Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Oxaliplatin

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Oxaliplatin DNA Synthesis inhibitor

Cat.No.S1224

Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Oxaliplatin DNA/RNA Synthesis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 397.29
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Quality Control

Batch: Purity: 99.78%
99.78

Solubility in DMSO or Water

In vitro
Batch:

Water : 2 mg/mL

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Read more about Oxaliplatin solubility in DMSO or water

Working Concentrations for Cell Culture Treatment

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Read more about Oxaliplatin working concentrations for cell culture treatment

Working Concentrations for Animal Model Treatment

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Mechanism of Action

Information Oxaliplatin is a potent DNA cross-linker. It affects DDR and p53 signaling by forming Pt-DNA adducts, promoting apoptosis.

Read more about Oxaliplatin IC50 for cell-based and cell-free assays
Primary Applications and Mechanism of Action

Read more about Oxaliplatin Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight 397.29 Formula

C8H14N2O4Pt

 Storage (From the date of receipt) 2 years 4°C(in the dark) powder
CAS No. 61825-94-3 Download SDF Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms L-OHP,NSC 266046 Smiles C1CCC(C(C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2]

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Read more comparative analysis about Oxaliplatin

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

Question 1:
Is it ok to dissolve it in saline?

Answer:
When dissolved in saline, it is partially converted to cisplatin and L-isomers. The L-isomer of this compound is inactive. DMF is a better choice.

Question 2:
Is it ok to dissolve it in DMSO?

Answer:
Even though it is soluble in DMSO, the use of DMSO to dissolve this compound in biological studies is strongly discouraged. The DMSO inserts itself into the ligand and inactivates platin-containing compounds. DMF is a much better choice than DMSO.