Catalog No.S2505 Synonyms: BRL 49653
Molecular Weight(MW): 473.5
Rosiglitazone, a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ with IC50 of 42 nM.
Cited by 6 Publications
3 Customer Reviews
Total and phosphorylated Akt were detected by western blot in protein lysates of liver, inguinal WAT and gastrocnemius muscle from mice that were treated with an insulin bolus after an overnight fast.
Mol Metab 2013 2(3), 215-26. Rosiglitazone maleate purchased from Selleck.
Effect of rosiglitazone (RSG) treatment on neutrophil shift toward an N2 phenotype.Representative photomicrographs showing Ym1 (green) and neutrophils (red) double immunostaining 24 (upper) and 48 hours (lower) after permanent middle cerebral artery occlusion (pMCAO) in vehicle (VEH)- or RSG-treated mice.
Stroke 2013 44(12), 3498-508. Rosiglitazone maleate purchased from Selleck.
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|Description||Rosiglitazone, a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ with IC50 of 42 nM.|
Rosiglitazone is an insulin-sensitising agent of the thiazolidinedione class of oral antihyperglycaemic drugs. Rosiglitazone exhibits insulin-sensitising activity 60- to 200-fold higher than that of troglitazone, englitazone, or piogliazone in rodent models of insulin ressitance. Rosiglitazone reduces hyperglycaemia by improving insulin sensitivity in adipose tissue, the liver and skeletal muscle tissue. Such insulin sensitisation may be partly attributable to the effects of Rosiglitazone on the expression of molecules involved in the insulin signalling cascade. In adipose tissue, Rosiglitazone-mediated PPARγ stimulation promotes adipocyte differentiation. Rosiglitazone may also promote the uptake of free fatty acids in adipose tissue, thus reducing systemic free fatty acid levels. The insulin sensitivity of the liver and peripheral tissues may be modulated indirectly by Rosiglitazone-mediated changes in levels of fatty acid or adipocyte-derived factors, such as adiponectin and TNFα. Rosiglitazone may also be involved in modulating the expression of adiponectin receptors in some tissues, which may be relevant to some aspects of insulin sensitisation. 
|In vitro||DMSO||94 mg/mL (198.52 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02737709||Terminated||Drug: Paclitaxel and Carboplatin regimen||Non-small Cell Lung Cancer||Sun Yat-sen University||March 2016||Phase 2|
|NCT01402076||Completed||Drug: Tasimelteon|Drug: Rosiglitazone|Drug: Midazolam||Healthy Volunteers||Vanda Pharmaceuticals||August 2011||Phase 1|
|NCT01100619||Completed||Drug: rosiglitazone|Drug: XL184||Papillary Thyroid Cancer|Follicular Thyroid Cancer|Huerthle Cell Thyroid Cancer|Renal Cell Carcinoma||Exelixis||April 2010||Phase 1|
|NCT01415128||Completed||Drug: Omeprazole|Drug: Rosiglitazone|Drug: Desipramine||Erectile Dysfunction||VIVUS Inc.||April 2010||Phase 1|
|NCT01376063||Completed||Drug: FG-4592||Healthy Adult Subjects||FibroGen||March 2010||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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