VVJpUW6qaXLpeIlwdiCxZjDJUFEue3SrbYXsZZRm\CCLTE[gdJJw\HWldHnvckBqdiCKRl[gZ4VtdHNuIFnDOVA:OC5yMEC1Ne69VQ>? Mn7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxO|IoRjF5MUixNVczRC:jPh?=
HFF NWeySJpGTnWwY4Tpc44h[XO|YYm= MXTJcoR2[3Srb36gc4Yh[XKxbXH0ZZNmKGGldHn2bZR6KGmwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{Bxem:mdXP0bY9vKG:oIHLleIEh\XO2cnHkbY9tKGK7IHHyc41ifGG|ZTDhd5NigSxiRVO1NF0xNjByMUpOwG0> MoHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxO|IoRjF5MUixNVczRC:jPh?=
HeLa MnLESpVv[3Srb36gZZN{[Xl? NGX6NoRC[3SrdnH0bY9vKG:oIF3NWHYhcW5iSHXMZUBk\WyuczDt[YF{fXKnZDDifUBtfWOrZnXyZZNmKGGldHn2bZR6NCCHQ{WwQVAvODF5zszN NVrFVVVFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPzJpPkG3NVgyOTd{PD;hQi=>
RAW 264.7 M1LTUGZ2dmO2aX;uJIF{e2G7 M3;FUlI1KGi{cx?= Mn3LTY5pcWKrdHnvckBw\iCrboTldoZmem:wIHfhcY1iNXO2aX31cIF1\WRiTl:gdJJw\HWldHnvckBqdiCUQWegNlY1NjdiY3XscJMh[W[2ZYKgNlQhcHK|LDDJR|UxRTBwMENOwG0> NYDV[FRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOlcyOjRpPkG3N|Y4OTJ2PD;hQi=>
RAW264.7 NYSzN2Z1TnWwY4Tpc44h[XO|YYm= NHTJUWMzKGi{cx?= NWrjPGxpUW6qaXLpeIlwdiCxZjDtVGdGWzFiZYjwdoV{e2mxbjDpckBNWFNvc4TpcZVt[XSnZDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bi\nSncjCyJIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> NHfIPYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SwO|I4Pyd-MUe0NFczPzd:L3G+
RAW264.7 M3\nSmZ2dmO2aX;uJIF{e2G7 NXm5U4JlOiCqcoO= MmWxTY5pcWKrdHnvckBw\iCFT2iyJIV5eHKnc4Ppc44hcW5iTGDTMZN1cW23bHH0[YQhdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYX\0[ZIhOiCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NGHvPXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SwO|I4Pyd-MUe0NFczPzd:L3G+
A549 NVrhWJRPTnWwY4Tpc44h[XO|YYm= NXXQVHRxSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBCPTR7IHPlcIx{KGK7IF7GMYtieHCjQjD0doFve3KncILld5Nqd25iYYPzZZktKEmFNUC9NE4xODIQvF2= NXfPeZFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2NVY{QTVpPkG3OlE3Ozl3PD;hQi=>
A549 NEf6cWhHfW6ldHnvckBie3OjeR?= MoK0RYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE2PVG[geJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvODB3M{hOwG0> NF\hZnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[xOlM6PSd-MUe2NVY{QTV:L3G+
A549 NF;FUXpHfW6ldHnvckBie3OjeR?= Mm\2RY51[WexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBCPTR7IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghVU2WVjDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCmZYjhcYV1cGG|b37lMYlv\HWlZXSgZYN1cX[jdHnvckwhUUN3MEyx{txO MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZzNkO5OUc,OTd4MU[zPVU9N2F-
HFF MVTBcpRqcW6obHHtcYF1d3K7IHHzd4F6 M4fFV2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUFEhe3SrbYXsZZRm\CCLTE[gdJJw\HWldHnvckBqdiCKRl[gZ4VtdHNiYomgeJJidnO{ZYDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVAvODByNd88US=> NF7CSpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5NlUyQSd-MUe2PVI2OTl:L3G+
HFF NHvYfmJCdnSraX7mcIFudWG2b4L5JIF{e2G7 MofwRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{B2eHKnZ4XsZZRqd25ib3[gZZJwdWG2YYPlJIlvKEiIRjDj[YxteyCkeTD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4xODMQvF2= NETNd|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5NlUyQSd-MUe2PVI2OTl:L3G+
CV1 NULpfYZYTnWwY4Tpc44h[XO|YYm= NVjKUYk2SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBIWiCneIDy[ZN{\WRiaX6gR3YyKGOnbHzzJIJ6KEeURTDhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMECwNu69VQ>? M4nZfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C1N|YzLz5zN{ewOVM3OjxxYU6=
NHDFneo MmPYSpVv[3Srb36gZZN{[Xl? M36xeWFkfGm4aYT5JIF1KGi3bXHuJGdTKGW6cILld5Nm\CCrbjDOTGRHdmWxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhUUxvNjDwdo9lfWO2aX;uMEBKSzVyPUCuNFAyPM7:TR?= M4\CWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{C1N|YzLz5zN{ewOVM3OjxxYU6=
RPMI8226 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MXy0JIRigXN? NWLhe3NySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDSVG1KQDJ{NjDj[YxteyCjZoTldkA1KGSjeYOsJGlEPTB;MD6wNFY2|ryP MkfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEWzOlIoRjF5N{C1N|YzRC:jPh?=
J774A.1 MofWSpVv[3Srb36gZZN{[Xl? MYDJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSoFteGijIIDyc4R2[3Srb36gbY4hdW:3c3WgTlc4PEFwMTDj[YxteyxiSVO1NF0xNjB2ON88US=> M3\CN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEmyPVQyLz5zN{i5Nlk1OTxxYU6=
CV1 NH;TUJhHfW6ldHnvckBie3OjeR?= Mn\PRYN1cX[rdImgZZQhcHWvYX6g[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNXOSClZXzsd{Bie3Onc4Pl[EBieyC{ZYDy[ZN{cW:wIH;mJHRPTiCjbnSgTWwuOS2kZYThMYlv\HWlZXSgSU1{\WynY4TpckBo\W6nIHX4dJJme3Orb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFSFUxRTBwMECwNe69VQ>? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB|Mk[xNEc,OThyM{K2NVA9N2F-
A549 Ml3wSpVv[3Srb36gZZN{[Xl? MnHzRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDBOVQ6KGOnbHzzJIJ6KE6ILXvhdJBiSiC2cnHud5JmeHKnc4Ppc44h[XO|YYmsJGlEPTB;MD6wNFEyPzYQvF2= NGixOW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOECzPFk4OCd-MUiwN|g6PzB:L3G+
A549 MnPWSpVv[3Srb36gZZN{[Xl? NIjnSmdC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[nliTV3UWkB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5yMEWwNVLPxE1? M13iSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEO4PVcxLz5zOECzPFk4ODxxYU6=
COS7 NH3JXXBHfW6ldHnvckBie3OjeR?= NGfjUm8yKHWP M{CxUWFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgVVU4OEFibYX0ZY51KGmwIFPPV|ch[2WubIOgZZQhOSC3TTDifUBPTi2tYYDwZWIudHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 MmTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyM{i5O|AoRjF6MEO4PVcxRC:jPh?=
HeLa MojRR5l1d3SxeHnjbZR6KGG|c3H5 MmTsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGRPSSC{ZYDsbYNifGmxbjDifUBqdWGpaX7nJIFv[Wy7c3nz Ml\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyNk[wOVUoRjF6ME[2NFU2RC:jPh?=
HeLa M3GxOmZ2dmO2aX;uJIF{e2G7 M4PnWGlvcGmkaYTpc44hd2ZibXn0c5NqeyCrbjDoeY1idiCKZVzhJINmdGy|IHL5JIlu[WerbnegZY5idHm|aYO= MmS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyNk[wOVUoRjF6ME[2NFU2RC:jPh?=
R1 NV3TbFhZTnWwY4Tpc44h[XO|YYm= NH;WUngyOCC3TR?= NEO3WVEzPCCqcoO= NYOyVYprUW6qaXLpeIlwdiCxZjDncJVkd2OxcoTpZ49q\CC{ZXPldJRwei2pbIXjc4NwenSrY3;p[EBkd22ybHX4JJRz[W6|ZnXjeIVlKGmwIILheEBTOSClZXzsd{Bie3Onc4Pl[EBieyCmb4fuMZJm\3WuYYTpc44hd2ZiVGDBMZJme3CxboPpeoUh\WynbXXueEBxem:rbn\sZY1u[XSxcomg[4Vv\SCneIDy[ZN{cW:wIHH0JFExKHWPIHHmeIVzKDJ2IHjyd{BjgSCkZYThMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9NE4xODYQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzMkO5O{c,OTh2MUKzPVc9N2F-
THP1 M{fKXmFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? MVrBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVDZiYomgSWxKW0FuIFnDOVA:OC5yMEhOwG0> MmrhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4MkW1OlAoRjF6NkK1OVYxRC:jPh?=
THP1 MYnBcpRqcW6obHHtcYF1d3K7IHHzd4F6 MlPHRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhXE6IYXzwbIEh[nliRVzJV2EtKEmFNUC9NE4xPc7:TR?= MljtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4MkW1OlAoRjF6NkK1OVYxRC:jPh?=
RAW264.7 NX;5cmJKTnWwY4Tpc44h[XO|YYm= MVKxNEB2VQ>? NVfIcVhtUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCFT2iyJIV5eHKnc4Ppc44hcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZQhOTBidV2gZpkhX2W|dHXyckBjdG:2 M3TNO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{mwOlQ6Lz5zOEe5NFY1QTxxYU6=
RAW264.7 NUjjOHZ6TnWwY4Tpc44h[XO|YYm= MlvZTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBucWO{b4PvcYFtKHC{b4P0ZYdt[W6maX6gSUB{gW62aHHz[UAyKGW6cILld5Nqd25iYYSgNVAhfU1iaX6gcY92e2ViUlHXNlY1NjdiY3XscJMh[nliV3XzeIVzdiCkbH;0 NV\0TmhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3PVA3PDlpPkG4O|kxPjR7PD;hQi=>
A549 MUPGeY5kfGmxbjDhd5NigQ>? Ml\TWJJidnO{ZYDy[ZN{cW:wIHHjeIl3cXS7IHH0JGdTKGmwIFnMMVEu[mW2YT3zeIlufWyjdHXkJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDOSk1s[XCyYVKt[IVx\W6mZX70JGUue2WuZXP0bY4hfHKjboPjdolxfGmxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMEGx{txO MnW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MkGzOFEoRjF7M{KxN|QyRC:jPh?=
A549 M1rydGZ2dmO2aX;uJIF{e2G7 NI[5d|RVemGwc4LldJJme3Orb36gZYN1cX[rdImgZZQhT1JiaX6gVG1CNXO2aX31cIF1\WRiaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGSMTDy[ZNxd26|ZTDlcIVu\W62LXnu[JVk\WRibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGGldHn2bZR6NCCHQ{WwQVAvODB{Nd88US=> NHfxZZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOyNVM1OSd-MUmzNlE{PDF:L3G+
NP1 NGTpeG5HfW6ldHnvckBie3OjeR?= NYj1Rm82SWexbnnzeEBi[3Srdnn0fUBifCCJUjDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHj1cYFvKE6SMTDj[YxteyCjc4Pld5Nm\CCjczDncJVkd2OxcoTpZ49q\CC{ZYPwc45{\SCnbHXt[Y51KHS{YX7zZYN1cX[jdHnvckBjgSCJQVy0JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjByNENOwG0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN{MUO0NUc,OTl|MkGzOFE9N2F-
TH2 M3XncmZ2dmO2aX;uJIF{e2G7 MkDnOFghcHK| MVvJcohq[mm2aX;uJI9nKHC{bz3pcoZt[W2vYYTvdpkh[3m2b3vpcoUhUUx3IIDyc4R2[3Srb36gbY4hd3[jbHL1cYlvNXO2aX31cIF1\WRiQlHMRk9kKG2xdYPlJHRJOiClZXzsd{Bi\nSncjC0PEBpenNiYomgd4Fv\HerY3itSWxKW0FuIFnDOVA:OC5yMEZOwG0> M1TUWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{KzOFg{Lz5zOUOyN|Q5OzxxYU6=
TH2 NHTo[XlHfW6ldHnvckBie3OjeR?= NGrRR4I1QCCqcoO= M4LseWlvcGmkaYTpc44hd2ZicILvMYlv\myjbX3heI9zgSCleYTvb4lv\SCLTEGzJJBzd2S3Y4Tpc44hcW5ib4\hcIJ2dWmwLYP0bY12dGG2ZXSgRmFNSi:lIH3veZNmKFSKMjDj[YxteyCjZoTldkA1QCCqcoOgZpkhe2GwZIfpZ4guTUyLU1GsJGlEPTB;MD6wNFXPxE1? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN{M{S4N{c,OTl|MkO0PFM9N2F-
MDA-kb2 MXPGeY5kfGmxbjDhd5NigQ>? M{[0O2Fod26rc4SgZYN1cX[rdImgZZQh[W6mcn;n[Y4hemWlZYD0c5IhcW5iaIXtZY4hVUSDLXviNkBk\WyuczDhd5Nme3OnZDDhd{B{fGmvdXzheIlwdiCxZjDseYNq\mW{YYPlJIFkfGm4aYT5JIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWMyPTB;MD6xPVTPxE1? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7MkK0OUc,OTl3OUKyOFU9N2F-
MDA-kb2 NUC5d21sTnWwY4Tpc44h[XO|YYm= MVrB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1s[jJiY3XscJMh[XO|ZYPz[YQh[XNic4TpcZVt[XSrb36gc4YhdHWlaX\ldoF{\SCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFMUWwQVAvOTl2zszN MnjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OUKyOFUoRjF7NUmyNlQ2RC:jPh?=
A549 MlzvSpVv[3Srb36gZZN{[Xl? MV3B[49vcXO2IHHjeIl3cXS7IHH0JGdTKGmwIHj1cYFvKEF3NEmgZ4VtdHNiYomgUmYuc2GycHHCJJRz[W6|cnXwdoV{e2mxbjDhd5NigSxiSVO1NF0xNjByMd88US=> MljkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OUKyOFcoRjF7NUmyNlQ4RC:jPh?=
COS7 NV76O4pLTnWwY4Tpc44h[XO|YYm= M{PlVGFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1NSkRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODB5Mt88US=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh4M{C4N{c,OTl6NkOwPFM9N2F-
A549 M{O3[mZ2dmO2aX;uJIF{e2G7 NEPReHk3KGi{cx?= MVTUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUE0yNWKndHGtbY5lfWOnZDDOSk1s[XCyYVKg[IVx\W6mZX70JGUue2WuZXP0bY9vKHC{b33veIVzKGGldHn2ZZRqd25iYX\0[ZIhPiCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIJie2WmIFXMRW0h[XO|YYmsJGVEPTB;MD6wNFEy|ryP MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODB2N{K4NEc,OjByNEeyPFA9N2F-
A549 NWfXW2NETnWwY4Tpc44h[XO|YYm= NG\ZNmU3KGi{cx?= NYXxb5ZqXHKjboPy[ZBz\XO|aX;uJIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWE2DLXnu[JVk\WRiQWCxJIFkfGm4aYT5JIFnfGW{IE[gbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAxOjYQvF2= M4TqfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMES3NlgxLz5{MEC0O|I5ODxxYU6=
HeLa NVSzR3pbTnWwY4Tpc44h[XO|YYm= MnPNWJJidnOjY4TpeoF1cW:wIH;mJGdCVC12IITh[4dm\CCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhVlBzIHHjeIl3[XSrb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwMEC0Oe69VQ>? M3LrZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMES3NlgxLz5{MEC0O|I5ODxxYU6=
inflammatory cells NUTOcHl1SW62aXnu[oxidW2jdH;yfUBie3OjeR?= NHO3SZUzKG2pL3vn NVrae5F2SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBEU0yIMT3lcIVkfHKxcH;yZZRm\CC2cnHud4Zm[3SnZDDtc5V{\SCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBqdm[rbITyZZRqd25ib3[gbY5ndGGvbXH0c5J6KGOnbHzzJIF1KDJibXevb4ctKHCx NEezPIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEC5PVgzPyd-MkCwPVk5Ojd:L3G+
NIH-3T3 NV\ZXpluTnWwY4Tpc44h[XO|YYm= NH75XZcxNjBzIH3nM4to MVixJIhz M1PnT2Zz[WO2aX;uJJVv[m:3bnSgbY4hdW:3c3WgdIxie22jIHLlZZJqdmdibX;1d4UhVkmKLUPUN{Bk\WyuczDpcpRm\3KjdHXkJJdqfGhiTV3UWkBz\XCxcoTldkBo\W6nIHH0JFAvODFibXevb4ctKHCxIHHmeIVzKDFiaIKsJGZ2RTBwMECyNFPPxE1? M{L0OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNE[5PFY5Lz5{MES2PVg3QDxxYU6=
NIH-3T3 MoDqSpVv[3Srb36gZZN{[Xl? M{\RbFAvOSCvZz;r[y=> MnPjNUBpeg>? NWLM[oU6TnKjY4Tpc44hfW6kb4Xu[EBqdiCvb4Xz[UBxdGG|bXGgZoViemmwZzDtc5V{\SCQSVitN3Q{KGOnbHzzJIlvfGWpcnH0[YQhf2m2aDDNUXRXKHKncH;yeIVzKGenbnWgZZQhOC5zIH3nM4toNCCybzDh[pRmeiBzIHjyMEBHfT1yLkCxNVbPxE1? NX\ZSHNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0Olk5PjhpPkKwOFY6QDZ6PD;hQi=>
NIH-3T3 NWLUUmxUTnWwY4Tpc44h[XO|YYm= MnnNNE4xOSCvZz;r[y=> NGq1XW0yKGi{ MUfQcIF{dWFiY3;uZ4VvfHKjdHnvckBqdiCvb4Xz[UBj\WG{aX7nJI1wfXOnIF7JTE0{XDNiY3XscJMhcW62ZXfyZZRm\CC5aYToJG1OXFZicnXwc5J1\XJiZ3Xu[UBifCByLkCxJI1oN2upLDDwc{Bi\nSncjCxJIhzNCCFcE2wMlA1PM7:TR?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR4OUi2PEc,OjB2Nkm4Olg9N2F-
NIH-3T3 NGrnVXRHfW6ldHnvckBie3OjeR?= NYjiS5ZCOSCvZz;r[y=> NHPL[WcyKGi{ MYjGdoFkfGmxbjD1coJwfW6mIHnuJI1wfXOnIIDsZZNu[SCkZXHybY5oKG2xdYPlJG5KUC1|VEOgZ4VtdHNiaX70[Ydz[XSnZDD3bZRpKE2PVG[gdoVxd3K2ZYKg[4Vv\SCjdDCxJI1oN2upLDDwc{Bi\nSncjCxJIhzNCCIdU2wMlA5P87:TR?= M3TzVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNE[5PFY5Lz5{MES2PVg3QDxxYU6=
NIH-3T3 NF3F[HhHfW6ldHnvckBie3OjeR?= NH6wNWMxNjFibXevb4c> M4TnPVEhcHJ? NHrzdWxRdGG|bXGgZ49v[2WwdILheIlwdiCrbjDtc5V{\SCkZXHybY5oKG2xdYPlJG5KUC1|VEOgZ4VtdHNiaX70[Ydz[XSnZDD3bZRpKE2PVG[gdoVxd3K2ZYKg[4Vv\SCjdDCwMlEhdWdxa3esJJBwKGGodHXyJFEhcHJuIFPwQVAvOjN4zszN MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODR4OUi2PEc,OjB2Nkm4Olg9N2F-
NIH-3T3 NHW1N2FHfW6ldHnvckBie3OjeR?= MVuxJI1oN2up NGrxW3YyKGi{ NIr6TFFRdGG|bXGgZ49v[2WwdILheIlwdiCrbjDtc5V{\SCkZXHybY5oKG2xdYPlJG5KUC1|VEOgZ4VtdHNiaX70[Ydz[XSnZDD3bZRpKE2PVG[gdoVxd3K2ZYKg[4Vv\SCjdDCxJI1oN2upLDDwc{Bi\nSncjCxJIhzNCCFcE2xMljPxE1? NH;0OYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES2PVg3QCd-MkC0Olk5Pjh:L3G+
NIH-3T3 NGHuOnpHfW6ldHnvckBie3OjeR?= NGG3R3UyOCCvZz;r[y=> MljuNUBpeg>? MX\GdoFkfGmxbjD1coJwfW6mIHnuJI1wfXOnIIDsZZNu[SCkZXHybY5oKG2xdYPlJG5KUC1|VEOgZ4VtdHNiaX70[Ydz[XSnZDD3bZRpKE2PVG[gdoVxd3K2ZYKg[4Vv\SCjdDCxNEBu\y:tZzygdI8h[W[2ZYKgNUBpeixiRoW9OU4yOjQQvF2= NEn2NpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES2PVg3QCd-MkC0Olk5Pjh:L3G+
NIH-3T3 M1fJc2Z2dmO2aX;uJIF{e2G7 NHjFVXAyOCCvZz;r[y=> NIn3OHMyKGi{ MnniVIxie22jIHPvcoNmdnS{YYTpc44hcW5ibX;1d4Uh[mWjcnnu[{Bud3W|ZTDOTWguO1R|IHPlcIx{KGmwdHXndoF1\WRid3n0bEBOVVSYIILldI9zfGW{IHflcoUh[XRiMUCgcYcwc2duIIDvJIFnfGW{IEGgbJItKEOyPUG3MlfPxE1? NGHZSnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES2PVg3QCd-MkC0Olk5Pjh:L3G+
HeLa MV;GeY5kfGmxbjDhd5NigQ>? MVLUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgZ49tdGGpZX7hd4UheHKxbX;0[ZIh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNFAyPTh3zszN MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd{N{e0N{c,OjB5Mke3OFM9N2F-
THP1 M{T5emZ2dmO2aX;uJIF{e2G7 M4L6T3Rz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVC16IIDyc4R2[3Srb36sJGlEPTB;MD6wNFI2OTMQvF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd{N{e0N{c,OjB5Mke3OFM9N2F-
HeLa NVzySo9FTnWwY4Tpc44h[XO|YYm= M{fCVnRz[W6|YXP0bZZifGmxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDNUXRXKHC{b33veIVzKGGldHn2bZR6KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAxPzl2M988US=> MlfZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5Mke3OFMoRjJyN{K3O|Q{RC:jPh?=
Sf9 MkfYSpVv[3Srb36gZZN{[Xl? MlrFRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU3[5JINmdGy|LDDJR|UxRTBwMEGyOVnPxE1? NH7DOVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEeyO|c1Oyd-MkC3Nlc4PDN:L3G+
insect cells M1ztRWZ2dmO2aX;uJIF{e2G7 NVzGUYVlSmmwZHnu[{Bi\m[rbnn0fUB1dyCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOtbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KHW|aX7nJJRmfHKjbXX0bJltemixZHHtbY5mKGyjYnXs[YQhTGW6YX3leIhie2:wZTDifUBndHWxcnXzZ4Vv[2VicH;sZZJqgmG2aX;uJI1q[3KxcHzheIUh[XO|YYmsJGlEPTB;MD6wNFM1|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|NUCwNUc,OjB5M{WwNFE9N2F-
insect cells M1zNXGZ2dmO2aX;uJIF{e2G7 M{\aWGJqdmSrbnegZYZncW6rdImgeI8hdWmwZYLhcI9kd3K2aXPvbYQhemWlZYD0c5Ih\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzMYlv\mWldHXkJIlve2WldDDj[YxteyC3c3nu[{B1\XS{YX3leIh6dHKqb3ThcYlv\SCuYXLlcIVlKESneHHt[ZRp[XOxbnWgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBucWO{b4DsZZRmKGG|c3H5MEBKSzVyPUCuNFM{|ryP M3u0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{O1NFAyLz5{MEezOVAxOTxxYU6=
U2OS NGfZfGtHfW6ldHnvckBie3OjeR?= MmHhNVghcHK| MlfrRY51[WexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1NSkRiaX6gbJVu[W5iVULPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFfhcFQuTEKGIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidILhcpNi[3SrdnH0bY9vKGGldHn2bZR6KGGodHXyJFE5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5yMEC1NFgz|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzMk[4NUc,OjB6MUK2PFE9N2F-
U2OS M1juWGZ2dmO2aX;uJIF{e2G7 Mo[3NVghcHK| NH;xS3RC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yMWxDTCCrbjDoeY1idiCXMl;TJINmdGy|IITyZY5{\mWldHXkJJdqfGhiR3HsOE1FSkRiYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhfHKjboPhZ5RqfmG2aX;uJIFkfGm4aYT5JIFnfGW{IEG4JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC8NVUvQDR6Od88US=> Ml7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUK2PFEoRjJyOEGyOlgyRC:jPh?=
HepG2 NVjIVnZzTnWwY4Tpc44h[XO|YYm= MlX6NlQhcHK| M3PrXGFkfGm4YYTpc44hd2ZicnH0JHBZWiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EBtfW2rbnXzZ4VvfCCjbnHsfZNqeyxiRVO1NF0zNjcQvF2= M3\LfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOU[2NFQ{Lz5{MEm2OlA1OzxxYU6=
A549 MmTESpVv[3Srb36gZZN{[Xl? NGfIOlZVemGwc4LldJJme3Orb36gZYN1cX[rdImgc4Yh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNOWKndHGtd5RqdXWuYYTl[EBPTmujcIDhRk1l\XCnbnTlcpQhTS2|ZXzlZ5RqdiC2cnHud4NzcXC2aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkCwNVHPxE1? NGH0c3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC3N|E6OCd-MkGwO|MyQTB:L3G+
A549 NIXtbnJHfW6ldHnvckBie3OjeR?= NVyyeIVkXHKjboPy[ZBz\XO|aX;uJIFkfGm4aYT5JI9nKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh\XiycnXzd4lv\yCDUD2xJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVG1CNWmwZIXj[YQhSVBvMTDhZ5Rqfmm2eTDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMEK1{txO M{XjbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEezNVkxLz5{MUC3N|E6ODxxYU6=
Hela M2X2eGZ2dmO2aX;uJIF{e2G7 MXPUdoFve2GldHn2ZZRqd25iYXP0bZZqfHlib3[g[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JibHnnZY5lKGKrbnTpcoch\G:vYXnuJIV5eHKnc4Pl[EBqdiCqdX3hckBPWC1zIFjlcIEh[2WubIOgZ48u\XiycnXzd4lv\yCJQVy0JGRPSSCkaX7kbY5oKGSxbXHpckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wNFQz|ryP NULGbGlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwO|MyQTBpPkKxNFc{OTlyPD;hQi=>
13D3/Huh7 MXHGeY5kfGmxbjDhd5NigQ>? NXGyPHdzOjRiaILz MoX3WJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIEGzSFMwUHWqNzDj[YxteyCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhfHm{b4PpcoUh[W2rbn;0doFve2[ncnHz[UBi[3Srdnn0fUBi\nSncjCyOEBpenNuIFXDOVA:OC5yMEZOwG0> MmLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyN{OxPVAoRjJzMEezNVkxRC:jPh?=
A549 NX7KUWR4TnWwY4Tpc44h[XO|YYm= NWjmNpNHSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBCPTR7IHPlcIx{KGK7IF7GMYtieHCjQjD0doFve3KncILld5Nqd25iYYPzZZktKEmFNUC9NE4xODIQvF2= MkHVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{NUezNFkoRjJzMkW3N|A6RC:jPh?=
A549 M4nTO2Z2dmO2aX;uJIF{e2G7 MV;B[49vcXO2IHHjeIl3cXS7IHH0JGdTKGmwIHj1cYFvKEF3NEmgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCudXPp[oVz[XOnIHflcoUhdGmwa3XkJJRwKE2PVG[gdJJwdW:2ZYKgZZN{\XO|ZXSgZZMhdHWlaX\ldoF{\SC2cnHud4FkfGm4YYTpc44h[WO2aY\peJktKEmFNUC9NE4xODN7OEJOwG0> M{i2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkW3N|A6Lz5{MUK1O|MxQTxxYU6=
RAW264.7 MXHBcpRqcW6obHHtcYF1d3K7IHHzd4F6 M4jIOlE5KGi{cx?= MlKzRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKHS{ZXH0[YQhOiCqcoOgZoVnd3KnIFzQV{BkcGGubHXu[4UhdWWjc4Xy[YQh[W[2ZYKgNVghcHK|IHL5JIdzcWW|czDy[YFkfGmxbjygTWM2OD1yLki2{txO MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ6OEeyO{c,OjF{OEi3Nlc9N2F-
HMC1 Mor3TY1ufW6xbX;keYxifG:{eTDhd5NigQ>? NEK1N4Y{OCCvaX7z MkLSTY1ufW6xbX;keYxifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDIUWMyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdIhwemKxbDCxNk1ugXKrc4TheIUhOTNvYXPleIF1\S:DMkOxPFcue3SrbYXsZZRm\CCLTEGtZoV1[SC|ZXPy[ZRqd25idILlZZRm\CBzIHjyJJBzcW:{IITvJFMxKG2rboOgdIhwemKxbDCxNk1ugXKrc4TheIUhOTNvYXPleIF1\S:DMkOxPFch[2ijbHzlcodmKGK7IGfld5Rmem5iYnzveJRqdmdiYX7hcJl{cXN? MnTTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MEK5OlcoRjJzM{CyPVY4RC:jPh?=
RAW264.7 M3jsNmFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NEC1bmsyQCCqcoO= Mo\aRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSk1idHCqYTDz[YNz\XSrb36gZYZ1\XJiMUigbJJ{NCCLQ{WwQVAvODIQvF2= M{joNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{WzOVQ{Lz5{MUO1N|U1OzxxYU6=
RAW264.7 NXLFcIZtSW62aXnu[oxidW2jdH;yfUBie3OjeR?= NITB[Y4zPCCqcoO= NH7HTlFCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25iYX\0[ZIhOjRiaILzJIJ6KEe{aXXzd{Bu\XSqb3SsJGlEPTB;MD64{txO MojKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NUO1OFMoRjJzM{WzOVQ{RC:jPh?=
RAW264.7 NFLZXGVCdnSraX7mcIFudWG2b4L5JIF{e2G7 MYOxNEB2VQ>? NHvUUFEzPCCqcoO= NW\EVWRRSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCOUGOtd5RqdXWuYYTl[EBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDubZRzcXSnIHzleoVtKGG2IEGwJJVOKGGodHXyJFI1KGi{czDifUBIemmnc4OgcYV1cG:mLDDBZ5Rqfmm2eU2xMlU1|ryP NVfhU2NuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOVM2PDNpPkKxN|U{PTR|PD;hQi=>
RAW264.7 NEfDcXpCdnSraX7mcIFudWG2b4L5JIF{e2G7 MoTkNlQhcHK| NVr5XIR1SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFnGUk1o[W2vYTDpcoR2[2WmIF7PJJBzd2S3Y4Tpc44h[W[2ZYKgNlQhcHK|IHL5JGdzcWW|czDy[YFkfGmxbjygTWM2OD1yLkCy{txO MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN4MUOzPEc,OjF|NkGzN|g9N2F-
RAW264.7 NV63Z492TnWwY4Tpc44h[XO|YYm= NHrCfHE{OCCvaX7z M3vLWWlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDwdoUucW6ldXLheIVlKG[xcjCzNEBucW6|IHLl[o9z\SCOUGOgZ4hidGynbnflJI1m[XO3cnXkJFYhcHK|IIDvd5QhVFCVIHPoZYxt\W6pZTDifUBGVEmVQR?= M2i5VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e1NVUzLz5{MUe3OVE2OjxxYU6=
RAW264.7 MWHGeY5kfGmxbjDhd5NigQ>? NELP[4szOCCvaX7z MUXJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJJBz\S2rbnP1ZoF1\WRiZn;yJFIxKG2rboOgZoVnd3KnIFzQV{BkcGGubHXu[4UhdWWjc4Xy[YQhOThiaILzJJBwe3RiTGDTJINp[WyuZX7n[UBjgSCJcnnld5MhdWW2aH;k NFuwWHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OVE2Oid-MkG3O|UyPTJ:L3G+
insect cells NWL2PJVNTnWwY4Tpc44h[XO|YYm= MmnFSIl{eGyjY3Xt[Y51KG:oIITleJJidWW2aInsdohw\GGvaX7lMYxi[mWuZXSgSIV5[W2ndHjhd49v\SCocn;tJIh2dWGwIILlZ49u[mmwYX70JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCrboPlZ5Qh[2WubIOgZpkh\my3b4Lld4NmdmOnIIDvcIFzcXqjdHnvckBie3OjeTygTWM2OD1yLkCwN:69VQ>? MlzPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkO5PFYoRjJzOU[zPVg3RC:jPh?=
HeLa MnO5SpVv[3Srb36gZZN{[Xl? MlrMRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDI[WxiKGOnbHzzJJRz[W6|ZnXjeIVlKHerdHigcJVkcW[ncnHz[UBo\W6nIHzpcotm\CC2bzDNUXRXKHC{b33veIVzKGG|c3Xzd4VlKGG|IHz1Z4ln\XKjc3WgeJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7LDDFR|UxRTBwMEG3{txO NXrOVXRLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlM6QDZpPkKxPVY{QTh4PD;hQi=>
insect cells NWfiZ|ViTnWwY4Tpc44h[XO|YYm= MlXySIl{eGyjY3Xt[Y51KG:oIITleJJidWW2aInsdohw\GGvaX7lMYxi[mWuZXSgSIV5[W2ndHjhd49v\SCocn;tJIh2dWGwIILlZ49u[mmwYX70JI1qdmW{YXzvZ49zfGmlb3nkJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMh[nliZnz1c5Jme2OnbnPlJJBwdGG{aYrheIlwdiCjc4PhfUwhUUN3ME2wMlA{O87:TR?= MlrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkO5PFYoRjJzOU[zPVg3RC:jPh?=
RAW264.7 MmHhRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? MWeyJIhzew>? NHf5cXBCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gdJJmfHKnYYTl[EBnd3JiMjDodpMh[mWob4LlJGxRWyClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOThiaILzJIJ6KEe{aXXzd{Bu\XSqb3SsJGlEPTB;MD60O:69VQ>? NXu2WHBSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzO|I6PTZpPkKyN|czQTV4PD;hQi=>
RAW264.7 M4O3U2FvfGmrbn\sZY1u[XSxcomgZZN{[Xl? M{LxZlIhcHK| NH:zbZNCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25icILleJJm[XSnZDDmc5IhOiCqcoOgZoVnd3KnIFzQV{BkcGGubHXu[4UhdWWjc4Xy[YQh[W[2ZYKgNVghcHK|IHL5JGdzcWW|czDt[ZRpd2RuIFnDOVA:OC57ON88US=> M{PtTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUO3N|YzLz5{MkWzO|M3OjxxYU6=
A549 NUC1dJZCSW62aXnu[oxidW2jdH;yfUBie3OjeR?= MkfaNUB2VQ>? MkSzOFghcHK| MUPBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUE0y[mW2YT3pcoR2[2WmIH3QS2VUOSCneIDy[ZN{cW:wIHH0JFEhfU1idILlZZRm\CB|MDDtbY5{KHC{aX;yJJRwKEmOLUHi[ZRiKGOqYXzs[Y5o\SCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m|IILlcIF1cX[nIITvJINwdnS{b3y= MmTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5OUW5NFAoRjJ{N{m1PVAxRC:jPh?=
H13 MlH1SpVv[3Srb36gZZN{[Xl? MoT5N{BpenN? NXH5coc1UW6qaXLpeIlwdiCxZjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCrbjDoeY1idiCKMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[E1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckBi\nSncjCzJIhzeyCkeTDbN2heNXSqeX3p[Ilv\SCrbnPvdpBwemG2aX;uJIF{e2G7LDDFR|UxRTBwMEC5O:69VQ>? M13qSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUm5OFg2Lz5{M{G5PVQ5PTxxYU6=
293 MSR NIrHeYNHfW6ldHnvckBie3OjeR?= M2HDNlYxKG2rboO= M1X0VWRqe3CuYXPlcYVvfCCxZjDbN2heNWSneHHt[ZRp[XOxbnWgbJVu[W5iZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5Ih[WyyaHGg[ZhxemW|c3XkJIlvKDJ7MzDNV3Ih[2WubIOgZYZ1\XJiNkCgcYlveyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCHQ{WwQVAvODF{Nd88US=> MlO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzOUm0PFUoRjJ|MUm5OFg2RC:jPh?=
IOBA-NHC Mo\RSpVv[3Srb36gZZN{[Xl? MXe0NEB2VQ>? M4jINlI1KGi{cx?= Ml3GTY5pcWKrdHnvckBw\iCQRj3rZZBx[UJicE[1MY1m\GmjdHXkJHRPTmGucHjhJJJmdGWjc3WgbY4hUFOYMTDLU3MhcW6oZXP0[YQhcHWvYX6gTW9DSS2QSFOgZ4VtdHNiYYSgOFAhfU1iYX\0[ZIhOjRiaILzJIJ6KEWOSWPB M2rtU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkG5PFU2Lz5{M{KxPVg2PTxxYU6=
IOBA-NHC MYPGeY5kfGmxbjDhd5NigQ>? MkmyOFAhfU1? NH3VW2UzPCCqcoO= M2HwRmlvcGmkaYTpc44hd2ZiTl[tb4FxeGGEIIC2OU1u\WSrYYTl[EBKVC14IILlcIVie2ViaX6gTHNXOSCNT2OgbY5n\WO2ZXSgbJVu[W5iSV;CRU1PUENiY3XscJMh[XRiNECgeW0h[W[2ZYKgNlQhcHK|IHL5JGVNUVOD NWW5RWZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNVk5PTVpPkKzNlE6QDV3PD;hQi=>
IOBA-NHC MXPGeY5kfGmxbjDhd5NigQ>? NXXmfFI6PDBidV2= NYHZVlFEOjRiaILz MnmyTY5pcWKrdHnvckBw\iCQRj3rZZBx[UJicE[1MY1m\GmjdHXkJGlNNThicnXs[YF{\SCrbjDIV3YyKEuRUzDpcoZm[3SnZDDoeY1idiCLT1LBMW5JSyClZXzsd{BifCB2MDD1UUBi\nSncjCyOEBpenNiYomgSWxKW0F? MkXuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{MUm4OVUoRjJ|MkG5PFU2RC:jPh?=
HCLE MoLFSpVv[3Srb36gZZN{[Xl? NGW0fXg1OCC3TR?= NUT4fYl[OjRiaILz NIHsT5BKdmirYnn0bY9vKG:oIF7GMYtieHCjQjDwOlUudWWmaXH0[YQhUUxvODDy[Yxm[XOnIHnuJGhUXjFiS1;TJIlv\mWldHXkJIh2dWGwIFjDUGUh[2WubIOgZZQhPDBidV2gZYZ1\XJiMkSgbJJ{KGK7IFXMTXNC NHOxXHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KxPVg2PSd-MkOyNVk5PTV:L3G+
HCT116 NGO4NIJHfW6ldHnvckBie3OjeR?= MkfZNlAhfG9iNECgeW0> NGDlR48zPCCqcoO= MkTyRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDIR3QyOTZiY3XscJMh[29vZYjwdoV{e2mwZzDHVmUh[XRiMkCgeI8hPDBidV2gZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> Ml7uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{N{[0OFkoRjJ|Mke2OFQ6RC:jPh?=
RAW264.7 MoTYRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NVj2OVhLOiCqcoO= NFfkdoNCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgUm8heHKxZIXjeIlwdiCrbnP1ZoF1\WRiZn;yJFIhcHK|IIDybY9zKHSxIFzQV{1kcGGubHXu[4UhdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JGdzcWW|czDt[ZRpd2RuIFnDOVA:OS52M988US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN5M{m2OUc,OjN|N{O5OlU9N2F-
HeLaS3 M4TpdmZ2dmO2aX;uJIF{e2G7 NX\temVkOiCqcoO= M3;3fGRqe3CuYXPlcYVvfCCxZjDbN2heTGW6YX3leIhie2:wZTDmdo9uKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGhmVGGVMzDj[YxteyCjZoTldkAzKGi{czygT4k:OC5yMEKy{txO MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRyM{C4Nkc,OjN2MEOwPFI9N2F-
HeLaS3 MXPGeY5kfGmxbjDhd5NigQ>? NWHhOW44OiCqcoO= M33pdmRqe3CuYXPlcYVvfCCxZjDbN2heTGW6YX3leIhie2:wZTDmdo9uKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGhmVGGVMzDj[YxteyCjZoTldkAzKGi{czygTWM2OD1yLkCwOFHPxE1? NEPJ[VY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SwN|A5Oid-MkO0NFMxQDJ:L3G+
A549 MkKwSpVv[3Srb36gZZN{[Xl? M4PscnRz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gTWwy[mW2YT3zeIlufWyjdHXkJG5Hc2GycHHCMYRmeGWwZHXueEBGNXOnbHXjeIlvKHS{YX7zZ5JqeHSrb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwMECxNe69VQ>? M{\vWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUG2OVk1Lz5{M{mxOlU6PDxxYU6=
A549 MkXJSpVv[3Srb36gZZN{[Xl? NHzyXHNVemGwc4LldJJme3Orb36gZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHBOSS2|dHnteYxifGWmIFHQNUBz\XOyb37z[UBmdGWvZX70JIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkCwNlXPxE1? MmDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7MU[1PVQoRjJ|OUG2OVk1RC:jPh?=
Hela NXywb4V5TnWwY4Tpc44h[XO|YYm= MmDXWJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHzp[4Fv\CCkaX7kbY5oKGSxbXHpckApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCqdX3hckBJ\WyjIHPlcIx{KGOxLXX4dJJme3OrbnegS2FNPCCGTlGgZolv\GmwZzDkc41icW5iYYPz[ZN{\WRiYYOgUnAuOS2|dHnteYxifGWmIFfSSUBi[3SrdnH0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAxPDYQvF2= NIHITFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mxOlU6PCd-MkO5NVY2QTR:L3G+
A549 M4DmRWZ2dmO2aX;uJIF{e2G7 NF\1OoxC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBKVC1zYnX0ZU1qdmS3Y3XkJG5HNWujcIDhRkBl\XCnbnTlcpQhTS2|ZXzlZ5RqdiCjY4TpeoF1cW:wIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjByMUJOwG0> NWLqSG86RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OVMxPzBpPkKzPVU{ODdyPD;hQi=>
A549 NFjhO4hHfW6ldHnvckBie3OjeR?= M{Wz[WFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHBOSS2rbnT1Z4VlKEGSLUGgZYN1cX[jdHnvckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wNFI2|ryP NFTvd289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m1N|A4OCd-MkO5OVMxPzB:L3G+
HeLa MWHGeY5kfGmxbjDhd5NigQ>? NGTaPI9VemGwc3HjeIl3[XSrb36gc4Yh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{Bi[3SrdnH0bY9vKG:oIF7QMVEh[nliR1HMOEBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMES1{txO NGDOepE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m1N|A4OCd-MkO5OVMxPzB:L3G+
A549 M1rJNmZ2dmO2aX;uJIF{e2G7 MlzHWJJidnO{ZYDy[ZN{cW:wIH;mJIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDQUWEucW6mdXPl[EBCWC1zIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjByMkZOwG0> NYjqfo02RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVE3PDRpPkK0NFEyPjR2PD;hQi=>
HeLa MUPGeY5kfGmxbjDhd5NigQ>? Mo\LWJJidnOjY4TpeoF1cW:wIH;mJGdTNUyERDDlfJBz\XO|ZXSgbY4hcHWvYX6gTIVN[SClZXzsd{Bkdy2neIDy[ZN{cW6pIFfBUFQuTEKGIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjByNENOwG0> M4n4TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGxOlQ1Lz5{NECxNVY1PDxxYU6=
HEK293 M371R2Z2dmO2aX;uJIF{e2G7 MX\EbZNxdGGlZX3lcpQhd2ZiW{PIYU1idGSxc4Tldo9v\SCocn;tJIh2dWGwIH3pcoVz[WyxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpQVAvODByM{dOwG0> NH21RpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES0OlczQCd-MkS0OFY4Ojh:L3G+
HEK293 MXLGeY5kfGmxbjDhd5NigQ>? MkTDSIl{eGyjY3Xt[Y51KG:oIGuzTH0u\GW6YX3leIhie2:wZTDmdo9uKGi3bXHuJIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpQVAvODByNkpOwG0> NHzkSWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES0OlczQCd-MkS0OFY4Ojh:L3G+
HEK293 MmLnSpVv[3Srb36gZZN{[Xl? NFzrXW1FcXOybHHj[Y1mdnRib3[gX|NJZS2vZYTofYx1emmnbn;sc45mKG[{b32gbJVu[W5icILv[4V{fGW{b37lJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOsJGtqRTBwNU[x{txO MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR2NkeyPEc,OjR2NE[3Nlg9N2F-
HEK293 MUHGeY5kfGmxbjDhd5NigQ>? NXS3c|FoTGm|cHzhZ4Vu\W62IH;mJHs{UF1vbXX0bJltfHKrZX7vcI9v\SCocn;tJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpQVEvPDIQvF2= NV\3e4FmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0OFY4OjhpPkK0OFQ3PzJ6PD;hQi=>
HeLa NYfIWVR4TnWwY4Tpc44h[XO|YYm= NFnNe3lVemGwc3HjeIl3[XSrb36gc4Yh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gTIVN[SClZXzsd{Bp[XKkb4LpcochVU2WVjDwdo9ud3SncjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMUhOwG0> NV7O[HExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2OVY2PjVpPkK0OlU3PTZ3PD;hQi=>
A549 MYPGeY5kfGmxbjDhd5NigQ>? NFnQXGZC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiRT3z[Yxm[3SrbjD0doFve3KncILld5Nqd25iYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODBzMd88US=> NWf0SoNNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PFAxPTNpPkK0PVgxODV|PD;hQi=>
A549 Mn\5SpVv[3Srb36gZZN{[Xl? M3GwOWFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCDUD2xJJRz[W6|cnXwdoV{e2mxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMEK1{txO NHfkcZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm4NFA2Oyd-MkS5PFAxPTN:L3G+
HeLa NF;XOGlHfW6ldHnvckBie3OjeR?= NFqzWmNC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGhmVGFiY3XscJMh[XO|ZYPz[YQh[XNiTmCtNUB1emGwc3HjeIl3[XSrb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwMEC0Oe69VQ>? M1XGcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUiwNFU{Lz5{NEm4NFA2OzxxYU6=
B16F10 NITCN3VCdnSrdIXtc5Ih[XO|YYm= NWTvdHd2OjBibXevb4c> MVeyOEBl[Xm| NUTCN4lZSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRlE3TjFyIHPlcIx{KHinbn;ndoFnfGWmIHnuJGM2P0KOL{[gcY92e2ViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckB1fW2xcjDndo94fGhiYYSgNlAhdWdxa3esJIlxKG2nYYP1doVlKGGodHXyJFI1KGSjeYOgc4YhfHWvb4KgbY5w[3WuYYTpc44> NWW0eWYyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVIxPzFpPkK0PVkzODdzPD;hQi=>
B16F10 MVzBcpRqfHWvb4KgZZN{[Xl? M2K2bFIxKG2pL3vn NGjWNY0zPCCmYYnz MnHVRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQkG2SlExKGOnbHzzJJhmdm:pcnHmeIVlKGmwIFO1O2JNNzZibX;1d4Uh[XO|ZYPz[YQh[XNiYYDvdJRwfGmlIILl[4lwdnNiYYSgNlAhdWdxa3esJIlxKG2nYYP1doVlKGGodHXyJFI1KGSjeYOgc4YhfHWvb4KgbY5w[3WuYYTpc44h[nliVGXOSWwh[XO|YYm= M{jFTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUmyNFcyLz5{NEm5NlA4OTxxYU6=
B16F10 Mk\DRY51cXS3bX;yJIF{e2G7 MVqyNEBu\y:tZx?= NET0[3MzPCCmYYnz MX\BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEMU\GNVAh[2WubIOgfIVvd2e{YX\0[YQhcW5iQ{W3RmwwPiCvb4Xz[UBie3Onc4Pl[EBieyCjcH;weI91cWNicnXnbY9veyCjdDCyNEBu\y:tZzygbZAhdWWjc4Xy[YQh[W[2ZYKgNlQh\GG7czDv[kB1fW2xcjDpco9kfWyjdHnvckBjgSCYRT3jZYRp\XKrbh?= NX7FXoM4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVIxPzFpPkK0PVkzODdzPD;hQi=>
B16F10 NGnMT4dCeG:ydH;zbZMh[XO|YYm= NHX4TVUyOCC3TR?= MV[0PEBpenN? MWPJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIH3veZNmKEJzNl[xNEBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiC{YYTpc{Bw\iCEQWivRoNtOiCneIDy[ZN{cW:wIHH0JFExKHWPIHHmeIVzKDR6IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYOgdoVt[XSrdnWgeI8hfW62cnXheIVlKGOxboTyc4w> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7MkC3NUc,OjR7OUKwO|E9N2F-
CUTLL1 NWPZT21UT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml[yOFghcHK| MkSxS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR3VVVExzIHPlcIx{KHerdHigbIlocCCJUjDlfJBz\XO|aX;uJIxmfmWuczDh[pRmeiB2ODDodpMh[nliYXzhcYFzKGKudXWgZZN{[Xl? M2jtNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEWwNVYxLz5{NUC1NFE3ODxxYU6=
HEK293 NIPONmpHfW6ldHnvckBie3OjeR?= NV7aOGNUSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBIS1JiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xODF|zszN MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MEW2PFgoRjJ3M{C1Olg5RC:jPh?=
RAW264.7 MVLGeY5kfGmxbjDhd5NigQ>? NHHidoEzPCCqcoO= NYPVWnRHUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjZoTldkAzPCCqcoOgZpkhT3KrZYPzJIF{e2G7IILlcIF1cX[nIITvJJZmcGmlbHWteJJm[XSnZDDjc451em:uLDDJR|UxRTBwON88US=> MmfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUm4PFIoRjJ3NEm5PFgzRC:jPh?=
HFF NFjmRm1HfW6ldHnvckBie3OjeR?= MUjB[49vcXO2IHHjeIl3cXS7IHH0JGdTKGmwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDJUE0yNWmwZIXj[YQhUUxvNjDwdo9lfWO2aX;uMEBKSzVyPUCuNFAy|ryP NWLmS4pFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NVY4QTFpPkK1OVE3PzlzPD;hQi=>
RAW264.7 NIP1VGhCdnSraX7mcIFudWG2b4L5JIF{e2G7 MXqxJI1O MYKzNEBucW6| M{\JNWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gUHBUNWmwZIXj[YQhXE6IIH3SUmEh\XiycnXzd4lwdiClZXzsd{BifCBzIH3NJJRz\WG2ZXSgN|AhdWmwczDi[YZwemViTGDTJINp[WyuZX7n[UBu\WG|dYLl[EBi\nSncjCzJIhzeyCkeTDxVnQuWEOUIHHuZYx6e2m| NVPOXodjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2Olc6PjBpPkK1OlY4QTZyPD;hQi=>
SW1353 MYrGeY5kfGmxbjDhd5NigQ>? M1vVUVI1KGi{cx?= NE\hOYJVemGwc4LldJJme3Orb36gZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gV3cyOzV|IHPlcIx{KGG|c3Xzd4VlKGG|IILldJJme3Orb36gc4YhUUxvMT3pcoR2[2WmIF3NVE0yOyCycn;keYN1cW:wIHHmeIVzKDJ2IHjyd{BjgSCHTFnTRUwhUUN3ME2wMlAxOTkQvF2= MoPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5ME[xNFAoRjJ3N{C2NVAxRC:jPh?=
RAW264.7 M{HWbWZ2dmO2aX;uJIF{e2G7 MkPwOkBpenN? NIjVW2JKdmirYnn0bY9vKG:oIGTOSoFteGijIIDyc4R2[3Srb36gbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiaX7jeYJifGWmIH\vdkA3KGi{czDifUB{[W6md3njbEBqdW23bn;hd5NigSxiSVO1NF0xNjB2zszN MmGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MkS2OlIoRjJ3OEK0OlYzRC:jPh?=
J774A.1 M{HB[mZ2dmO2aX;uJIF{e2G7 MkjnOkBpenN? NFXCOZZKdmirYnn0bY9vKG:oIGTOSoFteGijIIDyc4R2[3Srb36gbY4hdW:3c3WgTlc4PEFwMTDj[YxteyCrbnP1ZoF1\WRiZn;yJFYhcHK|IHL5JJNidmS5aXPoJIludXWwb3Hzd4F6NCCLQ{WwQVAvPM7:TR?= M{HLSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK0OlYzLz5{NUiyOFY3OjxxYU6=
RAW264.7 M1z1PGZ2dmO2aX;uJIF{e2G7 MXexNkBpenN? MUDJcohq[mm2aX;uJI9nKEmOLUHi[ZRiKHC{b3T1Z5Rqd25iaX6gcY92e2ViUlHXNlY1NjdiY3XscJMhcW6ldXLheIVlKG[xcjCxNkBpenNiYomgd4Fv\HerY3igbY1ufW6xYYPzZZktKEmFNUC9OE44|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{NE[2Nkc,OjV6MkS2OlI9N2F-
J774A.1 MnjCSpVv[3Srb36gZZN{[Xl? M{Hoe|EzKGi{cx?= NX64XZJsUW6qaXLpeIlwdiCxZjDJUE0y[mW2YTDwdo9lfWO2aX;uJIlvKG2xdYPlJGo4PzSDLkGgZ4VtdHNiaX7jeYJifGWmIH\vdkAyOiCqcoOgZpkhe2GwZIfpZ4ghcW2vdX7vZZN{[XluIFnDOVA:OjMQvF2= NWnTfppGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NlQ3PjJpPkK1PFI1PjZ{PD;hQi=>
RAW264.7 NGDkfYpCdnSraX7mcIFudWG2b4L5JIF{e2G7 M2TnUlI1KGi{cx?= MlfRRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFI1KGi{czDifUBIemmnc4OgZZN{[XluIFnDOVA:OC54M988US=> NEXSZpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC4O|M5PCd-Mk[wPFc{QDR:L3G+
BV2 NV24XHdOSW62aXnu[oxidW2jdH;yfUBie3OjeR?= MkDnNlQhcHK| NHnx[GZCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKEN3N1LMOk9LKG2xdYPlJGJXOiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKG6rdILpZ{BwgGmmZTDwdo9lfWO2aX;uJIFnfGW{IEK0JIhzeyCkeTDHdolme3NiYYPzZZktKEmFNUC9NE4xOjYQvF2= NEjwc209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGxNFQ1Oyd-Mk[xNVA1PDN:L3G+
RAW264.7 NVHkbHRFTnWwY4Tpc44h[XO|YYm= NWnyd2lWOjRiaILz NITCfmJKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFI1KGi{czDifUBIemmnc4OgZZN{[XluIFnDOVA:OC56zszN Mn3SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MEW0NFYoRjJ4M{C1OFA3RC:jPh?=
J774 M4LzUmFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NUDCdIJwOTBidV2= MXOyOEBpenN? Mk\wRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEp5N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDpUm9UKGW6cILld5Nqd25iYYSgNVAhfU1iYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjlzNUm5PEc,OjZ7MUW5PVg9N2F-
IM9 NFPGVmNHfW6ldHnvckBie3OjeR?= M1XuWmRqe3CuYXPlcYVvfCCxZjDbN2he\GW6YX3leIhie2:wZTDmdo9uKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGlOQSClZXzsd{whUUN3ME2wMlAxOzkQvF2= M{PuPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUi4PFAyLz5{Nkm4PFgxOTxxYU6=
inflammatory cells MnXHRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NH;5[3oyOCCvZz;r[y=> M1jIelYhfG9iMkSgbJJ{ NXnIU4Y5SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCFNUfCUE83KG2xdYPlJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gfplud3Ojbj3pcoR2[2WmIHnu[oltfHKjdHnvckBw\iCrbn\sZY1u[XSxcomgZ4VtdHNiaX70c{B{gW6xdnnhcEB1cXO|dXWgZZQhOTBibXevb4ctKGmyIHHkcYlvcXO2ZYLl[EAyKGi{IIDybY9zKHSxIIr5cY9{[W5iY3jhcIxmdmenIH3lZZN2emWmIHH0JFYhfG9iMkSgbJJ{KGK7IHjlcYF1d3i7bHnuJIFv\CCnb4PpckB{fGGr M4PE[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MkK3OFU6Lz5{N{KyO|Q2QTxxYU6=
mononuclear cells MonLRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NUn0e|h2OTBibXevb4c> MlvUOkB1dyB{NDDodpM> MXXBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJGM2P0KOL{[gcY92e2ViYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC8eX3vd4FvNWmwZIXj[YQhdW:wb371Z4xm[XJiY3XscJMhdWmpcnH0bY9vKGmwIHHyeIlkfWyjcjDjZZZqfHliYYSgNVAhdWdxa3esJIlxKGGmbXnubZN1\XKnZDCxJIhzKHC{aX;yJJRwKHq7bX;zZY4h[2ijbHzlcodmKG2nYYP1doVlKGG2IE[geI8hOjRiaILz M4P1e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MkK3OFU6Lz5{N{KyO|Q2QTxxYU6=
J774A.1 Mm\jRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NHXhZ2UyKHWP M2jhSVEhcHJ? Mn7YRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDKO|c1SS5zIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhgnmvb4PhckBidmRiSV\O[4FudWFvaX7keYNm\CCLTE[gdJJw\HWldHnvckBqdiClZXzsMYZz\WVic4Xw[ZJv[XSjboSgZZQhOSC3TTDwdoVqdmO3YnH0[YQh\m:{IEGgbJIh\m:ubH;3[YQh[nlieontc5NidiCjbnSgTWZP\2GvbXGgZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IIPhcoR4cWOqIFXMTXNC NXyxTnZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNlc1PTlpPkK3NlI4PDV7PD;hQi=>
J774A.1 NILIeGNCdnSraX7mcIFudWG2b4L5JIF{e2G7 M{TFUlEhfU1? NHLNSWwyKGi{ NW\pbnhSSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBLPzd2QT6xJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2Zieontc5NidiCjbnSgTWZP\2GvbXGtbY5lfWOnZDDDU3gzKGW6cILld5Nqd25iYYSgNUB2VSCycnXpcoN2[mG2ZXSg[o9zKDFiaIKg[o9tdG:5ZXSgZpkhgnmvb4PhckBidmRiSV\O[4FudWFiYXTkbZRqd25ibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJ{N{S1PUc,Ojd{Mke0OVk9N2F-
J774A.1 Ml;RRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NEPieFkyKHWP NIHCN4kyKGi{ MkPaRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDKO|c1SS5zIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhgnmvb4PhckBidmRiSV\O[4FudWFvaX7keYNm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBifCBzIIXNJJBz\WmwY4XiZZRm\CCob4KgNUBpeiCob3zsc5dm\CCkeTD6fY1we2GwIHHu[EBKTk6pYX3tZUBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgZ49td3KrbXX0dolkKEe{aXXzd{B1\XO2 NEDuc2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{KyO|Q2QSd-MkeyNlc1PTl:L3G+
RAW264.7 NHLqdnFCdnSraX7mcIFudWG2b4L5JIF{e2G7 M3fJfFI1KGi{cx?= Mo\aRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFI1KGi{czDpckBxemW|ZX7j[UBw\iCOUGOgZpkhT3KrZYPzJIF{e2G7LDDJR|UxRTBwNkROwG0> MojjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6MkW1OFUoRjJ5OEK1OVQ2RC:jPh?=
IM9 NFnYb5BHfW6ldHnvckBie3OjeR?= NIDZOVZFcXOybHHj[Y1mdnRib3[gX|NJZWSneHHt[ZRp[XOxbnWg[pJwdSCJUjDy[YNmeHSxcjDpckBpfW2jbjDJUVkh[2WubIOsJGlEPTB;MD6wNFM5|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh5NkK1NEc,Ojd6N{[yOVA9N2F-
HeLa MoHtSpVv[3Srb36gZZN{[Xl? M1LT[3Rz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcnnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDUVGEucW6mdXPl[EBkd2yuYXflcoF{\SCycn;tc5RmeiCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NE4xODF3OEZOwG0> NGe3TZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC0N|c6Pid-MkiwOFM4QTZ:L3G+
THP1 M4XldGZ2dmO2aX;uJIF{e2G7 MV;UdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iVFjQNUBk\WyuczDhd5Nme3OnZDDhd{Bz\WOncITvdk1u\WSrYYTl[EBidnSrLXnu[oxidW2jdH;yfUBi[3Srdnn0fUBjgSCvZXHzeZJqdmdiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCLTD24JJBzd2S3Y4Tpc44tKEmFNUC9NE4xODJ3MUNOwG0> NYfWUWNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwOFM4QTZpPkK4NFQ{Pzl4PD;hQi=>
HeLa MYrGeY5kfGmxbjDhd5NigQ>? MXHUdoFve2GldHn2ZZRqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiTV3UWkBxem:vb4TldkBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MD6wNFc6PDQQvF2= NFjtN4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC0N|c6Pid-MkiwOFM4QTZ:L3G+
Sf9 MnTwSpVv[3Srb36gZZN{[Xl? MkTPRolv\GmwZzDh[oZqdmm2eTD0c{Bz\WOxbXLpcoFvfCCqdX3hckBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRic3[5JINmdGy|LDDJR|UxRTBwMEGyOVnPxE1? M3PMUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MESzO|k3Lz5{OEC0N|c6PjxxYU6=
RAW264.7 MnrPRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NHHkW2I{OCCvaX7z M{\Zb2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEySUz3pcoR2[2WmIF7PJJBzd2S3Y4Tpc44heHKndILlZZRm\CCob4KgN|AhdWmwczDmc4xtd3enZDDifUBNWFNic4TpcZVt[XSrb36g[o9zKDJ2IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;N988US=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR7OUezN{c,Ojh2OUm3N|M9N2F-
RAW264.7 MoHCSpVv[3Srb36gZZN{[Xl? MXWyOEBpenN? NGO4dlNKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJG5QKHC{b3T1Z5Rqd25iaX6gcY92e2ViUlHXNlY1NjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGdzcWW|czDhd5NigSxiSVO1NF0zNjYQvF2= NIrqSXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW5PFY{Oyd-Mki1PVg3OzN:L3G+
Mino M3;CPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGrwVpYyODBidV2= MoO1OFghcHK| NIf5cHZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3pco8h[2WubIOgZZQhOTByIIXNJJBz\WmwY4XiZZRm\CCob4KgOFghcHK|IH\vcIxwf2WmIHL5JJRpgW2rZHnu[UBi\GSrdHnvckBu\WG|dYLlJIFnfGW{IEG2JIhzeyCkeTDUbJlucWSrbnWgbY5kd3Kyb4LheIlwdiCjc4PhfS=> NUT0c3E4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4OVg2OTFpPkK4PFU5PTFzPD;hQi=>
RAW264.7 M{DtXGFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NEnvd|lCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25iYomg[5Jq\XO|IHHzd4F6NCCLQ{WwQVAvQM7:TR?= MmTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl{N{KxNlYoRjJ7MkeyNVI3RC:jPh?=
RAW264.7 M1j4[2Z2dmO2aX;uJIF{e2G7 NGH1V|MyOCC3TR?= MoG3NUBpeg>? NF7Wd4NC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SCrbjDMVHMue3SrbYXsZZRm\CCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIF7GMYtieHCjQjDzbYdv[WyrbnegZpkhdWWjc4XybY5oKHKnZIXjeIlwdiCrbjDpUm9UKHC{b4TlbY4hdGW4ZXygZZQhOTBidV2gdJJmfHKnYYTl[EB4cXSqIHPvcZBwfW6mIH\vdkAyKGi{IH\vcIxwf2WmIHL5JGxRWyC|dHnteYxifGmxbjDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nl? M1\zT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{i5NVIyLz5{OUO4PVEzOTxxYU6=
RAW264.7 NVm5UVBWTnWwY4Tpc44h[XO|YYm= M{niZ|ExKHWP NYLUPIZtOSCqch?= MYHB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVKpYX3tZUBqdiCOUGOtd5RqdXWuYYTl[EBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKE6ILXvhdJBiSiC|aXfuZYxqdmdiYomgcYVie3W{aX7nJJJm\HWldHnvckBqdiCQTzDwdo9lfWO2aX;uJIF1KDFyIIXNJJBz\XS{ZXH0[YQhf2m2aDDjc41xd3WwZDDmc5IhOSCqcjDmc4xtd3enZDDifUBNWFNic4TpcZVt[XSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFfybYU> M4OzUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{i5NVIyLz5{OUO4PVEzOTxxYU6=
RAW264.7 M2LnW2Z2dmO2aX;uJIF{e2G7 MnfmNVAhfU1? NYTnVGFSOSCqch?= M4jtcWFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGmwIFzQV{1{fGmvdXzheIVlKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTl[tb4FxeGGEIIPp[45idGmwZzDifUBu\WG|dYLpcochemWmdXP0bY9vKGmwIFnMMVFj\XSjIIDyc4R2[3Srb36gZZQhOTBidV2gdJJmfHKnYYTl[EB4cXSqIHPvcZBwfW6mIH\vdkAyKGi{IH\vcIxwf2WmIHL5JGxRWyC|dHnteYxifGmxbjDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[g>? NVHQNo1wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzPFkyOjFpPkK5N|g6OTJzPD;hQi=>
RAW264.7 M3\ZZmZ2dmO2aX;uJIF{e2G7 NFS5W5YyOCC3TR?= M1zJZlEhcHJ? MkL0RYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhcW5iTGDTMZN1cW23bHH0[YQhdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCQRj3rZZBx[UJic3nncoFtcW6pIHL5JI1m[XO3cnnu[{Bz\WS3Y4Tpc44hcW5iSVytOkBxem:mdXP0bY9vKGG2IEGwJJVOKHC{ZYTy[YF1\WRid3n0bEBkd22yb4Xu[EBnd3JiMTDodkBnd2yub4fl[EBjgSCOUGOgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgNlQhcHK|IHL5JGVN NYXDRmI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzPFkyOjFpPkK5N|g6OTJzPD;hQi=>
RAW264.7 NVPkXphvTnWwY4Tpc44h[XO|YYm= MV6xNEB2VQ>? MV2xJIhz NV3vSJFySWexbnnzeEBi[3Srdnn0fUBifCCSUFHS[4FudWFiaX6gUHBUNXO2aX31cIF1\WRibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDOSk1s[XCyYVKgd4lodmGuaX7nJIJ6KG2nYYP1dolv\yC{ZXT1Z5Rqd25iaX6gWG5H[WyyaHGgdJJw\HWldHnvckBifCBzMDD1UUBxemW2cnXheIVlKHerdHigZ49ueG:3bnSg[o9zKDFiaIKg[o9tdG:5ZXSgZpkhVFCVIIP0bY12dGG2aX;uJI1m[XO3cnXkJIFnfGW{IEOgbJJ{KGK7 MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTN6OUGyNUc,Ojl|OEmxNlE9N2F-
RAW264.7 M{GzdGZ2dmO2aX;uJIF{e2G7 MorMNVAhfU1? NGq2ZXUyKGi{ M1L3fGFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGmwIFzQV{1{fGmvdXzheIVlKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTl[tb4FxeGGEIIPp[45idGmwZzDifUBu\WG|dYLpcochemWmdXP0bY9vKGmwIHnOU3MhdVKQQTDs[ZZmdCCjdDCxNEB2VSCycnX0doVifGWmIIfpeIgh[2:vcH;1coQh\m:{IEGgbJIh\m:ubH;3[YQh[nliTGDTJJN1cW23bHH0bY9vKG[xcjC2JIhzeyCkeTDSWE1RS1JiYX7hcJl{cQ>? Mn63QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|OEmxNlEoRjJ7M{i5NVIyRC:jPh?=
RAW264.7 M{jQZmZ2dmO2aX;uJIF{e2G7 NYjsOItzOTBidV2= NF3rSVYyKGi{ M{PNTmFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGmwIFzQV{1{fGmvdXzheIVlKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTl[tb4FxeGGEIIPp[45idGmwZzDifUBu\WG|dYLpcochemWmdXP0bY9vKGmwIFPPXFIhdVKQQTDs[ZZmdCCjdDCxNEB2VSCycnX0doVifGWmIIfpeIgh[2:vcH;1coQh\m:{IEGgbJIh\m:ubH;3[YQh[nliTGDTJJN1cW23bHH0bY9vKG[xcjC2JIhzeyCkeTDSWE1RS1JiYX7hcJl{cQ>? NF7TOXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO4PVEzOSd-MkmzPFkyOjF:L3G+
RAW264.7 M3rleWZ2dmO2aX;uJIF{e2G7 MmT5NVAhfU1? NFT2eVIyKGi{ NGjnUmJC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SCrbjDMVHMue3SrbYXsZZRm\CCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIF7GMYtieHCjQjDzbYdv[WyrbnegZpkhdWWjc4XybY5oKHKnZIXjeIlwdiCrbjDUUmZidHCqYTDtVm5CKGyndnXsJIF1KDFyIIXNJJBz\XS{ZXH0[YQhf2m2aDDjc41xd3WwZDDmc5IhOSCqcjDmc4xtd3enZDDifUBNWFNic4TpcZVt[XSrb36g[o9zKDZiaILzJIJ6KFKWLWDDVkBidmF? NHL3T5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO4PVEzOSd-MkmzPFkyOjF:L3G+
RAW264.7 MnTISpVv[3Srb36gZZN{[Xl? MlTkNVAhfU1? NVjHe5lYOSCqch?= M2TVXmFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGmwIFzQV{1{fGmvdXzheIVlKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTl[tb4FxeGGEIIPp[45idGmwZzDifUBu\WG|dYLpcochemWmdXP0bY9vKGmwIFnMMVFj\XSjIH3SUmEhdGW4ZXygZZQhOTBidV2gdJJmfHKnYYTl[EB4cXSqIHPvcZBwfW6mIH\vdkAyKGi{IH\vcIxwf2WmIHL5JGxRWyC|dHnteYxifGmxbjDmc5IhPiCqcoOgZpkhWlRvUFPSJIFv[Q>? NYXhdJA3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzPFkyOjFpPkK5N|g6OTJzPD;hQi=>
RAW264.7 MV;GeY5kfGmxbjDhd5NigQ>? MX2xNEB2VQ>? NYLv[phVOSCqch?= NVW4fVliSWexbnnzeEBi[3Srdnn0fUBifCCSUFHS[4FudWFiaX6gUHBUNXO2aX31cIF1\WRibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDOSk1s[XCyYVKgd4lodmGuaX7nJIJ6KG2nYYP1dolv\yC{ZXT1Z5Rqd25iaX6gTWwuPiCvUl7BJIxmfmWuIHH0JFExKHWPIIDy[ZRz\WG2ZXSge4l1cCClb33wc5Vv\CCob4KgNUBpeiCob3zsc5dm\CCkeTDMVHMhe3SrbYXsZZRqd25iZn;yJFYhcHK|IHL5JHJVNVCFUjDhcoFtgXOr NH\XdI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUO4PVEzOSd-MkmzPFkyOjF:L3G+
SK-N-MC NF:2c3ZyUFSVIHHzd4F6 M13KcZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz M3WxT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BV2 M37xdWFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? Ml;tRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDCWlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjygTWM2OD17LkZOwG0> NUDoUVRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0PFI6PDBpPkK5OFgzQTRyPD;hQi=>
RAW264.7 NIPucVZHfW6ldHnvckBie3OjeR?= MnnONlQhcHK| NHTFWllKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGGodHXyJFI1KGi{czDifUBIemmnc4OgZZN{[XluIFnDOVA:OTBwN988US=> NY[2R2JmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1NVg{OjZpPkK5OVE5OzJ4PD;hQi=>
HeLa MmTTSpVv[3Srb36gZZN{[Xl? NULQUJdPOC52IIXN NUXSV4M4OjRiaILz NYPveYgxXHKjboPy[ZBz\XO|aX;uJI9nKEeFUjDpckBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KHO3cIDy[ZN{cW:wIH;mJGRGYC2rbnT1Z4VlKEeLTGqgcXJPSSCneIDy[ZN{cW:wIHH0JFAvPCC3TTDh[pRmeiB{NDDodpMh[nliVHHxcYFvNWKjc3XkJJJm[WxvdHnt[UBRS1JiYX7hcJl{cXN? M4fIbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkewOlk4Lz5{OU[3NFY6PzxxYU6=
RAW264.7 MWrBcpRqcW6obHHtcYF1d3K7IHHzd4F6 MYrBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVLXnu[JVk\WRiTl:gdJJw\HWldHnvckwhUUN3ME24MlPPxE1? NVXFUnlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3OFE{PzJpPkK5O|QyOzd{PD;hQi=>
HEK 293T NVHm[G82TnWwY4Tpc44h[XO|YYm= NWm1cHdKSWexbnnzeEBi[3Srdnn0fUBifCCJQVy0JGRPSS2kaX7kbY5oKGSxbXHpckBnfXOnZDDHVkApfW6tbn;3ckBwemmpaX6pJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCneIDy[ZN{\WRiaX6gWWFUNWKuYTDISWshOjl|VDDj[YxteyCjc4Pld5Nm\CCjczDi[ZRiNWyjY4ThcYF{\SC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCkeTDGVmVVNWKjc3XkJGdmdmWETFH6[ZIh[XO|YYmsJGlEPTB;MD6wNFI{Pc7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF2NE[5O{c,OzBzNES2PVc9N2F-
RAW264.7 NWPIcZJ5SW62aXnu[oxidW2jdH;yfUBie3OjeR?= NVftZY02OjBidV2= MYK2JIhzew>? MlnvRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhdmm2cnn0[UBxem:mdXP0bY9vKGG2IEKwJJVOKHC{ZYTy[YF1\WRiZn;yJFYhcHK|IH\vcIxwf2WmIHL5JGxRWyC|dHnteYxifGmxbjDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliRVzJV2E> NXPEOYlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVUzPTVpPkOwNlE2OjV3PD;hQi=>
RAW264.7 NYPUTWdCSW62aXnu[oxidW2jdH;yfUBie3OjeR?= NFzWWmkzOCC3TR?= NWLpXlQxPiCqcoO= MnrxRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhXE6IYXzwbIEheHKxZIXjeIlwdiCjdDCyNEB2VSCycnX0doVifGWmIH\vdkA3KGi{czDmc4xtd3enZDDifUBNWFNic4TpcZVt[XSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNC NGrRTpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKxOVI2PSd-M{CyNVUzPTV:L3G+
RAW264.7 NH;uOIRCdnSraX7mcIFudWG2b4L5JIF{e2G7 NYHFdJFZOjBidV2= NGPSe|c3KGi{cx?= NUL6eIRUSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVLXnu[JVk\WRiSVytOkBxem:mdXP0bY9vKGG2IEKwJJVOKHC{ZYTy[YF1\WRiZn;yJFYhcHK|IH\vcIxwf2WmIHL5JGxRWyC|dHnteYxifGmxbjDt[YF{fXKnZDDh[pRmeiB{NDDodpMh[nliRVzJV2E> M33FNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkG1NlU2Lz5|MEKxOVI2PTxxYU6=
RAW264.7 NETrSldCdnSraX7mcIFudWG2b4L5JIF{e2G7 MV6yNEB2VQ>? NHm2TnY3KGi{cx?= MkK1RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhUUxvMXLleIEheHKxZIXjeIlwdiCjdDCyNEB2VSCycnX0doVifGWmIH\vdkA3KGi{czDmc4xtd3enZDDifUBNWFNic4TpcZVt[XSrb36gcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNC M1T4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkG1NlU2Lz5|MEKxOVI2PTxxYU6=
CV1 NFHRUXdHfW6ldHnvckBie3OjeR?= MmfpRYdwdmm|dDDhZ5Rqfmm2eTDheEBz\WOxbXLpcoFvfCCqdX3hckBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hSW[{aXPhckBoemWnbjDtc45s\XliQ2[xJINmdGy|IHL5JG1OXFZibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFAxOc7:TR?= M1iyVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{W5PFE5Lz5|MEO1PVgyQDxxYU6=
RAW264.7 NVvxSJI5SW62aXnu[oxidW2jdH;yfUBie3OjeR?= M3LFWFMxKG2rboO= MkLnRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSoFteGijIIDyc4R2[3Srb36gdJJmfHKnYYTl[EBnd3JiM{CgcYlveyCob3zsc5dm\CCkeTDMVHMhe3SrbYXsZZRqd25iZn;yJFI1KGi{czDifUBGVEmVQTygTWM2OD16LkhOwG0> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODV{OE[5O{c,OzB3Mki2PVc9N2F-
RAW264.7 MWfBcpRqcW6obHHtcYF1d3K7IHHzd4F6 M4\MXVQ5KGi{cx?= NHvkd4JCdnSrLXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iTGDTMYlv\HWlZXSgWG5HNWGucHjhJJBzd2S3Y4Tpc44h[W[2ZYKgOFghcHK|IHL5JGVNUVODLDDJR|UxRTFwMt88US=> NVLwS2plRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C1O|k5ODJpPkOwOVc6QDB{PD;hQi=>
RAW264.7 NVjKSYlUSW62aXnu[oxidW2jdH;yfUBie3OjeR?= NXrncHJGPDhiaILz MXXBcpRqNWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hVFCVLXnu[JVk\WRiSVytOkBxem:mdXP0bY9vKGGodHXyJFQ5KGi{czDifUBGVEmVQTygTWM2OD17LkVOwG0> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODV5OUiwNkc,OzB3N{m4NFI9N2F-
RAW264.7 MXrBcpRqcW6obHHtcYF1d3K7IHHzd4F6 NV7kfXRxOSCqch?= MnSxRY51cS2rbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDOU{Bxem:mdXP0bY9vKHC{ZXnuZ5Vj[XSnZDDmc5IhOSCqcjDmc4xtd3enZDDifUBNWFNvc4TpcZVt[XSrb36gZY5lKG2nYYP1doVlKGGodHXyJFE5KGi{czDifUBIemmnc4OgdoVi\2WwdD3iZZNm\CCjc4PhfUwhUUN3ME2wMlE{|ryP Ml60QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MEi1PFkoRjNyOEC4OVg6RC:jPh?=
RAW264.7 NYK5[|V5SW62aXnu[oxidW2jdH;yfUBie3OjeR?= NVqyOHV3OyCqcoO= NXK5e4lbSW62aT3pcoZt[W2vYYTvdpkh[WO2aY\peJkhcW5ibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBvcXS{aXOgc5hq\GVicILv[JVkfGmxbjDwdoVqdmO3YnH0[YQh\m:{IEOgbJJ{KG[xbHzve4VlKGK7IFzQV{1{fGmvdXzheIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3ME23MlnPxE1? MkP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MUexOVEoRjNyOEG3NVUyRC:jPh?=
Sf9 MXfGeY5kfGmxbjDhd5NigQ>? MmjKNVAhfU1? NGOyXIY1KGi{cx?= MlHISIl{eGyjY3Xt[Y51KG:oIGuzTH0h\GW6YX3leIhie2:wZTDmdo9uKGi3bXHuJJJm[2:vYnnuZY51KEeUIHX4dJJme3OnZDDpckBU\jliaX7z[YN1KGOnbHzzJIF1KDFyIIXNJIlv[3WkYYTl[EBnd3JiNDDodpMh[nlic3PpcpRqdGyjdHnvckBkd3WwdHnu[{Bu\XSqb3S= NFLmWoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEmyPVk1QSd-M{C5Nlk6PDl:L3G+
RAW264.7 M3vnTWFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? MXyzNEBucW6| M13iNGFvfGlvaX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgcol1emmlIH;4bYRmKHC{b3T1Z5Rqd25icILlbY5kfWKjdHXkJIZweiB|MDDtbY5{KG[xbHzve4VlKGK7IFzQV{1{fGmvdXzheIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiMkSgbJJ{KGK7IFfybYV{eyCjc4PhfUwhUUN3ME2wMlAy|ryP M1vrNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUOxOVU6Lz5|MEmzNVU2QTxxYU6=
RAW264.7 M4GyVWFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? M{Cyb|EzKGi{cx?= Mkj5RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKHC{ZXnuZ5Vj[XSnZDDmc5IhOTJiaILzJIZwdGyxd3XkJIJ6KEySUz3zeIlufWyjdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KEe{aXXzd{Bie3OjeTygTWM2OD1zOD60{txO Ml7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFzOEG5NlUoRjNzMUixPVI2RC:jPh?=
RAW264.7 NEDYVoNCdnSraX7mcIFudWG2b4L5JIF{e2G7 MWCxJIhz MlziRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDh[4FqdnO2IFzQV{1qdmS3Y3XkJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVk9ib4\ldpBzd2S3Y4Tpc44heHKnaX7jeYJifGWmIH\vdkAyKGi{IIDybY9zKHSxIFXzZ4hmemmlaHnhJINwdGliTGDTJJN1cW23bHH0bY9vKG[xbHzve4VlKGK7IH\1dpRp\XJiaX7jeYJifGmxbjDmc5IhOjRiaILzJIJ6KEe{aXXzd{Bz\WGpZX70JIJie2WmIIPw[YN1em:yaH;0c41mNCCLQ{WwQVUvODMQvF2= NXno[JBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOlA5QTJpPkOxNlYxQDl{PD;hQi=>
RAW264.7 M4fpbmFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NUm0OmJrOTBidV2= M3vyR|EhcHK| MXXBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHHnZYlve3RibX;1d4UhWkGZMk[0Mlch[2WubIOgZZN{\XO|ZXSgZZMh\G:5boLl[5Vt[XSrb36gc4YhVFCVLYP0bY12dGG2ZXSgbW5QWyCycn;0[YlvKGW6cILld5Nqd25iYYSgNVAhfU1icILleJJm[XSnZDDmc5IhOSCqcoOg[o9tdG:5ZXSgZpkhVFCVIHHk[Il1cW:wIHHu[EBu\WG|dYLl[EBi\nSncjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NFXTN4U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOwNVU3Pid-M{GzNFE2PjZ:L3G+
RAW264.7 NEHrfVNCdnSraX7mcIFudWG2b4L5JIF{e2G7 NGDDPWsyOCC3TR?= MUOxJIhzew>? NVPVVINmSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHTve45z\We3bHH0bY9vKG:oIFzQV{1{fGmvdXzheIVlKEORWEKgdJJwfGWrbjDlfJBz\XO|aX;uJIF1KDFyIIXNJJBz\XS{ZXH0[YQh\m:{IEGgbJJ{KG[xbHzve4VlKGK7IFzQV{Bi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NIfXZ5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUOwNVU3Pid-M{GzNFE2PjZ:L3G+
RAW264.7 Mn7LRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NXHUOWt3OSCqch?= NXfScIR5SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfGm{YzDvfIll\SCycn;keYN1cW:wIIDy[Ylv[3WkYYTl[EBnd3JiMTDodkBnd2yub4fl[EBjgSCOUGOtd5RqdXWuYYTpc44h[W6mIH3lZZN2emWmIHHmeIVzKDF6IHjyd{BjgSCJcnnld5Mh[XO|YYmsJGlEPTB;MD6wNe69VQ>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTNyMUmzNEc,OzF|MEG5N|A9N2F-
RAW264.7 MnXsRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? M2LKc|I2PC56IIXN MYqyOEBpenN? NIrXTpJCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hVFCVLXnu[JVk\WRiTl:gdJJw\HWldHnvckBifCB{NUSuPEB2VSCvZXHzeZJm\CCjZoTldkAzPCCqcoOgZpkh\3KrZYPzJJJm[WenboSgZoF{\WRiYYPzZZk> NWjQdZVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0OlUzOThpPkOxOFY2OjF6PD;hQi=>
LO2 NFTzd4RHfW6ldHnvckBie3OjeR?= NFvMeVkxNjJ3IIXN NFHVb4MzPCCqcoO= NEflNmtC\2:waYP0JIFkfGm4aYT5JIF1KE[[UjDpckBofWepdXzzeIVzd26nLYTy[YF1\WRiaIXtZY4hVE9{IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGJUTVBibWLORUBmgHC{ZYPzbY9vKGG2IECuNlUhfU1idILlZZRm\CC5aYToJGZZWiCjboTh[49vcXO2LDDneYdofWy|dHXyc45mKG[xcjCyOEBpenNiZn;scI94\WRiYomgbY5kfWKjdHnvckB4cXSqIHPvcZBwfW6mIH\vdkAzPCCqcoOgZpkhWlRvcWDDVkBidmGueYPpdy=> NF32eG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUS5OFQ4OCd-M{G0PVQ1PzB:L3G+
LO2 M2DE[WZ2dmO2aX;uJIF{e2G7 NUDQbWp5OC5{NTD1US=> MmPGNlQhcHK| NYW0Z3pMSWexbnnzeEBi[3Srdnn0fUBifCCIWGKgbY4h\3WpZ4Xsd5Rmem:wZT30doVifGWmIHj1cYFvKEyRMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBWT1R{QUSgcXJPSSCneIDy[ZN{cW:wIHH0JFAvOjVidV2geJJm[XSnZDD3bZRpKE[[UjDhcpRi\2:waYP0MEBofWepdXzzeIVzd26nIH\vdkAzPCCqcoOg[o9tdG:5ZXSgZpkhcW6ldXLheIlwdiC5aYToJINwdXCxdX7kJIZweiB{NDDodpMh[nliUmStdXBEWiCjbnHsfZNqew>? NYfm[YI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0PVQ1PzBpPkOxOFk1PDdyPD;hQi=>
LO2 NXG0XopFTnWwY4Tpc44h[XO|YYm= MWqwMlI2KHWP MnfvNlQhcHK| MXHVdJJm\3WuYYTpc44hd2ZiRmjSJJBzd3SnaX6g[ZhxemW|c3nvckBqdiCqdX3hckBNVzJiY3XscJMh[XRiMD6yOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NInCUJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUS5OFQ4OCd-M{G0PVQ1PzB:L3G+
LO2 M{DpXWZ2dmO2aX;uJIF{e2G7 MWiwMlI2KHWP MVKyOEBpenN? MYXB[49vcXO2IHHjeIl3cXS7IHH0JGZZWiCrbjDoeY1idiCOT{KgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hW0iSMTDwdo91\WmwIHX4dJJme3Orb36gZZQhOC5{NTD1UUBi\nSncjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ NUnwNnVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0PVQ1PzBpPkOxOFk1PDdyPD;hQi=>
LO2 MUnGeY5kfGmxbjDhd5NigQ>? MX[wMlI2KHWP NWr1VWZ6OjRiaILz NEnTbmlC\2:waYP0JIFkfGm4aYT5JIF1KE[[UjDpckBpfW2jbjDMU|Ih[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iQmPFVEBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiMD6yOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| M4TReFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEm0OFcxLz5|MUS5OFQ4ODxxYU6=
LO2 NGjGN5dHfW6ldHnvckBie3OjeR?= MlfZNE4zPSC3TR?= Mn2xNlQhcHK| NEnmRXZC\2:waYP0JIFkfGm4aYT5JIF1KE[[UjDpckBpfW2jbjDMU|Ih[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTWLQNkBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiMD6yOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NILDWpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUS5OFQ4OCd-M{G0PVQ1PzB:L3G+
LO2 M1vRdmZ2dmO2aX;uJIF{e2G7 NVXIXI9WOC5{NTD1US=> Ml24NlQhcHK| Mni5RYdwdmm|dDDhZ5Rqfmm2eTDheEBHYFJiaX6gbJVu[W5iTF:yJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKFOXTGSyRUBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiMD6yOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NH7WbHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUS5OFQ4OCd-M{G0PVQ1PzB:L3G+
LO2 Ml3VSpVv[3Srb36gZZN{[Xl? MYGwMlI2KHWP M2HB[VI1KGi{cx?= MoDoRYdwdmm|dDDhZ5Rqfmm2eTDheEBHYFJiaX6gbJVu[W5iTF:yJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEO\UEfBNUBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiMD6yOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MkTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2OUS0O|AoRjNzNEm0OFcxRC:jPh?=
LO2 NEHsfoVHfW6ldHnvckBie3OjeR?= NETEOmExNjJ3IIXN M1L0[FI1KGi{cx?= MlnORYdwdmm|dDDhZ5Rqfmm2eTDheEBHYFJiaX6gbJVu[W5iTF:yJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEO\UEjCNUBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiMD6yOUB2VSCjZoTldkAzPCCqcoOgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| M3;P[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNEm0OFcxLz5|MUS5OFQ4ODxxYU6=
LO2 MY\GeY5kfGmxbjDhd5NigQ>? M2\uZVAvOjVidV2= M1e5dlI1KGi{cx?= MmjlRYdwdmm|dDDhZ5Rqfmm2eTDheEBHYFJiaX6gbJVu[W5iTF:yJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKE6WQ2CgdJJwfGWrbjDlfJBz\XO|aX;uJIF1KDBwMkWgeW0h[W[2ZYKgNlQhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTR7NES3NEc,OzF2OUS0O|A9N2F-
RAW264.7 M{HFUGFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? MY[yOEBpenN? M3\mTGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKE6RIIDyc4R2[3Srb36gbY5kfWKjdHXkJIZweiB{NDDodpMh[nliR4Lp[ZN{KHKnYXflcpQu[mG|ZXSgZZN{[XluIFnDOVA:Ps7:TR?= NYLDbGY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1O|c1OzRpPkOxOVc4PDN2PD;hQi=>
RAW264.7 M1j2O2FvfGmrbn\sZY1u[XSxcomgZZN{[Xl? NYewdFhIOjRiaILz NYXxUlZwSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVLXnu[JVk\WRiVF7GMYFteGijIIPlZ5JmfGmxbjDh[pRmeiB{NDDodpMh[nliRVzJV2EtKEmFNUC9Ok4y|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV5N{SzOEc,OzF3N{e0N|Q9N2F-
RAW264.7 M4rMZWFvfGmrbn\sZY1u[XSxcomgZZN{[Xl? MYeyOEBpenN? NInTT|hCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCLTD22JJNm[3KndHnvckBi\nSncjCyOEBpenNiYomgSWxKW0FuIFnDOVA:QC52zszN M1\GU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUe3OFM1Lz5|MUW3O|Q{PDxxYU6=
THP1 NH;ZOnRCdnSraX7mcIFudWG2b4L5JIF{e2G7 MnjMNlAxKHWP Ml;1OEBpenN? M3K0eGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWSGCxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckBifCB{MECgeW0heHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBNWFNiY3jhcIxmdmenIHHu[EBu\WG|dYLl[EBi\nSncjCyOEBpenNiaX7jeYJifGmxbjDifUBGVEmVQR?= NYTFeoIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G4NFQ5OzBpPkOxPFA1QDNyPD;hQi=>
RAW264.7 Mo\KRY51cWmwZnzhcY1ifG:{eTDhd5NigQ>? NGHzbJVCdnSrLXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHzpdI9xd2y7c3HjZ4hiemmmZT3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vNCCLQ{WwQVUvPc7:TR?= Mn[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF6N{OwNVQoRjNzOEezNFE1RC:jPh?=
RPMI18226 MmHtRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIHOe3g4OiCqcoO= NEHBcXBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLQUWkyQDJ{NjDj[YxteyCjZoTldkA4OiCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwQVAvODB5ON88US=> NETMV3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw{QDR2NkevK|5EcEWPQly8M4E,
RAW264.7 NGPofHlCdnSraX7mcIFudWG2b4L5JIF{e2G7 MUGyJIhzew>? NW[wb3hJSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJG5QKHC{b3T1Z5Rqd25icILleJJm[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhVFCVIIP0bY12dGG2aX;uJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDHdolme3NiYYPzZZktKEmFNUC9Nk43Ps7:TR?= NVXwSWlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOzh2NE[3M{c,S2iHTVLMQE9iRg>?
A549 MlzrSpVv[3Srb36gZZN{[Xl? M3r0UFEhfU1? MUm0PEBpenN? MVXEc5dvemWpdXzheIlwdiCxZjDEUmEhemWybHnjZZRqd25iaX6gbJVu[W5iQUW0PUBk\WyuczDheEAyKHWPIHHmeIVzKDR6IHjyd{BjgSCXVj32bZNq[mynIIPw[YN1em:yaH;0c41mfHKrYzDhcoFtgXOrcx?= MkHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMN|g1PDZ5Lze+R4hGVUKOPD;hQi=>
U2OS NXHMdVE3TnWwY4Tpc44h[XO|YYm= M3fhTFAvOSC3TR?= MYKyOEBpenN? M3PlWGFkfGm4YYTpc44hd2ZiZ3z1cINw[2:{dHnjc4llKHKnY3XweI9zKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKFV{T2OgZ4VtdHNiYYSgNE4yKHWPIHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= M3zU[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFM5PDR4Nz:nQmNpTU2ETEyvZV4>
Assay
Methods Test Index PMID
Western blot p-AKT / AKT ; GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP ; BCRP / P-gp / Mrp2 29436611 24691439 18524938
Immunofluorescence GRP78 24691439
Growth inhibition assay Cell viability 22719835
In vivo Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]

Protocol (from reference)

Animal Research:[5]
  • Animal Models: Sprague-Dawley rats
  • Dosages: 100 μg/kg
  • Administration: Intraperitoneal injection

Solubility (25°C)

In vitro

Water 103 mg/mL
(199.45 mM)
DMSO Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 516.4
Formula

C22H30FO8P.2Na

CAS No. 55203-24-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05142098 Not yet recruiting Drug: Dexamethasone|Drug: Etoricoxib 60 mg Effect of Drug Dow University of Health Sciences January 1 2022 Early Phase 1
NCT05170789 Not yet recruiting Drug: Elotuzumab Selinexor and Dexamethasone (ESd) Relapsed Multiple Myeloma|Refractory Multiple Myeloma Tulane University School of Medicine|Karyopharm Therapeutics Inc|Tulane University January 7 2022 Phase 2
NCT05136781 Recruiting -- Thoracic Surgery|Anesthesiology|Corticosteroids|Respiratory Complication Centre Hospitalier Universitaire Amiens November 16 2021 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Dexamethasone Sodium Phosphate | Dexamethasone Sodium Phosphate supplier | purchase Dexamethasone Sodium Phosphate | Dexamethasone Sodium Phosphate cost | Dexamethasone Sodium Phosphate manufacturer | order Dexamethasone Sodium Phosphate | Dexamethasone Sodium Phosphate distributor