Pepstatin A

For research use only.

Catalog No.S7381 Synonyms: Pepstatin

16 publications

Pepstatin A Chemical Structure

CAS No. 26305-03-3

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.

Selleck's Pepstatin A has been cited by 16 publications

Purity & Quality Control

Choose Selective HIV Protease Inhibitors

Biological Activity

Description Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
Targets
aspartic protease [1]
()
cathepsins D [2]
()
cathepsins E [2]
()
In vitro

Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, pepstatin A inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. [1] Pepstatin A laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-231 MUDGeY5kfGmxbjDhd5NigQ>? NVT2[4VlOyCmYYnz M1q0b2lvcGmkaYTpc44hd2Zic3XjdoV1\WRiY3H0bIVxe2mwIFSgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczD1d4lv\yCPY3GtS4x6NUy7cz3Qdo8uUWynLVzleU1RcGWSaHWtRZJoNUyndT3MfZMuMESwcDmtSE1CemdvTliyJIF{KHO3YoP0doF1\SCycnX0doVifGWmIH\vdkA{KGSjeYOgeY5l\XJicFigOk43KGOxbnTpeIlwdmWmIH3l[IliKG[xbHzve4VlKGK7IIP1ZpN1emG2ZTDh[IRqfGmxbjDt[YF{fXKnZDDheEA2KG2rboOgbY51\XK4YXyg[o9zKCxiSVO1NF0xNjByMEJOwG0v MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB6N{exNkc,OjlyOEe3NVI9N2F-
MDA-MB-231 M1H6PWZ2dmO2aX;uJIF{e2G7 MlywN{Bl[Xm| NV7QS2FzUW6qaXLpeIlwdiCxZjDz[YNz\XSnZDDjZZRp\XC|aX6gSUBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJJV{cW6pIF3jZU1IdHlvTInzMXBzdy2LbHWtUIV2NVCqZWDo[U1CemdvTHX1MWx6ey1qRH7wLU1FNUG{Zz3OTFIh[XNic4Xid5Rz[XSnIIDy[ZRz\WG2ZXSg[o9zKDNiZHH5d{B2dmSncjDwTEA3NjZiY3;u[Il1cW:wZXSgcYVlcWFiZn;scI94\WRiYomgd5Vje3S{YYTlJIFl\Gm2aX;uJI1m[XO3cnXkJIF1KDVibXnud{BqdnSnco\hcEBnd3JiLDDJR|UxRTBwMECwNe69VS5? MkfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEe3NVIoRjJ7MEi3O|EzRC:jPh?=
MCF7 M{DtcmZ2dmO2aX;uJIF{e2G7 M3;qTGlvcGmkaYTpc44hd2ZiY3H0bIVxe2mwIFSgbY4hcHWvYX6gUWNHPyClZXzsd{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:OC5yMEZOwG0v M{nqeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{G1N|IxLz5zOUexOVMzODxxYU6=
MCF7 NHT3THFHfW6ldHnvckBie3OjeR?= NEjNVGZKdmirYnn0bY9vKG:oIHPheIhmeHOrbjDFJIlvKGi3bXHuJG1ETjdiY3XscJMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwMEC1{txONg>? NVzMOWpRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NVU{OjBpPkG5O|E2OzJyPD;hQi=>
MDA-MB-231 Moq0SpVv[3Srb36gZZN{[Xl? MnPQOEBpenN? MoWwTY5pcWKrdHnvckBw\iClYYTo[ZB{cW5iRDDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IIXzbY5oKE2lYT3HcJkuVHm|LWDyc{1KdGVvTHX1MXBp\VCqZT3BdocuVGW3LVz5d{0pTG6yKT3EMWFz\y2QSEKgZZMhe3Wkc4TyZZRmKHC{ZYTy[YF1\WRiZn;yJFQhcHK|IH\vcIxwf2WmIHL5JINwdXCxdX7kJJdie2ixdYSgZY5lKHO3YoPldZVmdnRic4Xid5Rz[XSnIHHk[Il1cW:wIH3lZZN2emWmIHH0JFMxKHOnY4OgbY51\XK4YXyg[o9zKDNyIH3pcpMhNCCLQ{WwQVAvOc7:TT6= Ml\ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEe3NVIoRjJ7MEi3O|EzRC:jPh?=
MDA-MB-231 MWjGeY5kfGmxbjDhd5NigQ>? NELWUHU1KGi{cx?= MXrJcohq[mm2aX;uJI9nKGOjdHjldJNqdiCHIHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNidYPpcochVWOjLVfsfU1NgXNvUILvMWlt\S2OZYWtVIhmWGinLVHy[{1N\XVvTInzMUhFdnBrLVStRZJoNU6KMjDhd{B{fWK|dILheIUheHKndILlZZRm\CCob4KgOEBpenNiZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDhcoQhe3Wkc3XxeYVvfCC|dXLzeJJifGViYXTkbZRqd25ibXXhd5Vz\WRiYYSgN|Ahe2WlczDpcpRmen[jbDDmc5IhOzBibXnud{AtKEmFNUC9NE4y|ryPLh?= NH;0VWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4O|cyOid-MkmwPFc4OTJ:L3G+
MDA-MB-231 M3jHUmZ2dmO2aX;uJIF{e2G7 M{XF[FQhcHK| MkfITY5pcWKrdHnvckBw\iClYYTo[ZB{cW5iRDDpckBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IIXzbY5oKE2lYT3HcJkuVHm|LWDyc{1KdGVvTHX1MXBp\VCqZT3BdocuVGW3LVz5d{0pTG6yKT3EMWFz\y2QSEKgZZMhe3Wkc4TyZZRmKHC{ZYTy[YF1\WRiZn;yJFQhcHK|IH\vcIxwf2WmIHL5JINwdXCxdX7kJJdie2ixdYSgZY5lKHO3YoPldZVmdnRiMUCgcYlveyC2conwd4lvcXqjdHnvckBxemmxcjD0c{B{fWK|dILheIUh[WSmaYTpc44hdWWjc4Xy[YQhNCCLQ{WwQVHPxE1w MkT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEe3NVIoRjJ7MEi3O|EzRC:jPh?=
MDA-MB-231 MUfGeY5kfGmxbjDhd5NigQ>? M{e5SlQhcHK| MV3Jcohq[mm2aX;uJI9nKGOjdHjldJNqdiCHIHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNidYPpcochVWOjLVfsfU1NgXNvUILvMWlt\S2OZYWtVIhmWGinLVHy[{1N\XVvTInzMUhFdnBrLVStRZJoNU6KMjDhd{B{fWK|dILheIUheHKndILlZZRm\CCob4KgOEBpenNiZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDhcoQhe3Wkc3XxeYVvfCBzMDDtbY5{KHS{eYDzbY5qgmG2aX;uJJBzcW:{IITvJJN2[nO2cnH0[UBi\GSrdHnvckBu\WG|dYLl[EAtKEmFNUC9Ne69VS5? M37GdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi3O|EzLz5{OUC4O|cyOjxxYU6=
MCF7 MkjVSpVv[3Srb36gZZN{[Xl? Mmm2NUBpeg>? M2r6XmlvcGmkaYTpc44hd2ZiY3H0bIVxe2mwIFSgbY4hcHWvYX6gUWNHPyClZXzsd{B1emWjdHXkJIZweiBzIHjyJI1m[XO3cnXkJIFnfGW{IIfhd4hwfXRiYX7kJJRzgXC|aX6geJJm[XSvZX70JIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NF02|ryPLh?= NHfjXm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUexOVMzOCd-MUm3NVU{OjB:L3G+
MCF7 NEC3UJpHfW6ldHnvckBie3OjeR?= NHewOXcyKGi{ MmrITY5pcWKrdHnvckBw\iClYYTo[ZB{cW5iRTDpckBpfW2jbjDNR2Y4KGOnbHzzJJRz\WG2ZXSg[o9zKDFiaIKgcYVie3W{ZXSgZYZ1\XJid3HzbI92fCCjbnSgeJJ6eHOrbjD0doVifG2nboSgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVXPxE1w M1\5dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{G1N|IxLz5zOUexOVMzODxxYU6=
NB1643 MXTxTHRUKGG|c3H5 NHf6WZZyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBPSjF4NEOgZ4VtdHN? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
A673 MXzxTHRUKGG|c3H5 M3j4b5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGE3PzNiY3XscJMq MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-MC MYPxTHRUKGG|c3H5 MWrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNU2FIHPlcIx{ MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
TC32 MWLxTHRUKGG|c3H5 NUTVRnFleUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? NVPpXW96RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (83.1 mM)
Ethanol 1 mg/mL warmed (1.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 685.89
Formula

C34H63N5O9

CAS No. 26305-03-3
Storage powder
in solvent
Synonyms Pepstatin
Smiles CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Do you have recommended in-vivo solvent for S7381 please?

  • Answer:

    S7681 could be dissolved in 5%DMSO+40%PEG300+tween-80+ddH2O up to 2mg/ml.

HIV Protease Signaling Pathway Map

Related HIV Protease Products

Tags: buy Pepstatin A | Pepstatin A supplier | purchase Pepstatin A | Pepstatin A cost | Pepstatin A manufacturer | order Pepstatin A | Pepstatin A distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID