4-Phenylbutyric acid (4-PBA)

For research use only.

Catalog No.S3592 Synonyms: Benzenebutyric acid

3 publications

4-Phenylbutyric acid (4-PBA) Chemical Structure

CAS No. 1821-12-1

4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

Selleck's 4-Phenylbutyric acid (4-PBA) has been cited by 3 publications

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Biological Activity

Description 4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
Targets
HDAC [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 33 mg/mL (200.97 mM)
Water Insoluble
Ethanol ''33 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 164.20
Formula

C10H12O2

CAS No. 1821-12-1
Storage powder
in solvent
Synonyms Benzenebutyric acid

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID