Idelalisib (CAL-101, GS-1101)

Catalog No.S2226

Idelalisib (CAL-101, GS-1101) Chemical Structure

Molecular Weight(MW): 415.42

Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.

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Cited by 46 Publications

Purity & Quality Control

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Biological Activity

Description Idelalisib (CAL-101, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Targets
p110δ [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
2.5 nM 89 nM
In vitro

CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks FcϵR1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. [1] CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhibit production of inflammatory cytokines, such as IL-6, IL-10, TNF-α, and IFN-γ, and activation-induced cytokines, such as CD40L. CAL-101 also antagonizes CD40L-mediated CLL cell survival. [2] CAL-101 induces an accumulation of cells in G1 and a decrease in the S-phase population in L1236 and L591 cells, which indicates CAL-101 as a novel strategy for the treatment of hodgkin lymphoma (HL). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MEC1 M2HOR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTEUXNQ NHLXOHRKSzVyPUKwMlQh|ryP MnqwNlU6QTl|NUK=
CLL PBMCs MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TGSmROW09? NX74UHNWUUN3ME2yMlkhdk1? M1\rS|I2QTF5Mk[3
U266 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zkO|QxKM7:TR?= NGrBXXQ1QCCq NH:1S|k4QS53JTDpcohq[mm2aX;uJJJifGV? NHXLRW0zPTN|OUOzNi=>
K562 M3XsZmZ2dmO2aX;uJGF{e2G7 MWqxJO69VQ>? MXqzJIg> MXPJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NF[zbpIzPTBzNEe3OS=>
K562 MnTBSpVv[3Srb36gRZN{[Xl? MVixJO69VQ>? M{nr[lMhcA>? NUTNPJV3UW6qaXLpeIlwdiCxZjDQO|BUPkticHjvd5Bpd3K7bHH0bY9v MmT0NlUxOTR5N{W=
K562 MXfGeY5kfGmxbjDBd5NigQ>? MYOxJO69VQ>? M4S5PFMhcA>? NETtN3NKdmirYnn0bY9vKG:oIFfTT|MheGixc4Doc5J6dGG2aX;u MUWyOVAyPDd5NR?=
K562 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17SXlEh|ryP MkL6O|IhcA>? MUPJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36= NYO2[pNnOjVyMUS3O|U>
Primary AML cell M3TjR2Z2dmO2aX;uJGF{e2G7 M4fpNFEh|ryP MXuzJIg> MXrJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NGC5UZAzPTBzNEe3OS=>
Primary AML cell NG\wTVlHfW6ldHnvckBCe3OjeR?= MYmxJO69VQ>? NXHP[mZmOyCq MYLJcohq[mm2aX;uJI9nKFB5MGO2T{BxcG:|cHjvdplt[XSrb36= NYrFU2ZVOjVyMUS3O|U>
Primary AML cell MY\GeY5kfGmxbjDBd5NigQ>? NWOxTlNxOSEQvF2= NVLzOGs5OyCq MnOzTY5pcWKrdHnvckBw\iCJU1uzJJBpd3OyaH;yfYxifGmxbh?= MViyOVAyPDd5NR?=
Primary AML cell MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[4PItHOSEQvF2= NGrPR4Q{KGh? NFHORYNUfXCycnXzd4lwdiCxZjDyVm5CKHO7boTo[ZNqew>? MU[yOVAyPDd5NR?=
Microglia NWPDW5A2TnWwY4Tpc44hSXO|YYm= MnfDOUDPxE1? Mm\JNVAhcA>? NVXDeYp1TE2VTx?= NF3QVlhF\WO{ZXHz[UBw\iCWTl\hJJNm[3KndHnvckBnem:vIFzQV{1{fGmvdXzheIVlKCCyMUGw{tRFQTFyQT;EPVExSSCvaXPyc4dtcWF? M3vKPFI1PjJ3Nki0
Primary CLL cell MU\GeY5kfGmxbjDBd5NigQ>? NUXsOmlSOSEQvF2= MoGzNVUhdWmw MXPEUXNQ MVnCcI9kc3NiQlPSMYlv\HWlZXSgUGNROSC|ZYLpcoUuPSCjY4TpeoF1cW:w MofmNlQxODl{M{O=
JEKO-1 MVzGeY5kfGmxbjDBd5NigQ>? NVrJSJI6OSEQvF2= M17KdVczKGh? M2PqXmlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbjDpckBK\01vc4TpcZVt[XSnZDDKSWtQNTF? MYOyN|M1OTV2MR?=
Granta-519 NYjQcGp2TnWwY4Tpc44hSXO|YYm= MW[xJO69VQ>? MnXnNkBp MXzJcohq[mm2aX;uJI9nKEGtdDj0N|A5MSCyaH;zdIhwenmuYYTpc44> M2CydFI{OzRzNUSx
Granta-519 MVTGeY5kfGmxbjDBd5NigQ>? MV2xJO69VQ>? M3j4U|IhcA>? M1vPdWlvcGmkaYTpc44hd2ZiQXv0LJM1PzNrIIDoc5NxcG:{eXzheIlwdg>? M3X0d|I{OzRzNUSx
JEKO-1 NFTHboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGxNEDPxE1? M1m2TFczKGh? NVHoeYF2UW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKHOuaXfoeIx6 M3HiUlI{OzRzNUSx
JEKO-1 MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUe1JO69VQ>? M3XrNVczKGh? NGS0dnNld2W|IH7veEBqdmS3Y3WgZ4VtdCCleXPs[UBienKnc4Sgc5Ih[XCxcITvd4l{ M1;3eVI{Pjd4MkKw
MAVER-1 M2PpOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYW1JO69VQ>? NFjMUFE4OiCq Mlna[I9meyCwb4SgbY5lfWOnIHPlcIwh[3mlbHWgZZJz\XO2IH;yJIFxd3C2b4Ppdy=> Ml3pNlM3PzZ{MkC=
MINO NYTDOWp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUS1JO69VQ>? M2HDR|czKGh? NYm1UmJP\G:nczDuc5QhcW6mdXPlJINmdGxiY4njcIUh[XK{ZYP0JI9zKGGyb4D0c5Nqew>? NWXGXm1HOjN4N{[yNlA>
SP53 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGzNY8xNjFizszN NHPObHc4OiCq MUTkc4V{KG6xdDDpcoR2[2ViY3XscEBkgWOuZTDhdpJme3Rib4KgZZBweHSxc3nz MkG3NlM3PzZ{MkC=
HH NGHHTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP2T3kyOCEQvF2= Mk\zO|IhcA>? MoXzSG1UVw>? NUTUUlBLUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDzcIlocHSueR?= NFrDZmEzOjhyMUm1PS=>
Myla MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm2UY5yOTBizszN M{W3e|czKGh? NWfLblBQTE2VTx?= MlrI[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= MV:yNlgxOTl3OR?=
SR786 NYHtWVlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXwd|lEOTBizszN MmizO|IhcA>? MlLsSG1UVw>? MkPh[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= M1TyOVIzQDBzOUW5
HuT78 Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ESFZZOTBizszN M3zUfVczKGh? MXnEUXNQ NETXfplld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nz MojhNlI5ODF7NUm=
MJ NGToPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDTc25EOTBizszN MorHO|IhcA>? M37Ve2ROW09? Mlvj[I9meyCwb4SgbY5lfWOnIHHwc5B1d3Orcx?= MVGyNlgxOTl3OR?=
DERL7 MkW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOxNEDPxE1? MoX4O|IhcA>? NEfrPFBFVVOR M1LqNYRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYO= NX3pNIJQOjJ6MEG5OVk>
L1236 NGXCeXlHfW6ldHnvckBCe3OjeR?= MY[xNEDPxE1? M4ruZ|IhcA>? MUjJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25? NVrrWpRmOjJ{MUC4O|c>
L428 MX3GeY5kfGmxbjDBd5NigQ>? M{PSelExKM7:TR?= NX\NRZpQOiCq M{HVPWlvcGmkaYTpc44hd2ZiQXv0JJBpd3OyaH;yfYxifGmxbh?= MYSyNlIyODh5Nx?=
L591 MoXrSpVv[3Srb36gRZN{[Xl? NH[0fIYyOCEQvF2= NWTzN285OiCq NHjnOVZKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36= M4HQOlIzOjFyOEe3
KMH-2 MlKxSpVv[3Srb36gRZN{[Xl? NWTYSVNmOTBizszN NWnKZnk1OiCq NWPBeZZyUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;u M1fMNlIzOjFyOEe3
L1236 NYf5V3dnTnWwY4Tpc44hSXO|YYm= M1;oR|Uh|ryP NYLpZ5hWOjRiaB?= NV6zdmRsSmyxY3vzJJNm[3KndHnvckBw\iC2aHWgR2NNPQ>? NYLr[ZRvOjJ{MUC4O|c>
L591 NYnjWpdnTnWwY4Tpc44hSXO|YYm= MW[1JO69VQ>? NXq5TlZOOjRiaB?= MXXCcI9kc3Nic3XjdoV1cW:wIH;mJJRp\SCFQ1y1 MlH0NlIzOTB6N{e=
L1236 NYfETmpzSXCxcITvd4l{KEG|c3H5 MV:1JO69VQ>? NWjXUY9zOjRiaB?= M1zIN2lv\HWldHnvckBw\iCjcH;weI9{cXN? NXfSZYpKOjJ{MUC4O|c>
L591 MUDBdI9xfG:|aYOgRZN{[Xl? Mm\pOUDPxE1? NXHrc21JOjRiaB?= M{LK[Wlv\HWldHnvckBw\iCjcH;weI9{cXN? NGHSNowzOjJzMEi3Oy=>
U-87MG MWfGeY5kfGmxbjDBd5NigQ>? NEfDcocyODBibl2= MX[yOEBp NGrHTlNFVVOR MYXJcohq[mm2aX;uJI9nKCClZXzsJI1q\3KjdHnvci=> NIjnU5kzOjB5OU[wPS=>
SW1783 NHnVV29HfW6ldHnvckBCe3OjeR?= MV2xNFAhdk1? NYTtZ2lXOjRiaB?= MmTTSG1UVw>? MXPJcohq[mm2aX;uJI9nKCClZXzsJI1q\3KjdHnvci=> M{jEOlIzODd7NkC5
U-87MG MnPiSpVv[3Srb36gRZN{[Xl? Mn\IOUDPxE1? NIDuc2YzPCCq MW\EUXNQ NIXROlBKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gd5Vje3SjboTpZYxtgQ>? MUeyNlA4QTZyOR?=
SW1783 MXPGeY5kfGmxbjDBd5NigQ>? MXe1JO69VQ>? NXH1[FVmOjRiaB?= NGLmT3ZFVVOR MnvITY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> MUiyNlA4QTZyOR?=
U-373MG NV\wXotlTnWwY4Tpc44hSXO|YYm= NVX3[GVlPSEQvF2= NHziRY8zPCCq NGPDXHdFVVOR MmfJTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIIP1ZpN1[W62aXHscJk> NH\qVVYzOjB5OU[wPS=>
SK-MG3 M3nac2Z2dmO2aX;uJGF{e2G7 M2f4cVUh|ryP M3LpWFI1KGh? MmfvSG1UVw>? NGrLWppKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gd5Vje3SjboTpZYxtgQ>? NILZZZgzOjB5OU[wPS=>
SU-DHL-5 MXrGeY5kfGmxbjDBd5NigQ>? NYjQV3V4OSEQvF2= M3T6cVI1KGh? NGLuN3pFVVOR NUDmWldVUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?= M3ztUVIxQTV7NkC2
WSU-NHL MnLkSpVv[3Srb36gRZN{[Xl? MUSxJO69VQ>? MlT3NlQhcA>? NEX6RWpFVVOR NIfrc29KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| MmnqNlA6PTl4ME[=
CCRF-SB MVPGeY5kfGmxbjDBd5NigQ>? NHzh[XUyKM7:TR?= M{\tcVI1KGh? M2rWfWROW09? MoruTY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>? MWSyNFk2QTZyNh?=
INA-6 NFjCVmxHfW6ldHnvckBCe3OjeR?= MWi1JO69VQ>? M1j3O|YhcA>? MmjxTY5pcWKrdHnvckBw\iCSSUPLM2FsfCCjbnSgSXJMKHCjdHj3ZZk> MUiyNFUxPTF3OB?=
LB NETZbnRHfW6ldHnvckBCe3OjeR?= NXLB[2FpPSEQvF2= MYG2JIg> M3HMeGlvcGmkaYTpc44hd2ZiUFm0T{9Cc3RiYX7kJGVTUyCyYYToe4F6 MoP2NlA2ODVzNUi=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PUMA / p53 ; 

PubMed: 28008149     


Parental and p53-KD HCT116 cells were treated with 10 μmol/L idelalisib for 24 hours. PUMA expression was analyzed by Western blotting.

Bim / Bcl-xl / Bid / Mcl-1; 

PubMed: 28008149     


HCT116 cells treated with 10 μmol/L idelalisib at indicated time point. The expression of indicated Bcl-2 family members was analyzed by Western blotting.

p-p65; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. p-p65 (S536) and p65 expression was analyzed by Western blotting.

p-AKT / AKT; 

PubMed: 28008149     


HCT116 cells were treated with 10 μmol/L idelalisib at indicated time point. Total AKT and p-AKT expression was analyzed Western blotting.

Cleaved caspase 3 / Cleaved caspase 9; 

PubMed: 28008149     


HepG2 cells were treated with 5μmol/L idelalisib at indicated time point. Cleaved-caspase 3 and 9 were analyzed by western blotting.

Mcl-1 / Bcl-2 / Bid / Bcl-xl / Noxa / Bak / Bax ; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib at indicated time points. The expression of indicated Bcl-2 family members was analyzed by western blotting and normalized to β-actin. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test).

p-FoxO3a / FoxO3a; 

PubMed: 30224718     


HepG2 cells were treated with 5 μmol/L idelalisib for 24 h. Indicated protein expression was analyzed by western blotting and p-FoxO3a normalized to FoxO3a, p-AKT normalized to AKT. The data represent the mean ± SD of three independent experiments. **P < 0.01 (one-way ANOVA with Tukey’s post hoc test). 

Akt(T308) / PDK1(S241) / GSK-3β(S9); 

PubMed: 27342398     


JeKo-1, Mino, and Granta 519 cells or cells from four different MCL patients were serum-starved for 1h and then treated with DMSO, or with 0.5, 1, or 3μM for 1h; the cells were then co-cultured with IgM (10ng/μL) for 15min before harvesting. Cell extracts were prepared, and 30μg (cell lines) or 50μg (primary cells) protein was loaded for immunoblot analyses. The effects of idelalisib on Akt (Thr308) and total Akt, PDK1 (Ser241) and total PDK1, GS3K-3β (Ser9) and total GSK-3β protein expression levels were detected in (A) JeKo-1, Mino and Granta 519 cells.

28008149 30224718 27342398
Growth inhibition assay
Cell viability; 

PubMed: 28008149     


Indicated cell lines were treated with different concentrations of idelalisib for 72 hours. Cell proliferation was determined by MTS assay. Results were expressed as means ± SD of three independent experiments.

Cell viability; 

PubMed: 30224718     


The indicated cell lines were treated with increasing concentrations of idelalisib for 72 h. Cell viability was determined by MTS assay.

28008149 30224718

Protocol

Kinase Assay:[2]
+ Expand

PI3K assay:

PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.
Cell Research:[2]
+ Expand
  • Cell lines: CLL B cells or healthy volunteer T cells or NK cells
  • Concentrations: 0.01-100 μM
  • Incubation Time: 48 hours
  • Method: MTT assays are performed to determine cytotoxicity. 1 × 105 cells are incubated with CAL-101. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. DMSO is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed. At least 104 cells are counted for each sample. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis included the addition of 100 μM Z-VAD. Experiments examining survival signals include the addition of 1 μg/mL CD40L, 800 U/mL IL-4, 50 ng/mL BAFF, 20 ng/mL TNF-α, or coculturing on fibronectin or stromal (HS-5 cell line) coated plates. Stromal coculture is done by plating a 75-cm2 flask (80%-100% confluent) per 6-well plate 24 hours before the addition of CLL cells.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL warmed (199.79 mM)
Ethanol 23 mg/mL (55.36 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG 400 (dissolve first)+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 415.42
Formula

C22H18FN7O

CAS No. 870281-82-6
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03349346 Withdrawn Diffuse Large B-Cell Lymphoma|Mediastinal B-cell Lymphoma Gilead Sciences June 2019 Phase 1
NCT03349346 Withdrawn Diffuse Large B-Cell Lymphoma|Mediastinal B-cell Lymphoma Gilead Sciences June 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03639324 Not yet recruiting Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University March 30 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03639324 Not yet recruiting Chronic Lymphocytic Leukemia|CLL|Relapsed CLL|Refractory Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphocytic Leukemia Virginia Commonwealth University March 30 2019 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    What is the recommended dose of CAL-101 and the route of administration for mouse studies?

  • Answer:

    According to the following paper, S2226 can be used by I.V. administration at the concentration of 40 mg/kg. https://www.ncbi.nlm.nih.gov/pubmed/24625684

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID