DMOG

Catalog No.S7483 Synonyms: Dimethyloxalylglycine

DMOG Chemical Structure

Molecular Weight(MW): 175.14

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 97 In stock
USD 194 In stock
USD 327 In stock
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1 Customer Review

  • Western blot analysis of the indicated proteins after the treatment with DMOG (K).

    Theranostics, 2017, 7(13): 3293-3305. DMOG purchased from Selleck.

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Biological Activity

Description DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.
Targets
HIF prolyl hydroxylase [1]
()
In vitro

DMOG shows only weakly active in the microsomal system, but efficiently suppresses hydroxyproline synthesis in intact cells. [1] DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human SR cell NVfs[oZrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHnuU4tKdmirYnn0bY9vKG:oIHj1cYFvKFOUIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61O|k1PiEQvF2= MnuyV2FPT0WU
human LB996-RCC cell M3niTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH[yd5BKdmirYnn0bY9vKG:oIHj1cYFvKEyEOUm2MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTVwNki3O{DPxE1? MkPwV2FPT0WU
human LOUCY cell M4HmRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGxQXUO\IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuN|Q6OyEQvF2= NEjPSItUSU6JRWK=
human KS-1 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XjcWlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlI2PTdizszN MoKxV2FPT0WU
human U-698-M cell MmXsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoHLTY5pcWKrdHnvckBw\iCqdX3hckBWNTZ7OD3NJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvOzNyNjFOwG0> MlH2V2FPT0WU
human A3-KAW cell Mn\iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2O2SGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvQDF5NDFOwG0> MWLTRW5ITVJ?
human BL-70 cell NW\2S49CT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTdyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuPVQzOyEQvF2= NIHxZ5RUSU6JRWK=
human DMS-273 cell NVjnbohxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{P4UGlvcGmkaYTpc44hd2ZiaIXtZY4hTE2VLUK3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2Njl4NTFOwG0> NYXvPFl2W0GQR1XS
human CAL-39 cell NFnae3hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvBeW9QUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yQS5|Mke3JO69VQ>? Mn;rV2FPT0WU
human KYSE-410 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIe1OXZKdmirYnn0bY9vKG:oIHj1cYFvKEu\U1WtOFExKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjBwOEG5O{DPxE1? MWfTRW5ITVJ?
human YT cell MkjjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfET4oxUW6qaXLpeIlwdiCxZjDoeY1idiC\VDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKzMlM6QDRizszN NW[2VIg3W0GQR1XS
human LC-2-ad cell MmfBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXLJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yOE42PTd|IN88US=> Mln0V2FPT0WU
human COR-L105 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlX3TY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEGwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI3NjR2M{[g{txO MljaV2FPT0WU
human CAL-12T cell M4rCcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nxfmlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUGyWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI3NjV3MEKg{txO MWDTRW5ITVJ?
human KU812 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkCxTY5pcWKrdHnvckBw\iCqdX3hckBMXThzMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlQ2PzlizszN NYW1ZlhkW0GQR1XS
human OPM-2 cell MkOyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH:xcHdKdmirYnn0bY9vKG:oIHj1cYFvKE:STT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvQDJ{NzFOwG0> M3T2S3NCVkeHUh?=
human SW982 cell Moj1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXrJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{OuO|AxPyEQvF2= NHPwSVNUSU6JRWK=
human HH cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV\ld|B5UW6qaXLpeIlwdiCxZjDoeY1idiCKSDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO0MlAzOzVizszN NI\vcIFUSU6JRWK=
human RS4-11 cell NVnYS5RZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV;RfIxlUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{PC5zOEC2JO69VQ>? MnKyV2FPT0WU
human BEN cell M{\5TWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\4VWlvcGmkaYTpc44hd2ZiaIXtZY4hSkWQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{[uPFE5PyEQvF2= M3XGWnNCVkeHUh?=
human CCRF-CEM cell NUXaXVJ[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3Hoe2lvcGmkaYTpc44hd2ZiaIXtZY4hS0OURj3DSW0h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Py55N{K5JO69VQ>? NUnQdGlmW0GQR1XS
human EW-13 cell M4HVTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;M{muNFQ5OSEQvF2= NXvsTJVvW0GQR1XS
human NCI-H2228 cell NVrReHB3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1:2fGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyNlI5KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PDJwOEG4JO69VQ>? NELEPJVUSU6JRWK=
human KE-37 cell MoDRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGtGNTN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NEOuNlkyPSEQvF2= MWDTRW5ITVJ?
human A4-Fuk cell NUjKcVJ5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mnm5TY5pcWKrdHnvckBw\iCqdX3hckBCPC2IdXugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OU4xOzZ2IN88US=> M3[zWXNCVkeHUh?=
human MZ1-PC cell NUfjbmJRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvLTY5pcWKrdHnvckBw\iCqdX3hckBOYjFvUFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OU46QDh6IN88US=> NYrMcpBZW0GQR1XS
human MLMA cell NH[3fYNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4jUd2lvcGmkaYTpc44hd2ZiaIXtZY4hVUyPQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS2MlMzQTJizszN NX;3SoFGW0GQR1XS
human EB-3 cell NV7oZ4tpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXj5SYt4UW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OFkvPTd7MjFOwG0> NXu3PJRQW0GQR1XS
human 293T cells  NVT4d20xTnWwY4Tpc44h[XO|YYm= NFrqSnIzNjVibV2= MYnJcohq[mm2aX;uJI9nKEqPSlSyMY1m\GmjdHXkJGg{UzN4IHTlcYV1cHmuYYTpc44hcW5iaIXtZY4hOjl|VDDj[YxteyCjdDCyMlUhdU1? NW\VVppWOTl|NUmxOlc>

... Click to View More Cell Line Experimental Data

In vivo DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. [2] Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. [4]

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: VSMC cells
  • Concentrations: ~100 μM
  • Incubation Time: 72-96 hours
  • Method:

    To analyze DNA synthesis as an index of cellular proliferation, VSMC are plated in 48-well plates (5,000 per square centimeter) in growth medium, incubated overnight, and serum-deprived (1% FCS) for 24 h. Replicate wells are then stored at −70°C for baseline (day 0) cell counts, and fresh medium with or without growth factors is added to the remaining wells, which are incubated 72-96 h in 20 or 5% O2. Days 0 and 3 or 4 cell counts are determined by lysing cells in a buffer containing a fluorescent dye, which has minimal fluorescence by itself but fluoresces when bound to DNA or RNA. Absolute cell numbers are calculated by comparing the fluorescence of specimens with that of a standard curve similarly prepared using a known number of cells.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Mice (C57Bl6)
  • Formulation: 8 mg/mouse
  • Dosages: 8 mg in 0.5 ml saline
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 35 mg/mL (199.84 mM)
Water 35 mg/mL (199.84 mM)
Ethanol 35 mg/mL (199.84 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 175.14
Formula

C6H9NO5

CAS No. 89464-63-1
Storage powder
in solvent
Synonyms Dimethyloxalylglycine

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID