Obatoclax Mesylate (GX15-070)

For research use only.

Catalog No.S1057

74 publications

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Selleck's Obatoclax Mesylate (GX15-070) has been cited by 74 publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 NFqydI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMECwNFMyPyEQvF2= M3LCW3NCVkeHUh?=
SK-MEL-30 NGXkOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HMZmlEPTB;MD6wNFA{PTVizszN MlrDV2FPT0WU
NALM-6 NYTle3pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMECwN|U3KM7:TR?= NEnHNIxUSU6JRWK=
KYSE-450 NHrGfVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1O0eWlEPTB;MD6wNFA1PjlizszN NH7se2lUSU6JRWK=
BHY M4mxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HKc2lEPTB;MD6wNFA3ODFizszN NEftNVNUSU6JRWK=
GR-ST MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTzc5hDUUN3ME2wMlAxODZ2ODFOwG0> NEDpNVNUSU6JRWK=
786-0 M1HZUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMECwO|c3KM7:TR?= M12zWnNCVkeHUh?=
C-33-A MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfsbnhKSzVyPUCuNFAxQDR6IN88US=> MVHTRW5ITVJ?
BHT-101 NUfkT5czT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfGPY9RUUN3ME2wMlAxOTB4IN88US=> MYrTRW5ITVJ?
EB2 NEnIOnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH20cIdKSzVyPUCuNFAyOThizszN M1zGfXNCVkeHUh?=
G-361 Mn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\1VWlEPTB;MD6wNFEzPCEQvF2= MlPOV2FPT0WU
KE-37 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLEXFBKSzVyPUCuNFAyOjhizszN NF\2OHpUSU6JRWK=
MHH-PREB-1 M4q1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUH1eZV{UUN3ME2wMlAxOTRizszN NWDNNnpKW0GQR1XS
MCF7 NEPQXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\UVoRwUUN3ME2wMlAxOTV7IN88US=> NFjse3JUSU6JRWK=
LOUCY Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWG2cHdrUUN3ME2wMlAxOTd3IN88US=> NFi0NmpUSU6JRWK=
EW-7 NIDKdpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMECxO|Uh|ryP M2TXb3NCVkeHUh?=
KYSE-510 M4PVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMECyN|Mh|ryP NE\yU|hUSU6JRWK=
SK-MEL-3 NXiwb5pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfrTWM2OD1yLkCwNlY1KM7:TR?= M{L1XnNCVkeHUh?=
HAL-01 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMECyPVch|ryP MXrTRW5ITVJ?
HCC2998 M3fuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMECzN|Uh|ryP MV;TRW5ITVJ?
A375 M2DjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUflTWc5UUN3ME2wMlAxOzVizszN NHLsUFZUSU6JRWK=
MZ7-mel NGTQSGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Kx[2lEPTB;MD6wNFM6QSEQvF2= MY\TRW5ITVJ?
SH-4 M1fkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi3NWNUUUN3ME2wMlAxPDF5IN88US=> NGPyWZhUSU6JRWK=
HT-144 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PaSWlEPTB;MD6wNFQ{KM7:TR?= NH;FNlJUSU6JRWK=
KYSE-140 NIrXZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKzTWM2OD1yLkCwOFM2KM7:TR?= NIXIfWVUSU6JRWK=
PSN1 NHnYOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LtNGlEPTB;MD6wNFQ3PyEQvF2= NGjsXGdUSU6JRWK=
COLO-679 NILneFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXtfGFKSzVyPUCuNFA1QThizszN NFKxcFBUSU6JRWK=
SW620 NGPR[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknuTWM2OD1yLkCwOVEyKM7:TR?= Ml7hV2FPT0WU
HGC-27 NVTFdm1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIS0dm9KSzVyPUCuNFA2OjRizszN MWTTRW5ITVJ?
IGROV-1 NHToOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjHR3FrUUN3ME2wMlAxPiEQvF2= NVfPTpp5W0GQR1XS
IGR-1 NIj5U2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEC2NFEh|ryP MWjTRW5ITVJ?
EW-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\TTWM2OD1yLkCwOlUyKM7:TR?= NGLQdVFUSU6JRWK=
769-P MknZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:2d2NKSzVyPUCuNFA3PzhizszN M1\TSHNCVkeHUh?=
HN NFTkfnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jzOGlEPTB;MD6wNFY4QSEQvF2= NWTzWHR1W0GQR1XS
SIG-M5 NGjwWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILZc45KSzVyPUCuNFA4OSEQvF2= MVnTRW5ITVJ?
IST-MEL1 NYjMZlByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzRfJVKSzVyPUCuNFA5OThizszN MWXTRW5ITVJ?
ST486 NYDXcHZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDDXHZ6UUN3ME2wMlAxQDJ3IN88US=> NXXwXmNSW0GQR1XS
ES7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPkNI9KSzVyPUCuNFA5PDZizszN NUjxUmFXW0GQR1XS
GAK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnPXWFKSzVyPUCuNFA5PDhizszN NGP1eXVUSU6JRWK=
BB30-HNC M4PTVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\xPWlEPTB;MD6wNFg2QCEQvF2= MYHTRW5ITVJ?
IPC-298 NUXMV|BsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzacWxKSzVyPUCuNFA6OjdizszN M4LQVHNCVkeHUh?=
NKM-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X6emlEPTB;MD6wNFk4OiEQvF2= MkjBV2FPT0WU
RKO MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32zbmlEPTB;MD6wNVA1PCEQvF2= MknSV2FPT0WU
ACN MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfx[XIzUUN3ME2wMlAyOTNzIN88US=> M1ywd3NCVkeHUh?=
SW1417 NYfPVmR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmzS4FKSzVyPUCuNFEzOjVizszN NGfPPFBUSU6JRWK=
SR NFj1dY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnZR3pKSzVyPUCuNFEzOzVizszN NEK0N3BUSU6JRWK=
SNG-M NHnY[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLWTXJEUUN3ME2wMlAyOzF5IN88US=> M1zvd3NCVkeHUh?=
CAL-12T MkTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zaOGlEPTB;MD6wNVM1PiEQvF2= M2ntdHNCVkeHUh?=
HSC-3 MkDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHmemo4UUN3ME2wMlAyOzV3IN88US=> MYTTRW5ITVJ?
DOHH-2 Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXOfow1UUN3ME2wMlAyPDF{IN88US=> M3XEVHNCVkeHUh?=
NB69 NXfCTnRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;zTWM2OD1yLkCxOVY2KM7:TR?= M2DUbXNCVkeHUh?=
LC-2-ad MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;DTWM2OD1yLkCxOVgyKM7:TR?= MVHTRW5ITVJ?
RVH-421 NFLjRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{SzeGlEPTB;MD6wNVY4PCEQvF2= MWTTRW5ITVJ?
TGW NEPxOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjOW4dKSzVyPUCuNFE4OzlizszN MlvGV2FPT0WU
HCC1569 M4jPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r0WGlEPTB;MD6wNVc6PyEQvF2= NGLucHFUSU6JRWK=
CAL-85-1 NWThbHZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nueWlEPTB;MD6wNVg{OiEQvF2= MmjnV2FPT0WU
RPMI-8402 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLOfFdKSzVyPUCuNFE5PThizszN NYDydm84W0GQR1XS
THP-1 M4rIS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f3[mlEPTB;MD6wNVk6QCEQvF2= MmL3V2FPT0WU
ONS-76 M4PaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXryPJg4UUN3ME2wMlAzODN4IN88US=> Ml6xV2FPT0WU
A2780 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[2TWM2OD1yLkCyNFc6KM7:TR?= NXjF[HA3W0GQR1XS
RPMI-2650 M{LuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7EUVhbUUN3ME2wMlAzOjl4IN88US=> MVLTRW5ITVJ?
MEL-HO NIC3U3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTBwMEKzOFgh|ryP M1vRT3NCVkeHUh?=
MC-CAR NFnMO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;DcpFKSzVyPUCuNFI{PTZizszN M2f5U3NCVkeHUh?=
HSC-2 NWPtZ3MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXVVGZKSzVyPUCuNFI1PjZizszN M3j4R3NCVkeHUh?=
MEL-JUSO MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTmd4JpUUN3ME2wMlAzPDd|IN88US=> MYrTRW5ITVJ?
CAL-62 NUfFeIQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33KXmlEPTB;MD6wNlYxOiEQvF2= MkDZV2FPT0WU
DMS-273 M3e4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\PTWM2OD1yLkCyPFQ4KM7:TR?= NIe2UWVUSU6JRWK=
S-117 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEK5NFYh|ryP M1jaeHNCVkeHUh?=
SUP-T1 NGPpV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEK5OFkh|ryP MXzTRW5ITVJ?
MZ2-MEL Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\RTWM2OD1yLkCyPVU6KM7:TR?= MYnTRW5ITVJ?
KYSE-270 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP5Z4tKSzVyPUCuNFI6PzZizszN NIfLRVdUSU6JRWK=
CMK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLwTWM2OD1yLkCzNFI{KM7:TR?= M4[5c3NCVkeHUh?=
8505C NIPLZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEOwOEDPxE1? MX\TRW5ITVJ?
NUGC-3 NX7WT|MxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrmbYZbUUN3ME2wMlA{ODR6IN88US=> MVHTRW5ITVJ?
A101D MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHqTWM2OD1yLkCzNFU2KM7:TR?= MUXTRW5ITVJ?
G-401 NUHINYpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf0TWM2OD1yLkCzNFk{KM7:TR?= M2HXbnNCVkeHUh?=
OVCAR-8 NYLhTpFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEOxNFch|ryP MX\TRW5ITVJ?
IMR-5 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPUcFRPUUN3ME2wMlA{OjR2IN88US=> M1i1[nNCVkeHUh?=
DoTc2-4510 NU[1R3I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPxTWM2OD1yLkCzN|k{KM7:TR?= NYLLd2JmW0GQR1XS
HOS M1HBOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMEO0O|Mh|ryP NELzcWlUSU6JRWK=
HEC-1 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEO2PEDPxE1? NFLXVVFUSU6JRWK=
SW756 NH[xO4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMEO4NlEh|ryP MkDxV2FPT0WU
NCI-H64 M4nkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\QNmlEPTB;MD6wN|g1OiEQvF2= M{XLR3NCVkeHUh?=
EW-16 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETRdZdKSzVyPUCuNFM6ODlizszN M4DVSnNCVkeHUh?=
CAL-51 NGq0XYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DqVWlEPTB;MD6wOFAxPSEQvF2= NV\JTWhmW0GQR1XS
KYSE-150 M4jV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMESwNVEh|ryP NX2ycVZqW0GQR1XS
SW1710 NUjQcVc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi1cYNKSzVyPUCuNFQxOThizszN M1zlVXNCVkeHUh?=
HuP-T4 M37rUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV2yeW1FUUN3ME2wMlA1OTF6IN88US=> M2ryN3NCVkeHUh?=
LB373-MEL-D MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP4dZNKSzVyPUCuNFQzOzJizszN NX3abnBvW0GQR1XS
EW-13 M4\UTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDLSllKSzVyPUCuNFQ1ODZizszN MkHWV2FPT0WU
HT-29 NIGxWWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnkfoRKSzVyPUCuNFQ1QSEQvF2= MVnTRW5ITVJ?
SCC-25 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPQTWM2OD1yLkC0OFk1KM7:TR?= M1X6[3NCVkeHUh?=
REH MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XrZmlEPTB;MD6wOFY{PSEQvF2= MXnTRW5ITVJ?
L-363 NWfpS2dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPqTWM2OD1yLkC0Olc6KM7:TR?= MmnNV2FPT0WU
NCI-H1770 M3jU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHjTWM2OD1yLkC0Olk4KM7:TR?= MkPMV2FPT0WU
CHL-1 M2\vRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMES4OVch|ryP MYTTRW5ITVJ?
ES1 M{jVXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMES4PFUh|ryP MX3TRW5ITVJ?
SCC-15 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zNcGlEPTB;MD6wOFkxOiEQvF2= MV3TRW5ITVJ?
MRK-nu-1 M{C2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LTbGlEPTB;MD6wOFk{PiEQvF2= Mn3CV2FPT0WU
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HMV-II M37mbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoKwTWM2OD1yLkC1NlM6KM7:TR?= M{PI[HNCVkeHUh?=
PC-14 NF3RNI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;jZYhKSzVyPUCuNFUzPTJizszN MVvTRW5ITVJ?
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LCLC-97TM1 M13GTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEW1PVQh|ryP MY\TRW5ITVJ?
Daoy NYntXotrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvzTWM2OD1yLkC1OlE3KM7:TR?= NFr2ZmlUSU6JRWK=
ETK-1 MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVm3[nQ3UUN3ME2wMlA2Pjd{IN88US=> NF3ifmhUSU6JRWK=
A388 NHH5TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPPSZd4UUN3ME2wMlA2Pjl3IN88US=> M{juWnNCVkeHUh?=
COLO-205 Ml7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrpVoNyUUN3ME2wMlA2PzF4IN88US=> MW\TRW5ITVJ?
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EB-3 NVz6dFg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXCfGtKUUN3ME2wMlE4OzFizszN Moq2V2FPT0WU
HCC1143 MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LwcmlEPTB;MD6xO|M6PiEQvF2= MXTTRW5ITVJ?
DJM-1 MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PjZ2lEPTB;MD6xO|Q2OSEQvF2= NVrWXoJIW0GQR1XS
BT-474 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvTeGNKSzVyPUCuNVc1QDlizszN MU\TRW5ITVJ?
BB65-RCC MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnzTWM2OD1yLkG3OVQ2KM7:TR?= MXvTRW5ITVJ?
NCI-H292 MlvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwMUe2NFEh|ryP NHnJS2ZUSU6JRWK=
MKN28 M3zCbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\NcYlKSzVyPUCuNVc3PTNizszN NHHLTYlUSU6JRWK=
TK10 M2\wdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnLTWM2OD1yLkG3O|AzKM7:TR?= NV7SUnFwW0GQR1XS
TYK-nu NUGzPJFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P4PGlEPTB;MD6xO|k1QSEQvF2= NGDiOotUSU6JRWK=
8305C MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml:2TWM2OD1yLkG3PVcyKM7:TR?= M4Ds[HNCVkeHUh?=
MV-4-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjsTWM2OD1yLkG3PVc4KM7:TR?= MoTvV2FPT0WU
NCI-H522 M4K4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMUiwPVQh|ryP MmP0V2FPT0WU
Hs-578-T NYHTO41IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\pTWM2OD1yLkG4NlkzKM7:TR?= NV:5PYxZW0GQR1XS
LCLC-103H M1z1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPOTWM2OD1yLkG4OVI4KM7:TR?= NWXxPZh3W0GQR1XS
MHH-ES-1 M1P4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33oVmlEPTB;MD6xPFYzQSEQvF2= Mk\CV2FPT0WU
NCI-H441 M{DnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrQZWRKSzVyPUCuNVkyPDhizszN NXLRWXhxW0GQR1XS
AM-38 M{PqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PNVmlEPTB;MD6xPVIzPSEQvF2= MXzTRW5ITVJ?
SW1783 M1jUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMUmzNFUh|ryP NGnVeXpUSU6JRWK=
SK-HEP-1 M{LvbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMUm2N|ch|ryP NGjDWItUSU6JRWK=
OAW-28 NIjNeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrD[I1yUUN3ME2wMlIxOTd6IN88US=> MV3TRW5ITVJ?
TE-15 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7DZXlKUUN3ME2wMlIxOjV{IN88US=> NFO4VYtUSU6JRWK=
HCE-4 NHjXdoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTMbJBKSzVyPUCuNlAzQDRizszN M1iwNXNCVkeHUh?=
JiyoyeP-2003 NWDCXYxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTSSGhKSzVyPUCuNlA{OzZizszN MorwV2FPT0WU
OVCAR-4 NFzUfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;HeJBKSzVyPUCuNlA3OjhizszN MmfxV2FPT0WU
SNU-449 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzVTlZKSzVyPUCuNlA4QTdizszN MV\TRW5ITVJ?
SBC-5 Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z0SGlEPTB;MD6yNVIyPSEQvF2= Mk\3V2FPT0WU
T84 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j1VmlEPTB;MD6yNVI1QCEQvF2= MWfTRW5ITVJ?
LP-1 NXPpVmdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTNeHJIUUN3ME2wMlIyOzB{IN88US=> MXTTRW5ITVJ?
MG-63 NXH1RXhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jDWGlEPTB;MD6yNVM5OiEQvF2= MnzLV2FPT0WU
OAW-42 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMkG0O|gh|ryP MWrTRW5ITVJ?
L-540 NG\hc3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TjZ2lEPTB;MD6yNVU6QCEQvF2= MoC2V2FPT0WU
RH-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHyTWM2OD1yLkKyNlQzKM7:TR?= MXnTRW5ITVJ?
HCT-15 Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELUXFBKSzVyPUCuNlI1QDRizszN MV\TRW5ITVJ?
OCUB-M MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMkK0PFgh|ryP M4TKU3NCVkeHUh?=
GP5d Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ETWM2OD1yLkKyOVI5KM7:TR?= Mn\pV2FPT0WU
NCI-H2030 M4e4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMkK3N|Qh|ryP MmPzV2FPT0WU
ML-2 MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HZbWlEPTB;MD6yNlg5QSEQvF2= NVXUXI83W0GQR1XS
CAL-39 NVnXR3FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXWUYw1UUN3ME2wMlIzQTN4IN88US=> NHTXXmZUSU6JRWK=
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LB2518-MEL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC1TWM2OD1yLkKzN|czKM7:TR?= NWHNTWhNW0GQR1XS
DB M1n1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMkO0N|gh|ryP M1jkb3NCVkeHUh?=
NCI-H596 M1vMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMkO1O|Eh|ryP MYDTRW5ITVJ?
SW1990 NIPRV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r2bWlEPTB;MD6yN|k1PiEQvF2= NW\TPGY{W0GQR1XS
P30-OHK MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrkbnUxUUN3ME2wMlI1ODVizszN MkHsV2FPT0WU
ALL-PO M4n3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGH4PYdKSzVyPUCuNlQyPjlizszN NFm4WnFUSU6JRWK=
Saos-2 NVe3VnVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnl[G9FUUN3ME2wMlI1PTdzIN88US=> M33uPHNCVkeHUh?=
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OE33 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMkWxNUDPxE1? MlXVV2FPT0WU
Calu-3 NGK3VJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;WTWM2OD1yLkK1Nlk4KM7:TR?= NHeyUIxUSU6JRWK=
HT NYja[VBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMkW2NlEh|ryP NHHiUFhUSU6JRWK=
LXF-289 M3H4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\2d4RKSzVyPUCuNlU6QDRizszN M2XwbXNCVkeHUh?=
KGN NWTGZm9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXPVoFDUUN3ME2wMlI3ODh7IN88US=> NIX3eGlUSU6JRWK=
NCI-H1417 M4OzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHUb4J2UUN3ME2wMlI3PTJ2IN88US=> MYXTRW5ITVJ?
SF126 MnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMkezNFIh|ryP NHfLZ3hUSU6JRWK=
SAS NWrrfIhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfTTWM2OD1yLkK3N|A5KM7:TR?= NIL6R|hUSU6JRWK=
22RV1 M1PIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7Pe|VkUUN3ME2wMlI4Ozd6IN88US=> NWLJSWVXW0GQR1XS
GI-1 NUj2PYhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjudFZKSzVyPUCuNlc1QDdizszN NULCU2ZuW0GQR1XS
ES3 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mle1TWM2OD1yLkK3O|Y{KM7:TR?= NHPySohUSU6JRWK=
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NCI-H650 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLleFltUUN3ME2wMlI5OzB{IN88US=> M1f1UXNCVkeHUh?=
IST-MES1 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHCWXVKSzVyPUCuNlg2PTRizszN M3TEVHNCVkeHUh?=
UM-UC-3 NEH4W45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvp[WJKSzVyPUCuNlkyPCEQvF2= NI\TWpFUSU6JRWK=
CAL-120 NIm0boVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHiTWM2OD1yLkK5OlMyKM7:TR?= MoLOV2FPT0WU
UACC-62 M{X3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjPXnVKSzVyPUCuN|AzPDFizszN M4W5PHNCVkeHUh?=
TE-11 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ETWM2OD1yLkOwNlQ6KM7:TR?= M{fVNHNCVkeHUh?=
MKN1 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwM{CzOkDPxE1? NEn0Um1USU6JRWK=
KS-1 NU\BZmNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVGzeIM4UUN3ME2wMlMxPTJ4IN88US=> M{\1fHNCVkeHUh?=
GCIY NY\LO29vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwM{GwNFIh|ryP NEOxOmhUSU6JRWK=
OVCAR-5 M2jocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ewZ2lEPTB;MD6zNVExPiEQvF2= Mn76V2FPT0WU
U-266 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PVRmlEPTB;MD6zNVE1PyEQvF2= M4TQWnNCVkeHUh?=
Calu-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH2TWM2OD1yLkOxNlg6KM7:TR?= M3XmeHNCVkeHUh?=
SK-LMS-1 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M330UmlEPTB;MD6zNVQzQSEQvF2= MnPlV2FPT0WU
COLO-741 NIT0TpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwM{G2NVQh|ryP MknjV2FPT0WU
RPMI-8226 M{Lx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\mTWM2OD1yLkOxOlQyKM7:TR?= M3TDO3NCVkeHUh?=
KM12 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwM{G4N{DPxE1? MX\TRW5ITVJ?
NMC-G1 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG3TWM2OD1yLkOxPFYh|ryP MnjvV2FPT0WU
SJRH30 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfNfYVKSzVyPUCuN|IxPTJizszN Mnf3V2FPT0WU
COR-L105 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XJT2lEPTB;MD6zNlIyQCEQvF2= NH7JZ5FUSU6JRWK=
IM-9 NETrZ2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXFOZdKSzVyPUCuN|MxOjFizszN NYLoZlZnW0GQR1XS
TE-12 NXvtSopzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwM{OzNVch|ryP MULTRW5ITVJ?
KG-1 M2P2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwM{O0N|Ih|ryP MlzEV2FPT0WU
U251 NUHWepp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S4dGlEPTB;MD6zN|Q2PiEQvF2= MlHCV2FPT0WU
EFO-27 NYjXTZVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP4U5FiUUN3ME2wMlM{QTVzIN88US=> NX7KZYY6W0GQR1XS
EW-24 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu5[ZBKSzVyPUCuN|M6QDRizszN NWLxbI91W0GQR1XS
SF295 MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqwTWM2OD1yLkOzPVk6KM7:TR?= MkTBV2FPT0WU
MC-IXC MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwM{S1JO69VQ>? Ml73V2FPT0WU
NCI-H2405 NX7TfIs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\KTWM2OD1yLkO0O|MzKM7:TR?= MlXxV2FPT0WU
NCI-H2009 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwM{S3N|kh|ryP MonFV2FPT0WU
LB1047-RCC NUP0SWV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXSTWM2OD1yLkO1PFE2KM7:TR?= MVfTRW5ITVJ?
KNS-81-FD MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwM{[2Olch|ryP M{fCZ3NCVkeHUh?=
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NCI-H1792 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwM{e2OVUh|ryP MlLmV2FPT0WU
HuH-7 M1OyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwM{e5NUDPxE1? MXTTRW5ITVJ?
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HT-1197 NH6zVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwM{m0OkDPxE1? NX;1RYxZW0GQR1XS
CGTH-W-1 NFHZRnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPtTWM2OD1yLkO5PVE{KM7:TR?= MUHTRW5ITVJ?
KNS-42 M4XHOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUizVmtuUUN3ME2wMlQxODR3IN88US=> M1K4enNCVkeHUh?=
HuO-3N1 NVixOoR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HDU2lEPTB;MD60NFA2PSEQvF2= Ml\qV2FPT0WU
VMRC-RCZ M3f2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33NN2lEPTB;MD60NFMxOyEQvF2= NGnSfplUSU6JRWK=
SW954 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwNECzN|Uh|ryP NHHUNHFUSU6JRWK=
MES-SA NF3lb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPMcnRXUUN3ME2wMlQxPTB3IN88US=> M2TkRXNCVkeHUh?=
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NCI-H1437 NFXhZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TzPWlEPTB;MD60NFgxPSEQvF2= MYPTRW5ITVJ?
U-118-MG NVXBU|c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwNEC5NFQh|ryP NWniXpdqW0GQR1XS
NCI-H1734 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\HfmlEPTB;MD60NlAyOyEQvF2= MXrTRW5ITVJ?
HDLM-2 M{fnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXSOllnUUN3ME2wMlQzODN|IN88US=> MV7TRW5ITVJ?
AU565 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme0TWM2OD1yLkSyOFY5KM7:TR?= MlrkV2FPT0WU
FADU NEDkd3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNEK2OFkh|ryP MVTTRW5ITVJ?
OS-RC-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme1TWM2OD1yLkSzNFg{KM7:TR?= NX;PUlRLW0GQR1XS
CAMA-1 NIXvOndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\ITWM2OD1yLkSzOlI3KM7:TR?= MXzTRW5ITVJ?
MONO-MAC-6 NVS5eIRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNEO4OFkh|ryP MoHxV2FPT0WU
LB831-BLC M4m4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTITWM2OD1yLkS0N|cyKM7:TR?= MVfTRW5ITVJ?
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SCC-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DRXmlEPTB;MD60OFU4QSEQvF2= MXnTRW5ITVJ?
C32 NV:2dGExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvVZ|JKSzVyPUCuOFUzOjlizszN MXjTRW5ITVJ?
BFTC-909 M1vieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\BVWlEPTB;MD60OVI6QSEQvF2= MlvJV2FPT0WU
MEG-01 M2\FWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNEWzO|Mh|ryP NH;LU2xUSU6JRWK=
M14 NXq2PFBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXIcopGUUN3ME2wMlQ2QTd7IN88US=> NEj4[YVUSU6JRWK=
MPP-89 NI\N[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PGUWlEPTB;MD60OlI2PiEQvF2= NVfhbIZWW0GQR1XS
HCC1937 NYHPW2RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\QNWlEPTB;MD60OlM5PCEQvF2= NXPq[Ik5W0GQR1XS
SW837 NVKyVJN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHpfVl5UUN3ME2wMlQ3PzJ{IN88US=> Mof1V2FPT0WU
DU-145 M36xNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzXcWJKSzVyPUCuOFY4OjlizszN NHLsVVJUSU6JRWK=
LB996-RCC NXTuU2lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLPRlN[UUN3ME2wMlQ4ODV2IN88US=> NHfIb|RUSU6JRWK=
C8166 NYrYfpNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLEVnJKSzVyPUCuOFc1KM7:TR?= M4SxfXNCVkeHUh?=
MOLT-4 NVzBXIdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwNEe3N|Qh|ryP NHPHOm5USU6JRWK=
DMS-53 NXLmSIJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWroNII1UUN3ME2wMlQ4QDB7IN88US=> NITRXG9USU6JRWK=
TE-5 NUfyXGE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\BVmlEPTB;MD60PFMxPSEQvF2= M{i1XXNCVkeHUh?=
KYSE-520 M1ezbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjSd5hKSzVyPUCuOFg{PDNizszN MoTzV2FPT0WU
Detroit562 NGjDOFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfudGwyUUN3ME2wMlQ5QDZizszN NFHIco1USU6JRWK=
SIMA MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fM[WlEPTB;MD60PVQyPyEQvF2= MVfTRW5ITVJ?
NCI-H1651 M131bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTSdFhrUUN3ME2wMlQ6PjdizszN NUHMNY9IW0GQR1XS
HCC1599 NECyS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDEbWQ4UUN3ME2wMlQ6QTV3IN88US=> Mnm3V2FPT0WU
ABC-1 M4[0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwNUC0PVYh|ryP NVnySYtuW0GQR1XS
CAL-33 NHvLRZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnNcGVKSzVyPUCuOVA5PDRizszN NGfUdFdUSU6JRWK=
OPM-2 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\vTWM2OD1yLkWwPVM4KM7:TR?= Ml\5V2FPT0WU
RPMI-7951 M{DnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17jS2lEPTB;MD61NFk2PyEQvF2= NWPUcGs3W0GQR1XS
HT-1080 M3vHSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m4NmlEPTB;MD61NVEyQSEQvF2= M37Td3NCVkeHUh?=
LC4-1 NXrOU3BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HZbGlEPTB;MD61NVQxOyEQvF2= NUGyR3hHW0GQR1XS
OVCAR-3 Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vTTWlEPTB;MD61NVU4KM7:TR?= M2DvWHNCVkeHUh?=
CAPAN-1 NXK5VodwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwNUKyPFgh|ryP NHXESnVUSU6JRWK=
SK-OV-3 NH7hTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33RT2lEPTB;MD61NlQ{PCEQvF2= M4XLXnNCVkeHUh?=
HuP-T3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XleWlEPTB;MD61NlgzPyEQvF2= NYLqXHllW0GQR1XS
NCI-H838 M3\uU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vacWlEPTB;MD61Nlg1QSEQvF2= NHjPPIFUSU6JRWK=
K5 MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLDTWM2OD1yLkWzNlAyKM7:TR?= M4DJb3NCVkeHUh?=
CAL-72 M3nibGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwNUOzPFch|ryP MnfnV2FPT0WU
NH-12 NICxfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP0NVhKSzVyPUCuOVM6PTlizszN NXfCcm5lW0GQR1XS
SNB75 NEGzb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNUW3N{DPxE1? NUP0fnQxW0GQR1XS
BPH-1 NVjufpRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7JUJJKSzVyPUCuOVY{PDRizszN Mmm0V2FPT0WU
NOMO-1 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNU[zO|Ih|ryP MlLqV2FPT0WU
G-402 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnyTWM2OD1yLkW2OFk6KM7:TR?= NEfINYFUSU6JRWK=
NCI-H2052 M1u0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jmXWlEPTB;MD61Olc1OSEQvF2= NVvvPI9nW0GQR1XS
RCM-1 M4TaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLETWM2OD1yLkW3NVY3KM7:TR?= MVPTRW5ITVJ?
COR-L279 NVzLNndKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSzTWM2OD1yLkW3NVg2KM7:TR?= MYXTRW5ITVJ?
A253 MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHiOndKSzVyPUCuOVc2OjVizszN NX;WOXFHW0GQR1XS
SK-MM-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqyOY1KSzVyPUCuOVc3PzlizszN M33LcXNCVkeHUh?=
NCI-H1703 NILZR3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3KxeWlEPTB;MD61PVQzPyEQvF2= M3HaUXNCVkeHUh?=
UACC-257 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFftWXlKSzVyPUCuOVk1QDdizszN MVrTRW5ITVJ?
KALS-1 NUP5bpNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH3[2VsUUN3ME2wMlYxODFzIN88US=> NH:wWopUSU6JRWK=
ES5 M{XjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[2RnhKSzVyPUCuOlA1QCEQvF2= MmnxV2FPT0WU
MHH-CALL-2 NYOzUo9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTkTWM2OD1yLk[wPFg5KM7:TR?= NUjOcZZLW0GQR1XS
ChaGo-K-1 NF;JbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHCTWM2OD1yLk[xNlI6KM7:TR?= M1XWZnNCVkeHUh?=
TGBC1TKB MlO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrSPWFKSzVyPUCuOlE6QCEQvF2= NXPZSWJzW0GQR1XS
KU-19-19 M3Prfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwNkS1PFYh|ryP MnrJV2FPT0WU
COLO-684 MkLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHHcWM1UUN3ME2wMlY2PjFzIN88US=> MYfTRW5ITVJ?
LS-1034 NWWwcIdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPLe5VKSzVyPUCuOlU5OTlizszN NILRbFVUSU6JRWK=
RT-112 NFzDUndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrEc2NxUUN3ME2wMlY3PTh5IN88US=> NWjHVYJYW0GQR1XS
Capan-2 NUXIelhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYr4d4ZlUUN3ME2wMlY3PjJ{IN88US=> MnrlV2FPT0WU
HSC-4 M2faNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXTd49KSzVyPUCuOlY3QThizszN MkPFV2FPT0WU
COLO-824 Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTyTWM2OD1yLk[3PFI{KM7:TR?= M3\TOXNCVkeHUh?=
NCI-H2170 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vvW2lEPTB;MD62PFI2QCEQvF2= MYDTRW5ITVJ?
GDM-1 M1:wOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDkfIlKSzVyPUCuOlg1QTRizszN NUHPfVhNW0GQR1XS
KP-4 M1fTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfMXGVKSzVyPUCuOlk2PzNizszN MXTTRW5ITVJ?
VA-ES-BJ MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwNkm5PFYh|ryP NH7EZ2NUSU6JRWK=
KM-H2 NUXsZ5Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\rdmlEPTB;MD63NFA6OSEQvF2= MWjTRW5ITVJ?
HH Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7qW5NZUUN3ME2wMlcxPjZ{IN88US=> NV\GcFNIW0GQR1XS
DK-MG NYLjeWVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwN{GwNVYh|ryP MoXwV2FPT0WU
VM-CUB-1 NWXnSGxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwN{GyOVkh|ryP NFjmOYRUSU6JRWK=
COLO-829 M1H2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzZTWM2OD1yLkexPVg2KM7:TR?= NWT3RmJiW0GQR1XS
OMC-1 M{\i[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwN{KxNFQh|ryP MUfTRW5ITVJ?
NB12 NHvK[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwN{K1NFQh|ryP NW\TOmxiW0GQR1XS
NCI-H28 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrQTWM2OD1yLke0NFg{KM7:TR?= Mn\MV2FPT0WU
A673 M{X3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwN{WxO|ch|ryP NIr3PHlUSU6JRWK=
LB2241-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwN{[wPFch|ryP NXG5ZZBPW0GQR1XS
CCRF-CEM MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTBwN{ewOVIh|ryP M{nhTXNCVkeHUh?=
NCI-H510A M3zqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwN{exPFYh|ryP M1\0Z3NCVkeHUh?=
SW48 NF;EWJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnl[JRlUUN3ME2wMlc4OzN|IN88US=> NIjJ[mhUSU6JRWK=
NCI-H2081 NVGwS4JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jLUmlEPTB;MD63PFE1PyEQvF2= MXfTRW5ITVJ?
RMG-I MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwN{iyNVIh|ryP MmTyV2FPT0WU
LU-99A MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDRdohKSzVyPUCuO|g1OTNizszN M1j5[HNCVkeHUh?=
KP-N-YS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwN{i5NlEh|ryP M4XN[3NCVkeHUh?=
MDA-MB-231 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTyToxKSzVyPUCuPFAyOzFizszN MWHTRW5ITVJ?
U031 NYfBfJA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:xW2E2UUN3ME2wMlgyPDJ|IN88US=> MXXTRW5ITVJ?
EVSA-T M1n2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkO2TWM2OD1yLkixOlczKM7:TR?= M37nTnNCVkeHUh?=
MDA-MB-157 NEmwXXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vZSGlEPTB;MD64NlI4OSEQvF2= NGDCeVJUSU6JRWK=
EHEB MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnGTWM2OD1yLkiyNlc3KM7:TR?= NF;SS2dUSU6JRWK=
KINGS-1 NYPKZ4toT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zPbmlEPTB;MD64NlU2PSEQvF2= MknzV2FPT0WU
23132-87 NGjR[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TuWWlEPTB;MD64Nlg1OyEQvF2= MWPTRW5ITVJ?
EFO-21 NHLnW4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwOESwPFkh|ryP NFjpOWVUSU6JRWK=
DOK NYTYUYRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm4S|FFUUN3ME2wMlg1QCEQvF2= Mm[2V2FPT0WU
NCI-H2171 MmLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TEdGlEPTB;MD64OFk3KM7:TR?= NEXneGdUSU6JRWK=
NCI-SNU-5 NFXsRolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rYeWlEPTB;MD64OVU4KM7:TR?= MmLUV2FPT0WU
SK-N-DZ MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLJfoxxUUN3ME2wMlg2QTR|IN88US=> NWjuPY4zW0GQR1XS
SNU-C2B MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTjTWM2OD1yLki2PFAyKM7:TR?= NIHiUIZUSU6JRWK=
CP66-MEL NX[3SWl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwOEexNUDPxE1? MoP6V2FPT0WU
SN12C Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwOEi2N|ch|ryP Mk\kV2FPT0WU
A172 MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWK3[mxJUUN3ME2wMlg5Pjl6IN88US=> Mlz3V2FPT0WU
NCI-H2347 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX72TW82UUN3ME2wMlg5PzV|IN88US=> NVr4UYR2W0GQR1XS
NCI-H2228 NVrqUYdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnpeGJKSzVyPUCuPFk{OzlizszN M2rkXnNCVkeHUh?=
SNU-387 NHvScFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfMbmZ2UUN3ME2wMlkxOjZ2IN88US=> MUTTRW5ITVJ?
SK-MEL-24 MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS4TWM2OD1yLkmxN|Q1KM7:TR?= MmP2V2FPT0WU
MDA-MB-468 M2LVdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HPRWlEPTB;MD65NVc{KM7:TR?= NInLV5pUSU6JRWK=
NCI-H1694 NFjyRnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3ITWM2OD1yLkmxPFc3KM7:TR?= NFXSWJhUSU6JRWK=
CCF-STTG1 NXLUXZdjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwOUK2N|ch|ryP M{fRRnNCVkeHUh?=
K052 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjkOGtKSzVyPUCuPVQxPDdizszN MXHTRW5ITVJ?
NCI-H446 MnvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLrbVczUUN3ME2wMlk2ODFizszN M{\0WHNCVkeHUh?=
MFE-280 NV3wdFBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHT[FFKSzVyPUCuPVYzQTFizszN NUSzWHE4W0GQR1XS
KU812 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvaNpRMUUN3ME2wMlk6Ozh7IN88US=> NXG3S4RMW0GQR1XS
MDA-MB-361 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvTV2plUUN3ME2wMlk6Pzd5IN88US=> M1nWTXNCVkeHUh?=
Raji MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImyeYJKSzVyPUGuNFIzPjdizszN M2r6NHNCVkeHUh?=
TE-6 NIrZbWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwMEO1OlYh|ryP MXPTRW5ITVJ?
CAL-148 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT0fnY6UUN3ME2xMlA1PDR|IN88US=> Ml;OV2FPT0WU
NCI-H1963 M3;Y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHsOI1KSzVyPUGuNFQ2PTNizszN Ml3mV2FPT0WU
SK-N-AS NH25W3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFwMES2PFUh|ryP MU\TRW5ITVJ?
RERF-LC-MS NHP4c|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXiTWM2OD1zLkC2N|Q6KM7:TR?= MXnTRW5ITVJ?
BEN NEfGdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrDVGVKSzVyPUGuNFcyOzdizszN NYTxZVUyW0GQR1XS
CAS-1 NUe5WIdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXneml{UUN3ME2xMlA6OTJ|IN88US=> M2KyZnNCVkeHUh?=
SW780 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETLXpdKSzVyPUGuNFkyQDFizszN MmTrV2FPT0WU
LU-65 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwMEm0NUDPxE1? M3L0cXNCVkeHUh?=
D-283MED NIW1enZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\6[HpKSzVyPUGuNVIzPzJizszN Mn7QV2FPT0WU
HCC2157 NILz[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nPUGlEPTB;MT6xN|Y1OiEQvF2= MV;TRW5ITVJ?
RCC10RGB MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTDTWM2OD1zLkG0NFA3KM7:TR?= NID4ZYxUSU6JRWK=
PLC-PRF-5 NVfDUpZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fkdGlEPTB;MT6xOVIzQSEQvF2= NVjObZBnW0GQR1XS
H4 NFfMbGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZUppKSzVyPUGuNVU1OzlizszN MX3TRW5ITVJ?
TUR NVe2XVdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwMUW3OVIh|ryP NELjSlFUSU6JRWK=
NCI-H2141 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwMUi5OFYh|ryP M3;RO3NCVkeHUh?=
PFSK-1 NF3XcGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[xcJU{UUN3ME2xMlIxPTN{IN88US=> NHG1Z|VUSU6JRWK=
SK-MEL-28 M4fac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrLTWM2OD1zLkKzNlIyKM7:TR?= NXnveZRFW0GQR1XS
SCC-9 NUOwdG5rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTFwMkO2OlUh|ryP MXPTRW5ITVJ?
T47D NWnOeWhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL5dIkxUUN3ME2xMlI{Pjl4IN88US=> MUTTRW5ITVJ?
TCCSUP M3rKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfhU4RKSzVyPUGuNlUxOjlizszN M4LTZ3NCVkeHUh?=
SU-DHL-1 NE\OOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXmTWM2OD1zLkK1NVE5KM7:TR?= NHu0OIVUSU6JRWK=
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LU-165 M{DqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;ETWM2OD13Lkm5NFAzKM7:TR?= MWTTRW5ITVJ?
YAPC NWLpcpl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7NdFlKSzVyPUWuPVkxPjhizszN M13iVnNCVkeHUh?=
LU-139 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLTd|dkUUN3ME22MlA5OzZ6IN88US=> MX3TRW5ITVJ?
D-502MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTZwM{KwOFch|ryP NXLydXNLW0GQR1XS
IST-SL1 M2Dhe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\4bZZKSzVyPU[uOVM6PDhizszN NVrxNmYzW0GQR1XS
DG-75 NUXwe3dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLhSohbUUN3ME22Mlg5Pzh4IN88US=> M1n2UnNCVkeHUh?=
NCI-H1155 Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HSRWlEPTB;Nj65OVU5OSEQvF2= NGfD[WtUSU6JRWK=
EFE-184 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zjUWlEPTB;Nz6zNVY6PSEQvF2= NYTy[VNlW0GQR1XS
AsPC-1 NXvEcm0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XDW2lEPTB;Nz60PFgxPyEQvF2= MYTTRW5ITVJ?
SW948 NYr3WJNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\GUmlKSzVyPUeuOVg{QTVizszN MmPKV2FPT0WU
NCI-H524 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:0VmdVUUN3ME25MlU5PjJ6IN88US=> NGPI[IhUSU6JRWK=
KOSC-2 M2PIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\YSpR[UUN3ME25MlYzQDN2IN88US=> NVPKUIVrW0GQR1XS
T-24 NXvIPW5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPNTWM2OD17Lkm0OFE2KM7:TR?= Ml;qV2FPT0WU
NCI-H748 MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXUb5JKSzVyPUGwMlY{QTdizszN MX;TRW5ITVJ?
NCI-H23 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PkR2lEPTB;MUCuOlQ1OiEQvF2= NHfTe4FUSU6JRWK=
UACC-812 M2PBUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrmOVJKSzVyPUGxMlcyPyEQvF2= NGX4OHNUSU6JRWK=
SCLC-21H NGfyfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLCTZBKSzVyPUGyMlE2PTFizszN Mk[wV2FPT0WU
NCI-SNU-16 NGHydmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF|LkGyOVgh|ryP M1f2OnNCVkeHUh?=
HD-MY-Z NU\Oc3ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;tNXdKSzVyPUG0MlY{PjNizszN NVv5WnZMW0GQR1XS
SK-N-FI M2fP[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HDVWlEPTB;MUSuPFkyOiEQvF2= NIe2WFBUSU6JRWK=
LB647-SCLC Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;YTGlEPTB;MUWuO|E6PSEQvF2= M4XP[XNCVkeHUh?=
NCI-H345 NWTNU5B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLaTWM2OD1zNz6zOFMh|ryP MnHyV2FPT0WU
NCI-H1563 NV7RNZJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\RNGhTUUN3ME2xPE44PjBzIN88US=> NVzTVFFwW0GQR1XS
RL NHrlSYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPrNYtOUUN3ME2yNU4zPjV4IN88US=> Ml3GV2FPT0WU
KY821 M{fuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJ{LkC1OVMh|ryP NWT1fZdIW0GQR1XS
JVM-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fIbGlEPTB;MkWuNFQyOyEQvF2= NXXnVJBbW0GQR1XS
NCI-H1793 NICz[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzycnpKSzVyPUK4MlU1QTlizszN NF35dG9USU6JRWK=
LU-134-A MoWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXqTWM2OD1|MD6yNFM4KM7:TR?= MnXFV2FPT0WU
NCI-H1395 Ml;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGwTWM2OD1|Mj6yOFMyKM7:TR?= NEL1PFdUSU6JRWK=
NCI-H1993 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDmd3llUUN3ME2zNk45OjF6IN88US=> MULTRW5ITVJ?
P31-FUJ NV3XNYluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoWyTWM2OD1|Mz60PFk6KM7:TR?= NWPOPJIyW0GQR1XS
LS-513 NFyy[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN3Lki4O|kh|ryP M3i3fnNCVkeHUh?=
SK-MEL-1 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1O2TWlEPTB;NECuN|Q6QSEQvF2= M2Tqe3NCVkeHUh?=
SW684 NIHDdIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTR|Lkm2OlEh|ryP NH3LcmxUSU6JRWK=
COR-L88 NV\Ud|U{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTR2LkC2OlUh|ryP M4C4W3NCVkeHUh?=
NCI-H889 NHm5WHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH2TWM2OD12NT6wNFg4KM7:TR?= NGPBelhUSU6JRWK=
TALL-1 Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILnV5VKSzVyPUS2MlEyQTlizszN MmrmV2FPT0WU
KARPAS-299 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTR5LkG5PVMh|ryP M2XwXHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin D1 / p27 Kip1 ; 

PubMed: 28382170     


Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1.

p-Cyclin D1 ; 

PubMed: 28035994     


Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control;

p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; 

PubMed: 28035994     


Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;

28382170 28035994
Growth inhibition assay
Cell proliferation ; 

PubMed: 28035994     


Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control.

Cell viability; 

PubMed: 21368880     


H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D. 

28035994 21368880
In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
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Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
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  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A
Smiles COC\1=CC(=NC1=C\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID