Home DNA Damage/DNA Repair HDAC inhibitor - Autophagy modulator 4-PBA (4-Phenylbutyric acid) For research use only.

4-PBA (4-Phenylbutyric acid)

Synonyms: Benzenebutyric acid

4-PBA (4-Phenylbutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

4-PBA (4-Phenylbutyric acid) Chemical Structure

4-PBA (4-Phenylbutyric acid) Chemical Structure

CAS: 1821-12-1

Selleck's 4-PBA (4-Phenylbutyric acid) has been cited by 14 publications

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description 4-PBA (4-Phenylbutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
Targets
HDAC [1]
In vitro
In vitro

4-PBA inhibits the ER stress induced by SiNPs in RAW264.7 cells, as evidenced by the expansion and degranulation of ER, as well as greatly up-regulated Bip and CHOP expressions.[3]
Cell Research Cell lines Mouse macrophage cell line, RAW264.7 cells
Concentrations 3 mM
Incubation Time 6 h
Method

Mouse macrophage cell line, RAW264.7 cells are cultured in DMEM with 10% fetal bovine serum at 37 ℃ in a 5% CO2 incubator. SiNPs are diluted by DMEM to appropriate concentrations, and an ER stress inhibitor, 4-phenylbutyric acid (4-PBA) is applied (3 mM, 6 h). The SiNPs-treated group is at a concentration of 50 μg/ml in vitro experiments. Similarly, the application of 4-PBA is set up through MTT assay, after SiNPs with or without 4-PBA treatment, cells are harvested for the following measurement. The levels of Bip and CHOP induced by SiNPs are measured.
In Vivo
In vivo

4-PBA attenuates LPS-induced bone loss in lipopolysaccharide (LPS)-treated mice, by increasing area of TRAP-positive osteoclasts (OCs) and serum level of collagen type I fragments.[4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00067756 Completed
Alpha 1-Antitrypsin Deficiency
University of Florida|Alpha-1 Foundation|Brantly Mark L. M.D.
 November 2001 Phase 2

Chemical Information & Solubility

Molecular Weight 164.20 Formula

C10H12O2
CAS No. 1821-12-1 SDF --
Smiles OC(=O)CCCC1=CC=CC=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 33 mg/mL ( (200.97 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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