Dexamethasone Sodium Phosphate

For research use only.

Catalog No.S4028 Synonyms: Dexamethasone 21-phosphate disodium salt

22 publications

Dexamethasone Sodium Phosphate Chemical Structure

CAS No. 55203-24-2

Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Selleck's Dexamethasone Sodium Phosphate has been cited by 22 publications

Purity & Quality Control

Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Features Great selectivity for COX-2.
Targets
IL receptor [6] COX-2 [1]
In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT ; 

PubMed: 29436611     


Dexamethasone (C) promoted Akt phosphorylation in PC3 cells and inhibited Akt phosphorylation in PC3-AR9.

GRP78 / GRP94 / pIREα / IREα / peIF2α / eIF2α CHOP ; 

PubMed: 24691439     


Dexamethasone induced ER stress and activated the UPR in human TM cells. Primary human TM cells obtained from normal human donors were treated with dexamethasone for 48 hours. GRP78, GRP94, CHOP, and phosphorylation of IRE1 and eIF2α were examined by Western blot analysis (n = 3).

BCRP / P-gp / Mrp2 ; 

PubMed: 18524938     


Dexamethasone induced bcrp, p-glycoprotein (p-gp), and mrp2 protein expression in brain endothelial cells. A: representative Western blots demonstrating the concentration-dependent increase in protein expression of bcrp, p-gp, and mrp2 in primary endothelial cells when cultured with dexamethasone for 24 h. Quantitative analysis by densitometry of three different experiments is also shown. B: dexamethasone-induced increase in bcrp, p-gp, and mrp2 expression after incubation of endothelial cells with 250 nM dexamethasone was dependent on the time of exposure. Quantitative analysis by densitometry of three different experiments is also shown. *P < 0.05 vs. untreated cells, **P < 0.01 vs. untreated cells.

29436611 24691439 18524938
Immunofluorescence
GRP78; 

PubMed: 24691439     


Human TM cells were treated with vehicle or dexamethasone for 48 hours and stained with GRP78 and phalloidin (which stains F-actin) (n = 3). Dexamethasone treatment increased actin and GRP78 levels. Scale bars: 50 μm.

24691439
Growth inhibition assay
Cell viability; 

PubMed: 22719835     


(A) Proliferation of MC3T3-E1 cells was measured by CCK8 (colorimetric cell counting kit-8) after cells were treated with 0, 0.001,0.01,0.1, 1.0 and 10.0 µmol/L dexamethasone for 24 hours. treatment with 1 and 10 µmol/L DEX remarkably reduced cell proliferation. B) Cell death was measured by typan blue incorporation after cells were treated with 0, 0.001,0.01,0.1, 1.0 and 10.0 µmol/L dexamethasone for 24 hours. treatment with 1 and 10 µmol/L dexamethasone remarkably increased dead cell population Values are means+SEM (n = 3). *P< 0.05 vs corresponding untreated controls.

22719835
In vivo Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]

Protocol

Animal Research:[5]
- Collapse
  • Animal Models: Sprague-Dawley rats
  • Dosages: 100 μg/kg
  • Administration: Intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro Water 103 mg/mL (199.45 mM)
DMSO Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 516.4
Formula

C22H30FO8P.2Na

CAS No. 55203-24-2
Storage powder
in solvent
Synonyms Dexamethasone 21-phosphate disodium salt
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04911361 Not yet recruiting Drug: Dexamethasone Dry Eye Research Insight LLC July 26 2021 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID