Idelalisib (CAL-101, GS-1101)

For research use only.

Catalog No.S2226

160 publications

Idelalisib (CAL-101, GS-1101) Chemical Structure

CAS No. 870281-82-6

Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.

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Selleck's Idelalisib (CAL-101, GS-1101) has been cited by 160 publications

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Biological Activity

Description Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.
Targets
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
In vitro

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojYSG1UVw>? NFHwcmhKSzVyPUKwMlQh|ryP MmfRNlU6QTl|NUK=
CLL PBMCs NGPrcJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXTeHBXTE2VTx?= Mn;lTWM2OD1{Lkmgcm0> Mo\wNlU6OTd{Nke=
U266 NEnudHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHofWU1OCEQvF2= NVn1d4c2PDhiaB?= M2rZNFc6NjVnIHnubIljcXSrb36gdoF1\Q>? M3\JWlI2OzN7M{Oy
K562 MXPGeY5kfGmxbjDBd5NigQ>? Mm\kNUDPxE1? MmjaN{Bp NWfWVHhMUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u NWHSTGZYOjVyMUS3O|U>
K562 NVvCZmxPTnWwY4Tpc44hSXO|YYm= M1jjeVEh|ryP NWrBZ2NROyCq MkLOTY5pcWKrdHnvckBw\iCSN{DTOmsheGixc4Doc5J6dGG2aX;u MX:yOVAyPDd5NR?=
K562 MWTGeY5kfGmxbjDBd5NigQ>? MmHrNUDPxE1? NXLiNo1SOyCq NHfuTmlKdmirYnn0bY9vKG:oIFfTT|MheGixc4Doc5J6dGG2aX;u MmnTNlUxOTR5N{W=
K562 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV60SnJZOSEQvF2= M{HhdVczKGh? MoPpTY5pcWKrdHnvckBw\iCycn;sbYZmemG2aX;u M1:zV|I2ODF2N{e1
Primary AML cell M3rYTGZ2dmO2aX;uJGF{e2G7 MkXlNUDPxE1? MlPhN{Bp MljaTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w MXqyOVAyPDd5NR?=
Primary AML cell NV\5SplHTnWwY4Tpc44hSXO|YYm= NW\kO|NYOSEQvF2= MXqzJIg> MmfwTY5pcWKrdHnvckBw\iCSN{DTOmsheGixc4Doc5J6dGG2aX;u MUCyOVAyPDd5NR?=
Primary AML cell NHSzbnhHfW6ldHnvckBCe3OjeR?= MUmxJO69VQ>? M3\Ob|MhcA>? M3\1[GlvcGmkaYTpc44hd2ZiR2PLN{BxcG:|cHjvdplt[XSrb36= MXWyOVAyPDd5NR?=
Primary AML cell M1\rOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq1[YRuOSEQvF2= NH;icHQ{KGh? NGq5VVdUfXCycnXzd4lwdiCxZjDyVm5CKHO7boTo[ZNqew>? NU\CcZpqOjVyMUS3O|U>
Microglia NUfMXHBDTnWwY4Tpc44hSXO|YYm= NE\6SYY2KM7:TR?= NIP4V|UyOCCq NVvSSI8zTE2VTx?= NIO4XZhF\WO{ZXHz[UBw\iCWTl\hJJNm[3KndHnvckBnem:vIFzQV{1{fGmvdXzheIVlKCCyMUGw{tRFQTFyQT;EPVExSSCvaXPyc4dtcWF? MmjvNlQ3OjV4OES=
Primary CLL cell M1LmO2Z2dmO2aX;uJGF{e2G7 MYixJO69VQ>? MljONVUhdWmw NEDOZ3FFVVOR MULCcI9kc3NiQlPSMYlv\HWlZXSgUGNROSC|ZYLpcoUuPSCjY4TpeoF1cW:w M3f3XFI1ODB7MkOz
JEKO-1 MXTGeY5kfGmxbjDBd5NigQ>? MXixJO69VQ>? NI\UcXo4OiCq NXPLWVRHUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJIlvKEmpTT3zeIlufWyjdHXkJGpGU09vMR?= MYGyN|M1OTV2MR?=
Granta-519 NFOxdXVHfW6ldHnvckBCe3OjeR?= NFLJS4kyKM7:TR?= M{TFNFIhcA>? NYewRpJtUW6qaXLpeIlwdiCxZjDBb5QpfDNyODmgdIhwe3Cqb4L5cIF1cW:w NF\UN|UzOzN2MUW0NS=>
Granta-519 NE\CfZlHfW6ldHnvckBCe3OjeR?= M{KwTFEh|ryP NUT1bYU2OiCq M1X4S2lvcGmkaYTpc44hd2ZiQXv0LJM1PzNrIIDoc5NxcG:{eXzheIlwdg>? MkPwNlM{PDF3NEG=
JEKO-1 M{XFZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vHTFExKM7:TR?= NH\mSHE4OiCq NYLwVGF5UW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKHOuaXfoeIx6 NHHuXnMzOzN2MUW0NS=>
JEKO-1 Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrQfVU2KM7:TR?= Mk\0O|IhcA>? NVPIS5E1\G:nczDuc5QhcW6mdXPlJINmdGxiY4njcIUh[XK{ZYP0JI9zKGGyb4D0c5Nqew>? NGS1[4MzOzZ5NkKyNC=>
MAVER-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXO1JO69VQ>? M4rvWFczKGh? NFrTT2dld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ M4\HelI{Pjd4MkKw
MINO MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe1JO69VQ>? MX[3NkBp NF;rNo1ld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ NYPVXYhZOjN4N{[yNlA>
SP53 NHnRS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS4NE4yKM7:TR?= MlWwO|IhcA>? NWPxcY1K\G:nczDuc5QhcW6mdXPlJINmdGxiY4njcIUh[XK{ZYP0JI9zKGGyb4D0c5Nqew>? MUKyN|Y4PjJ{MB?=
HH NWPMV5d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLwNVAh|ryP NWDpd4VlPzJiaB?= MnXlSG1UVw>? MmTyTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyC|bHnnbJRtgQ>? MoToNlI5ODF7NUm=
Myla NGmy[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKzNVAh|ryP NWPvN4lRPzJiaB?= MmTpSG1UVw>? M3PwNYRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYO= MlPSNlI5ODF7NUm=
SR786 M{Hsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljqNVAh|ryP NFfqVI44OiCq MYLEUXNQ NITQdYRld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz MYOyNlgxOTl3OR?=
HuT78 NGXhUGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDOeXUyOCEQvF2= NUjsXlkzPzJiaB?= M1y3OGROW09? MkXy[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= MYSyNlgxOTl3OR?=
MJ NF\0XW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zPNFExKM7:TR?= NFfXSpo4OiCq M4LuZmROW09? NG\kTIpld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz Mm\TNlI5ODF7NUm=
DERL7 NWKySohVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nDNlExKM7:TR?= NELG[484OiCq MWPEUXNQ M2TEV4Rw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYO= M3nxVFIzQDBzOUW5
L1236 MXrGeY5kfGmxbjDBd5NigQ>? NFuxRXcyOCEQvF2= MoHlNkBp Mn3xTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:w NUDZRldYOjJ{MUC4O|c>
L428 NXTmUJFWTnWwY4Tpc44hSXO|YYm= NIPqUmQyOCEQvF2= MmfFNkBp NVnEW3RuUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u MnK5NlIzOTB6N{e=
L591 NEnBUYFHfW6ldHnvckBCe3OjeR?= M3T3[FExKM7:TR?= Mn7HNkBp NILyOFhKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= M1LwV|IzOjFyOEe3
KMH-2 NYXxVXd2TnWwY4Tpc44hSXO|YYm= MWmxNEDPxE1? MY[yJIg> MXXJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NX7zbIJUOjJ{MUC4O|c>
L1236 M{flOWZ2dmO2aX;uJGF{e2G7 MmXmOUDPxE1? MmLXNlQhcA>? M1fkTWJtd2OtczDz[YNz\XSrb36gc4YhfGinIFPDUFU> NF\we44zOjJzMEi3Oy=>
L591 MYDGeY5kfGmxbjDBd5NigQ>? MmLWOUDPxE1? Mof1NlQhcA>? MljLRoxw[2u|IIPlZ5JmfGmxbjDv[kB1cGViQ1PMOS=> MVmyNlIyODh5Nx?=
L1236 NU\M[HlzSXCxcITvd4l{KEG|c3H5 NEXiWYc2KM7:TR?= M3vWPFI1KGh? NXvhSpFJUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?= MXeyNlIyODh5Nx?=
L591 M2DUfmFxd3C2b4Ppd{BCe3OjeR?= MY[1JO69VQ>? MnHyNlQhcA>? NVniOlJsUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?= NUXXe5RnOjJ{MUC4O|c>
U-87MG MXjGeY5kfGmxbjDBd5NigQ>? MlvyNVAxKG6P M13iT|I1KGh? M4njWmROW09? MXzJcohq[mm2aX;uJI9nKCClZXzsJI1q\3KjdHnvci=> MkfkNlIxPzl4MEm=
SW1783 MnzYSpVv[3Srb36gRZN{[Xl? M1fIUVExOCCwTR?= MlLHNlQhcA>? MoX3SG1UVw>? MWPJcohq[mm2aX;uJI9nKCClZXzsJI1q\3KjdHnvci=> MoDoNlIxPzl4MEm=
U-87MG Mn\ESpVv[3Srb36gRZN{[Xl? NG\xSZo2KM7:TR?= NXTyUodoOjRiaB?= MlLWSG1UVw>? M3\sc2lvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDzeYJ{fGGwdHnhcIx6 NFL6eI8zOjB5OU[wPS=>
SW1783 M1vLSWZ2dmO2aX;uJGF{e2G7 M4\1UFUh|ryP MV6yOEBp MoHoSG1UVw>? NELoN5NKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gd5Vje3SjboTpZYxtgQ>? MoLBNlIxPzl4MEm=
U-373MG NHf2cmxHfW6ldHnvckBCe3OjeR?= MkexOUDPxE1? MXGyOEBp M4nmbmROW09? NF\FdodKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gd5Vje3SjboTpZYxtgQ>? NXzCcHhMOjJyN{m2NFk>
SK-MG3 NXHPOnZnTnWwY4Tpc44hSXO|YYm= NF7EOlY2KM7:TR?= MUiyOEBp NYHhbVlFTE2VTx?= M1uxcWlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDzeYJ{fGGwdHnhcIx6 NF7QUGgzOjB5OU[wPS=>
SU-DHL-5 NXvjXG5OTnWwY4Tpc44hSXO|YYm= NEfh[lgyKM7:TR?= M3XXU|I1KGh? M2X3fmROW09? NFTlXmFKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M3;wVVIxQTV7NkC2
WSU-NHL M1O4dWZ2dmO2aX;uJGF{e2G7 MXWxJO69VQ>? NGr0bZQzPCCq NV:2OFMyTE2VTx?= M4DCT2lv\HWldHnvckBw\iCjcH;weI9{cXN? M2TI[VIxQTV7NkC2
CCRF-SB NF3NbG5HfW6ldHnvckBCe3OjeR?= NHXpe3oyKM7:TR?= NWTK[5ZnOjRiaB?= MXzEUXNQ M1jMcWlv\HWldHnvckBw\iCjcH;weI9{cXN? NEXsSJozODl3OU[wOi=>
INA-6 M3LIXWZ2dmO2aX;uJGF{e2G7 M2f2NFUh|ryP M3vRNVYhcA>? M2rhcGlvcGmkaYTpc44hd2ZiUFmzT{9Cc3RiYX7kJGVTUyCyYYToe4F6 M2Ho[VIxPTB3MUW4
LB NETWcpZHfW6ldHnvckBCe3OjeR?= NIXWdm82KM7:TR?= NIjYfFI3KGh? NHXmbJNKdmirYnn0bY9vKG:oIGDJOGswSWu2IHHu[EBGWkticHH0bJdigQ>? MVuyNFUxPTF3OB?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PUMA / p53 ; 

PubMed: 28008149     


Parental and p53-KD HCT116 cells were treated with 10 μmol/L idelalisib for 24 hours. PUMA expression was analyzed by Western blotting.

Bim / Bcl-xl / Bid / Mcl-1; 

PubMed: 28008149     


HCT116 cells treated with 10 μmol/L idelalisib at indicated time point. The expression of indicated Bcl-2 family members was analyzed by Western blotting.

p-p65; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. p-p65 (S536) and p65 expression was analyzed by Western blotting.

p-AKT / AKT; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. Total AKT and p-AKT expression was analyzed Western blotting.

Cleaved caspase 3 / Cleaved caspase 9; 

PubMed: 28008149     


HepG2 cells were treated with 5μmol/L idelalisib at indicated time point. Cleaved-caspase 3 and 9 were analyzed by western blotting.

Mcl-1 / Bcl-2 / Bid / Bcl-xl / Noxa / Bak / Bax ; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib at indicated time points. The expression of indicated Bcl-2 family members was analyzed by western blotting and normalized to β-actin. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test).

p-FoxO3a / FoxO3a; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib for 24 h. Indicated protein expression was analyzed by western blotting and p-FoxO3a normalized to FoxO3a, p-AKT normalized to AKT. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test). 

Akt(T308) / PDK1(S241) / GSK-3β(S9); 

PubMed: 27342398     


JeKo-1, Mino, and Granta 519 cells or cells from four different MCL patients were serum-starved for 1h and then treated with DMSO, or with 0.5, 1, or 3μM for 1h; the cells were then co-cultured with IgM (10ng/μL) for 15min before harvesting. Cell extracts were prepared, and 30μg (cell lines) or 50μg (primary cells) protein was loaded for immunoblot analyses. The effects of idelalisib on Akt (Thr308) and total Akt, PDK1 (Ser241) and total PDK1, GS3K-3β (Ser9) and total GSK-3β protein expression levels were detected in (A) JeKo-1, Mino and Granta 519 cells.

28008149 30224718 27342398
Growth inhibition assay
Cell viability; 

PubMed: 28008149     


Indicated cell lines were treated with different concentrations of idelalisib for 72 hours. Cell proliferation was determined by MTS assay. Results were expressed as means ± SD of three independent experiments.

Cell viability; 

PubMed: 30224718     


The indicated cell lines were treated with increasing concentrations of idelalisib for 72 h. Cell viability was determined by MTS assay.

28008149 30224718

Protocol

Kinase Assay:[2]
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PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
Cell Research:[2]
- Collapse
  • Cell lines: CLL B cells or healthy volunteer T cells or NK cells
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48 hours
  • Method: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL warmed (199.79 mM)
Water Insoluble
Ethanol '23 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+20%PEG 300+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 415.42
Formula

C22H18FN7O

CAS No. 870281-82-6
Storage powder
in solvent
Synonyms N/A
Smiles CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03582098 Completed Drug: Idelalisib|Drug: Rituximab Chronic Lymphocytic Leukaemia Gilead Sciences September 12 2018 --
NCT03151057 Active not recruiting Drug: Idelalisib 100 MG|Drug: Placebo Oral Tablet B Cells-Tumors|B Cell Chronic Lymphocytic Leukemia|Follicular Lymphoma|Mantle Cell Lymphoma|Large B-Cell Diffuse Lymphoma of Bone (Diagnosis) Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Gilead Sciences July 31 2018 Phase 1
NCT03568929 Recruiting Drug: Idelalisib Follicular Non-Hodgkin''s Lymphoma Refractory Gilead Sciences May 25 2018 --
NCT03310190 Recruiting -- Chronic Lymphocytic Leukemia AbbVie January 10 2018 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • Answer:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. https://www.ncbi.nlm.nih.gov/pubmed/24625684

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID