Obatoclax Mesylate (GX15-070)

Name: Obatoclax Mesylate (GX15-070)
Brand: Selleck Chemicals
SKU: S1057
Rating: 5 (104 reviews)

For research use only.

Catalog No.S1057

104 publications

Obatoclax Mesylate (GX15-070) Chemical Structure

CAS No. 803712-79-0

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with K_i of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Selleck's Obatoclax Mesylate (GX15-070) has been cited by 104 publications

Cancer Cell, 2019, 36(1):68-83

PubMed: 31257073 ( click the link to review the publication )

Nature, 2017, 551(7679):247-250

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Cell, 2010, 20;142(4):590-600.

PubMed: 20723759 ( click the link to review the publication )

Transl Oncol, 2021, 14(8):101116

PubMed: 33975180 ( click the link to review the publication )

Biomaterials, 2020, 232:119709

PubMed: 31896513 ( click the link to review the publication )

Int J Mol Sci, 2020, 5;21(5) pii: E1773

PubMed: 32150830 ( click the link to review the publication )

Invest New Drugs, 2020, 4

PubMed: 32367199 ( click the link to review the publication )

NPJ Breast Cancer, 2020, 6:30

PubMed: 32715085 ( click the link to review the publication )

Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.04.011

PubMed: 31155509 ( click the link to review the publication )

Int J Mol Sci, 2019, 20(6)

PubMed: 30875757 ( click the link to review the publication )

Front Microbiol, 2019, 10:2236

PubMed: 31636613 ( click the link to review the publication )

Prostate, 2019, 79(11):1347-1359

PubMed: 31228231 ( click the link to review the publication )

Cancers (Basel), 2018, 10(12)

PubMed: 30563080 ( click the link to review the publication )

Cell Death Discov, 2018, 4:107

PubMed: 30479840 ( click the link to review the publication )

Cell Death Dis, 2018, 92(10)

PubMed: 23640461 ( click the link to review the publication )

Antioxidants (Basel), 2018, 10.3390/antiox7110150

PubMed: 30373097 ( click the link to review the publication )

BMC Cancer, 2018, 18(1):965

PubMed: 30305055 ( click the link to review the publication )

J Clin Invest, 2017, 127(1):153-168

PubMed: 27893461 ( click the link to review the publication )

Cancer Res, 2017, 77(13):3513-3526

PubMed: 28522750 ( click the link to review the publication )

Cancer Res, 2017, 10.1158/0008-5472.CAN-16-3424

PubMed: ( click the link to review the publication )

Genome Med, 2017, 9(1):40

PubMed: 28446242 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):52

PubMed: 28403890 ( click the link to review the publication )

Arch Toxicol, 2017, 91(5):2191-2208

PubMed: 27807597 ( click the link to review the publication )

FEBS J, 2017, 284(2):222-236

PubMed: 27860276 ( click the link to review the publication )
Antimicrob Agents Chemother, 2017, 61(3)

PubMed: 27993855 ( click the link to review the publication )

Electrophoresis, 2017, 10.1002/elps.201600447

PubMed: 28608427 ( click the link to review the publication )

J Exp Med, 2017, 214(6):1691-1710

PubMed: 28450382 ( click the link to review the publication )

Oncotarget, 2017, 8(5):8670-8678

PubMed: 28055968 ( click the link to review the publication )

Viruses, 2017, 9(10)

PubMed: 28946654 ( click the link to review the publication )

Blood, 2016, 6;128(14):1834-1844

PubMed: 27465916 ( click the link to review the publication )

Nat Commun, 2016, 7:11190

PubMed: 27048913 ( click the link to review the publication )

Autophagy, 2016, 2;12(6):999-1014

PubMed: 27124102 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(21):5370-5382

PubMed: 27178741 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2016, 113(46):13150-13155

PubMed: 27799526 ( click the link to review the publication )

ACS Appl Mater Interfaces, 2016, 8(21):13218-31

PubMed: 27160664 ( click the link to review the publication )

Antiviral Res, 2016, 126:69-80

PubMed: 26738783 ( click the link to review the publication )

Cancer Cell Int, 2016, 16:27

PubMed: 27042160 ( click the link to review the publication )

Int J Oncol, 2016, 49(3):953-60

PubMed: 27572939 ( click the link to review the publication )

Oncotarget, 2016, 7(3):3520-32

PubMed: 26657288 ( click the link to review the publication )

Tumour Biol, 2016, 37(8):10839-49

PubMed: 26880588 ( click the link to review the publication )

Oncotarget, 2016, 7(50):82013-82027

PubMed: 27852038 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2357-2369

PubMed: 27512118 ( click the link to review the publication )

Oncotarget, 2016, 7(35):56253-56265

PubMed: 27494845 ( click the link to review the publication )

Oncotarget, 2016,

PubMed: 26910910 ( click the link to review the publication )

Oncotarget, 2016, 8(36):60060-60079

PubMed: 28947954 ( click the link to review the publication )

Oncotarget, 2016, 7(23):34453-71

PubMed: 27144341 ( click the link to review the publication )

Nat Chem Biol, 2015, 10.1038/nchembio.1986

PubMed: 26656090 ( click the link to review the publication )

Genes Dev, 2015, 29(20):2140-52

PubMed: 26494789 ( click the link to review the publication )
Int J Cancer, 2015, 137(12):2959-70

PubMed: 26096065 ( click the link to review the publication )

Cancer Lett, 2015, 10.1016/j.canlet.2015.05.008

PubMed: 25979228 ( click the link to review the publication )

Cell Death Dis, 2015, 6:e2014

PubMed: 26658189 ( click the link to review the publication )

Mol Oncol, 2015, 9(2):409-21

PubMed: 25308513 ( click the link to review the publication )

Mol Oncol, 2015, 9(2):409-21

PubMed: ( click the link to review the publication )

J Biol Chem, 2015, 290(34):20841-55

PubMed: 26124276 ( click the link to review the publication )

Cancer Cell Int, 2015, 15:97

PubMed: 26464561 ( click the link to review the publication )

Int J Oncol, 2015, 46(4):1844-8

PubMed: 25647738 ( click the link to review the publication )

BMC Cancer, 2015, 15:919

PubMed: 26585594 ( click the link to review the publication )

BMC Cancer, 2015, 15:568

PubMed: 26231047 ( click the link to review the publication )

Open Biol, 2015, 5(3)

PubMed: 25761368 ( click the link to review the publication )

Mol Cells, 2015, 38(3):279-84

PubMed: 25666350 ( click the link to review the publication )

Oral Dis, 2015,

PubMed: 25482163 ( click the link to review the publication )

Cell Biochem Funct, 2015, 33(5):334-40

PubMed: 26178811 ( click the link to review the publication )

Anticancer Drugs, 2015, 26(3):331-42

PubMed: 25521557 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26008975 ( click the link to review the publication )

Arch Pharm Chem Life Sci, 2015, 348: 1-11

PubMed: 25641608 ( click the link to review the publication )

J Pharm Pharmacol, 2015, 67(11):1575-84

PubMed: 26255619 ( click the link to review the publication )

Oncotarget, 2015, 6(40):42445-67

PubMed: 26636651 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 25749045 ( click the link to review the publication )

Cancer Lett, 2014, 348(1-2):20-8

PubMed: 24534203 ( click the link to review the publication )

Endocr Relat Cancer, 2014, 21(5):755-67

PubMed: 25012986 ( click the link to review the publication )

Oral Oncol, 2014, 50(2):120-7

PubMed: 24216166 ( click the link to review the publication )

Antimicrob Agents Chemother, 2014, 58(7):3689-96

PubMed: 24752266 ( click the link to review the publication )
Biochem Pharmacol, 2014, 92(1):55-61

PubMed: 25107702 ( click the link to review the publication )

J Biol Chem, 2014, 289(38):26481-91

PubMed: 25096574 ( click the link to review the publication )

Exp Cell Res, 2014, 322(1):217-25

PubMed: 24355809 ( click the link to review the publication )

Life Sci, 2014, 10.1016/j.lfs.2014.07.006

PubMed: 25066930 ( click the link to review the publication )

Oncol Rep, 2014, 32(6):2789-94

PubMed: 25333301 ( click the link to review the publication )

J Cell Biochem, 2014, 115(9):1624-35

PubMed: 24788582 ( click the link to review the publication )

PLoS One, 2014, 9(11):e111927

PubMed: 25409302 ( click the link to review the publication )

PLoS One, 2014, 9(10):e111146

PubMed: 25343454 ( click the link to review the publication )

PLoS One, 2014, 9(9):e106571

PubMed: 25192188 ( click the link to review the publication )

Genes Cancer, 2014, 5(11-12):445-59

PubMed: 25568669 ( click the link to review the publication )

Erasmus University Rotterdam, 2014, 978-94-6259-077-9

PubMed: http://repub.eur.nl/pub/50827/ ( click the link to review the publication )

Assay Drug Dev Technol, 2014, 12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2013, 110(11):4321-6

PubMed: 23447565 ( click the link to review the publication )

Int J Cancer, 2013, 133(8):1813-24

PubMed: 23580240 ( click the link to review the publication )

Cell Death Dis, 2013,

PubMed: 23681223 ( click the link to review the publication )

Cell Death Dis, 2013, 4:e742

PubMed: 23887633 ( click the link to review the publication )

Mol Cancer Ther, 2013, 12(4):448-59

PubMed: 23395885 ( click the link to review the publication )

J Immunol, 2013, 190(9):4621-6

PubMed: 23547112 ( click the link to review the publication )

Apoptosis, 2013, 18(10):1163-74

PubMed: 23887890 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2013, 49(4):609-18

PubMed: 23668615 ( click the link to review the publication )

Cancer Biol Ther, 2013, 14(10):982-96

PubMed: 24025251 ( click the link to review the publication )

Exp Cell Res, 2013, 319(10):1443-50

PubMed: 23416067 ( click the link to review the publication )

PLoS One, 2013, 8(2):e55982

PubMed: 23418490 ( click the link to review the publication )

Helsinki Metropolia University, 2013, Jens Desloovere

PubMed: ( click the link to review the publication )
Cancer Res, 2012, 72(12):3069-79

PubMed: 22525702 ( click the link to review the publication )

Oncogene, 2012, 32(37):4331-42

PubMed: 23085751 ( click the link to review the publication )

Cancer Lett, 2012, 339(2):288-97

PubMed: 23200668 ( click the link to review the publication )

Cell Death Dis, 2012, 3:e351

PubMed: 22825469 ( click the link to review the publication )

Cell Death Dis, 2012, 3:e299

PubMed: 22513873 ( click the link to review the publication )

Toxicol Sci, 2012, 128(1):79-91

PubMed: 22491427 ( click the link to review the publication )

Cancer Res, 2011, 71(13):4494-505

PubMed: 21555370 ( click the link to review the publication )

BMC Cancer, 2011, 11:24

PubMed: 21247487 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with K_i of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Features

Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.

Targets

Bcl-2 ^[1]
(Cell-free assay)

0.22 μM(Ki)

In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. ^[1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. ^[2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
KARPAS-45	NFy5NohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml\JTWM2OD1yLkCwNFA{OTdizszN	NULjcGQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SK-MEL-30	NHPGUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3;3ZmlEPTB;MD6wNFA{PTVizszN	M2G4VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NALM-6	MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTBwMECwN\|U3KM7:TR?=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
KYSE-450	M3qzWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEC3SFBKSzVyPUCuNFAxPDZ7IN88US=>	M4\uSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
BHY	M{j2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLub4JKSzVyPUCuNFAxPjBzIN88US=>	M2C2SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
GR-ST	NF7ud\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfuZ\|FMUUN3ME2wMlAxODZ2ODFOwG0>	NYXmWoZYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
786-0	M3rTWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1nSUWlEPTB;MD6wNFA4PzZizszN	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
C-33-A	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlrITWM2OD1yLkCwNFg1QCEQvF2=	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
BHT-101	NHz2SY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnj0TWM2OD1yLkCwNVA3KM7:TR?=	NXzo[JJ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
EB2	MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{DRWGlEPTB;MD6wNFEyQCEQvF2=	Mmr0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
G-361	M4nhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTBwMECxNlQh\|ryP	M{HTZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
KE-37	NFO1U3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFTzfGtKSzVyPUCuNFAyOjhizszN	NHiwbIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MHH-PREB-1	M3LhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4f2[GlEPTB;MD6wNFE1KM7:TR?=	NEGwZ5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MCF7	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\MbYVJUUN3ME2wMlAxOTV7IN88US=>	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
LOUCY	NHK2WHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3i4e2lEPTB;MD6wNFE4PSEQvF2=	NVHF[JRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
EW-7	NHvOW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjufYdKSzVyPUCuNFAyPzVizszN	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
KYSE-510	NHO5VYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jCPGlEPTB;MD6wNFI{OyEQvF2=	NYXiOVNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SK-MEL-3	MkHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUjJR\|UxRTBwMECyOlQh\|ryP	NH;PRm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
HAL-01	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MofBTWM2OD1yLkCwNlk4KM7:TR?=	Mm[xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
HCC2998	M1LsfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3TXNGlEPTB;MD6wNFM{PSEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
A375	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIGxdXdKSzVyPUCuNFA{PSEQvF2=	M1HISFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
MZ7-mel	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFHFTG5KSzVyPUCuNFA{QTlizszN	NHLyXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SH-4	M2D1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn[5TWM2OD1yLkCwOFE4KM7:TR?=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HT-144	NITxdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTBwMEC0N{DPxE1?	MlPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
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UACC-62	NYjVNFA{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3eyO2lEPTB;MD6zNFI1OSEQvF2=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
TE-11	MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwM{CyOFkh\|ryP	MlTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
MKN1	M4HlZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4X5ZWlEPTB;MD6zNFM3KM7:TR?=	MnP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
KS-1	NI\abZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX3JR\|UxRTBwM{C1NlYh\|ryP	MlT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
GCIY	MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlryTWM2OD1yLkOxNFAzKM7:TR?=	NW\xPJlvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
OVCAR-5	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGPxTndKSzVyPUCuN\|EyODZizszN	NEHGNlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
U-266	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlX0TWM2OD1yLkOxNVQ4KM7:TR?=	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
Calu-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo\ETWM2OD1yLkOxNlg6KM7:TR?=	NGfk[4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SK-LMS-1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHjuc4tKSzVyPUCuN\|E1OjlizszN	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
COLO-741	NELmZXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mle1TWM2OD1yLkOxOlE1KM7:TR?=	NUXE[Ys1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
RPMI-8226	M{npcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXsV3FKSzVyPUCuN\|E3PDFizszN	MlfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
KM12	NHT3Z4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVvJR\|UxRTBwM{G4N{DPxE1?	NHm5UXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
NMC-G1	M2LnVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnH3TWM2OD1yLkOxPFYh\|ryP	NFXUOnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SJRH30	NWqxe5c{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHzXcnNKSzVyPUCuN\|IxPTJizszN	Mof5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
COR-L105	NXK3dpR2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1LuWmlEPTB;MD6zNlIyQCEQvF2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
IM-9	NFjPVnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYXWSJZRUUN3ME2wMlM{ODJzIN88US=>	MnvEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
TE-12	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrMR3FbUUN3ME2wMlM{OzF5IN88US=>	M3zxSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
KG-1	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWXCfVFjUUN3ME2wMlM{PDN{IN88US=>	Mn7yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
U251	M2DB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fWbGlEPTB;MD6zN\|Q2PiEQvF2=	NVzIUoxyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
EFO-27	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XIcWlEPTB;MD6zN\|k2OSEQvF2=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
EW-24	NETGWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWP1codXUUN3ME2wMlM{QTh2IN88US=>	NYnTTIFFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SF295	Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV\GUGRkUUN3ME2wMlM{QTl7IN88US=>	NHvlSIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MC-IXC	NHPSO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTBwM{S1JO69VQ>?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NCI-H2405	NHi5dFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPtTWM2OD1yLkO0O\|MzKM7:TR?=	Mnm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H2009	NI\iOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX2wNHpNUUN3ME2wMlM1PzN7IN88US=>	M2PRdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
LB1047-RCC	NWSw[4FVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnhd4M2UUN3ME2wMlM2QDF3IN88US=>	NY\1WoNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KNS-81-FD	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4XPNWlEPTB;MD6zOlY3PyEQvF2=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HOP-92	NGTvVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MofsTWM2OD1yLkO2PFMh\|ryP	Ml;LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
L-428	NIqwZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnHqTWM2OD1yLkO3NFE3KM7:TR?=	NF7JdJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
C3A	MnnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYTufXpwUUN3ME2wMlM4Ozd7IN88US=>	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NCI-H1792	M3\YNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYnJR\|UxRTBwM{e2OVUh\|ryP	NFvrdY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
HuH-7	M3zTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXL4coN7UUN3ME2wMlM4QTFizszN	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
AGS	Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEGz[mdKSzVyPUCuN\|g3OzhizszN	M4jSbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
HT-1197	NFzHZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVi0TmpRUUN3ME2wMlM6PDZizszN	NFOxNFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
CGTH-W-1	Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXLUcYpHUUN3ME2wMlM6QTF\|IN88US=>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
KNS-42	NVntO5ZIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEfMO4JKSzVyPUCuOFAxPDVizszN	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HuO-3N1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo[5TWM2OD1yLkSwNFU2KM7:TR?=	Mlu2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
VMRC-RCZ	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnH4TWM2OD1yLkSwN\|A{KM7:TR?=	NILSSFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SW954	M3;PeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH\Me2JKSzVyPUCuOFA{OzVizszN	NXXBdGJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
MES-SA	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFy3OG1KSzVyPUCuOFA2ODVizszN	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
Ca-Ski	MlzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mk\vTWM2OD1yLkSwOVI1KM7:TR?=	NUXoVmN4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SW13	M2Dkcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnfKTWM2OD1yLkSwOlI3KM7:TR?=	Ml;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H1437	NGH0PXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2\uTmlEPTB;MD60NFgxPSEQvF2=	M3\xTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
U-118-MG	NHS0e3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1nVSmlEPTB;MD60NFkxPCEQvF2=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NCI-H1734	NVfKZWRTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NW\jU4pvUUN3ME2wMlQzODF\|IN88US=>	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HDLM-2	MmXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTBwNEKwN\|Mh\|ryP	MoPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
AU565	NF;nfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTBwNEK0Olgh\|ryP	NIi4bWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
FADU	NG\nNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIqyVZlKSzVyPUCuOFI3PDlizszN	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
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M14	M1XncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIDkTYlKSzVyPUCuOFU6PzlizszN	NHLOPYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MPP-89	M3\ncGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnyzTWM2OD1yLkS2NlU3KM7:TR?=	NEO1Uog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
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DU-145	MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYL3OGJKUUN3ME2wMlQ3PzJ7IN88US=>	MnTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
LB996-RCC	NWnlOY82T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{S5UWlEPTB;MD60O\|A2PCEQvF2=	M1XsZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
C8166	NIPvT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmX2TWM2OD1yLkS3OEDPxE1?	NH\mbGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MOLT-4	NY\kWoxHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYLFeIl1UUN3ME2wMlQ4PzN2IN88US=>	MoHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
DMS-53	MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXjGNYpPUUN3ME2wMlQ4QDB7IN88US=>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
TE-5	M4nESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX;JR\|UxRTBwNEizNFUh\|ryP	NV\L[mNjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KYSE-520	NXrJWWtMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUXJR\|UxRTBwNEizOFMh\|ryP	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
Detroit562	NGTNWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4jnTGlEPTB;MD60PFg3KM7:TR?=	NWfjXJJoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SIMA	M1rmWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTBwNEm0NVch\|ryP	MlTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H1651	MlfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHHSSFRKSzVyPUCuOFk3PyEQvF2=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HCC1599	MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml7hTWM2OD1yLkS5PVU2KM7:TR?=	NX;xdlRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
ABC-1	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NE\3O2hKSzVyPUCuOVA1QTZizszN	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
CAL-33	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTBwNUC4OFQh\|ryP	M2PyRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
OPM-2	M4Xi[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk\JTWM2OD1yLkWwPVM4KM7:TR?=	NET1SWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
RPMI-7951	Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlLWTWM2OD1yLkWwPVU4KM7:TR?=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HT-1080	NXjhW283T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnHmTWM2OD1yLkWxNVE6KM7:TR?=	NEewbog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
LC4-1	M1;3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnizTWM2OD1yLkWxOFA{KM7:TR?=	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
OVCAR-3	Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnxempKSzVyPUCuOVE2PyEQvF2=	NVnZT3RvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
CAPAN-1	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTBwNUKyPFgh\|ryP	NGm3[FU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SK-OV-3	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWXLOWt2UUN3ME2wMlUzPDN2IN88US=>	NUjxVZZvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HuP-T3	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkW4TWM2OD1yLkWyPFI4KM7:TR?=	M1;kUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H838	M2LuSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUK0XIl3UUN3ME2wMlUzQDR7IN88US=>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
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CAL-72	Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1LMRWlEPTB;MD61N\|M5PyEQvF2=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NH-12	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjBOmhKSzVyPUCuOVM6PTlizszN	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
SNB75	M3XFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHmOmNiUUN3ME2wMlU2PzNizszN	NETseWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
BPH-1	NVPqZ2doT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mnu0TWM2OD1yLkW2N\|Q1KM7:TR?=	NFSxc5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
NOMO-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLYVVhTUUN3ME2wMlU3Ozd{IN88US=>	Mn7iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
G-402	MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX3JR\|UxRTBwNU[0PVkh\|ryP	M2K2clxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H2052	NUHBXYx3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NW\peW06UUN3ME2wMlU3PzRzIN88US=>	NEmwXZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
RCM-1	NXnXVmpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2C1ZWlEPTB;MD61O\|E3PiEQvF2=	M1;id\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
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LB647-SCLC	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTF3LkexPVUh\|ryP	M4SxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H345	M4P5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoHQTWM2OD1zNz6zOFMh\|ryP	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NCI-H1563	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4HsR2lEPTB;MUiuO\|YxOSEQvF2=	M2\QPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
RL	NWjhVoo2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XnOmlEPTB;MkGuNlY2PiEQvF2=	NXzXXlQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KY821	Mkf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUTBU3dGUUN3ME2yNk4xPTV\|IN88US=>	M1zDUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
JVM-3	M4izcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYPwS2MxUUN3ME2yOU4xPDF\|IN88US=>	NH7F[IU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
NCI-H1793	NXHxVG11T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnHETWM2OD1{OD61OFk6KM7:TR?=	NVK4OHQ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
LU-134-A	NYfidpJpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHnwRoRKSzVyPUOwMlIxOzdizszN	M1nGTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H1395	MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjCbWtKSzVyPUOyMlI1OzFizszN	M2TkZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H1993	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MojYTWM2OD1\|Mj64NlE5KM7:TR?=	MnjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
P31-FUJ	NFTZ[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXTibpRVUUN3ME2zN{41QDl7IN88US=>	NIrDe3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
LS-513	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NY\sbYQ4UUN3ME2zOU45QDd7IN88US=>	MlrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
SK-MEL-1	M{HreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3nqNGlEPTB;NECuN\|Q6QSEQvF2=	NFuzU2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SW684	NIKxcWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{DHZ2lEPTB;NEOuPVY3OSEQvF2=	M3KxbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
COR-L88	MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTR2LkC2OlUh\|ryP	M37rWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H889	NV\IeoR4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYDJR\|UxRTR3LkCwPFch\|ryP	MkDaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
TALL-1	M3rPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjQR3pKSzVyPUS2MlEyQTlizszN	NEDlN\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
KARPAS-299	MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1HacWlEPTB;NEeuNVk6OyEQvF2=	NH3velA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cyclin D1 / p27 Kip1 ; PubMed: 28382170 Theranostics Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1. p-Cyclin D1 ; PubMed: 28035994 Int J Mol Sci Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control; p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; PubMed: 28035994 Int J Mol Sci Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;	28382170 28035994
Growth inhibition assay	Cell proliferation ; PubMed: 28035994 Int J Mol Sci Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control. Cell viability; PubMed: 21368880 Cell Death Dis H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D.	28035994 21368880

In vivo

Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. ^[1]

Protocol

Kinase Assay:^[1]	- Collapse Bcl-2 Binding affinity calculation: A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. ^[4] As a control in determining the reliability of the calculation, predicted binding affinities K_i) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:^[2]	- Collapse Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) Concentrations: ~10 μM Incubation Time: 48-72 hours Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 10⁴ per well for HMCLs or 5~10 × 10³ for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined. (Only for Reference)
Animal Research:^[1]	- Collapse Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used. Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg Administration: Administered intravenously (tail vein) once a day (Only for Reference)

References

[4] Naim M, et al. J Chem Inf Model, 2007, 47(1), 122-133.

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Solubility (25°C)

In vitro	DMSO	83 mg/mL (200.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Obatoclax Mesylate (GX15-070) SDF

Molecular Weight	413.49
Formula	C₂₀H₁₉N₃O.CH₄O₃S
CAS No.	803712-79-0
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00438178	Completed	Drug: Obatoclax mesylate (GX15-070MS)	Hematological Malignancies	Gemin X\|Teva Pharmaceutical Industries	October 2005	Phase 1
NCT00600964	Completed	Drug: GX15-070MS	Chronic Lymphocytic Leukemia	Gemin X\|Teva Pharmaceutical Industries	September 2004	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

Pan Bcl-2 Inhibitor

ABT-737 : Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.
Most Potent Bcl-2 Inhibitor

ABT-263 (Navitoclax) : Bcl-xL, K_i≤ 0.5 nM; Bcl-2, K_i≤ 1 nM; Bcl-w, K_i≤ 1 nM.
Classic Bcl-2 Inhibitor

ABT-737 : BH3-mimetic inhibitor, Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.

Related Bcl-2 Products

MI-773 (SAR405838) ^New

MI-773 (SAR405838) is an orally available MDM2 antagonist with K_i of 0.88 nM. Phase 1.
Navitoclax (ABT-263)

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with K_i of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
Venetoclax (ABT-199)

Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with K_i of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.

Features:Re-engineered version of ABT-263 (Navitoclax).
ABT-737

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
Sabutoclax

Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
(R)-(-)-Gossypol acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

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Obatoclax Mesylate (GX15-070)