Home Autophagy ULK inhibitor - Autophagy inhibitor ULK-101 For research use only.

ULK-101

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

ULK-101 Chemical Structure

ULK-101 Chemical Structure

CAS: 2443816-45-1

Selleck's ULK-101 has been cited by 14 publications

Purity & Quality Control

Batch: S879301 DMSO] 92 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.96%
99.96

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Biological Activity

Description ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
Targets
ULK1 [1]
(Cell-free assay)		 ULK2 [1]
(Cell-free assay)
8.3 nM 30 nM
In vitro
In vitro

ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress[1].
Cell Research Cell lines U2OS cells
Concentrations 5 μM
Incubation Time 2.5 h
Method

U2OS cells stably expressing EGFP-DFCP1 are treated for 2.5 hr with vehicle control or 100 nM AZD8055 with or without 5 μM ULK-101 and imaged live by fluorescent microscopy.

Chemical Information & Solubility

Molecular Weight 460.45 Formula

C22H16F4N4OS
CAS No. 2443816-45-1 SDF --
Smiles FC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CSC(=C4)C(=O)NC(C5CC5)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (199.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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