Idelalisib (CAL-101, GS-1101)

Catalog No.S2226

Idelalisib (CAL-101, GS-1101) Chemical Structure

Molecular Weight(MW): 415.42

Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

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Cited by 77 Publications

Purity & Quality Control

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Biological Activity

Description Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Targets
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
In vitro

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTEUXNQ NH\YXFBKSzVyPUKwMlQh|ryP Mn;xNlU6QTl|NUK=
CLL PBMCs NFzo[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PGWGROW09? NFrL[YZKSzVyPUKuPUBvVQ>? MXKyOVkyPzJ4Nx?=
U266 M3fnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVy0NEDPxE1? MkjKOFghcA>? MXy3PU42LSCrbnjpZol1cW:wIILheIU> NXjaWYlQOjV|M{mzN|I>
K562 M3O5XWZ2dmO2aX;uJGF{e2G7 NYDvfItLOSEQvF2= MonYN{Bp MnjzTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w NEnUVoMzPTBzNEe3OS=>
K562 NIrhfllHfW6ldHnvckBCe3OjeR?= MY[xJO69VQ>? NX7MU4N1OyCq NFTyb2ZKdmirYnn0bY9vKG:oIGC3NHM3UyCyaH;zdIhwenmuYYTpc44> M{DHdlI2ODF2N{e1
K562 NWfkWnd7TnWwY4Tpc44hSXO|YYm= M37KbFEh|ryP MXizJIg> Mmr2TY5pcWKrdHnvckBw\iCJU1uzJJBpd3OyaH;yfYxifGmxbh?= MonuNlUxOTR5N{W=
K562 NGK3RZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrONUDPxE1? Mn;5O|IhcA>? MoThTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;u MWKyOVAyPDd5NR?=
Primary AML cell NIjZZoRHfW6ldHnvckBCe3OjeR?= MWCxJO69VQ>? NW\zNHBQOyCq NVPsWJRSUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u NVzCZZJ7OjVyMUS3O|U>
Primary AML cell M4rwTmZ2dmO2aX;uJGF{e2G7 NUnSbIZzOSEQvF2= M{OweFMhcA>? MW\Jcohq[mm2aX;uJI9nKFB5MGO2T{BxcG:|cHjvdplt[XSrb36= M4PCbFI2ODF2N{e1
Primary AML cell NXi1TFdKTnWwY4Tpc44hSXO|YYm= MVyxJO69VQ>? NUfaW4VTOyCq MkLyTY5pcWKrdHnvckBw\iCJU1uzJJBpd3OyaH;yfYxifGmxbh?= NIPvbmszPTBzNEe3OS=>
Primary AML cell M37uWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTPWHNGOSEQvF2= NF\tUFI{KGh? Mn:3V5VxeHKnc4Ppc44hd2ZicmLORUB{gW62aHXzbZM> NGP2[W8zPTBzNEe3OS=>
Microglia NUfTbmI2TnWwY4Tpc44hSXO|YYm= M4f1VlUh|ryP Mm\uNVAhcA>? NWHncVVmTE2VTx?= Mlq1SIVkemWjc3Wgc4YhXE6IYTDz[YNz\XSrb36g[pJwdSCOUGOtd5RqdXWuYYTl[EAheDFzMN80SFkyOEFxREmxNGEhdWmlcn;ncIli M4r2UlI1PjJ3Nki0
Primary CLL cell MXfGeY5kfGmxbjDBd5NigQ>? NH7lc2QyKM7:TR?= NH3WeW4yPSCvaX6= MmTCSG1UVw>? NYC1VIhMSmyxY3vzJGJEWi2rbnT1Z4VlKEyFUEGgd4VzcW6nLUWgZYN1cX[jdHnvci=> MoXaNlQxODl{M{O=
JEKO-1 NXnnXW9STnWwY4Tpc44hSXO|YYm= NHnsS5UyKM7:TR?= MWS3NkBp MXfJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25iaX6gTYdONXO2aX31cIF1\WRiSlXLU{0y NF7oN5AzOzN2MUW0NS=>
Granta-519 MmPSSpVv[3Srb36gRZN{[Xl? MnPGNUDPxE1? NVX4WFdvOiCq MV7Jcohq[mm2aX;uJI9nKEGtdDj0N|A5MSCyaH;zdIhwenmuYYTpc44> NH[2PYQzOzN2MUW0NS=>
Granta-519 MUnGeY5kfGmxbjDBd5NigQ>? MkPONUDPxE1? NGnWSHozKGh? MkfmTY5pcWKrdHnvckBw\iCDa4Sod|Q4OylicHjvd5Bpd3K7bHH0bY9v NEHjVmQzOzN2MUW0NS=>
JEKO-1 NH2wZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fjW|ExKM7:TR?= MYC3NkBp NWLMOW1wUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKHOuaXfoeIx6 M3vMOVI{OzRzNUSx
JEKO-1 NFSxZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXaOUDPxE1? NU\rW4Q1PzJiaB?= MofR[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> MXqyN|Y4PjJ{MB?=
MAVER-1 NInDS|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXSOUDPxE1? MXe3NkBp M3:3XYRw\XNibn;0JIlv\HWlZTDj[YxtKGO7Y3zlJIFzemW|dDDvdkBieG:ydH;zbZM> MVyyN|Y4PjJ{MB?=
MINO M{fpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfI[nc2KM7:TR?= MWG3NkBp MUfkc4V{KG6xdDDpcoR2[2ViY3XscEBkgWOuZTDhdpJme3Rib4KgZZBweHSxc3nz NVr0R|R3OjN4N{[yNlA>
SP53 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XoSFAvOSEQvF2= M{HVZVczKGh? NELCeIdld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ NH7BVYszOzZ5NkKyNC=>
HH MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPiNHYyOCEQvF2= NV:1bYsxPzJiaB?= MVLEUXNQ NYnsZlFLUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDzcIlocHSueR?= M3TYN|IzQDBzOUW5
Myla NHrCc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWSxNEDPxE1? NUC1VIo5PzJiaB?= MV;EUXNQ MmrB[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= NXLLTHc5OjJ6MEG5OVk>
SR786 NWnvWoVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYewXWFUOTBizszN MYC3NkBp MVXEUXNQ NU\3dWhj\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MlH1NlI5ODF7NUm=
HuT78 Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2xNEDPxE1? NIrMdnQ4OiCq MYrEUXNQ NIPXfJRld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz M2DxflIzQDBzOUW5
MJ NH:4fXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;PNVAh|ryP MmDSO|IhcA>? NUTYRlc{TE2VTx?= NXTVXYVT\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MnrMNlI5ODF7NUm=
DERL7 NGjr[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr1XnZJOTBizszN MWK3NkBp NWPxOGRMTE2VTx?= NWW3[oFO\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MnjKNlI5ODF7NUm=
L1236 NH;GcHFHfW6ldHnvckBCe3OjeR?= NF31ZlUyOCEQvF2= MmfqNkBp Mmn0TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w MkjlNlIzOTB6N{e=
L428 Mnz6SpVv[3Srb36gRZN{[Xl? MWKxNEDPxE1? NV7QXZMxOiCq MXfJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NVH3NnZTOjJ{MUC4O|c>
L591 MkDvSpVv[3Srb36gRZN{[Xl? M3TFW|ExKM7:TR?= M{\QT|IhcA>? M{PtWWlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= M1n2XlIzOjFyOEe3
KMH-2 NIXOWJhHfW6ldHnvckBCe3OjeR?= MXGxNEDPxE1? M3X2N|IhcA>? M1LuRmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= Mm\KNlIzOTB6N{e=
L1236 M2PqOWZ2dmO2aX;uJGF{e2G7 Ml7lOUDPxE1? NVfEeWQzOjRiaB?= NXjOPJBkSmyxY3vzJJNm[3KndHnvckBw\iC2aHWgR2NNPQ>? M{jlXVIzOjFyOEe3
L591 NHPnPVlHfW6ldHnvckBCe3OjeR?= M3XqOVUh|ryP M4LLTVI1KGh? NXPMcohZSmyxY3vzJJNm[3KndHnvckBw\iC2aHWgR2NNPQ>? Mlj2NlIzOTB6N{e=
L1236 M2PreGFxd3C2b4Ppd{BCe3OjeR?= MlftOUDPxE1? M{\sclI1KGh? Mk\ITY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? M{X2UlIzOjFyOEe3
L591 NIDwZZVCeG:ydH;zbZMhSXO|YYm= MYm1JO69VQ>? NIjBNWYzPCCq MWPJcoR2[3Srb36gc4Yh[XCxcITvd4l{ NVXxdmI3OjJ{MUC4O|c>
U-87MG Ml21SpVv[3Srb36gRZN{[Xl? M{DVTFExOCCwTR?= MYqyOEBp Ml;2SG1UVw>? MlzMTY5pcWKrdHnvckBw\iBiY3XscEBucWe{YYTpc44> Ml7WNlIxPzl4MEm=
SW1783 MUjGeY5kfGmxbjDBd5NigQ>? NGXpZ5gyODBibl2= M1nXWVI1KGh? NIf6RpdFVVOR Mn3qTY5pcWKrdHnvckBw\iBiY3XscEBucWe{YYTpc44> M2GzVFIzODd7NkC5
U-87MG MUHGeY5kfGmxbjDBd5NigQ>? M3PvTFUh|ryP NXS4O|lbOjRiaB?= MlPtSG1UVw>? MlvqTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> MmDFNlIxPzl4MEm=
SW1783 MX;GeY5kfGmxbjDBd5NigQ>? MnLJOUDPxE1? NXLCSG9nOjRiaB?= MnXTSG1UVw>? M{fjUWlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDzeYJ{fGGwdHnhcIx6 NIDET4gzOjB5OU[wPS=>
U-373MG NFvhRYFHfW6ldHnvckBCe3OjeR?= M33mdFUh|ryP NUTDbVJ3OjRiaB?= NHX3bXJFVVOR M{DD[WlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDzeYJ{fGGwdHnhcIx6 MXeyNlA4QTZyOR?=
SK-MG3 MVLGeY5kfGmxbjDBd5NigQ>? NHTDOpc2KM7:TR?= NXzIfXhpOjRiaB?= NHj1c|dFVVOR MULJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25ic4Xid5RidnSrYXzsfS=> NX3xNJFbOjJyN{m2NFk>
SU-DHL-5 NXPxU3huTnWwY4Tpc44hSXO|YYm= MmPPNUDPxE1? MUCyOEBp M2r6dmROW09? M1XFb2lv\HWldHnvckBw\iCjcH;weI9{cXN? M4\vNlIxQTV7NkC2
WSU-NHL MnS3SpVv[3Srb36gRZN{[Xl? NVnDS2VTOSEQvF2= NHLOV4YzPCCq NEnJdGVFVVOR NWKye2VjUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?= NUjBZpNIOjB7NUm2NFY>
CCRF-SB NXvKdnRUTnWwY4Tpc44hSXO|YYm= NXHBXHRuOSEQvF2= M3X2WlI1KGh? MlvLSG1UVw>? NGHIRVhKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M4rJTVIxQTV7NkC2
INA-6 Ml3CSpVv[3Srb36gRZN{[Xl? MY[1JO69VQ>? NIDuTpM3KGh? MUfJcohq[mm2aX;uJI9nKFCLM1uvRYt1KGGwZDDFVmsheGG2aIfhfS=> NXnPUYl5OjB3MEWxOVg>
LB MXzGeY5kfGmxbjDBd5NigQ>? NHLPSJM2KM7:TR?= NIjWPY83KGh? MYTJcohq[mm2aX;uJI9nKFCLNFuvRYt1KGGwZDDFVmsheGG2aIfhfS=> NIrKbY4zODVyNUG1PC=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PUMA / p53 ; 

PubMed: 28008149     


Parental and p53-KD HCT116 cells were treated with 10 μmol/L idelalisib for 24 hours. PUMA expression was analyzed by Western blotting.

Bim / Bcl-xl / Bid / Mcl-1; 

PubMed: 28008149     


HCT116 cells treated with 10 μmol/L idelalisib at indicated time point. The expression of indicated Bcl-2 family members was analyzed by Western blotting.

p-p65; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. p-p65 (S536) and p65 expression was analyzed by Western blotting.

p-AKT / AKT; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. Total AKT and p-AKT expression was analyzed Western blotting.

Cleaved caspase 3 / Cleaved caspase 9; 

PubMed: 28008149     


HepG2 cells were treated with 5μmol/L idelalisib at indicated time point. Cleaved-caspase 3 and 9 were analyzed by western blotting.

Mcl-1 / Bcl-2 / Bid / Bcl-xl / Noxa / Bak / Bax ; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib at indicated time points. The expression of indicated Bcl-2 family members was analyzed by western blotting and normalized to β-actin. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test).

p-FoxO3a / FoxO3a; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib for 24 h. Indicated protein expression was analyzed by western blotting and p-FoxO3a normalized to FoxO3a, p-AKT normalized to AKT. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test). 

Akt(T308) / PDK1(S241) / GSK-3β(S9); 

PubMed: 27342398     


JeKo-1, Mino, and Granta 519 cells or cells from four different MCL patients were serum-starved for 1h and then treated with DMSO, or with 0.5, 1, or 3μM for 1h; the cells were then co-cultured with IgM (10ng/μL) for 15min before harvesting. Cell extracts were prepared, and 30μg (cell lines) or 50μg (primary cells) protein was loaded for immunoblot analyses. The effects of idelalisib on Akt (Thr308) and total Akt, PDK1 (Ser241) and total PDK1, GS3K-3β (Ser9) and total GSK-3β protein expression levels were detected in (A) JeKo-1, Mino and Granta 519 cells.

28008149 30224718 27342398
Growth inhibition assay
Cell viability; 

PubMed: 28008149     


Indicated cell lines were treated with different concentrations of idelalisib for 72 hours. Cell proliferation was determined by MTS assay. Results were expressed as means ± SD of three independent experiments.

Cell viability; 

PubMed: 30224718     


The indicated cell lines were treated with increasing concentrations of idelalisib for 72 h. Cell viability was determined by MTS assay.

28008149 30224718

Protocol

Kinase Assay:[2]
+ Expand

PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
Cell Research:[2]
+ Expand
  • Cell lines: CLL B cells or healthy volunteer T cells or NK cells
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48 hours
  • Method: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL warmed (199.79 mM)
Ethanol 23 mg/mL (55.36 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400 (dissolve first)+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 415.42
Formula

C22H18FN7O

CAS No. 870281-82-6
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03639324 Not yet recruiting Drug: Rituximab Idelalisib and Venetoclax Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University September 30 2019 Phase 1
NCT03582098 Completed Drug: Idelalisib|Drug: Rituximab Chronic Lymphocytic Leukaemia Gilead Sciences September 12 2018 --
NCT03151057 Recruiting Drug: Idelalisib 100 MG|Drug: Placebo Oral Tablet B Cells-Tumors|B Cell Chronic Lymphocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|Large B-Cell Diffuse Lymphoma of Bone (Diagnosis) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Gilead Sciences July 31 2018 Phase 1
NCT03568929 Recruiting Drug: Idelalisib Follicular Non-Hodgkin''s Lymphoma Refractory Gilead Sciences May 25 2018 --
NCT03310190 Recruiting -- Chronic Lymphocytic Leukemia AbbVie January 10 2018 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • Answer:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. https://www.ncbi.nlm.nih.gov/pubmed/24625684

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID