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ULK-101 ULK1 Inhibitor

Name: ULK-101
Brand: Selleck Chemicals
SKU: S8793
Availability: InStock
Rating: 5 (15 reviews)

Cat.No.S8793

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

Chemical Structure

Molecular Weight: 460.45

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Quality Control

Batch: S879301 DMSO]92 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.96%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.96

Related Targets	CXCR Autophagy Nrf2 Mitophagy LRRK2 FKBP Heme Oxygenase cGAS LC3 Cell wall
Other ULK Inhibitors	MRT68921 HCl SBI-0206965 LYN-1604 XST-14 BL-918 SBP-7455 DCC-3116

Solubility

In vitro
Batch:

DMSO : 92 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	460.45	Formula	C₂₂H₁₆F₄N₄OS	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2443816-45-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	FC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CSC(=C4)C(=O)NC(C5CC5)C(F)(F)F

Mechanism of Action

Targets/IC₅₀/Ki	ULK1 (Cell-free assay) 8.3 nM ULK2 (Cell-free assay) 30 nM
In vitro	ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. This compound sensitizes KRAS mutant lung cancer cells to nutrient stress.
References	[1] https://pubmed.ncbi.nlm.nih.gov/30292171/

Tech Support

Handling Instructions

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