Obatoclax Mesylate (GX15-070)

For research use only.

Catalog No.S1057

80 publications

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Selleck's Obatoclax Mesylate (GX15-070) has been cited by 80 publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\3ZplpUUN3ME2wMlAxODB|MUeg{txO MUXTRW5ITVJ?
SK-MEL-30 M2XhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\oTWM2OD1yLkCwNFM2PSEQvF2= NY[2cGFVW0GQR1XS
NALM-6 M1;Q[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PjNWlEPTB;MD6wNFA{PTZizszN MnT2V2FPT0WU
KYSE-450 NH7XVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7VTWM2OD1yLkCwNFQ3QSEQvF2= NV7vTohXW0GQR1XS
BHY NF[3emlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV22PWlmUUN3ME2wMlAxODZyMTFOwG0> NIfSeYVUSU6JRWK=
GR-ST MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHuTWM2OD1yLkCwNFY1QCEQvF2= NHnOTIJUSU6JRWK=
786-0 NF3DN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nUWWlEPTB;MD6wNFA4PzZizszN M3Phc3NCVkeHUh?=
C-33-A M4HD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMECwPFQ5KM7:TR?= M4m3RXNCVkeHUh?=
BHT-101 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLuTWM2OD1yLkCwNVA3KM7:TR?= NHrjTnpUSU6JRWK=
EB2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPieZJrUUN3ME2wMlAxOTF6IN88US=> M{jib3NCVkeHUh?=
G-361 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojoTWM2OD1yLkCwNVI1KM7:TR?= MoTXV2FPT0WU
KE-37 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTLWJNDUUN3ME2wMlAxOTJ6IN88US=> MoPZV2FPT0WU
MHH-PREB-1 NVT3O5c1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC1TWM2OD1yLkCwNVQh|ryP M4KxSXNCVkeHUh?=
MCF7 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHHTWM2OD1yLkCwNVU6KM7:TR?= MnWzV2FPT0WU
LOUCY MnLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrMTWM2OD1yLkCwNVc2KM7:TR?= MUDTRW5ITVJ?
EW-7 NGTrcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMECxO|Uh|ryP MUfTRW5ITVJ?
KYSE-510 NF\PbIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jBNGlEPTB;MD6wNFI{OyEQvF2= MVjTRW5ITVJ?
SK-MEL-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMECyOlQh|ryP MYrTRW5ITVJ?
HAL-01 NFzOW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnLZ4Q6UUN3ME2wMlAxOjl5IN88US=> M2jjWnNCVkeHUh?=
HCC2998 NHXoWHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv6[ZpKSzVyPUCuNFA{OzVizszN NV3GbWFYW0GQR1XS
A375 M{[1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fRbmlEPTB;MD6wNFM2KM7:TR?= MWPTRW5ITVJ?
MZ7-mel NF\PU4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvLTWM2OD1yLkCwN|k6KM7:TR?= NFnWfZhUSU6JRWK=
SH-4 NYj3dZUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LwRmlEPTB;MD6wNFQyPyEQvF2= NGLnT3hUSU6JRWK=
HT-144 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwMEC0N{DPxE1? M2\K[nNCVkeHUh?=
KYSE-140 M1PuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwMEC0N|Uh|ryP NFzJXpZUSU6JRWK=
PSN1 NFzUbWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{iy[GlEPTB;MD6wNFQ3PyEQvF2= M3rp[nNCVkeHUh?=
COLO-679 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\RdFJnUUN3ME2wMlAxPDl6IN88US=> MoDnV2FPT0WU
SW620 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEC1NVEh|ryP NGnMZYRUSU6JRWK=
HGC-27 MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\VZXBKSzVyPUCuNFA2OjRizszN MVTTRW5ITVJ?
IGROV-1 Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHYeFRHUUN3ME2wMlAxPiEQvF2= NYfRfpp6W0GQR1XS
IGR-1 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3LfIhKSzVyPUCuNFA3ODFizszN M3y2eHNCVkeHUh?=
EW-1 NVjtSGhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrHTWM2OD1yLkCwOlUyKM7:TR?= MlnSV2FPT0WU
769-P M3:5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH75[pJKSzVyPUCuNFA3PzhizszN MY\TRW5ITVJ?
HN NIHBdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF72XopKSzVyPUCuNFA3PzlizszN MoDIV2FPT0WU
SIG-M5 NYHwOox5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj5dlRKSzVyPUCuNFA4OSEQvF2= Mn73V2FPT0WU
IST-MEL1 M3\6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fVZWlEPTB;MD6wNFgyQCEQvF2= Mo\4V2FPT0WU
ST486 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTnTWM2OD1yLkCwPFI2KM7:TR?= NVW4TG5yW0GQR1XS
ES7 NHjKVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PldmlEPTB;MD6wNFg1PiEQvF2= MXnTRW5ITVJ?
GAK MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLhVIlNUUN3ME2wMlAxQDR6IN88US=> M2K3eHNCVkeHUh?=
BB30-HNC MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7iPZN3UUN3ME2wMlAxQDV6IN88US=> M{X4fHNCVkeHUh?=
IPC-298 NVS1T2dXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXafmpnUUN3ME2wMlAxQTJ5IN88US=> M4TVNXNCVkeHUh?=
NKM-1 NGHZOHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3RRppKSzVyPUCuNFA6PzJizszN Ml:1V2FPT0WU
RKO MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjKR5ZKSzVyPUCuNFExPDRizszN M2L4VHNCVkeHUh?=
ACN NEPv[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Did2lEPTB;MD6wNVE{OSEQvF2= M{e3dHNCVkeHUh?=
SW1417 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEGyNlUh|ryP M1zNbHNCVkeHUh?=
SR NWOzdoZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEGyN|Uh|ryP Mn\5V2FPT0WU
SNG-M MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMEGzNVch|ryP M4CxWXNCVkeHUh?=
CAL-12T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\ROGlEPTB;MD6wNVM1PiEQvF2= M2fTUXNCVkeHUh?=
HSC-3 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\DWG05UUN3ME2wMlAyOzV3IN88US=> Moe5V2FPT0WU
DOHH-2 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\5ZollUUN3ME2wMlAyPDF{IN88US=> MmryV2FPT0WU
NB69 NH;STXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nKTmlEPTB;MD6wNVU3PSEQvF2= NFXkNGNUSU6JRWK=
LC-2-ad MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvmOmpKSzVyPUCuNFE2QDFizszN MWPTRW5ITVJ?
RVH-421 NHr1VndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorGTWM2OD1yLkCxOlc1KM7:TR?= MVPTRW5ITVJ?
TGW NUniOJhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEG3N|kh|ryP NUjBOWlqW0GQR1XS
HCC1569 M3HVU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r4ZmlEPTB;MD6wNVc6PyEQvF2= M37KU3NCVkeHUh?=
CAL-85-1 NFWweVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMEG4N|Ih|ryP NXPtWJF3W0GQR1XS
RPMI-8402 Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi4T5ROUUN3ME2wMlAyQDV6IN88US=> MY\TRW5ITVJ?
THP-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DyNmlEPTB;MD6wNVk6QCEQvF2= MonvV2FPT0WU
ONS-76 NWq3O4x2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMEKwN|Yh|ryP Ml7YV2FPT0WU
A2780 M4rPVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEKwO|kh|ryP NF\ySJpUSU6JRWK=
RPMI-2650 Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vQZWlEPTB;MD6wNlI6PiEQvF2= MUPTRW5ITVJ?
MEL-HO MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nBRWlEPTB;MD6wNlM1QCEQvF2= MXXTRW5ITVJ?
MC-CAR NVvtWVMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEKzOVYh|ryP M2PBb3NCVkeHUh?=
HSC-2 NIPtRm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX0TWM2OD1yLkCyOFY3KM7:TR?= NH7mRmlUSU6JRWK=
MEL-JUSO MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHWWVFKSzVyPUCuNFI1PzNizszN MYjTRW5ITVJ?
CAL-62 NU\DWGRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljyTWM2OD1yLkCyOlAzKM7:TR?= NU\DfJZJW0GQR1XS
DMS-273 NWTnZ4RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jZNWlEPTB;MD6wNlg1PyEQvF2= NV3LTHN2W0GQR1XS
S-117 NVzje2FbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr6XlVKSzVyPUCuNFI6ODZizszN MnzGV2FPT0WU
SUP-T1 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK5Z2tKSzVyPUCuNFI6PDlizszN NIX3fYxUSU6JRWK=
MZ2-MEL M1S3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;DeGlEPTB;MD6wNlk2QSEQvF2= M3zDTnNCVkeHUh?=
KYSE-270 M3XQS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Ph[WlEPTB;MD6wNlk4PiEQvF2= NWn2dndMW0GQR1XS
CMK MlfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDoNW1KSzVyPUCuNFMxOjNizszN MnS2V2FPT0WU
8505C Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMEOwOEDPxE1? MoL1V2FPT0WU
NUGC-3 NG\CdJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LofmlEPTB;MD6wN|A1QCEQvF2= M3HZWnNCVkeHUh?=
A101D MkDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX72PJd1UUN3ME2wMlA{ODV3IN88US=> M37UOnNCVkeHUh?=
G-401 NEjzZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXjSVhKSzVyPUCuNFMxQTNizszN NFz2N4JUSU6JRWK=
OVCAR-8 NICwZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDHUGxKSzVyPUCuNFMyODdizszN NYDhUphQW0GQR1XS
IMR-5 NH72fG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr3NoxKSzVyPUCuNFMzPDRizszN MkfCV2FPT0WU
DoTc2-4510 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPNTWM2OD1yLkCzN|k{KM7:TR?= NVL3bpI1W0GQR1XS
HOS NUS3eIo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TVU2lEPTB;MD6wN|Q4OyEQvF2= M1LiTXNCVkeHUh?=
HEC-1 Mn3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf5[YtKSzVyPUCuNFM3QCEQvF2= MmrlV2FPT0WU
SW756 M2G0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTQTWM2OD1yLkCzPFIyKM7:TR?= MYnTRW5ITVJ?
NCI-H64 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEO4OFIh|ryP M2[y[nNCVkeHUh?=
EW-16 MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\XTWM2OD1yLkCzPVA6KM7:TR?= NEiyS5NUSU6JRWK=
CAL-51 NUGybXRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMESwNFUh|ryP M3HxVHNCVkeHUh?=
KYSE-150 MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\6UZJKSzVyPUCuNFQxOTFizszN M4ixSXNCVkeHUh?=
SW1710 M3LzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:yd3lKSzVyPUCuNFQxOThizszN NFjnOGRUSU6JRWK=
HuP-T4 Mn:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\VNmlEPTB;MD6wOFEyQCEQvF2= NWewb2JWW0GQR1XS
LB373-MEL-D NYjUZYw5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfOZm9KSzVyPUCuNFQzOzJizszN MYPTRW5ITVJ?
EW-13 NULQUWx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMES0NFYh|ryP MlvxV2FPT0WU
HT-29 M3nQTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zDV2lEPTB;MD6wOFQ6KM7:TR?= M4SxPHNCVkeHUh?=
SCC-25 NX7yVpFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj4fZRKSzVyPUCuNFQ1QTRizszN MXjTRW5ITVJ?
REH M3zxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXZUoRqUUN3ME2wMlA1PjN3IN88US=> MX7TRW5ITVJ?
L-363 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX3[XFZUUN3ME2wMlA1Pjd7IN88US=> NEKzV5BUSU6JRWK=
NCI-H1770 NWfJNJNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMES2PVch|ryP NUHZUIRuW0GQR1XS
CHL-1 Mn;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO2eVZKSzVyPUCuNFQ5PTdizszN NFqzbotUSU6JRWK=
ES1 NFjFe5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlWxTWM2OD1yLkC0PFg2KM7:TR?= M3nWXnNCVkeHUh?=
SCC-15 NEnCXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe2WI9RUUN3ME2wMlA1QTB{IN88US=> M2PodnNCVkeHUh?=
MRK-nu-1 NX\tXY06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjPRoNKSzVyPUCuNFQ6OzZizszN MkO5V2FPT0WU
PF-382 NHH0cGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMES5N|kh|ryP MoPPV2FPT0WU
COLO-680N M3W2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\vbZJKUUN3ME2wMlA2ODR5IN88US=> MomzV2FPT0WU
LK-2 NITPU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEWwOlMh|ryP NFjQRY1USU6JRWK=
NCI-H2342 M1P5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LI[WlEPTB;MD6wOVEyPyEQvF2= NGrJcpZUSU6JRWK=
HMV-II MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX5d5FnUUN3ME2wMlA2OjN7IN88US=> MXvTRW5ITVJ?
PC-14 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHxTWM2OD1yLkC1NlUzKM7:TR?= MVzTRW5ITVJ?
COLO-320-HSR NIH1N3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIe4blRKSzVyPUCuNFUzQDlizszN NHXHUIVUSU6JRWK=
697 M2LUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqyUlZKSzVyPUCuNFU{OjNizszN Mni5V2FPT0WU
NEC8 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7nTWM2OD1yLkC1OVkh|ryP NUPuPJVGW0GQR1XS
LCLC-97TM1 NHjYbW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEW1PVQh|ryP M{TKUHNCVkeHUh?=
Daoy NYWybW56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHDTWM2OD1yLkC1OlE3KM7:TR?= Ml[2V2FPT0WU
ETK-1 M3rRO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfBTWM2OD1yLkC1OlczKM7:TR?= MkDzV2FPT0WU
A388 M3vRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHHZWdnUUN3ME2wMlA2Pjl3IN88US=> MX\TRW5ITVJ?
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SK-PN-DW NUG4bWlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfhWJZIUUN3ME2wMlA2PzJ7IN88US=> MoPoV2FPT0WU
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D-542MG NYnR[2tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPHTWM2OD1yLkG2PVg3KM7:TR?= M3zDNnNCVkeHUh?=
EB-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXzTWM2OD1yLkG3N|Eh|ryP M4PtXHNCVkeHUh?=
HCC1143 M3;4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7JTIxJUUN3ME2wMlE4Ozl4IN88US=> MXfTRW5ITVJ?
DJM-1 M33ieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHoc3FKSzVyPUCuNVc1PTFizszN MnjVV2FPT0WU
BT-474 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnmR2pKSzVyPUCuNVc1QDlizszN MUfTRW5ITVJ?
BB65-RCC NFPCXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLQTWM2OD1yLkG3OVQ2KM7:TR?= MnX1V2FPT0WU
NCI-H292 M{S5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMUe2NFEh|ryP NH6wSZJUSU6JRWK=
MKN28 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Dne2lEPTB;MD6xO|Y2OyEQvF2= NH\ydWRUSU6JRWK=
TK10 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fPZ2lEPTB;MD6xO|cxOiEQvF2= MnXFV2FPT0WU
TYK-nu NGnLTFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[zUHN5UUN3ME2wMlE4QTR7IN88US=> NVTYZ3l6W0GQR1XS
8305C NYj3TVNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r2bmlEPTB;MD6xO|k4OSEQvF2= NU\WbJN6W0GQR1XS
MV-4-11 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMUe5O|ch|ryP MYrTRW5ITVJ?
NCI-H522 NG\ZXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rSRmlEPTB;MD6xPFA6PCEQvF2= NVPlZmt6W0GQR1XS
Hs-578-T NFXZSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPjNplKSzVyPUCuNVgzQTJizszN M17aVXNCVkeHUh?=
LCLC-103H NFfrPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOyTHpKSzVyPUCuNVg2OjdizszN M2j4ZnNCVkeHUh?=
MHH-ES-1 NVnLfWFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vLTmlEPTB;MD6xPFYzQSEQvF2= MXLTRW5ITVJ?
NCI-H441 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMUmxOFgh|ryP M2PtcHNCVkeHUh?=
AM-38 M13ONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPUc4NKSzVyPUCuNVkzOjVizszN MkK3V2FPT0WU
SW1783 NWrDdlVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjodm9KSzVyPUCuNVk{ODVizszN NFruenRUSU6JRWK=
SK-HEP-1 NVjhc4U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMUm2N|ch|ryP MWLTRW5ITVJ?
OAW-28 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMkCxO|gh|ryP MmnuV2FPT0WU
TE-15 Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGOwc2VKSzVyPUCuNlAzPTJizszN NWDXZY1nW0GQR1XS
HCE-4 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMkCyPFQh|ryP NHX5SWtUSU6JRWK=
JiyoyeP-2003 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXsVINKSzVyPUCuNlA{OzZizszN M{TRUXNCVkeHUh?=
OVCAR-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMkC2Nlgh|ryP M3r2NHNCVkeHUh?=
SNU-449 M3f3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PvNGlEPTB;MD6yNFc6PyEQvF2= M{nWOXNCVkeHUh?=
SBC-5 NVrJT|V4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3MTWM2OD1yLkKxNlE2KM7:TR?= NUS2b4p[W0GQR1XS
T84 NGXMNJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDiSmpKSzVyPUCuNlEzPDhizszN NEG3VoFUSU6JRWK=
LP-1 NHy0PZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnVfZRKSzVyPUCuNlE{ODJizszN M2XhdXNCVkeHUh?=
MG-63 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPC[3NKSzVyPUCuNlE{QDJizszN MoXwV2FPT0WU
OAW-42 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMkG0O|gh|ryP Mn;2V2FPT0WU
L-540 Moe4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[xTWM2OD1yLkKxOVk5KM7:TR?= NWXScHVGW0GQR1XS
RH-1 M{nBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnwPHpMUUN3ME2wMlIzOjR{IN88US=> NULZWpI2W0GQR1XS
HCT-15 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLyTWM2OD1yLkKyOFg1KM7:TR?= MUHTRW5ITVJ?
OCUB-M M4rnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMkK0PFgh|ryP NFXDNWhUSU6JRWK=
GP5d MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMkK1Nlgh|ryP MlOxV2FPT0WU
NCI-H2030 M1zlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMkK3N|Qh|ryP MV3TRW5ITVJ?
ML-2 NIXUPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX2OYhKSzVyPUCuNlI5QDlizszN MlnJV2FPT0WU
CAL-39 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MortTWM2OD1yLkKyPVM3KM7:TR?= NUW4bmFQW0GQR1XS
MIA-PaCa-2 M1;2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorYTWM2OD1yLkKzNlg4KM7:TR?= M1j3[XNCVkeHUh?=
TE-9 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f1ZmlEPTB;MD6yN|MzKM7:TR?= M{TZVnNCVkeHUh?=
LB2518-MEL NVqzZoI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWexSoRwUUN3ME2wMlI{Ozd{IN88US=> M4TwRXNCVkeHUh?=
DB MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMkO0N|gh|ryP NXnvTFFrW0GQR1XS
NCI-H596 NHPOWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv1Um1KSzVyPUCuNlM2PzFizszN NH\xTZhUSU6JRWK=
SW1990 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjrTWc2UUN3ME2wMlI{QTR4IN88US=> Ml7OV2FPT0WU
P30-OHK Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf0TWM2OD1yLkK0NFUh|ryP M2D0Z3NCVkeHUh?=
ALL-PO MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXyzdnlvUUN3ME2wMlI1OTZ7IN88US=> MXTTRW5ITVJ?
Saos-2 NX7xbVdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjYTWM2OD1yLkK0OVcyKM7:TR?= MYDTRW5ITVJ?
MFH-ino MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDQfmV3UUN3ME2wMlI1Pjl{IN88US=> MkHrV2FPT0WU
OE33 NVzueGc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK3bnNKSzVyPUCuNlUyOSEQvF2= MVjTRW5ITVJ?
Calu-3 NHThXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DiRmlEPTB;MD6yOVI6PyEQvF2= MmDmV2FPT0WU
HT M17SWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMkW2NlEh|ryP MknEV2FPT0WU
LXF-289 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmf0TWM2OD1yLkK1PVg1KM7:TR?= MV7TRW5ITVJ?
KGN MnzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMk[wPFkh|ryP NEfodVVUSU6JRWK=
NCI-H1417 NWnobWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XQR2lEPTB;MD6yOlUzPCEQvF2= MkfJV2FPT0WU
SF126 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMkezNFIh|ryP MWPTRW5ITVJ?
SAS NFrsdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMkezNFgh|ryP M1f2OXNCVkeHUh?=
22RV1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMkezO|gh|ryP M2HsdHNCVkeHUh?=
GI-1 NE[1cYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMke0PFch|ryP NHi3V2xUSU6JRWK=
ES3 NYL5W5N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHaUGl[UUN3ME2wMlI4PzZ|IN88US=> NE\adolUSU6JRWK=
NB1 Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjWTWM2OD1yLkK3PFc3KM7:TR?= Mn\lV2FPT0WU
NCI-H650 NVWwfpQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfMTWM2OD1yLkK4N|AzKM7:TR?= MonJV2FPT0WU
IST-MES1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PJTGlEPTB;MD6yPFU2PCEQvF2= M4O1RXNCVkeHUh?=
UM-UC-3 NHz1SWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13CSmlEPTB;MD6yPVE1KM7:TR?= NFfqdVVUSU6JRWK=
CAL-120 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\hW3FuUUN3ME2wMlI6PjNzIN88US=> MnPHV2FPT0WU
UACC-62 M3\pVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnFXJE4UUN3ME2wMlMxOjRzIN88US=> NFnlT3dUSU6JRWK=
TE-11 NELrSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnnbmNzUUN3ME2wMlMxOjR7IN88US=> NGnDSWFUSU6JRWK=
MKN1 M2fBbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTBwM{CzOkDPxE1? NED6NHRUSU6JRWK=
KS-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwM{C1NlYh|ryP MkHhV2FPT0WU
GCIY MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwM{GwNFIh|ryP NH7hVJRUSU6JRWK=
OVCAR-5 NH3y[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2yTWM2OD1yLkOxNVA3KM7:TR?= MYnTRW5ITVJ?
U-266 NHrlPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jKfGlEPTB;MD6zNVE1PyEQvF2= MoPoV2FPT0WU
Calu-1 Mn7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi4TWM2OD1yLkOxNlg6KM7:TR?= M4C1TnNCVkeHUh?=
SK-LMS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXuTWM2OD1yLkOxOFI6KM7:TR?= MWDTRW5ITVJ?
COLO-741 NV7UUFh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi1SGlxUUN3ME2wMlMyPjF2IN88US=> MXXTRW5ITVJ?
RPMI-8226 NYHEfpc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL4O3ZKSzVyPUCuN|E3PDFizszN MnfmV2FPT0WU
KM12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PrOGlEPTB;MD6zNVg{KM7:TR?= NYPtUmF3W0GQR1XS
NMC-G1 NHLJ[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLzTWM2OD1yLkOxPFYh|ryP NWjlb2tJW0GQR1XS
SJRH30 NYjwS3NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLwd3pPUUN3ME2wMlMzODV{IN88US=> M4\CWHNCVkeHUh?=
COR-L105 NYG4XXllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwM{KyNVgh|ryP NXXqfI5IW0GQR1XS
IM-9 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPDNGdKSzVyPUCuN|MxOjFizszN M4KxWHNCVkeHUh?=
TE-12 NF\LU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki5TWM2OD1yLkOzN|E4KM7:TR?= NYXtUHZvW0GQR1XS
KG-1 NV7KPGtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XPRmlEPTB;MD6zN|Q{OiEQvF2= MVHTRW5ITVJ?
U251 MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jSUWlEPTB;MD6zN|Q2PiEQvF2= MWnTRW5ITVJ?
EFO-27 NVTSW2NMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTtVWd1UUN3ME2wMlM{QTVzIN88US=> NH7qSJhUSU6JRWK=
EW-24 NHvPNm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XsUmlEPTB;MD6zN|k5PCEQvF2= MnXDV2FPT0WU
SF295 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTYZY5KSzVyPUCuN|M6QTlizszN NV[xPYNqW0GQR1XS
MC-IXC NH;Id|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nNVWlEPTB;MD6zOFUh|ryP M3qw[HNCVkeHUh?=
NCI-H2405 NXLxNZVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK5WlJKUUN3ME2wMlM1PzN{IN88US=> MYXTRW5ITVJ?
NCI-H2009 M17rNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjFTWM2OD1yLkO0O|M6KM7:TR?= MnLZV2FPT0WU
LB1047-RCC M4jTSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vUdWlEPTB;MD6zOVgyPSEQvF2= MUPTRW5ITVJ?
KNS-81-FD MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwM{[2Olch|ryP MkD0V2FPT0WU
HOP-92 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\kTWM2OD1yLkO2PFMh|ryP NGH3Rm1USU6JRWK=
L-428 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\BTWM2OD1yLkO3NFE3KM7:TR?= M2rLSXNCVkeHUh?=
C3A NHPmWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwM{ezO|kh|ryP M17L[HNCVkeHUh?=
NCI-H1792 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XNZWlEPTB;MD6zO|Y2PSEQvF2= NWHqcGhKW0GQR1XS
HuH-7 NHjhO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwM{e5NUDPxE1? MmHIV2FPT0WU
AGS NWrM[2RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\MV2lEPTB;MD6zPFY{QCEQvF2= MUHTRW5ITVJ?
HT-1197 NXu0[mJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn5TZVMUUN3ME2wMlM6PDZizszN NFiz[YlUSU6JRWK=
CGTH-W-1 NUW1S41IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwM{m5NVMh|ryP MkXpV2FPT0WU
KNS-42 M160Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwNECwOFUh|ryP NYWyN2NwW0GQR1XS
HuO-3N1 NVf1ZVZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwNECwOVUh|ryP NI\UPYhUSU6JRWK=
VMRC-RCZ NV75WnhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzXTWM2OD1yLkSwN|A{KM7:TR?= MlPUV2FPT0WU
SW954 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwNECzN|Uh|ryP NUHhPJdlW0GQR1XS
MES-SA M3Kyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn31TWM2OD1yLkSwOVA2KM7:TR?= M4TnRXNCVkeHUh?=
Ca-Ski MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUWzUZN6UUN3ME2wMlQxPTJ2IN88US=> MVPTRW5ITVJ?
SW13 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\oTGlEPTB;MD60NFYzPiEQvF2= NXTIdlRzW0GQR1XS
NCI-H1437 M4nQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnBTWtKSzVyPUCuOFA5ODVizszN MV3TRW5ITVJ?
U-118-MG NVrKeJpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLKdZoyUUN3ME2wMlQxQTB2IN88US=> NX\RVVRMW0GQR1XS
NCI-H1734 NXvVUWNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHHc4hLUUN3ME2wMlQzODF|IN88US=> MVvTRW5ITVJ?
HDLM-2 M3jscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwNEKwN|Mh|ryP M2i5bHNCVkeHUh?=
AU565 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PFcWlEPTB;MD60NlQ3QCEQvF2= NY\INnpUW0GQR1XS
FADU MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[xbWlEPTB;MD60NlY1QSEQvF2= M3zsWXNCVkeHUh?=
OS-RC-2 NGrje3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13VbWlEPTB;MD60N|A5OyEQvF2= MWLTRW5ITVJ?
CAMA-1 NW\ZfYdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTx[JE1UUN3ME2wMlQ{PjJ4IN88US=> M2[5Z3NCVkeHUh?=
MONO-MAC-6 Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\2XIJEUUN3ME2wMlQ{QDR7IN88US=> MWrTRW5ITVJ?
LB831-BLC M134bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fqOGlEPTB;MD60OFM4OSEQvF2= NITsXGhUSU6JRWK=
SW982 NUfqWld2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H2Z2lEPTB;MD60OFUzQCEQvF2= NGXnVWlUSU6JRWK=
SCC-3 NGXSb|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LwV2lEPTB;MD60OFU4QSEQvF2= M1zVfHNCVkeHUh?=
C32 M{D0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHCWnZKSzVyPUCuOFUzOjlizszN MUfTRW5ITVJ?
BFTC-909 M1HPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i1bWlEPTB;MD60OVI6QSEQvF2= M1TwWXNCVkeHUh?=
MEG-01 M1jVTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nNTWlEPTB;MD60OVM4OyEQvF2= MVHTRW5ITVJ?
M14 MnvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mne2TWM2OD1yLkS1PVc6KM7:TR?= MkL5V2FPT0WU
MPP-89 M2ixbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTINpJKSzVyPUCuOFYzPTZizszN Mk\UV2FPT0WU
HCC1937 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfPSoZZUUN3ME2wMlQ3Ozh2IN88US=> M2T2Z3NCVkeHUh?=
SW837 NGPpOHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;OfmxKSzVyPUCuOFY4OjJizszN MkG3V2FPT0WU
DU-145 MmHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNE[3Nlkh|ryP NXzPNFhEW0GQR1XS
LB996-RCC MoLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH3[YplUUN3ME2wMlQ4ODV2IN88US=> NELkeGtUSU6JRWK=
C8166 NVrBdW0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjveopKSzVyPUCuOFc1KM7:TR?= MXrTRW5ITVJ?
MOLT-4 MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwNEe3N|Qh|ryP NFTGbY1USU6JRWK=
DMS-53 NX\MWZVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HNe2lEPTB;MD60O|gxQSEQvF2= Ml71V2FPT0WU
TE-5 M3\4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nn[GlEPTB;MD60PFMxPSEQvF2= M4D3R3NCVkeHUh?=
KYSE-520 M{fyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvubFVKSzVyPUCuOFg{PDNizszN NXrlWJlMW0GQR1XS
Detroit562 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlviTWM2OD1yLkS4PFYh|ryP MVvTRW5ITVJ?
SIMA MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe0b3JHUUN3ME2wMlQ6PDF5IN88US=> MVXTRW5ITVJ?
NCI-H1651 MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNEm2O{DPxE1? NX35OHMxW0GQR1XS
HCC1599 Mm\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\wW25oUUN3ME2wMlQ6QTV3IN88US=> NVP2dHI{W0GQR1XS
ABC-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv5b5NKSzVyPUCuOVA1QTZizszN MYTTRW5ITVJ?
CAL-33 NFryTI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS0O|RSUUN3ME2wMlUxQDR2IN88US=> NUf2WIFGW0GQR1XS
OPM-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNUC5N|ch|ryP NYm3So0{W0GQR1XS
RPMI-7951 NFu4OnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDmTWM2OD1yLkWwPVU4KM7:TR?= NWr4dGNRW0GQR1XS
HT-1080 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTBTWM2OD1yLkWxNVE6KM7:TR?= NG\6VHZUSU6JRWK=
LC4-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPtXmhKSzVyPUCuOVE1ODNizszN M3[5TnNCVkeHUh?=
OVCAR-3 MnHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\6[ng{UUN3ME2wMlUyPTdizszN NV[4O5V[W0GQR1XS
CAPAN-1 NEjiUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjTVY9KSzVyPUCuOVIzQDhizszN MorJV2FPT0WU
SK-OV-3 M2O3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXuNHVrUUN3ME2wMlUzPDN2IN88US=> NHHsXnhUSU6JRWK=
HuP-T3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorSTWM2OD1yLkWyPFI4KM7:TR?= NHHBS|hUSU6JRWK=
NCI-H838 MnXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwNUK4OFkh|ryP M3Pn[nNCVkeHUh?=
K5 M36wVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNUOyNFEh|ryP NGC1OYdUSU6JRWK=
CAL-72 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XFWGlEPTB;MD61N|M5PyEQvF2= MVjTRW5ITVJ?
NH-12 M3frXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jkfGlEPTB;MD61N|k2QSEQvF2= M3i3U3NCVkeHUh?=
SNB75 M4f6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;ORmlEPTB;MD61OVc{KM7:TR?= M4LQOnNCVkeHUh?=
BPH-1 NU\WWHhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3oPXBtUUN3ME2wMlU3OzR2IN88US=> MVjTRW5ITVJ?
NOMO-1 NVXTZncxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvZemRKSzVyPUCuOVY{PzJizszN NVfYcmsxW0GQR1XS
G-402 M13mbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTWVIFKSzVyPUCuOVY1QTlizszN NFzl[I9USU6JRWK=
NCI-H2052 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vXfmlEPTB;MD61Olc1OSEQvF2= M4j5fXNCVkeHUh?=
RCM-1 NVPzVXU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwNUexOlYh|ryP NGXMUYxUSU6JRWK=
COR-L279 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW3UmNKSzVyPUCuOVcyQDVizszN M13UfnNCVkeHUh?=
A253 MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwNUe1NlUh|ryP M4[xVnNCVkeHUh?=
SK-MM-2 NHHaR5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPBTWM2OD1yLkW3Olc6KM7:TR?= MYLTRW5ITVJ?
NCI-H1703 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzQTWM2OD1yLkW5OFI4KM7:TR?= MX;TRW5ITVJ?
UACC-257 M1;oOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTBwNUm0PFch|ryP MV;TRW5ITVJ?
KALS-1 M4rSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW0eGw2UUN3ME2wMlYxODFzIN88US=> M2\pdHNCVkeHUh?=
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MHH-CALL-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDScI56UUN3ME2wMlYxQDh6IN88US=> MYLTRW5ITVJ?
ChaGo-K-1 M1vkUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rHNWlEPTB;MD62NVIzQSEQvF2= Ml\QV2FPT0WU
TGBC1TKB Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTTUIdKSzVyPUCuOlE6QCEQvF2= MVrTRW5ITVJ?
KU-19-19 NHX1eo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvUTWM2OD1yLk[0OVg3KM7:TR?= NIfSb5BUSU6JRWK=
COLO-684 MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD4dGxMUUN3ME2wMlY2PjFzIN88US=> M4nVXHNCVkeHUh?=
LS-1034 NIfPZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3kcpllUUN3ME2wMlY2QDF7IN88US=> NEfZZYdUSU6JRWK=
RT-112 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLTTWM2OD1yLk[2OVg4KM7:TR?= NGLKdnRUSU6JRWK=
Capan-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LqRmlEPTB;MD62OlYzOiEQvF2= MUjTRW5ITVJ?
HSC-4 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojXTWM2OD1yLk[2Olk5KM7:TR?= NX\y[VBDW0GQR1XS
COLO-824 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLB[Xd5UUN3ME2wMlY4QDJ|IN88US=> M1XxUHNCVkeHUh?=
NCI-H2170 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLsell[UUN3ME2wMlY5OjV6IN88US=> MWXTRW5ITVJ?
GDM-1 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvwTWM2OD1yLk[4OFk1KM7:TR?= NHX1V4NUSU6JRWK=
KP-4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEexbHJKSzVyPUCuOlk2PzNizszN MofCV2FPT0WU
VA-ES-BJ MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfGXYRQUUN3ME2wMlY6QTh4IN88US=> NHLiZpJUSU6JRWK=
KM-H2 NUL3bHZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHqeYxKSzVyPUCuO|AxQTFizszN NHLMT5RUSU6JRWK=
HH NInmUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zPPGlEPTB;MD63NFY3OiEQvF2= M1L4fHNCVkeHUh?=
DK-MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LJWGlEPTB;MD63NVAyPiEQvF2= M1vsN3NCVkeHUh?=
VM-CUB-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjJXVVKSzVyPUCuO|EzPTlizszN MnLFV2FPT0WU
COLO-829 NGWwT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDtTWM2OD1yLkexPVg2KM7:TR?= NHrWN|JUSU6JRWK=
OMC-1 M4nDNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fiN2lEPTB;MD63NlExPCEQvF2= MnXkV2FPT0WU
NB12 MnHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwN{K1NFQh|ryP MWXTRW5ITVJ?
NCI-H28 M13mUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TTNWlEPTB;MD63OFA5OyEQvF2= NIHzOVFUSU6JRWK=
A673 NEXHR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;aemlEPTB;MD63OVE4PyEQvF2= MmfKV2FPT0WU
LB2241-RCC MljQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LjVGlEPTB;MD63OlA5PyEQvF2= NInTVG5USU6JRWK=
CCRF-CEM NX33RnI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInCOVdKSzVyPUCuO|cxPTJizszN MmHsV2FPT0WU
NCI-H510A NYTnfFRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2P0OGlEPTB;MD63O|E5PiEQvF2= MnnzV2FPT0WU
SW48 M4rBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7RTWM2OD1yLke3N|M{KM7:TR?= MVfTRW5ITVJ?
NCI-H2081 M33kRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7xUI9KSzVyPUCuO|gyPDdizszN M372UXNCVkeHUh?=
RMG-I NYXXbnk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP3eFhKSzVyPUCuO|gzOTJizszN MoO1V2FPT0WU
LU-99A MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwN{i0NVMh|ryP Mli2V2FPT0WU
KP-N-YS M4fKNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwN{i5NlEh|ryP NYfZVXBkW0GQR1XS
MDA-MB-231 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrzdmhKSzVyPUCuPFAyOzFizszN MmDPV2FPT0WU
U031 M4fsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPtWZJKSzVyPUCuPFE1OjNizszN NV21Zpc2W0GQR1XS
EVSA-T NGizfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzJTWM2OD1yLkixOlczKM7:TR?= NXGyS4xMW0GQR1XS
MDA-MB-157 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwOEKyO|Eh|ryP NGHlS|ZUSU6JRWK=
EHEB NVXHUGV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjBTWM2OD1yLkiyNlc3KM7:TR?= NX\tRoxbW0GQR1XS
KINGS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[xfWh2UUN3ME2wMlgzPTV3IN88US=> MnfuV2FPT0WU
23132-87 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwOEK4OFMh|ryP M{DMdXNCVkeHUh?=
EFO-21 NH;3eoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rYfmlEPTB;MD64OFA5QSEQvF2= MmX2V2FPT0WU
DOK NEDsT5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSyTWM2OD1yLki0PEDPxE1? NW\LbXhIW0GQR1XS
NCI-H2171 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjnepVCUUN3ME2wMlg1QTZizszN NXXoNXg1W0GQR1XS
NCI-SNU-5 NWW0Oow1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jqdGlEPTB;MD64OVU4KM7:TR?= MXPTRW5ITVJ?
SK-N-DZ NWmzXog6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\OZndRUUN3ME2wMlg2QTR|IN88US=> Ml:5V2FPT0WU
SNU-C2B NIjtfJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvuTWM2OD1yLki2PFAyKM7:TR?= NE\hTWhUSU6JRWK=
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SN12C MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfQc3lKSzVyPUCuPFg3OzdizszN NWfnfYdsW0GQR1XS
A172 NGLZb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nnOWlEPTB;MD64PFY6QCEQvF2= Mn;WV2FPT0WU
NCI-H2347 NX;lVG1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwOEi3OVMh|ryP NIjqbJZUSU6JRWK=
NCI-H2228 NHTwZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDuSI1bUUN3ME2wMlg6OzN7IN88US=> MXjTRW5ITVJ?
SNU-387 M1zEXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTU[|U4UUN3ME2wMlkxOjZ2IN88US=> NYPTcVh5W0GQR1XS
SK-MEL-24 M2Dsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r3[mlEPTB;MD65NVM1PCEQvF2= NULhNINkW0GQR1XS
MDA-MB-468 NIi1SXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwOUG3N{DPxE1? NFv1dWRUSU6JRWK=
NCI-H1694 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXnUoxKSzVyPUCuPVE5PzZizszN NIjiNmhUSU6JRWK=
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K052 M4PmZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PDbGlEPTB;MD65OFA1PyEQvF2= MVfTRW5ITVJ?
NCI-H446 M{nlTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO3cXpKSzVyPUCuPVUxOSEQvF2= NIDvO4dUSU6JRWK=
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KU812 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXkT3ZKSzVyPUCuPVk{QDlizszN NYTSUWc1W0GQR1XS
MDA-MB-361 NY\OSWRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3noTWlEPTB;MD65PVc4PyEQvF2= NXvlPXdLW0GQR1XS
Raji MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFwMEKyOlch|ryP MVnTRW5ITVJ?
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CAL-148 MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37qR2lEPTB;MT6wOFQ1OyEQvF2= NVTUUpN[W0GQR1XS
NCI-H1963 M4raXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHL[HlKSzVyPUGuNFQ2PTNizszN MofXV2FPT0WU
SK-N-AS NYXWZWZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jQPGlEPTB;MT6wOFY5PSEQvF2= NFvPV5JUSU6JRWK=
RERF-LC-MS MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rZeGlEPTB;MT6wOlM1QSEQvF2= M1:yUHNCVkeHUh?=
BEN MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrYb2VKSzVyPUGuNFcyOzdizszN Mo\nV2FPT0WU
CAS-1 NFPR[Y9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;yRWpPUUN3ME2xMlA6OTJ|IN88US=> NVnsV5g1W0GQR1XS
SW780 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGr2RohKSzVyPUGuNFkyQDFizszN M1rUdHNCVkeHUh?=
LU-65 NH72VVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnFbYFKSzVyPUGuNFk1OSEQvF2= MWjTRW5ITVJ?
D-283MED NWXnXpNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DkPWlEPTB;MT6xNlI4OiEQvF2= MlLuV2FPT0WU
HCC2157 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv1cY1KSzVyPUGuNVM3PDJizszN NH7tVpFUSU6JRWK=
RCC10RGB NIXhNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv5UmVKSzVyPUGuNVQxODZizszN NUjTdnR4W0GQR1XS
PLC-PRF-5 M4G2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEToV2RKSzVyPUGuNVUzOjlizszN NXrOW4NHW0GQR1XS
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TUR M1GzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\jTWM2OD1zLkG1O|UzKM7:TR?= NIDxVGxUSU6JRWK=
NCI-H2141 NWrB[G4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPwcHFDUUN3ME2xMlE5QTR4IN88US=> MVnTRW5ITVJ?
PFSK-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfnTWM2OD1zLkKwOVMzKM7:TR?= M3\tWnNCVkeHUh?=
SK-MEL-28 M1\aZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTFwMkOyNlEh|ryP NWe5Zm1wW0GQR1XS
SCC-9 M1Wxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnQd2ZFUUN3ME2xMlI{PjZ3IN88US=> NE\HWmVUSU6JRWK=
T47D MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwMkO2PVYh|ryP M{HpcnNCVkeHUh?=
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HCC1954 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvsTWM2OD13Lki1PVcyKM7:TR?= Mlj6V2FPT0WU
NCI-H187 M{fzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrqNnFyUUN3ME21MlkzQTh7IN88US=> NWe5NGNCW0GQR1XS
LU-165 M{HJTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r4WmlEPTB;NT65PVAxOiEQvF2= M1nMbXNCVkeHUh?=
YAPC M2qxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHPTWM2OD13Lkm5NFY5KM7:TR?= NWPYS3QxW0GQR1XS
LU-139 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq2fHBKSzVyPU[uNFg{PjhizszN NFu3XIlUSU6JRWK=
D-502MG M3X3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2mzTGlEPTB;Nj6zNlA1PyEQvF2= NWPXc|RIW0GQR1XS
IST-SL1 M1W1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu4TWM2OD14LkWzPVQ5KM7:TR?= NUH2OJFVW0GQR1XS
DG-75 MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HYe2lEPTB;Nj64PFc5PiEQvF2= Mme0V2FPT0WU
NCI-H1155 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTZwOUW1PFEh|ryP MlSwV2FPT0WU
EFE-184 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPNUmp5UUN3ME23MlMyPjl3IN88US=> MYPTRW5ITVJ?
AsPC-1 NGHkVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jxSGlEPTB;Nz60PFgxPyEQvF2= NGruV3ZUSU6JRWK=
SW948 M4KxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PFeGlEPTB;Nz61PFM6PSEQvF2= NVzFb|ZiW0GQR1XS
NCI-H524 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXIUoM3UUN3ME25MlU5PjJ6IN88US=> MYXTRW5ITVJ?
KOSC-2 NYHtOIxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHpTWM2OD17Lk[yPFM1KM7:TR?= MnzmV2FPT0WU
T-24 NXK1VVA{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4f3OWlEPTB;OT65OFQyPSEQvF2= NGLtU|FUSU6JRWK=
NCI-H748 NUK0VYdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PXemlEPTB;MUCuOlM6PyEQvF2= NV7sNYh5W0GQR1XS
NCI-H23 NWTGS|VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfqOpJ6UUN3ME2xNE43PDR{IN88US=> MkfMV2FPT0WU
UACC-812 NULPZZB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFzLkexO{DPxE1? NEPnboRUSU6JRWK=
SCLC-21H MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF{LkG1OVEh|ryP NIr2SnNUSU6JRWK=
NCI-SNU-16 MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF|LkGyOVgh|ryP M{PCN3NCVkeHUh?=
HD-MY-Z NVn0U|JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC3TWM2OD1zND62N|Y{KM7:TR?= NITHOZpUSU6JRWK=
SK-N-FI NUf2RVJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrxTWM2OD1zND64PVEzKM7:TR?= MnfXV2FPT0WU
LB647-SCLC MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLjTWM2OD1zNT63NVk2KM7:TR?= MmjEV2FPT0WU
NCI-H345 NEPZeJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LCTmlEPTB;MUeuN|Q{KM7:TR?= NWHGd2hOW0GQR1XS
NCI-H1563 NFTyZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHuTWM2OD1zOD63OlAyKM7:TR?= MUXTRW5ITVJ?
RL M4jTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofpTWM2OD1{MT6yOlU3KM7:TR?= M4jIRnNCVkeHUh?=
KY821 NHrPeoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjqNIJCUUN3ME2yNk4xPTV|IN88US=> MV7TRW5ITVJ?
JVM-3 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnFcmZKSzVyPUK1MlA1OTNizszN NYrqPIp[W0GQR1XS
NCI-H1793 NEW0fHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{S0OGlEPTB;MkiuOVQ6QSEQvF2= NEH4dpRUSU6JRWK=
LU-134-A NEC0bIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;WTWM2OD1|MD6yNFM4KM7:TR?= NFrjPWdUSU6JRWK=
NCI-H1395 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnVW5lKSzVyPUOyMlI1OzFizszN MYnTRW5ITVJ?
NCI-H1993 NEOyNJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fCbmlEPTB;M{KuPFIyQCEQvF2= M1H0fnNCVkeHUh?=
P31-FUJ M3K0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXK[5VKSzVyPUOzMlQ5QTlizszN M4PwNnNCVkeHUh?=
LS-513 MknnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnewTWM2OD1|NT64PFc6KM7:TR?= Mk\HV2FPT0WU
SK-MEL-1 NH;GVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\rTnhpUUN3ME20NE4{PDl7IN88US=> MlfmV2FPT0WU
SW684 MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTR|Lkm2OlEh|ryP NUTOWG9UW0GQR1XS
COR-L88 NYLpfnJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHOUlBKSzVyPUS0MlA3PjVizszN M1fXZnNCVkeHUh?=
NCI-H889 NIfYOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLGcIFUUUN3ME20OU4xODh5IN88US=> M3m2b3NCVkeHUh?=
TALL-1 NVfLPYliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvzTWM2OD12Nj6xNVk6KM7:TR?= MlLBV2FPT0WU
KARPAS-299 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISxfHdKSzVyPUS3MlE6QTNizszN MlW3V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin D1 / p27 Kip1 ; 

PubMed: 28382170     


Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1.

p-Cyclin D1 ; 

PubMed: 28035994     


Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control;

p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; 

PubMed: 28035994     


Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;

28382170 28035994
Growth inhibition assay
Cell proliferation ; 

PubMed: 28035994     


Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control.

Cell viability; 

PubMed: 21368880     


H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D. 

28035994 21368880
In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
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Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
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  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A
Smiles COC\1=CC(=NC1=C\C2=C(C)C=C(C)[NH]2)C3=CC4=CC=CC=C4[NH]3.C[S](O)(=O)=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID