Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Cited by 51 Publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXV[WJKSzVyPUCuNFAxODNzNzFOwG0> M{S1e3NCVkeHUh?=
SK-MEL-30 NG\CdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrRVoNKSzVyPUCuNFAxOzV3IN88US=> NXT3fWpiW0GQR1XS
NALM-6 MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK1OIl{UUN3ME2wMlAxODN3NjFOwG0> NWfGWXk6W0GQR1XS
KYSE-450 NFfRZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLZTWM2OD1yLkCwNFQ3QSEQvF2= MkWyV2FPT0WU
BHY MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfwTWM2OD1yLkCwNFYxOSEQvF2= NEKxN5FUSU6JRWK=
GR-ST NFnT[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjHXWRKSzVyPUCuNFAxPjR6IN88US=> MmH0V2FPT0WU
786-0 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDYTWM2OD1yLkCwNFc4PiEQvF2= MkSzV2FPT0WU
C-33-A NF;lXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMECwPFQ5KM7:TR?= MnzFV2FPT0WU
BHT-101 M3rqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKyV2pKSzVyPUCuNFAyODZizszN MYXTRW5ITVJ?
EB2 NXzr[FM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfmSFE6UUN3ME2wMlAxOTF6IN88US=> NVLuNFVOW0GQR1XS
G-361 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXNTWM2OD1yLkCwNVI1KM7:TR?= M3TmZ3NCVkeHUh?=
KE-37 MlPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fHV2lEPTB;MD6wNFEzQCEQvF2= NW[2eGlEW0GQR1XS
MHH-PREB-1 NYTIRXBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\jTWM2OD1yLkCwNVQh|ryP NEHsTI1USU6JRWK=
MCF7 Mlr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOxb2lKSzVyPUCuNFAyPTlizszN NEjxWpBUSU6JRWK=
LOUCY NWrxXmZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\tOmlEPTB;MD6wNFE4PSEQvF2= MYTTRW5ITVJ?
EW-7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;yTWM2OD1yLkCwNVc2KM7:TR?= MYfTRW5ITVJ?
KYSE-510 M1XudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXqTWM2OD1yLkCwNlM{KM7:TR?= NILJZ5lUSU6JRWK=
SK-MEL-3 M4PDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzRbmVKSzVyPUCuNFAzPjRizszN NILO[JlUSU6JRWK=
HAL-01 M{nVfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHSPW1KSzVyPUCuNFAzQTdizszN NFu5bphUSU6JRWK=
HCC2998 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMECzN|Uh|ryP NH3ZU3NUSU6JRWK=
A375 NGjQTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfo[VVKSzVyPUCuNFA{PSEQvF2= Mn3CV2FPT0WU
MZ7-mel NVnUcGdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULLUGxbUUN3ME2wMlAxOzl7IN88US=> Ml3LV2FPT0WU
SH-4 NHvxcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle4TWM2OD1yLkCwOFE4KM7:TR?= MUjTRW5ITVJ?
HT-144 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEC0N{DPxE1? MkHZV2FPT0WU
KYSE-140 M4nlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTvTWM2OD1yLkCwOFM2KM7:TR?= M4jKW3NCVkeHUh?=
PSN1 NFnve3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS4WI9[UUN3ME2wMlAxPDZ5IN88US=> MVnTRW5ITVJ?
COLO-679 NGi4blZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT0TWM2OD1yLkCwOFk5KM7:TR?= MWHTRW5ITVJ?
SW620 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;5TWM2OD1yLkCwOVEyKM7:TR?= MkTKV2FPT0WU
HGC-27 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEC1NlQh|ryP NUjQW3BSW0GQR1XS
IGROV-1 M3nyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2H0R2lEPTB;MD6wNFYh|ryP MX;TRW5ITVJ?
IGR-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnnSY1KSzVyPUCuNFA3ODFizszN M1nyVHNCVkeHUh?=
EW-1 NFLxfVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MniyTWM2OD1yLkCwOlUyKM7:TR?= M1XPd3NCVkeHUh?=
769-P NVLuR3pET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEC2O|gh|ryP M{HsUHNCVkeHUh?=
HN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;kTWM2OD1yLkCwOlc6KM7:TR?= M1fQUXNCVkeHUh?=
SIG-M5 NI\VVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DQXGlEPTB;MD6wNFcyKM7:TR?= MnrQV2FPT0WU
IST-MEL1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Gy[GlEPTB;MD6wNFgyQCEQvF2= M17RVHNCVkeHUh?=
ST486 M4i1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrlTWM2OD1yLkCwPFI2KM7:TR?= MWjTRW5ITVJ?
ES7 MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHGcIxKSzVyPUCuNFA5PDZizszN MlvtV2FPT0WU
GAK MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2W5emlEPTB;MD6wNFg1QCEQvF2= NHfNUpFUSU6JRWK=
BB30-HNC NWS2[IFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPtdGJKSzVyPUCuNFA5PThizszN NV7YV29yW0GQR1XS
IPC-298 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33EO2lEPTB;MD6wNFkzPyEQvF2= MX7TRW5ITVJ?
NKM-1 M2Ls[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7vN4FKSzVyPUCuNFA6PzJizszN NIe3cJRUSU6JRWK=
RKO NIXIdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HHS2lEPTB;MD6wNVA1PCEQvF2= MXXTRW5ITVJ?
ACN M4noeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH3fFVLUUN3ME2wMlAyOTNzIN88US=> NIrEPZBUSU6JRWK=
SW1417 MkG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrwc25KSzVyPUCuNFEzOjVizszN NUnWXoNsW0GQR1XS
SR NFzWd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLGOm1KSzVyPUCuNFEzOzVizszN NFzsT5pUSU6JRWK=
SNG-M MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHIT5BKSzVyPUCuNFE{OTdizszN MVjTRW5ITVJ?
CAL-12T NYn3Z|hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W0WWlEPTB;MD6wNVM1PiEQvF2= M1Tj[XNCVkeHUh?=
HSC-3 NUjqcopoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPL[npQUUN3ME2wMlAyOzV3IN88US=> NVWyTo9lW0GQR1XS
DOHH-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Wx[2lEPTB;MD6wNVQyOiEQvF2= Ml25V2FPT0WU
NB69 NXXTTJdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLsPVU1UUN3ME2wMlAyPTZ3IN88US=> MlvEV2FPT0WU
LC-2-ad MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTQTWM2OD1yLkCxOVgyKM7:TR?= NX6yVHprW0GQR1XS
RVH-421 NVS5PFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHMXpg6UUN3ME2wMlAyPjd2IN88US=> M3voSHNCVkeHUh?=
TGW NGj6XIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M123U2lEPTB;MD6wNVc{QSEQvF2= MlzkV2FPT0WU
HCC1569 M1rnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GyemlEPTB;MD6wNVc6PyEQvF2= NIL2U|RUSU6JRWK=
CAL-85-1 MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6zTWM2OD1yLkCxPFMzKM7:TR?= NIHaendUSU6JRWK=
RPMI-8402 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH4TWM2OD1yLkCxPFU5KM7:TR?= M4nmWXNCVkeHUh?=
THP-1 NGPRe2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rlfGlEPTB;MD6wNVk6QCEQvF2= MVvTRW5ITVJ?
ONS-76 Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XJSmlEPTB;MD6wNlA{PiEQvF2= MmTOV2FPT0WU
A2780 Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH5VVdKSzVyPUCuNFIxPzlizszN NWfKNIZlW0GQR1XS
RPMI-2650 M2XoOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPoTWM2OD1yLkCyNlk3KM7:TR?= NUiyR4I3W0GQR1XS
MEL-HO Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnqXJZKSzVyPUCuNFI{PDhizszN NInHd3VUSU6JRWK=
MC-CAR MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXQTWZPUUN3ME2wMlAzOzV4IN88US=> MVvTRW5ITVJ?
HSC-2 M4\SeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nUJRNUUN3ME2wMlAzPDZ4IN88US=> M3rMT3NCVkeHUh?=
MEL-JUSO MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPBN5R[UUN3ME2wMlAzPDd|IN88US=> MoO3V2FPT0WU
CAL-62 NWjSe|NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jndWlEPTB;MD6wNlYxOiEQvF2= NYm5O|VGW0GQR1XS
DMS-273 MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEK4OFch|ryP NHfFWpRUSU6JRWK=
S-117 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDOTWM2OD1yLkCyPVA3KM7:TR?= NY\XbJNyW0GQR1XS
SUP-T1 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m3W2lEPTB;MD6wNlk1QSEQvF2= NWflXG46W0GQR1XS
MZ2-MEL MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPTTWM2OD1yLkCyPVU6KM7:TR?= MXrTRW5ITVJ?
KYSE-270 NYWySWhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrVTWM2OD1yLkCyPVc3KM7:TR?= M17IbHNCVkeHUh?=
CMK MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEOwNlMh|ryP NVG2OFUxW0GQR1XS
8505C MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjvcGZKSzVyPUCuNFMxPCEQvF2= M1z0S3NCVkeHUh?=
NUGC-3 MmnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfJZ|ZKSzVyPUCuNFMxPDhizszN MUjTRW5ITVJ?
A101D NHnLR5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PGZmlEPTB;MD6wN|A2PSEQvF2= M2n5RnNCVkeHUh?=
G-401 MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEOwPVMh|ryP M2nNN3NCVkeHUh?=
OVCAR-8 MlnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Sxc2lEPTB;MD6wN|ExPyEQvF2= NIi1SXBUSU6JRWK=
IMR-5 MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTySVJKSzVyPUCuNFMzPDRizszN Mn;qV2FPT0WU
DoTc2-4510 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PtOWlEPTB;MD6wN|M6OyEQvF2= NUGyU3dsW0GQR1XS
HOS MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrC[I9KSzVyPUCuNFM1PzNizszN M1[yfHNCVkeHUh?=
HEC-1 NVnNZ|dvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPITWM2OD1yLkCzOlgh|ryP M1KzbXNCVkeHUh?=
SW756 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Bd|RKSzVyPUCuNFM5OjFizszN NVHVUphKW0GQR1XS
NCI-H64 NYLCUZp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rwSmlEPTB;MD6wN|g1OiEQvF2= MXXTRW5ITVJ?
EW-16 NFXEVmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr4bIRKSzVyPUCuNFM6ODlizszN NEj0cY9USU6JRWK=
CAL-51 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDYTWM2OD1yLkC0NFA2KM7:TR?= NFHNfW5USU6JRWK=
KYSE-150 NFq2c4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Toc2lEPTB;MD6wOFAyOSEQvF2= NEfBXZhUSU6JRWK=
SW1710 NXvM[GIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDHTWM2OD1yLkC0NFE5KM7:TR?= NULkUolGW0GQR1XS
HuP-T4 NIHnbYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vy[2lEPTB;MD6wOFEyQCEQvF2= MmLxV2FPT0WU
LB373-MEL-D MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMESyN|Ih|ryP MnmxV2FPT0WU
EW-13 M1zzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXTcYVKSzVyPUCuNFQ1ODZizszN M2fBXXNCVkeHUh?=
HT-29 MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTIZ2tqUUN3ME2wMlA1PDlizszN NIXiOFJUSU6JRWK=
SCC-25 M{PoUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXKVmhiUUN3ME2wMlA1PDl2IN88US=> MoqzV2FPT0WU
REH NX:1c|RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\jPGlKSzVyPUCuNFQ3OzVizszN NYjYcHRqW0GQR1XS
L-363 NXPvUlIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrZflBKSzVyPUCuNFQ3PzlizszN NEjIdmhUSU6JRWK=
NCI-H1770 NEPhRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXCU3J[UUN3ME2wMlA1Pjl5IN88US=> M1nDSHNCVkeHUh?=
CHL-1 MkfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\TUZRMUUN3ME2wMlA1QDV5IN88US=> NX7nfJR5W0GQR1XS
ES1 NH75fpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMES4PFUh|ryP MmWwV2FPT0WU
SCC-15 MonOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMES5NFIh|ryP M13IRnNCVkeHUh?=
MRK-nu-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLNTWM2OD1yLkC0PVM3KM7:TR?= M2TpT3NCVkeHUh?=
PF-382 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDlTJp6UUN3ME2wMlA1QTN7IN88US=> NVy3R21SW0GQR1XS
COLO-680N MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPkSWFKSzVyPUCuNFUxPDdizszN NFPGfY1USU6JRWK=
LK-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTwTWM2OD1yLkC1NFY{KM7:TR?= NFrISGVUSU6JRWK=
NCI-H2342 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrodIpKSzVyPUCuNFUyOTdizszN MkXQV2FPT0WU
HMV-II MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXGeHkxUUN3ME2wMlA2OjN7IN88US=> NYDSW5BxW0GQR1XS
PC-14 M3nKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XlO2lEPTB;MD6wOVI2OiEQvF2= M1vpXHNCVkeHUh?=
COLO-320-HSR Mnj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMEWyPFkh|ryP MlntV2FPT0WU
697 MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMEWzNlMh|ryP MkjHV2FPT0WU
NEC8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW0WJRIUUN3ME2wMlA2PTlizszN MmPpV2FPT0WU
LCLC-97TM1 NHjL[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnlNXVKSzVyPUCuNFU2QTRizszN NVy2UXZLW0GQR1XS
Daoy M4q4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonPTWM2OD1yLkC1OlE3KM7:TR?= M1PlT3NCVkeHUh?=
ETK-1 NXHvZmw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fMbmlEPTB;MD6wOVY4OiEQvF2= MUfTRW5ITVJ?
A388 Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XoOmlEPTB;MD6wOVY6PSEQvF2= NGjwSGJUSU6JRWK=
COLO-205 NHTFRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX2TWM2OD1yLkC1O|E3KM7:TR?= NXPMVWluW0GQR1XS
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SF268 NVPjflZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17qU2lEPTB;MD6wOVc2PiEQvF2= M{fTOXNCVkeHUh?=
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D-542MG M{e0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDmWZk4UUN3ME2wMlE3QTh4IN88US=> MWPTRW5ITVJ?
EB-3 NFnU[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLvTWM2OD1yLkG3N|Eh|ryP Ml\6V2FPT0WU
HCC1143 NWLZXWFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4m1d2lEPTB;MD6xO|M6PiEQvF2= MVHTRW5ITVJ?
DJM-1 MlixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTlTWM2OD1yLkG3OFUyKM7:TR?= NHzjRoxUSU6JRWK=
BT-474 NXnncnlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPh[nJKSzVyPUCuNVc1QDlizszN M4LRRnNCVkeHUh?=
BB65-RCC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjMTWM2OD1yLkG3OVQ2KM7:TR?= NIrUSlBUSU6JRWK=
NCI-H292 NH23OWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUe2NFEh|ryP Mn3TV2FPT0WU
MKN28 NULuVFMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHxXlVKSzVyPUCuNVc3PTNizszN MXHTRW5ITVJ?
TK10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXCOnRUUUN3ME2wMlE4PzB{IN88US=> MXPTRW5ITVJ?
TYK-nu MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4H5fmlEPTB;MD6xO|k1QSEQvF2= NHfqUY9USU6JRWK=
8305C MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T5bmlEPTB;MD6xO|k4OSEQvF2= M1n2XHNCVkeHUh?=
MV-4-11 M{\HXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17jfGlEPTB;MD6xO|k4PyEQvF2= NXPlW5ZzW0GQR1XS
NCI-H522 M4nOWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH5TWM2OD1yLkG4NFk1KM7:TR?= MYDTRW5ITVJ?
Hs-578-T NIDUelFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS2UJhqUUN3ME2wMlE5Ojl{IN88US=> M2f3S3NCVkeHUh?=
LCLC-103H NHrOSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfOW5dKSzVyPUCuNVg2OjdizszN MYjTRW5ITVJ?
MHH-ES-1 Mmm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPCbZFKSzVyPUCuNVg3OjlizszN NYfuZ25WW0GQR1XS
NCI-H441 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMUmxOFgh|ryP MlW5V2FPT0WU
AM-38 M3;Xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULHblJYUUN3ME2wMlE6OjJ3IN88US=> MWfTRW5ITVJ?
SW1783 NYiwOoxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fzPGlEPTB;MD6xPVMxPSEQvF2= MoThV2FPT0WU
SK-HEP-1 NFXLOopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMUm2N|ch|ryP NEjuOFVUSU6JRWK=
OAW-28 M3zqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS2TWM2OD1yLkKwNVc5KM7:TR?= MmPXV2FPT0WU
TE-15 M{P1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTGPYpQUUN3ME2wMlIxOjV{IN88US=> NVHER|lKW0GQR1XS
HCE-4 M37X[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMkCyPFQh|ryP M4rtXnNCVkeHUh?=
JiyoyeP-2003 NEf1VmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrkdJVKSzVyPUCuNlA{OzZizszN M2HMXXNCVkeHUh?=
OVCAR-4 Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrTOJdKSzVyPUCuNlA3OjhizszN M1XUcXNCVkeHUh?=
SNU-449 NG\oZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHntfZdKSzVyPUCuNlA4QTdizszN NWLxdm97W0GQR1XS
SBC-5 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMkGyNVUh|ryP NIPx[2JUSU6JRWK=
T84 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fCN2lEPTB;MD6yNVI1QCEQvF2= NFvBe3pUSU6JRWK=
LP-1 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\mRplRUUN3ME2wMlIyOzB{IN88US=> NIPYdlJUSU6JRWK=
MG-63 NFzZfZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfITpJ1UUN3ME2wMlIyOzh{IN88US=> MkXMV2FPT0WU
OAW-42 NIH0[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vjcGlEPTB;MD6yNVQ4QCEQvF2= M2XDfXNCVkeHUh?=
L-540 Ml3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7TOmV[UUN3ME2wMlIyPTl6IN88US=> MXTTRW5ITVJ?
RH-1 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMkKyOFIh|ryP Ml;UV2FPT0WU
HCT-15 M3HzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWzfFd1UUN3ME2wMlIzPDh2IN88US=> M{jRR3NCVkeHUh?=
OCUB-M M4nROmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMkK0PFgh|ryP NI\CcmNUSU6JRWK=
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NCI-H2030 NUjh[|lUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonJTWM2OD1yLkKyO|M1KM7:TR?= M2TpSnNCVkeHUh?=
ML-2 MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vJWmlEPTB;MD6yNlg5QSEQvF2= M1nHRXNCVkeHUh?=
CAL-39 NG[zTnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\QeHFKSzVyPUCuNlI6OzZizszN M17CfnNCVkeHUh?=
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LB2518-MEL M4WxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW1SWJ2UUN3ME2wMlI{Ozd{IN88US=> M4jTR3NCVkeHUh?=
DB MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK3dnFbUUN3ME2wMlI{PDN6IN88US=> NYqwelVMW0GQR1XS
NCI-H596 M1X1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnzVG8xUUN3ME2wMlI{PTdzIN88US=> NEns[Y9USU6JRWK=
SW1990 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTuSoUzUUN3ME2wMlI{QTR4IN88US=> M2\0PXNCVkeHUh?=
P30-OHK NVrhUppYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\OWWtKSzVyPUCuNlQxPSEQvF2= NH;m[ppUSU6JRWK=
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Saos-2 NF\B[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXaTWM2OD1yLkK0OVcyKM7:TR?= MVfTRW5ITVJ?
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Calu-3 NV;EUGhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMkWyPVch|ryP MXPTRW5ITVJ?
HT MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMkW2NlEh|ryP NHfSOmJUSU6JRWK=
LXF-289 NXG5eIxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\me4lVUUN3ME2wMlI2QTh2IN88US=> Mm\VV2FPT0WU
KGN MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG1dXdyUUN3ME2wMlI3ODh7IN88US=> MV3TRW5ITVJ?
NCI-H1417 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3kdWRKSzVyPUCuNlY2OjRizszN MoK2V2FPT0WU
SF126 NVHtTGlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm1XWF6UUN3ME2wMlI4OzB{IN88US=> Mn\3V2FPT0WU
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GI-1 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LyZ2lEPTB;MD6yO|Q5PyEQvF2= MXHTRW5ITVJ?
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NB1 M4HjPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojlTWM2OD1yLkK3PFc3KM7:TR?= NHrOPVRUSU6JRWK=
NCI-H650 NWO2XnpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMkizNFIh|ryP MV;TRW5ITVJ?
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UM-UC-3 NWXhOJlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nrdmlEPTB;MD6yPVE1KM7:TR?= NIH4fVJUSU6JRWK=
CAL-120 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[4TWM2OD1yLkK5OlMyKM7:TR?= MVrTRW5ITVJ?
UACC-62 NIPLPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOy[mJKSzVyPUCuN|AzPDFizszN NF24botUSU6JRWK=
TE-11 MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ycVZKSzVyPUCuN|AzPDlizszN M1;vVXNCVkeHUh?=
MKN1 M3f0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz2U4JYUUN3ME2wMlMxOzZizszN NEDMWpNUSU6JRWK=
KS-1 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2SzVmlEPTB;MD6zNFUzPiEQvF2= NHLMZ3pUSU6JRWK=
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OVCAR-5 NFrVN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLBTWM2OD1yLkOxNVA3KM7:TR?= M2jmeHNCVkeHUh?=
U-266 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL5O3BzUUN3ME2wMlMyOTR5IN88US=> MXzTRW5ITVJ?
Calu-1 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzlXllJUUN3ME2wMlMyOjh7IN88US=> NXfHTYFKW0GQR1XS
SK-LMS-1 Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{G0Nlkh|ryP MU\TRW5ITVJ?
COLO-741 M4\xNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnS[XBKSzVyPUCuN|E3OTRizszN MmDNV2FPT0WU
RPMI-8226 NXfQTlZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHRRnhKSzVyPUCuN|E3PDFizszN M2XaTnNCVkeHUh?=
KM12 NGrm[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rMNWlEPTB;MD6zNVg{KM7:TR?= NViyVFZzW0GQR1XS
NMC-G1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PJUWlEPTB;MD6zNVg3KM7:TR?= NEjUbZlUSU6JRWK=
SJRH30 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm5TWM2OD1yLkOyNFUzKM7:TR?= MV\TRW5ITVJ?
COR-L105 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\hTHBrUUN3ME2wMlMzOjF6IN88US=> NF7FTZJUSU6JRWK=
IM-9 MkPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXTTWM2OD1yLkOzNFIyKM7:TR?= M2ryPXNCVkeHUh?=
TE-12 NXLMOJNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz3SmMzUUN3ME2wMlM{OzF5IN88US=> MlTJV2FPT0WU
KG-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[xTWM2OD1yLkOzOFMzKM7:TR?= MkHPV2FPT0WU
U251 NVG2PYVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fHcWlEPTB;MD6zN|Q2PiEQvF2= M2Ljc3NCVkeHUh?=
EFO-27 MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTxU2ZKSzVyPUCuN|M6PTFizszN NX\vXZQyW0GQR1XS
EW-24 NUK4VnQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;wdJkzUUN3ME2wMlM{QTh2IN88US=> Mn7NV2FPT0WU
SF295 NHnyc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH2TWM2OD1yLkOzPVk6KM7:TR?= M4qzXnNCVkeHUh?=
MC-IXC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHjUIRYUUN3ME2wMlM1PSEQvF2= MX;TRW5ITVJ?
NCI-H2405 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly1TWM2OD1yLkO0O|MzKM7:TR?= MWLTRW5ITVJ?
NCI-H2009 M{e1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXMflBKSzVyPUCuN|Q4OzlizszN NFzOc3BUSU6JRWK=
LB1047-RCC M4HPeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn61TWM2OD1yLkO1PFE2KM7:TR?= MkPIV2FPT0WU
KNS-81-FD Mn7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnJcHdKSzVyPUCuN|Y3PjdizszN NXTXTYxLW0GQR1XS
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C3A NUf5RnhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTtOHU3UUN3ME2wMlM4Ozd7IN88US=> NGDpc29USU6JRWK=
NCI-H1792 NGL2PGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;mcFgzUUN3ME2wMlM4PjV3IN88US=> NUDQOYp3W0GQR1XS
HuH-7 M3TvbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW1TWM2OD1yLkO3PVEh|ryP Mni1V2FPT0WU
AGS NIXjZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1WydGlEPTB;MD6zPFY{QCEQvF2= NUmyZ|RzW0GQR1XS
HT-1197 M1H2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Lo[mlEPTB;MD6zPVQ3KM7:TR?= MUnTRW5ITVJ?
CGTH-W-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\YTWM2OD1yLkO5PVE{KM7:TR?= MVLTRW5ITVJ?
KNS-42 Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW3TWM2OD1yLkSwNFQ2KM7:TR?= NFnNe|FUSU6JRWK=
HuO-3N1 MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwNECwOVUh|ryP NV[5OotuW0GQR1XS
VMRC-RCZ M1zUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPFc45KSzVyPUCuOFA{ODNizszN MkTvV2FPT0WU
SW954 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnZRoVzUUN3ME2wMlQxOzN3IN88US=> NWP4emlbW0GQR1XS
MES-SA NFXQUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHlTWM2OD1yLkSwOVA2KM7:TR?= M1npe3NCVkeHUh?=
Ca-Ski MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7pOoFkUUN3ME2wMlQxPTJ2IN88US=> NVLXdIFbW0GQR1XS
SW13 M4K0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K2PWlEPTB;MD60NFYzPiEQvF2= NU\mWXNVW0GQR1XS
NCI-H1437 NXjlc3JXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX76eGlKUUN3ME2wMlQxQDB3IN88US=> NF60SppUSU6JRWK=
U-118-MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXLSYxKSzVyPUCuOFA6ODRizszN NVuwNnRTW0GQR1XS
NCI-H1734 NUK0UYdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MomwTWM2OD1yLkSyNFE{KM7:TR?= MV3TRW5ITVJ?
HDLM-2 NU\mdGt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfSOYhKSzVyPUCuOFIxOzNizszN Mk\6V2FPT0WU
AU565 M3TaOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNEK0Olgh|ryP NGO1ZXFUSU6JRWK=
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OS-RC-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjMTWM2OD1yLkSzNFg{KM7:TR?= MoGxV2FPT0WU
CAMA-1 MnTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;xTYpxUUN3ME2wMlQ{PjJ4IN88US=> M170ZnNCVkeHUh?=
MONO-MAC-6 M2HS[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0em5bUUN3ME2wMlQ{QDR7IN88US=> MonKV2FPT0WU
LB831-BLC NYr1UW5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHVWY52UUN3ME2wMlQ1OzdzIN88US=> MX;TRW5ITVJ?
SW982 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfOXFVjUUN3ME2wMlQ1PTJ6IN88US=> NFHkbZpUSU6JRWK=
SCC-3 NXPOVoVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XzXGlEPTB;MD60OFU4QSEQvF2= MnHrV2FPT0WU
C32 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjUO45KSzVyPUCuOFUzOjlizszN NH\5[IRUSU6JRWK=
BFTC-909 NXfVS2VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D2eWlEPTB;MD60OVI6QSEQvF2= NXHWZmMzW0GQR1XS
MEG-01 NHPEb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7vTWM2OD1yLkS1N|c{KM7:TR?= MVzTRW5ITVJ?
M14 NXzVT4llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;1TWM2OD1yLkS1PVc6KM7:TR?= MkLEV2FPT0WU
MPP-89 Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz4RmZKSzVyPUCuOFYzPTZizszN M{\pdnNCVkeHUh?=
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LB996-RCC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHWUGR7UUN3ME2wMlQ4ODV2IN88US=> NYDYW5dRW0GQR1XS
C8166 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jlVWlEPTB;MD60O|Qh|ryP M2TzRnNCVkeHUh?=
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TE-5 NFjXdXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT5[Ih7UUN3ME2wMlQ5OzB3IN88US=> NXnBV3cxW0GQR1XS
KYSE-520 NGO5W4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4CySWlEPTB;MD60PFM1OyEQvF2= MV7TRW5ITVJ?
Detroit562 MmTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jQRmlEPTB;MD60PFg3KM7:TR?= NYnBc4V3W0GQR1XS
SIMA NG[1VmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwNEm0NVch|ryP M3HaenNCVkeHUh?=
NCI-H1651 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLmTWM2OD1yLkS5Olch|ryP MWXTRW5ITVJ?
HCC1599 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;hTWM2OD1yLkS5PVU2KM7:TR?= Mn7GV2FPT0WU
ABC-1 NWDuPZA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT4bpRKSzVyPUCuOVA1QTZizszN MoLTV2FPT0WU
CAL-33 M3zhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkSyTWM2OD1yLkWwPFQ1KM7:TR?= MXfTRW5ITVJ?
OPM-2 M{PiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHVO4FKUUN3ME2wMlUxQTN5IN88US=> M3HvWnNCVkeHUh?=
RPMI-7951 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT2Nm5KSzVyPUCuOVA6PTdizszN MXTTRW5ITVJ?
HT-1080 MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\aTWM2OD1yLkWxNVE6KM7:TR?= NVzwTJBMW0GQR1XS
LC4-1 MmrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTHU5ZQUUN3ME2wMlUyPDB|IN88US=> M4rNfnNCVkeHUh?=
OVCAR-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH0WoJKSzVyPUCuOVE2PyEQvF2= NEHFe29USU6JRWK=
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SK-OV-3 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTBwNUK0N|Qh|ryP MYnTRW5ITVJ?
HuP-T3 NVL2PY0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEewRoRKSzVyPUCuOVI5OjdizszN MlHBV2FPT0WU
NCI-H838 NFLTfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;STWM2OD1yLkWyPFQ6KM7:TR?= M4q2W3NCVkeHUh?=
K5 NVLiRnJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLLdJhKSzVyPUCuOVMzODFizszN MWPTRW5ITVJ?
CAL-72 M4SxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwNUOzPFch|ryP MUXTRW5ITVJ?
NH-12 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDCTWM2OD1yLkWzPVU6KM7:TR?= NEHlPYRUSU6JRWK=
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NCI-H2052 NH\wS3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNU[3OFEh|ryP MmO0V2FPT0WU
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COR-L279 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3vc4JxUUN3ME2wMlU4OTh3IN88US=> MlTlV2FPT0WU
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NCI-H1703 NFPUflVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwNUm0Nlch|ryP MUfTRW5ITVJ?
UACC-257 Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrDdFVvUUN3ME2wMlU6PDh5IN88US=> NYDHWXR5W0GQR1XS
KALS-1 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HvVGlEPTB;MD62NFAyOSEQvF2= MUPTRW5ITVJ?
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ChaGo-K-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW2SHNUUUN3ME2wMlYyOjJ7IN88US=> NFPSdlBUSU6JRWK=
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RT-112 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHOTWM2OD1yLk[2OVg4KM7:TR?= M4jIOnNCVkeHUh?=
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NCI-H2170 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwNkiyOVgh|ryP NHzhT5FUSU6JRWK=
GDM-1 NG\Zc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzrTWM2OD1yLk[4OFk1KM7:TR?= MkPkV2FPT0WU
KP-4 NVP4XGVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jwVWlEPTB;MD62PVU4OyEQvF2= NXzRcXZyW0GQR1XS
VA-ES-BJ MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moe5TWM2OD1yLk[5PVg3KM7:TR?= M4[wPXNCVkeHUh?=
KM-H2 NFLHVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j0W2lEPTB;MD63NFA6OSEQvF2= NITWWGNUSU6JRWK=
HH MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXBb|FKSzVyPUCuO|A3PjJizszN NFGx[WdUSU6JRWK=
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COLO-829 NXPnfIZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PyZWlEPTB;MD63NVk5PSEQvF2= MUXTRW5ITVJ?
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NCI-H28 NHPL[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwN{SwPFMh|ryP NXLHTWdiW0GQR1XS
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LB2241-RCC NGjjflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDjOFc4UUN3ME2wMlc3ODh5IN88US=> NHW0U3pUSU6JRWK=
CCRF-CEM NVnyOo5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PNUGlEPTB;MD63O|A2OiEQvF2= Mn3UV2FPT0WU
NCI-H510A NFfhbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHs[|YzUUN3ME2wMlc4OTh4IN88US=> NXzrcoZbW0GQR1XS
SW48 NX;5TmVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzQXGdbUUN3ME2wMlc4OzN|IN88US=> MVLTRW5ITVJ?
NCI-H2081 NGDJRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmyRW5KSzVyPUCuO|gyPDdizszN NWjRNYVuW0GQR1XS
RMG-I M4HuXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIWwWFdKSzVyPUCuO|gzOTJizszN NV7CXZhOW0GQR1XS
LU-99A M1X5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmySGdKSzVyPUCuO|g1OTNizszN NHLqUmRUSU6JRWK=
KP-N-YS NWXSSXN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmf0TWM2OD1yLke4PVIyKM7:TR?= NV3Xbm5MW0GQR1XS
MDA-MB-231 NFfJclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37XNGlEPTB;MD64NFE{OSEQvF2= MVvTRW5ITVJ?
U031 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zifGlEPTB;MD64NVQzOyEQvF2= NYrmNJJzW0GQR1XS
EVSA-T M4LUWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWzV|M1UUN3ME2wMlgyPjd{IN88US=> NHOxPG9USU6JRWK=
MDA-MB-157 M4rPfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:zTWM2OD1yLkiyNlcyKM7:TR?= MoXOV2FPT0WU
EHEB NHvJc|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInYepFKSzVyPUCuPFIzPzZizszN MoD0V2FPT0WU
KINGS-1 NEThSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwOEK1OVUh|ryP NH;O[VdUSU6JRWK=
23132-87 NHm5TXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfDTWM2OD1yLkiyPFQ{KM7:TR?= MVXTRW5ITVJ?
EFO-21 MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PoWGlEPTB;MD64OFA5QSEQvF2= NETBXlZUSU6JRWK=
DOK Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;4TWM2OD1yLki0PEDPxE1? NGPURVlUSU6JRWK=
NCI-H2171 M4Lw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LFfGlEPTB;MD64OFk3KM7:TR?= NXHm[Jl1W0GQR1XS
NCI-SNU-5 NH;uUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTuV4l[UUN3ME2wMlg2PTdizszN MoH5V2FPT0WU
SK-N-DZ NV3LRlNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXj3TodJUUN3ME2wMlg2QTR|IN88US=> MYjTRW5ITVJ?
SNU-C2B MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm0Xm1rUUN3ME2wMlg3QDBzIN88US=> NXXIdVZiW0GQR1XS
CP66-MEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwOEexNUDPxE1? M4Lle3NCVkeHUh?=
SN12C NIP5SXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jOWWlEPTB;MD64PFY{PyEQvF2= NFuweYJUSU6JRWK=
A172 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO4dFdKSzVyPUCuPFg3QThizszN NIfkc|NUSU6JRWK=
NCI-H2347 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwOEi3OVMh|ryP NIPjdI9USU6JRWK=
NCI-H2228 NYfBO|JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\uVZVKSzVyPUCuPFk{OzlizszN M1PjdHNCVkeHUh?=
SNU-387 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwOUCyOlQh|ryP MVTTRW5ITVJ?
SK-MEL-24 M{XXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnNPYpKSzVyPUCuPVE{PDRizszN Mn7EV2FPT0WU
MDA-MB-468 M4HlTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwOUG3N{DPxE1? MYHTRW5ITVJ?
NCI-H1694 MmriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXmWopKSzVyPUCuPVE5PzZizszN Ml;kV2FPT0WU
CCF-STTG1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYH0eWdSUUN3ME2wMlkzPjN5IN88US=> MUDTRW5ITVJ?
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NCI-H446 NELGdGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3w[lNuUUN3ME2wMlk2ODFizszN NGXaN2dUSU6JRWK=
MFE-280 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHUWVRKSzVyPUCuPVYzQTFizszN MULTRW5ITVJ?
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Raji MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XMW2lEPTB;MT6wNlI3PyEQvF2= MnX3V2FPT0WU
TE-6 NGPRdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKzRXJDUUN3ME2xMlA{PTZ4IN88US=> MYnTRW5ITVJ?
CAL-148 M4fGUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjJeXhKSzVyPUGuNFQ1PDNizszN MXjTRW5ITVJ?
NCI-H1963 NFW5Z49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\kb2lEPTB;MT6wOFU2OyEQvF2= NHzpfYZUSU6JRWK=
SK-N-AS M4LWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\vc5hKSzVyPUGuNFQ3QDVizszN MVXTRW5ITVJ?
RERF-LC-MS M1;IWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwME[zOFkh|ryP MnfvV2FPT0WU
BEN NUTBNIh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPuTWM2OD1zLkC3NVM4KM7:TR?= MmfuV2FPT0WU
CAS-1 M3vtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvqWGNDUUN3ME2xMlA6OTJ|IN88US=> MkDUV2FPT0WU
SW780 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwMEmxPFEh|ryP NEe5UmNUSU6JRWK=
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D-283MED NYfGWmJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\YR2lEPTB;MT6xNlI4OiEQvF2= NVz0eHAxW0GQR1XS
HCC2157 NFnBVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXPTWM2OD1zLkGzOlQzKM7:TR?= MYTTRW5ITVJ?
RCC10RGB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\2OIJuUUN3ME2xMlE1ODB4IN88US=> Mm\5V2FPT0WU
PLC-PRF-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;oTWM2OD1zLkG1NlI6KM7:TR?= MXTTRW5ITVJ?
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TUR MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLoZVBiUUN3ME2xMlE2PzV{IN88US=> NYmwdnc1W0GQR1XS
NCI-H2141 M3PhPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV31d3ZIUUN3ME2xMlE5QTR4IN88US=> NFTncZpUSU6JRWK=
PFSK-1 M2XYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLtdolKSzVyPUGuNlA2OzJizszN NYDBTnNXW0GQR1XS
SK-MEL-28 NX3V[W5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\DRmh5UUN3ME2xMlI{OjJzIN88US=> MUDTRW5ITVJ?
SCC-9 M1TtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\0[mlEPTB;MT6yN|Y3PSEQvF2= NWmwRWN4W0GQR1XS
T47D NH3jXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fDfmlEPTB;MT6yN|Y6PiEQvF2= MYnTRW5ITVJ?
TCCSUP MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFwMkWwNlkh|ryP M1PMfnNCVkeHUh?=
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DMS-114 NFLYVlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn3N4ZJUUN3ME2xMlI3PjN{IN88US=> M3\tZnNCVkeHUh?=
BOKU MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTBTWM2OD1zLkK4NFk2KM7:TR?= NHv0VFhUSU6JRWK=
MS-1 NVTLfnRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\mWZdzUUN3ME2xMlI6ODZ7IN88US=> NHvQV3dUSU6JRWK=
NCI-H661 NXjDWFBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwM{C0O|gh|ryP M1TtenNCVkeHUh?=
HT-3 NIW0VYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzkOHlKSzVyPUGuN|A2OjlizszN MnGwV2FPT0WU
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SW1463 M4L0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTFwM{G4O|Ih|ryP NXi5NVBCW0GQR1XS
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PANC-08-13 MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFwM{O4NFMh|ryP MXPTRW5ITVJ?
BB49-HNC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTFwM{SwNUDPxE1? NHryUIpUSU6JRWK=
M059J MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe0[o1KSzVyPUGuN|U5OzJizszN NY\uT2pNW0GQR1XS
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no-10 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1m5NWlEPTB;MT60OlE5OSEQvF2= MVXTRW5ITVJ?
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NCI-H1304 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTFwNkO1PVEh|ryP M1HYVnNCVkeHUh?=
Becker M3PGRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrwUndnUUN3ME2xMlY1OjRzIN88US=> NXKyWIdkW0GQR1XS
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EKVX MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr2PXRSUUN3ME2xMlY2PjF6IN88US=> MkPBV2FPT0WU
KLE NUTZZlVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjLdJZlUUN3ME2xMlY2PzF2IN88US=> M2rDUXNCVkeHUh?=
K-562 Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFwNkewN|ch|ryP NWfqXIhTW0GQR1XS
MDA-MB-175-VII NHnYdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TlR2lEPTB;MT62PFk6PyEQvF2= MonVV2FPT0WU
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HCC1187 NIXrZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3PSJZTUUN3ME2xMlcxPTR3IN88US=> MXXTRW5ITVJ?
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MOLT-16 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1znVmlEPTB;MT63N|MxPyEQvF2= NYrmcnlVW0GQR1XS
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DV-90 MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3Wd2VKSzVyPUGuO|U2QDVizszN MVjTRW5ITVJ?
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MDA-MB-415 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJwMUe1NkDPxE1? MkizV2FPT0WU
NCI-H2126 M4DPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvFTWM2OD1{LkKyPFg5KM7:TR?= NUPT[FVJW0GQR1XS
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NCI-H1581 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjUTWM2OD1{LkOyNVA2KM7:TR?= M4DNUnNCVkeHUh?=
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GCT NVHBd2gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\TTWM2OD1{LkW4Olk1KM7:TR?= MXPTRW5ITVJ?
SK-CO-1 M4mwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jTVWlEPTB;Mj62NVY3KM7:TR?= MnzTV2FPT0WU
NCI-H526 NV\4R|ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED0ZolKSzVyPUKuOlM1PSEQvF2= NGXDSGVUSU6JRWK=
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NCI-H1618 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzqTWM2OD1{Lki4NVU{KM7:TR?= M2LWUHNCVkeHUh?=
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NCI-H1623 M4HxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\lTWM2OD1|LkC5N|Qh|ryP NYP3OmkyW0GQR1XS
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D-263MG MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1OyVWlEPTB;Mz6xOFc5QCEQvF2= MVnTRW5ITVJ?
NCI-H1573 M3HpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUflXXRGUUN3ME2zMlE6PjRzIN88US=> MVfTRW5ITVJ?
NCI-H82 MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fr[WlEPTB;Mz6zOFQ{QSEQvF2= NFvCfZJUSU6JRWK=
NCI-H2196 M1jxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTNwM{WwNFgh|ryP M4jGOXNCVkeHUh?=
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COLO-678 NHToUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTwTWM2OD1|LkO4NVg3KM7:TR?= NFW2VGJUSU6JRWK=
EW-3 M1;WTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jBbGlEPTB;Mz60NFk2KM7:TR?= MWrTRW5ITVJ?
MHH-NB-11 NILQOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrTem4xUUN3ME2zMlQ1ODZ7IN88US=> MVnTRW5ITVJ?
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FTC-133 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfZbYwzUUN3ME2zMlY2PDV6IN88US=> MnTlV2FPT0WU
NCI-H209 NIrhUFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37nfWlEPTB;Mz62O|Y2OyEQvF2= MVTTRW5ITVJ?
TGBC24TKB NIHIOFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH1[IxoUUN3ME2zMlY5OzV3IN88US=> NWPBWI5[W0GQR1XS
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C-4-II NGDufYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvVUmN3UUN3ME2zMlc2PjR|IN88US=> MomwV2FPT0WU
NCI-H1650 MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLZTWM2OD1|Lke4OFU2KM7:TR?= M3;CUHNCVkeHUh?=
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MDA-MB-134-VI M{WxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnFTWM2OD12LkCyPVUzKM7:TR?= M1O2d3NCVkeHUh?=
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NCI-N87 M{DXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MontTWM2OD12LkO4PFIyKM7:TR?= NXPHbng5W0GQR1XS
NB6 NHvaT3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\LTWM2OD12LkSyOVA6KM7:TR?= M3W5[3NCVkeHUh?=
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NCI-H1882 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPkfHJKSzVyPUSuOVA2PyEQvF2= NHrPRXNUSU6JRWK=
WM-115 NITPclNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PLTGlEPTB;ND61NFg5OSEQvF2= MX3TRW5ITVJ?
SKG-IIIa NHn4OY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTRwNke3O{DPxE1? M{PIZnNCVkeHUh?=
NCI-H69 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Pxd2lEPTB;ND63NFI4PSEQvF2= MnTZV2FPT0WU
MSTO-211H MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml74TWM2OD12LkizOVY2KM7:TR?= NFrmb2FUSU6JRWK=
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GI-ME-N NVThOphJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[4d2lEPTB;NT6wNFUxQSEQvF2= NUO3eIdwW0GQR1XS
T98G MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfkWZhKSzVyPUWuNFY2ODhizszN NUnZZm5KW0GQR1XS
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COLO-800 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPpTWM2OD13LkG5N|Q6KM7:TR?= MX;TRW5ITVJ?
NCI-H1755 M4DMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXafXhlUUN3ME21MlI{ODJ5IN88US=> MljBV2FPT0WU
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HCC1954 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXtTWM2OD13Lki1PVcyKM7:TR?= M{XGTXNCVkeHUh?=
NCI-H187 MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;QN|VFUUN3ME21MlkzQTh7IN88US=> MWrTRW5ITVJ?
LU-165 NWjDZZBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;JTWM2OD13Lkm5NFAzKM7:TR?= MWHTRW5ITVJ?
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NCI-H1155 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTnem9yUUN3ME22Mlk2PThzIN88US=> M3nLbHNCVkeHUh?=
EFE-184 NH\ZXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTdwM{G2PVUh|ryP NHXDe|hUSU6JRWK=
AsPC-1 NGDEbWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LXSWlEPTB;Nz60PFgxPyEQvF2= M3WwOnNCVkeHUh?=
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NCI-H524 M3vsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[4OWlEPTB;OT61PFYzQCEQvF2= NEnCXFZUSU6JRWK=
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NCI-H748 M3uxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:zeGV1UUN3ME2xNE43Ozl5IN88US=> M4fFT3NCVkeHUh?=
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... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID