Imatinib (STI571)

Name: Imatinib (STI571)
Brand: Selleck Chemicals
SKU: S2475
Rating: 5 (222 reviews)

For research use only.

Catalog No.S2475 Synonyms: Gleevec, Glivec, CGP057148B

222 publications

CAS No. 152459-95-5

Imatinib (STI571, CGP057148B, Gleevec) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.

Selleck's Imatinib (STI571) has been cited by 222 publications

Science, 2020, 370(6513)eabc2754

PubMed: 33004676 ( click the link to review the publication )

Cancer Cell, 2019, 36(4):431-443

PubMed: 31543464 ( click the link to review the publication )

Cancer Cell, 2018, 34(2):271-285.e7

PubMed: 30107177 ( click the link to review the publication )

Cancer Cell, 2018, 34(4):626-642

PubMed: 30300583 ( click the link to review the publication )

Cancer Cell, 2014, 26(6):840-50

PubMed: 25490448 ( click the link to review the publication )

Cell Stem Cell, 2012, 10(2):210-7

PubMed: 22305570 ( click the link to review the publication )

Cell Host Microbe, 2021, 29(6):941-958.e10

PubMed: 33989515 ( click the link to review the publication )

Nat Commun, 2021, 12(1):51

PubMed: 33397955 ( click the link to review the publication )

Cell Death Dis, 2021, 12(4):367

PubMed: 33824300 ( click the link to review the publication )

Cell Death Dis, 2021, 12(5):456

PubMed: 33963175 ( click the link to review the publication )

Cell Death Discov, 2021, 7(1):139

PubMed: 34117218 ( click the link to review the publication )

J Clin Endocrinol Metab, 2021, dgab020

PubMed: 33524147 ( click the link to review the publication )

Cell Chem Biol, 2021, S2451-9456(21)00303-2

PubMed: 34216546 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab011

PubMed: 33438013 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab014

PubMed: 33450762 ( click the link to review the publication )

Biochem Pharmacol, 2021, 190:114658

PubMed: 34146540 ( click the link to review the publication )

Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

PubMed: 33403501 ( click the link to review the publication )

Ann Hematol, 2021, 10.1007/s00277-020-04357-z

PubMed: 34110462 ( click the link to review the publication )

Nat Metab, 2021, 3(5):682-700

PubMed: 34031592 ( click the link to review the publication )

Blood, 2020, 8 pii: blood

PubMed: 32270193 ( click the link to review the publication )

Cell Host Microbe, 2020, 11;27(3):476-485 e7

PubMed: 32101706 ( click the link to review the publication )

Nat Commun, 2020, 11(1):5060

PubMed: 33033246 ( click the link to review the publication )

Sci Adv, 2020, 6(33):eaaz8850

PubMed: 32851160 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2020, 117(8):4300-4309

PubMed: 32047031 ( click the link to review the publication )
Clin Cancer Res, 2020, 21;clincanres31422019

PubMed: 32439698 ( click the link to review the publication )

Genome Med, 2020, 18;12(1):17

PubMed: 32070411 ( click the link to review the publication )

Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

Cell Rep, 2020, 33(1):108221

PubMed: 33027668 ( click the link to review the publication )

Cell Rep, 2020, 24;30(12):3951-3963 e4

PubMed: 32209458 ( click the link to review the publication )

J Hematol Oncol, 2020, 13(1):80

PubMed: 32552902 ( click the link to review the publication )

Antioxid Redox Signal, 2020, 32(1):35-59

PubMed: 31656084 ( click the link to review the publication )

Cancer Lett, 2020, 469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cancers (Basel), 2020, 25;12(5)

PubMed: 32344828 ( click the link to review the publication )

Cancers (Basel), 2020, 13;12(2) pii: E436

PubMed: 32069833 ( click the link to review the publication )

PLoS Pathog, 2020, 16(8):e1008823

PubMed: 32845931 ( click the link to review the publication )

Br J Cancer, 2020, 10.1038/s41416-020-0952-1

PubMed: 32572172 ( click the link to review the publication )

FASEB J, 2020, 34(3):3773-3791

PubMed: 31945226 ( click the link to review the publication )

Mol Cell Proteomics, 2020, 10.1074/mcp.RA119.001504

PubMed: 32102969 ( click the link to review the publication )

Aging (Albany NY), 2020, 12(17):17662-17680

PubMed: 32927433 ( click the link to review the publication )

Front Bioeng Biotechnol, 2020, 20;8:482

PubMed: 32509756 ( click the link to review the publication )

Am J Cancer Res, 2020, 10(12):4251-4265

PubMed: 33414998 ( click the link to review the publication )

Front Oncol, 2020, 12;10:696

PubMed: 32528877 ( click the link to review the publication )

J Cell Sci, 2020, 11 pii: jcs

PubMed: 32393599 ( click the link to review the publication )

Sci Rep, 2020, 10(1):11269

PubMed: 32647179 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Am J Physiol Cell Physiol, 2020, 10.1152/ajpcell.00290.2020

PubMed: 32966125 ( click the link to review the publication )

Front Physiol, 2020, 11:555006

PubMed: 33329018 ( click the link to review the publication )

Oncol Rep, 2020, 44(5):2152-2164

PubMed: 32901871 ( click the link to review the publication )
J Pharm Biomed Anal, 2020, 195:113864

PubMed: 33387839 ( click the link to review the publication )

J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

PubMed: 33165739 ( click the link to review the publication )

Micromachines (Basel), 2020, 11(2)

PubMed: 32085455 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Biochim Biophys Acta Gen Subj, 2020, 1864(4):129507

PubMed: 31881245 ( click the link to review the publication )

Commun Biol, 2020, 3(1):18

PubMed: 31925328 ( click the link to review the publication )

bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )

Front Aging Neurosci, 2020, 12:7

PubMed: 32116646 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 529(3):699-706

PubMed: 32736695 ( click the link to review the publication )

Ann N Y Acad Sci, 2020, 1467(1):77-93

PubMed: 31930541 ( click the link to review the publication )

J Pers Med, 2020, 10(4)E234

PubMed: 33212994 ( click the link to review the publication )

Cancer Cell, 2020, 38(6):872-890.e6

PubMed: 33217342 ( click the link to review the publication )

Hemasphere, 2020, 4(6):e497

PubMed: 33196013 ( click the link to review the publication )

Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

PubMed: 33144287 ( click the link to review the publication )

J Clin Invest, 2019, 129(3):1167-1179

PubMed: 30629551 ( click the link to review the publication )

Nat Commun, 2019, 10(1):2204

PubMed: 31101827 ( click the link to review the publication )

Sci Adv, 2019, 5(2):eaau7130

PubMed: 30775435 ( click the link to review the publication )

Dev Cell, 2019, 51(2):236-254

PubMed: 31543445 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2019.215939

PubMed: 31289206 ( click the link to review the publication )

Cell Rep, 2019, 28(9):2331-2344

PubMed: 31461650 ( click the link to review the publication )

J Control Release, 2019, 310:141-154

PubMed: 31430499 ( click the link to review the publication )

Thyroid, 2019, 29(5):674-682

PubMed: 30784360 ( click the link to review the publication )

J Exp Clin Cancer Res, 2019, 18;38(1):85

PubMed: 30777101 ( click the link to review the publication )
Cancer Discov, 2019, 9(6):756-777

PubMed: 30862724 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(6):1137-1148

PubMed: 30926633 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(11):1985-1996

PubMed: 31308077 ( click the link to review the publication )

Hum Reprod, 2019, 34(3):506-518

PubMed: 30597012 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(12):8314-8327

PubMed: 31576676 ( click the link to review the publication )

Neuropharmacology, 2019, 149:13-26

PubMed: 30731136 ( click the link to review the publication )

Cancer Manag Res, 2019, 11:5197-5208

PubMed: 31239774 ( click the link to review the publication )

Eur J Hum Genet, 2019, 27(4):574-581

PubMed: 30573803 ( click the link to review the publication )

Prostate, 2019, 79(3):259-264

PubMed: 30370673 ( click the link to review the publication )

Molecules, 2019, 24(3)

PubMed: 30754629 ( click the link to review the publication )

Molecules, 2019, 25(1)

PubMed: 31877920 ( click the link to review the publication )

Med Oncol, 2019, 36(3):30

PubMed: 30796703 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 512(4):871-876

PubMed: 30929921 ( click the link to review the publication )

Leuk Lymphoma, 2019, 60(1):189-199

PubMed: 29741440 ( click the link to review the publication )

Leuk Res, 2019, 78:12-20

PubMed: 30660961 ( click the link to review the publication )

Mol Med Rep, 2019, 20(4):3233-3239

PubMed: 31432109 ( click the link to review the publication )

Anticancer Res, 2019, 39(7):3785-3793

PubMed: 31262905 ( click the link to review the publication )

Res Vet Sci, 2019, 124:1-9

PubMed: 30716585 ( click the link to review the publication )

J Exp Med, 2019, 216(3):688-703

PubMed: 30710055 ( click the link to review the publication )

Cancer Invest, 2019, 37(6):242-252

PubMed: 31296070 ( click the link to review the publication )

Nat Biomed Eng, 2018, 2(8):578-588

PubMed: 31015631 ( click the link to review the publication )

Acta Neuropathol, 2018, 135(5):779-798

PubMed: 29305721 ( click the link to review the publication )

Nat Commun, 2018, 9(1):2377

PubMed: 29915352 ( click the link to review the publication )

Nat Commun, 2018, 9(1):4583

PubMed: 30389923 ( click the link to review the publication )
Elife, 2018, 7e36656

PubMed: 29901437 ( click the link to review the publication )

Int J Cancer, 2018, 142(1):156-164

PubMed: 28906000 ( click the link to review the publication )

Oncogene, 2018, 37(21):2837-2849

PubMed: 29511345 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 25;37(1):170

PubMed: 30045750 ( click the link to review the publication )

Cell Death Discov, 2018, 4:48

PubMed: 29707241 ( click the link to review the publication )

Front Immunol, 2018,

PubMed: 30127787 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(12):2551-2563

PubMed: 30217967 ( click the link to review the publication )

Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

Neoplasia, 2018, 20(8):857-870

PubMed: 30025229 ( click the link to review the publication )

Cancer Sci, 2018, 109(9):2792-2800

PubMed: 29957833 ( click the link to review the publication )

Mol Cancer Res, 2018, 16(6):935-946

PubMed: 29545477 ( click the link to review the publication )

J Cell Physiol, 2018, 233(9):7467-7479

PubMed: 29663362 ( click the link to review the publication )

Cancer Sci, 2018, 109(11):3591-3601

PubMed: 30142229 ( click the link to review the publication )

Biochem Pharmacol, 2018, 156:248-264

PubMed: 30142322 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2018, 315(6):L965-L976

PubMed: 30211651 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2018, 58(2):181-193

PubMed: 28915060 ( click the link to review the publication )

Biomed Pharmacother, 2018, 106:403-410

PubMed: 29966986 ( click the link to review the publication )

Int J Oncol, 2018, 52(6):2061-2068

PubMed: 29620253 ( click the link to review the publication )

Molecules, 2018, 23(10)

PubMed: 30326595 ( click the link to review the publication )

Oncol Rep, 2018, 40(2):902-908

PubMed: 29845257 ( click the link to review the publication )

PLoS One, 2018, 13(2):e0191890

PubMed: 29389967 ( click the link to review the publication )

BMC Pharmacol Toxicol, 2018, 19(1):80

PubMed: 30514402 ( click the link to review the publication )

Int J Clin Exp Pathol, 2018, 11(1):179-188

PubMed: 31938099 ( click the link to review the publication )

Hemasphere, 2018, 2(3):e41

PubMed: 31723769 ( click the link to review the publication )
Oncotarget, 2018, 9(100):37352-37366

PubMed: 30647837 ( click the link to review the publication )

Sci Rep, 2018, 8(1):14896

PubMed: 30291293 ( click the link to review the publication )

Nat Commun, 2017, 8(1):1420

PubMed: 29127277 ( click the link to review the publication )

Leukemia, 2017, 31(11):2376-2387

PubMed: 28366933 ( click the link to review the publication )

Cancer Res, 2017, 77(20):5554-5563

PubMed: 28923853 ( click the link to review the publication )

Cancer Res, 2017, 77(5):1142-1154

PubMed: 27899378 ( click the link to review the publication )

Cell Rep, 2017,

PubMed: 28564604 ( click the link to review the publication )

Cell Rep, 2017, 20(12):2775-2783

PubMed: 28930674 ( click the link to review the publication )

Elife, 2017, 6

PubMed: 28199182 ( click the link to review the publication )

Oncogene, 2017, 36(15):2066-2073

PubMed: 27694901 ( click the link to review the publication )

Cell Death Dis, 2017, 8(10):e3117

PubMed: 29022905 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Cell Chem Biol, 2017, 24(7):858-869

PubMed: 28669525 ( click the link to review the publication )

Cell Chem Biol, 2017, 24(10):1250-1258.e4

PubMed: 28919041 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(9):1729-1738

PubMed: 28619758 ( click the link to review the publication )

Mol Pharm, 2017, 14(10):3558-3567

PubMed: 28829147 ( click the link to review the publication )

Sci Rep, 2017,

PubMed: 28638122 ( click the link to review the publication )

J Biol Chem, 2017, 292(9):3683-3691

PubMed: 28087699 ( click the link to review the publication )

J Biol Chem, 2017,

PubMed: 27903634 ( click the link to review the publication )

Invest New Drugs, 2017, 35(4):427-435

PubMed: 28349229 ( click the link to review the publication )

BMC Cancer, 2017,

PubMed: 28806950 ( click the link to review the publication )

Bioconjug Chem, 2017, 28(10):2608-2619

PubMed: 28903003 ( click the link to review the publication )

Molecules, 2017, 22(12)

PubMed: 29206199 ( click the link to review the publication )

Drug Des Devel Ther, 2017, 11:1115-1126

PubMed: 28435223 ( click the link to review the publication )
Dig Dis Sci, 2017, 62(5):1193-1203

PubMed: 28315973 ( click the link to review the publication )

PLoS One, 2017, 12(7):e0180401

PubMed: 28753604 ( click the link to review the publication )

PLoS One, 2017, 12(5):e0177871

PubMed: 28520795 ( click the link to review the publication )

Leuk Lymphoma, 2017, 58(6):1455-1467

PubMed: 27733071 ( click the link to review the publication )

SLAS Discov, 2017, 22(7):915-922

PubMed: 28346107 ( click the link to review the publication )

Zhonghua Xue Ye Xue Za Zhi, 2017, 38(12):1036-1042

PubMed: 29365396 ( click the link to review the publication )

Oncotarget, 2017, 8(14):23213-23227

PubMed: 28390196 ( click the link to review the publication )

Oncotarget, 2017, 8(27):43662-43677

PubMed: 28599273 ( click the link to review the publication )

Blood Adv, 2017, 1(20):1635-1644

PubMed: 29296810 ( click the link to review the publication )

Leuk Lymphoma, 2017, 58(8):1903-1913

PubMed: 27931141 ( click the link to review the publication )

Oncotarget, 2017, 8(17):28906-28921

PubMed: 28423649 ( click the link to review the publication )

Oncotarget, 2017, 8(23):37594-37604

PubMed: 28410239 ( click the link to review the publication )

Blood, 2016, 28;127(17):2131-43

PubMed: 26864341 ( click the link to review the publication )

J Clin Invest, 2016, 126(10):3961-3980

PubMed: 27643437 ( click the link to review the publication )

EMBO Mol Med, 2016, 1;8(2):105-16

PubMed: 26758680 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2302-2313

PubMed: 27474148 ( click the link to review the publication )

Traffic, 2016, 17(4):351-68

PubMed: 26650385 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2016, 311(2):L364-74

PubMed: 27261451 ( click the link to review the publication )

Cell Signal, 2016, 28(10):1489-501

PubMed: 27373199 ( click the link to review the publication )

Transl Oncol, 2016, 9(6):540-547

PubMed: 27835791 ( click the link to review the publication )

Oncol Rep, 2016, 36(6):3643-3650

PubMed: 27748929 ( click the link to review the publication )

Pharmacol Rep, 2016, 68(1):1-6

PubMed: 26721343 ( click the link to review the publication )

Ups J Med Sci, 2016, 121(2):140-5

PubMed: 26953716 ( click the link to review the publication )

Cell Biochem Biophys, 2016, 74(2):277-83

PubMed: 26912059 ( click the link to review the publication )
Oncotarget, 2016, 7(29):45916-45925

PubMed: 27322141 ( click the link to review the publication )

Oncotarget, 2016, 7(34):54583-54595

PubMed: 27409346 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26709-23

PubMed: 27050374 ( click the link to review the publication )

Genes Cancer, 2016, 7(9-10):292-300

PubMed: 28050230 ( click the link to review the publication )

Nat Commun, 2015, 6:7002

PubMed: 25926053 ( click the link to review the publication )

Nat Commun, 2015, 6:8481

PubMed: 26412466 ( click the link to review the publication )

Oncogene, 2015, 10.1038/onc.2015.111

PubMed: 25893286 ( click the link to review the publication )

J Med Chem, 2015, 58(23):9228-37

PubMed: 26562217 ( click the link to review the publication )

J Urol, 2015, 194(6):1797-805

PubMed: 26055827 ( click the link to review the publication )

Cancer Sci, 2015, 106(2):160-70

PubMed: 25458015 ( click the link to review the publication )

J Cell Sci, 2015, 128(2):251-65

PubMed: ( click the link to review the publication )

Exp Cell Res, 2015, 332(1):1-10

PubMed: 25637219 ( click the link to review the publication )

Leuk Lymphoma, 2015, 56(6):1813-20

PubMed: 25146433 ( click the link to review the publication )

Leuk Res, 2015, 39(3):355-60

PubMed: 25575688 ( click the link to review the publication )

Leuk Res, 2015, 10.1016/j.leukres.2015.08.007

PubMed: 26346348 ( click the link to review the publication )

Oncol Lett, 2015, 10(5):2835-2841

PubMed: 26722250 ( click the link to review the publication )

Sci Rep, 2015, 5:9775

PubMed: 25965812 ( click the link to review the publication )

Blood, 2014, 123(21):3296-304

PubMed: 24723681 ( click the link to review the publication )

Leukemia, 2014, 28(4):977-9

PubMed: 24186003 ( click the link to review the publication )

Elife, 2014, 3:e02523

PubMed: 24844246 ( click the link to review the publication )

Sci Signal, 2014, 7(322):ra38

PubMed: 24757178 ( click the link to review the publication )

Stem Cells, 2014, 32(9):2324-37

PubMed: 24806995 ( click the link to review the publication )

Mol Cancer Ther, 2014, 13(6):1664-72

PubMed: 24723451 ( click the link to review the publication )

Mol Oncol, 2014, 8(5):968-81

PubMed: 24747080 ( click the link to review the publication )
Drug Metab Dispos, 2014, 42(3):318-22

PubMed: 24335466 ( click the link to review the publication )

J Alzheimers Dis, 2014, 41(3):729-37

PubMed: 24662099 ( click the link to review the publication )

Thrombo Res, 2014, 135(1):155-60

PubMed: 25527332 ( click the link to review the publication )

PLoS One, 2014, 9(1):e84900

PubMed: 24454763 ( click the link to review the publication )

PLoS One, 2014, 9(3):e91782

PubMed: 24626299 ( click the link to review the publication )

Biochem Biophys Res Commun, 2014, 455(3-4):256-61

PubMed: 25449280 ( click the link to review the publication )

Leuk Lymphoma, 2014, 22:1-8

PubMed: 25146433 ( click the link to review the publication )

Biochem Biophy Res Co, 2014, 10.1016/j.bbrc.2014.11.002

PubMed: ( click the link to review the publication )

BMC Vet Res, 2014, 10:105

PubMed: 24885200 ( click the link to review the publication )

Mol Med Rep, 2014, 10(3):1519-24

PubMed: 24939418 ( click the link to review the publication )

Biol Pharm Bull, 2014, 37(8):1330-5

PubMed: 25087954 ( click the link to review the publication )

Harbin Medical University, 2014, Wang GY

PubMed: ( click the link to review the publication )

Oncoscience, 2014, 1(1):57-68

PubMed: 25593988 ( click the link to review the publication )

Oncotarget, 2014, 5(7):1926-41

PubMed: 24732172 ( click the link to review the publication )

Clin Cancer Res, 2013, 19(24):6935-42

PubMed: 24132921 ( click the link to review the publication )

PLoS Biol, 2013, 11(3):e1001515

PubMed: 23526884 ( click the link to review the publication )

Clin Cancer Res, 2013, 19(9):2381-92

PubMed: 23532890 ( click the link to review the publication )

Cancer Discov, 2013, 3(5):520-33

PubMed: 23365119 ( click the link to review the publication )

Apoptosis, 2013, 18(11):1437-1446

PubMed: 23851982 ( click the link to review the publication )

Apoptosis, 2013, 18(9):1060-70

PubMed: 23613107 ( click the link to review the publication )

Transl Oncol, 2013, 6(2):187-96

PubMed: 23544171 ( click the link to review the publication )

Int J Mol Med, 2013, 31(2):453-8

PubMed: 23233089 ( click the link to review the publication )

Leuk Lymphoma, 2013, 54(2):342-52

PubMed: 22762548 ( click the link to review the publication )

Biomed Chromatogr, 2013, 27(4):502-8

PubMed: 23034891 ( click the link to review the publication )
J Virol, 2012, 86(18):10112-22

PubMed: 22787216 ( click the link to review the publication )

Leuk Res, 2012, 37(2):183-9

PubMed: 23218026 ( click the link to review the publication )

Clin Pharmacol Ther, 2011, 90(1):157-63

PubMed: 21633340 ( click the link to review the publication )

Cell Death Dis, 2011, 2:e170

PubMed: 21654828 ( click the link to review the publication )

FASEB J, 2011, 25(10):3661-73

PubMed: 21705667 ( click the link to review the publication )

PLoS One, 2010, 5(11):e14143

PubMed: 21152443 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description

Targets

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. ^[1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. ^[2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. ^[3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
LAMA-84	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MX3JR\|UxRTBwMEezNFQh\|ryP	M1X4NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EM-2	MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MmLFTWM2OD1yLkC4PFgh\|ryP	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MEG-01	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1;mdGlEPTB;MD6wPFkzOSEQvF2=	NXnTdGxqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
BV-173	M3rSfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MXPJR\|UxRTBwMUi3OEDPxE1?	NXTvVWxORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
K-562	MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MX\JR\|UxRTBwMkK0N\|Ih\|ryP	NFTPWWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
CGTH-W-1	NULhNVRxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVHJR\|UxRTBwM{izO\|Qh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ST486	NXr4RnVbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MV7JR\|UxRTBwNki1OEDPxE1?	NVH0XosxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NCI-H1436	NHSxWotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MX\JR\|UxRTBwOUe4NFEh\|ryP	NFXidXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NOS-1	MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NYHTT21nUUN3ME2xMlY2Ozh\|IN88US=>	NVj1ZpdiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
A498	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MoPDTWM2OD1{LkW3NlI{KM7:TR?=	M3;aelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
BE-13	MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NVzNdYtWUUN3ME2yMlYzOTB4IN88US=>	M1XkTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SUP-T1	Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NXHOeoFXUUN3ME2zMlgzQTB5IN88US=>	M3\2dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NCI-H1770	M362Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MlOyTWM2OD13LkW3NlYzKM7:TR?=	NUXjZnJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
IMR-5	NHW3d4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Mn3ZTWM2OD14LkKyNVQ4KM7:TR?=	NHvUc4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB2241-RCC	NXe0XXNnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M17kbWlEPTB;OD6wO\|M5PCEQvF2=	NVXmeXlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
TGBC24TKB	NFr3dGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M1Tsd2lEPTB;OD6zOFA2OiEQvF2=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SCC-15	NVrIU4tFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MXfJR\|UxRTFyLke3PFgh\|ryP	Mom5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
BB49-HNC	NIT6SY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M1TQR2lEPTB;MUSuN\|M{PSEQvF2=	M4TsVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES7	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYTJR\|UxRTF2LkezO\|kh\|ryP	NXfVT5NLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LB2518-MEL	NXy5[otVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M{S0TGlEPTB;MU[uOlA6PCEQvF2=	NIS5ZWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NCI-H510A	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M2LHNGlEPTB;MUeuNlQ1OiEQvF2=	M4\6WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-441-T	M3S3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmLTTWM2OD1zNz6yPFg3KM7:TR?=	M{K3VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
HH	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MVHJR\|UxRTF5LkO5PVkh\|ryP	NETSNZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LC4-1	M4rjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3z3[GlEPTB;MUiuNFY2OiEQvF2=	NV3BNJpVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
KARPAS-45	NWfUeGFRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M4noXWlEPTB;MUiuNVg1QCEQvF2=	NHLSc2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB1047-RCC	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M{LjTWlEPTB;MUiuOFQ2OiEQvF2=	NH;pR4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NKM-1	MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGHUNJhKSzVyPUG5MlM2PTJizszN	NYXGU5pVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SCLC-21H	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M3S3TWlEPTB;MkCuNVI1PiEQvF2=	NW\PVY5URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
RS4-11	M3\LXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NFPWSmJKSzVyPUKwMlM{ODhizszN	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ALL-PO	MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M3GwVmlEPTB;MkCuPFE1QSEQvF2=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
GDM-1	NYqwSlU3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NXziO2NMUUN3ME2yNk42QTR3IN88US=>	M4nFU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
DMS-79	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NUe5NpY3UUN3ME2yOE41QTN2IN88US=>	M2X1S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
MPP-89	NFOzZmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NWLDcnlDUUN3ME2yOU43QDd2IN88US=>	NHPlfmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NB10	MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Mn7tTWM2OD1{Nj60Olk6KM7:TR?=	NV7D[lJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LS-513	NUXyW\|RST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MU\JR\|UxRTJ4Lki4OFch\|ryP	MlnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
L-540	MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXHJR\|UxRTJ4LkmxOFMh\|ryP	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ES1	MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M32xdGlEPTB;MkeuOVIyKM7:TR?=	NXjNbo1qRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NTERA-S-cl-D1	M{PBRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NFLVN4pKSzVyPUOwMlUxQTNizszN	NFrjZXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MY\JR\|UxRTN{Lkm0OVQh\|ryP	NVfGcY5DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
Calu-6	MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M2T3XWlEPTB;M{OuNVg2PSEQvF2=	NWDVXGhERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
CTV-1	NF\yXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MnH1TWM2OD1\|Mz65O\|g6KM7:TR?=	NF[ySIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
YT	NF30WG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MkPpTWM2OD1\|OD61NlA6KM7:TR?=	MkLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-6	NFO1NlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M37O[2lEPTB;NEGuNlc6QCEQvF2=	NHX4W2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
HT-144	Mn6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NGrDOZBKSzVyPUSxMlU1QDZizszN	M4jycVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-13	NHHxOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MVnJR\|UxRTR{LkK3PVEh\|ryP	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KALS-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NVezbY9YUUN3ME20N{4yOzJ7IN88US=>	NV35WYt{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
MOLT-16	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MXnJR\|UxRTR3LkC3OVIh\|ryP	M4fCRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
D-336MG	Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXLJR\|UxRTR3Lkm1PVkh\|ryP	M3mzflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-11	M4\iT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MVnJR\|UxRTR4Lk[1N{DPxE1?	M1TKXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EB2	M4nNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NUK3XVNkUUN3ME20Ok43QTlizszN	NI\2OHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SK-N-DZ	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NHLzfW1KSzVyPUS4MlA6PjFizszN	NFrTPXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SW684	M1[5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M2HjdmlEPTB;NEiuNlY6PSEQvF2=	NHXMfWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-18	NH;xPZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NXrDVYNTUUN3ME20PE41Ozl3IN88US=>	Ml:3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
RL95-2	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MV7JR\|UxRTVyLkC3NUDPxE1?	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
CHP-126	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MYTJR\|UxRTVyLki5NFUh\|ryP	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCI-H1395	NHzhb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NEXJbYlKSzVyPUWxMlc5OzVizszN	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
TE-15	NILQWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MUHJR\|UxRTV{LkK1OVYh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ES4	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NH;XXmNKSzVyPUWyMlk4PzVizszN	M37IeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1:xWmlEPTB;NUOuPVQ2PSEQvF2=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SIMA	MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M4ToU2lEPTB;NUeuN\|MyOSEQvF2=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
LB647-SCLC	NXrVfGRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MonVTWM2OD14ND6xNVg5KM7:TR?=	M3jpbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
KY821	M13FTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M3qwRWlEPTB;NkSuNlU2OiEQvF2=	MoXLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LC-2-ad	NFTvfIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NVjzR4gzUUN3ME22OU44PjBzIN88US=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KP-N-RT-BM-1	NFjZRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M{PJWmlEPTB;Nk[uOlM3PiEQvF2=	NV;ZbHpuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SW872	NV;qVYExT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3LKXGlEPTB;NkeuOFM5OiEQvF2=	NFPxb2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
ES5	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M1PnWGlEPTB;NkeuOlk3QCEQvF2=	M{PIWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SK-NEP-1	NFzVbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NF\kWJlKSzVyPU[4MlM5ODNizszN	MnvGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
RPMI-6666	NFnMbGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			Ml;RTWM2OD15MT6wN\|Ih\|ryP	M2ThTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
UACC-812	M4\C[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4PwNGlEPTB;N{GuNVYxQSEQvF2=	NU\FSHA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
COLO-829	M1fFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NWTFOpJ5UUN3ME23Nk43QTh5IN88US=>	M4LRdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
KP-N-YS	NYX6WIV7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MYPJR\|UxRTd{LkexN\|kh\|ryP	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
GI-1	M1XiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MWnJR\|UxRTd\|LkK4Olgh\|ryP	M1HaPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ETK-1	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NXLkZ2xuUUN3ME23N{41QTN{IN88US=>	Mnj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LXF-289	M3Pmb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NFHMe4ZKSzVyPUezMlczQSEQvF2=	M1HVSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CAS-1	MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MnnqTWM2OD15Mz64PFU4KM7:TR?=	NHfsTHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-22	Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NXTiZYJjUUN3ME23OE44OTF3IN88US=>	M4HMRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NCI-H2196	NVH2NVU5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NHzWeJpKSzVyPUe1MlY{PzlizszN	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EoL-1-cell	MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MXLJR\|UxRThzLk[5OlMh\|ryP	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-247MG	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MmLHTWM2OD16Mj6wNlQ5KM7:TR?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
Becker	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			NWG3b4ZtUUN3ME24Nk4{PDhzIN88US=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
IST-MEL1	M4nH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MYDJR\|UxRTh{LkO0PFIh\|ryP	NIjOVGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MDA-MB-134-VI	NVvpZVlkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVTJR\|UxRTh{LkW5PVYh\|ryP	NUDGR3FPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NCI-H1092	M{HMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NI\YOnRKSzVyPUi0MlAyQTdizszN	NFjaNHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
KINGS-1	NHqzRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NYXqcXBmUUN3ME24Ok4yPjF6IN88US=>	NWD1NIR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
HCC2218	MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M1rvOGlEPTB;OE[uO\|kyOyEQvF2=	NIL6epc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
GI-ME-N	M37LWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NX\rNIhLUUN3ME24O{44Pjl7IN88US=>	NGXXZnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
AM-38	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MUHJR\|UxRTh6LkO5OVMh\|ryP	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KNS-42	MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MX7JR\|UxRTh7LkGwNVgh\|ryP	M1LZRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
C8166	M4rIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MUHJR\|UxRTh7Lk[xNlUh\|ryP	M1rWW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
Ramos-2G6-4C10	NVjN[GxpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYfvVnFLUUN3ME24PU45PzF7IN88US=>	NFfK[G49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
CTB-1	MnvvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NHK0XIZKSzVyPUmwMlY{PTdizszN	Mlf0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
HCE-4	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MUfJR\|UxRTlzLkGzN\|Yh\|ryP	M2fk[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NCI-H526	MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWDJR\|UxRTl{LkSxNFMh\|ryP	NF\oR5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
ECC4	MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			Mn;ZTWM2OD17ND6yOVU2KM7:TR?=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCCIT	MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			M{W5XGlEPTB;OUWuN\|I6OiEQvF2=	M4XGTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
MZ7-mel	NXrmT4pST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYj5bVVnUUN3ME25OU46ODRizszN	NIPwPJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
COLO-684	MnS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MWLJR\|UxRTl4LkKzPFUh\|ryP	MnfjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
SU-DHL-1	M1vNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NIjKOnJKSzVyPUm2Mlk5PDJizszN	M{n6VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SF126	M1fvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			M4T0WGlEPTB;OUeuOVIyPyEQvF2=	M4flS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NMC-G1	MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NVrWXJBCUUN3ME25PE41PTV2IN88US=>	Mn\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NB14	NH;RTXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MlLXTWM2OD17OD65NlA5KM7:TR?=	MmOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
VA-ES-BJ	NVj1c3ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M1nSZmlEPTB;OUmuOFA2PiEQvF2=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
CHO	M4P2TmZ2dmO2aX;uJIF{e2G7			NX\QeHBvUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgVIxifGWuZYSt[IVzcX[nZDDndo94fGhiZnHjeI9zKHKnY3XweI9zKGKndHGgdIhwe3Cqb4L5cIF1cW:wIHnuJGNJVyClZXzsd{whUUN3ME2wMlI1\|ryPLh?=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjF4Nkm1NEc,OTJzNk[5OVA9N2F-
CHO	MVLGeY5kfGmxbjDhd5NigQ>?			NHzGXItKdmirYnn0bY9vKG:oIHPobY1memmlIGDES2YhemWlZYD0c5Ihf2m2aDDjMYtqfCCleYTvdIxie22rYzDkc41icW5icHjvd5Bpd3K7bHH0bY9vKGmwIFPIU{Bk\WyuczygTWM2OD1yLkK2{txONg>?	NFPSWIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkG2Olk2OCd-MUKxOlY6PTB:L3G+
CHO	MWPGeY5kfGmxbjDhd5NigQ>?			NVyw[oE{UW6qaXLpeIlwdiCxZjDjbIlu\XKrYzDQSGdHKHKnY3XweI9zKHerdHigR3NHNTGUIHP5eI9xdGG\|bXnjJIRwdWGrbjDwbI9{eGixconsZZRqd25iaX6gR2hQKGOnbHzzMEBKSzVyPUCuPVbPxE1w	MlvxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJzNk[5OVAoRjF{MU[2PVUxRC:jPh?=
K562	NIXHN2REgXSxdH;4bYNqfHliYYPzZZk>			M1\ifGN6fG:2b4jpZ{Bm\m[nY4SgbY4hUzV4MjDj[YxteyxiSVO1NF0xNjFzzszNMi=>	M2DJelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
K562	MWnGeY5kfGmxbjDhd5NigQ>?			M{m0e2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIdzd3e2aDD1d4lv\yCPVGSgZZN{[XluIFnDOVA:OC52zszNMi=>	MkPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3NUK3OlAoRjF2NUWyO\|YxRC:jPh?=
Sf9	M3jYNmZ2dmO2aX;uJIF{e2G7			MXTUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO\|aX7nJHNnQSClZXzsd{whUUN3ME2wMlXPxE1w	NVXCdJJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWxOVU5PDFpPkG1NVU2QDRzPD;hQi=>
Sf9	MoW1SpVv[3Srb36gZZN{[Xl?			MXrUVH9VWkGQU2DPVnRGWjpiZX\mcJV5KG:oIFjv[YNpe3R\|M{O0NkBqdiCEQ2LQMYV5eHKnc4PpcochW2Z7IHPlcIx{NCCLQ{WwQVAvQc7:TT6=	NV\aXVFWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWxOVU5PDFpPkG1NVU2QDRzPD;hQi=>
K562	MkX6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NIi1bWNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGs2PjJiY3XscJMtKEmFNUC9NE4yQDMQvF2u	NHnxV3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkOzNlQ1OCd-MU[zN\|I1PDB:L3G+
U937	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M{PJWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgWVk{PyClZXzsd{whUUN3ME2xOO69VS5?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjN\|MkS0NEc,OTZ\|M{K0OFA9N2F-
BA/F3	MofaRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFjyfJM1QCCqcoO=	NELvVIJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KEKlcj3hZowhdmWpYYTpeoUh[2WubIOg[ZhxemW\|c3nu[{BV\WxvUFTHSnJj\XSjIHvpcoF{\SCjc4Pld5Nm\CCjczDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xOjgQvF2u	NYCxRodFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ\|PD;hQi=>
BA/F3	Mm\2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?	NH\BdYg2KHSxIEGwJJVO	NXq0PGRCPDhiaILz	NWj3WZM1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKFSnbD3TTFIuU0RiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYYSgOUB1dyBzMDD1UUBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFU2\|ryPLh?=	M{HBZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BA/F3	NUH4VYhVSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	NH\BO402KHSxIEGwJJVO	Mlu0OFghcHK\|	MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegWIVtNVOKMz3TTFIuU0RiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYYSgOUB1dyBzMDD1UUBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNFg5\|ryPLh?=	NGW5OXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
32D	MVrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVvlb3RiPDhiaILz	NVvYVXZmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTCzNmQh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDwNlExKGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBie3Onc4Pl[EBieyCycn;sbYZmemG2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD6xNVLPxE1w	M3vWWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
32D	M4HlRWN6fG:2b4jpZ4l1gSCjc4PhfS=>			NHLnWGJEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTCzNmQh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDwNlExKEKlcj3hZowtKEmFNUC9NE4yQc7:TT6=	NWHEdVA{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ\|PD;hQi=>
BA/F3	NHPj[odCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NYHXeXVyPDhiaILz	MlP4RY51cXC{b3zp[oVz[XSrb36gZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2jYnygZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkG5{txONg>?	M1q1WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BA/F3	M1vEVWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NXzoPFhzPDhiaILz	M4LpSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOgeJJidnOoZXP0[YQhf2m2aDDwNlExKEKlcj3hZowh[XO\|ZYPz[YQh[XNicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuNVnPxE1w	NWDETWpnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ\|PD;hQi=>
M07e	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NHnGfoc1QCCqcoO=	Mom2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPMEflJGJkei2jYnygcoVo[XSrdnWgZ4VtdHNiZYjwdoV{e2mwZzDzeIVuKGOnbHyg[oFkfG:{IHHzd4V{e2WmIHHzJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjJ3N988UU4>	NVW0SnNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ\|PD;hQi=>
BA/F3	NGLvXJFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MVW0PEBpenN?	NIjxZ2VCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBCOzN5TjDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjN\|Od88UU4>	NFnFbFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
BA/F3	NU\KVIhjSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	MXm1JJRwKDFyIIXN	NFP1d4Q1QCCqcoO=	MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegUnBONWGkbDDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEA2KHSxIEGwJJVOKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4{QTQQvF2u	M1H1SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BA/F3	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M3:xSFQ5KGi{cx?=	NEnsOItCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBCOzN2bDDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjl4Mt88UU4>	MmjPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
32D	MUHDfZRwfG:6aXPpeJkh[XO\|YYm=			MnHXR5l1d3SxeHnjJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViM{LEJGJkei2jYnygcoVo[XSrdnWgZ4VtdHNuIFnDOVA:OjEQvF2u	M4H5[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BaF3	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M121d2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcZVzcW6nIFLhSlMh[2WubIOg[ZhxemW\|c3nu[{B4cWymIIT5dIUhVlCPL1HMT{BjgSCdM1jdeIh6dWmmaX7lJJVxfGGtZTDhd5NigSxiSVO1NF04NjIQvF2u	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl5MESwNEc,OTZ7N{C0NFA9N2F-
BaF3	NYn2NplnSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH31dolv\SCEYV[zJINmdGy\|IHX4dJJme3OrbnegUnBON0GOSzDMNlU3XCCvdYThcpQh[nliW{PIYZRpgW2rZHnu[UB2eHSja3WgZZN{[XluIFnDOVA:QS5zzszNMi=>	Mn7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7N{C0NFAoRjF4OUewOFAxRC:jPh?=
Vero	MkDHRY51cX[rcnHsJIF{e2G7		MkHuN{Bl[Xm\|	NUHUTXBiSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhTGWwZ4XlJJZqenW\|IHnu[oVkfGWmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KF[ncn:gZ4VtdHNiYXTtbY5qe3SncnXkJIJm\m:{ZTD2bZJidCClaHHscIVv\2ViYX\0[ZIhOyCmYYnzJIJ6KH[rcnHsJJBt[XG3ZTDhd5NigQ>?	M3vXdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{[wOlc3Lz5zN{O2NFY4PjxxYU6=
Sf9	M4i3W2Z2dmO2aX;uJIF{e2G7			M2n3OWlvcGmkaYTpc44hd2ZiaIXtZY4hVHmwIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyPUCuNlLPxE1w	M1P6UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{e2OlgxLz5zN{O3OlY5ODxxYU6=
Sf9	MnKzSpVv[3Srb36gZZN{[Xl?			M330dGlvcGmkaYTpc44hd2ZiaIXtZY4hSWKuIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyPUCuOFfPxE1w	NWDVVlUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezO\|Y3QDBpPkG3N\|c3PjhyPD;hQi=>
K562	M4LoN2N6fG:2b4jpZ4l1gSCjc4PhfS=>			MlTWR5l1d3SxeHnjbZR6KGGpYXnud5QhUzV4MjDj[YxteyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD6xPO69VS5?	M{nSb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUeyNFg5Lz5zN{W3NlA5QDxxYU6=
A2780/ADR	Ml72SpVv[3Srb36gZZN{[Xl?			MXTJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIV5eHKnc4Pl[EBqdiCDMke4NE9CTFJiY3XscJMh[nliY3HsZ4VqdiCDTTDhd5NigSxiSVO1NF04NjJ2NEO2{txONg>?	MnPzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OUCwPVQoRjF5OEmwNFk1RC:jPh?=
MO7e	NXzTeYx{TnWwY4Tpc44h[XO\|YYm=			M1rjUWlvcGmkaYTpc44hd2ZiU1PGMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJIMuU2m2IHnuJG1QP2ViY3XscJMh[nliVGKtSnJGXCCjc4PhfUwhUUN3ME2wMlA1Ps7:TT6=	MlPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NEezO\|koRjF6NES3N\|c6RC:jPh?=
MCF7	MXnGeY5kfGmxbjDhd5NigQ>?			NIPjS5JKdmirYnn0bY9vKG:oIFHCR2czKGmwIHj1cYFvKG2rdH;4ZY51em:wZT3y[ZNqe3SjboSgUWNHPyClZXzsd{BjgSCKb3XjbJN1KDN\|M{SyJIF{e2G7LDDJR\|UxRTRwOEm3O\|nPxE1w	NWDPSFlxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2O\|g1QTVpPkG4Olc5PDl3PD;hQi=>
A2780	MoHrSpVv[3Srb36gZZN{[Xl?			M2\s[GlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBi\HKrYX35Z4lvNXKnc3nzeIFvfCCDMke4NEBk\WyuczDifUBJd2WlaIP0JFM{OzR{IHHzd4F6NCCLQ{WwQVcvOjR2M{dOwG0v	NEjqeGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[3PFQ6PSd-MUi2O\|g1QTV:L3G+
CML	NUDkenpqSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			NYD1SmRnSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDUWwh[2WubIOsJGlEPTB;MD6zOe69VS5?	NWnWNY9URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyNVkxOTZpPkG5NlE6ODF4PD;hQi=>
EOL-1	M4HlcGN6fG:2b4jpZ4l1gSCjc4PhfS=>		Mnn2O\|IhcHK\|	Mn;GR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSW9NNTFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwMECwNVk6Pc7:TT6=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
EOL-1	NYL4R3BvS3m2b4TvfIlkcXS7IHHzd4F6		NIjjfYc4OiCqcoO=	MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFU2wuOSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMECy{txONg>?	NGjjO289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
K562	MmfER5l1d3SxeHnjbZR6KGG\|c3H5		MXu3NkBpenN?	M2f5WmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwMES5{txONg>?	NYPK[pEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
K562	NXLXRnhMS3m2b4TvfIlkcXS7IHHzd4F6		NULEcVhHPzJiaILz	M2fNSGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwMd88UU4>	NUHsZmd6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
HCT116	MX3DfZRwfG:6aXPpeJkh[XO\|YYm=		M325[VczKGi{cx?=	MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTFyzszNMi=>	MmDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
RKOp21	M2f2SGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NGe0TVU4OiCqcoO=	M2GyN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJMV3B{MTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MUNOwG0v	NXmxVZE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
RKOp21	MUnDfZRwfG:6aXPpeJkh[XO\|YYm=		NVm5N5Q{PzJiaILz	M2jCdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJMV3B{MTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MUKuOVg6Os7:TT6=	M{L2fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
A549	Ml:yR5l1d3SxeHnjbZR6KGG\|c3H5		NYTTcIxRPzJiaILz	MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS53zszNMi=>	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
MDA-MB-468	M4PrO2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MYS3NkBpenN?	MWLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU45PDh7zszNMi=>	M2m4UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
MDA-MB-468	NHXQbpNEgXSxdH;4bYNqfHliYYPzZZk>		MnjuO\|IhcHK\|	NWm3cFlWS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTgQvF2u	NU\nSlkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
HeLa	MlLXR5l1d3SxeHnjbZR6KGG\|c3H5		NIHYPHQ4OiCqcoO=	NHOzbFNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zOD62Oe69VS5?	NV7XdVljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
Hec1A	NU\HPVJMS3m2b4TvfIlkcXS7IHHzd4F6		MVe3NkBpenN?	MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[YMySSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OToQvF2u	NYW0cIVJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
A549	M2rsRmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MWe3NkBpenN?	Ml7zR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwOUWyOu69VS5?	NHPI[HY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
CAL27	MmPzR5l1d3SxeHnjbZR6KGG\|c3H5		Mo\WO\|IhcHK\|	MYnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwOUWyOu69VS5?	M3r3SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
Hec1A	NHjQZpNEgXSxdH;4bYNqfHliYYPzZZk>		NGr2WlQ4OiCqcoO=	MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[YMySSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTlwOUWyOu69VS5?	NXX0THdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
CAL27	NVKxZpJ7S3m2b4TvfIlkcXS7IHHzd4F6		NF;CdGY4OiCqcoO=	NHmwT5NEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MkNOwG0v	MnzhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
H460	NUnrVY5US3m2b4TvfIlkcXS7IHHzd4F6		NF2y[mo4OiCqcoO=	M3;Rc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTJ2zszNMi=>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
PC3	M3;mR2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M{LsclczKGi{cx?=	MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQR\|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI1\|ryPLh?=	NHLMXHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HCT15	NGHRdG9EgXSxdH;4bYNqfHliYYPzZZk>		M3;BcFczKGi{cx?=	M3\uXGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDF3IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Nd88UU4>	MmLVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
HeLa	MX;DfZRwfG:6aXPpeJkh[XO\|YYm=		NUXqc\|lpPzJiaILz	NWPLeXh3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MkWuNVE5Qc7:TT6=	NGK2SI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H460	MnHGR5l1d3SxeHnjbZR6KGG\|c3H5		MXO3NkBpenN?	MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPS5zMUi5{txONg>?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
HCT15	M4jBW2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NHfBWGc4OiCqcoO=	MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OjVwMUG4Pe69VS5?	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
PC3	MlfYR5l1d3SxeHnjbZR6KGG\|c3H5		MmW0O\|IhcHK\|	Mk\ZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zPS5zMUi5{txONg>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
Saos2	NXP0bGE4S3m2b4TvfIlkcXS7IHHzd4F6		NHPk[Fk4OiCqcoO=	NFnrSZREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBU[W:\|MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MkWuNVE5Qc7:TT6=	Mlr5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
Saos2	NHfMUoREgXSxdH;4bYNqfHliYYPzZZk>		MYO3NkBpenN?	NX3Ce2VsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW2Gxc{KgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUK2{txONg>?	Mn;PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
MCF7	NUDmd2xTS3m2b4TvfIlkcXS7IHHzd4F6		NVjJNpBwPzJiaILz	M{G2UGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTNyzszNMi=>	NIXzPWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
A431	MmL0R5l1d3SxeHnjbZR6KGG\|c3H5		Ml24O\|IhcHK\|	NWT0WVF7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR\|MTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;M{JOwG0v	NYq1SoxiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
H69	MoTTR5l1d3SxeHnjbZR6KGG\|c3H5		NEfWfI84OiCqcoO=	NFnWbYZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPjliY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTNzLk[yNljPxE1w	MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
MCF7	MorUR5l1d3SxeHnjbZR6KGG\|c3H5		Mm\oO\|IhcHK\|	M1u1ZWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTNzLk[yNljPxE1w	M3;HXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
A431	NXfuW\|Q6S3m2b4TvfIlkcXS7IHHzd4F6		MlLSO\|IhcHK\|	M3HIN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTNzLk[yNljPxE1w	NWfyRnA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
H69	NIP3b5hEgXSxdH;4bYNqfHliYYPzZZk>		MkDMO\|IhcHK\|	MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMz\|ryPLh?=	NGLqUog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
CCRF-CEM	M2faOGN6fG:2b4jpZ4l1gSCjc4PhfS=>		Ml3PO\|IhcHK\|	Mn;KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2NTTi2FRV2gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUO2{txONg>?	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
MDA-MB-231	M1vNOGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MlT5O\|IhcHK\|	NEn1U2hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{P87:TT6=	NWW5[JZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
CCRF-CEM/VCR1000	NXLqTWY5S3m2b4TvfIlkcXS7IHHzd4F6		M{OxZ\|czKGi{cx?=	MWPDfZRwfG:6aXPpeJkh[WejaX7zeEB3cW6lcnnzeIlv\S2{ZYPpd5RidnRiaIXtZY4hS0OURj3DSW0wXkOUMUCwNEBk\WyuczDh[pRmeiB5MjDodpMh[nliYXzhcYFzNWKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N\|fPxE1w	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
WM266.4	MmjWR5l1d3SxeHnjbZR6KGG\|c3H5		MlXyO\|IhcHK\|	NEK0Z3REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYVTJ4Nj60JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zO:69VS5?	MlfKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
U87MG	MkTJR5l1d3SxeHnjbZR6KGG\|c3H5		NFq4UXU4OiCqcoO=	M3mzVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5P02JIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1\|ON88UU4>	M2\0XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
SKBR3	NFvzPW9EgXSxdH;4bYNqfHliYYPzZZk>		NV3hWXZzPzJiaILz	NGPiSHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;M{pOwG0v	MnTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
MDA-MB-231	MkTjR5l1d3SxeHnjbZR6KGG\|c3H5		NV;y[2Y6PzJiaILz	M3KzdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjhzMEhOwG0v	NFH5VVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
SKBR3	M4PNUWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NGr6OpA4OiCqcoO=	Mo\5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTN7LkixNFfPxE1w	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
AsPC1	NYPFdodZS3m2b4TvfIlkcXS7IHHzd4F6		MVi3NkBpenN?	Ml:3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRZNRSzFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTN7LkixNFfPxE1w	MoK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CCRF-CEM/VCR1000	M{L2SGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{PoXFczKGi{cx?=	M1HST2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnPybZN1cW6nLYLld4l{fGGwdDDoeY1idiCFQ2LGMWNGVS:YQ2KxNFAxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{QS56MUC3{txONg>?	M1qz[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
CCRF-CEM	NULHTGo2S3m2b4TvfIlkcXS7IHHzd4F6		M3vJTlczKGi{cx?=	NW\nUHNUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0OURj3DSW0h[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM6NjhzMEhOwG0v	MmPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
U87MG	M2HvSWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MXm3NkBpenN?	M3n5S2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5P02JIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1\|OT64NVA4\|ryPLh?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
WM266.4	MWPDfZRwfG:6aXPpeJkh[XO\|YYm=		MUi3NkBpenN?	NGTCVWdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYVTJ4Nj60JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zPU45OTB5zszNMi=>	MmfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
AsPC1	NVjsV3l6S3m2b4TvfIlkcXS7IHHzd4F6		NEnOU4E4OiCqcoO=	MkfTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRZNRSzFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTR2zszNMi=>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
A2780	NY\aXVlnS3m2b4TvfIlkcXS7IHHzd4F6		NV\SWZl3PzJiaILz	Ml7hR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTR6zszNMi=>	NVTVNnFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
HT-29	NV\UVVh{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NXW4OlFPQTZiaILz	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy\|IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5yNt88UU4>	M{nReVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NE[5OVQ4Lz5zOUS2PVU1PzxxYU6=
GIST882	NVr6d3U{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mmi0PVYhcHK\|	NYe3[nhiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{KGGodHXyJFk3KGi{czDifUBUWkJiYYPzZZktKEmFNUC9NU44\|ryPLh?=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4OUW0O{c,OTl2Nkm1OFc9N2F-
HGC27	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MVi5OkBpenN?	NIXqO4VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR\|I4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;Mj60{txONg>?	NV[4ZmtnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olk2PDdpPkG5OFY6PTR5PD;hQi=>
MCF7	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NF[we5Q6PiCqcoO=	NYG4NoEzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MUGuOe69VS5?	NIC3cVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS2PVU1Pyd-MUm0Olk2PDd:L3G+
GIST48	NX[wZXdQS3m2b4TvfIlkcXS7IHHzd4F6		NF\BNng{KHSxIE[g[IF6ew>?	NVHuT\|JZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVES4JINmdGy\|IHHzd4V{e2WmIHHzJIVn\mWldDDvckBk\WyuII\pZYJqdGm2eTDh[pRmeiB\|IITvJFYh\GG7czDifUBtfWOrZnXyZZNmKGKjc3XkJIx2dWmwZYPj[Y5k\SCjc4PhfUwhUUN3ME2xPE44\|ryPLh?=	NGTqTo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS2PVU1Pyd-MUm0Olk2PDd:L3G+
ALL3	MU\DfZRwfG:6aXPpeJkh[XO\|YYm=			Mn\HR5l1d3SxeHnjbZR6KGGpYXnud5QhWGirbHHk[YxxcGmjIHPodo9ud3OxbXWgdI9{cXSrdnWgbJVu[W5iQVzMN{Bk\WyuczDifUBCdGGvYYKgRox2\SCobIXvdoV{[2WwdDDhd5NigSxiSVO1NF0xNjN\|M988UU4>	NVrQWIdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PFk2PDBpPkG5PFg6PTRyPD;hQi=>
MDCK	M2XTc2Z2dmO2aX;uJIF{e2G7			MmH1TY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy\|IHL5JJBp\W:yaH;yZoll\SCDIHHzd4F6NCCLQ{WwQVMvOzkQvF2u	NIHFVXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUmzNlk3OCd-MUm5N\|I6PjB:L3G+
MCF7 MX	Ml31SpVv[3Srb36gZZN{[Xl?			NUf6fnpvUW6qaXLpeIlwdiCxZjDCR3JRKGW6cILld5Nm\CCrbjDNR2Y4KE2[IHPlcIx{KGK7IFjv[YNpe3RiM{OzOFIhe3SjaX7pcoctKEmFNUC9OE4xP87:TT6=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl\|Mkm2NEc,OTl7M{K5OlA9N2F-
KBM5	NHj0OIpEgXSxdH;4bYNqfHliYYPzZZk>		NVnyUI1pPzJiaILz	NEK3XldEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSk13IHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQnPyMWFjdCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOjkQvF2u	M{\qZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUS5OlY2Lz5{MEG0PVY3PTxxYU6=
KBM5	NVPzT4pxS3m2b4TvfIlkcXS7IHHzd4F6		MoL5O\|IhcHK\|	NWDrR217S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0KPNTDj[YxteyCqYYLic5JqdmdiQnPyMWFjdCCWM{G1TUBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13LkVOwG0v	MnexQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEm2OlUoRjJyMUS5OlY2RC:jPh?=
FDC-P1	NHm4SXhHfW6ldHnvckBie3OjeR?=		NXXSdWFLPDhiaILz	MXjJcohq[mm2aX;uJI9nKGi3bXHuJGZOWyCneIDy[ZN{\WRiaX6g[5Jwf3SqIH\hZ5RweiCmZYDlcoRmdnRibX;1d4UhTkSFLWCxJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiRl3TMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBqdiCycnXz[Y5k\SCqdX3hckBEW0ZzIHHmeIVzKDR6IHjyd{BjgSC{ZYPhfpVzcW5iZInlJJJm\HWldHnvckBie3OjeTygTWM2OD1zLkK3OO69VS5?	NITMXZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1OlY5QSd-MkCxOVY3QDl:L3G+
FDC-P1	MlHpSpVv[3Srb36gZZN{[Xl?		NGjKTmQ1QCCqcoO=	MkD4TY5pcWKrdHnvckBw\iCvb4Xz[UBIVS2FU1[td5RqdXWuYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44hd2ZiZ4Lve5RpKG[jY4TvdkBl\XCnbnTlcpQhdW:3c3WgSmRENVBzIHPlcIx{KGW6cILld5NqdmdiaIXtZY4hTk2VIHHmeIVzKDR6IHjyd{BjgSC{ZYPhfpVzcW5iZInlJJJm\HWldHnvckBie3OjeTygTWM2OD16LkSzO:69VS5?	M1vMRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUW2Olg6Lz5{MEG1OlY5QTxxYU6=
K562	MVTGeY5kfGmxbjDhd5NigQ>?		NX;PUGViOiCqcoO=	NHW5b3RKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEBifXSxcHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|LDDJR\|UxRTBwN{ZOwG0v	NIfHU2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG4PFU4QSd-MkCxPFg2Pzl:L3G+
BESM	M2T3RWFvfGm2conwZY5we2:vYXygZZN{[Xl?		NH\xcWM5QCCqcoO=	M4\wbmFvfGm2conwZY5we2:vYXygZYN1cX[rdImgZYdicW6\|dDDUdplx[W6xc3;tZUBkenW8aTDhcYF{fGmpb4Tld{Bqdm[nY4Tl[EBqdiCERWPNJINmdGy\|IH3lZZN2emWmIHHmeIVzKDh6IHjyd{Bxd3O2aX7m[YN1cW:wIHL5JGhVWyCjc4PhfUwhTUN3ME25{txONg>?	NFPTNlQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW0O\|gyQSd-MkC1OFc5OTl:L3G+
BESM	MmXWR5l1d3SxeHnjbZR6KGG\|c3H5		MmPjPFghcHK\|	NYTXRnZZS3m2b4TvfIlkcXS7IHHnZYlve3RiQlXTUUBk\WyuczDh[pRmeiB6ODDodpMh[nliSGTTJIF{e2G7LDDFR\|UxRTN{zszNMi=>	MmjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3NEe4NVkoRjJyNUS3PFE6RC:jPh?=
BA/F3	MkHwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M1H2WmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgVGRITlKkZYThJJRz[W6\|ZnXjeIVlKG2xdYPlJGJCN0Z\|IHPlcIx{NCCLQ{WwQVAvODN7zszNMi=>	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
HEK293	NGDzOopHfW6ldHnvckBie3OjeR?=			NHHtdVVKdmirYnn0bY9vKG:oIHH1eI9xcG:\|cHjvdplt[XSrb36gc4YhTESUMTDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwMESz{txONg>?	M1X4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
A31	NYHubpNjTnWwY4Tpc44h[XO\|YYm=			M2DJR2lvcGmkaYTpc44hd2ZiaIXtZY4hWESJRmLhcJBp[SCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFGzNUBk\WyuczDifUBGVEmVQTygTWM2OD1yLkC3Nu69VS5?	NXzCSVFnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
A31	MnLmSpVv[3Srb36gZZN{[Xl?			NYjNVYJKUW6qaXLpeIlwdiCxZjDQSGdHWmKndHGgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBCOzFiY3XscJMh[nliRVzJV2EtKEmFNUC9NE4xPzMQvF2u	M2nIWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
GIST882	MVjGeY5kfGmxbjDhd5NigQ>?			MlW3TY5pcWKrdHnvckBw\iCqdX3hckBMUVRiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvODl5zszNMi=>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
GIST882	MnH2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S4PFIh[2WubIOsJGlEPTB;MD6xNFjPxE1w	NEXkcWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
HEK293	NYLBVFkzTnWwY4Tpc44h[XO\|YYm=			M1O2RmlvcGmkaYTpc44hd2ZiYYX0c5Bpd3OyaH;yfYxifGmxbjDv[kBFTFJ{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5zNEJOwG0v	Mo\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
Ba/F	MVTGeY5kfGmxbjDhd5NigQ>?			Mny5TY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJGJEWi2DQlyxJIV5eHKnc4Pl[EBqdiCEYT;GJINmdGy\|LDDJR\|UxRTBwMkKx{txONg>?	NGfDbpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
K562	MoPSRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NHzrZplCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOsJGlEPTB;MD6yOFTPxE1w	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
HEK293	M{S1dGZ2dmO2aX;uJIF{e2G7			NVLtSWpLUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKEOVRkHSJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZpkhTUyLU1GsJGlEPTB;MD6yPVHPxE1w	NVjwc3U4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
M-NFS-60	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKE1vTl\TMVYxKGOnbHzzMEBKSzVyPUCuN\|U5\|ryPLh?=	M3;RW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
K562	NFqy[2pHfW6ldHnvckBie3OjeR?=			NUfrNWtuUW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMtKEmFNUC9NE41PzQQvF2u	NWrpfZd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3	MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M2jlemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgRmNTNUGETEGgeJJidnOoZXP0[YQhdW:3c3WgRmEwTjNiY3XscJMtKEmFNUC9NE43PzkQvF2u	MlLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
BA/F3	M2LVTWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NH3zTVJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBud3W\|ZTDCRU9HOyClZXzsd{BqdiCycnXz[Y5k\SCxZjDpcpRmemyndXvpckA{NCCLQ{WwQVkvPDV7zszNMi=>	M1rWVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
K562	MVnDfZRwfG:6aXPpeJkh[XO\|YYm=		MlHxOFghcHK\|	NYXWVYZZS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPTkQvF2u	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NUO4NEc,OjF{OUWzPFA9N2F-
K562	MlfURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NIW4S3ZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHntZZRqdmmkLYLld4l{fGGwdDDLOVYzKGOnbHzzMEBKSzVyPUCuNFA3ODYQvF2u	MorMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|N{[1PFcoRjJzM{e2OVg4RC:jPh?=
KU812	MX\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			Mk\ERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNVUixNkBk\WyuczygTWM2OD1yLkOzO:69VS5?	MlP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF\|N{[1PFcoRjJzM{e2OVg4RC:jPh?=
K562	NUfTO\|NOSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MVfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVA:OC5\|ON88UU4>	M2PQV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{e2OVg4Lz5{MUO3OlU5PzxxYU6=
Sf9	MoPxSpVv[3Srb36gZZN{[Xl?			NFXnfmRDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJIFkfGm4ZTDzbZRmKG:oIF6teIVzdWmwYXygbIV5[Wirc4Tp[Ilv\S22YXfn[YQhSUKOMjDlfJBz\XO\|ZXSgbY4hXHKrY3jvdIx2e2mjIH7pJIlv\mWldHXkJHNnQSClZXzsd{BjgSCrc3;0bIVzdWGuIITpeJJifGmxbjDjZYxwemmvZYTybYMh[XO\|YYmsJGtlRTBwMEC2{txONg>?	M3vkU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEG3N\|Q{Lz5{MUSxO\|M1OzxxYU6=
Sf9	MorMSpVv[3Srb36gZZN{[Xl?			MWPCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlcY91\SC\|aYTlJI9nKE5vdHXycYlv[WxiaHX4ZYhqe3SrZHnu[U11[WepZXSgRWJNOiCneIDy[ZN{\WRiaX6gWJJq[2ixcHz1d4liKG6rIHnu[oVkfGWmIGPmPUBk\WyuczDifUBqe2:2aHXycYFtKHSrdILheIlwdiClYXzvdolu\XS{aXOgZZN{[XluIFvkQVAvPc7:TT6=	M320N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEG3N\|Q{Lz5{MUSxO\|M1OzxxYU6=
K562	MVnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MorkOFghcHK\|	MoLJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PS52zszNMi=>	MmmwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3N{[wNlMoRjJzNUe2NFI{RC:jPh?=
Ba/F3	MYHGeY5kfGmxbjDhd5NigQ>?	NIjnS3gyKHWP	MWqyOEBpenN?	MmPkTY5pcWKrdHnvckBw\iBzND2zMVN{cWevYTDpckBpfW2jbjDCZU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEY4KtRYJtKGOxboP0dpVkfCCjc4Pld5Nm\CCjczDy[Yxm[XOnIH;mJIZ2dGxvbHXu[5RpKGNvQXLsJIZzd21iY4n0c5Bt[XOvaXOgZ49ueGyneDD3bZRpKDF2LUOtN5Nq\22jIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc5Bz\WOrcHn0ZZRqd25xaX3teY5w[myxdDD0[YNpdmmzdXW=	M1:wRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[yOVc3Lz5{MUm2NlU4PjxxYU6=
Ba/F3	M2WxNmZ2dmO2aX;uJIF{e2G7	MmLUNUB2VQ>?	MVKyOEBpenN?	NIL4VVRKdmirYnn0bY9vKG:oIEG0MVMuO3OrZ33hJIlvKGi3bXHuJGJiN0Z\|IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFLjdk1C[mxiY3;ud5RzfWO2IHHzd4V{e2WmIHHzJI52[2ynYYKgbY1xd3K2IH;mJIZ2dGxvbHXu[5RpKGNvQXLsJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IHntcZVvd3C{ZXPpdIl1[XSrb36vbY1ufW6xYnzveEB1\WOqbnnxeYU>	NYfmW4R{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlI2PzZpPkKxPVYzPTd4PD;hQi=>
K562	M{HNWGZ2dmO2aX;uJIF{e2G7		MojLOkBpenN?	MlzZTY5pcWKrdHnvckBw\iCEQ2KtRWJNNW2nZHnheIVlKFOWQWS1JJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IE[gbJJ{KGK7IIDoc5NxcG9vZnzve{BkgXSxbXX0dpk>	Ml3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNEi1PFQoRjJ{MUS4OVg1RC:jPh?=
K562	MV3GeY5kfGmxbjDhd5NigQ>?	MUG0NEB2VQ>?	MUe2JIhzew>?	NEDDV2pKdmirYnn0bY9vKG:oIFLDVk1CSkxvbXXkbYF1\WRiRWLLNUBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gT\|U3OiClZXzsd{BifCB2MDD1UUBi\nSncjC2JIhzeyCkeTDwbI9{eGixLX\sc5ch[3m2b33leJJ6	MkWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNEi1PFQoRjJ{MUS4OVg1RC:jPh?=
K562	M3y3TmZ2dmO2aX;uJIF{e2G7	NHO1N\|A1OCC3TR?=	MoHaOkBpenN?	NHHBTWdKdmirYnn0bY9vKG:oIFLDVk1CSkxvbXXkbYF1\WRiRWLLNkBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gT\|U3OiClZXzsd{BifCB2MDD1UUBi\nSncjC2JIhzeyCkeTDwbI9{eGixLX\sc5ch[3m2b33leJJ6	NHLLUo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0PFU5PCd-MkKxOFg2QDR:L3G+
TF1	MWHDfZRwfG:6aXPpeJkh[XO\|YYm=			NHPITWREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVTjFiY3XscJMh\XiycnXzd4lv\yClLVvJWEBufXSjdHnvckBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUwhUUN3ME2wMlAyO87:TT6=	M{HZPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
primary leukemia cells	M3nnVmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NHHMPHA4OiCqcoO=	MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5Nqdmdid3ns[EB1gXCnIF\MWFMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGlEPTB;MD6x{txONg>?	NHXETlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
primary leukemia cells	M{XG[GN6fG:2b4jpZ4l1gSCjc4PhfS=>		M1q0OFczKGi{cx?=	MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5NqdmdiRlzUN{1FQDN3WTDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG\|ZTDhd5NigSxiSVO1NF0xNjYQvF2u	NHm3dXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
K562	M2LY[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NVzWb41WSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBIUTVyPUCuNVfPxE1w	MoDGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m2O\|QoRjJ{NEO5Olc1RC:jPh?=
HUVEC	MkC5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NEX2bWVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGhWXkWFIHPlcIx{NCCJSUWwQVE5NjYQvF2u	MnHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m2O\|QoRjJ{NEO5Olc1RC:jPh?=
K562	MoDDR5l1d3SxeHnjbZR6KGG\|c3H5		MnvONlQhcHK\|	MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD6x{txONg>?	MljIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4M{K5N\|UoRjJ{NkOyPVM2RC:jPh?=
K562	M{DhbGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NF:xZW01QCC2bzC3NkBpenN?	MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCR3IuSUKOIIDvd4l1cX[nIFu1OlIh[2WubIOgZYZ1\XJiNEigeI8hPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjN6NEVOwG0v	M37CZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{i5OFI6Lz5{Mke4PVQzQTxxYU6=
K562	NWr1OIZCS3m2b4TvfIlkcXS7IHHzd4F6		MY[3NkBpenN?	M1SwNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3ME2wMlM6\|ryPLh?=	NFLaXYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzNlMyOyd-MkK5N\|I{OTN:L3G+
BA/F3	NHPPdopCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MWK3NkBpenN?	M1GzZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGg{QT[SIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OC5zMd88UU4>	M4\kZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BA/F3	MlTURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MmDWO\|IhcHK\|	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDNNlQ1XiCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVAvOTJ7zszNMi=>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3	MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M3X2c\|czKGi{cx?=	MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDFN\|U2TyCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVAvOzZ{zszNMi=>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3	MmXSRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NYrJeYcyPzJiaILz	MlLKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2DYnygUVM2OVRibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NF0xNjR{NN88UU4>	NXLZdZdxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1rITFczKGi{cx?=	M{jkSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGY{PTmYIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OC57Nt88UU4>	Mkn4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
BA/F3	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFzUXpk4OiCqcoO=	NHuxbmNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEB[OjV\|RjDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxRTFwNES0{txONg>?	NXG0XoEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	M2nM[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M3nsNFczKGi{cx?=	NETRdHRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVEvQDN2zszNMi=>	M2fBfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BA/F3	NGDBe4ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MWq3NkBpenN?	NX\MWFYySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTzJ3MFWgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OD1zLki2N:69VS5?	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1vjcVczKGi{cx?=	MYDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDIN\|k3WiCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVIvOzd5zszNMi=>	MnPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
BA/F3	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MnrjO\|IhcHK\|	NU\Z[4g1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTjR6NmOgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OD1{LkW0O:69VS5?	M3XV[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BA/F3	MoXyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MV23NkBpenN?	NHXRd2JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBGOjV3SzDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxRTJwOUWx{txONg>?	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MoXpO\|IhcHK\|	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDUN\|E2USCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVMvODB3zszNMi=>	NH\VVpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
BA/F3	MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkH5O\|IhcHK\|	MlL3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2DYnygVVI2OkhibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NF0{Njd4M988UU4>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3	NG\YNJlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MUm3NkBpenN?	NV62XYFJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTTJ3NW[gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OD16Lk[xOe69VS5?	NYfENY03RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	NV;4[oFkSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mki4O\|IhcHK\|	M4i0dGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJHkzPTOKIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OTdwMEiz{txONg>?	NUTVS45bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	Mn3oRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NWnON5cyPzJiaILz	NXztZpRSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{Bi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUC9NVgvPTMQvF2u	MlO0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
MDCK2	MWrGeY5kfGmxbjDhd5NigQ>?		NYLQZ\|NmPSCvaX7z	M1XVOGlvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRUGtcYVlcWG2ZXSgX\|E1ZS2vZYTmc5JucW5idYD0ZYtmKGW6cILld5Nm\CCrbjDwc4xiemm8ZXSgUWREUzJiY3XscJMh[W[2ZYKgOUBucW6\|IHL5JIxqeXWrZDDzZ4lvfGmubHH0bY9vKGOxdX70bY5oKGGwYXz5d4l{NCCLQ{WwQVAvODUQvF2u	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
HEK293	MVrGeY5kfGmxbjDhd5NigQ>?		MmjLNU42KG2rboO=	M{Da[WlvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRUGtcYVlcWG2ZXSgX\|E1ZS2vZYTmc5JucW5idYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgNU42KG2rboOgZpkhe2OrboTpcIxifGmxbjDjc5VvfGmwZzDhcoFtgXOrczygTWM2OD1yLkC1{txONg>?	MonUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEGwNlkoRjJ\|MkSxNFI6RC:jPh?=
HEK293	M{HjcmZ2dmO2aX;uJIF{e2G7	Mne3OVAxKHWP	NIrRRoMyNjVibXnudy=>	M2jCS2lvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRULLMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMhfXBidH:gOVAxKHWPIHHmeIVzKDFwNTDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1yLkO1{txONg>?	NUL0SGNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
HEK293	NWHRPGVzTnWwY4Tpc44h[XO\|YYm=		NHzzUIoyNjVibXnudy=>	MlLRTY5pcWKrdHnvckBw\iCqdX3hckBOSVSHMT3t[YRq[XSnZDDBV3AsKHWydHHr[UBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIFnfGW{IEGuOUBucW6\|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3ME2wMlM2\|ryPLh?=	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
HEK293	MUDGeY5kfGmxbjDhd5NigQ>?		MmPHNU42KG2rboO=	NH;TVopKdmirYnn0bY9vKG:oIHj1cYFvKE2DVFWyT{1u\WSrYYTl[EBCW1BtIIXweIFs\SCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KGGodHXyJFEvPSCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NF0zNjoQvF2u	MmToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEGwNlkoRjJ\|MkSxNFI6RC:jPh?=
HEK293	NVPSe4VDTnWwY4Tpc44h[XO\|YYm=		NHvHSFA{KG2rboO=	MXXJcohq[mm2aX;uJI9nKGi3bXHuJG9EXDJvbXXkbYF1\WRiQWPQL{B2eHSja3Wg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDh[pRmeiB\|IH3pcpMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR\|UxRTRwMt88UU4>	M3ezNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MkSxNFI6Lz5{M{K0NVAzQTxxYU6=
HEK293	M1TRSWZ2dmO2aX;uJIF{e2G7		MWSzJI1qdnN?	Mn;qTY5pcWKrdHnvckBw\iCqdX3hckBQS1R\|LX3l[IlifGWmIFHTVEshfXC2YXvlJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZYZ1\XJiMzDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1{NT61{txONg>?	NY\ZcGNRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
insect cells	MUfGeY5kfGmxbjDhd5NigQ>?		Mn3HN\|AhdWmwcx?=	MXfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KHerbHSgeJlx\SCDQlyxJIV5eHKnc4Pl[EBqdiCrboPlZ5Qh[2WubIOgZYZ1\XJiM{CgcYlveyCkeTDGVmVVKGG\|c3H5MEBKSzVyPUCuNFk5Os7:TT6=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
insect cells	NX7T[YIyTnWwY4Tpc44h[XO\|YYm=		NFXScGE{OCCvaX7z	M1TMcmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBOOzVzVDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVA:OC5zMUSz{txONg>?	NUjEWGF6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
insect cells	NVzKdG1TTnWwY4Tpc44h[XO\|YYm=		M122TVMxKG2rboO=	NH7GS2RKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhWTJ3MligcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxRTBwMUG1{txONg>?	NWXVbWwyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
insect cells	NX;mSmYzTnWwY4Tpc44h[XO\|YYm=		NVewTVkzOzBibXnudy=>	MXHJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgTFM6PlBibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN\|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwQVAvOTd\|Od88UU4>	NFn5fZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3	Ml\WR5l1d3SxeHnjbZR6KGG\|c3H5		NGS5VFE4OiCqcoO=	NHqz[ZhEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiTUO1NXQhdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NF0xNjJ2zszNMi=>	NXPvVFgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
insect cells	NYfNV4RMTnWwY4Tpc44h[XO\|YYm=		MlznN\|AhdWmwcx?=	NEj6R3VKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhTzJ3MFWgcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxRTBwM{W5Pe69VS5?	NWL2SGUyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
insect cells	NXWxV\|F5TnWwY4Tpc44h[XO\|YYm=		MYOzNEBucW6\|	M{DQNmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBGOjV3SzDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVA:OC52OEW4{txONg>?	M2faOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3	MVjDfZRwfG:6aXPpeJkh[XO\|YYm=		NHzmXWE4OiCqcoO=	NFHpRoNEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDCR3IuSUKOIHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3ME2wMlXPxE1w	NVXiVYppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	MVfDfZRwfG:6aXPpeJkh[XO\|YYm=		M1jlNVczKGi{cx?=	MmnqR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKEV\|NUnWJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUC9NE42Qc7:TT6=	Mnz4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
insect cells	MXPGeY5kfGmxbjDhd5NigQ>?		Ml3sN\|AhdWmwcx?=	NH3ZUVRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhYTJ3M1[gcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxRTBwN{S5Ou69VS5?	NVzme3Y{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	M3HhR2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MmfVO\|IhcHK\|	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKFUj3BRmwhTjR6NmOgcZV1[W62IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3ME2x{txONg>?	NXW4NVF3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	NVy5UZVRS3m2b4TvfIlkcXS7IHHzd4F6		M1fpN\|czKGi{cx?=	NFzoUG5EgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRUO1OWchdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NF0yNjcQvF2u	MonDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
BA/F3	NUO5RY06S3m2b4TvfIlkcXS7IHHzd4F6		NF22PXc4OiCqcoO=	NHXIT4tEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRkOxO2whdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NF0{NjQQvF2u	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
BA/F3	NHrlT5pEgXSxdH;4bYNqfHliYYPzZZk>		M17wflczKGi{cx?=	M3LvSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCTMkWyTEBufXSjboSgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVMvPs7:TT6=	NFOxSJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells	M1T2dGZ2dmO2aX;uJIF{e2G7		Ml;sN\|AhdWmwcx?=	NX:0WIR[UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKFR\|MUXJJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OD13LkG1Oe69VS5?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
BA/F3	M4\lVmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MYO3NkBpenN?	NUPnNoRYS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIFeyOVBGKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:PS5{zszNMi=>	M3vGNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3	NUDBNm9JS3m2b4TvfIlkcXS7IHHzd4F6		NGPJO404OiCqcoO=	M3zSdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCHMkW1T{BufXSjboSgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVUvPs7:TT6=	NGrRS4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3	MnqwR5l1d3SxeHnjbZR6KGG\|c3H5		MnrQO\|IhcHK\|	NIi3bnBEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiWUK1N2YhdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NF06NjMQvF2u	NHfHXpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3	MXvDfZRwfG:6aXPpeJkh[XO\|YYm=		M4Pq[FczKGi{cx?=	M2GwUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCIM{G3WkBufXSjboSgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVkvPc7:TT6=	NFO2dJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3	MkPvR5l1d3SxeHnjbZR6KGG\|c3H5		NFjKR2o4OiCqcoO=	NWDObYNIS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIFizPVZTKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OTFwMd88UU4>	M2rpTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3	NGe0T4NEgXSxdH;4bYNqfHliYYPzZZk>		MnHrO\|IhcHK\|	NX7vdYVrS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIGSzNVVKKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OTJwMt88UU4>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
BA/F3	NILWZXJEgXSxdH;4bYNqfHliYYPzZZk>		NGjPN\|I4OiCqcoO=	NVvObIZiS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIFyyOFhXKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OTJwMt88UU4>	NEfTWWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3	MVPDfZRwfG:6aXPpeJkh[XO\|YYm=		MkHQO\|IhcHK\|	NUXGOo9uS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIGmyOVNJKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVA:OTJwNd88UU4>	NVra[GZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=		NYfnbVN5PzJiaILz	NYHPNZFxS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG\|c3H5MEBKSzVyPUGzMlXPxE1w	M2DaRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3	NFm2cJhCdnSrdIXtc5Ih[XO\|YYm=	M3X4OFUxKG2pL3vn	MXKxOEBl[Xm\|	NWLpNI9nSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yC5aXzkJJR6eGViQlPSMWFDVCCjbHzv[5Ji\nSnZDDpckBUS0mGIH3veZNmKGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhfHWvb4Kg[5Jwf3SqIHH0JFUxKG2pL3vnMEBxdyCzZDDmc5IhOTRiZHH5dy=>	NYLrdJl6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	NF3hXHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MmfURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|LDDJR\|UxRTBwNd88UU4>	NIjQXo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O1NlQ5Oyd-MkOzOVI1QDN:L3G+
BA/F3	MYjDfZRwfG:6aXPpeJkh[XO\|YYm=		MW[0PEBpenN?	NUDrR4xWS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCC5aXzkJJR6eGViQnPyMWFjdCCjZoTldkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwQVAvODl{zszNMi=>	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMEiwOkc,OjN4MEC4NFY9N2F-
K562	Mor6R5l1d3SxeHnjbZR6KGG\|c3H5			MV3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyPUCuNVfPxE1w	NVLSWHVERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFA5ODZpPkKzOlAxQDB4PD;hQi=>
BA/F3	NEfpWlhEgXSxdH;4bYNqfHliYYPzZZk>		NFzuZpc1QCCqcoO=	NH\DSWJEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKEKlcj3BZowhXDNzNVmgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVA:PC55Od88UU4>	NWS1TVAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFA5ODZpPkKzOlAxQDB4PD;hQi=>
Ba/F3	M3rQPWZ2dmO2aX;uJIF{e2G7		Mki3NUBpeg>?	MlXpTY5pcWKrdHnvckBw\iCEY4KtRYJtKFR\|MUXJJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDv[kBxcG:\|cHjvdplt[XSnZDDDdotNKGyndnXsJIFnfGW{IEGgbJIh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMEiwOkc,OjN4MEC4NFY9N2F-
Ba/F3	NVu3bGROTnWwY4Tpc44h[XO\|YYm=		NE\BR4gyKGi{	Mn\BTY5pcWKrdHnvckBw\iCEY4KtRYJtKFR\|MUXJJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDv[kBxcG:\|cHjvdplt[XSnZDDTWGFVPSCuZY\lcEBi\nSncjCxJIhzKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	M3\FSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCwPFA3Lz5{M{[wNFgxPjxxYU6=
Ba/F3	NVmwWo96TnWwY4Tpc44h[XO\|YYm=		M1L3TVEhcHJ?	NFrndmJKdmirYnn0bY9vKG:oIFLjdk1C[mxiVEOxOWkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgdIhwe3Cqb4L5cIF1cW:wIITyZY5{\mWldHXkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGGodHXyJFEhcHJiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	MnX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEC4NFYoRjJ\|NkCwPFA3RC:jPh?=
GIST882	NIXzZZJHfW6ldHnvckBie3OjeR?=			MYjJcohq[mm2aX;uJI9nKEuLVDDLOlQzTSCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIJ6KEWOSWPBMEBKSzVyPUCuNFk4\|ryPLh?=	NFPLc5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xNVc4OSd-MkO2NVE4PzF:L3G+
GIST882	MVnGeY5kfGmxbjDhd5NigQ>?			Ml7iTY5pcWKrdHnvckBw\iCNSWSgT\|Y1OkVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBCXFBvZHXwcIV1cW:wIHHzd4F6NCCLQ{WwQVAvOTB6zszNMi=>	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O\|E9N2F-
32D	MorjSpVv[3Srb36gZZN{[Xl?			MlX3TY5pcWKrdHnvckBw\iCqdX3hckBDS1JvQVLMNUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UA{OkRiY3XscJMtKEmFNUC9NE4yQTUQvF2u	M1zablxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
BA/F3	MmjoSpVv[3Srb36gZZN{[Xl?			MXnJcohq[mm2aX;uJI9nKGi3bXHuJGJEWi2DQlyxJIF2fG:yaH;zdIhwenmuYYTpc44h\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwMkKx{txONg>?	MlvUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O\|EoRjJ\|NkGxO\|cyRC:jPh?=
BA/F3	MWrGeY5kfGmxbjDhd5NigQ>?			NX7mb4RYUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBCXFBvZHXwcIV1cW:wIHHzd4F6NCCLQ{WwQVAvPjd6zszNMi=>	M1z3N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
K562	NG\0VGNEgXSxdH;4bYNqfHliYYPzZZk>		MX20PEBpenN?	NInGN3pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC52N988UU4>	MlrHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{W4NlYoRjJ\|N{O1PFI3RC:jPh?=
GISTT1	NGfuWZJHfW6ldHnvckBie3OjeR?=		NVHlPW9yPzJiaILz	MV;Jcohq[mm2aX;uJI9nKEuLVDDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiR1m1NF0xNjBzzszNMi=>	NHjsU2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e3N\|E2Oyd-MkO3O\|MyPTN:L3G+
GIST48B	MnLFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NYmxNVRWPzJiaILz	M4nhRWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGdKW1R2OFKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiR1m1NF0zOM7:TT6=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd5M{G1N{c,OjN5N{OxOVM9N2F-
K562	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1zKd\|Q5KGi{cx?=	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjYQvF2u	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl\|MkC3NUc,OjN7M{KwO\|E9N2F-
HepG2	M1y5TWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHjnOFAzPCC2bzC5OkBpenN?	MnTuRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB{NDD0c{A6PiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwQVEx\|ryPLh?=	NGnlTXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzNlA4OSd-MkO5N\|IxPzF:L3G+
K562	NEDzUpFEgXSxdH;4bYNqfHliYYPzZZk>		NFPFUZQ4OiCqcoO=	M{DYTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JINidGOnaX6tRW0h[XO\|YYmsJGlEPTB;MD61{txONg>?	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6MUWzNkc,OjN7OEG1N\|I9N2F-
Sf9	M{X5d2Z2dmO2aX;uJIF{e2G7			MXPJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFHicEBscW6jc3WgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hW2Z7IHPlcIx{KHW\|aX7nJGdITUGLWVHBVGZMUyCjczDzeYJ{fHKjdHWgbY4heHKnc3XuZ4Uhd2ZiW3fhcY1iOzOSXVHUVEwhUUN3ME2wMlPPxE1w	M{jhOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
K562	NUn2empzSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYGyOEBpenN?	NFvBRXhKdiC4aYTyc{BidnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgNlQhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2xN:69VS5?	MojMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
BV173	MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mn30NlQhcHK\|	NX71U\|NEUW5idnn0do8h[W62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWlE4OyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIx\|ryPLh?=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUm4Okc,OjR4OEG5PFY9N2F-
CCRF-CEM	NUjtcJMzSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGTmO2kzPCCqcoO=	NHq2OnFKdiC4aYTyc{BidnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPDVmYuS0WPIHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PDYQvF2u	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUm4Okc,OjR4OEG5PFY9N2F-
K562	MYLGeY5kfGmxbjDhd5NigQ>?	NWnjOXFLOTBidV2=	NXrVdmVEOSCqch?=	MkfvTY5pcWKrdHnvckBw\iCEY4KvRYJtKGurbnHz[UB1gXKxc3nu[UBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gT\|U3OiClZXzsd{BifCBzMDD1UUBi\nSncjCxJIhzKGK7IHntcZVvd2Kub4SgZY5idHm\|aYO=	M3rKZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
K562	NIflTmVHfW6ldHnvckBie3OjeR?=	M2WydVExKHWP	NXzmcnZ{OSCqch?=	NXy2XW9vUW6qaXLpeIlwdiCxZjDBZowhc2mwYYPlJJR6em:\|aX7lJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDLOVYzKGOnbHzzJIF1KDFyIIXNJIFnfGW{IEGgbJIh[nliaX3teY5w[myxdDDhcoFtgXOrcx?=	NFfqWo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
K562	NF3EVo5HfW6ldHnvckBie3OjeR?=	MnzWNVAhfU1?	NIXFelUyKGi{	MUHJcohq[mm2aX;uJI9nKHS7cn;zbY5mKHCqb4PwbI9zgWyjdHnvckBw\iCycn;0[YlvKHerdHigcY9t\WO3bHHyJJdmcWeqdDDi[ZR4\WWwIESwJIFv\CB4MDDrSIEhcW5iaIXtZY4hUzV4MjDj[YxteyCjdDCxNEB2VSCjZoTldkAyKGi{IHL5JIludXWwb3Lsc5Qh[W6jbInzbZM>	NY\afZhIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFE6QDZpPkK0OlgyQTh4PD;hQi=>
HGC27	M1O1d2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NXzjfItpPDhiaILz	NXq0TnZCS3m2b4TvfIlkcXS7IHHnZYlve3RiSFfDNlch[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1\|LklOwG0v	NXPnb49yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA2QDRpPkK0PVAxPTh2PD;hQi=>
HMC-1.2	NXq4boQ3SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiPQz2xMlIh[2WubIOgZ4FzenmrbnegWlU3OEduIFS4NVZXKG23dHHueEBie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NF0yP87:TT6=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTByNESwPUc,OjVyMES0NFk9N2F-
K562	NGfndGRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NXL3NJNjPDhiaILz	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLjdk9C[mxicH;zbZRqfmViaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NF01NjF{zszNMi=>	NFOzR2U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2OFg5Pid-MkW0OlQ5QDZ:L3G+
K562	M{DVUGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NUTWVVcyPzJiaILz	MmnFR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNidYPpcochS2GuY3XpckBCVSCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTB;MD61{txONg>?	M3Tu[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{W3OlA{Lz5{NUe1O\|YxOzxxYU6=
K562	NU\HR\|ZxSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2\PNVQ5KGi{cx?=	MnjGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC52N988UU4>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEe2Okc,OjV5N{i3OlY9N2F-
K562	NGTGRo1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnLyO\|IhcHK\|	MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgRoNzNUGkbDDh[pRmeiB5MjDodpMh[nliQ1PLMVgh[XO\|YYmsJGlEPTB;MD6yPO69VS5?	NU\Ld\|JrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xPVUyOzZpPkK2NVk2OTN4PD;hQi=>
K562	MlHuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NEnp[\|c1QCCqcoO=	M4LGUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFwMUdOwG0v	MnjBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{M{GwO\|koRjJ4MkOxNFc6RC:jPh?=
K562	MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M{PjeVQ5KGi{cx?=	NGLWO2FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIlu[XSrbnniMZJme2m\|dHHueEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUWuO:69VS5?	NIr4Tlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKzNVA4QSd-Mk[yN\|ExPzl:L3G+
K562	MlHZR5l1d3SxeHnjbZR6KGG\|c3H5			MnnwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHluIFnDOVA:OC5yNt88UU4>	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
IR-K562	MVLDfZRwfG:6aXPpeJkh[XO\|YYm=			MnXIR5l1d3SxeHnjbZR6KGGpYXnud5QhcW2jdHnubYIhemW\|aYP0ZY51KGi3bXHuJGlTNUt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5MEBKSzVyPUGuNe69VS5?	NF7OR4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK2OFUxOyd-Mk[yOlQ2ODN:L3G+
HEK293	MYPDfZRwfG:6aXPpeJkh[XO\|YYm=			NGW1TYNEgXSxdH;4bYNqfHliYXfhbY5{fCCKRVuyPVMh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6NCCFQ{WwQVgvPM7:TT6=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
U937	MoTHR5l1d3SxeHnjbZR6KGG\|c3H5			MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSxiSVO1NF0yQc7:TT6=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
THP1	NVThPWxJS3m2b4TvfIlkcXS7IHHzd4F6			MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUTHAyKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSxiSVO1NF0zPc7:TT6=	NFLDTWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK2OFUxOyd-Mk[yOlQ2ODN:L3G+
K562	NHvGcoFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NEHJTXY1QCCqcoO=	M122bGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTRwMUNOwG0v	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ7OES5OUc,OjZ{OUi0PVU9N2F-
HCT116	M4PXcmFvfGmlYX7j[ZIh[XO\|YYm=			M2\JdGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUC9N\|QvPM7:TT6=	NYH5[G9ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVI1OzRpPkK2N\|EzPDN2PD;hQi=>
K562	MWLDfZRwfG:6aXPpeJkh[XO\|YYm=		M3fEeVQ5KGi{cx?=	NFr3WpJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGW6cILld5NqdmdiQnPyMWFjdCCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFwMUdOwG0v	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjR3MUe3Nkc,OjZ2NUG3O\|I9N2F-
BA/F3	MnPaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M4S3eFQ5KGi{cx?=	MVrHdo94fGhiaX7obYJqfGmxbjDv[kBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSteJlx\SCEY4KtRYJtKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xQDoQvF2u	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV4MkKxO{c,OjZ3NkKyNVc9N2F-
BA/F3	M4TZSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M4LyZlQ5KGi{cx?=	NUL3RXpXT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCZ5IuSWKuIGSzNVVKKG23dHHueEBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUG0MlXPxE1w	Mkj6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NkKyNVcoRjJ4NU[yNlE4RC:jPh?=
K562	MnXPRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NG\UeYo1QCCqcoO=	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KHS{eYDhckBjdHWnIHT5[UBmgGOudYPpc44h[XO\|YYmsJGlEPTB;MD6yNu69VS5?	NGLR[3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[yPVg2QSd-Mk[2Nlk5PTl:L3G+
K562	NEi5cIhCeG:ydH;zbZMh[XO\|YYm=		Mn7COFghcHK\|	Ml;RTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCjbn7lfIlvXiCjbnSgdJJweGmmaYXtJIlw\GmmZTDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTyfUwhSUN3ME2wMlY5\|ryPLh?=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ{OUi1PUc,OjZ4Mkm4OVk9N2F-
K562	M1rLcmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MoXKOFghcHK\|	MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD61N:69VS5?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjdyN{i0Okc,OjZ5MEe4OFY9N2F-
K562	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=		NHvMOYM4OiCqcoO=	MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDmcJVwemW\|Y3XuZ4UhdWmlcn;wcIF1\SC{ZXHk[ZIhdWW2aH;kMEBKSzVyPUCuO\|PPxE1w	MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5NEG4OVMoRjJ4N{SxPFU{RC:jPh?=
K562	NVzwPVB2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIPiXpE4OiCqcoO=	NYHaZ\|NMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyPUCuNVTPxE1w	NYCxWGpZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
KU812	M3niXWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NV\sUY1nPzJiaILz	MlnQRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OD1yLkG2{txONg>?	NI\uV249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
MEG01	M1G2SmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHyydpg4OiCqcoO=	NXjNPVBuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSWcxOSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3ME2wMlI1\|ryPLh?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3	M3;nN2Z2dmO2aX;uJIF{e2G7		MXe3NkBpenN?	NU\DRYhMUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTB;MD6zPO69VS5?	NVTHVJhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
BA/F3	MUjGeY5kfGmxbjDhd5NigQ>?		NWLR[XpKPzJiaILz	NYDIRoFOUW6qaXLpeIlwdiCxZjDUSWwuVEONIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwQVAvPc7:TT6=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3	MVfGeY5kfGmxbjDhd5NigQ>?		NH3VPIo4OiCqcoO=	MXLJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3NN\|UyXCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTB;MD62NlXPxE1w	M17LW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3	MWTGeY5kfGmxbjDhd5NigQ>?		NHPsWnY4OiCqcoO=	Mn\XTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCtVVI2OkhibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyPUCuOlU6\|ryPLh?=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3	NVLROHVCTnWwY4Tpc44h[XO\|YYm=		MmCzO\|IhcHK\|	MnrYTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCtSlMyP0libYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyPUCuPFU2\|ryPLh?=	MmjJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BA/F3	MXjGeY5kfGmxbjDhd5NigQ>?		M1vzN\|czKGi{cx?=	NX\6OWRKUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAuUDN4OWCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwQVEvPjoQvF2u	NUOzTJFWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
BA/F3	MVLGeY5kfGmxbjDhd5NigQ>?		MV23NkBpenN?	MVHJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3FNlU2UyCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTB;MT65N:69VS5?	M{LXZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3	MWfGeY5kfGmxbjDhd5NigQ>?		M3zMSlczKGi{cx?=	NWezdZJQUW6qaXLpeIlwdiCxZjDUSWwuW1KFIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwQVIvOc7:TT6=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3	MVjGeY5kfGmxbjDhd5NigQ>?		NFTPSo84OiCqcoO=	MUDJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3GN\|E4VCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTB;Mj6xOlnPxE1w	M3vKblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3	NEHL[o5HfW6ldHnvckBie3OjeR?=		M4rnPVczKGi{cx?=	M4n6RmlvcGmkaYTpc44hd2ZiVFXMMWRFWjFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUC9N:69VS5?	NIr5Nos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BA/F3	M4TtRWZ2dmO2aX;uJIF{e2G7		MlnhO\|IhcHK\|	NIPnO3JKdmirYnn0bY9vKG:oIGTFUE1DVEtiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUC9OE4y\|ryPLh?=	NHztUXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
HEL	NVH0c4E{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MVi3NkBpenN?	MmjtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVA:PS5\|zszNMi=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3	MlvjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NVPY[mJtPzJiaILz	NXPkT\|EzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3ME22MlfPxE1w	M4q0TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3	NXPs[HE1TnWwY4Tpc44h[XO\|YYm=		NXHp[VNRPzJiaILz	MXPJcohq[mm2aX;uJI9nKFSHTD3ESHIzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyPUeuO:69VS5?	NFnMV3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BA/F3	M{HwdmZ2dmO2aX;uJIF{e2G7		MkfNO\|IhcHK\|	NG\idotKdmirYnn0bY9vKG:oIGTFUE1JS0tiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUC9PU44\|ryPLh?=	NGPYNHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
Neuro2a	NXvUS\|NUTnWwY4Tpc44h[XO\|YYm=	NVfPO2FtOSC3TR?=		M3;OVWlvcGmkaYTpc44hd2ZiRGKyOEBqdiCGaHPyO{1l\W[rY3nlcpQhdW:3c3WgUoV2em9{YTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckA4NUSKQzDs[ZZmdHNiYYSgNUB2VSCkeTDMR{1OWy:JQz3NV{BidmGueYPpdy=>	MojSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm2OVcoRjJ4N{i5OlU4RC:jPh?=
K562	M3m4OGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MnjDO\|IhcHK\|	NWizSJQ3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvPTIQvF2u	M4\4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEG0PFkxLz5{NkixOFg6ODxxYU6=
K562/G	NXPhcHBDS3m2b4TvfIlkcXS7IHHzd4F6		MVi3NkBpenN?	NH7sOYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{L1egZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01NjZ3zszNMi=>	NYrDS2U4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4NVQ5QTBpPkK2PFE1QDlyPD;hQi=>
BA/F3	Mn7iSpVv[3Srb36gZZN{[Xl?		NVK2fm1TPDhiaILz	NVTBUndCUW6qaXLpeIlwdiCxZjDpcYF1cW6rYj3y[ZNqe3SjboSgVGRITlJiREi0NnYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCFZXzsWIl1\XJiOU[gZZF2\W:3czDvcoUhe2:udYTpc44h[2WubDDwdo9tcW[ncnH0bY9vKGG\|c3H5MEBKSzVyPUCuOlQz\|ryPLh?=	MkHEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NES2PFkoRjJ4OES0Olg6RC:jPh?=
HL60	M4rUS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NIjLeJk4OiCqcoO=	NETjcJJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHO3co\peoFtKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xO87:TT6=	M1vlclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEWwNFA1Lz5{Nki1NFAxPDxxYU6=
K562	M2LLUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MmXyO\|IhcHK\|	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJN2en[rdnHsJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD6zPO69VS5?	NUfkUIEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4OVAxODRpPkK2PFUxODB2PD;hQi=>
KG1a	NUPaUJRnSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIXYbYg4OiCqcoO=	MoKyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNR{HhJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEB{fXK4aY\hcEBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUG2MlfPxE1w	MmPCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NUCwNFQoRjJ4OEWwNFA1RC:jPh?=
293T	MXTDfZRwfG:6aXPpeJkh[XO\|YYm=			M3zG[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFI6O1RiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25uIFPDOVA:OjBwNUROwG0v	M13rTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEWwNFA1Lz5{Nki1NFAxPDxxYU6=
BAF3	NIfVUpVHfW6ldHnvckBie3OjeR?=		MnHvO\|IhcHK\|	NWDG[W85UW6qaXLpeIlwdiCxZjDoeY1idiC5aXzkJJR6eGViQlPSMWFDVCCneIDy[ZN{\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDFR\|UxRTBwMEO0{txONg>?	M3LCN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGwPFExLz5{N{CxNFgyODxxYU6=
JURL-MK1	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mn6wOFghcHK\|	MWHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEqXUlytUWsyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3ME2wMlA3\|ryPLh?=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
BV173	M3vQXGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2\pOVQ5KGi{cx?=	M1r6SGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQm[xO\|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPlcIwuXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBIUTVyPUCuNe69VS5?	NU\wSnpERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
K562	M{DmPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MknLOFghcHK\|	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOnbHytWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDHTVUxRTBwMt88UU4>	M2H4RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGxNVU6Lz5{N{CxNVE2QTxxYU6=
EM2	Ml;6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M{jMZ\|Q5KGi{cx?=	Mn7BRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCHTUKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOnbHytWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDHTVUxRTBwMkdOwG0v	NHzyWpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
KCL22	MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NXHHTmJTPDhiaILz	NXvRU4JKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLR2wzOiClZXzsd{Bi\nSncjC0PEBpenNiYomgR4VtdC2WaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUC9NE41O87:TT6=	NImzXlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
GISTT1	M{n2ZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1fidVczKGi{cx?=	MoHwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDjT2lVKGSncHXu[IVvfCCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVA:OC5yMElOwG0v	NVL1WmNZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
GIST882	MmfYRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYG3NkBpenN?	NUj0[GN3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBkU0mWIHTldIVv\GWwdDDoeY1idiCJSWPUPFgzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyPUCuNFE1\|ryPLh?=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3	MWjGeY5kfGmxbjDhd5NigQ>?		M2TzOlczKGi{cx?=	MX7Jcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUC9NE4xOzoQvF2u	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
MEG01	NI\Jfo5CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NV7DO\|kyPzJiaILz	NWO0b4VJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCR3IuSUKOIHTldIVv\GWwdDDNSWcxOSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3ME2wMlA4PM7:TT6=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3	NWfybXJkTnWwY4Tpc44h[XO\|YYm=		MXG3NkBpenN?	MlfRTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBNPTZ5UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwQVAvOc7:TT6=	NH3XU2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
K562	NIHFOWZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		Ml;zO\|IhcHK\|	NIH1[ZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTB;MD6xNu69VS5?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
KU812	NIizToJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NFXqRYM4OiCqcoO=	NV74XXV4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3ME2wMlE3\|ryPLh?=	NYHLcnBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3	MmroSpVv[3Srb36gZZN{[Xl?		NX\wPWluPzJiaILz	NEPnSW5KdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3ME2wMlTPxE1w	NV3YWJdYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3	NVfINGxMTnWwY4Tpc44h[XO\|YYm=		M2jYNVczKGi{cx?=	MV\Jcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJG45OjKNIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUC9NU4zQc7:TT6=	M1\JclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BAF3	NFn0bIxHfW6ldHnvckBie3OjeR?=		NUO2UHBDPzJiaILz	M3PTc2lvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjZ3NFGgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NF0zNjR7zszNMi=>	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3	NXj3cXB[TnWwY4Tpc44h[XO\|YYm=		M1TMZVczKGi{cx?=	MXfJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGL2[2OVRCKGSxdXLs[UBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxRTQQvF2u	NIHXO5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	M1iyVGZ2dmO2aX;uJIF{e2G7		NUDYXWppPzJiaILz	NYfZXWNnUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCWNkewTU9XPTV7RDDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3ME22MlY4\|ryPLh?=	NHHWTXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
K562	NXnVPFNsS3m2b4TvfIlkcXS7IHHzd4F6			NVvsUIl2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyxiSVO1NF0xNjYQvF2u	NFnpNWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{G4PVY4PCd-MkexPFk3PzR:L3G+
K562	M2XDSGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MoHSO\|IhcHK\|	MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliWGTUJIF{e2G7LDDJR\|UxRTBwM{JOwG0v	NWHHS\|htRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVQ2OTJpPkK3NlE1PTF{PD;hQi=>
A10	MoTTSpVv[3Srb36gZZN{[Xl?		MVK2PEBpenN?	MWXJcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiZILpeoVvKHC{b3zp[oVz[XSrb36gc4YhemG2IFGxNEBk\WyuczDh[pRmeiB4ODDodpMhcW5icILld4Vv[2Vib3[gdoF1KHKnY3;tZolv[W62IGDES2YuSkJiYomgZ4VtdCC2aYTldk1odG9ibIXtbY5me2OnbnPlJIF{e2G7LDDJR\|UxRTBwMU[y{txONg>?	Mm\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3MEK3NFAoRjJ5NUCyO\|AxRC:jPh?=
BA/F3	MofmSpVv[3Srb36gZZN{[Xl?		NYDteYZQPzJiaILz	MXvJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJGw2PjeSIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OD1yLkCx{txONg>?	M33DPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUS1NFQxLz5{N{W0OVA1ODxxYU6=
GIST-T1	M2nZdmZ2dmO2aX;uJIF{e2G7		MoDEO\|IhcHK\|	M1;LOWlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIHPLTXQhcW5iaIXtZY4hT0mVVD3UNUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OD1yLkCyO:69VS5?	NFHXboY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W0OVA1OCd-Mke1OFUxPDB:L3G+
Sf9	M364PWZ2dmO2aX;uJIF{e2G7		MmGyNUBpeg>?	NIfYbJpKdmirYnn0bY9vKG:oIFjpd{11[WepZXSgZ2tKXCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgeZNqdmdiUH;sfUg1QjFiR3z1MEBVgXJrIIDldJRq\GViYYOgd5Vje3S{YYTlJIFnfGW{IEGgbJIh[nliQVTQMYdtdyCtaX7hd4Uh[XO\|YYmsJGlEPTB;MD6zNVnPxE1w	NUL0[\|FZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke1OFUxPDBpPkK3OVQ2ODRyPD;hQi=>
BA/F3	MoruSpVv[3Srb36gZZN{[Xl?		NUKzN5V4PzJiaILz	MnPkTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBPQDJ{SzDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO\|YYmsJGdKPTB;MD6zOu69VS5?	M1n2WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUS1NFQxLz5{N{W0OVA1ODxxYU6=
BA/F3	M3zqZmZ2dmO2aX;uJIF{e2G7		M3PDeFczKGi{cx?=	NGPMdZlKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxRTBwNUpOwG0v	M{TPRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUS1NFQxLz5{N{W0OVA1ODxxYU6=
BA/F3	MUTGeY5kfGmxbjDhd5NigQ>?		NYH1T4JJPzJiaILz	NX7VUpZEUW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCYNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUC9NE44\|ryPLh?=	M3jGdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUS1NFQxLz5{N{W0OVA1ODxxYU6=
BA/F3	M4HvTGZ2dmO2aX;uJIF{e2G7		MY[3NkBpenN?	MlHhTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBXPTV7RD;WOlU1SSCmb4XicIUhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JINmdGxidHn0[ZIu\2yxIHHzd4F6NCCJSUWwQVAvP87:TT6=	MnTkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3NEWwOFAoRjJ5NUS1NFQxRC:jPh?=
BA/F3	NXnS[4dsTnWwY4Tpc44h[XO\|YYm=		NX\ke4NKPzJiaILz	MlrzTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBVPjdyST;WOVU6TCCmb4XicIUhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JINmdGxidHn0[ZIu\2yxIHHzd4F6NCCJSUWwQVUvOs7:TT6=	M13xd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUS1NFQxLz5{N{W0OVA1ODxxYU6=
GIST-5R	MoqySpVv[3Srb36gZZN{[Xl?		NH2yTpA4OiCqcoO=	Mmi0TY5pcWKrdHnvckBw\iC5aXzkJJR6eGViY1vJWEBVPjdySTDteZRidnRiaX6gbJVu[W5iR1nTWE02WiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3ME24MlPPxE1w	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzV2NUC0NEc,Ojd3NEWwOFA9N2F-
BA/F3	MUjGeY5kfGmxbjDhd5NigQ>?		NGHtUnU4OiCqcoO=	NYXDeVJwUW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCWNkewTUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUC9PU43\|ryPLh?=	NH7rZmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W0OVA1OCd-Mke1OFUxPDB:L3G+
Sf9	MYXGeY5kfGmxbjDhd5NigQ>?		M2LKZVEhcHJ?	MUDJcohq[mm2aX;uJI9nKEircz30ZYdo\WRiY1vJWEBVPjdySTDteZRidnRiKEW0OEB1dyB7M{WgdoV{cWS3ZYOpJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyC3c3nu[{BRd2y7KES6NUBIdHVuIGT5dkkheGWydHnk[UBieyC\|dXLzeJJifGViYX\0[ZIhOSCqcjDifUBCTFBvZ3zvJItqdmG\|ZTDhd5NigSxiSVO1NF06NjhzON88UU4>	NFO2XXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{W0OVA1OCd-Mke1OFUxPDB:L3G+
K562	NHfLdVVHfW6ldHnvckBie3OjeR?=	M{TwOlExOCC3TR?=	NVfhUJBHQCCqcoO=	MmjETY5pcWKrdHnvckBw\iCEQ2KtRWJNKHOrZ37hcIlv\yCyYYToe4F6KGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiU2TBWFUheGixc4Doc5J6dGG2aX;uJIF1KDFyMDD1UUBi\nSncjC4JIhzeyCrbjDwdoV{\W6lZTDv[kBO\UKVIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzZ4Nk[zOUc,Ojd4Nk[2N\|U9N2F-
K562	MknFSpVv[3Srb36gZZN{[Xl?	M2fpNFExOCC3TR?=	NHXuNYw5KGi{cx?=	NXzXemZtUW6qaXLpeIlwdiCxZjDCR3IuSUKOIHnuJJNq\26jbHnu[{Bx[XSqd3H5JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhe3WycILld5Nqd25ib3[gR5JsVCCyaH;zdIhwenmuYYTpc44h[XRiMUCwJJVOKGGodHXyJFghcHK\|IHnuJJBz\XOnbnPlJI9nKE2nQmOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	NIWwSJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{[2OlY{PSd-Mke2OlY3OzV:L3G+
K562	MmHhSpVv[3Srb36gZZN{[Xl?	M2LnRVExOCC3TR?=	NWHFRWtzQCCqcoO=	NIHPUGdKdmirYnn0bY9vKG:oIFLDVk1CSkxicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYSgNVAxKHWPIHHmeIVzKDhiaILzJIlvKHC{ZYPlcoNmKG:oIF3lRnMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	NWT3emU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OlY3OzVpPkK3OlY3PjN3PD;hQi=>
GISTT1	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUe3NkBpenN?	NH;ieI9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3RVOSClZXzsd{Bu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG\|c3H5MEBIUTVyPUCuNFA5\|ryPLh?=	M3XvTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M2S5V\|czKGi{cx?=	MorzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCJSWPUPFgzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTB;MD6wNVTPxE1w	MoTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BAF3	Mln2SpVv[3Srb36gZZN{[Xl?		NEL6Nms4OiCqcoO=	Ml;jTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiUFTHSnIu[mW2YTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVA:OC5yMUpOwG0v	MmP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BAF3	M1H1OWZ2dmO2aX;uJIF{e2G7		NFfubpA4OiCqcoO=	Mn22TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiUFTHSnIu[WyyaHGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxRTBwMEO0{txONg>?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BAF3	M13IW2Z2dmO2aX;uJIF{e2G7		MXm3NkBpenN?	MVvJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBXPTV7RDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwQVAvODN7zszNMi=>	NYrLUndKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
MEG01	MoDWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NWXRW2w6PzJiaILz	MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2HR{CxJINmdGy\|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVA:OC5yN{VOwG0v	Ml;LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BAF3	M13ae2Z2dmO2aX;uJIF{e2G7		MVG3NkBpenN?	NHnL[49KdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCCONUe2VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxRTBwMUCy{txONg>?	M2SxPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BAF3	MWjGeY5kfGmxbjDhd5NigQ>?		MYO3NkBpenN?	M1PLTWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3ME2wMlEy\|ryPLh?=	M4e5TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
KU812	MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NHzXXZk4OiCqcoO=	NELWSpBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTB;MD6xOlPPxE1w	NFfBZ\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
SF9	M3;U[GZ2dmO2aX;uJIF{e2G7		NFXIepkyKGi{	NXLOUo1SUW6qaXLpeIlwdiCxZjDDMZRmem2rbnHsJGhqey22YXfn[YQhcHWvYX6gRWJNOSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW0Z7IHPlcIx{KHW\|aX7nJHR6eiByMjDw[ZB1cWSnIHHzJJN2[nO2cnH0[UBu\WG\|dYLl[EBi\nSncjCxJIhzKGK7IF\SSXQh[mG\|ZXSgXkdNgXSnIHHzd4F6NCCLQ{WwQVAvOjJ\|zszNMi=>	NGLKWnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
K562	NF3yW5ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MWC3NkBpenN?	NUi1PGx3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTB;MD6yOlfPxE1w	M3LQbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BAF3	M4P5WGZ2dmO2aX;uJIF{e2G7		NILxOmQ4OiCqcoO=	NXPjc2lGUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NF0xNjJ5zszNMi=>	NInI[2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BAF3	M2\qUmZ2dmO2aX;uJIF{e2G7		NV7FNoxDPzJiaILz	MnT4TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG\|c3H5MEBIUTVyPUCuN\|fPxE1w	MnntQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BAF3	MYrGeY5kfGmxbjDhd5NigQ>?		NIf4fGQ4OiCqcoO=	NVHweow1UW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAh\nW\|aX;uJJBzd3SnaX6gUVM2PlRibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3ME2wMlYzPc7:TT6=	M3yyblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BAF3	Mo\wSpVv[3Srb36gZZN{[Xl?		MnrzO\|IhcHK\|	NYS2OFBkUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAh\nW\|aX;uJJBzd3SnaX6gSlMyP0libYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3ME2wMlg2\|ryPLh?=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BAF3	M1GzTGZ2dmO2aX;uJIF{e2G7		M4nvRlczKGi{cx?=	NVfxV3pxUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ{1MUVRiTkiyNmshdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OD1zLkK5{txONg>?	M1mzcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BAF3	MofmSpVv[3Srb36gZZN{[Xl?		NInLWHY4OiCqcoO=	MYnJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMDDmeZNqd25icILveIVqdiCKM{[5VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxRTFwN{pOwG0v	NFvlV5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BAF3	M3LsNmZ2dmO2aX;uJIF{e2G7		MY[3NkBpenN?	NIHUcIhKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEBnfXOrb36gdJJwfGWrbjDGN\|E4VCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG\|c3H5MEBIUTVyPUKuNVbPxE1w	M4TJZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BAF3	NFLSdFlHfW6ldHnvckBie3OjeR?=		NUTIfoQyPzJiaILz	NEfMR2NKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCCYNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxRTJwNEpOwG0v	NFLYdJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BAF3	MVPGeY5kfGmxbjDhd5NigQ>?		NIfrWZM4OiCqcoO=	Ml3JTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhXjV3OVSvWlY2PEFiZH;1ZoxmKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTB;M988UU4>	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BAF3	Ml\uSpVv[3Srb36gZZN{[Xl?		NUXQSWZzPzJiaILz	MVTJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBVPjdySTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwQVYvPjgQvF2u	MoPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562	MV7D[YxtKGO7Y3zlJIF{e2G7	M{DRV\|EhfU1?	M2PtNVI1KGi{cx?=	MUnD[YxtKGO7Y3zlJIFzemW\|dDDpckBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGGlY4XteYxifGmxbjDheEBIOC:JMTDwbIF{\SCjdDCxJJVOKGGodHXyJFI1KGi{czDifUBxem:yaXTpeY0hcW:maXTlM3JP[XOnIIP0ZYlvcW6pIHLhd4VlKG[ub4egZ5l1d22ndIL5	NH7INVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
KU812	NXzFNIhJS2WubDDjfYNt\SCjc4PhfS=>	NXfHN4M{OSC3TR?=	NU\5OXA5OTJiaILz	M2\MTmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGtWQDF{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG\|ZTDheEAyKHWPIHHmeIVzKDF{IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmN1KQYYPlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
MEG01	M2DJZWNmdGxiY4njcIUh[XO\|YYm=	NHnIbIYyKHWP	NH;IcG0zPCCqcoO=	MYjD[YxtKGO7Y3zlJIFzemW\|dDDpckBpfW2jbjDNSWcxOSClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzBxR{GgdIhie2ViYYSgNUB2VSCjZoTldkAzPCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[U9TVmG\|ZTDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTyfS=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1	MV3D[YxtKGO7Y3zlJIF{e2G7	MkK3NUB2VQ>?	NFvHZmwzPCCqcoO=	NXXwTWR{S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hT0mVVGSxJINmdGy\|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDHNE9IOSCyaHHz[UBifCBzIIXNJIFnfGW{IEK0JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnL2LOZZNmKHO2YXnubY5oKGKjc3XkJIZtd3diY4n0c41mfHK7	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	MlXQR4VtdCCleXPs[UBie3OjeR?=	MYOxJJVO	NVT2OIZ4PDhiaILz	MmDNR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gS2lUXDh6MjDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS\|EheGijc3WgZZQhOSC3TTDh[pRmeiB2ODDodpMh[nlicILvdIllcXWvIHnv[Ill\S:UTnHz[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgQ>?	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
K562	M{XFV2Fxd3C2b4Ppd{Bie3OjeR?=	MojGNUB2VQ>?		NWnCc2FlUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOuZXH2ZYdmKG:oIGDBVnAh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	MmDsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562	NHj2Oo9CeG:ydH;zbZMh[XO\|YYm=	MlLPNUB2VQ>?		M4[y[2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiClbHXheoVlKGOjc4Dhd4UuOyCuZY\lcEBifCBzIIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	Mn7jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
KU812	MlGwRZBweHSxc3nzJIF{e2G7	NF\TblgyKHWP		M1fFS2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS2W4NVIh[2WubIOgZZN{\XO\|ZXSgZZMh[2ynYY\h[4Uhd2ZiUFHSVEBifCBzIIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
KU812	MlrzRZBweHSxc3nzJIF{e2G7	MnPNNUB2VQ>?		MUPJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEuXOEGyJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOuZXH2[YQh[2G\|cHHz[U0{KGyndnXsJIF1KDFidV2gZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	MoHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
MEG01	MY\BdI9xfG:\|aYOgZZN{[Xl?	MVixJJVO		MUfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOuZXH2[YQh[2G\|cHHz[U0{KGyndnXsJIF1KDFidV2gZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	NHKxWVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GISTT1	MoC2RZBweHSxc3nzJIF{e2G7	NYfpWmh5OSC3TR?=		NX;NSI9SUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnLUOgcIV3\WxiYYSgNUB2VSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	M1XhPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
MEG01	MWPBdI9xfG:\|aYOgZZN{[Xl?	NXO1cYpTOSC3TR?=		MUfJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJINt\WG4YXflJI9nKFCDUmCgZZQhOSC3TTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	NYrGPXlkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1	NVjDVVZrSXCxcITvd4l{KGG\|c3H5	M3nCU\|EhfU1?		NEj3eHBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFfJV3RVOSClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDQRXJRKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	NYDCSWxiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	MWnBdI9xfG:\|aYOgZZN{[Xl?	MXixJJVO		NYnUcZVrUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHPs[YF3[WenIH;mJHBCWlBiYYSgNUB2VSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	M2e3dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	Ml\vRZBweHSxc3nzJIF{e2G7	MmLiNUB2VQ>?		MlrhTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIHPs[YF3\WRiY3HzdIF{\S1\|IHzleoVtKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	NHHa[lBHfW6ldHnvckBie3OjeR?=	NYfwN2hoOSC3TR?=	NHLYOYozKGi{cx?=	MVrJcohq[mm2aX;uJI9nKGNvS1nUJI1m\GmjdHXkJJNq\26jbHnu[{Bx[XSqd3H5d{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRWtVKHCqb4PwbI9zgWyjdHnvckBifCCVNEezJIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?=	M3HmVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	M1:1bWZ2dmO2aX;uJIF{e2G7	NUXBdFJPOSC3TR?=	MXiyJIhzew>?	MonuTY5pcWKrdHnvckBw\iClLVvJWEBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGm3NFMhcW5iaIXtZY4hT0mVVGSxJINmdGy\|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne=	M2XBWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	Mkm5SpVv[3Srb36gZZN{[Xl?	NHnabHEyKHWP	NULxcFR{OiCqcoO=	M37ScGlvcGmkaYTpc44hd2ZiYz3LTXQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZO\|E6KGmwIHj1cYFvKEeLU2TUNUBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	NX3RTIs2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1	NXzyTHg{TnWwY4Tpc44h[XO\|YYm=	Mn7xNUB2VQ>?	NGfhXnMzKGi{cx?=	NEPRNI9KdmirYnn0bY9vKG:oIHOtT2lVKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVgzOyCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	NYHZdGF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	NWjqNYZyTnWwY4Tpc44h[XO\|YYm=	MmDiNUB2VQ>?	Ml;LNkBpenN?	Mkj6TY5pcWKrdHnvckBw\iClLVvJWEBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGm3NFMhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	M2[zW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	M2C3cGZ2dmO2aX;uJIF{e2G7	MUWxJJVO	NFTB[WEzKGi{cx?=	MUjJcohq[mm2aX;uJI9nKGNvS1nUJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUexPUBqdiCqdX3hckBIUVOWOEiyJINmdGy\|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	MmC1SpVv[3Srb36gZZN{[Xl?	MVWxJJVO	M2niUFIhcHK\|	NGiwT2VKdmirYnn0bY9vKG:oIHOtT2lVKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVgzOyCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc>	M13NflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	NVu5U2tETnWwY4Tpc44h[XO\|YYm=	MoXWNUB2VQ>?	NV7XdWRoOiCqcoO=	NFP2RXBKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDTOFc{KGmwIHj1cYFvKEeLU2TUNUBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	M2L5UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	NIWyXHBHfW6ldHnvckBie3OjeR?=	NUjCd29sOSC3TR?=	MVWyJIhzew>?	MoHFTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVTUzFxMjDwbI9{eGixconsZZRqd25iYYSgWFIxOi:\MkC0JIlvKGi3bXHuJGdKW1SWMTDj[YxteyCjdDCxJJVOKG2nYYP1doVlKGGodHXyJFIhcHK\|IHL5JIludXWwb3Lsc5R1cW6p	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1	MYnGeY5kfGmxbjDhd5NigQ>?	M{HrOlEhfU1?	M4HKO\|IhcHK\|	NUjISYczUW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC\|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFO2YYSzM\|UheGixc4Doc5J6dGG2aX;uJIF1KFl5MEWvXVY6PCCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	NV7KVGl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1	MUTGeY5kfGmxbjDhd5NigQ>?	M{joN\|EhfU1?	M2mxW\|IhcHK\|	NHfBOpBKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hWzZicHjvd5Bpd3K7bHH0bY9vKGG2IGOyN\|UwOjN4IHnuJIh2dWGwIFfJV3RVOSClZXzsd{BifCBzIIXNJI1m[XO3cnXkJIFnfGW{IEKgbJJ{KGK7IHntcZVvd2Kub4T0bY5o	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1	MkOzSpVv[3Srb36gZZN{[Xl?	NW\vTIVYOSC3TR?=	M3rNblIhcHK\|	NGDuWXBKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hWz[NIIDoc5NxcG:{eXzheIlwdiCjdDDUN\|g6KGmwIHj1cYFvKEeLU2TUNUBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	NV6wb5ZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	MULGeY5kfGmxbjDhd5NigQ>?	NUjH[XlpOSC3TR?=	NGXN[ZAzKGi{cx?=	MVvJcohq[mm2aX;uJI9nKGNvS1nUJI1m\GmjdHXkJJNq\26jbHnu[{Bx[XSqd3H5d{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gV5RifDNxNTDwbI9{eGixconsZZRqd25iYYSgXVcxPS:\Nkm0JIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?=	NEPlWXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882	MVvGeY5kfGmxbjDhd5NigQ>?	MWOxJJVO	NYPG[m9TOiCqcoO=	M1Xjc2lvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBGWktzL{KgdIhwe3Cqb4L5cIF1cW:wIHH0JHQzODJxWUKwOEBqdiCqdX3hckBIUVOWOEiyJINmdGy\|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne=	NWm1[pJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	NX\PN3ZTTnWwY4Tpc44h[XO\|YYm=	NXTLZ4w{OSC3TR?=	NV;5[pRYOiCqcoO=	NGPlXVlKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hWzZicHjvd5Bpd3K7bHH0bY9vKGG2IGOyN\|UwOjN4IHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XRiMTD1UUBu\WG\|dYLl[EBi\nSncjCyJIhzeyCkeTDpcY12dm:kbH;0eIlv\w>?	NVrTdHJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	NFHKXZVHfW6ldHnvckBie3OjeR?=	MUGxJJVO	MXeyJIhzew>?	M4HZVGlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBUPkticHjvd5Bpd3K7bHH0bY9vKGG2IGSzPFkhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
K562	M{jqUWZ2dmO2aX;uJIF{e2G7		Mn\KN\|AhdWmwcx?=	M3TYZWlvcGmkaYTpc44hd2Zia3nuc4Jm[WRiYnnu[Ilv\yC2bzDOVW8zKGmwIHj1cYFvKEt3NkKgZ4VtdHNiaX7jeYJifGWmIH\vdkA{OCCvaX7zJIJ6KGmWUlHRJJJm[WenboStZoF{\WRibXHzd{B{eGWldILvcYV1emmlIH3leIhw\CxiSVO1NF0xNjB2M988UU4>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
K562	Mnu3SpVv[3Srb36gZZN{[Xl?		MmLIN\|AhdWmwcx?=	NUG3XXNzUW6qaXLpeIlwdiCxZjDrbY5w[mWjZDDibY5lcW6pIITvJGRFWjFiaX6gbJVu[W5iS{W2NkBk\WyuczDpcoN2[mG2ZXSg[o9zKDNyIH3pcpMh[nliaWTSRXEhemWjZ3XueE1j[XOnZDDtZZN{KHOyZXP0do9u\XS{aXOgcYV1cG:mLDDJR\|UxRTBwMEpOwG0v	NHu1VGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NFI3OSd-MkiyPFAzPjF:L3G+
K562	MkfuSpVv[3Srb36gZZN{[Xl?		NWDDPGt6OzBibXnudy=>	NH3IXnlKdmirYnn0bY9vKG:oIHvpco9j\WGmIHLpcoRqdmdidH:gRWJNKGmwIHj1cYFvKEt3NkKgZ4VtdHNiaX7jeYJifGWmIH\vdkA{OCCvaX7zJIJ6KGmWUlHRJJJm[WenboStZoF{\WRibXHzd{B{eGWldILvcYV1emmlIH3leIhw\CxiSVO1NF0xNjJ3zszNMi=>	NH31UIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NFI3OSd-MkiyPFAzPjF:L3G+
K562	NHrRSVdHfW6ldHnvckBie3OjeR?=		M3f1fVMxKG2rboO=	NFHCOmxKdmirYnn0bY9vKG:oIHvpco9j\WGmIHLpcoRqdmdidH:gRXJIKGmwIHj1cYFvKEt3NkKgZ4VtdHNiaX7jeYJifGWmIH\vdkA{OCCvaX7zJIJ6KGmWUlHRJJJm[WenboStZoF{\WRibXHzd{B{eGWldILvcYV1emmlIH3leIhw\CxiSVO1NF0xNjJ5Mt88UU4>	M4fST\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiwNlYyLz5{OEK4NFI3OTxxYU6=
K562	M1nNS2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MUi0PEBpenN?	NVLENWpxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MD61N:69VS5?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV{NUizPEc,Ojh3MkW4N\|g9N2F-
A549	NEfsdGlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M2m1clQ5KGi{cx?=	M1jKemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTRwNUdOwG0v	NUHlZndqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5OzhpPkK4OVI2QDN6PD;hQi=>
GISTT1	M3W3U2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGG1em84OiCqcoO=	Mk\hRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCJSWPUWFEh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO\|YYmsJGdKPTB;MD6wNFPPxE1w	NFTYeoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BAF3	M{Dtb2Z2dmO2aX;uJIF{e2G7		NV\XTVh6PzJiaILz	MXXJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoFteGijIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO\|YYmsJGdKPTB;MD6wNVA4\|ryPLh?=	NFvpN4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
GIST882	NVjTV\|duSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NUewZWFrPzJiaILz	NWex[od3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JINmdGxidHn0[ZIu\2yxIHHzd4F6NCCJSUWwQVAvODMQvF2u	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3	NWf5[m5vTnWwY4Tpc44h[XO\|YYm=		MlHiO\|IhcHK\|	MkL2TY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBEPjd2UzDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OD1yLkCyOFnPxE1w	MkHOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3	Mn7iSpVv[3Srb36gZZN{[Xl?		NGH0d4M4OiCqcoO=	NInsSZpKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKFZ3NUnEJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyPUCuNFM3\|ryPLh?=	NFi1VHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
MEG01	Mm\MRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M2DlcVczKGi{cx?=	NFf2PIpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3FS\|AyKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyPUCuNFQ2\|ryPLh?=	NIT2PZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BAF3	NXjoOpI3TnWwY4Tpc44h[XO\|YYm=		M2DlbVczKGi{cx?=	NXzlW2tpUW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCONUe2VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3ME2wMlA1PTIQvF2u	M1ru[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
KU812	MnHpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3\YVlczKGi{cx?=	NInOZphCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyPUCuNVHPxE1w	M{jJfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
K562	M3z1UmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MWO3NkBpenN?	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVA:OC5zNEhOwG0v	MlfDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3	MnntSpVv[3Srb36gZZN{[Xl?		NV76[FV{PzJiaILz	M{\Mb2lvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhSTh{OWCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO\|YYmsJGdKPTB;MD6xOFgz\|ryPLh?=	M4fqbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BAF3	Ml3YSpVv[3Srb36gZZN{[Xl?		MV:3NkBpenN?	NIO4Om1KdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVA:OC5\|OEG5{txONg>?	M3XwOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BAF3	NEnoUFRHfW6ldHnvckBie3OjeR?=		MmrqO\|IhcHK\|	MnLPTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBXPTV7RD;WOlU1SSCmb4XicIUhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUC9NE45ODQQvF2u	NED4NoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BAF3	NFzJXmZHfW6ldHnvckBie3OjeR?=		M37IPVczKGi{cx?=	MoruTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBXPjV2QTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OD1yLkiwN\|HPxE1w	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3	NFXZXo1HfW6ldHnvckBie3OjeR?=		MVq3NkBpenN?	NH7s[JdKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKER6MU\IJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyPUGuNlQ2\|ryPLh?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3	MkjXSpVv[3Srb36gZZN{[Xl?		MV63NkBpenN?	MWnJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJG45OjKNIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxRTFwNE[2{txONg>?	NIjJWHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BAF3	NWXROGx[SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2Hob\|czKGi{cx?=	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVA:PC54OEdOwG0v	NWPzSYk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
GIST48B	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NIHY[mE4OiCqcoO=	Moq1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCJSWPUOFhDKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyPU[uPVg3\|ryPLh?=	M4jL[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BAF3	MWHGeY5kfGmxbjDhd5NigQ>?		Mmr4O\|IhcHK\|	NXzz[\|liUW6qaXLpeIlwdiCxZjDBRmwhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkez{txONg>?	NEX4Spo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm3OFM{QCd-Mki5O\|Q{Ozh:L3G+
BAF3	MnSySpVv[3Srb36gZZN{[Xl?		M2nw[FczKGi{cx?=	NVXXXplrUW6qaXLpeIlwdiCxZjDBRmwhXDNzNVmgcZV1[W62IHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NlAvODQQvF2u	Mlu2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7N{SzN\|goRjJ6OUe0N\|M5RC:jPh?=
GISTT1	M3PyOGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NV3aNmY4PzJiaILz	MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHTXNVXDFiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyS4xwKGG\|c3H5MEBIUTVyPUCuNFTPxE1w	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
GIST430	Mn7xR5l1d3SxeHnjbZR6KGG\|c3H5		NIPSfpY4OiCqcoO=	NILldYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIUVOWNEOwJINmdGy\|IHjhdoJwemmwZzDLTXQhXjZ3NFGgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NF0yNjIQvF2u	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl7MUS2OUc,Ojh7OUG0OlU9N2F-
Sf9	NVvMU\|l1TnWwY4Tpc44h[XO\|YYm=			MkjyRolv\GmwZzDh[oZqdmm2eTD0c{Bz\WOxbXLpcoFvfCCodXzsJIxmdme2aDDoeY1idiCQLYTldo1qdmGuIFfTWE11[WepZXSgV5lsNUuGIDizOVYhfG9iNkO1JJJme2mmdXXzLUBkgXSxcHzhd41q[yCmb33hbY4h\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJHNnQSCrboPlZ5Qh[2WubIOgeZNqdmdicH;sfUBGYSB2OkGgZZMhe3Wkc4TyZZRmNCCNaU21{txONg>?	MoLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzM{K3OVIoRjJ7MUOyO\|UzRC:jPh?=
DAOY	MlHldWhVWyCjc4PhfS=>			MXrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW\|IH\vdkBlenWpIILldJVzeG:\|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDERW9[KGOnbHzz	NYm2UGk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
EOL-1	NVfpUotsSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MlX0O\|IhcHK\|	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWRTD2xJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxRDBwMECx{txONg>?	MmfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
BA/F3	NEXhcVNHfW6ldHnvckBie3OjeR?=		MUC3NkBpenN?	MUHJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoJmfGFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUC9NE4xOToQvF2u	M{TLUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
BA/F3	MnG5SpVv[3Srb36gZZN{[Xl?		NGPENoE4OiCqcoO=	M4PWOmlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIGDES2ZT[WyyaHGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVA:OC5yM{VOwG0v	M4X3U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
NCI-H1703	M361OmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NH;QSVk4OiCqcoO=	NUKxTGhrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF5MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIlvKHC{ZYPlcoNmKG:oIGDES2YuSUFiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3ME2wMlI{\|ryPLh?=	NFvFeWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0OFE1QSd-Mkm1OFQyPDl:L3G+
BA/F3	NWLRbll2TnWwY4Tpc44h[XO\|YYm=		MYi3NkBpenN?	NGSxRW1KdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjMWtKXCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3ME2wMlM4\|ryPLh?=	MoLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
NCI-H1703	NIXKR4lCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHrt[pA4OiCqcoO=	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INVcxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3ME2yMlHPxE1w	M373VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
NCI-H1703	Mn;GSpVv[3Srb36gZZN{[Xl?	NEfFN\|UyKHWP	Mn30NkBpenN?	NITUfFBKdmirYnn0bY9vKG:oIGDES2YucW6mdXPl[EBRTEeIUnHsdIhiKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVExOThicnXzbYR2\SCrbjDoeY1idiCQQ1mtTFE4ODNiY3XscJMh[XRiMTD1UUBi\nSncjCyJIhzeyCrbjDwdoV{\W6lZTDv[kBRTEeILVHBJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
NCI-H1703	MYjGeY5kfGmxbjDhd5NigQ>?	NETifFkyKHWP	M1P1cFIhcHK\|	NUfEd2ZjUW6qaXLpeIlwdiCxZjDQSGdHNWmwZIXj[YQhWESJRmLhcJBp[SCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHk4PTRicnXzbYR2\SCrbjDoeY1idiCQQ1mtTFE4ODNiY3XscJMh[XRiMTD1UUBi\nSncjCyJIhzeyCrbjDwdoV{\W6lZTDv[kBRTEeILVHBJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	M1TtUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
NCI-H1703	NX3i[\|Y3TnWwY4Tpc44h[XO\|YYm=	M3fKflEhfU1?	M3PlOFIhcHK\|	NEDGO4VKdmirYnn0bY9vKG:oIGDES2YucW6mdXPl[EBRTEeIUnHsdIhiKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVg1QSC{ZYPp[JVmKGmwIHj1cYFvKE6FST3INVcxOyClZXzsd{BifCBzIIXNJIFnfGW{IEKgbJJ{KGmwIIDy[ZNmdmOnIH;mJHBFT0ZvQVGgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	NHTMXok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0OFE1QSd-Mkm1OFQyPDl:L3G+
EOL-1	Mo\3SpVv[3Srb36gZZN{[Xl?	NIrMTo8yKHWP	NHTB[5czKGi{cx?=	M1;jcmlvcGmkaYTpc44hd2ZiUFTHSnJidHCqYTDpckBpfW2jbjDFU2wuOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDTWGFVPSCyaH;zdIhwenmuYYTpc44h[XRiWU[5OEBz\XOrZIXlJIF1KDFidV2gZYZ1\XJiMjDodpMhcW5icILld4Vv[2Vib3[gVGRITi2DQTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	MlP0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
EOL-1	NV[ydYxNTnWwY4Tpc44h[XO\|YYm=	MY[xJJVO	MmruNkBpenN?	NXvPZoZ1UW6qaXLpeIlwdiCxZjDQSGdHWmGucHjhJIlvKGi3bXHuJGVQVC1zIHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJGVTUyCyaH;zdIhwenmuYYTpc44h[XRiVEKwNk9[OjB2IILld4llfWW\|IHH0JFEhfU1iYX\0[ZIhOiCqcoOgbY4heHKnc3XuZ4Uhd2ZiUFTHSk1CSSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
K562	MnjoR5l1d3SxeHnjbZR6KGG\|c3H5		NX\1W2llPDhiaILz	NUfjbFRqS3m2b4TvfIlkcXS7IHnuJIRzfWdic3Xud4l1cX[nIHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NF0yNjIQvF2u	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3NUm4NUc,Ojl4NUW5PFE9N2F-
K562	NF3VPGJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MX63NkBpenN?	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0{NjR\|zszNMi=>	NVHjUVY5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFQ4ODhpPkK5Olg1PzB6PD;hQi=>
MCF7	MmrhRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Ml7CO\|IhcHK\|	Mn7SRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPQ1[3JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Py5zMt88UU4>	MkizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OES3NFgoRjJ7Nki0O\|A5RC:jPh?=
A2780	NXfCbHVPSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MnfLO\|IhcHK\|	NUTQTmdWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUiuPe69VS5?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6NEewPEc,Ojl4OES3NFg9N2F-
HCT116	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MYq3NkBpenN?	M1Hp[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MUmuOlbPxE1w	M4LxS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nki0O\|A5Lz5{OU[4OFcxQDxxYU6=
HT-29	MnflRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MmPUPVYhcHK\|	M12yNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1yLkC2{txONg>?	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd{NE[1N{c,Ojl5MkS2OVM9N2F-
GIST882	M1rGSWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGLNcnk6PiCqcoO=	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHntZZRqdmmkLYP1d4NmeHSrYnzlJIh2dWGwIFfJV3Q5QDJiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJGs3PDKHIH31eIFvfCCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVEvP87:TT6=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd{NE[1N{c,Ojl5MkS2OVM9N2F-
HGC27	NUm5[5ZbSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mn\aPVYhcHK\|	MlrORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKR1OyO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR\|UxRTJwNN88UU4>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd{NE[1N{c,Ojl5MkS2OVM9N2F-
MCF7	NF3HXZdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NFfaUY06PiCqcoO=	NVjxPIpRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTB;MUGuN:69VS5?	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd{NE[1N{c,Ojl5MkS2OVM9N2F-
GIST48	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NUTMe3huQTZiaILz	MmDKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDpcYF1cW6rYj3y[ZNqe3SjboSgbJVu[W5iR1nTWFQ5KGOnbHzzJIhiemKxcnnu[{BkNUuLVDDWOVYxTC:GOEKwRUBld3WkbHWgcZV1[W62IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OTlwON88UU4>	NE\u[Y49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUeyOFY2Oyd-Mkm3NlQ3PTN:L3G+
Ba/F3	NIftOHpHfW6ldHnvckBie3OjeR?=		NHe5eVQ1QCCqcoO=	M3vWe2lvcGmkaYTpc44hd2ZiQlPSMWFDVDFiR{K1NGghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUC9NE4xPzdzzszNMi=>	NYPrOmdIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Ba/F3	NFfmfI1HfW6ldHnvckBie3OjeR?=		Mn6yOFghcHK\|	MmXHTY5pcWKrdHnvckBw\iC5aXzkJJR6eGViQlPSMWFDVDFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQnGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IFLybZRmVGmpaISgcJVkcW[ncnHz[UBie3OjeTygS2k2OD1yLkC5NFXPxE1w	M4ixSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
Ba/F3	NWPpR\|ZbTnWwY4Tpc44h[XO\|YYm=		NXfjfHdqPDhiaILz	MonRTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCHM{W1S{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK\|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3ME2wMlE1Qc7:TT6=	NU\nPGg1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Ba/F3	MnvrSpVv[3Srb36gZZN{[Xl?		NF;Nd3Q1QCCqcoO=	MWDJcohq[mm2aX;uJI9nKEKFUj3BRmwyKEV2NUnLJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGJEWi2DQlyxMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgRpJqfGWOaXfoeEBtfWOrZnXyZZNmKGG\|c3H5MEBIUTVyPUCuNlAy\|ryPLh?=	M{flXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
Ba/F3	MmmzSpVv[3Srb36gZZN{[Xl?		NFXFZpU1QCCqcoO=	NIi0SXVKdmirYnn0bY9vKG:oIFLDVk1CSkxzIF[zOVlXKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwQVAvOjR7zszNMi=>	NETsbpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
Ba/F3	NWDXRmc2TnWwY4Tpc44h[XO\|YYm=		NXTydZNPPDhiaILz	MXnJcohq[mm2aX;uJI9nKEKFUj3BRmwyKFF{NULIJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGJEWi2DQlyxMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgRpJqfGWOaXfoeEBtfWOrZnXyZZNmKGG\|c3H5MEBIUTVyPUCuOFU2\|ryPLh?=	MlrJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
Ba/F3	MXzGeY5kfGmxbjDhd5NigQ>?		M3fVfVQ5KGi{cx?=	NIH1cIJKdmirYnn0bY9vKG:oIFLDVk1CSkxzIGmyOVNJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwQVAvQDN4zszNMi=>	NUO4N2dZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Ba/F3	M3PmOWZ2dmO2aX;uJIF{e2G7		MUO0PEBpenN?	M3zJ[WlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRUK1OWshdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUC9NE45OzkQvF2u	Mn3RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
Ba/F3	Mn3iSpVv[3Srb36gZZN{[Xl?		NGjTN3g1QCCqcoO=	M1HyWGlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRUK1OXYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUC9NE45PzUQvF2u	MmCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
Ba/F3	MkfpSpVv[3Srb36gZZN{[Xl?		NVz3d4hlPDhiaILz	M4jvbmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiVEOxOWkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUC9PU43PDYQvF2u	NX\nXZN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
BA/F3	MYHGeY5kfGmxbjDhd5NigQ>?		M{T0bFczKGi{cx?=	M3PqemlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxRTBwMEG3{txONg>?	MoS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	MnXiSpVv[3Srb36gZZN{[Xl?		MmGzO\|IhcHK\|	NH\2UoVKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmGucHjhJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVA:OC5yNEdOwG0v	NEfqfJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3	M{X6R2Z2dmO2aX;uJIF{e2G7		Ml3lO\|IhcHK\|	MknXTY5pcWKrdHnvckBw\iCNaYSgWlU3OERibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTB;MD6wO:69VS5?	MmrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	NWPqeG53TnWwY4Tpc44h[XO\|YYm=		NXTyVlk1PzJiaILz	Mn\yTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJj\XSjIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUC9NE4yODMQvF2u	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	NV3Tc3dsTnWwY4Tpc44h[XO\|YYm=		MYq3NkBpenN?	NHWwS5VKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEmgRXk2ODJidH:gOVA{KGmwc3XyeIlwdiCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OD1yLkG5Nu69VS5?	NF3Md3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3	NFPVV\|BHfW6ldHnvckBie3OjeR?=		NV[w[W9FPzJiaILz	NVjHV2dsUW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OjCDIH31eIFvfCCjbnSgSFgzOEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTB;MD6yNVbPxE1w	NEHmTI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3	NUm0ToVsTnWwY4Tpc44h[XO\|YYm=		NILwV2k4OiCqcoO=	M{\rRmlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKGGwZDDOPFIzUyCvdYThcpQh[W6mIGm4NlNFKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxRTBwMkKz{txONg>?	NUjJNllMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	MoXjSpVv[3Srb36gZZN{[Xl?		NYnJR2JKPzJiaILz	NGS2c3hKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgRVgzQVBibYX0ZY51KGGwZDDZPFI{TCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OD1yLkOxNu69VS5?	NXzEenNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	NVnPT4Z7TnWwY4Tpc44h[XO\|YYm=		NITMeYI4OiCqcoO=	MlHkTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIG[2OVRCKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxRTBwM{my{txONg>?	NVjMUlFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	NYS3bFB[TnWwY4Tpc44h[XO\|YYm=		Ml3sO\|IhcHK\|	NYjYbVdxUW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OT[KIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIghcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyPUCuOVM2\|ryPLh?=	NV7xV3JURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	NFnzdolHfW6ldHnvckBie3OjeR?=		M3LMb\|czKGi{cx?=	MoHiTY5pcWKrdHnvckBw\iCSRFfGVoFteGijIG[1OlFFN0R6NELWJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwQVAvPTZ5zszNMi=>	MnroQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	NHP3S49HfW6ldHnvckBie3OjeR?=		MmnxO\|IhcHK\|	M4TuOmlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKGGwZDDZPFI{TCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OD1yLk[2Pe69VS5?	MlXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	NVfaT3hWTnWwY4Tpc44h[XO\|YYm=		MUC3NkBpenN?	M4PBdGlvcGmkaYTpc44hd2ZiS3n0JHY2PjCGL2[2OVRCKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxRTBwN{Cx{txONg>?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	NGK2dIhHfW6ldHnvckBie3OjeR?=		NXvJU4pVPzJiaILz	NHnWUIFKdmirYnn0bY9vKG:oIFvpeEBXPTZyRD;EPFE3UCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OD1zLkG5Ne69VS5?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	NITndodHfW6ldHnvckBie3OjeR?=		NYXyeI9nPzJiaILz	M1HMZWlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU3OCC2bzC1O\|ghemW\|aXT1[ZMqKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxRTFwNUKz{txONg>?	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	NH\xbZhHfW6ldHnvckBie3OjeR?=		Mn3nO\|IhcHK\|	NH\yUIdKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEmgRXk2ODJidH:gOVA{KGmwc3XyeIlwdiCjbnSgSFgyPiCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OD1{Lke0Pe69VS5?	NVLVNYlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	NGPiSmZHfW6ldHnvckBie3OjeR?=		MnjVO\|IhcHK\|	MV;Jcohq[mm2aX;uJI9nKEurdDDlfI9vKDliQWm1NFIhfG9iNUCzJIlve2W{dHnvckBidmRiVk[1OEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NF0{Njl2N988UU4>	NGTnc3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3	M{S1SmZ2dmO2aX;uJIF{e2G7		M3LLclczKGi{cx?=	NXLqO3k{UW6qaXLpeIlwdiCxZjDLbZQhTDhzNm[gcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUC9PU46O87:TT6=	NUG5U5NSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
K562	NEnjXZpEgXSxdH;4bYNqfHliYYPzZZk>		NEnOc20zPCCqcoO=	NF;lXWlEgXSxdH;4bYNqfHliYXfhbY5{fCCrbXH0bY5q[i2\|ZX7zbZRqfmViaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB{NDDodpMh[nliWGTUJIF{e2G7LDDJR\|UxRTIQvF2u	MoGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{NkG0OlgoRjNyMk[xOFY5RC:jPh?=
K562	NH7KWm1HfW6ldHnvckBie3OjeR?=	MmDYNUB2VQ>?		NFnyZnFKdmirYnn0bY9vKG:oIFLDVk1CSkxiaX6gbY1ifGmwaXKtd4Vve2m2aY\lJIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iQ4LLUEBxcG:\|cHjvdplt[XSrb36gZZQhOSC3TTDifUBqdW23bn:gZoxwfCCjbnHsfZNqew>?	NFjCOVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEK2NVQ3QCd-M{CyOlE1Pjh:L3G+
Sf9	NFrIZVVHfW6ldHnvckBie3OjeR?=		NFrIOoo3OCCvaX7z	NV7tdW5pUW6qaXLpeIlwdiCxZjDpcoFkfGm4ZTD3bYxlKHS7cHWgTIl{NXSjZ3fl[EBCSkxiKEKyPUB1dyB3MECgdoV{cWS3ZYOpJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIIPmPUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iYYX0c5Bpd3OyaH;yfYxifGmxbjDwdoVqdmO3YnH0[YQh\m:{IE[wJI1qdnNiZn;scI94\WRiYomgRXRRKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFghcHK\|IHL5JGFFWC2JLDDJR\|UxRTBwMESz{txONg>?	NI\hOG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEOxO\|AzPid-M{CzNVcxOjZ:L3G+
K562	NHj6UmlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NXvSUVZ1PzJiaILz	NV\hW5hxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhcW5iaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjJ3zszNMi=>	M3vvbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{G3NFI3Lz5\|MEOxO\|AzPjxxYU6=
BAF3	NHfEemtHfW6ldHnvckBie3OjeR?=		M2fGV\|czKGi{cx?=	NGnhfoVKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDDMZRmem2rbnHsJGZNSUdvdHHn[4VlKGi3bXHuJHRGVCCodYPl[EBCSkxiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0t6IHHzd4F6NCCJSUWwQVAvOjcQvF2u	Mof3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB\|MUewNlYoRjNyM{G3NFI3RC:jPh?=
MEG01	M3j6emFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MVq3NkBpenN?	NFjGcZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBqdiCqdX3hckBOTUdyMTDj[YxteyCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjJ6zszNMi=>	NFm0cm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEOxO\|AzPid-M{CzNVcxOjZ:L3G+
BAF3	MX\GeY5kfGmxbjDhd5NigQ>?		M2DXc\|czKGi{cx?=	NHriZ4xKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDCR3IwSUKOIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjJ7zszNMi=>	NFLwdpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEOxO\|AzPid-M{CzNVcxOjZ:L3G+
KU812	M13kSmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHLafVU4OiCqcoO=	M3;sTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIlvKGi3bXHuJGtWQDF{IHPlcIx{KGGodHXyJFczKGi{czDifUBES0t6IHHzd4F6NCCJSUWwQVAvOzIQvF2u	Ml;5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB\|MUewNlYoRjNyM{G3NFI3RC:jPh?=
BAF3	MoX1SpVv[3Srb36gZZN{[Xl?		MnX3O\|IhcHK\|	Mn\3TY5pcWKrdHnvckBw\iCEQ2KvRWJNKFZ{OUnMJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:OC54Nd88UU4>	MnjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB\|MUewNlYoRjNyM{G3NFI3RC:jPh?=
BAF3	MoXzSpVv[3Srb36gZZN{[Xl?		MmrXO\|IhcHK\|	MX3Jcohq[mm2aX;uJI9nKEKFUj;BRmwhVTN3MWSgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjh3zszNMi=>	NU\vUFlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVcxOjZpPkOwN\|E4ODJ4PD;hQi=>
BAF3	MoTESpVv[3Srb36gZZN{[Xl?		MUm3NkBpenN?	NV7RfFc2UW6qaXLpeIlwdiCxZjDCR3IwSUKOIF[zNVdKKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGdKPTB;MD65Oe69VS5?	NF7md4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEOxO\|AzPid-M{CzNVcxOjZ:L3G+
BAF3	MVrGeY5kfGmxbjDhd5NigQ>?		NIXCNVc4OiCqcoO=	NVfWTXhJUW6qaXLpeIlwdiCxZjDCR3IwSUKOIGGyOVJJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGdKPTB;MT6xO:69VS5?	NWewcW1MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzNVcxOjZpPkOwN\|E4ODJ4PD;hQi=>
Sf9	NH7PfWNHfW6ldHnvckBie3OjeR?=		NV\kOnpiOSCqch?=	NV3Y[mtKUW6qaXLpeIlwdiCxZjDhZ5RqfmVid3ns[EB1gXCnIFjpd{11[WepZXSgRWJNKCh{MkmgeI8hPTByIILld4llfWW\|KTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CC\|ZkmgZ4VtdHNidYPpcochSUKOdHnk[UBieyC\|dXLzeJJifGViYX\0[ZIhOSCqcjDifUBCTFBvR3zvJIF{e2G7LDDJR\|UxRTFwNd88UU4>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODNzN{CyOkc,OzB\|MUewNlY9N2F-
BAF3	MnfWSpVv[3Srb36gZZN{[Xl?		MX:3NkBpenN?	NF\ZeYRKdmirYnn0bY9vKG:oIFLDVk9CSkxiRkOxO2whdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD1{LkK0{txONg>?	MmfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB\|MUewNlYoRjNyM{G3NFI3RC:jPh?=
BAF3	NGfVWXdHfW6ldHnvckBie3OjeR?=		Mn;uO\|IhcHK\|	MmTuTY5pcWKrdHnvckBw\iCEQ2KvRWJNKEh\|NknQJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:Oy55Nd88UU4>	Ml3uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB\|MUewNlYoRjNyM{G3NFI3RC:jPh?=
HCT116	NFLkOohCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MlG2O\|IhcHK\|	NW\5dYVGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBxPTNtLzugbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKgPVYh[XG3ZX;1d{BwdmVic3;seZRqd25iYYPzZZktKEmFNUC9OFQvPTYQvF2u	M{e1RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNU[yOlk4Lz5\|MEW2NlY6PzxxYU6=
K562	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MmjLO\|IhcHK\|	M2mzcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwMECwNVXPxE1w	M1PiS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkC1PFMyLz5\|ME[wOVg{OTxxYU6=
MCF7	NVfOVIpHS3m2b4TvfIlkcXS7IHHzd4F6		NV7zRpVyPDhiaILz	MoTBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVYvOzQQvF2u	Ml3mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5OUiwOFkoRjNyN{m4NFQ6RC:jPh?=
MDA-MB-453	M3\GVWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MnTDOFghcHK\|	M4rGbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1FSS2PQj20OVMh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNk45PM7:TT6=	MlrtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB5OUiwOFkoRjNyN{m4NFQ6RC:jPh?=
GIST882	NH:5fFVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			M4j1dWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{Bp[XKkb4Lpcoch[y2NSWSg[ZhwdiBzMzDoc41wgnmpb4XzJJBzcW2jcomgT\|Y1OkVibYX0ZY51KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDifUBOXFNiYYPzZZktKEeLNUC9NE4yQTYQvF2u	NXfTdoUxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5Olg3QTNpPkOwPVY5Pjl\|PD;hQi=>
GIST882	NFPBOplCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NIjQZW9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q5QDJiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJIV5d25iMUOgbI9ud3q7Z3;1d{BxemmvYYL5JGs3PDKHIH31eIFvfCCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgZpkhdWW2aIns[Y5mKGKudXWgd5RicW6rbnegZoF{\WRiYYPzZZktKEeLNUC9NE4yQTYQvF2u	M2rWR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOU[4Olk{Lz5\|MEm2PFY6OzxxYU6=
GIST48	MlW5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M1HIOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFQ5KGOnbHzzJIhiemKxcnnu[{BkNUuLVDDlfI9vKDFzIHjvcY97gWexdYOgdJJqdWG{eTDtbZN{\W6\|ZTDWOVYxTCCvdYThcpQh[W6mIHX4c44hOTdiaHX0[ZJwgnmpb4XzJJNm[2:wZHHyfUBFQDJyQTDteZRidnRiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIJ6KE2WUzDhd5NigSxiR1m1NF0xNjZ{Nd88UU4>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl4OE[5N{c,OzB7Nki2PVM9N2F-
GIST48	MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M4nyd2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFQ5KGOnbHzzJIhiemKxcnnu[{BkNUuLVDDlfI9vKDFzIHjvcY97gWexdYOgdJJqdWG{eTDtbZN{\W6\|ZTDWOVYxTCCvdYThcpQh[W6mIHX4c44hOTdiaHX0[ZJwgnmpb4XzJJNm[2:wZHHyfUBFQDJyQTDteZRidnRiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIJ6KG2ndHj5cIVv\SCkbIXlJJN1[WmwaX7nJIJie2WmIHHzd4F6NCCJSUWwQVAvPjJ3zszNMi=>	M3:xflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOU[4Olk{Lz5\|MEm2PFY6OzxxYU6=
Sf9	MVzGeY5kfGmxbjDhd5NigQ>?			Mk\sTY5pcWKrdHnvckBw\iC3bnHjeIl3[XSnZDDy[YNwdWKrbnHueEBpfW2jbjDOMZRmem2rbnHsJFZ5NUircz30ZYdo\WRiYz3LTXQhMDV2NzD0c{A6OzVicnXzbYR2\XNrLzi2PVQhfG9iN{WzJJJme2mmdXXzJIRmdGW2aX;uLUBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4Y6KGmwc3XjeEBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCyb3z5JEhIdHVuVInyLUA1QjFicHjvd5Bpd3K7bHH0bY9vNCCLQ{WwQVAvPzZ7zszNMi=>	M2fSTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOU[4Olk{Lz5\|MEm2PFY6OzxxYU6=
GIST430	M4TRTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NH;FbHZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q1OzBiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJIV5d25iMUGgdJJqdWG{eTDpck1nemGvZTDWOVYxNUx3N{[g[IVt\XSrb36gcZV1[W62IHHu[EBmgG:wIEGzJIhmfGW{b4r5[492eyC\|ZXPvcoRienlibXnzd4Vve2ViVk[1OGEhdXW2YX70JIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCkeTDNWHMh[XO\|YYmsJGdKPTB;MD65NlnPxE1w	MlztQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7Nki2PVMoRjNyOU[4Olk{RC:jPh?=
GIST430	NI\YUlhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MnjORY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCJSWPUOFMxKGOnbHzzJIhiemKxcnnu[{BkNUuLVDDlfI9vKDFzIIDybY1ienliaX6t[pJidWViVkW2NE1NPTd4IHTlcIV1cW:wIH31eIFvfCCjbnSg[ZhwdiBzMzDo[ZRmem:8eXfveZMhe2Wlb37kZZJ6KG2rc4PlcpNmKFZ4NUTBJI12fGGwdDDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[nlibXX0bJlt\W6nIHLseYUhe3SjaX7pcoch[mG\|ZXSgZZN{[XluIFfJOVA:OC57MkpOwG0v	NUDZVFl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5Olg3QTNpPkOwPVY5Pjl\|PD;hQi=>
Sf9	M4DMdmZ2dmO2aX;uJIF{e2G7			M2W2dmlvcGmkaYTpc44hd2ZiQWTQMYFkfGm4YYTl[EBz\WOxbXLpcoFvfCCqdX3hckBPNXSncn3pcoFtKD[6LVjpd{11[WepZXSgZ{1MUVRiKEW0O{B1dyB7M{WgdoV{cWS3ZYOpM{g3QTRidH:gO\|U{KHKnc3nkeYV{KGSnbHX0bY9vMSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW2Z7IHnud4VkfCClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDwc4x6KCiJbIWsWJlzMSB2OkGgdIhwe3Cqb4L5cIF1cW:wLDDJR\|UxRTVwMkJOwG0v	MlO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7Nki2PVMoRjNyOU[4Olk{RC:jPh?=
BAF3	MVrGeY5kfGmxbjDhd5NigQ>?		MXy3NkBpenN?	NGnWeXJKdmirYnn0bY9vKG:oIGTFUEBnfXOnZDDjMWtKXCCYNUW5S{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxRTBwMECx{txONg>?	NFTKVVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUC0OlI4OSd-M{GwOFYzPzF:L3G+
BAF3	NE\Xe\|lHfW6ldHnvckBie3OjeR?=		M1X2U\|czKGi{cx?=	Ml3LTY5pcWKrdHnvckBw\iCWRVyg[pV{\WRiYz3LTXQhXjV3OVGgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjByNd88UU4>	MofGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyNE[yO\|EoRjNzMES2NlcyRC:jPh?=
GISTT1	M4rXT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2nNXFczKGi{cx?=	NETJXWdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3RVOSClZXzsd{Bp[XKkb4Lpcoch[y2NSWSgOVYxKHSxIEW3PEBl\WyndHnvckBufXSjboSgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD1yLkCyOu69VS5?	NXvxdoJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GwOFYzPzFpPkOxNFQ3OjdzPD;hQi=>
BAF3	M2PBWmZ2dmO2aX;uJIF{e2G7		NXuxZoo5PzJiaILz	MmjmTY5pcWKrdHnvckBw\iCWRVyg[pV{\WRiYz3LTXQhXjV3OVSgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjB\|Od88UU4>	NUPBWoVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GwOFYzPzFpPkOxNFQ3OjdzPD;hQi=>
GIST882	NXj6cYZ1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MmTwO\|IhcHK\|	NIG0XW9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q5QDJiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJGs3PDKHIH31eIFvfCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBES0t6IHHzd4F6NCCJSUWwQVAvODV6zszNMi=>	NGD3RVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUC0OlI4OSd-M{GwOFYzPzF:L3G+
BAF3	MX7GeY5kfGmxbjDhd5NigQ>?		Mn;VO\|IhcHK\|	M4fWWGlvcGmkaYTpc44hd2ZiVFXMJIZ2e2WmIHOtT2lVKEx3N{\QJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:OC5zMUZOwG0v	NXK2T\|ZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GwOFYzPzFpPkOxNFQ3OjdzPD;hQi=>
BAF3	MmDOSpVv[3Srb36gZZN{[Xl?		MlH4O\|IhcHK\|	Mlu2TY5pcWKrdHnvckBw\iCWRVyg[pV{\WRiYz3LTXQhTDh{MFWgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjJ4N988UU4>	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTB2NkK3NUc,OzFyNE[yO\|E9N2F-
BAF3	Mn7ISpVv[3Srb36gZZN{[Xl?		M3nETFczKGi{cx?=	MXvJcohq[mm2aX;uJI9nKHerbHSgeJlx\SCWRVyg[pV{\WRiYz3LTXQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2s5KGG\|c3H5MEBIUTVyPUCuN\|Y1\|ryPLh?=	MoCyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyNE[yO\|EoRjNzMES2NlcyRC:jPh?=
BAF3	M{\YfmZ2dmO2aX;uJIF{e2G7		NFvaTlQ4OiCqcoO=	MUfJcohq[mm2aX;uJI9nKFSHTDDmeZNm\CClLVvJWEBCQDJ7UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0t6IHHzd4F6NCCJSUWwQVAvPDB4zszNMi=>	MlH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyNE[yO\|EoRjNzMES2NlcyRC:jPh?=
BAF3	MmDPSpVv[3Srb36gZZN{[Xl?		MkPRO\|IhcHK\|	NUX4bnhNUW6qaXLpeIlwdiCxZjDUSWwh\nW\|ZXSgZ{1MUVRiREixOmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD1yLkiyN:69VS5?	M2O4OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMES2NlcyLz5\|MUC0OlI4OTxxYU6=
BAF3	M1PldWZ2dmO2aX;uJIF{e2G7		MXK3NkBpenN?	NVnGboQ{UW6qaXLpeIlwdiCxZjDUSWwh\nW\|ZXSgZ{1MUVRiTkiyNmshdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD1zLkK5{txONg>?	MkLTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyNE[yO\|EoRjNzMES2NlcyRC:jPh?=
BAF3	MonSSpVv[3Srb36gZZN{[Xl?		M4[yWFczKGi{cx?=	NV[zRYk3UW6qaXLpeIlwdiCxZjDUSWwh\nW\|ZXSgZ{1MUVRiVk[1OGEwXjV3OVSg[I92[mynIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUzhiYYPzZZktKEeLNUC9NU42P87:TT6=	NHHmWIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUC0OlI4OSd-M{GwOFYzPzF:L3G+
BAF3	MVjGeY5kfGmxbjDhd5NigQ>?		M4TpdVczKGi{cx?=	M4K3NGlvcGmkaYTpc44hd2ZiVFXMJIZ2e2WmIHOtT2lVKFZ4NUTBJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:Oi5\|zszNMi=>	Mlu2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyNE[yO\|EoRjNzMES2NlcyRC:jPh?=
K562	NILhNoRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NYfPeJJMPzJiaILz	NXrITpJySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhemWjbDD0bY1mKGyrdnWtZ4VtdCCrbXHnbY5oKHSnY3jubZF2\SxiSVO1NF0xNjF2zszNMi=>	NXHEO3FXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GwPVc{PzZpPkOxNFk4Ozd4PD;hQi=>
K562	NG\S[GVCeG:ydH;zbZMh[XO\|YYm=	MUOxNEB2VQ>?	NEHIWHU1QCCqcoO=	M1HudGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjcH;weI91cWNiY3XscJMh[XRiMUCgeW0hcW6ldXLheIVlKG[xcjC0PEBpenNiYomgR4F{eGG\|ZT2zM\|chemWjZ3XueE1j[XOnZDDmcJVwemW\|Y3XuZ4Uh[XO\|YYm=	MmnXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzFyOUezO\|YoRjNzMEm3N\|c3RC:jPh?=
K562	NFuzdWlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MlP5OFghcHK\|	M{TiOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQlPSM2FDVCCyb4PpeIl3\SCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;ND6yOu69VS5?	NUX4To9MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GxPFU1OTNpPkOxNVg2PDF\|PD;hQi=>
BAF3	NUfqeVBYTnWwY4Tpc44h[XO\|YYm=		NGr6fWk4OiCqcoO=	MXHJcohq[mm2aX;uJI9nKGNvS1nUJHY2PjCGIH31eIFvfCCrbjDtc5V{\SCEQV[zLJRz[W6\|Zn;ycYVlMSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjByM988UU4>	NGO5Nnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUK1NFY{QCd-M{GyOVA3Ozh:L3G+
BAF3	MYDGeY5kfGmxbjDhd5NigQ>?		NUewVZN{PzJiaILz	Mly3TY5pcWKrdHnvckBw\iClLVvJWEBXPTV7RzDteZRidnRiaX6gcY92e2ViQlHGN{h1emGwc3\vdo1m\CliY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:OC5yMElOwG0v	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3ME[zPEc,OzF{NUC2N\|g9N2F-
BAF3	MkPxSpVv[3Srb36gZZN{[Xl?		NF64fVE4OiCqcoO=	NVX5VHhnUW6qaXLpeIlwdiCxZjDjMWtKXCCYNUW5SEBufXSjboSgbY4hdW:3c3WgRmFHOyi2cnHud4Zwem2nZDmgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGdKPTB;MD6wNe69VS5?	MmrOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUC2N\|goRjNzMkWwOlM5RC:jPh?=
GISTT1	NXj3VJVOTnWwY4Tpc44h[XO\|YYm=		NUPBNXR[PzJiaILz	NFHh[3dKdmirYnn0bY9vKG:oIHOtT2lVKDV4MDD0c{A2PzhiZHXs[ZRqd25ibYX0ZY51KGmwIHj1cYFvKEeLU2TUNUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3ME2wMlAyPc7:TT6=	NV\GSJNZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVA3OzhpPkOxNlUxPjN6PD;hQi=>
BAF3	MWfGeY5kfGmxbjDhd5NigQ>?		MYW3NkBpenN?	MUPJcohq[mm2aX;uJI9nKGNvS1nUJGQ5OjCHIH31eIFvfCCrbjDtc5V{\SCEQV[zLJRz[W6\|Zn;ycYVlMSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjB\|Nd88UU4>	MlTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUC2N\|goRjNzMkWwOlM5RC:jPh?=
GIST882	NEfMXZVHfW6ldHnvckBie3OjeR?=		NXjHdnh[PzJiaILz	M33RUGlvcGmkaYTpc44hd2ZiYz3LTXQhUzZ2MlWgcZV1[W62IHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:OC5yNElOwG0v	NVz4[JRiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVA3OzhpPkOxNlUxPjN6PD;hQi=>
BAF3	M2nrbGZ2dmO2aX;uJIF{e2G7		NX\PUFh[PzJiaILz	M4TkUGlvcGmkaYTpc44hd2ZiYz3LTXQhVDV5NmCgcZV1[W62IHnuJI1wfXOnIFLBSlMpfHKjboPmc5Ju\WRrIHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFQ1u4JIF{e2G7LDDHTVUxRTBwMEi1{txONg>?	NGnSRpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUK1NFY{QCd-M{GyOVA3Ozh:L3G+
BAF3	MkPpSpVv[3Srb36gZZN{[Xl?		MUe3NkBpenN?	NYfUUVNoUW6qaXLpeIlwdiCxZjDjMWtKXCCVN{C5SkBufXSjboSgbY4hdW:3c3WgRmFHOyi2cnHud4Zwem2nZDmgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGdKPTB;MD6xNVXPxE1w	M3XyXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkWwOlM5Lz5\|MUK1NFY{QDxxYU6=
BAF3	NXvBdWJiTnWwY4Tpc44h[XO\|YYm=		M3PicVczKGi{cx?=	Mn7yTY5pcWKrdHnvckBw\iClLVvJWEBFQDF4RTDteZRidnRiaX6gcY92e2ViQlHGN{h1emGwc3\vdo1m\CliY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:OC5zN{VOwG0v	NH6wPHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUK1NFY{QCd-M{GyOVA3Ozh:L3G+
BAF3	NXz1dGJyTnWwY4Tpc44h[XO\|YYm=		NISwVlI4OiCqcoO=	NFLhSmVKdmirYnn0bY9vKG:oIHOtT2lVKER6MkDHJI12fGGwdDDpckBud3W\|ZTDCRWY{MHS{YX7z[o9zdWWmKTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD1yLkOzO:69VS5?	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3ME[zPEc,OzF{NUC2N\|g9N2F-
BAF3	NWfOU4t6TnWwY4Tpc44h[XO\|YYm=		MWi3NkBpenN?	MmnNTY5pcWKrdHnvckBw\iClLVvJWEBqdiCvb4Xz[UBDSUZ\|KITyZY5{\m:{bXXkLUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3ME2wMlM2\|ryPLh?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3ME[zPEc,OzF{NUC2N\|g9N2F-
BAF3	NUTiNJdDTnWwY4Tpc44h[XO\|YYm=		M2DHSVczKGi{cx?=	MYLJcohq[mm2aX;uJI9nKGNvS1nUJGQ5OjC\IH31eIFvfCCrbjDtc5V{\SCEQV[zLJRz[W6\|Zn;ycYVlMSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjR\|Nd88UU4>	M{S3VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkWwOlM5Lz5\|MUK1NFY{QDxxYU6=
BAF3	MVrGeY5kfGmxbjDhd5NigQ>?		M1nacFczKGi{cx?=	NWjobnBuUW6qaXLpeIlwdiCxZjDjMWtKXCCDOEK5VEBufXSjboSgbY4hdW:3c3WgRmFHOyi2cnHud4Zwem2nZDmgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT\|gh[XO\|YYmsJGdKPTB;MD61PO69VS5?	MnziQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUC2N\|goRjNzMkWwOlM5RC:jPh?=
BAF3	MYrGeY5kfGmxbjDhd5NigQ>?		M4fBeFczKGi{cx?=	M3zGbmlvcGmkaYTpc44hd2ZiYz3LTXQhXjZ3NFGvWlU2QURiZH;1ZoxmKG23dHHueEBqdiCvb4Xz[UBDSUZ\|KITyZY5{\m:{bXXkLUBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMQCCjc4PhfUwhT0l3ME2wMlYxQM7:TT6=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3ME[zPEc,OzF{NUC2N\|g9N2F-
BAF3	MmPTSpVv[3Srb36gZZN{[Xl?		NVjKTndYPzJiaILz	NHvZcYRKdmirYnn0bY9vKG:oIHOtT2lVKER6MU\IJI12fGGwdDDpckBud3W\|ZTDCRWY{MHS{YX7z[o9zdWWmKTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD1yLk[1Ne69VS5?	M{fqV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkWwOlM5Lz5\|MUK1NFY{QDxxYU6=
BAF3	NH\yZmdHfW6ldHnvckBie3OjeR?=		MnHBO\|IhcHK\|	MYfJcohq[mm2aX;uJI9nKGNvS1nUJHY2PTmDIH31eIFvfCCrbjDtc5V{\SCEQV[zLJRz[W6\|Zn;ycYVlMSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0xNjlyNd88UU4>	NY\rd\|R3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVA3OzhpPkOxNlUxPjN6PD;hQi=>
BAF3	MoDJSpVv[3Srb36gZZN{[Xl?		NF\he2o4OiCqcoO=	MWLJcohq[mm2aX;uJI9nKGNvS1nUJHY3PTSDIH31eIFvfCCrbjDtc5V{\SCEQV[zLJRz[W6\|Zn;ycYVlMSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF0yNjRzzszNMi=>	MnnvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUC2N\|goRjNzMkWwOlM5RC:jPh?=
BAF3	M1KxSGZ2dmO2aX;uJIF{e2G7		NV;5b5BPPzJiaILz	MnTXTY5pcWKrdHnvckBw\iClLVvJWEBPQDJ{SzDteZRidnRiaX6gcY92e2ViQlHGN{h1emGwc3\vdo1m\CliY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFS{igZZN{[XluIFfJOVA:OS52N988UU4>	MnvSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUC2N\|goRjNzMkWwOlM5RC:jPh?=
BAF3	MnTESpVv[3Srb36gZZN{[Xl?		MmrXO\|IhcHK\|	NE\mOlBKdmirYnn0bY9vKG:oIHOtT2lVKFR4N{DFJI12fGGwdDDpckBud3W\|ZTDCRWY{MHS{YX7z[o9zdWWmKTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeTygS2k2OD12LkC4{txONg>?	NWqxSmViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVA3OzhpPkOxNlUxPjN6PD;hQi=>
BAF3	M1T6cmZ2dmO2aX;uJIF{e2G7		MkTaO\|IhcHK\|	MVnJcohq[mm2aX;uJI9nKGNvS1nUJHk5OjOGIH31eIFvfCCrbjDtc5V{\SCEQV[zLJRz[W6\|Zn;ycYVlMSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONODDhd5NigSxiR1m1NF02Njh5zszNMi=>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3ME[zPEc,OzF{NUC2N\|g9N2F-
GISTT1	NYi5ZY5DSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGnOfms4OiCqcoO=	M3LhcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWHQyKGOnbHzzJIhiemKxcnnu[{BkNUuLVDC1OlAhfG9iNUe4JIRmdGW2aX;uJI12fGGwdDDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ1PLPEBie3OjeR?=	NUDvUIpmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVA3OzhpPkOxNlUxPjN6PD;hQi=>
EOL-1	Mo\YR5l1d3SxeHnjbZR6KGG\|c3H5		Mn2xO\|IhcHK\|	NXXrU3RbS3m2b4TvfIlkcXS7IHHnZYlve3RiRlnQNWwyNVCGR1\SRUBxd3OrdHn2[UBpfW2jbjDFU2wuOSClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhemW\|YYr1dolvKGS7ZT3iZZNm\CCobIXvdoV{[2WwY3WgZY5idHm\|aYOsJGdKPTB:MD6wNFA2\|ryPLh?=	NXfHNWRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NVQxOTlpPkOxOVE1ODF7PD;hQi=>
K562	MkDRR5l1d3SxeHnjbZR6KGG\|c3H5		NFnJSlc4OiCqcoO=	MmHwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhemW\|YYr1dolvKGS7ZT3iZZNm\CCobIXvdoV{[2WwY3WgZY5idHm\|aYOsJGdKPTB;MD63N:69VS5?	NW[xTZFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NVQxOTlpPkOxOVE1ODF7PD;hQi=>
CEM	M1iwW2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MVi3NkBpenN?	MljwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2VOKGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBz\XOjeoXybY4h\HmnLXLhd4VlKG[udX;y[ZNk\W6lZTDhcoFtgXOrczygS2k2OD1\|NT64NFnPxE1w	NUL6[oVDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NVQxOTlpPkOxOVE1ODF7PD;hQi=>
Ba/F3	MYDGeY5kfGmxbjDhd5NigQ>?		NIrLNJc4OiCqcoO=	M3qxe2lvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFLDVk9C[mxiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE1OzkQvF2u	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZ7OU[xNkc,OzF4OUm2NVI9N2F-
Ba/F3	M1vVNGZ2dmO2aX;uJIF{e2G7		NHrlNmM4OiCqcoO=	M4XQN2lvcGmkaYTpc44hd2ZiQlPSM2FjdCCSMkOwJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX70JINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjJzNd88UU4>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZ7OU[xNkc,OzF4OUm2NVI9N2F-
Ba/F3	MUTGeY5kfGmxbjDhd5NigQ>?		NULtT4VHPzJiaILz	NWK0ZldIUW6qaXLpeIlwdiCxZjDCR3IwSWKuIGCxPVAhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5\|NEW1{txONg>?	M17WWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNkm5OlEzLz5\|MU[5PVYyOjxxYU6=
Ba/F3	MnnKSpVv[3Srb36gZZN{[Xl?		M4PidFczKGi{cx?=	M3XWR2lvcGmkaYTpc44hd2ZiQlPSM2FjdCCIM{G3TUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDseY1qdmW\|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjN4NN88UU4>	NI\xW2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[5PVYyOid-M{G2PVk3OTJ:L3G+
Ba/F3	Mn;QSpVv[3Srb36gZZN{[Xl?		M17vOVczKGi{cx?=	MV3Jcohq[mm2aX;uJI9nKEKFUj;BZowhXjJ7OVygcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIIDyc4xq\mW{YYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE41ODV\|zszNMi=>	MmTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF4OUm2NVIoRjNzNkm5OlEzRC:jPh?=
Ba/F3	M1nSemZ2dmO2aX;uJIF{e2G7		NXm5Vod{PzJiaILz	M3PJc2lvcGmkaYTpc44hd2ZiQlPSM2FjdCCTMkWyTEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDseY1qdmW\|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjR6NkZOwG0v	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTZ7OU[xNkc,OzF4OUm2NVI9N2F-
Ba/F3	M3fqNWZ2dmO2aX;uJIF{e2G7		MYC3NkBpenN?	NUXoSW9RUW6qaXLpeIlwdiCxZjDCR3IwSWKuIF[zNVdNKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKjL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwN{G2N:69VS5?	MoTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF4OUm2NVIoRjNzNkm5OlEzRC:jPh?=
Ba/F3	MnizSpVv[3Srb36gZZN{[Xl?		NXzTT4FDPzJiaILz	NV;BSG81UW6qaXLpeIlwdiCxZjDCR3IwSWKuIF2zOVFVKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKjL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwN{m5N:69VS5?	M2jkUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNkm5OlEzLz5\|MU[5PVYyOjxxYU6=
Ba/F3	MlzRSpVv[3Srb36gZZN{[Xl?		MnLNO\|IhcHK\|	NILrcWNKdmirYnn0bY9vKG:oIFLDVk9C[mxiSEO5OnAhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJBzd2yrZnXyZZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55MEdOwG0v	MmjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF4OUm2NVIoRjNzNkm5OlEzRC:jPh?=
Ba/F3	MlXGSpVv[3Srb36gZZN{[Xl?		M1nPPFczKGi{cx?=	M3rndGlvcGmkaYTpc44hd2ZiQlPSM2FjdCCHMkW1T{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDseY1qdmW\|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{NjJ3N988UU4>	MlvGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF4OUm2NVIoRjNzNkm5OlEzRC:jPh?=
Ba/F3	M2XwTmZ2dmO2aX;uJIF{e2G7		NUfNRZVDPzJiaILz	NVXKfVFbUW6qaXLpeIlwdiCxZjDCR3IwSWKuIGmyOVNHKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKjL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRThwN{e4{txONg>?	NEHCSpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MU[5PVYyOid-M{G2PVk3OTJ:L3G+
GISTT1	M{XEWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NGjldlE4OiCqcoO=	NUDhV2hNSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVXDFiY3XscJMhcGG{Yn;ybY5oKGindHXyc5p6\2:3czDk[YxmfGmxbjDteZRifGmxbjDheEBENWurdDDlfI9vKDFzIHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmeiB7NjDBVZVmd3W\|IF;u[UBUd2y3dHnvckBE\WyuIGDyc4xq\mW{YYTpc44h[XO\|YYmsJGdKPTB;MD6wOO69VS5?	M1PifVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{KxOVc5Lz5\|MUeyNVU4QDxxYU6=
Sf9	NIHlU5JHfW6ldHnvckBie3OjeR?=		NVq4W3VpOTVyIH3pcpM>	MUPJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IF6teIVzdWmwYXygOpguUGm\|LYTh[4dm\CClLVvJWEApPTR5IITvJFk{PSC{ZYPp[JVmeylxKE[5OEB1dyB5NUOgdoV{cWS3ZYOg[IVt\XSrb36pJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKGKjY4Xsc5ZqenW\|IHnu[oVkfGWmIGPmPUBqdnOnY4SgZ4VtdHNidYPpcocheG:ueTCoS4x2NFS7cjmgOFoyKGG\|IIP1ZpN1emG2ZTDt[YF{fXKnZDDh[pRmeiBzNUCgcYlveyCrbjDwdoV{\W6lZTDv[kAtKEmFNUC9NE4xPTQQvF2u	NIjudlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUeyNVU4QCd-M{G3NlE2Pzh:L3G+
Sf9	NXyyPZdRTnWwY4Tpc44h[XO\|YYm=		MV[0JIhzew>?	NECwSmFKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDy[YNwdWKrbnHueEBIW1RvdHHn[4VlKE[OVEOgLHk2PjdidH:gV\|k6OyC{ZYPp[JVmeyliKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW2Z7IHnud4VkfCClZXzsd{B2e2mwZzDI[ZIzKHCncITp[IUh[XNic4Xid5Rz[XSnIH3lZZN2emWmIHHmeIVzKDRiaILzJIlvKHC{ZYPlcoNmKG:oIFHUVEBjgSCNaX7hd4UuT2yxIGDseZMhemWjZ3XueE1j[XOnZDDseY1qdmVuIFnDOVA:OC5zM{JOwG0v	M3jBd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{KxOVc5Lz5\|MUeyNVU4QDxxYU6=
GIST882	MmTyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mn\iNVQ1KGi{cx?=	M2m3RWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{Bp[XKkb4Lpcoch[y2NSWSg[ZhwdiBzMzDoc41wgnmpb4XzJJBzcW2jcomgT\|Y1OkVibYX0ZY51KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgNVQ1KGi{czDifUBu\XSqeXzlcoUh[my3ZTDzeIFqdmmwZzDiZZNm\CCjc4PhfUwhT0l3ME2wMlE6Pc7:TT6=	NF71RXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MUeyNVU4QCd-M{G3NlE2Pzh:L3G+
GIST430	MmHmRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3vWb\|EzOCCqcoO=	NH2yXnVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q1OzBiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJIV5d25iMUGgdJJqdWG{eTDpck1nemGvZTDWOVYxNUx3N{[g[IVt\XSrb36gcZV1[W62IHHu[EBmgG:wIEGzJIhmfGW{b4r5[492eyC\|ZXPvcoRienlibXnzd4Vve2ViVk[1OGEhdXW2YX70JIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMUKwJIhzeyCkeTDt[ZRpgWynbnWgZox2\SC\|dHHpcolv\yBuIFfJOVA:OC54MkZOwG0v	NYnqT2RuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G3NlE2PzhpPkOxO\|IyPTd6PD;hQi=>
GIST48	NULSOHluSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MmT6NVIxKGi{cx?=	NEPCeWlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q1QCClZXzsd{Bp[XKkb4Lpcoch[y2NSWSg[ZhwdiBzMTDoc41wgnmpb4XzJJBzcW2jcomgcYl{e2Wwc3WgWlU3OERibYX0ZY51KGGwZDDlfI9vKDF5IHjleIVzd3q7Z3;1d{B{\WOxbnThdpkhTDh{MFGgcZV1[W62IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhOTJyIHjyd{BjgSCvZYTofYxmdmViYnz1[UB{fGGrbnnu[{Bj[XOnZDDhd5NigSxiR1m1NF0xNjl{Od88UU4>	MmXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5MkG1O\|goRjNzN{KxOVc5RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5 ; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho STAT3, anti-STAT3, anti-phospho STAT5 or anti-STAT5 Abs. p-ZAP70 / ZAP70 / p-LAT / LAT ; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-activated cells were used as controls (NA). p-STAT3 / STAT3 / p-STAT5 / STAT5 ; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho STAT3, anti-STAT3, anti-phospho STAT5 or anti-STAT5 Abs. p-ZAP70 / ZAP70 / p-LAT / LAT ; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-activated cells were used as controls (NA).	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin ; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at invadopodia. RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry. Cortactin / F-actin ; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at invadopodia.	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone. Abbreviations: IM, imatinib; SD, standard deviation.	28435223

In vivo

Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. ^[5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. ^[6]

Protocol

Kinase Assay:

^[1]

- Collapse

PDGF receptor kinase activity:

PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl₂). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-³³P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.

Cell Research:

^[3]

- Collapse

Cell lines: BON-1 cells and NCI-H727 cells
Concentrations: ~100 μM
Incubation Time: 48 hours
Method:
BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively.

(Only for Reference)

References

- Collapse

Solubility (25°C)

In vitro	DMSO	33 mg/mL (66.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 2% DMSO+30% PEG 300+2% Tween 80+ddH2O For best results, use promptly after mixing.	2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Imatinib (STI571) SDF

Molecular Weight	493.6
Formula	C₂₉H₃₁N₇O
CAS No.	152459-95-5
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Gleevec, Glivec, CGP057148B
Smiles	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04794088	Recruiting	Drug: Imatinib Mesylate intravenous solution\|Drug: Placebo	ARDS\|Acute Respiratory Distress Syndrome\|Covid19\|Endothelial Dysfunction\|Pulmonary Edema	Dr. Jurjan Aman\|Simbec Orion\|Exvastat Ltd.\|KABS laboratories\|VU University Medical Center	March 14 2021	Phase 2
NCT04326933	Not yet recruiting	Drug: Tyrosine kinase Inhibitors (Imatinib & Nilotinib)	Patients Diagnosed as Chronic Meyloid Leukemia	Assiut University	October 20 2020	--
NCT04357613	Not yet recruiting	Drug: Experimental drug	SARS Virus	Versailles Hospital	September 1 2020	Phase 2
NCT04422678	Not yet recruiting	Drug: Imatinib Mesylate\|Drug: Standard of Care	COVID-19	Alexandria University\|Science Technology & Innovation Funding Authority (STIFA) Egypt	June 2020	Phase 3
NCT04097093	Withdrawn	Other: No intervention	GIST	European Organisation for Research and Treatment of Cancer - EORTC	June 1 2020	--
NCT03997903	Recruiting	Drug: Imatinib Mesylate	Sickle Cell Disease	Indiana University\|Purdue University\|Children''s Hospital Medical Center Cincinnati	February 26 2020	Early Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
Could you please advise whether it is a clear solution for compound dissolved in vehicle 2% DMSO+30% PEG 300+2% Tween 80+ddH2O?
Answer:
For S2475 Imatinib (STI571), it is soluble in 2% DMSO+30% PEG 300+2% Tween 80+ddH2O at 2mg/ml. When making the solution, please dissolve the compound in DMSO clearly first. If it dissolves not readily, please sonicate and warm it in water bath at 45-50C. Then add PEG and Tween. After they mixed well, dilute with water.
Question 2:
What is the difference between S2475 (Imatinib) and S1026 (Imatinib Mesylate)? Are they water soluble?
Answer:
S2475 is free base of Imatinib while S1026 is a solt form of Imatinib. They have exactly the same biological activity but different solubility. S1026 can be dissolved in water, but S2475 is not soluble in water. S2475 can be dissolved in DMSO at up to 3mg/ml.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Selective PDGFR Inhibitor

Sunitinib Malate : PDGFRβ-selective, IC50=2 nM.
Most Potent PDGFR Inhibitors

Axitinib : PDGFRβ, IC50=1.6 nM.
Most Potent PDGFR Inhibitors

Ponatinib (AP24534) : PDGFRα, IC50=1.1 nM.
FDA-approved PDGFR Inhibitor

Imatinib Mesylate (STI571) : Approved by FDA for CML, GISTs and a number of other malignancies.
Newest PDGFR Inhibitor

Tyrphostin AG 1296 : Inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.

Related PDGFR Products

Sunitinib (SU11248) ^New

Sunitinib (SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
Erlotinib (OSI-774) ^New

Erlotinib (OSI-774, CP358774, NSC 718781, Tarceva) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib induces autophagy.
Bemcentinib (R428) ^New

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
Sunitinib (SU11248) malate

Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
CP-673451

CP-673451 is a selective inhibitor of PDGFRα/β with IC50 of 10 nM/1 nM in cell-free assays, exhibits >450-fold selectivity over other angiogenic receptors, has antiangiogenic and antitumor activity.
Crenolanib (CP-868596)

Crenolanib (CP-868596, ARO 002) is a potent and selective inhibitor of PDGFRα/β with K_d of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
Tyrphostin AG 1296

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. Tyrphostin AG1296 induces dramatic apoptosis in A375R cells.
Sennoside B

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Gefitinib (ZD1839)

Gefitinib (ZD-1839, Iressa) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib promotes autophagy and apoptosis of lung cancer cells via blockade of the PI3K/AKT/mTOR pathway.

Features:A potent EGFR tyrosine kinase inhibitor.

Choose Your Country or Region

By Signaling Pathways

By product type

Imatinib (STI571)