Obatoclax Mesylate (GX15-070)

For research use only.

Catalog No.S1057

86 publications

Obatoclax Mesylate (GX15-070) Chemical Structure

CAS No. 803712-79-0

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Selleck's Obatoclax Mesylate (GX15-070) has been cited by 86 publications

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Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULveFVxUUN3ME2wMlAxODB|MUeg{txO MkLkV2FPT0WU
SK-MEL-30 NHHUbWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTETWM2OD1yLkCwNFM2PSEQvF2= NYHGOFJHW0GQR1XS
NALM-6 NVHEXIZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TSWmlEPTB;MD6wNFA{PTZizszN M2O3c3NCVkeHUh?=
KYSE-450 NVzBS3FYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfMd2ZqUUN3ME2wMlAxODR4OTFOwG0> NGjyNHJUSU6JRWK=
BHY NELS[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvDb21KSzVyPUCuNFAxPjBzIN88US=> NWjxcZlOW0GQR1XS
GR-ST M4HueGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{THOGlEPTB;MD6wNFA3PDhizszN MnzBV2FPT0WU
786-0 M3:3Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfxbGhKSzVyPUCuNFAxPzd4IN88US=> M1PReHNCVkeHUh?=
C-33-A NEnK[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPzTWM2OD1yLkCwNFg1QCEQvF2= M4rXSXNCVkeHUh?=
BHT-101 NVqyb2R2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PIe2lEPTB;MD6wNFExPiEQvF2= MV\TRW5ITVJ?
EB2 NIm3PJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELwbGhKSzVyPUCuNFAyOThizszN MUXTRW5ITVJ?
G-361 NWnBO5I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnocIhKSzVyPUCuNFAyOjRizszN NF;qfVZUSU6JRWK=
KE-37 M2nKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fIdWlEPTB;MD6wNFEzQCEQvF2= Mm\ZV2FPT0WU
MHH-PREB-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLiTWM2OD1yLkCwNVQh|ryP MV;TRW5ITVJ?
MCF7 NFznNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMECxOVkh|ryP MojRV2FPT0WU
LOUCY NFfIbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKzdVE6UUN3ME2wMlAxOTd3IN88US=> NFT6TXpUSU6JRWK=
EW-7 M4jIcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjLXZhKSzVyPUCuNFAyPzVizszN NXPMS3ppW0GQR1XS
KYSE-510 M3n0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMECyN|Mh|ryP NFTjfpJUSU6JRWK=
SK-MEL-3 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D6XmlEPTB;MD6wNFI3PCEQvF2= M3rqT3NCVkeHUh?=
HAL-01 NFX1dYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXD[|dKSzVyPUCuNFAzQTdizszN NULaVlBNW0GQR1XS
HCC2998 NYC2fGFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMECzN|Uh|ryP MmfkV2FPT0WU
A375 NH3YW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMECzOUDPxE1? MYfTRW5ITVJ?
MZ7-mel NF75XXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLHXIg2UUN3ME2wMlAxOzl7IN88US=> MoG2V2FPT0WU
SH-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn0dndKSzVyPUCuNFA1OTdizszN Mmf3V2FPT0WU
HT-144 NY[xSHdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j4O2lEPTB;MD6wNFQ{KM7:TR?= NEjFWY1USU6JRWK=
KYSE-140 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHUfGN7UUN3ME2wMlAxPDN3IN88US=> NVjqVolQW0GQR1XS
PSN1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrGO4hGUUN3ME2wMlAxPDZ5IN88US=> MUjTRW5ITVJ?
COLO-679 M3Lyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3mzWWlEPTB;MD6wNFQ6QCEQvF2= M3v1SnNCVkeHUh?=
SW620 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7Y[mh{UUN3ME2wMlAxPTFzIN88US=> NH;JdpFUSU6JRWK=
HGC-27 NUiwPYp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHyTWM2OD1yLkCwOVI1KM7:TR?= MlrLV2FPT0WU
IGROV-1 Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEC2JO69VQ>? NEfBVWdUSU6JRWK=
IGR-1 NX3aepVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TB[GlEPTB;MD6wNFYxOSEQvF2= M3PqU3NCVkeHUh?=
EW-1 M3mzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi1dnk2UUN3ME2wMlAxPjVzIN88US=> Mn\hV2FPT0WU
769-P M13pcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjHclZGUUN3ME2wMlAxPjd6IN88US=> M4fVNHNCVkeHUh?=
HN M3TCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljYTWM2OD1yLkCwOlc6KM7:TR?= NH\LRYJUSU6JRWK=
SIG-M5 MnyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEC3NUDPxE1? MUjTRW5ITVJ?
IST-MEL1 MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXIeYpKSzVyPUCuNFA5OThizszN M1rMWXNCVkeHUh?=
ST486 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfGTWM2OD1yLkCwPFI2KM7:TR?= MXvTRW5ITVJ?
ES7 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG4TWM2OD1yLkCwPFQ3KM7:TR?= M1\XPXNCVkeHUh?=
GAK M4fpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLvNGZJUUN3ME2wMlAxQDR6IN88US=> MkW1V2FPT0WU
BB30-HNC Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXvd2pKSzVyPUCuNFA5PThizszN Moq1V2FPT0WU
IPC-298 NV[yVnZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XMcGlEPTB;MD6wNFkzPyEQvF2= NInqS3dUSU6JRWK=
NKM-1 M4\V[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEC5O|Ih|ryP M4qwNHNCVkeHUh?=
RKO M2m4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEGwOFQh|ryP NGj3O4ZUSU6JRWK=
ACN MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz4NJZKSzVyPUCuNFEyOzFizszN MnHZV2FPT0WU
SW1417 NV3hXo9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDFeXNKSzVyPUCuNFEzOjVizszN NHvnPYNUSU6JRWK=
SR M1HNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M374[mlEPTB;MD6wNVI{PSEQvF2= MVjTRW5ITVJ?
SNG-M M3fkdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTiTWM2OD1yLkCxN|E4KM7:TR?= Mmm4V2FPT0WU
CAL-12T NVTyZm1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVniUWhsUUN3ME2wMlAyOzR4IN88US=> MVzTRW5ITVJ?
HSC-3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEGzOVUh|ryP M4TFUXNCVkeHUh?=
DOHH-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzXPYVlUUN3ME2wMlAyPDF{IN88US=> MVTTRW5ITVJ?
NB69 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPXO49KSzVyPUCuNFE2PjVizszN M33IV3NCVkeHUh?=
LC-2-ad MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLYTWM2OD1yLkCxOVgyKM7:TR?= MoL2V2FPT0WU
RVH-421 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK5dFJKSzVyPUCuNFE3PzRizszN NGjjeWdUSU6JRWK=
TGW MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoriTWM2OD1yLkCxO|M6KM7:TR?= MWjTRW5ITVJ?
HCC1569 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLu[29oUUN3ME2wMlAyPzl5IN88US=> NIfPV3FUSU6JRWK=
CAL-85-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEG4N|Ih|ryP NYXFVmM5W0GQR1XS
RPMI-8402 NULtcolnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfUTWM2OD1yLkCxPFU5KM7:TR?= MoGwV2FPT0WU
THP-1 NUWxSYVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[zbIpKSzVyPUCuNFE6QThizszN MU\TRW5ITVJ?
ONS-76 M17Ofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO0NoZKSzVyPUCuNFIxOzZizszN NXiySG9OW0GQR1XS
A2780 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3WTWM2OD1yLkCyNFc6KM7:TR?= MnTqV2FPT0WU
RPMI-2650 M1TNU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwMEKyPVYh|ryP NVqwSlBxW0GQR1XS
MEL-HO NYDIWpZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jpcGlEPTB;MD6wNlM1QCEQvF2= NVjpdotkW0GQR1XS
MC-CAR NG\YOpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEKzOVYh|ryP Ml7zV2FPT0WU
HSC-2 NGn5cHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYKwOVF3UUN3ME2wMlAzPDZ4IN88US=> NYDLdWt7W0GQR1XS
MEL-JUSO Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W5TWlEPTB;MD6wNlQ4OyEQvF2= Mmj5V2FPT0WU
CAL-62 M1PCU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMEK2NFIh|ryP M2fBPXNCVkeHUh?=
DMS-273 MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEK4OFch|ryP NFLtUIVUSU6JRWK=
S-117 MnLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3rTWM2OD1yLkCyPVA3KM7:TR?= Mo\RV2FPT0WU
SUP-T1 NH;mOY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPFTWM2OD1yLkCyPVQ6KM7:TR?= NUDkWm52W0GQR1XS
MZ2-MEL NUPTdm5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL2N4JzUUN3ME2wMlAzQTV7IN88US=> NWLvflRDW0GQR1XS
KYSE-270 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TzWmlEPTB;MD6wNlk4PiEQvF2= M4PGPXNCVkeHUh?=
CMK NFHhSWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEOwNlMh|ryP MmjBV2FPT0WU
8505C MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzxTWM2OD1yLkCzNFQh|ryP NFrrUGVUSU6JRWK=
NUGC-3 NFvyVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fmcmlEPTB;MD6wN|A1QCEQvF2= NG\vNW5USU6JRWK=
A101D MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW4TpVKSzVyPUCuNFMxPTVizszN NH3Ndo9USU6JRWK=
G-401 MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMEOwPVMh|ryP NFvGcYRUSU6JRWK=
OVCAR-8 NWG2SpZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEOxNFch|ryP NV\mPYlmW0GQR1XS
IMR-5 NF;VU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETQc3ZKSzVyPUCuNFMzPDRizszN MoDvV2FPT0WU
DoTc2-4510 NGradHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvmTWM2OD1yLkCzN|k{KM7:TR?= M2Loc3NCVkeHUh?=
HOS NG[4UlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7VO4dKSzVyPUCuNFM1PzNizszN MYXTRW5ITVJ?
HEC-1 NIHFc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEO2PEDPxE1? NHfCO|ZUSU6JRWK=
SW756 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLOVI9KSzVyPUCuNFM5OjFizszN M1vxdnNCVkeHUh?=
NCI-H64 M2jFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMEO4OFIh|ryP M1nYZ3NCVkeHUh?=
EW-16 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX0TWM2OD1yLkCzPVA6KM7:TR?= MWLTRW5ITVJ?
CAL-51 NHPrR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f5d2lEPTB;MD6wOFAxPSEQvF2= MV;TRW5ITVJ?
KYSE-150 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSxOINKSzVyPUCuNFQxOTFizszN M4TQO3NCVkeHUh?=
SW1710 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\MO4hDUUN3ME2wMlA1ODF6IN88US=> MUPTRW5ITVJ?
HuP-T4 M2LDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPKNpVXUUN3ME2wMlA1OTF6IN88US=> NVmxW444W0GQR1XS
LB373-MEL-D M2DUSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7EcFNKSzVyPUCuNFQzOzJizszN MXPTRW5ITVJ?
EW-13 NHftU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHjTWM2OD1yLkC0OFA3KM7:TR?= NHjmN|hUSU6JRWK=
HT-29 M3O1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr1bmpEUUN3ME2wMlA1PDlizszN NEC4[W9USU6JRWK=
SCC-25 M{jtXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMES0PVQh|ryP MoKxV2FPT0WU
REH MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzRV2J[UUN3ME2wMlA1PjN3IN88US=> MWTTRW5ITVJ?
L-363 NE\PS2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\iTWxKSzVyPUCuNFQ3PzlizszN NYewfldtW0GQR1XS
NCI-H1770 NEjCVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjZcXJKSzVyPUCuNFQ3QTdizszN MnvhV2FPT0WU
CHL-1 NH\uU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTHPZVLUUN3ME2wMlA1QDV5IN88US=> NIDYdlZUSU6JRWK=
ES1 M2n4Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\YfVVvUUN3ME2wMlA1QDh3IN88US=> MVvTRW5ITVJ?
SCC-15 M3G3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwMES5NFIh|ryP NGHjdpFUSU6JRWK=
MRK-nu-1 MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfYXWVDUUN3ME2wMlA1QTN4IN88US=> MkDwV2FPT0WU
PF-382 NVXMeXN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXOTWM2OD1yLkC0PVM6KM7:TR?= M1qxT3NCVkeHUh?=
COLO-680N NVznbW1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nJSGlEPTB;MD6wOVA1PyEQvF2= M{DRSHNCVkeHUh?=
LK-2 MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEWwOlMh|ryP M13DSnNCVkeHUh?=
NCI-H2342 NUWzPVZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEWxNVch|ryP M3u4bHNCVkeHUh?=
HMV-II M1H2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKzTWM2OD1yLkC1NlM6KM7:TR?= MVnTRW5ITVJ?
PC-14 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHDNmtwUUN3ME2wMlA2OjV{IN88US=> NWL6dot{W0GQR1XS
COLO-320-HSR NVnrPYRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfXSVhKSzVyPUCuNFUzQDlizszN NVz0NJZtW0GQR1XS
697 NX3kblRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDNWGxKSzVyPUCuNFU{OjNizszN M4f0THNCVkeHUh?=
NEC8 NFnVXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfubVZKSzVyPUCuNFU2QSEQvF2= NY\UVHJnW0GQR1XS
LCLC-97TM1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHf2O5VKSzVyPUCuNFU2QTRizszN MoTLV2FPT0WU
Daoy M1j2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHm2V2ZKSzVyPUCuNFU3OTZizszN M2DNbHNCVkeHUh?=
ETK-1 NXLIcoJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj6c|duUUN3ME2wMlA2Pjd{IN88US=> Mn\WV2FPT0WU
A388 M4rqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEW2PVUh|ryP NXu5RZdtW0GQR1XS
COLO-205 MonsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXLTWM2OD1yLkC1O|E3KM7:TR?= MV3TRW5ITVJ?
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EB-3 M3TOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL2SnJVUUN3ME2wMlE4OzFizszN MkPGV2FPT0WU
HCC1143 NY\zdWNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq5dHBNUUN3ME2wMlE4Ozl4IN88US=> MlS4V2FPT0WU
DJM-1 NGrHc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLR[nNKSzVyPUCuNVc1PTFizszN MmTkV2FPT0WU
BT-474 NXHLfZVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HmTmlEPTB;MD6xO|Q5QSEQvF2= NISzN2pUSU6JRWK=
BB65-RCC M2DhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYexbG1vUUN3ME2wMlE4PTR3IN88US=> MkK1V2FPT0WU
NCI-H292 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLkTWM2OD1yLkG3OlAyKM7:TR?= M3\WXHNCVkeHUh?=
MKN28 NHXSZoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[0PXZvUUN3ME2wMlE4PjV|IN88US=> NEHqfW5USU6JRWK=
TK10 NXvqSJlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH32NWFKSzVyPUCuNVc4ODJizszN M1nTWnNCVkeHUh?=
TYK-nu NELPfJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDjWmlNUUN3ME2wMlE4QTR7IN88US=> NWHhWJZwW0GQR1XS
8305C MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;lTWM2OD1yLkG3PVcyKM7:TR?= MojnV2FPT0WU
MV-4-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMUe5O|ch|ryP NXH4UW5RW0GQR1XS
NCI-H522 MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMUiwPVQh|ryP MYjTRW5ITVJ?
Hs-578-T M4jFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTQdHJMUUN3ME2wMlE5Ojl{IN88US=> MmPyV2FPT0WU
LCLC-103H Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMUi1Nlch|ryP MlnDV2FPT0WU
MHH-ES-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmWzTWM2OD1yLkG4OlI6KM7:TR?= NUfKb5d5W0GQR1XS
NCI-H441 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjDTWM2OD1yLkG5NVQ5KM7:TR?= Moi4V2FPT0WU
AM-38 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMUmyNlUh|ryP M3v4UXNCVkeHUh?=
SW1783 NF3SbVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3vR|l3UUN3ME2wMlE6OzB3IN88US=> MXHTRW5ITVJ?
SK-HEP-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXT0U5BrUUN3ME2wMlE6PjN5IN88US=> MnflV2FPT0WU
OAW-28 NFLtVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrtfmVKSzVyPUCuNlAyPzhizszN NIraN2NUSU6JRWK=
TE-15 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n0OWlEPTB;MD6yNFI2OiEQvF2= NXnEdotbW0GQR1XS
HCE-4 NVnOemI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzTPZFKSzVyPUCuNlAzQDRizszN MmexV2FPT0WU
JiyoyeP-2003 NW[0NGVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMkCzN|Yh|ryP MmH6V2FPT0WU
OVCAR-4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HaVGlEPTB;MD6yNFYzQCEQvF2= NInIUY1USU6JRWK=
SNU-449 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrpeHdKSzVyPUCuNlA4QTdizszN NEnrT|NUSU6JRWK=
SBC-5 NUe0V2k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrpVYxKSzVyPUCuNlEzOTVizszN NUTaSopYW0GQR1XS
T84 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMkGyOFgh|ryP M2nLZXNCVkeHUh?=
LP-1 M4WxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\IRndIUUN3ME2wMlIyOzB{IN88US=> M1jGeXNCVkeHUh?=
MG-63 M37uOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TMXWlEPTB;MD6yNVM5OiEQvF2= MnX5V2FPT0WU
OAW-42 MnvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDS[olIUUN3ME2wMlIyPDd6IN88US=> MoX4V2FPT0WU
L-540 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMkG1PVgh|ryP MXfTRW5ITVJ?
RH-1 NX\tO2JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Xsc2lEPTB;MD6yNlI1OiEQvF2= MlTCV2FPT0WU
HCT-15 MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fn[GlEPTB;MD6yNlQ5PCEQvF2= NYTHRZNZW0GQR1XS
OCUB-M MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HydWlEPTB;MD6yNlQ5QCEQvF2= NILYNlZUSU6JRWK=
GP5d MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m4SmlEPTB;MD6yNlUzQCEQvF2= MUjTRW5ITVJ?
NCI-H2030 NUjTUFRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOxTWM2OD1yLkKyO|M1KM7:TR?= NIDDco1USU6JRWK=
ML-2 NFTLR3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHoRYpwUUN3ME2wMlIzQDh7IN88US=> M{j5Z3NCVkeHUh?=
CAL-39 M2XTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nIZWlEPTB;MD6yNlk{PiEQvF2= NGCzfXhUSU6JRWK=
MIA-PaCa-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMkOyPFch|ryP NF;qeZBUSU6JRWK=
TE-9 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrCTWM2OD1yLkKzN|Ih|ryP NFHje5RUSU6JRWK=
LB2518-MEL M12zVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjhdo1UUUN3ME2wMlI{Ozd{IN88US=> NYXqOWk5W0GQR1XS
DB NWf6Sm1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMkO0N|gh|ryP MYXTRW5ITVJ?
NCI-H596 MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT1SlFKSzVyPUCuNlM2PzFizszN MkDyV2FPT0WU
SW1990 M4fzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\p[YlKSzVyPUCuNlM6PDZizszN NGTDcYhUSU6JRWK=
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ALL-PO MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3uTWM2OD1yLkK0NVY6KM7:TR?= NXPYfWlpW0GQR1XS
Saos-2 MlqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrGToZtUUN3ME2wMlI1PTdzIN88US=> MkLBV2FPT0WU
MFH-ino NV[yOGk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfsb4JVUUN3ME2wMlI1Pjl{IN88US=> MlqwV2FPT0WU
OE33 NH7HeW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zJZ2lEPTB;MD6yOVEyKM7:TR?= NXf2cXZQW0GQR1XS
Calu-3 MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMkWyPVch|ryP M{X6SHNCVkeHUh?=
HT M3G2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMkW2NlEh|ryP MWPTRW5ITVJ?
LXF-289 MnrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG3bmdKSzVyPUCuNlU6QDRizszN MYPTRW5ITVJ?
KGN NHHQU4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMk[wPFkh|ryP NFnmeHlUSU6JRWK=
NCI-H1417 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DzSWlEPTB;MD6yOlUzPCEQvF2= MV\TRW5ITVJ?
SF126 NVTxTYFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfnTYVKSzVyPUCuNlc{ODJizszN NYXUUGxpW0GQR1XS
SAS NEHud4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\GdWhVUUN3ME2wMlI4OzB6IN88US=> NH;a[2RUSU6JRWK=
22RV1 Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PIVmlEPTB;MD6yO|M4QCEQvF2= MXzTRW5ITVJ?
GI-1 NFLae|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYWzfI1VUUN3ME2wMlI4PDh5IN88US=> M4H2WXNCVkeHUh?=
ES3 M1Kzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITTfoFKSzVyPUCuNlc4PjNizszN MXfTRW5ITVJ?
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NCI-H650 NVnHVnhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrKS3lvUUN3ME2wMlI5OzB{IN88US=> NUO2eo8yW0GQR1XS
IST-MES1 MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnpO3VYUUN3ME2wMlI5PTV2IN88US=> M4rONXNCVkeHUh?=
UM-UC-3 NH7xOVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfHTWM2OD1yLkK5NVQh|ryP NH7hT3lUSU6JRWK=
CAL-120 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXkeVQ1UUN3ME2wMlI6PjNzIN88US=> MWDTRW5ITVJ?
UACC-62 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXzSlhKSzVyPUCuN|AzPDFizszN M1zzWHNCVkeHUh?=
TE-11 M2nLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fUUmlEPTB;MD6zNFI1QSEQvF2= MXrTRW5ITVJ?
MKN1 M2f5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\ySVdKSzVyPUCuN|A{PiEQvF2= M37NbnNCVkeHUh?=
KS-1 NFTZbHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:xTWM2OD1yLkOwOVI3KM7:TR?= MojSV2FPT0WU
GCIY MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml6xTWM2OD1yLkOxNFAzKM7:TR?= MmToV2FPT0WU
OVCAR-5 NXvyNItJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwM{GxNFYh|ryP MmPSV2FPT0WU
U-266 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\MTWM2OD1yLkOxNVQ4KM7:TR?= MVHTRW5ITVJ?
Calu-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXIZVRMUUN3ME2wMlMyOjh7IN88US=> NWey[o93W0GQR1XS
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COLO-741 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwM{G2NVQh|ryP M{TOfHNCVkeHUh?=
RPMI-8226 NV\NeGVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnKTWM2OD1yLkOxOlQyKM7:TR?= NVrm[Y56W0GQR1XS
KM12 M3m1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\wVJVKSzVyPUCuN|E5OyEQvF2= NVXuNXN6W0GQR1XS
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SJRH30 NH;YOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HHR2lEPTB;MD6zNlA2OiEQvF2= NGGzOZhUSU6JRWK=
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TE-12 NXHBZWFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf2fJA3UUN3ME2wMlM{OzF5IN88US=> NVi2XnZwW0GQR1XS
KG-1 NEHZbGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwM{O0N|Ih|ryP MoHYV2FPT0WU
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EW-24 MknYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz3TWM2OD1yLkOzPVg1KM7:TR?= NGLT[ZpUSU6JRWK=
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NCI-H2405 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q3[GlEPTB;MD6zOFc{OiEQvF2= Mn\tV2FPT0WU
NCI-H2009 M1m5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\WO2VKSzVyPUCuN|Q4OzlizszN NV;VWHdDW0GQR1XS
LB1047-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXhVWRsUUN3ME2wMlM2QDF3IN88US=> NIfnUotUSU6JRWK=
KNS-81-FD MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXDXI9mUUN3ME2wMlM3PjZ5IN88US=> MV;TRW5ITVJ?
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L-428 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLTPJdFUUN3ME2wMlM4ODF4IN88US=> NUDET|BtW0GQR1XS
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SW954 NV31dmdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLaTWM2OD1yLkSwN|M2KM7:TR?= M3rD[XNCVkeHUh?=
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NCI-H1734 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwNEKwNVMh|ryP M2PXdXNCVkeHUh?=
HDLM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKwUYlEUUN3ME2wMlQzODN|IN88US=> NYHufZBOW0GQR1XS
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CAMA-1 NHnsVINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLubIxFUUN3ME2wMlQ{PjJ4IN88US=> NWfoUIxIW0GQR1XS
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LB831-BLC M1fscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwNESzO|Eh|ryP M{fIVnNCVkeHUh?=
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BFTC-909 M3THVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzHdXAzUUN3ME2wMlQ2Ojl7IN88US=> MVnTRW5ITVJ?
MEG-01 NWTHNGZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVL2VIVEUUN3ME2wMlQ2Ozd|IN88US=> MoHIV2FPT0WU
M14 M{K5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fEPWlEPTB;MD60OVk4QSEQvF2= MlntV2FPT0WU
MPP-89 NETmem5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTSR4hPUUN3ME2wMlQ3OjV4IN88US=> M3fFT3NCVkeHUh?=
HCC1937 NEDNTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnvd5VKSzVyPUCuOFY{QDRizszN NHjlcFVUSU6JRWK=
SW837 NYrBPWtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LXfWlEPTB;MD60OlczOiEQvF2= NWHXfldtW0GQR1XS
DU-145 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXEW2pyUUN3ME2wMlQ3PzJ7IN88US=> MYLTRW5ITVJ?
LB996-RCC M3nReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELTZWJKSzVyPUCuOFcxPTRizszN M1fWfXNCVkeHUh?=
C8166 NYPHOHN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\SVWlEPTB;MD60O|Qh|ryP M1n4NnNCVkeHUh?=
MOLT-4 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNEe3N|Qh|ryP NXPIe4dxW0GQR1XS
DMS-53 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnYTWM2OD1yLkS3PFA6KM7:TR?= NYrZdmw2W0GQR1XS
TE-5 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrSTFF{UUN3ME2wMlQ5OzB3IN88US=> NUDqNZhHW0GQR1XS
KYSE-520 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwNEizOFMh|ryP M{LmWnNCVkeHUh?=
Detroit562 MnrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n6dWlEPTB;MD60PFg3KM7:TR?= M3:zdnNCVkeHUh?=
SIMA MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXqTWM2OD1yLkS5OFE4KM7:TR?= NXfXUWJTW0GQR1XS
NCI-H1651 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HYXmlEPTB;MD60PVY4KM7:TR?= NGiyfYRUSU6JRWK=
HCC1599 NFfyeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnRTWM2OD1yLkS5PVU2KM7:TR?= MmLrV2FPT0WU
ABC-1 NUjNTFZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG0c5NTUUN3ME2wMlUxPDl4IN88US=> M1m4PHNCVkeHUh?=
CAL-33 NHHGbGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD4TWM2OD1yLkWwPFQ1KM7:TR?= NGOxc2xUSU6JRWK=
OPM-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHReYF6UUN3ME2wMlUxQTN5IN88US=> NWqyW5g2W0GQR1XS
RPMI-7951 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf3PJFKSzVyPUCuOVA6PTdizszN M4PhPHNCVkeHUh?=
HT-1080 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojITWM2OD1yLkWxNVE6KM7:TR?= NHzIZYxUSU6JRWK=
LC4-1 Mo\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNUG0NFMh|ryP MkjqV2FPT0WU
OVCAR-3 NFLSTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGxdpNkUUN3ME2wMlUyPTdizszN M2nwW3NCVkeHUh?=
CAPAN-1 M3vuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fGOmlEPTB;MD61NlI5QCEQvF2= M336dHNCVkeHUh?=
SK-OV-3 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTsTWM2OD1yLkWyOFM1KM7:TR?= M3HvZnNCVkeHUh?=
HuP-T3 NXzHO4NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwNUK4Nlch|ryP MVfTRW5ITVJ?
NCI-H838 NV7UdFBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjSfIlKSzVyPUCuOVI5PDlizszN NG\0OItUSU6JRWK=
K5 NXPx[ot6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfMTWM2OD1yLkWzNlAyKM7:TR?= NVnFTGNmW0GQR1XS
CAL-72 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwNUOzPFch|ryP MYPTRW5ITVJ?
NH-12 M3:xO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2naemlEPTB;MD61N|k2QSEQvF2= NI\rVnpUSU6JRWK=
SNB75 NVXwelc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzE[2hnUUN3ME2wMlU2PzNizszN NETNcpNUSU6JRWK=
BPH-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNU[zOFQh|ryP NX;sV4w{W0GQR1XS
NOMO-1 M2m3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnrVI5KSzVyPUCuOVY{PzJizszN MYDTRW5ITVJ?
G-402 M4\pdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTGd25KSzVyPUCuOVY1QTlizszN NIn5RXdUSU6JRWK=
NCI-H2052 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrPWooxUUN3ME2wMlU3PzRzIN88US=> Mnv3V2FPT0WU
RCM-1 NWTaVHlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwNUexOlYh|ryP M4XrZnNCVkeHUh?=
COR-L279 NUPrNWJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW3TWM2OD1yLkW3NVg2KM7:TR?= Mly5V2FPT0WU
A253 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXoTWM2OD1yLkW3OVI2KM7:TR?= M37zWHNCVkeHUh?=
SK-MM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwNUe2O|kh|ryP MWjTRW5ITVJ?
NCI-H1703 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\wT4VyUUN3ME2wMlU6PDJ5IN88US=> NEXhb4ZUSU6JRWK=
UACC-257 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHNflBKSzVyPUCuOVk1QDdizszN MYTTRW5ITVJ?
KALS-1 NGT4Om1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwNkCwNVEh|ryP M{XKZnNCVkeHUh?=
ES5 M4SwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjsdVFbUUN3ME2wMlYxPDhizszN MXzTRW5ITVJ?
MHH-CALL-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXlTWM2OD1yLk[wPFg5KM7:TR?= NX[xdmZbW0GQR1XS
ChaGo-K-1 NX;GfJRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwNkGyNlkh|ryP NGLSVnJUSU6JRWK=
TGBC1TKB MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNkG5PEDPxE1? NULHVJJwW0GQR1XS
KU-19-19 M2ToXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPVWHVKSzVyPUCuOlQ2QDZizszN NVfzR4VNW0GQR1XS
COLO-684 NVHVTFZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfITWM2OD1yLk[1OlEyKM7:TR?= MlnnV2FPT0WU
LS-1034 MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNkW4NVkh|ryP NHfVWVRUSU6JRWK=
RT-112 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjBSFVKSzVyPUCuOlY2QDdizszN NXPUR5NtW0GQR1XS
Capan-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTpUXg5UUN3ME2wMlY3PjJ{IN88US=> NIS2[ZNUSU6JRWK=
HSC-4 M1rnOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvlcmlOUUN3ME2wMlY3Pjl6IN88US=> NGPqOJhUSU6JRWK=
COLO-824 M1XKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;LTWM2OD1yLk[3PFI{KM7:TR?= NYG2c|VGW0GQR1XS
NCI-H2170 NFLmeJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPCW2p6UUN3ME2wMlY5OjV6IN88US=> M{T6fnNCVkeHUh?=
GDM-1 NYrhWVg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG5THdOUUN3ME2wMlY5PDl2IN88US=> M3u5NXNCVkeHUh?=
KP-4 M1eyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwNkm1O|Mh|ryP MYTTRW5ITVJ?
VA-ES-BJ MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7LW5BKSzVyPUCuOlk6QDZizszN MlXJV2FPT0WU
KM-H2 NELoS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwN{CwPVEh|ryP Mn76V2FPT0WU
HH NYLKbGVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHJTWM2OD1yLkewOlYzKM7:TR?= MV7TRW5ITVJ?
DK-MG NEfUO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwN{GwNVYh|ryP MkHCV2FPT0WU
VM-CUB-1 M3LVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUe1dYtWUUN3ME2wMlcyOjV7IN88US=> NV\GPHpKW0GQR1XS
COLO-829 NUnle213T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPJV5EzUUN3ME2wMlcyQTh3IN88US=> MX7TRW5ITVJ?
OMC-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwN{KxNFQh|ryP M1G3UHNCVkeHUh?=
NB12 M{nu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnPfmdKSzVyPUCuO|I2ODRizszN Ml3CV2FPT0WU
NCI-H28 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\o[4dqUUN3ME2wMlc1ODh|IN88US=> MnvHV2FPT0WU
A673 NXLpdoM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33SdWlEPTB;MD63OVE4PyEQvF2= M4T0eXNCVkeHUh?=
LB2241-RCC M4[zZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vscGlEPTB;MD63OlA5PyEQvF2= M4T3dHNCVkeHUh?=
CCRF-CEM MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fBXWlEPTB;MD63O|A2OiEQvF2= M1fuW3NCVkeHUh?=
NCI-H510A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zo[2lEPTB;MD63O|E5PiEQvF2= NYG0fIlEW0GQR1XS
SW48 M4DLe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrhTWM2OD1yLke3N|M{KM7:TR?= M2C5R3NCVkeHUh?=
NCI-H2081 NW\EOmh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwN{ixOFch|ryP MXLTRW5ITVJ?
RMG-I MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwN{iyNVIh|ryP MVHTRW5ITVJ?
LU-99A M1SzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e3bGlEPTB;MD63PFQyOyEQvF2= MnjlV2FPT0WU
KP-N-YS MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\QTWM2OD1yLke4PVIyKM7:TR?= NHK2dZNUSU6JRWK=
MDA-MB-231 M3\3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVraWYQ3UUN3ME2wMlgxOTNzIN88US=> MU\TRW5ITVJ?
U031 M4rBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3BZo9{UUN3ME2wMlgyPDJ|IN88US=> MUnTRW5ITVJ?
EVSA-T NGXrVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwOEG2O|Ih|ryP M320PXNCVkeHUh?=
MDA-MB-157 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rlWmlEPTB;MD64NlI4OSEQvF2= MXLTRW5ITVJ?
EHEB NHLxPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\HTWM2OD1yLkiyNlc3KM7:TR?= NGfOeXFUSU6JRWK=
KINGS-1 M{nubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwOEK1OVUh|ryP MXzTRW5ITVJ?
23132-87 M1fkUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfDdnVKSzVyPUCuPFI5PDNizszN M3vzVXNCVkeHUh?=
EFO-21 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnrTWM2OD1yLki0NFg6KM7:TR?= MmrsV2FPT0WU
DOK Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOwTWM2OD1yLki0PEDPxE1? Mn3tV2FPT0WU
NCI-H2171 MlG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwOES5OkDPxE1? NVzCNo1uW0GQR1XS
NCI-SNU-5 M2XuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHoeW9sUUN3ME2wMlg2PTdizszN NVzzTm51W0GQR1XS
SK-N-DZ NEnjNWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjSTWM2OD1yLki1PVQ{KM7:TR?= NHzFdoxUSU6JRWK=
SNU-C2B Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r0UmlEPTB;MD64OlgxOSEQvF2= MVvTRW5ITVJ?
CP66-MEL M{HU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;VRnNsUUN3ME2wMlg4OTFizszN MkDzV2FPT0WU
SN12C Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LIbGlEPTB;MD64PFY{PyEQvF2= NWTQNGFNW0GQR1XS
A172 MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvxZXNKSzVyPUCuPFg3QThizszN MoLaV2FPT0WU
NCI-H2347 NWryOWFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HQdWlEPTB;MD64PFc2OyEQvF2= NHzQd5hUSU6JRWK=
NCI-H2228 Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwOEmzN|kh|ryP Mke1V2FPT0WU
SNU-387 M{LyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\rZmlEPTB;MD65NFI3PCEQvF2= NUnZWGJMW0GQR1XS
SK-MEL-24 M{WxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfidmdKSzVyPUCuPVE{PDRizszN NH\4OVZUSU6JRWK=
MDA-MB-468 M1XsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SwfWlEPTB;MD65NVc{KM7:TR?= NI\xdoVUSU6JRWK=
NCI-H1694 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T4WGlEPTB;MD65NVg4PiEQvF2= M4\PPXNCVkeHUh?=
CCF-STTG1 M4DPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjoTWM2OD1yLkmyOlM4KM7:TR?= MWPTRW5ITVJ?
K052 M4HRcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjlTWM2OD1yLkm0NFQ4KM7:TR?= MlPQV2FPT0WU
NCI-H446 NVL1O5lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELa[JFKSzVyPUCuPVUxOSEQvF2= M1\Z[HNCVkeHUh?=
MFE-280 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUeyXHE1UUN3ME2wMlk3OjlzIN88US=> M4\qcnNCVkeHUh?=
KU812 NFf2UGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH64e5RKSzVyPUCuPVk{QDlizszN NH;2S21USU6JRWK=
MDA-MB-361 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfUNpdKSzVyPUCuPVk4PzdizszN NX7xVYhoW0GQR1XS
Raji M{jLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXTTWM2OD1zLkCyNlY4KM7:TR?= NGTDO2JUSU6JRWK=
TE-6 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwMEO1OlYh|ryP M{XhXHNCVkeHUh?=
CAL-148 NY[0cY42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPuTZB3UUN3ME2xMlA1PDR|IN88US=> MYnTRW5ITVJ?
NCI-H1963 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DvVWlEPTB;MT6wOFU2OyEQvF2= MlLVV2FPT0WU
SK-N-AS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOOFFKSzVyPUGuNFQ3QDVizszN M4DUSXNCVkeHUh?=
RERF-LC-MS M1\YfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTFwME[zOFkh|ryP MWPTRW5ITVJ?
BEN MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvITWM2OD1zLkC3NVM4KM7:TR?= M4jRfnNCVkeHUh?=
CAS-1 NXTVdIt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDuZXVKSzVyPUGuNFkyOjNizszN MlHWV2FPT0WU
SW780 NXjqXpNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTFwMEmxPFEh|ryP MXzTRW5ITVJ?
LU-65 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwMEm0NUDPxE1? MmPIV2FPT0WU
D-283MED M1:zcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\4NGN5UUN3ME2xMlEzOjd{IN88US=> MYnTRW5ITVJ?
HCC2157 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrsTVlKSzVyPUGuNVM3PDJizszN M{P4W3NCVkeHUh?=
RCC10RGB M3HrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jUT2lEPTB;MT6xOFAxPiEQvF2= M4j2OHNCVkeHUh?=
PLC-PRF-5 NIH4epBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTCXpRtUUN3ME2xMlE2OjJ7IN88US=> MkniV2FPT0WU
H4 NYXRUm97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;ETWM2OD1zLkG1OFM6KM7:TR?= MmfPV2FPT0WU
TUR NWjPbZhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTFwMUW3OVIh|ryP NWP0TpRnW0GQR1XS
NCI-H2141 M3nNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH2TJJKSzVyPUGuNVg6PDZizszN NYH3XVdKW0GQR1XS
PFSK-1 M1n3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnJW2xKSzVyPUGuNlA2OzJizszN NGezS3FUSU6JRWK=
SK-MEL-28 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r5SmlEPTB;MT6yN|IzOSEQvF2= M1mxenNCVkeHUh?=
SCC-9 Mlj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFwMkO2OlUh|ryP MYrTRW5ITVJ?
T47D NVHDSZI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm4cWRnUUN3ME2xMlI{Pjl4IN88US=> MlHMV2FPT0WU
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KMS-12-PE NX:0ToRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu2TWM2OD13LkO1NFg2KM7:TR?= MXjTRW5ITVJ?
HCC1954 NGHLSItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvxTWM2OD13Lki1PVcyKM7:TR?= MnvpV2FPT0WU
NCI-H187 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX2RXdEUUN3ME21MlkzQTh7IN88US=> NWD0UGRPW0GQR1XS
LU-165 NVzGT5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPLTWM2OD13Lkm5NFAzKM7:TR?= Moj0V2FPT0WU
YAPC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2GxRWlEPTB;NT65PVA3QCEQvF2= MkPnV2FPT0WU
LU-139 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T5XmlEPTB;Nj6wPFM3QCEQvF2= MVjTRW5ITVJ?
D-502MG NI\ZfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3EcpBCUUN3ME22MlMzODR5IN88US=> M1m0PXNCVkeHUh?=
IST-SL1 NIHF[npIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTZwNUO5OFgh|ryP MlTrV2FPT0WU
DG-75 NXPEU2lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnYTWM2OD14Lki4O|g3KM7:TR?= NITVZnhUSU6JRWK=
NCI-H1155 M2PF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTZwOUW1PFEh|ryP M{K5PXNCVkeHUh?=
EFE-184 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPpTWM2OD15LkOxOlk2KM7:TR?= M3PIeXNCVkeHUh?=
AsPC-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf6WotKSzVyPUeuOFg5ODdizszN M3nES3NCVkeHUh?=
SW948 NGjLVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLF[JpKSzVyPUeuOVg{QTVizszN NIjCeldUSU6JRWK=
NCI-H524 MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTlwNUi2Nlgh|ryP M4\mNXNCVkeHUh?=
KOSC-2 M3Prbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;iZmlEPTB;OT62Nlg{PCEQvF2= MmDtV2FPT0WU
T-24 M2G1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTlwOUS0NVUh|ryP NFvjRnNUSU6JRWK=
NCI-H748 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTzZ4Q2UUN3ME2xNE43Ozl5IN88US=> MXHTRW5ITVJ?
NCI-H23 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLtWVBKSzVyPUGwMlY1PDJizszN M12yfHNCVkeHUh?=
UACC-812 M3WybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTKNpVKSzVyPUGxMlcyPyEQvF2= NF7o[FBUSU6JRWK=
SCLC-21H MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfjTWM2OD1zMj6xOVUyKM7:TR?= MVvTRW5ITVJ?
NCI-SNU-16 MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF|LkGyOVgh|ryP MXHTRW5ITVJ?
HD-MY-Z M1XmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDWb4tGUUN3ME2xOE43OzZ|IN88US=> MYDTRW5ITVJ?
SK-N-FI NVe0Z4U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLrSodwUUN3ME2xOE45QTF{IN88US=> M4rNbnNCVkeHUh?=
LB647-SCLC NFLPO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrPcWp5UUN3ME2xOU44OTl3IN88US=> M122[HNCVkeHUh?=
NCI-H345 NHP0XGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP4TWM2OD1zNz6zOFMh|ryP MoH4V2FPT0WU
NCI-H1563 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnWfWNKSzVyPUG4Mlc3ODFizszN NYXzSJpzW0GQR1XS
RL NHS4TGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\kTWM2OD1{MT6yOlU3KM7:TR?= Ml7HV2FPT0WU
KY821 NGHiZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Lsb2lEPTB;MkKuNFU2OyEQvF2= M2DFXXNCVkeHUh?=
JVM-3 NEHFXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDGcVByUUN3ME2yOU4xPDF|IN88US=> M4DyNHNCVkeHUh?=
NCI-H1793 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHmT|hKSzVyPUK4MlU1QTlizszN NWTQSFQ5W0GQR1XS
LU-134-A MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTNyLkKwN|ch|ryP MlLWV2FPT0WU
NCI-H1395 M1jtVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjyTWM2OD1|Mj6yOFMyKM7:TR?= NHXsSnVUSU6JRWK=
NCI-H1993 NUDCfHh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvXTWM2OD1|Mj64NlE5KM7:TR?= MoKxV2FPT0WU
P31-FUJ NXm4OXBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HUUWlEPTB;M{OuOFg6QSEQvF2= MX3TRW5ITVJ?
LS-513 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC4UYxmUUN3ME2zOU45QDd7IN88US=> NVXTNFNCW0GQR1XS
SK-MEL-1 Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfuTWM2OD12MD6zOFk6KM7:TR?= NFfnOHZUSU6JRWK=
SW684 M3jzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjWfWs1UUN3ME20N{46PjZzIN88US=> NV33dGNMW0GQR1XS
COR-L88 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzCUYVKSzVyPUS0MlA3PjVizszN NH7MWmVUSU6JRWK=
NCI-H889 MlrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfaTWM2OD12NT6wNFg4KM7:TR?= MoG3V2FPT0WU
TALL-1 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnSN28yUUN3ME20Ok4yOTl7IN88US=> MXXTRW5ITVJ?
KARPAS-299 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nwfWlEPTB;NEeuNVk6OyEQvF2= MkTmV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin D1 / p27 Kip1 ; 

PubMed: 28382170     


Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1.

p-Cyclin D1 ; 

PubMed: 28035994     


Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control;

p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; 

PubMed: 28035994     


Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;

28382170 28035994
Growth inhibition assay
Cell proliferation ; 

PubMed: 28035994     


Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control.

Cell viability; 

PubMed: 21368880     


H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D. 

28035994 21368880
In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
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Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
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  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID