ULK-101

Catalog No.S8793

For research use only.

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

ULK-101 Chemical Structure

CAS No. 2443816-45-1

Selleck's ULK-101 has been cited by 8 Publications

Purity & Quality Control

Choose Selective ULK Inhibitors

Biological Activity

Description ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
Targets
ULK1 [1]
(Cell-free assay)
ULK2 [1]
(Cell-free assay)
8.3 nM 30 nM
In vitro

ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: U2OS cells
  • Concentrations: 5 μM
  • Incubation Time: 2.5 h
  • Method:

    U2OS cells stably expressing EGFP-DFCP1 are treated for 2.5 hr with vehicle control or 100 nM AZD8055 with or without 5 μM ULK-101 and imaged live by fluorescent microscopy.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 460.45
Formula

C22H16F4N4OS

CAS No. 2443816-45-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles FC1=CC=C(C=C1)C2=C[N]3N=CC(=C3N=C2)C4=CSC(=C4)C(=O)NC(C5CC5)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy ULK-101 | ULK-101 supplier | purchase ULK-101 | ULK-101 cost | ULK-101 manufacturer | order ULK-101 | ULK-101 distributor