Obatoclax Mesylate (GX15-070)

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.

Obatoclax Mesylate (GX15-070) Chemical Structure

Obatoclax Mesylate (GX15-070) Chemical Structure

CAS: 803712-79-0

Selleck's Obatoclax Mesylate (GX15-070) has been cited by 108 publications

Purity & Quality Control

Batch: Purity: 99.85%
99.85

Obatoclax Mesylate (GX15-070) Related Products

Signaling Pathway

Choose Selective Bcl-2 Inhibitors

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 Growth Inhibition Assay IC50=0.0000317 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=0.000355 μM SANGER
NALM-6 Growth Inhibition Assay IC50=0.000356 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=0.000469 μM SANGER
BHY Growth Inhibition Assay IC50=0.000601 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.000648 μM SANGER
786-0 Growth Inhibition Assay IC50=0.000776 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.000848 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.00106 μM SANGER
EB2 Growth Inhibition Assay IC50=0.00118 μM SANGER
G-361 Growth Inhibition Assay IC50=0.00124 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.00128 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.0014 μM SANGER
MCF7 Growth Inhibition Assay IC50=0.00159 μM SANGER
LOUCY Growth Inhibition Assay IC50=0.00175 μM SANGER
EW-7 Growth Inhibition Assay IC50=0.00175 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=0.00233 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=0.00264 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.00297 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.00335 μM SANGER
A375 Growth Inhibition Assay IC50=0.0035 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.00399 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.00417 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.0043 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.00435 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.00467 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.00498 μM SANGER
SW620 Growth Inhibition Assay IC50=0.00511 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.00524 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.006 μM SANGER
IGR-1 Growth Inhibition Assay IC50=0.00601 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.00651 μM SANGER
769-P Growth Inhibition Assay IC50=0.00678 μM SANGER
HN Growth Inhibition Assay IC50=0.00679 μM SANGER
SIG-M5 Growth Inhibition Assay IC50=0.0071 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.00818 μM SANGER
ST486 Growth Inhibition Assay IC50=0.00825 μM SANGER
ES7 Growth Inhibition Assay IC50=0.00846 μM SANGER
GAK Growth Inhibition Assay IC50=0.00848 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.00858 μM SANGER
IPC-298 Growth Inhibition Assay IC50=0.00927 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.00972 μM SANGER
RKO Growth Inhibition Assay IC50=0.01044 μM SANGER
ACN Growth Inhibition Assay IC50=0.01131 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.01225 μM SANGER
SR Growth Inhibition Assay IC50=0.01235 μM SANGER
SNG-M Growth Inhibition Assay IC50=0.01317 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.01346 μM SANGER
HSC-3 Growth Inhibition Assay IC50=0.01355 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.01412 μM SANGER
NB69 Growth Inhibition Assay IC50=0.01565 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.01581 μM SANGER
RVH-421 Growth Inhibition Assay IC50=0.01674 μM SANGER
TGW Growth Inhibition Assay IC50=0.01739 μM SANGER
HCC1569 Growth Inhibition Assay IC50=0.01797 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=0.01832 μM SANGER
RPMI-8402 Growth Inhibition Assay IC50=0.01858 μM SANGER
THP-1 Growth Inhibition Assay IC50=0.01998 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.02036 μM SANGER
A2780 Growth Inhibition Assay IC50=0.02079 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=0.02296 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.02348 μM SANGER
MC-CAR Growth Inhibition Assay IC50=0.02356 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.02466 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.02473 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.02602 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.02847 μM SANGER
S-117 Growth Inhibition Assay IC50=0.02906 μM SANGER
SUP-T1 Growth Inhibition Assay IC50=0.02949 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.02959 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.02976 μM SANGER
CMK Growth Inhibition Assay IC50=0.03023 μM SANGER
8505C Growth Inhibition Assay IC50=0.0304 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=0.03048 μM SANGER
A101D Growth Inhibition Assay IC50=0.03055 μM SANGER
G-401 Growth Inhibition Assay IC50=0.03093 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.03107 μM SANGER
IMR-5 Growth Inhibition Assay IC50=0.03244 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.03393 μM SANGER
HOS Growth Inhibition Assay IC50=0.03473 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.0368 μM SANGER
SW756 Growth Inhibition Assay IC50=0.03821 μM SANGER
NCI-H64 Growth Inhibition Assay IC50=0.03842 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.03909 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.04005 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=0.04011 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.04018 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.04118 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.04232 μM SANGER
EW-13 Growth Inhibition Assay IC50=0.04406 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.0449 μM SANGER
SCC-25 Growth Inhibition Assay IC50=0.04494 μM SANGER
REH Growth Inhibition Assay IC50=0.04635 μM SANGER
L-363 Growth Inhibition Assay IC50=0.04679 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=0.04697 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.04857 μM SANGER
ES1 Growth Inhibition Assay IC50=0.04885 μM SANGER
SCC-15 Growth Inhibition Assay IC50=0.04902 μM SANGER
MRK-nu-1 Growth Inhibition Assay IC50=0.04936 μM SANGER
PF-382 Growth Inhibition Assay IC50=0.04939 μM SANGER
COLO-680N Growth Inhibition Assay IC50=0.05047 μM SANGER
LK-2 Growth Inhibition Assay IC50=0.05063 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=0.05117 μM SANGER
HMV-II Growth Inhibition Assay IC50=0.05239 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.05252 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.05289 μM SANGER
697 Growth Inhibition Assay IC50=0.05323 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.0559 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.05594 μM SANGER
Daoy Growth Inhibition Assay IC50=0.05616 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.05672 μM SANGER
A388 Growth Inhibition Assay IC50=0.05695 μM SANGER
COLO-205 Growth Inhibition Assay IC50=0.05716 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.05729 μM SANGER
SF268 Growth Inhibition Assay IC50=0.05756 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.05777 μM SANGER
GAMG Growth Inhibition Assay IC50=0.058 μM SANGER
BCPAP Growth Inhibition Assay IC50=0.05892 μM SANGER
BC-1 Growth Inhibition Assay IC50=0.06022 μM SANGER
IA-LM Growth Inhibition Assay IC50=0.06053 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.0613 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.06134 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.06142 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.06188 μM SANGER
BL-41 Growth Inhibition Assay IC50=0.06219 μM SANGER
BL-70 Growth Inhibition Assay IC50=0.06302 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.06411 μM SANGER
NB13 Growth Inhibition Assay IC50=0.06421 μM SANGER
CAL-27 Growth Inhibition Assay IC50=0.06464 μM SANGER
CA46 Growth Inhibition Assay IC50=0.06537 μM SANGER
SW962 Growth Inhibition Assay IC50=0.06569 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=0.06632 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=0.06945 μM SANGER
Daudi Growth Inhibition Assay IC50=0.07081 μM SANGER
SW626 Growth Inhibition Assay IC50=0.07204 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.07246 μM SANGER
YT Growth Inhibition Assay IC50=0.07345 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=0.07349 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=0.07458 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.07517 μM SANGER
MLMA Growth Inhibition Assay IC50=0.07534 μM SANGER
WSU-NHL Growth Inhibition Assay IC50=0.07554 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.07588 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.07668 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.07801 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=0.07879 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.07909 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.08053 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.08095 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.08245 μM SANGER
CESS Growth Inhibition Assay IC50=0.08269 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.08333 μM SANGER
DEL Growth Inhibition Assay IC50=0.08347 μM SANGER
5637 Growth Inhibition Assay IC50=0.08367 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.08497 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=0.08509 μM SANGER
A427 Growth Inhibition Assay IC50=0.08512 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.08566 μM SANGER
LS-123 Growth Inhibition Assay IC50=0.08719 μM SANGER
LoVo Growth Inhibition Assay IC50=0.0872 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.08769 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=0.08793 μM SANGER
A431 Growth Inhibition Assay IC50=0.08801 μM SANGER
HCT-116 Growth Inhibition Assay IC50=0.08802 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.08947 μM SANGER
RPMI-6666 Growth Inhibition Assay IC50=0.08967 μM SANGER
Calu-6 Growth Inhibition Assay IC50=0.09029 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=0.09039 μM SANGER
A704 Growth Inhibition Assay IC50=0.0915 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=0.09249 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.09378 μM SANGER
U-698-M Growth Inhibition Assay IC50=0.09409 μM SANGER
IST-SL2 Growth Inhibition Assay IC50=0.09468 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.09584 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.09671 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=0.09797 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.09885 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.09897 μM SANGER
NCI-H460 Growth Inhibition Assay IC50=0.1009 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.10255 μM SANGER
ES4 Growth Inhibition Assay IC50=0.10264 μM SANGER
HUTU-80 Growth Inhibition Assay IC50=0.10365 μM SANGER
647-V Growth Inhibition Assay IC50=0.10408 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.10432 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.10448 μM SANGER
A2058 Growth Inhibition Assay IC50=0.10655 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.1083 μM SANGER
J82 Growth Inhibition Assay IC50=0.10884 μM SANGER
ARH-77 Growth Inhibition Assay IC50=0.11 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.11128 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.11286 μM SANGER
MC116 Growth Inhibition Assay IC50=0.11337 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=0.11467 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=0.11491 μM SANGER
SF539 Growth Inhibition Assay IC50=0.11616 μM SANGER
ES8 Growth Inhibition Assay IC50=0.11633 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=0.11664 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.1175 μM SANGER
NY Growth Inhibition Assay IC50=0.11817 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.12148 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.12374 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.12383 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.12531 μM SANGER
HT-1376 Growth Inhibition Assay IC50=0.12668 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.12866 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.12867 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.12913 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.12914 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.12916 μM SANGER
EW-18 Growth Inhibition Assay IC50=0.13026 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=0.13027 μM SANGER
COLO-792 Growth Inhibition Assay IC50=0.13165 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.13223 μM SANGER
ACHN Growth Inhibition Assay IC50=0.13247 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=0.13261 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.13449 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.13628 μM SANGER
MFE-296 Growth Inhibition Assay IC50=0.13864 μM SANGER
RD Growth Inhibition Assay IC50=0.13997 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.14295 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.143 μM SANGER
ES6 Growth Inhibition Assay IC50=0.1436 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.14407 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.14707 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.15293 μM SANGER
HEL Growth Inhibition Assay IC50=0.15447 μM SANGER
639-V Growth Inhibition Assay IC50=0.15596 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.15639 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.15668 μM SANGER
SW872 Growth Inhibition Assay IC50=0.16042 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.16162 μM SANGER
YKG-1 Growth Inhibition Assay IC50=0.16273 μM SANGER
GT3TKB Growth Inhibition Assay IC50=0.16283 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.16424 μM SANGER
KARPAS-422 Growth Inhibition Assay IC50=0.16574 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.16656 μM SANGER
HLE Growth Inhibition Assay IC50=0.16877 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.16986 μM SANGER
EB-3 Growth Inhibition Assay IC50=0.1731 μM SANGER
HCC1143 Growth Inhibition Assay IC50=0.17396 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.17451 μM SANGER
BT-474 Growth Inhibition Assay IC50=0.17489 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.17545 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.17601 μM SANGER
MKN28 Growth Inhibition Assay IC50=0.17653 μM SANGER
TK10 Growth Inhibition Assay IC50=0.17702 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.17949 μM SANGER
8305C Growth Inhibition Assay IC50=0.17971 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.17977 μM SANGER
NCI-H522 Growth Inhibition Assay IC50=0.18094 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=0.18292 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.18527 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=0.18629 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=0.19148 μM SANGER
AM-38 Growth Inhibition Assay IC50=0.19225 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.19305 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=0.19637 μM SANGER
OAW-28 Growth Inhibition Assay IC50=0.20178 μM SANGER
TE-15 Growth Inhibition Assay IC50=0.20252 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.20284 μM SANGER
JiyoyeP-2003 Growth Inhibition Assay IC50=0.20336 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.20628 μM SANGER
SNU-449 Growth Inhibition Assay IC50=0.20797 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.21215 μM SANGER
T84 Growth Inhibition Assay IC50=0.21248 μM SANGER
LP-1 Growth Inhibition Assay IC50=0.21302 μM SANGER
MG-63 Growth Inhibition Assay IC50=0.21382 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.21478 μM SANGER
L-540 Growth Inhibition Assay IC50=0.21598 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.22242 μM SANGER
HCT-15 Growth Inhibition Assay IC50=0.22484 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.22488 μM SANGER
GP5d Growth Inhibition Assay IC50=0.22528 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=0.22734 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.22889 μM SANGER
CAL-39 Growth Inhibition Assay IC50=0.22936 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.23287 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.2332 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.23372 μM SANGER
DB Growth Inhibition Assay IC50=0.23438 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=0.23571 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.23946 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.2405 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.24169 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.24571 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.24692 μM SANGER
OE33 Growth Inhibition Assay IC50=0.2511 μM SANGER
Calu-3 Growth Inhibition Assay IC50=0.25297 μM SANGER
HT Growth Inhibition Assay IC50=0.25621 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.25984 μM SANGER
KGN Growth Inhibition Assay IC50=0.26089 μM SANGER
NCI-H1417 Growth Inhibition Assay IC50=0.26524 μM SANGER
SF126 Growth Inhibition Assay IC50=0.27302 μM SANGER
SAS Growth Inhibition Assay IC50=0.27308 μM SANGER
22RV1 Growth Inhibition Assay IC50=0.27378 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.27487 μM SANGER
ES3 Growth Inhibition Assay IC50=0.27763 μM SANGER
NB1 Growth Inhibition Assay IC50=0.27876 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=0.28302 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.28554 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.2914 μM SANGER
CAL-120 Growth Inhibition Assay IC50=0.29631 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.30241 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.30249 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.3036 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.30526 μM SANGER
GCIY Growth Inhibition Assay IC50=0.31002 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.31106 μM SANGER
U-266 Growth Inhibition Assay IC50=0.31147 μM SANGER
Calu-1 Growth Inhibition Assay IC50=0.31289 μM SANGER
SK-LMS-1 Growth Inhibition Assay IC50=0.31429 μM SANGER
COLO-741 Growth Inhibition Assay IC50=0.31614 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.31641 μM SANGER
KM12 Growth Inhibition Assay IC50=0.3183 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.3186 μM SANGER
SJRH30 Growth Inhibition Assay IC50=0.32052 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.32218 μM SANGER
IM-9 Growth Inhibition Assay IC50=0.33021 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.33317 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.33432 μM SANGER
U251 Growth Inhibition Assay IC50=0.33456 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.33951 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.33984 μM SANGER
SF295 Growth Inhibition Assay IC50=0.33999 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.345 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=0.34732 μM SANGER
NCI-H2009 Growth Inhibition Assay IC50=0.34739 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.35815 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.36667 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.3683 μM SANGER
L-428 Growth Inhibition Assay IC50=0.37016 μM SANGER
C3A Growth Inhibition Assay IC50=0.37379 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.37655 μM SANGER
HuH-7 Growth Inhibition Assay IC50=0.3791 μM SANGER
AGS Growth Inhibition Assay IC50=0.38638 μM SANGER
HT-1197 Growth Inhibition Assay IC50=0.3946 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.39913 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.40045 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=0.40055 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.40303 μM SANGER
SW954 Growth Inhibition Assay IC50=0.40335 μM SANGER
MES-SA Growth Inhibition Assay IC50=0.40505 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.40524 μM SANGER
SW13 Growth Inhibition Assay IC50=0.40626 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=0.40805 μM SANGER
U-118-MG Growth Inhibition Assay IC50=0.40904 μM SANGER
NCI-H1734 Growth Inhibition Assay IC50=0.42013 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.42033 μM SANGER
AU565 Growth Inhibition Assay IC50=0.42468 μM SANGER
FADU Growth Inhibition Assay IC50=0.42649 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.43083 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=0.43626 μM SANGER
MONO-MAC-6 Growth Inhibition Assay IC50=0.43849 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.44371 μM SANGER
SW982 Growth Inhibition Assay IC50=0.44528 μM SANGER
SCC-3 Growth Inhibition Assay IC50=0.44579 μM SANGER
C32 Growth Inhibition Assay IC50=0.45229 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.45299 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.45373 μM SANGER
M14 Growth Inhibition Assay IC50=0.45979 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.46256 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.46384 μM SANGER
SW837 Growth Inhibition Assay IC50=0.46722 μM SANGER
DU-145 Growth Inhibition Assay IC50=0.46729 μM SANGER
LB996-RCC Growth Inhibition Assay IC50=0.47054 μM SANGER
C8166 Growth Inhibition Assay IC50=0.474 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.47734 μM SANGER
DMS-53 Growth Inhibition Assay IC50=0.47809 μM SANGER
TE-5 Growth Inhibition Assay IC50=0.48305 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.48343 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.4886 μM SANGER
SIMA Growth Inhibition Assay IC50=0.49417 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=0.4967 μM SANGER
HCC1599 Growth Inhibition Assay IC50=0.49955 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.50496 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.50844 μM SANGER
OPM-2 Growth Inhibition Assay IC50=0.50937 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.50957 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.51119 μM SANGER
LC4-1 Growth Inhibition Assay IC50=0.51403 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.5157 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=0.52288 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=0.52434 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.52827 μM SANGER
NCI-H838 Growth Inhibition Assay IC50=0.52849 μM SANGER
K5 Growth Inhibition Assay IC50=0.53201 μM SANGER
CAL-72 Growth Inhibition Assay IC50=0.53387 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.53959 μM SANGER
SNB75 Growth Inhibition Assay IC50=0.5573 μM SANGER
BPH-1 Growth Inhibition Assay IC50=0.56344 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.56372 μM SANGER
G-402 Growth Inhibition Assay IC50=0.56499 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=0.56741 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.57166 μM SANGER
COR-L279 Growth Inhibition Assay IC50=0.57185 μM SANGER
A253 Growth Inhibition Assay IC50=0.57525 μM SANGER
SK-MM-2 Growth Inhibition Assay IC50=0.57679 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.59427 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.59487 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.60011 μM SANGER
ES5 Growth Inhibition Assay IC50=0.6048 μM SANGER
MHH-CALL-2 Growth Inhibition Assay IC50=0.60888 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.61229 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.6198 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=0.64586 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.65611 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.65819 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.66587 μM SANGER
Capan-2 Growth Inhibition Assay IC50=0.66622 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.66698 μM SANGER
COLO-824 Growth Inhibition Assay IC50=0.67823 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=0.68258 μM SANGER
GDM-1 Growth Inhibition Assay IC50=0.68494 μM SANGER
KP-4 Growth Inhibition Assay IC50=0.69573 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.69986 μM SANGER
KM-H2 Growth Inhibition Assay IC50=0.70091 μM SANGER
HH Growth Inhibition Assay IC50=0.70662 μM SANGER
DK-MG Growth Inhibition Assay IC50=0.71016 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.71259 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.71985 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.72104 μM SANGER
NB12 Growth Inhibition Assay IC50=0.72504 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.74083 μM SANGER
A673 Growth Inhibition Assay IC50=0.75177 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.76087 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.77052 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.77186 μM SANGER
SW48 Growth Inhibition Assay IC50=0.77333 μM SANGER
NCI-H2081 Growth Inhibition Assay IC50=0.78147 μM SANGER
RMG-I Growth Inhibition Assay IC50=0.78212 μM SANGER
LU-99A Growth Inhibition Assay IC50=0.78413 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.78921 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=0.80131 μM SANGER
U031 Growth Inhibition Assay IC50=0.81423 μM SANGER
EVSA-T Growth Inhibition Assay IC50=0.81672 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=0.82271 μM SANGER
EHEB Growth Inhibition Assay IC50=0.82276 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.82555 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.82843 μM SANGER
EFO-21 Growth Inhibition Assay IC50=0.84089 μM SANGER
DOK Growth Inhibition Assay IC50=0.848 μM SANGER
NCI-H2171 Growth Inhibition Assay IC50=0.8496 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.8557 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.85943 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.86801 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.8711 μM SANGER
SN12C Growth Inhibition Assay IC50=0.88637 μM SANGER
A172 Growth Inhibition Assay IC50=0.88698 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=0.88753 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=0.89339 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.90264 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=0.91344 μM SANGER
MDA-MB-468 Growth Inhibition Assay IC50=0.9173 μM SANGER
NCI-H1694 Growth Inhibition Assay IC50=0.91876 μM SANGER
CCF-STTG1 Growth Inhibition Assay IC50=0.92637 μM SANGER
K052 Growth Inhibition Assay IC50=0.94047 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.9501 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.96291 μM SANGER
KU812 Growth Inhibition Assay IC50=0.99389 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.99777 μM SANGER
Raji Growth Inhibition Assay IC50=1.02267 μM SANGER
TE-6 Growth Inhibition Assay IC50=1.03566 μM SANGER
CAL-148 Growth Inhibition Assay IC50=1.04443 μM SANGER
NCI-H1963 Growth Inhibition Assay IC50=1.04553 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=1.04685 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=1.06349 μM SANGER
BEN Growth Inhibition Assay IC50=1.07137 μM SANGER
CAS-1 Growth Inhibition Assay IC50=1.09123 μM SANGER
SW780 Growth Inhibition Assay IC50=1.09181 μM SANGER
LU-65 Growth Inhibition Assay IC50=1.0941 μM SANGER
D-283MED Growth Inhibition Assay IC50=1.12272 μM SANGER
HCC2157 Growth Inhibition Assay IC50=1.13642 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=1.14006 μM SANGER
PLC-PRF-5 Growth Inhibition Assay IC50=1.15229 μM SANGER
H4 Growth Inhibition Assay IC50=1.15439 μM SANGER
TUR Growth Inhibition Assay IC50=1.15752 μM SANGER
NCI-H2141 Growth Inhibition Assay IC50=1.18946 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=1.20532 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=1.23221 μM SANGER
SCC-9 Growth Inhibition Assay IC50=1.23665 μM SANGER
T47D Growth Inhibition Assay IC50=1.23696 μM SANGER
TCCSUP Growth Inhibition Assay IC50=1.25029 μM SANGER
SU-DHL-1 Growth Inhibition Assay IC50=1.25118 μM SANGER
HL-60 Growth Inhibition Assay IC50=1.25588 μM SANGER
NCI-H1436 Growth Inhibition Assay IC50=1.26149 μM SANGER
DMS-114 Growth Inhibition Assay IC50=1.26632 μM SANGER
BOKU Growth Inhibition Assay IC50=1.28095 μM SANGER
MS-1 Growth Inhibition Assay IC50=1.29069 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=1.30478 μM SANGER
HT-3 Growth Inhibition Assay IC50=1.30529 μM SANGER
CAL-54 Growth Inhibition Assay IC50=1.30725 μM SANGER
SW1463 Growth Inhibition Assay IC50=1.31872 μM SANGER
COLO-668 Growth Inhibition Assay IC50=1.33056 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=1.33803 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=1.3401 μM SANGER
M059J Growth Inhibition Assay IC50=1.35832 μM SANGER
NCCIT Growth Inhibition Assay IC50=1.37988 μM SANGER
LN-405 Growth Inhibition Assay IC50=1.39264 μM SANGER
UMC-11 Growth Inhibition Assay IC50=1.39996 μM SANGER
NB5 Growth Inhibition Assay IC50=1.41227 μM SANGER
TE-441-T Growth Inhibition Assay IC50=1.42817 μM SANGER
ME-180 Growth Inhibition Assay IC50=1.44392 μM SANGER
HCC70 Growth Inhibition Assay IC50=1.46096 μM SANGER
no-10 Growth Inhibition Assay IC50=1.46181 μM SANGER
JEG-3 Growth Inhibition Assay IC50=1.50132 μM SANGER
no-11 Growth Inhibition Assay IC50=1.50882 μM SANGER
CHP-126 Growth Inhibition Assay IC50=1.56691 μM SANGER
EGI-1 Growth Inhibition Assay IC50=1.58025 μM SANGER
D-392MG Growth Inhibition Assay IC50=1.5963 μM SANGER
RT4 Growth Inhibition Assay IC50=1.59637 μM SANGER
A204 Growth Inhibition Assay IC50=1.59801 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=1.63591 μM SANGER
Becker Growth Inhibition Assay IC50=1.64241 μM SANGER
OE19 Growth Inhibition Assay IC50=1.65518 μM SANGER
EKVX Growth Inhibition Assay IC50=1.65618 μM SANGER
KLE Growth Inhibition Assay IC50=1.65714 μM SANGER
K-562 Growth Inhibition Assay IC50=1.67037 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=1.68997 μM SANGER
NCI-H716 Growth Inhibition Assay IC50=1.69304 μM SANGER
Caov-3 Growth Inhibition Assay IC50=1.69413 μM SANGER
HCC1187 Growth Inhibition Assay IC50=1.70545 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=1.72292 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=1.73307 μM SANGER
PC-3 Growth Inhibition Assay IC50=1.7508 μM SANGER
DV-90 Growth Inhibition Assay IC50=1.75585 μM SANGER
RXF393 Growth Inhibition Assay IC50=1.77294 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=1.82339 μM SANGER
HCC1419 Growth Inhibition Assay IC50=1.82692 μM SANGER
BV-173 Growth Inhibition Assay IC50=1.82995 μM SANGER
MKN7 Growth Inhibition Assay IC50=1.8922 μM SANGER
LAN-6 Growth Inhibition Assay IC50=1.89553 μM SANGER
Mo-T Growth Inhibition Assay IC50=1.90039 μM SANGER
HCC1395 Growth Inhibition Assay IC50=1.92863 μM SANGER
HC-1 Growth Inhibition Assay IC50=1.9347 μM SANGER
HPAF-II Growth Inhibition Assay IC50=1.94418 μM SANGER
CPC-N Growth Inhibition Assay IC50=1.98002 μM SANGER
MKN45 Growth Inhibition Assay IC50=1.99119 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=2.00433 μM SANGER
SHP-77 Growth Inhibition Assay IC50=2.00533 μM SANGER
NCI-H1522 Growth Inhibition Assay IC50=2.01724 μM SANGER
SW1573 Growth Inhibition Assay IC50=2.022 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=2.06087 μM SANGER
SCC-4 Growth Inhibition Assay IC50=2.1431 μM SANGER
DMS-153 Growth Inhibition Assay IC50=2.16668 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=2.1752 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=2.22888 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=2.2332 μM SANGER
U-87-MG Growth Inhibition Assay IC50=2.28592 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=2.30102 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=2.32105 μM SANGER
BC-3 Growth Inhibition Assay IC50=2.36509 μM SANGER
HCC38 Growth Inhibition Assay IC50=2.38447 μM SANGER
HCC2218 Growth Inhibition Assay IC50=2.40809 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=2.4125 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=2.41578 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=2.57368 μM SANGER
GMS-10 Growth Inhibition Assay IC50=2.57611 μM SANGER
GCT Growth Inhibition Assay IC50=2.58694 μM SANGER
SK-CO-1 Growth Inhibition Assay IC50=2.6166 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=2.6345 μM SANGER
SW1088 Growth Inhibition Assay IC50=2.77839 μM SANGER
HT55 Growth Inhibition Assay IC50=2.78695 μM SANGER
NB10 Growth Inhibition Assay IC50=2.81748 μM SANGER
UACC-893 Growth Inhibition Assay IC50=2.85749 μM SANGER
NCI-H1618 Growth Inhibition Assay IC50=2.88153 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=3.07812 μM SANGER
SBC-1 Growth Inhibition Assay IC50=3.08553 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=3.0934 μM SANGER
SiHa Growth Inhibition Assay IC50=3.11977 μM SANGER
D-263MG Growth Inhibition Assay IC50=3.14788 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=3.19641 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=3.34439 μM SANGER
NCI-H2196 Growth Inhibition Assay IC50=3.35008 μM SANGER
MFM-223 Growth Inhibition Assay IC50=3.37351 μM SANGER
COLO-678 Growth Inhibition Assay IC50=3.38186 μM SANGER
EW-3 Growth Inhibition Assay IC50=3.4095 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=3.44069 μM SANGER
EM-2 Growth Inhibition Assay IC50=3.6398 μM SANGER
FTC-133 Growth Inhibition Assay IC50=3.65458 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=3.67653 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=3.68355 μM SANGER
LC-1F Growth Inhibition Assay IC50=3.71764 μM SANGER
C-4-II Growth Inhibition Assay IC50=3.75643 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=3.78455 μM SANGER
JVM-2 Growth Inhibition Assay IC50=3.93639 μM SANGER
CaR-1 Growth Inhibition Assay IC50=3.97617 μM SANGER
MDA-MB-134-VI Growth Inhibition Assay IC50=4.02952 μM SANGER
NCI-H719 Growth Inhibition Assay IC50=4.15388 μM SANGER
GOTO Growth Inhibition Assay IC50=4.29705 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=4.38821 μM SANGER
NB6 Growth Inhibition Assay IC50=4.42509 μM SANGER
DSH1 Growth Inhibition Assay IC50=4.47116 μM SANGER
BT-20 Growth Inhibition Assay IC50=4.49002 μM SANGER
NCI-H1882 Growth Inhibition Assay IC50=4.5057 μM SANGER
WM-115 Growth Inhibition Assay IC50=4.50881 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=4.6777 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=4.70275 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=4.83565 μM SANGER
Mewo Growth Inhibition Assay IC50=4.96313 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=5.00509 μM SANGER
T98G Growth Inhibition Assay IC50=5.06508 μM SANGER
ECC4 Growth Inhibition Assay IC50=5.09372 μM SANGER
EW-11 Growth Inhibition Assay IC50=5.18099 μM SANGER
COLO-800 Growth Inhibition Assay IC50=5.19349 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=5.23027 μM SANGER
KMS-12-PE Growth Inhibition Assay IC50=5.35085 μM SANGER
HCC1954 Growth Inhibition Assay IC50=5.85971 μM SANGER
NCI-H187 Growth Inhibition Assay IC50=5.92989 μM SANGER
LU-165 Growth Inhibition Assay IC50=5.99002 μM SANGER
YAPC Growth Inhibition Assay IC50=5.99068 μM SANGER
LU-139 Growth Inhibition Assay IC50=6.08368 μM SANGER
D-502MG Growth Inhibition Assay IC50=6.32047 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=6.53948 μM SANGER
DG-75 Growth Inhibition Assay IC50=6.88786 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=6.95581 μM SANGER
EFE-184 Growth Inhibition Assay IC50=7.31695 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=7.48807 μM SANGER
SW948 Growth Inhibition Assay IC50=7.58395 μM SANGER
NCI-H524 Growth Inhibition Assay IC50=9.58628 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=9.62834 μM SANGER
T-24 Growth Inhibition Assay IC50=9.94415 μM SANGER
NCI-H748 Growth Inhibition Assay IC50=10.6397 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=10.6442 μM SANGER
UACC-812 Growth Inhibition Assay IC50=11.717 μM SANGER
SCLC-21H Growth Inhibition Assay IC50=12.1551 μM SANGER
NCI-SNU-16 Growth Inhibition Assay IC50=13.1258 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=14.6363 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=14.8912 μM SANGER
LB647-SCLC Growth Inhibition Assay IC50=15.7195 μM SANGER
NCI-H345 Growth Inhibition Assay IC50=17.343 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=18.7601 μM SANGER
RL Growth Inhibition Assay IC50=21.2656 μM SANGER
KY821 Growth Inhibition Assay IC50=22.0553 μM SANGER
JVM-3 Growth Inhibition Assay IC50=25.0413 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=28.5499 μM SANGER
LU-134-A Growth Inhibition Assay IC50=30.2037 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=32.2431 μM SANGER
NCI-H1993 Growth Inhibition Assay IC50=32.8218 μM SANGER
P31-FUJ Growth Inhibition Assay IC50=33.4899 μM SANGER
LS-513 Growth Inhibition Assay IC50=35.8879 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=40.3499 μM SANGER
SW684 Growth Inhibition Assay IC50=43.9661 μM SANGER
COR-L88 Growth Inhibition Assay IC50=44.0665 μM SANGER
NCI-H889 Growth Inhibition Assay IC50=45.0087 μM SANGER
TALL-1 Growth Inhibition Assay IC50=46.1199 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=47.1993 μM SANGER
Click to View More Cell Line Experimental Data

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Kinase Assay Bcl-2 Binding affinity calculation
A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research Cell lines Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
Concentrations ~10 μM
Incubation Time 48-72 hours
Method

Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.

Experimental Result Images Methods Biomarkers Images PMID
Western blot Cyclin D1 / p27 Kip1 p-Cyclin D1 p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38 28382170
Growth inhibition assay Cell proliferation Cell viability 28035994
In Vivo
In vivo

Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Animal Research Animal Models Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
Dosages 0.0313, 0.25, 0.5 and 2 mg/kg
Administration Administered intravenously (tail vein) once a day
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed
Hematological Malignancies
Gemin X|Teva Branded Pharmaceutical Products R&D Inc.
October 2005 Phase 1
NCT00600964 Completed
Chronic Lymphocytic Leukemia
Gemin X|Teva Branded Pharmaceutical Products R&D Inc.
September 2004 Phase 1

Chemical Information & Solubility

Molecular Weight 413.49 Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0 SDF Download Obatoclax Mesylate (GX15-070) SDF
Smiles CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (200.73 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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