Paclitaxel (NSC 125973)

For research use only.

Catalog No.S1150 Synonyms: PTX, Taxol, Onxal, Abraxane

245 publications

Paclitaxel (NSC 125973) Chemical Structure

CAS No. 33069-62-4

Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

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Selleck's Paclitaxel (NSC 125973) has been cited by 245 publications

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Biological Activity

Description Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Targets
Microtubule (human endothelial cells) [1]
0.1 pM
In vitro

Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. [1] In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. [2] Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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KASUMI-1 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjoTWM2OCB;IEKzMlUyOTlizszN M{exRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
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NH-12 NWjHU4J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX:yOppZUUN3MDC9JFI1NjF4NUSg{txO NVzUXXNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
WSU-NHL NVfBbJRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3yPVFKSzVyIE2gNlUvPzJ4MTFOwG0> M1vtSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
TUR NEDFOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLXcVNlUUN3MDC9JFI3NjZ3M{Og{txO M1H5dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
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EW-12 NIL3d2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq4TWM2OCB;IEK4MlA4ODJizszN M2jHN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
KG-1 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4CxRWlEPTBiPTCyPE4zQDZ3IN88US=> Mnn4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
P31-FUJ NHzvNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnLTZpKSzVyIE2gNlkvODR6OTFOwG0> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
NB10 M2PKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxKD1iM{GuOVA6KM7:TR?= NX7QbJN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
COLO205 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NImzcWVIUTVyIE2gNE4xODF5NjFOwG0> NYD2Tm5KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
SF539 NXjMO4VwS3m2b4TvfIlkcXS7IHHzd4F6 MUHHTVUxKD1iMD6wNFM3PiEQvF2= MmmxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzlyOEm1NEc,PzlyOEm1NFww[T5?
SNB75 MlXhR5l1d3SxeHnjbZR6KGG|c3H5 NXztTpJ4T0l3MDC9JFAvODB6MEig{txO M3nDSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd7MEi5OVAoRjd7MEi5OVA9N2F-
DMS114 NYrNTFlLS3m2b4TvfIlkcXS7IHHzd4F6 MV;HTVUxKD1iMD6wNVI{KM7:TR?= NHLzNIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
OVCAR-3 M2C1UmN6fG:2b4jpZ4l1gSCjc4PhfS=> NULH[ZZyT0l3MDC9JFAvODF7NzFOwG0> NGG3bXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
NCI-H460 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NILDfnlIUTVyIE2gNE4xOjF7IN88US=> M1nwSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd7MEi5OVAoRjd7MEi5OVA9N2F-
HOP62 NUPtVnlJS3m2b4TvfIlkcXS7IHHzd4F6 M1HZO2dKPTBiPTCwMlA3PzFizszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
mammary carcinoma NW\CdVhTS3m2b4TvfIlkcXS7IHHzd4F6 Ml22TWM2OCB;IECuNlk6KM7:TR?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85OTh{Nkm4K|45OTh{Nkm4QE9iRg>?
NCI60 MWfDfZRwfG:6aXPpeJkh[XO|YYm= M3L0XWdKPTBiPTCwMlAxODZ3IN88US=> M1LlfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl2NkG2OVMoRjl2NkG2OVM9N2F-
MCF-7 MoLJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHHTVUxKD1iMD6wNFEyKM7:TR?= NXz5S4RPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3N|U6Pyd-OUi3N|U6PzxxYU6=
murine leukemic P388 MlT5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV7HTVUxKD1iMD6wNVYh|ryP MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDd|NUm3K|46QDd|NUm3QE9iRg>?
KB M{S3RmN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml74TWM2OCB;IECuNFA3KM7:TR?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODl5OEKwNEc,OTB7N{iyNFA9N2F-
MCF7 NWfxfms3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXrnS2xxPzJiaB?= MWHJR|UxKD1iMD6wNFIh|ryP M4rwRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzM{K1NlI3Lz5zMUOyOVIzPjxxYU6=
MCF-7 MXTDfZRwfG:6aXPpeJkh[XO|YYm= MUHFSFUxKD1iMD6wNFQh|ryP NEfRdIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUOzOFU3Pyd-MUGzN|Q2Pjd:L3G+
uterine sarcoma (MES-SA) MknLR5l1d3SxeHnjbZR6KGG|c3H5 NITYfJhKSzVyIE2gNE4xODByNDFOwG0> MlS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5MkixPVEoRjFzN{K4NVkyRC:jPh?=
nonsmall cell lung carcinoma (NCI-H460) M2XXNmN6fG:2b4jpZ4l1gSCjc4PhfS=> MofMTWM2OCB;IECuNFAxOTRizszN NF;IOoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUeyPFE6OSd-MUG3NlgyQTF:L3G+
colon adenocarcinoma (HT-29) NXW3Rnc4S3m2b4TvfIlkcXS7IHHzd4F6 M3nWVGlEPTBiPTCwMlAxODF4IN88US=> NW\LTXZqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3NlgyQTFpPkGxO|I5OTlzPD;hQi=>
prostate carcinoma (DU-145) MlG0R5l1d3SxeHnjbZR6KGG|c3H5 MV;JR|UxKD1iMD6wNFQ5QSEQvF2= NFrKNnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUeyPFE6OSd-MUG3NlgyQTF:L3G+
SW626 MX\DfZRwfG:6aXPpeJkh[XO|YYm= MUi3NkBp M1rPZWlEPTBiPTCwMlAxODBzIN88US=> NEPkfGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
Lu1 NVz3WmNrS3m2b4TvfIlkcXS7IHHzd4F6 MXW3NkBp M{TOUWlEPTBiPTCwMlAyKM7:TR?= M3\mOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
MCF7 NF7ifGpEgXSxdH;4bYNqfHliYYPzZZk> NFv1N4Q4OiCq MXTJR|UxKD1iMD6wNkDPxE1? MonVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
P388 M3WxZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> NX3LUmRzPzJiaB?= M{HBUWlEPTBiPTCwMlAzKM7:TR?= M3fjWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
LNCAP MV7DfZRwfG:6aXPpeJkh[XO|YYm= Mlm1O|IhcA>? MlzuTWM2OCB;IECuNFIh|ryP NVjvdIdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
KB NIK2V4FEgXSxdH;4bYNqfHliYYPzZZk> Mlu2O|IhcA>? M{\ZXGlEPTBiPTCwMlAzKM7:TR?= NEi5fWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
Col2 MWjDfZRwfG:6aXPpeJkh[XO|YYm= MoKzO|IhcA>? MmDyTWM2OCB;IECuNFIh|ryP Mm\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
BC1 MWPDfZRwfG:6aXPpeJkh[XO|YYm= M{XPSlczKGh? MnrLTWM2OCB;IECuNFIh|ryP M3nXNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
SK-MEL-2 MmT3R5l1d3SxeHnjbZR6KGG|c3H5 M2DpUFczKGh? M{\hNWlEPTBiPTCwMlA4KM7:TR?= NVTyfWV3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwPFg1OjVpPkGyNFg5PDJ3PD;hQi=>
L2987 MYXDfZRwfG:6aXPpeJkh[XO|YYm= M3XCdmlEPTBiPTCwMlIh|ryP NF2xTYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkS0N|c5Oyd-MUK0OFM4QDN:L3G+
colon adenocarcinoma RKO MlXVR5l1d3SxeHnjbZR6KGG|c3H5 Mn3TTWM2OCB;IECuNFEh|ryP M3jRUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyO|Y5Lz5zMki1Nlc3QDxxYU6=
NCI-H460 NYrMbFVES3m2b4TvfIlkcXS7IHHzd4F6 M1jqe|Q5KGh? MYnJR|UxKD1iMD6wNFk2KM7:TR?= NUfjb3kyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2PVU4QThpPkG0Olk2Pzl6PD;hQi=>
MCF7 M{\ZRmN6fG:2b4jpZ4l1gSCjc4PhfS=> M{nxNlQ5KGh? M3zyXmlEPTBiPTCwMlAyOTJizszN NVq2R|M5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2PVU4QThpPkG0Olk2Pzl6PD;hQi=>
SF268 MVfDfZRwfG:6aXPpeJkh[XO|YYm= NGOycHk1QCCq NEDy[pRKSzVyIE2gNE4xOjF5IN88US=> NWjxdHYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS2PVU4QThpPkG0Olk2Pzl6PD;hQi=>
MDA-MB-231 M1WxW2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVS0PEBp M17KVWlEPTBiPTCwMlAxPDVizszN NX;ieWFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTFpPkG0PVg4ODVzPD;hQi=>
MCF7 MojyR5l1d3SxeHnjbZR6KGG|c3H5 NILy[VM1QCCq MmT1TWM2OCB;IECuNFA1QSEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1NUc,OTR7OEewOVE9N2F-
A2780 NXrPcIs2S3m2b4TvfIlkcXS7IHHzd4F6 Mmq2OFghcA>? MX3JR|UxKD1iMD6wNlUh|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1NUc,OTR7OEewOVE9N2F-
PC3 MnzqR5l1d3SxeHnjbZR6KGG|c3H5 MWO0PEBp NH70ZpRKSzVyIE2gNE4xPzdizszN NWTlPGRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTFpPkG0PVg4ODVzPD;hQi=>
MCF7 Mon4R5l1d3SxeHnjbZR6KGG|c3H5 M1rId|czKGh? NUHXWmVJUUN3MDC9JFAvODBzNDFOwG0> NYCyVIh6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTZpPkG0PVg4ODV4PD;hQi=>
multidrug-resistant MCF7 NGXUfZZEgXSxdH;4bYNqfHliYYPzZZk> NW\PUJMxPzJiaB?= MX;JR|UxKD1iMD6zOVQh|ryP NXjhNJh1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTZpPkG0PVg4ODV4PD;hQi=>
PC3 MnHUR5l1d3SxeHnjbZR6KGG|c3H5 MmfZOFghcA>? NV\vdnBiUUN3MDC9JFAvODF4IN88US=> MmjlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFIoRjF3MESzOFAzRC:jPh?=
Hep3B MYXDfZRwfG:6aXPpeJkh[XO|YYm= NIXiUmM1QCCq MlfSTWM2OCB;IECuNFMyKM7:TR?= M3fRXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFAzLz5zNUC0N|QxOjxxYU6=
NCI-H460 MkDHR5l1d3SxeHnjbZR6KGG|c3H5 MVe0PEBp MXPJR|UxKD1iMD6wNFk2KM7:TR?= M3XvVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA1Lz5zNUC0N|QxPDxxYU6=
MCF7 NFnwZmlEgXSxdH;4bYNqfHliYYPzZZk> MlPsOFghcA>? MWLJR|UxKD1iMD6wNVEzKM7:TR?= NGfkSFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPCd-MUWwOFM1ODR:L3G+
SF268 M1LFVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnPIOFghcA>? Mo\qTWM2OCB;IECuNFIyPyEQvF2= MnHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFQoRjF3MESzOFA1RC:jPh?=
KB NUOweoI4S3m2b4TvfIlkcXS7IHHzd4F6 MnHESWQ2OCB;IECuNFAxPCEQvF2= NWrmPGo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
Lu1 NGno[JREgXSxdH;4bYNqfHliYYPzZZk> MU\FSFUxKD1iMD6wNFIh|ryP NWfJPJJyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
LNCAP M4roe2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXPaZoRqTUR3MDC9JFAvODB3IN88US=> M{LIVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
RPE1 M{OzNmN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml\mSWQ2OCB;IECuNFI{KM7:TR?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTB2M{SwO{c,OTVyNEO0NFc9N2F-
Col2 MlL3R5l1d3SxeHnjbZR6KGG|c3H5 M2qzemVFPTBiPTCwMlA1PiEQvF2= MkDIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
T47D MVjBdI9xfG:|aYOgZZN{[Xl? NWPHUZFUOjRiaB?= NGm0bW1GSzVyIE2gNE4xOyEQvF2= MlvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3Nk[zNFAoRjF3NU[2N|AxRC:jPh?=
DLD1 MnjQRZBweHSxc3nzJIF{e2G7 MkHSNlQhcA>? NIHTSIJGSzVyIE2gNE4xPzVizszN M4LrblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NU[2N|AxLz5zNUW2OlMxODxxYU6=
H1299 M3n1V2Fxd3C2b4Ppd{Bie3OjeR?= NFXzUIozPCCq Mm[0SWM2OCB;IECuNVY{KM7:TR?= M4HEZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NU[2N|AxLz5zNUW2OlMxODxxYU6=
VA13 MX7DfZRwfG:6aXPpeJkh[XO|YYm= MnLKOFghcA>? MkXWTWM2OCB;IECuNFA2KM7:TR?= M1nhb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{OwNlQ{Lz5zNUezNFI1OzxxYU6=
WI 38 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MXG0PEBp NIDoeZNKSzVyIE2gNE4xPCEQvF2= NWTw[IlIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3N|AzPDNpPkG1O|MxOjR|PD;hQi=>
Hep G2 NGe0U4hEgXSxdH;4bYNqfHliYYPzZZk> M4i5ZVQ5KGh? M330NmlEPTBiPTC4MlEh|ryP Mnv1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5M{CyOFMoRjF3N{OwNlQ{RC:jPh?=
A549 M4WxcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkXBOFghcA>? NYjFZ2tiUUN3MDC9JFEvOjVizszN MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd6N{S2NEc,OTV5OEe0OlA9N2F-
SKOV3 NXnjO|gzS3m2b4TvfIlkcXS7IHHzd4F6 M1\0eFQ5KGh? NFrtTYRKSzVyIE2gNU4{PSEQvF2= MnHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5OEe0OlAoRjF3N{i3OFYxRC:jPh?=
KB NEjiVoREgXSxdH;4bYNqfHliYYPzZZk> NYSxZXNQOyCmYYnz M1;NdmlEPTBiPTCwMlAxOSEQvF2= M13NfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEO4OVQ2Lz5zNkCzPFU1PTxxYU6=
1A9 NXG4OFkxS3m2b4TvfIlkcXS7IHHzd4F6 NW\MOIZJOyCmYYnz NVy4cnBRUUN3MDC9JFAvODB{IN88US=> MmXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZyM{i1OFUoRjF4MEO4OVQ2RC:jPh?=
HCT8 NWSzVHNvS3m2b4TvfIlkcXS7IHHzd4F6 MnOyN{Bl[Xm| M360N2lEPTBiPTCwMlAyOyEQvF2= M3rXZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEO4OVQ2Lz5zNkCzPFU1PTxxYU6=
A431 M{nrbmNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 MVzFR|UxKD1iMD6wNFkh|ryP M3z5d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{e3NVg4Lz5zNkO3O|E5PzxxYU6=
VA13 NIHWN3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUi0PEBp NWrS[nR5UUN3MDC9JFAvODB2MzFOwG0> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjR7OUOyNkc,OTZ2OUmzNlI9N2F-
WI38 NYfFRnY5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2nXPVQ5KGh? NIDiU3dKSzVyIE2gNE4xOzRizszN NEHzV5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkS5PVMzOid-MU[0PVk{OjJ:L3G+
HepG2 MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1XBT|Q5KGh? MlL1TWM2OCB;IE[uPUDPxE1? NWj4XoZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0PVk{OjJpPkG2OFk6OzJ{PD;hQi=>
Aro NHTVNHZEgXSxdH;4bYNqfHliYYPzZZk> NULET4VHUUN3MDC9JFAvODByMjFOwG0> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
PT45 Mo[4R5l1d3SxeHnjbZR6KGG|c3H5 Ml;LTWM2OCB;IECuNFA2KM7:TR?= NFTFWpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
A549 NUjTRodKS3m2b4TvfIlkcXS7IHHzd4F6 M1TOSGlEPTBiPTCwMlAxPiEQvF2= NYC3PXd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
MCF7 NVv6fIhwS3m2b4TvfIlkcXS7IHHzd4F6 NYTFNnJlUUN3MDC9JFAvODB5IN88US=> M1HTZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
HeLa NIGyb3VEgXSxdH;4bYNqfHliYYPzZZk> M2TIUGlEPTBiPTCwMlAxQCEQvF2= M{Hpc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
Ovcar3 NEf3O3JEgXSxdH;4bYNqfHliYYPzZZk> NWXJSpBFUUN3MDC9JFAvODFizszN NVrGPHRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
HT29 MnPwR5l1d3SxeHnjbZR6KGG|c3H5 MnjZTWM2OCB;IECuNFUh|ryP MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
H295R MonzR5l1d3SxeHnjbZR6KGG|c3H5 NXXLTnI4UUN3MDC9JFAvODhizszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
BNL MYjDfZRwfG:6aXPpeJkh[XO|YYm= MoG2TWM2OCB;IECuNkDPxE1? NUTHU4lbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
4T1 M1fKTGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXPMeHJkUUN3MDC9JFAvOiEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
HepG2 M13mWmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3vxPWlEPTBiPTCwMlMh|ryP NXzPNVQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1N|k{PzdpPkG2OVM6Ozd5PD;hQi=>
U937 GTB NInVZYhEgXSxdH;4bYNqfHliYYPzZZk> NU\vZ3p6PzJiaB?= M1zXXGlEPTBiPTCwMlAxPTlizszN NX3WV2s4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[1OlI5PDBpPkG2OVYzQDRyPD;hQi=>
RPMI 8226/s MY\DfZRwfG:6aXPpeJkh[XO|YYm= NXzROmE2PzJiaB?= M3HNRWlEPTBiPTCwMlAxPyEQvF2= M{OwcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFQxLz5zNkW2Nlg1ODxxYU6=
CEM/s MUDDfZRwfG:6aXPpeJkh[XO|YYm= MVS3NkBp NXrneINDUUN3MDC9JFAvODB5IN88US=> MnvoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3NkK4OFAoRjF4NU[yPFQxRC:jPh?=
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WI38 NY\lSoxQS3m2b4TvfIlkcXS7IHHzd4F6 NV3SOZR4UUN3MDC9JFAvODR4ODFOwG0> MoLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5MkS4OFIoRjF4N{K0PFQzRC:jPh?=
HepG2 NX3pPXZvS3m2b4TvfIlkcXS7IHHzd4F6 M3\FPWlEPTBiPTC5MlQ6KM7:TR?= NGjjS5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyOFg1Oid-MU[3NlQ5PDJ:L3G+
HT29 M{nNe2N6fG:2b4jpZ4l1gSCjc4PhfS=> NEL6cGZGSzVyIE2gNE4xODZizszN M{LrcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OEewOFI5Lz5zNki3NFQzQDxxYU6=
K562 MmmwR5l1d3SxeHnjbZR6KGG|c3H5 NXvJPJg1TUN3MDC9JFAvODF2IN88US=> NI\LPVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNki3NFQzQCd-MU[4O|A1Ojh:L3G+
MCF7 NGiyTYJEgXSxdH;4bYNqfHliYYPzZZk> NIPUVFdGSzVyIE2gNE4xOzZizszN M4DnUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OEewOFI5Lz5zNki3NFQzQDxxYU6=
VA-13 NYjMTmlsS3m2b4TvfIlkcXS7IHHzd4F6 MXLJR|UxKD1iMD6wNFUh|ryP MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl|M{i2PEc,OTZ7M{O4Olg9N2F-
WI38 MnLHR5l1d3SxeHnjbZR6KGG|c3H5 Moj2TWM2OCB;IECuNFQh|ryP NUXVOY9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5N|M5PjhpPkG2PVM{QDZ6PD;hQi=>
VA13 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NUPh[pdPUUN3MDC9JFAvODB3IN88US=> MmL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
WI38 MkHSR5l1d3SxeHnjbZR6KGG|c3H5 NUDnNVBOUUN3MDC9JFAvODRizszN NGfmNnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C2O|E2PSd-MUewOlcyPTV:L3G+
Hep G2 M{nh[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M3X2dWlEPTBiPTC4MlEh|ryP MmTuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyNkexOVUoRjF5ME[3NVU2RC:jPh?=
TW01 NGG1bohEgXSxdH;4bYNqfHliYYPzZZk> MWXJR|UxKD1iMD6wNFA{KM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzFzM{K4PEc,OTdzMUOyPFg9N2F-
MCF7 MUfDfZRwfG:6aXPpeJkh[XO|YYm= MofPTWM2OCB;IECuNFAxPSEQvF2= M2n0c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MKN45 NXq4[5p1S3m2b4TvfIlkcXS7IHHzd4F6 Mlm3TWM2OCB;IECuNFAxPSEQvF2= M3\4W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MES-SA NGnrT4NEgXSxdH;4bYNqfHliYYPzZZk> NYLKc2xyUUN3MDC9JFAvODByNTFOwG0> MnW4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
HCT116 NXHWVYxzS3m2b4TvfIlkcXS7IHHzd4F6 MniwTWM2OCB;IECuNFAxPiEQvF2= NX2zUYRNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
RPTEC MX3DfZRwfG:6aXPpeJkh[XO|YYm= Ml7yTWM2OCB;IECuNFAxQSEQvF2= NFzMbos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
Hep3B NGjZT|dEgXSxdH;4bYNqfHliYYPzZZk> NFjPZ|NKSzVyIE2gNE4xODV2IN88US=> M1;PXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
NCI-H226 MlnJR5l1d3SxeHnjbZR6KGG|c3H5 MmTuTWM2OCB;IECuNFA3QCEQvF2= NEXGNnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
A498 NVT5NI9GS3m2b4TvfIlkcXS7IHHzd4F6 NYno[5lWUUN3MDC9JFAvODZzIN88US=> NF3pOIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
MDA435/LCC6 M{LWU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mlq0TWM2OCB;IECuNFAzQSEQvF2= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
multidrug resistant MDA435/LCC6 NIC4WXlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mm\rTWM2OCB;IECuNFA1QCEQvF2= M1y1R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW0OVA2Lz5zN{G1OFUxPTxxYU6=
P388 MkW5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2DhTGlEPTBiPTCwMlAzOiEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
adriamycin resistant P388 MmDxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4\HRWlEPTBiPTCwMlA{KM7:TR?= M4j4Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW0OVA2Lz5zN{G1OFUxPTxxYU6=
LT12 M3\EWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M1L5N|Q5KGh? Ml7NTWM2OCB;IECuNFA3KM7:TR?= NUfD[XhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
SKOV3 NVHBT5Q5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NFrtNm81QCCq MlHNTWM2OCB;IECuNFEh|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG2OEc,OTdzOEGxOlQ9N2F-
NCI-H460 MmXJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGi5OFU1QCCq M1PzU2lEPTBiPTCwMlAyKM7:TR?= NVXHOHI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
SF268 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M2C4S|Q5KGh? NFL4bZdKSzVyIE2gNE4xOSEQvF2= NV[2T2dTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
RKO NH\F[ldCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2rVR|Q5KGh? M1\aO2lEPTBiPTCwMlAyKM7:TR?= M4XEPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
KB/HeLa NIPHcJpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MUW0PEBp NV32fpQxUUN3MDC9JFAvODFizszN M1HENFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
P388 NUnFWo1pSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVrGWo1OPDhiaB?= NHS4R|NKSzVyIE2gNE4xPCEQvF2= NEfXem09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
L1210 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVS0PEBp M2TIcWlEPTBiPTCwMlA3KM7:TR?= M2\mNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
LT12 MDR MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYG0PEBp M2XydWlEPTBiPTCwMlQh|ryP NFfoS4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
A2780 MmTuR5l1d3SxeHnjbZR6KGG|c3H5 Mn2xTWM2OCB;IECuNFAyKM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
A2780-1A9 MmjRR5l1d3SxeHnjbZR6KGG|c3H5 MkPlTWM2OCB;IECuNFAyOSEQvF2= Ml[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{ME[xN|koRjF5MkC2NVM6RC:jPh?=
A549 NVjlcZZuS3m2b4TvfIlkcXS7IHHzd4F6 MVHJR|UxKD1iMD6wNFM3KM7:TR?= M3rybFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
1A9PTX22 NVX1WW9uS3m2b4TvfIlkcXS7IHHzd4F6 MVzJR|UxKD1iMD6wNVkh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
1A9PTX10 MnHCR5l1d3SxeHnjbZR6KGG|c3H5 NYHFRpN6UUN3MDC9JFAvODNizszN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
A2780AD MYnDfZRwfG:6aXPpeJkh[XO|YYm= M2nlcGlEPTBiPTCwMlkh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
KB NYj0bFNZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{X4SGlEPTBiPTCwMlAxOjR3IN88US=> NEnDZVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KyPFg4Oyd-MUeyNlg5PzN:L3G+
COLO205 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MlH2TWM2OCB;IECuNFA{OyEQvF2= NYfNe5NGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNlg5PzNpPkG3NlI5QDd|PD;hQi=>
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A2780 Mmq5R5l1d3SxeHnjbZR6KGG|c3H5 NIq3NolKSzVyIE2gNE4xODB5IN88US=> Mli5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVcoRjF5MkO5OVk4RC:jPh?=
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1A9 MVHDfZRwfG:6aXPpeJkh[XO|YYm= Ml3ySWQ2OCB;IECuNFAyKM7:TR?= Mn\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
MCF7 NHq0SmtEgXSxdH;4bYNqfHliYYPzZZk> NU[5dGJ6TUR3MDC9JFAvODBzMTFOwG0> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
DU145 NWnJd5dJS3m2b4TvfIlkcXS7IHHzd4F6 MWPFSFUxKD1iMD6wNFE{KM7:TR?= M4ewb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
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A549 NWjhdWZOS3m2b4TvfIlkcXS7IHHzd4F6 MWrFSFUxKD1iMD6wNFI{KM7:TR?= Ml\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
LNCAP NGn3fnZEgXSxdH;4bYNqfHliYYPzZZk> M1\FVGVFPTBiPTCwMlAxOjZizszN NYHHZoc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOVA5OzRpPkG3N|UxQDN2PD;hQi=>
PC3 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NILqfGhGTDVyIE2gNE4xPTV3IN88US=> NED2U3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
KBVIN MUPDfZRwfG:6aXPpeJkh[XO|YYm= NFi5WIRGTDVyIE2gNE4{OTFizszN MkHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NUC4N|QoRjF5M{WwPFM1RC:jPh?=
A2780 MmDlR5l1d3SxeHnjbZR6KGG|c3H5 NYT0S5I2UUN3MDC9JFAvODBzNjFOwG0> M1nlVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{m1OFY2Lz5zN{O5OVQ3PTxxYU6=
A2780/AD MXXDfZRwfG:6aXPpeJkh[XO|YYm= NHrrUYxKSzVyIE2gNE46OiEQvF2= Mof2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|OUW0OlUoRjF5M{m1OFY2RC:jPh?=
KB NWPCNY4{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MUXJR|UxKD1iMD6wNFI1PSEQvF2= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
COLO205 Mki0R5l1d3SxeHnjbZR6KGG|c3H5 M3myWWlEPTBiPTCwMlAxOzNizszN NEDaXnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxOlUzPCd-MUe0NVY2OjR:L3G+
KB8.5 M3PhOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M1v1dWlEPTBiPTCwMlAzPiEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KBV1 M1ewXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4LEeWlEPTBiPTCyMlAyOyEQvF2= NWPSTnZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVY2OjRpPkG3OFE3PTJ2PD;hQi=>
neural precursor MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWLFR|UxKD1iMD6wNUDPxE1? NEnO[3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxO|Y{OSd-MUe0NVc3OzF:L3G+
OVCAR-3 Mn;UR5l1d3SxeHnjbZR6KGG|c3H5 M1eyc2lEPTBiPTCwMlAxODJizszN NXu4eYV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
MDA-MB-231 MXjDfZRwfG:6aXPpeJkh[XO|YYm= M2HiNWlEPTBiPTCwMlAxPDVizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
MCF7 MXPDfZRwfG:6aXPpeJkh[XO|YYm= MWnJR|UxKD1iMD6wNFQ6KM7:TR?= MkLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
NCI-H1299 M3S4d2N6fG:2b4jpZ4l1gSCjc4PhfS=> NWrN[5JiQTZiaB?= M3rRSGlEPTBiPTCwMlAyPSEQvF2= MnLvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
A2780 M{nib2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mmm5TWM2OCB;IECuNFI2KM7:TR?= NVuyd5RQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
PC3 NHzVRnFEgXSxdH;4bYNqfHliYYPzZZk> MY\JR|UxKD1iMD6wO|ch|ryP MmfVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
LoVo M{TLSWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1nEfmlEPTBiPTCwMlA6KM7:TR?= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
L2987 NWPtXINtS3m2b4TvfIlkcXS7IHHzd4F6 M3:0UWlEPTBiPTCwMlIh|ryP M4TRN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
cells MUXDfZRwfG:6aXPpeJkh[XO|YYm= MVTJR|UxKD1iMD6wNFU6KM7:TR?= NITETJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0NlU4Pyd-MUe0OFI2Pzd:L3G+
cells M3fRcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXnVWpBMUUN3MDC9JFAvODFizszN MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6NUKwO{c,OTd2OEWyNFc9N2F-
A2780 NGTt[mhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrHWlBzUUN3MDC9JFAvODB{ODFOwG0> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
VA13 MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEfHUpBKSzVyIE2gNE4xODVizszN MnXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUC4O|goRjF5NEmwPFc5RC:jPh?=
WI38 NEP3ToVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWfJR|UxKD1iMD6wOEDPxE1? NEHoc2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5NFg4QCd-MUe0PVA5Pzh:L3G+
2780AD MmnQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;JR|UxKD1iMD6xPFMh|ryP M{DmVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEmwPFc5Lz5zN{S5NFg4QDxxYU6=
HepG2 MnrZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG[3bI9KSzVyIE2gPE4yKM7:TR?= NH2zWYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5NFg4QCd-MUe0PVA5Pzh:L3G+
HT29 MnfBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYm0PEBp MoHXS2k2OCB;IECuNFE2KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7OEm2NEc,OTd2OUi5OlA9N2F-
M21 M2jLO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlHPOFghcA>? NUXkS4FHT0l3MDC9JFAvODN5IN88US=> MofWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OUi5OlAoRjF5NEm4PVYxRC:jPh?=
MCF7 NX;IOZVuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUi0PEBp M2q0emdKPTBiPTCwMlA2PCEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7OEm2NEc,OTd2OUi5OlA9N2F-
1A9 MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkjSO|IhcA>? NXnMdmtKT0l3MDC9JFAvODByN{Gg{txO MnzNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEK1O|IoRjF5NUSyOVczRC:jPh?=
1A9/Ptx22 M{\0R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH7IcYM4OiCq NYH4Z2lrT0l3MDC9JFAvODVzIN88US=> MkTQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEK1O|IoRjF5NUSyOVczRC:jPh?=
1A9/Ptx10 MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX[2e2lVPzJiaB?= M3P4T2dKPTBiPTCwMlA3PCEQvF2= MnzvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NEK1O|IoRjF5NUSyOVczRC:jPh?=
cells expressing MRP1 MnfuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGLie41KSzVyIE2gNE4xODJ3IN88US=> M1jJUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NU[3NVIyLz5zN{W2O|EzOTxxYU6=
cells expressing Pgp/MRP1 Mn3oS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInrfWpKSzVyIE2gNk44KM7:TR?= NF\qU4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W2O|EzOSd-MUe1OlcyOjF:L3G+
VA13 MoLSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnEZVVKSzVyIE2gOUDPxE1? M3qzcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUm1NVM1Lz5zN{W5OVE{PDxxYU6=
MCF7 MVTGeY5kfGmxbjDhd5NigQ>? Ml7GTWM2OCB;IECuNFAyQCEQvF2= NHrpb4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wNVc{QSd-MUe2NFE4Ozl:L3G+
adriamycin-resistant MCF7 MYTGeY5kfGmxbjDhd5NigQ>? M1W4cWlEPTBiPTC4MlIh|ryP MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZyMUezPUc,OTd4MEG3N|k9N2F-
RPMI8226 M2P6O2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2GySWdKPTBiPTCwMlAxOiEQvF2= M{jiSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
HT29 NWXpTlNrS3m2b4TvfIlkcXS7IHHzd4F6 M37DbWdKPTBiPTCwMlAxOiEQvF2= NEXpSlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
COLO205 NIDOOWREgXSxdH;4bYNqfHliYYPzZZk> NITESHNIUTVyIE2gNE4xODNizszN M1rCZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
HCC2998 M3:2S2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXPHTVUxKD1iMD6wNFMh|ryP MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
HS578T MnrwR5l1d3SxeHnjbZR6KGG|c3H5 Mn71S2k2OCB;IECuNFA{KM7:TR?= NWTCS|NxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
PC3 NEXhPXlEgXSxdH;4bYNqfHliYYPzZZk> MkTtS2k2OCB;IECuNFA1KM7:TR?= M3nKclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
SNB75 NWqxUFBmS3m2b4TvfIlkcXS7IHHzd4F6 MmfsS2k2OCB;IECuNFA1KM7:TR?= M1vsR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
A549 MlL1R5l1d3SxeHnjbZR6KGG|c3H5 M2qyWGdKPTBiPTCwMlAxPCEQvF2= NFnHVnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
KM12 NXr4SVFwS3m2b4TvfIlkcXS7IHHzd4F6 MoPPS2k2OCB;IECuNFA1KM7:TR?= MojvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
DU145 M2X6SGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWDHTVUxKD1iMD6wNFUh|ryP MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
SK-OV3 NUP0[mVUS3m2b4TvfIlkcXS7IHHzd4F6 NYHUc4pKT0l3MDC9JFAvODB6IN88US=> Mn7MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
NCI-H322M MY\DfZRwfG:6aXPpeJkh[XO|YYm= NYDmb5l7T0l3MDC9JFAvODF|IN88US=> MnrPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
UACC257 M1Xie2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1PpTmdKPTBiPTCwMlA1KM7:TR?= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
HCT15 MVjDfZRwfG:6aXPpeJkh[XO|YYm= MXnHTVUxKD1iMD6xOVgh|ryP MmTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
ACHN MWDDfZRwfG:6aXPpeJkh[XO|YYm= NYDhe5BZT0l3MDC9JFAvOzl6IN88US=> NF;1dXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
HeLa NFnNWY5EgXSxdH;4bYNqfHliYYPzZZk> NH;idpZKSzVyIE2gNE4xODV4IN88US=> MmTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5NkSxOFgoRjF5N{[0NVQ5RC:jPh?=
MCF7 M4jxXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjCVG9CUUN3MDC9JFAvODF{NDFOwG0> M1vScVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
A549 M1LuSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NE\D[YlKSzVyIE2gNE4xOTJ4IN88US=> M{DvO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
HGC27 NHPkZnNEgXSxdH;4bYNqfHliYYPzZZk> MYnJR|UxKD1iMD63O|c5KM7:TR?= M4TrVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5N{[0NVQ5Lz5zN{e2OFE1QDxxYU6=
HL60 MlHKR5l1d3SxeHnjbZR6KGG|c3H5 NH7Kc3E4OiCq MlqyTWM2OCB;IECuPVMh|ryP MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh7NkixOkc,OTd6OU[4NVY9N2F-
P388 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NV3zc3BYPzJiaB?= NGK2fJBKSzVyIE2gNE46OyEQvF2= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh7NkixOkc,OTd6OU[4NVY9N2F-
BEL-7402 NEnobopEgXSxdH;4bYNqfHliYYPzZZk> NEjWdYEzPCCq M4P2UWlEPTBiPTCwMlk{KM7:TR?= NX3CPHBIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe4PVY5OTZpPkG3PFk3QDF4PD;hQi=>
A459 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NFTM[oIzPCCq M3;RcGlEPTBiPTCwMlk{KM7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh7NkixOkc,OTd6OU[4NVY9N2F-
HeLa NIPMNYhEgXSxdH;4bYNqfHliYYPzZZk> M4\NOGlEPTBiPTCwMlAzKM7:TR?= NVfuXnJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVExOTdpPkG3PVEyODF5PD;hQi=>
HepG2 M3PBeWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2DISmlEPTBiPTCwMlgzKM7:TR?= M4[0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUGxNFE4Lz5zN{mxNVAyPzxxYU6=
BGC823 MWHDfZRwfG:6aXPpeJkh[XO|YYm= MYjJR|UxKD1iMT6xOUDPxE1? NF3WTY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxNVAyPyd-MUe5NVExOTd:L3G+
Aro NULFNYh3S3m2b4TvfIlkcXS7IHHzd4F6 MXK3NkBp M4\veGlEPTBiPTCwMlAxODJizszN M{TveFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
PT45 MWTDfZRwfG:6aXPpeJkh[XO|YYm= NX\ZPVFuPzJiaB?= NE\6eVZKSzVyIE2gNE4xODVizszN NVy5fWFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
A549 MVzDfZRwfG:6aXPpeJkh[XO|YYm= MVi3NkBp MmHZTWM2OCB;IECuNFA3KM7:TR?= NHHoUYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
MCF7 M3q4R2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGHCcpg4OiCq MlOxTWM2OCB;IECuNFA4KM7:TR?= NUPHdJdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
HeLa NFzLUVNEgXSxdH;4bYNqfHliYYPzZZk> NIPWV4c4OiCq M3rvVmlEPTBiPTCwMlAxQCEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
Ovcar3 NFriRmJEgXSxdH;4bYNqfHliYYPzZZk> M{j2NFczKGh? NYXlWmtGUUN3MDC9JFAvODFizszN NXzBXoJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
HT29 MnjTR5l1d3SxeHnjbZR6KGG|c3H5 NFr6NWo4OiCq NWHwZ2FpUUN3MDC9JFAvODVizszN M{\kN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
A549T12 MYjDfZRwfG:6aXPpeJkh[XO|YYm= M13rNlczKGh? MUfJR|UxKD1iMD6wOkDPxE1? MoO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
H295R NHv0SGhEgXSxdH;4bYNqfHliYYPzZZk> NYO2SFE5PzJiaB?= M1zYdGlEPTBiPTCwMlA5KM7:TR?= NGDpRYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
A549T24 MoHOR5l1d3SxeHnjbZR6KGG|c3H5 NYX1NVlSPzJiaB?= NFjUTllKSzVyIE2gNE4yODJizszN NX32WYhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
OE33 NGHqeFVEgXSxdH;4bYNqfHliYYPzZZk> NI[3W|k4OiCq NFjQPYVKSzVyIE2gNE4zKM7:TR?= NFf5bIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
HepG2 NIP3Wm9EgXSxdH;4bYNqfHliYYPzZZk> NHTQNHE4OiCq M{X6[GlEPTBiPTCwMlMh|ryP NYD6Z49wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
OE19 M{nDbWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3rDeVczKGh? NV7zTW5GUUN3MDC9JFAvPCEQvF2= NFL2fZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
L12 M3PKPGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M4e3PVQ5KGh? MWDJR|UxKD1iMD6wNFYh|ryP MnHQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
NCI-H460 NInQ[JpEgXSxdH;4bYNqfHliYYPzZZk> NVnjfnROPDhiaB?= M4jRS2lEPTBiPTCwMlAyKM7:TR?= M{DX[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
SKOV3 Mle0R5l1d3SxeHnjbZR6KGG|c3H5 MonJOFghcA>? M3W1bGlEPTBiPTCwMlAyKM7:TR?= NWH2b29bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5O|M{PjFpPkG3PVc{OzZzPD;hQi=>
SF268 M{TCTmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2KzWlQ5KGh? MVnJR|UxKD1iMD6wNUDPxE1? M{fJU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
RKO MonCR5l1d3SxeHnjbZR6KGG|c3H5 NYnOTmo5PDhiaB?= NXyzSY1QUUN3MDC9JFAvODFizszN NHrnPGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
KB/HeLa NXzCUFhGS3m2b4TvfIlkcXS7IHHzd4F6 NFGwRnM1QCCq NWfVcIpPUUN3MDC9JFAvODFizszN MkjTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
P388 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NV;CWI81PDhiaB?= NUCySW5RUUN3MDC9JFAvODRizszN NIXpZms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis M{XIOWNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 M1zvZmVEPTBiPTCwMlA1QSEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
L1210 MoHLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MWq0PEBp MYjJR|UxKD1iMD6wOkDPxE1? M2POPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
cells after 48 hrs by XTT assay M1z5fWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2PwPWlEPTBiPTCwMlQh|ryP NFjqdIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
A2780 NXraOnA5S3m2b4TvfIlkcXS7IHHzd4F6 Mlv6TWM2OCB;IECuNFA3OyEQvF2= M4OyWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MECxNFg4Lz5zOECwNVA5PzxxYU6=
BGC823 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NIPyXJFKSzVyIE2gNE4xODdizszN Mn;YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMEGwPFcoRjF6MECxNFg4RC:jPh?=
A549 M1uwRmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUK4eXFjUUN3MDC9JFAvODF7IN88US=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDByMUC4O{c,OThyMEGwPFc9N2F-
HCT8 MmDmR5l1d3SxeHnjbZR6KGG|c3H5 NVzXbZFMUUN3MDC9JFAvODN5IN88US=> Mnr1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyMEGwPFcoRjF6MECxNFg4RC:jPh?=
Bel7402 NH;vZ3lEgXSxdH;4bYNqfHliYYPzZZk> M2fSTGlEPTBiPTCwMlEh|ryP NHnjSno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOECwNVA5Pyd-MUiwNFExQDd:L3G+
cells by alamar blue assay MUfGeY5kfGmxbjDhd5NigQ>? NFTTPI5KSzVyIE2gNE4xPCEQvF2= NWL6V451RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwO|A6PjVpPkG4NFcxQTZ3PD;hQi=>
PANC1 NUfwb4dtS3m2b4TvfIlkcXS7IHHzd4F6 NIHxeGk4OiCq MkfuTWM2OCB;IECuNFA4KM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB6MUK1O{c,OThyOEGyOVc9N2F-
DLD1 M2PvRmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVq3NkBp NEnBfY9KSzVyIE2gNE4xOTFizszN M3jMXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEixNlU4Lz5zOEC4NVI2PzxxYU6=
AsPC1 M1;KN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHTIOWc4OiCq MoToTWM2OCB;IECuNFIh|ryP NW\OPINqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwPFEzPTdpPkG4NFgyOjV5PD;hQi=>
NCI/ADR MmHRR5l1d3SxeHnjbZR6KGG|c3H5 NFLhXGM4OiCq MoiwTWM2OCB;IEGg{txO Mmf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyOEGyOVcoRjF6MEixNlU4RC:jPh?=
SK-BR3 NHrHNnFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2P1U|k3KGh? MmLXS2k2OCB;IE[uNUDPxE1? MmizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThzNkSyNFUoRjF6MU[0NlA2RC:jPh?=
A2780 M1S2e2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MWG5OkBp M3npNmlEPTBiPTCwMlAzOzRizszN NIrrRZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEG3O|AyPCd-MUixO|cxOTR:L3G+
SNU398 M2KzSmFxd3C2b4Ppd{Bie3OjeR?= MX[yOEBp MWDFR|UxKD1iMD6wNVEh|ryP NH7UNHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEG5O|YyPCd-MUixPVc3OTR:L3G+
HCT116 NVvSNWpISXCxcITvd4l{KGG|c3H5 M3LKelI1KGh? M1;FWGVEPTBiPTCwMlAzPCEQvF2= MlzaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThzOUe2NVQoRjF6MUm3OlE1RC:jPh?=
T47D Ml6yRZBweHSxc3nzJIF{e2G7 MYiyOEBp NYqzNYtDTUN3MDC9JFAvODN4IN88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDF7N{[xOEc,OThzOUe2NVQ9N2F-
SJSA1 NYq3TZlnS3m2b4TvfIlkcXS7IHHzd4F6 MXq2JIg> MVTJR|UxKD1iMD6wNFMzKM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ2M{[5Okc,OTh{NEO2PVY9N2F-
P388 M2r5ZmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYjKb2IxPzJiaB?= MYrJR|UxKD1iMD65N{DPxE1? NInrfoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK4NVk2Oid-MUiyPFE6PTJ:L3G+
HL60 M3T4N2N6fG:2b4jpZ4l1gSCjc4PhfS=> M361bFczKGh? MlLDTWM2OCB;IECuPVMh|ryP MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ6MUm1Nkc,OTh{OEG5OVI9N2F-
Bel7402 M4jDc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NV3iTHh4OjRiaB?= MV\JR|UxKD1iMD65N{DPxE1? M3;pd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkixPVUzLz5zOEK4NVk2OjxxYU6=
A549 MkPOR5l1d3SxeHnjbZR6KGG|c3H5 MVmyOEBp NX[2eW1FUUN3MDC9JFAvQTNizszN NGqwNpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK4NVk2Oid-MUiyPFE6PTJ:L3G+
KB M3fLcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkDjOFghcA>? NU\iTottUUN3MDC9JFAvODB2MjFOwG0> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ7NUS5NEc,OTh{OUW0PVA9N2F-
KBV20C M{XDWWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmrXOFghcA>? MUjJR|UxKD1iMT60OEDPxE1? NHL5fmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK5OVQ6OCd-MUiyPVU1QTB:L3G+
DU145 MYPDfZRwfG:6aXPpeJkh[XO|YYm= MnPIO|IhcA>? NUnKV|NpUUN3MDC9JFAvODB3IN88US=> NHj0[5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwPFU3Pid-MUizNFg2PjZ:L3G+
HL60 M3LCfGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1Lzb|czKGh? NX72WGFHUUN3MDC9JFAvODB3IN88US=> M1;D[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{C4OVY3Lz5zOEOwPFU3PjxxYU6=
MDA435 MWnDfZRwfG:6aXPpeJkh[XO|YYm= M3\nfFczKGh? NWiwO3Y4UUN3MDC9JFAvODB3IN88US=> NYjYblJXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjZpPkG4N|A5PTZ4PD;hQi=>
MESSA M3PofmN6fG:2b4jpZ4l1gSCjc4PhfS=> MV:3NkBp NITLUXRKSzVyIE2gNE4xODVizszN NEHwd|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwPFU3Pid-MUizNFg2PjZ:L3G+
P388 NH24UnREgXSxdH;4bYNqfHliYYPzZZk> MlrYO|IhcA>? MonaTWM2OCB;IECuNFEh|ryP NX[xbI1bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjZpPkG4N|A5PTZ4PD;hQi=>
HL60/TX1000 NIrmbIFEgXSxdH;4bYNqfHliYYPzZZk> NX3zOFRjPzJiaB?= NU\H[HRNUUN3MDC9JFUh|ryP MoXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MEi1OlYoRjF6M{C4OVY3RC:jPh?=
MESSA/DX5 MmfxR5l1d3SxeHnjbZR6KGG|c3H5 NYPvT3ZnPzJiaB?= Mm\wTWM2OCB;IEWg{txO NUXRPZNIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjZpPkG4N|A5PTZ4PD;hQi=>
K562 M1jKbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUW3NkBp M1XNOGlEPTBiPTCwMlAxODZizszN M1\QUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{GzN|A4Lz5zOEOxN|MxPzxxYU6=
KB3-1 M4\qT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rIZ|czKGh? M4[3NGlEPTBiPTCwMlAxOiEQvF2= NUHCd|d1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
HepG2 Mm\QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVq3NkBp MVfJR|UxKD1iMD6wNFch|ryP NWO3ZXhkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
KB V1 NX34Z4xtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX:3NkBp NXjC[JlPUUN3MDC9JFgh|ryP M2PVVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{GzN|A4Lz5zOEOxN|MxPzxxYU6=
A549 NX;RXpA4S3m2b4TvfIlkcXS7IHHzd4F6 MYSzJIRigXN? MonYTWM2OCB;IECuNFA4KM7:TR?= M2PhVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEG5NVU1Lz5zOESxPVE2PDxxYU6=
MCF7 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NIHJbpI{KGSjeYO= MWTJR|UxKD1iMD6wNVE4KM7:TR?= NWXsW5ViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NVkyPTRpPkG4OFE6OTV2PD;hQi=>
HepG2 MX\DfZRwfG:6aXPpeJkh[XO|YYm= NF;pO3Q{KGSjeYO= MVPJR|UxKD1iMD6wOFY5KM7:TR?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
MDA-MB-231 MmnGR5l1d3SxeHnjbZR6KGG|c3H5 MXWzJIRigXN? MkXyTWM2OCB;IECuNFcxOyEQvF2= NVHtWFR2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NVkyPTRpPkG4OFE6OTV2PD;hQi=>
Hep3B M1zMXmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXHMU3VqOyCmYYnz M1PoTWlEPTBiPTCwMlE{KM7:TR?= NEDHcXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESxPVE2PCd-MUi0NVkyPTR:L3G+
CCRF-CEM M17iZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYO3NkBp NFfkO4NKSzVyIE2gNE4xODF{N{Sg{txO M{i1OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NEWwOFU3Lz5zOES1NFQ2PjxxYU6=
HCT116 NUTNWWN1S3m2b4TvfIlkcXS7IHHzd4F6 MV63NkBp MlnRTWM2OCB;IECuNFAyOyEQvF2= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR3MES1Okc,OTh2NUC0OVY9N2F-
MX1 NVvXfFNIS3m2b4TvfIlkcXS7IHHzd4F6 M1;WTFczKGh? NFvqOWRKSzVyIE2gNE4xOzVizszN MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR3MES1Okc,OTh2NUC0OVY9N2F-
HeLa MnTGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NHzCR5A1QCCq NHHwbIVKSzVyIE2gNE4xODF3IN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4MUm5O{c,OTh2NkG5PVc9N2F-
HT29 MljaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUS0PEBp MlPsTWM2OCB;IECuNFAyQSEQvF2= NULkRowzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OlE6QTdpPkG4OFYyQTl5PD;hQi=>
U2OS M4WwWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXjmdoVJPDhiaB?= NWjaZZpuUUN3MDC9JFAvODJ2IN88US=> NIq1Ooo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES2NVk6Pyd-MUi0OlE6QTd:L3G+
A2780 MXvDfZRwfG:6aXPpeJkh[XO|YYm= MoTTO|IhcA>? Ml\UTWM2OCB;IECuNFAyOzhizszN MlvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NkW4OFYoRjF6NE[1PFQ3RC:jPh?=
MCF7 NInidGdEgXSxdH;4bYNqfHliYYPzZZk> MX23NkBp NHPwc49KSzVyIE2gNE4xODF5IN88US=> M2TqbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NE[1PFQ3Lz5zOES2OVg1PjxxYU6=
LCC6 NUnJU3lFS3m2b4TvfIlkcXS7IHHzd4F6 Mn\BO|IhcA>? NI\ITFZKSzVyIE2gNE4xODNzIN88US=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4NUi0Okc,OTh2NkW4OFY9N2F-
1A9PTX22 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M4POfFczKGh? MkXuTWM2OCB;IECuNVYxPyEQvF2= NIrpTHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES2OVg1Pid-MUi0OlU5PDZ:L3G+
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1A9PTX10 MV3DfZRwfG:6aXPpeJkh[XO|YYm= MXS3NkBp M4e4ZWlEPTBiPTCwMlU{Ojl3IN88US=> Mn7aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NkW4OFYoRjF6NE[1PFQ3RC:jPh?=
HT29 NHvmTnhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MUDHTVUxKD1iMD6wNVUh|ryP NUDGfmhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1NFI3OzlpPkG4OVAzPjN7PD;hQi=>
M21 MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXi1TZR1T0l3MDC9JFAvODN5IN88US=> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDVyMk[zPUc,OTh3MEK2N|k9N2F-
MCF7 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWLHTVUxKD1iMD6wOVQh|ryP M3\qTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUCyOlM6Lz5zOEWwNlY{QTxxYU6=
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HepG2/Dox M3zD[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXrqNoZwPzJiaB?= NVPmR3JrUUN3MDC9JFEvPCEQvF2= MoXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3MUK5PFQoRjF6NUGyPVg1RC:jPh?=
HT29 NITzdYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfpdJE5PDhiaB?= NGjPVGpIUTVyIE2gNE4xOTVizszN Mn31QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3N{mzPFcoRjF6NUe5N|g4RC:jPh?=
M21 NYrzfZF6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIP5OJo1QCCq M3Lz[2dKPTBiPTCwMlA{PyEQvF2= NWLGVnA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1O|k{QDdpPkG4OVc6Ozh5PD;hQi=>
MCF7 MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4S2TFQ5KGh? NUTqeZIxT0l3MDC9JFAvODV2IN88US=> NF31[4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW3PVM5Pyd-MUi1O|k{QDd:L3G+
KB403 MVvDfZRwfG:6aXPpeJkh[XO|YYm= MYeyOEBp M2Pic2lEPTBiPTCwMlAxOSEQvF2= M2WzdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUi2OFkyLz5zOEW4OlQ6OTxxYU6=
WRL68 M{\1UGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXSyOEBp NWG5dlV1UUN3MDC9JFAvODB2IN88US=> NHTTfHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW4OlQ6OSd-MUi1PFY1QTF:L3G+
MCF7 M4PITWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFW2WVczPCCq NXz6S3RnUUN3MDC9JFAvODB4IN88US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV6NkS5NUc,OTh3OE[0PVE9N2F-
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HEPG2 MonRR5l1d3SxeHnjbZR6KGG|c3H5 NYfJbHhSOjRiaB?= MmG5TWM2OCB;IECuNFA6KM7:TR?= M1LGNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUi2OFkyLz5zOEW4OlQ6OTxxYU6=
HCT116 NWPUV45SS3m2b4TvfIlkcXS7IHHzd4F6 NFS3PXdKSzVyIE2gNE4xOTN4IN88US=> NFnvc5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[wOlU1OCd-MUi2NFY2PDB:L3G+
SF268 M2D4cmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkXETWM2OCB;IECuNFE2OyEQvF2= NXXye4JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2NFY2PDBpPkG4OlA3PTRyPD;hQi=>
A549 NHXpOJFEgXSxdH;4bYNqfHliYYPzZZk> M2D2cWlEPTBiPTCwMlAzOzFizszN NVr4cW9jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2NFY2PDBpPkG4OlA3PTRyPD;hQi=>
MDA-MB-231 MoTaR5l1d3SxeHnjbZR6KGG|c3H5 M{XZNWlEPTBiPTCwMlA1ODVizszN NWfSbIhPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2NFY2PDBpPkG4OlA3PTRyPD;hQi=>
SF295 M2K1c2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mn;mTWM2OCB;IECuNlkh|ryP M4ryZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NkC2OVQxLz5zOE[wOlU1ODxxYU6=
MDA-MB-435 NXLrZlk1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXrWSW9RPzJiaB?= NHvQeJZIUTVyIE2gNE4xODRizszN NYTVOG5PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2NVA6QTVpPkG4OlExQTl3PD;hQi=>
HT29 M1;BbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYm2XGp{PDhiaB?= M4XpU2dKPTBiPTCwMlAyPSEQvF2= Mn7mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4MUe0NVQoRjF6NkG3OFE1RC:jPh?=
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MCF7 MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M2i0bVQ5KGh? NGDQc3JIUTVyIE2gNE4xPTRizszN NFrxeJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[xO|QyPCd-MUi2NVc1OTR:L3G+
SKOV3 NV3OOXJTS3m2b4TvfIlkcXS7IHHzd4F6 NHHZ[JBKSzVyIE2gNk41OyEQvF2= M4HycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{CxNlgyLz5zOEewNVI5OTxxYU6=
KB MVXDfZRwfG:6aXPpeJkh[XO|YYm= NE\CeW5KSzVyIE2gNk42PCEQvF2= NI\TU489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEewNVI5OSd-MUi3NFEzQDF:L3G+
Eca109 MXXDfZRwfG:6aXPpeJkh[XO|YYm= Mnm1TWM2OCB;IEKuO|Mh|ryP M3vKXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{CxNlgyLz5zOEewNVI5OTxxYU6=
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MCF7 M1vUU2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1nDSGlEPTBiPTCyMlk5KM7:TR?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDdyMUK4NUc,OTh5MEGyPFE9N2F-
HeLa MV3DfZRwfG:6aXPpeJkh[XO|YYm= Mo[4TWM2OCB;IEOuNVEh|ryP MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDdyMUK4NUc,OTh5MEGyPFE9N2F-
HCT8 NFHPTldEgXSxdH;4bYNqfHliYYPzZZk> NHnNXHNKSzVyIE2gN{4zQSEQvF2= M4S5XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{CxNlgyLz5zOEewNVI5OTxxYU6=
K562 M{PzcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVHpTHR4UUN3MDC9JFMvPjVizszN NX\mXHlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3NFEzQDFpPkG4O|AyOjhzPD;hQi=>
HepG2 M1HJOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWXEO41GPDhiaB?= NFXjfopKSzVyIE2gNE43OiEQvF2= NHXv[5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEewNVMxOSd-MUi3NFE{ODF:L3G+
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HCT116 M2W0W2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NH;kXnI1QCCq NVzwXI9PUUN3MDC9JFYvOThizszN NFPUdGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEewNVMxOSd-MUi3NFE{ODF:L3G+
A549 NV;Kd4lxS3m2b4TvfIlkcXS7IHHzd4F6 M365TmlEPTBiPTCwMlAxOiEQvF2= M13Ze|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{G1O|gzLz5zOEexOVc5OjxxYU6=
CCRF-CEM M1\2TWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4HwR|czKGh? MmfTTWM2OCB;IECuNFAyOSEQvF2= NGr3fGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEe1Nlg3QSd-MUi3OVI5Pjl:L3G+
SKOV3 NHe5XnlCdnSrY3HuZ4VzKGG|c3H5 MlTwO|IhcA>? M1HjVGlEPTBiPTCwMlAxOTN2IN88US=> M3jRblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{[yN|U5Lz5zOEe2NlM2QDxxYU6=
MCF7 MULDfZRwfG:6aXPpeJkh[XO|YYm= NFyxUZBGTDVyIE2gNE4xODN{IN88US=> MkS1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7Mk[3NFEoRjF6OUK2O|AyRC:jPh?=
NCI/ADR-RES NYH0e4RtS3m2b4TvfIlkcXS7IHHzd4F6 NUnPdIRlTUR3MDC9JFEvPSEQvF2= NVf6No5[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5NlY4ODFpPkG4PVI3PzBzPD;hQi=>
PANC1 NYq4dlZ4S3m2b4TvfIlkcXS7IHHzd4F6 NUnEU2hOPzJiaB?= MWrJR|UxKD1iMD6wNFk6KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl3MUe4O{c,OTh7NUG3PFc9N2F-
DLD1 M3e5UmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlTiO|IhcA>? NVPDcnB7UUN3MDC9JFAvODJ{IN88US=> MkDtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7NUG3PFcoRjF6OUWxO|g4RC:jPh?=
AsPC1 MofYR5l1d3SxeHnjbZR6KGG|c3H5 MoDEO|IhcA>? MnHtTWM2OCB;IECuNFg6KM7:TR?= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl3MUe4O{c,OTh7NUG3PFc9N2F-
NCI/ADR-RES NXLDTmRRS3m2b4TvfIlkcXS7IHHzd4F6 NFnCZXY4OiCq MorjTWM2OCB;IEGuN{DPxE1? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl3MUe4O{c,OTh7NUG3PFc9N2F-
MCF7 MlOxR5l1d3SxeHnjbZR6KGG|c3H5 NIfHS4lGTDVyIE2gNE4xODJzIN88US=> M3nCOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUe3OlU6Lz5zOEm3O|Y2QTxxYU6=
NCI/ADR-RES M4HvVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVPFSFUxKD1iMjFOwG0> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl5N{[1PUc,OTh7N{e2OVk9N2F-
A431 M2j2WmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFLWe5E4OiCq M{LHZ2lEPTBiPTCwMlAzPTFizszN Mor3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7OUC1O|QoRjF6OUmwOVc1RC:jPh?=
MCF7 NXrn[GZLS3m2b4TvfIlkcXS7IHHzd4F6 MkO0O|IhcA>? MY\JR|UxKD1iMD6wN|kh|ryP MmPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7OUC1O|QoRjF6OUmwOVc1RC:jPh?=
MDA-MB-231 MUXDfZRwfG:6aXPpeJkh[XO|YYm= NXzJSoZuPzJiaB?= MoG4TWM2OCB;IECuNFQ4OSEQvF2= Moj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7OUC1O|QoRjF6OUmwOVc1RC:jPh?=
SKOV3 MUfDfZRwfG:6aXPpeJkh[XO|YYm= MoTiO|IhcA>? NIjvVIhKSzVyIE2gNE4xPjV6IN88US=> M3v3XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUmwOVc1Lz5zOEm5NFU4PDxxYU6=
PANC1 NYnDfY06T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUG1SIdVPzJiaB?= NHfaZpZKSzVyIE2gNE4xODl7IN88US=> NFf3fm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCyNlY4QSd-MUmwNlI3Pzl:L3G+
DLD1 Ml\TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWG3NkBp NX3U[oZLUUN3MDC9JFAvODJ{IN88US=> NWP5T497RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNlI3PzlpPkG5NFIzPjd7PD;hQi=>
AsPC1 MlPqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEC4OXE4OiCq NFXvbZdKSzVyIE2gNE4xQDlizszN NVKxd5JPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNlI3PzlpPkG5NFIzPjd7PD;hQi=>
NCI/ADR MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYHVW|R[PzJiaB?= NGTnW49KSzVyIE2gNU4{KM7:TR?= M1;HdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEKyOlc6Lz5zOUCyNlY4QTxxYU6=
A2780 M2juRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NF7Gd|gzKGSjeYO= Ml3HTWM2OCB;IECuNFI{PCEQvF2= M1H4[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEK4NVAzLz5zOUCyPFExOjxxYU6=
KB NGTDSpVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MoHUN{Bl[Xm| MkW3TWM2OCB;IECuNFAzPSEQvF2= NXHJVmtXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOFEzPDdpPkG5NFQyOjR5PD;hQi=>
COLO205 NInldYRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{PEfVI1KGh? MUHJR|UxKD1iMD6wNFM{KM7:TR?= NF\ybXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC0NVI1Pyd-MUmwOFEzPDd:L3G+
KB 8.5 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVezJIRigXN? MoHQTWM2OCB;IECuNFI3KM7:TR?= MnzxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNEGyOFcoRjF7MESxNlQ4RC:jPh?=
KBV1 Ml7TRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NES5Spo{KGSjeYO= NGrQNnRKSzVyIE2gNk4xOTNizszN MlXMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNEGyOFcoRjF7MESxNlQ4RC:jPh?=
KB MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M17RV|czKGh? M{\Sd2lEPTBiPTCwMlAxOzNizszN NEHjOHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c4Oyd-MUmwOVM4PzN:L3G+
KB-7D MmTkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3ruNlczKGh? MWrJR|UxKD1iMD6wNFc6KM7:TR?= NVG2WoV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOVM4PzNpPkG5NFU{Pzd|PD;hQi=>
Pgp170 overexpressing multidrug resistant-KB-TAX50 NUT4VIt6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnLSO|IhcA>? NEXaSmZKSzVyIE2gNE4zPzNizszN MmOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUO3O|MoRjF7MEWzO|c{RC:jPh?=
NPC-TW01 NHzLfGtEgXSxdH;4bYNqfHliYYPzZZk> NGfMNno4OiCq M{P4VmlEPTBiPTCwMlAxPiEQvF2= NGr3Vlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c5OSd-MUmwOVM4QDF:L3G+
MES-SA MnrBR5l1d3SxeHnjbZR6KGG|c3H5 NVuwSJllPzJiaB?= MX\JR|UxKD1iMD6wNFgh|ryP NEHZUFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c5OSd-MUmwOVM4QDF:L3G+
NCI-H838 M4S1UWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnrRO|IhcA>? M3fpb2lEPTBiPTCwMlAzPiEQvF2= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e4NUc,OTlyNUO3PFE9N2F-
HCT116 NV7CXY55S3m2b4TvfIlkcXS7IHHzd4F6 M1yw[lczKGh? M2nXRWlEPTBiPTCwMlA3OSEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e4NUc,OTlyNUO3PFE9N2F-
cells after 72 hrs by MTT assay NITZWmhEgXSxdH;4bYNqfHliYYPzZZk> M{XKeWlEPTBiPTC1MlE1KM7:TR?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e4NUc,OTlyNUO3PFE9N2F-
Hep3B NF\KbWlEgXSxdH;4bYNqfHliYYPzZZk> M3GxN|czKGh? M2XpPWlEPTBiPTC3MlI3KM7:TR?= NWfpR4EyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOVM4QDFpPkG5NFU{PzhzPD;hQi=>
A498 MnvUR5l1d3SxeHnjbZR6KGG|c3H5 Mm\xO|IhcA>? M1zlT2lEPTBiPTC4MlgyKM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e4NUc,OTlyNUO3PFE9N2F-
NB4 NGnsdYNEgXSxdH;4bYNqfHliYYPzZZk> MWS0PEBp M2TLZmlEPTBiPTCwMlEh|ryP Mor3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{KyNFkoRjF7MEeyNlA6RC:jPh?=
A549 MnvRR5l1d3SxeHnjbZR6KGG|c3H5 MlzmOFghcA>? MmP5TWM2OCB;IECuNUDPxE1? NF7wboU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlIxQSd-MUmwO|IzODl:L3G+
MCF7 MkXWR5l1d3SxeHnjbZR6KGG|c3H5 MYW0PEBp NHfBdodKSzVyIE2gNE4yKM7:TR?= NGHjeZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlIxQSd-MUmwO|IzODl:L3G+
SH-SY5Y M4[3NmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIf5NVI1QCCq NYTwNIRvUUN3MDC9JFAvOiEQvF2= NF6welE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlIxQSd-MUmwO|IzODl:L3G+
PC3 NVHzcWNmS3m2b4TvfIlkcXS7IHHzd4F6 M13FUlQ5KGh? Ml;OTWM2OCB;IECuNkDPxE1? M33BelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEeyNlA6Lz5zOUC3NlIxQTxxYU6=
DLD1 M3LLbGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUW2[4R6PzJiaB?= M3S4RmdKPTBiPTCwMlAyKM7:TR?= NYfMVJdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPFEzPDlpPkG5NFgyOjR7PD;hQi=>
B16 NG\5TJZEgXSxdH;4bYNqfHliYYPzZZk> NYTMNpk6PzJiaB?= MV;HTVUxKD1iMD6wNUDPxE1? M1z0VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEixNlQ6Lz5zOUC4NVI1QTxxYU6=
A172 NXHUOHN{S3m2b4TvfIlkcXS7IHHzd4F6 Ml\DO|IhcA>? Ml;hS2k2OCB;IECuNFEh|ryP M1y3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEixNlQ6Lz5zOUC4NVI1QTxxYU6=
HeLa NVvUVmF3S3m2b4TvfIlkcXS7IHHzd4F6 Ml;xO|IhcA>? MXjHTVUxKD1iMD6wNkDPxE1? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB6MUK0PUc,OTlyOEGyOFk9N2F-
U87 NGrsTnhEgXSxdH;4bYNqfHliYYPzZZk> M{LCelczKGh? MX;HTVUxKD1iMD6wNkDPxE1? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB6MUK0PUc,OTlyOEGyOFk9N2F-
SiHa NVX6b2FXS3m2b4TvfIlkcXS7IHHzd4F6 MU[3NkBp NUf5SnoyT0l3MDC9JFAvODNizszN MnPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyOEGyOFkoRjF7MEixNlQ6RC:jPh?=
HeLa NHvtXGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mn[yPVYhcA>? MnjQTWM2OCB;IECuNFAyKM7:TR?= M2HucVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEmxOVc6Lz5zOUC5NVU4QTxxYU6=
SKOV3 NEnoPGVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mm\kPVYhcA>? NUSydotJUUN3MDC9JFAvODF4IN88US=> NVLT[lFtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPVE2PzlpPkG5NFkyPTd7PD;hQi=>
BGC823 M{PzNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXTOd2hrQTZiaB?= MYfJR|UxKD1iMD6wNVg6KM7:TR?= NXSx[ZpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPVE2PzlpPkG5NFkyPTd7PD;hQi=>
HCT116 M2PM[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NH3HXnQ4OiCq MV3JR|UxKD1iMD6wNFEyKM7:TR?= NV;PUGxFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxNlQzPTBpPkG5NVI1OjVyPD;hQi=>
CCRF-CEM NVuw[GVDS3m2b4TvfIlkcXS7IHHzd4F6 MWS3NkBp M{j0WmlEPTBiPTCwMlAxOzFizszN M2TjOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK0NlUxLz5zOUGyOFI2ODxxYU6=
MX1 NWfsbWl{S3m2b4TvfIlkcXS7IHHzd4F6 Mo\oO|IhcA>? MWDJR|UxKD1iMD6wOFYh|ryP Mnn1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMkSyOVAoRjF7MUK0NlUxRC:jPh?=
HCT116 NWn6[WxCS3m2b4TvfIlkcXS7IHHzd4F6 NFz2cmc1KGSjeYO= MmXxTWM2OCB;IECuNFAyOSEQvF2= NFHoSYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyPFE2Pid-MUmxNlgyPTZ:L3G+
HT-29 MUPDfZRwfG:6aXPpeJkh[XO|YYm= NWj1bFg3PCCmYYnz NEGwbW5KSzVyIE2gNE4xODN4IN88US=> M33HRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK4NVU3Lz5zOUGyPFE2PjxxYU6=
A2780 NFLzS|VEgXSxdH;4bYNqfHliYYPzZZk> Mn\DOFghcA>? MWDJR|UxKD1iMD6wNFE{KM7:TR?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF{OEm3Nkc,OTlzMki5O|I9N2F-
KB MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmTRSWQ2OCB;IECuNFI{KM7:TR?= NH;RZoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG2NVMyPid-MUmxOlE{OTZ:L3G+
HepG2 M4\mRWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYDHTVUxKD1iMD6wNFEh|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF7NUmwNUc,OTlzOUW5NFE9N2F-
WI38 NFqwfplEgXSxdH;4bYNqfHliYYPzZZk> MnrzS2k2OCB;IECuNFE{PyEQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF7NUmwNUc,OTlzOUW5NFE9N2F-
RKO MmHHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGP2N5ZKSzVyIE2gNE4xOiEQvF2= NFThTmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNFAyQCd-MUmyNlAxOTh:L3G+
KB/HeLa NH20dFlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{[yT2lEPTBiPTCwMlA{KM7:TR?= NHnkfpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNFAyQCd-MUmyNlAxOTh:L3G+
SKOV3 MnTuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUDUdlZiUUN3MDC9JFAvODVizszN Mly3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkCwNVgoRjF7MkKwNFE5RC:jPh?=
SF268 NYOwcItLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{Ta[2lEPTBiPTCwMlA2KM7:TR?= NUHXOVFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
P388 NEThVXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHyyXJI1QCCq NUDaZmltUUN3MDC9JFAvODVizszN MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
cells ectopic expression of human NVH0NWdvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MoPxOFghcA>? MkLuTWM2OCB;IECuNFUh|ryP NYTGdW42RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
L1210 NFnoUFlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{nnVVQ5KGh? MYHJR|UxKD1iMD6wOkDPxE1? NEPLXJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKyNFAyQCd-MUmyNlAxOTh:L3G+
NCI-H460 NXfTXJdkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4G2S2lEPTBiPTCwMlA4KM7:TR?= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
MlzLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4\vOlQ5KGh? M3TTSGlEPTBiPTCwMlMh|ryP M{jqSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
MCF7 NGSwNGdEgXSxdH;4bYNqfHliYYPzZZk> NFi4Oo04OiCq MYrJR|UxKD1iMD6wNFEzKM7:TR?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
A2780 M4rJSGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHPIXJU4OiCq NH31fphKSzVyIE2gNE4xODF|ODFOwG0> M4Tqd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
wild type A2780 NFzETHBEgXSxdH;4bYNqfHliYYPzZZk> NVLlUmdZPzJiaB?= M{ixUWlEPTBiPTCwMlAxOTdizszN MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
cisplatin-resistant A2780 MXLDfZRwfG:6aXPpeJkh[XO|YYm= MnfWO|IhcA>? MVjJR|UxKD1iMD6wNFIzKM7:TR?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
LCC-6 NXTqNWV3S3m2b4TvfIlkcXS7IHHzd4F6 NHrLR484OiCq MWnJR|UxKD1iMD6wNFI1PSEQvF2= Mnm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
HT-29 MmfER5l1d3SxeHnjbZR6KGG|c3H5 M{HiWFczKGh? M4X2ZmlEPTBiPTCwMlAxOzZizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
H460 MmDiR5l1d3SxeHnjbZR6KGG|c3H5 M2S0TFczKGh? NF;icXdKSzVyIE2gNE4xODR7IN88US=> M4PzOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
topotecan-resistant A2780 NH7yT41EgXSxdH;4bYNqfHliYYPzZZk> NFrTV4E4OiCq NIjufGlKSzVyIE2gNE4xODd{IN88US=> NUjRUYtqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
PANC1 Mk\CR5l1d3SxeHnjbZR6KGG|c3H5 NFzxNYs4OiCq MWTJR|UxKD1iMD6wNlU4KM7:TR?= M3P1V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
1A9PTX22 NEjnUW1EgXSxdH;4bYNqfHliYYPzZZk> NVjESHA5PzJiaB?= Ml;MTWM2OCB;IECuNVYxPyEQvF2= NGPYbFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzPVI1OCd-MUmyN|kzPDB:L3G+
NCI/ADR NH;sO4ZEgXSxdH;4bYNqfHliYYPzZZk> MmG1O|IhcA>? M3qx[GlEPTBiPTCwMlMh|ryP Mn7EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
A2780 NXjuXmE5TnWwY4Tpc44h[XO|YYm= M3HoOGlEPTBiPTCwMlM5PiEQvF2= NED6OJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzPVI1OCd-MUmyN|kzPDB:L3G+
1A9PTX10 NGrlXllEgXSxdH;4bYNqfHliYYPzZZk> NWPvWWhTPzJiaB?= MlTkTWM2OCB;IECuOVMzQTVizszN NY\yRXRWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
A2780/ADR MWDDfZRwfG:6aXPpeJkh[XO|YYm= MofmO|IhcA>? NEHZTJhKSzVyIE2gNU4zOzlizszN NYC1SWV{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
A549 M{PlTWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1\xTlI1KGh? M3XDcWlEPTBiPTCwMlAxPTJizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ2NUK2NUc,OTl{NEWyOlE9N2F-
PC3M NWPJdGd[S3m2b4TvfIlkcXS7IHHzd4F6 NHrFTmwzPCCq NXzGO2ttUUN3MDC9JFAvODJ5IN88US=> NUDDSFB1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOFUzPjFpPkG5NlQ2OjZzPD;hQi=>
HCT8 NVfXU2t6S3m2b4TvfIlkcXS7IHHzd4F6 NFXze2ozPCCq MVnJR|UxKD1iMD6wN|ch|ryP NWHoc|Z5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOFUzPjFpPkG5NlQ2OjZzPD;hQi=>
Bel7402 NGDLdJVEgXSxdH;4bYNqfHliYYPzZZk> NU\UVFlOOjRiaB?= NVO3VZR3UUN3MDC9JFAvODl3IN88US=> M2jiRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkS1NlYyLz5zOUK0OVI3OTxxYU6=
A2780 MoDIR5l1d3SxeHnjbZR6KGG|c3H5 M1TyV2lEPTBiPTCwMlAyPCEQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ6MkG4Okc,OTl{OEKxPFY9N2F-
SNU398 NWHFPIxZSXCxcITvd4l{KGG|c3H5 NY\Nc3BLPDhiaB?= NH:1bVNIUTVyIE2gNE4xOSEQvF2= M2nkfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkiyNVg5Lz5zOUK4NlE5QDxxYU6=
HCT116 MlrKRZBweHSxc3nzJIF{e2G7 MmHOOFghcA>? NV;Q[FVVTUN3MDC9JFAvODJ|IN88US=> Ml3RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{OEKxPFgoRjF7MkiyNVg5RC:jPh?=
T47D NVj0WVJ{SXCxcITvd4l{KGG|c3H5 M{DMS|Q5KGh? NWjLc4xZTUN3MDC9JFAvODN3IN88US=> NVfy[mpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFIyQDhpPkG5NlgzOTh6PD;hQi=>
PC3 NIqyOZBEgXSxdH;4bYNqfHliYYPzZZk> M2LEdVQh\GG7cx?= NFv4Rm9KSzVyIE2gNE4xODF2IN88US=> NWjQN49RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzOVkyPjlpPkG5N|U6OTZ7PD;hQi=>
A2780 M2OxWmN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml3YOEBl[Xm| MWXJR|UxKD1iMD6wNVQ6KM7:TR?= M2LJTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{W5NVY6Lz5zOUO1PVE3QTxxYU6=
K562 MoTTR5l1d3SxeHnjbZR6KGG|c3H5 Mn3EOFghcA>? MWnJR|UxKD1iMT6xOkDPxE1? M1fNXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{W5NVg2Lz5zOUO1PVE5PTxxYU6=
MCF7 Mnu3R5l1d3SxeHnjbZR6KGG|c3H5 NX76[2JZPDhiaB?= MkC0TWM2OCB;IEKuNVEh|ryP Mk\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|NUmxPFUoRjF7M{W5NVg2RC:jPh?=
A549 MnqzR5l1d3SxeHnjbZR6KGG|c3H5 MXK0PEBp MmD3TWM2OCB;IEKuOFYh|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN3OUG4OUc,OTl|NUmxPFU9N2F-
SGC MVTDfZRwfG:6aXPpeJkh[XO|YYm= M2fjNlQ5KGh? M3HLPGlEPTBiPTCzMlM1KM7:TR?= NUK5Wo1[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzOVkyQDVpPkG5N|U6OTh3PD;hQi=>
HCT116 NEjFWnREgXSxdH;4bYNqfHliYYPzZZk> NHv5e5E1QCCq NIrKfXFKSzVyIE2gOE4{PyEQvF2= NUHleFdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzOVkyQDVpPkG5N|U6OTh3PD;hQi=>
A431 NWDySnlISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWjQW2FnT0l3MDC9JFAvODByMEGg{txO NGezUmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5OFIyQCd-MUmzPVQzOTh:L3G+
MESSA MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYLHTVUxKD1iMD6wNFAxOSEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7NEKxPEc,OTl|OUSyNVg9N2F-
HCT15 NH3aZWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXvHTVUxKD1iMD6wNVEh|ryP NXPkbXlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVQzOThpPkG5N|k1OjF6PD;hQi=>
MES-SA/Dx5 NFe4NlNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mn3MS2k2OCB;IECuNVYh|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7NEKxPEc,OTl|OUSyNVg9N2F-
HCT15/CLO2 NFHEdolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MX3HTVUxKD1iMD64N{DPxE1? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7NEKxPEc,OTl|OUSyNVg9N2F-
wild type A2780 MkS3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXq3NkBp MmDjTWM2OCB;IECuNFAyPyEQvF2= M3nFTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEKzN|QxLz5zOUSyN|M1ODxxYU6=
cisplatin-resistant A2780 M1XKfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{XxSFczKGh? MX\JR|UxKD1iMD6wNFIzKM7:TR?= NXHDSXRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlM{PDBpPkG5OFI{OzRyPD;hQi=>
topotecan-resistant A2780 NX3R[ZZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mm\YO|IhcA>? Mn2yTWM2OCB;IECuNFA4OiEQvF2= MnrtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkOzOFAoRjF7NEKzN|QxRC:jPh?=
adriamycin and doxorubicin-resistant A2780 NIKyPYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVLWeZNGPzJiaB?= M4\hXmlEPTBiPTCxMlI{QSEQvF2= NXfIPI1nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlM{PDBpPkG5OFI{OzRyPD;hQi=>
paclitaxel-resistant A2780TC1 NGLBZWpHfW6ldHnvckBie3OjeR?= MX7JR|UxKD1iNT64PVgh|ryP NWLxdHljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlM{PDBpPkG5OFI{OzRyPD;hQi=>
NB4 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NUfsO|ZvPDhiaB?= NUjpcYViUUN3MDC9JFAvOSEQvF2= NH7vU4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyOVU5QSd-MUm0NlU2QDl:L3G+
A549 NHm0fnREgXSxdH;4bYNqfHliYYPzZZk> MVi0PEBp MnTrTWM2OCB;IECuNUDPxE1? NW\sVIZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlU2QDlpPkG5OFI2PTh7PD;hQi=>
MCF7 NXnVeHBCS3m2b4TvfIlkcXS7IHHzd4F6 NF3zb2g1QCCq M2n6XmlEPTBiPTCwMlEh|ryP NV7jfYJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlU2QDlpPkG5OFI2PTh7PD;hQi=>
SH-SY5Y NFPqW2ZEgXSxdH;4bYNqfHliYYPzZZk> MVm0PEBp MX7JR|UxKD1iMD6yJO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR{NUW4PUc,OTl2MkW1PFk9N2F-
PC3 MVfDfZRwfG:6aXPpeJkh[XO|YYm= M{m4cVQ5KGh? NEjtbYRKSzVyIE2gNE4zKM7:TR?= M2DMcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEK1OVg6Lz5zOUSyOVU5QTxxYU6=
SNU398 NIXWb|JCeG:ydH;zbZMh[XO|YYm= Ml;3OFghcA>? NXPHS5RrTUN3MDC9JFAvODB7IN88US=> NUjCSHZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olc2QThpPkG5OFY4PTl6PD;hQi=>
HCT116 MU\BdI9xfG:|aYOgZZN{[Xl? M{ixeFQ5KGh? NEDteJZGSzVyIE2gNE4xOThizszN M1TKVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NE[3OVk5Lz5zOUS2O|U6QDxxYU6=
T47D NI\hb3NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\GeFQ5KGh? NUDJ[FdqT0l3MDC9JFAvODJ4IN88US=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4N{W5PEc,OTl2Nke1PVg9N2F-
MCF7 NXrzTm9LS3m2b4TvfIlkcXS7IHHzd4F6 NEHaZZI1QCCq M3;3RmlEPTBiPTCwMlA5KM7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4N{i3O{c,OTl2Nke4O|c9N2F-
HepG2 NU\GWo9WS3m2b4TvfIlkcXS7IHHzd4F6 NVvQV|J{T0l3MDC9JFAvODV7IN88US=> NGfaOnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS3OlM{Pid-MUm0O|Y{OzZ:L3G+
H1299 MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWC2TYZnPDhiaB?= MoThS2k2OCB;IECuNFI{KM7:TR?= NXvuZpQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1NFA6PzZpPkG5OVAxQTd4PD;hQi=>
T47D MonRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV:0PEBp M2TVR2dKPTBiPTCwMlAzPiEQvF2= NVjBUpJGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1NFA6PzZpPkG5OVAxQTd4PD;hQi=>
DLD1 NEPmd3NCeG:ydH;zbZMh[XO|YYm= NXnlPHQ4PDhiaB?= M13KbmVEPTBiPTCwMlA2PCEQvF2= M2\idlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NUCwPVc3Lz5zOUWwNFk4PjxxYU6=
HCT116 M4S4PWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVzPc3JYPzJiaB?= MVnJR|UxKD1iMD6wNFEyKM7:TR?= NHTvUoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW3Olc5PSd-MUm1O|Y4QDV:L3G+
CCRF-CEM NWrxN4NTS3m2b4TvfIlkcXS7IHHzd4F6 MlrVO|IhcA>? MnXPTWM2OCB;IECuNFAyOiEQvF2= NWexNoVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1O|Y4QDVpPkG5OVc3Pzh3PD;hQi=>
MX1 NV;CcW8yS3m2b4TvfIlkcXS7IHHzd4F6 M3fsXVczKGh? MofaTWM2OCB;IECuNFQ3KM7:TR?= NHq0TGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW3Olc5PSd-MUm1O|Y4QDV:L3G+
vinblastine-resistant CCRF-CEM NVe5emRGS3m2b4TvfIlkcXS7IHHzd4F6 MVG3NkBp NX7WdWs1UUN3MDC9JFAvPCEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV5Nke4OUc,OTl3N{[3PFU9N2F-
taxol-resistant CCRF-CEM NV3McVcxS3m2b4TvfIlkcXS7IHHzd4F6 NULuRlQzPzJiaB?= MX3JR|UxKD1iMT6yJO69VQ>? NGe0ZVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW3Olc5PSd-MUm1O|Y4QDV:L3G+
MCF7 MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn\2OFghcA>? MVHJR|UxKD1iMD6wNFMh|ryP M1\qdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkCxOVk1Lz5zOU[wNVU6PDxxYU6=
PtK2 M1rue2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4ToZ2lEPTBiPTCwMlAzOSEQvF2= NWqyV29ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2NFE2QTRpPkG5OlAyPTl2PD;hQi=>
rat A10 NEnZcGtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJR|UxKD1iMD6wN|gh|ryP M{W2[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NkCxOVk1Lz5zOU[wNVU6PDxxYU6=
HCT116 MkLSRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NYrERpR6PzJiaB?= M{jTS2lEPTBiPTCwMlAxODhizszN NX3xXpo3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2OlU{QDRpPkG5OlY2Ozh2PD;hQi=>
PC3 NWi4TWU4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NF70b2Y4OiCq NFj3PVlKSzVyIE2gNE4xODB6IN88US=> M{LGflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7Nk[1N|g1Lz5zOU[2OVM5PDxxYU6=
NCI/ADR MnTQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MU[3NkBp M2XBd2lEPTBiPTCwMlAxPCEQvF2= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ4NUO4OEc,OTl4NkWzPFQ9N2F-
HuH7 NEnKOFZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MlraO|IhcA>? MXXJR|UxKD1iMD6wNFgh|ryP M3ThfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7Nk[1N|g1Lz5zOU[2OVM5PDxxYU6=
Caco-2 NWP2NHpqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3rkPVczKGh? MoToTWM2OCB;IECuNFIh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTZ4NUO4OEc,OTl4NkWzPFQ9N2F-
MES-SA/Dx5 NXG1S5I2S3m2b4TvfIlkcXS7IHHzd4F6 MUnJR|UxKD1iNz61N|gh|ryP Mlz0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4N{m0O|UoRjF7Nke5OFc2RC:jPh?=
A549 NH7iNWlEgXSxdH;4bYNqfHliYYPzZZk> NXztNnFCUUN3MDC9JFAvODB{MzFOwG0> MkTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MEi2O|koRjF7N{C4Olc6RC:jPh?=
BGC823 NUTtWo9rS3m2b4TvfIlkcXS7IHHzd4F6 M2nX[GlEPTBiPTCwMlAxOzNizszN NUT0PJI4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NFg3PzlpPkG5O|A5Pjd7PD;hQi=>
HCT8 NXzrfmJJS3m2b4TvfIlkcXS7IHHzd4F6 MkPyTWM2OCB;IECuNFA{PiEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyOE[3PUc,OTl5MEi2O|k9N2F-
A2780 NF23dIdEgXSxdH;4bYNqfHliYYPzZZk> MoHGTWM2OCB;IECuNFA4QSEQvF2= NVP2RmQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NFg3PzlpPkG5O|A5Pjd7PD;hQi=>
Bel7404 MlHIR5l1d3SxeHnjbZR6KGG|c3H5 MXjJR|UxKD1iMD6wNVI{KM7:TR?= MlvBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MEi2O|koRjF7N{C4Olc6RC:jPh?=
DG75 M3rN[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mn36NlQhfG9iN{KgbC=> NWHF[4NuUUN3MDC9JFAvODFizszN M3ixblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{G3NlE2Lz5zOUexO|IyPTxxYU6=
MUTU-I NIL0bJpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml\hNlQhcA>? NW\XfXhvUUN3MDC9JFAvODFizszN NV7GO5JbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NVczOTVpPkG5O|E4OjF3PD;hQi=>
HCT116 NUSxWYw5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MV63NkBp MVLJR|UxKD1iMD6wNFEh|ryP MlflQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEO4OlMoRjF7N{SzPFY{RC:jPh?=
SW48 Mn3rRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M1rjOlczKGh? NIHwfHdKSzVyIE2gNE4xODFizszN MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2M{i2N{c,OTl5NEO4OlM9N2F-
MES-SA Ml\rRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NILHbFE4OiCq M1nGT2lEPTBiPTCwMlAxOSEQvF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2M{i2N{c,OTl5NEO4OlM9N2F-
CEM MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MorDO|IhcA>? M4e4O2lEPTBiPTCwMlAxOiEQvF2= NG[zTmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0N|g3Oyd-MUm3OFM5PjN:L3G+
SW480 NGn0WVJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MorqO|IhcA>? NI\qV|JKSzVyIE2gNE4xODJizszN M2PQSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{SzPFY{Lz5zOUe0N|g3OzxxYU6=
MCF7 NGLZZVFEgXSxdH;4bYNqfHliYYPzZZk> Mo\MO|IhcA>? NEW1WY1KSzVyIE2gNE4xODNizszN NIjVRog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0N|g3Oyd-MUm3OFM5PjN:L3G+
RL MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M2TDblczKGh? M2nzOmlEPTBiPTCwMlAxOyEQvF2= NEfoZWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0N|g3Oyd-MUm3OFM5PjN:L3G+
T47D MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{DFeFczKGh? NFf6fWFKSzVyIE2gNE4xODRizszN NHrCN3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0N|g3Oyd-MUm3OFM5PjN:L3G+
UACC-812 M3vUXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYHKWnlyPzJiaB?= MXrJR|UxKD1iMD63JO69VQ>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2M{i2N{c,OTl5NEO4OlM9N2F-
DU145 MUjDfZRwfG:6aXPpeJkh[XO|YYm= Ml\tO|IhcA>? NXjNPJBHUUN3MDC9JFQvQDRizszN MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd3NEGzNEc,OTl5NUSxN|A9N2F-
LNCAP M3\6SWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHP0c5A4OiCq MYLJR|UxKD1iNj6zNkDPxE1? M{DGbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{W0NVMxLz5zOUe1OFE{ODxxYU6=
HT-29 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NE\3fWoyKGh? NEe0PYVKSzVyIE2gNE4xODN2IN88US=> NETlfYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe3PFA3Pyd-MUm3O|gxPjd:L3G+
HCT116 M{HwPWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVSxJIg> NYfCdph1UUN3MDC9JFAvODB|NTFOwG0> NGLDUJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe3PFA3Pyd-MUm3O|gxPjd:L3G+
K562 NHSyV2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml7mOFghcA>? NYrMZ4o5UUN3MDC9JFEvOTZizszN M1;nVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEG1N|E3Lz5zOUixOVMyPjxxYU6=
A549 M1PlO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUG0PEBp MUfJR|UxKD1iMj6yPEDPxE1? Ml7UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MUWzNVYoRjF7OEG1N|E3RC:jPh?=
SGC7901 NHX4RWZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGLpfHc1QCCq MWLJR|UxKD1iMz6zOEDPxE1? Mlf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MUWzNVYoRjF7OEG1N|E3RC:jPh?=
HCT116 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlPqOFghcA>? NHPZfFlKSzVyIE2gOE4{PyEQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThzNUOxOkc,OTl6MUWzNVY9N2F-
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Bel7402 NXfmO3RpS3m2b4TvfIlkcXS7IHHzd4F6 NInGSFU6PiCq M2e1[GlEPTBiPTC2MlMh|ryP M1W5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNU[wOlQ4Lz5{MEW2NFY1PzxxYU6=
A2780 NXLKSFM1S3m2b4TvfIlkcXS7IHHzd4F6 MVyzJIRigXN? MY\JR|UxKD1iMD62OUDPxE1? MnjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3OUO4N|koRjJyNUmzPFM6RC:jPh?=
HCT8 NFrHVFdEgXSxdH;4bYNqfHliYYPzZZk> NU\6XIFKOyCmYYnz M4rZO2lEPTBiPTCwMlY4KM7:TR?= M2TjR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUmzPFM6Lz5{MEW5N|g{QTxxYU6=
Bel7402 MkHwR5l1d3SxeHnjbZR6KGG|c3H5 M2jFOlMh\GG7cx?= NFjUOXZKSzVyIE2gNU45KM7:TR?= M4D2R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUmzPFM6Lz5{MEW5N|g{QTxxYU6=
KB NUXJZow3S3m2b4TvfIlkcXS7IHHzd4F6 MoXKTWM2OCB;IECuNFgh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{N{eyNUc,OjB4Mke3NlE9N2F-
786-0 MnP6R5l1d3SxeHnjbZR6KGG|c3H5 Ml3JTWM2OCB;IECuNFgh|ryP MoftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4Mke3NlEoRjJyNkK3O|IyRC:jPh?=
HepG2 NIH5XHBEgXSxdH;4bYNqfHliYYPzZZk> NHTUXHdKSzVyIE2gNE4xQCEQvF2= M3jrUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK3O|IyLz5{ME[yO|czOTxxYU6=
OS-RC2 NEXpT2NEgXSxdH;4bYNqfHliYYPzZZk> NXj5ZmlDUUN3MDC9JFAvODhizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{N{eyNUc,OjB4Mke3NlE9N2F-
22Rv1 MmHSR5l1d3SxeHnjbZR6KGG|c3H5 Mn70TWM2OCB;IECuNFgh|ryP NFHrWJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
HT-29 NGTpd4hEgXSxdH;4bYNqfHliYYPzZZk> NVj2U3Z3UUN3MDC9JFAvOzhizszN Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB4Mke3NlEoRjJyNkK3O|IyRC:jPh?=
A375 NELxS41EgXSxdH;4bYNqfHliYYPzZZk> MorOTWM2OCB;IECuPFEh|ryP NH\odoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
MCF7 MlvSR5l1d3SxeHnjbZR6KGG|c3H5 NFLQem1KSzVyIE2gNU4{KM7:TR?= NH\LemU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
BCG823 NGT5NYZEgXSxdH;4bYNqfHliYYPzZZk> MoDhTWM2OCB;IEGuOUDPxE1? NWf6eW9yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2Nlc4OjFpPkKwOlI4PzJzPD;hQi=>
769-P MXrDfZRwfG:6aXPpeJkh[XO|YYm= Mo\HTWM2OCB;IEeuNUDPxE1? M3vBe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK3O|IyLz5{ME[yO|czOTxxYU6=
KB MYjDfZRwfG:6aXPpeJkh[XO|YYm= M{PmSmlEPTBiPTCwMlA5KM7:TR?= NXjMVJRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3NVY1PjhpPkKwO|E3PDZ6PD;hQi=>
786-0 M{fkRmN6fG:2b4jpZ4l1gSCjc4PhfS=> NXrNTGFQUUN3MDC9JFAvODhizszN M2LL[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{G2OFY5Lz5{MEexOlQ3QDxxYU6=
OS-RC2 M1vjfGN6fG:2b4jpZ4l1gSCjc4PhfS=> MknrTWM2OCB;IECuNFgh|ryP MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
22Rv1 NYDFdmhwS3m2b4TvfIlkcXS7IHHzd4F6 M17jV2lEPTBiPTCwMlA5KM7:TR?= M1W3[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{G2OFY5Lz5{MEexOlQ3QDxxYU6=
HepG2 M1vPOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVTJR|UxKD1iMD6wPEDPxE1? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
HT-29 NUPSVJp2S3m2b4TvfIlkcXS7IHHzd4F6 NH\zcYFKSzVyIE2gNE4{QCEQvF2= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
A375 M3LFNGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUH0WmVlUUN3MDC9JFAvQDFizszN NYHYUmhvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3NVY1PjhpPkKwO|E3PDZ6PD;hQi=>
MCF7 NXLOZW1qS3m2b4TvfIlkcXS7IHHzd4F6 NX3JfWhqUUN3MDC9JFEvOyEQvF2= M4q2VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{G2OFY5Lz5{MEexOlQ3QDxxYU6=
BGC823 NV\t[5lbS3m2b4TvfIlkcXS7IHHzd4F6 NYjqb2N1UUN3MDC9JFEvPSEQvF2= MnKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5MU[0OlgoRjJyN{G2OFY5RC:jPh?=
769-P NYj6TXo3S3m2b4TvfIlkcXS7IHHzd4F6 NFHY[XlKSzVyIE2gO{4yKM7:TR?= M4HSeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{G2OFY5Lz5{MEexOlQ3QDxxYU6=
BGC823 NUXnboxDS3m2b4TvfIlkcXS7IHHzd4F6 MYW3NkBp NGGzdGhKSzVyIE2gNE4xODFizszN Ml;ZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5MUm1NVAoRjJyN{G5OVExRC:jPh?=
A2780 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MlvtO|IhcA>? NXXnWnB[UUN3MDC9JFAvODBzIN88US=> NWToWFlYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3NVk2OTBpPkKwO|E6PTFyPD;hQi=>
A549 M3;vNmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVLEbVlUPzJiaB?= MXXJR|UxKD1iMD6wNVYh|ryP MknzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5MUm1NVAoRjJyN{G5OVExRC:jPh?=
HCT8 MWXDfZRwfG:6aXPpeJkh[XO|YYm= MnnGO|IhcA>? MUfJR|UxKD1iMD6wOVEh|ryP M{XXXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{G5OVExLz5{MEexPVUyODxxYU6=
Bel7402 M3zofGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4PqclczKGh? MlPzTWM2OCB;IECuNFYh|ryP NX[wc3lRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3NVk2OTBpPkKwO|E6PTFyPD;hQi=>
A549 MXXDfZRwfG:6aXPpeJkh[XO|YYm= MkPOO|IhcA>? NIG5NWZKSzVyIE2gNE4xODN6IN88US=> NYLnXWZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3N|I5ODlpPkKwO|MzQDB7PD;hQi=>
HEK M1HZRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWTYXZVWPzJiaB?= MV3JR|UxKD1iMD6wNFM6KM7:TR?= MkO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5M{K4NFkoRjJyN{OyPFA6RC:jPh?=
MCF7 MWPDfZRwfG:6aXPpeJkh[XO|YYm= NUDSOY81PzJiaB?= NV7mVoZYUUN3MDC9JFAvODB2NDFOwG0> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|MkiwPUc,OjB5M{K4NFk9N2F-
HeLa MmK2R5l1d3SxeHnjbZR6KGG|c3H5 NVPW[HE6PzJiaB?= M2PGb2lEPTBiPTCwMlAxQDlizszN MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|MkiwPUc,OjB5M{K4NFk9N2F-
Hep3B NGnPXWRCdnSrY3HuZ4VzKGG|c3H5 NWHYV4RCOyCmYYnz NWXEeG9iT0l3MDC9JFAvODByNDFOwG0> MmKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5M{WxOFAoRjJyN{O1NVQxRC:jPh?=
DU145 M{mzOGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWjyO4dwTUR3MDC9JFAvODB|IN88US=> MlXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5M{ixNFMoRjJyN{O4NVA{RC:jPh?=
KB NIT2XFREgXSxdH;4bYNqfHliYYPzZZk> M1PhVmVFPTBiPTCwMlAxPyEQvF2= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|OEGwN{c,OjB5M{ixNFM9N2F-
A549 MnjrR5l1d3SxeHnjbZR6KGG|c3H5 M37Ud2VFPTBiPTCwMlAxQCEQvF2= Ml:zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5M{ixNFMoRjJyN{O4NVA{RC:jPh?=
MCF7 NVfT[Jo2S3m2b4TvfIlkcXS7IHHzd4F6 MWC3NkBp MlTiTWM2OCB;IECuNFAzKM7:TR?= NYnUd25ZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NFA2ODBpPkKwPFAxPTByPD;hQi=>
wild type LCC-6 MYnDfZRwfG:6aXPpeJkh[XO|YYm= NWnYXpJlPzJiaB?= NX24cHJTUUN3MDC9JFAvODB|IN88US=> MoLMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MEC1NFAoRjJyOECwOVAxRC:jPh?=
A2780 MWfDfZRwfG:6aXPpeJkh[XO|YYm= MWm3NkBp NFfVXGVKSzVyIE2gNE4xOiEQvF2= MmqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MEC1NFAoRjJyOECwOVAxRC:jPh?=
CFPAC-1 M2XFfWN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml;KO|IhcA>? M2niemlEPTBiPTCwMlA1PyEQvF2= M3;POlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOECwOVAxLz5{MEiwNFUxODxxYU6=
multidrug-resistant LCC-6 MnHWR5l1d3SxeHnjbZR6KGG|c3H5 NVjHVVl5PzJiaB?= NHriSYRKSzVyIE2gNE4{PzlizszN M2PxSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOECwOVAxLz5{MEiwNFUxODxxYU6=
NCI/ADR NWjXR2R[S3m2b4TvfIlkcXS7IHHzd4F6 MnPGO|IhcA>? MmLnTWM2OCB;IECuOFEh|ryP M2DVUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOECwOVAxLz5{MEiwNFUxODxxYU6=
multidrug-resistant MDA-MB-435/LCCMDR1 NXPLO3c{S3m2b4TvfIlkcXS7IHHzd4F6 M2HROVQ5KGh? MYrJR|UxKD1iMD6wNFQh|ryP NV\uO5lRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5NVk4OjBpPkKwPVE6PzJyPD;hQi=>
multidrug-resistant MDA-MB-435/LCCMDR1 M1jOSWZ2dmO2aX;uJIF{e2G7 MYDJR|UxKD1iMD6wOlk{KM7:TR?= M17OZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUG5O|IxLz5{MEmxPVczODxxYU6=
MDA-MB-435 M{Xl[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1XuUVQ5KGh? MnLLTWM2OCB;IECuNlc4KM7:TR?= M3m0PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUG5O|IxLz5{MEmxPVczODxxYU6=
LNCAP NUn5e|M2S3m2b4TvfIlkcXS7IHHzd4F6 NUfCe5AyUUN3MDC9JFAvODJ{MzFOwG0> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|Nki3OEc,OjB7M{[4O|Q9N2F-
HT-29 M3m5O2N6fG:2b4jpZ4l1gSCjc4PhfS=> NEGzXJo{KGSjeYO= NG\QUoFGTDVyIE2gNE4xODB4IN88US=> NWXh[2Y6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5N|k2PDBpPkKwPVM6PTRyPD;hQi=>
HCT116 NG\yNpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2XCO|k3KGh? MkniTWM2OCB;IECuNFAzKM7:TR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl2M{SwNUc,OjB7NEO0NFE9N2F-
HCT15 Mn7PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\4V|k3KGh? NIXhTJhKSzVyIE2gNE4yPCEQvF2= NWHYPZBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5OFM1ODFpPkKwPVQ{PDBzPD;hQi=>
HeLa NECyVW5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MoPPTWM2OCB;IECuNFAyPiEQvF2= MmTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7N{O0PFgoRjJyOUezOFg5RC:jPh?=
SKOV3 M{LxTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MWLJR|UxKD1iMD6wNFMh|ryP NV\6[GpKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5O|M1QDhpPkKwPVc{PDh6PD;hQi=>
A549 MmjoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MV65OkBp MWfJR|UxKD1iMD6wNFQ6KM7:TR?= NEfVeXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEm3OFUxPSd-MkC5O|Q2ODV:L3G+
MCF7 NGXm[HlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHfUcnU6PiCq M1q2bGlEPTBiPTCwMlAzOSEQvF2= NGjDXlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEm3OFUxPSd-MkC5O|Q2ODV:L3G+
HT-29 NFrNXFJCdnSrY3HuZ4VzKGG|c3H5 MVjFSFUxKD1iMD6wNFAyKM7:TR?= NFnuflU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC2O|IxPid-MkGwOlczODZ:L3G+
K562 NVnjZpNGS3m2b4TvfIlkcXS7IHHzd4F6 NV3YT3E4PDhiaB?= NGHKbJJKSzVyIE2gNU4yPiEQvF2= MlzSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyNke5N|MoRjJzME[3PVM{RC:jPh?=
MCF7 M4DI[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoTsOFghcA>? MWjJR|UxKD1iMj6xNUDPxE1? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB4N{mzN{c,OjFyNke5N|M9N2F-
A549 NXjnVHJJS3m2b4TvfIlkcXS7IHHzd4F6 NGLqZW81QCCq M2X5e2lEPTBiPTCyMlQ3KM7:TR?= NXfyeol1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwOlc6OzNpPkKxNFY4QTN|PD;hQi=>
SGC MkfKR5l1d3SxeHnjbZR6KGG|c3H5 NULhfVN[PDhiaB?= MoLhTWM2OCB;IEOuN|Qh|ryP NHG4O3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC2O|k{Oyd-MkGwOlc6OzN:L3G+
HCT116 MUnDfZRwfG:6aXPpeJkh[XO|YYm= NY\4RmZRPDhiaB?= NWCwPJpWUUN3MDC9JFQvOzdizszN MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB4N{mzN{c,OjFyNke5N|M9N2F-
CCRF-CEM MVrDfZRwfG:6aXPpeJkh[XO|YYm= M3LCNlczKGh? MkDTTWM2OCB;IECuNFA{KM7:TR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFyNkO3O{c,OjFzME[zO|c9N2F-
MCF7 NUjyPI5GS3m2b4TvfIlkcXS7IHHzd4F6 NHfOOXQ4OiCq M2TaTGdKPTBiPTCwMlAxOyEQvF2= M3S5eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1NlExLz5{MUGxOVIyODxxYU6=
HT-29 M1\wO2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3OzSlczKGh? Ml7DS2k2OCB;IECuNFA{KM7:TR?= NY\SeHBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVUzOTBpPkKxNVE2OjFyPD;hQi=>
K562 M{DUVmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXy3NkBp NY\MVm1{T0l3MDC9JFAvODB2IN88US=> M1zDW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1NlExLz5{MUGxOVIyODxxYU6=
PC3 MnfVR5l1d3SxeHnjbZR6KGG|c3H5 NVrPU2l5PzJiaB?= M{X3NWdKPTBiPTCwMlAxPCEQvF2= M4i0T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1NlExLz5{MUGxOVIyODxxYU6=
MCF7 NYnaT3lKS3m2b4TvfIlkcXS7IHHzd4F6 MljVNlQhcA>? NILNdo9KSzVyIE2gNE43OyEQvF2= M370cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1NlEzLz5{MUGxOVIyOjxxYU6=
SMMC7721 NFz0b|lEgXSxdH;4bYNqfHliYYPzZZk> M1TmflI1KGh? M3ywVWlEPTBiPTCxMlQzKM7:TR?= MoD4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMUWyNVIoRjJzMUG1NlEzRC:jPh?=
A2780 MVzDfZRwfG:6aXPpeJkh[XO|YYm= NGTQbJc1QCC2bzC3NkBp M{LEPWlEPTBiPTCwMlAyKM7:TR?= NEfKdHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyOlAzPyd-MkGxNlYxOjd:L3G+
Jurkat MUjD[YxtKGO7Y3zlJIFzemW|dDDhd5NigQ>? NXW0S3hUOjRiaB?= NEHs[5RKSzVyIE2gNE4xOSEQvF2= MofYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMk[wNlcoRjJzMUK2NFI4RC:jPh?=
HeLa M1n3fmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3vTSFQ5KHSxIEeyJIg> MX;JR|UxKD1iMD6wNkDPxE1? M4X2WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUK2NFI4Lz5{MUGyOlAzPzxxYU6=
SW620 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NFP3UVg1QCC2bzC3NkBp M2W1[WlEPTBiPTCwMlA{KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF{NkCyO{c,OjFzMk[wNlc9N2F-
HCT116 NVv3dGVCS3m2b4TvfIlkcXS7IHHzd4F6 NV;HZnFNPzJiaB?= MV7JR|UxKD1iMD6wNFE{KM7:TR?= NInaV4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OFc2Pid-MkGxOFQ4PTZ:L3G+
CCRF-CEM MmPsR5l1d3SxeHnjbZR6KGG|c3H5 NEPKSnE4OiCq NYPuNGFkUUN3MDC9JFAvODB|IN88US=> NEDDT4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OFc2Pid-MkGxOFQ4PTZ:L3G+
MX1 NE\NOmJEgXSxdH;4bYNqfHliYYPzZZk> NFfWTZg4OiCq NETwfGRKSzVyIE2gNE4xOzVizszN MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTF2NEe1Okc,OjFzNES3OVY9N2F-
chemoresistant DG75 MWnDfZRwfG:6aXPpeJkh[XO|YYm= NVXpTWNYPzJiaB?= NWXtdWNwUUN3MDC9JFAvODFizszN M{LqclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkK3O|AzLz5{MUKyO|cxOjxxYU6=
chemosensitive MUTU-I MVLDfZRwfG:6aXPpeJkh[XO|YYm= MWKyOEBp Mn7UTWM2OCB;IECuNFEh|ryP NF3lclY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKyO|cxOid-MkGyNlc4ODJ:L3G+
HT1080 M3XWOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M1PPOFk3KGh? MVHJR|UxKD1iMD6wNFEzKM7:TR?= M2j0c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm2OFY4Lz5{MUK5OlQ3PzxxYU6=
A549 M3G5OGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NH72eXQ6PiCq M1mxfWlEPTBiPTCwMlAxPDRizszN NYfYPVJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVY1PjdpPkKxNlk3PDZ5PD;hQi=>
A375 NIi5NWZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEjFSmM6PiCq MnXUTWM2OCB;IECuNFA1PiEQvF2= NWft[YtKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVY1PjdpPkKxNlk3PDZ5PD;hQi=>
NCI-N87 M17oV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVO5OkBp NGHte2pKSzVyIE2gNE4xODV7IN88US=> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkS2O{c,OjF{OU[0Olc9N2F-
MCF7 NYPVZ2ZPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3PMbVk3KGh? MnjXTWM2OCB;IECuNFIxPSEQvF2= MnjQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OU[0OlcoRjJzMkm2OFY4RC:jPh?=
HeLa NYHoUYc{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEm3T4U6PiCq M4fBdGlEPTBiPTCwMlEh|ryP M37mRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm2OFY4Lz5{MUK5OlQ3PzxxYU6=
PANC1 NW[zZmtkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYXreHRKQTZiaB?= M3fwZ2lEPTBiPTCwMlM5PDFizszN M1LvU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm2OFY4Lz5{MUK5OlQ3PzxxYU6=
Bel7402 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWX2e2w2QTZiaB?= MX;JR|UxKD1iMD61O|gzKM7:TR?= Mnq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OU[0OlcoRjJzMkm2OFY4RC:jPh?=
1A9 NYPaTHpySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MUizJIRigXN? NICyd4lGTDVyIE2gNE4xODJyOTFOwG0> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkW3PUc,OjF{OU[1O|k9N2F-
A549 M4\VV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MoHHN{Bl[Xm| NUjoWJBlTUR3MDC9JFAvODB{NU[g{txO MnLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OU[1O|koRjJzMkm2OVc6RC:jPh?=
KB NIHV[oxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVruPWRLOyCmYYnz MXjFSFUxKD1iMD6wNFI5PyEQvF2= M{m4[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm2OVc6Lz5{MUK5OlU4QTxxYU6=
PC3 M1rOSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmnUN{Bl[Xm| NFHUT45GTDVyIE2gNE4xODh6NzFOwG0> NFTFUYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5OlU4QSd-MkGyPVY2Pzl:L3G+
KB NUDFOHd6S3m2b4TvfIlkcXS7IHHzd4F6 NGfpWIg4OiCq Mmi3S2k2OCB;IECuNFA1QDdizszN NWDBWYFiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVY6PzdpPkKxN|E3QTd5PD;hQi=>
DU145 NV\YXYFVS3m2b4TvfIlkcXS7IHHzd4F6 MoK3O|IhcA>? NVzPUWxST0l3MDC9JFAvODB3NUWg{txO Ml;UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MU[5O|coRjJzM{G2PVc4RC:jPh?=
A549 NXz2UY4zS3m2b4TvfIlkcXS7IHHzd4F6 NXTxVXFmPzJiaB?= M1jx[2dKPTBiPTCwMlAxPTV6IN88US=> NYTtb4MzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNVY6PzdpPkKxN|E3QTd5PD;hQi=>
MES-SA NYSwcZVwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MWPJR|UxKD1iMD6wNFI6PiEQvF2= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN{NE[4Okc,OjF|MkS2PFY9N2F-
MES-SA MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4rScGlEPTBiPTCwMlAxOjl4IN88US=> NUP4[GZGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNlQ3QDdpPkKxN|I1Pjh5PD;hQi=>
SF295 M{P5UmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlXNTWM2OCB;IECuNFI1PTVizszN M4i2R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{K0Olg4Lz5{MUOyOFY5PzxxYU6=
MES-SA M1vwc2N6fG:2b4jpZ4l1gSCjc4PhfS=> MmrHTWM2OCB;IECuNFAzQTZizszN MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN{NE[5Nkc,OjF|MkS2PVI9N2F-
MCF7 MoP4R5l1d3SxeHnjbZR6KGG|c3H5 M1vTXVQ5KGh? MY\JR|UxKD1iMD6wNFYh|ryP MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN2MUexPEc,OjF|NEG3NVg9N2F-
HT-29 NWGzRndFS3m2b4TvfIlkcXS7IHHzd4F6 MYO0PEBp NIPMeGpKSzVyIE2gNE4xODdizszN M17ZUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{SxO|E5Lz5{MUO0NVcyQDxxYU6=
K562 NULpOIYzS3m2b4TvfIlkcXS7IHHzd4F6 M3nUVFQ5KGh? MnvTTWM2OCB;IEGuNVYh|ryP M{XDUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{SyO|M2Lz5{MUO0Nlc{PTxxYU6=
MCF7 NI[2b3pEgXSxdH;4bYNqfHliYYPzZZk> NGTKN3o1QCCq NILoPFBKSzVyIE2gNk4yOSEQvF2= NEXNRWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO0Nlc{PSd-MkGzOFI4OzV:L3G+
A549 M4OzN2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1zXSFQ5KGh? M2TXOGlEPTBiPTCyMlQ3KM7:TR?= NWPDbFVLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOFI4OzVpPkKxN|QzPzN3PD;hQi=>
SGC NFPUTpZEgXSxdH;4bYNqfHliYYPzZZk> Mn7BOFghcA>? NWHhU5A1UUN3MDC9JFMvOzRizszN MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN2MkezOUc,OjF|NEK3N|U9N2F-
HCT116 MlSzR5l1d3SxeHnjbZR6KGG|c3H5 NWfJTWFSPDhiaB?= M4juXmlEPTBiPTC0MlM4KM7:TR?= NX7LSXFIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOFI4OzVpPkKxN|QzPzN3PD;hQi=>
multidrug-resistant K562 M1GzbGN6fG:2b4jpZ4l1gSCjc4PhfS=> M324OVQ5KGh? NVrPWYVkUUN3MDC9JFUvPjNizszN NWfZVml6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOFI4OzVpPkKxN|QzPzN3PD;hQi=>
CCRF-CEM NF20fotEgXSxdH;4bYNqfHliYYPzZZk> MUO3NkBp NFTm[o9KSzVyIE2gNE4xODNizszN NUPHRlRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzOVY2QTJpPkKxN|U3PTl{PD;hQi=>
taxol-resistant CCRF-CEM M2DUPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVXsOZVYPzJiaB?= M{LaOmlEPTBiPTCwMlQ{KM7:TR?= NGf0doo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO1OlU6Oid-MkGzOVY2QTJ:L3G+
vinblastine-resistant CCRF-CEM MnnpR5l1d3SxeHnjbZR6KGG|c3H5 NEf2T2M4OiCq MVHJR|UxKD1iMT6yO{DPxE1? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3NkW5Nkc,OjF|NU[1PVI9N2F-
KB NV[yVYpzS3m2b4TvfIlkcXS7IHHzd4F6 NYHFPYNVOyCmYYnz NYD1[mt7T0l3MDC9JFAvODB3MU[g{txO NIDTOZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3O|M3QCd-MkGzO|c{Pjh:L3G+
DU145 NFL2SGxEgXSxdH;4bYNqfHliYYPzZZk> NGftcIk{KGSjeYO= Moq0S2k2OCB;IECuNFA2OjNizszN M133VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{e3N|Y5Lz5{MUO3O|M3QDxxYU6=
A549 MoTuR5l1d3SxeHnjbZR6KGG|c3H5 M3;tOVMh\GG7cx?= M{X0XWdKPTBiPTCwMlAxPzZizszN M2jqS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{e3N|Y5Lz5{MUO3O|M3QDxxYU6=
A2780 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NVzJW5gxOjRiaB?= NFzwXYxKSzVyIE2gNE4xODB6MjFOwG0> NETBPXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO5Olc1Pyd-MkGzPVY4PDd:L3G+
A2780AD MXHDfZRwfG:6aXPpeJkh[XO|YYm= NWru[HFCOjRiaB?= M4f5bmlEPTBiPTCwMlk1QSEQvF2= NET1OoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO5Olc1Pyd-MkGzPVY4PDd:L3G+
HT-29 MYjDfZRwfG:6aXPpeJkh[XO|YYm= MmKzN{Bl[Xm| MV\FSFUxKD1iMD6wNFAyKM7:TR?= NEHESIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSyPFM4PSd-MkG0Nlg{PzV:L3G+
MCF7 MojBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Mm\1O|IhcA>? NXnpcoRoUUN3MDC9JFAvODB{IN88US=> M2fE[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNESwOFQ6Lz5{MUS0NFQ1QTxxYU6=
HeLa NFPRdWVEgXSxdH;4bYNqfHliYYPzZZk> NX;XeHFzPDhiaB?= NUXKUnpCUUN3MDC9JFAvODB{NjFOwG0> M3vuRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNES2Olk6Lz5{MUS0OlY6QTxxYU6=
HT-29 MmHVR5l1d3SxeHnjbZR6KGG|c3H5 NW\DN3FEPDhiaB?= MYPJR|UxKD1iMD6wNFMh|ryP NHTObIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS0OlY6QSd-MkG0OFY3QTl:L3G+
KB NILJXYxE\WyuIHP5Z4xmKGG{cnXzeEBie3OjeR?= M3S2WWVEPTBiPTCwMlAxOiEQvF2= NYf6[2szRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PFA3OjZpPkKxOFgxPjJ4PD;hQi=>
A549 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYq3NkBp MmPnTWM2OCB;IECuNFAzOyEQvF2= NU\2Tnk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PFA3OjZpPkKxOFgxPjJ4PD;hQi=>
HT-29 NFnJNXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXO1OolPPzJiaB?= MWXJR|UxKD1iMD6wNFYyKM7:TR?= M2DYeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEiwOlI3Lz5{MUS4NFYzPjxxYU6=
A431 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NUXkSYY4PzJiaB?= MUfJR|UxKD1iMD6wNFkzKM7:TR?= MmD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2OEC2NlYoRjJzNEiwOlI3RC:jPh?=
SKOV3 MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NUPPVGVJPzJiaB?= NGTGbllKSzVyIE2gNE4xOTR3IN88US=> NUXDeIpyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PFA3OjZpPkKxOFgxPjJ4PD;hQi=>
NCI-H460 NHrJZYFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIDlOGo4OiCq MnjhTWM2OCB;IECuNFE1PiEQvF2= M1W3bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEiwOlI3Lz5{MUS4NFYzPjxxYU6=
MCF7 MlO3R5l1d3SxeHnjbZR6KGG|c3H5 NUe3UWpOPDhiaB?= M4TVOWdKPTBiPTCwMlAyOiEQvF2= M2\5RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUGzNlk1Lz5{MUWxN|I6PDxxYU6=
HT-29 NYDIPG1pS3m2b4TvfIlkcXS7IHHzd4F6 MXK0PEBp NUDPO49CT0l3MDC9JFAvODF{IN88US=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTVzM{K5OEc,OjF3MUOyPVQ9N2F-
SF268 NVn1[4R4S3m2b4TvfIlkcXS7IHHzd4F6 MlfVOFghcA>? NXnPNoxLT0l3MDC9JFAvODF{IN88US=> NUW1Z3ZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzQTRpPkKxOVE{Ojl2PD;hQi=>
H460 M4X1XmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIfrUIk1QCCq MWPHTVUxKD1iMD6wNlQh|ryP NWTlSnNPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVMzQTRpPkKxOVE{Ojl2PD;hQi=>
CHOK1 NHrDUIlEgXSxdH;4bYNqfHliYYPzZZk> NH7WbY81QCCq MlTjS2k2OCB;IEWuPUDPxE1? NGDldIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWxN|I6PCd-MkG1NVMzQTR:L3G+
HeLa M{Dvc2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVSyOEBp NFPFXHJKSzVyIE2gOk43OiEQvF2= M{nDNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUG0NFE2Lz5{MUWxOFAyPTxxYU6=
HELF NHHDTIlEgXSxdH;4bYNqfHliYYPzZZk> MVGyOEBp M2ezfGlEPTBiPTC3MlE4KM7:TR?= Mn3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3MUSwNVUoRjJzNUG0NFE2RC:jPh?=
SH-SY5Y MojYR5l1d3SxeHnjbZR6KGG|c3H5 NHfIcXAzPCCq Mm\PTWM2OCB;IEiuOVYh|ryP M4LzRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUG0NFE2Lz5{MUWxOFAyPTxxYU6=
BGC823 NW\L[opyS3m2b4TvfIlkcXS7IHHzd4F6 NEnkN3gzPCCq MXzJR|UxKD1iOT6yOEDPxE1? NYPhNpU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1NVQxOTVpPkKxOVE1ODF3PD;hQi=>
A2780 MmTPR5l1d3SxeHnjbZR6KGG|c3H5 MVm3NkBp MkLyTWM2OCB;IECuNFAyKM7:TR?= NUnOcmtxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1N|AzPTFpPkKxOVMxOjVzPD;hQi=>
BGC823 MUfDfZRwfG:6aXPpeJkh[XO|YYm= NI\Rc3A4OiCq NUHldHFSUUN3MDC9JFAvODBzIN88US=> NGr6XHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzNFI2OSd-MkG1N|AzPTF:L3G+
Bel7402 MnvZR5l1d3SxeHnjbZR6KGG|c3H5 NXrwbZRYPzJiaB?= M{XpfWlEPTBiPTCwMlAxPiEQvF2= NFvYO4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzNFI2OSd-MkG1N|AzPTF:L3G+
A549 NYPGTmYxS3m2b4TvfIlkcXS7IHHzd4F6 M3nSZlczKGh? MV3JR|UxKD1iMD6wNVYh|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV|MEK1NUc,OjF3M{CyOVE9N2F-
HCT8 NILob|VEgXSxdH;4bYNqfHliYYPzZZk> NFj1TI04OiCq NYTIVlRDUUN3MDC9JFAvODVzIN88US=> M4DadFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUOwNlUyLz5{MUWzNFI2OTxxYU6=
SW480 MV7DfZRwfG:6aXPpeJkh[XO|YYm= MnjyOFghcA>? NWHReodSUUN3MDC9JFAvODB6IN88US=> NFvhWWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzOFU{QSd-MkG1N|Q2Ozl:L3G+
SMMC7721 NFr1NoNEgXSxdH;4bYNqfHliYYPzZZk> NX32PI5OPDhiaB?= NHjSS5RKSzVyIE2gNE4xODhizszN NImwcok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzOFU{QSd-MkG1N|Q2Ozl:L3G+
A549 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NVvWWXE{PDhiaB?= MmfwTWM2OCB;IECuNFA5KM7:TR?= NHfWU289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUWzOFU{QSd-MkG1N|Q2Ozl:L3G+
MCF7 MVjDfZRwfG:6aXPpeJkh[XO|YYm= MWS0PEBp NWXuUplYUUN3MDC9JFAvODB6IN88US=> M1f2OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUO0OVM6Lz5{MUWzOFU{QTxxYU6=
HL60 NHSyNG9EgXSxdH;4bYNqfHliYYPzZZk> NYrjTld1PDhiaB?= MYnJR|UxKD1iMD6wNUDPxE1? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV|NEWzPUc,OjF3M{S1N|k9N2F-
OVCAR8 MYnBcpRq[2GwY3XyJIF{e2G7 MWm5OkBp MV3JR|UxKD1iMD6wNFQ4KM7:TR?= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV3N{WzPEc,OjF3NUe1N|g9N2F-
NCI/ADR-RES MWnBcpRq[2GwY3XyJIF{e2G7 MojDPVYhcA>? M33FdGlEPTBiPTC2MlI3OyEQvF2= NUjDOVlsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OVc2OzhpPkKxOVU4PTN6PD;hQi=>
NCI-H460 NEXudJNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M1\2PFQ5KGh? M2foVmlEPTBiPTCwMlAxPCEQvF2= NXTNUpAxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlM4PTBpPkKxOVY{PzVyPD;hQi=>
COLO205 NU\rRVdnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MoLhOFghcA>? MkfxTWM2OCB;IECuNFA2KM7:TR?= NX[2OZo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlM4PTBpPkKxOVY{PzVyPD;hQi=>
SKOV3 MnzMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWm4NXBVPDhiaB?= NGn0N3hKSzVyIE2gNE4xODZizszN M3zMZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNU[zO|UxLz5{MUW2N|c2ODxxYU6=
BT549 M3rOdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2\KPVQ5KGh? M{Kw[mlEPTBiPTCwMlAxPiEQvF2= NYXDe2hvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlM4PTBpPkKxOVY{PzVyPD;hQi=>
451LU NYXsTZlGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEK5ZpE1QCCq M3jZTGlEPTBiPTCwMlAxPiEQvF2= NX3o[5dCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OlM4PTBpPkKxOVY{PzVyPD;hQi=>
SW480 Mk[4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3vYRlQ5KGh? NXfsXWk6UUN3MDC9JFAvODFzIN88US=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4M{e1NEc,OjF3NkO3OVA9N2F-
DLD1 MnjRRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NYjYZWJrPDhiaB?= M2nJW2lEPTBiPTCwMlA2KM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV4M{e1NEc,OjF3NkO3OVA9N2F-
HT1080 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3nuPFQ5KGh? MYHJR|UxKD1iMD6wNFAyPSEQvF2= NXfScog4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NFQ4PDZpPkKxOlA1PzR4PD;hQi=>
CEM NGrySlBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVzSdI9VPDhiaB?= NU\POllGUUN3MDC9JFAvODByMkeg{txO MkHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MES3OFYoRjJzNkC0O|Q3RC:jPh?=
L1210 NUXaSJVwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1PsflQ5KGh? NHi2e|hKSzVyIE2gNE4xODB2IN88US=> NIfBXFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[wOFc1Pid-MkG2NFQ4PDZ:L3G+
K562 MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmfTOFghcA>? M3;nZWlEPTBiPTCwMlAxODdzIN88US=> M4XOeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkC0O|Q3Lz5{MU[wOFc1PjxxYU6=
DU145 MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3jw[FQ5KGh? MlyzTWM2OCB;IECuNFAyOyEQvF2= M3XFV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkC0O|Q3Lz5{MU[wOFc1PjxxYU6=
SKOV3 M{ewNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYTvSIFvPDhiaB?= NGTneo5KSzVyIE2gNE4xODJ4IN88US=> NUjFXo1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NFQ4PDZpPkKxOlA1PzR4PD;hQi=>
MDA-MB-231 NIjvdHFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEK1[IE1QCCq MY\JR|UxKD1iMD6wNFkyKM7:TR?= M4HYR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkC0O|Q3Lz5{MU[wOFc1PjxxYU6=
B16F0 M1TrTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGn4d441QCCq NGPvZ4hKSzVyIE2gNE4xOjhizszN MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZyNEe0Okc,OjF4MES3OFY9N2F-
P388D1 Mmn0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVO0PEBp MW\JR|UxKD1iMD6wN|Uh|ryP NV7QW4JNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NFQ4PDZpPkKxOlA1PzR4PD;hQi=>
CHO-VV 3-2 NF7o[XFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEGxWXY1QCCq Ml;QTWM2OCB;IECuNVQh|ryP MmrQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4MES3OFYoRjJzNkC0O|Q3RC:jPh?=
CHO MmrQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVG0PEBp M3PaNWlEPTBiPTCwMlE4KM7:TR?= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZyNEe0Okc,OjF4MES3OFY9N2F-
CHO-TAX 5-6 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MlH3OFghcA>? M1i0dGlEPTBiPTCwMlUzKM7:TR?= NX7mW5drRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NFQ4PDZpPkKxOlA1PzR4PD;hQi=>
CEM/VLB Mo\5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NF76bXg1QCCq M136[WlEPTBiPTCzMlM1KM7:TR?= NIH1UFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[wOFc1Pid-MkG2NFQ4PDZ:L3G+
A549 MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NV;iWo9nPzJiaB?= NGjDXnFKSzVyIE2gNE4xODd{IN88US=> NXnWWo1sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OlM{OTlpPkKxOlY{OzF7PD;hQi=>
taxol-resistant A549-T12 MnvhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkfnO|IhcA>? NFTGfJZKSzVyIE2gNE4xPzV{IN88US=> MkjRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NkOzNVkoRjJzNk[zN|E6RC:jPh?=
MCF7 NFXpe5pEgXSxdH;4bYNqfHliYYPzZZk> NYOzOGNkPDhiaB?= NEDQSpVKSzVyIE2gNE4xODJ3IN88US=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ6MEG5NEc,OjF4OECxPVA9N2F-
MCF7/VP MkHBR5l1d3SxeHnjbZR6KGG|c3H5 NEXV[mw1QCCq MnOwTWM2OCB;IECuNFAzQCEQvF2= NF;jTpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[4NFE6OCd-MkG2PFAyQTB:L3G+
NCI/ADR NWHyd3RDS3m2b4TvfIlkcXS7IHHzd4F6 M2fK[FQ5KGh? MnzjTWM2OCB;IEKuO{DPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ6MEG5NEc,OjF4OECxPVA9N2F-
LT12 MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3XvWlQ5KGh? MmW0TWM2OCB;IECuNFA3KM7:TR?= MkfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEWyNlMoRjJzN{C1NlI{RC:jPh?=
NCI-H460 M1r4OGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFLJR5I1QCCq NX[xdVduUUN3MDC9JFAvODFizszN MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyNUKyN{c,OjF5MEWyNlM9N2F-
SF268 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MXq0PEBp MWnJR|UxKD1iMD6wNUDPxE1? NF7jcGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
KB/HeLa MoHFR5l1d3SxeHnjbZR6KGG|c3H5 M4nlPFQ5KGh? M{PnfWlEPTBiPTCwMlAyKM7:TR?= NF[4SpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
SKOV3 M3LadWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUC0PEBp NFvxdm1KSzVyIE2gNE4xOSEQvF2= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyNUKyN{c,OjF5MEWyNlM9N2F-
RKOp27 NX7h[|ZFS3m2b4TvfIlkcXS7IHHzd4F6 NGjVXpU1QCCq NVvvPJFIUUN3MDC9JFAvODFizszN M1fUZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C1NlI{Lz5{MUewOVIzOzxxYU6=
P388 MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3P0NFQ5KGh? M3TKS2lEPTBiPTCwMlA1KM7:TR?= NWfpdlRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NFUzOjNpPkKxO|A2OjJ|PD;hQi=>
L1210 M2raW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NG\ncJk1QCCq NIPUc4dKSzVyIE2gNE4xPiEQvF2= MnO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEWyNlMoRjJzN{C1NlI{RC:jPh?=
NCI-H460 Mor6RY51cWOjbnPldkBie3OjeR?= M3XacVczKGh? NFq3cWdKSzNyIE2gN{43KM7:TR?= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyN{C0Okc,OjF5MEewOFY9N2F-
A2780 NUf0NW1lS3m2b4TvfIlkcXS7IHHzd4F6 M4fqTVQ5KGh? NW\ybJBCUUN3MDC9JFAvODByNkKg{txO MnXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5NkSzNFgoRjJzN{[0N|A5RC:jPh?=
A2780AD NVvEcYhvS3m2b4TvfIlkcXS7IHHzd4F6 NHzwPWw1QCCq NYDKUWw5UUN3MDC9JFEvQSEQvF2= Mn34QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5NkSzNFgoRjJzN{[0N|A5RC:jPh?=
786-0 M2\kdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXj3ZppnUUN3MDC9JFAvODB2IN88US=> NH3YbGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OFQ6QSd-MkG3O|Q1QTl:L3G+
PC3 M1TnTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHfUZphKSzVyIE2gNE4xODB2MzFOwG0> NHHQTIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OVE2OCd-MkG3O|UyPTB:L3G+
DU145 Mlm5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Mk\3TWM2OCB;IECuNFAzOyEQvF2= NGfoO4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OVE2OCd-MkG3O|UyPTB:L3G+
MDA-MB-435 Mk\hRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXHMTFFNUUN3MDC9JFAvODF4IN88US=> M2\zd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e1NVUxLz5{MUe3OVE2ODxxYU6=
MCF7 M1rH[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M1zWXVQ5KGh? M4rJemlEPTBiPTCwMlAxOTZ{IN88US=> NYnyNppvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3O|k2OTlpPkKxO|c6PTF7PD;hQi=>
COLO205 MkjNR5l1d3SxeHnjbZR6KGG|c3H5 MWS0PEBp NEexdVBKSzVyIE2gNE4xODN|MTFOwG0> M3HxZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e5OVE6Lz5{MUe3PVUyQTxxYU6=
KB MnPqR5l1d3SxeHnjbZR6KGG|c3H5 M3fDbWlEPTBiPTC2MlY5PCEQvF2= MlrOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5OES2N|EoRjJzN{i0OlMyRC:jPh?=
DU145 M1rje2N6fG:2b4jpZ4l1gSCjc4PhfS=> M33RdmlEPTBiPTC4MlYzPiEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd6NE[zNUc,OjF5OES2N|E9N2F-
A549 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NXHFXYVXUUN3MDC9JFkvOjZ3IN88US=> NVX6NopPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3PFQ3OzFpPkKxO|g1PjNzPD;hQi=>
HeLa MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mo\oTWM2OCB;IECuNFAyOzhizszN MkPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5OE[3PVMoRjJzN{i2O|k{RC:jPh?=
SKOV3 MoroRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYLJR|UxKD1iMD6wNFI6PSEQvF2= Mlz1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5OE[3PVMoRjJzN{i2O|k{RC:jPh?=
HeLa MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXzKfpZEPDhiaB?= NVjXTpJXUUN3MDC9JFAvODBzMjFOwG0> NF7tT4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUiwNFg{QSd-MkG4NFA5Ozl:L3G+
A2780 NYT3Oph7S3m2b4TvfIlkcXS7IHHzd4F6 NFrBbG4zKGSjeYO= NY\0SHFbUUN3MDC9JFAvODF2IN88US=> MoC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MEK5OVcoRjJzOECyPVU4RC:jPh?=
Hep3B2 NWrEZmdGS3m2b4TvfIlkcXS7IHHzd4F6 MVu3NkBp M2TNfGlEPTBiPTCwMlAxODBzNjFOwG0> MnjWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NVAoRjJzOEGyOFExRC:jPh?=
PANC1 Ml\GR5l1d3SxeHnjbZR6KGG|c3H5 MlrPO|IhcA>? MknQTWM2OCB;IECuNFAyOSEQvF2= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSxNEc,OjF6MUK0NVA9N2F-
CNE1-LMP1 M1zNU2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYe3NkBp NGTKb5BKSzVyIE2gNE4xODR{IN88US=> NV\ufldnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NVI1OTBpPkKxPFEzPDFyPD;hQi=>
MGC M3vuUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVvRR5l4PzJiaB?= MUnJR|UxKD1iMD6wNFY1KM7:TR?= NVTLN4NSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NVI1OTBpPkKxPFEzPDFyPD;hQi=>
A375 MkHYR5l1d3SxeHnjbZR6KGG|c3H5 NXLhTJFTPzJiaB?= MmnYTWM2OCB;IECuNFA5QSEQvF2= NHrFdGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQyOCd-MkG4NVI1OTB:L3G+
MCF7 NXzEWXJLS3m2b4TvfIlkcXS7IHHzd4F6 M2KweVczKGh? Ml7oTWM2OCB;IECuNFE1KM7:TR?= NHKweoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQyOCd-MkG4NVI1OTB:L3G+
HaCaT MlnRR5l1d3SxeHnjbZR6KGG|c3H5 MXK3NkBp M4G2NWlEPTBiPTCwMlAzPCEQvF2= MkHXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NVAoRjJzOEGyOFExRC:jPh?=
A549 MVHDfZRwfG:6aXPpeJkh[XO|YYm= MnfnO|IhcA>? MVTJR|UxKD1iMD6wN{DPxE1? M3ezN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEGyOFExLz5{MUixNlQyODxxYU6=
EC109 NFq1VHZEgXSxdH;4bYNqfHliYYPzZZk> NX;UXZByPzJiaB?= NVzVeI9KUUN3MDC9JFAvOTRizszN NHvFWIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQyOCd-MkG4NVI1OTB:L3G+
MES-SA M3PFZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUHtbpduQTZiaB?= NYLoW2V1UUN3MDC9JFAvODB2IN88US=> NUKyOIdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4NVI1OjFpPkKxPFEzPDJzPD;hQi=>
MES-SA/Dx5 NYjDPHVFS3m2b4TvfIlkcXS7IHHzd4F6 MYi5OkBp M3\wcGlEPTBiPTCwMlc2KM7:TR?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSyNUc,OjF6MUK0NlE9N2F-
HT-29 NFXZVlNEgXSxdH;4bYNqfHliYYPzZZk> NVr2Nok3T0l3MDC9JFAvODB{IN88US=> NXzSeWg3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
RPMI8226 NWDvd251S3m2b4TvfIlkcXS7IHHzd4F6 MkDDS2k2OCB;IECuNFAzKM7:TR?= NU\5SWV{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
HCC2998 NVz2OXpOS3m2b4TvfIlkcXS7IHHzd4F6 M2XrXGdKPTBiPTCwMlAxOyEQvF2= M1TlVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEO5OlQxLz5{MUizPVY1ODxxYU6=
Hs578T NFLQRpVEgXSxdH;4bYNqfHliYYPzZZk> MV7HTVUxKD1iMD6wNFMh|ryP MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh|OU[0NEc,OjF6M{m2OFA9N2F-
COLO205 NE\WWY1EgXSxdH;4bYNqfHliYYPzZZk> M1HPe2dKPTBiPTCwMlAxOyEQvF2= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh|OU[0NEc,OjF6M{m2OFA9N2F-
PC3 NXrQRVZjS3m2b4TvfIlkcXS7IHHzd4F6 NGfxWnRIUTVyIE2gNE4xODRizszN MkHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6M{m2OFAoRjJzOEO5OlQxRC:jPh?=
A549 M1PpRWN6fG:2b4jpZ4l1gSCjc4PhfS=> MkD6S2k2OCB;IECuNFA1KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh|OU[0NEc,OjF6M{m2OFA9N2F-
SNB75 MkHqR5l1d3SxeHnjbZR6KGG|c3H5 Mlu2S2k2OCB;IECuNFA1KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh|OU[0NEc,OjF6M{m2OFA9N2F-
KM12 MljKR5l1d3SxeHnjbZR6KGG|c3H5 NGmyNItIUTVyIE2gNE4xODRizszN NEexZ409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUizPVY1OCd-MkG4N|k3PDB:L3G+
DU145 MWjDfZRwfG:6aXPpeJkh[XO|YYm= NVPVTXdLT0l3MDC9JFAvODB3IN88US=> M1PtNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEO5OlQxLz5{MUizPVY1ODxxYU6=
SKOV3 MXzDfZRwfG:6aXPpeJkh[XO|YYm= M4LDXmdKPTBiPTCwMlAxQCEQvF2= MnftQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6M{m2OFAoRjJzOEO5OlQxRC:jPh?=
NCI-H322M MUTDfZRwfG:6aXPpeJkh[XO|YYm= NXTMfHVjT0l3MDC9JFAvODF|IN88US=> NVT0PYZ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
UACC257 M1fVN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MnfCS2k2OCB;IECuNFQh|ryP NX\GcJVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
HCT15 NVfkU4dGS3m2b4TvfIlkcXS7IHHzd4F6 NHPFWnFIUTVyIE2gNE4yPThizszN NXPDbG4xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
ACHN NED1VYNEgXSxdH;4bYNqfHliYYPzZZk> M2\3VGdKPTBiPTCwMlM6QCEQvF2= NYriN28yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
HL60 NYPlTIx4S3m2b4TvfIlkcXS7IHHzd4F6 MnjoO|IhcA>? M{fMWmlEPTBiPTCwMlAxOzRizszN NUPET3Z2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4OFgzPjhpPkKxPFQ5OjZ6PD;hQi=>
MCF7 NI\aXVFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NV;odXdJQTZiaB?= M4\VSWlEPTBiPTCwMlAxODlzIN88US=> M{DEW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEewO|k2Lz5{MUi3NFc6PTxxYU6=
A549 Mlq2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MXK3NkBp MXfJR|UxKD1iMD6wNFMyPCEQvF2= M2D6VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEewO|k2Lz5{MUi3NFc6PTxxYU6=
A549 MUPDfZRwfG:6aXPpeJkh[XO|YYm= MUWyOEBp MofLSWM2OCB;IECuNFA1PiEQvF2= M37Pb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEezNFY5Lz5{MUi3N|A3QDxxYU6=
KB NIDrfZREgXSxdH;4bYNqfHliYYPzZZk> MWPJR|UxKD1iMD6wPEDPxE1? NIP5TmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3OVc3PCd-MkG4O|U4PjR:L3G+
786-0 MX\DfZRwfG:6aXPpeJkh[XO|YYm= MojTTWM2OCB;IECuNFgh|ryP NW\MfHllRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
OS-RC2 MVPDfZRwfG:6aXPpeJkh[XO|YYm= M{XRdGlEPTBiPTCwMlA5KM7:TR?= NU\pTWlyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
22Rv1 M3u1WmN6fG:2b4jpZ4l1gSCjc4PhfS=> MX;JR|UxKD1iMD6wPEDPxE1? NV3YSFA3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
HepG2 NFvPOoREgXSxdH;4bYNqfHliYYPzZZk> NVSw[olpUUN3MDC9JFAvODhizszN NH;POXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3OVc3PCd-MkG4O|U4PjR:L3G+
HT-29 NE\6TlREgXSxdH;4bYNqfHliYYPzZZk> NGTSeZZKSzVyIE2gNE4{QCEQvF2= M3rkdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe1O|Y1Lz5{MUi3OVc3PDxxYU6=
A375 MWLDfZRwfG:6aXPpeJkh[XO|YYm= MoLkTWM2OCB;IECuPFEh|ryP MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUe2OEc,OjF6N{W3OlQ9N2F-
MCF7 MX3DfZRwfG:6aXPpeJkh[XO|YYm= M3rjNWlEPTBiPTCxMlMh|ryP MofPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W3OlQoRjJzOEe1O|Y1RC:jPh?=
BGC823 NULsc5E3S3m2b4TvfIlkcXS7IHHzd4F6 MmrnTWM2OCB;IEGuOUDPxE1? NFfGZmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3OVc3PCd-MkG4O|U4PjR:L3G+
769-P M1TkdmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYrJR|UxKD1iNz6xJO69VQ>? Ml\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W3OlQoRjJzOEe1O|Y1RC:jPh?=
MCF7 MY\DfZRwfG:6aXPpeJkh[XO|YYm= NWS2TXlUOyCmYYnz MXvHTVUxKD1iMT6wO{DPxE1? M4TPOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi5N|QyLz5{MUi4PVM1OTxxYU6=
PC3 MmDJR5l1d3SxeHnjbZR6KGG|c3H5 MWezJIRigXN? NE\hW5JIUTVyIE2gNU41PiEQvF2= NXHxNFZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4PFk{PDFpPkKxPFg6OzRzPD;hQi=>
SK-N-SH NH\uU3pEgXSxdH;4bYNqfHliYYPzZZk> NUKxOZlOOyCmYYnz MV7HTVUxKD1iMj6xPUDPxE1? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh6OUO0NUc,OjF6OEmzOFE9N2F-
HeLa NUDCZ4VqS3m2b4TvfIlkcXS7IHHzd4F6 MWqzJIRigXN? Ml\WS2k2OCB;IEKuPFIh|ryP MmD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6OEmzOFEoRjJzOEi5N|QyRC:jPh?=
CHO-VV 3-2 MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoP1OFghcA>? MoLJTWM2OCB;IECuNVQh|ryP NHXuT3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmyNFY{QCd-MkG5NlA3Ozh:L3G+
CHO-TAX 5-6 M2XSbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGDQVo81QCCq MoTPTWM2OCB;IECuOVIh|ryP NWr0T3pVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NlA3OzhpPkKxPVIxPjN6PD;hQi=>
multidrug-resistant CEM/VLB NVH0V3NNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NX\BOY13PDhiaB?= MlvFTWM2OCB;IEOuN|Qh|ryP NYLEcFNZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NlA3OzhpPkKxPVIxPjN6PD;hQi=>
BGC823 NVfrVlNPS3m2b4TvfIlkcXS7IHHzd4F6 NYm5VVVqUUN3MDC9JFAvODB|Mkmg{txO MkLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7Mki3PVcoRjJzOUK4O|k4RC:jPh?=
HT-29 NFTPO|BEgXSxdH;4bYNqfHliYYPzZZk> NVeyeZB5UUN3MDC9JFAvODB|OUSg{txO NFvJRmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmyPFc6Pyd-MkG5Nlg4QTd:L3G+
HepG2 M3nxOWN6fG:2b4jpZ4l1gSCjc4PhfS=> MWfJR|UxKD1iMD6wNFQ1KM7:TR?= NFi3[G89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmyPFc6Pyd-MkG5Nlg4QTd:L3G+
A375 M2LldWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2PKWGlEPTBiPTCwMlAxPDlizszN MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl{OEe5O{c,OjF7Mki3PVc9N2F-
A549 MULDfZRwfG:6aXPpeJkh[XO|YYm= M33pVGlEPTBiPTCwMlA1PDlizszN Mn;hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7Mki3PVcoRjJzOUK4O|k4RC:jPh?=
NCI-H460 M1OxW2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2CyU2lEPTBiPTC4JO69VQ>? NWS3b5VXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OFI4PjVpPkKxPVQzPzZ3PD;hQi=>
A549 MlnsR5l1d3SxeHnjbZR6KGG|c3H5 MX60PEBp NXT0OnVMUUN3MDC9JFAvODFizszN M1PUWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUezNFU1Lz5{MUm3N|A2PDxxYU6=
HeLa NU\rS2pLS3m2b4TvfIlkcXS7IHHzd4F6 MWO0PEBp NVH4UmoyUUN3MDC9JFAvPiEQvF2= MnHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7N{OwOVQoRjJzOUezNFU1RC:jPh?=
HT-29 NWPaVG9oS3m2b4TvfIlkcXS7IHHzd4F6 MUGzJIRigXN? M2rBd2VFPTBiPTCwMlAxPiEQvF2= M3jtbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUezNVAyLz5{MUm3N|ExOTxxYU6=
HBL100 MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEXlWlBIUTVyIE2gNE4xODByMUeg{txO MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NkW4OUc,OjF7OE[1PFU9N2F-
HeLa MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3[xXmdKPTBiPTCwMlAxODB|MzFOwG0> NF;GNJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm4OlU5PSd-MkG5PFY2QDV:L3G+
T47D Mlm0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYDHTVUxKD1iMD6wNFAyPSEQvF2= M3PCTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUi2OVg2Lz5{MUm4OlU5PTxxYU6=
WiDr MmjzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M13UdGdKPTBiPTCwMlAxODJ{IN88US=> NV\lSm5{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5PFY2QDVpPkKxPVg3PTh3PD;hQi=>
A2780 Mmi1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIPUNIZIUTVyIE2gNE4xODB{NzFOwG0> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NkW4OUc,OjF7OE[1PFU9N2F-
SW1573 M{LObmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFLGTIVIUTVyIE2gNE4xODVizszN NGDjTpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm4OlU5PSd-MkG5PFY2QDV:L3G+
A2780 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NEGyXVdKSzVyIE2gNE4xOTdizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl7NUW0Nkc,OjF7OUW1OFI9N2F-
A549 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NE\aUXU4OiCq MVnJR|UxKD1iMD6wNFczKM7:TR?= NYfJS3ZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNlcyODBpPkKyNFI4OTByPD;hQi=>
taxol-resistant A549-T12 NGPyXHNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NULiWXFYPzJiaB?= M2\BbmlEPTBiPTCwMlA4PSEQvF2= M2nzfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEK3NVAxLz5{MkCyO|ExODxxYU6=
OVCAR8 NHjzUI5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXW5OkBp MX\JR|UxKD1iMD6wNFIh|ryP NILHXmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC0OFE3PCd-MkKwOFQyPjR:L3G+
NCI-ADR-RES MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkXVPVYhcA>? NIHiWplKSzVyIE2gNU42KM7:TR?= Ml3EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNESxOlQoRjJ{MES0NVY1RC:jPh?=
KB M{X4NWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUC3NkBp MUPJR|UxKD1iMD6wNFM{KM7:TR?= MkXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNkCwN|MoRjJ{ME[wNFM{RC:jPh?=
KB-7d MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnzhO|IhcA>? MUfJR|UxKD1iMD6wNFc6KM7:TR?= M{fy[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{ME[wNFM{Lz5{MkC2NFA{OzxxYU6=
KB-S15 MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPD[m15PzJiaB?= MYTJR|UxKD1iMD6yO|Mh|ryP MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB4MECzN{c,OjJyNkCwN|M9N2F-
A2780 NVHi[4pESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3n6OlIh\GG7cx?= NFLwNIFKSzVyIE2gNE4xOTVizszN NVPnWmMyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwO|E2OjZpPkKyNFcyPTJ4PD;hQi=>
KB MnLIR5l1d3SxeHnjbZR6KGG|c3H5 NGCxXHQ1QCCq MnviTWM2OCB;IECuNFA1PSEQvF2= NHjUcog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC3OFI2Pyd-MkKwO|QzPTd:L3G+
L1210 M3XRXGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4fzXVQ5KGh? M{nsVGlEPTBiPTCwMlEzKM7:TR?= M1rTUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEe0NlU4Lz5{MkC3OFI2PzxxYU6=
A2780 NWfl[5ltSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NUTQdFd2OiCmYYnz NUfN[Y5RUUN3MDC9JFAvODJizszN NUW2OYVwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|Y2OjNpPkKyNVM3PTJ|PD;hQi=>
DU145 MXnDfZRwfG:6aXPpeJkh[XO|YYm= NYGwPIxqTUN3MDC9JFAvODB3OTFOwG0> M2DORlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUSyOVQ{Lz5{MkG0NlU1OzxxYU6=
KB MXjDfZRwfG:6aXPpeJkh[XO|YYm= MW\FR|UxKD1iMD6wNFYh|ryP MlmwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNEK1OFMoRjJ{MUSyOVQ{RC:jPh?=
A549 MoDZR5l1d3SxeHnjbZR6KGG|c3H5 M2r3cGVEPTBiPTCwMlAxPjRizszN NFvufpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0NlU1Oyd-MkKxOFI2PDN:L3G+
QGY7701 MlTnR5l1d3SxeHnjbZR6KGG|c3H5 M2myTFczKGh? NIW5[VRKSzVyIE2gNE4xPCEQvF2= MlSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUOzN|goRjJ{MUWzN|M5RC:jPh?=
HepG2 Mnr3R5l1d3SxeHnjbZR6KGG|c3H5 M{TBeVczKGh? M1GwVGlEPTBiPTCwMlA2KM7:TR?= NHTQNnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG1N|M{QCd-MkKxOVM{Ozh:L3G+
Bel7404 NXT5NoxUS3m2b4TvfIlkcXS7IHHzd4F6 NEnLXI04OiCq NIqybmVKSzVyIE2gNE45OiEQvF2= NVHFfWdNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOVM{OzhpPkKyNVU{OzN6PD;hQi=>
SMMC7721 M1TzWWN6fG:2b4jpZ4l1gSCjc4PhfS=> M13GRVczKGh? M124UWlEPTBiPTCwMlg5KM7:TR?= NVnWfXVqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOVM{OzhpPkKyNVU{OzN6PD;hQi=>
Bel7402 M{Pk[WN6fG:2b4jpZ4l1gSCjc4PhfS=> MXy3NkBp Mn;zTWM2OCB;IEGuNlUh|ryP NGTTPZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG1N|M{QCd-MkKxOVM{Ozh:L3G+
MCF7 NGDy[FVEgXSxdH;4bYNqfHliYYPzZZk> MmCwNlQhfG9iNEigbC=> MlG4TWM2OCB;IECuNFA{KM7:TR?= NYLjbZZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlIxPDBpPkKyNlIzODRyPD;hQi=>
SH-SY5Y MnqzR5l1d3SxeHnjbZR6KGG|c3H5 MViyOEB1dyB2ODDo MnfzTWM2OCB;IECuNFA1KM7:TR?= NYnaWWx5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlIxPDBpPkKyNlIzODRyPD;hQi=>
HepG2 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NVqzb45iOjRidH:gOFghcA>? M36wUGlEPTBiPTCwMlAxPyEQvF2= Ml2wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkKwOFAoRjJ{MkKyNFQxRC:jPh?=
H460 M{i3[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUfHVYwzOjRidH:gOFghcA>? NY\XNpVnUUN3MDC9JFAvODB6IN88US=> NI\CR4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNlA1OCd-MkKyNlIxPDB:L3G+
HT-29 NWnl[Hc4S3m2b4TvfIlkcXS7IHHzd4F6 MlK2N{Bl[Xm| NWDuVWw2UUN3MDC9JFAvODB4IN88US=> MnvXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{M{m2NFEoRjJ{MkO5OlAyRC:jPh?=
DU145 NYHhVXFmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NWTzRlh5PzJiaB?= MWTHTVUxKD1iMD6wNFM5PiEQvF2= NVfydI1QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlU3QDVpPkKyNlY2Pjh3PD;hQi=>
KB MnPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M{m4[FczKGh? NEK2dFhIUTVyIE2gNE4xODRzMjFOwG0> NYOyR|NrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyOlU3QDVpPkKyNlY2Pjh3PD;hQi=>
A549 MkHtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NU\rNGNLPzJiaB?= MX7HTVUxKD1iMD6wNFU1PiEQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ4NU[4OUc,OjJ{NkW2PFU9N2F-
MCF7 M1jHNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXXBelMyQTZiaB?= NGP0WIFKSzVyIE2gNE4yKM7:TR?= M4KwcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{[wOlE{Lz5{MkO2NFYyOzxxYU6=
A549 NX\3NYlxS3m2b4TvfIlkcXS7IHHzd4F6 M{nFUVczKGh? NXHmU2kyUUN3MDC9JFAvOTlizszN NY\l[Fc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0O|IxPDNpPkKyOFczODR|PD;hQi=>
MCF7 M3zOVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MUK0PEBp M1PxNmlEPTBiPTCwMlAxPiEQvF2= M1rWTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEeyNFQ2Lz5{MkS3NlA1PTxxYU6=
K562 MV\DfZRwfG:6aXPpeJkh[XO|YYm= M4G4bVczKGh? NITtXJhKSzVyIE2gNE41OSEQvF2= M{TENFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEizNFkxLz5{MkS4N|A6ODxxYU6=
CaEs17 NEjqTFlEgXSxdH;4bYNqfHliYYPzZZk> NXfLepp7PzJiaB?= NXj2eIZxUUN3MDC9JFAvPDNizszN NYTu[JZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFMxQTBpPkKyOFg{ODlyPD;hQi=>
MGC803 M{XLfWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXfaVpMzPzJiaB?= M2HOUWlEPTBiPTCwMlg2KM7:TR?= Mlm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OEOwPVAoRjJ{NEizNFkxRC:jPh?=
HeLa MXrDfZRwfG:6aXPpeJkh[XO|YYm= NXi0Tm1IPzJiaB?= M{XHbWlEPTBiPTCwMlg6KM7:TR?= NHzpSpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|A6OCd-MkK0PFMxQTB:L3G+
Bel7402 NV7oSIRrS3m2b4TvfIlkcXS7IHHzd4F6 NG\hRpQ4OiCq MmfrTWM2OCB;IEGuPFkh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6M{C5NEc,OjJ2OEOwPVA9N2F-
A549 M4WxeGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4rkPVczKGh? MmSzTWM2OCB;IEOuOFYh|ryP NY\adWxyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFMxQTBpPkKyOFg{ODlyPD;hQi=>
MCF7 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NUL0TXlTPzJiaB?= MVLJR|UxKD1iND63O{DPxE1? M2nUbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEizNFkxLz5{MkS4N|A6ODxxYU6=
SKOV3 NUPseoxvS3m2b4TvfIlkcXS7IHHzd4F6 MW\JR|UxKD1iMD6wNFAyKM7:TR?= M1jkVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUC2OlIxLz5{MkWwOlYzODxxYU6=
BGC823 NULmOHIyS3m2b4TvfIlkcXS7IHHzd4F6 NXnH[mptUUN3MDC9JFAvODB|MzFOwG0> NYrS[|E6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NFY3OjBpPkKyOVA3PjJyPD;hQi=>
HepG2 Ml7lR5l1d3SxeHnjbZR6KGG|c3H5 NEmy[VBKSzVyIE2gNE4xODR2IN88US=> M2GwNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUC2OlIxLz5{MkWwOlYzODxxYU6=
A549 NFzUNHlEgXSxdH;4bYNqfHliYYPzZZk> MWXJR|UxKD1iMD6wNVYh|ryP MnHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3ME[2NlAoRjJ{NUC2OlIxRC:jPh?=
HCT8 M17mcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIm3PXRKSzVyIE2gNE4xPTFizszN MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVyNk[yNEc,OjJ3ME[2NlA9N2F-
CCRF-CEM MXrDfZRwfG:6aXPpeJkh[XO|YYm= NIW1WHA4OiCq NXPqXnNTUUN3MDC9JFAvODBzMjFOwG0> M3LROVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUC3PFk{Lz5{MkWwO|g6OzxxYU6=
taxol-resistant CCRF-CEM NYLhVHpZS3m2b4TvfIlkcXS7IHHzd4F6 NXfFWXJUPzJiaB?= NYLIclNqUUN3MDC9JFAvPDNizszN MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVyN{i5N{c,OjJ3MEe4PVM9N2F-
vinblastine-resistant CCRF-CEM M2XtT2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4D0WFczKGh? NFzidIpKSzVyIE2gNU4zPyEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVyN{i5N{c,OjJ3MEe4PVM9N2F-
BGC823 M4fCR2N6fG:2b4jpZ4l1gSCjc4PhfS=> MYi3NkBp NVmwbI9nUUN3MDC9JFAvODBzIN88US=> NF\RTZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4N|A4QSd-MkK1PFMxPzl:L3G+
A2780 NGHPbY9EgXSxdH;4bYNqfHliYYPzZZk> M4r2U|czKGh? MWrJR|UxKD1iMD6wNFEh|ryP M4jqblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUizNFc6Lz5{MkW4N|A4QTxxYU6=
Bel7402 MkPZR5l1d3SxeHnjbZR6KGG|c3H5 MlnRO|IhcA>? M4DBUGlEPTBiPTCwMlAxPiEQvF2= NGLmWpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4N|A4QSd-MkK1PFMxPzl:L3G+
A549 NHPCRYVEgXSxdH;4bYNqfHliYYPzZZk> MnLtO|IhcA>? Ml3MTWM2OCB;IECuNFE3KM7:TR?= NFLudpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4N|A4QSd-MkK1PFMxPzl:L3G+
HCT8 NHeyNnBEgXSxdH;4bYNqfHliYYPzZZk> MV[3NkBp MX7JR|UxKD1iMD6wOVEh|ryP MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV6M{C3PUc,OjJ3OEOwO|k9N2F-
MES-SA Ml;hR5l1d3SxeHnjbZR6KGG|c3H5 M{jRXlk3KGh? MkLTTWM2OCB;IECuNFA1KM7:TR?= NWTyOHBwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1PFc2OTlpPkKyOVg4PTF7PD;hQi=>
MESSA/DX5 M1LnVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NH7wWIg6PiCq M1jXTWlEPTBiPTCwMlc2KM7:TR?= NEH4Npg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4O|UyQSd-MkK1PFc2OTl:L3G+
HCT116 NW\NUohuS3m2b4TvfIlkcXS7IHHzd4F6 M3;sSGlEPTBiPTCwMlA2KM7:TR?= M1fFRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkmxNVc6Lz5{Mk[5NVE4QTxxYU6=
SKBR3 NV7aeItJS3m2b4TvfIlkcXS7IHHzd4F6 NITDeFVKSzVyIE2gNE4yOSEQvF2= NE\CU3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[5NVE4QSd-MkK2PVEyPzl:L3G+
SK-MEL-5 Mn3SR5l1d3SxeHnjbZR6KGG|c3H5 NYfV[5cyUUN3MDC9JFAvOTVizszN NH7NVYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[5NVE4QSd-MkK2PVEyPzl:L3G+
SKOV3 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NILad4NKSzVyIE2gNE41KM7:TR?= M2jEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkmxNVc6Lz5{Mk[5NVE4QTxxYU6=
MCF7 NVj4No1JS3m2b4TvfIlkcXS7IHHzd4F6 NY\uNWNvUUN3MDC9JFAvQSEQvF2= M2njV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkmxNVc6Lz5{Mk[5NVE4QTxxYU6=
PC3 M4PHWWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGfGXoo1QCCq MV\JR|UxKD1iMD6wNFA1KM7:TR?= NXniOHJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3PFM6PTRpPkKyO|g{QTV2PD;hQi=>
paclitaxel-resistant PC3-TxR Mm\PRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3XPV|Q5KGh? MXTJR|UxKD1iMD6xPFgh|ryP NELSRXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke4N|k2PCd-MkK3PFM6PTR:L3G+
MCF7 M4\wUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXOyOEBp NXXpOIlQUUN3MDC9JFAvODF3IN88US=> NFjDSmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkixPFA5OSd-MkK4NVgxQDF:L3G+
SKBR3 M4q0VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGTZNG81QCCq MXrJR|UxKD1iMD6wNFE6KM7:TR?= MkDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NUCyNVQoRjJ{OEWwNlE1RC:jPh?=
HepG2 NXzERmhpS3m2b4TvfIlkcXS7IHHzd4F6 M3rJNlczKGh? MVvJR|UxKD1iMD6wNFA1PCEQvF2= NIXvR4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki3NVIyPyd-MkK4O|EzOTd:L3G+
MCF7 NYTFbVZXS3m2b4TvfIlkcXS7IHHzd4F6 NGrlRWU4OiCq MXTJR|UxKD1iMD6wNFMh|ryP M{fXXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEexNlE4Lz5{Mki3NVIyPzxxYU6=
A375 M4HUcmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFzvSIQ4OiCq M1XRW2lEPTBiPTCwMlAxQTJizszN NUHh[FZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4O|EzOTdpPkKyPFcyOjF5PD;hQi=>
BxPC3 MnPYR5l1d3SxeHnjbZR6KGG|c3H5 MnfKO|IhcA>? NG\4UmVKSzVyIE2gNE4xQSEQvF2= NVq4cI82RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4O|EzOTdpPkKyPFcyOjF5PD;hQi=>
SMMC7721 NVzydIxmS3m2b4TvfIlkcXS7IHHzd4F6 MWG3NkBp MWPJR|UxKD1iMD6xOUDPxE1? Mn\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6N{GyNVcoRjJ{OEexNlE4RC:jPh?=
PANC1 NHzNPIREgXSxdH;4bYNqfHliYYPzZZk> MWC3NkBp NF7HVZNKSzVyIE2gNE4zPiEQvF2= NX;ufWF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4O|EzOTdpPkKyPFcyOjF5PD;hQi=>
A549 NVzNenJyS3m2b4TvfIlkcXS7IHHzd4F6 NYXFZndwPzJiaB?= NYi5WHd2UUN3MDC9JFAvPzJizszN M3vpfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEexNlE4Lz5{Mki3NVIyPzxxYU6=
AGS MkGxR5l1d3SxeHnjbZR6KGG|c3H5 MoT6O|IhcA>? MmXGTWM2OCB;IEGuOkDPxE1? M37TUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEexNlE4Lz5{Mki3NVIyPzxxYU6=
NCI-H2126 NUXnPWF5S3m2b4TvfIlkcXS7IHHzd4F6 M4D4TlczKGh? NVHBeVZuUUN3MDC9JFIvPSEQvF2= NILnV5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki3NVIyPyd-MkK4O|EzOTd:L3G+
MDA-MB-231 NXi1S5JjS3m2b4TvfIlkcXS7IHHzd4F6 Mmn3O|IhcA>? NEPXOpJKSzVyIE2gOUDPxE1? NEDHXpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki3NVIyPyd-MkK4O|EzOTd:L3G+
U87 M3GzcWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4LWVFczKGh? MkTiTWM2OCB;IEiuNUDPxE1? NH6wU4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki3NVIyPyd-MkK4O|EzOTd:L3G+
HELF NVrEVHZZS3m2b4TvfIlkcXS7IHHzd4F6 MkK5NlQhcA>? MoLCTWM2OCB;IEeuNVQh|ryP NUfOZpBPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NFE1OTBpPkKyPVAyPDFyPD;hQi=>
BGC NYLJPGJFS3m2b4TvfIlkcXS7IHHzd4F6 M3TqbVI1KGh? M1zidWlEPTBiPTC5MlI3KM7:TR?= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjlyMUSxNEc,OjJ7MEG0NVA9N2F-
HELF MljTR5l1d3SxeHnjbZR6KGG|c3H5 NWnQXIxnOjRiaB?= MVrJR|UxKD1iNz6xOEDPxE1? NGTEcoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyNVk3Pid-MkK5NlE6PjZ:L3G+
BGC MX7DfZRwfG:6aXPpeJkh[XO|YYm= MlfmNlQhcA>? M{jofWlEPTBiPTC5MlI3KM7:TR?= NFTCfmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyNVk3Pid-MkK5NlE6PjZ:L3G+
DU145 NYfHTmZoS3m2b4TvfIlkcXS7IHHzd4F6 NInHeJU4OiCq NIXyPIVIUTVyIE2gNE4xODJ3NTFOwG0> MnWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{KzNVMoRjJ{OUOyN|E{RC:jPh?=
KB NEXY[ZNEgXSxdH;4bYNqfHliYYPzZZk> MYq3NkBp Mn3nS2k2OCB;IECuNFAzPjVizszN MmfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{KzNVMoRjJ{OUOyN|E{RC:jPh?=
A549 MlrwR5l1d3SxeHnjbZR6KGG|c3H5 NIrzUm44OiCq NIDTVWpIUTVyIE2gNE4xODR6OTFOwG0> Mom2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{KzNVMoRjJ{OUOyN|E{RC:jPh?=
KBVIN NUHDb2NmS3m2b4TvfIlkcXS7IHHzd4F6 MmroO|IhcA>? NFS2RoZIUTVyIE2gNE46PDhizszN MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|MkOxN{c,OjJ7M{KzNVM9N2F-
HL60 M16x[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MUm3NkBp M33QdWlEPTBiPTCwMlAxOjh{IN88US=> M1nme|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUW5OVE5Lz5{Mkm1PVUyQDxxYU6=
HeLa MnP5R5l1d3SxeHnjbZR6KGG|c3H5 M1LLfFczKGh? M2Hr[mlEPTBiPTCwMlAxOjl|IN88US=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl3OUWxPEc,OjJ7NUm1NVg9N2F-
U937 MmHTR5l1d3SxeHnjbZR6KGG|c3H5 NG\RfoY4OiCq MV;JR|UxKD1iMD6wNFM{PyEQvF2= NWGwNopnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5OVk2OThpPkKyPVU6PTF6PD;hQi=>
HeLa NFLaTGtEgXSxdH;4bYNqfHliYYPzZZk> NXztOZhwUUN3MDC9JFEh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzFyM{C5O{c,OjNzMEOwPVc9N2F-
A2780 M3SwXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWnZRXVkUUN3MDC9JFEvOSEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzFyM{C5O{c,OjNzMEOwPVc9N2F-
A549 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmraO|IhcA>? NXHrOFJlUUN3MDC9JFAvODB5MjFOwG0> MlrTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzMUexO|EoRjJ|MUG3NVcyRC:jPh?=
taxol-resistant A549-T12 MnvqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NGLNcI04OiCq NFThNmJKSzVyIE2gNE4xPzV{IN88US=> M4TLWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUG3NVcyLz5{M{GxO|E4OTxxYU6=
IGROV1/Pt1 M1fDd2N6fG:2b4jpZ4l1gSCjc4PhfS=> NUjtcmJZPzJiaB?= NH\YcVNKSzVyIE2gNE4xODJ{IN88US=> MljtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNECzOVgoRjJ|MUSwN|U5RC:jPh?=
SKOV3 MkPuR5l1d3SxeHnjbZR6KGG|c3H5 NYDYWJg2PzJiaB?= MlvtTWM2OCB;IECuNFAzPyEQvF2= MojEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNECzOVgoRjJ|MUSwN|U5RC:jPh?=
U2OS MX;DfZRwfG:6aXPpeJkh[XO|YYm= MWq3NkBp NUSz[ZJ4UUN3MDC9JFAvODB|NDFOwG0> M{Tub|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUSwN|U5Lz5{M{G0NFM2QDxxYU6=
PANC1 Ml3hR5l1d3SxeHnjbZR6KGG|c3H5 NH;IfJY4OiCq NGi2[o5KSzVyIE2gNE4xODV{IN88US=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2MEO1PEc,OjNzNECzOVg9N2F-
MIAPaCa2 NWPSTWVTS3m2b4TvfIlkcXS7IHHzd4F6 NGLVS244OiCq M{SzUGlEPTBiPTCwMlAxPzJizszN MoOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNECzOVgoRjJ|MUSwN|U5RC:jPh?=
IGROV1 NU\vS5d2S3m2b4TvfIlkcXS7IHHzd4F6 NYLKVZV6PzJiaB?= M4LUXWlEPTBiPTCwMlAzOyEQvF2= NYj3cZI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOFA{PThpPkKzNVQxOzV6PD;hQi=>
MES-SA NESzcFlEgXSxdH;4bYNqfHliYYPzZZk> MkTzTWM2OCB;IECuNFA{KM7:TR?= M{S3OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUSxPVE3Lz5{M{G0NVkyPjxxYU6=
A2780 MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MUKyJIRigXN? NWn1XFF1UUN3MDC9JFAvODJ6IN88US=> NIL2Npg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0PVMxPCd-MkOxOFk{ODR:L3G+
MDA-MB-231 MWXDfZRwfG:6aXPpeJkh[XO|YYm= MkjBO|IhcA>? MWjJR|UxKD1iMD6wOVIh|ryP NF;0e249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N|M6Pyd-MkOxOVM{QTd:L3G+
HepG2 NF7TWpFEgXSxdH;4bYNqfHliYYPzZZk> NGW1bpY4OiCq NFzKOm9KSzVyIE2gNE4xPTRizszN MkLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUOzPVcoRjJ|MUWzN|k4RC:jPh?=
A549 MoTOR5l1d3SxeHnjbZR6KGG|c3H5 MnzCO|IhcA>? Mn7uTWM2OCB;IECuNFU3KM7:TR?= MoL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNUOzPVcoRjJ|MUWzN|k4RC:jPh?=
NUGC3 NXHSc3hZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M13ncGdKPTBiPTCwMlAzKM7:TR?= NFjsWXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G2O|YyPCd-MkOxOlc3OTR:L3G+
HONE1 M1n0R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2GzXmdKPTBiPTCwMlAzKM7:TR?= NGXQSoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G2O|YyPCd-MkOxOlc3OTR:L3G+
NCI-H460 Mnv0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFSxS5lIUTVyIE2gNE4xOyEQvF2= M1PTb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MU[3OlE1Lz5{M{G2O|YyPDxxYU6=
MCF7 NFLXd5BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfadJhIUTVyIE2gNE4xOyEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF4N{[xOEc,OjNzNke2NVQ9N2F-
A549 Mn2yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1fLZ2dKPTBiPTCwMlA3KM7:TR?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF4N{[xOEc,OjNzNke2NVQ9N2F-
HepG2 NELB[HVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXnS2k2OCB;IECuNVgh|ryP NXz1[G5RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOlc3OTRpPkKzNVY4PjF2PD;hQi=>
HeLa M1u1NWN6fG:2b4jpZ4l1gSCjc4PhfS=> MojyPVYhcA>? MXTJR|UxKD1iMD6wNFEh|ryP Mnn3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzN{[2NlgoRjJ|MUe2OlI5RC:jPh?=
SW780 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NEO2N|E6PiCq MorrTWM2OCB;IECuNFAyOSEQvF2= M2\hPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUe2OlI5Lz5{M{G3OlYzQDxxYU6=
MESSA MljZR5l1d3SxeHnjbZR6KGG|c3H5 M1vsVFczKGh? NF\xeIFKSzVyIE2gNE4xODRizszN MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNES1Nkc,OjN{MUS0OVI9N2F-
OVCAR8 NHPOcolEgXSxdH;4bYNqfHliYYPzZZk> NYXZXZJ3UUN3MDC9JFAvODB3IN88US=> NH;CcnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KxOFQ2Oid-MkOyNVQ1PTJ:L3G+
HeLa M1vkPGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFTyfoc1QCCq M1rHfGlEPTBiPTCwMlAxPSEQvF2= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNES1Nkc,OjN{MUS0OVI9N2F-
A549 MmWxR5l1d3SxeHnjbZR6KGG|c3H5 MnHmOFghcA>? NUizPVRyUUN3MDC9JFAvODB5IN88US=> NYK0SmlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNVQ1PTJpPkKzNlE1PDV{PD;hQi=>
HT-29 MWjDfZRwfG:6aXPpeJkh[XO|YYm= NHzwc|Y1QCCq NF3FdFZKSzVyIE2gNE4xODhizszN MofjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{MUS0OVIoRjJ|MkG0OFUzRC:jPh?=
HCT15 NIXLUVlEgXSxdH;4bYNqfHliYYPzZZk> NHrxdmk4OiCq M{nrb2lEPTBiPTCwMlA6KM7:TR?= NYTMO2RlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNVQ1PTJpPkKzNlE1PDV{PD;hQi=>
MESSA/DX5 NI\FcIFEgXSxdH;4bYNqfHliYYPzZZk> MoHmO|IhcA>? MYDJR|UxKD1iMT63OlQh|ryP MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNES1Nkc,OjN{MUS0OVI9N2F-
NCI/ADR-RES MVfDfZRwfG:6aXPpeJkh[XO|YYm= MVfJR|UxKD1iMz6zJO69VQ>? MlGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{MUS0OVIoRjJ|MkG0OFUzRC:jPh?=
DU145 MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV\HTVUxKD1iMD6wNFY2KM7:TR?= Mn3sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{N{SxNlMoRjJ|Mke0NVI{RC:jPh?=
KB MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{fxe2dKPTBiPTCwMlAxPzd5IN88US=> M1XRflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mke0NVI{Lz5{M{K3OFEzOzxxYU6=
A549 M1LXVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LSZ2dKPTBiPTCwMlAxQDF6IN88US=> MmrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{N{SxNlMoRjJ|Mke0NVI{RC:jPh?=
KBVIN M1v0OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGnpTZNIUTVyIE2gNU45ODNizszN NV32NoRsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyO|QyOjNpPkKzNlc1OTJ|PD;hQi=>
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2008 NGLRVXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoPMS2k2OCB;IECuNFA{KM7:TR?= NUDWcIRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3OVA1PTVpPkKzO|UxPDV3PD;hQi=>
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A549 MY\DfZRwfG:6aXPpeJkh[XO|YYm= NIrwdXpKSzVyIE2gNE4xODN4IN88US=> NIi2eGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwOlEyOid-MkO4NFYyOTJ:L3G+
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rat lymphatic endothelial NITQ[ZdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{D1dVQ5KGh? M1\NUWlEPTBiPTCwMlAyQCEQvF2= M13yVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEW1N|M5Lz5{M{i1OVM{QDxxYU6=
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SKOV3/M6-6 isogenic MVPGeY5kfGmxbjDhd5NigQ>? NH\Cd3o1QCCq MlG3TWM2OCB;IEKuOkDPxE1? M4LB[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEm1OVMzLz5{M{i5OVU{OjxxYU6=
MES-SA MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVy0PEBp NWnpbIRnT0l3MDC9JFAvODB5IN88US=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl{N{e5N{c,OjN7Mke3PVM9N2F-
MES-SA/Dx5 NH3SXXBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPzeG9JPDhiaB?= NVuwTXpYT0l3MDC9JFkvQCEQvF2= NUe3[45qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5Nlc4QTNpPkKzPVI4Pzl|PD;hQi=>
HL60 Ml\IR5l1d3SxeHnjbZR6KGG|c3H5 M4rWdWlEPTBiPTCwMlAxOiEQvF2= NV\vUo5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N|c6QDFpPkKzPVM4QThzPD;hQi=>
DU145 MlzPR5l1d3SxeHnjbZR6KGG|c3H5 Ml61TWM2OCB;IECuNFA2KM7:TR?= NGLHb2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzO|k5OSd-MkO5N|c6QDF:L3G+
MES-SA NFPkZ|dEgXSxdH;4bYNqfHliYYPzZZk> MmLGTWM2OCB;IECuNFA2KM7:TR?= MofrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{e5PFEoRjJ|OUO3PVgyRC:jPh?=
MDA435 M{nz[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NWfmVlJCUUN3MDC9JFAvODB3IN88US=> NEnT[lQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzO|k5OSd-MkO5N|c6QDF:L3G+
Bowes MonuR5l1d3SxeHnjbZR6KGG|c3H5 MVrJR|UxKD1iMD6wNFUh|ryP MlTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{e5PFEoRjJ|OUO3PVgyRC:jPh?=
A549 NFrIUlNEgXSxdH;4bYNqfHliYYPzZZk> MV3JR|UxKD1iMD6wNUDPxE1? NFi4c5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzO|k5OSd-MkO5N|c6QDF:L3G+
Clone A MoHFR5l1d3SxeHnjbZR6KGG|c3H5 MofKTWM2OCB;IECuOUDPxE1? NV7WfpVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N|c6QDFpPkKzPVM4QThzPD;hQi=>
MIP101 Mn3aR5l1d3SxeHnjbZR6KGG|c3H5 NGDmXWdKSzVyIE2gNU4yKM7:TR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl|N{m4NUc,OjN7M{e5PFE9N2F-
PBMC MV;DfZRwfG:6aXPpeJkh[XO|YYm= MkKzTWM2OCB;IEWg{txO NU\meZBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N|c6QDFpPkKzPVM4QThzPD;hQi=>
39SK M2rrVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYDJR|UxKD1iNTFOwG0> NIWxSGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzO|k5OSd-MkO5N|c6QDF:L3G+
HL60 NHniN3dCdnSrbXnjdo9jcWGuIHHzd4F6 M{TxS|Q5KGh? MVrJR|UxKD1iMD6wNFgh|ryP NYjRfHprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OVc1PTNpPkKzPVU4PDV|PD;hQi=>
SMMC7721 NFjOO5NCdnSrbXnjdo9jcWGuIHHzd4F6 NGnpPWs1QCCq NUW3cJdJUUN3MDC9JFAvODB6IN88US=> NUjVbHdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OVc1PTNpPkKzPVU4PDV|PD;hQi=>
MCF7 MoHwRY51cW2rY4LvZolidCCjc4PhfS=> NXz6SGdqPDhiaB?= NEDsNYVKSzVyIE2gNE4xODhizszN MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl3N{S1N{c,OjN7NUe0OVM9N2F-
SW480 NVPEWnBzSW62aX3pZ5Jw[mmjbDDhd5NigQ>? MofKOFghcA>? NEXrbo9KSzVyIE2gNE4xPCEQvF2= NUiyUWx3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5OVc1PTNpPkKzPVU4PDV|PD;hQi=>
A549 MkTlRY51cW2rY4LvZolidCCjc4PhfS=> MYG0PEBp NYXGVlgzUUN3MDC9JFAvOSEQvF2= M331OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUW3OFU{Lz5{M{m1O|Q2OzxxYU6=
MCF7 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NUfVcmlYPzJiaB?= NUPBWXZvUUN3MDC9JFAvODB|IN88US=> M2PWZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEGyN|c5Lz5{NECxNlM4QDxxYU6=
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DU145 MVnDfZRwfG:6aXPpeJkh[XO|YYm= NXfrUIdtPzJiaB?= M1TUeGlEPTBiPTCwMlA1KM7:TR?= MnjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyM{OxN|EoRjJ2MEOzNVMyRC:jPh?=
WI38 NXLXPFRNS3m2b4TvfIlkcXS7IHHzd4F6 MXO3NkBp MWHJR|UxKD1iMD6wOUDPxE1? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB|M{GzNUc,OjRyM{OxN|E9N2F-
MCF7 MUXDfZRwfG:6aXPpeJkh[XO|YYm= MXO0PEBp MVvJR|UxKD1iMD61JO69VQ>? NGHv[|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC1OlE1Pid-MkSwOVYyPDZ:L3G+
PC3 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MmHyOFghcA>? NHftWItKSzVyIE2gNU42KM7:TR?= M2DW[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEW2NVQ3Lz5{NEC1OlE1PjxxYU6=
A549 MUfDfZRwfG:6aXPpeJkh[XO|YYm= NHfSbWM4OiCq NIPPcFdKSzVyIE2gNE4xOiEQvF2= MlS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNkO1OlcoRjJ2ME[zOVY4RC:jPh?=
NB4 NEjsVYREgXSxdH;4bYNqfHliYYPzZZk> M3nPc|czKGh? MWHJR|UxKD1iMD6wN{DPxE1? Mo\EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNkO1OlcoRjJ2ME[zOVY4RC:jPh?=
MCF7 MonBR5l1d3SxeHnjbZR6KGG|c3H5 NFL3[nk4OiCq NHXSZXJKSzVyIE2gNE4yKM7:TR?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB4M{W2O{c,OjRyNkO1Olc9N2F-
SH-SY5Y NFvzPFBEgXSxdH;4bYNqfHliYYPzZZk> NGPQZoM4OiCq NHn1O3ZKSzVyIE2gNE4zKM7:TR?= MkC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNkO1OlcoRjJ2ME[zOVY4RC:jPh?=
PC3 NYW4V5RpS3m2b4TvfIlkcXS7IHHzd4F6 NXLjNId5PzJiaB?= M3nvUGlEPTBiPTCwMlIh|ryP Mln1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNkO1OlcoRjJ2ME[zOVY4RC:jPh?=
A549 Ml\2R5l1d3SxeHnjbZR6KGG|c3H5 NXPlTZdnPDhiaB?= Mn3PTWM2OCB;IECuNFIh|ryP MmTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyNkO1PFIoRjJ2ME[zOVgzRC:jPh?=
NB4 NE\rUlBEgXSxdH;4bYNqfHliYYPzZZk> M4fPVVQ5KGh? NFvWcFhKSzVyIE2gNE4xOyEQvF2= NE\ofY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC2N|U5Oid-MkSwOlM2QDJ:L3G+
MCF7 M160OmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3KyOFQ5KGh? NVi4XVVKUUN3MDC9JFAvOSEQvF2= NGDKTnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC2N|U5Oid-MkSwOlM2QDJ:L3G+
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SH-SY5Y MXrDfZRwfG:6aXPpeJkh[XO|YYm= MW[0PEBp MUnJR|UxKD1iMD6yJO69VQ>? NIf6fWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC2N|U5Oid-MkSwOlM2QDJ:L3G+
HeLa NXL0RnhrS3m2b4TvfIlkcXS7IHHzd4F6 MlPiO|IhcA>? MVPJR|UxKD1iMD6wNFE1KM7:TR?= MlznQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOEe4OVcoRjJ2MEi3PFU4RC:jPh?=
SKOV3 NV7UcGJKS3m2b4TvfIlkcXS7IHHzd4F6 MX63NkBp Ml7jTWM2OCB;IECuNFA{KM7:TR?= NF\BRm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC4O|g2Pyd-MkSwPFc5PTd:L3G+
KB NE\kPGZEgXSxdH;4bYNqfHliYYPzZZk> NV7pc|l5PzJiaB?= NF71dFVKSzVyIE2gNE4xODRzIN88US=> NWP4eYFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxNFY6QDJpPkK0NVA3QTh{PD;hQi=>
KB-7d MoO3R5l1d3SxeHnjbZR6KGG|c3H5 MVO3NkBp Mni1TWM2OCB;IECuNFA4QSEQvF2= M4LIXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUC2PVgzLz5{NEGwOlk5OjxxYU6=
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MCF7 M1fn[mN6fG:2b4jpZ4l1gSCjc4PhfS=> NIeyNlRKSzVyIE2gN{4yKM7:TR?= NUTPPZBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxPVU1PjZpPkK0NVk2PDZ4PD;hQi=>
A549 NUTPWllCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NFPYVZI6PiCq NYLLOnZqUUN3MDC9JFAvODB2NDFOwG0> MmLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MUG2N|koRjJ2MkGxOlM6RC:jPh?=
MCF7 NHrFeZBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MoPqPVYhcA>? NH7vemlKSzVyIE2gNE4xOjB3IN88US=> M325[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkGxOlM6Lz5{NEKxNVY{QTxxYU6=
HL60 M1vocmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4LPU|Q5KGh? MoXCTWM2OCB;IECuNFA5KM7:TR?= NV:4NHRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVk5ODlpPkK0NlE6QDB7PD;hQi=>
SW480 MlP3R5l1d3SxeHnjbZR6KGG|c3H5 NVy1OlJnPDhiaB?= M4rKNmlEPTBiPTCwMlAxQCEQvF2= M{KyN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkG5PFA6Lz5{NEKxPVgxQTxxYU6=
A549 M{HobWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3fFUVQ5KGh? MUjJR|UxKD1iMD6wNFgh|ryP NYHPNmZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVk5ODlpPkK0NlE6QDB7PD;hQi=>
MCF7 M{fFeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX\l[Y5QPDhiaB?= M1PTc2lEPTBiPTCwMlAxQCEQvF2= M3rpdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkG5PFA6Lz5{NEKxPVgxQTxxYU6=
SMMC7721 M1vSUGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1;Wd|Q5KGh? M2XTW2lEPTBiPTCwMlAxQCEQvF2= NIL4TWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKxPVgxQSd-MkSyNVk5ODl:L3G+
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UACC62 NFe1WFZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYiwXHJ5PDhiaB?= M33WfmdKPTBiPTCwMlAyKM7:TR?= M4jBdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{K3OFY1Lz5{NEeyO|Q3PDxxYU6=
786-0 MmnaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkftOFghcA>? M1LYeWdKPTBiPTCwMlAzKM7:TR?= NWXzVoFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3Nlc1PjRpPkK0O|I4PDZ2PD;hQi=>
African green monkey Vero NYnXWJRbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGrRZYo1QCCq NF\KXo9IUTVyIE2gNE4xOyEQvF2= Mom0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Mke0OlQoRjJ2N{K3OFY1RC:jPh?=
NCI-ADR-RES MkfWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NELIOWk1QCCq NVjQZ2pzT0l3MDC9JFAvODRizszN MkPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Mke0OlQoRjJ2N{K3OFY1RC:jPh?=
NCI-H460 NVyx[lZYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1n1NlQ5KGh? NHXF[m1IUTVyIE2gNE4yKM7:TR?= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd{N{S2OEc,OjR5Mke0OlQ9N2F-
PC3 M334UGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH2ySnc1QCCq NET6OYdIUTVyIE2gNE4yKM7:TR?= NFS0fZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEeyO|Q3PCd-MkS3Nlc1PjR:L3G+
K562 M2HEO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHHkfFQ1QCCq NIjxS5JIUTVyIE2gNE4yKM7:TR?= NXrtNZdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3Nlc1PjRpPkK0O|I4PDZ2PD;hQi=>
OVCAR3 NITkfppIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnrlOFghcA>? Mni3S2k2OCB;IECuNkDPxE1? M1S5UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{K3OFY1Lz5{NEeyO|Q3PDxxYU6=
HepG2 NEHYbmlEgXSxdH;4bYNqfHliYYPzZZk> MmHZN{Bl[Xm| MkTjTWM2OCB;IECuNFAxOTlizszN MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd2NUm2PEc,OjR5NEW5Olg9N2F-
KB NH[zd2dEgXSxdH;4bYNqfHliYYPzZZk> M3n3OlMh\GG7cx?= NYHrR2t3UUN3MDC9JFAvODB|OTFOwG0> NFnZdG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0OVk3QCd-MkS3OFU6Pjh:L3G+
NCI-ADR-RES NFjDSpREgXSxdH;4bYNqfHliYYPzZZk> NHHwPW5GSzVyIE2gNE4xOTNizszN NV\2O|I1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NFE3OTBpPkK0PFAyPjFyPD;hQi=>
OVCAR8 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MVLFR|UxKD1iMD6wNVgh|ryP NVftSoZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NFE3OTBpPkK0PFAyPjFyPD;hQi=>
NALM6 Ml7URY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYC0PEB1dyB5MjDo MU\JR|UxKD1iMD6wNFQyKM7:TR?= MonKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6NUKyPFEoRjJ2OEWyNlgyRC:jPh?=
Jurkat MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Moi4OFghfG9iN{KgbC=> M2D2PWlEPTBiPTCwMlAxPDVizszN NEHYepY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi1NlI5OSd-MkS4OVIzQDF:L3G+
K562 NYftOIdlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIH2cpM1QCC2bzC3NkBp MlvLTWM2OCB;IECuNFA2PSEQvF2= NITIbmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi1NlI5OSd-MkS4OVIzQDF:L3G+
HeLa MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYPhUGVqUUN3MDC9JFAvODBzMkGg{txO NHSxe4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MDA-MB-435 MmfnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MnjHTWM2OCB;IECuNFAyQTNizszN M1LXXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
SKOV3 NYTx[G9iSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M2H1eWlEPTBiPTCwMlAxOyEQvF2= M{\rV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmwOlUzLz5{NEi5NFY2OjxxYU6=
SKOV3 M4HsbGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXvHTVUxKD1iMD6wNFQ4KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7M{KyOEc,OjR6OUOyNlQ9N2F-
P-gp expressing SKOV3-M6/6 M2D5XWN6fG:2b4jpZ4l1gSCjc4PhfS=> NI\QfnJIUTVyIE2gNE43KM7:TR?= NFfRO4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5N|IzPCd-MkS4PVMzOjR:L3G+
PC3 MWjDfZRwfG:6aXPpeJkh[XO|YYm= NFjkcos6PiCq NVXZS4E1UUN3MDC9JFAvODB{NTFOwG0> NGn4ZoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFQ{Pyd-MkS5NFA1Ozd:L3G+
HeLa M3zMZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2rJcVk3KGh? NXHwZYs4UUN3MDC9JFAvODB3MzFOwG0> MlP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC4OlUoRjJ2OUCwPFY2RC:jPh?=
OVCAR8 MlX3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFf2TGs6PiCq NGj2b3RKSzVyIE2gNE4xOSEQvF2= NXjreJRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA5PjVpPkK0PVAxQDZ3PD;hQi=>
NCI/ADR-RES M3nM[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHTJOZA6PiCq MVLJR|UxKD1iNTFOwG0> MkCwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MEC4OlUoRjJ2OUCwPFY2RC:jPh?=
MCF7 NXnidXE4S3m2b4TvfIlkcXS7IHHzd4F6 NWDjfIR3PzJiaB?= MUjJR|UxKD1iMD6wOFUh|ryP MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{OUO0OEc,OjR7MkmzOFQ9N2F-
HCT116 NV3hbJc2S3m2b4TvfIlkcXS7IHHzd4F6 MkDyO|IhcA>? NHfYZWxKSzVyIE2gNE4xPjlizszN MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{OUO0OEc,OjR7MkmzOFQ9N2F-
HepG2 MmiyR5l1d3SxeHnjbZR6KGG|c3H5 MlnFO|IhcA>? M3zEUWlEPTBiPTCwMlA5PCEQvF2= M3HZXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUK5N|Q1Lz5{NEmyPVM1PDxxYU6=
HeLa NXT3b3Q3S3m2b4TvfIlkcXS7IHHzd4F6 NV;oUmVIPzJiaB?= MXfJR|UxKD1iMD6wPVYh|ryP M1:wdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUK5N|Q1Lz5{NEmyPVM1PDxxYU6=
U251 MXzDfZRwfG:6aXPpeJkh[XO|YYm= NHL0VlU4OiCq MkjaTWM2OCB;IECuNVI5KM7:TR?= M2jZc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUK5N|Q1Lz5{NEmyPVM1PDxxYU6=
HT-29 NEf2N|lEgXSxdH;4bYNqfHliYYPzZZk> MVvJR|UxKD1iMD6wNFEh|ryP NUnBbJZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5N|czODlpPkK0PVM4OjB7PD;hQi=>
HT-29 M1K5SGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MViyOEBidmRiN{KgbC=> M3jzWWlEPTBiPTCwMlI6KM7:TR?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2MUGzNEc,OjR7NEGxN|A9N2F-
HeLa M3nhdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWXaXFJsOjRiYX7kJFczKGh? MXLJR|UxKD1iMD6yPUDPxE1? NGHMXHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm0NVE{OCd-MkS5OFEyOzB:L3G+
Caco2 M37LOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlL4NlQh[W6mIEeyJIg> MkW4TWM2OCB;IECuN|Eh|ryP M2rqNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUSxNVMxLz5{NEm0NVE{ODxxYU6=
HL60 Ml7rRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NEDTUYozPCCjbnSgO|IhcA>? MWTJR|UxKD1iMD6zNkDPxE1? M3ewO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUSxNVMxLz5{NEm0NVE{ODxxYU6=
MCF7 MnztRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M3j5WlI1KGGwZDC3NkBp M{\YdmlEPTBiPTCwMlM{KM7:TR?= NUPNe4FZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OFEyOzBpPkK0PVQyOTNyPD;hQi=>
Saos2 M2LqUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmLGNlQh[W6mIEeyJIg> NInF[49KSzVyIE2gNE4{PSEQvF2= M3\SdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUSxNVMxLz5{NEm0NVE{ODxxYU6=
SKOV3-MDR1-M6/6 MoPJRY51cWOjbnPldkBie3OjeR?= MmT5OFghcA>? MVjJR|UxKD1iMD65O{DPxE1? NEHqeIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm0OlE1PSd-MkS5OFYyPDV:L3G+
SKOV3 NHLnbotCdnSrY3HuZ4VzKGG|c3H5 NVHoeHV{PDhiaB?= MWXJR|UxKD1iMTFOwG0> MnLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NE[xOFUoRjJ2OUS2NVQ2RC:jPh?=
MDA435/LCC6 MVzDfZRwfG:6aXPpeJkh[XO|YYm= MU[1JIRigXN? NUjDOGl7UUN3MDC9JFAvODB{NjFOwG0> Ml[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NUKzO|YoRjJ2OUWyN|c3RC:jPh?=
MDA435/LCC6MDR M1[0SWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVXGZ5NlPSCmYYnz MmP4TWM2OCB;IECuNVQ6OyEQvF2= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl3MkO3Okc,OjR7NUKzO|Y9N2F-
MCF7 MWLDfZRwfG:6aXPpeJkh[XO|YYm= Ml\yTWM2OCB;IECuNFAyPSEQvF2= NWXrR5pLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OlAyPDNpPkK0PVYxOTR|PD;hQi=>
HepG2 MXnDfZRwfG:6aXPpeJkh[XO|YYm= NGXBc29KSzVyIE2gNE4xODR4IN88US=> NHfWNXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm2NFE1Oyd-MkS5OlAyPDN:L3G+
MDA-MB-231 MmLtR5l1d3SxeHnjbZR6KGG|c3H5 M4\LWGlEPTBiPTCwMlAxQDJizszN NVTQVYNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OlAyPDNpPkK0PVYxOTR|PD;hQi=>
HL7702 NGPWfHBEgXSxdH;4bYNqfHliYYPzZZk> M2Dt[2lEPTBiPTCxMlEh|ryP MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl4MEG0N{c,OjR7NkCxOFM9N2F-
MCF7 NGDZWHVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MljLOFghcA>? NF23e5NKSzVyIE2gNE4xOjV6MTFOwG0> NVXHfHRYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVYyOzZpPkK0PVk3OTN4PD;hQi=>
HepG2 MlfaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkD3OFghcA>? M3rBbmlEPTBiPTCwMlA3PzJ5IN88US=> MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7NkGzOkc,OjR7OU[xN|Y9N2F-
A549 M4Xo[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NETBcVE1QCCq MnTpTWM2OCB;IEGuOVI2KM7:TR?= NUCy[pdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5PVYyOzZpPkK0PVk3OTN4PD;hQi=>
KB M4X3e2N6fG:2b4jpZ4l1gSCjc4PhfS=> M4fUbFczKGh? MWrJR|UxKD1iMD6wNFM6KM7:TR?= M2TPfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEC4OFU3Lz5{NUCwPFQ2PjxxYU6=
A549 MXfDfZRwfG:6aXPpeJkh[XO|YYm= MYS3NkBp MWfJR|UxKD1iMD6wNFU4KM7:TR?= M{\EU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEC4OFU3Lz5{NUCwPFQ2PjxxYU6=
MDA-MB-231 NETwR21EgXSxdH;4bYNqfHliYYPzZZk> M{HBWVczKGh? MVLJR|UxKD1iMD6wNFY3KM7:TR?= NUDTZ2pJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNFg1PTZpPkK1NFA5PDV4PD;hQi=>
KBVIN MXnDfZRwfG:6aXPpeJkh[XO|YYm= MXm3NkBp NHnhUGdKSzVyIE2gNU41PCEQvF2= M{X5cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEC4OFU3Lz5{NUCwPFQ2PjxxYU6=
MESSA NV3MPG46S3m2b4TvfIlkcXS7IHHzd4F6 NEiyRYE4OiCq NEH0SppKSzVyIE2gNE4xODRizszN NFzYTFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCyOVk6OSd-MkWwNlU6QTF:L3G+
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A2780 M2rne2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXHz[IhZUUN3MDC9JFAvODByNDFOwG0> NELiXlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0O|k{QCd-MkWwOFc6Ozh:L3G+
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MCF7 NXu0Z2tYS3m2b4TvfIlkcXS7IHHzd4F6 M1fE[2lEPTBiPTCwMlAxOTdizszN NFrmXXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0O|k{QCd-MkWwOFc6Ozh:L3G+
1A9 M2CxcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWrJR|UxKD1iMD6wNFM6KM7:TR?= NHz4VFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0O|k{QCd-MkWwOFc6Ozh:L3G+
1A9/A8 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NULTbII5UUN3MDC9JFAvODB2MjFOwG0> NWDkVW1XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOFc6OzhpPkK1NFQ4QTN6PD;hQi=>
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1A9PTX10 MkfPR5l1d3SxeHnjbZR6KGG|c3H5 MnfXTWM2OCB;IECuNFgyPCEQvF2= NWfaXZBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOFc6OzhpPkK1NFQ4QTN6PD;hQi=>
MCF7/R NUXienZuS3m2b4TvfIlkcXS7IHHzd4F6 Mnv2TWM2OCB;IECuNlk6KM7:TR?= NFfjR2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC0O|k{QCd-MkWwOFc6Ozh:L3G+
A2780AD MYXDfZRwfG:6aXPpeJkh[XO|YYm= NGHDeoNKSzVyIE2gNU4zPDRizszN MkTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNEe5N|goRjJ3MES3PVM5RC:jPh?=
KB Ml[zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MnvkTWM2OCB;IECuNFA{OyEQvF2= NHzFWXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC1PVUxOyd-MkWwOVk2ODN:L3G+
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A549 MkPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MWO0PEBp NWHXXlg{UUN3MDC9JFAvODB3IN88US=> M1;rc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[xPFA{Lz5{NUC2NVgxOzxxYU6=
SW480 NGnDW2tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2\kXlQ5KGh? MnXvTWM2OCB;IECuNFA4KM7:TR?= M{HX[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[xPFA{Lz5{NUC2NVgxOzxxYU6=
A2780 NF7JU5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkTOOFghcA>? NXn6bph3UUN3MDC9JFAvODF3IN88US=> M3vGbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[xPFA{Lz5{NUC2NVgxOzxxYU6=
HCT8 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mlr6OFghcA>? MkDaTWM2OCB;IECuNFIyKM7:TR?= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB4MUiwN{c,OjVyNkG4NFM9N2F-
MCF7 NGnaTWFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmHlOFghcA>? MVHJR|UxKD1iMD6wNlMh|ryP NIHse2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC2NVgxOyd-MkWwOlE5ODN:L3G+
HepG2 MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NF;CVog1QCCq MkLDTWM2OCB;IECuNFI5KM7:TR?= NYTKU5VkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwOlE5ODNpPkK1NFYyQDB|PD;hQi=>
MCF7 M{XGVmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3u1b|Q5KGh? NEfIUmxKSzVyIE2gNE4xODRizszN NFTFT5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC4OFE1PCd-MkWwPFQyPDR:L3G+
A549 MULDfZRwfG:6aXPpeJkh[XO|YYm= MWm0PEBp NXrEdFFOUUN3MDC9JFAvODh{IN88US=> NXHITHVTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPFQyPDRpPkK1NFg1OTR2PD;hQi=>
COLO205 MkiwR5l1d3SxeHnjbZR6KGG|c3H5 Ml\sTWM2OCB;IECuNFA{KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB7MUmyOkc,OjVyOUG5NlY9N2F-
K562 MlHER5l1d3SxeHnjbZR6KGG|c3H5 NHLGZXc4OiCq M1X3bmlEPTBiPTCwMlAxPCEQvF2= NVnQXIFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVE6OjZpPkK1NFkyQTJ4PD;hQi=>
A431 NFHGeohEgXSxdH;4bYNqfHliYYPzZZk> M3H5OFczKGh? NEnORpFKSzVyIE2gNE4xODdizszN NXTT[4dvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVE6OjZpPkK1NFkyQTJ4PD;hQi=>
MDA-MB-435S NIjrRXBEgXSxdH;4bYNqfHliYYPzZZk> M3XUPFczKGh? MnPyTWM2OCB;IECuNFA6KM7:TR?= Mkf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOUG5NlYoRjJ3MEmxPVI3RC:jPh?=
NCI-H460 MVPDfZRwfG:6aXPpeJkh[XO|YYm= NIi4RXNKSzVyIE2gNE4xOSEQvF2= M4XNTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEmxPVI3Lz5{NUC5NVkzPjxxYU6=
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HepG2 MlPrR5l1d3SxeHnjbZR6KGG|c3H5 MYG3NkBp MmjSTWM2OCB;IECuPVkh|ryP NHfPOJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC5NVkzPid-MkWwPVE6OjZ:L3G+
MDA-MB-DYT2 MkfNR5l1d3SxeHnjbZR6KGG|c3H5 M4jtbVQh\GG7cx?= M4DoXmlEPTBiPTCwMlAxPjB6IN88US=> NHPpVYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC5PFUzQCd-MkWwPVg2Ojh:L3G+
MDA-MB-468 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NUfCbZZqPCCmYYnz M4r3[mlEPTBiPTCwMlAxPzF5IN88US=> NEXweZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC5PFUzQCd-MkWwPVg2Ojh:L3G+
NCI-N87 M1vQSWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF32VYQ1KGSjeYO= NYHWdJY4UUN3MDC9JFAvODB5NUOg{txO MoLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOUi1NlgoRjJ3MEm4OVI5RC:jPh?=
NCI-H1975 NGfud5BEgXSxdH;4bYNqfHliYYPzZZk> NIDjemw1KGSjeYO= M1j4XWlEPTBiPTCwMlAxPzl2IN88US=> MlHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOUi1NlgoRjJ3MEm4OVI5RC:jPh?=
BT474 MXfDfZRwfG:6aXPpeJkh[XO|YYm= MXG0JIRigXN? NInhcGdKSzVyIE2gNE4xODh|NjFOwG0> NXO4W25sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVg2OjhpPkK1NFk5PTJ6PD;hQi=>
DU145 M{\I[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NFLwUYZKSzVyIE2gNU42KM7:TR?= MnnQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzMEW3NlIoRjJ3MUC1O|IzRC:jPh?=
MCF7 MonUR5l1d3SxeHnjbZR6KGG|c3H5 NYWyT|k2UUN3MDC9JFEvQCEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTFyNUeyNkc,OjVzMEW3NlI9N2F-
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MCF7 MUjDfZRwfG:6aXPpeJkh[XO|YYm= NX3QVmJuPDhiaB?= Mne2TWM2OCB;IECuNkDPxE1? M1G0NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUe2N|I6Lz5{NUG3OlMzQTxxYU6=
NCI-H358 M4r2VGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M1;VclQ5KGh? M{Hzc2lEPTBiPTCwMlAxOiEQvF2= NX3UVFh7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNFg{PDVpPkK1NlA5OzR3PD;hQi=>
A2780S M1nFV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkLMOFghcA>? NYHKfGd[UUN3MDC9JFAvODB2IN88US=> NX;mWJdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNFg{PDVpPkK1NlA5OzR3PD;hQi=>
HCT8 MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M4[3bVQ5KGh? NFHLOI5KSzVyIE2gNE4xODVizszN Ml3IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MEizOFUoRjJ3MkC4N|Q2RC:jPh?=
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DLD1 MnXjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NID5VXM1QCCq M3zNTmlEPTBiPTCwMlAyPiEQvF2= MofNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MEizOFUoRjJ3MkC4N|Q2RC:jPh?=
HCT116 MlraRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MV60PEBp NUX3NlBbUUN3MDC9JFAvODF6IN88US=> NV3PeWJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNFg{PDVpPkK1NlA5OzR3PD;hQi=>
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U251 NHG5UmJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4DZZ|Q5KGh? MWDJR|UxKD1iMD6wNlMh|ryP NFvy[|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKwPFM1PSd-MkWyNFg{PDV:L3G+
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SMMC7721 MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NV7UO21DPzJiaB?= MWnJR|UxKD1iMD6xNkDPxE1? MnToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5N{G0PFQoRjJ3N{exOFg1RC:jPh?=
SMMC7721 NEDFcJpEgXSxdH;4bYNqfHliYYPzZZk> MlSyOFghcA>? NUXlSZJkUUN3MDC9JFAvODB6IN88US=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7OEWyPEc,OjV5OUi1Nlg9N2F-
HL60 M4rjVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmHVOFghcA>? MYnJR|UxKD1iMD6wNFgh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7OEWyPEc,OjV5OUi1Nlg9N2F-
A549 Mk\YR5l1d3SxeHnjbZR6KGG|c3H5 Ml3pOFghcA>? NEDWUHpKSzVyIE2gNE4xODhizszN NGLoO5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5PFUzQCd-MkW3PVg2Ojh:L3G+
MCF7 Ml3WR5l1d3SxeHnjbZR6KGG|c3H5 MVu0PEBp MlzRTWM2OCB;IECuNFA5KM7:TR?= NGftTVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5PFUzQCd-MkW3PVg2Ojh:L3G+
SW480 NEfHSIJEgXSxdH;4bYNqfHliYYPzZZk> NUnkUpE3PDhiaB?= M2TMbGlEPTBiPTCwMlAxQCEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7OEWyPEc,OjV5OUi1Nlg9N2F-
HL60 MUfDfZRwfG:6aXPpeJkh[XO|YYm= NYLEO2VCPzJiaB?= NVrVeGV2UUN3MDC9JFAvODBzODFOwG0> NGDWN|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVA6Pid-MkW4NVkxQTZ:L3G+
MOLT4 M{HlOWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF;GNnc4OiCq NWftWY5rUUN3MDC9JFAvODB{MjFOwG0> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzOUC5Okc,OjV6MUmwPVY9N2F-
U937 MkXzR5l1d3SxeHnjbZR6KGG|c3H5 MVS3NkBp MYPJR|UxKD1iMD6wNFI2KM7:TR?= MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzOUC5Okc,OjV6MUmwPVY9N2F-
HeLa Ml3zR5l1d3SxeHnjbZR6KGG|c3H5 MnX1O|IhcA>? NXftSWN5UUN3MDC9JFAvODB|MjFOwG0> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzOUC5Okc,OjV6MUmwPVY9N2F-
DU145 NVix[ZdjS3m2b4TvfIlkcXS7IHHzd4F6 MVq3NkBp NUT3NXJSUUN3MDC9JFAvODB|NDFOwG0> M3vmXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEG5NFk3Lz5{NUixPVA6PjxxYU6=
A549 NIfyenlEgXSxdH;4bYNqfHliYYPzZZk> M3K4U|czKGh? NXjS[4ZtUUN3MDC9JFAvODB2NDFOwG0> Ml:2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUmwPVYoRjJ3OEG5NFk3RC:jPh?=
SGC7901 M2D0VGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV63NkBp MUTJR|UxKD1iMD6wNFUyKM7:TR?= M4O0dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEG5NFk3Lz5{NUixPVA6PjxxYU6=
K562 M{XmOWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn;NO|IhcA>? MoTjTWM2OCB;IECuNFA2OiEQvF2= NEfvOJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVA6Pid-MkW4NVkxQTZ:L3G+
MCF7 Mn33R5l1d3SxeHnjbZR6KGG|c3H5 MVS3NkBp MXHJR|UxKD1iMD6wNFYzKM7:TR?= MnTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUmwPVYoRjJ3OEG5NFk3RC:jPh?=
NCI-H1975 M1LhUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NILDR5Y4OiCq MlTuTWM2OCB;IECuNFA4PyEQvF2= NUTZTVlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVkxQTZpPkK1PFE6ODl4PD;hQi=>
MX1 M{KyR2N6fG:2b4jpZ4l1gSCjc4PhfS=> Ml7pO|IhcA>? M4jDV2lEPTBiPTCwMlAxPTV7IN88US=> M1y2fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEG5N|M1Lz5{NUixPVM{PDxxYU6=
ID8 MVTDfZRwfG:6aXPpeJkh[XO|YYm= NHvjelA4OiCq MYjJR|UxKD1iMD6wNVM5KM7:TR?= NELGTWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVM{PCd-MkW4NVk{OzR:L3G+
L1210 MWXDfZRwfG:6aXPpeJkh[XO|YYm= MVi3NkBp M2n0ZmlEPTBiPTCwMlAzPzZizszN NHy2RpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVM{PCd-MkW4NVk{OzR:L3G+
WI38 MUXDfZRwfG:6aXPpeJkh[XO|YYm= M2nsWVczKGh? MknyTWM2OCB;IECuNFU2PyEQvF2= MkHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUmzN|QoRjJ3OEG5N|M1RC:jPh?=
MDA-MB-231 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWi0PEBp MX;HTVUxKD1iMD6wNUDPxE1? NH7xT409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyO|UzOid-MkW4Nlc2OjJ:L3G+
A549 MnjDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUm0PEBp NITOVpZIUTVyIE2gNE4xOSEQvF2= MlnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6Mke1NlIoRjJ3OEK3OVIzRC:jPh?=
PANC1 MlfURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVrOdYNiPDhiaB?= MnrwS2k2OCB;IECuNFEzKM7:TR?= M4PVVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO|UzOjxxYU6=
HeLa NIXS[XNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NYPmSnBrPDhiaB?= NUHxVVBLT0l3MDC9JFAvODJizszN MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{N{WyNkc,OjV6Mke1NlI9N2F-
HEK293 NWHxcmZ[S3m2b4TvfIlkcXS7IHHzd4F6 NFvDVnY4OiCq MkL0TWM2OCB;IECuNFQh|ryP NIC1dJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi0NlM3PCd-MkW4OFI{PjR:L3G+
SW480 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MlzXOFghcA>? NWH4XFF1UUN3MDC9JFAvODB6IN88US=> NHjoPJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3NVI3OSd-MkW4O|EzPjF:L3G+
HL60 NHL6fmZEgXSxdH;4bYNqfHliYYPzZZk> MWS0PEBp NG\COVZKSzVyIE2gNE4xODhizszN MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5MUK2NUc,OjV6N{GyOlE9N2F-
MCF7 M4fTZmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2rvcVQ5KGh? M4jSTmlEPTBiPTCwMlAxQCEQvF2= MnLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{GyOlEoRjJ3OEexNlYyRC:jPh?=
SMMC7721 MX;DfZRwfG:6aXPpeJkh[XO|YYm= MWG0PEBp MWjJR|UxKD1iMD6wNFgh|ryP M1vxWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEexNlYyLz5{NUi3NVI3OTxxYU6=
A549 MoDVR5l1d3SxeHnjbZR6KGG|c3H5 NV3PZ41QPDhiaB?= MXfJR|UxKD1iMD6wNFgh|ryP NVPC[4NrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|EzPjFpPkK1PFcyOjZzPD;hQi=>
SCC114 M3LJemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWftXJdlPzJiaB?= MUHJR|UxKD1iMD6wNFA{KM7:TR?= NYnEeGJzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|I6QDRpPkK1PFczQTh2PD;hQi=>
HeLa NVTiUmpzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MkTHOFghcA>? M3fONWlEPTBiPTCwMlAxOTlizszN MkHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6OEK1NVkoRjJ3OEiyOVE6RC:jPh?=
MDA-MB-435 M4XjS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Ml\DOFghcA>? M3\0fGlEPTBiPTCwMlAxOzNizszN NYrjVWh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFI2OTlpPkK1PFgzPTF7PD;hQi=>
SKOV3 NUf1OVJ6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1S5elQ5KGh? NXP6d5puUUN3MDC9JFAvODB4MzFOwG0> NGi5cFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
SKOV3-MDR1-M6/6 MmL0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYO0PEBp NITmc4lKSzVyIE2gNU4yQDd{IN88US=> NUHTR5ZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4PFI2OTlpPkK1PFgzPTF7PD;hQi=>
A549 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NHnYUpM1QCCq NWnhTFRGUUN3MDC9JFAvODB{MzFOwG0> NXTNdIJPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|czOzZpPkK1PVM4OjN4PD;hQi=>
taxol-resistant A549 NGTJZ2ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkDuOFghcA>? Ml7xTWM2OCB;IECuOVIh|ryP M4nzclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO3NlM3Lz5{NUmzO|I{PjxxYU6=
EL4 NHTSVmREgXSxdH;4bYNqfHliYYPzZZk> MknkOFghcA>? NH:3bXpKSzVyIE2gNU44KM7:TR?= NInQcVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm1NVA2Pyd-MkW5OVExPTd:L3G+
HeLa NWTUcIl{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mmj6OFghcA>? NUe0coRPUUN3MDC9JFAvOzhizszN NGjlRno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm1PVgyOyd-MkW5OVk5OTN:L3G+
A549 NWWzNm5bSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3\udlQ5KGh? NGH5OZRKSzVyIE2gNk45OiEQvF2= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl3OUixN{c,OjV7NUm4NVM9N2F-
LCC-6 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NGm2V4M{KGSjeYO= NV7jPFBWUUN3MDC9JFAvODBzNjFOwG0> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl6NUG5OUc,OjV7OEWxPVU9N2F-
MDA435/LCC6MDR MlLOR5l1d3SxeHnjbZR6KGG|c3H5 MlTZN{Bl[Xm| M1XlbmlEPTBiPTCwMlE1PDZizszN M17HWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUi1NVk2Lz5{NUm4OVE6PTxxYU6=
A2780 Mk\iRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYCyJIRigXN? MkPNTWM2OCB;IECuNFI5KM7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB2MkS3NEc,OjZyNEK0O|A9N2F-
SMMC7721 MomxR5l1d3SxeHnjbZR6KGG|c3H5 MVO0PEBp MVzJR|UxKD1iMD6wNFgh|ryP NXzVZWNSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wOlg5ODJpPkK2NFY5QDB{PD;hQi=>
HL60 NW\DVZhmS3m2b4TvfIlkcXS7IHHzd4F6 M2LNRlQ5KGh? MkTYTWM2OCB;IECuNFA5KM7:TR?= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB4OEiwNkc,OjZyNki4NFI9N2F-
MCF7 M2XUTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF[0eYQ1QCCq NVzpVGdkUUN3MDC9JFAvODB6IN88US=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB4OEiwNkc,OjZyNki4NFI9N2F-
A549 NWjCNFE6S3m2b4TvfIlkcXS7IHHzd4F6 NIHHRlI1QCCq MXXJR|UxKD1iMD6wNFgh|ryP NFnJXFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC2PFgxOid-Mk[wOlg5ODJ:L3G+
SW480 MlPjR5l1d3SxeHnjbZR6KGG|c3H5 NVP2e5NmPDhiaB?= MYHJR|UxKD1iMD6wNFgh|ryP M4K3W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4ME[4PFAzLz5{NkC2PFgxOjxxYU6=
BEAS2B NVGxXXNqS3m2b4TvfIlkcXS7IHHzd4F6 Mof4OFghcA>? MlHCTWM2OCB;IECuOVgh|ryP MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB4OEiwNkc,OjZyNki4NFI9N2F-
NB4 NI\r[|lEgXSxdH;4bYNqfHliYYPzZZk> NXTV[INqPDhiaB?= NHjpTWhKSzVyIE2gNE4xODJ|IN88US=> MkP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
NCI-H1975 M3v2fWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXu3NkBp NVT5WmlFUUN3MDC9JFAvODB{NTFOwG0> NHvreHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzNlA4PSd-Mk[xN|IxPzV:L3G+
OVCAR8 NFrRO5BEgXSxdH;4bYNqfHliYYPzZZk> NHzMeJg1QCCq MlnETWM2OCB;IECuNFA{PyEQvF2= NYfhbJZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
MESSA NHnXeohEgXSxdH;4bYNqfHliYYPzZZk> MkfNO|IhcA>? MmT4TWM2OCB;IECuNFA1KM7:TR?= NVLpZpl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
MDA-MB-468 MYjDfZRwfG:6aXPpeJkh[XO|YYm= NH36enY4OiCq NGfkWZBKSzVyIE2gNE4xODVizszN NIX6enM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzNlA4PSd-Mk[xN|IxPzV:L3G+
A549 M{C4RmN6fG:2b4jpZ4l1gSCjc4PhfS=> M{PTSVczKGh? NHHPPFlKSzVyIE2gNE4xODdizszN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|MkC3OUc,OjZzM{KwO|U9N2F-
MDA-MB-231 MnLzR5l1d3SxeHnjbZR6KGG|c3H5 MnPHO|IhcA>? MmPjTWM2OCB;IECuNFA4KM7:TR?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|MkC3OUc,OjZzM{KwO|U9N2F-
MDA-MB-436 MojvR5l1d3SxeHnjbZR6KGG|c3H5 MYG3NkBp M{fmSWlEPTBiPTCwMlAxQCEQvF2= NH;Pe5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzNlA4PSd-Mk[xN|IxPzV:L3G+
MESSA/DX5 NYnVPGJxS3m2b4TvfIlkcXS7IHHzd4F6 NFXKeJQ4OiCq MWPJR|UxKD1iMT63OlQh|ryP NXWzXZJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
HepG2 NWTCd45WS3m2b4TvfIlkcXS7IHHzd4F6 M1X6UlQ5KGh? M{fYRmlEPTBiPTCyMlYh|ryP NI\DdXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGzNlA4PSd-Mk[xN|IxPzV:L3G+
PC3 NETPXGVEgXSxdH;4bYNqfHliYYPzZZk> M4rqVlQ5KGh? NFnCenZKSzVyIE2gOE46KM7:TR?= MoXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
NCI-ADR-RES NXvIfI84S3m2b4TvfIlkcXS7IHHzd4F6 Mo\yOFghcA>? M3OzdGlEPTBiPTC2JO69VQ>? M162SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUOyNFc2Lz5{NkGzNlA4PTxxYU6=
KB M{j5T2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MW[3NkBp NWLBPVZlUUN3MDC9JFAvODB3MTFOwG0> NWDsclJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xOlAxOjBpPkK2NVYxODJyPD;hQi=>
KB-7d MnXzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYe3NkBp MnHzTWM2OCB;IECuNFA5PCEQvF2= M37k[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MU[wNFIxLz5{NkG2NFAzODxxYU6=
KB-S15 MkjmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Ml30O|IhcA>? NVjaUoU5UUN3MDC9JFAvOTN3IN88US=> M4L1e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MU[wNFIxLz5{NkG2NFAzODxxYU6=
DU145 Mm\RRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NUPLdZVRT0l3MDC9JFAvODB4IN88US=> NFqzTIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK0NlI1Oid-Mk[yOFIzPDJ:L3G+
KB Ml6wRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NF;uS5VIUTVyIE2gNE4xODZ2IN88US=> Mny3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NEKyOFIoRjJ4MkSyNlQzRC:jPh?=
A549 M4Kw[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MljHS2k2OCB;IECuNFA4PiEQvF2= MlXKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NEKyOFIoRjJ4MkSyNlQzRC:jPh?=
vincristine-resistant KBVIN NUDid|QzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmPNS2k2OCB;IEGuNlEh|ryP NUfGRXl3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOFIzPDJpPkK2NlQzOjR{PD;hQi=>
K562 MonJR5l1d3SxeHnjbZR6KGG|c3H5 Mnv5TWM2OCB;IECuPUDPxE1? MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ6N{SwNUc,OjZ{OEe0NFE9N2F-
U937 NV7YfJBnS3m2b4TvfIlkcXS7IHHzd4F6 M1LOXVczKGh? Ml\kTWM2OCB;IEKuNUDPxE1? MnHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MU[0OlcoRjJ4M{G2OFY4RC:jPh?=
A549 MVPDfZRwfG:6aXPpeJkh[XO|YYm= MlLHO|IhcA>? NEjLRXVKSzVyIE2gNk4yKM7:TR?= NXrvVVNIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVY1PjdpPkK2N|E3PDZ5PD;hQi=>
MCF7 NIPrfW5EgXSxdH;4bYNqfHliYYPzZZk> M2DRUFczKGh? M{LwbWlEPTBiPTCyMlMh|ryP M1m4blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{G2OFY4Lz5{NkOxOlQ3PzxxYU6=
MOLT4 MWfDfZRwfG:6aXPpeJkh[XO|YYm= NG\sd4g4OiCq MU\JR|UxKD1iMj63JO69VQ>? NEPQRWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxOlQ3Pyd-Mk[zNVY1Pjd:L3G+
NCI-H1975 M2\NbmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2P6PFczKGh? NFzmUpdKSzVyIE2gNk45KM7:TR?= NHrnVlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxOlQ3Pyd-Mk[zNVY1Pjd:L3G+
HeLa NEDPNHBEgXSxdH;4bYNqfHliYYPzZZk> MljjO|IhcA>? MVrJR|UxKD1iMj65JO69VQ>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzNkS2O{c,OjZ|MU[0Olc9N2F-
DU145 M4nSdGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIS3bJg4OiCq NVXNUWZVUUN3MDC9JFMvOSEQvF2= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzNkS2O{c,OjZ|MU[0Olc9N2F-
K562 NIPR[3JEgXSxdH;4bYNqfHliYYPzZZk> NI\aTGc4OiCq NHjv[Y9KSzVyIE2gN{45KM7:TR?= NVTrbZY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVY1PjdpPkK2N|E3PDZ5PD;hQi=>
HL60 NXfIVmptS3m2b4TvfIlkcXS7IHHzd4F6 NYjPXIdSPzJiaB?= NEDZNmFKSzVyIE2gN{45KM7:TR?= MlTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MU[0OlcoRjJ4M{G2OFY4RC:jPh?=
SGC7901 MnPjR5l1d3SxeHnjbZR6KGG|c3H5 MoPsO|IhcA>? NXjuW4RDUUN3MDC9JFkvQCEQvF2= NF3pZlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxOlQ3Pyd-Mk[zNVY1Pjd:L3G+
MES-SA MWjDfZRwfG:6aXPpeJkh[XO|YYm= MV:0PEBp MWDHTVUxKD1iMD6wNFch|ryP MkPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NkCwOFcoRjJ4M{[wNFQ4RC:jPh?=
Rhabdomyosarcoma NF21UZNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M4\VNFk3KGh? MXTJR|UxKD1iMD6wNFg1KM7:TR?= NWfmPZpzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zPFY5OThpPkK2N|g3QDF6PD;hQi=>
HT-29 MkXwR5l1d3SxeHnjbZR6KGG|c3H5 NUTPfFlXOyCmYYnz NWPvfJBLUUN3MDC9JFAvODByODFOwG0> NWnOd3R2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0NlIyOzFpPkK2OFIzOTNzPD;hQi=>
MDA-MB-231 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MlrOO|IhcA>? NFPCSGlKSzVyIE2gNE4xODFizszN M124flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NES4NFM4Lz5{NkS0PFA{PzxxYU6=
PC3 NX30fYQ6S3m2b4TvfIlkcXS7IHHzd4F6 MUi3NkBp NV;hO|g3UUN3MDC9JFAvODBzIN88US=> NWLnWIFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OFgxOzdpPkK2OFQ5ODN5PD;hQi=>
HCT116 NW\qcWh3S3m2b4TvfIlkcXS7IHHzd4F6 MmC2OFghcA>? MVnJR|UxKD1iMD6wNFI5KM7:TR?= NGX3Vpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS0PFA{Pyd-Mk[0OFgxOzd:L3G+
A549 NYXZbnNHS3m2b4TvfIlkcXS7IHHzd4F6 MnHkTWM2OCB;IECuNFA3OyEQvF2= MmSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NEiwN|coRjJ4NES4NFM4RC:jPh?=
HepG2 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NHLmdoI1QCCq MkfzTWM2OCB;IEGuNlE4KM7:TR?= M3m5V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NES4NFM4Lz5{NkS0PFA{PzxxYU6=
H460 NHrlNYREgXSxdH;4bYNqfHliYYPzZZk> Mmi3OFghcA>? MlXaTWM2OCB;IESuNlg4KM7:TR?= MkK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NEiwN|coRjJ4NES4NFM4RC:jPh?=
cells after 48 hrs by SRB assay NXntSFB6S3m2b4TvfIlkcXS7IHHzd4F6 NGjNO4hIUTVyIE2gNE4xODF2ODFOwG0> NWrlepRVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlIxPTJpPkK2OFYzODV{PD;hQi=>
HeLa NIHJemtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MmPBO|IhcA>? M37ufmlEPTBiPTCyMlI6KM7:TR?= NWPTdmRxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NFI5OjdpPkK2OlAzQDJ5PD;hQi=>
184B5 NVOz[YNFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NV7tSGR[PzJiaB?= NH\wc4pKSzVyIE2gNk4{OiEQvF2= NHXIWII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wNlgzPyd-Mk[2NFI5Ojd:L3G+
MDA-MB-231 M1vWcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NV;CUpVXPzJiaB?= MYXJR|UxKD1iMj61OkDPxE1? NVTwfY5mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NFI5OjdpPkK2OlAzQDJ5PD;hQi=>
MDA-MB-468 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVq3NkBp MVzJR|UxKD1iMz64O{DPxE1? NVjIZnk1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2NFI5OjdpPkK2OlAzQDJ5PD;hQi=>
MCF7 NVT0VmZ4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVq3NkBp MVPJR|UxKD1iMz65PUDPxE1? M1f0OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkCyPFI4Lz5{Nk[wNlgzPzxxYU6=
Jurkat NGra[ZBEgXSxdH;4bYNqfHliYYPzZZk> NIXjS|k1QCCq M1fte2lEPTBiPTCwMlAxODVizszN NVrEU|FWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|gxPDFpPkK2OlM5ODRzPD;hQi=>
U937 NFPV[ZZEgXSxdH;4bYNqfHliYYPzZZk> M2j6fFQ5KGh? MWnJR|UxKD1iMD6wNFYh|ryP M2WyO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkO4NFQyLz5{Nk[zPFA1OTxxYU6=
HeLa NXHGdnZwS3m2b4TvfIlkcXS7IHHzd4F6 MV20PEBp NE\LSG9KSzVyIE2gNE4xQTlizszN MoTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{iwOFEoRjJ4NkO4NFQyRC:jPh?=
cells assessed as cell growth inhibition after 48 hrs by MTT assay MVPDfZRwfG:6aXPpeJkh[XO|YYm= NEi3R2tKSzVyIE2gNE43PSEQvF2= Mkm3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{iwOFEoRjJ4NkO4NFQyRC:jPh?=
MDA-MB-231 MlPnR5l1d3SxeHnjbZR6KGG|c3H5 MVy3NkBp MVfJR|UxKD1iMD6wNFM6KM7:TR?= M2m4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkmwNlc1Lz5{Nk[5NFI4PDxxYU6=
MCF7 NF;0UndEgXSxdH;4bYNqfHliYYPzZZk> M2qzbVczKGh? MVnJR|UxKD1iMD6wNFc1KM7:TR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ7MEK3OEc,OjZ4OUCyO|Q9N2F-
U937 NH7PfnFEgXSxdH;4bYNqfHliYYPzZZk> MY[3NkBp NIrvN3dKSzVyIE2gNE4xODF4NjFOwG0> MonmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4OUe3NVgoRjJ4Nkm3O|E5RC:jPh?=
HL60 M2X5cWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4HK[FczKGh? NYezOIJzUUN3MDC9JFAvODBzOUmg{txO MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ7N{exPEc,OjZ4OUe3NVg9N2F-
A549 MkGxR5l1d3SxeHnjbZR6KGG|c3H5 NWm4N5dCPzJiaB?= NXS2c481UUN3MDC9JFAvODB{MUKg{txO MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ7N{exPEc,OjZ4OUe3NVg9N2F-
DU145 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NFn5TpY4OiCq NHTn[ZlKSzVyIE2gNE4xODJ|IN88US=> NWnDVHJYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2PVc4OThpPkK2Olk4PzF6PD;hQi=>
HeLa MWHDfZRwfG:6aXPpeJkh[XO|YYm= M3;yU|czKGh? MkK5TWM2OCB;IECuNFA{ODFizszN NW\ic5VjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2PVc4OThpPkK2Olk4PzF6PD;hQi=>
HT-29 MkLqR5l1d3SxeHnjbZR6KGG|c3H5 NV24ZnVWPzJiaB?= NWfpSVBnUUN3MDC9JFAvODB|MESg{txO MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ7N{exPEc,OjZ4OUe3NVg9N2F-
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MDA-MB-231 NIPxTllCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M1n4NlQ5KGh? MYnHTVUxKD1iMD6wNUDPxE1? M1TzOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUm0OlkxLz5{Nkm5OFY6ODxxYU6=
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A2780 M{fqbGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnrtOFghcA>? M3ft[GlEPTBiPTCwMlAxPSEQvF2= NVnEUGc5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexOFk3PDFpPkK3NVQ6PjRzPD;hQi=>
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HL-7702 MXvDfZRwfG:6aXPpeJkh[XO|YYm= MYi3NkBp MVjJR|UxKD1iMD6wOkDPxE1? NXf1dXdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezNlk6OzhpPkK3N|I6QTN6PD;hQi=>
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HepG2 M4PDOWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2LzTlczKGh? NFjTOW1KSzVyIE2gNE4zKM7:TR?= M3jReVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5M{K5PVM5Lz5{N{OyPVk{QDxxYU6=
MCF7 M1G0TGN6fG:2b4jpZ4l1gSCjc4PhfS=> NI\WbVY6PiCq MV7JR|UxKD1iMD6wNFAzKM7:TR?= M4HxTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NEO0OFI3Lz5{N{SzOFQzPjxxYU6=
HeLa NUPa[ppmS3m2b4TvfIlkcXS7IHHzd4F6 MXG5OkBp NXTEZoRIUUN3MDC9JFAvODB4NDFOwG0> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR|NESyOkc,Ojd2M{S0NlY9N2F-
MCF7 MoXwR5l1d3SxeHnjbZR6KGG|c3H5 MYDJR|UxKD1iMD6wNFA3KM7:TR?= NIXUUFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{S0NVg6Oid-Mke0OFE5QTJ:L3G+
HCT116 NHzo[HhEgXSxdH;4bYNqfHliYYPzZZk> M4XScWlEPTBiPTCwMlAxODlizszN MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2MUi5Nkc,Ojd2NEG4PVI9N2F-
BGC823 NUTneI5jS3m2b4TvfIlkcXS7IHHzd4F6 MVHJR|UxKD1iMD6wNFM{KM7:TR?= MnXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEG4PVIoRjJ5NESxPFkzRC:jPh?=
HepG2 M{DRVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX;jbIJXUUN3MDC9JFAvODF{IN88US=> MoLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEG4PVIoRjJ5NESxPFkzRC:jPh?=
Capan2 NGLqS3ZEgXSxdH;4bYNqfHliYYPzZZk> M4T1bGlEPTBiPTCwMlAyPyEQvF2= M4rMclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NESxPFkzLz5{N{S0NVg6OjxxYU6=
A375 M4rCZWN6fG:2b4jpZ4l1gSCjc4PhfS=> MY\JR|UxKD1iMD6wNlIh|ryP Mnr0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEG4PVIoRjJ5NESxPFkzRC:jPh?=
A549 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NXTmc|dQUUN3MDC9JFAvODJ|IN88US=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2MUi5Nkc,Ojd2NEG4PVI9N2F-
A2780 M{\sT2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3zQcmlEPTBiPTCwMlA{QCEQvF2= M2W5T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NESxPFkzLz5{N{S0NVg6OjxxYU6=
NCI-H1650 MXnDfZRwfG:6aXPpeJkh[XO|YYm= MljyTWM2OCB;IECuNFY5KM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzR2MUi5Nkc,Ojd2NEG4PVI9N2F-
NCI60 NH\XfoREgXSxdH;4bYNqfHliYYPzZZk> M3vSWlQ5KGh? NFvmfXJIUTVyIE2gNE4xOzF3IN88US=> MmHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NlQoRjJ5NES4PVI1RC:jPh?=
HepG2 NXrxWmFpS3m2b4TvfIlkcXS7IHHzd4F6 M122SFQ5KGh? MkT5TWM2OCB;IECuNFA3KM7:TR?= M2jjOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkK3NVMxLz5{N{[yO|E{ODxxYU6=
Hep3B M2\RPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGriZpM1QCCq M2\sZ2lEPTBiPTCwMlAzKM7:TR?= M1\k[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NkK3NVMxLz5{N{[yO|E{ODxxYU6=
A549 MkfHR5l1d3SxeHnjbZR6KGG|c3H5 MXi0PEBp M{XNXWlEPTBiPTCwMlA{KM7:TR?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ{N{GzNEc,Ojd4MkexN|A9N2F-
MCF7 M{XpRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUm3UXpnPDhiaB?= M2PlO2lEPTBiPTCwMlA3KM7:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ{N{GzNEc,Ojd4MkexN|A9N2F-
A549 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MYW0PEBp M3j0RmlEPTBiPTCwMlAxQCEQvF2= MmPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MES4NFcoRjJ5N{C0PFA4RC:jPh?=
SW480 NY\MXXNrS3m2b4TvfIlkcXS7IHHzd4F6 MVO0PEBp M3TpV2lEPTBiPTCwMlAxQCEQvF2= NVPFS5g2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NFQ5ODdpPkK3O|A1QDB5PD;hQi=>
HL60 NULRe|U5S3m2b4TvfIlkcXS7IHHzd4F6 NX\zWFliPDhiaB?= M3jmZWlEPTBiPTCwMlAxQCEQvF2= NXjpOXVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NFQ5ODdpPkK3O|A1QDB5PD;hQi=>
SMMC7721 MnfsR5l1d3SxeHnjbZR6KGG|c3H5 MkfQOFghcA>? MofMTWM2OCB;IECuNFA5KM7:TR?= MlHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MES4NFcoRjJ5N{C0PFA4RC:jPh?=
MCF7 M{\zPWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mmr5OFghcA>? Ml73TWM2OCB;IECuNFA5KM7:TR?= MkXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MES4NFcoRjJ5N{C0PFA4RC:jPh?=
HeLa Mn;5R5l1d3SxeHnjbZR6KGG|c3H5 NXfWRXc2PDhiaB?= MVfJR|UxKD1iMD6wNFgh|ryP MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdyNEiwO{c,Ojd5MES4NFc9N2F-
A549 M1SxVGN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml7QOFghcA>? MnjPTWM2OCB;IECuNFIh|ryP MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdyNEiyNkc,Ojd5MES4NlI9N2F-
MCF7 NVz6R|NRS3m2b4TvfIlkcXS7IHHzd4F6 M1zRT|Q5KGh? Mlv5TWM2OCB;IECuNUDPxE1? NXexd2FKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NFQ5OjJpPkK3O|A1QDJ{PD;hQi=>
HeLa MXrDfZRwfG:6aXPpeJkh[XO|YYm= NFrrV3U4OiCq NXf1R4dJUUN3MDC9JFEvPyEQvF2= M2DpOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVk2Lz5{N{e0PFU6PTxxYU6=
K562 M1f1TWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYW3NkBp M1rCRmlEPTBiPTCyMlch|ryP MlfKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NEi1PVUoRjJ5N{S4OVk2RC:jPh?=
HCT116 NGX0emJEgXSxdH;4bYNqfHliYYPzZZk> NH76Zmw4OiCq M3vPOWlEPTBiPTCzMlMh|ryP NFLPdW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e0PFU6PSd-Mke3OFg2QTV:L3G+
A549 M2XEe2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWO3NkBp NHnnNpBKSzVyIE2gOU42KM7:TR?= MlfuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NEi1PVUoRjJ5N{S4OVk2RC:jPh?=
HepG2 NXTBfXViS3m2b4TvfIlkcXS7IHHzd4F6 MnjuO|IhcA>? MorLTWM2OCB;IE[uO{DPxE1? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd2OEW5OUc,Ojd5NEi1PVU9N2F-
HELF NGHDZ2ZEgXSxdH;4bYNqfHliYYPzZZk> M336TFI1KGh? MUXJR|UxKD1iNz6xOEDPxE1? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4OUCzNUc,Ojd5NkmwN|E9N2F-
BGC823 M33OTGN6fG:2b4jpZ4l1gSCjc4PhfS=> M1\iPVI1KGh? MnqwTWM2OCB;IEmuNlYh|ryP NU\Hb3lWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OlkxOzFpPkK3O|Y6ODNzPD;hQi=>
KB M4LCXWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4LkZVQ5KGh? MnqxTWM2OCB;IECuNFAxQCEQvF2= M4i5d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{m3NVkzLz5{N{e5O|E6OjxxYU6=
A549 M{C3[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MWG0PEBp M3Pk[GlEPTBiPTCwMlAxODl7IN88US=> NEnmOY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e5O|E6Oid-Mke3PVcyQTJ:L3G+
MDA-MB-231 MV\DfZRwfG:6aXPpeJkh[XO|YYm= M2jPd|Q5KGh? NV3v[5k6UUN3MDC9JFAvODB|MEWg{txO M3SyNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{m3NVkzLz5{N{e5O|E6OjxxYU6=
MCF7 NWTwNIVXS3m2b4TvfIlkcXS7IHHzd4F6 M4rnXFQ5KGh? MkLmTWM2OCB;IECuNFIzPzVizszN Mlz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5OUexPVIoRjJ5N{m3NVkzRC:jPh?=
KBVIN MXHDfZRwfG:6aXPpeJkh[XO|YYm= M1S1S|Q5KGh? NFLIVVRKSzVyIE2gNU45QTZizszN NG\UR249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e5O|E6Oid-Mke3PVcyQTJ:L3G+
HCT116 NVnXUGxZS3m2b4TvfIlkcXS7IHHzd4F6 NVnSVIh2PDhiaB?= NIi3W4JKSzVyIE2gNE4yKM7:TR?= MlrFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6OEe4OFMoRjJ5OEi3PFQ{RC:jPh?=
Bel7402 NFzmclNEgXSxdH;4bYNqfHliYYPzZZk> MlzwOFghcA>? NHjTPWxKSzVyIE2gNE4yKM7:TR?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzh6N{i0N{c,Ojd6OEe4OFM9N2F-
OVCAR8 MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYS5OkBp MXnJR|UxKD1iNTFOwG0> MmLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6OUS1PFkoRjJ5OEm0OVg6RC:jPh?=
HeLa M1XwZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVXYVo5xQTZiaB?= NVrF[4cxUUN3MDC9JFUvOyEQvF2= NFr5W|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i5OFU5QSd-Mke4PVQ2QDl:L3G+
HeLa NGm4dZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnvYOFghcA>? NEjNS3NIUTVyIE2gNE4xOzh7IN88US=> NWTiXIpDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlQ5QDNpPkK3PVY1QDh|PD;hQi=>
MiaPaCa MmroS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUDTWJZzPDhiaB?= NFTuU2dIUTVyIE2gNE4xPiEQvF2= M{jObFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[0PFg{Lz5{N{m2OFg5OzxxYU6=
IMR32 MlzUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV[0PEBp M4OzcWdKPTBiPTCwMlA5PiEQvF2= NF;XVG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2OFg5Oyd-Mke5OlQ5QDN:L3G+
MDA-MB-231 NX;mXol5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIPhN|c1QCCq MlHWS2k2OCB;IECuNFkzKM7:TR?= NVniUY1oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlQ5QDNpPkK3PVY1QDh|PD;hQi=>
DU145 NVXvdVBNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEmzb2Y1QCCq MmDJTWM2OCB;IECuNFEyKM7:TR?= NWr4c|VPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5O|k2QTNpPkK3PVc6PTl|PD;hQi=>
HeLa MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MV[0PEBp NYn6TFF4UUN3MDC9JFAvODN4IN88US=> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl5OUW5N{c,Ojd7N{m1PVM9N2F-
MCF7 NVfGPXZVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M12zW|Q5KGh? M4jOU2lEPTBiPTCwMlY{KM7:TR?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl5OUW5N{c,Ojd7N{m1PVM9N2F-
ECA109 NW\Ze4xjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4jHdVQ5KGh? NEO4XppKSzVyIE2gNE46PCEQvF2= MnzKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7N{m1PVMoRjJ5OUe5OVk{RC:jPh?=
MDA-MB-435 NHfINIpEgXSxdH;4bYNqfHliYYPzZZk> MojxO|IhcA>? M3rvbmlEPTBiPTCwMlAxODJizszN M4T3SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUizPFQzLz5{N{m4N|g1OjxxYU6=
HT-29 NVz0[mo1S3m2b4TvfIlkcXS7IHHzd4F6 NVfHSYM2PzJiaB?= NVW4NXNLUUN3MDC9JFAvODByODFOwG0> M{\sd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUizPFQzLz5{N{m4N|g1OjxxYU6=
MDA-MB-231 M{P3fGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUjjbmlVPzJiaB?= MnPSTWM2OCB;IECuNFAzPyEQvF2= NX3JZpJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFM5PDJpPkK3PVg{QDR{PD;hQi=>
OVCAR3 MYHDfZRwfG:6aXPpeJkh[XO|YYm= M3K1[lczKGh? NIjxR4dKSzVyIE2gNE4xODN|IN88US=> M1roWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUizPFQzLz5{N{m4N|g1OjxxYU6=
H1299 NV7TfHhMS3m2b4TvfIlkcXS7IHHzd4F6 NGK1[nQzPCCq NXvV[HhXUUN3MDC9JFEvPSEQvF2= NW\zXW1{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFM5PDJpPkK3PVg{QDR{PD;hQi=>
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MDA-MB-231 MX3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1T4S|czKGh? MU\JR|UxKD1iMD6wNFg5KM7:TR?= NXSzcoZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPVA3QThpPkK4NlkxPjl6PD;hQi=>
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NCI-H460 M4nsZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkPqO|IhcA>? M1TIcmlEPTBiPTCwMlAyKM7:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN|NU[wOkc,Ojh|M{W2NFY9N2F-
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A549 NVP4V4lVS3m2b4TvfIlkcXS7IHHzd4F6 NVvBWWp6PDhiaB?= NUX5NHBuUUN3MDC9JFAvODB7NUKg{txO MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN2MESxNUc,Ojh|NEC0NVE9N2F-
A549/TR NWTodmNmS3m2b4TvfIlkcXS7IHHzd4F6 MYS0PEBp NGDyT2FKSzVyIE2gNU42OSEQvF2= MnP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|NEC0NVEoRjJ6M{SwOFEyRC:jPh?=
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HepG2 Mn\hR5l1d3SxeHnjbZR6KGG|c3H5 NHLObIE6PiCq MVnJR|UxKD1iMD6wNFY{KM7:TR?= NX;EcY1PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1N|A5OjhpPkK4OVMxQDJ6PD;hQi=>
OVPF008 MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MX:2JIRigXN? NVHzd404UUN3MDC9JFEvOSEQvF2= NI\wO3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0PFgzPSd-Mki1OFg5OjV:L3G+
OVPF038 NEfOWJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NF:xRnU3KGSjeYO= NGTlcnlKSzVyIE2gNU41KM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2OEiyOUc,Ojh3NEi4NlU9N2F-
KB MoHvR5l1d3SxeHnjbZR6KGG|c3H5 MmCxO|IhcA>? M1XpNWlEPTBiPTCwMlAxOzZizszN M2S3dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUmwNVI1Lz5{OEW5NFEzPDxxYU6=
KBv200 NWj6em5uS3m2b4TvfIlkcXS7IHHzd4F6 MVu3NkBp MnjETWM2OCB;IEKuNVE4KM7:TR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV7MEGyOEc,Ojh3OUCxNlQ9N2F-
MDA-MB-435 NYmxfHBWS3m2b4TvfIlkcXS7IHHzd4F6 NVTGWYlRPzJiaB?= MXvJR|UxKD1iMD6wNFA2KM7:TR?= NYrXNJRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1PVQyPjlpPkK4OVk1OTZ7PD;hQi=>
OVCAR3 M37KZmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkX6O|IhcA>? MmjTTWM2OCB;IECuNFAzKM7:TR?= MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3OUSxOlkoRjJ6NUm0NVY6RC:jPh?=
MDA-MB-231 NVnkeolES3m2b4TvfIlkcXS7IHHzd4F6 M{HwNlczKGh? MmjGTWM2OCB;IECuNFA6KM7:TR?= NILZb2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW5OFE3QSd-Mki1PVQyPjl:L3G+
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HL60 M{PCRWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2XROlczKGh? NYXndHhTUUN3MDC9JFAvODB{IN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV7OE[zN{c,Ojh3OUi2N|M9N2F-
A549 NY\4dJEzS3m2b4TvfIlkcXS7IHHzd4F6 M{TzbVczKGh? MlTMTWM2OCB;IECuNFAzOSEQvF2= NHH1[FA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW5PFY{Oyd-Mki1PVg3OzN:L3G+
DU145 M1r3emN6fG:2b4jpZ4l1gSCjc4PhfS=> M{fBT|czKGh? MnraTWM2OCB;IECuNFAzOyEQvF2= M37EdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUm4OlM{Lz5{OEW5PFY{OzxxYU6=
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HT-29 Mn7QR5l1d3SxeHnjbZR6KGG|c3H5 MkfWO|IhcA>? NWS2OZBjUUN3MDC9JFAvODB|IN88US=> NWfMNppvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1PVg3OzNpPkK4OVk5PjN|PD;hQi=>
K562 Mn;XR5l1d3SxeHnjbZR6KGG|c3H5 NFztV3M4OiCq NVLTdZdvUUN3MDC9JFAvODB5MjFOwG0> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV7OE[zN{c,Ojh3OUi2N|M9N2F-
MCF7 MUnDfZRwfG:6aXPpeJkh[XO|YYm= NI\Rdno4OiCq NH6wblVKSzVyIE2gNE4xODd|IN88US=> NYDVTmhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1PVg3OzNpPkK4OVk5PjN|PD;hQi=>
A2780 M3rQS2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGDN[|g1QCCq NGrLZ3VKSzVyIE2gNE4xODFyNzFOwG0> MmrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MkS3NFMoRjJ6NkK0O|A{RC:jPh?=
HeLa MlrHR5l1d3SxeHnjbZR6KGG|c3H5 NF7XNmU1QCCq M3XKS2lEPTBiPTCwMlAxOTFizszN NV7hN|gzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NlQ4ODNpPkK4OlI1PzB|PD;hQi=>
KB NFzScJJEgXSxdH;4bYNqfHliYYPzZZk> M2TRTlQ5KGh? NViwcJE6UUN3MDC9JFAvODBzOTFOwG0> NVPrdXhIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NlQ4ODNpPkK4OlI1PzB|PD;hQi=>
Hela-beta3 M{XzeGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn\ZOFghcA>? MmnGTWM2OCB;IECuNFA6KM7:TR?= MlPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MkS3NFMoRjJ6NkK0O|A{RC:jPh?=
A2780AD MmnFR5l1d3SxeHnjbZR6KGG|c3H5 M3XiTFQ5KGh? M2rsRmlEPTBiPTCxMlI5OiEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ{NEewN{c,Ojh4MkS3NFM9N2F-
KBV1 MVPDfZRwfG:6aXPpeJkh[XO|YYm= NIW5RoM1QCCq M3i3UWlEPTBiPTC5Mlgh|ryP MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ{NEewN{c,Ojh4MkS3NFM9N2F-
BGC823 NXezZYZLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn\NN{Bl[Xm| MVfJR|UxKD1iMD6wNFEh|ryP NV7kRYRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NlU{PjNpPkK4OlI2OzZ|PD;hQi=>
HepG2 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYqzJIRigXN? M1TYUmlEPTBiPTCwMlAzKM7:TR?= M3K4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkK1N|Y{Lz5{OE[yOVM3OzxxYU6=
HCT116 NVe2fopxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIDXV3A{KGSjeYO= NV\sW49mUUN3MDC9JFAvODNizszN MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ{NUO2N{c,Ojh4MkWzOlM9N2F-
A2780 NEXDSW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPM[5d{OyCmYYnz NWXD[4lmUUN3MDC9JFAvODNizszN M4TORVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkK1N|Y{Lz5{OE[yOVM3OzxxYU6=
NCI-H1650 MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2DkVVMh\GG7cx?= MnzXTWM2OCB;IECuNFch|ryP MlP4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MkWzOlMoRjJ6NkK1N|Y{RC:jPh?=
A2780 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M1\wcFIh\GG7cx?= NFfnPW9KSzVyIE2gNE4xOTN5IN88US=> MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ2OES5NUc,Ojh4NEi0PVE9N2F-
KB M{T1TWN6fG:2b4jpZ4l1gSCjc4PhfS=> NV7H[ohoPDhiaB?= MV;HTVUxKD1iMD6wNFUyOiEQvF2= NXXIbVdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVM5PDZpPkK4OlU{QDR4PD;hQi=>
A549 MkPuR5l1d3SxeHnjbZR6KGG|c3H5 NEfwO2k1QCCq MUPHTVUxKD1iMD6wNFcxOyEQvF2= NUT6UpRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVM5PDZpPkK4OlU{QDR4PD;hQi=>
MDA-MB-231 NGO1RY5EgXSxdH;4bYNqfHliYYPzZZk> M2nsO|Q5KGh? NWLxSpRYT0l3MDC9JFAvODFizszN NXPFT2JERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVM5PDZpPkK4OlU{QDR4PD;hQi=>
MCF7 NWLjT5g{S3m2b4TvfIlkcXS7IHHzd4F6 MofmOFghcA>? MUjHTVUxKD1iMD6wNVE6KM7:TR?= MoLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUO4OFYoRjJ6NkWzPFQ3RC:jPh?=
KBVIN MoD2R5l1d3SxeHnjbZR6KGG|c3H5 NUDVfoN{PDhiaB?= NFy1UZdIUTVyIE2gNk44OTZizszN NYTxPJAzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVM5PDZpPkK4OlU{QDR4PD;hQi=>
MCF7 MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NVjXdFFKPDhiaB?= M1zNV2lEPTBiPTCwMlAxQCEQvF2= NHvDT2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[1OFI2Pid-Mki2OVQzPTZ:L3G+
HL60 M37De2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Ml;xOFghcA>? MYnJR|UxKD1iMD6wNFgh|ryP M1XuNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkW0NlU3Lz5{OE[1OFI2PjxxYU6=
SMMC7721 NIj5O29CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml\HOFghcA>? NHLPTIFKSzVyIE2gNE4xODhizszN M3n2NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkW0NlU3Lz5{OE[1OFI2PjxxYU6=
A549 MmfvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M132dVQ5KGh? MWfJR|UxKD1iMD6wNFgh|ryP Mmn1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NUSyOVYoRjJ6NkW0NlU3RC:jPh?=
SW480 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mlr1OFghcA>? NEHzZXdKSzVyIE2gNE4xODhizszN NW\MZ2N{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OVQzPTZpPkK4OlU1OjV4PD;hQi=>
A375 MkTxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVj2[Hd3PDhiaB?= NVPpZZc2UUN3MDC9JFAvPyEQvF2= NIXiNpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[2O|g4Oid-Mki2Olc5PzJ:L3G+
MIAPaCa2 M3LuU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M1XpVlQ5KGh? MYPJR|UxKD1iMj61JO69VQ>? NGm1cYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[2O|g4Oid-Mki2Olc5PzJ:L3G+
HEY Mn\FR5l1d3SxeHnjbZR6KGG|c3H5 NXqwfJBoPDhiaB?= MnXRTWM2OCB;IECuNVA1OSEQvF2= NIO3XIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEexPVIxPCd-Mki3NVkzODR:L3G+
A2780 NFK1TYFEgXSxdH;4bYNqfHliYYPzZZk> MX20PEBp NG[3bo5KSzVyIE2gNE4yPjR{IN88US=> NHHUfVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEexPVIxPCd-Mki3NVkzODR:L3G+
HCT116 Mn3XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3LVU|k3KGh? NHzMNGpKSzVyIE2gNE4xODB{IN88US=> NWPH[FdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N|c{QTZpPkK4O|M4Ozl4PD;hQi=>
BGC823 NV;QWlh3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\tZXJZQTZiaB?= M17rXGlEPTBiPTCwMlAxODZizszN M1HFW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O3N|k3Lz5{OEezO|M6PjxxYU6=
HepG2 NV7wZ2tbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIrlPWE6PiCq MlTnTWM2OCB;IECuNFA4PiEQvF2= NVfLNpBZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N|c{QTZpPkK4O|M4Ozl4PD;hQi=>
A2780 M1\zNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVG5OkBp MUXJR|UxKD1iMD6wNlA1KM7:TR?= NGjsWVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEezO|M6Pid-Mki3N|c{QTZ:L3G+
A549 NGLudnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmTSOEBl[Xm| MYDHTVUxKD1iMD6wNFM4KM7:TR?= NVfle3o2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OFA3ODFpPkK4O|QxPjBzPD;hQi=>
PC3 M4nEbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXvtXI9UPCCmYYnz M1v1XGdKPTBiPTCwMlAxPThizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd2ME[wNUc,Ojh5NEC2NFE9N2F-
NCI-H460 NG\2XI9EgXSxdH;4bYNqfHliYYPzZZk> M33XVVczKGh? MXrJR|UxKD1iMD6wNFYh|ryP M36yWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{SwOlE{Lz5{OEe0NFYyOzxxYU6=
HT-29 NXTuTXJOS3m2b4TvfIlkcXS7IHHzd4F6 M321R|czKGh? MVzJR|UxKD1iMD6wNVQh|ryP MlP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5NEC2NVMoRjJ6N{SwOlE{RC:jPh?=
A2780S MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NEWzSHQ1QCCq M1PsXWlEPTBiPTCwMlAyOjNizszN MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd4M{[0Okc,Ojh5NkO2OFY9N2F-
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PC3-TxR MnXqR5l1d3SxeHnjbZR6KGG|c3H5 MoLWO|IhcA>? NYLtUFNNUUN3MDC9JFAvOTF|OTFOwG0> Mn3SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzMkKwN|UoRjNyMUKyNFM2RC:jPh?=
KB MlnLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NIXVOWg4OiCq Ml3NTWM2OCB;IEWuPUDPxE1? NILaV|E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG4PVM6Pid-M{CxPFk{QTZ:L3G+
A549 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{nwT|czKGh? MlK2TWM2OCB;IE[uPEDPxE1? MkLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzOEmzPVYoRjNyMUi5N|k3RC:jPh?=
MDA-MB-231 NHjFdotCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MV23NkBp M2no[WlEPTBiPTC5MlYh|ryP Mn7YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzOEmzPVYoRjNyMUi5N|k3RC:jPh?=
MDA-MB-231 NYfHZoliS3m2b4TvfIlkcXS7IHHzd4F6 NIrITWs4OiCq MnnOTWM2OCB;IECuNFAzPiEQvF2= Mn[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzOUK1N|coRjNyMUmyOVM4RC:jPh?=
MDA-MB-435 MorXR5l1d3SxeHnjbZR6KGG|c3H5 NHLVfm44OiCq M1nYUGlEPTBiPTCwMlAxOzFizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF7MkWzO{c,OzBzOUK1N|c9N2F-
OVCAR3 MXXDfZRwfG:6aXPpeJkh[XO|YYm= MWm3NkBp MlLITWM2OCB;IECuNFA4PSEQvF2= NHPXcnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG5NlU{Pyd-M{CxPVI2Ozd:L3G+
MV411 NVTLeoFFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3nhSVczKGh? M1Hyc2lEPTBiPTCwMlAyPyEQvF2= NGnaV2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKxNlE6QCd-M{CyNVIyQTh:L3G+
HGC27 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NX;kV|VxPzJiaB?= MVXJR|UxKD1iMD6wNlgh|ryP MkfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MUKxPVgoRjNyMkGyNVk5RC:jPh?=
HeLa NYXPU4NKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MnP4O|IhcA>? NV7uT2J{UUN3MDC9JFAvODR4IN88US=> NV;5eYlsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVIyQThpPkOwNlEzOTl6PD;hQi=>
A549 M4LYdGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NIL4TFQ4OiCq NHPWW3pKSzVyIE2gNE4xPTFizszN M2PBblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkGyNVk5Lz5|MEKxNlE6QDxxYU6=
HeLa NWfKfphRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NInhUXM1QCCq NEfUZZVKSzVyIE2gNE4xODJ6IN88US=> NV3FeVJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPVcyOThpPkOwNlk4OTF6PD;hQi=>
SKOV3 NXL2bFB1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NHzK[2o1QCCq NGrEeVBKSzVyIE2gNE4xODVizszN M4HBSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkm3NVE5Lz5|MEK5O|EyQDxxYU6=
SKOV3-MDR1-M6/6 NWfWeZdwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MV60PEBp NIXnSIRKSzVyIE2gNU4zKM7:TR?= NHHGRlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEK5O|EyQCd-M{CyPVcyOTh:L3G+
HCC1806 NXKzbYNISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVGyOEBp M{nJWmlEPTBiPTCwMlAxOSEQvF2= NH74fHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO5Nlk2Oyd-M{CzPVI6PTN:L3G+
BEAS2B MlHTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M2K4RlI1KGh? NXGxVGtiUUN3MDC9JFAvODB5IN88US=> NFnweYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO5Nlk2Oyd-M{CzPVI6PTN:L3G+
HT-29 NYnBb4FZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M2jmVlI1KGh? NGHt[3JKSzVyIE2gNE4xODhizszN NHvjUm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO5Nlk2Oyd-M{CzPVI6PTN:L3G+
HepG2 MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MW[yOEBp MmTwTWM2OCB;IECuNFA6KM7:TR?= NFP2WVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO5Nlk2Oyd-M{CzPVI6PTN:L3G+
PANC1 NHPtVXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NH\rdVIzPCCq NV;FOVdMUUN3MDC9JFAvODRizszN MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN7Mkm1N{c,OzB|OUK5OVM9N2F-
MDA-MB-231 NInxVmpEgXSxdH;4bYNqfHliYYPzZZk> MX20PEBp MlTOTWM2OCB;IECuNFA1KM7:TR?= NFjvS3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MESzN|c5Oyd-M{C0N|M4QDN:L3G+
A549 NITt[nJEgXSxdH;4bYNqfHliYYPzZZk> NGrnVIY1QCCq M3riN2lEPTBiPTCwMlAxPCEQvF2= NGTBTGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MESzN|c5Oyd-M{C0N|M4QDN:L3G+
PANC1 NUT0dHZOS3m2b4TvfIlkcXS7IHHzd4F6 NF30c|U1QCCq MYnJR|UxKD1iMD6wOkDPxE1? M{D3U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNEOzO|g{Lz5|MESzN|c5OzxxYU6=
4T1 NVjhVXFVS3m2b4TvfIlkcXS7IHHzd4F6 M2m5OFQ5KGh? NUKwXVd4UUN3MDC9JFAvODl2IN88US=> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODR|M{e4N{c,OzB2M{O3PFM9N2F-
A375 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MWe0PEBp NFTUZVdKSzVyIE2gNE4yKM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODR|M{e4N{c,OzB2M{O3PFM9N2F-
LLC M373SGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXi0PEBp M4fQSmlEPTBiPTCwMlE5QSEQvF2= Mkf3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB2M{O3PFMoRjNyNEOzO|g{RC:jPh?=
B16F10 NIjod|NEgXSxdH;4bYNqfHliYYPzZZk> NEm2PJI1QCCq MX3JR|UxKD1iMD61N{DPxE1? NUWxV5JkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C0N|M4QDNpPkOwOFM{Pzh|PD;hQi=>
B16F10 spheroid MVPDfZRwfG:6aXPpeJkh[XO|YYm= MoG3OFghcA>? M4fJWWlEPTBiPTC4MlAyKM7:TR?= NYjURm41RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C0N|M4QDNpPkOwOFM{Pzh|PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK; 

PubMed: 20068074     


Paclitaxel pulse induces phospho-ERK. Paclitaxel (6ug/mL) was pulsed over 10min to 4hr prior to cell harvesting. A biphasic activation is observed in the resistant cells.

MARCKS (pSer159/163); 

PubMed: 26015406     


Paclitaxel treatment induces activation of MARCKS and Src in TNBC cells. Cells were incubated with various doses of paclitaxel as indicated. After 24 hours, cells were collected and subjected to Western blot analysis.

Src (pTyr416); 

PubMed: 26015406     


Paclitaxel treatment induces activation of MARCKS and Src in TNBC cells. Cells were incubated with various doses of paclitaxel as indicated. After 24 hours, cells were collected and subjected to Western blot analysis.

p-JAK2 / p-STAT3 / p-AKT / p-MAPK / Bcl-xl / MCL-1; 

PubMed: 29849942     


OVCAR-8 and MDAH2774 cells were treated with ruxolitinib (20 μM), paclitaxel (10 nM) or the combination for 24 h. Whole cells were collected and determined for the change of STAT3, AKT and ERK pathways and expression of BCL-XL and MCL-1 by Western blot.

Id1; 

PubMed: 25344919     


(A) Paclitaxel suppressed Id1 expression in H520 cells in a time-dependent manner.

MARCKS; 

PubMed: 26015406     


Paclitaxel treatment induces activation of MARCKS and Src in TNBC cells. Cells were incubated with various doses of paclitaxel as indicated. After 24 hours, cells were collected and subjected to Western blot analysis.

20068074 26015406 29849942 25344919
Growth inhibition assay
Cell viability; 

PubMed: 28823711     


Paclitaxel reduces HeyA8 tumor cell viability in MTT assay.

28823711
Immunofluorescence
α-tubulin; 

PubMed: 22904633     


Cellular α-tubulin (red) was blotted by immunostaining and subsequent confocal microscopy 3 hours after A549 cells were treated with 12.5 nM of paclitaxel and 12.5 nM of PLGA-PEI-TAX, respectively. The same experiment was performed with 62.5 nM of paclitaxel and 62.5 nM of PLGA-PEI-TAX in A549/T12 cells. PLGA-PEI-TAX, poly(lactic-co-glycolic acid)-polyethylenimine nanoparticles loaded with paclitaxel.

Rab11a/BV9; 

PubMed: 29290815     


Paclitaxel reversed the DAVLBH-mediated inhibition of internalized VE-cadherin recycling back to the cell membrane. HUVECs pretreated with or without paclitaxel were treated with or without DAVLBH for 4 h. Quantification of BV9/Rab11a colocalization is shown (n = 3).

22904633 29290815
In vivo

The inhibition rations of Paclitaxel alone on BC-V and BC-ER tumors are 49.78% and 51.23%, respectively. Treatment of six cycles of 20 mg/kg Paclitaxel significantly reduces the percentages of Ki-67-positive cells to 20.4% in BC-V tumors and 25.1% in BC-ER tumors, respectively. [4]

Protocol

Cell Research:

[1]

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  • Cell lines: Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs
  • Concentrations: 0.1-100 pM
  • Incubation Time: 72 hours
  • Method:

    Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs), human mammary epithelial cells (HMEpCs), human prostate epithelial cells (PrEpCs) and human umbilical artery smooth muscle cells (UASMCs) are cultured. Cell proliferations are performed in 96-well plates using cells between passages 6 and 12. Cells are seeded at 3000–5000 cells/well and allowed to attach for 4 hours. Paclitaxel, diluted in culture medium, is added in quadruplicate wells and the cells ae incubated for 3 days before MTS reagents are added to quantitate the live cells in each well.


    (Only for Reference)
Animal Research:

[4]

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  • Animal Models: Female, 20-22 g homozygous nude athymic mice with BC-V and BC-ER tumors
  • Dosages: 20 mg/kg
  • Administration: Administered via i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 171 mg/mL (200.25 mM)
Water Insoluble
Ethanol ''18 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 853.91
Formula

C47H51NO14

CAS No. 33069-62-4
Storage powder
in solvent
Synonyms PTX, Taxol, Onxal, Abraxane
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04831320 Not yet recruiting Drug: nab-paclitaxel|Drug: Nivolumab Metastatic Head-and-neck Squamous-cell Carcinoma Washington University School of Medicine|Bristol-Myers Squibb July 31 2021 Phase 2
NCT04826016 Not yet recruiting Drug: POL6326|Drug: Eribulin|Drug: Nab paclitaxel Advanced Breast Cancer MedSIR July 2021 Phase 1|Phase 2
NCT04835896 Not yet recruiting Drug: M7824+paclitaxel Recurrent/Metastatic Gastric Cancer Yonsei University May 1 2021 Phase 1|Phase 2
NCT04865250 Recruiting Drug: Atezolizumab NSCLC Stage II|NSCLC Stage IIIA|NSCLC Stage IIIB University Hospital Heidelberg|Roche Pharma AG January 7 2021 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I am interested in the product S1150 for in vivo studies, could you please give some suggestions for the formulation?

  • Answer:

    S1150 in 1% DMSO+30% polyethylene glycol+1% Tween 80 at 30mg/ml is a suspension. If the you want to inject it, there is another vehicle, 5% DMSO+5% Tween 80+ddH2O. S1150 can dissolve in it at 2.5mg/ml as a clear solution. It is a common formulation we used, but is not cited from reference.

  • Question 2:

    the compound was dissolved into 1ml DMSO and diluted with 1x PBS or water (500ul + 9.5 ml PBS or water). I found the white precipitation goes out. How to figure it out?

  • Answer:

    Paclitaxel has very low solubility in water based solution and that's why it precipitated out once you dilute the stock with water. The vehicle we suggest is: 1% DMSO+30% polyethylene glycol+1% Tween 80.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID