ULK-101

Catalog No.S8793

ULK-101 Chemical Structure

Molecular Weight(MW): 460.45

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

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USD 217 In stock
USD 470 In stock
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Purity & Quality Control

Choose Selective Autophagy Inhibitors

Biological Activity

Description ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
Targets
ULK1 [1]
(Cell-free assay)
ULK2 [1]
(Cell-free assay)
8.3 nM 30 nM
In vitro

ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: U2OS cells
  • Concentrations: 5 μM
  • Incubation Time: 2.5 h
  • Method:

    U2OS cells stably expressing EGFP-DFCP1 are treated for 2.5 hr with vehicle control or 100 nM AZD8055 with or without 5 μM ULK-101 and imaged live by fluorescent microscopy.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 92 mg/mL (199.8 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 460.45
Formula

C22H16F4N4OS

CAS No. no cas
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID