Home Autophagy Autophagy inhibitor Lucanthone

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Lucanthone Autophagy inhibitor

Cat.No.S6471

Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.
Lucanthone Autophagy inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 340.48

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S647101 Ethanol]68 mg/mL]false]DMSO]33 mg/mL]false]Water]Insoluble]false Purity: 99.87%
99.87

Chemical Information, Storage & Stability

Molecular Weight 340.48 Formula

C20H24N2OS

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 479-50-5 -- Storage of Stock Solutions

Synonyms N/A Smiles CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O

Solubility

In vitro
Batch:

Ethanol : 68 mg/mL

DMSO : 33 mg/mL (96.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02014545 Withdrawn
Brain Metastases|Non-small Cell Lung Cancer
Wake Forest University Health Sciences|Spectrum Pharmaceuticals Inc
 January 2016 Phase 2

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