Idelalisib (CAL-101, GS-1101)

Catalog No.S2226

Idelalisib (CAL-101, GS-1101) Chemical Structure

Molecular Weight(MW): 415.42

Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

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Cited by 38 Publications

6 Customer Reviews

  • Invasive migration of RA FLS was analyzed through growth factor–reduced Matrigel-coated transwell inserts in the presence or absence of 1 µM INK007, 5 µM CAL-101, or 0.3 µM IPI-145, or 0.3 µM GDC-0941 inhibitors or DMSO. Cells were allowed to invade through Matrigel toward PDGF-BB (25 ng/ml) containing media for 24 h and were fixed and stained with Hemacolor staining kit.

    J Immunol, 2014, 192(5): 2063-70 . Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    Ppp2r1afl/fl BCR-ABL1 B-ALL cells transduced with 4-OHT-inducible Cre-ERT2 (Cre) or ERT2-vector (EV) were treated with 4-OHT for 3 days and cell lysates were studied by phospho-protein array analysis. Ppp2r1afl/fl BCR-ABL1 ALL cells were transduced with 4-OHT-inducible Cre or EV control and incubated in the presence of the small molecule signaling inhibitor idelalisib (32 μmol/L; C). Percentages of GFP+ cells were measured by flow cytometry at the times indicated following 4-OHT-treatment. Data are shown as mean ± standard deviation (SD) and representative of at least three independent experiments.

    Cell, 2018, 173(2):470-484. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

  • Rolling and sticking fractions of calcein-labeled CLL cells from a patient with bulky disease are shown before treatment, and at 3 or 7 weeks under idelalisib treatment. Mean ± SD, venular order III (n = 3), order IV (n = 4), order V (n = 3-4). Unpaired t test; *P < .05, **P < .01.

    Blood, 2016, 127(25):3192-201. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    293T cells were transfected with HA-tagged Fbxo45. At 48 h after transfection, cells were treated with AKT inhibitor (CAL-101; 10 uM, 4 h), cell extracts from the cytoplasm or nuclei were subjected to IP with anti-HA resin followed by western blot analysis with indicated antibodies.

    Cell Death Differ 2014 21(10), 1535-45. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

  • Isoform-selective PI3K inhibitors blocked PI3K signaling in corresponding Rh30-Myr-p110 cells. Rh30-Myr-p110s cells were cultured in serum-free medium for 12 h, and then exposed to CAL-101 at indicated concentrations for additional 1 h. The cells were collected to detect the level of phosphorylated and total Akt. β-Actin was served as loading control.

    Acta Pharmacol Sin 2013 34(9),1201-7. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

    After starved in serum-free medium for 24 h,A549 cells incubated with the indicated concentrations of CAL-101 for 3 h,followed by 20-minute stimolation of 100ng/ml EGF.

    Dr. Zhang of Tianjin Medical University. Idelalisib (CAL-101, GS-1101) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Targets
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
In vitro

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 M1n6U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnIfZBTTE2VTx?= M2joUGlEPTB;MkCuOEDPxE1? M1LINFI2QTl7M{Wy
CLL PBMCs MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnlZnd{TE2VTx?= M4fyTWlEPTB;Mj65JI5O NUDSfW1iOjV7MUeyOlc>
U266 NFLtVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWm0NEDPxE1? NIXBVGM1QCCq NVH6eVhMPzlwNTWgbY5pcWKrdHnvckBz[XSn MYGyOVM{QTN|Mh?=
K562 MYTGeY5kfGmxbjDBd5NigQ>? MVGxJO69VQ>? NVP5UG9UOyCq M1vnWmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= M3PYRlI2ODF2N{e1
K562 MXnGeY5kfGmxbjDBd5NigQ>? NFm2WowyKM7:TR?= NHnXcW0{KGh? MVvJcohq[mm2aX;uJI9nKFB5MGO2T{BxcG:|cHjvdplt[XSrb36= NYPScYNwOjVyMUS3O|U>
K562 NUXNPGQ6TnWwY4Tpc44hSXO|YYm= MXmxJO69VQ>? MYCzJIg> M3\5SGlvcGmkaYTpc44hd2ZiR2PLN{BxcG:|cHjvdplt[XSrb36= MWGyOVAyPDd5NR?=
K562 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmruNUDPxE1? MWW3NkBp M{\LTWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvci=> NUjLcJUyOjVyMUS3O|U>
Primary AML cell M3vDPGZ2dmO2aX;uJGF{e2G7 NGC3ZY0yKM7:TR?= NIe1cXQ{KGh? MmLYTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w M3fm[VI2ODF2N{e1
Primary AML cell MlrtSpVv[3Srb36gRZN{[Xl? M1jjSFEh|ryP NFPMVVY{KGh? NV3keY8{UW6qaXLpeIlwdiCxZjDQO|BUPkticHjvd5Bpd3K7bHH0bY9v MVuyOVAyPDd5NR?=
Primary AML cell MlK1SpVv[3Srb36gRZN{[Xl? NEXGRVMyKM7:TR?= MlL2N{Bp NFXqWVRKdmirYnn0bY9vKG:oIFfTT|MheGixc4Doc5J6dGG2aX;u MnHhNlUxOTR5N{W=
Primary AML cell NV;FRWppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDPNUDPxE1? M4DyfVMhcA>? NEDYZ|RUfXCycnXzd4lwdiCxZjDyVm5CKHO7boTo[ZNqew>? NGHBcWMzPTBzNEe3OS=>
Microglia M4DyS2Z2dmO2aX;uJGF{e2G7 M4mzblUh|ryP NEDFR|MyOCCq NHPp[IhFVVOR M1HWSWRm[3KnYYPlJI9nKFSQRnGgd4VkemW2aX;uJIZzd21iTGDTMZN1cW23bHH0[YQhKHBzMUFOuGQ6OTCDL1S5NVBCKG2rY4Lv[4xq[Q>? NV7sXpcxOjR4MkW2PFQ>
Primary CLL cell MV;GeY5kfGmxbjDBd5NigQ>? M2S1VVEh|ryP MnzINVUhdWmw NH;wcWJFVVOR NWLpSGtnSmyxY3vzJGJEWi2rbnT1Z4VlKEyFUEGgd4VzcW6nLUWgZYN1cX[jdHnvci=> NIDW[4ozPDByOUKzNy=>
JEKO-1 MoHzSpVv[3Srb36gRZN{[Xl? M4j5S|Eh|ryP MXW3NkBp Mlv0TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJGloVS2|dHnteYxifGWmIFrFT28uOQ>? MYOyN|M1OTV2MR?=
Granta-519 MnfoSpVv[3Srb36gRZN{[Xl? Ml;NNUDPxE1? MYKyJIg> NF;i[5JKdmirYnn0bY9vKG:oIFHreEh1OzB6KTDwbI9{eGixconsZZRqd25? NIH5bXQzOzN2MUW0NS=>
Granta-519 M1fEXGZ2dmO2aX;uJGF{e2G7 NEjU[IUyKM7:TR?= NFzsSo8zKGh? MYHJcohq[mm2aX;uJI9nKEGtdDjzOFc{MSCyaH;zdIhwenmuYYTpc44> NHXnSpozOzN2MUW0NS=>
JEKO-1 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3uye|ExKM7:TR?= NHi3eYE4OiCq NFr4bW9KdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44he2yrZ3j0cJk> M3fQNFI{OzRzNUSx
JEKO-1 NInlcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXO1JO69VQ>? M1HYSlczKGh? Mnrq[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> MmGxNlM3PzZ{MkC=
MAVER-1 NWXKfotVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHaSlA2KM7:TR?= NIG0clg4OiCq MV\kc4V{KG6xdDDpcoR2[2ViY3XscEBkgWOuZTDhdpJme3Rib4KgZZBweHSxc3nz MYWyN|Y4PjJ{MB?=
MINO NX7ZWHBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TTXVUh|ryP MofFO|IhcA>? NHyyeYZld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ Mn7nNlM3PzZ{MkC=
SP53 M3rS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO1XpFxOC5zIN88US=> NWHQb3dXPzJiaB?= NW\rSWVY\G:nczDuc5QhcW6mdXPlJINmdGxiY4njcIUh[XK{ZYP0JI9zKGGyb4D0c5Nqew>? Ml3CNlM3PzZ{MkC=
HH M{D2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYCxNEDPxE1? NUDEU41bPzJiaB?= MkL2SG1UVw>? NXvsUXpUUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDzcIlocHSueR?= NVv6[HZYOjJ6MEG5OVk>
Myla MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmxNEDPxE1? MWO3NkBp MkTUSG1UVw>? NF6wc29ld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz NVT3Nm1UOjJ6MEG5OVk>
SR786 NGPVWZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nRPFExKM7:TR?= MmLRO|IhcA>? NHrDWXVFVVOR NXPuVXV{\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> Mnz4NlI5ODF7NUm=
HuT78 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoraNVAh|ryP NHezXGY4OiCq MUPEUXNQ NXvHVJJ5\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> NUeyWoVrOjJ6MEG5OVk>
MJ NWrzcG1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDlPVQyOCEQvF2= MlKyO|IhcA>? NXzTVplnTE2VTx?= NXjvS4Ns\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> NFzsTHYzOjhyMUm1PS=>
DERL7 NUPp[nF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LjR|ExKM7:TR?= NVLlW|hkPzJiaB?= MnXxSG1UVw>? NVfSfXRY\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MXOyNlgxOTl3OR?=
L1236 MlrqSpVv[3Srb36gRZN{[Xl? NFP3PZYyOCEQvF2= MWKyJIg> NYjjTIJmUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u NYfhVFdSOjJ{MUC4O|c>
L428 NFfUUXhHfW6ldHnvckBCe3OjeR?= NWnaW4R{OTBizszN NH7GNIkzKGh? NWmzTJZzUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u MljENlIzOTB6N{e=
L591 MlPVSpVv[3Srb36gRZN{[Xl? M3LNTFExKM7:TR?= NFruVW4zKGh? NVryNlJ[UW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u MonDNlIzOTB6N{e=
KMH-2 MmnRSpVv[3Srb36gRZN{[Xl? MW[xNEDPxE1? M4LnTFIhcA>? NUHhToszUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u MoW2NlIzOTB6N{e=
L1236 MXnGeY5kfGmxbjDBd5NigQ>? NGTEeZg2KM7:TR?= MWOyOEBp MUXCcI9kc3Nic3XjdoV1cW:wIH;mJJRp\SCFQ1y1 NHXL[YMzOjJzMEi3Oy=>
L591 NEL6[JpHfW6ldHnvckBCe3OjeR?= NVzJPIE{PSEQvF2= NHHTWZUzPCCq MU\CcI9kc3Nic3XjdoV1cW:wIH;mJJRp\SCFQ1y1 NU[xWllQOjJ{MUC4O|c>
L1236 MmjSRZBweHSxc3nzJGF{e2G7 M1vV[lUh|ryP NUTDdXFmOjRiaB?= NEPGd5RKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| MVGyNlIyODh5Nx?=
L591 MlHXRZBweHSxc3nzJGF{e2G7 M3fP[|Uh|ryP MkS1NlQhcA>? MnvYTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? NF[zUZkzOjJzMEi3Oy=>
U-87MG NXf0XmZPTnWwY4Tpc44hSXO|YYm= NEnRfGsyODBibl2= MoH3NlQhcA>? MmSySG1UVw>? MWTJcohq[mm2aX;uJI9nKCClZXzsJI1q\3KjdHnvci=> NXPJRVZjOjJyN{m2NFk>
SW1783 M4LySmZ2dmO2aX;uJGF{e2G7 NHfUd|IyODBibl2= MXmyOEBp Mnr4SG1UVw>? M1\GXWlvcGmkaYTpc44hd2ZiIHPlcIwhdWmpcnH0bY9v M4fRXlIzODd7NkC5
U-87MG MnLHSpVv[3Srb36gRZN{[Xl? M{\3c|Uh|ryP MXOyOEBp M3TEeGROW09? MX7Jcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25ic4Xid5RidnSrYXzsfS=> M3LxTFIzODd7NkC5
SW1783 M1nFTWZ2dmO2aX;uJGF{e2G7 MUW1JO69VQ>? NHy1W2IzPCCq M1[zVWROW09? NYfkPYxTUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJJN2[nO2YX70bYFtdHl? Mn61NlIxPzl4MEm=
U-373MG Ml74SpVv[3Srb36gRZN{[Xl? NUPKd2k6PSEQvF2= MVeyOEBp Mlz4SG1UVw>? NVOzPI1OUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJJN2[nO2YX70bYFtdHl? M2\YPFIzODd7NkC5
SK-MG3 NF\MSFZHfW6ldHnvckBCe3OjeR?= NEPHbWE2KM7:TR?= NGjzNHMzPCCq NUDRT2F1TE2VTx?= MnzKTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> M2fkWVIzODd7NkC5
SU-DHL-5 MUXGeY5kfGmxbjDBd5NigQ>? MkX5NUDPxE1? MX2yOEBp NE\WfpFFVVOR M3nMcGlv\HWldHnvckBw\iCjcH;weI9{cXN? MVWyNFk2QTZyNh?=
WSU-NHL MXnGeY5kfGmxbjDBd5NigQ>? M1fMPVEh|ryP MnnLNlQhcA>? M1S0dmROW09? MnjQTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? M3XvZlIxQTV7NkC2
CCRF-SB NWKxZmg5TnWwY4Tpc44hSXO|YYm= M{XINFEh|ryP MoHHNlQhcA>? MmrqSG1UVw>? NInFb2tKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| NEHCXWozODl3OU[wOi=>
INA-6 NHTQbFRHfW6ldHnvckBCe3OjeR?= MXu1JO69VQ>? NIS0V443KGh? M4DaU2lvcGmkaYTpc44hd2ZiUFmzT{9Cc3RiYX7kJGVTUyCyYYToe4F6 MnHqNlA2ODVzNUi=
LB NX\1VotPTnWwY4Tpc44hSXO|YYm= NWradotkPSEQvF2= MV22JIg> M4O0ZmlvcGmkaYTpc44hd2ZiUFm0T{9Cc3RiYX7kJGVTUyCyYYToe4F6 M2nI[lIxPTB3MUW4

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[2]
+ Expand

PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
Cell Research:[2]
+ Expand
  • Cell lines: CLL B cells or healthy volunteer T cells or NK cells
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48 hours
  • Method: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL warmed (199.79 mM)
Ethanol 23 mg/mL (55.36 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400 (dissolve first)+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 415.42
Formula

C22H18FN7O

CAS No. 870281-82-6
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03349346 Withdrawn Diffuse Large B-Cell Lymphoma|Mediastinal B-cell Lymphoma Gilead Sciences June 2019 Phase 1
NCT03349346 Withdrawn Diffuse Large B-Cell Lymphoma|Mediastinal B-cell Lymphoma Gilead Sciences June 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03639324 Not yet recruiting Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University March 30 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03639324 Not yet recruiting Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University March 30 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • Answer:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. https://www.ncbi.nlm.nih.gov/pubmed/24625684

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID