Imatinib (STI571)

Name: Imatinib (STI571)
Brand: Selleck Chemicals
SKU: S2475
Rating: 5 (213 reviews)

For research use only.

Catalog No.S2475 Synonyms: Gleevec, Glivec, CGP057148B

213 publications

CAS No. 152459-95-5

Imatinib (STI571, CGP057148B, Gleevec) is a multi-target inhibitor of tyrosine kinase with inhibition for v-Abl, c-Kit and PDGFR, IC50 values are 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib (STI571) induces autophagy.

Selleck's Imatinib (STI571) has been cited by 213 publications

Science, 2020, 370(6513)eabc2754

PubMed: 33004676 ( click the link to review the publication )

Cancer Cell, 2019, 36(4):431-443

PubMed: 31543464 ( click the link to review the publication )

Cancer Cell, 2018, 34(2):271-285.e7

PubMed: 30107177 ( click the link to review the publication )

Cancer Cell, 2018, 34(4):626-642

PubMed: 30300583 ( click the link to review the publication )

Cancer Cell, 2014, 26(6):840-50

PubMed: 25490448 ( click the link to review the publication )

Cell Stem Cell, 2012, 10(2):210-7

PubMed: 22305570 ( click the link to review the publication )

Nat Commun, 2021, 12(1):51

PubMed: 33397955 ( click the link to review the publication )

Cell Death Dis, 2021, 12(4):367

PubMed: 33824300 ( click the link to review the publication )

J Clin Endocrinol Metab, 2021, dgab020

PubMed: 33524147 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab011

PubMed: 33438013 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab014

PubMed: 33450762 ( click the link to review the publication )

Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

PubMed: 33403501 ( click the link to review the publication )

Blood, 2020, 8 pii: blood

PubMed: 32270193 ( click the link to review the publication )

Cell Host Microbe, 2020, 11;27(3):476-485 e7

PubMed: 32101706 ( click the link to review the publication )

Nat Commun, 2020, 11(1):5060

PubMed: 33033246 ( click the link to review the publication )

Sci Adv, 2020, 6(33):eaaz8850

PubMed: 32851160 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2020, 117(8):4300-4309

PubMed: 32047031 ( click the link to review the publication )

Clin Cancer Res, 2020, 21;clincanres31422019

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Genome Med, 2020, 18;12(1):17

PubMed: 32070411 ( click the link to review the publication )

Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

Cell Rep, 2020, 33(1):108221

PubMed: 33027668 ( click the link to review the publication )

Cell Rep, 2020, 24;30(12):3951-3963 e4

PubMed: 32209458 ( click the link to review the publication )

J Hematol Oncol, 2020, 13(1):80

PubMed: 32552902 ( click the link to review the publication )

Antioxid Redox Signal, 2020, 32(1):35-59

PubMed: 31656084 ( click the link to review the publication )
Cancer Lett, 2020, 469:195-206

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Cancers (Basel), 2020, 25;12(5)

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Cancers (Basel), 2020, 13;12(2) pii: E436

PubMed: 32069833 ( click the link to review the publication )

PLoS Pathog, 2020, 16(8):e1008823

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Br J Cancer, 2020, 10.1038/s41416-020-0952-1

PubMed: 32572172 ( click the link to review the publication )

FASEB J, 2020, 34(3):3773-3791

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Mol Cell Proteomics, 2020, 10.1074/mcp.RA119.001504

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Aging (Albany NY), 2020, 12(17):17662-17680

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Front Bioeng Biotechnol, 2020, 20;8:482

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Am J Cancer Res, 2020, 10(12):4251-4265

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Front Oncol, 2020, 12;10:696

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J Cell Sci, 2020, 11 pii: jcs

PubMed: 32393599 ( click the link to review the publication )

Sci Rep, 2020, 10(1):11269

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Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Am J Physiol Cell Physiol, 2020, 10.1152/ajpcell.00290.2020

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Front Physiol, 2020, 11:555006

PubMed: 33329018 ( click the link to review the publication )

Oncol Rep, 2020, 44(5):2152-2164

PubMed: 32901871 ( click the link to review the publication )

J Pharm Biomed Anal, 2020, 195:113864

PubMed: 33387839 ( click the link to review the publication )

J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

PubMed: 33165739 ( click the link to review the publication )

Micromachines (Basel), 2020, 11(2)

PubMed: 32085455 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Biochim Biophys Acta Gen Subj, 2020, 1864(4):129507

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Commun Biol, 2020, 3(1):18

PubMed: 31925328 ( click the link to review the publication )
bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )

Front Aging Neurosci, 2020, 12:7

PubMed: 32116646 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 529(3):699-706

PubMed: 32736695 ( click the link to review the publication )

Ann N Y Acad Sci, 2020, 1467(1):77-93

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J Pers Med, 2020, 10(4)E234

PubMed: 33212994 ( click the link to review the publication )

Cancer Cell, 2020, 38(6):872-890.e6

PubMed: 33217342 ( click the link to review the publication )

Hemasphere, 2020, 4(6):e497

PubMed: 33196013 ( click the link to review the publication )

Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

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J Clin Invest, 2019, 129(3):1167-1179

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Nat Commun, 2019, 10(1):2204

PubMed: 31101827 ( click the link to review the publication )

Sci Adv, 2019, 5(2):eaau7130

PubMed: 30775435 ( click the link to review the publication )

Dev Cell, 2019, 51(2):236-254

PubMed: 31543445 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2019.215939

PubMed: 31289206 ( click the link to review the publication )

Cell Rep, 2019, 28(9):2331-2344

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J Control Release, 2019, 310:141-154

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Thyroid, 2019, 29(5):674-682

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J Exp Clin Cancer Res, 2019, 18;38(1):85

PubMed: 30777101 ( click the link to review the publication )

Cancer Discov, 2019, 9(6):756-777

PubMed: 30862724 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(6):1137-1148

PubMed: 30926633 ( click the link to review the publication )

Mol Cancer Ther, 2019, 18(11):1985-1996

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Hum Reprod, 2019, 34(3):506-518

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J Cell Mol Med, 2019, 23(12):8314-8327

PubMed: 31576676 ( click the link to review the publication )

Neuropharmacology, 2019, 149:13-26

PubMed: 30731136 ( click the link to review the publication )

Cancer Manag Res, 2019, 11:5197-5208

PubMed: 31239774 ( click the link to review the publication )
Eur J Hum Genet, 2019, 27(4):574-581

PubMed: 30573803 ( click the link to review the publication )

Prostate, 2019, 79(3):259-264

PubMed: 30370673 ( click the link to review the publication )

Molecules, 2019, 24(3)

PubMed: 30754629 ( click the link to review the publication )

Molecules, 2019, 25(1)

PubMed: 31877920 ( click the link to review the publication )

Med Oncol, 2019, 36(3):30

PubMed: 30796703 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 512(4):871-876

PubMed: 30929921 ( click the link to review the publication )

Leuk Lymphoma, 2019, 60(1):189-199

PubMed: 29741440 ( click the link to review the publication )

Leuk Res, 2019, 78:12-20

PubMed: 30660961 ( click the link to review the publication )

Mol Med Rep, 2019, 20(4):3233-3239

PubMed: 31432109 ( click the link to review the publication )

Anticancer Res, 2019, 39(7):3785-3793

PubMed: 31262905 ( click the link to review the publication )

Res Vet Sci, 2019, 124:1-9

PubMed: 30716585 ( click the link to review the publication )

J Exp Med, 2019, 216(3):688-703

PubMed: 30710055 ( click the link to review the publication )

Cancer Invest, 2019, 37(6):242-252

PubMed: 31296070 ( click the link to review the publication )

Nat Biomed Eng, 2018, 2(8):578-588

PubMed: 31015631 ( click the link to review the publication )

Acta Neuropathol, 2018, 135(5):779-798

PubMed: 29305721 ( click the link to review the publication )

Nat Commun, 2018, 9(1):2377

PubMed: 29915352 ( click the link to review the publication )

Nat Commun, 2018, 9(1):4583

PubMed: 30389923 ( click the link to review the publication )

Elife, 2018, 7e36656

PubMed: 29901437 ( click the link to review the publication )

Int J Cancer, 2018, 142(1):156-164

PubMed: 28906000 ( click the link to review the publication )

Oncogene, 2018, 37(21):2837-2849

PubMed: 29511345 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 25;37(1):170

PubMed: 30045750 ( click the link to review the publication )

Cell Death Discov, 2018, 4:48

PubMed: 29707241 ( click the link to review the publication )

Front Immunol, 2018,

PubMed: 30127787 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(12):2551-2563

PubMed: 30217967 ( click the link to review the publication )
Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )

Neoplasia, 2018, 20(8):857-870

PubMed: 30025229 ( click the link to review the publication )

Cancer Sci, 2018, 109(9):2792-2800

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Mol Cancer Res, 2018, 16(6):935-946

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J Cell Physiol, 2018, 233(9):7467-7479

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Cancer Sci, 2018, 109(11):3591-3601

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Biochem Pharmacol, 2018, 156:248-264

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Am J Physiol Lung Cell Mol Physiol, 2018, 315(6):L965-L976

PubMed: 30211651 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2018, 58(2):181-193

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Biomed Pharmacother, 2018, 106:403-410

PubMed: 29966986 ( click the link to review the publication )

Int J Oncol, 2018, 52(6):2061-2068

PubMed: 29620253 ( click the link to review the publication )

Molecules, 2018, 23(10)

PubMed: 30326595 ( click the link to review the publication )

Oncol Rep, 2018, 40(2):902-908

PubMed: 29845257 ( click the link to review the publication )

PLoS One, 2018, 13(2):e0191890

PubMed: 29389967 ( click the link to review the publication )

BMC Pharmacol Toxicol, 2018, 19(1):80

PubMed: 30514402 ( click the link to review the publication )

Int J Clin Exp Pathol, 2018, 11(1):179-188

PubMed: 31938099 ( click the link to review the publication )

Hemasphere, 2018, 2(3):e41

PubMed: 31723769 ( click the link to review the publication )

Oncotarget, 2018, 9(100):37352-37366

PubMed: 30647837 ( click the link to review the publication )

Sci Rep, 2018, 8(1):14896

PubMed: 30291293 ( click the link to review the publication )

Nat Commun, 2017, 8(1):1420

PubMed: 29127277 ( click the link to review the publication )

Leukemia, 2017, 31(11):2376-2387

PubMed: 28366933 ( click the link to review the publication )

Cancer Res, 2017, 77(20):5554-5563

PubMed: 28923853 ( click the link to review the publication )

Cancer Res, 2017, 77(5):1142-1154

PubMed: 27899378 ( click the link to review the publication )

Cell Rep, 2017,

PubMed: 28564604 ( click the link to review the publication )
Cell Rep, 2017, 20(12):2775-2783

PubMed: 28930674 ( click the link to review the publication )

Elife, 2017, 6

PubMed: 28199182 ( click the link to review the publication )

Oncogene, 2017, 36(15):2066-2073

PubMed: 27694901 ( click the link to review the publication )

Cell Death Dis, 2017, 8(10):e3117

PubMed: 29022905 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Cell Chem Biol, 2017, 24(7):858-869

PubMed: 28669525 ( click the link to review the publication )

Cell Chem Biol, 2017, 24(10):1250-1258.e4

PubMed: 28919041 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(9):1729-1738

PubMed: 28619758 ( click the link to review the publication )

Mol Pharm, 2017, 14(10):3558-3567

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Sci Rep, 2017,

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J Biol Chem, 2017, 292(9):3683-3691

PubMed: 28087699 ( click the link to review the publication )

J Biol Chem, 2017,

PubMed: 27903634 ( click the link to review the publication )

Invest New Drugs, 2017, 35(4):427-435

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BMC Cancer, 2017,

PubMed: 28806950 ( click the link to review the publication )

Bioconjug Chem, 2017, 28(10):2608-2619

PubMed: 28903003 ( click the link to review the publication )

Molecules, 2017, 22(12)

PubMed: 29206199 ( click the link to review the publication )

Drug Des Devel Ther, 2017, 11:1115-1126

PubMed: 28435223 ( click the link to review the publication )

Dig Dis Sci, 2017, 62(5):1193-1203

PubMed: 28315973 ( click the link to review the publication )

PLoS One, 2017, 12(7):e0180401

PubMed: 28753604 ( click the link to review the publication )

PLoS One, 2017, 12(5):e0177871

PubMed: 28520795 ( click the link to review the publication )

Leuk Lymphoma, 2017, 58(6):1455-1467

PubMed: 27733071 ( click the link to review the publication )

SLAS Discov, 2017, 22(7):915-922

PubMed: 28346107 ( click the link to review the publication )

Oncotarget, 2017, 8(14):23213-23227

PubMed: 28390196 ( click the link to review the publication )

Oncotarget, 2017, 8(27):43662-43677

PubMed: 28599273 ( click the link to review the publication )
Blood Adv, 2017, 1(20):1635-1644

PubMed: 29296810 ( click the link to review the publication )

Leuk Lymphoma, 2017, 58(8):1903-1913

PubMed: 27931141 ( click the link to review the publication )

Oncotarget, 2017, 8(17):28906-28921

PubMed: 28423649 ( click the link to review the publication )

Oncotarget, 2017, 8(23):37594-37604

PubMed: 28410239 ( click the link to review the publication )

Blood, 2016, 28;127(17):2131-43

PubMed: 26864341 ( click the link to review the publication )

J Clin Invest, 2016, 126(10):3961-3980

PubMed: 27643437 ( click the link to review the publication )

EMBO Mol Med, 2016, 1;8(2):105-16

PubMed: 26758680 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2302-2313

PubMed: 27474148 ( click the link to review the publication )

Traffic, 2016, 17(4):351-68

PubMed: 26650385 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2016, 311(2):L364-74

PubMed: 27261451 ( click the link to review the publication )

Cell Signal, 2016, 28(10):1489-501

PubMed: 27373199 ( click the link to review the publication )

Oncol Rep, 2016, 36(6):3643-3650

PubMed: 27748929 ( click the link to review the publication )

Pharmacol Rep, 2016, 68(1):1-6

PubMed: 26721343 ( click the link to review the publication )

Ups J Med Sci, 2016, 121(2):140-5

PubMed: 26953716 ( click the link to review the publication )

Cell Biochem Biophys, 2016, 74(2):277-83

PubMed: 26912059 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45916-45925

PubMed: 27322141 ( click the link to review the publication )

Oncotarget, 2016, 7(34):54583-54595

PubMed: 27409346 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26709-23

PubMed: 27050374 ( click the link to review the publication )

Genes Cancer, 2016, 7(9-10):292-300

PubMed: 28050230 ( click the link to review the publication )

Nat Commun, 2015, 6:7002

PubMed: 25926053 ( click the link to review the publication )

Nat Commun, 2015, 6:8481

PubMed: 26412466 ( click the link to review the publication )

Oncogene, 2015, 10.1038/onc.2015.111

PubMed: 25893286 ( click the link to review the publication )

J Med Chem, 2015, 58(23):9228-37

PubMed: 26562217 ( click the link to review the publication )

J Urol, 2015, 194(6):1797-805

PubMed: 26055827 ( click the link to review the publication )
Cancer Sci, 2015, 106(2):160-70

PubMed: 25458015 ( click the link to review the publication )

J Cell Sci, 2015, 128(2):251-65

PubMed: ( click the link to review the publication )

Exp Cell Res, 2015, 332(1):1-10

PubMed: 25637219 ( click the link to review the publication )

Leuk Lymphoma, 2015, 56(6):1813-20

PubMed: 25146433 ( click the link to review the publication )

Leuk Res, 2015, 39(3):355-60

PubMed: 25575688 ( click the link to review the publication )

Leuk Res, 2015, 10.1016/j.leukres.2015.08.007

PubMed: 26346348 ( click the link to review the publication )

Oncol Lett, 2015, 10(5):2835-2841

PubMed: 26722250 ( click the link to review the publication )

Sci Rep, 2015, 5:9775

PubMed: 25965812 ( click the link to review the publication )

Blood, 2014, 123(21):3296-304

PubMed: 24723681 ( click the link to review the publication )

Leukemia, 2014, 28(4):977-9

PubMed: 24186003 ( click the link to review the publication )

Elife, 2014, 3:e02523

PubMed: 24844246 ( click the link to review the publication )

Sci Signal, 2014, 7(322):ra38

PubMed: 24757178 ( click the link to review the publication )

Stem Cells, 2014, 32(9):2324-37

PubMed: 24806995 ( click the link to review the publication )

Mol Cancer Ther, 2014, 13(6):1664-72

PubMed: 24723451 ( click the link to review the publication )

Mol Oncol, 2014, 8(5):968-81

PubMed: 24747080 ( click the link to review the publication )

Drug Metab Dispos, 2014, 42(3):318-22

PubMed: 24335466 ( click the link to review the publication )

J Alzheimers Dis, 2014, 41(3):729-37

PubMed: 24662099 ( click the link to review the publication )

Thrombo Res, 2014, 135(1):155-60

PubMed: 25527332 ( click the link to review the publication )

PLoS One, 2014, 9(1):e84900

PubMed: 24454763 ( click the link to review the publication )

PLoS One, 2014, 9(3):e91782

PubMed: 24626299 ( click the link to review the publication )

Biochem Biophys Res Commun, 2014, 455(3-4):256-61

PubMed: 25449280 ( click the link to review the publication )

Leuk Lymphoma, 2014, 22:1-8

PubMed: 25146433 ( click the link to review the publication )

Biochem Biophy Res Co, 2014, 10.1016/j.bbrc.2014.11.002

PubMed: ( click the link to review the publication )

BMC Vet Res, 2014, 10:105

PubMed: 24885200 ( click the link to review the publication )
Mol Med Rep, 2014, 10(3):1519-24

PubMed: 24939418 ( click the link to review the publication )

Biol Pharm Bull, 2014, 37(8):1330-5

PubMed: 25087954 ( click the link to review the publication )

Harbin Medical University, 2014, Wang GY

PubMed: ( click the link to review the publication )

Oncoscience, 2014, 1(1):57-68

PubMed: 25593988 ( click the link to review the publication )

Oncotarget, 2014, 5(7):1926-41

PubMed: 24732172 ( click the link to review the publication )

Clin Cancer Res, 2013, 19(24):6935-42

PubMed: 24132921 ( click the link to review the publication )

PLoS Biol, 2013, 11(3):e1001515

PubMed: 23526884 ( click the link to review the publication )

Clin Cancer Res, 2013, 19(9):2381-92

PubMed: 23532890 ( click the link to review the publication )

Cancer Discov, 2013, 3(5):520-33

PubMed: 23365119 ( click the link to review the publication )

Apoptosis, 2013, 18(11):1437-1446

PubMed: 23851982 ( click the link to review the publication )

Apoptosis, 2013, 18(9):1060-70

PubMed: 23613107 ( click the link to review the publication )

Transl Oncol, 2013, 6(2):187-96

PubMed: 23544171 ( click the link to review the publication )

Int J Mol Med, 2013, 31(2):453-8

PubMed: 23233089 ( click the link to review the publication )

Leuk Lymphoma, 2013, 54(2):342-52

PubMed: 22762548 ( click the link to review the publication )

Biomed Chromatogr, 2013, 27(4):502-8

PubMed: 23034891 ( click the link to review the publication )

J Virol, 2012, 86(18):10112-22

PubMed: 22787216 ( click the link to review the publication )

Leuk Res, 2012, 37(2):183-9

PubMed: 23218026 ( click the link to review the publication )

Clin Pharmacol Ther, 2011, 90(1):157-63

PubMed: 21633340 ( click the link to review the publication )

Cell Death Dis, 2011, 2:e170

PubMed: 21654828 ( click the link to review the publication )

FASEB J, 2011, 25(10):3661-73

PubMed: 21705667 ( click the link to review the publication )

PLoS One, 2010, 5(11):e14143

PubMed: 21152443 ( click the link to review the publication )

Purity & Quality Control

Choose Selective PDGFR Inhibitors

Biological Activity

Description

Targets

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. ^[1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. ^[2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. ^[3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
LAMA-84	M2fycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NHG2UXZKSzVyPUCuNFc{ODRizszN	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EM-2	NHjCVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NXTWPXdUUUN3ME2wMlA5QDhizszN	NHuwcJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MEG-01	NFH1OpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MUPJR\|UxRTBwMEi5NlEh\|ryP	NFnnUos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
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HEK293	MonpSpVv[3Srb36gZZN{[Xl?			MWnJcohq[mm2aX;uJI9nKGG3dH;wbI9{eGixconsZZRqd25ib3[gSGRTOSCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KGK7IFXMTXNCNCCLQ{WwQVAvODR\|zszNMi=>	MknMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
A31	MoP2SpVv[3Srb36gZZN{[Xl?			Mo\xTY5pcWKrdHnvckBw\iCqdX3hckBRTEeIUnHsdIhiKGG3dH;wbI9{eGixconsZZRqd25iaX6gbJVu[W5iQUOxJINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwMEey{txONg>?	NH7xbpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
A31	NHTIXpRHfW6ldHnvckBie3OjeR?=			NGCwc2tKdmirYnn0bY9vKG:oIGDES2ZT[mW2YTDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGE{OSClZXzsd{BjgSCHTFnTRUwhUUN3ME2wMlA4Os7:TT6=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
GIST882	NV[4c5lSTnWwY4Tpc44h[XO\|YYm=			NFPTXphKdmirYnn0bY9vKG:oIHj1cYFvKEuLVDDheZRweGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYomgSWxKW0FuIFnDOVA:OC5yOUhOwG0v	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
GIST882	NULSTHkySW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			M1[1OGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{whUUN3ME2wMlExQM7:TT6=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
HEK293	MmDqSpVv[3Srb36gZZN{[Xl?			NWDoTXc6UW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKESGUkKg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OD1yLkG0Ne69VS5?	NE\leG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
Ba/F	MkHwSpVv[3Srb36gZZN{[Xl?			NWnpUnUxUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKEKFUj3BRmwyKGW6cILld5Nm\CCrbjDCZU9HKGOnbHzzMEBKSzVyPUCuNlIy\|ryPLh?=	NYLHOZVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
K562	M4fafmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MnnlRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|LDDJR\|UxRTBwMkS0{txONg>?	NVX5OYNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
HEK293	M4myXWZ2dmO2aX;uJIF{e2G7			NGnxd29KdmirYnn0bY9vKG:oIHH1eI9xcG:\|cHjvdplt[XSrb36gc4YhS1OIMWKg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OD1yLkK5Ne69VS5?	M1zpO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
M-NFS-60	NX\nN3JFSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			M2ruN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViTT3OSnMuPjBiY3XscJMtKEmFNUC9NE4{PTkQvF2u	NGi0[Wg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
K562	MV;GeY5kfGmxbjDhd5NigQ>?			MmKwTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFu1OlIh[2WubIOsJGlEPTB;MD60O\|PPxE1w	MlzBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
BA/F3	NHzlepJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLDVk1CSkxzIITyZY5{\mWldHXkJI1wfXOnIFLBM2Y{KGOnbHzzMEBKSzVyPUCuOlc5\|ryPLh?=	NV;DUohuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3	NWDiS\|JLSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			NVf3TlVlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhdW:3c3WgRmEwTjNiY3XscJMhcW5icILld4Vv[2Vib3[gbY51\XKuZYXrbY4hOyxiSVO1NF06NjR3Od88UU4>	MkHOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
K562	M{LyV2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M3HlUFQ5KGi{cx?=	MkTBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyPUCuOVjPxE1w	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ7NUO4NEc,OjF{OUWzPFA9N2F-
K562	NHT5bFFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NGL0S\|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIHntZZRqdmmkLYLld4l{fGGwdDDLOVYzKGOnbHzzMEBKSzVyPUCuNFA3ODYQvF2u	NWnsWnRWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO\|Y2QDdpPkKxN\|c3PTh5PD;hQi=>
KU812	Ml;PRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M{TEUGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOsJGlEPTB;MD6zN\|fPxE1w	NVeyNVQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO\|Y2QDdpPkKxN\|c3PTh5PD;hQi=>
K562	M1jpe2FvfGmycn;sbYZmemG2aY\lJIF{e2G7			M4HFXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczygTWM2OD1yLkO4{txONg>?	NHfiPFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3OlU5Pyd-MkGzO\|Y2QDd:L3G+
Sf9	M3zTbWZ2dmO2aX;uJIF{e2G7			NGn5VGlDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJIFkfGm4ZTDzbZRmKG:oIF6teIVzdWmwYXygbIV5[Wirc4Tp[Ilv\S22YXfn[YQhSUKOMjDlfJBz\XO\|ZXSgbY4hXHKrY3jvdIx2e2mjIH7pJIlv\mWldHXkJHNnQSClZXzsd{BjgSCrc3;0bIVzdWGuIITpeJJifGmxbjDjZYxwemmvZYTybYMh[XO\|YYmsJGtlRTBwMEC2{txONg>?	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTRzN{O0N{c,OjF2MUezOFM9N2F-
Sf9	M{LWbmZ2dmO2aX;uJIF{e2G7			NFfn[YVDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJJJmdW:2ZTDzbZRmKG:oIF6teIVzdWmwYXygbIV5[Wirc4Tp[Ilv\S22YXfn[YQhSUKOMjDlfJBz\XO\|ZXSgbY4hXHKrY3jvdIx2e2mjIH7pJIlv\mWldHXkJHNnQSClZXzsd{BjgSCrc3;0bIVzdWGuIITpeJJifGmxbjDjZYxwemmvZYTybYMh[XO\|YYmsJGtlRTBwNd88UU4>	Ml3nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUezOFMoRjJzNEG3N\|Q{RC:jPh?=
K562	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NFTNUoE1QCCqcoO=	NGHWPYlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD13LkVOwG0v	NYHlUVFwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1O\|YxOjNpPkKxOVc3ODJ\|PD;hQi=>
Ba/F3	M2mzeGZ2dmO2aX;uJIF{e2G7	NV3TZ3U{OSC3TR?=	MmjiNlQhcHK\|	NV7HS45OUW6qaXLpeIlwdiCxZjCxOE0{NTO\|aXftZUBqdiCqdX3hckBD[S:IMzDj[YxteyCneIDy[ZN{cW6pIIfpcIQhfHmyZTDCZ5IuSWKuIHPvcpN1enWldDDhd5Nme3OnZDDhd{Bz\WynYYPlJI9nKG[3bHytcIVv\3SqIHOtRYJtKG[{b32gZ5l1d3CuYYPtbYMh[2:vcHzlfEB4cXSqIEG0MVMuO3OrZ33hJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IHntcZVvd3C{ZXPpdIl1[XSrb36vbY1ufW6xYnzveEB1\WOqbnnxeYU>	MnjOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkK1O\|YoRjJzOU[yOVc3RC:jPh?=
Ba/F3	NHvMSG9HfW6ldHnvckBie3OjeR?=	MUCxJJVO	NIXrVGUzPCCqcoO=	NH\uRVBKdmirYnn0bY9vKG:oIEG0MVMuO3OrZ33hJIlvKGi3bXHuJGJiN0Z\|IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFLjdk1C[mxiY3;ud5RzfWO2IHHzd4V{e2WmIHHzJI52[2ynYYKgbY1xd3K2IH;mJIZ2dGxvbHXu[5RpKGNvQXLsJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IHntcZVvd3C{ZXPpdIl1[XSrb36vbY1ufW6xYnzveEB1\WOqbnnxeYU>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl4MkW3Okc,OjF7NkK1O\|Y9N2F-
K562	NHLHXolHfW6ldHnvckBie3OjeR?=		MmnjOkBpenN?	NFrZVoZKdmirYnn0bY9vKG:oIFLDVk1CSkxvbXXkbYF1\WRiU2TBWFUheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOkBpenNiYomgdIhwe3Cqbz3mcI94KGO7dH;t[ZRzgQ>?	NUj6Xo5[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFg2QDRpPkKyNVQ5PTh2PD;hQi=>
K562	NFrCVnJHfW6ldHnvckBie3OjeR?=	MVG0NEB2VQ>?	MVG2JIhzew>?	MmjOTY5pcWKrdHnvckBw\iCEQ2KtRWJNNW2nZHnheIVlKEWUS{GgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFu1OlIh[2WubIOgZZQhPDBidV2gZYZ1\XJiNjDodpMh[nlicHjvd5Bpdy2obH;3JIN6fG:vZYTyfS=>	NG\PeFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0PFU5PCd-MkKxOFg2QDR:L3G+
K562	NYPVdWt[TnWwY4Tpc44h[XO\|YYm=	NF\QNYk1OCC3TR?=	NGPQZY03KGi{cx?=	NWW5OYFxUW6qaXLpeIlwdiCxZjDCR3IuSUKOLX3l[IlifGWmIFXST\|IheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[XRiNECgeW0h[W[2ZYKgOkBpenNiYomgdIhwe3Cqbz3mcI94KGO7dH;t[ZRzgQ>?	M1HGe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUS4OVg1Lz5{MkG0PFU5PDxxYU6=
TF1	NI\pWnZEgXSxdH;4bYNqfHliYYPzZZk>			Ml\FR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGYyKGOnbHzzJIV5eHKnc4Ppcoch[y2NSWSgcZV1[XSrb36gZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImsJGlEPTB;MD6wNVPPxE1w	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{MUKwNUc,OjJ{MkGyNFE9N2F-
primary leukemia cells	NFj1VIxEgXSxdH;4bYNqfHliYYPzZZk>		NUXHXFFQPzJiaILz	NXXzPYYxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO\|aX7nJJdqdGRidInw[UBHVFR\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCLQ{WwQVAvOc7:TT6=	M1PRdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
primary leukemia cells	Mnj6R5l1d3SxeHnjbZR6KGG\|c3H5		M1SwblczKGi{cx?=	M3e3VmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzDGUHQ{NUR6M{XZJI12fGG2aX;uJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJIF{e2G7LDDJR\|UxRTBwNd88UU4>	Ml3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
K562	MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NFLqXIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOsJGdKPTB;MD6xO:69VS5?	Ml;IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{m2O\|QoRjJ{NEO5Olc1RC:jPh?=
HUVEC	M1zuPWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			M1f5S2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTHVXTUNiY3XscJMtKEeLNUC9NVgvPc7:TT6=	NHq2UJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzPVY4PCd-MkK0N\|k3PzR:L3G+
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K562	NXvWVXFKS3m2b4TvfIlkcXS7IHHzd4F6		M4n1RVQ5KHSxIEeyJIhzew>?	M2m1c2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJEWi2DQlygdI9{cXSrdnWgT\|U3OiClZXzsd{Bi\nSncjC0PEB1dyB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwM{i0OO69VS5?	NXTJSJdQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3PFk1OjlpPkKyO\|g6PDJ7PD;hQi=>
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HEK293	NFXUR3VHfW6ldHnvckBie3OjeR?=		NXHKbplmOyCvaX7z	MUTJcohq[mm2aX;uJI9nKGi3bXHuJG9EXDNvbXXkbYF1\WRiQWPQL{B2eHSja3Wg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDh[pRmeiB\|IH3pcpMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR\|UxRTJ3LkZOwG0v	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
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insect cells	MorjSpVv[3Srb36gZZN{[Xl?		M2f0WFMxKG2rboO=	M4PCZ2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBOOzVzVDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVA:OC5zMUSz{txONg>?	NEjrNFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells	M{LZWWZ2dmO2aX;uJIF{e2G7		MX2zNEBucW6\|	M3qzXWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBSOjV{SDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVA:OC5zMUZOwG0v	NHPyT289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
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GIST882	M2LSdWZ2dmO2aX;uJIF{e2G7			NWDXSGczUW6qaXLpeIlwdiCxZjDLTXQhUzZ2MlWgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCDVGCt[IVxdGW2aX;uJIF{e2G7LDDJR\|UxRTBwMUC4{txONg>?	MoLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O\|EoRjJ\|NkGxO\|cyRC:jPh?=
32D	MmP4SpVv[3Srb36gZZN{[Xl?			NYfLd4diUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SB\|MlSgZ4VtdHNuIFnDOVA:OC5zOUVOwG0v	M4K3dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
BA/F3	M3vt[GZ2dmO2aX;uJIF{e2G7			MVnJcohq[mm2aX;uJI9nKGi3bXHuJGJEWi2DQlyxJIF2fG:yaH;zdIhwenmuYYTpc44h\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHL5JGVNUVODLDDJR\|UxRTBwMkKx{txONg>?	M4PUV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
BA/F3	NXLVeldtTnWwY4Tpc44h[XO\|YYm=			NXTUN5ZJUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBCXFBvZHXwcIV1cW:wIHHzd4F6NCCLQ{WwQVAvPjd6zszNMi=>	NXv1eWR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
K562	MnHsR5l1d3SxeHnjbZR6KGG\|c3H5		M{jEUFQ5KGi{cx?=	NVHXb2xsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTBwNEhOwG0v	MoXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{W4NlYoRjJ\|N{O1PFI3RC:jPh?=
GISTT1	M{X0WWZ2dmO2aX;uJIF{e2G7		NGf3V4U4OiCqcoO=	M2nkeWlvcGmkaYTpc44hd2ZiS1nUJIlvKGi3bXHuJGdKW1SWMTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDHTVUxRTBwMEJOwG0v	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd5M{G1N{c,OjN5N{OxOVM9N2F-
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K562	M3fvUWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mny3OFghcHK\|	MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjYQvF2u	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl\|MkC3NUc,OjN7M{KwO\|E9N2F-
HepG2	MnfpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NEPTRngzPCC2bzC5OkBpenN?	NEXv[pJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEK0JJRwKDl4IHjyd{BjgSCPVGOgZZN{[XluIFnDOVA:OTEQvF2u	MkPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO\|EoRjJ\|OUOyNFcyRC:jPh?=
K562	M3rje2N6fG:2b4jpZ4l1gSCjc4PhfS=>		Mon6O\|IhcHK\|	NUflXldvS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[2GuY3Xpck1CVSCjc4PhfUwhUUN3ME2wMlXPxE1w	NHjwNVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m4NVU{Oid-MkO5PFE2OzJ:L3G+
Sf9	NEXwdFdHfW6ldHnvckBie3OjeR?=			MkXPTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDBZowhc2mwYYPlJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyC3c3nu[{BIT0WDSWnBRXBHU0tiYYOgd5Vje3S{YYTlJIlvKHC{ZYPlcoNmKG:oIGvnZY1u[TN\|UG3BWHAtKEmFNUC9NE4{\|ryPLh?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUm4Okc,OjR4OEG5PFY9N2F-
K562	NV\YUGZqSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEDYbmgzPCCqcoO=	MVfJckB3cXS{bzDhcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDD2bYFjcWyrdImgZYZ1\XJiMkSgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zM988UU4>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ6MUm4Okc,OjR4OEG5PFY9N2F-
BV173	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MYeyOEBpenN?	MYTJckB3cXS{bzDhcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKYMUezJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTB;MkFOwG0v	NFG5SW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
CCRF-CEM	NXm5cHJVSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NEjzN40zPCCqcoO=	MY\JckB3cXS{bzDhcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tR2VOKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUC9OFXPxE1w	Ml3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
K562	MYXGeY5kfGmxbjDhd5NigQ>?	M37zNVExKHWP	NV7TUWVEOSCqch?=	NYPmTnhmUW6qaXLpeIlwdiCxZjDCZ5IwSWKuIHvpcoF{\SC2eYLvd4lv\SCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hUzV4MjDj[YxteyCjdDCxNEB2VSCjZoTldkAyKGi{IHL5JIludXWwb3Lsc5Qh[W6jbInzbZM>	Mnj2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
K562	NGe5UVhHfW6ldHnvckBie3OjeR?=	Mnq5NVAhfU1?	MmP2NUBpeg>?	MmW0TY5pcWKrdHnvckBw\iCDYnygb4lv[XOnIIT5do9{cW6nIIDoc5NxcG:{eXzheIlwdiCrbjDoeY1idiCNNU[yJINmdGy\|IHH0JFExKHWPIHHmeIVzKDFiaIKgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>?	MnrpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
K562	NHjlR\|lHfW6ldHnvckBie3OjeR?=	NXTnfpJbOTBidV2=	NY\P[5lyOSCqch?=	NFvabG1KdmirYnn0bY9vKG:oIIT5do9{cW6nIIDoc5NxcG:{eXzheIlwdiCxZjDwdo91\WmwIIfpeIghdW:uZXP1cIFzKHenaXfoeEBj\XS5ZXXuJFQxKGGwZDC2NEBsTGFiaX6gbJVu[W5iS{W2NkBk\WyuczDheEAyOCC3TTDh[pRmeiBzIHjyJIJ6KGmvbYXuc4Jtd3RiYX7hcJl{cXN?	NFHNZ5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
HGC27	NWTZfXRDS3m2b4TvfIlkcXS7IHHzd4F6		MYm0PEBpenN?	NYHUb4JsS3m2b4TvfIlkcXS7IHHnZYlve3RiSFfDNlch[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1\|LklOwG0v	NXPDR5dlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA2QDRpPkK0PVAxPTh2PD;hQi=>
HMC-1.2	NELiUHNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NYjLXWxXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUWMuOS5{IHPlcIx{KGOjcoL5bY5oKFZ3NkDHMEBFQDF4VjDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO\|YYmsJGlEPTB;MUhOwG0v	NIrNV4o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwOFQxQSd-MkWwNFQ1ODl:L3G+
K562	MnvzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NEfVOYE1QCCqcoO=	MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLjdk9C[mxicH;zbZRqfmViaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NF01NjF{zszNMi=>	NF3jVnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2OFg5Pid-MkW0OlQ5QDZ:L3G+
K562	MYjDfZRwfG:6aXPpeJkh[XO\|YYm=		MYS3NkBpenN?	M2q0d2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IIXzbY5oKEOjbHPlbY4hSU1iYomg[ox2d3Knc3PlcoNmKGG\|c3H5MEBKSzVyPUCuOe69VS5?	MoiwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NUe2NFMoRjJ3N{W3OlA{RC:jPh?=
K562	M{fnSWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M3jFeVQ5KGi{cx?=	NEjXZpRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkS3{txONg>?	NXjMXXhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3O\|g4PjZpPkK1O\|c5PzZ4PD;hQi=>
K562	M3LoemFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M{fFd\|czKGi{cx?=	NUH3ZnlrSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwQVAvOjkQvF2u	M3q1eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUm1NVM3Lz5{NkG5OVE{PjxxYU6=
K562	M3PHZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MVO0PEBpenN?	M1PWW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTFwMUdOwG0v	NXjUWlZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[yN\|ExPzlpPkK2NlMyODd7PD;hQi=>
K562	M{f0WWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MlvEOFghcHK\|	MkjTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDpcYF1cW6rYj3y[ZNqe3SjboSgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxRTF3LkhOwG0v	M{TXS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkOxNFc6Lz5{NkKzNVA4QTxxYU6=
K562	MlXYR5l1d3SxeHnjbZR6KGG\|c3H5			MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSxiSVO1NF0xNjB4zszNMi=>	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
IR-K562	M{jwcGN6fG:2b4jpZ4l1gSCjc4PhfS=>			NInD[XZEgXSxdH;4bYNqfHliYXfhbY5{fCCrbXH0bY5q[iC{ZYPpd5RidnRiaIXtZY4hUVJvS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJktKEmFNUC9NU4y\|ryPLh?=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
HEK293	NUnkfYxCS3m2b4TvfIlkcXS7IHHzd4F6			MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5MEBESzVyPUiuOO69VS5?	M3[5ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mk[0OVA{Lz5{NkK2OFUxOzxxYU6=
U937	NYj4eW1LS3m2b4TvfIlkcXS7IHHzd4F6			MlWzR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWVk{PyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHluIFnDOVA:OToQvF2u	MkTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NkS1NFMoRjJ4Mk[0OVA{RC:jPh?=
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GIST430	NUHYPGNiSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoXTNVIxKGi{cx?=	NHjVWXJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q1OzBiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJIV5d25iMUGgdJJqdWG{eTDpck1nemGvZTDWOVYxNUx3N{[g[IVt\XSrb36gcZV1[W62IHHu[EBmgG:wIEGzJIhmfGW{b4r5[492eyC\|ZXPvcoRienlibXnzd4Vve2ViVk[1OGEhdXW2YX70JIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiMUKwJIhzeyCkeTDt[ZRpgWynbnWgZox2\SC\|dHHpcolv\yBuIFfJOVA:OC54MkZOwG0v	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTd{MUW3PEc,OzF5MkG1O\|g9N2F-
GIST48	M{XOVmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2\WTlEzOCCqcoO=	MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S0PEBk\WyuczDoZZJjd3KrbnegZ{1MUVRiZYjvckAyOSCqb33vfplod3W\|IIDybY1ienlibXnzd4Vve2ViVkW2NGQhdXW2YX70JIFv\CCneH;uJFE4KGindHXyc5p6\2:3czDz[YNwdmSjcomgSFgzOEFibYX0ZY51KGG\|c3Xzd4VlKGG\|IHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgNVIxKGi{czDifUBu\XSqeXzlcoUh[my3ZTDzeIFqdmmwZzDiZZNm\CCjc4PhfUwhT0l3ME2wMlkzQc7:TT6=	MkDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF5MkG1O\|goRjNzN{KxOVc5RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5 ; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho STAT3, anti-STAT3, anti-phospho STAT5 or anti-STAT5 Abs. p-ZAP70 / ZAP70 / p-LAT / LAT ; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-activated cells were used as controls (NA). p-STAT3 / STAT3 / p-STAT5 / STAT5 ; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho STAT3, anti-STAT3, anti-phospho STAT5 or anti-STAT5 Abs. p-ZAP70 / ZAP70 / p-LAT / LAT ; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-activated cells were used as controls (NA).	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin ; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at invadopodia. RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry. Cortactin / F-actin ; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at invadopodia.	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone. Abbreviations: IM, imatinib; SD, standard deviation.	28435223

In vivo

Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. ^[5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. ^[6]

Protocol

Kinase Assay:

^[1]

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PDGF receptor kinase activity:

PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl₂). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-³³P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.

Cell Research:

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Cell lines: BON-1 cells and NCI-H727 cells
Concentrations: ~100 μM
Incubation Time: 48 hours
Method:
BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively.

(Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	33 mg/mL (66.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 2% DMSO+30% PEG 300+2% Tween 80+ddH2O For best results, use promptly after mixing.	2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Imatinib (STI571) SDF

Molecular Weight	493.6
Formula	C₂₉H₃₁N₇O
CAS No.	152459-95-5
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Gleevec, Glivec, CGP057148B
Smiles	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

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Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

% DMSO+ % + % Tween 80+ % ddH₂O

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Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03891901	Recruiting	Drug: Imatinib\|Drug: Isoniazid\|Drug: Rifabutin	Tuberculosis	National Institute of Allergy and Infectious Diseases (NIAID)	November 30 2020	Phase 2
NCT04326933	Not yet recruiting	Drug: Tyrosine kinase Inhibitors (Imatinib & Nilotinib)	Patients Diagnosed as Chronic Meyloid Leukemia	Assiut University	October 20 2020	--
NCT04357613	Not yet recruiting	Drug: Experimental drug	SARS Virus	Versailles Hospital	September 1 2020	Phase 2
NCT04422678	Not yet recruiting	Drug: Imatinib Mesylate\|Drug: Standard of Care	COVID-19	Alexandria University\|Science Technology & Innovation Funding Authority (STIFA) Egypt	June 2020	Phase 3
NCT04097093	Withdrawn	Other: No intervention	GIST	European Organisation for Research and Treatment of Cancer - EORTC	June 1 2020	--
NCT03997903	Not yet recruiting	Drug: Imatinib Mesylate	Sickle Cell Disease	Indiana University\|Purdue University\|Children''s Hospital Medical Center Cincinnati	February 26 2020	Early Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
Could you please advise whether it is a clear solution for compound dissolved in vehicle 2% DMSO+30% PEG 300+2% Tween 80+ddH2O?
Answer:
For S2475 Imatinib (STI571), it is soluble in 2% DMSO+30% PEG 300+2% Tween 80+ddH2O at 2mg/ml. When making the solution, please dissolve the compound in DMSO clearly first. If it dissolves not readily, please sonicate and warm it in water bath at 45-50C. Then add PEG and Tween. After they mixed well, dilute with water.
Question 2:
What is the difference between S2475 (Imatinib) and S1026 (Imatinib Mesylate)? Are they water soluble?
Answer:
S2475 is free base of Imatinib while S1026 is a solt form of Imatinib. They have exactly the same biological activity but different solubility. S1026 can be dissolved in water, but S2475 is not soluble in water. S2475 can be dissolved in DMSO at up to 3mg/ml.

PDGFR Signaling Pathway Map

PDGFR Inhibitors with Unique Features

Selective PDGFR Inhibitor

Sunitinib Malate : PDGFRβ-selective, IC50=2 nM.
Most Potent PDGFR Inhibitors

Axitinib : PDGFRβ, IC50=1.6 nM.
Most Potent PDGFR Inhibitors

Ponatinib (AP24534) : PDGFRα, IC50=1.1 nM.
FDA-approved PDGFR Inhibitor

Imatinib Mesylate (STI571) : Approved by FDA for CML, GISTs and a number of other malignancies.
Newest PDGFR Inhibitor

Tyrphostin AG 1296 : Inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.

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Imatinib (STI571)