Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Cited by 31 Publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 NXyzNmxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECwNFMyPyEQvF2= NFvUcIpUSU6JRWK=
SK-MEL-30 MnXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jxemlEPTB;MD6wNFA{PTVizszN M33G[nNCVkeHUh?=
NALM-6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMECwN|U3KM7:TR?= NVW3TWR2W0GQR1XS
KYSE-450 NH7vOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMECwOFY6KM7:TR?= NF\1dpBUSU6JRWK=
BHY NEXGXW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLSS4lpUUN3ME2wMlAxODZyMTFOwG0> M3HCWHNCVkeHUh?=
GR-ST MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe1dFhKSzVyPUCuNFAxPjR6IN88US=> MVTTRW5ITVJ?
786-0 NYTvR4h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMECwO|c3KM7:TR?= NYflXphXW0GQR1XS
C-33-A NFTnXGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLCTWM2OD1yLkCwNFg1QCEQvF2= M3nO[3NCVkeHUh?=
BHT-101 NHi4NHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMECxNFYh|ryP MlXqV2FPT0WU
EB2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfnRYh[UUN3ME2wMlAxOTF6IN88US=> MlS4V2FPT0WU
G-361 NWezUpoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfPWnhKSzVyPUCuNFAyOjRizszN MVvTRW5ITVJ?
KE-37 NHXlZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnXbY9KSzVyPUCuNFAyOjhizszN MWLTRW5ITVJ?
MHH-PREB-1 NWrxPGFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMECxOEDPxE1? NVTqR|dKW0GQR1XS
MCF7 NXG2R4JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\iTWM2OD1yLkCwNVU6KM7:TR?= NIjLd3VUSU6JRWK=
LOUCY NWHjZm1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHLTWM2OD1yLkCwNVc2KM7:TR?= NH\0dXZUSU6JRWK=
EW-7 M1fpSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy1V3N3UUN3ME2wMlAxOTd3IN88US=> NFzOV5BUSU6JRWK=
KYSE-510 M13vWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMECyN|Mh|ryP MYPTRW5ITVJ?
SK-MEL-3 M3P0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK3TWM2OD1yLkCwNlY1KM7:TR?= MnXrV2FPT0WU
HAL-01 NEPYeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrBTWM2OD1yLkCwNlk4KM7:TR?= MXvTRW5ITVJ?
HCC2998 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LwbmlEPTB;MD6wNFM{PSEQvF2= NYDBUpdyW0GQR1XS
A375 NEjMOVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17HcmlEPTB;MD6wNFM2KM7:TR?= M3XSUnNCVkeHUh?=
MZ7-mel M3XleGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LoOmlEPTB;MD6wNFM6QSEQvF2= MmezV2FPT0WU
SH-4 NGD1fFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPMPWpKSzVyPUCuNFA1OTdizszN NIq4[INUSU6JRWK=
HT-144 NFjDPJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPDc4N[UUN3ME2wMlAxPDNizszN MUnTRW5ITVJ?
KYSE-140 NETiOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XJcWlEPTB;MD6wNFQ{PSEQvF2= NHjPNJRUSU6JRWK=
PSN1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEC0Olch|ryP NIftSZZUSU6JRWK=
COLO-679 M1LrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r2UWlEPTB;MD6wNFQ6QCEQvF2= MnvtV2FPT0WU
SW620 Mn\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;MTWM2OD1yLkCwOVEyKM7:TR?= M{PrVHNCVkeHUh?=
HGC-27 M17xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr5T5NJUUN3ME2wMlAxPTJ2IN88US=> NFTvd4NUSU6JRWK=
IGROV-1 NXmzbIM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLHR2k5UUN3ME2wMlAxPiEQvF2= NXnCenU3W0GQR1XS
IGR-1 M1n6Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[wVHRKSzVyPUCuNFA3ODFizszN M{WyZXNCVkeHUh?=
EW-1 NHz0eYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TKe2lEPTB;MD6wNFY2OSEQvF2= NIX0THVUSU6JRWK=
769-P M33PZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\RTWM2OD1yLkCwOlc5KM7:TR?= NVvI[lZCW0GQR1XS
HN MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfU[pNKSzVyPUCuNFA3PzlizszN MnnaV2FPT0WU
SIG-M5 M2HBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDMV3ZKSzVyPUCuNFA4OSEQvF2= NGrWdpBUSU6JRWK=
IST-MEL1 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfITWM2OD1yLkCwPFE5KM7:TR?= M1G5[HNCVkeHUh?=
ST486 M4HOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn5NGdKSzVyPUCuNFA5OjVizszN NWnBOmhHW0GQR1XS
ES7 NEHySppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e1VGlEPTB;MD6wNFg1PiEQvF2= NELFc2dUSU6JRWK=
GAK M{HyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrXTWM2OD1yLkCwPFQ5KM7:TR?= MXvTRW5ITVJ?
BB30-HNC NGLwUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPZTWM2OD1yLkCwPFU5KM7:TR?= M13JcXNCVkeHUh?=
IPC-298 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrpXHFKSzVyPUCuNFA6OjdizszN NIW5OYFUSU6JRWK=
NKM-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEC5O|Ih|ryP NVrUO|RUW0GQR1XS
RKO M2HyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7CeXlKSzVyPUCuNFExPDRizszN NXLVO3RnW0GQR1XS
ACN NUPT[WlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jBV2lEPTB;MD6wNVE{OSEQvF2= NH7zUVhUSU6JRWK=
SW1417 M1X3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXtTWM2OD1yLkCxNlI2KM7:TR?= M4ntdnNCVkeHUh?=
SR NV[4VoJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;neo1KSzVyPUCuNFEzOzVizszN Ml73V2FPT0WU
SNG-M MnXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrlcoxKSzVyPUCuNFE{OTdizszN M3zCPXNCVkeHUh?=
CAL-12T M4PpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInJVmlKSzVyPUCuNFE{PDZizszN NUT2TnhFW0GQR1XS
HSC-3 Ml7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULETodwUUN3ME2wMlAyOzV3IN88US=> NHK4fplUSU6JRWK=
DOHH-2 M1vFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmX1TWM2OD1yLkCxOFEzKM7:TR?= M3TuR3NCVkeHUh?=
NB69 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEG1OlUh|ryP NGXYVHZUSU6JRWK=
LC-2-ad MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEG1PFEh|ryP NGi1PYhUSU6JRWK=
RVH-421 MmDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEG2O|Qh|ryP NG\3TlJUSU6JRWK=
TGW Ml7rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEG3N|kh|ryP MkjvV2FPT0WU
HCC1569 M1O0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XzdWlEPTB;MD6wNVc6PyEQvF2= MWjTRW5ITVJ?
CAL-85-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv1TWM2OD1yLkCxPFMzKM7:TR?= MoLkV2FPT0WU
RPMI-8402 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3ieWpQUUN3ME2wMlAyQDV6IN88US=> MkTKV2FPT0WU
THP-1 Moe1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnniTWM2OD1yLkCxPVk5KM7:TR?= Mn2yV2FPT0WU
ONS-76 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\mTWM2OD1yLkCyNFM3KM7:TR?= NFX4NGFUSU6JRWK=
A2780 NGLnSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq4TWM2OD1yLkCyNFc6KM7:TR?= M1\5e3NCVkeHUh?=
RPMI-2650 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET6coFKSzVyPUCuNFIzQTZizszN NWPpTlZkW0GQR1XS
MEL-HO NX3pTmlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX35cHBwUUN3ME2wMlAzOzR6IN88US=> MUTTRW5ITVJ?
MC-CAR MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFy1TY5KSzVyPUCuNFI{PTZizszN MlfVV2FPT0WU
HSC-2 Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HqTGlEPTB;MD6wNlQ3PiEQvF2= MlfyV2FPT0WU
MEL-JUSO NEnGc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrJfVBVUUN3ME2wMlAzPDd|IN88US=> NXzvWpVPW0GQR1XS
CAL-62 NELYXpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEK2NFIh|ryP M1r5b3NCVkeHUh?=
DMS-273 NX[5XWV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljhTWM2OD1yLkCyPFQ4KM7:TR?= NGCxSotUSU6JRWK=
S-117 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEK5NFYh|ryP M3LnRXNCVkeHUh?=
SUP-T1 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEK5OFkh|ryP MVvTRW5ITVJ?
MZ2-MEL Ml;1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjB[3VKSzVyPUCuNFI6PTlizszN M3e5S3NCVkeHUh?=
KYSE-270 NFrjTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvKRotKSzVyPUCuNFI6PzZizszN Mle4V2FPT0WU
CMK NUHkcWNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLSSWpKSzVyPUCuNFMxOjNizszN M3nPT3NCVkeHUh?=
8505C MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MniwTWM2OD1yLkCzNFQh|ryP NVrOXVhwW0GQR1XS
NUGC-3 MlixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHWeFNKSzVyPUCuNFMxPDhizszN M1XacnNCVkeHUh?=
A101D NXThemIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjWe2ZLUUN3ME2wMlA{ODV3IN88US=> M{PRdHNCVkeHUh?=
G-401 NVfYeYhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n3fmlEPTB;MD6wN|A6OyEQvF2= NYnOWJplW0GQR1XS
OVCAR-8 NXvEcVJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnEfZNKSzVyPUCuNFMyODdizszN MXfTRW5ITVJ?
IMR-5 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXlTWM2OD1yLkCzNlQ1KM7:TR?= MnrrV2FPT0WU
DoTc2-4510 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMEOzPVMh|ryP MWXTRW5ITVJ?
HOS NV\vdHJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\qenlXUUN3ME2wMlA{PDd|IN88US=> NXrnbGxYW0GQR1XS
HEC-1 NFfnfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEO2PEDPxE1? MlXqV2FPT0WU
SW756 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEO4NlEh|ryP M3SxR3NCVkeHUh?=
NCI-H64 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnOTWM2OD1yLkCzPFQzKM7:TR?= MVnTRW5ITVJ?
EW-16 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjxS4lKSzVyPUCuNFM6ODlizszN NU\aOmNRW0GQR1XS
CAL-51 NHrZXlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTyeW5rUUN3ME2wMlA1ODB3IN88US=> MmD1V2FPT0WU
KYSE-150 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37LSWlEPTB;MD6wOFAyOSEQvF2= NXjlcXFtW0GQR1XS
SW1710 NYfCUXVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDqV2tKSzVyPUCuNFQxOThizszN NYLtR|FWW0GQR1XS
HuP-T4 M3\1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS4TWM2OD1yLkC0NVE5KM7:TR?= NVLLbIloW0GQR1XS
LB373-MEL-D NWrSW5ZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTERZhsUUN3ME2wMlA1OjN{IN88US=> M4PiW3NCVkeHUh?=
EW-13 MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMES0NFYh|ryP Mmj1V2FPT0WU
HT-29 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTtTWM2OD1yLkC0OFkh|ryP M4XhOnNCVkeHUh?=
SCC-25 M13yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XXUmlEPTB;MD6wOFQ6PCEQvF2= MUfTRW5ITVJ?
REH NFzRdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMES2N|Uh|ryP M3PkUXNCVkeHUh?=
L-363 M1zXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwMES2O|kh|ryP NF74OpNUSU6JRWK=
NCI-H1770 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMES2PVch|ryP NFvFVHhUSU6JRWK=
CHL-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj5T4RKSzVyPUCuNFQ5PTdizszN M1PyfnNCVkeHUh?=
ES1 NYDUR2R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTQU5d1UUN3ME2wMlA1QDh3IN88US=> NX;wVXhIW0GQR1XS
SCC-15 M2XxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMES5NFIh|ryP NF3LUXJUSU6JRWK=
MRK-nu-1 NYTxVI1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3GTWM2OD1yLkC0PVM3KM7:TR?= MnvOV2FPT0WU
PF-382 NGiyRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XzbGlEPTB;MD6wOFk{QSEQvF2= MkS1V2FPT0WU
COLO-680N MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\TcWpKSzVyPUCuNFUxPDdizszN NYfOZ2FqW0GQR1XS
LK-2 NEnzV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTKTWM2OD1yLkC1NFY{KM7:TR?= MoPsV2FPT0WU
NCI-H2342 M4XVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjmXmxTUUN3ME2wMlA2OTF5IN88US=> M4j4NHNCVkeHUh?=
HMV-II M4DQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEWyN|kh|ryP MU\TRW5ITVJ?
PC-14 MljES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEWyOVIh|ryP NVHoTnZTW0GQR1XS
COLO-320-HSR NVGxNYh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;rNlJKSzVyPUCuNFUzQDlizszN MkHWV2FPT0WU
697 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL1VHlKSzVyPUCuNFU{OjNizszN Ml\kV2FPT0WU
NEC8 NIPJe2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3aZoE1UUN3ME2wMlA2PTlizszN M3Pse3NCVkeHUh?=
LCLC-97TM1 NUjzTnA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMEW1PVQh|ryP MYLTRW5ITVJ?
Daoy MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3IeGJxUUN3ME2wMlA2PjF4IN88US=> NV3RTW5EW0GQR1XS
ETK-1 M1nkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTFXY9JUUN3ME2wMlA2Pjd{IN88US=> MWLTRW5ITVJ?
A388 M3\sb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEW2PVUh|ryP NID0fpBUSU6JRWK=
COLO-205 M3zDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vFNGlEPTB;MD6wOVcyPiEQvF2= MUDTRW5ITVJ?
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HCC1143 NWDhRXlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LuN2lEPTB;MD6xO|M6PiEQvF2= Mm\QV2FPT0WU
DJM-1 Mn3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLiZ|RKSzVyPUCuNVc1PTFizszN NHfkWldUSU6JRWK=
BT-474 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzLTWM2OD1yLkG3OFg6KM7:TR?= M1SxdnNCVkeHUh?=
BB65-RCC NXPWU4dQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwMUe1OFUh|ryP NUHjSWNHW0GQR1XS
NCI-H292 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHpTWM2OD1yLkG3OlAyKM7:TR?= M{C3UHNCVkeHUh?=
MKN28 NX3R[IhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjWTWM2OD1yLkG3OlU{KM7:TR?= M1TE[3NCVkeHUh?=
TK10 NHHzfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXjTlRKSzVyPUCuNVc4ODJizszN MVzTRW5ITVJ?
TYK-nu NYfhRWl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPETWM2OD1yLkG3PVQ6KM7:TR?= M4\pRnNCVkeHUh?=
8305C M{LmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUe5O|Eh|ryP MkjzV2FPT0WU
MV-4-11 NV\vWoJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTWR2NIUUN3ME2wMlE4QTd5IN88US=> NUHObI9IW0GQR1XS
NCI-H522 NIfGT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLJTWM2OD1yLkG4NFk1KM7:TR?= MVvTRW5ITVJ?
Hs-578-T MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDEXXlKSzVyPUCuNVgzQTJizszN M1vxTHNCVkeHUh?=
LCLC-103H Mlu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljwTWM2OD1yLkG4OVI4KM7:TR?= MmXQV2FPT0WU
MHH-ES-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fINWlEPTB;MD6xPFYzQSEQvF2= NIr6eVJUSU6JRWK=
NCI-H441 NYi4XmYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMUmxOFgh|ryP MlfTV2FPT0WU
AM-38 NVrZNFdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\yOGQyUUN3ME2wMlE6OjJ3IN88US=> MYnTRW5ITVJ?
SW1783 M1TPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13KfGlEPTB;MD6xPVMxPSEQvF2= NFy3WJpUSU6JRWK=
SK-HEP-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjpTWM2OD1yLkG5OlM4KM7:TR?= NW\VcFJXW0GQR1XS
OAW-28 M{jVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDmb|Z6UUN3ME2wMlIxOTd6IN88US=> M2X5XXNCVkeHUh?=
TE-15 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\3XGlEPTB;MD6yNFI2OiEQvF2= NHf5OWNUSU6JRWK=
HCE-4 NXvYRo8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\1O|RKSzVyPUCuNlAzQDRizszN NVHmXHEyW0GQR1XS
JiyoyeP-2003 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7qTWM2OD1yLkKwN|M3KM7:TR?= NHq2SFBUSU6JRWK=
OVCAR-4 MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKzUIhKSzVyPUCuNlA3OjhizszN NYXLbZF2W0GQR1XS
SNU-449 M3P2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjzRW1KSzVyPUCuNlA4QTdizszN NXzFT2VWW0GQR1XS
SBC-5 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXOTWM2OD1yLkKxNlE2KM7:TR?= MlP0V2FPT0WU
T84 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K1[mlEPTB;MD6yNVI1QCEQvF2= NH\uVFBUSU6JRWK=
LP-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMkGzNFIh|ryP MUHTRW5ITVJ?
MG-63 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjpTWM2OD1yLkKxN|gzKM7:TR?= NGnKTopUSU6JRWK=
OAW-42 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMkG0O|gh|ryP NIqzU45USU6JRWK=
L-540 M1nPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3YUIc{UUN3ME2wMlIyPTl6IN88US=> NVvPV|dPW0GQR1XS
RH-1 NVuyeY1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYewR4xHUUN3ME2wMlIzOjR{IN88US=> MnOwV2FPT0WU
HCT-15 M2Cxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rjfWlEPTB;MD6yNlQ5PCEQvF2= NWThboRxW0GQR1XS
OCUB-M Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLjTWM2OD1yLkKyOFg5KM7:TR?= M{jx[HNCVkeHUh?=
GP5d MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDzVIRVUUN3ME2wMlIzPTJ6IN88US=> NXfC[ZcyW0GQR1XS
NCI-H2030 NHfhbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTwdmppUUN3ME2wMlIzPzN2IN88US=> NID5TllUSU6JRWK=
ML-2 M3Hvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LnWmlEPTB;MD6yNlg5QSEQvF2= NU[zeWRRW0GQR1XS
CAL-39 NF;qUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;iZXFKSzVyPUCuNlI6OzZizszN Mnr6V2FPT0WU
MIA-PaCa-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMkOyPFch|ryP Mn\1V2FPT0WU
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DB M1Tu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMkO0N|gh|ryP NHe4bXJUSU6JRWK=
NCI-H596 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTI[5hKSzVyPUCuNlM2PzFizszN NV;jUIdVW0GQR1XS
SW1990 MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrXXnpKSzVyPUCuNlM6PDZizszN MoPvV2FPT0WU
P30-OHK Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPpTWM2OD1yLkK0NFUh|ryP MUnTRW5ITVJ?
ALL-PO NI\uXJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT6TWM2OD1yLkK0NVY6KM7:TR?= M4TEXHNCVkeHUh?=
Saos-2 NGPsRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMkS1O|Eh|ryP MlnIV2FPT0WU
MFH-ino MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7PUpBsUUN3ME2wMlI1Pjl{IN88US=> M1jqTHNCVkeHUh?=
OE33 NHXrNJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT3UpRCUUN3ME2wMlI2OTFizszN NVTUZo9kW0GQR1XS
Calu-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMkWyPVch|ryP MXHTRW5ITVJ?
HT M4\BSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj5d3A2UUN3ME2wMlI2PjJzIN88US=> MkDmV2FPT0WU
LXF-289 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMkW5PFQh|ryP MYrTRW5ITVJ?
KGN NH\nRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMk[wPFkh|ryP MVXTRW5ITVJ?
NCI-H1417 MlfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnGclhYUUN3ME2wMlI3PTJ2IN88US=> Ml7LV2FPT0WU
SF126 NX\DcGIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXTXpJKSzVyPUCuNlc{ODJizszN M17sU3NCVkeHUh?=
SAS MnfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMkezNFgh|ryP M4jvUXNCVkeHUh?=
22RV1 NEOyfYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnRT3FKSzVyPUCuNlc{PzhizszN NEHIW2RUSU6JRWK=
GI-1 M37jVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP0b5hKSzVyPUCuNlc1QDdizszN NGXBT29USU6JRWK=
ES3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwMke3OlMh|ryP M2GzfnNCVkeHUh?=
NB1 NHnEUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkOxTWM2OD1yLkK3PFc3KM7:TR?= MniyV2FPT0WU
NCI-H650 NHuze4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofzTWM2OD1yLkK4N|AzKM7:TR?= NG\USIZUSU6JRWK=
IST-MES1 NH7vWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fNSGlEPTB;MD6yPFU2PCEQvF2= Mme1V2FPT0WU
UM-UC-3 M1rCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMkmxOEDPxE1? NIrZPFJUSU6JRWK=
CAL-120 M4fUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\rTWM2OD1yLkK5OlMyKM7:TR?= NV:wTHZbW0GQR1XS
UACC-62 M4j1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\STWM2OD1yLkOwNlQyKM7:TR?= NYTuNIY6W0GQR1XS
TE-11 NHrZdmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXOxephTUUN3ME2wMlMxOjR7IN88US=> MXTTRW5ITVJ?
MKN1 NVPlU3VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwM{CzOkDPxE1? MlzRV2FPT0WU
KS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwW2lEPTB;MD6zNFUzPiEQvF2= NYSweGI{W0GQR1XS
GCIY MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwM{GwNFIh|ryP Mkj0V2FPT0WU
OVCAR-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfpTWM2OD1yLkOxNVA3KM7:TR?= Mn7kV2FPT0WU
U-266 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj2VGRKSzVyPUCuN|EyPDdizszN NIHPcVVUSU6JRWK=
Calu-1 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwM{GyPFkh|ryP NILNVZlUSU6JRWK=
SK-LMS-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XXcGlEPTB;MD6zNVQzQSEQvF2= M1m4O3NCVkeHUh?=
COLO-741 M3;3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT4VY1zUUN3ME2wMlMyPjF2IN88US=> NHvScoVUSU6JRWK=
RPMI-8226 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfOTWM2OD1yLkOxOlQyKM7:TR?= NEPV[odUSU6JRWK=
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COR-L105 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXISJFKSzVyPUCuN|IzOThizszN M{L2W3NCVkeHUh?=
IM-9 NV;obI1[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLpRlJKSzVyPUCuN|MxOjFizszN MmfFV2FPT0WU
TE-12 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnWTWM2OD1yLkOzN|E4KM7:TR?= NX3qUpoxW0GQR1XS
KG-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTBwM{O0N|Ih|ryP Ml\hV2FPT0WU
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EW-24 M373UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVn2RYJ[UUN3ME2wMlM{QTh2IN88US=> MVnTRW5ITVJ?
SF295 NYflVotTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;KUWlEPTB;MD6zN|k6QSEQvF2= M1jpe3NCVkeHUh?=
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NCI-H2405 NIHxXWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPQ[mtYUUN3ME2wMlM1PzN{IN88US=> NEjQS5hUSU6JRWK=
NCI-H2009 M4TucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrNd45KSzVyPUCuN|Q4OzlizszN M4PGcHNCVkeHUh?=
LB1047-RCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwM{W4NVUh|ryP MYrTRW5ITVJ?
KNS-81-FD NVrmcZp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvGTWM2OD1yLkO2OlY4KM7:TR?= NY\U[GxUW0GQR1XS
HOP-92 MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH5WVJ7UUN3ME2wMlM3QDNizszN Mn;yV2FPT0WU
L-428 M3\vXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHpdpk6UUN3ME2wMlM4ODF4IN88US=> NVLVRYtvW0GQR1XS
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NCI-H1792 MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\WUpdiUUN3ME2wMlM4PjV3IN88US=> M1fufHNCVkeHUh?=
HuH-7 Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K0Z2lEPTB;MD6zO|kyKM7:TR?= NGC0T2NUSU6JRWK=
AGS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme0TWM2OD1yLkO4OlM5KM7:TR?= NEHkW4VUSU6JRWK=
HT-1197 NHnoW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwM{m0OkDPxE1? NHvV[oNUSU6JRWK=
CGTH-W-1 MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPUcFlKSzVyPUCuN|k6OTNizszN MnfMV2FPT0WU
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HuO-3N1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwNECwOVUh|ryP MojDV2FPT0WU
VMRC-RCZ NUjqRVlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzTTWM2OD1yLkSwN|A{KM7:TR?= Mln5V2FPT0WU
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NCI-H1437 M4fVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwNEC4NFUh|ryP Mmm1V2FPT0WU
U-118-MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNEC5NFQh|ryP MVrTRW5ITVJ?
NCI-H1734 NUmwe2dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvtOZNKSzVyPUCuOFIxOTNizszN MkfIV2FPT0WU
HDLM-2 NXPyS3UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj3d29KSzVyPUCuOFIxOzNizszN NGPtcW5USU6JRWK=
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CAMA-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7rTYRKSzVyPUCuOFM3OjZizszN MULTRW5ITVJ?
MONO-MAC-6 NEDRN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX1TWM2OD1yLkSzPFQ6KM7:TR?= MWnTRW5ITVJ?
LB831-BLC NG\lVY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rrXWlEPTB;MD60OFM4OSEQvF2= MUDTRW5ITVJ?
SW982 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwNES1Nlgh|ryP NGHEeolUSU6JRWK=
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BFTC-909 M1vNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNEWyPVkh|ryP MU\TRW5ITVJ?
MEG-01 M3P5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfteJdKSzVyPUCuOFU{PzNizszN M2Di[XNCVkeHUh?=
M14 NX3uXo12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFy3Wm1KSzVyPUCuOFU6PzlizszN MU\TRW5ITVJ?
MPP-89 NYXLO5lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7aSlliUUN3ME2wMlQ3OjV4IN88US=> MULTRW5ITVJ?
HCC1937 NXP5fZF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETkSXhKSzVyPUCuOFY{QDRizszN NGDx[GxUSU6JRWK=
SW837 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HGcmlEPTB;MD60OlczOiEQvF2= NHjZXGxUSU6JRWK=
DU-145 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\ZTWM2OD1yLkS2O|I6KM7:TR?= NXnKXWNCW0GQR1XS
LB996-RCC MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LOdmlEPTB;MD60O|A2PCEQvF2= M4nRN3NCVkeHUh?=
C8166 M2\GUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwNEe0JO69VQ>? NXvYSo57W0GQR1XS
MOLT-4 M4\JZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwNEe3N|Qh|ryP M1HkV3NCVkeHUh?=
DMS-53 MnqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLYXnRKSzVyPUCuOFc5ODlizszN NXm1NXBzW0GQR1XS
TE-5 NYLj[mxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwNEizNFUh|ryP NVPCXlBtW0GQR1XS
KYSE-520 NGrCb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfZTWM2OD1yLkS4N|Q{KM7:TR?= Ml3jV2FPT0WU
Detroit562 M33PSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq0dm9KSzVyPUCuOFg5PiEQvF2= NEnYTnhUSU6JRWK=
SIMA MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF31eYFKSzVyPUCuOFk1OTdizszN NHfzU|lUSU6JRWK=
NCI-H1651 NUiwXolxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNEm2O{DPxE1? M{jwZnNCVkeHUh?=
HCC1599 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH23WXlKSzVyPUCuOFk6PTVizszN MnW0V2FPT0WU
ABC-1 NX71OIFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwNUC0PVYh|ryP M4jkN3NCVkeHUh?=
CAL-33 NFfSOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK0SFdKSzVyPUCuOVA5PDRizszN MnzxV2FPT0WU
OPM-2 NH7M[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDMSnJKSzVyPUCuOVA6OzdizszN NI\wUoJUSU6JRWK=
RPMI-7951 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLwTWM2OD1yLkWwPVU4KM7:TR?= MmPXV2FPT0WU
HT-1080 M{PrUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL3eWtNUUN3ME2wMlUyOTF7IN88US=> M{PQd3NCVkeHUh?=
LC4-1 NFXGOGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzDTWM2OD1yLkWxOFA{KM7:TR?= MmX3V2FPT0WU
OVCAR-3 NGPhb|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWH1empRUUN3ME2wMlUyPTdizszN MVPTRW5ITVJ?
CAPAN-1 MmrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\KUmlEPTB;MD61NlI5QCEQvF2= MVHTRW5ITVJ?
SK-OV-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLBWYt4UUN3ME2wMlUzPDN2IN88US=> NXnIfXlRW0GQR1XS
HuP-T3 MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fsUWlEPTB;MD61NlgzPyEQvF2= M{\Ob3NCVkeHUh?=
NCI-H838 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16wbWlEPTB;MD61Nlg1QSEQvF2= M4e5VHNCVkeHUh?=
K5 NEXzUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHQTWM2OD1yLkWzNlAyKM7:TR?= MkLHV2FPT0WU
CAL-72 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO0dW41UUN3ME2wMlU{Ozh5IN88US=> M2P3TnNCVkeHUh?=
NH-12 MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\DTWlEPTB;MD61N|k2QSEQvF2= M4PrZnNCVkeHUh?=
SNB75 M{\JNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwNUW3N{DPxE1? MYfTRW5ITVJ?
BPH-1 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwNU[zOFQh|ryP NVvxdmFoW0GQR1XS
NOMO-1 M2iyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTLSph3UUN3ME2wMlU3Ozd{IN88US=> MYnTRW5ITVJ?
G-402 NVflXod3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHtWJhSUUN3ME2wMlU3PDl7IN88US=> MXrTRW5ITVJ?
NCI-H2052 MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3MTWM2OD1yLkW2O|QyKM7:TR?= NXXvRVdLW0GQR1XS
RCM-1 NWntVVB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwNUexOlYh|ryP MVjTRW5ITVJ?
COR-L279 M33sO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwNUexPFUh|ryP NVK2XmlnW0GQR1XS
A253 MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS3SlBKSzVyPUCuOVc2OjVizszN MXvTRW5ITVJ?
SK-MM-2 NV3McXhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzmZVZKSzVyPUCuOVc3PzlizszN MnvEV2FPT0WU
NCI-H1703 NF3odIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwNUm0Nlch|ryP NXK3TJVuW0GQR1XS
UACC-257 M{LYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3exSGlEPTB;MD61PVQ5PyEQvF2= MXHTRW5ITVJ?
KALS-1 M1zpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LaOmlEPTB;MD62NFAyOSEQvF2= NHjsV25USU6JRWK=
ES5 NYPLWWMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES1e5dKSzVyPUCuOlA1QCEQvF2= MW\TRW5ITVJ?
MHH-CALL-2 NXPUXJA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLnSo9KSzVyPUCuOlA5QDhizszN MYnTRW5ITVJ?
ChaGo-K-1 NUe4TWR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGyeY96UUN3ME2wMlYyOjJ7IN88US=> M3XtRXNCVkeHUh?=
TGBC1TKB Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwNkG5PEDPxE1? M{T2b3NCVkeHUh?=
KU-19-19 NUHneVJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj6TWM2OD1yLk[0OVg3KM7:TR?= NYm2bWRKW0GQR1XS
COLO-684 MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTuWJM6UUN3ME2wMlY2PjFzIN88US=> NEHZbnZUSU6JRWK=
LS-1034 NI\VcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XNV2lEPTB;MD62OVgyQSEQvF2= MkTDV2FPT0WU
RT-112 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3DTWM2OD1yLk[2OVg4KM7:TR?= M1;iOnNCVkeHUh?=
Capan-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3JTWM2OD1yLk[2OlIzKM7:TR?= MXPTRW5ITVJ?
HSC-4 NHi4W4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v2XmlEPTB;MD62OlY6QCEQvF2= MXXTRW5ITVJ?
COLO-824 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLDc4JWUUN3ME2wMlY4QDJ|IN88US=> MWHTRW5ITVJ?
NCI-H2170 NH3xNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnu[mNKSzVyPUCuOlgzPThizszN MnXvV2FPT0WU
GDM-1 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TK[2lEPTB;MD62PFQ6PCEQvF2= NFPDcYVUSU6JRWK=
KP-4 NXfPco9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TKeGlEPTB;MD62PVU4OyEQvF2= NHS5N4JUSU6JRWK=
VA-ES-BJ MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHPZXMyUUN3ME2wMlY6QTh4IN88US=> NETxVGNUSU6JRWK=
KM-H2 NHf2RnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jm[WlEPTB;MD63NFA6OSEQvF2= MVXTRW5ITVJ?
HH M2fQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLpTWM2OD1yLkewOlYzKM7:TR?= NY\jdodIW0GQR1XS
DK-MG MmH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PCSGlEPTB;MD63NVAyPiEQvF2= MoDvV2FPT0WU
VM-CUB-1 Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP2TWM2OD1yLkexNlU6KM7:TR?= M4nZcHNCVkeHUh?=
COLO-829 NETNfZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\ETWM2OD1yLkexPVg2KM7:TR?= NXLrNGMzW0GQR1XS
OMC-1 M3LybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjpe5hKSzVyPUCuO|IyODRizszN Mlm0V2FPT0WU
NB12 M4PScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTMO4I4UUN3ME2wMlczPTB2IN88US=> MY\TRW5ITVJ?
NCI-H28 NUnpe|hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHRW5lKSzVyPUCuO|QxQDNizszN NHHuW3NUSU6JRWK=
A673 Mn7KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwN{WxO|ch|ryP NVvmXGZkW0GQR1XS
LB2241-RCC M{K3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3lTWM2OD1yLke2NFg4KM7:TR?= M2PkUnNCVkeHUh?=
CCRF-CEM MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTjTWM2OD1yLke3NFUzKM7:TR?= MYLTRW5ITVJ?
NCI-H510A Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\TeoJlUUN3ME2wMlc4OTh4IN88US=> NWjNfFZMW0GQR1XS
SW48 M3;nbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwN{ezN|Mh|ryP NHrGSpBUSU6JRWK=
NCI-H2081 M4[5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPBVnZKSzVyPUCuO|gyPDdizszN NVrBVI82W0GQR1XS
RMG-I M3XXU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXVXXJmUUN3ME2wMlc5OjF{IN88US=> Mo\TV2FPT0WU
LU-99A NWK3O5dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[5[2pEUUN3ME2wMlc5PDF|IN88US=> MYPTRW5ITVJ?
KP-N-YS MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjOTWM2OD1yLke4PVIyKM7:TR?= NXjZU5M4W0GQR1XS
MDA-MB-231 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LtWmlEPTB;MD64NFE{OSEQvF2= MmK1V2FPT0WU
U031 MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\BTmlEPTB;MD64NVQzOyEQvF2= M33jenNCVkeHUh?=
EVSA-T NGmxbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwOEG2O|Ih|ryP NY\jdXV7W0GQR1XS
MDA-MB-157 Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TSU2lEPTB;MD64NlI4OSEQvF2= NVvhUVFVW0GQR1XS
EHEB M3PEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwOEKyO|Yh|ryP MVXTRW5ITVJ?
KINGS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDGPZNKSzVyPUCuPFI2PTVizszN NHjlVFZUSU6JRWK=
23132-87 M{PWSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwOEK4OFMh|ryP MmT2V2FPT0WU
EFO-21 NUHFV|dbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwOESwPFkh|ryP MVnTRW5ITVJ?
DOK MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwOES4JO69VQ>? MYnTRW5ITVJ?
NCI-H2171 NUewZ4tjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYm1UWxiUUN3ME2wMlg1QTZizszN M2rwXnNCVkeHUh?=
NCI-SNU-5 MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETuSnlKSzVyPUCuPFU2PyEQvF2= MV7TRW5ITVJ?
SK-N-DZ NFzhVoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\xWGlEPTB;MD64OVk1OyEQvF2= NIK1OlFUSU6JRWK=
SNU-C2B MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWK5eGtbUUN3ME2wMlg3QDBzIN88US=> NHGzfXhUSU6JRWK=
CP66-MEL MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\JU5k2UUN3ME2wMlg4OTFizszN M2XndXNCVkeHUh?=
SN12C M1zJOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3Xrc2lEPTB;MD64PFY{PyEQvF2= NUHVPYlNW0GQR1XS
A172 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwOEi2PVgh|ryP NILPN2VUSU6JRWK=
NCI-H2347 NXnjU4Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jV[2lEPTB;MD64PFc2OyEQvF2= NUPKe4FjW0GQR1XS
NCI-H2228 M2PFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwOEmzN|kh|ryP Mnj3V2FPT0WU
SNU-387 M2C4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLLfFFPUUN3ME2wMlkxOjZ2IN88US=> M2TZcnNCVkeHUh?=
SK-MEL-24 M4nVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPnbXlVUUN3ME2wMlkyOzR2IN88US=> NV7CdFBlW0GQR1XS
MDA-MB-468 M4DOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwOUG3N{DPxE1? MkfaV2FPT0WU
NCI-H1694 NYDmSI9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwOUG4O|Yh|ryP NX[yWZlkW0GQR1XS
CCF-STTG1 NXXsZ3JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXLdYlFUUN3ME2wMlkzPjN5IN88US=> M1HZS3NCVkeHUh?=
K052 NXvUbGtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS0TWM2OD1yLkm0NFQ4KM7:TR?= MnTPV2FPT0WU
NCI-H446 MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHyRpNqUUN3ME2wMlk2ODFizszN NVLROGZDW0GQR1XS
MFE-280 NHzPcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnjTWM2OD1yLkm2NlkyKM7:TR?= NVvlbYNVW0GQR1XS
KU812 M13ufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTBwOUmzPFkh|ryP MYHTRW5ITVJ?
MDA-MB-361 MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfQRXRKSzVyPUCuPVk4PzdizszN MVPTRW5ITVJ?
Raji NGrHSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjkOnJKSzVyPUGuNFIzPjdizszN NYnuXoxwW0GQR1XS
TE-6 Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PuWmlEPTB;MT6wN|U3PiEQvF2= MYrTRW5ITVJ?
CAL-148 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljCTWM2OD1zLkC0OFQ{KM7:TR?= NITQcVRUSU6JRWK=
NCI-H1963 Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTFwMES1OVMh|ryP MW\TRW5ITVJ?
SK-N-AS MonlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfwdJBKSzVyPUGuNFQ3QDVizszN M1X1WnNCVkeHUh?=
RERF-LC-MS NX7CfIN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnNTGhKSzVyPUGuNFY{PDlizszN MmnYV2FPT0WU
BEN NEjYU4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi2R4RRUUN3ME2xMlA4OTN5IN88US=> M3;ZTXNCVkeHUh?=
CAS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnqfW5GUUN3ME2xMlA6OTJ|IN88US=> Ml\JV2FPT0WU
SW780 NWW4cYJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFwMEmxPFEh|ryP MUPTRW5ITVJ?
LU-65 NWLGVHNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV71WpdkUUN3ME2xMlA6PDFizszN NIfXbXZUSU6JRWK=
D-283MED MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7YRpNKSzVyPUGuNVIzPzJizszN NGHWPI5USU6JRWK=
HCC2157 M3jhSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PlVmlEPTB;MT6xN|Y1OiEQvF2= MmXRV2FPT0WU
RCC10RGB NGnsTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Di[2lEPTB;MT6xOFAxPiEQvF2= Mk\3V2FPT0WU
PLC-PRF-5 M3TJcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjEXXpJUUN3ME2xMlE2OjJ7IN88US=> M3X3OnNCVkeHUh?=
H4 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFizcnBKSzVyPUGuNVU1OzlizszN MmPOV2FPT0WU
TUR NGDkb5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH23[G1KSzVyPUGuNVU4PTJizszN MYjTRW5ITVJ?
NCI-H2141 NYXkOFVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTFwMUi5OFYh|ryP NGjKUnBUSU6JRWK=
PFSK-1 NHrMepZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXBToVYUUN3ME2xMlIxPTN{IN88US=> MnfsV2FPT0WU
SK-MEL-28 M1rUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GzVmlEPTB;MT6yN|IzOSEQvF2= M2fIPXNCVkeHUh?=
SCC-9 NHfhO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHG4TFlKSzVyPUGuNlM3PjVizszN NWPldopXW0GQR1XS
T47D M2\SXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXYZZlOUUN3ME2xMlI{Pjl4IN88US=> MkLZV2FPT0WU
TCCSUP NHr5PFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LXV2lEPTB;MT6yOVAzQSEQvF2= M{TWfXNCVkeHUh?=
SU-DHL-1 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFwMkWxNVgh|ryP M1q3SnNCVkeHUh?=
HL-60 M4HGU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFwMkW1PFgh|ryP MnuzV2FPT0WU
NCI-H1436 NGrJXYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrwWXFKSzVyPUGuNlYyPDlizszN M1XJenNCVkeHUh?=
DMS-114 NFHvR2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFwMk[2N|Ih|ryP MlftV2FPT0WU
BOKU M3L6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvnRXBSUUN3ME2xMlI5ODl3IN88US=> M4fuc3NCVkeHUh?=
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NCI-H187 M1jsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqwT2xXUUN3ME21MlkzQTh7IN88US=> NV[2UGpjW0GQR1XS
LU-165 NED4[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTVwOUmwNFIh|ryP NVrydYhyW0GQR1XS
YAPC NIH1VlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnzS3dKSzVyPUWuPVkxPjhizszN MYjTRW5ITVJ?
LU-139 NHqyc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PUU2lEPTB;Nj6wPFM3QCEQvF2= MlG2V2FPT0WU
D-502MG NV3QPHk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTJTWM2OD14LkOyNFQ4KM7:TR?= NVzkNIx4W0GQR1XS
IST-SL1 NWK0VZJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DQXGlEPTB;Nj61N|k1QCEQvF2= MX7TRW5ITVJ?
DG-75 M{\6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK2NmdKSzVyPU[uPFg4QDZizszN MXrTRW5ITVJ?
NCI-H1155 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi3OVJKSzVyPU[uPVU2QDFizszN MYnTRW5ITVJ?
EFE-184 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHKTWM2OD15LkOxOlk2KM7:TR?= NGTuV2hUSU6JRWK=
AsPC-1 NG\KSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTdwNEi4NFch|ryP MkHiV2FPT0WU
SW948 M1Li[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTdwNUizPVUh|ryP M4nSZXNCVkeHUh?=
NCI-H524 NFvwTm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{f6fWlEPTB;OT61PFYzQCEQvF2= M1niXnNCVkeHUh?=
KOSC-2 M4exOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHP[|lKSzVyPUmuOlI5OzRizszN Ml;zV2FPT0WU
T-24 NEXSSIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LKVWlEPTB;OT65OFQyPSEQvF2= NYXvV|V7W0GQR1XS
NCI-H748 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHzR3VKSzVyPUGwMlY{QTdizszN MXTTRW5ITVJ?
NCI-H23 NHn5epRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHBTWM2OD1zMD62OFQzKM7:TR?= NEX4Z2xUSU6JRWK=
UACC-812 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFzLkexO{DPxE1? M{Lkd3NCVkeHUh?=
SCLC-21H M{DVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF{LkG1OVEh|ryP NF7iO5ZUSU6JRWK=
NCI-SNU-16 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7wUXdKSzVyPUGzMlEzPThizszN M2\W[3NCVkeHUh?=
HD-MY-Z M2THUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;sTWM2OD1zND62N|Y{KM7:TR?= NWfsPXlQW0GQR1XS
SK-N-FI NGnUdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmixTWM2OD1zND64PVEzKM7:TR?= MVLTRW5ITVJ?
LB647-SCLC Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGOxcZdKSzVyPUG1MlcyQTVizszN MYTTRW5ITVJ?
NCI-H345 NFrTbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLs[IFKSzVyPUG3MlM1OyEQvF2= MVzTRW5ITVJ?
NCI-H1563 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TUVmlEPTB;MUiuO|YxOSEQvF2= M1z4c3NCVkeHUh?=
RL M1Lqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLhW4trUUN3ME2yNU4zPjV4IN88US=> MXXTRW5ITVJ?
KY821 NHryeXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PGb2lEPTB;MkKuNFU2OyEQvF2= MofwV2FPT0WU
JVM-3 NIHl[|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn3S2VKSzVyPUK1MlA1OTNizszN NIrRdWtUSU6JRWK=
NCI-H1793 NFzsNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q3N2lEPTB;MkiuOVQ6QSEQvF2= MlHVV2FPT0WU
LU-134-A MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojPTWM2OD1|MD6yNFM4KM7:TR?= NULHOW5oW0GQR1XS
NCI-H1395 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL1V2I1UUN3ME2zNk4zPDNzIN88US=> MYPTRW5ITVJ?
NCI-H1993 NYG3XGhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT3TWM2OD1|Mj64NlE5KM7:TR?= MnexV2FPT0WU
P31-FUJ MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvUbZVKSzVyPUOzMlQ5QTlizszN M{HlRnNCVkeHUh?=
LS-513 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTN3Lki4O|kh|ryP NEDqemhUSU6JRWK=
SK-MEL-1 NFrXWm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fzOGlEPTB;NECuN|Q6QSEQvF2= NETMcWdUSU6JRWK=
SW684 NV31NYhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37ycWlEPTB;NEOuPVY3OSEQvF2= NX2wT4JnW0GQR1XS
COR-L88 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnjNoxKSzVyPUS0MlA3PjVizszN M{i0SXNCVkeHUh?=
NCI-H889 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTDTXJKSzVyPUS1MlAxQDdizszN NHzR[W1USU6JRWK=
TALL-1 NY\6SVBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDlTWM2OD12Nj6xNVk6KM7:TR?= NX7oPGRiW0GQR1XS
KARPAS-299 NV;vUGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn74TWM2OD12Nz6xPVk{KM7:TR?= NHH5OJNUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID