Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Cited by 28 Publications

9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell Death Dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;TUmlEPTB;MD6wNFAxOzF5IN88US=> NYnPNmw2W0GQR1XS
SK-MEL-30 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwMECwN|U2KM7:TR?= NX3kOYxIW0GQR1XS
NALM-6 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7HSGF{UUN3ME2wMlAxODN3NjFOwG0> MW\TRW5ITVJ?
KYSE-450 M4HE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vvNmlEPTB;MD6wNFA1PjlizszN MkjjV2FPT0WU
BHY M3;tRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[4cGlEPTB;MD6wNFA3ODFizszN MmDMV2FPT0WU
GR-ST NIDFZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMECwOlQ5KM7:TR?= M2rVNXNCVkeHUh?=
786-0 M13s[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfkfphUUUN3ME2wMlAxODd5NjFOwG0> M3jG[XNCVkeHUh?=
C-33-A MlzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMECwPFQ5KM7:TR?= NH\UfGRUSU6JRWK=
BHT-101 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLXT2pKSzVyPUCuNFAyODZizszN NH7LflJUSU6JRWK=
EB2 M3TPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnVeWFKSzVyPUCuNFAyOThizszN MlvQV2FPT0WU
G-361 NVv4S41sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHtVG5KSzVyPUCuNFAyOjRizszN NWXQOHp3W0GQR1XS
KE-37 M3nKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1v0[GlEPTB;MD6wNFEzQCEQvF2= MX;TRW5ITVJ?
MHH-PREB-1 NXzMVHlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn6N3JKSzVyPUCuNFAyPCEQvF2= NHzDWotUSU6JRWK=
MCF7 MnvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\kV2lEPTB;MD6wNFE2QSEQvF2= MUDTRW5ITVJ?
LOUCY NXnHRoQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjROmdKSzVyPUCuNFAyPzVizszN MoXxV2FPT0WU
EW-7 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;wUnl1UUN3ME2wMlAxOTd3IN88US=> MYHTRW5ITVJ?
KYSE-510 NIHHeGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\jV2o2UUN3ME2wMlAxOjN|IN88US=> M3XL[nNCVkeHUh?=
SK-MEL-3 NIHBWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTiTWM2OD1yLkCwNlY1KM7:TR?= NXjKd5ZIW0GQR1XS
HAL-01 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLKeJhKSzVyPUCuNFAzQTdizszN M2fOdnNCVkeHUh?=
HCC2998 NYPET2l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMECzN|Uh|ryP MVTTRW5ITVJ?
A375 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XHO2lEPTB;MD6wNFM2KM7:TR?= MkHBV2FPT0WU
MZ7-mel MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DqfWlEPTB;MD6wNFM6QSEQvF2= MWLTRW5ITVJ?
SH-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO0TWM2OD1yLkCwOFE4KM7:TR?= NUX4bmRuW0GQR1XS
HT-144 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMEC0N{DPxE1? NHjWe2tUSU6JRWK=
KYSE-140 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL2TWM2OD1yLkCwOFM2KM7:TR?= NILGe2dUSU6JRWK=
PSN1 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITFUIxKSzVyPUCuNFA1PjdizszN MkjPV2FPT0WU
COLO-679 NEPJO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojVTWM2OD1yLkCwOFk5KM7:TR?= M3L5UXNCVkeHUh?=
SW620 NWq3WWJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEC1NVEh|ryP M3\kXnNCVkeHUh?=
HGC-27 M{XUcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPXTWM2OD1yLkCwOVI1KM7:TR?= M2[1dnNCVkeHUh?=
IGROV-1 NGK4W41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWriZVR1UUN3ME2wMlAxPiEQvF2= MWfTRW5ITVJ?
IGR-1 NGfLV2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TXc2lEPTB;MD6wNFYxOSEQvF2= MYjTRW5ITVJ?
EW-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXSTWM2OD1yLkCwOlUyKM7:TR?= M{jRfHNCVkeHUh?=
769-P MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLtZZJqUUN3ME2wMlAxPjd6IN88US=> NWC3OmJmW0GQR1XS
HN M2j0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXywRotHUUN3ME2wMlAxPjd7IN88US=> NXvUNnlGW0GQR1XS
SIG-M5 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fjPGlEPTB;MD6wNFcyKM7:TR?= M1K3ZXNCVkeHUh?=
IST-MEL1 M3;URWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4izN2lEPTB;MD6wNFgyQCEQvF2= MkXnV2FPT0WU
ST486 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDkTWM2OD1yLkCwPFI2KM7:TR?= MWnTRW5ITVJ?
ES7 M{X3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWryfWVQUUN3ME2wMlAxQDR4IN88US=> MlniV2FPT0WU
GAK NHG4blZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzIV2k4UUN3ME2wMlAxQDR6IN88US=> NGrOWGxUSU6JRWK=
BB30-HNC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEC4OVgh|ryP M1fa[3NCVkeHUh?=
IPC-298 NX7aZWkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvxe5BoUUN3ME2wMlAxQTJ5IN88US=> Mo\6V2FPT0WU
NKM-1 MoruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMEC5O|Ih|ryP M1LET3NCVkeHUh?=
RKO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn1TWM2OD1yLkCxNFQ1KM7:TR?= NFvIRYFUSU6JRWK=
ACN NXPLZ49uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXsTWM2OD1yLkCxNVMyKM7:TR?= M4nBXHNCVkeHUh?=
SW1417 MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH:2eItKSzVyPUCuNFEzOjVizszN M3OzNnNCVkeHUh?=
SR MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3sR5lKSzVyPUCuNFEzOzVizszN M{fzcnNCVkeHUh?=
SNG-M MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjNTWM2OD1yLkCxN|E4KM7:TR?= MWLTRW5ITVJ?
CAL-12T NXfFb4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrTfmhKSzVyPUCuNFE{PDZizszN MYrTRW5ITVJ?
HSC-3 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37pe2lEPTB;MD6wNVM2PSEQvF2= NIi3T3JUSU6JRWK=
DOHH-2 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\MTWM2OD1yLkCxOFEzKM7:TR?= MoTNV2FPT0WU
NB69 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHPW2JKSzVyPUCuNFE2PjVizszN NVzhSFVVW0GQR1XS
LC-2-ad M{TlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPmTWM2OD1yLkCxOVgyKM7:TR?= MWnTRW5ITVJ?
RVH-421 NIPPXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETCW|ZKSzVyPUCuNFE3PzRizszN Mk\PV2FPT0WU
TGW MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDBTWM2OD1yLkCxO|M6KM7:TR?= MXPTRW5ITVJ?
HCC1569 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HnemlEPTB;MD6wNVc6PyEQvF2= NGHPNndUSU6JRWK=
CAL-85-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M170bmlEPTB;MD6wNVg{OiEQvF2= MULTRW5ITVJ?
RPMI-8402 NX;ad2hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;jTWM2OD1yLkCxPFU5KM7:TR?= MUTTRW5ITVJ?
THP-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEG5PVgh|ryP NV23ZWh1W0GQR1XS
ONS-76 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHjPGtCUUN3ME2wMlAzODN4IN88US=> MX3TRW5ITVJ?
A2780 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX72UFBUUUN3ME2wMlAzODd7IN88US=> NUfDVJZwW0GQR1XS
RPMI-2650 NH;tbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEKyPVYh|ryP MV;TRW5ITVJ?
MEL-HO M4TrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMEKzOFgh|ryP M2DzPHNCVkeHUh?=
MC-CAR M4LP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jueGlEPTB;MD6wNlM2PiEQvF2= M{KzbHNCVkeHUh?=
HSC-2 M1z6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\KTWM2OD1yLkCyOFY3KM7:TR?= MVLTRW5ITVJ?
MEL-JUSO NGrhNXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPXTWM2OD1yLkCyOFc{KM7:TR?= MWHTRW5ITVJ?
CAL-62 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfuTWM2OD1yLkCyOlAzKM7:TR?= NHHoTVJUSU6JRWK=
DMS-273 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DMSGlEPTB;MD6wNlg1PyEQvF2= MVTTRW5ITVJ?
S-117 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjEXXV5UUN3ME2wMlAzQTB4IN88US=> MoLEV2FPT0WU
SUP-T1 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHQVVJKSzVyPUCuNFI6PDlizszN NG\McmxUSU6JRWK=
MZ2-MEL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDjXmFrUUN3ME2wMlAzQTV7IN88US=> NInkd4VUSU6JRWK=
KYSE-270 M1vnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfoTWM2OD1yLkCyPVc3KM7:TR?= NUe4PJU3W0GQR1XS
CMK M1jqZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEOwNlMh|ryP NFfnVVdUSU6JRWK=
8505C MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW1d45WUUN3ME2wMlA{ODRizszN Mn;QV2FPT0WU
NUGC-3 Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX1[ZVKSzVyPUCuNFMxPDhizszN NIDyUVhUSU6JRWK=
A101D NIKwOoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvjTWM2OD1yLkCzNFU2KM7:TR?= MWTTRW5ITVJ?
G-401 M2fNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwMEOwPVMh|ryP NUPVXnB4W0GQR1XS
OVCAR-8 M{LpNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TwbmlEPTB;MD6wN|ExPyEQvF2= MlfIV2FPT0WU
IMR-5 NGS5NohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DvVWlEPTB;MD6wN|I1PCEQvF2= NGftNW1USU6JRWK=
DoTc2-4510 M1rPW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTB[VRHUUN3ME2wMlA{Ozl|IN88US=> MXjTRW5ITVJ?
HOS M33ZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEO0O|Mh|ryP NHHMcVNUSU6JRWK=
HEC-1 NVXoXlJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:zd4VKSzVyPUCuNFM3QCEQvF2= M4jSbnNCVkeHUh?=
SW756 NF\P[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEO4NlEh|ryP NV\vfmVqW0GQR1XS
NCI-H64 NF\4Z4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEO4OFIh|ryP MnPBV2FPT0WU
EW-16 MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\VTWM2OD1yLkCzPVA6KM7:TR?= NHzWWY9USU6JRWK=
CAL-51 NGTwZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMESwNFUh|ryP NFPFNmJUSU6JRWK=
KYSE-150 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vJU2lEPTB;MD6wOFAyOSEQvF2= MV3TRW5ITVJ?
SW1710 MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz1cVdKSzVyPUCuNFQxOThizszN MUfTRW5ITVJ?
HuP-T4 NF76W|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\MSGhKUUN3ME2wMlA1OTF6IN88US=> M2frfnNCVkeHUh?=
LB373-MEL-D MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOzOJkxUUN3ME2wMlA1OjN{IN88US=> M2fsTXNCVkeHUh?=
EW-13 M{XvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rjWWlEPTB;MD6wOFQxPiEQvF2= MXLTRW5ITVJ?
HT-29 MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfITWM2OD1yLkC0OFkh|ryP MXrTRW5ITVJ?
SCC-25 NUK1cm5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vS[mlEPTB;MD6wOFQ6PCEQvF2= NHXiZpFUSU6JRWK=
REH M2LZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7pWVJ{UUN3ME2wMlA1PjN3IN88US=> M1TFUnNCVkeHUh?=
L-363 NX;FW|ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMES2O|kh|ryP MlnaV2FPT0WU
NCI-H1770 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHwTWM2OD1yLkC0Olk4KM7:TR?= MXvTRW5ITVJ?
CHL-1 MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjUO5A4UUN3ME2wMlA1QDV5IN88US=> NXHXXZBbW0GQR1XS
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Ca-Ski NX\ZWXBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK5eGVWUUN3ME2wMlQxPTJ2IN88US=> M3zEe3NCVkeHUh?=
SW13 NV;LUpVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy5O|h7UUN3ME2wMlQxPjJ4IN88US=> NFH6[WtUSU6JRWK=
NCI-H1437 NVrMfnF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XlW2lEPTB;MD60NFgxPSEQvF2= MXPTRW5ITVJ?
U-118-MG NVXOPYVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1juR2lEPTB;MD60NFkxPCEQvF2= NGXWTmdUSU6JRWK=
NCI-H1734 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwNEKwNVMh|ryP NX7MTnVDW0GQR1XS
HDLM-2 NX\TdG5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jER2lEPTB;MD60NlA{OyEQvF2= MWLTRW5ITVJ?
AU565 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTVTWM2OD1yLkSyOFY5KM7:TR?= MXfTRW5ITVJ?
FADU MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4qyfmlEPTB;MD60NlY1QSEQvF2= MYjTRW5ITVJ?
OS-RC-2 NYfKeYhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq5SGpKSzVyPUCuOFMxQDNizszN NIfoeWlUSU6JRWK=
CAMA-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX5RXdGUUN3ME2wMlQ{PjJ4IN88US=> M33lNnNCVkeHUh?=
MONO-MAC-6 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwNEO4OFkh|ryP MWDTRW5ITVJ?
LB831-BLC NF73cFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELwO4tKSzVyPUCuOFQ{PzFizszN NF;UUW5USU6JRWK=
SW982 NHLKb3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnXSmpKSzVyPUCuOFQ2OjhizszN NVnSepk3W0GQR1XS
SCC-3 NFfRTpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zHS2lEPTB;MD60OFU4QSEQvF2= NIXFNY9USU6JRWK=
C32 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNEWyNlkh|ryP NHHxSXlUSU6JRWK=
BFTC-909 M3vIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rRZmlEPTB;MD60OVI6QSEQvF2= NX\YXm1YW0GQR1XS
MEG-01 NH7uW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHlcG9KSzVyPUCuOFU{PzNizszN M4rpT3NCVkeHUh?=
M14 NHGyUndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPrTWM2OD1yLkS1PVc6KM7:TR?= NXvsSJU1W0GQR1XS
MPP-89 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD1yLkS2NlU3KM7:TR?= MYfTRW5ITVJ?
HCC1937 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvhTWM2OD1yLkS2N|g1KM7:TR?= NGTvXZlUSU6JRWK=
SW837 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjpNHVKSzVyPUCuOFY4OjJizszN M4\QU3NCVkeHUh?=
DU-145 M4LGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwNE[3Nlkh|ryP M{H1[3NCVkeHUh?=
LB996-RCC MnjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4O3WmlEPTB;MD60O|A2PCEQvF2= M4P0ZXNCVkeHUh?=
C8166 M{PsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLMbpVyUUN3ME2wMlQ4PCEQvF2= MXrTRW5ITVJ?
MOLT-4 NWrG[nd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPZTWM2OD1yLkS3O|M1KM7:TR?= NV\D[Wt1W0GQR1XS
DMS-53 NVzPeZlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX3TWM2OD1yLkS3PFA6KM7:TR?= M1TR[HNCVkeHUh?=
TE-5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjKPGE4UUN3ME2wMlQ5OzB3IN88US=> NFWxOndUSU6JRWK=
KYSE-520 M2HhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;TTWM2OD1yLkS4N|Q{KM7:TR?= NFLkRpVUSU6JRWK=
Detroit562 NX\mfYlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzWbW9KSzVyPUCuOFg5PiEQvF2= NF7NWXJUSU6JRWK=
SIMA M4LEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rScWlEPTB;MD60PVQyPyEQvF2= MkjmV2FPT0WU
NCI-H1651 NX\lfXQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnC[4NKSzVyPUCuOFk3PyEQvF2= MnPwV2FPT0WU
HCC1599 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwNEm5OVUh|ryP NGDaenVUSU6JRWK=
ABC-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\oV4ZSUUN3ME2wMlUxPDl4IN88US=> NHjaUndUSU6JRWK=
CAL-33 NGXJR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwNUC4OFQh|ryP NGLQcpJUSU6JRWK=
OPM-2 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNUC5N|ch|ryP MkDxV2FPT0WU
RPMI-7951 M1\Vd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7wcpNXUUN3ME2wMlUxQTV5IN88US=> MUHTRW5ITVJ?
HT-1080 NEO0dpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHCTWM2OD1yLkWxNVE6KM7:TR?= NHyzUWJUSU6JRWK=
LC4-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNUG0NFMh|ryP NGDYPJZUSU6JRWK=
OVCAR-3 NWC0[|BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwNUG1O{DPxE1? NXPnWWJ4W0GQR1XS
CAPAN-1 M4e0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;2XINKSzVyPUCuOVIzQDhizszN NG\O[FNUSU6JRWK=
SK-OV-3 NWGyNFczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Pn[mlEPTB;MD61NlQ{PCEQvF2= M2rLeXNCVkeHUh?=
HuP-T3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX3VI1OUUN3ME2wMlUzQDJ5IN88US=> M{XsSXNCVkeHUh?=
NCI-H838 Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH2OVhKSzVyPUCuOVI5PDlizszN MWPTRW5ITVJ?
K5 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;qTWM2OD1yLkWzNlAyKM7:TR?= NXnOO4pmW0GQR1XS
CAL-72 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTpbXlKSzVyPUCuOVM{QDdizszN NWjxcHh5W0GQR1XS
NH-12 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn5TWM2OD1yLkWzPVU6KM7:TR?= Mn\VV2FPT0WU
SNB75 NHfIeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\6V5NKSzVyPUCuOVU4OyEQvF2= NFviPFNUSU6JRWK=
BPH-1 Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTJTWM2OD1yLkW2N|Q1KM7:TR?= MUTTRW5ITVJ?
NOMO-1 Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6zOmZKSzVyPUCuOVY{PzJizszN MlnvV2FPT0WU
G-402 NGf3WplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfuTWM2OD1yLkW2OFk6KM7:TR?= NYnQcXN1W0GQR1XS
NCI-H2052 NIfrc3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnnOG5KSzVyPUCuOVY4PDFizszN NW\4WlZ5W0GQR1XS
RCM-1 Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTJU41oUUN3ME2wMlU4OTZ4IN88US=> NHHCOoJUSU6JRWK=
COR-L279 M{fBU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHa[2E6UUN3ME2wMlU4OTh3IN88US=> MXzTRW5ITVJ?
A253 M1;xPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULsXGF5UUN3ME2wMlU4PTJ3IN88US=> NYfle2Q1W0GQR1XS
SK-MM-2 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1qwUmlEPTB;MD61O|Y4QSEQvF2= NF;adppUSU6JRWK=
NCI-H1703 NFjMZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwNUm0Nlch|ryP MmfBV2FPT0WU
UACC-257 NH7a[lhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;KRnk{UUN3ME2wMlU6PDh5IN88US=> M4nwUXNCVkeHUh?=
KALS-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjRWpJKSzVyPUCuOlAxOTFizszN MXvTRW5ITVJ?
ES5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETI[YxKSzVyPUCuOlA1QCEQvF2= MmLuV2FPT0WU
MHH-CALL-2 NWW1VWJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XVU2lEPTB;MD62NFg5QCEQvF2= MoDhV2FPT0WU
ChaGo-K-1 NUP0W3NWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHTTWM2OD1yLk[xNlI6KM7:TR?= M{HwSXNCVkeHUh?=
TGBC1TKB MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\WelhKSzVyPUCuOlE6QCEQvF2= NE\3XY5USU6JRWK=
KU-19-19 NYG2bG4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjhTndXUUN3ME2wMlY1PTh4IN88US=> NFywUI9USU6JRWK=
COLO-684 NEfscHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\3PWlEPTB;MD62OVYyOSEQvF2= NVrzN|hnW0GQR1XS
LS-1034 M3n5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwNkW4NVkh|ryP MX\TRW5ITVJ?
RT-112 NUHwcpN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml70TWM2OD1yLk[2OVg4KM7:TR?= NHSzd|RUSU6JRWK=
Capan-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jCR2lEPTB;MD62OlYzOiEQvF2= MUfTRW5ITVJ?
HSC-4 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLQUokzUUN3ME2wMlY3Pjl6IN88US=> M3fze3NCVkeHUh?=
COLO-824 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HleWlEPTB;MD62O|gzOyEQvF2= M3nYVnNCVkeHUh?=
NCI-H2170 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\ETWM2OD1yLk[4NlU5KM7:TR?= Mlq0V2FPT0WU
GDM-1 NYD3ZVlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfLc4xKSzVyPUCuOlg1QTRizszN M1;DN3NCVkeHUh?=
KP-4 NWLCWIFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\0d4ZoUUN3ME2wMlY6PTd|IN88US=> MlLZV2FPT0WU
VA-ES-BJ MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfHS2hvUUN3ME2wMlY6QTh4IN88US=> NIXsdZFUSU6JRWK=
KM-H2 M3rlN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OzTmlEPTB;MD63NFA6OSEQvF2= NXXQV4sxW0GQR1XS
HH MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwN{C2OlIh|ryP M4i2S3NCVkeHUh?=
DK-MG MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;GNJBIUUN3ME2wMlcyODF4IN88US=> NXzUTnp{W0GQR1XS
VM-CUB-1 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X1b2lEPTB;MD63NVI2QSEQvF2= MkPrV2FPT0WU
COLO-829 NVXqUIE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3VTWM2OD1yLkexPVg2KM7:TR?= NFrm[WNUSU6JRWK=
OMC-1 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPETWM2OD1yLkeyNVA1KM7:TR?= MYnTRW5ITVJ?
NB12 NH;J[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX2NINZUUN3ME2wMlczPTB2IN88US=> M{jjdXNCVkeHUh?=
NCI-H28 Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfhWo1KSzVyPUCuO|QxQDNizszN M2DQUXNCVkeHUh?=
A673 M{PUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwN{WxO|ch|ryP NV:wcXBXW0GQR1XS
LB2241-RCC NWrXfo82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nQVWlEPTB;MD63OlA5PyEQvF2= NFS5WYZUSU6JRWK=
CCRF-CEM MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;WNYExUUN3ME2wMlc4ODV{IN88US=> NXvLbWR[W0GQR1XS
NCI-H510A MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TSSmlEPTB;MD63O|E5PiEQvF2= NI\rcFRUSU6JRWK=
SW48 M4rxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1voN2lEPTB;MD63O|M{OyEQvF2= NH;1NpBUSU6JRWK=
NCI-H2081 NITFPI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwN{ixOFch|ryP MlHBV2FPT0WU
RMG-I NXnuWpRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrJVVZKSzVyPUCuO|gzOTJizszN NHTnVGZUSU6JRWK=
LU-99A NU[5Z4VJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwN{i0NVMh|ryP NVLGWm85W0GQR1XS
KP-N-YS NVnGV3RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHKTWM2OD1yLke4PVIyKM7:TR?= NV\MUIUyW0GQR1XS
MDA-MB-231 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnkTZNNUUN3ME2wMlgxOTNzIN88US=> NIXYV3NUSU6JRWK=
U031 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLSTWM2OD1yLkixOFI{KM7:TR?= NVnXSXhJW0GQR1XS
EVSA-T NEfoTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ubXJKSzVyPUCuPFE3PzJizszN MkC0V2FPT0WU
MDA-MB-157 MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS1TWM2OD1yLkiyNlcyKM7:TR?= MYnTRW5ITVJ?
EHEB M2\TTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrXcmZTUUN3ME2wMlgzOjd4IN88US=> MoC3V2FPT0WU
KINGS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwOEK1OVUh|ryP MVXTRW5ITVJ?
23132-87 NILre4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfmTWM2OD1yLkiyPFQ{KM7:TR?= MV3TRW5ITVJ?
EFO-21 NXP1WIJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwOESwPFkh|ryP MUfTRW5ITVJ?
DOK MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjPVlFXUUN3ME2wMlg1QCEQvF2= MmnJV2FPT0WU
NCI-H2171 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD2cWZYUUN3ME2wMlg1QTZizszN MVnTRW5ITVJ?
NCI-SNU-5 M2fkSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzUWpFKSzVyPUCuPFU2PyEQvF2= NG[x[2xUSU6JRWK=
SK-N-DZ MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDVTWM2OD1yLki1PVQ{KM7:TR?= NXHVVpNuW0GQR1XS
SNU-C2B NF71XGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TCVWlEPTB;MD64OlgxOSEQvF2= M4HG[XNCVkeHUh?=
CP66-MEL NV36VXZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzWWWI4UUN3ME2wMlg4OTFizszN NF\3fHhUSU6JRWK=
SN12C MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7pTWM2OD1yLki4OlM4KM7:TR?= M3my[XNCVkeHUh?=
A172 M4PkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HuOWlEPTB;MD64PFY6QCEQvF2= MkPIV2FPT0WU
NCI-H2347 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwOEi3OVMh|ryP NIjkT4pUSU6JRWK=
NCI-H2228 NX;ncJBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETKWXVKSzVyPUCuPFk{OzlizszN MXvTRW5ITVJ?
SNU-387 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrmNGhLUUN3ME2wMlkxOjZ2IN88US=> NXrwNIpqW0GQR1XS
SK-MEL-24 NHPoTXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLVVGdKSzVyPUCuPVE{PDRizszN MYrTRW5ITVJ?
MDA-MB-468 NXTNbJRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHje|FKSzVyPUCuPVE4OyEQvF2= NVfXfItuW0GQR1XS
NCI-H1694 NHn5RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwOUG4O|Yh|ryP MnTsV2FPT0WU
CCF-STTG1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrYTHRDUUN3ME2wMlkzPjN5IN88US=> NUXHc|NsW0GQR1XS
K052 NFHmNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkniTWM2OD1yLkm0NFQ4KM7:TR?= MoXBV2FPT0WU
NCI-H446 Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjW[G9KSzVyPUCuPVUxOSEQvF2= NWXzNGhbW0GQR1XS
MFE-280 M4DCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwOU[yPVEh|ryP NIriN5VUSU6JRWK=
KU812 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfiRnRFUUN3ME2wMlk6Ozh7IN88US=> NHuwTJFUSU6JRWK=
MDA-MB-361 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwOUm3O|ch|ryP MoH4V2FPT0WU
Raji NU\xdG53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjvNGU{UUN3ME2xMlAzOjZ5IN88US=> NUO0d5lDW0GQR1XS
TE-6 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwMEO1OlYh|ryP MUjTRW5ITVJ?
CAL-148 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTFwMES0OFMh|ryP MnTMV2FPT0WU
NCI-H1963 NXvONlJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYryfnVEUUN3ME2xMlA1PTV|IN88US=> NV23T2xJW0GQR1XS
SK-N-AS NXm3OJplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnCN25KSzVyPUGuNFQ3QDVizszN NGfSRlRUSU6JRWK=
RERF-LC-MS NFLmeplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwME[zOFkh|ryP Moj6V2FPT0WU
BEN NXzmVGgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXu3OmlwUUN3ME2xMlA4OTN5IN88US=> MmDEV2FPT0WU
CAS-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnnPWxkUUN3ME2xMlA6OTJ|IN88US=> M2q2cHNCVkeHUh?=
SW780 NUfC[|FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPETWM2OD1zLkC5NVgyKM7:TR?= MYHTRW5ITVJ?
LU-65 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPvTWM2OD1zLkC5OFEh|ryP NHHMdVVUSU6JRWK=
D-283MED MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOwNIp3UUN3ME2xMlEzOjd{IN88US=> NVTobGNOW0GQR1XS
HCC2157 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C2SmlEPTB;MT6xN|Y1OiEQvF2= MojiV2FPT0WU
RCC10RGB NWXHfGY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjmNmVKSzVyPUGuNVQxODZizszN M{Xvb3NCVkeHUh?=
PLC-PRF-5 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\sTWM2OD1zLkG1NlI6KM7:TR?= MojxV2FPT0WU
H4 NF\XS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjENYZKSzVyPUGuNVU1OzlizszN MkDxV2FPT0WU
TUR M3zydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoD4TWM2OD1zLkG1O|UzKM7:TR?= NX[4T|QzW0GQR1XS
NCI-H2141 M3i2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;FeVVtUUN3ME2xMlE5QTR4IN88US=> Mn\ZV2FPT0WU
PFSK-1 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjoPZhKSzVyPUGuNlA2OzJizszN MlTVV2FPT0WU
SK-MEL-28 M3jwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTFwMkOyNlEh|ryP M4\PPHNCVkeHUh?=
SCC-9 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\OZWlEPTB;MT6yN|Y3PSEQvF2= NHG3ZXRUSU6JRWK=
T47D MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwMkO2PVYh|ryP Mnj4V2FPT0WU
TCCSUP M1PRSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j4[WlEPTB;MT6yOVAzQSEQvF2= NXjEb|ZbW0GQR1XS
SU-DHL-1 NID5T3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqxbYZKSzVyPUGuNlUyOThizszN MoDCV2FPT0WU
HL-60 M13ZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwMkW1PFgh|ryP M3XhVXNCVkeHUh?=
NCI-H1436 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HsT2lEPTB;MT6yOlE1QSEQvF2= MnOwV2FPT0WU
DMS-114 NVG4d2RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXpeZhWUUN3ME2xMlI3PjN{IN88US=> MlHTV2FPT0WU
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MS-1 NUDkRmRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTzTWM2OD1zLkK5NFY6KM7:TR?= NWDRUZVEW0GQR1XS
NCI-H661 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTFwM{C0O|gh|ryP MV7TRW5ITVJ?
HT-3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vj[mlEPTB;MT6zNFUzQSEQvF2= M1vYXnNCVkeHUh?=
CAL-54 M1fudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX3[XpuUUN3ME2xMlMxPzJ3IN88US=> MkL1V2FPT0WU
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COLO-668 MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVO5U3BsUUN3ME2xMlM{ODV4IN88US=> MkLnV2FPT0WU
PANC-08-13 NHvzcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe2ZXJKSzVyPUGuN|M5ODNizszN MorqV2FPT0WU
BB49-HNC NHO4T2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jhemlEPTB;MT6zOFAyKM7:TR?= M2\lbHNCVkeHUh?=
M059J NULoNnB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3wSnU3UUN3ME2xMlM2QDN{IN88US=> MnnuV2FPT0WU
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UMC-11 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn2SlZQUUN3ME2xMlM6QTl4IN88US=> M1\FenNCVkeHUh?=
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CHP-126 NHfUV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTFwNU[2PVEh|ryP MVnTRW5ITVJ?
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NCI-H1304 NEP6RY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPvfWZyUUN3ME2xMlY{PTlzIN88US=> M1PpTXNCVkeHUh?=
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NCI-H716 NYTFN2FDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvSbY9[UUN3ME2xMlY6OzB2IN88US=> NY\tWldUW0GQR1XS
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HCC1187 NF;KZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrEenlqUUN3ME2xMlcxPTR3IN88US=> MmLzV2FPT0WU
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MKN7 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\uNW9KSzVyPUGuPFkzOiEQvF2= MXfTRW5ITVJ?
LAN-6 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTFwOEm1OVMh|ryP M2DLTHNCVkeHUh?=
Mo-T MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwOUCwN|kh|ryP MnrmV2FPT0WU
HCC1395 NVHMT2RvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLZbXhkUUN3ME2xMlkzQDZ|IN88US=> NEm1SJFUSU6JRWK=
HC-1 MknyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTFwOUO0O{DPxE1? M374cHNCVkeHUh?=
HPAF-II NXO5[pB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTFwOUS0NVgh|ryP MmLqV2FPT0WU
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MKN45 NGjDTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTFwOUmxNVkh|ryP M{DNOXNCVkeHUh?=
NCI-H1693 M{nPVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfDTWM2OD1{LkCwOFM{KM7:TR?= MlrHV2FPT0WU
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NCI-H1522 NEDXT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7zNI5KSzVyPUKuNFE4OjRizszN M4joZ3NCVkeHUh?=
SW1573 MoLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFi1dZNKSzVyPUKuNFIzKM7:TR?= NYPkU5lWW0GQR1XS
DBTRG-05MG MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDxTWM2OD1{LkC2NFg4KM7:TR?= MXrTRW5ITVJ?
SCC-4 NHnpemdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPOV25KSzVyPUKuNVQ{OSEQvF2= NWCySFhFW0GQR1XS
DMS-153 NWXFTlc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV63PZNUUUN3ME2yMlE3PjZ6IN88US=> MmDLV2FPT0WU
MDA-MB-415 NFjHO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDYdJlKSzVyPUKuNVc2OiEQvF2= MorOV2FPT0WU
NCI-H2126 M{PqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPlbIZMUUN3ME2yMlIzQDh6IN88US=> NHS2TJFUSU6JRWK=
MDA-MB-453 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojRTWM2OD1{LkKzN|Ih|ryP M{Py[XNCVkeHUh?=
U-87-MG MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT1TWM2OD1{LkK4OVkzKM7:TR?= M1q3S3NCVkeHUh?=
LNCaP-Clone-FGC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HG[GlEPTB;Mj6zNFExOiEQvF2= M{PSfXNCVkeHUh?=
NCI-H1581 NEP2RlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfKTWM2OD1{LkOyNVA2KM7:TR?= NGXtbHpUSU6JRWK=
BC-3 NF3welZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTlXFV4UUN3ME2yMlM3PTB7IN88US=> MnXmV2FPT0WU
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RO82-W-1 NEjiSZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjrWm5KSzVyPUKuOFEzPSEQvF2= MVLTRW5ITVJ?
C2BBe1 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37QcGlEPTB;Mj60NVU4QCEQvF2= MXLTRW5ITVJ?
LAMA-84 NFLnbZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH6TWM2OD1{LkW3N|Y5KM7:TR?= MoT2V2FPT0WU
GMS-10 MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLpTWM2OD1{LkW3OlEyKM7:TR?= NV;YVW9XW0GQR1XS
GCT NHv6do9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\CU2UzUUN3ME2yMlU5Pjl2IN88US=> MWPTRW5ITVJ?
SK-CO-1 NFHZN2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P2OWlEPTB;Mj62NVY3KM7:TR?= MonHV2FPT0WU
NCI-H526 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37NdmlEPTB;Mj62N|Q2KM7:TR?= MXTTRW5ITVJ?
SW1088 M37NWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwN{e4N|kh|ryP NWDP[m1JW0GQR1XS
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NB10 MljpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nzRmlEPTB;Mj64NVc1QCEQvF2= NHviVI5USU6JRWK=
UACC-893 NH:ySpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJwOEW3OFkh|ryP NWrEN3VrW0GQR1XS
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SBC-1 M4HvUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnFRndKSzVyPUOuNFg2PTNizszN NULFNFZKW0GQR1XS
NCI-H1623 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNwMEmzOEDPxE1? NF;WWlVUSU6JRWK=
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D-263MG NX[3elJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrFb5Q2UUN3ME2zMlE1Pzh6IN88US=> MnvlV2FPT0WU
NCI-H1573 M1jKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfKeY1EUUN3ME2zMlE6PjRzIN88US=> NEjQR41USU6JRWK=
NCI-H82 M4\6O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\DT|dlUUN3ME2zMlM1PDN7IN88US=> MlexV2FPT0WU
NCI-H2196 NH\2[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTNwM{WwNFgh|ryP NH3B[5pUSU6JRWK=
MFM-223 NYTtOFVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFOxbZFKSzVyPUOuN|c{PTFizszN MoH4V2FPT0WU
COLO-678 NE[y[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPPSIlKSzVyPUOuN|gyQDZizszN NIe0NYpUSU6JRWK=
EW-3 M4CwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTNwNEC5OUDPxE1? NVvCW3VZW0GQR1XS
MHH-NB-11 NWfjU5NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTVcIt[UUN3ME2zMlQ1ODZ7IN88US=> NEG3[mNUSU6JRWK=
EM-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n4cmlEPTB;Mz62N|k5KM7:TR?= NVjQOmlPW0GQR1XS
FTC-133 M{DtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy4c2pKSzVyPUOuOlU1PThizszN NIPSb3NUSU6JRWK=
NCI-H209 NUDwWGprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXvTWM2OD1|Lk[3OlU{KM7:TR?= M3K5[HNCVkeHUh?=
TGBC24TKB MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXMV4RKSzVyPUOuOlg{PTVizszN MknQV2FPT0WU
LC-1F NWTMU2I6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorDTWM2OD1|LkexO|Y1KM7:TR?= MonIV2FPT0WU
C-4-II NX;hT2VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLMb2hKSzVyPUOuO|U3PDNizszN MVfTRW5ITVJ?
NCI-H1650 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nyOWlEPTB;Mz63PFQ2PSEQvF2= M1rCdXNCVkeHUh?=
JVM-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37oUmlEPTB;Mz65N|Y{QSEQvF2= NGP1SoVUSU6JRWK=
CaR-1 NXXubXR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DBNmlEPTB;Mz65O|YyPyEQvF2= NW\lXnZuW0GQR1XS
MDA-MB-134-VI Mlz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLPTWM2OD12LkCyPVUzKM7:TR?= M{fPbnNCVkeHUh?=
NCI-H719 NXrXSFRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYraXVR1UUN3ME20MlE2Ozh6IN88US=> Ml:yV2FPT0WU
GOTO M{fzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLWVFNkUUN3ME20MlI6PzB3IN88US=> M4nrU3NCVkeHUh?=
NCI-N87 MmHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jxbmlEPTB;ND6zPFgzOSEQvF2= M1:1NXNCVkeHUh?=
NB6 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX4ToFCUUN3ME20MlQzPTB7IN88US=> MUfTRW5ITVJ?
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BT-20 MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\jTWM2OD12LkS5NFAzKM7:TR?= M1fEOXNCVkeHUh?=
NCI-H1882 NV[yTndJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrKTWM2OD12LkWwOVch|ryP NIH3eodUSU6JRWK=
WM-115 Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTRwNUC4PFEh|ryP MWPTRW5ITVJ?
SKG-IIIa NEfuTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrDcWZOUUN3ME20MlY4PzdizszN NUjwU|JXW0GQR1XS
NCI-H69 M2C1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTRwN{CyO|Uh|ryP Mlr4V2FPT0WU
MSTO-211H MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHaTWM2OD12LkizOVY2KM7:TR?= M2TzOXNCVkeHUh?=
Mewo NHjWV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRwOU[zNVMh|ryP NX7J[XNjW0GQR1XS
GI-ME-N NXH1[JU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TVTmlEPTB;NT6wNFUxQSEQvF2= NF:yOWxUSU6JRWK=
T98G NHf6U4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC2U2hOUUN3ME21MlA3PTB6IN88US=> Mn3sV2FPT0WU
ECC4 NHPzeFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlOwTWM2OD13LkC5N|czKM7:TR?= NIrGOXRUSU6JRWK=
EW-11 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTVwMUiwPVkh|ryP MXvTRW5ITVJ?
COLO-800 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLne|FiUUN3ME21MlE6OzR7IN88US=> MXfTRW5ITVJ?
NCI-H1755 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTVwMkOwNlch|ryP M4HReHNCVkeHUh?=
KMS-12-PE NF3CNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDzTWM2OD13LkO1NFg2KM7:TR?= M3GzRnNCVkeHUh?=
HCC1954 NEjXSVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTVwOEW5O|Eh|ryP M{i1[3NCVkeHUh?=
NCI-H187 Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm1[nY{UUN3ME21MlkzQTh7IN88US=> MkHWV2FPT0WU
LU-165 NYDmcm1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TCSWlEPTB;NT65PVAxOiEQvF2= NWPZNnBJW0GQR1XS
YAPC NUHveoZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[2fmlEPTB;NT65PVA3QCEQvF2= NUPLNG4{W0GQR1XS
LU-139 NFTETI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXEW49KSzVyPU[uNFg{PjhizszN MmPoV2FPT0WU
D-502MG M4jBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;KTWM2OD14LkOyNFQ4KM7:TR?= MUfTRW5ITVJ?
IST-SL1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLGTWM2OD14LkWzPVQ5KM7:TR?= M4qz[3NCVkeHUh?=
DG-75 NFLnSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrC[GpwUUN3ME22Mlg5Pzh4IN88US=> NH62eHBUSU6JRWK=
NCI-H1155 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPsXGNKSzVyPU[uPVU2QDFizszN NEnTVIpUSU6JRWK=
EFE-184 M4jCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTsTWM2OD15LkOxOlk2KM7:TR?= NYDrSodSW0GQR1XS
AsPC-1 MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHOWFl7UUN3ME23MlQ5QDB5IN88US=> MmjEV2FPT0WU
SW948 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y0PWlEPTB;Nz61PFM6PSEQvF2= M4nHTXNCVkeHUh?=
NCI-H524 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTlwNUi2Nlgh|ryP MmK3V2FPT0WU
KOSC-2 NHGxTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HtVmlEPTB;OT62Nlg{PCEQvF2= NVTNT4hwW0GQR1XS
T-24 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfjdYtKSzVyPUmuPVQ1OTVizszN MUXTRW5ITVJ?
NCI-H748 M3vycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[5W|RbUUN3ME2xNE43Ozl5IN88US=> MXzTRW5ITVJ?
NCI-H23 M4XFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDRPHpYUUN3ME2xNE43PDR{IN88US=> NVfwfXFsW0GQR1XS
UACC-812 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKwcJhzUUN3ME2xNU44OTdizszN M1n6fnNCVkeHUh?=
SCLC-21H NWS2[WtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF{LkG1OVEh|ryP NEfibJNUSU6JRWK=
NCI-SNU-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTYTWM2OD1zMz6xNlU5KM7:TR?= NWXPcJlNW0GQR1XS
HD-MY-Z NY\kVGJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF2Lk[zOlMh|ryP NVfSUYw3W0GQR1XS
SK-N-FI MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nTNmlEPTB;MUSuPFkyOiEQvF2= NWjUfIdmW0GQR1XS
LB647-SCLC MnfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTF3LkexPVUh|ryP M1LnS3NCVkeHUh?=
NCI-H345 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jvfGlEPTB;MUeuN|Q{KM7:TR?= MXLTRW5ITVJ?
NCI-H1563 MnTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF6Lke2NFEh|ryP MX3TRW5ITVJ?
RL MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJzLkK2OVYh|ryP NH64UW1USU6JRWK=
KY821 NX3SOmp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETvUWNKSzVyPUKyMlA2PTNizszN NXjLeWJOW0GQR1XS
JVM-3 NGX5UndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPKeVcxUUN3ME2yOU4xPDF|IN88US=> MV3TRW5ITVJ?
NCI-H1793 M3PoNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XheWlEPTB;MkiuOVQ6QSEQvF2= NWjhRVBZW0GQR1XS
LU-134-A NY\INZdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTNyLkKwN|ch|ryP M2TXR3NCVkeHUh?=
NCI-H1395 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\1NotvUUN3ME2zNk4zPDNzIN88US=> M3PSfHNCVkeHUh?=
NCI-H1993 NGHJcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTN{LkiyNVgh|ryP MkPjV2FPT0WU
P31-FUJ M3PhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{WxXWlEPTB;M{OuOFg6QSEQvF2= MnvhV2FPT0WU
LS-513 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\KdWlEPTB;M{WuPFg4QSEQvF2= NIrsUFBUSU6JRWK=
SK-MEL-1 M3;DWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTRyLkO0PVkh|ryP MXPTRW5ITVJ?
SW684 NGLqVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX6cZpwUUN3ME20N{46PjZzIN88US=> NHfzTZpUSU6JRWK=
COR-L88 M1\idmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG2TWM2OD12ND6wOlY2KM7:TR?= M{fFb3NCVkeHUh?=
NCI-H889 M2\Ce2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TTdmlEPTB;NEWuNFA5PyEQvF2= NVfaW|VqW0GQR1XS
TALL-1 NHfGZ5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXwVWpKSzVyPUS2MlEyQTlizszN MnLNV2FPT0WU
KARPAS-299 M3jmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK5ZopKSzVyPUS3MlE6QTNizszN Mn;1V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID