Pepstatin A

For research use only.

Catalog No.S7381 Synonyms: Pepstatin

11 publications

Pepstatin A Chemical Structure

CAS No. 26305-03-3

Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.

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Selleck's Pepstatin A has been cited by 11 publications

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Biological Activity

Description Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases.
Targets
aspartic protease [1]
()
cathepsins D [2]
()
cathepsins E [2]
()
In vitro

Pepstatin A shows effective inhibition on aspartic proteinases such as pepsin, cathepsins D and E. In HIV-infected H9 cells, pepstatin A inhibits part of the intracellular processing of the HIV gag protein with no apparent toxicity on HIV-infected cells. [1] Pepstatin A laos suppresses the differentiation of osteoclasts by blocking ERK signaling and the inhibition of NFATc1 expression. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA-MB-231 NFrCRpFHfW6ldHnvckBie3OjeR?= NIPxN|Y{KGSjeYO= NXTOSZFRUW6qaXLpeIlwdiCxZjDz[YNz\XSnZDDjZZRp\XC|aX6gSEBqdiCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJJV{cW6pIF3jZU1IdHlvTInzMXBzdy2LbHWtUIV2NVCqZWDo[U1CemdvTHX1MWx6ey1qRH7wLU1FNUG{Zz3OTFIh[XNic4Xid5Rz[XSnIIDy[ZRz\WG2ZXSg[o9zKDNiZHH5d{B2dmSncjDwTEA3NjZiY3;u[Il1cW:wZXSgcYVlcWFiZn;scI94\WRiYomgd5Vje3S{YYTlJIFl\Gm2aX;uJI1m[XO3cnXkJIF1KDVibXnud{BqdnSnco\hcEBnd3JiLDDJR|UxRTBwMECwNe69VS5? NGLC[HU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4O|cyOid-MkmwPFc4OTJ:L3G+
MDA-MB-231 NFnCfmRHfW6ldHnvckBie3OjeR?= M2TYeVMh\GG7cx?= MYXJcohq[mm2aX;uJI9nKHOnY4LleIVlKGOjdHjldJNqdiCHIHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNidYPpcochVWOjLVfsfU1NgXNvUILvMWlt\S2OZYWtVIhmWGinLVHy[{1N\XVvTInzMUhFdnBrLVStRZJoNU6KMjDhd{B{fWK|dILheIUheHKndILlZZRm\CCob4KgN{Bl[Xm|IIXu[IVzKHCKIE[uOkBkd26maYTpc45m\CCvZXTpZUBnd2yub4fl[EBjgSC|dXLzeJJifGViYXTkbZRqd25ibXXhd5Vz\WRiYYSgOUBucW6|IHnueIVzfmGuIH\vdkAtKEmFNUC9NE4xODBzzszNMi=> M3PEOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi3O|EzLz5{OUC4O|cyOjxxYU6=
MCF7 Mm\sSpVv[3Srb36gZZN{[Xl? NHniTHlKdmirYnn0bY9vKG:oIHPheIhmeHOrbjDEJIlvKGi3bXHuJG1ETjdiY3XscJMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwMEC1{txONg>? NW[4[|dlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NVU{OjBpPkG5O|E2OzJyPD;hQi=>
MCF7 NFH0cpRHfW6ldHnvckBie3OjeR?= NEPqRlRKdmirYnn0bY9vKG:oIHPheIhmeHOrbjDFJIlvKGi3bXHuJG1ETjdiY3XscJMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwMEC1{txONg>? NWTSU2RKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NVU{OjBpPkG5O|E2OzJyPD;hQi=>
MDA-MB-231 NEC1d49HfW6ldHnvckBie3OjeR?= Mki0OEBpenN? M3L6U2lvcGmkaYTpc44hd2ZiY3H0bIVxe2mwIFSgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczD1d4lv\yCPY3GtS4x6NUy7cz3Qdo8uUWynLVzleU1RcGWSaHWtRZJoNUyndT3MfZMuMESwcDmtSE1CemdvTliyJIF{KHO3YoP0doF1\SCycnX0doVifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBkd22yb4Xu[EB4[XOqb4X0JIFv\CC|dXLz[ZF2\W62IIP1ZpN1emG2ZTDh[IRqfGmxbjDt[YF{fXKnZDDheEA{OCC|ZXPzJIlvfGW{dnHsJIZweiB|MDDtbY5{KCxiSVO1NF0xNjIQvF2u M2LlSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi3O|EzLz5{OUC4O|cyOjxxYU6=
MDA-MB-231 NWq2cGNETnWwY4Tpc44h[XO|YYm= NHv5Nlg1KGi{cx?= NHLORWpKdmirYnn0bY9vKG:oIHPheIhmeHOrbjDFJIlvKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgeZNqdmdiTXPhMWdtgS2OeYOtVJJwNUmuZT3M[ZUuWGinUHjlMWFz\y2OZYWtUJl{NSiGboCpMWQuSXKpLV7INkBieyC|dXLzeJJifGVicILleJJm[XSnZDDmc5IhPCCqcoOg[o9tdG:5ZXSgZpkh[2:vcH;1coQhf2G|aH;1eEBidmRic4Xid4VyfWWwdDDzeYJ{fHKjdHWgZYRlcXSrb36gcYVie3W{ZXSgZZQhOzBic3Xjd{BqdnSnco\hcEBnd3JiM{CgcYlveyBuIFnDOVA:OC5zzszNMi=> MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB6N{exNkc,OjlyOEe3NVI9N2F-
MDA-MB-231 MVnGeY5kfGmxbjDhd5NigQ>? NIX5SXA1KGi{cx?= MYHJcohq[mm2aX;uJI9nKGOjdHjldJNqdiCGIHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNidYPpcochVWOjLVfsfU1NgXNvUILvMWlt\S2OZYWtVIhmWGinLVHy[{1N\XVvTInzMUhFdnBrLVStRZJoNU6KMjDhd{B{fWK|dILheIUheHKndILlZZRm\CCob4KgOEBpenNiZn;scI94\WRiYomgZ49ueG:3bnSge4F{cG:3dDDhcoQhe3Wkc3XxeYVvfCBzMDDtbY5{KHS{eYDzbY5qgmG2aX;uJJBzcW:{IITvJJN2[nO2cnH0[UBi\GSrdHnvckBu\WG|dYLl[EAtKEmFNUC9Ne69VS5? NHHMZpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUC4O|cyOid-MkmwPFc4OTJ:L3G+
MDA-MB-231 MUDGeY5kfGmxbjDhd5NigQ>? Mn\jOEBpenN? M2LveGlvcGmkaYTpc44hd2ZiY3H0bIVxe2mwIFWgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczD1d4lv\yCPY3GtS4x6NUy7cz3Qdo8uUWynLVzleU1RcGWSaHWtRZJoNUyndT3MfZMuMESwcDmtSE1CemdvTliyJIF{KHO3YoP0doF1\SCycnX0doVifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBkd22yb4Xu[EB4[XOqb4X0JIFv\CC|dXLz[ZF2\W62IEGwJI1qdnNidIL5dJNqdmm8YYTpc44heHKrb4KgeI8he3Wkc4TyZZRmKGGmZHn0bY9vKG2nYYP1doVlKCxiSVO1NF0y|ryPLh?= M1zZRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MEi3O|EzLz5{OUC4O|cyOjxxYU6=
MCF7 NYPtdVUxTnWwY4Tpc44h[XO|YYm= M3fSbVEhcHJ? NULUZoFtUW6qaXLpeIlwdiCxZjDjZZRp\XC|aX6gSEBqdiCqdX3hckBOS0Z5IHPlcIx{KHS{ZXH0[YQh\m:{IEGgbJIhdWWjc4Xy[YQh[W[2ZYKge4F{cG:3dDDhcoQhfHK7cIPpckB1emWjdH3lcpQh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTYQvF2u NYTkOZQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NVU{OjBpPkG5O|E2OzJyPD;hQi=>
MCF7 NHezfo9HfW6ldHnvckBie3OjeR?= M3nYSlEhcHJ? NEC5[WtKdmirYnn0bY9vKG:oIHPheIhmeHOrbjDFJIlvKGi3bXHuJG1ETjdiY3XscJMhfHKnYYTl[EBnd3JiMTDodkBu\WG|dYLl[EBi\nSncjD3ZZNpd3W2IHHu[EB1enmyc3nuJJRz\WG2bXXueEBjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:Pc7:TT6= M1WwOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{G1N|IxLz5zOUexOVMzODxxYU6=
NB1643 MU\xTHRUKGG|c3H5 MmH2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUmIyPjR|IHPlcIx{ M1z1ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
A673 MXnxTHRUKGG|c3H5 M4W3VZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGE3PzNiY3XscJMq MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-MC NF7yWIpyUFSVIHHzd4F6 MVnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDTT{1PNU2FIHPlcIx{ M1\5PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
TC32 M2Xxb5FJXFNiYYPzZZk> MkexdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgWGM{OiClZXzsdy=> NIXIS2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+

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Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (83.1 mM)
Ethanol 1 mg/mL warmed (1.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 685.89
Formula

C34H63N5O9

CAS No. 26305-03-3
Storage powder
in solvent
Synonyms Pepstatin
Smiles CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    Do you have recommended in-vivo solvent for S7381 please?

  • Answer:

    S7681 could be dissolved in 5%DMSO+40%PEG300+tween-80+ddH2O up to 2mg/ml.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID