Paclitaxel (NSC 125973)

Catalog No.S1150 Synonyms: PTX, Taxol, Onxal, Abraxane

For research use only.

Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

Paclitaxel (NSC 125973) Chemical Structure

CAS No. 33069-62-4

Selleck's Paclitaxel (NSC 125973) has been cited by 304 publications

Purity & Quality Control

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Paclitaxel (NSC 125973, PTX, Taxol, Onxal, Abraxane) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Targets
Microtubule (human endothelial cells) [1]
0.1 pM
In vitro

Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM. The selectivity of Paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to Paclitaxel at ultra low concentrations. Inhibition of human ECs by Paclitaxel at ultra low concentrations does not affect the cellular microtubule structure, and the treated cells do not show G2/M cell cycle arrest and apoptosis, suggesting a novel but as yet unidentified mechanism of action. In an in vitro angiogenesis assay, Paclitaxel at ultra low concentrations blocks human ECs from forming sprouts and tubes in the three-dimensional fibrin matrix. [1] In the presence of SMF, the efficient concentration of Paclitaxel on K562 cells is decreased from 50 to 10 ng/mL. The cell cycle arrest effect of Paclitaxel with or without SMF on K562 cells is correlated with DNA damage. [2] Paclitaxel alone causes a time-dependent inhibition of CDK1 in four cell lines including A549 cells, H358, H1395 cells and H1666 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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SK-MEL-2 MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fnXWlEPTBiPTC4MlQ2QTd4IN88US=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
COLO-800 MnHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxKD1iOD60O|g4KM7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
EB2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxKD1iOT6xPVg{PSEQvF2= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
ES3 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxKD1iOT6zNFY3PSEQvF2= NXWwXFk3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
SKM-1 NF\0fXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHDTWM2OCB;IEmuN|k1PTlizszN MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
MFM-223 NIS3fGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxKD1iOT61NFEzPyEQvF2= MmXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
LB2241-RCC MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TVfGlEPTBiPTCxNE4xOzh4IN88US=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
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D-283MED MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PtWmlEPTBiPTCxNE41QTV7IN88US=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
EW-11 MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXSWlJKSzVyIE2gNVEvPjZ7NDFOwG0> M1TmRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
NCI-H128 M3:zSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fQfGlEPTBiPTCxNk4yOzN2IN88US=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
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AM-38 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxKD1iMUWuOFE3PiEQvF2= NFz5fpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
NCI-H716 NWXUU5pMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxKD1iMUeuPVI6QSEQvF2= MnrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
NCI-H1770 NUfFVXhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxKD1iMUiuN|g2OSEQvF2= MkLYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
JVM-3 NILtb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfSV4lKSzVyIE2gNlAvQDl6NTFOwG0> M3HVeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
CW-2 NITQbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITi[G5KSzVyIE2gNlEvOTN2OTFOwG0> M{PPVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
YT NGDl[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfzTWM2OCB;IEKxMlQ3QTFizszN MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
C8166 M1zKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\oNGxKSzVyIE2gNlIvOjd2NjFOwG0> M4\UV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
SUP-T1 NX73O5d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ncIlKSzVyIE2gNlMvOjVzMjFOwG0> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0Nlg3PDdxJ{7TRW5ITVJ:L3G+
KASUMI-1 M3;qS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT5Z5JKSzVyIE2gNlMvPTFzOTFOwG0> M4[5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQDZ2Nz:nQnNCVkeHUkyvZV4>
IM-9 NEXubpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILsNZZKSzVyIE2gNlMvPjl5OTFOwG0> NVPZU|U3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
NH-12 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxKD1iMkSuNVY2PCEQvF2= NH7B[mc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
WSU-NHL MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxKD1iMkWuO|I3OSEQvF2= NH65R449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
TUR NHHu[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zhdGlEPTBiPTCyOk43PTN|IN88US=> NF7ZeZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
RL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojjTWM2OCB;IEK3MlIzPDJizszN MnnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
EW-12 NVezcoFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XhV2lEPTBiPTCyPE4xPzB{IN88US=> NYPqTo5RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
KG-1 NVvGUnJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxKD1iMkiuNlg3PSEQvF2= NYLONlhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ6NkS3M{c,W0GQR1XSQE9iRg>?
P31-FUJ MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxKD1iMkmuNFQ5QSEQvF2= MkPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI5PjR5Lze+V2FPT0WUPD;hQi=>
NB10 NXvSOllGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXTOGpKSzVyIE2gN|EvPTB7IN88US=> NISzNFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojh4NEevK|5USU6JRWK8M4E,
COLO205 M{TZ[2N6fG:2b4jpZ4l1gSCjc4PhfS=> M2fPe2dKPTBiPTCwMlAxOTd4IN88US=> MmXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzlyOEm1NEc,PzlyOEm1NFww[T5?
SF539 NXjC[405S3m2b4TvfIlkcXS7IHHzd4F6 MUTHTVUxKD1iMD6wNFM3PiEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
SNB75 MojIR5l1d3SxeHnjbZR6KGG|c3H5 M{LTT2dKPTBiPTCwMlAxQDB6IN88US=> MnrRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwPzlyOEm1NEc,PzlyOEm1NFww[T5?
DMS114 MmroR5l1d3SxeHnjbZR6KGG|c3H5 MnfLS2k2OCB;IECuNFEzOyEQvF2= NHzNcow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95OUC4PVUxLz55OUC4PVUxRC:jPh?=
OVCAR-3 M2S5eWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXzkR3FYT0l3MDC9JFAvODF7NzFOwG0> NXKxZpplRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{mwPFk2OCd-N{mwPFk2ODxxYU6=
NCI-H460 MlzPR5l1d3SxeHnjbZR6KGG|c3H5 NWTzcWxGT0l3MDC9JFAvODJzOTFOwG0> M2TBdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd7MEi5OVAoRjd7MEi5OVA9N2F-
HOP62 MlHLR5l1d3SxeHnjbZR6KGG|c3H5 MVLHTVUxKD1iMD6wOlcyKM7:TR?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84QTB6OUWwK|44QTB6OUWwQE9iRg>?
mammary carcinoma NXHPboJiS3m2b4TvfIlkcXS7IHHzd4F6 MkDaTWM2OCB;IECuNlk6KM7:TR?= MnHKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQDF6Mk[5PEc,QDF6Mk[5PFww[T5?
NCI60 MYnDfZRwfG:6aXPpeJkh[XO|YYm= M4izNmdKPTBiPTCwMlAxODZ3IN88US=> NVP1WotKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUS2NVY2Oyd-OUS2NVY2OzxxYU6=
MCF-7 NIrtZnlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFm5e|hIUTVyIE2gNE4xODFzIN88US=> MkPSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5M{W5O{c,QTh5M{W5O|ww[T5?
murine leukemic P388 M2XUZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoDaS2k2OCB;IECuNFE3KM7:TR?= NETHXGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEezOVk4Lz57OEezOVk4RC:jPh?=
KB MULDfZRwfG:6aXPpeJkh[XO|YYm= MnO2TWM2OCB;IECuNFA3KM7:TR?= M3PEeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyOUe4NlAxLz5zMEm3PFIxODxxYU6=
MCF7 MmfPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Ml[2O|IhcA>? M1XCXmlEPTBiPTCwMlAxOiEQvF2= NXm0eoRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzNlUzOjZpPkGxN|I2OjJ4PD;hQi=>
MCF-7 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NF65R4dGTDVyIE2gNE4xODRizszN NWrWRVJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUGzN|Q2PjdpPkGxN|M1PTZ5PD;hQi=>
uterine sarcoma (MES-SA) MnnXR5l1d3SxeHnjbZR6KGG|c3H5 NVi0cnQ4UUN3MDC9JFAvODByMESg{txO MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd{OEG5NUc,OTF5MkixPVE9N2F-
nonsmall cell lung carcinoma (NCI-H460) MXHDfZRwfG:6aXPpeJkh[XO|YYm= NEK5[mJKSzVyIE2gNE4xODBzNDFOwG0> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd{OEG5NUc,OTF5MkixPVE9N2F-
colon adenocarcinoma (HT-29) NWrobmVzS3m2b4TvfIlkcXS7IHHzd4F6 M3KzUmlEPTBiPTCwMlAxODF4IN88US=> NWfUZ|BjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3NlgyQTFpPkGxO|I5OTlzPD;hQi=>
prostate carcinoma (DU-145) M33UfWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWLvVlJnUUN3MDC9JFAvODB2OEmg{txO M2TPfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{K4NVkyLz5zMUeyPFE6OTxxYU6=
SW626 NGfTVJVEgXSxdH;4bYNqfHliYYPzZZk> Mlz1O|IhcA>? M3nHVWlEPTBiPTCwMlAxODBzIN88US=> NGjhVGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
Lu1 MVrDfZRwfG:6aXPpeJkh[XO|YYm= NYHBRmVrPzJiaB?= NH7Le2pKSzVyIE2gNE4xOSEQvF2= NHLGbpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
MCF7 MWLDfZRwfG:6aXPpeJkh[XO|YYm= M3;0bFczKGh? MVXJR|UxKD1iMD6wNkDPxE1? M3fqU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
P388 NF3FTJJEgXSxdH;4bYNqfHliYYPzZZk> M4Sw[|czKGh? NFzvXmpKSzVyIE2gNE4xOiEQvF2= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
LNCAP NFfRNHhEgXSxdH;4bYNqfHliYYPzZZk> NX;UOldVPzJiaB?= NHPTPXBKSzVyIE2gNE4xOiEQvF2= M2C5SVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
KB MlrlR5l1d3SxeHnjbZR6KGG|c3H5 MVG3NkBp M4\YS2lEPTBiPTCwMlAzKM7:TR?= MmfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJyOEi0NlUoRjF{MEi4OFI2RC:jPh?=
Col2 MXLDfZRwfG:6aXPpeJkh[XO|YYm= NEnrdlc4OiCq NWO0XIhKUUN3MDC9JFAvODJizszN MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjB6OESyOUc,OTJyOEi0NlU9N2F-
BC1 NUjzS241S3m2b4TvfIlkcXS7IHHzd4F6 M1njc|czKGh? MkXKTWM2OCB;IECuNFIh|ryP NGSxdJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC4PFQzPSd-MUKwPFg1OjV:L3G+
SK-MEL-2 NULNN3Z5S3m2b4TvfIlkcXS7IHHzd4F6 Mn[zO|IhcA>? MlLPTWM2OCB;IECuNFch|ryP M3rsSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MEi4OFI2Lz5zMkC4PFQzPTxxYU6=
L2987 NWXPcplmS3m2b4TvfIlkcXS7IHHzd4F6 NFv2XmdKSzVyIE2gNE4zKM7:TR?= MonIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ2NEO3PFMoRjF{NESzO|g{RC:jPh?=
colon adenocarcinoma RKO NYTmcnhWS3m2b4TvfIlkcXS7IHHzd4F6 MojPTWM2OCB;IECuNFEh|ryP M2q0WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OEWyO|Y5Lz5zMki1Nlc3QDxxYU6=
NCI-H460 NHzrTVVEgXSxdH;4bYNqfHliYYPzZZk> M1q5UFQ5KGh? NHfpR|lKSzVyIE2gNE4xODl3IN88US=> MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDZ7NUe5PEc,OTR4OUW3PVg9N2F-
MCF7 NHTaPYZEgXSxdH;4bYNqfHliYYPzZZk> MmH1OFghcA>? NGDj[YJKSzVyIE2gNE4xOTF{IN88US=> NIO3UmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNE[5OVc6QCd-MUS2PVU4QTh:L3G+
SF268 NWrjOWZkS3m2b4TvfIlkcXS7IHHzd4F6 MoDmOFghcA>? M{S1fmlEPTBiPTCwMlAzOTdizszN M1LNUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2Nkm1O|k5Lz5zNE[5OVc6QDxxYU6=
MDA-MB-231 M{fEZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoDuOFghcA>? MWPJR|UxKD1iMD6wNFQ2KM7:TR?= M4jEVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF2OUi3NFUyLz5zNEm4O|A2OTxxYU6=
MCF7 MnXsR5l1d3SxeHnjbZR6KGG|c3H5 M2nOXlQ5KGh? MlvtTWM2OCB;IECuNFA1QSEQvF2= NVTPfmR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTFpPkG0PVg4ODVzPD;hQi=>
A2780 NGfhRZlEgXSxdH;4bYNqfHliYYPzZZk> M3nxZVQ5KGh? NH\NdJJKSzVyIE2gNE4xOjVizszN MnexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR7OEewOVEoRjF2OUi3NFUyRC:jPh?=
PC3 MmrvR5l1d3SxeHnjbZR6KGG|c3H5 MW[0PEBp MmDxTWM2OCB;IECuNFc4KM7:TR?= NUjBRlFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUS5PFcxPTFpPkG0PVg4ODVzPD;hQi=>
MCF7 M3KwVGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGrwfXY4OiCq M{KyRmlEPTBiPTCwMlAxOTRizszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDl6N{C1Okc,OTR7OEewOVY9N2F-
multidrug-resistant MCF7 NXfsZms1S3m2b4TvfIlkcXS7IHHzd4F6 M{LtUFczKGh? NIm5bJhKSzVyIE2gNE4{PTRizszN NEfHSnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEm4O|A2Pid-MUS5PFcxPTZ:L3G+
PC3 MW\DfZRwfG:6aXPpeJkh[XO|YYm= M1vadlQ5KGh? M4PpZWlEPTBiPTCwMlAyPiEQvF2= MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFIoRjF3MESzOFAzRC:jPh?=
Hep3B NGrQPXdEgXSxdH;4bYNqfHliYYPzZZk> M1PVXlQ5KGh? MVTJR|UxKD1iMD6wN|Eh|ryP Mo\LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFIoRjF3MESzOFAzRC:jPh?=
NCI-H460 MUDDfZRwfG:6aXPpeJkh[XO|YYm= NGnL[mk1QCCq MUTJR|UxKD1iMD6wNFk2KM7:TR?= NH3RSlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPCd-MUWwOFM1ODR:L3G+
MCF7 NIXlWnZEgXSxdH;4bYNqfHliYYPzZZk> NIjoOJc1QCCq NU\COJRMUUN3MDC9JFAvODFzMjFOwG0> NYPEWoxzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODRpPkG1NFQ{PDB2PD;hQi=>
SF268 MnXjR5l1d3SxeHnjbZR6KGG|c3H5 M{m0clQ5KGh? M165VmlEPTBiPTCwMlAzOTdizszN MmTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFQoRjF3MESzOFA1RC:jPh?=
KB MVHDfZRwfG:6aXPpeJkh[XO|YYm= MXfFSFUxKD1iMD6wNFA1KM7:TR?= NGDxeFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
Lu1 NGnKcFlEgXSxdH;4bYNqfHliYYPzZZk> Ml7KSWQ2OCB;IECuNFAzKM7:TR?= NXfmNJY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWwOFM1ODdpPkG1NFQ{PDB5PD;hQi=>
LNCAP NHXUOYREgXSxdH;4bYNqfHliYYPzZZk> MYTFSFUxKD1iMD6wNFUh|ryP MnroQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTVyNEO0NFcoRjF3MESzOFA4RC:jPh?=
RPE1 MnnyR5l1d3SxeHnjbZR6KGG|c3H5 MknzSWQ2OCB;IECuNFI{KM7:TR?= M3\HN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MESzOFA4Lz5zNUC0N|QxPzxxYU6=
Col2 MV3DfZRwfG:6aXPpeJkh[XO|YYm= NFTDeWZGTDVyIE2gNE4xPDZizszN NHrB[249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUC0N|QxPyd-MUWwOFM1ODd:L3G+
T47D MV3BdI9xfG:|aYOgZZN{[Xl? NVvTXIE{OjRiaB?= M{nlUmVEPTBiPTCwMlA{KM7:TR?= M1rNeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NU[2N|AxLz5zNUW2OlMxODxxYU6=
DLD1 MlizRZBweHSxc3nzJIF{e2G7 MmO5NlQhcA>? NGn5fJVGSzVyIE2gNE4xPzVizszN MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkOwNEc,OTV3Nk[zNFA9N2F-
H1299 MmDRRZBweHSxc3nzJIF{e2G7 NUnHbnFUOjRiaB?= MVXFR|UxKD1iMD6xOlMh|ryP MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV4NkOwNEc,OTV3Nk[zNFA9N2F-
VA13 M13WVGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUT6XJJ6PDhiaB?= MWPJR|UxKD1iMD6wNFUh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTd|MEK0N{c,OTV5M{CyOFM9N2F-
WI 38 M1SwdGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUn0XGhuPDhiaB?= MnqzTWM2OCB;IECuNFQh|ryP NVfOOFdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3N|AzPDNpPkG1O|MxOjR|PD;hQi=>
Hep G2 MkLNR5l1d3SxeHnjbZR6KGG|c3H5 NHPTSZo1QCCq NUCwXIpLUUN3MDC9JFgvOSEQvF2= NVzvOYRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3N|AzPDNpPkG1O|MxOjR|PD;hQi=>
A549 MXnDfZRwfG:6aXPpeJkh[XO|YYm= NIHUXYU1QCCq NU\zSWZiUUN3MDC9JFEvOjVizszN MlKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV5OEe0OlAoRjF3N{i3OFYxRC:jPh?=
SKOV3 NHzhSWxEgXSxdH;4bYNqfHliYYPzZZk> MoXoOFghcA>? MWjJR|UxKD1iMT6zOUDPxE1? M4fZRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{i3OFYxLz5zNUe4O|Q3ODxxYU6=
KB Mk\CR5l1d3SxeHnjbZR6KGG|c3H5 M{fhSVMh\GG7cx?= NGLDWpFKSzVyIE2gNE4xODFizszN M4\uOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4MEO4OVQ2Lz5zNkCzPFU1PTxxYU6=
1A9 M2\EVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M{\UU|Mh\GG7cx?= MX3JR|UxKD1iMD6wNFIh|ryP NXnUbnY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[wN|g2PDVpPkG2NFM5PTR3PD;hQi=>
HCT8 M1Gzd2N6fG:2b4jpZ4l1gSCjc4PhfS=> MV2zJIRigXN? NYK2O5E3UUN3MDC9JFAvODF|IN88US=> NIS2S3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkCzPFU1PSd-MU[wN|g2PDV:L3G+
A431 NX\TSYhzS2WubDDjfYNt\SCjcoLld5Qh[XO|YYm= M3rIT2VEPTBiPTCwMlAxQSEQvF2= M4frT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{e3NVg4Lz5zNkO3O|E5PzxxYU6=
VA13 NXu4UYJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2WxZlQ5KGh? M1TCfmlEPTBiPTCwMlAxPDNizszN Mo\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2OUmzNlIoRjF4NEm5N|IzRC:jPh?=
WI38 NGPvT2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXy0PEBp NELENIVKSzVyIE2gNE4xOzRizszN MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjR7OUOyNkc,OTZ2OUmzNlI9N2F-
HepG2 M3\PVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWW0PEBp MlHVTWM2OCB;IE[uPUDPxE1? M1vSXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEm5N|IzLz5zNkS5PVMzOjxxYU6=
Aro NWHCZ|NQS3m2b4TvfIlkcXS7IHHzd4F6 M3KzO2lEPTBiPTCwMlAxODJizszN MoPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
PT45 NVnT[JQxS3m2b4TvfIlkcXS7IHHzd4F6 Mle5TWM2OCB;IECuNFA2KM7:TR?= NIjNV289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
A549 MWrDfZRwfG:6aXPpeJkh[XO|YYm= MmDITWM2OCB;IECuNFA3KM7:TR?= M4PHUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
MCF7 NICzXopEgXSxdH;4bYNqfHliYYPzZZk> NVnmT5p[UUN3MDC9JFAvODB5IN88US=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
HeLa MUDDfZRwfG:6aXPpeJkh[XO|YYm= M4rLdGlEPTBiPTCwMlAxQCEQvF2= M{DUeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NUO5N|c4Lz5zNkWzPVM4PzxxYU6=
Ovcar3 NHTsSFFEgXSxdH;4bYNqfHliYYPzZZk> M2L0e2lEPTBiPTCwMlAyKM7:TR?= MlvJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
HT29 MUHDfZRwfG:6aXPpeJkh[XO|YYm= MYDJR|UxKD1iMD6wOUDPxE1? NHvHdJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
H295R MXnDfZRwfG:6aXPpeJkh[XO|YYm= MmH5TWM2OCB;IECuNFgh|ryP MkTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
BNL M17CSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NX3tWVRUUUN3MDC9JFAvOiEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV|OUO3O{c,OTZ3M{mzO|c9N2F-
4T1 NEPsU4lEgXSxdH;4bYNqfHliYYPzZZk> MlvCTWM2OCB;IECuNkDPxE1? NEfi[4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkWzPVM4Pyd-MU[1N|k{Pzd:L3G+
HepG2 NFjhUphEgXSxdH;4bYNqfHliYYPzZZk> M2XM[mlEPTBiPTCwMlMh|ryP MlLRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ3M{mzO|coRjF4NUO5N|c4RC:jPh?=
U937 GTB NYS1eYg4S3m2b4TvfIlkcXS7IHHzd4F6 MVu3NkBp Ml\vTWM2OCB;IECuNFA2QSEQvF2= MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjV4Mki0NEc,OTZ3NkK4OFA9N2F-
RPMI 8226/s MX3DfZRwfG:6aXPpeJkh[XO|YYm= MXe3NkBp NFTvTpBKSzVyIE2gNE4xODdizszN M3P3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFQxLz5zNkW2Nlg1ODxxYU6=
CEM/s M3fZOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUW3NkBp NFuwSXpKSzVyIE2gNE4xODdizszN M2LmblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NU[yPFQxLz5zNkW2Nlg1ODxxYU6=
VA13 Mo\JR5l1d3SxeHnjbZR6KGG|c3H5 M13CNmlEPTBiPTCwMlAxPTlizszN NHzz[Zo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkeyOFg1Oid-MU[3NlQ5PDJ:L3G+
WI38 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MXzJR|UxKD1iMD6wOFY5KM7:TR?= NW\OTnpNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3NlQ5PDJpPkG2O|I1QDR{PD;hQi=>
HepG2 NHKxeIxEgXSxdH;4bYNqfHliYYPzZZk> MXrJR|UxKD1iOT60PUDPxE1? Mnz1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5MkS4OFIoRjF4N{K0PFQzRC:jPh?=
HT29 NIOxUnpEgXSxdH;4bYNqfHliYYPzZZk> MV3FR|UxKD1iMD6wNFYh|ryP NXvtS|EyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[4O|A1OjhpPkG2PFcxPDJ6PD;hQi=>
K562 M1S4UmN6fG:2b4jpZ4l1gSCjc4PhfS=> Ml\BSWM2OCB;IECuNFE1KM7:TR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjh5MESyPEc,OTZ6N{C0Nlg9N2F-
MCF7 M3fnPWN6fG:2b4jpZ4l1gSCjc4PhfS=> M12zeGVEPTBiPTCwMlA{PiEQvF2= M{HoXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OEewOFI5Lz5zNki3NFQzQDxxYU6=
VA-13 MlvxR5l1d3SxeHnjbZR6KGG|c3H5 M{PPUGlEPTBiPTCwMlAxPSEQvF2= M3S2VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUOzPFY5Lz5zNkmzN|g3QDxxYU6=
WI38 M1vGZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> MU\JR|UxKD1iMD6wOEDPxE1? M{PIUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUOzPFY5Lz5zNkmzN|g3QDxxYU6=
VA13 MmXRR5l1d3SxeHnjbZR6KGG|c3H5 MVzJR|UxKD1iMD6wNFUh|ryP MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB4N{G1OUc,OTdyNkexOVU9N2F-
WI38 MXLDfZRwfG:6aXPpeJkh[XO|YYm= MX3JR|UxKD1iMD6wOEDPxE1? M{PDRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5ME[3NVU2Lz5zN{C2O|E2PTxxYU6=
Hep G2 MnHKR5l1d3SxeHnjbZR6KGG|c3H5 NH7t[WdKSzVyIE2gPE4yKM7:TR?= NH2zfFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C2O|E2PSd-MUewOlcyPTV:L3G+
TW01 NX2yc29{S3m2b4TvfIlkcXS7IHHzd4F6 M1XqUWlEPTBiPTCwMlAxODNizszN NHLUTHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
MCF7 NIW0eWFEgXSxdH;4bYNqfHliYYPzZZk> MlK0TWM2OCB;IECuNFAxPSEQvF2= NXjtVWpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
MKN45 M2ezeGN6fG:2b4jpZ4l1gSCjc4PhfS=> MlzzTWM2OCB;IECuNFAxPSEQvF2= NYX4Zpp[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
MES-SA NHfxTZlEgXSxdH;4bYNqfHliYYPzZZk> NYm1Z3JKUUN3MDC9JFAvODByNTFOwG0> Mn3WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzMUOyPFgoRjF5MUGzNlg5RC:jPh?=
HCT116 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MlW3TWM2OCB;IECuNFAxPiEQvF2= NGPpeI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
RPTEC NYLGPYg3S3m2b4TvfIlkcXS7IHHzd4F6 MV7JR|UxKD1iMD6wNFA6KM7:TR?= NFTQUWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GxN|I5QCd-MUexNVMzQDh:L3G+
Hep3B MUjDfZRwfG:6aXPpeJkh[XO|YYm= NW\Ze|F4UUN3MDC9JFAvODB3NDFOwG0> NUHkZVU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
NCI-H226 M{HtSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGm4e41KSzVyIE2gNE4xODZ6IN88US=> NUjqXJhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNVMzQDhpPkG3NVE{Ojh6PD;hQi=>
A498 NXrHXIJOS3m2b4TvfIlkcXS7IHHzd4F6 NYW5cZVSUUN3MDC9JFAvODZzIN88US=> M{nXRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUGzNlg5Lz5zN{GxN|I5QDxxYU6=
MDA435/LCC6 Mk\NRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NFznOVRKSzVyIE2gNE4xODJ7IN88US=> MnTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNUS1NFUoRjF5MUW0OVA2RC:jPh?=
multidrug resistant MDA435/LCC6 NX;3R2V7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXLaTXplUUN3MDC9JFAvODB2ODFOwG0> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
P388 NIPMTXdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2PmOGlEPTBiPTCwMlAzOiEQvF2= NInMUVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G1OFUxPSd-MUexOVQ2ODV:L3G+
adriamycin resistant P388 NIXjTpZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NGLKU2NKSzVyIE2gNE4xOyEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
LT12 NXvoTlNPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1fEdlQ5KGh? MoHBTWM2OCB;IECuNFA3KM7:TR?= NEHEfJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
SKOV3 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Mon6OFghcA>? NVHwTmh{UUN3MDC9JFAvODFizszN MnjVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
NCI-H460 M4DRXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlX3OFghcA>? M{n3cGlEPTBiPTCwMlAyKM7:TR?= Mn[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
SF268 MkWzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MVm0PEBp NInnUVhKSzVyIE2gNE4xOSEQvF2= M{j5c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
RKO M4nmRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYLDW295PDhiaB?= M172XWlEPTBiPTCwMlAyKM7:TR?= M4\FPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVY1Lz5zN{G4NVE3PDxxYU6=
KB/HeLa MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MnWzOFghcA>? NU\oU|ZyUUN3MDC9JFAvODFizszN NYDYNlZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPjRpPkG3NVgyOTZ2PD;hQi=>
P388 MonrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MUG0PEBp MkHBTWM2OCB;IECuNFQh|ryP NFvFdVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE3PCd-MUexPFEyPjR:L3G+
L1210 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NFrzdWo1QCCq M4i4T2lEPTBiPTCwMlA3KM7:TR?= MmLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
LT12 MDR NFTsXIxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHLZXYM1QCCq NXjQemFMUUN3MDC9JFAvPCEQvF2= MmDkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOlQoRjF5MUixNVY1RC:jPh?=
A2780 M1i5UWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUH6XI5YUUN3MDC9JFAvODBzIN88US=> NGrGdpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KwOlE{QSd-MUeyNFYyOzl:L3G+
A2780-1A9 NVG0clE5S3m2b4TvfIlkcXS7IHHzd4F6 M4\rOmlEPTBiPTCwMlAxOTFizszN MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
A549 NFnDPHlEgXSxdH;4bYNqfHliYYPzZZk> M4e5e2lEPTBiPTCwMlAxOzZizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJyNkGzPUc,OTd{ME[xN|k9N2F-
1A9PTX22 MkT3R5l1d3SxeHnjbZR6KGG|c3H5 M3fs[2lEPTBiPTCwMlAyQSEQvF2= M2XDZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
1A9PTX10 NF7kUmVEgXSxdH;4bYNqfHliYYPzZZk> MWTJR|UxKD1iMD6wN{DPxE1? NGD4c3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{KwOlE{QSd-MUeyNFYyOzl:L3G+
A2780AD NULFb|JMS3m2b4TvfIlkcXS7IHHzd4F6 NVK4N2p4UUN3MDC9JFAvQSEQvF2= M4XEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkC2NVM6Lz5zN{KwOlE{QTxxYU6=
KB MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MXfJR|UxKD1iMD6wNFI1PSEQvF2= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ{OEi3N{c,OTd{Mki4O|M9N2F-
COLO205 MVnDfZRwfG:6aXPpeJkh[XO|YYm= MnTSTWM2OCB;IECuNFA{OyEQvF2= M{XCNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkK4PFc{Lz5zN{KyPFg4OzxxYU6=
KB8.5 M1zzcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MkjkTWM2OCB;IECuNFI3KM7:TR?= NVfzdW5WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyNlg5PzNpPkG3NlI5QDd|PD;hQi=>
KBV1 M3KybWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2fZZmlEPTBiPTCyMlAyOyEQvF2= MkfFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{Mki4O|MoRjF5MkK4PFc{RC:jPh?=
A2780 NVPoUZhbS3m2b4TvfIlkcXS7IHHzd4F6 NH7jeZBKSzVyIE2gNE4xODB5IN88US=> Ml7IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{M{m1PVcoRjF5MkO5OVk4RC:jPh?=
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1A9 NGn4bIdEgXSxdH;4bYNqfHliYYPzZZk> NGXQOWRGTDVyIE2gNE4xODFizszN NWfs[HlTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOVA5OzRpPkG3N|UxQDN2PD;hQi=>
MCF7 NWXyWmFKS3m2b4TvfIlkcXS7IHHzd4F6 MYjFSFUxKD1iMD6wNFEyKM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
DU145 MVrDfZRwfG:6aXPpeJkh[XO|YYm= NXTHVWhrTUR3MDC9JFAvODBzMzFOwG0> NGjobG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O1NFg{PCd-MUezOVA5OzR:L3G+
KB MlT5R5l1d3SxeHnjbZR6KGG|c3H5 MmjLSWQ2OCB;IECuNFAyQCEQvF2= NWnFS403RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOVA5OzRpPkG3N|UxQDN2PD;hQi=>
A549 NXzaUG9mS3m2b4TvfIlkcXS7IHHzd4F6 MY\FSFUxKD1iMD6wNFI{KM7:TR?= M4P6TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
LNCAP MWjDfZRwfG:6aXPpeJkh[XO|YYm= NUDpPHltTUR3MDC9JFAvODB{NjFOwG0> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN3MEizOEc,OTd|NUC4N|Q9N2F-
PC3 NVzxXHlOS3m2b4TvfIlkcXS7IHHzd4F6 NHzo[JpGTDVyIE2gNE4xPTV3IN88US=> M{DJZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{WwPFM1Lz5zN{O1NFg{PDxxYU6=
KBVIN NIfhU4VEgXSxdH;4bYNqfHliYYPzZZk> NXPpe4pbTUR3MDC9JFAvOzFzIN88US=> NYLHPIJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezOVA5OzRpPkG3N|UxQDN2PD;hQi=>
A2780 MVnDfZRwfG:6aXPpeJkh[XO|YYm= Moq0TWM2OCB;IECuNFAyPiEQvF2= NXz2e3ZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezPVU1PjVpPkG3N|k2PDZ3PD;hQi=>
A2780/AD MX\DfZRwfG:6aXPpeJkh[XO|YYm= NVLac4l1UUN3MDC9JFAvQTJizszN NHroN4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O5OVQ3PSd-MUezPVU1PjV:L3G+
KB M3jHUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGnGTnFKSzVyIE2gNE4xODJ2NTFOwG0> M4XmUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
COLO205 Ml\PR5l1d3SxeHnjbZR6KGG|c3H5 M3TaVGlEPTBiPTCwMlAxOzNizszN MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KB8.5 NX\h[Zc6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEXqPXdKSzVyIE2gNE4xOjZizszN MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzNkWyOEc,OTd2MU[1NlQ9N2F-
KBV1 MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVPJR|UxKD1iMj6wNVMh|ryP M3HPdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG2OVI1Lz5zN{SxOlUzPDxxYU6=
neural precursor MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWn4cZU{TUN3MDC9JFAvODFizszN M4O2Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
OVCAR-3 MmXQR5l1d3SxeHnjbZR6KGG|c3H5 NGHKSlNKSzVyIE2gNE4xODB{IN88US=> MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOUC2OUc,OTd2MUmwOlU9N2F-
MDA-MB-231 MUnDfZRwfG:6aXPpeJkh[XO|YYm= MUDJR|UxKD1iMD6wNFQ2KM7:TR?= NYL2cJlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
MCF7 MmLXR5l1d3SxeHnjbZR6KGG|c3H5 NX7wSHY2UUN3MDC9JFAvODB2OTFOwG0> M1fBVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
NCI-H1299 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MnvDPVYhcA>? MYDJR|UxKD1iMD6wNVUh|ryP Mle3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
A2780 NXj2O4xRS3m2b4TvfIlkcXS7IHHzd4F6 MYrJR|UxKD1iMD6wNlUh|ryP MmXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2MUmwOlUoRjF5NEG5NFY2RC:jPh?=
PC3 NGjN[FNEgXSxdH;4bYNqfHliYYPzZZk> NHy0WHJKSzVyIE2gNE4xPzdizszN M3L5UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
LoVo NITrboNEgXSxdH;4bYNqfHliYYPzZZk> NIH6S3pKSzVyIE2gNE4xQSEQvF2= NUfJeINtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVkxPjVpPkG3OFE6ODZ3PD;hQi=>
L2987 M3HifWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{n3c2lEPTBiPTCwMlIh|ryP M1u5NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG5NFY2Lz5zN{SxPVA3PTxxYU6=
cells MWHDfZRwfG:6aXPpeJkh[XO|YYm= M33rXGlEPTBiPTCwMlAxPTlizszN NVe2NIZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFI2PzdpPkG3OFQzPTd5PD;hQi=>
cells MkGyR5l1d3SxeHnjbZR6KGG|c3H5 MnixTWM2OCB;IECuNFEh|ryP MoXSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2OEWyNFcoRjF5NEi1NlA4RC:jPh?=
A2780 NFu1R4ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWnYZYtUUUN3MDC9JFAvODB{ODFOwG0> NYfIbZc2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
VA13 MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjhTWM2OCB;IECuNFA2KM7:TR?= NVnk[IVORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
WI38 NGfXb3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYLJR|UxKD1iMD6wOEDPxE1? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR7MEi3PEc,OTd2OUC4O|g9N2F-
2780AD NVT0XWRXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoH3TWM2OCB;IECuNVg{KM7:TR?= NWT4UJNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVA5PzhpPkG3OFkxQDd6PD;hQi=>
HepG2 Mk\ES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFfPZ5pKSzVyIE2gPE4yKM7:TR?= NILWemI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5NFg4QCd-MUe0PVA5Pzh:L3G+
HT29 MmrwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\XblQ5KGh? M1\pW2dKPTBiPTCwMlAyPSEQvF2= M4L6b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEm4PVYxLz5zN{S5PFk3ODxxYU6=
M21 NGTue29Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGm4dYQ1QCCq NE\EPVhIUTVyIE2gNE4xOzdizszN NUfLPG1VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0PVg6PjBpPkG3OFk5QTZyPD;hQi=>
MCF7 MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYW0PEBp M1e4e2dKPTBiPTCwMlA2PCEQvF2= NIDINII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S5PFk3OCd-MUe0PVg6PjB:L3G+
1A9 Mn3QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVS3NkBp NEDUPGtIUTVyIE2gNE4xODB5MTFOwG0> NELl[ZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W0NlU4Oid-MUe1OFI2PzJ:L3G+
1A9/Ptx22 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFruXXU4OiCq MU\HTVUxKD1iMD6wOVEh|ryP NUfuWJF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OFI2PzJpPkG3OVQzPTd{PD;hQi=>
1A9/Ptx10 M4TUTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVO3NkBp MkfwS2k2OCB;IECuNFY1KM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV2MkW3Nkc,OTd3NEK1O|I9N2F-
cells expressing MRP1 MkX0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3W5WGlEPTBiPTCwMlAxOjVizszN MlqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkexNlEoRjF5NU[3NVIyRC:jPh?=
cells expressing Pgp/MRP1 M1\WO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnrNTWM2OCB;IEKuO{DPxE1? MmLuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3NkexNlEoRjF5NU[3NVIyRC:jPh?=
VA13 MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFXtcoVKSzVyIE2gOUDPxE1? Mly3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3OUWxN|QoRjF5NUm1NVM1RC:jPh?=
MCF7 M2TPcmZ2dmO2aX;uJIF{e2G7 NGXNS3dKSzVyIE2gNE4xODF6IN88US=> Mln1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MEG3N|koRjF5NkCxO|M6RC:jPh?=
adriamycin-resistant MCF7 M2O3XWZ2dmO2aX;uJIF{e2G7 MoDUTWM2OCB;IEiuNkDPxE1? M3fnclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkCxO|M6Lz5zN{[wNVc{QTxxYU6=
RPMI8226 M2\VfmN6fG:2b4jpZ4l1gSCjc4PhfS=> NIG4XI5IUTVyIE2gNE4xODJizszN Moq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
HT29 NXO4eWsyS3m2b4TvfIlkcXS7IHHzd4F6 MXzHTVUxKD1iMD6wNFIh|ryP NFLKVnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
COLO205 Mof5R5l1d3SxeHnjbZR6KGG|c3H5 MmS5S2k2OCB;IECuNFA{KM7:TR?= NUfjWIwzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
HCC2998 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NIXhU|NIUTVyIE2gNE4xODNizszN NELYR5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
HS578T NG\O[mxEgXSxdH;4bYNqfHliYYPzZZk> NGfWb3hIUTVyIE2gNE4xODNizszN NHjkVJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
PC3 MoDvR5l1d3SxeHnjbZR6KGG|c3H5 MmO4S2k2OCB;IECuNFA1KM7:TR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
SNB75 NGLZO5lEgXSxdH;4bYNqfHliYYPzZZk> M1TYV2dKPTBiPTCwMlAxPCEQvF2= NGDhNok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
A549 NEHjbGFEgXSxdH;4bYNqfHliYYPzZZk> MlLhS2k2OCB;IECuNFA1KM7:TR?= NX\2[5V1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
KM12 NUT6eWQ3S3m2b4TvfIlkcXS7IHHzd4F6 NVXHTI8xT0l3MDC9JFAvODB2IN88US=> NVX3colRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVY{OzJpPkG3Olk3OzN{PD;hQi=>
DU145 M1G5dmN6fG:2b4jpZ4l1gSCjc4PhfS=> NGX6dmdIUTVyIE2gNE4xODVizszN MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
SK-OV3 MlnPR5l1d3SxeHnjbZR6KGG|c3H5 NGP1UoFIUTVyIE2gNE4xODhizszN MorzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OU[zN|IoRjF5Nkm2N|MzRC:jPh?=
NCI-H322M MlP5R5l1d3SxeHnjbZR6KGG|c3H5 M1HNXGdKPTBiPTCwMlAyOyEQvF2= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7NkOzNkc,OTd4OU[zN|I9N2F-
UACC257 M1TkVmN6fG:2b4jpZ4l1gSCjc4PhfS=> MY\HTVUxKD1iMD6wOEDPxE1? NFrqdG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
HCT15 NXnqOmY{S3m2b4TvfIlkcXS7IHHzd4F6 MUjHTVUxKD1iMD6xOVgh|ryP NFHnN|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5OlM{Oid-MUe2PVY{OzJ:L3G+
ACHN MXXDfZRwfG:6aXPpeJkh[XO|YYm= MV3HTVUxKD1iMD6zPVgh|ryP M{LOUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nkm2N|MzLz5zN{[5OlM{OjxxYU6=
HeLa NHHiOWFEgXSxdH;4bYNqfHliYYPzZZk> M1L2bGlEPTBiPTCwMlAxPTZizszN MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd4NEG0PEc,OTd5NkSxOFg9N2F-
MCF7 MYDDfZRwfG:6aXPpeJkh[XO|YYm= M4TPcGlEPTBiPTCwMlAyOjRizszN NUjUSXZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3OlQyPDhpPkG3O|Y1OTR6PD;hQi=>
A549 NIHaZYJEgXSxdH;4bYNqfHliYYPzZZk> MWrJR|UxKD1iMD6wNVI3KM7:TR?= MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd4NEG0PEc,OTd5NkSxOFg9N2F-
HGC27 M1fON2N6fG:2b4jpZ4l1gSCjc4PhfS=> MVjJR|UxKD1iMD63O|c5KM7:TR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzd4NEG0PEc,OTd5NkSxOFg9N2F-
HL60 MU\DfZRwfG:6aXPpeJkh[XO|YYm= M3rhW|czKGh? MoPyTWM2OCB;IECuPVMh|ryP NFrHUlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{i5OlgyPid-MUe4PVY5OTZ:L3G+
P388 NFjoO|JEgXSxdH;4bYNqfHliYYPzZZk> NGrKNm44OiCq MlG0TWM2OCB;IECuPVMh|ryP MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzh7NkixOkc,OTd6OU[4NVY9N2F-
BEL-7402 NX\iNIdQS3m2b4TvfIlkcXS7IHHzd4F6 MkPINlQhcA>? M1PC[WlEPTBiPTCwMlk{KM7:TR?= MoT5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OU[4NVYoRjF5OEm2PFE3RC:jPh?=
A459 MknHR5l1d3SxeHnjbZR6KGG|c3H5 NEW2TnMzPCCq MorKTWM2OCB;IECuPVMh|ryP NVzhSZdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe4PVY5OTZpPkG3PFk3QDF4PD;hQi=>
HeLa MX;DfZRwfG:6aXPpeJkh[XO|YYm= M2P0bGlEPTBiPTCwMlAzKM7:TR?= MkKzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUGwNVcoRjF5OUGxNFE4RC:jPh?=
HepG2 M3nzXGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mmr1TWM2OCB;IECuPFIh|ryP NFv2[Ig9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxNVAyPyd-MUe5NVExOTd:L3G+
BGC823 MoTIR5l1d3SxeHnjbZR6KGG|c3H5 MmL4TWM2OCB;IEGuNVUh|ryP MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzMUCxO{c,OTd7MUGwNVc9N2F-
Aro MXTDfZRwfG:6aXPpeJkh[XO|YYm= MoLOO|IhcA>? MVrJR|UxKD1iMD6wNFAzKM7:TR?= M4nrSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
PT45 NH3nZWxEgXSxdH;4bYNqfHliYYPzZZk> NUHNO2Q2PzJiaB?= NV7RN5ZOUUN3MDC9JFAvODB3IN88US=> NVG5fWdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
A549 MmHnR5l1d3SxeHnjbZR6KGG|c3H5 MU[3NkBp M2L1VGlEPTBiPTCwMlAxPiEQvF2= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
MCF7 NFfiV2NEgXSxdH;4bYNqfHliYYPzZZk> M{HaclczKGh? M4PrVmlEPTBiPTCwMlAxPyEQvF2= MoDlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
HeLa NEHGZ25EgXSxdH;4bYNqfHliYYPzZZk> MVS3NkBp M{nafmlEPTBiPTCwMlAxQCEQvF2= M{LJWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUG1PFUyLz5zN{mxOVg2OTxxYU6=
Ovcar3 MWTDfZRwfG:6aXPpeJkh[XO|YYm= MmrRO|IhcA>? M3z2TmlEPTBiPTCwMlAyKM7:TR?= NUjwdplTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5NVU5PTFpPkG3PVE2QDVzPD;hQi=>
HT29 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MoW2O|IhcA>? NYftVYRkUUN3MDC9JFAvODVizszN Mn2yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
A549T12 M1\1RWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlvLO|IhcA>? MoTxTWM2OCB;IECuNFYh|ryP MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
H295R NFvVUYNEgXSxdH;4bYNqfHliYYPzZZk> NX\QTIdbPzJiaB?= NUP1W2d6UUN3MDC9JFAvODhizszN MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
A549T24 Mlq5R5l1d3SxeHnjbZR6KGG|c3H5 M1L4NlczKGh? MXnJR|UxKD1iMD6xNFIh|ryP NFPZXFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{mxOVg2OSd-MUe5NVU5PTF:L3G+
OE33 NIPrblZEgXSxdH;4bYNqfHliYYPzZZk> Mn7BO|IhcA>? M4r3bmlEPTBiPTCwMlIh|ryP MmLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
HepG2 MoWxR5l1d3SxeHnjbZR6KGG|c3H5 MoX1O|IhcA>? NX7rOId5UUN3MDC9JFAvOyEQvF2= MomwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7MUW4OVEoRjF5OUG1PFUyRC:jPh?=
OE19 NGX1eGpEgXSxdH;4bYNqfHliYYPzZZk> NEjySWQ4OiCq NEC3PVBKSzVyIE2gNE41KM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzlzNUi1NUc,OTd7MUW4OVE9N2F-
L12 MmrXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NF;pPY01QCCq NF:5T3NKSzVyIE2gNE4xODZizszN NIjEXFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
NCI-H460 MVnDfZRwfG:6aXPpeJkh[XO|YYm= M1T0S|Q5KGh? NX6yRnJJUUN3MDC9JFAvODFizszN NILEUW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
SKOV3 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MV20PEBp MkHzTWM2OCB;IECuNFEh|ryP NFHXT4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{m3N|M3OSd-MUe5O|M{PjF:L3G+
SF268 M362RmN6fG:2b4jpZ4l1gSCjc4PhfS=> NV6z[5d6PDhiaB?= NFzURotKSzVyIE2gNE4xOSEQvF2= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
RKO MX;DfZRwfG:6aXPpeJkh[XO|YYm= MofBOFghcA>? M{SzS2lEPTBiPTCwMlAyKM7:TR?= M2LnVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUezN|YyLz5zN{m3N|M3OTxxYU6=
KB/HeLa MmHvR5l1d3SxeHnjbZR6KGG|c3H5 MVq0PEBp NUL6Wmo2UUN3MDC9JFAvODFizszN NWXkV2pHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5O|M{PjFpPkG3PVc{OzZzPD;hQi=>
P388 NFXkSHlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mn:4OFghcA>? M2jD[mlEPTBiPTCwMlA1KM7:TR?= MmfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis M{HpUWNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 NY\P[Ws{TUN3MDC9JFAvODR7IN88US=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
L1210 Ml7sRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NY\tfGJ{PDhiaB?= NGOwNm9KSzVyIE2gNE4xPiEQvF2= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl5M{O2NUc,OTd7N{OzOlE9N2F-
cells after 48 hrs by XTT assay M2nWdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHrFemhKSzVyIE2gNE41KM7:TR?= MmTLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd7N{OzOlEoRjF5OUezN|YyRC:jPh?=
A2780 M3zNR2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mmm4TWM2OCB;IECuNFA3OyEQvF2= NX2x[nR2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwNFExQDdpPkG4NFAyODh5PD;hQi=>
BGC823 NFryRmxEgXSxdH;4bYNqfHliYYPzZZk> NWfWO|BsUUN3MDC9JFAvODB5IN88US=> NWDnU2RXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwNFExQDdpPkG4NFAyODh5PD;hQi=>
A549 NVPlXZZ1S3m2b4TvfIlkcXS7IHHzd4F6 NWO2TXFSUUN3MDC9JFAvODF7IN88US=> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDByMUC4O{c,OThyMEGwPFc9N2F-
HCT8 MlXFR5l1d3SxeHnjbZR6KGG|c3H5 NVvWb49lUUN3MDC9JFAvODN5IN88US=> NGj1[GM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOECwNVA5Pyd-MUiwNFExQDd:L3G+
Bel7402 NInmNnREgXSxdH;4bYNqfHliYYPzZZk> MljnTWM2OCB;IECuNUDPxE1? NFfVfGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOECwNVA5Pyd-MUiwNFExQDd:L3G+
cells by alamar blue assay NXzxNpBZTnWwY4Tpc44h[XO|YYm= M{HDbmlEPTBiPTCwMlA1KM7:TR?= NVr1SZNERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwO|A6PjVpPkG4NFcxQTZ3PD;hQi=>
PANC1 M2\MOmN6fG:2b4jpZ4l1gSCjc4PhfS=> MkjzO|IhcA>? MkfYTWM2OCB;IECuNFA4KM7:TR?= Mnz1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyOEGyOVcoRjF6MEixNlU4RC:jPh?=
DLD1 NVjpSndlS3m2b4TvfIlkcXS7IHHzd4F6 MWC3NkBp NUWwcFFJUUN3MDC9JFAvODFzIN88US=> M4S3S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MEixNlU4Lz5zOEC4NVI2PzxxYU6=
AsPC1 NEXa[XREgXSxdH;4bYNqfHliYYPzZZk> NUPiTnBzPzJiaB?= NFeyVnJKSzVyIE2gNE4xOiEQvF2= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB6MUK1O{c,OThyOEGyOVc9N2F-
NCI/ADR M{GyT2N6fG:2b4jpZ4l1gSCjc4PhfS=> NF\kS2Y4OiCq MVjJR|UxKD1iMTFOwG0> MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB6MUK1O{c,OThyOEGyOVc9N2F-
SK-BR3 Ml\4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M{SzTlk3KGh? MkXYS2k2OCB;IE[uNUDPxE1? M2DJWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MU[0NlA2Lz5zOEG2OFIxPTxxYU6=
A2780 MknkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NIPTN2M6PiCq M33pVWlEPTBiPTCwMlAzOzRizszN NY\afIw5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUixO|cxOTRpPkG4NVc4ODF2PD;hQi=>
SNU398 NHf0VmVCeG:ydH;zbZMh[XO|YYm= M{j3OlI1KGh? MkHLSWM2OCB;IECuNFEyKM7:TR?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDF7N{[xOEc,OThzOUe2NVQ9N2F-
HCT116 NH6wc4FCeG:ydH;zbZMh[XO|YYm= MkHuNlQhcA>? MkTGSWM2OCB;IECuNFI1KM7:TR?= NGTqUW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEG5O|YyPCd-MUixPVc3OTR:L3G+
T47D NFXxOnZCeG:ydH;zbZMh[XO|YYm= MlryNlQhcA>? NVvWOmdTTUN3MDC9JFAvODN4IN88US=> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDF7N{[xOEc,OThzOUe2NVQ9N2F-
SJSA1 M1rEdWN6fG:2b4jpZ4l1gSCjc4PhfS=> NXrTWJBmPiCq Mn;aTWM2OCB;IECuNFA{OiEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ2M{[5Okc,OTh{NEO2PVY9N2F-
P388 M1HvRWN6fG:2b4jpZ4l1gSCjc4PhfS=> NF\wWYk4OiCq NGXJTotKSzVyIE2gNE46OyEQvF2= NWLrNWRiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyPFE6PTJpPkG4NlgyQTV{PD;hQi=>
HL60 M{nXdWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX:3NkBp MWjJR|UxKD1iMD65N{DPxE1? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ6MUm1Nkc,OTh{OEG5OVI9N2F-
Bel7402 MX3DfZRwfG:6aXPpeJkh[XO|YYm= MnXVNlQhcA>? NGHYdGVKSzVyIE2gNE46OyEQvF2= MoG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{OEG5OVIoRjF6MkixPVUzRC:jPh?=
A549 Mn7xR5l1d3SxeHnjbZR6KGG|c3H5 MV:yOEBp NH\meldKSzVyIE2gNE46OyEQvF2= NHfZe|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK4NVk2Oid-MUiyPFE6PTJ:L3G+
KB NFrXcphEgXSxdH;4bYNqfHliYYPzZZk> NYLF[nZNPDhiaB?= Mn23TWM2OCB;IECuNFA1OiEQvF2= NWjRVYMxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyPVU1QTBpPkG4Nlk2PDlyPD;hQi=>
KBV20C NHzLbWpEgXSxdH;4bYNqfHliYYPzZZk> NVXv[VA{PDhiaB?= MUjJR|UxKD1iMT60OEDPxE1? M1j6RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6Mkm1OFkxLz5zOEK5OVQ6ODxxYU6=
DU145 MWDDfZRwfG:6aXPpeJkh[XO|YYm= MoHQO|IhcA>? NWHTNG9rUUN3MDC9JFAvODB3IN88US=> NXTYVmVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFg2PjZpPkG4N|A5PTZ4PD;hQi=>
HL60 NXi2bok4S3m2b4TvfIlkcXS7IHHzd4F6 NUHidZRLPzJiaB?= MmG5TWM2OCB;IECuNFA2KM7:TR?= MnjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MEi1OlYoRjF6M{C4OVY3RC:jPh?=
MDA435 MYjDfZRwfG:6aXPpeJkh[XO|YYm= M3v3SFczKGh? MoT0TWM2OCB;IECuNFA2KM7:TR?= NI\4XJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwPFU3Pid-MUizNFg2PjZ:L3G+
MESSA MnPsR5l1d3SxeHnjbZR6KGG|c3H5 Mo\IO|IhcA>? NXq0bZJCUUN3MDC9JFAvODB3IN88US=> NG\rcZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwPFU3Pid-MUizNFg2PjZ:L3G+
P388 M1HDcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUK3NkBp MlrzTWM2OCB;IECuNFEh|ryP M1TxeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{C4OVY3Lz5zOEOwPFU3PjxxYU6=
HL60/TX1000 NHvKbZVEgXSxdH;4bYNqfHliYYPzZZk> NEnId2s4OiCq NUXFeZZHUUN3MDC9JFUh|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNyOEW2Okc,OTh|MEi1OlY9N2F-
MESSA/DX5 NGnwU5lEgXSxdH;4bYNqfHliYYPzZZk> MW[3NkBp M2DKOmlEPTBiPTC1JO69VQ>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNyOEW2Okc,OTh|MEi1OlY9N2F-
K562 MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX[3NkBp MUjJR|UxKD1iMD6wNFA3KM7:TR?= NW\POXJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
KB3-1 NYDaOWZuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{XwZVczKGh? M1nMbWlEPTBiPTCwMlAxOiEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNzM{OwO{c,OTh|MUOzNFc9N2F-
HepG2 MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV\jS4RbPzJiaB?= NWGxTGJ{UUN3MDC9JFAvODB5IN88US=> NW\tWHI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
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A549 NXHwTo1vS3m2b4TvfIlkcXS7IHHzd4F6 NHn2fGM{KGSjeYO= MVXJR|UxKD1iMD6wNFch|ryP NV\3SoM3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NVkyPTRpPkG4OFE6OTV2PD;hQi=>
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HepG2 MY\DfZRwfG:6aXPpeJkh[XO|YYm= MnHiN{Bl[Xm| MXnJR|UxKD1iMD6wOFY5KM7:TR?= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDRzOUG1OEc,OTh2MUmxOVQ9N2F-
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M21 M2TldWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlraS2k2OCB;IECuNFM4KM7:TR?= NVLZcoZbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1NFI3OzlpPkG4OVAzPjN7PD;hQi=>
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HT29 NY\WbXN{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGXTdZc1QCCq M{fGVWdKPTBiPTCwMlAyPSEQvF2= MmDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3N{mzPFcoRjF6NUe5N|g4RC:jPh?=
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CaCO2 M1zmeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NX\ENY9JOjRiaB?= MoHiTWM2OCB;IECuNFA5KM7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV6NkS5NUc,OTh3OE[0PVE9N2F-
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SF268 MX7DfZRwfG:6aXPpeJkh[XO|YYm= NIm2XZFKSzVyIE2gNE4xOTV|IN88US=> NVnCRVk1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2NFY2PDBpPkG4OlA3PTRyPD;hQi=>
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MDA-MB-231 NXTPXpFtS3m2b4TvfIlkcXS7IHHzd4F6 Ml7ETWM2OCB;IECuNFQxPSEQvF2= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZyNkW0NEc,OTh4ME[1OFA9N2F-
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MCF7 MkXUR5l1d3SxeHnjbZR6KGG|c3H5 M2jUS2lEPTBiPTCyMlk5KM7:TR?= M4fQT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{CxNlgyLz5zOEewNVI5OTxxYU6=
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K562 NXfYUnlrS3m2b4TvfIlkcXS7IHHzd4F6 MlvzTWM2OCB;IEOuOlUh|ryP NH3GRVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEewNVI5OSd-MUi3NFEzQDF:L3G+
HepG2 NXznenZqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYDSbGhSPDhiaB?= MlrBTWM2OCB;IECuOlIh|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDdyMUOwNUc,OTh5MEGzNFE9N2F-
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HCT116 NHnaTYdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MXu0PEBp NIrXNnVKSzVyIE2gOk4yQCEQvF2= NVziR3l4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3NFE{ODFpPkG4O|AyOzBzPD;hQi=>
A549 MkLIR5l1d3SxeHnjbZR6KGG|c3H5 MVnJR|UxKD1iMD6wNFIh|ryP NH3hdVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEexOVc5Oid-MUi3NVU4QDJ:L3G+
CCRF-CEM MXLDfZRwfG:6aXPpeJkh[XO|YYm= M4T2eFczKGh? NYTrNFJ2UUN3MDC9JFAvODBzMTFOwG0> NYK1T3VjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3OVI5PjlpPkG4O|UzQDZ7PD;hQi=>
SKOV3 M{C3dmFvfGmlYX7j[ZIh[XO|YYm= MVi3NkBp NWHFc5NLUUN3MDC9JFAvODBzM{Sg{txO NUj1Uo1WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3OlI{PThpPkG4O|YzOzV6PD;hQi=>
MCF7 NIjmVJBEgXSxdH;4bYNqfHliYYPzZZk> M4DHN2VFPTBiPTCwMlAxOzJizszN M4TQd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUK2O|AyLz5zOEmyOlcxOTxxYU6=
NCI/ADR-RES M1e4bGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIiyfGZGTDVyIE2gNU42KM7:TR?= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl{NkewNUc,OTh7Mk[3NFE9N2F-
PANC1 MV;DfZRwfG:6aXPpeJkh[XO|YYm= MYe3NkBp MnzuTWM2OCB;IECuNFA6QSEQvF2= NXvzTHU5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5OVE4QDdpPkG4PVUyPzh5PD;hQi=>
DLD1 NHPLZ5NEgXSxdH;4bYNqfHliYYPzZZk> NIPIPFY4OiCq Mlr0TWM2OCB;IECuNFIzKM7:TR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl3MUe4O{c,OTh7NUG3PFc9N2F-
AsPC1 MofOR5l1d3SxeHnjbZR6KGG|c3H5 NV[0VXBpPzJiaB?= MmX4TWM2OCB;IECuNFg6KM7:TR?= MmX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7NUG3PFcoRjF6OUWxO|g4RC:jPh?=
NCI/ADR-RES NXv3VIoyS3m2b4TvfIlkcXS7IHHzd4F6 MnrrO|IhcA>? M2PvdmlEPTBiPTCxMlMh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl3MUe4O{c,OTh7NUG3PFc9N2F-
MCF7 NEXjfY9EgXSxdH;4bYNqfHliYYPzZZk> NVXxVVZ[TUR3MDC9JFAvODB{MTFOwG0> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDl5N{[1PUc,OTh7N{e2OVk9N2F-
NCI/ADR-RES NFjoXolEgXSxdH;4bYNqfHliYYPzZZk> M1K2XGVFPTBiPTCyJO69VQ>? NHHLNYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEm3O|Y2QSd-MUi5O|c3PTl:L3G+
A431 MYrDfZRwfG:6aXPpeJkh[XO|YYm= NHTiVG44OiCq MUjJR|UxKD1iMD6wNlUyKM7:TR?= NVHmfGFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5PVA2PzRpPkG4PVkxPTd2PD;hQi=>
MCF7 M3P3NWN6fG:2b4jpZ4l1gSCjc4PhfS=> NH32[IY4OiCq MVXJR|UxKD1iMD6wN|kh|ryP NWjyc3VVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5PVA2PzRpPkG4PVkxPTd2PD;hQi=>
MDA-MB-231 M3PSbWN6fG:2b4jpZ4l1gSCjc4PhfS=> M1TSVFczKGh? NGrZ[VlKSzVyIE2gNE4xPDdzIN88US=> NVPhc3l2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5PVA2PzRpPkG4PVkxPTd2PD;hQi=>
SKOV3 NXi4SJFmS3m2b4TvfIlkcXS7IHHzd4F6 NH\kT|A4OiCq M{LpZWlEPTBiPTCwMlA3PThizszN NWLhU2FvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5PVA2PzRpPkG4PVkxPTd2PD;hQi=>
PANC1 NF\C[nZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXG3NkBp M1;6eGlEPTBiPTCwMlAxQTlizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB{Mk[3PUc,OTlyMkK2O|k9N2F-
DLD1 NFjPXWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{nNT|czKGh? MnLFTWM2OCB;IECuNFIzKM7:TR?= M3u3WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEKyOlc6Lz5zOUCyNlY4QTxxYU6=
AsPC1 M4PWfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1jB[lczKGh? M4[2XGlEPTBiPTCwMlA5QSEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB{Mk[3PUc,OTlyMkK2O|k9N2F-
NCI/ADR M3qzV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWDUU2YyPzJiaB?= MUjJR|UxKD1iMT6zJO69VQ>? MlrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyMkK2O|koRjF7MEKyOlc6RC:jPh?=
A2780 NV;TNIhuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVKyJIRigXN? MVvJR|UxKD1iMD6wNlM1KM7:TR?= NXfMXYp7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNlgyODJpPkG5NFI5OTB{PD;hQi=>
KB MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M2q5W|Mh\GG7cx?= MmXXTWM2OCB;IECuNFAzPSEQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB2MUK0O{c,OTlyNEGyOFc9N2F-
COLO205 MnX4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYGyOEBp NV;sXFdvUUN3MDC9JFAvODB|MzFOwG0> MmTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNEGyOFcoRjF7MESxNlQ4RC:jPh?=
KB 8.5 NInodXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{DMXlMh\GG7cx?= MlPITWM2OCB;IECuNFI3KM7:TR?= NFXLeGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC0NVI1Pyd-MUmwOFEzPDd:L3G+
KBV1 Mnq3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWTYRmJROyCmYYnz M3XmdmlEPTBiPTCyMlAyOyEQvF2= NHTzN4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC0NVI1Pyd-MUmwOFEzPDd:L3G+
KB MofFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXrVNY9VPzJiaB?= NIrWeodKSzVyIE2gNE4xODN|IN88US=> M3rRXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEWzO|c{Lz5zOUC1N|c4OzxxYU6=
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Pgp170 overexpressing multidrug resistant-KB-TAX50 NGXJc2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHPtXFY4OiCq M2j3VmlEPTBiPTCwMlI4OyEQvF2= MkGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUO3O|MoRjF7MEWzO|c{RC:jPh?=
NPC-TW01 NFLveWZEgXSxdH;4bYNqfHliYYPzZZk> MVu3NkBp MoDTTWM2OCB;IECuNFA3KM7:TR?= NGP3fXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c5OSd-MUmwOVM4QDF:L3G+
MES-SA NILXeZVEgXSxdH;4bYNqfHliYYPzZZk> MVe3NkBp Ml3BTWM2OCB;IECuNFA5KM7:TR?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e4NUc,OTlyNUO3PFE9N2F-
NCI-H838 MV\DfZRwfG:6aXPpeJkh[XO|YYm= NIDoPXQ4OiCq Mmm5TWM2OCB;IECuNFI3KM7:TR?= M4f5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEWzO|gyLz5zOUC1N|c5OTxxYU6=
HCT116 NUi2NJA6S3m2b4TvfIlkcXS7IHHzd4F6 MU[3NkBp MWjJR|UxKD1iMD6wOlEh|ryP NYnHOIVDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwOVM4QDFpPkG5NFU{PzhzPD;hQi=>
cells after 72 hrs by MTT assay NXnMZpY3S3m2b4TvfIlkcXS7IHHzd4F6 MXPJR|UxKD1iNT6xOEDPxE1? NF3nUWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC1N|c5OSd-MUmwOVM4QDF:L3G+
Hep3B MUPDfZRwfG:6aXPpeJkh[XO|YYm= NGrZSJg4OiCq MX\JR|UxKD1iNz6yOkDPxE1? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB3M{e4NUc,OTlyNUO3PFE9N2F-
A498 NFPhVVdEgXSxdH;4bYNqfHliYYPzZZk> NVrndXNvPzJiaB?= NXzsb2pmUUN3MDC9JFgvQDFizszN Mn3GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyNUO3PFEoRjF7MEWzO|gyRC:jPh?=
NB4 MYHDfZRwfG:6aXPpeJkh[XO|YYm= M3iwVlQ5KGh? NH;6c49KSzVyIE2gNE4yKM7:TR?= Mmn4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyN{KyNFkoRjF7MEeyNlA6RC:jPh?=
A549 M4m0UGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUD3OolrPDhiaB?= NVHXTXc1UUN3MDC9JFAvOSEQvF2= NXr2PYJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwO|IzODlpPkG5NFczOjB7PD;hQi=>
MCF7 MUDDfZRwfG:6aXPpeJkh[XO|YYm= M1r0SlQ5KGh? NFyzVG5KSzVyIE2gNE4yKM7:TR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5MkKwPUc,OTlyN{KyNFk9N2F-
SH-SY5Y NE\zUHNEgXSxdH;4bYNqfHliYYPzZZk> M37GXlQ5KGh? MWfJR|UxKD1iMD6yJO69VQ>? NG\2WVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC3NlIxQSd-MUmwO|IzODl:L3G+
PC3 MnXoR5l1d3SxeHnjbZR6KGG|c3H5 MoSwOFghcA>? NWjhb|QxUUN3MDC9JFAvOiEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTB5MkKwPUc,OTlyN{KyNFk9N2F-
DLD1 NXPBRYVVS3m2b4TvfIlkcXS7IHHzd4F6 Ml[4O|IhcA>? M3HyR2dKPTBiPTCwMlAyKM7:TR?= NUTURWxyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPFEzPDlpPkG5NFgyOjR7PD;hQi=>
B16 NF\CRZdEgXSxdH;4bYNqfHliYYPzZZk> MorWO|IhcA>? MX3HTVUxKD1iMD6wNUDPxE1? NXrSSGVDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPFEzPDlpPkG5NFgyOjR7PD;hQi=>
A172 NGDSfoxEgXSxdH;4bYNqfHliYYPzZZk> NUDLVYNVPzJiaB?= NHj6OVZIUTVyIE2gNE4xOSEQvF2= M4nnZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEixNlQ6Lz5zOUC4NVI1QTxxYU6=
HeLa NELKbpJEgXSxdH;4bYNqfHliYYPzZZk> MmnTO|IhcA>? M2XxbGdKPTBiPTCwMlAzKM7:TR?= M3\Ge|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEixNlQ6Lz5zOUC4NVI1QTxxYU6=
U87 NIDuU4ZEgXSxdH;4bYNqfHliYYPzZZk> MnXmO|IhcA>? NEDyUItIUTVyIE2gNE4xOiEQvF2= NEW5SoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC4NVI1QSd-MUmwPFEzPDl:L3G+
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HeLa MmrsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NU\2UnM{QTZiaB?= MnThTWM2OCB;IECuNFAyKM7:TR?= NU\sO2tjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPVE2PzlpPkG5NFkyPTd7PD;hQi=>
SKOV3 NXy5N4pPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MnfhPVYhcA>? M1rNbGlEPTBiPTCwMlAyPiEQvF2= M2fLdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEmxOVc6Lz5zOUC5NVU4QTxxYU6=
BGC823 M{PteWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NX34SphzQTZiaB?= NIHCXJJKSzVyIE2gNE4xOTh7IN88US=> MkjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyOUG1O|koRjF7MEmxOVc6RC:jPh?=
HCT116 M4j2fWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYTlNGJMPzJiaB?= NVHsbpBXUUN3MDC9JFAvODBzMTFOwG0> MlLFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMkSyOVAoRjF7MUK0NlUxRC:jPh?=
CCRF-CEM MlK2R5l1d3SxeHnjbZR6KGG|c3H5 NUixSY1lPzJiaB?= MmrVTWM2OCB;IECuNFA{OSEQvF2= NHPRTFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUGyOFI2OCd-MUmxNlQzPTB:L3G+
MX1 M2qwTmN6fG:2b4jpZ4l1gSCjc4PhfS=> M12xelczKGh? MoPMTWM2OCB;IECuNFQ3KM7:TR?= MnK0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzMkSyOVAoRjF7MUK0NlUxRC:jPh?=
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HT-29 NWnJeItPS3m2b4TvfIlkcXS7IHHzd4F6 MlXsOEBl[Xm| MlzLTWM2OCB;IECuNFA{PiEQvF2= NYnFWWN3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxNlgyPTZpPkG5NVI5OTV4PD;hQi=>
A2780 NH36d5JEgXSxdH;4bYNqfHliYYPzZZk> M1nTOVQ5KGh? MVXJR|UxKD1iMD6wNFE{KM7:TR?= M1fFcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MUK4PVczLz5zOUGyPFk4OjxxYU6=
KB Ml\ES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2fuWGVFPTBiPTCwMlAzOyEQvF2= NF:2N2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG2NVMyPid-MUmxOlE{OTZ:L3G+
HepG2 Mor2R5l1d3SxeHnjbZR6KGG|c3H5 NYrVUIJOT0l3MDC9JFAvODBzIN88US=> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF7NUmwNUc,OTlzOUW5NFE9N2F-
WI38 M1e0bmN6fG:2b4jpZ4l1gSCjc4PhfS=> MXLHTVUxKD1iMD6wNVM4KM7:TR?= NVz5cmlyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmxPVU6ODFpPkG5NVk2QTBzPD;hQi=>
RKO M4naPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mk[3TWM2OCB;IECuNFIh|ryP M{DUW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
KB/HeLa M3P6O2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlOxTWM2OCB;IECuNFMh|ryP MnPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkCwNVgoRjF7MkKwNFE5RC:jPh?=
SKOV3 MoizRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NXjic5BTUUN3MDC9JFAvODVizszN Mn20QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MkCwNVgoRjF7MkKwNFE5RC:jPh?=
SF268 M{TiR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MUXJR|UxKD1iMD6wOUDPxE1? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
P388 NVrUTJRDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NULuPYFJPDhiaB?= MXTJR|UxKD1iMD6wOUDPxE1? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ{MECxPEc,OTl{MkCwNVg9N2F-
cells ectopic expression of human M2T2Z2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGLYRpk1QCCq MVPJR|UxKD1iMD6wOUDPxE1? NYKwZ|hIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
L1210 NHzuW4dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEf3[2c1QCCq NXKxZ4xMUUN3MDC9JFAvODZizszN NXm1fGFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNlAxOThpPkG5NlIxODF6PD;hQi=>
NCI-H460 M{DmS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M2HYXWlEPTBiPTCwMlA4KM7:TR?= M3HmR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NV:wfYtsPDhiaB?= MlzWTWM2OCB;IECuN{DPxE1? M2P4flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkKwNFE5Lz5zOUKyNFAyQDxxYU6=
MCF7 NEDVOXREgXSxdH;4bYNqfHliYYPzZZk> MVm3NkBp M{TSbmlEPTBiPTCwMlAxOTJizszN NXjJbG13RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
A2780 NXTWbWRQS3m2b4TvfIlkcXS7IHHzd4F6 MWO3NkBp Mo\zTWM2OCB;IECuNFAyOzhizszN MlPoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
wild type A2780 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NYOxXGQ6PzJiaB?= MULJR|UxKD1iMD6wNFE4KM7:TR?= NWLwXHBGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
cisplatin-resistant A2780 MYXDfZRwfG:6aXPpeJkh[XO|YYm= MYm3NkBp MnHvTWM2OCB;IECuNFAzOiEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
LCC-6 NXfh[25PS3m2b4TvfIlkcXS7IHHzd4F6 M{TRRVczKGh? MlTNTWM2OCB;IECuNFAzPDVizszN M3TDTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
HT-29 MnS1R5l1d3SxeHnjbZR6KGG|c3H5 NXrGSpFHPzJiaB?= MWTJR|UxKD1iMD6wNFM3KM7:TR?= NWi3ZXIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
H460 NVu2c3VXS3m2b4TvfIlkcXS7IHHzd4F6 MYS3NkBp NV\pc|NDUUN3MDC9JFAvODB2OTFOwG0> M3\NcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
topotecan-resistant A2780 NGrBTm9EgXSxdH;4bYNqfHliYYPzZZk> MmXBO|IhcA>? MlH6TWM2OCB;IECuNFA4OiEQvF2= NVzXWJp7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
PANC1 M3H4dGN6fG:2b4jpZ4l1gSCjc4PhfS=> MXq3NkBp MkGyTWM2OCB;IECuNFI2PyEQvF2= MlLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{M{myOFAoRjF7MkO5NlQxRC:jPh?=
1A9PTX22 NHHqepdEgXSxdH;4bYNqfHliYYPzZZk> MUG3NkBp MnfUTWM2OCB;IECuNVYxPyEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
NCI/ADR NFrqZpJEgXSxdH;4bYNqfHliYYPzZZk> MWK3NkBp NWHxZlRxUUN3MDC9JFAvOyEQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ|OUK0NEc,OTl{M{myOFA9N2F-
A2780 MVTGeY5kfGmxbjDhd5NigQ>? NHHHd5RKSzVyIE2gNE4{QDZizszN NHH6SlY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUKzPVI1OCd-MUmyN|kzPDB:L3G+
1A9PTX10 MoD6R5l1d3SxeHnjbZR6KGG|c3H5 MXG3NkBp MULJR|UxKD1iMD61N|I6PSEQvF2= M37qV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkO5NlQxLz5zOUKzPVI1ODxxYU6=
A2780/ADR MVPDfZRwfG:6aXPpeJkh[XO|YYm= Mn3YO|IhcA>? MW\JR|UxKD1iMT6yN|kh|ryP NX7SPVhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyN|kzPDBpPkG5NlM6OjRyPD;hQi=>
A549 NYHFOVFvS3m2b4TvfIlkcXS7IHHzd4F6 NVThXolCOjRiaB?= MlHzTWM2OCB;IECuNFA2OiEQvF2= NIi4UHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK0OVI3OSd-MUmyOFUzPjF:L3G+
PC3M NWXMbFJiS3m2b4TvfIlkcXS7IHHzd4F6 M4HVXlI1KGh? M4mxfGlEPTBiPTCwMlAzPyEQvF2= MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ2NUK2NUc,OTl{NEWyOlE9N2F-
HCT8 MlL5R5l1d3SxeHnjbZR6KGG|c3H5 NIOyWW0zPCCq NHX4W3JKSzVyIE2gNE4xOzdizszN NHW2WWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK0OVI3OSd-MUmyOFUzPjF:L3G+
Bel7402 MUDDfZRwfG:6aXPpeJkh[XO|YYm= M2niPFI1KGh? Ml\DTWM2OCB;IECuNFk2KM7:TR?= NHTT[pA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK0OVI3OSd-MUmyOFUzPjF:L3G+
A2780 NFzkRWFEgXSxdH;4bYNqfHliYYPzZZk> M1zpWmlEPTBiPTCwMlAyPCEQvF2= NXrVSXdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFIyQDZpPkG5NlgzOTh4PD;hQi=>
SNU398 NGHxXJJCeG:ydH;zbZMh[XO|YYm= M2TDRVQ5KGh? NFXVN5BIUTVyIE2gNE4xOSEQvF2= NXTHZ4RlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFIyQDhpPkG5NlgzOTh6PD;hQi=>
HCT116 NIjQe3ZCeG:ydH;zbZMh[XO|YYm= M4HROFQ5KGh? M3;WVWVEPTBiPTCwMlAzOyEQvF2= NXW1eHRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyPFIyQDhpPkG5NlgzOTh6PD;hQi=>
T47D NFr1SGpCeG:ydH;zbZMh[XO|YYm= NFzJW4Y1QCCq M1rUUmVEPTBiPTCwMlA{PSEQvF2= NGXxeWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUK4NlE5QCd-MUmyPFIyQDh:L3G+
PC3 NIHk[WVEgXSxdH;4bYNqfHliYYPzZZk> NELTZYE1KGSjeYO= MoTRTWM2OCB;IECuNFAyPCEQvF2= MmHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|NUmxOlkoRjF7M{W5NVY6RC:jPh?=
A2780 NEDubpVEgXSxdH;4bYNqfHliYYPzZZk> M{LX[|Qh\GG7cx?= M17jOGlEPTBiPTCwMlAyPDlizszN M4fneVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{W5NVY6Lz5zOUO1PVE3QTxxYU6=
K562 MmTOR5l1d3SxeHnjbZR6KGG|c3H5 Mo[3OFghcA>? NWTxemc3UUN3MDC9JFEvOTZizszN NXfSWXgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzOVkyQDVpPkG5N|U6OTh3PD;hQi=>
MCF7 M4fSeWN6fG:2b4jpZ4l1gSCjc4PhfS=> NFP6emk1QCCq MWPJR|UxKD1iMj6xNUDPxE1? NGXESWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO1PVE5PSd-MUmzOVkyQDV:L3G+
A549 NYXnVYZGS3m2b4TvfIlkcXS7IHHzd4F6 MVu0PEBp MnrETWM2OCB;IEKuOFYh|ryP NILYSVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO1PVE5PSd-MUmzOVkyQDV:L3G+
SGC NF[3bm1EgXSxdH;4bYNqfHliYYPzZZk> NGXPTHY1QCCq MnzrTWM2OCB;IEOuN|Qh|ryP MmDDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|NUmxPFUoRjF7M{W5NVg2RC:jPh?=
HCT116 M2HUcmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2nnfFQ5KGh? NW\1bJFCUUN3MDC9JFQvOzdizszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN3OUG4OUc,OTl|NUmxPFU9N2F-
A431 NV;oeFc5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NF3UVotIUTVyIE2gNE4xODByMTFOwG0> M1LLTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{m0NlE5Lz5zOUO5OFIyQDxxYU6=
MESSA NWO3bIZGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NEL6SmtIUTVyIE2gNE4xODByMTFOwG0> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN7NEKxPEc,OTl|OUSyNVg9N2F-
HCT15 M3fPdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnTXS2k2OCB;IECuNFEyKM7:TR?= NGTPe5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO5OFIyQCd-MUmzPVQzOTh:L3G+
MES-SA/Dx5 NHTGc3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkfMS2k2OCB;IECuNVYh|ryP NXzCW|RPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVQzOThpPkG5N|k1OjF6PD;hQi=>
HCT15/CLO2 M3H3OGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVHHTVUxKD1iMD64N{DPxE1? NV3mZ3piRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzPVQzOThpPkG5N|k1OjF6PD;hQi=>
wild type A2780 NW\Qe2dTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHSyWXA4OiCq NGn3XZFKSzVyIE2gNE4xODF5IN88US=> NIPlNGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyN|M1OCd-MUm0NlM{PDB:L3G+
cisplatin-resistant A2780 MlGwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVy3NkBp MYjJR|UxKD1iMD6wNFIzKM7:TR?= NGPzRng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyN|M1OCd-MUm0NlM{PDB:L3G+
topotecan-resistant A2780 M4[ySGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPGO|IhcA>? MUnJR|UxKD1iMD6wNFczKM7:TR?= MkfoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkOzOFAoRjF7NEKzN|QxRC:jPh?=
adriamycin and doxorubicin-resistant A2780 MnnZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmC5O|IhcA>? MVTJR|UxKD1iMT6yN|kh|ryP MlXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkOzOFAoRjF7NEKzN|QxRC:jPh?=
paclitaxel-resistant A2780TC1 MYXGeY5kfGmxbjDhd5NigQ>? MmrmTWM2OCB;IEWuPFk5KM7:TR?= MmHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkOzOFAoRjF7NEKzN|QxRC:jPh?=
NB4 MknIR5l1d3SxeHnjbZR6KGG|c3H5 NYrmRnVwPDhiaB?= NVXORY5bUUN3MDC9JFAvOSEQvF2= NFnDSXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyOVU5QSd-MUm0NlU2QDl:L3G+
A549 M2DFb2N6fG:2b4jpZ4l1gSCjc4PhfS=> MknSOFghcA>? M4TWdGlEPTBiPTCwMlEh|ryP M4DmUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEK1OVg6Lz5zOUSyOVU5QTxxYU6=
MCF7 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MWC0PEBp NHm3SmVKSzVyIE2gNE4yKM7:TR?= Mn;SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2MkW1PFkoRjF7NEK1OVg6RC:jPh?=
SH-SY5Y M4rMcGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmfyOFghcA>? MVLJR|UxKD1iMD6yJO69VQ>? NVrwfotIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NlU2QDlpPkG5OFI2PTh7PD;hQi=>
PC3 MWTDfZRwfG:6aXPpeJkh[XO|YYm= M3rsblQ5KGh? MVjJR|UxKD1iMD6yJO69VQ>? NHLXWJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSyOVU5QSd-MUm0NlU2QDl:L3G+
SNU398 M3XzfGFxd3C2b4Ppd{Bie3OjeR?= MVm0PEBp Mm[ySWM2OCB;IECuNFA6KM7:TR?= MkfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2Nke1PVgoRjF7NE[3OVk5RC:jPh?=
HCT116 M1[xNmFxd3C2b4Ppd{Bie3OjeR?= M3yzWFQ5KGh? Mn61SWM2OCB;IECuNFE5KM7:TR?= NUniZ5NQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olc2QThpPkG5OFY4PTl6PD;hQi=>
T47D NGKw[W1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorQOFghcA>? MVrHTVUxKD1iMD6wNlYh|ryP NX3tNXpKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olc2QThpPkG5OFY4PTl6PD;hQi=>
MCF7 NHe5fGVEgXSxdH;4bYNqfHliYYPzZZk> NF33SHA1QCCq M{TlWmlEPTBiPTCwMlA5KM7:TR?= M1ru[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NE[3PFc4Lz5zOUS2O|g4PzxxYU6=
HepG2 M1fVR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3e2UmdKPTBiPTCwMlA2QSEQvF2= NUi1eVlTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0O|Y{OzZpPkG5OFc3OzN4PD;hQi=>
H1299 NXrsb|h2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW[0PEBp M3vCVGdKPTBiPTCwMlAzOyEQvF2= NWnQS2xzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1NFA6PzZpPkG5OVAxQTd4PD;hQi=>
T47D NFPIOWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NImzZVg1QCCq NXjnWWtPT0l3MDC9JFAvODJ4IN88US=> NELaelI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUWwNFk4Pid-MUm1NFA6PzZ:L3G+
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HCT116 NUXafnRNS3m2b4TvfIlkcXS7IHHzd4F6 NEHoTo84OiCq M4jqOWlEPTBiPTCwMlAxOTFizszN NUH5XlNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1O|Y4QDVpPkG5OVc3Pzh3PD;hQi=>
CCRF-CEM NVH1bGVFS3m2b4TvfIlkcXS7IHHzd4F6 MYi3NkBp M1LkZ2lEPTBiPTCwMlAxOTJizszN NV;3PXhjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1O|Y4QDVpPkG5OVc3Pzh3PD;hQi=>
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vinblastine-resistant CCRF-CEM MorpR5l1d3SxeHnjbZR6KGG|c3H5 MW[3NkBp NHfOVJZKSzVyIE2gNE41KM7:TR?= MnL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3N{[3PFUoRjF7NUe2O|g2RC:jPh?=
taxol-resistant CCRF-CEM MlTSR5l1d3SxeHnjbZR6KGG|c3H5 MYm3NkBp NWHpdXFWUUN3MDC9JFEvOiEQvF2= MmH4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3N{[3PFUoRjF7NUe2O|g2RC:jPh?=
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PtK2 NEjFXGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTDTWM2OCB;IECuNFIyKM7:TR?= NFPq[o09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[wNVU6PCd-MUm2NFE2QTR:L3G+
rat A10 NF[1bW5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXHme5ZQUUN3MDC9JFAvODN6IN88US=> NGn3SXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[wNVU6PCd-MUm2NFE2QTR:L3G+
HCT116 NGPZbZJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2PXV|czKGh? MmPoTWM2OCB;IECuNFAxQCEQvF2= MnLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl4NkWzPFQoRjF7Nk[1N|g1RC:jPh?=
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MES-SA/Dx5 MXPDfZRwfG:6aXPpeJkh[XO|YYm= MmmyTWM2OCB;IEeuOVM5KM7:TR?= M{nZdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7Nke5OFc2Lz5zOU[3PVQ4PTxxYU6=
A549 NYDUc|ExS3m2b4TvfIlkcXS7IHHzd4F6 NF:xVGhKSzVyIE2gNE4xODJ|IN88US=> NY\lc3hsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NFg3PzlpPkG5O|A5Pjd7PD;hQi=>
BGC823 NWrSdmhHS3m2b4TvfIlkcXS7IHHzd4F6 MXPJR|UxKD1iMD6wNFM{KM7:TR?= NInKUlI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUewPFY4QSd-MUm3NFg3Pzl:L3G+
HCT8 M{DZPWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYOxeGNWUUN3MDC9JFAvODB|NjFOwG0> MnezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5MEi2O|koRjF7N{C4Olc6RC:jPh?=
A2780 NX\UWIdqS3m2b4TvfIlkcXS7IHHzd4F6 NVPi[Fh1UUN3MDC9JFAvODB5OTFOwG0> NVPRZXpLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm3NFg3PzlpPkG5O|A5Pjd7PD;hQi=>
Bel7404 NYHNSGVmS3m2b4TvfIlkcXS7IHHzd4F6 NXSyd3FNUUN3MDC9JFAvODF{MzFOwG0> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTdyOE[3PUc,OTl5MEi2O|k9N2F-
DG75 NHPlN4ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXjQ[Yp[OjRidH:gO|IhcA>? NWPtXpZMUUN3MDC9JFAvODFizszN NGDQZow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUexO|IyPSd-MUm3NVczOTV:L3G+
MUTU-I NITtZlhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWOyOEBp MWnJR|UxKD1iMD6wNUDPxE1? NGn2eHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUexO|IyPSd-MUm3NVczOTV:L3G+
HCT116 NXfqcnZNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mni1O|IhcA>? NUXU[5cyUUN3MDC9JFAvODBzIN88US=> NHfhSm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe0N|g3Oyd-MUm3OFM5PjN:L3G+
SW48 NEDlNoZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NFfaNFM4OiCq NIrtfYlKSzVyIE2gNE4xODFizszN MoC1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5NEO4OlMoRjF7N{SzPFY{RC:jPh?=
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SW480 MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NG\qWWQ4OiCq Mn\QTWM2OCB;IECuNFAzKM7:TR?= M4exb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{SzPFY{Lz5zOUe0N|g3OzxxYU6=
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RL NEjnOVJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MnqzO|IhcA>? NH[1PFZKSzVyIE2gNE4xODNizszN M2rxUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{SzPFY{Lz5zOUe0N|g3OzxxYU6=
T47D NVzuPJhrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4W0R|czKGh? NETSVoJKSzVyIE2gNE4xODRizszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd2M{i2N{c,OTl5NEO4OlM9N2F-
UACC-812 MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NILKXmo4OiCq MkL2TWM2OCB;IECuO{DPxE1? M4rJNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{SzPFY{Lz5zOUe0N|g3OzxxYU6=
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HCT116 MYDDfZRwfG:6aXPpeJkh[XO|YYm= Ml7rNUBp MUTJR|UxKD1iMD6wNFM2KM7:TR?= M4HlclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{e4NFY4Lz5zOUe3PFA3PzxxYU6=
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A549 NGXhUZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NVvLdnh3PDhiaB?= NEPzRZJKSzVyIE2gNk4zQCEQvF2= Mni4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6MUWzNVYoRjF7OEG1N|E3RC:jPh?=
SGC7901 NFzkPWRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIfmPXQ1QCCq MnH3TWM2OCB;IEOuN|Qh|ryP NGfYd2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUixOVMyPid-MUm4NVU{OTZ:L3G+
HCT116 NYLSOppzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MmiwOFghcA>? NEi1eWpKSzVyIE2gOE4{PyEQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQThzNUOxOkc,OTl6MUWzNVY9N2F-
IGROV1 NEDjenpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NIPRZlU4OiCq NVXZbYlUUUN3MDC9JFAvODZizszN Moi2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6M{O1NVUoRjF7OEOzOVE2RC:jPh?=
MCF7 M1rKNWN6fG:2b4jpZ4l1gSCjc4PhfS=> NInCPI44OiCq MnvYTWM2OCB;IECuNFAzKM7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTh4MEO4N{c,OTl6NkCzPFM9N2F-
A2780 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NW\BOoxtUUN3MDC9JFAvODB{ODFOwG0> NV\pZXJRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4O|c3PTNpPkG5PFc4PjV|PD;hQi=>
A2780AD M1Lv[WN6fG:2b4jpZ4l1gSCjc4PhfS=> M2jjeGlEPTBiPTCwMlQyPSEQvF2= M2XVeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEe3OlU{Lz5zOUi3O|Y2OzxxYU6=
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KB MmW1R5l1d3SxeHnjbZR6KGG|c3H5 MXPJR|UxKD1iMD6wPEDPxE1? MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{N{eyNUc,OjB4Mke3NlE9N2F-
786-0 MWfDfZRwfG:6aXPpeJkh[XO|YYm= NXnIZ5JyUUN3MDC9JFAvODhizszN NITzXY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
HepG2 MVTDfZRwfG:6aXPpeJkh[XO|YYm= M2LmTGlEPTBiPTCwMlA5KM7:TR?= M2SxeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK3O|IyLz5{ME[yO|czOTxxYU6=
OS-RC2 M{D0[GN6fG:2b4jpZ4l1gSCjc4PhfS=> M4TwNGlEPTBiPTCwMlA5KM7:TR?= NWS4NFhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2Nlc4OjFpPkKwOlI4PzJzPD;hQi=>
22Rv1 M2CzeGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHnvS3dKSzVyIE2gNE4xQCEQvF2= NHjPR2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
HT-29 MkLhR5l1d3SxeHnjbZR6KGG|c3H5 NGG3fWFKSzVyIE2gNE4{QCEQvF2= NH22d4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
A375 MmX4R5l1d3SxeHnjbZR6KGG|c3H5 Ml3nTWM2OCB;IECuPFEh|ryP M1jpUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNkK3O|IyLz5{ME[yO|czOTxxYU6=
MCF7 MXPDfZRwfG:6aXPpeJkh[XO|YYm= M{XBTGlEPTBiPTCxMlMh|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODZ{N{eyNUc,OjB4Mke3NlE9N2F-
BCG823 NFfaZolEgXSxdH;4bYNqfHliYYPzZZk> M4HIWmlEPTBiPTCxMlUh|ryP NGf5Olc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[yO|czOSd-MkC2Nlc4OjF:L3G+
769-P M{W4NmN6fG:2b4jpZ4l1gSCjc4PhfS=> MmXuTWM2OCB;IEeuNUDPxE1? NXjteoo1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2Nlc4OjFpPkKwOlI4PzJzPD;hQi=>
KB NUn0To1FS3m2b4TvfIlkcXS7IHHzd4F6 NH31dHlKSzVyIE2gNE4xQCEQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
786-0 M2jtSWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlT2TWM2OCB;IECuNFgh|ryP M2HPXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{G2OFY5Lz5{MEexOlQ3QDxxYU6=
OS-RC2 NHXsSoxEgXSxdH;4bYNqfHliYYPzZZk> NIP1TGJKSzVyIE2gNE4xQCEQvF2= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
22Rv1 NILyPY5EgXSxdH;4bYNqfHliYYPzZZk> Mln5TWM2OCB;IECuNFgh|ryP MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
HepG2 MYPDfZRwfG:6aXPpeJkh[XO|YYm= NHrjOINKSzVyIE2gNE4xQCEQvF2= MoO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5MU[0OlgoRjJyN{G2OFY5RC:jPh?=
HT-29 NYLSd3NnS3m2b4TvfIlkcXS7IHHzd4F6 Mn;HTWM2OCB;IECuN|gh|ryP NGKwSGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEexOlQ3QCd-MkC3NVY1Pjh:L3G+
A375 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NXzidpg6UUN3MDC9JFAvQDFizszN NVjrNGhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3NVY1PjhpPkKwO|E3PDZ6PD;hQi=>
MCF7 MWHDfZRwfG:6aXPpeJkh[XO|YYm= NWTwXnd6UUN3MDC9JFEvOyEQvF2= MlztQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5MU[0OlgoRjJyN{G2OFY5RC:jPh?=
BGC823 NFzOS5lEgXSxdH;4bYNqfHliYYPzZZk> NFnxdolKSzVyIE2gNU42KM7:TR?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
769-P NESycVdEgXSxdH;4bYNqfHliYYPzZZk> M1TXbmlEPTBiPTC3MlEh|ryP MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzNkS2PEc,OjB5MU[0Olg9N2F-
BGC823 NH\He|BEgXSxdH;4bYNqfHliYYPzZZk> MXO3NkBp MlO2TWM2OCB;IECuNFAyKM7:TR?= NGjWR3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEexPVUyOCd-MkC3NVk2OTB:L3G+
A2780 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NWD6Wm9QPzJiaB?= MoHLTWM2OCB;IECuNFAyKM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzOUWxNEc,OjB5MUm1NVA9N2F-
A549 NVLqWlNlS3m2b4TvfIlkcXS7IHHzd4F6 NITSVIQ4OiCq MX7JR|UxKD1iMD6wNVYh|ryP Mn7JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB5MUm1NVAoRjJyN{G5OVExRC:jPh?=
HCT8 MYrDfZRwfG:6aXPpeJkh[XO|YYm= M3XNelczKGh? MkjETWM2OCB;IECuNFUyKM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODdzOUWxNEc,OjB5MUm1NVA9N2F-
Bel7402 NFfWWYFEgXSxdH;4bYNqfHliYYPzZZk> M2KySFczKGh? MlXMTWM2OCB;IECuNFYh|ryP NWXrcWJORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3NVk2OTBpPkKwO|E6PTFyPD;hQi=>
A549 Ml;KR5l1d3SxeHnjbZR6KGG|c3H5 MXi3NkBp MWrJR|UxKD1iMD6wNFM5KM7:TR?= M3rId|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{OyPFA6Lz5{MEezNlgxQTxxYU6=
HEK NFTxNldEgXSxdH;4bYNqfHliYYPzZZk> NXLKcFhFPzJiaB?= NWDCV3ZPUUN3MDC9JFAvODB|OTFOwG0> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|MkiwPUc,OjB5M{K4NFk9N2F-
MCF7 NFjTXpdEgXSxdH;4bYNqfHliYYPzZZk> M3K4cFczKGh? NFO4NIJKSzVyIE2gNE4xODR2IN88US=> NYO4XpRKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC3N|I5ODlpPkKwO|MzQDB7PD;hQi=>
HeLa MljHR5l1d3SxeHnjbZR6KGG|c3H5 NELOUoY4OiCq Mn\zTWM2OCB;IECuNFA5QSEQvF2= NITqc5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEezNlgxQSd-MkC3N|I5ODl:L3G+
Hep3B MmPnRY51cWOjbnPldkBie3OjeR?= NHjQW20{KGSjeYO= NEDYXm5IUTVyIE2gNE4xODB2IN88US=> NHLsUI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEezOVE1OCd-MkC3N|UyPDB:L3G+
DU145 M{[xcGN6fG:2b4jpZ4l1gSCjc4PhfS=> M33xNmVFPTBiPTCwMlAxOyEQvF2= M{D3[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{O4NVA{Lz5{MEezPFExOzxxYU6=
KB NGXtbotEgXSxdH;4bYNqfHliYYPzZZk> NFTWVG5GTDVyIE2gNE4xODdizszN MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODd|OEGwN{c,OjB5M{ixNFM9N2F-
A549 NEj3[WZEgXSxdH;4bYNqfHliYYPzZZk> MmPySWQ2OCB;IECuNFA5KM7:TR?= M1vjfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyN{O4NVA{Lz5{MEezPFExOzxxYU6=
MCF7 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NV;aNoMzPzJiaB?= MVrJR|UxKD1iMD6wNFIh|ryP NIn4SHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEiwNFUxOCd-MkC4NFA2ODB:L3G+
wild type LCC-6 MVfDfZRwfG:6aXPpeJkh[XO|YYm= Mo\EO|IhcA>? M4rwfGlEPTBiPTCwMlAxOyEQvF2= NWfLcGFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NFA2ODBpPkKwPFAxPTByPD;hQi=>
A2780 M2HNdmN6fG:2b4jpZ4l1gSCjc4PhfS=> NVvo[nBwPzJiaB?= NXPDfnZnUUN3MDC9JFAvODJizszN NVvDZnU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NFA2ODBpPkKwPFAxPTByPD;hQi=>
CFPAC-1 NUHDOXhQS3m2b4TvfIlkcXS7IHHzd4F6 NFrRWXU4OiCq MUTJR|UxKD1iMD6wOFch|ryP M3T2[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOECwOVAxLz5{MEiwNFUxODxxYU6=
multidrug-resistant LCC-6 NXnq[YhlS3m2b4TvfIlkcXS7IHHzd4F6 NFPhS4I4OiCq M1jGUmlEPTBiPTCwMlM4QSEQvF2= MnHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MEC1NFAoRjJyOECwOVAxRC:jPh?=
NCI/ADR MXHDfZRwfG:6aXPpeJkh[XO|YYm= NEHHdHQ4OiCq NHn2fJRKSzVyIE2gNE41OSEQvF2= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhyMEWwNEc,OjB6MEC1NFA9N2F-
multidrug-resistant MDA-MB-435/LCCMDR1 Mm\GR5l1d3SxeHnjbZR6KGG|c3H5 MWK0PEBp NHvORoRKSzVyIE2gNE4xODRizszN NUKzcHo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC5NVk4OjBpPkKwPVE6PzJyPD;hQi=>
multidrug-resistant MDA-MB-435/LCCMDR1 Moe3SpVv[3Srb36gZZN{[Xl? Mmj2TWM2OCB;IECuNFY6OyEQvF2= MoW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7MUm3NlAoRjJyOUG5O|IxRC:jPh?=
MDA-MB-435 MlroR5l1d3SxeHnjbZR6KGG|c3H5 M{jNelQ5KGh? NUHkOVZEUUN3MDC9JFAvOjd5IN88US=> MmrTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7MUm3NlAoRjJyOUG5O|IxRC:jPh?=
LNCAP M37QNmN6fG:2b4jpZ4l1gSCjc4PhfS=> M4DGWGlEPTBiPTCwMlAzOjNizszN Mk\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7M{[4O|QoRjJyOUO2PFc1RC:jPh?=
HT-29 NHS1NFlEgXSxdH;4bYNqfHliYYPzZZk> MUSzJIRigXN? MX;FSFUxKD1iMD6wNFA3KM7:TR?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl|OUW0NEc,OjB7M{m1OFA9N2F-
HCT116 NILoSY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWe2dWFLQTZiaB?= NWjrW2tIUUN3MDC9JFAvODB{IN88US=> MoTSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7NEO0NFEoRjJyOUSzOFAyRC:jPh?=
HCT15 M2f0XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NITneZc6PiCq M1vDb2lEPTBiPTCwMlE1KM7:TR?= M{HGXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUSzOFAyLz5{MEm0N|QxOTxxYU6=
HeLa NWXN[lhrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NHfZ[21KSzVyIE2gNE4xODF4IN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl5M{S4PEc,OjB7N{O0PFg9N2F-
SKOV3 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXXlSGZvUUN3MDC9JFAvODB|IN88US=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODl5M{S4PEc,OjB7N{O0PFg9N2F-
A549 M4\LNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXTGe5RjQTZiaB?= M3z4U2lEPTBiPTCwMlAxPDlizszN M2nmTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOUe0OVA2Lz5{MEm3OFUxPTxxYU6=
MCF7 MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3K4VFk3KGh? M{[wT2lEPTBiPTCwMlAzOSEQvF2= MnzZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB7N{S1NFUoRjJyOUe0OVA2RC:jPh?=
HT-29 NGDsUmVCdnSrY3HuZ4VzKGG|c3H5 NIrBfWFGTDVyIE2gNE4xODBzIN88US=> MljOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyNkeyNFYoRjJzME[3NlA3RC:jPh?=
K562 NFXae3dEgXSxdH;4bYNqfHliYYPzZZk> NVvMfVJKPDhiaB?= NX7jVYY2UUN3MDC9JFEvOTZizszN NUjnRZNMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwOlc6OzNpPkKxNFY4QTN|PD;hQi=>
MCF7 NH:1VVVEgXSxdH;4bYNqfHliYYPzZZk> NYfOSnFnPDhiaB?= M2joZWlEPTBiPTCyMlEyKM7:TR?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB4N{mzN{c,OjFyNke5N|M9N2F-
A549 MXjDfZRwfG:6aXPpeJkh[XO|YYm= NUL6[GY{PDhiaB?= M3rlb2lEPTBiPTCyMlQ3KM7:TR?= NGrvOYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC2O|k{Oyd-MkGwOlc6OzN:L3G+
SGC MYfDfZRwfG:6aXPpeJkh[XO|YYm= NGjpW5Y1QCCq NILkXI1KSzVyIE2gN{4{PCEQvF2= NHnWe3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC2O|k{Oyd-MkGwOlc6OzN:L3G+
HCT116 MWnDfZRwfG:6aXPpeJkh[XO|YYm= MnfDOFghcA>? Mn7mTWM2OCB;IESuN|ch|ryP MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB4N{mzN{c,OjFyNke5N|M9N2F-
CCRF-CEM NHmzXnhEgXSxdH;4bYNqfHliYYPzZZk> NGPaW3Q4OiCq MVXJR|UxKD1iMD6wNFMh|ryP MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFyNkO3O{c,OjFzME[zO|c9N2F-
MCF7 NXjMTodKS3m2b4TvfIlkcXS7IHHzd4F6 NUnuVFFbPzJiaB?= NH3xfo9IUTVyIE2gNE4xODNizszN MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUKxNEc,OjFzMUWyNVA9N2F-
HT-29 M33LfGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHXySGw4OiCq MlizS2k2OCB;IECuNFA{KM7:TR?= Mor4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzMUWyNVAoRjJzMUG1NlExRC:jPh?=
K562 NVjKOWc3S3m2b4TvfIlkcXS7IHHzd4F6 M3jZSlczKGh? MWTHTVUxKD1iMD6wNFQh|ryP NVLieWxQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNVUzOTBpPkKxNVE2OjFyPD;hQi=>
PC3 MX\DfZRwfG:6aXPpeJkh[XO|YYm= NUnUfGxLPzJiaB?= NUS3PFlbT0l3MDC9JFAvODB2IN88US=> NHG1Xms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGxOVIyOCd-MkGxNVUzOTB:L3G+
MCF7 MoTzR5l1d3SxeHnjbZR6KGG|c3H5 NF;jcHczPCCq MUHJR|UxKD1iMD62N{DPxE1? M3XXOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUG1NlEzLz5{MUGxOVIyOjxxYU6=
SMMC7721 NGPpPIhEgXSxdH;4bYNqfHliYYPzZZk> M1PXNlI1KGh? MUfJR|UxKD1iMT60NkDPxE1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTFzNUKxNkc,OjFzMUWyNVI9N2F-
A2780 NYTH[Ww2S3m2b4TvfIlkcXS7IHHzd4F6 NH;Ofmg1QCC2bzC3NkBp MUDJR|UxKD1iMD6wNUDPxE1? NGr0VJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyOlAzPyd-MkGxNlYxOjd:L3G+
Jurkat MXTD[YxtKGO7Y3zlJIFzemW|dDDhd5NigQ>? MmOzNlQhcA>? NVK3Z3FCUUN3MDC9JFAvODFizszN NVL6c2xkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxNlYxOjdpPkKxNVI3ODJ5PD;hQi=>
HeLa NHW0b5FEgXSxdH;4bYNqfHliYYPzZZk> NI\Oe4M1QCC2bzC3NkBp NUXMbXRPUUN3MDC9JFAvODJizszN M4LEXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUK2NFI4Lz5{MUGyOlAzPzxxYU6=
SW620 NX:wZW06S3m2b4TvfIlkcXS7IHHzd4F6 NUjSRVduPDhidH:gO|IhcA>? M2S1W2lEPTBiPTCwMlA{KM7:TR?= NFqw[289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGyOlAzPyd-MkGxNlYxOjd:L3G+
HCT116 NH7GfXJEgXSxdH;4bYNqfHliYYPzZZk> NHjwTIg4OiCq NXj1Rnl5UUN3MDC9JFAvODBzMzFOwG0> M4\EbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUS0O|U3Lz5{MUG0OFc2PjxxYU6=
CCRF-CEM M3HjcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NXjO[mRrPzJiaB?= MVjJR|UxKD1iMD6wNFMh|ryP Ml3VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNES3OVYoRjJzMUS0O|U3RC:jPh?=
MX1 MUDDfZRwfG:6aXPpeJkh[XO|YYm= MknuO|IhcA>? NWLEOZFtUUN3MDC9JFAvODN3IN88US=> Mni1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFzNES3OVYoRjJzMUS0O|U3RC:jPh?=
chemoresistant DG75 NET1WlJEgXSxdH;4bYNqfHliYYPzZZk> M3nyWFczKGh? NVTrUm1lUUN3MDC9JFAvODFizszN M{e2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkK3O|AzLz5{MUKyO|cxOjxxYU6=
chemosensitive MUTU-I Mn7qR5l1d3SxeHnjbZR6KGG|c3H5 MkOxNlQhcA>? Ml7sTWM2OCB;IECuNFEh|ryP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ{N{ewNkc,OjF{Mke3NFI9N2F-
HT1080 M1ftUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MWO5OkBp NILpcVNKSzVyIE2gNE4xODF{IN88US=> NEXk[2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5OlQ3Pyd-MkGyPVY1Pjd:L3G+
A549 M1y5W2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NH\2b286PiCq MkWyTWM2OCB;IECuNFA1PCEQvF2= M1vJUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm2OFY4Lz5{MUK5OlQ3PzxxYU6=
A375 NYjKV2lzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Mle5PVYhcA>? NHnGR5VKSzVyIE2gNE4xODR4IN88US=> NVvy[GhnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVY1PjdpPkKxNlk3PDZ5PD;hQi=>
NCI-N87 MojsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MmXWPVYhcA>? NVfYUnJtUUN3MDC9JFAvODB3OTFOwG0> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkS2O{c,OjF{OU[0Olc9N2F-
MCF7 NGL6PYZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MonRPVYhcA>? NH6zSndKSzVyIE2gNE4xOjB3IN88US=> M3PtVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm2OFY4Lz5{MUK5OlQ3PzxxYU6=
HeLa Mn72RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NITxXGM6PiCq NXzCcmhPUUN3MDC9JFAvOSEQvF2= Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OU[0OlcoRjJzMkm2OFY4RC:jPh?=
PANC1 Mk\zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkPKPVYhcA>? NIrFVHFKSzVyIE2gNE4{QDRzIN88US=> NWXOenZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVY1PjdpPkKxNlk3PDZ5PD;hQi=>
Bel7402 M4iySWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHnTeJA6PiCq MUDJR|UxKD1iMD61O|gzKM7:TR?= NXfkc3ppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVY1PjdpPkKxNlk3PDZ5PD;hQi=>
1A9 NFPqOmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NEjzVmU{KGSjeYO= M{X5eGVFPTBiPTCwMlAxOjB7IN88US=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkW3PUc,OjF{OU[1O|k9N2F-
A549 M3XONGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MXmzJIRigXN? NI\JW|VGTDVyIE2gNE4xODJ3NjFOwG0> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkW3PUc,OjF{OU[1O|k9N2F-
KB Mnq5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M{fwTVMh\GG7cx?= MXvFSFUxKD1iMD6wNFI5PyEQvF2= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkW3PUc,OjF{OU[1O|k9N2F-
PC3 MkOyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MkDlN{Bl[Xm| M{jrNGVFPTBiPTCwMlAxQDh5IN88US=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NkW3PUc,OjF{OU[1O|k9N2F-
KB NFrhVm1EgXSxdH;4bYNqfHliYYPzZZk> NWrzbmpRPzJiaB?= MojHS2k2OCB;IECuNFA1QDdizszN NFHSbGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOlk4Pyd-MkGzNVY6Pzd:L3G+
DU145 NW\jWHFiS3m2b4TvfIlkcXS7IHHzd4F6 NUKzXoR[PzJiaB?= MVrHTVUxKD1iMD6wNFU2PSEQvF2= M2[wdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{G2PVc4Lz5{MUOxOlk4PzxxYU6=
A549 MonLR5l1d3SxeHnjbZR6KGG|c3H5 NXjRdWVIPzJiaB?= M1HjbmdKPTBiPTCwMlAxPTV6IN88US=> NEmxTZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOxOlk4Pyd-MkGzNVY6Pzd:L3G+
MES-SA MUnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYDlb2VvUUN3MDC9JFAvODB{OU[g{txO MoexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|MkS2PFYoRjJzM{K0Olg3RC:jPh?=
MES-SA M1y4cGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NH;1T3ZKSzVyIE2gNE4xODJ7NjFOwG0> NF7yOYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOyOFY5Pyd-MkGzNlQ3QDd:L3G+
SF295 NI\GOXpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MkfpTWM2OCB;IECuNFI1PTVizszN NYLqPI41RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzNlQ3QDdpPkKxN|I1Pjh5PD;hQi=>
MES-SA MoT0R5l1d3SxeHnjbZR6KGG|c3H5 NHLXN2FKSzVyIE2gNE4xODJ7NjFOwG0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN{NE[5Nkc,OjF|MkS2PVI9N2F-
MCF7 NV3SXHkyS3m2b4TvfIlkcXS7IHHzd4F6 NXrEbGVpPDhiaB?= NVXkcWVTUUN3MDC9JFAvODB4IN88US=> NEjTdnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO0NVcyQCd-MkGzOFE4OTh:L3G+
HT-29 MlHvR5l1d3SxeHnjbZR6KGG|c3H5 MlXYOFghcA>? MkTJTWM2OCB;IECuNFA4KM7:TR?= Mo\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NEG3NVgoRjJzM{SxO|E5RC:jPh?=
K562 M32wVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4DIUFQ5KGh? MX3JR|UxKD1iMT6xOkDPxE1? MknzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NEK3N|UoRjJzM{SyO|M2RC:jPh?=
MCF7 NITlT2lEgXSxdH;4bYNqfHliYYPzZZk> M4PNRlQ5KGh? Ml3hTWM2OCB;IEKuNVEh|ryP MlXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NEK3N|UoRjJzM{SyO|M2RC:jPh?=
A549 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MmPqOFghcA>? NGfUN29KSzVyIE2gNk41PiEQvF2= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN2MkezOUc,OjF|NEK3N|U9N2F-
SGC MWXDfZRwfG:6aXPpeJkh[XO|YYm= NVr2e3dOPDhiaB?= NUmzfGZFUUN3MDC9JFMvOzRizszN M3;2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{SyO|M2Lz5{MUO0Nlc{PTxxYU6=
HCT116 NH[0N3NEgXSxdH;4bYNqfHliYYPzZZk> M1OzSFQ5KGh? MmL4TWM2OCB;IESuN|ch|ryP NEPlXJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO0Nlc{PSd-MkGzOFI4OzV:L3G+
multidrug-resistant K562 MVfDfZRwfG:6aXPpeJkh[XO|YYm= NV7lUnFRPDhiaB?= MXrJR|UxKD1iNT62N{DPxE1? MnjYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NEK3N|UoRjJzM{SyO|M2RC:jPh?=
CCRF-CEM NGjleItEgXSxdH;4bYNqfHliYYPzZZk> NVnGSVdzPzJiaB?= M1fJbWlEPTBiPTCwMlAxOyEQvF2= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN3NkW5Nkc,OjF|NU[1PVI9N2F-
taxol-resistant CCRF-CEM MmfiR5l1d3SxeHnjbZR6KGG|c3H5 MoDxO|IhcA>? MmHMTWM2OCB;IECuOFMh|ryP NIH4bXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO1OlU6Oid-MkGzOVY2QTJ:L3G+
vinblastine-resistant CCRF-CEM NEjXZVFEgXSxdH;4bYNqfHliYYPzZZk> M{LqO|czKGh? NHjUeWRKSzVyIE2gNU4zPyEQvF2= Mki0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NU[1PVIoRjJzM{W2OVkzRC:jPh?=
KB M2CzWmN6fG:2b4jpZ4l1gSCjc4PhfS=> M2PTfVMh\GG7cx?= NWHT[XRST0l3MDC9JFAvODB3MU[g{txO NF6ydoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3O|M3QCd-MkGzO|c{Pjh:L3G+
DU145 MX;DfZRwfG:6aXPpeJkh[XO|YYm= MnryN{Bl[Xm| MUjHTVUxKD1iMD6wNFUzOyEQvF2= NIPyfpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3O|M3QCd-MkGzO|c{Pjh:L3G+
A549 NH3QOWVEgXSxdH;4bYNqfHliYYPzZZk> MWizJIRigXN? NFnYRZFIUTVyIE2gNE4xODd4IN88US=> M{PjR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{e3N|Y5Lz5{MUO3O|M3QDxxYU6=
A2780 Mn3UR5l1d3SxeHnjbZR6KGG|c3H5 NFX1cWozPCCq NUHS[FVkUUN3MDC9JFAvODByOEKg{txO MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN7Nke0O{c,OjF|OU[3OFc9N2F-
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taxol-resistant A549-T12 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MonyO|IhcA>? NXHEc|lzUUN3MDC9JFAvODd3MjFOwG0> NILrdWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[2N|MyQSd-MkG2OlM{OTl:L3G+
MCF7 NGjmUZlEgXSxdH;4bYNqfHliYYPzZZk> NFuwXXM1QCCq NX;PNIhzUUN3MDC9JFAvODB{NTFOwG0> NXvQN3dURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2PFAyQTBpPkKxOlgxOTlyPD;hQi=>
MCF7/VP MYHDfZRwfG:6aXPpeJkh[XO|YYm= MlvCOFghcA>? MmTSTWM2OCB;IECuNFAzQCEQvF2= M1[wblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkiwNVkxLz5{MU[4NFE6ODxxYU6=
NCI/ADR NEC0TlNEgXSxdH;4bYNqfHliYYPzZZk> NX7uW3hSPDhiaB?= M4G0VWlEPTBiPTCyMlch|ryP M{\4V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkiwNVkxLz5{MU[4NFE6ODxxYU6=
LT12 MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NH7LT|A1QCCq M3exT2lEPTBiPTCwMlAxPiEQvF2= M4r2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C1NlI{Lz5{MUewOVIzOzxxYU6=
NCI-H460 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NUD2UmRwPDhiaB?= M1PVbmlEPTBiPTCwMlAyKM7:TR?= NI\RS|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
SF268 MUnDfZRwfG:6aXPpeJkh[XO|YYm= M17rclQ5KGh? NILFWGtKSzVyIE2gNE4xOSEQvF2= M4rzVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C1NlI{Lz5{MUewOVIzOzxxYU6=
KB/HeLa NIHQS2tEgXSxdH;4bYNqfHliYYPzZZk> NVfycJFzPDhiaB?= MYTJR|UxKD1iMD6wNUDPxE1? NIfaTpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
SKOV3 M2\pdWN6fG:2b4jpZ4l1gSCjc4PhfS=> NHPvbGI1QCCq NHjlcXdKSzVyIE2gNE4xOSEQvF2= NIPx[GE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
RKOp27 NWmwW4xnS3m2b4TvfIlkcXS7IHHzd4F6 MV60PEBp MknxTWM2OCB;IECuNFEh|ryP NHXzZo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUewOVIzOyd-MkG3NFUzOjN:L3G+
P388 M3TCSmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MWG0PEBp NH6zc3RKSzVyIE2gNE4xPCEQvF2= MkDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MEWyNlMoRjJzN{C1NlI{RC:jPh?=
L1210 Mlf4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MmfyOFghcA>? NGT1[GFKSzVyIE2gNE4xPiEQvF2= M4\pRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{C1NlI{Lz5{MUewOVIzOzxxYU6=
NCI-H460 M3X2emFvfGmlYX7j[ZIh[XO|YYm= NFHDflU4OiCq MmfGTWM{OCB;IEOuOkDPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdyN{C0Okc,OjF5MEewOFY9N2F-
A2780 MoDvR5l1d3SxeHnjbZR6KGG|c3H5 NEO3R|E1QCCq NF70S3dKSzVyIE2gNE4xODB4MjFOwG0> MljiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5NkSzNFgoRjJzN{[0N|A5RC:jPh?=
A2780AD Mm\PR5l1d3SxeHnjbZR6KGG|c3H5 MkO2OFghcA>? NGfybHJKSzVyIE2gNU46KM7:TR?= M4DUNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{[0N|A5Lz5{MUe2OFMxQDxxYU6=
786-0 NVrxSHZOSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1;VZWlEPTBiPTCwMlAxPCEQvF2= M1;FVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e0OFk6Lz5{MUe3OFQ6QTxxYU6=
PC3 M1vnVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mmj6TWM2OCB;IECuNFAxPDNizszN MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd5NUG1NEc,OjF5N{WxOVA9N2F-
DU145 NUDnTHZbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVPJR|UxKD1iMD6wNFI{KM7:TR?= M{fJRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e1NVUxLz5{MUe3OVE2ODxxYU6=
MDA-MB-435 MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? Moe5TWM2OCB;IECuNFE3KM7:TR?= NFrsUmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OVE2OCd-MkG3O|UyPTB:L3G+
MCF7 NXjYNpdFS3m2b4TvfIlkcXS7IHHzd4F6 M1rIWVQ5KGh? Mlq4TWM2OCB;IECuNFAyPjJizszN MnHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5N{m1NVkoRjJzN{e5OVE6RC:jPh?=
COLO205 NXvXZoZpS3m2b4TvfIlkcXS7IHHzd4F6 MUW0PEBp Mn\tTWM2OCB;IECuNFA{OzFizszN M{fRc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e5OVE6Lz5{MUe3PVUyQTxxYU6=
KB Mn7PR5l1d3SxeHnjbZR6KGG|c3H5 NH\ZSZpKSzVyIE2gOk43QDRizszN NYD3PIJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3PFQ3OzFpPkKxO|g1PjNzPD;hQi=>
DU145 MVvDfZRwfG:6aXPpeJkh[XO|YYm= MnnKTWM2OCB;IEiuOlI3KM7:TR?= MoC3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5OES2N|EoRjJzN{i0OlMyRC:jPh?=
A549 NEPybFBEgXSxdH;4bYNqfHliYYPzZZk> NXzCc5RZUUN3MDC9JFkvOjZ3IN88US=> M3PQ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{i0OlMyLz5{MUe4OFY{OTxxYU6=
HeLa MlWxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NX3FdnBMUUN3MDC9JFAvODBzM{ig{txO MlnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5OE[3PVMoRjJzN{i2O|k{RC:jPh?=
SKOV3 NGjIeXpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2niU2lEPTBiPTCwMlAxOjl3IN88US=> NXLVOGdGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3PFY4QTNpPkKxO|g3Pzl|PD;hQi=>
HeLa M3uwdmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mkm4OFghcA>? MknTTWM2OCB;IECuNFAyOiEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThyMEizPUc,OjF6MEC4N|k9N2F-
A2780 M1KxV2N6fG:2b4jpZ4l1gSCjc4PhfS=> MknaNkBl[Xm| NHfO[nZKSzVyIE2gNE4xOTRizszN MmXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MEK5OVcoRjJzOECyPVU4RC:jPh?=
Hep3B2 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MYe3NkBp NYDWWmVEUUN3MDC9JFAvODByMEG2JO69VQ>? NH\6N3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQyOCd-MkG4NVI1OTB:L3G+
PANC1 NHXKfpVEgXSxdH;4bYNqfHliYYPzZZk> NIPRSG44OiCq NELjPItKSzVyIE2gNE4xODFzIN88US=> M1X2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEGyOFExLz5{MUixNlQyODxxYU6=
CNE1-LMP1 MXHDfZRwfG:6aXPpeJkh[XO|YYm= M3fMTFczKGh? M33BT2lEPTBiPTCwMlAxPDJizszN MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSxNEc,OjF6MUK0NVA9N2F-
MGC MVHDfZRwfG:6aXPpeJkh[XO|YYm= MnrXO|IhcA>? MVHJR|UxKD1iMD6wNFY1KM7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSxNEc,OjF6MUK0NVA9N2F-
A375 MVXDfZRwfG:6aXPpeJkh[XO|YYm= M3\ZS|czKGh? NULQeYF1UUN3MDC9JFAvODB6OTFOwG0> MljFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NVAoRjJzOEGyOFExRC:jPh?=
MCF7 MV;DfZRwfG:6aXPpeJkh[XO|YYm= Mmf1O|IhcA>? NYL0eot7UUN3MDC9JFAvODF2IN88US=> MmjIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NVAoRjJzOEGyOFExRC:jPh?=
HaCaT Mn;qR5l1d3SxeHnjbZR6KGG|c3H5 MXe3NkBp MUDJR|UxKD1iMD6wNlQh|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSxNEc,OjF6MUK0NVA9N2F-
A549 NXr3cXZoS3m2b4TvfIlkcXS7IHHzd4F6 NX7sd28yPzJiaB?= M{HDfGlEPTBiPTCwMlA{KM7:TR?= NGDrdY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQyOCd-MkG4NVI1OTB:L3G+
EC109 MYLDfZRwfG:6aXPpeJkh[XO|YYm= M2nFXVczKGh? NUPpVpNSUUN3MDC9JFAvOTRizszN NGHJ[Io9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUixNlQyOCd-MkG4NVI1OTB:L3G+
MES-SA Ml\hR5l1d3SxeHnjbZR6KGG|c3H5 MWW5OkBp NFXLPHJKSzVyIE2gNE4xODRizszN MmrNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6MUK0NlEoRjJzOEGyOFIyRC:jPh?=
MES-SA/Dx5 NWTF[ZZkS3m2b4TvfIlkcXS7IHHzd4F6 M3PLZlk3KGh? NGDxdVNKSzVyIE2gNE44PSEQvF2= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOThzMkSyNUc,OjF6MUK0NlE9N2F-
HT-29 MWTDfZRwfG:6aXPpeJkh[XO|YYm= MUjHTVUxKD1iMD6wNFIh|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh|OU[0NEc,OjF6M{m2OFA9N2F-
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HCC2998 MVzDfZRwfG:6aXPpeJkh[XO|YYm= M3W0b2dKPTBiPTCwMlAxOyEQvF2= NVLLbYhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
Hs578T Mn;1R5l1d3SxeHnjbZR6KGG|c3H5 MXPHTVUxKD1iMD6wNFMh|ryP MkHPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6M{m2OFAoRjJzOEO5OlQxRC:jPh?=
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A549 M4LPZ2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYX4RpR7T0l3MDC9JFAvODB2IN88US=> Mnq1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6M{m2OFAoRjJzOEO5OlQxRC:jPh?=
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NCI-H322M MoDvR5l1d3SxeHnjbZR6KGG|c3H5 M2LXZWdKPTBiPTCwMlAyOyEQvF2= NUnte3R3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4N|k3PDBpPkKxPFM6PjRyPD;hQi=>
UACC257 MVfDfZRwfG:6aXPpeJkh[XO|YYm= M2j1PWdKPTBiPTCwMlA1KM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh|OU[0NEc,OjF6M{m2OFA9N2F-
HCT15 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NV\Y[nduT0l3MDC9JFAvOTV6IN88US=> M1fVbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEO5OlQxLz5{MUizPVY1ODxxYU6=
ACHN M2mxN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFHPcVJIUTVyIE2gNE4{QThizszN M2[welxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEO5OlQxLz5{MUizPVY1ODxxYU6=
HL60 M3PQTmN6fG:2b4jpZ4l1gSCjc4PhfS=> NYfzZ3RvPzJiaB?= NHvCO4FKSzVyIE2gNE4xODN2IN88US=> MnrVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6NEiyOlgoRjJzOES4NlY5RC:jPh?=
MCF7 NWnrdZNMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MX25OkBp NFfGfINKSzVyIE2gNE4xODB7MTFOwG0> M2TyUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEewO|k2Lz5{MUi3NFc6PTxxYU6=
A549 NFz5R2tCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M2\4OlczKGh? NEDQZZBKSzVyIE2gNE4xODNzNDFOwG0> NFvsPZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3NFc6PSd-MkG4O|A4QTV:L3G+
A549 MlX4R5l1d3SxeHnjbZR6KGG|c3H5 M2r0SVI1KGh? NX\r[ZNQTUN3MDC9JFAvODB2NjFOwG0> NFrUbos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3N|A3QCd-MkG4O|MxPjh:L3G+
KB NYrQb4VZS3m2b4TvfIlkcXS7IHHzd4F6 NFnTZnlKSzVyIE2gNE4xQCEQvF2= NUPae4h{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
786-0 NWrmfWVTS3m2b4TvfIlkcXS7IHHzd4F6 M3rtXGlEPTBiPTCwMlA5KM7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUe2OEc,OjF6N{W3OlQ9N2F-
OS-RC2 M3X4U2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1rjVWlEPTBiPTCwMlA5KM7:TR?= NHnIXII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3OVc3PCd-MkG4O|U4PjR:L3G+
22Rv1 M1v3XWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3zUOGlEPTBiPTCwMlA5KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh5NUe2OEc,OjF6N{W3OlQ9N2F-
HepG2 MoLiR5l1d3SxeHnjbZR6KGG|c3H5 M3HKS2lEPTBiPTCwMlA5KM7:TR?= NVTPPIRSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
HT-29 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NXi0blV[UUN3MDC9JFAvOzhizszN NIjwNXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi3OVc3PCd-MkG4O|U4PjR:L3G+
A375 NUfISZNWS3m2b4TvfIlkcXS7IHHzd4F6 M1rWbWlEPTBiPTCwMlgyKM7:TR?= NV7QWoxFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
MCF7 NXXYRVFGS3m2b4TvfIlkcXS7IHHzd4F6 NUWwPVRZUUN3MDC9JFEvOyEQvF2= NYnQNVFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|U4PjRpPkKxPFc2PzZ2PD;hQi=>
BGC823 NGDJeFREgXSxdH;4bYNqfHliYYPzZZk> MnjMTWM2OCB;IEGuOUDPxE1? MnHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6N{W3OlQoRjJzOEe1O|Y1RC:jPh?=
769-P NEXJepZEgXSxdH;4bYNqfHliYYPzZZk> MmflTWM2OCB;IEeuNUDPxE1? M{HQZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEe1O|Y1Lz5{MUi3OVc3PDxxYU6=
MCF7 NVXZOYpOS3m2b4TvfIlkcXS7IHHzd4F6 NXLxR5Y{OyCmYYnz M1PTb2dKPTBiPTCxMlA4KM7:TR?= M3LEZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi5N|QyLz5{MUi4PVM1OTxxYU6=
PC3 MUnDfZRwfG:6aXPpeJkh[XO|YYm= NFjFOIk{KGSjeYO= MoXES2k2OCB;IEGuOFYh|ryP M{DUflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi5N|QyLz5{MUi4PVM1OTxxYU6=
SK-N-SH Mn72R5l1d3SxeHnjbZR6KGG|c3H5 M{H6RVMh\GG7cx?= NYXQVJJuT0l3MDC9JFIvOTlizszN M1vOXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi5N|QyLz5{MUi4PVM1OTxxYU6=
HeLa M1zyWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MkCzN{Bl[Xm| MVfHTVUxKD1iMj64NkDPxE1? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh6OUO0NUc,OjF6OEmzOFE9N2F-
CHO-VV 3-2 M13te2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXSxPFM6PDhiaB?= NWfqVlhPUUN3MDC9JFAvOTRizszN NWHjNYJoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NlA3OzhpPkKxPVIxPjN6PD;hQi=>
CHO-TAX 5-6 MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M3Xm[|Q5KGh? NV25Sm5PUUN3MDC9JFAvPTJizszN MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl{ME[zPEc,OjF7MkC2N|g9N2F-
multidrug-resistant CEM/VLB M3ywb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NGKwR5Y1QCCq NFy0flhKSzVyIE2gN{4{PCEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl{ME[zPEc,OjF7MkC2N|g9N2F-
BGC823 M{XzZWN6fG:2b4jpZ4l1gSCjc4PhfS=> M2HvcGlEPTBiPTCwMlAxOzJ7IN88US=> NYLzPXBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5Nlg4QTdpPkKxPVI5Pzl5PD;hQi=>
HT-29 MmD4R5l1d3SxeHnjbZR6KGG|c3H5 MoqyTWM2OCB;IECuNFA{QTRizszN MlXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7Mki3PVcoRjJzOUK4O|k4RC:jPh?=
HepG2 MVXDfZRwfG:6aXPpeJkh[XO|YYm= MVTJR|UxKD1iMD6wNFQ1KM7:TR?= NEPsVnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmyPFc6Pyd-MkG5Nlg4QTd:L3G+
A375 NH7LPWpEgXSxdH;4bYNqfHliYYPzZZk> MoTNTWM2OCB;IECuNFA1QSEQvF2= NI[wU4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmyPFc6Pyd-MkG5Nlg4QTd:L3G+
A549 MV\DfZRwfG:6aXPpeJkh[XO|YYm= MYrJR|UxKD1iMD6wOFQ6KM7:TR?= NVXveol6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5Nlg4QTdpPkKxPVI5Pzl5PD;hQi=>
NCI-H460 Mn\FR5l1d3SxeHnjbZR6KGG|c3H5 M1HoUWlEPTBiPTC4JO69VQ>? NYD3RlA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OFI4PjVpPkKxPVQzPzZ3PD;hQi=>
A549 M3\PWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NFvMT4Q1QCCq NVr0clhnUUN3MDC9JFAvODFizszN NGO3enM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm3N|A2PCd-MkG5O|MxPTR:L3G+
HeLa M4L6OGN6fG:2b4jpZ4l1gSCjc4PhfS=> NX\odFJYPDhiaB?= M2GyXmlEPTBiPTCwMlYh|ryP M3rzUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUezNFU1Lz5{MUm3N|A2PDxxYU6=
HT-29 M13kN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXWzJIRigXN? MoPZSWQ2OCB;IECuNFA3KM7:TR?= M1rQe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUezNVAyLz5{MUm3N|ExOTxxYU6=
HBL100 NEfsRVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1PTN2dKPTBiPTCwMlAxODBzNzFOwG0> NV7ldo1zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5PFY2QDVpPkKxPVg3PTh3PD;hQi=>
HeLa MoHBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLoZ|hDT0l3MDC9JFAvODByMEOzJO69VQ>? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NkW4OUc,OjF7OE[1PFU9N2F-
T47D NHy2VoJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3jKeWdKPTBiPTCwMlAxODF3IN88US=> NH74d5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm4OlU5PSd-MkG5PFY2QDV:L3G+
WiDr M{\4Omdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLHTVUxKD1iMD6wNFAzOiEQvF2= MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NkW4OUc,OjF7OE[1PFU9N2F-
A2780 NV;XSlVTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYnRWnhUT0l3MDC9JFAvODByMkeg{txO NWPDeZI5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5PFY2QDVpPkKxPVg3PTh3PD;hQi=>
SW1573 NX3rWJk{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXPHTVUxKD1iMD6wNFUh|ryP NXnKcXJJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5PFY2QDVpPkKxPVg3PTh3PD;hQi=>
A2780 M4\k[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MnnaTWM2OCB;IECuNFE4KM7:TR?= M{nLRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUm1OVQzLz5{MUm5OVU1OjxxYU6=
A549 NWDqcGJQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NU\IcWNuPzJiaB?= M1;ZRWlEPTBiPTCwMlAxPzJizszN NXLFOm12RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNlcyODBpPkKyNFI4OTByPD;hQi=>
taxol-resistant A549-T12 NFzqOmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWW3NkBp NX;qW|gxUUN3MDC9JFAvODd3IN88US=> MmP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMkexNFAoRjJ{MEK3NVAxRC:jPh?=
OVCAR8 MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MV[5OkBp MnPUTWM2OCB;IECuNFAzKM7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB2NEG2OEc,OjJyNESxOlQ9N2F-
NCI-ADR-RES NVT2UI9JT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4C5b|k3KGh? NHraPFlKSzVyIE2gNU42KM7:TR?= NGqxXIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC0OFE3PCd-MkKwOFQyPjR:L3G+
KB NHnZZXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWK3NkBp NXe3T45yUUN3MDC9JFAvODB|MzFOwG0> NHfhbng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC2NFA{Oyd-MkKwOlAxOzN:L3G+
KB-7d NX7Xb|hVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NG\qNHA4OiCq MoTtTWM2OCB;IECuNFA4QSEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB4MECzN{c,OjJyNkCwN|M9N2F-
KB-S15 NYPmVIw{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHrTPWs4OiCq NXvvNopJUUN3MDC9JFAvOjd|IN88US=> NWfENFBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwOlAxOzNpPkKyNFYxODN|PD;hQi=>
A2780 M{XLUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MknLNkBl[Xm| NIHkNGhKSzVyIE2gNE4xOTVizszN MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB5MUWyOkc,OjJyN{G1NlY9N2F-
KB NYXmVI9rS3m2b4TvfIlkcXS7IHHzd4F6 NX\4U3VnPDhiaB?= NHfzd4xKSzVyIE2gNE4xODR3IN88US=> NEjESGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC3OFI2Pyd-MkKwO|QzPTd:L3G+
L1210 MmfkR5l1d3SxeHnjbZR6KGG|c3H5 MXe0PEBp M3z6b2lEPTBiPTCwMlEzKM7:TR?= MmTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{SyOVcoRjJ{MEe0NlU4RC:jPh?=
A2780 MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M2eyTFIh\GG7cx?= M4DYSGlEPTBiPTCwMlAzKM7:TR?= Mn7SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzM{[1NlMoRjJ{MUO2OVI{RC:jPh?=
DU145 M1fl[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NGH4b4ZGSzVyIE2gNE4xODV7IN88US=> MkPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNEK1OFMoRjJ{MUSyOVQ{RC:jPh?=
KB MknHR5l1d3SxeHnjbZR6KGG|c3H5 NXy0OGlUTUN3MDC9JFAvODB4IN88US=> NVXxWFJlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFI2PDNpPkKyNVQzPTR|PD;hQi=>
A549 MV\DfZRwfG:6aXPpeJkh[XO|YYm= MVLFR|UxKD1iMD6wNFY1KM7:TR?= NXK5PFd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFI2PDNpPkKyNVQzPTR|PD;hQi=>
QGY7701 NYnQUpRHS3m2b4TvfIlkcXS7IHHzd4F6 MkD3O|IhcA>? MXjJR|UxKD1iMD6wOEDPxE1? M3vLS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUWzN|M5Lz5{MkG1N|M{QDxxYU6=
HepG2 MXrDfZRwfG:6aXPpeJkh[XO|YYm= M2TERlczKGh? NX[4N2xbUUN3MDC9JFAvODVizszN MlLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUOzN|goRjJ{MUWzN|M5RC:jPh?=
Bel7404 NWfuXYxMS3m2b4TvfIlkcXS7IHHzd4F6 M2f4UVczKGh? M17RdWlEPTBiPTCwMlgzKM7:TR?= NWn0[4RJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOVM{OzhpPkKyNVU{OzN6PD;hQi=>
SMMC7721 M1zPT2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUG3NkBp MYXJR|UxKD1iMD64PEDPxE1? Mm\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUOzN|goRjJ{MUWzN|M5RC:jPh?=
Bel7402 MXfDfZRwfG:6aXPpeJkh[XO|YYm= NFvoXlA4OiCq MXvJR|UxKD1iMT6yOUDPxE1? Mn3vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUOzN|goRjJ{MUWzN|M5RC:jPh?=
MCF7 NGDJUplEgXSxdH;4bYNqfHliYYPzZZk> MknuNlQhfG9iNEigbC=> NHjSdIFKSzVyIE2gNE4xODNizszN NFzGNXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNlA1OCd-MkKyNlIxPDB:L3G+
SH-SY5Y MUPDfZRwfG:6aXPpeJkh[XO|YYm= NFX6d2QzPCC2bzC0PEBp MlXHTWM2OCB;IECuNFA1KM7:TR?= MkDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkKwOFAoRjJ{MkKyNFQxRC:jPh?=
HepG2 NYC5VHJMS3m2b4TvfIlkcXS7IHHzd4F6 NV62TJE1OjRidH:gOFghcA>? NHfMbYJKSzVyIE2gNE4xODdizszN MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{MkC0NEc,OjJ{MkKwOFA9N2F-
H460 MXTDfZRwfG:6aXPpeJkh[XO|YYm= MWGyOEB1dyB2ODDo MXHJR|UxKD1iMD6wNFgh|ryP NWWzW4o2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlIxPDBpPkKyNlIzODRyPD;hQi=>
HT-29 M3nTbmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVyzJIRigXN? NYTNfZRZUUN3MDC9JFAvODB4IN88US=> NUnRNWJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyN|k3ODFpPkKyNlM6PjBzPD;hQi=>
DU145 NYPxVVJmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NHTqUog4OiCq NGPJVmtIUTVyIE2gNE4xODN6NjFOwG0> MnHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkW2PFUoRjJ{Mk[1Olg2RC:jPh?=
KB NV;JNYd[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MUC3NkBp NH3lbFhIUTVyIE2gNE4xODRzMjFOwG0> MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ4NU[4OUc,OjJ{NkW2PFU9N2F-
A549 NUjXUYF{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NIXWXpQ4OiCq NX7lO4F6T0l3MDC9JFAvODB3NE[g{txO NEP5R|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkK2OVY5PSd-MkKyOlU3QDV:L3G+
MCF7 M2TlWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MoS3PVYhcA>? MlnSTWM2OCB;IECuNUDPxE1? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN4ME[xN{c,OjJ|NkC2NVM9N2F-
A549 NXfEb3BDS3m2b4TvfIlkcXS7IHHzd4F6 NUXyWWVWPzJiaB?= MUPJR|UxKD1iMD6xPUDPxE1? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR5MkC0N{c,OjJ2N{KwOFM9N2F-
MCF7 MVfDfZRwfG:6aXPpeJkh[XO|YYm= NH3UPWY1QCCq NGPTSXZKSzVyIE2gNE4xODZizszN MnHQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2N{KwOFUoRjJ{NEeyNFQ2RC:jPh?=
K562 NIXGUpREgXSxdH;4bYNqfHliYYPzZZk> NYq5SYZsPzJiaB?= MV7JR|UxKD1iMD60NUDPxE1? NI\2XGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|A6OCd-MkK0PFMxQTB:L3G+
CaEs17 MVrDfZRwfG:6aXPpeJkh[XO|YYm= NI\Vb4c4OiCq NEHuR5BKSzVyIE2gNE41OyEQvF2= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR6M{C5NEc,OjJ2OEOwPVA9N2F-
MGC803 NG\jUndEgXSxdH;4bYNqfHliYYPzZZk> NFvB[pM4OiCq NXHCN2cxUUN3MDC9JFAvQDVizszN NE[5fVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|A6OCd-MkK0PFMxQTB:L3G+
HeLa NUXCSoVVS3m2b4TvfIlkcXS7IHHzd4F6 NUW2VZZTPzJiaB?= NV7Bc4t7UUN3MDC9JFAvQDlizszN M4[1RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEizNFkxLz5{MkS4N|A6ODxxYU6=
Bel7402 NXnkU|ZwS3m2b4TvfIlkcXS7IHHzd4F6 MoHRO|IhcA>? M1PtbWlEPTBiPTCxMlg6KM7:TR?= NFfZSnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|A6OCd-MkK0PFMxQTB:L3G+
A549 NEfkdWxEgXSxdH;4bYNqfHliYYPzZZk> NHjPcHc4OiCq MVXJR|UxKD1iMz60OkDPxE1? NVLi[lN1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFMxQTBpPkKyOFg{ODlyPD;hQi=>
MCF7 NGnv[GZEgXSxdH;4bYNqfHliYYPzZZk> NHfye2Q4OiCq MmnkTWM2OCB;IESuO|ch|ryP NHXV[GI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|A6OCd-MkK0PFMxQTB:L3G+
SKOV3 NXTkd5hzS3m2b4TvfIlkcXS7IHHzd4F6 NUDxb5ZmUUN3MDC9JFAvODByMTFOwG0> MmL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3ME[2NlAoRjJ{NUC2OlIxRC:jPh?=
BGC823 NF;CUI9EgXSxdH;4bYNqfHliYYPzZZk> NIXySHFKSzVyIE2gNE4xODN|IN88US=> NFrINJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWwOlYzOCd-MkK1NFY3OjB:L3G+
HepG2 NVTPdGFUS3m2b4TvfIlkcXS7IHHzd4F6 MnS0TWM2OCB;IECuNFA1PCEQvF2= NWHoWJJNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1NFY3OjBpPkKyOVA3PjJyPD;hQi=>
A549 M1;aPGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWrJR|UxKD1iMD6wNVYh|ryP MoXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3ME[2NlAoRjJ{NUC2OlIxRC:jPh?=
HCT8 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NE\BWphKSzVyIE2gNE4xPTFizszN M{S4TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUC2OlIxLz5{MkWwOlYzODxxYU6=
CCRF-CEM MnK4R5l1d3SxeHnjbZR6KGG|c3H5 MkDTO|IhcA>? MWXJR|UxKD1iMD6wNFEzKM7:TR?= M3\GZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUC3PFk{Lz5{MkWwO|g6OzxxYU6=
taxol-resistant CCRF-CEM M3ToemN6fG:2b4jpZ4l1gSCjc4PhfS=> MY[3NkBp M1\PNWlEPTBiPTCwMlQ{KM7:TR?= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVyN{i5N{c,OjJ3MEe4PVM9N2F-
vinblastine-resistant CCRF-CEM NEHvUYFEgXSxdH;4bYNqfHliYYPzZZk> NHHUO|E4OiCq MWHJR|UxKD1iMT6yO{DPxE1? NELUPZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWwO|g6Oyd-MkK1NFc5QTN:L3G+
BGC823 NHH0fYZEgXSxdH;4bYNqfHliYYPzZZk> M4f4SVczKGh? M1P3TGlEPTBiPTCwMlAxOSEQvF2= MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV6M{C3PUc,OjJ3OEOwO|k9N2F-
A2780 NHy1bXVEgXSxdH;4bYNqfHliYYPzZZk> MUi3NkBp NWj3e2NbUUN3MDC9JFAvODBzIN88US=> NGixe|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4N|A4QSd-MkK1PFMxPzl:L3G+
Bel7402 M3jYWWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEHCUII4OiCq MVjJR|UxKD1iMD6wNFYh|ryP MnizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3OEOwO|koRjJ{NUizNFc6RC:jPh?=
A549 MlzCR5l1d3SxeHnjbZR6KGG|c3H5 NYrvOoZCPzJiaB?= MYHJR|UxKD1iMD6wNVYh|ryP NVnmR3ZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1PFMxPzlpPkKyOVg{ODd7PD;hQi=>
HCT8 NHTVfHpEgXSxdH;4bYNqfHliYYPzZZk> NXzlU5QxPzJiaB?= M4\vdGlEPTBiPTCwMlA2OSEQvF2= M2fTV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUizNFc6Lz5{MkW4N|A4QTxxYU6=
MES-SA NGHlWHFEgXSxdH;4bYNqfHliYYPzZZk> NHvGOmE6PiCq MlTsTWM2OCB;IECuNFA1KM7:TR?= M1X2S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUi3OVE6Lz5{MkW4O|UyQTxxYU6=
MESSA/DX5 NX3WOmhbS3m2b4TvfIlkcXS7IHHzd4F6 NVz6d5BYQTZiaB?= Mnm4TWM2OCB;IECuO|Uh|ryP MnrYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3OEe1NVkoRjJ{NUi3OVE6RC:jPh?=
HCT116 NVLsZZpNS3m2b4TvfIlkcXS7IHHzd4F6 Mn6xTWM2OCB;IECuNFUh|ryP MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ7MUG3PUc,OjJ4OUGxO|k9N2F-
SKBR3 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NGPvfFhKSzVyIE2gNE4yOSEQvF2= NVLufW9iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PVEyPzlpPkKyOlkyOTd7PD;hQi=>
SK-MEL-5 M1\keGN6fG:2b4jpZ4l1gSCjc4PhfS=> MV3JR|UxKD1iMD6xOUDPxE1? NEXGNZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[5NVE4QSd-MkK2PVEyPzl:L3G+
SKOV3 NHTNRpFEgXSxdH;4bYNqfHliYYPzZZk> NX\lb3E2UUN3MDC9JFAvPCEQvF2= NUXGVmV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PVEyPzlpPkKyOlkyOTd7PD;hQi=>
MCF7 NGfQRWdEgXSxdH;4bYNqfHliYYPzZZk> NUT2cGJ2UUN3MDC9JFAvQSEQvF2= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ7MUG3PUc,OjJ4OUGxO|k9N2F-
PC3 NH\sVY9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M33PflQ5KGh? NIfWOZVKSzVyIE2gNE4xODB2IN88US=> Mln4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5OEO5OVQoRjJ{N{izPVU1RC:jPh?=
paclitaxel-resistant PC3-TxR M37OdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NYm4bpA6PDhiaB?= NF;jbI1KSzVyIE2gNE4yQDhizszN MkX2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5OEO5OVQoRjJ{N{izPVU1RC:jPh?=
MCF7 NYf1Rpo6S3m2b4TvfIlkcXS7IHHzd4F6 NHHH[3czPCCq M3HOWGlEPTBiPTCwMlAyPSEQvF2= M1nDO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEG4NFgyLz5{MkixPFA5OTxxYU6=
SKBR3 NHLVXVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXK0PEBp MV;JR|UxKD1iMD6wNFE6KM7:TR?= M1O0elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEWwNlE1Lz5{Mki1NFIyPDxxYU6=
HepG2 MXXDfZRwfG:6aXPpeJkh[XO|YYm= M3;D[|czKGh? NED4NW1KSzVyIE2gNE4xODB2NDFOwG0> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh5MUKxO{c,OjJ6N{GyNVc9N2F-
MCF7 M3v0fWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3LwS|czKGh? MXTJR|UxKD1iMD6wNFMh|ryP M1u5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEexNlE4Lz5{Mki3NVIyPzxxYU6=
A375 NGPPSI9EgXSxdH;4bYNqfHliYYPzZZk> NH\1UW44OiCq NHXRdYdKSzVyIE2gNE4xODl{IN88US=> Ml;aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6N{GyNVcoRjJ{OEexNlE4RC:jPh?=
BxPC3 NXrlOolLS3m2b4TvfIlkcXS7IHHzd4F6 Mn\PO|IhcA>? M1nZeWlEPTBiPTCwMlA6KM7:TR?= NH3Gdnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki3NVIyPyd-MkK4O|EzOTd:L3G+
SMMC7721 NYXuTlY6S3m2b4TvfIlkcXS7IHHzd4F6 MlewO|IhcA>? NFmzOHdKSzVyIE2gNE4yPSEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh5MUKxO{c,OjJ6N{GyNVc9N2F-
PANC1 Mm\rR5l1d3SxeHnjbZR6KGG|c3H5 MYK3NkBp NEn0fJlKSzVyIE2gNE4zPiEQvF2= MmL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6N{GyNVcoRjJ{OEexNlE4RC:jPh?=
A549 NWXXUpc3S3m2b4TvfIlkcXS7IHHzd4F6 NYrkZmtqPzJiaB?= NW\BZlg3UUN3MDC9JFAvPzJizszN MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh5MUKxO{c,OjJ6N{GyNVc9N2F-
AGS M4T4bmN6fG:2b4jpZ4l1gSCjc4PhfS=> NH7EWm84OiCq NHPCbHNKSzVyIE2gNU43KM7:TR?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh5MUKxO{c,OjJ6N{GyNVc9N2F-
NCI-H2126 NUjG[oN[S3m2b4TvfIlkcXS7IHHzd4F6 NVvSTWc5PzJiaB?= NGXEXo5KSzVyIE2gNk42KM7:TR?= NWO1SJZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK4O|EzOTdpPkKyPFcyOjF5PD;hQi=>
MDA-MB-231 MXTDfZRwfG:6aXPpeJkh[XO|YYm= NGDFR5M4OiCq NHPoTWlKSzVyIE2gOUDPxE1? MkXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6N{GyNVcoRjJ{OEexNlE4RC:jPh?=
U87 NXnYc4xVS3m2b4TvfIlkcXS7IHHzd4F6 MmewO|IhcA>? M3ywbmlEPTBiPTC4MlEh|ryP M1L2bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEexNlE4Lz5{Mki3NVIyPzxxYU6=
HELF NVeyNmpPS3m2b4TvfIlkcXS7IHHzd4F6 MoDUNlQhcA>? NYnJUHBzUUN3MDC9JFcvOTRizszN MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7MEG0NVAoRjJ{OUCxOFExRC:jPh?=
BGC MVzDfZRwfG:6aXPpeJkh[XO|YYm= Mn3FNlQhcA>? NYPVToQ4UUN3MDC9JFkvOjZizszN NXnJ[INYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NFE1OTBpPkKyPVAyPDFyPD;hQi=>
HELF MojiR5l1d3SxeHnjbZR6KGG|c3H5 M4XBd|I1KGh? NGDDdFVKSzVyIE2gO{4yPCEQvF2= M2LoPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUKxPVY3Lz5{MkmyNVk3PjxxYU6=
BGC M17ofGN6fG:2b4jpZ4l1gSCjc4PhfS=> NIDzVnYzPCCq MlPZTWM2OCB;IEmuNlYh|ryP NU\KOGQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlE6PjZpPkKyPVIyQTZ4PD;hQi=>
DU145 MVTDfZRwfG:6aXPpeJkh[XO|YYm= NGjmcoQ4OiCq NUTiV4EyT0l3MDC9JFAvODB{NUWg{txO NXjkfnN5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5N|I{OTNpPkKyPVMzOzF|PD;hQi=>
KB MorhR5l1d3SxeHnjbZR6KGG|c3H5 MlLiO|IhcA>? Mm[4S2k2OCB;IECuNFAzPjVizszN MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|MkOxN{c,OjJ7M{KzNVM9N2F-
A549 MmrBR5l1d3SxeHnjbZR6KGG|c3H5 NETmW2g4OiCq NXzSem5{T0l3MDC9JFAvODB2OEmg{txO MoTCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{KzNVMoRjJ{OUOyN|E{RC:jPh?=
KBVIN M4HKR2N6fG:2b4jpZ4l1gSCjc4PhfS=> M33QdFczKGh? MXrHTVUxKD1iMD65OFgh|ryP MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|MkOxN{c,OjJ7M{KzNVM9N2F-
HL60 MV3DfZRwfG:6aXPpeJkh[XO|YYm= MX:3NkBp NEHVUmlKSzVyIE2gNE4xODJ6MjFOwG0> Mn;2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7NUm1NVgoRjJ{OUW5OVE5RC:jPh?=
HeLa MmDKR5l1d3SxeHnjbZR6KGG|c3H5 MWS3NkBp NYDOSYoyUUN3MDC9JFAvODB{OUOg{txO NVLyUVJjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5OVk2OThpPkKyPVU6PTF6PD;hQi=>
U937 MoX5R5l1d3SxeHnjbZR6KGG|c3H5 MX63NkBp NWm5e2ZUUUN3MDC9JFAvODB|M{eg{txO MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl3OUWxPEc,OjJ7NUm1NVg9N2F-
HeLa M2HaeGN6fG:2b4jpZ4l1gSCjc4PhfS=> MUfJR|UxKD1iMTFOwG0> M37BU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUCzNFk4Lz5{M{GwN|A6PzxxYU6=
A2780 NFT5OJREgXSxdH;4bYNqfHliYYPzZZk> MkC0TWM2OCB;IEGuNUDPxE1? NWjDUXB1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxNFMxQTdpPkKzNVA{ODl5PD;hQi=>
A549 Mo\MRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4L1SlczKGh? NEHt[ZhKSzVyIE2gNE4xODd{IN88US=> NXfuWY1YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxNVcyPzFpPkKzNVE4OTdzPD;hQi=>
taxol-resistant A549-T12 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MX[3NkBp NIfpPJNKSzVyIE2gNE4xPzV{IN88US=> NVz2fW8xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxNVcyPzFpPkKzNVE4OTdzPD;hQi=>
IGROV1/Pt1 MnXrR5l1d3SxeHnjbZR6KGG|c3H5 NGTwSII4OiCq NEniNG9KSzVyIE2gNE4xODJ{IN88US=> M2D6VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUSwN|U5Lz5{M{G0NFM2QDxxYU6=
SKOV3 NHK3UVlEgXSxdH;4bYNqfHliYYPzZZk> MXK3NkBp M37RSGlEPTBiPTCwMlAxOjdizszN M3TSOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUSwN|U5Lz5{M{G0NFM2QDxxYU6=
U2OS M4D6R2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3LwWlczKGh? MX7JR|UxKD1iMD6wNFM1KM7:TR?= NXfXbnByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOFA{PThpPkKzNVQxOzV6PD;hQi=>
PANC1 MUPDfZRwfG:6aXPpeJkh[XO|YYm= M3rY[|czKGh? MVHJR|UxKD1iMD6wNFUzKM7:TR?= NHvI[I89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G0NFM2QCd-MkOxOFA{PTh:L3G+
MIAPaCa2 NIq3O|ZEgXSxdH;4bYNqfHliYYPzZZk> MoT5O|IhcA>? NYXY[YlDUUN3MDC9JFAvODB5MjFOwG0> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF2MEO1PEc,OjNzNECzOVg9N2F-
IGROV1 NWX3Ro1IS3m2b4TvfIlkcXS7IHHzd4F6 NEPtZnE4OiCq NYjnZ5hvUUN3MDC9JFAvODJ|IN88US=> M1XyS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUSwN|U5Lz5{M{G0NFM2QDxxYU6=
MES-SA NH3kVnNEgXSxdH;4bYNqfHliYYPzZZk> MoXxTWM2OCB;IECuNFA{KM7:TR?= MmjJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNEG5NVYoRjJ|MUSxPVE3RC:jPh?=
A2780 NXzZeFh3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M4K4OVIh\GG7cx?= NWrRO5BlUUN3MDC9JFAvODJ6IN88US=> MnP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzNEmzNFQoRjJ|MUS5N|A1RC:jPh?=
MDA-MB-231 M1XNPGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4XjT|czKGh? MYjJR|UxKD1iMD6wOVIh|ryP NGXHXG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N|M6Pyd-MkOxOVM{QTd:L3G+
HepG2 M17GdGN6fG:2b4jpZ4l1gSCjc4PhfS=> NUHjTVVEPzJiaB?= M4DQ[WlEPTBiPTCwMlA2PCEQvF2= NV[ybmF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOVM{QTdpPkKzNVU{Ozl5PD;hQi=>
A549 NITvXFNEgXSxdH;4bYNqfHliYYPzZZk> NGTXUXI4OiCq Mn[xTWM2OCB;IECuNFU3KM7:TR?= NFvQNZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G1N|M6Pyd-MkOxOVM{QTd:L3G+
NUGC3 M1[ybGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfmSlQ{T0l3MDC9JFAvODJizszN NWXkfY43RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxOlc3OTRpPkKzNVY4PjF2PD;hQi=>
HONE1 NYHL[YE6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWDHTVUxKD1iMD6wNkDPxE1? M3rMPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MU[3OlE1Lz5{M{G2O|YyPDxxYU6=
NCI-H460 NYTvcFRzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVnRU4RvT0l3MDC9JFAvODNizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF4N{[xOEc,OjNzNke2NVQ9N2F-
MCF7 MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVXHTVUxKD1iMD6wN{DPxE1? NFjrNZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G2O|YyPCd-MkOxOlc3OTR:L3G+
A549 NXjxO3hDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmnGS2k2OCB;IECuNFYh|ryP M1:zSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MU[3OlE1Lz5{M{G2O|YyPDxxYU6=
HepG2 NFjNZ4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVHiTWdJT0l3MDC9JFAvOThizszN M4fsOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MU[3OlE1Lz5{M{G2O|YyPDxxYU6=
HeLa MXTDfZRwfG:6aXPpeJkh[XO|YYm= NVPF[YpjQTZiaB?= MVPJR|UxKD1iMD6wNFEh|ryP NG\lV289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G3OlYzQCd-MkOxO|Y3Ojh:L3G+
SW780 MUPDfZRwfG:6aXPpeJkh[XO|YYm= NVfqUJk4QTZiaB?= NGrF[GJKSzVyIE2gNE4xODFzIN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF5Nk[yPEc,OjNzN{[2Nlg9N2F-
MESSA MXzDfZRwfG:6aXPpeJkh[XO|YYm= NEH2SZc4OiCq M2nSdWlEPTBiPTCwMlAxPCEQvF2= NGC4OlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KxOFQ2Oid-MkOyNVQ1PTJ:L3G+
OVCAR8 M2DocGN6fG:2b4jpZ4l1gSCjc4PhfS=> NVvITYNmUUN3MDC9JFAvODB3IN88US=> NIfDSZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KxOFQ2Oid-MkOyNVQ1PTJ:L3G+
HeLa MWHDfZRwfG:6aXPpeJkh[XO|YYm= MXu0PEBp Ml\5TWM2OCB;IECuNFA2KM7:TR?= NVvhU5Z6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNVQ1PTJpPkKzNlE1PDV{PD;hQi=>
A549 M1KwPWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlTlOFghcA>? MoOwTWM2OCB;IECuNFA4KM7:TR?= NVvoWGFrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyNVQ1PTJpPkKzNlE1PDV{PD;hQi=>
HT-29 NUHmUIQ{S3m2b4TvfIlkcXS7IHHzd4F6 M1XTPVQ5KGh? M{T6XGlEPTBiPTCwMlAxQCEQvF2= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNES1Nkc,OjN{MUS0OVI9N2F-
HCT15 NWfx[GpMS3m2b4TvfIlkcXS7IHHzd4F6 NE\CXVg4OiCq MlrkTWM2OCB;IECuNFkh|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNES1Nkc,OjN{MUS0OVI9N2F-
MESSA/DX5 Mm\tR5l1d3SxeHnjbZR6KGG|c3H5 MkW1O|IhcA>? MWjJR|UxKD1iMT63OlQh|ryP M3ezblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkG0OFUzLz5{M{KxOFQ2OjxxYU6=
NCI/ADR-RES MYHDfZRwfG:6aXPpeJkh[XO|YYm= NFnhVFNKSzVyIE2gN{4{KM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJzNES1Nkc,OjN{MUS0OVI9N2F-
DU145 NGrlW3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYXHTVUxKD1iMD6wNFY2KM7:TR?= MoX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{N{SxNlMoRjJ|Mke0NVI{RC:jPh?=
KB M2jTTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXjHTVUxKD1iMD6wNFc4PyEQvF2= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ5NEGyN{c,OjN{N{SxNlM9N2F-
A549 MnXWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2jINGdKPTBiPTCwMlAxQDF6IN88US=> NXPNfJhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyO|QyOjNpPkKzNlc1OTJ|PD;hQi=>
KBVIN NHPlbJZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXL4bVVrT0l3MDC9JFEvQDB|IN88US=> M3TjR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mke0NVI{Lz5{M{K3OFEzOzxxYU6=
K562 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NGfOOotKSzVyIE2gNE41OSEQvF2= Mm\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{N{S1O|AoRjJ|Mke0OVcxRC:jPh?=
CaEs17 MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M{WxeGlEPTBiPTCwMlQ{KM7:TR?= M3HuW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mke0OVcxLz5{M{K3OFU4ODxxYU6=
MGC803 NWnYfHVISW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVLGc4k5UUN3MDC9JFAvQDVizszN Ml7SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{N{S1O|AoRjJ|Mke0OVcxRC:jPh?=
Bel7402 NYLFZWdSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{TWd2lEPTBiPTCxMlg6KM7:TR?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ5NEW3NEc,OjN{N{S1O|A9N2F-
U937 MV3DfZRwfG:6aXPpeJkh[XO|YYm= M4DPOlczKGh? MojsTWM2OCB;IECuNFAzOyEQvF2= NXz1TXZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
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MES-SA Mn\VS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk\YS2k2OCB;IECuNFA1KM7:TR?= NH32flE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e1NFQ2PSd-MkO3OVA1PTV:L3G+
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MOLT4 MlXWR5l1d3SxeHnjbZR6KGG|c3H5 NE\0eItKSzVyIE2gNE4xODF6IN88US=> NGLvOXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwOlEyOid-MkO4NFYyOTJ:L3G+
U937 M13s[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHHzPIRKSzVyIE2gNE4xODF7IN88US=> MmD1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6ME[xNVIoRjJ|OEC2NVEzRC:jPh?=
BGC823 MkPJR5l1d3SxeHnjbZR6KGG|c3H5 MkP1TWM2OCB;IECuNFA{PSEQvF2= M4HPfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEC2NVEzLz5{M{iwOlEyOjxxYU6=
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SW480 M3rMPWN6fG:2b4jpZ4l1gSCjc4PhfS=> MYq0PEBp M3noZWlEPTBiPTCwMlA1KM7:TR?= NEjHXGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixPVg4OSd-MkO4NVk5PzF:L3G+
A549 NY\5Z454S3m2b4TvfIlkcXS7IHHzd4F6 NH\YTmo1QCCq NILUS5VKSzVyIE2gNU41KM7:TR?= Mn7VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6MUm4O|EoRjJ|OEG5PFcyRC:jPh?=
MCF7 NVvNdldzS3m2b4TvfIlkcXS7IHHzd4F6 NFfsb4E4OiCq MXPHTVUxKD1iMD6wNFMh|ryP M1i1bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEOxPFEyLz5{M{izNVgyOTxxYU6=
HT-29 MW\DfZRwfG:6aXPpeJkh[XO|YYm= M2XmVVczKGh? MonDS2k2OCB;IECuNFA{KM7:TR?= NHfQXVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{izNVgyOSd-MkO4N|E5OTF:L3G+
MDA-MB-231 MVzDfZRwfG:6aXPpeJkh[XO|YYm= MWO3NkBp MX\JR|UxKD1iMTFOwG0> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh2OEG2N{c,OjN6NEixOlM9N2F-
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rat lymphatic endothelial NXTESIh2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVHodFFLPDhiaB?= NUDTS2tXUUN3MDC9JFAvODF6IN88US=> MnvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NUWzN|goRjJ|OEW1N|M5RC:jPh?=
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DU145 MXzDfZRwfG:6aXPpeJkh[XO|YYm= MlnNS2k2OCB;IECuNFA3KM7:TR?= M{DufVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OE[3OlA1Lz5{M{i2O|YxPDxxYU6=
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A549 M1;wNmN6fG:2b4jpZ4l1gSCjc4PhfS=> MV23NkBp MV\JR|UxKD1iMD6wNVQh|ryP MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh6Nk[4Okc,OjN6OE[2PFY9N2F-
HT-29 MX3DfZRwfG:6aXPpeJkh[XO|YYm= M{jFXVczKGh? NGPqPHBKSzVyIE2gNE4xODB4IN88US=> NWTNWo9YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4PVUxOTlpPkKzPFk2ODF7PD;hQi=>
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NCI-H460 MnPWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmDHOFghcA>? NHrlZlBIUTVyIE2gNE4yKM7:TR?= NVvCRm5qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3Nlc1PjRpPkK0O|I4PDZ2PD;hQi=>
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K562 NFzxTZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoPMOFghcA>? MkHSS2k2OCB;IECuNUDPxE1? M3PoZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{K3OFY1Lz5{NEeyO|Q3PDxxYU6=
OVCAR3 MlzuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUDoPHlOPDhiaB?= Mn65S2k2OCB;IECuNkDPxE1? NXHLbpJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3Nlc1PjRpPkK0O|I4PDZ2PD;hQi=>
HepG2 MknyR5l1d3SxeHnjbZR6KGG|c3H5 MX[zJIRigXN? MVrJR|UxKD1iMD6wNFAyQSEQvF2= NH7EO2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe0OVk3QCd-MkS3OFU6Pjh:L3G+
KB MlPIR5l1d3SxeHnjbZR6KGG|c3H5 M2jQOFMh\GG7cx?= M4TlV2lEPTBiPTCwMlAxOzlizszN MlXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5NEW5OlgoRjJ2N{S1PVY5RC:jPh?=
NCI-ADR-RES NETlTppEgXSxdH;4bYNqfHliYYPzZZk> NEH2VmxGSzVyIE2gNE4xOTNizszN MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhyMU[xNEc,OjR6MEG2NVA9N2F-
OVCAR8 M3v6c2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXjm[|M3TUN3MDC9JFAvODF6IN88US=> NHH4ZZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEiwNVYyOCd-MkS4NFE3OTB:L3G+
NALM6 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWC0PEB1dyB5MjDo NFOzT4xKSzVyIE2gNE4xODRzIN88US=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh3MkK4NUc,OjR6NUKyPFE9N2F-
Jurkat NVTGNYhSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NW\YU2tnPDhidH:gO|IhcA>? NV\2cW1pUUN3MDC9JFAvODB2NTFOwG0> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh3MkK4NUc,OjR6NUKyPFE9N2F-
K562 M{DI[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M3fvclQ5KHSxIEeyJIg> MlrCTWM2OCB;IECuNFA2PSEQvF2= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh3MkK4NUc,OjR6NUKyPFE9N2F-
HeLa NG\2R5pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NHzZUnlKSzVyIE2gNE4xODF{MTFOwG0> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
MDA-MB-435 NGHJRWxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NUnuVlN1UUN3MDC9JFAvODBzOUOg{txO MoTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
SKOV3 NV7ZcJpHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NVPHd4l7UUN3MDC9JFAvODB|IN88US=> Ml\EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
SKOV3 M{HmVWN6fG:2b4jpZ4l1gSCjc4PhfS=> NWnaS2ZLT0l3MDC9JFAvODB2NzFOwG0> M4W5VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEmzNlI1Lz5{NEi5N|IzPDxxYU6=
P-gp expressing SKOV3-M6/6 MonlR5l1d3SxeHnjbZR6KGG|c3H5 NHy0OnFIUTVyIE2gNE43KM7:TR?= MknWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUOyNlQoRjJ2OEmzNlI1RC:jPh?=
PC3 NX;JWWx6S3m2b4TvfIlkcXS7IHHzd4F6 M1PWU|k3KGh? M3nhPGlEPTBiPTCwMlAxOjVizszN NX\hdFBrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA1OzdpPkK0PVAxPDN5PD;hQi=>
HeLa MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mk\sPVYhcA>? NW\se2NiUUN3MDC9JFAvODB3MzFOwG0> M2P2bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwPFY2Lz5{NEmwNFg3PTxxYU6=
OVCAR8 NGTBR|ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEjFU3k6PiCq MoTNTWM2OCB;IECuNFEh|ryP NHXMZZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFg3PSd-MkS5NFA5PjV:L3G+
NCI/ADR-RES M3rBRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV7kN4RVQTZiaB?= M4fveGlEPTBiPTC1JO69VQ>? NGDK[oM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFg3PSd-MkS5NFA5PjV:L3G+
MCF7 MV7DfZRwfG:6aXPpeJkh[XO|YYm= MlixO|IhcA>? M324bGlEPTBiPTCwMlA1PSEQvF2= MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{OUO0OEc,OjR7MkmzOFQ9N2F-
HCT116 M{D4cWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnvwO|IhcA>? MlXyTWM2OCB;IECuNFY6KM7:TR?= M{PjO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUK5N|Q1Lz5{NEmyPVM1PDxxYU6=
HepG2 NUPXTmU5S3m2b4TvfIlkcXS7IHHzd4F6 MmK3O|IhcA>? M17RZWlEPTBiPTCwMlA5PCEQvF2= NY\oUXAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5Nlk{PDRpPkK0PVI6OzR2PD;hQi=>
HeLa NHHx[2hEgXSxdH;4bYNqfHliYYPzZZk> M3T3ZlczKGh? MYTJR|UxKD1iMD6wPVYh|ryP NHr4bGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmyPVM1PCd-MkS5Nlk{PDR:L3G+
U251 NUfLXlJIS3m2b4TvfIlkcXS7IHHzd4F6 NFP5fHU4OiCq NHjNcmlKSzVyIE2gNE4yOjhizszN MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl{OUO0OEc,OjR7MkmzOFQ9N2F-
HT-29 NWDn[4J4S3m2b4TvfIlkcXS7IHHzd4F6 MlnaTWM2OCB;IECuNFAyKM7:TR?= MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl|N{KwPUc,OjR7M{eyNFk9N2F-
HT-29 NXXK[|FVSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M{PMcFI1KGGwZDC3NkBp NVnpVZFpUUN3MDC9JFAvOjlizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl2MUGzNEc,OjR7NEGxN|A9N2F-
HeLa M32wVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHf6e5kzPCCjbnSgO|IhcA>? NHjZXZpKSzVyIE2gNE4zQSEQvF2= MkfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NEGxN|AoRjJ2OUSxNVMxRC:jPh?=
Caco2 MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MkDVNlQh[W6mIEeyJIg> M1nvdmlEPTBiPTCwMlMyKM7:TR?= MknzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NEGxN|AoRjJ2OUSxNVMxRC:jPh?=
HL60 NXyzW2RNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NGrMdoQzPCCjbnSgO|IhcA>? M4nEOGlEPTBiPTCwMlMzKM7:TR?= MnizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7NEGxN|AoRjJ2OUSxNVMxRC:jPh?=
MCF7 M2DpZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHXuPFczPCCjbnSgO|IhcA>? NEHrRZBKSzVyIE2gNE4{OyEQvF2= NF6y[lc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm0NVE{OCd-MkS5OFEyOzB:L3G+
Saos2 NXm2b2JESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M3fvZlI1KGGwZDC3NkBp MkWwTWM2OCB;IECuN|Uh|ryP NF[5S5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm0NVE{OCd-MkS5OFEyOzB:L3G+
SKOV3-MDR1-M6/6 NGrWb2NCdnSrY3HuZ4VzKGG|c3H5 NF71WZo1QCCq M4O0emlEPTBiPTCwMlk4KM7:TR?= NYXTS3BbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OFYyPDVpPkK0PVQ3OTR3PD;hQi=>
SKOV3 NWDhT|FrSW62aXPhcoNmeiCjc4PhfS=> M3HJXlQ5KGh? MVjJR|UxKD1iMTFOwG0> NXzyXVdLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OFYyPDVpPkK0PVQ3OTR3PD;hQi=>
MDA435/LCC6 MYrDfZRwfG:6aXPpeJkh[XO|YYm= MnO4OUBl[Xm| MV\JR|UxKD1iMD6wNFI3KM7:TR?= M3fHb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUWyN|c3Lz5{NEm1NlM4PjxxYU6=
MDA435/LCC6MDR MoPtR5l1d3SxeHnjbZR6KGG|c3H5 NGm0Z242KGSjeYO= NXnBOllHUUN3MDC9JFAvOTR7MzFOwG0> M3nyV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUWyN|c3Lz5{NEm1NlM4PjxxYU6=
MCF7 NFLldY9EgXSxdH;4bYNqfHliYYPzZZk> NUP2Um97UUN3MDC9JFAvODBzNTFOwG0> NIDNXYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEm2NFE1Oyd-MkS5OlAyPDN:L3G+
HepG2 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NVq5[nB{UUN3MDC9JFAvODB2NjFOwG0> NYTVU5pvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5OlAyPDNpPkK0PVYxOTR|PD;hQi=>
MDA-MB-231 MVvDfZRwfG:6aXPpeJkh[XO|YYm= M1P1UWlEPTBiPTCwMlAxQDJizszN M2jnS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OU[wNVQ{Lz5{NEm2NFE1OzxxYU6=
HL7702 MlrpR5l1d3SxeHnjbZR6KGG|c3H5 MUTJR|UxKD1iMT6xJO69VQ>? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl4MEG0N{c,OjR7NkCxOFM9N2F-
MCF7 MlrkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVy4Smd4PDhiaB?= MmO4TWM2OCB;IECuNFI2QDFizszN MoXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7OU[xN|YoRjJ2OUm2NVM3RC:jPh?=
HepG2 M2LFRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MlnDOFghcA>? NVrRfFY6UUN3MDC9JFAvODZ5Mkeg{txO M2Dl[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUm2NVM3Lz5{NEm5OlE{PjxxYU6=
A549 MoPCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlvuOFghcA>? MW\JR|UxKD1iMT61NlUh|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7NkGzOkc,OjR7OU[xN|Y9N2F-
KB M4PUdWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3jHVVczKGh? NICwSVJKSzVyIE2gNE4xODN7IN88US=> NXm5UpRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwNFg1PTZpPkK1NFA5PDV4PD;hQi=>
A549 M3jt[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NF;VUnA4OiCq NFTWdplKSzVyIE2gNE4xODV5IN88US=> Ml\OQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMEi0OVYoRjJ3MEC4OFU3RC:jPh?=
MDA-MB-231 MlrMR5l1d3SxeHnjbZR6KGG|c3H5 MlPPO|IhcA>? NEnSd4RKSzVyIE2gNE4xODZ4IN88US=> M{jMbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEC4OFU3Lz5{NUCwPFQ2PjxxYU6=
KBVIN M{C4T2N6fG:2b4jpZ4l1gSCjc4PhfS=> MY[3NkBp MmnRTWM2OCB;IEGuOFQh|ryP MlLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMEi0OVYoRjJ3MEC4OFU3RC:jPh?=
MESSA M2DpNGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2DUWlczKGh? NV63W|NDUUN3MDC9JFAvODB2IN88US=> MnTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMkW5PVEoRjJ3MEK1PVkyRC:jPh?=
OVCAR8 MWPDfZRwfG:6aXPpeJkh[XO|YYm= MVu5OkBp MYHJR|UxKD1iMD6wNFUh|ryP M3jUeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEK1PVkyLz5{NUCyOVk6OTxxYU6=
MESSA/DX5 MUHDfZRwfG:6aXPpeJkh[XO|YYm= M4PsXVczKGh? NYXTbmd[UUN3MDC9JFEvPzZ2IN88US=> NFG0OHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCyOVk6OSd-MkWwNlU6QTF:L3G+
HepG2 MX7DfZRwfG:6aXPpeJkh[XO|YYm= NIH6Z2U1QCCq M1v4XGlEPTBiPTCyMlA{PyEQvF2= M3ThcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEK1PVkyLz5{NUCyOVk6OTxxYU6=
NCI/ADR-RES NITROppEgXSxdH;4bYNqfHliYYPzZZk> NIjJd2U6PiCq NIHNb2VKSzVyIE2gN{4{KM7:TR?= NEH1UIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCyOVk6OSd-MkWwNlU6QTF:L3G+
PC3 MoK4R5l1d3SxeHnjbZR6KGG|c3H5 NFTOSW01QCCq NETOW|lKSzVyIE2gN{46QSEQvF2= MlHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyMkW5PVEoRjJ3MEK1PVkyRC:jPh?=
TCT1 M{LjWGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGL3eXg1QCCq NIfkdWpKSzVyIE2gNk42KM7:TR?= M161eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MES2NVI5Lz5{NUC0OlEzQDxxYU6=
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A549 M3rnRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NISxUIY1QCCq M1nqV2lEPTBiPTCwMlAxPSEQvF2= M3rBO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[xPFA{Lz5{NUC2NVgxOzxxYU6=
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HCT8 NV3Mc5J[SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Ml3ZOFghcA>? NG[0UYFKSzVyIE2gNE4xOjFizszN MknjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyNkG4NFMoRjJ3ME[xPFA{RC:jPh?=
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HepG2 NEn1[|RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mn\LOFghcA>? NYf1TJRtUUN3MDC9JFAvODJ6IN88US=> M2LmT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3ME[xPFA{Lz5{NUC2NVgxOzxxYU6=
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A549 NV3sepN5S3m2b4TvfIlkcXS7IHHzd4F6 Mmr4OFghcA>? MWHJR|UxKD1iMD6wPFIh|ryP M37zU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEi0NVQ1Lz5{NUC4OFE1PDxxYU6=
COLO205 NYHXUGxKS3m2b4TvfIlkcXS7IHHzd4F6 M1[zbmlEPTBiPTCwMlAxOyEQvF2= MojvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOUG5NlYoRjJ3MEmxPVI3RC:jPh?=
K562 NFXaXIZEgXSxdH;4bYNqfHliYYPzZZk> M2\X[VczKGh? MnqyTWM2OCB;IECuNFA1KM7:TR?= M{Hv[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEmxPVI3Lz5{NUC5NVkzPjxxYU6=
A431 MoHsR5l1d3SxeHnjbZR6KGG|c3H5 MXy3NkBp NIX1THpKSzVyIE2gNE4xODdizszN M{HlPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEmxPVI3Lz5{NUC5NVkzPjxxYU6=
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HepG2 MofGR5l1d3SxeHnjbZR6KGG|c3H5 M1LQblczKGh? M2C3[WlEPTBiPTCwMlk6KM7:TR?= NEH3dJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUC5NVkzPid-MkWwPVE6OjZ:L3G+
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NCI-N87 MkTJR5l1d3SxeHnjbZR6KGG|c3H5 NU\VUmViPCCmYYnz MVzJR|UxKD1iMD6wNFc2OyEQvF2= Moq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyOUi1NlgoRjJ3MEm4OVI5RC:jPh?=
NCI-H1975 NGXNe|NEgXSxdH;4bYNqfHliYYPzZZk> MUe0JIRigXN? MV;JR|UxKD1iMD6wNFc6PCEQvF2= NXGwfGZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVg2OjhpPkK1NFk5PTJ6PD;hQi=>
BT474 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NYHnd|RuPCCmYYnz MoLpTWM2OCB;IECuNFA5OzZizszN NVvaNIdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVg2OjhpPkK1NFk5PTJ6PD;hQi=>
DU145 NIPjdlREgXSxdH;4bYNqfHliYYPzZZk> M17aNGlEPTBiPTCxMlUh|ryP NGDV[Vg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGwOVczOid-MkWxNFU4OjJ:L3G+
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HeLa NWrvR|ZIS3m2b4TvfIlkcXS7IHHzd4F6 NXjv[4kyUUN3MDC9JFUh|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTFyNUeyNkc,OjVzMEW3NlI9N2F-
MCF7 NX7wTld5S3m2b4TvfIlkcXS7IHHzd4F6 MUS0PEBp M4K2WGlEPTBiPTCwMlIh|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTF5NkOyPUc,OjVzN{[zNlk9N2F-
NCI-H358 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MoDOOFghcA>? M4qwVGlEPTBiPTCwMlAxOiEQvF2= NUXhToxNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNFg{PDVpPkK1NlA5OzR3PD;hQi=>
A2780S NWLCSG5kSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= Ml7iOFghcA>? NVHNO3VHUUN3MDC9JFAvODB2IN88US=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJyOEO0OUc,OjV{MEizOFU9N2F-
HCT8 MnjwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M1\MTFQ5KGh? NEjIeVNKSzVyIE2gNE4xODVizszN M2nrflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkC4N|Q2Lz5{NUKwPFM1PTxxYU6=
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DLD1 MnzCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYq0PEBp MmT2TWM2OCB;IECuNFE3KM7:TR?= NXjKb|E1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNFg{PDVpPkK1NlA5OzR3PD;hQi=>
HCT116 NWHPXmxYSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXi0PEBp M4PKSWlEPTBiPTCwMlAyQCEQvF2= M2j1e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkC4N|Q2Lz5{NUKwPFM1PTxxYU6=
ES2 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MomzOFghcA>? M3;ZS2lEPTBiPTCwMlAzKM7:TR?= MlTtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MEizOFUoRjJ3MkC4N|Q2RC:jPh?=
U251 M4HFUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MWG0PEBp MonITWM2OCB;IECuNFI{KM7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJyOEO0OUc,OjV{MEizOFU9N2F-
HCT15 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NG\NV4I1QCCq NHfodZlKSzVyIE2gNE4xOjRizszN NIqzS|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKwPFM1PSd-MkWyNFg{PDV:L3G+
HepG2 NFvTUlBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MV60PEBp M3vQWGlEPTBiPTCwMlA{QCEQvF2= NIn4[W09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKwPFM1PSd-MkWyNFg{PDV:L3G+
MCF7 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MYS0PEBp NGjrTXVKSzVyIE2gNE4yOzJizszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJyOEO0OUc,OjV{MEizOFU9N2F-
C26 MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? M331TFQ5KGh? NH7yXHRKSzVyIE2gNE4zOSEQvF2= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJyOEO0OUc,OjV{MEizOFU9N2F-
HL60 NV\CWo83S3m2b4TvfIlkcXS7IHHzd4F6 MkDyOFghcA>? Ml\0TWM2OCB;IEGuOUDPxE1? NEK3W3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKxNVA{Oid-MkWyNVExOzJ:L3G+
K562 NHfWUmdEgXSxdH;4bYNqfHliYYPzZZk> NXi2O|V{PDhiaB?= Mnj5TWM2OCB;IEKuOEDPxE1? NGSxeZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKxNVA{Oid-MkWyNVExOzJ:L3G+
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MES-SA NIHDdmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Mkf3OFghcA>? NXq2SoxOT0l3MDC9JFAvODB5IN88US=> MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ5MUWwNUc,OjV4N{G1NFE9N2F-
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A549 M{TmSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MojhOFghcA>? Mnf2TWM2OCB;IECuNFA{KM7:TR?= MojyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEK1OlEoRjJ3NkiyOVYyRC:jPh?=
MCF7 NEnyTIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NX7pbHFNPDhiaB?= NWf6TWgyUUN3MDC9JFAvODB|IN88US=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ6MkW2NUc,OjV4OEK1OlE9N2F-
A549/CDDP M3m5VWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NWDv[G4{PDhiaB?= MYXJR|UxKD1iMD6wNFYh|ryP NY\yW25KRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFI2PjFpPkK1OlgzPTZzPD;hQi=>
A2780 MlHlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NFfxZpI1QCCq NEDNd|lKSzVyIE2gNE4xODZizszN MlnqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEK1OlEoRjJ3NkiyOVYyRC:jPh?=
HepG2 M2faWGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NVvhSnlJPDhiaB?= M37aOWlEPTBiPTCwMlAxQSEQvF2= NUXMdG53RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PFI2PjFpPkK1OlgzPTZzPD;hQi=>
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HCT8 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXraSZI2PDhiaB?= MXXJR|UxKD1iMD6wOlYh|ryP Mn[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OEK1OlEoRjJ3NkiyOVYyRC:jPh?=
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EC109 NX3SelVWS3m2b4TvfIlkcXS7IHHzd4F6 NHvGfIxKSzVyIE2gNE4yPCEQvF2= MnPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NkC2O|QoRjJ3N{[wOlc1RC:jPh?=
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A549 NFnMeJBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M1TXemdKPTBiPTCwMlAxPzFizszN NUjsVmZORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O|A4QDJpPkK1O|cxPzh{PD;hQi=>
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SMMC7721 M4fq[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NIO5bnc1QCCq M3zKSWlEPTBiPTCwMlAxQCEQvF2= Mo[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUi1NlgoRjJ3N{m4OVI5RC:jPh?=
HL60 MnrCR5l1d3SxeHnjbZR6KGG|c3H5 MVO0PEBp MVfJR|UxKD1iMD6wNFgh|ryP MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7OEWyPEc,OjV5OUi1Nlg9N2F-
A549 MlLDR5l1d3SxeHnjbZR6KGG|c3H5 NH7tbVg1QCCq NXfmO2RiUUN3MDC9JFAvODB6IN88US=> NHHpeY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe5PFUzQCd-MkW3PVg2Ojh:L3G+
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SW480 M3rHUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MoSzOFghcA>? MnnOTWM2OCB;IECuNFA5KM7:TR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd7OEWyPEc,OjV5OUi1Nlg9N2F-
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MOLT4 NYX0OllkS3m2b4TvfIlkcXS7IHHzd4F6 M1[3SFczKGh? NUTkVWp5UUN3MDC9JFAvODB{MjFOwG0> NHntT4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVA6Pid-MkW4NVkxQTZ:L3G+
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HeLa NVy3NmhUS3m2b4TvfIlkcXS7IHHzd4F6 NFnkNI84OiCq NW\FSld[UUN3MDC9JFAvODB|MjFOwG0> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzOUC5Okc,OjV6MUmwPVY9N2F-
DU145 M2jmcGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYTzco4{PzJiaB?= NEO1fJFKSzVyIE2gNE4xODN2IN88US=> NYTnflU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVkxQTZpPkK1PFE6ODl4PD;hQi=>
A549 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MoSzO|IhcA>? MoTGTWM2OCB;IECuNFA1PCEQvF2= MkHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUmwPVYoRjJ3OEG5NFk3RC:jPh?=
SGC7901 NXe0O45RS3m2b4TvfIlkcXS7IHHzd4F6 NV\IU2ZiPzJiaB?= M{fo[GlEPTBiPTCwMlAxPTFizszN MoTRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUmwPVYoRjJ3OEG5NFk3RC:jPh?=
K562 NV;P[mJOS3m2b4TvfIlkcXS7IHHzd4F6 MXW3NkBp MX3JR|UxKD1iMD6wNFUzKM7:TR?= NFLiR5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVA6Pid-MkW4NVkxQTZ:L3G+
MCF7 MlTNR5l1d3SxeHnjbZR6KGG|c3H5 MknKO|IhcA>? MX3JR|UxKD1iMD6wNFYzKM7:TR?= NEX3dYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUixPVA6Pid-MkW4NVkxQTZ:L3G+
NCI-H1975 MXTDfZRwfG:6aXPpeJkh[XO|YYm= MUC3NkBp M2\lN2lEPTBiPTCwMlAxPzdizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPThzOUC5Okc,OjV6MUmwPVY9N2F-
MX1 Mli0R5l1d3SxeHnjbZR6KGG|c3H5 NEP0OG04OiCq MWHJR|UxKD1iMD6wNFU2QSEQvF2= NU\uTldPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVk{OzRpPkK1PFE6OzN2PD;hQi=>
ID8 M{n4V2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoWxO|IhcA>? MYnJR|UxKD1iMD6wNVM5KM7:TR?= MlXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6MUmzN|QoRjJ3OEG5N|M1RC:jPh?=
L1210 MlXJR5l1d3SxeHnjbZR6KGG|c3H5 NI\xUYc4OiCq MlX5TWM2OCB;IECuNFI4PiEQvF2= NUSy[oNbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4NVk{OzRpPkK1PFE6OzN2PD;hQi=>
WI38 M4mwSGN6fG:2b4jpZ4l1gSCjc4PhfS=> MmTRO|IhcA>? MW\JR|UxKD1iMD6wOVU4KM7:TR?= M4XXOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEG5N|M1Lz5{NUixPVM{PDxxYU6=
MDA-MB-231 NEO0O4VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= NXjCPYZNPDhiaB?= NFPVZ29IUTVyIE2gNE4xOSEQvF2= M3e4PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO|UzOjxxYU6=
A549 NUfofXZZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXjPfXFUPDhiaB?= NWP1RohVT0l3MDC9JFAvODFizszN NFrudoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUiyO|UzOid-MkW4Nlc2OjJ:L3G+
PANC1 M2LDSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MYm0PEBp NHXVdGFIUTVyIE2gNE4xOTJizszN M1XLZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK3OVIzLz5{NUiyO|UzOjxxYU6=
HeLa MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NH;4dIQ1QCCq MVrHTVUxKD1iMD6wNkDPxE1? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{N{WyNkc,OjV6Mke1NlI9N2F-
HEK293 M4m3[WN6fG:2b4jpZ4l1gSCjc4PhfS=> NVf2VVRFPzJiaB?= NXHyTIZlUUN3MDC9JFAvODRizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh2MkO2OEc,OjV6NEKzOlQ9N2F-
SW480 M2nmTGN6fG:2b4jpZ4l1gSCjc4PhfS=> NWS4NVBnPDhiaB?= NU[wVFJCUUN3MDC9JFAvODB6IN88US=> NWe5S3Q{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|EzPjFpPkK1PFcyOjZzPD;hQi=>
HL60 MYTDfZRwfG:6aXPpeJkh[XO|YYm= NVvRb|QxPDhiaB?= NX7G[pY1UUN3MDC9JFAvODB6IN88US=> NWrEc48xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|EzPjFpPkK1PFcyOjZzPD;hQi=>
MCF7 M4SzRmN6fG:2b4jpZ4l1gSCjc4PhfS=> MWq0PEBp M{fFPWlEPTBiPTCwMlAxQCEQvF2= Mk\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{GyOlEoRjJ3OEexNlYyRC:jPh?=
SMMC7721 M4LRdGN6fG:2b4jpZ4l1gSCjc4PhfS=> MVS0PEBp MWjJR|UxKD1iMD6wNFgh|ryP NEHDVWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3NVI3OSd-MkW4O|EzPjF:L3G+
A549 MnfFR5l1d3SxeHnjbZR6KGG|c3H5 MlnyOFghcA>? NIXEfXJKSzVyIE2gNE4xODhizszN NXfWRVRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O|EzPjFpPkK1PFcyOjZzPD;hQi=>
SCC114 MmHORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MnO4O|IhcA>? NF\sS2NKSzVyIE2gNE4xODB|IN88US=> NIfRNJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi3Nlk5PCd-MkW4O|I6QDR:L3G+
HeLa MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NWfsW4x3PDhiaB?= NU\mWFJrUUN3MDC9JFAvODBzOTFOwG0> M3PXUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEiyOVE6Lz5{NUi4NlUyQTxxYU6=
MDA-MB-435 NVz6fGFKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NXnRfmRCPDhiaB?= NH3tXoNKSzVyIE2gNE4xODN|IN88US=> M3;yOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEiyOVE6Lz5{NUi4NlUyQTxxYU6=
SKOV3 M1f0dmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NX\CT5ljPDhiaB?= M3[0VmlEPTBiPTCwMlAxPjNizszN NGXxPVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi4NlUyQSd-MkW4PFI2OTl:L3G+
SKOV3-MDR1-M6/6 NYjpNHBzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MXm0PEBp NX;FeHF2UUN3MDC9JFEvOTh5MjFOwG0> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh6MkWxPUc,OjV6OEK1NVk9N2F-
A549 M2nWc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 Mke5OFghcA>? M1HnRmlEPTBiPTCwMlAxOjNizszN NULxOWlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|czOzZpPkK1PVM4OjN4PD;hQi=>
taxol-resistant A549 M{LpU2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M334R|Q5KGh? NXvUeHZ5UUN3MDC9JFAvPTJizszN M2H3R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO3NlM3Lz5{NUmzO|I{PjxxYU6=
EL4 NYT6cFJ3S3m2b4TvfIlkcXS7IHHzd4F6 MXi0PEBp NIDldJpKSzVyIE2gNU44KM7:TR?= M3SyeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUWxNFU4Lz5{NUm1NVA2PzxxYU6=
HeLa Mn3nRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4rpTlQ5KGh? NFW2fnVKSzVyIE2gNE4{QCEQvF2= MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl3OUixN{c,OjV7NUm4NVM9N2F-
A549 MmWzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NWX4b3U5PDhiaB?= MmrWTWM2OCB;IEKuPFIh|ryP M{Dtc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUW5PFE{Lz5{NUm1PVgyOzxxYU6=
LCC-6 MkPlR5l1d3SxeHnjbZR6KGG|c3H5 M2T5R|Mh\GG7cx?= MUDJR|UxKD1iMD6wNFE3KM7:TR?= NXvicJczRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PFUyQTVpPkK1PVg2OTl3PD;hQi=>
MDA435/LCC6MDR NWDlenZmS3m2b4TvfIlkcXS7IHHzd4F6 MUGzJIRigXN? NEfnV|NKSzVyIE2gNE4yPDR4IN88US=> NVnXRWpORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PFUyQTVpPkK1PVg2OTl3PD;hQi=>
A2780 MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MW[yJIRigXN? MVTJR|UxKD1iMD6wNlgh|ryP NYrqNmt4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wOFI1PzBpPkK2NFQzPDdyPD;hQi=>
SMMC7721 NXLFSGxRS3m2b4TvfIlkcXS7IHHzd4F6 Mo\kOFghcA>? M3fJWGlEPTBiPTCwMlAxQCEQvF2= M2TH[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4ME[4PFAzLz5{NkC2PFgxOjxxYU6=
HL60 MUfDfZRwfG:6aXPpeJkh[XO|YYm= MV20PEBp NYS0XWdJUUN3MDC9JFAvODB6IN88US=> NX7VXHk3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wOlg5ODJpPkK2NFY5QDB{PD;hQi=>
MCF7 MVzDfZRwfG:6aXPpeJkh[XO|YYm= Mni5OFghcA>? MWPJR|UxKD1iMD6wNFgh|ryP NHPjU4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC2PFgxOid-Mk[wOlg5ODJ:L3G+
A549 MnGwR5l1d3SxeHnjbZR6KGG|c3H5 MkHzOFghcA>? M1TxPGlEPTBiPTCwMlAxQCEQvF2= NHPie|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC2PFgxOid-Mk[wOlg5ODJ:L3G+
SW480 M{XHVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXS0PEBp NYjqXIlbUUN3MDC9JFAvODB6IN88US=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB4OEiwNkc,OjZyNki4NFI9N2F-
BEAS2B MmDlR5l1d3SxeHnjbZR6KGG|c3H5 M1rhWlQ5KGh? MVPJR|UxKD1iMD61PEDPxE1? MlrUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyNki4NFIoRjJ4ME[4PFAzRC:jPh?=
NB4 MX7DfZRwfG:6aXPpeJkh[XO|YYm= MoDNOFghcA>? MnLUTWM2OCB;IECuNFAzOyEQvF2= NYrVOYM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
NCI-H1975 MVjDfZRwfG:6aXPpeJkh[XO|YYm= NH;m[VM4OiCq NIHwXXRKSzVyIE2gNE4xODJ3IN88US=> Mn7hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
OVCAR8 NWq2d|V6S3m2b4TvfIlkcXS7IHHzd4F6 NXvrNJZJPDhiaB?= M4mxTGlEPTBiPTCwMlAxOzdizszN MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF|MkC3OUc,OjZzM{KwO|U9N2F-
MESSA MXLDfZRwfG:6aXPpeJkh[XO|YYm= NIfWXJI4OiCq MkjSTWM2OCB;IECuNFA1KM7:TR?= NYfvUJF1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
MDA-MB-468 M1O3UWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVrkNZNpPzJiaB?= M1;y[GlEPTBiPTCwMlAxPSEQvF2= MnL0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
A549 MW\DfZRwfG:6aXPpeJkh[XO|YYm= NI\aSGo4OiCq NWOzPVkxUUN3MDC9JFAvODB5IN88US=> M{[xclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUOyNFc2Lz5{NkGzNlA4PTxxYU6=
MDA-MB-231 NIrjXphEgXSxdH;4bYNqfHliYYPzZZk> M2LoN|czKGh? MmHVTWM2OCB;IECuNFA4KM7:TR?= MmfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
MDA-MB-436 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NHn1WlM4OiCq NG[5OGlKSzVyIE2gNE4xODhizszN MkG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
MESSA/DX5 NH3ubndEgXSxdH;4bYNqfHliYYPzZZk> MYC3NkBp NIDJR3BKSzVyIE2gNU44PjRizszN NUOxV4JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
HepG2 NF\YbXBEgXSxdH;4bYNqfHliYYPzZZk> M1LFSlQ5KGh? NGDvZ3RKSzVyIE2gNk43KM7:TR?= NUn4R21PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
PC3 NXX4UphUS3m2b4TvfIlkcXS7IHHzd4F6 M{T0eFQ5KGh? NXrtUohrUUN3MDC9JFQvQSEQvF2= NU\BcVU1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xN|IxPzVpPkK2NVMzODd3PD;hQi=>
NCI-ADR-RES MlnKR5l1d3SxeHnjbZR6KGG|c3H5 M2nLPVQ5KGh? MkDnTWM2OCB;IE[g{txO Mn;aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzM{KwO|UoRjJ4MUOyNFc2RC:jPh?=
KB M4rOeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NXjoNY1lPzJiaB?= MVTJR|UxKD1iMD6wNFUyKM7:TR?= M2jCXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MU[wNFIxLz5{NkG2NFAzODxxYU6=
KB-7d NWXY[GhmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYj4WmtYPzJiaB?= Mlm1TWM2OCB;IECuNFA5PCEQvF2= NWrBRWQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xOlAxOjBpPkK2NVYxODJyPD;hQi=>
KB-S15 NEHG[FZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MnrqO|IhcA>? NFvaWW1KSzVyIE2gNE4yOzVizszN MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4MECyNEc,OjZzNkCwNlA9N2F-
DU145 M3;z[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NX73cmJtT0l3MDC9JFAvODB4IN88US=> MnfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NEKyOFIoRjJ4MkSyNlQzRC:jPh?=
KB MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MmXSS2k2OCB;IECuNFA3PCEQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ2MkK0Nkc,OjZ{NEKyOFI9N2F-
A549 Mni0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NX76bpc5T0l3MDC9JFAvODB5NjFOwG0> NHPyXXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK0NlI1Oid-Mk[yOFIzPDJ:L3G+
vincristine-resistant KBVIN MkDtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4HBe2dKPTBiPTCxMlIyKM7:TR?= NVrMfIdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yOFIzPDJpPkK2NlQzOjR{PD;hQi=>
K562 NWTBU5FbS3m2b4TvfIlkcXS7IHHzd4F6 MUfJR|UxKD1iMD65JO69VQ>? NFXUZ2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK4O|QxOSd-Mk[yPFc1ODF:L3G+
U937 NHvsVWFEgXSxdH;4bYNqfHliYYPzZZk> MXW3NkBp MUHJR|UxKD1iMj6xJO69VQ>? NF\YUmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxOlQ3Pyd-Mk[zNVY1Pjd:L3G+
A549 NWTpeJdtS3m2b4TvfIlkcXS7IHHzd4F6 NGjjc4U4OiCq MXPJR|UxKD1iMj6xJO69VQ>? Mln0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MU[0OlcoRjJ4M{G2OFY4RC:jPh?=
MCF7 M4TS[2N6fG:2b4jpZ4l1gSCjc4PhfS=> NY\MdFdiPzJiaB?= NWTY[FZoUUN3MDC9JFIvOyEQvF2= NFS1e4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxOlQ3Pyd-Mk[zNVY1Pjd:L3G+
MOLT4 NU\ae217S3m2b4TvfIlkcXS7IHHzd4F6 MXe3NkBp NIj5[ZBKSzVyIE2gNk44KM7:TR?= NXHT[o5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVY1PjdpPkK2N|E3PDZ5PD;hQi=>
NCI-H1975 M4jKO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MX63NkBp MmC0TWM2OCB;IEKuPEDPxE1? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzNkS2O{c,OjZ|MU[0Olc9N2F-
HeLa MmDrR5l1d3SxeHnjbZR6KGG|c3H5 MXW3NkBp MYLJR|UxKD1iMj65JO69VQ>? Mo\FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MU[0OlcoRjJ4M{G2OFY4RC:jPh?=
DU145 MWDDfZRwfG:6aXPpeJkh[XO|YYm= M4TFclczKGh? M123d2lEPTBiPTCzMlEh|ryP NE\sSG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkOxOlQ3Pyd-Mk[zNVY1Pjd:L3G+
K562 NIXs[FhEgXSxdH;4bYNqfHliYYPzZZk> M17LeVczKGh? MlP6TWM2OCB;IEOuPEDPxE1? Mnv1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MU[0OlcoRjJ4M{G2OFY4RC:jPh?=
HL60 NGr5OolEgXSxdH;4bYNqfHliYYPzZZk> Mn[4O|IhcA>? NITL[ppKSzVyIE2gN{45KM7:TR?= NXrYR2pJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVY1PjdpPkK2N|E3PDZ5PD;hQi=>
SGC7901 M1K2cWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGjaOWU4OiCq MXPJR|UxKD1iOT64JO69VQ>? Mom4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|MU[0OlcoRjJ4M{G2OFY4RC:jPh?=
MES-SA M17mO2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXzqNY14PDhiaB?= NV3mcopVT0l3MDC9JFAvODB5IN88US=> MkH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ|NkCwOFcoRjJ4M{[wNFQ4RC:jPh?=
Rhabdomyosarcoma M33rUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmrEPVYhcA>? MmrLTWM2OCB;IECuNFA5PCEQvF2= NFWwUXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO4OlgyQCd-Mk[zPFY5OTh:L3G+
HT-29 MW\DfZRwfG:6aXPpeJkh[XO|YYm= M1OwOlMh\GG7cx?= M4nkNmlEPTBiPTCwMlAxODhizszN M{Gy[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEKyNVMyLz5{NkSyNlE{OTxxYU6=
MDA-MB-231 M13i[WN6fG:2b4jpZ4l1gSCjc4PhfS=> NGTxeXo4OiCq MYLJR|UxKD1iMD6wNFEh|ryP NYH6dXNHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OFgxOzdpPkK2OFQ5ODN5PD;hQi=>
PC3 MVnDfZRwfG:6aXPpeJkh[XO|YYm= NILieoY4OiCq MU\JR|UxKD1iMD6wNFEh|ryP M4jP[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NES4NFM4Lz5{NkS0PFA{PzxxYU6=
HCT116 NVXxOGNJS3m2b4TvfIlkcXS7IHHzd4F6 MXK0PEBp M2DBO2lEPTBiPTCwMlAxOjhizszN MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR2OECzO{c,OjZ2NEiwN|c9N2F-
A549 Mnz0R5l1d3SxeHnjbZR6KGG|c3H5 NYPZVohUUUN3MDC9JFAvODB4MzFOwG0> M4j3UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NES4NFM4Lz5{NkS0PFA{PzxxYU6=
HepG2 MUXDfZRwfG:6aXPpeJkh[XO|YYm= MXS0PEBp NXfTd3dTUUN3MDC9JFEvOjF5IN88US=> NH;6Xow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkS0PFA{Pyd-Mk[0OFgxOzd:L3G+
H460 Ml71R5l1d3SxeHnjbZR6KGG|c3H5 NUP6cpJTPDhiaB?= M4LnWWlEPTBiPTC0MlI5PyEQvF2= M{\oOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NES4NFM4Lz5{NkS0PFA{PzxxYU6=
cells after 48 hrs by SRB assay M3TS[2N6fG:2b4jpZ4l1gSCjc4PhfS=> MoLjS2k2OCB;IECuNFAyPDhizszN NYLwe2N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OlIxPTJpPkK2OFYzODV{PD;hQi=>
HeLa Mn;0RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MYK3NkBp MVXJR|UxKD1iMj6yPUDPxE1? NGj3VWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wNlgzPyd-Mk[2NFI5Ojd:L3G+
184B5 MnO5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MofoO|IhcA>? NEjyVJpKSzVyIE2gNk4{OiEQvF2= NEXpd3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[wNlgzPyd-Mk[2NFI5Ojd:L3G+
MDA-MB-231 M4HFemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MmjyO|IhcA>? NV7m[m94UUN3MDC9JFIvPTZizszN MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZyMkiyO{c,OjZ4MEK4Nlc9N2F-
MDA-MB-468 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MVy3NkBp Mn3hTWM2OCB;IEOuPFch|ryP M1rhW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkCyPFI4Lz5{Nk[wNlgzPzxxYU6=
MCF7 NYLI[JFWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVu3NkBp NULmZ|h2UUN3MDC9JFMvQTlizszN M4THUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkCyPFI4Lz5{Nk[wNlgzPzxxYU6=
Jurkat NHPpWFREgXSxdH;4bYNqfHliYYPzZZk> M3:yVFQ5KGh? NHrW[W5KSzVyIE2gNE4xODB3IN88US=> M3v4flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkO4NFQyLz5{Nk[zPFA1OTxxYU6=
U937 MkHrR5l1d3SxeHnjbZR6KGG|c3H5 MnjQOFghcA>? M3T3ZmlEPTBiPTCwMlAxPiEQvF2= M{fHR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkO4NFQyLz5{Nk[zPFA1OTxxYU6=
HeLa MkDqR5l1d3SxeHnjbZR6KGG|c3H5 NV7xbnJDPDhiaB?= MoHJTWM2OCB;IECuNFk6KM7:TR?= NYm5O4t7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|gxPDFpPkK2OlM5ODRzPD;hQi=>
cells assessed as cell growth inhibition after 48 hrs by MTT assay MlHER5l1d3SxeHnjbZR6KGG|c3H5 NGjFfGVKSzVyIE2gNE43PSEQvF2= NXjpTmo3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N|gxPDFpPkK2OlM5ODRzPD;hQi=>
MDA-MB-231 NH\OfnZEgXSxdH;4bYNqfHliYYPzZZk> MXi3NkBp MmLVTWM2OCB;IECuNFA{QSEQvF2= NEjSZ3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[5NFI4PCd-Mk[2PVAzPzR:L3G+
MCF7 M1n4dGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWC3NkBp NWPEWYNQUUN3MDC9JFAvODB5NDFOwG0> NYDyfWh1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2PVAzPzRpPkK2OlkxOjd2PD;hQi=>
U937 M1X6OGN6fG:2b4jpZ4l1gSCjc4PhfS=> M3PMV|czKGh? NX7KZ5FRUUN3MDC9JFAvODBzNk[g{txO NGrIcJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[5O|cyQCd-Mk[2PVc4OTh:L3G+
HL60 NULQZ|kzS3m2b4TvfIlkcXS7IHHzd4F6 M3P3U|czKGh? NXe1OFFnUUN3MDC9JFAvODBzOUmg{txO Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4OUe3NVgoRjJ4Nkm3O|E5RC:jPh?=
A549 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NHjHeZA4OiCq NIrudYZKSzVyIE2gNE4xODJzMjFOwG0> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ7N{exPEc,OjZ4OUe3NVg9N2F-
DU145 NVvHZZN5S3m2b4TvfIlkcXS7IHHzd4F6 NGX6TGs4OiCq NIC3UpNKSzVyIE2gNE4xODJ|IN88US=> NWLrSGExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2PVc4OThpPkK2Olk4PzF6PD;hQi=>
HeLa MVjDfZRwfG:6aXPpeJkh[XO|YYm= NIrqPIc4OiCq NIX0SXFKSzVyIE2gNE4xODNyMTFOwG0> NUe0OnRnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2PVc4OThpPkK2Olk4PzF6PD;hQi=>
HT-29 NXTZTJZDS3m2b4TvfIlkcXS7IHHzd4F6 Mnj2O|IhcA>? M3PQSGlEPTBiPTCwMlAxOzB2IN88US=> NHrpSXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[5O|cyQCd-Mk[2PVc4OTh:L3G+
K562 NFH1T3VEgXSxdH;4bYNqfHliYYPzZZk> MnnWO|IhcA>? NX;4NnhSUUN3MDC9JFAvODB5MUeg{txO MoHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4OUe3NVgoRjJ4Nkm3O|E5RC:jPh?=
MCF7 MkTIR5l1d3SxeHnjbZR6KGG|c3H5 MkTBO|IhcA>? MVfJR|UxKD1iMD6wNFc{OiEQvF2= NVnxO3ZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2PVc4OThpPkK2Olk4PzF6PD;hQi=>
NCI-H292 MoTaR5l1d3SxeHnjbZR6KGG|c3H5 M1;lWFczKGh? M3K2UmlEPTBiPTCwMlAxPiEQvF2= Mk\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5MUKwPVgoRjJ4N{GyNFk5RC:jPh?=
KB NHmzdZhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2flc|czKGh? NFGwOHBIUTVyIE2gNE4xODFizszN NGT3OJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke3PFYyOid-Mk[3O|g3OTJ:L3G+
DU145 NIrieYNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MWO0PEBp NIrpS|BKSzVyIE2gNE4xODN6IN88US=> M37IOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i1N|A3Lz5{Nke4OVMxPjxxYU6=
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MDA-MB-231 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NYPEfY03PDhiaB?= NFfYfIVIUTVyIE2gNE4xOSEQvF2= NXXvUoVXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5PVQ3QTBpPkK2PVk1PjlyPD;hQi=>
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A2780 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NV\RdlU{PDhiaB?= MUDJR|UxKD1iMD6wNFUh|ryP NGjaPVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G0PVY1OSd-MkexOFk3PDF:L3G+
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HCT116 MofkR5l1d3SxeHnjbZR6KGG|c3H5 M4DpPGlEPTBiPTCwMlAxODlizszN M{PaZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NESxPFkzLz5{N{S0NVg6OjxxYU6=
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HepG2 NFzBSoxEgXSxdH;4bYNqfHliYYPzZZk> Mke5TWM2OCB;IECuNFEzKM7:TR?= M2jaZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NESxPFkzLz5{N{S0NVg6OjxxYU6=
Capan2 NHLGeGpEgXSxdH;4bYNqfHliYYPzZZk> MlfaTWM2OCB;IECuNFE4KM7:TR?= MmTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEG4PVIoRjJ5NESxPFkzRC:jPh?=
A375 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NVPxXoJLUUN3MDC9JFAvODJ{IN88US=> NH:xdGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{S0NVg6Oid-Mke0OFE5QTJ:L3G+
A549 M4Hm[WN6fG:2b4jpZ4l1gSCjc4PhfS=> MnX5TWM2OCB;IECuNFI{KM7:TR?= NXnIPJBqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFE5QTJpPkK3OFQyQDl{PD;hQi=>
A2780 MkCxR5l1d3SxeHnjbZR6KGG|c3H5 MorBTWM2OCB;IECuNFM5KM7:TR?= NYLubmFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFE5QTJpPkK3OFQyQDl{PD;hQi=>
NCI-H1650 M{S4bWN6fG:2b4jpZ4l1gSCjc4PhfS=> M{Tn[GlEPTBiPTCwMlA3QCEQvF2= NYWxco93RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke0OFE5QTJpPkK3OFQyQDl{PD;hQi=>
NCI60 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NEPR[Go1QCCq MkT2S2k2OCB;IECuNFMyPSEQvF2= MlW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd2NEi5NlQoRjJ5NES4PVI1RC:jPh?=
HepG2 MnzQR5l1d3SxeHnjbZR6KGG|c3H5 NUnNOmIyPDhiaB?= MlXoTWM2OCB;IECuNFA3KM7:TR?= NXXLR3lERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NlcyOzBpPkK3OlI4OTNyPD;hQi=>
Hep3B M17P[mN6fG:2b4jpZ4l1gSCjc4PhfS=> NVrkW5FxPDhiaB?= MULJR|UxKD1iMD6wNkDPxE1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ{N{GzNEc,Ojd4MkexN|A9N2F-
A549 NIDhfXdEgXSxdH;4bYNqfHliYYPzZZk> MXe0PEBp NEHUcW5KSzVyIE2gNE4xOyEQvF2= NF;ScVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[yO|E{OCd-Mke2NlcyOzB:L3G+
MCF7 M3q2XmN6fG:2b4jpZ4l1gSCjc4PhfS=> MYK0PEBp NEnmem5KSzVyIE2gNE4xPiEQvF2= NWLBe|d7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2NlcyOzBpPkK3OlI4OTNyPD;hQi=>
A549 MXfDfZRwfG:6aXPpeJkh[XO|YYm= MXm0PEBp MorJTWM2OCB;IECuNFA5KM7:TR?= NYj6VFdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NFQ5ODdpPkK3O|A1QDB5PD;hQi=>
SW480 MlzQR5l1d3SxeHnjbZR6KGG|c3H5 NFP5V5A1QCCq NFrwOoJKSzVyIE2gNE4xODhizszN MlraQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MES4NFcoRjJ5N{C0PFA4RC:jPh?=
HL60 MXXDfZRwfG:6aXPpeJkh[XO|YYm= MmLBOFghcA>? M4Psd2lEPTBiPTCwMlAxQCEQvF2= Mn\GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5MES4NFcoRjJ5N{C0PFA4RC:jPh?=
SMMC7721 MlPTR5l1d3SxeHnjbZR6KGG|c3H5 NGfFXos1QCCq MWTJR|UxKD1iMD6wNFgh|ryP MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdyNEiwO{c,Ojd5MES4NFc9N2F-
MCF7 NX3vVFhjS3m2b4TvfIlkcXS7IHHzd4F6 MUC0PEBp NX7Y[21xUUN3MDC9JFAvODB6IN88US=> NVjXNIlpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3NFQ5ODdpPkK3O|A1QDB5PD;hQi=>
HeLa NH3MWHdEgXSxdH;4bYNqfHliYYPzZZk> MYW0PEBp NEDFcpRKSzVyIE2gNE4xODhizszN MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdyNEiwO{c,Ojd5MES4NFc9N2F-
A549 M3nnd2N6fG:2b4jpZ4l1gSCjc4PhfS=> M1vBXVQ5KGh? NUThUlNHUUN3MDC9JFAvODJizszN MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzdyNEiyNkc,Ojd5MES4NlI9N2F-
MCF7 M4S4O2N6fG:2b4jpZ4l1gSCjc4PhfS=> Mlf3OFghcA>? MVrJR|UxKD1iMD6xJO69VQ>? NFfkVYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{ewOFgzOid-Mke3NFQ5OjJ:L3G+
HeLa MoTER5l1d3SxeHnjbZR6KGG|c3H5 NXL2e3J2PzJiaB?= M1z2PGlEPTBiPTCxMlch|ryP NWPpUos6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OFg2QTVpPkK3O|Q5PTl3PD;hQi=>
K562 M2W5U2N6fG:2b4jpZ4l1gSCjc4PhfS=> MWi3NkBp NV7JUnBUUUN3MDC9JFIvPyEQvF2= M{L0V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{S4OVk2Lz5{N{e0PFU6PTxxYU6=
HCT116 NH;UU2hEgXSxdH;4bYNqfHliYYPzZZk> MnLDO|IhcA>? MVHJR|UxKD1iMz6zJO69VQ>? NGO3bJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e0PFU6PSd-Mke3OFg2QTV:L3G+
A549 M3m1SmN6fG:2b4jpZ4l1gSCjc4PhfS=> NW\IZ4oyPzJiaB?= Ml\LTWM2OCB;IEWuOUDPxE1? MnTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NEi1PVUoRjJ5N{S4OVk2RC:jPh?=
HepG2 MXjDfZRwfG:6aXPpeJkh[XO|YYm= Ml\UO|IhcA>? MmXETWM2OCB;IE[uO{DPxE1? NV3acnQ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OFg2QTVpPkK3O|Q5PTl3PD;hQi=>
HELF MkLnR5l1d3SxeHnjbZR6KGG|c3H5 NVGxXlVVOjRiaB?= M3\TZWlEPTBiPTC3MlE1KM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzd4OUCzNUc,Ojd5NkmwN|E9N2F-
BGC823 MVvDfZRwfG:6aXPpeJkh[XO|YYm= MoHCNlQhcA>? NYrLVpo4UUN3MDC9JFkvOjZizszN MkXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NkmwN|EoRjJ5N{[5NFMyRC:jPh?=
KB M13yc2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFr2fZM1QCCq MoTSTWM2OCB;IECuNFAxQCEQvF2= MoXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5OUexPVIoRjJ5N{m3NVkzRC:jPh?=
A549 MWnDfZRwfG:6aXPpeJkh[XO|YYm= Mn;1OFghcA>? NXL0OnlFUUN3MDC9JFAvODByOUmg{txO M37sUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{m3NVkzLz5{N{e5O|E6OjxxYU6=
MDA-MB-231 NHvjSpJEgXSxdH;4bYNqfHliYYPzZZk> NGLJfWo1QCCq MWPJR|UxKD1iMD6wNFMxPSEQvF2= MnjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5OUexPVIoRjJ5N{m3NVkzRC:jPh?=
MCF7 M2XhbWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmLDOFghcA>? NHG1W2pKSzVyIE2gNE4xOjJ5NTFOwG0> NGT6cFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e5O|E6Oid-Mke3PVcyQTJ:L3G+
KBVIN MlvkR5l1d3SxeHnjbZR6KGG|c3H5 NH:0SoQ1QCCq NUnMbXVwUUN3MDC9JFEvQDl4IN88US=> NYeyeXdwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3PVcyQTJpPkK3O|k4OTl{PD;hQi=>
HCT116 NIHSWWlEgXSxdH;4bYNqfHliYYPzZZk> MUW0PEBp M1PpRmlEPTBiPTCwMlEh|ryP M1zke|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEi3PFQ{Lz5{N{i4O|g1OzxxYU6=
Bel7402 NWK2e2VGS3m2b4TvfIlkcXS7IHHzd4F6 M3fiXVQ5KGh? NUjONJJxUUN3MDC9JFAvOSEQvF2= NVXDS2VLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PFc5PDNpPkK3PFg4QDR|PD;hQi=>
OVCAR8 M2rnPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MonJPVYhcA>? NEL3TJJKSzVyIE2gOUDPxE1? M4j1RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OEm0OVg6Lz5{N{i5OFU5QTxxYU6=
HeLa M{f4dmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3XqSVk3KGh? M{OzVmlEPTBiPTC1MlMh|ryP NV;JfXc4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke4PVQ2QDlpPkK3PFk1PTh7PD;hQi=>
HeLa M3nEVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHrSUVA1QCCq NH7qNZdIUTVyIE2gNE4xOzh7IN88US=> NXH4[4pMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlQ5QDNpPkK3PVY1QDh|PD;hQi=>
MiaPaCa NV7NeWh3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGHEcZI1QCCq M2rjbmdKPTBiPTCwMlA3KM7:TR?= NWXrd2tIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlQ5QDNpPkK3PVY1QDh|PD;hQi=>
IMR32 NXzjdnZWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fDVVQ5KGh? NWHJcJpqT0l3MDC9JFAvODh4IN88US=> NH7ScIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2OFg5Oyd-Mke5OlQ5QDN:L3G+
MDA-MB-231 MmLUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrUOFghcA>? NGPpNmlIUTVyIE2gNE4xQTJizszN MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4NEi4N{c,Ojd7NkS4PFM9N2F-
DU145 NVfjVlhXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= NYPsU|lrPDhiaB?= M2LRWmlEPTBiPTCwMlAyOSEQvF2= MmDJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7N{m1PVMoRjJ5OUe5OVk{RC:jPh?=
HeLa MkDvRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M1z0XFQ5KGh? MmjnTWM2OCB;IECuNFM3KM7:TR?= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl5OUW5N{c,Ojd7N{m1PVM9N2F-
MCF7 M3XiS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 MVK0PEBp NUWxS5Y4UUN3MDC9JFAvPjNizszN NVzQb2xRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5O|k2QTNpPkK3PVc6PTl|PD;hQi=>
ECA109 Mny4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? M4H6bFQ5KGh? NU[2THhPUUN3MDC9JFAvQTRizszN MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl5OUW5N{c,Ojd7N{m1PVM9N2F-
MDA-MB-435 M2rsTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NEXOV3E4OiCq M3PIbGlEPTBiPTCwMlAxODJizszN NF3PO4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m4N|g1Oid-Mke5PFM5PDJ:L3G+
HT-29 NFvwWIREgXSxdH;4bYNqfHliYYPzZZk> MXy3NkBp MXHJR|UxKD1iMD6wNFA5KM7:TR?= M{OwdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUizPFQzLz5{N{m4N|g1OjxxYU6=
MDA-MB-231 NWCzZYdES3m2b4TvfIlkcXS7IHHzd4F6 M3u5NVczKGh? NEjhVI1KSzVyIE2gNE4xODJ5IN88US=> NGfaR4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m4N|g1Oid-Mke5PFM5PDJ:L3G+
OVCAR3 M1zZXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NEL5WWI4OiCq Mn\zTWM2OCB;IECuNFA{OyEQvF2= MnvjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OEO4OFIoRjJ5OUizPFQzRC:jPh?=
H1299 MknaR5l1d3SxeHnjbZR6KGG|c3H5 NHL3XYozPCCq NH\Ie4xKSzVyIE2gNU42KM7:TR?= NXjvTnlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PFM5PDJpPkK3PVg{QDR{PD;hQi=>
HEK-Blue MVHGeY5kfGmxbjDhd5NigQ>? MoDVN{Bp NHjGSnFKSzVyIE2gO{46PDN{ODFOwG0> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB5NUW4NUc,OjhyN{W1PFE9N2F-
A549 NYDqcmt{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= MVi3NkBp MnrWTWM2OCB;IECuNFA3OiEQvF2= NEjMdlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5PVAxOyd-MkiwPVkxODN:L3G+
KB NGG2coNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= Ml:5O|IhcA>? NV;E[mtoUUN3MDC9JFAvODB4Mkeg{txO MkX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUmwNFMoRjJ6MEm5NFA{RC:jPh?=
MDA-MB-231 M3LnW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHT5U5Y4OiCq Ml3YTWM2OCB;IECuNFA5QDJizszN NGHBO5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5PVAxOyd-MkiwPVkxODN:L3G+
MCF7 MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NIXVSoE4OiCq NIm3d4NKSzVyIE2gNE4xOTB2IN88US=> M3zMOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEm5NFA{Lz5{OEC5PVAxOzxxYU6=
KBVIN NFi5No9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= MX:3NkBp MXnJR|UxKD1iMT65NlYh|ryP NYi3PHhXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwPVkxODNpPkK4NFk6ODB|PD;hQi=>
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MIAPaCa2 MYjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NXPnXXk1PDhiaB?= MWHJR|UxKD1iMj61JO69VQ>? NV;hdnc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2Olc5PzJpPkK4OlY4QDd{PD;hQi=>
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A2780 NXXHToRES3m2b4TvfIlkcXS7IHHzd4F6 NV7sZWdZPDhiaB?= MXTJR|UxKD1iMD6xOlQzKM7:TR?= Mnf5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MUmyNFQoRjJ6N{G5NlA1RC:jPh?=
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BGC823 MlL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWS5OkBp M{DIW2lEPTBiPTCwMlAxODZizszN NVjlcXB5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N|c{QTZpPkK4O|M4Ozl4PD;hQi=>
HepG2 MnHiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXG5OkBp NInpW5RKSzVyIE2gNE4xODd4IN88US=> MmfwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5M{ezPVYoRjJ6N{O3N|k3RC:jPh?=
A2780 M1\IVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn7HPVYhcA>? NHz3d5dKSzVyIE2gNE4xOjB2IN88US=> MlHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5M{ezPVYoRjJ6N{O3N|k3RC:jPh?=
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HCT116 MkDqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? Ml;WO|IhcA>? MVvJR|UxKD1iMD6wNFQyKM7:TR?= NUHNNWFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4OVc2PThpPkK4PFU4PTV6PD;hQi=>
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MV411 MUjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? MWW3NkBp M1K2N2lEPTBiPTCwMlAyPyEQvF2= MlmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MUKxPVgoRjNyMkGyNVk5RC:jPh?=
HGC27 NE\nfHVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M37VN|czKGh? NIHw[nVKSzVyIE2gNE4xOjhizszN NXzQdYlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVIyQThpPkOwNlEzOTl6PD;hQi=>
HeLa MnSzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NVLvfmRSPzJiaB?= MVzJR|UxKD1iMD6wOFYh|ryP MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJzMkG5PEc,OzB{MUKxPVg9N2F-
A549 M2\mVGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 NHvXOpU4OiCq MVzJR|UxKD1iMD6wOVEh|ryP NWXlbGhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNVIyQThpPkOwNlEzOTl6PD;hQi=>
HeLa M{TzNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7 M{ey[lQ5KGh? M4PoNmlEPTBiPTCwMlAxOjhizszN MoLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{OUexNVgoRjNyMkm3NVE5RC:jPh?=
SKOV3 NVf4SoxySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|YYm= M1\o[FQ5KGh? M33BOGlEPTBiPTCwMlAxPSEQvF2= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ7N{GxPEc,OzB{OUexNVg9N2F-
SKOV3-MDR1-M6/6 MkfBRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? MlW1OFghcA>? NYDqR|J[UUN3MDC9JFEvOiEQvF2= M3LYV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkm3NVE5Lz5|MEK5O|EyQDxxYU6=
HCC1806 MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NVm5UGs4OjRiaB?= MYnJR|UxKD1iMD6wNFEh|ryP MmDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|OUK5OVMoRjNyM{myPVU{RC:jPh?=
BEAS2B NFTtO5NCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?= M{i2elI1KGh? NIHC[pRKSzVyIE2gNE4xODdizszN MnzrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|OUK5OVMoRjNyM{myPVU{RC:jPh?=
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HepG2 MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>? NFjaclQzPCCq Mo\zTWM2OCB;IECuNFA6KM7:TR?= MmH6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB|OUK5OVMoRjNyM{myPVU{RC:jPh?=
PANC1 MkDkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl? NEHQV4UzPCCq NYPzNlBVUUN3MDC9JFAvODRizszN NVTpUY1mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzPVI6PTNpPkOwN|kzQTV|PD;hQi=>
MDA-MB-231 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NHTMbZE1QCCq M1r2VWlEPTBiPTCwMlAxPCEQvF2= M3r0VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNEOzO|g{Lz5|MESzN|c5OzxxYU6=
A549 NH\SVIVEgXSxdH;4bYNqfHliYYPzZZk> MWq0PEBp MojrTWM2OCB;IECuNFA1KM7:TR?= Mn30QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB2M{O3PFMoRjNyNEOzO|g{RC:jPh?=
PANC1 NWi5RZBkS3m2b4TvfIlkcXS7IHHzd4F6 M3rO[lQ5KGh? Ml7TTWM2OCB;IECuNFYh|ryP MlHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB2M{O3PFMoRjNyNEOzO|g{RC:jPh?=
4T1 MnG0R5l1d3SxeHnjbZR6KGG|c3H5 MV20PEBp MkjuTWM2OCB;IECuNFk1KM7:TR?= NFL5RmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MESzN|c5Oyd-M{C0N|M4QDN:L3G+
A375 NUHjd3g{S3m2b4TvfIlkcXS7IHHzd4F6 NWi5N|FzPDhiaB?= NF\iXnVKSzVyIE2gNE4yKM7:TR?= NInkN5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MESzN|c5Oyd-M{C0N|M4QDN:L3G+
LLC NWDuephES3m2b4TvfIlkcXS7IHHzd4F6 M1exUVQ5KGh? NWPxe2l[UUN3MDC9JFAvOTh7IN88US=> MoPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB2M{O3PFMoRjNyNEOzO|g{RC:jPh?=
B16F10 MlnHR5l1d3SxeHnjbZR6KGG|c3H5 NXrTOpROPDhiaB?= NIXkOndKSzVyIE2gNE42OyEQvF2= Ml;iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB2M{O3PFMoRjNyNEOzO|g{RC:jPh?=
B16F10 spheroid NXn2Z45[S3m2b4TvfIlkcXS7IHHzd4F6 NFLZfpE1QCCq M33DXmlEPTBiPTC4MlAyKM7:TR?= NGHhOG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MESzN|c5Oyd-M{C0N|M4QDN:L3G+
Assay
Methods Test Index PMID
Western blot p-ERK / ERK ; MARCKS (pSer159/163) ; Src (pTyr416) ; p-JAK2 / p-STAT3 / p-AKT / p-MAPK / Bcl-xl / MCL-1 ; Id1 ; MARCKS 20068074 26015406 29849942 25344919
Growth inhibition assay Cell viability 28823711
Immunofluorescence α-tubulin ; Rab11a/BV9 22904633 29290815
In vivo

The inhibition rations of Paclitaxel alone on BC-V and BC-ER tumors are 49.78% and 51.23%, respectively. Treatment of six cycles of 20 mg/kg Paclitaxel significantly reduces the percentages of Ki-67-positive cells to 20.4% in BC-V tumors and 25.1% in BC-ER tumors, respectively. [4]

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs
  • Concentrations: 0.1-100 pM
  • Incubation Time: 72 hours
  • Method:

    Cells including human neonatal dermal microvascular ECs (HMVECs), human umbilical vein ECs (HUVECs), human umbilical artery ECs (HUAVECs), normal human astrocytes (NHAs), normal human dermal fibroblasts (NHDFs), normal human epidermal keratinocytes (NHEKs), human mammary epithelial cells (HMEpCs), human prostate epithelial cells (PrEpCs) and human umbilical artery smooth muscle cells (UASMCs) are cultured. Cell proliferations are performed in 96-well plates using cells between passages 6 and 12. Cells are seeded at 3000–5000 cells/well and allowed to attach for 4 hours. Paclitaxel, diluted in culture medium, is added in quadruplicate wells and the cells ae incubated for 3 days before MTS reagents are added to quantitate the live cells in each well.

  • (Only for Reference)
Animal Research:

[4]

  • Animal Models: Female, 20-22 g homozygous nude athymic mice with BC-V and BC-ER tumors
  • Dosages: 20 mg/kg
  • Administration: Administered via i.v.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 171 mg/mL
(200.25 mM)
Water Insoluble
Ethanol ''18 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5% DMSO+40% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 853.91
Formula

C47H51NO14

CAS No. 33069-62-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05183126 Not yet recruiting Drug: Paclitaxel Breast Cancer University of Michigan Rogel Cancer Center June 2022 Phase 4
NCT04252768 Not yet recruiting Drug: Eftilagimod Alpha|Drug: Paclitaxel Metastatic Breast Cancer Immutep S.A.S. June 2022 Phase 1
NCT04675450 Not yet recruiting Drug: Placebo|Drug: NBP Softgel Capsules Breast Cancer|Peripheral Neuropathy Conjupro Biotherapeutics Inc.|CSPC-NBP Pharmaceutical Co. Ltd. June 30 2022 Phase 2
NCT05185947 Not yet recruiting Drug: Paclitaxel|Drug: Nilotinib Peritoneal Carcinomatosis|Peritoneal Neoplasms|Ovarian Cancer|Ovarian Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Appendiceal Cancer|Appendiceal Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 18 2022 Phase 2
NCT05159050 Not yet recruiting Drug: Paclitaxel-loaded tumor penetrating microparticles Peritoneal Carcinomatosis Carlos Chan|Institute of Quantitative Systems Pharmacology (IQSP)|University of Iowa January 2022 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I am interested in the product S1150 for in vivo studies, could you please give some suggestions for the formulation?

Answer:
S1150 in 1% DMSO+30% polyethylene glycol+1% Tween 80 at 30mg/ml is a suspension. If the you want to inject it, there is another vehicle, 5% DMSO+5% Tween 80+ddH2O. S1150 can dissolve in it at 2.5mg/ml as a clear solution. It is a common formulation we used, but is not cited from reference.

Question 2:
the compound was dissolved into 1ml DMSO and diluted with 1x PBS or water (500ul + 9.5 ml PBS or water). I found the white precipitation goes out. How to figure it out?

Answer:
Paclitaxel has very low solubility in water based solution and that's why it precipitated out once you dilute the stock with water. The vehicle we suggest is: 1% DMSO+30% polyethylene glycol+1% Tween 80.

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