Obatoclax Mesylate (GX15-070)

For research use only.

Catalog No.S1057

99 publications

Obatoclax Mesylate (GX15-070) Chemical Structure

CAS No. 803712-79-0

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Selleck's Obatoclax Mesylate (GX15-070) has been cited by 99 publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 NWPYSoVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMECwNFMyPyEQvF2= M1f6cHNCVkeHUh?=
SK-MEL-30 NIfLVVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP3emRGUUN3ME2wMlAxODN3NTFOwG0> MXfTRW5ITVJ?
NALM-6 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMECwN|U3KM7:TR?= MXHTRW5ITVJ?
KYSE-450 MoHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn6RlBOUUN3ME2wMlAxODR4OTFOwG0> NWD0bno3W0GQR1XS
BHY NHnkU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j1XWlEPTB;MD6wNFA3ODFizszN Mn3OV2FPT0WU
GR-ST M{HVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXRU|VQUUN3ME2wMlAxODZ2ODFOwG0> NY\Z[IRrW0GQR1XS
786-0 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljKTWM2OD1yLkCwNFc4PiEQvF2= NYjUdGMzW0GQR1XS
C-33-A MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlizTWM2OD1yLkCwNFg1QCEQvF2= M{PoUXNCVkeHUh?=
BHT-101 M4nKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\QTWM2OD1yLkCwNVA3KM7:TR?= Mor5V2FPT0WU
EB2 NHfWe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\rS2tqUUN3ME2wMlAxOTF6IN88US=> M{X1RnNCVkeHUh?=
G-361 M4HB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2n4SWlEPTB;MD6wNFEzPCEQvF2= MoPkV2FPT0WU
KE-37 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMECxNlgh|ryP NXfhNnVmW0GQR1XS
MHH-PREB-1 NGi3PW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jmN2lEPTB;MD6wNFE1KM7:TR?= NFPNOlZUSU6JRWK=
MCF7 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfTZ|VKSzVyPUCuNFAyPTlizszN M2TSe3NCVkeHUh?=
LOUCY MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMECxO|Uh|ryP M2nJdXNCVkeHUh?=
EW-7 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMECxO|Uh|ryP M2\VTnNCVkeHUh?=
KYSE-510 NEXObYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;OWmhJUUN3ME2wMlAxOjN|IN88US=> M3HUcnNCVkeHUh?=
SK-MEL-3 NYLPPJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXYNFB{UUN3ME2wMlAxOjZ2IN88US=> NXXiNplnW0GQR1XS
HAL-01 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMECyPVch|ryP NWradld5W0GQR1XS
HCC2998 NYXoXJBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD1yLkCwN|M2KM7:TR?= MUnTRW5ITVJ?
A375 NUDEVY9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HNNGlEPTB;MD6wNFM2KM7:TR?= M12zcnNCVkeHUh?=
MZ7-mel NXTneGROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMECzPVkh|ryP MWTTRW5ITVJ?
SH-4 NVvRZY8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTFS5l6UUN3ME2wMlAxPDF5IN88US=> MV3TRW5ITVJ?
HT-144 NIHWVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[0S2lEPTB;MD6wNFQ{KM7:TR?= M1rTWnNCVkeHUh?=
KYSE-140 NX24Wnh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEC0N|Uh|ryP NEXuXJpUSU6JRWK=
PSN1 M3TucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFeyVYlKSzVyPUCuNFA1PjdizszN MVvTRW5ITVJ?
COLO-679 NGnEOlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIP6c|hKSzVyPUCuNFA1QThizszN MkPJV2FPT0WU
SW620 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEC1NVEh|ryP Mn3pV2FPT0WU
HGC-27 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnuR5BmUUN3ME2wMlAxPTJ2IN88US=> MYjTRW5ITVJ?
IGROV-1 NV\PPFFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTz[pFRUUN3ME2wMlAxPiEQvF2= M1fRR3NCVkeHUh?=
IGR-1 NIXQW3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2xbnkzUUN3ME2wMlAxPjBzIN88US=> MUjTRW5ITVJ?
EW-1 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr3VnZbUUN3ME2wMlAxPjVzIN88US=> MWrTRW5ITVJ?
769-P M{PsbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG5TWM2OD1yLkCwOlc5KM7:TR?= MWHTRW5ITVJ?
HN NWfiTVdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PZOmlEPTB;MD6wNFY4QSEQvF2= NF74fVFUSU6JRWK=
SIG-M5 M1TFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PhPWlEPTB;MD6wNFcyKM7:TR?= NIfP[pBUSU6JRWK=
IST-MEL1 NYfIdoR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUS2SZd[UUN3ME2wMlAxQDF6IN88US=> MlixV2FPT0WU
ST486 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzsb3IzUUN3ME2wMlAxQDJ3IN88US=> NWnuTmZzW0GQR1XS
ES7 NH;yT4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEC4OFYh|ryP NFHwO2hUSU6JRWK=
GAK NEXEPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEC4OFgh|ryP Mnr5V2FPT0WU
BB30-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXWbGlKUUN3ME2wMlAxQDV6IN88US=> NIT5eHlUSU6JRWK=
IPC-298 NGPG[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEC5Nlch|ryP MYTTRW5ITVJ?
NKM-1 Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moj0TWM2OD1yLkCwPVczKM7:TR?= MlnHV2FPT0WU
RKO NHS3eJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMEGwOFQh|ryP NV3RR3oxW0GQR1XS
ACN NVro[Xd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEGxN|Eh|ryP Mn\yV2FPT0WU
SW1417 NIHHV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMEGyNlUh|ryP MYrTRW5ITVJ?
SR NVvnNYsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnoTWM2OD1yLkCxNlM2KM7:TR?= M{jCPHNCVkeHUh?=
SNG-M MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEGzNVch|ryP NYfWTm5nW0GQR1XS
CAL-12T MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnNcI1KSzVyPUCuNFE{PDZizszN MnLCV2FPT0WU
HSC-3 MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEGzOVUh|ryP MWrTRW5ITVJ?
DOHH-2 NFTOemVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEToPWNKSzVyPUCuNFE1OTJizszN NH\pTWpUSU6JRWK=
NB69 NI[5[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHwTWM2OD1yLkCxOVY2KM7:TR?= NHTicJRUSU6JRWK=
LC-2-ad M3z5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXezb3hyUUN3ME2wMlAyPThzIN88US=> NXTnfIhlW0GQR1XS
RVH-421 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMEG2O|Qh|ryP MUPTRW5ITVJ?
TGW M3;ONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMEG3N|kh|ryP M{ewOHNCVkeHUh?=
HCC1569 NWfCfXRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\hTWM2OD1yLkCxO|k4KM7:TR?= NYTvcZg1W0GQR1XS
CAL-85-1 NYXQTHU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSwTWM2OD1yLkCxPFMzKM7:TR?= MV;TRW5ITVJ?
RPMI-8402 MkjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzQdW43UUN3ME2wMlAyQDV6IN88US=> MVXTRW5ITVJ?
THP-1 NIT6TIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33FTmlEPTB;MD6wNVk6QCEQvF2= MU\TRW5ITVJ?
ONS-76 NU\ae2lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PlbmlEPTB;MD6wNlA{PiEQvF2= NHi4cVdUSU6JRWK=
A2780 M3PKb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEKwO|kh|ryP M4\nWnNCVkeHUh?=
RPMI-2650 NE\zZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTnTWM2OD1yLkCyNlk3KM7:TR?= NHHxfVZUSU6JRWK=
MEL-HO M{XRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vrXmlEPTB;MD6wNlM1QCEQvF2= NH\UUVRUSU6JRWK=
MC-CAR NUD2NY04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHkTWM2OD1yLkCyN|U3KM7:TR?= NHPDT3RUSU6JRWK=
HSC-2 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjl[mJwUUN3ME2wMlAzPDZ4IN88US=> NIPmZ|ZUSU6JRWK=
MEL-JUSO NWTnSppoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojETWM2OD1yLkCyOFc{KM7:TR?= M{TEWXNCVkeHUh?=
CAL-62 MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DVVWlEPTB;MD6wNlYxOiEQvF2= NX\nUllFW0GQR1XS
DMS-273 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEK4OFch|ryP NELqe2FUSU6JRWK=
S-117 M{f4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nFS2lEPTB;MD6wNlkxPiEQvF2= MYjTRW5ITVJ?
SUP-T1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTCXnRVUUN3ME2wMlAzQTR7IN88US=> MUTTRW5ITVJ?
MZ2-MEL NXjsblR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LRSmlEPTB;MD6wNlk2QSEQvF2= NF7pd|hUSU6JRWK=
KYSE-270 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEK5O|Yh|ryP NVz2N2xtW0GQR1XS
CMK NIfpTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEOwNlMh|ryP NU\Yc3g1W0GQR1XS
8505C NUL5To4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHiXHNKSzVyPUCuNFMxPCEQvF2= M{LSO3NCVkeHUh?=
NUGC-3 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3SwOmlEPTB;MD6wN|A1QCEQvF2= MmnBV2FPT0WU
A101D NIW5VFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml74TWM2OD1yLkCzNFU2KM7:TR?= MVTTRW5ITVJ?
G-401 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPrfoNYUUN3ME2wMlA{ODl|IN88US=> MWDTRW5ITVJ?
OVCAR-8 NYLqSYVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLMTWM2OD1yLkCzNVA4KM7:TR?= NV7Rb3NHW0GQR1XS
IMR-5 NHzKRoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH73ZWdKSzVyPUCuNFMzPDRizszN M1juPHNCVkeHUh?=
DoTc2-4510 NID1dGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml[xTWM2OD1yLkCzN|k{KM7:TR?= MWPTRW5ITVJ?
HOS MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjwTWM2OD1yLkCzOFc{KM7:TR?= MnTpV2FPT0WU
HEC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nNO2lEPTB;MD6wN|Y5KM7:TR?= MmLRV2FPT0WU
SW756 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCzR3ZKSzVyPUCuNFM5OjFizszN MUfTRW5ITVJ?
NCI-H64 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX:wW4E4UUN3ME2wMlA{QDR{IN88US=> MkTzV2FPT0WU
EW-16 NEDGN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEO5NFkh|ryP NFfIWIxUSU6JRWK=
CAL-51 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMESwNFUh|ryP NGnnVYJUSU6JRWK=
KYSE-150 NVyzN2lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmWxTWM2OD1yLkC0NFEyKM7:TR?= NFS1cW9USU6JRWK=
SW1710 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CwWWlEPTB;MD6wOFAyQCEQvF2= MVzTRW5ITVJ?
HuP-T4 NHXnRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PRc2lEPTB;MD6wOFEyQCEQvF2= NHGyRlZUSU6JRWK=
LB373-MEL-D MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTmbZI1UUN3ME2wMlA1OjN{IN88US=> MV\TRW5ITVJ?
EW-13 M2KwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLNTWM2OD1yLkC0OFA3KM7:TR?= MnrTV2FPT0WU
HT-29 M3rCUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH76XVFKSzVyPUCuNFQ1QSEQvF2= NWLWNWltW0GQR1XS
SCC-25 M1rVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHF[GlKSzVyPUCuNFQ1QTRizszN MV7TRW5ITVJ?
REH NVX6bFdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzve3VtUUN3ME2wMlA1PjN3IN88US=> MVvTRW5ITVJ?
L-363 NIO4bmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLDRYdKSzVyPUCuNFQ3PzlizszN NVLqc4lRW0GQR1XS
NCI-H1770 MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvXTWM2OD1yLkC0Olk4KM7:TR?= M4rIdXNCVkeHUh?=
CHL-1 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnTRYhCUUN3ME2wMlA1QDV5IN88US=> NV\iU3UzW0GQR1XS
ES1 M3nlPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fa[mlEPTB;MD6wOFg5PSEQvF2= MlHWV2FPT0WU
SCC-15 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;UW49YUUN3ME2wMlA1QTB{IN88US=> MYLTRW5ITVJ?
MRK-nu-1 NInxZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHTSWRKSzVyPUCuNFQ6OzZizszN NUHq[lNTW0GQR1XS
PF-382 NHPGflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTlTI1XUUN3ME2wMlA1QTN7IN88US=> M2HhfHNCVkeHUh?=
COLO-680N NED5cXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLDbZZKSzVyPUCuNFUxPDdizszN MlW3V2FPT0WU
LK-2 MojpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LQU2lEPTB;MD6wOVA3OyEQvF2= MlzGV2FPT0WU
NCI-H2342 NGL0eGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETsT4ZKSzVyPUCuNFUyOTdizszN Mlj3V2FPT0WU
HMV-II NUDzeIkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;BR5lKSzVyPUCuNFUzOzlizszN NUixcYJzW0GQR1XS
PC-14 M{LyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoqxTWM2OD1yLkC1NlUzKM7:TR?= NFixUJVUSU6JRWK=
COLO-320-HSR NYTydW5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMEWyPFkh|ryP M4LadHNCVkeHUh?=
697 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIL6blZKSzVyPUCuNFU{OjNizszN MXrTRW5ITVJ?
NEC8 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXPWGZUUUN3ME2wMlA2PTlizszN M{LmZXNCVkeHUh?=
LCLC-97TM1 M3LnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH4TWM2OD1yLkC1OVk1KM7:TR?= NFvRWJlUSU6JRWK=
Daoy MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwMEW2NVYh|ryP MmDJV2FPT0WU
ETK-1 MmjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImyW4ZKSzVyPUCuNFU3PzJizszN MnPWV2FPT0WU
A388 M4XjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHXc4FuUUN3ME2wMlA2Pjl3IN88US=> NYfmZ48xW0GQR1XS
COLO-205 M2jwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMEW3NVYh|ryP M{TNNHNCVkeHUh?=
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EB-3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPHO|VKSzVyPUCuNVc{OSEQvF2= NUfGPYpIW0GQR1XS
HCC1143 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPUSGR{UUN3ME2wMlE4Ozl4IN88US=> NHzk[IFUSU6JRWK=
DJM-1 M{fadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf4UHdKSzVyPUCuNVc1PTFizszN NXrpRms4W0GQR1XS
BT-474 NVzqOm1bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLoTWM2OD1yLkG3OFg6KM7:TR?= NHPNemtUSU6JRWK=
BB65-RCC NVz1SnFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMUe1OFUh|ryP MnfSV2FPT0WU
NCI-H292 NXfU[WNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC1TWM2OD1yLkG3OlAyKM7:TR?= NV;DTINyW0GQR1XS
MKN28 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XROmlEPTB;MD6xO|Y2OyEQvF2= MV7TRW5ITVJ?
TK10 Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTlVm9pUUN3ME2wMlE4PzB{IN88US=> NWLqSYd3W0GQR1XS
TYK-nu NHTDflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMUe5OFkh|ryP MlW1V2FPT0WU
8305C MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKzZpd7UUN3ME2wMlE4QTdzIN88US=> MX\TRW5ITVJ?
MV-4-11 Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHWXFlKSzVyPUCuNVc6PzdizszN NVHxWVAxW0GQR1XS
NCI-H522 MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37mO2lEPTB;MD6xPFA6PCEQvF2= NGCyU4JUSU6JRWK=
Hs-578-T M2TSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7OXllSUUN3ME2wMlE5Ojl{IN88US=> Ml7EV2FPT0WU
LCLC-103H NF6yS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMUi1Nlch|ryP MnXOV2FPT0WU
MHH-ES-1 NXPHNIc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMUi2Nlkh|ryP Ml3QV2FPT0WU
NCI-H441 M3\pbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{T4d2lEPTB;MD6xPVE1QCEQvF2= NYr5Wm1YW0GQR1XS
AM-38 M4jBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPTSWdbUUN3ME2wMlE6OjJ3IN88US=> NGTWR5dUSU6JRWK=
SW1783 NIrhZlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTBwMUmzNFUh|ryP MkPIV2FPT0WU
SK-HEP-1 NHzycIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TVeWlEPTB;MD6xPVY{PyEQvF2= NELK[o5USU6JRWK=
OAW-28 NUfFVo5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfJeFJKSzVyPUCuNlAyPzhizszN M3y1fXNCVkeHUh?=
TE-15 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW4WFJsUUN3ME2wMlIxOjV{IN88US=> MknBV2FPT0WU
HCE-4 M1XzSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLjTWM2OD1yLkKwNlg1KM7:TR?= NEDlRodUSU6JRWK=
JiyoyeP-2003 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n1WGlEPTB;MD6yNFM{PiEQvF2= M{fNWnNCVkeHUh?=
OVCAR-4 NGLSPY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL6[YhSUUN3ME2wMlIxPjJ6IN88US=> Ml\nV2FPT0WU
SNU-449 M3q0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn2zTWM2OD1yLkKwO|k4KM7:TR?= NYDCNHE3W0GQR1XS
SBC-5 MorrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkGyNVUh|ryP NFSyN|NUSU6JRWK=
T84 M2\hPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMkGyOFgh|ryP NHexNXZUSU6JRWK=
LP-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;0N2lEPTB;MD6yNVMxOiEQvF2= MoXUV2FPT0WU
MG-63 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLOTWM2OD1yLkKxN|gzKM7:TR?= M4\Fc3NCVkeHUh?=
OAW-42 NXH0VG9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOzfIs2UUN3ME2wMlIyPDd6IN88US=> MVrTRW5ITVJ?
L-540 NUHnWopDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnQTWM2OD1yLkKxOVk5KM7:TR?= MXLTRW5ITVJ?
RH-1 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvETGxuUUN3ME2wMlIzOjR{IN88US=> NYXXVG9JW0GQR1XS
HCT-15 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfWTWM2OD1yLkKyOFg1KM7:TR?= MnruV2FPT0WU
OCUB-M NHS4eXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVm5WW42UUN3ME2wMlIzPDh6IN88US=> MkLhV2FPT0WU
GP5d MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i2XmlEPTB;MD6yNlUzQCEQvF2= M3;te3NCVkeHUh?=
NCI-H2030 NVfF[YJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrIS5dZUUN3ME2wMlIzPzN2IN88US=> NIH0RYlUSU6JRWK=
ML-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj4UG9DUUN3ME2wMlIzQDh7IN88US=> MYrTRW5ITVJ?
CAL-39 NUW0N283T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm4XVNKSzVyPUCuNlI6OzZizszN NELCWlNUSU6JRWK=
MIA-PaCa-2 NULKW21KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGKzS5BKSzVyPUCuNlMzQDdizszN NWjK[FM4W0GQR1XS
TE-9 NV\QO5FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWzTWM2OD1yLkKzN|Ih|ryP Mn21V2FPT0WU
LB2518-MEL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnaeWJnUUN3ME2wMlI{Ozd{IN88US=> MUPTRW5ITVJ?
DB NYrLTWhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkewTWM2OD1yLkKzOFM5KM7:TR?= MWjTRW5ITVJ?
NCI-H596 NYLqV|ZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK3TWM2OD1yLkKzOVcyKM7:TR?= MUjTRW5ITVJ?
SW1990 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fKb2lEPTB;MD6yN|k1PiEQvF2= MoPwV2FPT0WU
P30-OHK NVntbWZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMkSwOUDPxE1? M3n6RXNCVkeHUh?=
ALL-PO NFLhWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[0TWM2OD1yLkK0NVY6KM7:TR?= NYi0dW5TW0GQR1XS
Saos-2 MonIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkS1O|Eh|ryP NWq1bIFTW0GQR1XS
MFH-ino NITYUnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID4eGJKSzVyPUCuNlQ3QTJizszN MUXTRW5ITVJ?
OE33 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XFc2lEPTB;MD6yOVEyKM7:TR?= NICwZ|ZUSU6JRWK=
Calu-3 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTRendKSzVyPUCuNlUzQTdizszN M3rjO3NCVkeHUh?=
HT MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2GwT2lEPTB;MD6yOVYzOSEQvF2= M1PlU3NCVkeHUh?=
LXF-289 MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMkW5PFQh|ryP MlzlV2FPT0WU
KGN M1n4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3JTWM2OD1yLkK2NFg6KM7:TR?= MVrTRW5ITVJ?
NCI-H1417 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMk[1NlQh|ryP M4DUWnNCVkeHUh?=
SF126 M4P4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{izemlEPTB;MD6yO|MxOiEQvF2= NXnQUZh7W0GQR1XS
SAS MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH0TWM2OD1yLkK3N|A5KM7:TR?= MV\TRW5ITVJ?
22RV1 NHi2dHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMkezO|gh|ryP M1zNdnNCVkeHUh?=
GI-1 NHjONo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\heIVKSzVyPUCuNlc1QDdizszN NU\3WYEzW0GQR1XS
ES3 NGS3OVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMke3OlMh|ryP M3jZdXNCVkeHUh?=
NB1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{CyZWlEPTB;MD6yO|g4PiEQvF2= MXzTRW5ITVJ?
NCI-H650 NWPuTZN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLWTWM2OD1yLkK4N|AzKM7:TR?= MXzTRW5ITVJ?
IST-MES1 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonTTWM2OD1yLkK4OVU1KM7:TR?= NYT4WItlW0GQR1XS
UM-UC-3 NGHIfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPpTJZKSzVyPUCuNlkyPCEQvF2= NUj3UlhyW0GQR1XS
CAL-120 M4HWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jNWGlEPTB;MD6yPVY{OSEQvF2= M{TJU3NCVkeHUh?=
UACC-62 NETre5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwM{CyOFEh|ryP NYLtfZlnW0GQR1XS
TE-11 NXzhTYo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzmTXdKSzVyPUCuN|AzPDlizszN M{fSSHNCVkeHUh?=
MKN1 MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoWzTWM2OD1yLkOwN|Yh|ryP NWTFRZpSW0GQR1XS
KS-1 NXHTfFA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwM{C1NlYh|ryP MVXTRW5ITVJ?
GCIY NYrTcGZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7jTWM2OD1yLkOxNFAzKM7:TR?= MVrTRW5ITVJ?
OVCAR-5 NFfDT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXqboZKSzVyPUCuN|EyODZizszN NYHWW21GW0GQR1XS
U-266 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;OdphRUUN3ME2wMlMyOTR5IN88US=> M4rEN3NCVkeHUh?=
Calu-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDGbWxKSzVyPUCuN|EzQDlizszN MYfTRW5ITVJ?
SK-LMS-1 MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwM{G0Nlkh|ryP MmjFV2FPT0WU
COLO-741 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TrVWlEPTB;MD6zNVYyPCEQvF2= NWnMfWkyW0GQR1XS
RPMI-8226 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\iR2lEPTB;MD6zNVY1OSEQvF2= NXjONWg4W0GQR1XS
KM12 NGHPZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwM{G4N{DPxE1? MYDTRW5ITVJ?
NMC-G1 NHH3O49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPXXZZKSzVyPUCuN|E5PiEQvF2= NFrBNpVUSU6JRWK=
SJRH30 NULLV|RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwM{KwOVIh|ryP M3u5SXNCVkeHUh?=
COR-L105 NG[zT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWftT2VJUUN3ME2wMlMzOjF6IN88US=> MYLTRW5ITVJ?
IM-9 M2LSRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37GfGlEPTB;MD6zN|AzOSEQvF2= M4nubnNCVkeHUh?=
TE-12 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{H5Z2lEPTB;MD6zN|MyPyEQvF2= MYrTRW5ITVJ?
KG-1 Mne0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzvTWM2OD1yLkOzOFMzKM7:TR?= Mmm3V2FPT0WU
U251 M3fFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwM{O0OVYh|ryP NFTpTVZUSU6JRWK=
EFO-27 NUjTdFFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XXTWlEPTB;MD6zN|k2OSEQvF2= NYXzZ3FkW0GQR1XS
EW-24 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrhcXZnUUN3ME2wMlM{QTh2IN88US=> NEnUdoVUSU6JRWK=
SF295 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLWTWM2OD1yLkOzPVk6KM7:TR?= M2XHW3NCVkeHUh?=
MC-IXC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfTTWM2OD1yLkO0OUDPxE1? MU\TRW5ITVJ?
NCI-H2405 M{i1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XvWmlEPTB;MD6zOFc{OiEQvF2= NUDCb|F[W0GQR1XS
NCI-H2009 M2\hT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\TW2lEPTB;MD6zOFc{QSEQvF2= M13UU3NCVkeHUh?=
LB1047-RCC NVP1TFloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHraXHVKSzVyPUCuN|U5OTVizszN MlHDV2FPT0WU
KNS-81-FD MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK2Vpl[UUN3ME2wMlM3PjZ5IN88US=> M1XMZnNCVkeHUh?=
HOP-92 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnH[XExUUN3ME2wMlM3QDNizszN MkTXV2FPT0WU
L-428 M1TnbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jtfmlEPTB;MD6zO|AyPiEQvF2= NYrifoxMW0GQR1XS
C3A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET2d41KSzVyPUCuN|c{PzlizszN NGTwNY1USU6JRWK=
NCI-H1792 M2TufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwM{e2OVUh|ryP NFfoT2ZUSU6JRWK=
HuH-7 NXjIdoVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEntfG1KSzVyPUCuN|c6OSEQvF2= M13k[HNCVkeHUh?=
AGS NXHubGF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwM{i2N|gh|ryP M4LrTHNCVkeHUh?=
HT-1197 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnJPVZKSzVyPUCuN|k1PiEQvF2= MYDTRW5ITVJ?
CGTH-W-1 NVXvXnpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HTT2lEPTB;MD6zPVkyOyEQvF2= NWW3fHhsW0GQR1XS
KNS-42 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\rOGM{UUN3ME2wMlQxODR3IN88US=> NH63NlZUSU6JRWK=
HuO-3N1 M{\4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwNECwOVUh|ryP NI\ZeIRUSU6JRWK=
VMRC-RCZ NFW4eldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D6dmlEPTB;MD60NFMxOyEQvF2= M1;ZdnNCVkeHUh?=
SW954 M3nxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\MdmNKSzVyPUCuOFA{OzVizszN M{DSN3NCVkeHUh?=
MES-SA MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLaUHB[UUN3ME2wMlQxPTB3IN88US=> MYXTRW5ITVJ?
Ca-Ski MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLVd41KSzVyPUCuOFA2OjRizszN MlTXV2FPT0WU
SW13 NFrzN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNEC2NlYh|ryP NITxZZJUSU6JRWK=
NCI-H1437 NVLsOZZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmmzTWM2OD1yLkSwPFA2KM7:TR?= NUTNelByW0GQR1XS
U-118-MG MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT2TWM2OD1yLkSwPVA1KM7:TR?= NVTGVFh6W0GQR1XS
NCI-H1734 NEPNe3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjkcVFlUUN3ME2wMlQzODF|IN88US=> NE\sTXJUSU6JRWK=
HDLM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPuXVVmUUN3ME2wMlQzODN|IN88US=> NX;qSYxsW0GQR1XS
AU565 NEL2N2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XhbWlEPTB;MD60NlQ3QCEQvF2= M4D4OHNCVkeHUh?=
FADU MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;6TWM2OD1yLkSyOlQ6KM7:TR?= MVjTRW5ITVJ?
OS-RC-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLWTWM2OD1yLkSzNFg{KM7:TR?= NH\MUWpUSU6JRWK=
CAMA-1 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH6TWM2OD1yLkSzOlI3KM7:TR?= MYrTRW5ITVJ?
MONO-MAC-6 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XPS2lEPTB;MD60N|g1QSEQvF2= M4LaXXNCVkeHUh?=
LB831-BLC M4raWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwNESzO|Eh|ryP Mnz1V2FPT0WU
SW982 NE\JdXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNES1Nlgh|ryP M3vo[HNCVkeHUh?=
SCC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzKTWM2OD1yLkS0OVc6KM7:TR?= NH3OVJFUSU6JRWK=
C32 NH3QbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe5b5pbUUN3ME2wMlQ2OjJ7IN88US=> MYrTRW5ITVJ?
BFTC-909 NVq2S4ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\IZmlEPTB;MD60OVI6QSEQvF2= Mn;jV2FPT0WU
MEG-01 NWDDVHpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnSPWNKUUN3ME2wMlQ2Ozd|IN88US=> MWTTRW5ITVJ?
M14 NUnG[YhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNEW5O|kh|ryP NUPyT5V6W0GQR1XS
MPP-89 NV:yNZJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjpTWM2OD1yLkS2NlU3KM7:TR?= NETHV5BUSU6JRWK=
HCC1937 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPsNZF[UUN3ME2wMlQ3Ozh2IN88US=> NFPWRnBUSU6JRWK=
SW837 M1jLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnCR3VKSzVyPUCuOFY4OjJizszN M3;2bnNCVkeHUh?=
DU-145 M4i5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzU[oZKSzVyPUCuOFY4OjlizszN NEHjTFNUSU6JRWK=
LB996-RCC NFHrTFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNEewOVQh|ryP MYLTRW5ITVJ?
C8166 NGXwO2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNEe0JO69VQ>? Mn32V2FPT0WU
MOLT-4 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjmPWpKSzVyPUCuOFc4OzRizszN Mm\BV2FPT0WU
DMS-53 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwNEe4NFkh|ryP NFHJZ5ZUSU6JRWK=
TE-5 NWGxdFZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTYTWM2OD1yLkS4N|A2KM7:TR?= MlHMV2FPT0WU
KYSE-520 M1vQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLoTWM2OD1yLkS4N|Q{KM7:TR?= NHzpV2lUSU6JRWK=
Detroit562 MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TCUmlEPTB;MD60PFg3KM7:TR?= MYrTRW5ITVJ?
SIMA NHXkcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwNEm0NVch|ryP NF\hbWNUSU6JRWK=
NCI-H1651 NWjp[m1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TFbGlEPTB;MD60PVY4KM7:TR?= NHm1NG9USU6JRWK=
HCC1599 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX4TWM2OD1yLkS5PVU2KM7:TR?= MoriV2FPT0WU
ABC-1 NWDoSJBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\kW2d[UUN3ME2wMlUxPDl4IN88US=> MWXTRW5ITVJ?
CAL-33 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwNUC4OFQh|ryP NXjXTo9UW0GQR1XS
OPM-2 M1G0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzUVo9PUUN3ME2wMlUxQTN5IN88US=> M4\SNXNCVkeHUh?=
RPMI-7951 NXHOXYRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrKRmhQUUN3ME2wMlUxQTV5IN88US=> MYfTRW5ITVJ?
HT-1080 NYi4Rnp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDqTWM2OD1yLkWxNVE6KM7:TR?= NWrJTWhPW0GQR1XS
LC4-1 NXrWe3NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLHSVE2UUN3ME2wMlUyPDB|IN88US=> M{\TU3NCVkeHUh?=
OVCAR-3 M1KwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNUG1O{DPxE1? NUPKOmJEW0GQR1XS
CAPAN-1 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XOXWlEPTB;MD61NlI5QCEQvF2= NVnPXHp7W0GQR1XS
SK-OV-3 NYPs[VU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;DR21HUUN3ME2wMlUzPDN2IN88US=> M2f2N3NCVkeHUh?=
HuP-T3 NXXsPJJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DjU2lEPTB;MD61NlgzPyEQvF2= NIDyNmlUSU6JRWK=
NCI-H838 NEC0RZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwNUK4OFkh|ryP MlPmV2FPT0WU
K5 M{[zWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\JTWM2OD1yLkWzNlAyKM7:TR?= NUmwNmtTW0GQR1XS
CAL-72 M1PRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LJSWlEPTB;MD61N|M5PyEQvF2= NHPmO5VUSU6JRWK=
NH-12 M3;DNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwNUO5OVkh|ryP MXLTRW5ITVJ?
SNB75 NELFS5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULsOFN4UUN3ME2wMlU2PzNizszN NIPvc3dUSU6JRWK=
BPH-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwNU[zOFQh|ryP MUfTRW5ITVJ?
NOMO-1 NVXCd5RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknrTWM2OD1yLkW2N|czKM7:TR?= MlPaV2FPT0WU
G-402 NUL3RpRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mki3TWM2OD1yLkW2OFk6KM7:TR?= MXLTRW5ITVJ?
NCI-H2052 MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mme1TWM2OD1yLkW2O|QyKM7:TR?= M4f1cHNCVkeHUh?=
RCM-1 NVzNUGtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoftTWM2OD1yLkW3NVY3KM7:TR?= NYrVfXdbW0GQR1XS
COR-L279 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XMb2lEPTB;MD61O|E5PSEQvF2= MoS3V2FPT0WU
A253 MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Ps[WlEPTB;MD61O|UzPSEQvF2= Mnu0V2FPT0WU
SK-MM-2 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TTT2lEPTB;MD61O|Y4QSEQvF2= NXPOeY82W0GQR1XS
NCI-H1703 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPGTWM2OD1yLkW5OFI4KM7:TR?= MYnTRW5ITVJ?
UACC-257 NFrOSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLUTWM2OD1yLkW5OFg4KM7:TR?= M4HaNnNCVkeHUh?=
KALS-1 NH7Ne3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\2bpFXUUN3ME2wMlYxODFzIN88US=> NETkd5pUSU6JRWK=
ES5 MnzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLSZm5uUUN3ME2wMlYxPDhizszN NGTJ[4lUSU6JRWK=
MHH-CALL-2 M1zCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP3TWM2OD1yLk[wPFg5KM7:TR?= NYjGfFl3W0GQR1XS
ChaGo-K-1 M4D4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXDPVZKSzVyPUCuOlEzOjlizszN NX;mRoRIW0GQR1XS
TGBC1TKB NIfTd21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnMd41KSzVyPUCuOlE6QCEQvF2= M3TzRXNCVkeHUh?=
KU-19-19 M4faTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjEfmUzUUN3ME2wMlY1PTh4IN88US=> M2OyWXNCVkeHUh?=
COLO-684 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrnXo1KSzVyPUCuOlU3OTFizszN MkXMV2FPT0WU
LS-1034 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjLTWM2OD1yLk[1PFE6KM7:TR?= NGXxVndUSU6JRWK=
RT-112 NWnncIN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTSTWM2OD1yLk[2OVg4KM7:TR?= Mlr1V2FPT0WU
Capan-2 NEjkcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHnfG9WUUN3ME2wMlY3PjJ{IN88US=> NXXwZldvW0GQR1XS
HSC-4 NXrkcY9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;WPGlEPTB;MD62OlY6QCEQvF2= NWnrUZJuW0GQR1XS
COLO-824 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jB[GlEPTB;MD62O|gzOyEQvF2= NUjuS3lMW0GQR1XS
NCI-H2170 NFnQNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ruPGlEPTB;MD62PFI2QCEQvF2= MVPTRW5ITVJ?
GDM-1 NUDrR4VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULjTXo4UUN3ME2wMlY5PDl2IN88US=> M1Pwb3NCVkeHUh?=
KP-4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\QTWM2OD1yLk[5OVc{KM7:TR?= MVPTRW5ITVJ?
VA-ES-BJ MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPJTWM2OD1yLk[5PVg3KM7:TR?= MnroV2FPT0WU
KM-H2 NFHhWWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwN{CwPVEh|ryP NY\0dll1W0GQR1XS
HH MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDJVo5KSzVyPUCuO|A3PjJizszN MlTnV2FPT0WU
DK-MG NWH2Zpc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Xr[mlEPTB;MD63NVAyPiEQvF2= NXPGZVJCW0GQR1XS
VM-CUB-1 M2rON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmmwTWM2OD1yLkexNlU6KM7:TR?= MXHTRW5ITVJ?
COLO-829 M2fLVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPGTWM2OD1yLkexPVg2KM7:TR?= MVTTRW5ITVJ?
OMC-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjieGJZUUN3ME2wMlczOTB2IN88US=> NXn5U5VEW0GQR1XS
NB12 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXndHJKSzVyPUCuO|I2ODRizszN MW\TRW5ITVJ?
NCI-H28 M3\yVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\xNJAxUUN3ME2wMlc1ODh|IN88US=> M1\FUHNCVkeHUh?=
A673 NXj3Xm9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y4WGlEPTB;MD63OVE4PyEQvF2= NEe0PIhUSU6JRWK=
LB2241-RCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGric4ZKSzVyPUCuO|YxQDdizszN NFW1cmJUSU6JRWK=
CCRF-CEM MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnPT3JuUUN3ME2wMlc4ODV{IN88US=> MVrTRW5ITVJ?
NCI-H510A MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlexTWM2OD1yLke3NVg3KM7:TR?= MVzTRW5ITVJ?
SW48 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe4eVJKSzVyPUCuO|c{OzNizszN MYLTRW5ITVJ?
NCI-H2081 M{e4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnuNpZKSzVyPUCuO|gyPDdizszN M4rEW3NCVkeHUh?=
RMG-I M2fFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LKXGlEPTB;MD63PFIyOiEQvF2= MlTiV2FPT0WU
LU-99A NWrL[llxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LzOmlEPTB;MD63PFQyOyEQvF2= NVLhd5ZvW0GQR1XS
KP-N-YS MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\oeYNvUUN3ME2wMlc5QTJzIN88US=> NX3ocmVWW0GQR1XS
MDA-MB-231 M4H2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\JfJd6UUN3ME2wMlgxOTNzIN88US=> NHLm[JpUSU6JRWK=
U031 M1vIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\ITWM2OD1yLkixOFI{KM7:TR?= MojaV2FPT0WU
EVSA-T NULqV5RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLrOlNKSzVyPUCuPFE3PzJizszN MW\TRW5ITVJ?
MDA-MB-157 NVzkcnpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj6dFdKSzVyPUCuPFIzPzFizszN MWjTRW5ITVJ?
EHEB NH;WN4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHoO|h2UUN3ME2wMlgzOjd4IN88US=> NGq1Z|RUSU6JRWK=
KINGS-1 MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzyTWM2OD1yLkiyOVU2KM7:TR?= M{jab3NCVkeHUh?=
23132-87 NXLNZZZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HkXGlEPTB;MD64Nlg1OyEQvF2= MorMV2FPT0WU
EFO-21 MlXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HIdGlEPTB;MD64OFA5QSEQvF2= MmT4V2FPT0WU
DOK Mn7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk[2TWM2OD1yLki0PEDPxE1? MV;TRW5ITVJ?
NCI-H2171 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP3fFRpUUN3ME2wMlg1QTZizszN M4PGdnNCVkeHUh?=
NCI-SNU-5 M1\6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\KO|lLUUN3ME2wMlg2PTdizszN NYe4V2d6W0GQR1XS
SK-N-DZ NYLGSJRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwOEW5OFMh|ryP NGjH[mVUSU6JRWK=
SNU-C2B NE\Cd2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnIXHlnUUN3ME2wMlg3QDBzIN88US=> M1zacHNCVkeHUh?=
CP66-MEL NYTLXZl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXZTWM2OD1yLki3NVEh|ryP M2Cz[3NCVkeHUh?=
SN12C NGHJSJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvETWM2OD1yLki4OlM4KM7:TR?= MWDTRW5ITVJ?
A172 M3;6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwOEi2PVgh|ryP MWrTRW5ITVJ?
NCI-H2347 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17UcGlEPTB;MD64PFc2OyEQvF2= MmjoV2FPT0WU
NCI-H2228 NW\pbVZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLpWGI6UUN3ME2wMlg6OzN7IN88US=> NFXuVpVUSU6JRWK=
SNU-387 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XwV2lEPTB;MD65NFI3PCEQvF2= NGPrTXlUSU6JRWK=
SK-MEL-24 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXiTWM2OD1yLkmxN|Q1KM7:TR?= MYrTRW5ITVJ?
MDA-MB-468 NWOzWVJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;6NmlEPTB;MD65NVc{KM7:TR?= NXvBNWN6W0GQR1XS
NCI-H1694 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f4[WlEPTB;MD65NVg4PiEQvF2= M3fDbHNCVkeHUh?=
CCF-STTG1 M2X3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;rcYJ2UUN3ME2wMlkzPjN5IN88US=> M{DvN3NCVkeHUh?=
K052 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlryTWM2OD1yLkm0NFQ4KM7:TR?= NGDDTWFUSU6JRWK=
NCI-H446 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwOUWwNUDPxE1? NFz4RolUSU6JRWK=
MFE-280 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XDRWlEPTB;MD65OlI6OSEQvF2= NHnEfmpUSU6JRWK=
KU812 NWDuSpFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LSUWlEPTB;MD65PVM5QSEQvF2= M4fHbnNCVkeHUh?=
MDA-MB-361 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jUemlEPTB;MD65PVc4PyEQvF2= Ml7nV2FPT0WU
Raji M1\SNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFwMEKyOlch|ryP NXvteYY3W0GQR1XS
TE-6 NV7xemRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFwMEO1OlYh|ryP MULTRW5ITVJ?
CAL-148 M{PZW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTFwMES0OFMh|ryP MU\TRW5ITVJ?
NCI-H1963 NXzZdZJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwMES1OVMh|ryP MULTRW5ITVJ?
SK-N-AS M4PxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvaeIVIUUN3ME2xMlA1Pjh3IN88US=> MnrBV2FPT0WU
RERF-LC-MS MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTvTWM2OD1zLkC2N|Q6KM7:TR?= MlnrV2FPT0WU
BEN NWnSXm41T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwMEexN|ch|ryP NH\LSolUSU6JRWK=
CAS-1 NELLeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfofo5KSzVyPUGuNFkyOjNizszN NVzU[pd4W0GQR1XS
SW780 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDkcnZKSzVyPUGuNFkyQDFizszN MU\TRW5ITVJ?
LU-65 NVGzUY5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwMEm0NUDPxE1? MnTHV2FPT0WU
D-283MED M13mUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfaSYJsUUN3ME2xMlEzOjd{IN88US=> Mmi1V2FPT0WU
HCC2157 MmryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HJS2lEPTB;MT6xN|Y1OiEQvF2= MlTPV2FPT0WU
RCC10RGB NYTNR3hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\KfWRNUUN3ME2xMlE1ODB4IN88US=> MWPTRW5ITVJ?
PLC-PRF-5 NFrSNWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonCTWM2OD1zLkG1NlI6KM7:TR?= M1rMfnNCVkeHUh?=
H4 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X2cGlEPTB;MT6xOVQ{QSEQvF2= M13He3NCVkeHUh?=
TUR NGH3SGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHlTWM2OD1zLkG1O|UzKM7:TR?= MVHTRW5ITVJ?
NCI-H2141 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[3eXdKSzVyPUGuNVg6PDZizszN MXLTRW5ITVJ?
PFSK-1 NIjVfm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[0ZnpYUUN3ME2xMlIxPTN{IN88US=> Mn3BV2FPT0WU
SK-MEL-28 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULhO29zUUN3ME2xMlI{OjJzIN88US=> NEPtSlZUSU6JRWK=
SCC-9 NGTQfJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfwTWM2OD1zLkKzOlY2KM7:TR?= MWrTRW5ITVJ?
T47D M3yw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTFwMkO2PVYh|ryP NGHPUnFUSU6JRWK=
TCCSUP NEPEVmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDOTWM2OD1zLkK1NFI6KM7:TR?= NV7WW3R{W0GQR1XS
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HCC1954 NH7DR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTVwOEW5O|Eh|ryP MUPTRW5ITVJ?
NCI-H187 NH;HXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TGU2lEPTB;NT65Nlk5QSEQvF2= NUPlUFl2W0GQR1XS
LU-165 M{TCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnLN4k5UUN3ME21Mlk6ODB{IN88US=> NEXDSXlUSU6JRWK=
YAPC M{jPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTVwOUmwOlgh|ryP MoLwV2FPT0WU
LU-139 M3jkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTiW3lbUUN3ME22MlA5OzZ6IN88US=> MWTTRW5ITVJ?
D-502MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TSZ2lEPTB;Nj6zNlA1PyEQvF2= NUDG[3NjW0GQR1XS
IST-SL1 NYjH[GpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj5UYFpUUN3ME22MlU{QTR6IN88US=> MmHOV2FPT0WU
DG-75 M37zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTZwOEi3PFYh|ryP NEXPU4hUSU6JRWK=
NCI-H1155 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTZwOUW1PFEh|ryP Ml;2V2FPT0WU
EFE-184 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3XTWM2OD15LkOxOlk2KM7:TR?= NGPHfFJUSU6JRWK=
AsPC-1 NH30N3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhWGJKSzVyPUeuOFg5ODdizszN NYH4dmN5W0GQR1XS
SW948 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjxXFVKSzVyPUeuOVg{QTVizszN NIjScmZUSU6JRWK=
NCI-H524 Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXX[YZKSzVyPUmuOVg3OjhizszN MnTZV2FPT0WU
KOSC-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3XTWM2OD17Lk[yPFM1KM7:TR?= NX;NZoZiW0GQR1XS
T-24 M4L4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\Ud|dKSzVyPUmuPVQ1OTVizszN NULvdYI6W0GQR1XS
NCI-H748 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPBc2FKSzVyPUGwMlY{QTdizszN Mo\XV2FPT0WU
NCI-H23 NHjvPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nGVWlEPTB;MUCuOlQ1OiEQvF2= MVLTRW5ITVJ?
UACC-812 NFuxdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi4eowyUUN3ME2xNU44OTdizszN MlnoV2FPT0WU
SCLC-21H NWHnWZJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XpSGlEPTB;MUKuNVU2OSEQvF2= Mm\FV2FPT0WU
NCI-SNU-16 NEPrflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLWb3BKSzVyPUGzMlEzPThizszN NHKwfHJUSU6JRWK=
HD-MY-Z MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF2Lk[zOlMh|ryP M2LRfHNCVkeHUh?=
SK-N-FI NXzPdYNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq3UZpXUUN3ME2xOE45QTF{IN88US=> NVm4[Gs3W0GQR1XS
LB647-SCLC NWO3XVVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorVTWM2OD1zNT63NVk2KM7:TR?= NX74cmZTW0GQR1XS
NCI-H345 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjmO5ZKSzVyPUG3MlM1OyEQvF2= NYPlS3NOW0GQR1XS
NCI-H1563 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF6Lke2NFEh|ryP MUXTRW5ITVJ?
RL MoGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJzLkK2OVYh|ryP M2TEcnNCVkeHUh?=
KY821 NFzC[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ{LkC1OVMh|ryP NIDXZm5USU6JRWK=
JVM-3 NEG3XVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvtWXdrUUN3ME2yOU4xPDF|IN88US=> MUDTRW5ITVJ?
NCI-H1793 NGXrfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ6LkW0PVkh|ryP NX7VN3BYW0GQR1XS
LU-134-A NGqzb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7zSY9KSzVyPUOwMlIxOzdizszN NYGwbXE4W0GQR1XS
NCI-H1395 Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH1TWM2OD1|Mj6yOFMyKM7:TR?= MWjTRW5ITVJ?
NCI-H1993 MnvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTN{LkiyNVgh|ryP Ml2xV2FPT0WU
P31-FUJ MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXpZpdDUUN3ME2zN{41QDl7IN88US=> MnLlV2FPT0WU
LS-513 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HLWGlEPTB;M{WuPFg4QSEQvF2= M176Z3NCVkeHUh?=
SK-MEL-1 M1PMWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPNToh[UUN3ME20NE4{PDl7IN88US=> M{HMNnNCVkeHUh?=
SW684 M2SwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TJWGlEPTB;NEOuPVY3OSEQvF2= M1rFeXNCVkeHUh?=
COR-L88 NGjWXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M330e2lEPTB;NESuNFY3PSEQvF2= M1PnWXNCVkeHUh?=
NCI-H889 NYnMZnZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR3LkCwPFch|ryP M3WzSnNCVkeHUh?=
TALL-1 NGXicpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrQPJJKSzVyPUS2MlEyQTlizszN NG\4clJUSU6JRWK=
KARPAS-299 M1LzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\NTWM2OD12Nz6xPVk{KM7:TR?= NHvwNHlUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin D1 / p27 Kip1 ; 

PubMed: 28382170     


Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1.

p-Cyclin D1 ; 

PubMed: 28035994     


Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control;

p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; 

PubMed: 28035994     


Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;

28382170 28035994
Growth inhibition assay
Cell proliferation ; 

PubMed: 28035994     


Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control.

Cell viability; 

PubMed: 21368880     


H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D. 

28035994 21368880
In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
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Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
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  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A
Smiles CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID