Idelalisib (CAL-101, GS-1101)

For research use only. Not for use in humans.

Catalog No.S2226

117 publications

Idelalisib (CAL-101, GS-1101) Chemical Structure

Molecular Weight(MW): 415.42

Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

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Selleck's Idelalisib (CAL-101, GS-1101) has been cited by 117 publications

Purity & Quality Control

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Biological Activity

Description Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Targets
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
In vitro

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 M3\UT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLzcVdPTE2VTx?= MULJR|UxRTJyLkSg{txO MX6yOVk6QTN3Mh?=
CLL PBMCs MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvJU5VFVVOR MVPJR|UxRTJwOTDuUS=> M4XHcVI2QTF5Mk[3
U266 NInj[oZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fabFQxKM7:TR?= M{O3[VQ5KGh? NFjnTnI4QS53JTDpcohq[mm2aX;uJJJifGV? MXyyOVM{QTN|Mh?=
K562 M4HiOmZ2dmO2aX;uJGF{e2G7 MWCxJO69VQ>? MlnhN{Bp MmOwTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w M4rMWVI2ODF2N{e1
K562 M4DSb2Z2dmO2aX;uJGF{e2G7 NXjXUVU2OSEQvF2= M2\uR|MhcA>? NITQe4xKdmirYnn0bY9vKG:oIGC3NHM3UyCyaH;zdIhwenmuYYTpc44> M3\3TVI2ODF2N{e1
K562 Mo\sSpVv[3Srb36gRZN{[Xl? MmfoNUDPxE1? M2H3VVMhcA>? MYDJcohq[mm2aX;uJI9nKEeVS{OgdIhwe3Cqb4L5cIF1cW:w MlzFNlUxOTR5N{W=
K562 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3yZ2JDOSEQvF2= NVXmXpEzPzJiaB?= MlnRTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;u NGDXfI8zPTBzNEe3OS=>
Primary AML cell MWfGeY5kfGmxbjDBd5NigQ>? NYTzSpBxOSEQvF2= MmriN{Bp MULJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NGe1W20zPTBzNEe3OS=>
Primary AML cell MXPGeY5kfGmxbjDBd5NigQ>? NIDJOVcyKM7:TR?= MmK5N{Bp NX3nT2JtUW6qaXLpeIlwdiCxZjDQO|BUPkticHjvd5Bpd3K7bHH0bY9v MlTsNlUxOTR5N{W=
Primary AML cell MlfMSpVv[3Srb36gRZN{[Xl? MXKxJO69VQ>? NGHuUWQ{KGh? MVTJcohq[mm2aX;uJI9nKEeVS{OgdIhwe3Cqb4L5cIF1cW:w MnvsNlUxOTR5N{W=
Primary AML cell NILmRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzzNUDPxE1? NHXmdGw{KGh? NVnmOlZ{W3WycILld5Nqd25ib3[gdnJPSSC|eX70bIV{cXN? NVPKc4VGOjVyMUS3O|U>
Microglia M2LOSmZ2dmO2aX;uJGF{e2G7 NIT4RWk2KM7:TR?= MUGxNEBp M2q3NGROW09? Ml\3SIVkemWjc3Wgc4YhXE6IYTDz[YNz\XSrb36g[pJwdSCOUGOtd5RqdXWuYYTl[EAheDFzMN80SFkyOEFxREmxNGEhdWmlcn;ncIli M3;5TVI1PjJ3Nki0
Primary CLL cell MY\GeY5kfGmxbjDBd5NigQ>? NXTubm03OSEQvF2= MmnaNVUhdWmw Mn7tSG1UVw>? NVrrOYpZSmyxY3vzJGJEWi2rbnT1Z4VlKEyFUEGgd4VzcW6nLUWgZYN1cX[jdHnvci=> Mo\XNlQxODl{M{O=
JEKO-1 NEfIeGhHfW6ldHnvckBCe3OjeR?= NW\sVY5POSEQvF2= NH\jXIo4OiCq Mk\LTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJGloVS2|dHnteYxifGWmIFrFT28uOQ>? M2TuPVI{OzRzNUSx
Granta-519 M3j3RmZ2dmO2aX;uJGF{e2G7 M4DnU|Eh|ryP MYOyJIg> MmXaTY5pcWKrdHnvckBw\iCDa4SoeFMxQClicHjvd5Bpd3K7bHH0bY9v MYSyN|M1OTV2MR?=
Granta-519 NYe2W2RKTnWwY4Tpc44hSXO|YYm= MVexJO69VQ>? NYTwNI5bOiCq NGP5O4dKdmirYnn0bY9vKG:oIFHreEh{PDd|KTDwbI9{eGixconsZZRqd25? MlvENlM{PDF3NEG=
JEKO-1 Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPU[lBoOTBizszN M1\Wb|czKGh? M3vQb2lvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckB{dGmpaITsfS=> MoXNNlM{PDF3NEG=
JEKO-1 NV35O|k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHv0Vnk2KM7:TR?= MXO3NkBp NIjleppld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ NUXCTYh1OjN4N{[yNlA>
MAVER-1 MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;PelUh|ryP M3e1N|czKGh? NHjOeo1ld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ M3W5U|I{Pjd4MkKw
MINO NEXvfXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnXRYE2KM7:TR?= MorZO|IhcA>? M1nOOIRw\XNibn;0JIlv\HWlZTDj[YxtKGO7Y3zlJIFzemW|dDDvdkBieG:ydH;zbZM> NYm0U|M2OjN4N{[yNlA>
SP53 NEfVfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknBNE4yKM7:TR?= MnzmO|IhcA>? M3ywWoRw\XNibn;0JIlv\HWlZTDj[YxtKGO7Y3zlJIFzemW|dDDvdkBieG:ydH;zbZM> Mlr1NlM3PzZ{MkC=
HH Mn;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrzSmNvOTBizszN Ml3OO|IhcA>? NVy0eFNtTE2VTx?= NYrBUVdwUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDzcIlocHSueR?= M2ixbVIzQDBzOUW5
Myla NX3mN4VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf0O2UyOCEQvF2= MX[3NkBp MXjEUXNQ MkL1[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= Mmq5NlI5ODF7NUm=
SR786 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHvWo8yOCEQvF2= M{D0bFczKGh? M2HzU2ROW09? MXHkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m| MnLrNlI5ODF7NUm=
HuT78 NUHzSGZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVOxNEDPxE1? M33MelczKGh? NWOweYhjTE2VTx?= NGTteFFld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz M4Tp[|IzQDBzOUW5
MJ MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;n[pNEOTBizszN NFzB[lE4OiCq MkjjSG1UVw>? NYfuc2l7\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppdy=> MkXaNlI5ODF7NUm=
DERL7 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\YbVExKM7:TR?= M3vWUVczKGh? NXOz[HNuTE2VTx?= MU\kc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m| M3nYUFIzQDBzOUW5
L1236 Mo\0SpVv[3Srb36gRZN{[Xl? M1\ISFExKM7:TR?= MkPlNkBp NHPafnZKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= Mn;2NlIzOTB6N{e=
L428 MYLGeY5kfGmxbjDBd5NigQ>? NVL4[XNUOTBizszN MWmyJIg> MWDJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? MmGxNlIzOTB6N{e=
L591 NYrHTJBiTnWwY4Tpc44hSXO|YYm= NWL2ZXVYOTBizszN MV:yJIg> NEfYZnVKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= NH\VOpozOjJzMEi3Oy=>
KMH-2 MoC0SpVv[3Srb36gRZN{[Xl? NGC2SlEyOCEQvF2= NX3rcJdnOiCq MU\Jcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NGi5T3IzOjJzMEi3Oy=>
L1236 NI\mdoJHfW6ldHnvckBCe3OjeR?= NHvCVG02KM7:TR?= NWrYRm53OjRiaB?= MmfQRoxw[2u|IIPlZ5JmfGmxbjDv[kB1cGViQ1PMOS=> M{L6dFIzOjFyOEe3
L591 MnzxSpVv[3Srb36gRZN{[Xl? NVu2SmdmPSEQvF2= NFG1Z28zPCCq M4PpU2Jtd2OtczDz[YNz\XSrb36gc4YhfGinIFPDUFU> NUXhTpE6OjJ{MUC4O|c>
L1236 MVPBdI9xfG:|aYOgRZN{[Xl? M2X3T|Uh|ryP NGPTN4QzPCCq MX3JcoR2[3Srb36gc4Yh[XCxcITvd4l{ MWKyNlIyODh5Nx?=
L591 MWPBdI9xfG:|aYOgRZN{[Xl? MorZOUDPxE1? M3z0UVI1KGh? NFL4eZdKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M1r0[FIzOjFyOEe3
U-87MG MnrKSpVv[3Srb36gRZN{[Xl? M3:xcFExOCCwTR?= NUPlXHRnOjRiaB?= M2HNcGROW09? NFLEUXFKdmirYnn0bY9vKG:oIDDj[YxtKG2rZ4LheIlwdg>? MV6yNlA4QTZyOR?=
SW1783 NFyzdmxHfW6ldHnvckBCe3OjeR?= NEjxWnYyODBibl2= Mn;wNlQhcA>? NHq3WnFFVVOR NV[1VYdoUW6qaXLpeIlwdiCxZjCgZ4VtdCCvaXfyZZRqd25? M4C2NFIzODd7NkC5
U-87MG NUPxOlNCTnWwY4Tpc44hSXO|YYm= NV7MfZZyPSEQvF2= MorVNlQhcA>? MYXEUXNQ Ml;CTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> MkjNNlIxPzl4MEm=
SW1783 NUW1UVhqTnWwY4Tpc44hSXO|YYm= NHG1Oo42KM7:TR?= MmXTNlQhcA>? NIPhTZhFVVOR NX3VclN2UW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJJN2[nO2YX70bYFtdHl? M{jtbFIzODd7NkC5
U-373MG NWnzNY1ZTnWwY4Tpc44hSXO|YYm= M1L0eVUh|ryP MlSwNlQhcA>? M{\tfWROW09? MlW4TY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> NXO4TIMzOjJyN{m2NFk>
SK-MG3 NV\QbodtTnWwY4Tpc44hSXO|YYm= NWi2THJ2PSEQvF2= M{LmcFI1KGh? NYWyeIlpTE2VTx?= NWWxPVZIUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJJN2[nO2YX70bYFtdHl? NFvtW4MzOjB5OU[wPS=>
SU-DHL-5 NWLIVZFFTnWwY4Tpc44hSXO|YYm= MVixJO69VQ>? M2DoV|I1KGh? NHq2TZVFVVOR MnLmTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? MnrQNlA6PTl4ME[=
WSU-NHL MUnGeY5kfGmxbjDBd5NigQ>? M{LtZVEh|ryP NEOyZVQzPCCq MlP5SG1UVw>? M1jMNWlv\HWldHnvckBw\iCjcH;weI9{cXN? M2[1U|IxQTV7NkC2
CCRF-SB MonOSpVv[3Srb36gRZN{[Xl? NVrQbWtbOSEQvF2= MYmyOEBp M{Lq[2ROW09? Mk\JTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? M4DlPFIxQTV7NkC2
INA-6 NF7PNG5HfW6ldHnvckBCe3OjeR?= M4HlcFUh|ryP NF6zdG83KGh? M4nyfmlvcGmkaYTpc44hd2ZiUFmzT{9Cc3RiYX7kJGVTUyCyYYToe4F6 M4ToUFIxPTB3MUW4
LB NWrZN4ZXTnWwY4Tpc44hSXO|YYm= NE\uSGw2KM7:TR?= MlHSOkBp MYDJcohq[mm2aX;uJI9nKFCLNFuvRYt1KGGwZDDFVmsheGG2aIfhfS=> MWqyNFUxPTF3OB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PUMA / p53 ; 

PubMed: 28008149     


Parental and p53-KD HCT116 cells were treated with 10 μmol/L idelalisib for 24 hours. PUMA expression was analyzed by Western blotting.

Bim / Bcl-xl / Bid / Mcl-1; 

PubMed: 28008149     


HCT116 cells treated with 10 μmol/L idelalisib at indicated time point. The expression of indicated Bcl-2 family members was analyzed by Western blotting.

p-p65; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. p-p65 (S536) and p65 expression was analyzed by Western blotting.

p-AKT / AKT; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. Total AKT and p-AKT expression was analyzed Western blotting.

Cleaved caspase 3 / Cleaved caspase 9; 

PubMed: 28008149     


HepG2 cells were treated with 5μmol/L idelalisib at indicated time point. Cleaved-caspase 3 and 9 were analyzed by western blotting.

Mcl-1 / Bcl-2 / Bid / Bcl-xl / Noxa / Bak / Bax ; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib at indicated time points. The expression of indicated Bcl-2 family members was analyzed by western blotting and normalized to β-actin. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test).

p-FoxO3a / FoxO3a; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib for 24 h. Indicated protein expression was analyzed by western blotting and p-FoxO3a normalized to FoxO3a, p-AKT normalized to AKT. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test). 

Akt(T308) / PDK1(S241) / GSK-3β(S9); 

PubMed: 27342398     


JeKo-1, Mino, and Granta 519 cells or cells from four different MCL patients were serum-starved for 1h and then treated with DMSO, or with 0.5, 1, or 3μM for 1h; the cells were then co-cultured with IgM (10ng/μL) for 15min before harvesting. Cell extracts were prepared, and 30μg (cell lines) or 50μg (primary cells) protein was loaded for immunoblot analyses. The effects of idelalisib on Akt (Thr308) and total Akt, PDK1 (Ser241) and total PDK1, GS3K-3β (Ser9) and total GSK-3β protein expression levels were detected in (A) JeKo-1, Mino and Granta 519 cells.

28008149 30224718 27342398
Growth inhibition assay
Cell viability; 

PubMed: 28008149     


Indicated cell lines were treated with different concentrations of idelalisib for 72 hours. Cell proliferation was determined by MTS assay. Results were expressed as means ± SD of three independent experiments.

Cell viability; 

PubMed: 30224718     


The indicated cell lines were treated with increasing concentrations of idelalisib for 72 h. Cell viability was determined by MTS assay.

28008149 30224718

Protocol

Kinase Assay:[2]
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PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
Cell Research:[2]
- Collapse
  • Cell lines: CLL B cells or healthy volunteer T cells or NK cells
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48 hours
  • Method: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL warmed (199.79 mM)
Ethanol 23 mg/mL (55.36 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+20%PEG 300+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 415.42
Formula

C22H18FN7O

CAS No. 870281-82-6
Storage powder
in solvent
Synonyms N/A
Smiles CCC(NC1=C2N=C[NH]C2=NC=N1)C3=NC4=CC=CC(=C4C(=O)N3C5=CC=CC=C5)F

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03639324 Not yet recruiting Drug: Rituximab Idelalisib and Venetoclax Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University September 30 2019 Phase 1
NCT03582098 Completed Drug: Idelalisib|Drug: Rituximab Chronic Lymphocytic Leukaemia Gilead Sciences September 12 2018 --
NCT03151057 Recruiting Drug: Idelalisib 100 MG|Drug: Placebo Oral Tablet B Cells-Tumors|B Cell Chronic Lymphocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|Large B-Cell Diffuse Lymphoma of Bone (Diagnosis) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Gilead Sciences July 31 2018 Phase 1
NCT03568929 Recruiting Drug: Idelalisib Follicular Non-Hodgkin''s Lymphoma Refractory Gilead Sciences May 25 2018 --
NCT03310190 Recruiting -- Chronic Lymphocytic Leukemia AbbVie January 10 2018 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • Answer:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. https://www.ncbi.nlm.nih.gov/pubmed/24625684

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID