Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Cited by 55 Publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 M3zRNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LX[WlEPTB;MD6wNFAxOzF5IN88US=> NYj3XmNpW0GQR1XS
SK-MEL-30 NFPBZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfFc4EzUUN3ME2wMlAxODN3NTFOwG0> M4r4cXNCVkeHUh?=
NALM-6 NY\FfpJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMECwN|U3KM7:TR?= NFnCU|lUSU6JRWK=
KYSE-450 M2nLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTvTWM2OD1yLkCwNFQ3QSEQvF2= MW\TRW5ITVJ?
BHY MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm1ZoVKSzVyPUCuNFAxPjBzIN88US=> M{XycnNCVkeHUh?=
GR-ST M3:0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETjeI5KSzVyPUCuNFAxPjR6IN88US=> MVvTRW5ITVJ?
786-0 NEH0TndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2xTWM2OD1yLkCwNFc4PiEQvF2= NHjFUJhUSU6JRWK=
C-33-A M1;jNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPmb2lKSzVyPUCuNFAxQDR6IN88US=> NHv6bIhUSU6JRWK=
BHT-101 M{\m[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLOcVVKSzVyPUCuNFAyODZizszN MVnTRW5ITVJ?
EB2 NEjjUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf2SoRKSzVyPUCuNFAyOThizszN NGCzW5RUSU6JRWK=
G-361 M1vhdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjlRnNKSzVyPUCuNFAyOjRizszN Ml;uV2FPT0WU
KE-37 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEflT3hKSzVyPUCuNFAyOjhizszN NVHOTJllW0GQR1XS
MHH-PREB-1 MmPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT2TWM2OD1yLkCwNVQh|ryP M3myNnNCVkeHUh?=
MCF7 NHnwV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fIb2lEPTB;MD6wNFE2QSEQvF2= NFLFWWFUSU6JRWK=
LOUCY MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMECxO|Uh|ryP M4Ptc3NCVkeHUh?=
EW-7 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;uNZdKSzVyPUCuNFAyPzVizszN MoTDV2FPT0WU
KYSE-510 NVzPWYhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMECyN|Mh|ryP M4jhXnNCVkeHUh?=
SK-MEL-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXaVHBEUUN3ME2wMlAxOjZ2IN88US=> NFqzd3NUSU6JRWK=
HAL-01 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXLTWM2OD1yLkCwNlk4KM7:TR?= NGTZRXRUSU6JRWK=
HCC2998 M1zjb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3tTWM2OD1yLkCwN|M2KM7:TR?= M2DOXHNCVkeHUh?=
A375 MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMECzOUDPxE1? MkHUV2FPT0WU
MZ7-mel NV;xc3Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;vV4dKSzVyPUCuNFA{QTlizszN Mn25V2FPT0WU
SH-4 M2\Bb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M162R2lEPTB;MD6wNFQyPyEQvF2= MWDTRW5ITVJ?
HT-144 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3sWnpKSzVyPUCuNFA1OyEQvF2= MmPGV2FPT0WU
KYSE-140 NF\MV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEC0N|Uh|ryP MX\TRW5ITVJ?
PSN1 Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrOOmo5UUN3ME2wMlAxPDZ5IN88US=> M1ewUnNCVkeHUh?=
COLO-679 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEC0PVgh|ryP M1LzTXNCVkeHUh?=
SW620 NIn0dmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEC1NVEh|ryP NInNOmRUSU6JRWK=
HGC-27 M{PSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm5UW9DUUN3ME2wMlAxPTJ2IN88US=> M1fWd3NCVkeHUh?=
IGROV-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\XeGdLUUN3ME2wMlAxPiEQvF2= MVrTRW5ITVJ?
IGR-1 NIHad5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy1OnNKSzVyPUCuNFA3ODFizszN MWXTRW5ITVJ?
EW-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\ETmd2UUN3ME2wMlAxPjVzIN88US=> NYW5UFFLW0GQR1XS
769-P MkX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn2TWM2OD1yLkCwOlc5KM7:TR?= M3\USXNCVkeHUh?=
HN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEC2O|kh|ryP Ml\hV2FPT0WU
SIG-M5 NY\Sco1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnRRoZKSzVyPUCuNFA4OSEQvF2= MkftV2FPT0WU
IST-MEL1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofKTWM2OD1yLkCwPFE5KM7:TR?= M2LWWXNCVkeHUh?=
ST486 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjpeGtsUUN3ME2wMlAxQDJ3IN88US=> M{fZOHNCVkeHUh?=
ES7 NIn2NIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Tt[GlEPTB;MD6wNFg1PiEQvF2= MkPFV2FPT0WU
GAK NX;pT|FKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jTfmlEPTB;MD6wNFg1QCEQvF2= MnfEV2FPT0WU
BB30-HNC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEC4OVgh|ryP NVqxU4hJW0GQR1XS
IPC-298 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nDUWlEPTB;MD6wNFkzPyEQvF2= MWLTRW5ITVJ?
NKM-1 NIS2TFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULTZ4dkUUN3ME2wMlAxQTd{IN88US=> NX;rTZh2W0GQR1XS
RKO NUXFZ2w3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHxZpdyUUN3ME2wMlAyODR2IN88US=> M{n0WXNCVkeHUh?=
ACN NH7HT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEGxN|Eh|ryP M1jpWXNCVkeHUh?=
SW1417 M{DIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K1WmlEPTB;MD6wNVIzPSEQvF2= NIHuS|NUSU6JRWK=
SR NWLqWWdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrnTWM2OD1yLkCxNlM2KM7:TR?= M1jjcnNCVkeHUh?=
SNG-M NWf2dYRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PEU2lEPTB;MD6wNVMyPyEQvF2= MoHJV2FPT0WU
CAL-12T Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHETWM2OD1yLkCxN|Q3KM7:TR?= Mn7RV2FPT0WU
HSC-3 NFvicoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DzNGlEPTB;MD6wNVM2PSEQvF2= MnezV2FPT0WU
DOHH-2 NEjySZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ex[mlEPTB;MD6wNVQyOiEQvF2= M2T6VXNCVkeHUh?=
NB69 M{fZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m1TWlEPTB;MD6wNVU3PSEQvF2= MXjTRW5ITVJ?
LC-2-ad NFjKUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT4SpV{UUN3ME2wMlAyPThzIN88US=> MXzTRW5ITVJ?
RVH-421 M1rWPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC1cmtEUUN3ME2wMlAyPjd2IN88US=> M{HyenNCVkeHUh?=
TGW NFPico5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{CwZWlEPTB;MD6wNVc{QSEQvF2= M37uOHNCVkeHUh?=
HCC1569 Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTOTWM2OD1yLkCxO|k4KM7:TR?= MlLHV2FPT0WU
CAL-85-1 M37tXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEG4N|Ih|ryP M4jsfHNCVkeHUh?=
RPMI-8402 NXjR[XlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjNb|JKSzVyPUCuNFE5PThizszN NUL5XIV{W0GQR1XS
THP-1 M3TPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KxeGlEPTB;MD6wNVk6QCEQvF2= MUfTRW5ITVJ?
ONS-76 NEHCd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4CzRWlEPTB;MD6wNlA{PiEQvF2= Mk\yV2FPT0WU
A2780 NYHOblhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C2b2lEPTB;MD6wNlA4QSEQvF2= MUPTRW5ITVJ?
RPMI-2650 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkiyTWM2OD1yLkCyNlk3KM7:TR?= MnjYV2FPT0WU
MEL-HO M{Psfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXHcXdKSzVyPUCuNFI{PDhizszN Ml[5V2FPT0WU
MC-CAR M3fifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX65RnlMUUN3ME2wMlAzOzV4IN88US=> MVfTRW5ITVJ?
HSC-2 NVmzWZU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C0NWlEPTB;MD6wNlQ3PiEQvF2= NYDLe2ZjW0GQR1XS
MEL-JUSO NHX0b3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrrZnpKSzVyPUCuNFI1PzNizszN NIj0fXdUSU6JRWK=
CAL-62 M33mUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHid4FVUUN3ME2wMlAzPjB{IN88US=> MlnmV2FPT0WU
DMS-273 M373Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\nfJZKSzVyPUCuNFI5PDdizszN NEPE[HRUSU6JRWK=
S-117 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDLTWM2OD1yLkCyPVA3KM7:TR?= NEXXOWlUSU6JRWK=
SUP-T1 NH63d2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPtO|NkUUN3ME2wMlAzQTR7IN88US=> NX\WPWpqW0GQR1XS
MZ2-MEL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXuTWM2OD1yLkCyPVU6KM7:TR?= M13NVHNCVkeHUh?=
KYSE-270 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEK5O|Yh|ryP M4PMXnNCVkeHUh?=
CMK NHj5XZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEOwNlMh|ryP NInXXmlUSU6JRWK=
8505C NIHl[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHZW3RKSzVyPUCuNFMxPCEQvF2= MWXTRW5ITVJ?
NUGC-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXnW5VlUUN3ME2wMlA{ODR6IN88US=> MXjTRW5ITVJ?
A101D NIjKRlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G5WGlEPTB;MD6wN|A2PSEQvF2= MYLTRW5ITVJ?
G-401 NHrpOG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HkTmlEPTB;MD6wN|A6OyEQvF2= NGfEblNUSU6JRWK=
OVCAR-8 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzTWM2OD1yLkCzNVA4KM7:TR?= NWnpOmM{W0GQR1XS
IMR-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS4R4lPUUN3ME2wMlA{OjR2IN88US=> NIXUTXRUSU6JRWK=
DoTc2-4510 M2XUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLTU3hjUUN3ME2wMlA{Ozl|IN88US=> NVLjblZxW0GQR1XS
HOS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\T[2lEPTB;MD6wN|Q4OyEQvF2= MXjTRW5ITVJ?
HEC-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTjTWM2OD1yLkCzOlgh|ryP NVH3ZlRNW0GQR1XS
SW756 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEO4NlEh|ryP NE[2RVlUSU6JRWK=
NCI-H64 NGHIZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXlUFhKSzVyPUCuNFM5PDJizszN M2HBRnNCVkeHUh?=
EW-16 NXTUTW1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES3N3lKSzVyPUCuNFM6ODlizszN MYHTRW5ITVJ?
CAL-51 Mke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n3ZmlEPTB;MD6wOFAxPSEQvF2= Mn3XV2FPT0WU
KYSE-150 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki5TWM2OD1yLkC0NFEyKM7:TR?= NFq0[XRUSU6JRWK=
SW1710 MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMESwNVgh|ryP MlLWV2FPT0WU
HuP-T4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMESxNVgh|ryP NUXEN2NFW0GQR1XS
LB373-MEL-D MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M324[WlEPTB;MD6wOFI{OiEQvF2= NEC5W2JUSU6JRWK=
EW-13 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1znSWlEPTB;MD6wOFQxPiEQvF2= Mmm4V2FPT0WU
HT-29 NELXPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jUe2lEPTB;MD6wOFQ6KM7:TR?= NXu2NoRWW0GQR1XS
SCC-25 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTvOoNKSzVyPUCuNFQ1QTRizszN MYnTRW5ITVJ?
REH NIH2ellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMES2N|Uh|ryP M{D2UnNCVkeHUh?=
L-363 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TtXGlEPTB;MD6wOFY4QSEQvF2= MmG5V2FPT0WU
NCI-H1770 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrsTWM2OD1yLkC0Olk4KM7:TR?= MXTTRW5ITVJ?
CHL-1 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMES4OVch|ryP M4D2ZnNCVkeHUh?=
ES1 NEPEXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3xboxrUUN3ME2wMlA1QDh3IN88US=> M3TRUXNCVkeHUh?=
SCC-15 NEDRUWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j3UGlEPTB;MD6wOFkxOiEQvF2= Mmn2V2FPT0WU
MRK-nu-1 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nmWWlEPTB;MD6wOFk{PiEQvF2= MXTTRW5ITVJ?
PF-382 NVvqXpB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvIe5lKSzVyPUCuNFQ6OzlizszN MYTTRW5ITVJ?
COLO-680N M{HlOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TzO2lEPTB;MD6wOVA1PyEQvF2= M3XiVHNCVkeHUh?=
LK-2 NWS5SVV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLWbo5KSzVyPUCuNFUxPjNizszN MVnTRW5ITVJ?
NCI-H2342 MljQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLTTWM2OD1yLkC1NVE4KM7:TR?= M2HDSHNCVkeHUh?=
HMV-II MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnCfmROUUN3ME2wMlA2OjN7IN88US=> NIG2c3BUSU6JRWK=
PC-14 NIP0VYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7seVZKSzVyPUCuNFUzPTJizszN MkjwV2FPT0WU
COLO-320-HSR MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrLNZVKSzVyPUCuNFUzQDlizszN NFXSfHdUSU6JRWK=
697 NInBSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEWzNlMh|ryP NYrFdmUyW0GQR1XS
NEC8 NFTHZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PB[mlEPTB;MD6wOVU6KM7:TR?= NFKwPVJUSU6JRWK=
LCLC-97TM1 NEDmUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvaTWM2OD1yLkC1OVk1KM7:TR?= NWL0PXZoW0GQR1XS
Daoy MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3hTWM2OD1yLkC1OlE3KM7:TR?= MXHTRW5ITVJ?
ETK-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjmcJZKSzVyPUCuNFU3PzJizszN NGPmToJUSU6JRWK=
A388 NGPhdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV31O2RIUUN3ME2wMlA2Pjl3IN88US=> MWLTRW5ITVJ?
COLO-205 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHaTWM2OD1yLkC1O|E3KM7:TR?= MW\TRW5ITVJ?
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EB-3 NV;EUZliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfWUGRKSzVyPUCuNVc{OSEQvF2= MmDuV2FPT0WU
HCC1143 NX\pe4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP6TWM2OD1yLkG3N|k3KM7:TR?= NGnrNotUSU6JRWK=
DJM-1 NH;ZXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\uTWM2OD1yLkG3OFUyKM7:TR?= NGqxd5BUSU6JRWK=
BT-474 NVS4VmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLRTWM2OD1yLkG3OFg6KM7:TR?= NHf4eYZUSU6JRWK=
BB65-RCC NX\SZmJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDvSok3UUN3ME2wMlE4PTR3IN88US=> NHf0[49USU6JRWK=
NCI-H292 Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfUTWM2OD1yLkG3OlAyKM7:TR?= Ml;YV2FPT0WU
MKN28 NWXyPW5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfDTWM2OD1yLkG3OlU{KM7:TR?= MXnTRW5ITVJ?
TK10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PEV2lEPTB;MD6xO|cxOiEQvF2= M33FWHNCVkeHUh?=
TYK-nu NF7KN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe5[XFUUUN3ME2wMlE4QTR7IN88US=> M3vNV3NCVkeHUh?=
8305C MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnqTYZKSzVyPUCuNVc6PzFizszN Mn7CV2FPT0WU
MV-4-11 NUDyXYRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLQV|Y1UUN3ME2wMlE4QTd5IN88US=> M17ZdXNCVkeHUh?=
NCI-H522 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7GTWM2OD1yLkG4NFk1KM7:TR?= NHK5[YxUSU6JRWK=
Hs-578-T NFrlZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWxTWM2OD1yLkG4NlkzKM7:TR?= M1;XeXNCVkeHUh?=
LCLC-103H MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDtNo9KSzVyPUCuNVg2OjdizszN NVvGRXlXW0GQR1XS
MHH-ES-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPuTWM2OD1yLkG4OlI6KM7:TR?= MmTGV2FPT0WU
NCI-H441 M2XlN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n0eWlEPTB;MD6xPVE1QCEQvF2= MYLTRW5ITVJ?
AM-38 M3m3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUGye2hnUUN3ME2wMlE6OjJ3IN88US=> MlTvV2FPT0WU
SW1783 M4O0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPDTWM2OD1yLkG5N|A2KM7:TR?= MVvTRW5ITVJ?
SK-HEP-1 MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLYRWdKSzVyPUCuNVk3OzdizszN M{K1dXNCVkeHUh?=
OAW-28 NVfhPWVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fnbWlEPTB;MD6yNFE4QCEQvF2= NH;EWFBUSU6JRWK=
TE-15 NYHjZVN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnkTWM2OD1yLkKwNlUzKM7:TR?= MVnTRW5ITVJ?
HCE-4 NILGVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGz[ndsUUN3ME2wMlIxOjh2IN88US=> MUHTRW5ITVJ?
JiyoyeP-2003 M{DLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDFTWM2OD1yLkKwN|M3KM7:TR?= NVX6TXZkW0GQR1XS
OVCAR-4 MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTQSYtIUUN3ME2wMlIxPjJ6IN88US=> M{fSOnNCVkeHUh?=
SNU-449 NH;3WFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPN[IdKSzVyPUCuNlA4QTdizszN MVPTRW5ITVJ?
SBC-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD4NnJ1UUN3ME2wMlIyOjF3IN88US=> M3XIcXNCVkeHUh?=
T84 NX3vSmtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXZN2d4UUN3ME2wMlIyOjR6IN88US=> NWPPO3YxW0GQR1XS
LP-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDlSFE3UUN3ME2wMlIyOzB{IN88US=> M1;EV3NCVkeHUh?=
MG-63 M2[wcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMkGzPFIh|ryP NX7GbWllW0GQR1XS
OAW-42 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX2THlKSzVyPUCuNlE1PzhizszN MorMV2FPT0WU
L-540 NWLScZFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfaZlNKSzVyPUCuNlE2QThizszN NXf0dGdDW0GQR1XS
RH-1 M3;aT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPQR3JKSzVyPUCuNlIzPDJizszN NFXvdYZUSU6JRWK=
HCT-15 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPIRmlKSzVyPUCuNlI1QDRizszN NFv0OlhUSU6JRWK=
OCUB-M MnqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HMcmlEPTB;MD6yNlQ5QCEQvF2= NIrT[FJUSU6JRWK=
GP5d NHPse5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMkK1Nlgh|ryP NU\Eb4lKW0GQR1XS
NCI-H2030 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj6TolKSzVyPUCuNlI4OzRizszN M1LxZnNCVkeHUh?=
ML-2 M4jqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4T5SWlEPTB;MD6yNlg5QSEQvF2= MYjTRW5ITVJ?
CAL-39 NEj4cGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXWTWM2OD1yLkKyPVM3KM7:TR?= NVPvc5QyW0GQR1XS
MIA-PaCa-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMkOyPFch|ryP NIf5XXhUSU6JRWK=
TE-9 NGnkcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLxTWM2OD1yLkKzN|Ih|ryP MWjTRW5ITVJ?
LB2518-MEL MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLwfY1KSzVyPUCuNlM{PzJizszN NGm1bVBUSU6JRWK=
DB M4LISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j0UGlEPTB;MD6yN|Q{QCEQvF2= NF\PXFZUSU6JRWK=
NCI-H596 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnsZVBKSzVyPUCuNlM2PzFizszN MoPwV2FPT0WU
SW1990 NFvSNlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuyWId[UUN3ME2wMlI{QTR4IN88US=> NH7yPHBUSU6JRWK=
P30-OHK M2fVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrzXFJxUUN3ME2wMlI1ODVizszN NHHOZWdUSU6JRWK=
ALL-PO NEO5O4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrXPYpKSzVyPUCuNlQyPjlizszN MVzTRW5ITVJ?
Saos-2 M3zzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PQfWlEPTB;MD6yOFU4OSEQvF2= M2O1e3NCVkeHUh?=
MFH-ino NGXqRmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMkS2PVIh|ryP NX20Sot2W0GQR1XS
OE33 NV7EemV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMkWxNUDPxE1? MWnTRW5ITVJ?
Calu-3 NFzCN5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPVfZdxUUN3ME2wMlI2Ojl5IN88US=> M4fVTXNCVkeHUh?=
HT MnHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrSWmU2UUN3ME2wMlI2PjJzIN88US=> NUS5b|J1W0GQR1XS
LXF-289 M{ThZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMkW5PFQh|ryP M4\rNHNCVkeHUh?=
KGN MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;IbIRKSzVyPUCuNlYxQDlizszN M33TTHNCVkeHUh?=
NCI-H1417 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjxSGhKSzVyPUCuNlY2OjRizszN MYPTRW5ITVJ?
SF126 NE[3OWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMkezNFIh|ryP MY\TRW5ITVJ?
SAS NXXC[VR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2CwUGlEPTB;MD6yO|MxQCEQvF2= NWGyOo4xW0GQR1XS
22RV1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r2W2lEPTB;MD6yO|M4QCEQvF2= NXnI[GZFW0GQR1XS
GI-1 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TBXWlEPTB;MD6yO|Q5PyEQvF2= NXnYb2JMW0GQR1XS
ES3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13DOWlEPTB;MD6yO|c3OyEQvF2= M3XKVXNCVkeHUh?=
NB1 MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMke4O|Yh|ryP NELyUpVUSU6JRWK=
NCI-H650 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMkizNFIh|ryP NEmxRW5USU6JRWK=
IST-MES1 NFXWXYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDme2lKSzVyPUCuNlg2PTRizszN Mkf4V2FPT0WU
UM-UC-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nxfWlEPTB;MD6yPVE1KM7:TR?= MoLxV2FPT0WU
CAL-120 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTDTWM2OD1yLkK5OlMyKM7:TR?= MnzCV2FPT0WU
UACC-62 M1viSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C3UGlEPTB;MD6zNFI1OSEQvF2= NV\0WWlNW0GQR1XS
TE-11 M4TMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwM{CyOFkh|ryP NHHmO41USU6JRWK=
MKN1 MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H5NmlEPTB;MD6zNFM3KM7:TR?= NFr3UlVUSU6JRWK=
KS-1 MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TMNGlEPTB;MD6zNFUzPiEQvF2= NVLoT4R4W0GQR1XS
GCIY M{n4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK3TWM2OD1yLkOxNFAzKM7:TR?= NIrPb2VUSU6JRWK=
OVCAR-5 NXLsUZlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PtcmlEPTB;MD6zNVExPiEQvF2= NHi0PYVUSU6JRWK=
U-266 M3\zfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDKc4djUUN3ME2wMlMyOTR5IN88US=> M2DaRnNCVkeHUh?=
Calu-1 NF\qVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjLVJluUUN3ME2wMlMyOjh7IN88US=> NHr1R3hUSU6JRWK=
SK-LMS-1 NVvwVGdzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PEPWlEPTB;MD6zNVQzQSEQvF2= MYLTRW5ITVJ?
COLO-741 NF6wbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwM{G2NVQh|ryP MYfTRW5ITVJ?
RPMI-8226 M1q5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGwcJJWUUN3ME2wMlMyPjRzIN88US=> M3r4T3NCVkeHUh?=
KM12 M{n3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfrSpdEUUN3ME2wMlMyQDNizszN NWrJVmx5W0GQR1XS
NMC-G1 NIjUT3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfDXJhKSzVyPUCuN|E5PiEQvF2= NYXrNGxsW0GQR1XS
SJRH30 NWnhOJJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwM{KwOVIh|ryP NGHwNnNUSU6JRWK=
COR-L105 NYnGNVEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7rPJBKSzVyPUCuN|IzOThizszN MVXTRW5ITVJ?
IM-9 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HBc2lEPTB;MD6zN|AzOSEQvF2= M2O5WHNCVkeHUh?=
TE-12 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITZXm1KSzVyPUCuN|M{OTdizszN NY\CTZg3W0GQR1XS
KG-1 NIDSSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{O0N|Ih|ryP NV3vXYNyW0GQR1XS
U251 M1flR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXsZ5hKSzVyPUCuN|M1PTZizszN NFr3fFVUSU6JRWK=
EFO-27 NVyxZXN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwM{O5OVEh|ryP MUTTRW5ITVJ?
EW-24 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrNNIp5UUN3ME2wMlM{QTh2IN88US=> MX;TRW5ITVJ?
SF295 MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwM{O5PVkh|ryP NEL4cnRUSU6JRWK=
MC-IXC NXnSU5NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwM{S1JO69VQ>? M17ueHNCVkeHUh?=
NCI-H2405 NUDiVFJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33PPGlEPTB;MD6zOFc{OiEQvF2= NGnRN5BUSU6JRWK=
NCI-H2009 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HNb2lEPTB;MD6zOFc{QSEQvF2= NI\zcItUSU6JRWK=
LB1047-RCC NHvWVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqxdFBKSzVyPUCuN|U5OTVizszN NFTzeHVUSU6JRWK=
KNS-81-FD NIHEdpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwM{[2Olch|ryP NYj1TFlNW0GQR1XS
HOP-92 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC0TWM2OD1yLkO2PFMh|ryP MYnTRW5ITVJ?
L-428 NYDIN3pkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvN[m15UUN3ME2wMlM4ODF4IN88US=> MlWzV2FPT0WU
C3A MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;Wd49KSzVyPUCuN|c{PzlizszN MU\TRW5ITVJ?
NCI-H1792 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwM{e2OVUh|ryP MnTHV2FPT0WU
HuH-7 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\4[ppVUUN3ME2wMlM4QTFizszN MX\TRW5ITVJ?
AGS NI\USoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz6UFFuUUN3ME2wMlM5PjN6IN88US=> MYPTRW5ITVJ?
HT-1197 MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfTTo9EUUN3ME2wMlM6PDZizszN NVn4OVhvW0GQR1XS
CGTH-W-1 NEjMdnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv5TWM2OD1yLkO5PVE{KM7:TR?= NWLHWpZmW0GQR1XS
KNS-42 NUHhPI43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYmxe5EyUUN3ME2wMlQxODR3IN88US=> M1q0XXNCVkeHUh?=
HuO-3N1 NF\SOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfCTWM2OD1yLkSwNFU2KM7:TR?= NH\4OI1USU6JRWK=
VMRC-RCZ NGf5R5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNECzNFMh|ryP NFXNWFZUSU6JRWK=
SW954 NVLER5BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjoTWM2OD1yLkSwN|M2KM7:TR?= NUHYRZNvW0GQR1XS
MES-SA MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTRXJlLUUN3ME2wMlQxPTB3IN88US=> MXjTRW5ITVJ?
Ca-Ski MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O4[mlEPTB;MD60NFUzPCEQvF2= M4DUdHNCVkeHUh?=
SW13 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwNEC2NlYh|ryP M1HQWXNCVkeHUh?=
NCI-H1437 NYSxO4VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXDTWM2OD1yLkSwPFA2KM7:TR?= NY\OfW94W0GQR1XS
U-118-MG M2PsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfLTWM2OD1yLkSwPVA1KM7:TR?= MWTTRW5ITVJ?
NCI-H1734 M{PKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNEKwNVMh|ryP NYjIbIFTW0GQR1XS
HDLM-2 NFnNOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrhSlkyUUN3ME2wMlQzODN|IN88US=> NIrufJRUSU6JRWK=
AU565 NXL2bWlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjOTWM2OD1yLkSyOFY5KM7:TR?= M3nQUHNCVkeHUh?=
FADU MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3sWot5UUN3ME2wMlQzPjR7IN88US=> M4HHSXNCVkeHUh?=
OS-RC-2 MoKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNEOwPFMh|ryP M3vSXXNCVkeHUh?=
CAMA-1 NFvzW|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj3dYx7UUN3ME2wMlQ{PjJ4IN88US=> NWXxbXRVW0GQR1XS
MONO-MAC-6 M1T0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvucotYUUN3ME2wMlQ{QDR7IN88US=> MkX5V2FPT0WU
LB831-BLC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX5SXpKSzVyPUCuOFQ{PzFizszN NGm4cGdUSU6JRWK=
SW982 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S1dWlEPTB;MD60OFUzQCEQvF2= M16xRnNCVkeHUh?=
SCC-3 NHqwd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDjfopKUUN3ME2wMlQ1PTd7IN88US=> NV;kWHp{W0GQR1XS
C32 NEnWdVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHCeYxKSzVyPUCuOFUzOjlizszN M1fDd3NCVkeHUh?=
BFTC-909 Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwNEWyPVkh|ryP NW[yXmI1W0GQR1XS
MEG-01 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn3TWM2OD1yLkS1N|c{KM7:TR?= NEL2fJpUSU6JRWK=
M14 M3fx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNEW5O|kh|ryP NXPjR3V3W0GQR1XS
MPP-89 NVTjc|BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPKdIlKSzVyPUCuOFYzPTZizszN MoCwV2FPT0WU
HCC1937 NWjlZmlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDZTWM2OD1yLkS2N|g1KM7:TR?= M17hfHNCVkeHUh?=
SW837 M1XNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDZTJNuUUN3ME2wMlQ3PzJ{IN88US=> M4S4bHNCVkeHUh?=
DU-145 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DwRWlEPTB;MD60OlczQSEQvF2= Mne1V2FPT0WU
LB996-RCC NIPaSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln6TWM2OD1yLkS3NFU1KM7:TR?= NXXYNYZsW0GQR1XS
C8166 NY\V[XlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUWzbJJsUUN3ME2wMlQ4PCEQvF2= NFTUNJlUSU6JRWK=
MOLT-4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwNEe3N|Qh|ryP MoDnV2FPT0WU
DMS-53 M2fzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfCTWlKSzVyPUCuOFc5ODlizszN NW\PXJlwW0GQR1XS
TE-5 NYDRVI1vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\CTZhUUUN3ME2wMlQ5OzB3IN88US=> NIXSbW5USU6JRWK=
KYSE-520 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL5Rm5FUUN3ME2wMlQ5OzR|IN88US=> MoGwV2FPT0WU
Detroit562 NX\0OmFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD2TWM2OD1yLkS4PFYh|ryP NHTye3dUSU6JRWK=
SIMA MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnIfWZ2UUN3ME2wMlQ6PDF5IN88US=> MYXTRW5ITVJ?
NCI-H1651 M2L5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoqxTWM2OD1yLkS5Olch|ryP NHrSfIdUSU6JRWK=
HCC1599 NXX4c3puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP3TWM2OD1yLkS5PVU2KM7:TR?= MnXEV2FPT0WU
ABC-1 M2TNZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUWyOXRuUUN3ME2wMlUxPDl4IN88US=> MUXTRW5ITVJ?
CAL-33 NWjyZ45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDKT21[UUN3ME2wMlUxQDR2IN88US=> M2\BOnNCVkeHUh?=
OPM-2 Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHqbYFKSzVyPUCuOVA6OzdizszN MmnkV2FPT0WU
RPMI-7951 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPMTWM2OD1yLkWwPVU4KM7:TR?= MWXTRW5ITVJ?
HT-1080 NIW1d|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPoTWM2OD1yLkWxNVE6KM7:TR?= Moe2V2FPT0WU
LC4-1 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnFVXJKSzVyPUCuOVE1ODNizszN NUjwe45EW0GQR1XS
OVCAR-3 NHvjcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoriTWM2OD1yLkWxOVch|ryP MXXTRW5ITVJ?
CAPAN-1 M1vaRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7rTWM2OD1yLkWyNlg5KM7:TR?= NYO5NoREW0GQR1XS
SK-OV-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwNUK0N|Qh|ryP MXrTRW5ITVJ?
HuP-T3 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXG[YxiUUN3ME2wMlUzQDJ5IN88US=> Mn72V2FPT0WU
NCI-H838 NFvsVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T4bWlEPTB;MD61Nlg1QSEQvF2= M3HUfnNCVkeHUh?=
K5 M2H2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNUOyNFEh|ryP NUTNUpZiW0GQR1XS
CAL-72 M1TPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPVcndtUUN3ME2wMlU{Ozh5IN88US=> NF7KeIhUSU6JRWK=
NH-12 M2Ll[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoGwTWM2OD1yLkWzPVU6KM7:TR?= NV[4W4g6W0GQR1XS
SNB75 NEHoXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwNUW3N{DPxE1? NYDVTXZLW0GQR1XS
BPH-1 NVfvXod4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfFXlg2UUN3ME2wMlU3OzR2IN88US=> M2fFUXNCVkeHUh?=
NOMO-1 M1XDN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3UNGZKSzVyPUCuOVY{PzJizszN MXHTRW5ITVJ?
G-402 NYC1SHVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwNU[0PVkh|ryP NGfaSWFUSU6JRWK=
NCI-H2052 NV\YZ4JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2D0RmlEPTB;MD61Olc1OSEQvF2= Mkf5V2FPT0WU
RCM-1 M3W1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1KzSmlEPTB;MD61O|E3PiEQvF2= NVH2RZhJW0GQR1XS
COR-L279 MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3v5OGlEPTB;MD61O|E5PSEQvF2= NVG4SWlbW0GQR1XS
A253 M3PUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnDfnJGUUN3ME2wMlU4PTJ3IN88US=> MWfTRW5ITVJ?
SK-MM-2 NGDMV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNUe2O|kh|ryP NGKzNIFUSU6JRWK=
NCI-H1703 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nKXGlEPTB;MD61PVQzPyEQvF2= MoDZV2FPT0WU
UACC-257 NX\he4E1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NICyXZBKSzVyPUCuOVk1QDdizszN MoS2V2FPT0WU
KALS-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL3cpJrUUN3ME2wMlYxODFzIN88US=> MnLDV2FPT0WU
ES5 NFnOT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHCTWM2OD1yLk[wOFgh|ryP NIrQWlhUSU6JRWK=
MHH-CALL-2 NXnTfG5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\R[INGUUN3ME2wMlYxQDh6IN88US=> M4DzWHNCVkeHUh?=
ChaGo-K-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S4cGlEPTB;MD62NVIzQSEQvF2= MnPJV2FPT0WU
TGBC1TKB M2XpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfTTWM2OD1yLk[xPVgh|ryP NF\vUVdUSU6JRWK=
KU-19-19 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1m5[GlEPTB;MD62OFU5PiEQvF2= NF\FSZpUSU6JRWK=
COLO-684 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;FVnFWUUN3ME2wMlY2PjFzIN88US=> MlzNV2FPT0WU
LS-1034 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rIfGlEPTB;MD62OVgyQSEQvF2= NWDUS3Z3W0GQR1XS
RT-112 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwNk[1PFch|ryP NGDHc2tUSU6JRWK=
Capan-2 NYLPZ5VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fmOmlEPTB;MD62OlYzOiEQvF2= MV3TRW5ITVJ?
HSC-4 M4fSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7jTWM2OD1yLk[2Olk5KM7:TR?= NEHkR21USU6JRWK=
COLO-824 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwNke4NlMh|ryP MVPTRW5ITVJ?
NCI-H2170 M1O4R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfhbHFKSzVyPUCuOlgzPThizszN NYXC[25{W0GQR1XS
GDM-1 M3PNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELlVIVKSzVyPUCuOlg1QTRizszN MoLxV2FPT0WU
KP-4 NV;CRXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\jTWM2OD1yLk[5OVc{KM7:TR?= M3fjbHNCVkeHUh?=
VA-ES-BJ M4HBSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXIcohxUUN3ME2wMlY6QTh4IN88US=> NFPFd5BUSU6JRWK=
KM-H2 NHTSUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrsSlluUUN3ME2wMlcxODlzIN88US=> MX3TRW5ITVJ?
HH NWf2bmZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL5TWM2OD1yLkewOlYzKM7:TR?= M1zRenNCVkeHUh?=
DK-MG M{PiNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwN{GwNVYh|ryP NEjSbHFUSU6JRWK=
VM-CUB-1 M3zE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojDTWM2OD1yLkexNlU6KM7:TR?= NIDvU5JUSU6JRWK=
COLO-829 NV36V|BGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;STGlEPTB;MD63NVk5PSEQvF2= M1XZTnNCVkeHUh?=
OMC-1 NYX5T45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwN{KxNFQh|ryP NWfSUpF5W0GQR1XS
NB12 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLNTph{UUN3ME2wMlczPTB2IN88US=> NFm5PHNUSU6JRWK=
NCI-H28 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFftSWxKSzVyPUCuO|QxQDNizszN MX3TRW5ITVJ?
A673 M1zZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\LTWM2OD1yLke1NVc4KM7:TR?= NILYe3ZUSU6JRWK=
LB2241-RCC NUHET2RwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vO[mlEPTB;MD63OlA5PyEQvF2= MXXTRW5ITVJ?
CCRF-CEM NUPBPZU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwN{ewOVIh|ryP NIH2fZFUSU6JRWK=
NCI-H510A NETKUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXpcHd5UUN3ME2wMlc4OTh4IN88US=> MWfTRW5ITVJ?
SW48 NFrKboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj4OWZOUUN3ME2wMlc4OzN|IN88US=> NUfGVmdoW0GQR1XS
NCI-H2081 NEHBUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu1T2xKSzVyPUCuO|gyPDdizszN M3j5S3NCVkeHUh?=
RMG-I NVr2NYRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fK[WlEPTB;MD63PFIyOiEQvF2= MXLTRW5ITVJ?
LU-99A M4XBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP0ZoVKSzVyPUCuO|g1OTNizszN MljNV2FPT0WU
KP-N-YS M4jo[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\GdGlEPTB;MD63PFkzOSEQvF2= MlPuV2FPT0WU
MDA-MB-231 NYXDV21tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPW[GdkUUN3ME2wMlgxOTNzIN88US=> NXnOPWlUW0GQR1XS
U031 MljsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwOEG0NlMh|ryP NGCzfYhUSU6JRWK=
EVSA-T MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\WfWlEPTB;MD64NVY4OiEQvF2= M1LNfnNCVkeHUh?=
MDA-MB-157 NW\3[oZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXOTWM2OD1yLkiyNlcyKM7:TR?= MUTTRW5ITVJ?
EHEB MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vVfWlEPTB;MD64NlI4PiEQvF2= MlfPV2FPT0WU
KINGS-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwOEK1OVUh|ryP Mnm1V2FPT0WU
23132-87 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n6UWlEPTB;MD64Nlg1OyEQvF2= MYjTRW5ITVJ?
EFO-21 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK0TWM2OD1yLki0NFg6KM7:TR?= M4X3VnNCVkeHUh?=
DOK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELKZ5lKSzVyPUCuPFQ5KM7:TR?= NILZSppUSU6JRWK=
NCI-H2171 M1v1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLjWnZTUUN3ME2wMlg1QTZizszN NUjFU4t[W0GQR1XS
NCI-SNU-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjQfI9GUUN3ME2wMlg2PTdizszN NVy3VIQ6W0GQR1XS
SK-N-DZ Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwOEW5OFMh|ryP NYLTeVVHW0GQR1XS
SNU-C2B MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrGTolKSzVyPUCuPFY5ODFizszN MVjTRW5ITVJ?
CP66-MEL MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXNTWM2OD1yLki3NVEh|ryP MlHRV2FPT0WU
SN12C NGXGTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwOEi2N|ch|ryP NHvkOmJUSU6JRWK=
A172 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS4TWM2OD1yLki4Olk5KM7:TR?= MWjTRW5ITVJ?
NCI-H2347 M2Pzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwOEi3OVMh|ryP NXrPboR5W0GQR1XS
NCI-H2228 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwOEmzN|kh|ryP MYLTRW5ITVJ?
SNU-387 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrtUVBCUUN3ME2wMlkxOjZ2IN88US=> MUPTRW5ITVJ?
SK-MEL-24 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jKSGlEPTB;MD65NVM1PCEQvF2= MVLTRW5ITVJ?
MDA-MB-468 NYXsS|RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7UbHY1UUN3ME2wMlkyPzNizszN MmDoV2FPT0WU
NCI-H1694 M1vNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjlNIFKSzVyPUCuPVE5PzZizszN M{HxWXNCVkeHUh?=
CCF-STTG1 NIfGXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnSemVwUUN3ME2wMlkzPjN5IN88US=> M3TqRnNCVkeHUh?=
K052 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jpOWlEPTB;MD65OFA1PyEQvF2= MnjVV2FPT0WU
NCI-H446 NH7M[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwOUWwNUDPxE1? M33PfnNCVkeHUh?=
MFE-280 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\JT5pvUUN3ME2wMlk3OjlzIN88US=> MmHQV2FPT0WU
KU812 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HvemlEPTB;MD65PVM5QSEQvF2= NXvuT5F2W0GQR1XS
MDA-MB-361 M{DJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTCTWM2OD1yLkm5O|c4KM7:TR?= NHTy[GNUSU6JRWK=
Raji MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HoVmlEPTB;MT6wNlI3PyEQvF2= MUnTRW5ITVJ?
TE-6 NU\lbZA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[2VWlEPTB;MT6wN|U3PiEQvF2= NVfpSI9kW0GQR1XS
CAL-148 Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjMeG1KSzVyPUGuNFQ1PDNizszN NUjDbWdkW0GQR1XS
NCI-H1963 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjx[nNKSzVyPUGuNFQ2PTNizszN M{H0SXNCVkeHUh?=
SK-N-AS M1HjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofTTWM2OD1zLkC0Olg2KM7:TR?= MmWxV2FPT0WU
RERF-LC-MS MkHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHznPIRKSzVyPUGuNFY{PDlizszN M3zrWXNCVkeHUh?=
BEN MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjlSpZKSzVyPUGuNFcyOzdizszN NYHMeFhnW0GQR1XS
CAS-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XucWlEPTB;MT6wPVEzOyEQvF2= MXvTRW5ITVJ?
SW780 M1[z[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTFwMEmxPFEh|ryP NEL1PWpUSU6JRWK=
LU-65 NHyxeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPiVlZKSzVyPUGuNFk1OSEQvF2= MlLnV2FPT0WU
D-283MED NYTyV2lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfUUnVKSzVyPUGuNVIzPzJizszN M2S5W3NCVkeHUh?=
HCC2157 NEjHNWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPaXGFFUUN3ME2xMlE{PjR{IN88US=> MYDTRW5ITVJ?
RCC10RGB NY\JfmlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFwMUSwNFYh|ryP NITQTmNUSU6JRWK=
PLC-PRF-5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDqTWM2OD1zLkG1NlI6KM7:TR?= NGj5bJRUSU6JRWK=
H4 M4Tkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nrU2lEPTB;MT6xOVQ{QSEQvF2= NFi0eFBUSU6JRWK=
TUR NWXZUHFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPaV21CUUN3ME2xMlE2PzV{IN88US=> M4fpeHNCVkeHUh?=
NCI-H2141 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\QTWM2OD1zLkG4PVQ3KM7:TR?= NH:0UFFUSU6JRWK=
PFSK-1 NWTyNppxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrWUGFWUUN3ME2xMlIxPTN{IN88US=> MnXwV2FPT0WU
SK-MEL-28 M1nKd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17UZmlEPTB;MT6yN|IzOSEQvF2= MonRV2FPT0WU
SCC-9 NIPRWGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LiWmlEPTB;MT6yN|Y3PSEQvF2= MoP0V2FPT0WU
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COLO-800 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkG3TWM2OD13LkG5N|Q6KM7:TR?= MnvQV2FPT0WU
NCI-H1755 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTVwMkOwNlch|ryP MmPpV2FPT0WU
KMS-12-PE M1vnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfybVZsUUN3ME21MlM2ODh3IN88US=> M1\yeXNCVkeHUh?=
HCC1954 M1ixRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHlPXBWUUN3ME21Mlg2QTdzIN88US=> M1;5ZXNCVkeHUh?=
NCI-H187 NFS4XlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PudGlEPTB;NT65Nlk5QSEQvF2= MUXTRW5ITVJ?
LU-165 NW\JU2ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Txd2lEPTB;NT65PVAxOiEQvF2= M{TxRnNCVkeHUh?=
YAPC MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTVwOUmwOlgh|ryP M3PC[HNCVkeHUh?=
LU-139 NH\qblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTZwMEizOlgh|ryP NWnNVG1yW0GQR1XS
D-502MG MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HtZWlEPTB;Nj6zNlA1PyEQvF2= M3mwSXNCVkeHUh?=
IST-SL1 NYPDS4NZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXrTWM2OD14LkWzPVQ5KM7:TR?= NH\GPYxUSU6JRWK=
DG-75 NEfPV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe2cplLUUN3ME22Mlg5Pzh4IN88US=> M2nXc3NCVkeHUh?=
NCI-H1155 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe4WFlKSzVyPU[uPVU2QDFizszN M1LRcHNCVkeHUh?=
EFE-184 NFnvbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojtTWM2OD15LkOxOlk2KM7:TR?= NYXsfIJDW0GQR1XS
AsPC-1 M3nrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zZbWlEPTB;Nz60PFgxPyEQvF2= MX7TRW5ITVJ?
SW948 M2\hdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTdwNUizPVUh|ryP NYXUdXRWW0GQR1XS
NCI-H524 NX;vd|Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fIeGlEPTB;OT61PFYzQCEQvF2= M3[5RnNCVkeHUh?=
KOSC-2 NV3Fe2RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrqc4Q{UUN3ME25MlYzQDN2IN88US=> NWXWXlY4W0GQR1XS
T-24 NULMdVFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFraXHlKSzVyPUmuPVQ1OTVizszN MnXPV2FPT0WU
NCI-H748 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFyLk[zPVch|ryP MkLFV2FPT0WU
NCI-H23 M17l[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TZfGlEPTB;MUCuOlQ1OiEQvF2= NITCVldUSU6JRWK=
UACC-812 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfNTWM2OD1zMT63NVch|ryP NHfVcIxUSU6JRWK=
SCLC-21H NXfIU4xYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PTVWlEPTB;MUKuNVU2OSEQvF2= MXrTRW5ITVJ?
NCI-SNU-16 NUfzVZB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G2fmlEPTB;MUOuNVI2QCEQvF2= MYjTRW5ITVJ?
HD-MY-Z MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD5[JRUUUN3ME2xOE43OzZ|IN88US=> MkLTV2FPT0WU
SK-N-FI M4\KVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT0dmR5UUN3ME2xOE45QTF{IN88US=> NULIeYxKW0GQR1XS
LB647-SCLC M3vIRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljFTWM2OD1zNT63NVk2KM7:TR?= NEfpfIZUSU6JRWK=
NCI-H345 M2DB[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF5LkO0N{DPxE1? MYXTRW5ITVJ?
NCI-H1563 MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF6Lke2NFEh|ryP M1ewdXNCVkeHUh?=
RL MoWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XOb2lEPTB;MkGuNlY2PiEQvF2= M1nwNHNCVkeHUh?=
KY821 M17ZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHyxSW5KSzVyPUKyMlA2PTNizszN M33iW3NCVkeHUh?=
JVM-3 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW2bVh3UUN3ME2yOU4xPDF|IN88US=> NETFc3NUSU6JRWK=
NCI-H1793 M{\pTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4joRmlEPTB;MkiuOVQ6QSEQvF2= NYe2c2RyW0GQR1XS
LU-134-A NXi4SJQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTNyLkKwN|ch|ryP MXrTRW5ITVJ?
NCI-H1395 NGrQdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkWzTWM2OD1|Mj6yOFMyKM7:TR?= M{DmfXNCVkeHUh?=
NCI-H1993 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN{LkiyNVgh|ryP MkDiV2FPT0WU
P31-FUJ NIHGTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPyOlFKSzVyPUOzMlQ5QTlizszN NGTiZ2NUSU6JRWK=
LS-513 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknXTWM2OD1|NT64PFc6KM7:TR?= NFPV[plUSU6JRWK=
SK-MEL-1 M3nGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTRyLkO0PVkh|ryP M4TJV3NCVkeHUh?=
SW684 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTR|Lkm2OlEh|ryP MWXTRW5ITVJ?
COR-L88 NUHSb4t{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTR2LkC2OlUh|ryP M3rEZnNCVkeHUh?=
NCI-H889 M1fQUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjkTWM2OD12NT6wNFg4KM7:TR?= MY\TRW5ITVJ?
TALL-1 NYjSXpo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfLTWM2OD12Nj6xNVk6KM7:TR?= MkjyV2FPT0WU
KARPAS-299 NFzhSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTR5LkG5PVMh|ryP MUXTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin D1 / p27 Kip1 ; 

PubMed: 28382170     


Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1.

p-Cyclin D1 ; 

PubMed: 28035994     


Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control;

p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; 

PubMed: 28035994     


Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;

28382170 28035994
Growth inhibition assay
Cell proliferation ; 

PubMed: 28035994     


Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control.

Cell viability; 

PubMed: 21368880     


H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D. 

28035994 21368880
In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
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Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
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  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID