Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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In DMSO USD 190 In stock
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9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell Death Dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 M1z2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vlSWlEPTB;MD6wNFAxOzF5IN88US=> M1T6SXNCVkeHUh?=
SK-MEL-30 MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\r[Zd1UUN3ME2wMlAxODN3NTFOwG0> MnLoV2FPT0WU
NALM-6 NVnj[5lvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW[yNodHUUN3ME2wMlAxODN3NjFOwG0> MmnWV2FPT0WU
KYSE-450 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jFcmlEPTB;MD6wNFA1PjlizszN NUjZNpk4W0GQR1XS
BHY Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTBeHIyUUN3ME2wMlAxODZyMTFOwG0> MlflV2FPT0WU
GR-ST NFzPTlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMECwOlQ5KM7:TR?= Mnn5V2FPT0WU
786-0 NF3CT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;vXWlEPTB;MD6wNFA4PzZizszN NEC1bpNUSU6JRWK=
C-33-A MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrUfJpKSzVyPUCuNFAxQDR6IN88US=> NXfNO5JEW0GQR1XS
BHT-101 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMECxNFYh|ryP NUXte2d7W0GQR1XS
EB2 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr0U|k2UUN3ME2wMlAxOTF6IN88US=> MnXnV2FPT0WU
G-361 NXnrdWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnqwTWM2OD1yLkCwNVI1KM7:TR?= MmHoV2FPT0WU
KE-37 NY[x[YFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn4PYpUUUN3ME2wMlAxOTJ6IN88US=> MXrTRW5ITVJ?
MHH-PREB-1 M33pfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPHRnJwUUN3ME2wMlAxOTRizszN MWLTRW5ITVJ?
MCF7 NV;TZnZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMECxOVkh|ryP M4r1WnNCVkeHUh?=
LOUCY NUTFVGZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwMECxO|Uh|ryP M{\vOXNCVkeHUh?=
EW-7 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrpW3R1UUN3ME2wMlAxOTd3IN88US=> M1jFS3NCVkeHUh?=
KYSE-510 M3zy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\tTWM2OD1yLkCwNlM{KM7:TR?= M3H4RnNCVkeHUh?=
SK-MEL-3 NUC2VW1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHnNoxyUUN3ME2wMlAxOjZ2IN88US=> MYDTRW5ITVJ?
HAL-01 M1;uNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\C[2lEPTB;MD6wNFI6PyEQvF2= NIO2VZdUSU6JRWK=
HCC2998 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMECzN|Uh|ryP NHfUUG5USU6JRWK=
A375 NIfVbpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\rTWM2OD1yLkCwN|Uh|ryP NF3YdHFUSU6JRWK=
MZ7-mel MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3T1cGlEPTB;MD6wNFM6QSEQvF2= NF:y[ldUSU6JRWK=
SH-4 M3XLV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjkTWM2OD1yLkCwOFE4KM7:TR?= NYLKPVFZW0GQR1XS
HT-144 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXQTWM2OD1yLkCwOFMh|ryP NWrITI1sW0GQR1XS
KYSE-140 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;lTWM2OD1yLkCwOFM2KM7:TR?= M{jqZXNCVkeHUh?=
PSN1 NFz5UppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3NTHRJUUN3ME2wMlAxPDZ5IN88US=> NHTwO5hUSU6JRWK=
COLO-679 NHO3T3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTSZ2lzUUN3ME2wMlAxPDl6IN88US=> M3viRnNCVkeHUh?=
SW620 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrST2NKSzVyPUCuNFA2OTFizszN MoSyV2FPT0WU
HGC-27 Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\VdZl2UUN3ME2wMlAxPTJ2IN88US=> NIjve3NUSU6JRWK=
IGROV-1 M2L5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ThSGlEPTB;MD6wNFYh|ryP NUWyU|BlW0GQR1XS
IGR-1 NEf2NJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzGTol4UUN3ME2wMlAxPjBzIN88US=> MV\TRW5ITVJ?
EW-1 M{foOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEC2OVEh|ryP M3\OOHNCVkeHUh?=
769-P MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEC2O|gh|ryP NEH5c2lUSU6JRWK=
HN MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvHW4FXUUN3ME2wMlAxPjd7IN88US=> NWTDTI5lW0GQR1XS
SIG-M5 M2\vbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEC3NUDPxE1? MmrtV2FPT0WU
IST-MEL1 NGD1SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOxV2lKSzVyPUCuNFA5OThizszN NFT1d|BUSU6JRWK=
ST486 NELHVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj5TWM2OD1yLkCwPFI2KM7:TR?= MV3TRW5ITVJ?
ES7 NWnWTHZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzte|NKSzVyPUCuNFA5PDZizszN NV7LOYNZW0GQR1XS
GAK MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzBTWM2OD1yLkCwPFQ5KM7:TR?= M3rxeHNCVkeHUh?=
BB30-HNC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonpTWM2OD1yLkCwPFU5KM7:TR?= M2jIcXNCVkeHUh?=
IPC-298 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfnWoFKSzVyPUCuNFA6OjdizszN MmPiV2FPT0WU
NKM-1 M{izT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f4bGlEPTB;MD6wNFk4OiEQvF2= MonJV2FPT0WU
RKO NEDsOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETyUJRKSzVyPUCuNFExPDRizszN NEXNRlJUSU6JRWK=
ACN Mlq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{SxSmlEPTB;MD6wNVE{OSEQvF2= NFf0TVVUSU6JRWK=
SW1417 NFPHVFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELHXXlKSzVyPUCuNFEzOjVizszN Ml3sV2FPT0WU
SR NUnQToJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPlTWM2OD1yLkCxNlM2KM7:TR?= MYLTRW5ITVJ?
SNG-M NGPyeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojwTWM2OD1yLkCxN|E4KM7:TR?= NEHKNldUSU6JRWK=
CAL-12T NUeyNoRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLMdYRKSzVyPUCuNFE{PDZizszN M{XOZnNCVkeHUh?=
HSC-3 NX;IfYdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HWZ2lEPTB;MD6wNVM2PSEQvF2= MonZV2FPT0WU
DOHH-2 NXfTOnVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEG0NVIh|ryP M3X5[3NCVkeHUh?=
NB69 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TyUGlEPTB;MD6wNVU3PSEQvF2= MVPTRW5ITVJ?
LC-2-ad M1TNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\WWHhKSzVyPUCuNFE2QDFizszN M3;uTXNCVkeHUh?=
RVH-421 NXLHWlFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TnXWlEPTB;MD6wNVY4PCEQvF2= NHPRVo1USU6JRWK=
TGW MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3wcGFXUUN3ME2wMlAyPzN7IN88US=> MmjwV2FPT0WU
HCC1569 NVXaO|VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfyTWtKUUN3ME2wMlAyPzl5IN88US=> M2fEb3NCVkeHUh?=
CAL-85-1 NWjZOFV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LlPGlEPTB;MD6wNVg{OiEQvF2= MorxV2FPT0WU
RPMI-8402 M3jV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDObFNKSzVyPUCuNFE5PThizszN NFfNTJJUSU6JRWK=
THP-1 M2DFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG3T2I4UUN3ME2wMlAyQTl6IN88US=> MXXTRW5ITVJ?
ONS-76 M2\3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rBbGlEPTB;MD6wNlA{PiEQvF2= NUfFXINQW0GQR1XS
A2780 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvhTWM2OD1yLkCyNFc6KM7:TR?= NHO0Xm1USU6JRWK=
RPMI-2650 M1rrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEKyPVYh|ryP M{nRRXNCVkeHUh?=
MEL-HO M13OW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3XTWM2OD1yLkCyN|Q5KM7:TR?= MWTTRW5ITVJ?
MC-CAR MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DTNWlEPTB;MD6wNlM2PiEQvF2= NVvIRZpSW0GQR1XS
HSC-2 NX\wXZNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\zSGlEPTB;MD6wNlQ3PiEQvF2= NFXvZ5lUSU6JRWK=
MEL-JUSO MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn1TWM2OD1yLkCyOFc{KM7:TR?= NXrXTnRXW0GQR1XS
CAL-62 NXvxeHMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEK2NFIh|ryP NWD6UWVJW0GQR1XS
DMS-273 NGjt[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe3d|VKSzVyPUCuNFI5PDdizszN NXi0OWNQW0GQR1XS
S-117 NUDNcZdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHvTWM2OD1yLkCyPVA3KM7:TR?= NWqxeVUxW0GQR1XS
SUP-T1 NGT5VGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TtS2lEPTB;MD6wNlk1QSEQvF2= NVP4[WdVW0GQR1XS
MZ2-MEL MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrXXGtHUUN3ME2wMlAzQTV7IN88US=> NYfxdoxsW0GQR1XS
KYSE-270 NFTUV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvCTWM2OD1yLkCyPVc3KM7:TR?= NHX2cWhUSU6JRWK=
CMK M1XHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPWU48xUUN3ME2wMlA{ODJ|IN88US=> M{CwXnNCVkeHUh?=
8505C MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD2O|RQUUN3ME2wMlA{ODRizszN NF\VUXpUSU6JRWK=
NUGC-3 NXTr[VhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT3bG5NUUN3ME2wMlA{ODR6IN88US=> NFjMTmNUSU6JRWK=
A101D M3PsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXMTWM2OD1yLkCzNFU2KM7:TR?= NVPCUpQ3W0GQR1XS
G-401 NVzGTW9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3RfmlKSzVyPUCuNFMxQTNizszN MnXtV2FPT0WU
OVCAR-8 NUHnbllyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMEOxNFch|ryP NXLhPJo6W0GQR1XS
IMR-5 M4TSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjiSGdKSzVyPUCuNFMzPDRizszN NHXtSGRUSU6JRWK=
DoTc2-4510 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjRblJKSzVyPUCuNFM{QTNizszN MUjTRW5ITVJ?
HOS Mlu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LNe2lEPTB;MD6wN|Q4OyEQvF2= MkD4V2FPT0WU
HEC-1 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S2XGlEPTB;MD6wN|Y5KM7:TR?= M1TkU3NCVkeHUh?=
SW756 M{fP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnZ[HVKSzVyPUCuNFM5OjFizszN M{jmfHNCVkeHUh?=
NCI-H64 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLy[ZpKSzVyPUCuNFM5PDJizszN MV7TRW5ITVJ?
EW-16 M2jN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEO5NFkh|ryP NHHONpNUSU6JRWK=
CAL-51 NFXDd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMESwNFUh|ryP NH3aN4RUSU6JRWK=
KYSE-150 NXj4SGh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMESwNVEh|ryP MoqxV2FPT0WU
SW1710 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMESwNVgh|ryP M1PicHNCVkeHUh?=
HuP-T4 NHO3fpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj5NItOUUN3ME2wMlA1OTF6IN88US=> NVi2dIMyW0GQR1XS
LB373-MEL-D M3vVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMESyN|Ih|ryP MYTTRW5ITVJ?
EW-13 NEHCempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMES0NFYh|ryP MUfTRW5ITVJ?
HT-29 NIXH[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMES0PUDPxE1? M2\nd3NCVkeHUh?=
SCC-25 NEfRNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\YTmlEPTB;MD6wOFQ6PCEQvF2= NI\xd4FUSU6JRWK=
REH NGO5eIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMES2N|Uh|ryP M4HxdnNCVkeHUh?=
L-363 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrUUXdSUUN3ME2wMlA1Pjd7IN88US=> NXPIRXNNW0GQR1XS
NCI-H1770 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMES2PVch|ryP MnS4V2FPT0WU
CHL-1 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMES4OVch|ryP M4nmN3NCVkeHUh?=
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SW954 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXZSWViUUN3ME2wMlQxOzN3IN88US=> M{XrTHNCVkeHUh?=
MES-SA M32wSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXMSXdKSzVyPUCuOFA2ODVizszN MU\TRW5ITVJ?
Ca-Ski MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTwTWM2OD1yLkSwOVI1KM7:TR?= MVvTRW5ITVJ?
SW13 NEKzW5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLYTWM2OD1yLkSwOlI3KM7:TR?= MXvTRW5ITVJ?
NCI-H1437 NYHSeJNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HKT2lEPTB;MD60NFgxPSEQvF2= NEHJUndUSU6JRWK=
U-118-MG Ml7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nKfmlEPTB;MD60NFkxPCEQvF2= MWXTRW5ITVJ?
NCI-H1734 Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3Lfm9KSzVyPUCuOFIxOTNizszN Mnr6V2FPT0WU
HDLM-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfteotVUUN3ME2wMlQzODN|IN88US=> Mmr1V2FPT0WU
AU565 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTBwNEK0Olgh|ryP MWnTRW5ITVJ?
FADU NF7LdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\DNFlkUUN3ME2wMlQzPjR7IN88US=> NIrzXoRUSU6JRWK=
OS-RC-2 NEL0OmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTmeWFrUUN3ME2wMlQ{ODh|IN88US=> NYjZTGxkW0GQR1XS
CAMA-1 M3;heGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwNEO2NlYh|ryP MX\TRW5ITVJ?
MONO-MAC-6 NYXhdGczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH2TWM2OD1yLkSzPFQ6KM7:TR?= M13pfnNCVkeHUh?=
LB831-BLC M4jxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf2RWxKSzVyPUCuOFQ{PzFizszN NV:yNZRMW0GQR1XS
SW982 NEK4OmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwNES1Nlgh|ryP MULTRW5ITVJ?
SCC-3 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS0UlJiUUN3ME2wMlQ1PTd7IN88US=> NHfqcplUSU6JRWK=
C32 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnm[mFNUUN3ME2wMlQ2OjJ7IN88US=> MnvrV2FPT0WU
BFTC-909 MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3R[Hh4UUN3ME2wMlQ2Ojl7IN88US=> MWjTRW5ITVJ?
MEG-01 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwNEWzO|Mh|ryP MlHwV2FPT0WU
M14 NWntdYRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK4TWM2OD1yLkS1PVc6KM7:TR?= MVPTRW5ITVJ?
MPP-89 NEWxPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr0TWM2OD1yLkS2NlU3KM7:TR?= M3HLcXNCVkeHUh?=
HCC1937 NWTxR3U3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zsPGlEPTB;MD60OlM5PCEQvF2= MmTRV2FPT0WU
SW837 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzlWHpOUUN3ME2wMlQ3PzJ{IN88US=> M{X1[XNCVkeHUh?=
DU-145 M4[1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXkdWZTUUN3ME2wMlQ3PzJ7IN88US=> M4WxNXNCVkeHUh?=
LB996-RCC NGLUeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTTUlRKSzVyPUCuOFcxPTRizszN MkjNV2FPT0WU
C8166 NH2xd5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3tVlRKSzVyPUCuOFc1KM7:TR?= MXPTRW5ITVJ?
MOLT-4 MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwNEe3N|Qh|ryP MX3TRW5ITVJ?
DMS-53 NEDRSGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNEe4NFkh|ryP MoX6V2FPT0WU
TE-5 NVv5e5VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m3W2lEPTB;MD60PFMxPSEQvF2= MknPV2FPT0WU
KYSE-520 M{TGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnRfIdSUUN3ME2wMlQ5OzR|IN88US=> NIDUNFdUSU6JRWK=
Detroit562 NWLFUphIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i0W2lEPTB;MD60PFg3KM7:TR?= NG\JOFZUSU6JRWK=
SIMA NHPqNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XuW2lEPTB;MD60PVQyPyEQvF2= NIq3WZlUSU6JRWK=
NCI-H1651 NVHLUmJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPKTWM2OD1yLkS5Olch|ryP MYrTRW5ITVJ?
HCC1599 MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nwXGlEPTB;MD60PVk2PSEQvF2= NEjMN5RUSU6JRWK=
ABC-1 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDTU45KSzVyPUCuOVA1QTZizszN NXPuZW97W0GQR1XS
CAL-33 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HkVGlEPTB;MD61NFg1PCEQvF2= MVzTRW5ITVJ?
OPM-2 MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzzTWM2OD1yLkWwPVM4KM7:TR?= M{HvbnNCVkeHUh?=
RPMI-7951 M1LSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;iVIN[UUN3ME2wMlUxQTV5IN88US=> NYfuRYIzW0GQR1XS
HT-1080 NWjiTpc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTGblhSUUN3ME2wMlUyOTF7IN88US=> M1Xo[HNCVkeHUh?=
LC4-1 NXvDc4d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e5c2lEPTB;MD61NVQxOyEQvF2= NYTPcFBxW0GQR1XS
OVCAR-3 NGfmfXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vVSWlEPTB;MD61NVU4KM7:TR?= MVLTRW5ITVJ?
CAPAN-1 NI\PXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlmwTWM2OD1yLkWyNlg5KM7:TR?= NXr0S4g{W0GQR1XS
SK-OV-3 M4XudWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwNUK0N|Qh|ryP MYjTRW5ITVJ?
HuP-T3 M1vUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInSdWRKSzVyPUCuOVI5OjdizszN NW\3[m82W0GQR1XS
NCI-H838 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwNUK4OFkh|ryP MYrTRW5ITVJ?
K5 NUXRcncxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDBUGNSUUN3ME2wMlU{OjBzIN88US=> M{DyNHNCVkeHUh?=
CAL-72 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCdGlEPTB;MD61N|M5PyEQvF2= Mmj0V2FPT0WU
NH-12 MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD3OGdnUUN3ME2wMlU{QTV7IN88US=> MkXDV2FPT0WU
SNB75 M3PNfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfHTWM2OD1yLkW1O|Mh|ryP MWDTRW5ITVJ?
BPH-1 NGnzOmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\QTWM2OD1yLkW2N|Q1KM7:TR?= M3TiWXNCVkeHUh?=
NOMO-1 M{DneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1y4N2lEPTB;MD61OlM4OiEQvF2= MoqxV2FPT0WU
G-402 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGyRVJKSzVyPUCuOVY1QTlizszN NV\1eWZrW0GQR1XS
NCI-H2052 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwNU[3OFEh|ryP NUG5NYR1W0GQR1XS
RCM-1 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HvdmlEPTB;MD61O|E3PiEQvF2= NGnueGpUSU6JRWK=
COR-L279 M1O0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX33PWROUUN3ME2wMlU4OTh3IN88US=> MXfTRW5ITVJ?
A253 M3rDeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknwTWM2OD1yLkW3OVI2KM7:TR?= NESxOphUSU6JRWK=
SK-MM-2 NX\ZVmFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fBfGlEPTB;MD61O|Y4QSEQvF2= M3nqU3NCVkeHUh?=
NCI-H1703 NEDE[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzWXppKSzVyPUCuOVk1OjdizszN M{ntcHNCVkeHUh?=
UACC-257 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz2TWM2OD1yLkW5OFg4KM7:TR?= MVjTRW5ITVJ?
KALS-1 MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfzTWM2OD1yLk[wNFEyKM7:TR?= MWLTRW5ITVJ?
ES5 NUjWOW1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;MNnNKSzVyPUCuOlA1QCEQvF2= NWnDToJoW0GQR1XS
MHH-CALL-2 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO3[mxyUUN3ME2wMlYxQDh6IN88US=> Mn3IV2FPT0WU
ChaGo-K-1 MkjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFr0[oVKSzVyPUCuOlEzOjlizszN M4\QPXNCVkeHUh?=
TGBC1TKB NH73TFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTWNWJmUUN3ME2wMlYyQThizszN M{XXVXNCVkeHUh?=
KU-19-19 NXG0TpZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXsTWM2OD1yLk[0OVg3KM7:TR?= NGPXW5FUSU6JRWK=
COLO-684 NULu[VhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnieIxKSzVyPUCuOlU3OTFizszN NVH2[WFnW0GQR1XS
LS-1034 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnkRotKSzVyPUCuOlU5OTlizszN NXPRfoZwW0GQR1XS
RT-112 NIDmdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfCT3k3UUN3ME2wMlY3PTh5IN88US=> NFLCbZNUSU6JRWK=
Capan-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNk[2NlIh|ryP NXfuOo5xW0GQR1XS
HSC-4 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknkTWM2OD1yLk[2Olk5KM7:TR?= NYrkVHl3W0GQR1XS
COLO-824 NWTiOodmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7oTWM2OD1yLk[3PFI{KM7:TR?= MXrTRW5ITVJ?
NCI-H2170 NILnVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT3R2NrUUN3ME2wMlY5OjV6IN88US=> MkPUV2FPT0WU
GDM-1 M3K3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LMd2lEPTB;MD62PFQ6PCEQvF2= MV3TRW5ITVJ?
KP-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLaTWM2OD1yLk[5OVc{KM7:TR?= M3HhdnNCVkeHUh?=
VA-ES-BJ M{XTO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTBwNkm5PFYh|ryP NVXQN4JqW0GQR1XS
KM-H2 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPGWlZKSzVyPUCuO|AxQTFizszN NVThNVFbW0GQR1XS
HH NILxbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwN{C2OlIh|ryP NIfGVopUSU6JRWK=
DK-MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwN{GwNVYh|ryP MljmV2FPT0WU
VM-CUB-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn5foZKSzVyPUCuO|EzPTlizszN MV3TRW5ITVJ?
COLO-829 MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXS5N4FyUUN3ME2wMlcyQTh3IN88US=> M2ftTnNCVkeHUh?=
OMC-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfpUVk{UUN3ME2wMlczOTB2IN88US=> M1T1b3NCVkeHUh?=
NB12 M{LlPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjCTWM2OD1yLkeyOVA1KM7:TR?= M3m3N3NCVkeHUh?=
NCI-H28 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXaTWM2OD1yLke0NFg{KM7:TR?= MkXQV2FPT0WU
A673 M{jVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELQ[Y9KSzVyPUCuO|UyPzdizszN MlnMV2FPT0WU
LB2241-RCC M1jXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mxZ2lEPTB;MD63OlA5PyEQvF2= M17zWXNCVkeHUh?=
CCRF-CEM MnnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwN{ewOVIh|ryP M2GyTHNCVkeHUh?=
NCI-H510A Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDiZpl3UUN3ME2wMlc4OTh4IN88US=> NX3MOmFpW0GQR1XS
SW48 NYTj[5loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTWdlJKSzVyPUCuO|c{OzNizszN MUDTRW5ITVJ?
NCI-H2081 NV\UVIJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS3Z|RKSzVyPUCuO|gyPDdizszN Mmf1V2FPT0WU
RMG-I M335NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwN{iyNVIh|ryP NEDRfmFUSU6JRWK=
LU-99A MmPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LrUGlEPTB;MD63PFQyOyEQvF2= MVTTRW5ITVJ?
KP-N-YS NFHsWWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwN{i5NlEh|ryP NUX4e5ZmW0GQR1XS
MDA-MB-231 MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrpSZpKSzVyPUCuPFAyOzFizszN NEXSV5hUSU6JRWK=
U031 NV[2XJQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLOd5NKSzVyPUCuPFE1OjNizszN M3fmTnNCVkeHUh?=
EVSA-T M2npdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTCeoxTUUN3ME2wMlgyPjd{IN88US=> MV\TRW5ITVJ?
MDA-MB-157 NVfuSHhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33pfWlEPTB;MD64NlI4OSEQvF2= M{fiN3NCVkeHUh?=
EHEB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGyTWM2OD1yLkiyNlc3KM7:TR?= M3XsbXNCVkeHUh?=
KINGS-1 NE\tVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIO2copKSzVyPUCuPFI2PTVizszN Mkm1V2FPT0WU
23132-87 NFu1SmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO1U3RKSzVyPUCuPFI5PDNizszN MlPoV2FPT0WU
EFO-21 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:zbWlEPTB;MD64OFA5QSEQvF2= M4f2d3NCVkeHUh?=
DOK MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXmZ3FWUUN3ME2wMlg1QCEQvF2= NGTVdW5USU6JRWK=
NCI-H2171 M2jVRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ezS2lEPTB;MD64OFk3KM7:TR?= MXLTRW5ITVJ?
NCI-SNU-5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nNPWlEPTB;MD64OVU4KM7:TR?= NIC0T|NUSU6JRWK=
SK-N-DZ MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwOEW5OFMh|ryP Ml3UV2FPT0WU
SNU-C2B MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwOE[4NFEh|ryP MnT1V2FPT0WU
CP66-MEL NH;Ed2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITESWNKSzVyPUCuPFcyOSEQvF2= NG\xfWpUSU6JRWK=
SN12C M1XlZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDjTWM2OD1yLki4OlM4KM7:TR?= NF3SfZpUSU6JRWK=
A172 NITRWmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3CTlZxUUN3ME2wMlg5Pjl6IN88US=> MkjNV2FPT0WU
NCI-H2347 NWDEPJI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\OV5Y1UUN3ME2wMlg5PzV|IN88US=> NEnT[FFUSU6JRWK=
NCI-H2228 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwOEmzN|kh|ryP NV3uNXBQW0GQR1XS
SNU-387 M1HvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PDW2lEPTB;MD65NFI3PCEQvF2= MlnpV2FPT0WU
SK-MEL-24 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HiPWlEPTB;MD65NVM1PCEQvF2= NV:w[mZpW0GQR1XS
MDA-MB-468 NUPEU5dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XaWmlEPTB;MD65NVc{KM7:TR?= MmPJV2FPT0WU
NCI-H1694 NWTrVY1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojRTWM2OD1yLkmxPFc3KM7:TR?= NH6zdoFUSU6JRWK=
CCF-STTG1 M{HafWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPNZYNKUUN3ME2wMlkzPjN5IN88US=> NWLKc3JjW0GQR1XS
K052 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXnSIFHUUN3ME2wMlk1ODR5IN88US=> NXX0cnROW0GQR1XS
NCI-H446 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TVSGlEPTB;MD65OVAyKM7:TR?= M1nrUnNCVkeHUh?=
MFE-280 M17nT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;SXYhEUUN3ME2wMlk3OjlzIN88US=> MY\TRW5ITVJ?
KU812 MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXNRnZKSzVyPUCuPVk{QDlizszN NXP1eZBiW0GQR1XS
MDA-MB-361 NVTUcG5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTjTWM2OD1yLkm5O|c4KM7:TR?= NX3TXZdYW0GQR1XS
Raji M4WzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTFwMEKyOlch|ryP MorTV2FPT0WU
TE-6 MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76TWM2OD1zLkCzOVY3KM7:TR?= M{D1O3NCVkeHUh?=
CAL-148 Mn64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPXUpZZUUN3ME2xMlA1PDR|IN88US=> MWTTRW5ITVJ?
NCI-H1963 MoflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[wS3R7UUN3ME2xMlA1PTV|IN88US=> NEXMbVZUSU6JRWK=
SK-N-AS M{PrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW0W5JYUUN3ME2xMlA1Pjh3IN88US=> NXTL[m1oW0GQR1XS
RERF-LC-MS MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwME[zOFkh|ryP NVHSWVVjW0GQR1XS
BEN M{jaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwMEexN|ch|ryP NHXXd3BUSU6JRWK=
CAS-1 M2rRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLyTWM2OD1zLkC5NVI{KM7:TR?= NXHmXGVEW0GQR1XS
SW780 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoftTWM2OD1zLkC5NVgyKM7:TR?= M4rwTnNCVkeHUh?=
LU-65 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v1PGlEPTB;MT6wPVQyKM7:TR?= NXv2RlNXW0GQR1XS
D-283MED NXj5S5RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjOOYhKSzVyPUGuNVIzPzJizszN NWHnXGE2W0GQR1XS
HCC2157 NX;SW|NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XZcWlEPTB;MT6xN|Y1OiEQvF2= MUXTRW5ITVJ?
RCC10RGB MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwMUSwNFYh|ryP Mle2V2FPT0WU
PLC-PRF-5 NHXO[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwMUWyNlkh|ryP MYnTRW5ITVJ?
H4 NGPjTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTFwMUW0N|kh|ryP NV64RZhPW0GQR1XS
TUR MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfjNGpEUUN3ME2xMlE2PzV{IN88US=> Mn;XV2FPT0WU
NCI-H2141 NFi5UYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTFwMUi5OFYh|ryP NIrC[4xUSU6JRWK=
PFSK-1 NXzQOmY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFwMkC1N|Ih|ryP Mkm3V2FPT0WU
SK-MEL-28 M3Lt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TnS2lEPTB;MT6yN|IzOSEQvF2= MnjNV2FPT0WU
SCC-9 M4rvWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLOW|N5UUN3ME2xMlI{PjZ3IN88US=> M1rDc3NCVkeHUh?=
T47D MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zmXGlEPTB;MT6yN|Y6PiEQvF2= MlXFV2FPT0WU
TCCSUP MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n0WWlEPTB;MT6yOVAzQSEQvF2= M4fOe3NCVkeHUh?=
SU-DHL-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXDR3ppUUN3ME2xMlI2OTF6IN88US=> NXHjR4hzW0GQR1XS
HL-60 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LXb2lEPTB;MT6yOVU5QCEQvF2= MU\TRW5ITVJ?
NCI-H1436 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoezTWM2OD1zLkK2NVQ6KM7:TR?= MkPVV2FPT0WU
DMS-114 NYTsWZZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVuySVhpUUN3ME2xMlI3PjN{IN88US=> M{[3SHNCVkeHUh?=
BOKU NFzoUmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWxcJl3UUN3ME2xMlI5ODl3IN88US=> NVLNbYRTW0GQR1XS
MS-1 M2PYcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTFwMkmwOlkh|ryP MmfFV2FPT0WU
NCI-H661 Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHkPVRKSzVyPUGuN|A1PzhizszN MYPTRW5ITVJ?
HT-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLLOJNqUUN3ME2xMlMxPTJ7IN88US=> NVfme3llW0GQR1XS
CAL-54 M{e5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfBT2xKSzVyPUGuN|A4OjVizszN NVnlNWdFW0GQR1XS
SW1463 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwM{G4O|Ih|ryP NF7rXGFUSU6JRWK=
COLO-668 NVuyeVdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInjfnhKSzVyPUGuN|MxPTZizszN MWDTRW5ITVJ?
PANC-08-13 NYL5SIl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjJe3lvUUN3ME2xMlM{QDB|IN88US=> MYrTRW5ITVJ?
BB49-HNC NHPmVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTFwM{SwNUDPxE1? MXHTRW5ITVJ?
M059J M{jkNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFwM{W4N|Ih|ryP M1nQ[3NCVkeHUh?=
NCCIT MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HEfWlEPTB;MT6zO|k5QCEQvF2= Mo[zV2FPT0WU
LN-405 MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHx[oxKSzVyPUGuN|kzPjRizszN MkG4V2FPT0WU
UMC-11 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHRTWM2OD1zLkO5PVk3KM7:TR?= NVzZbFM{W0GQR1XS
NB5 NUO0cVF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfOcZZuUUN3ME2xMlQyOjJ5IN88US=> M33UXXNCVkeHUh?=
TE-441-T MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPNfFNHUUN3ME2xMlQzQDF5IN88US=> M13Sc3NCVkeHUh?=
ME-180 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTCbZpMUUN3ME2xMlQ1Ozl{IN88US=> MnTiV2FPT0WU
HCC70 NGfTbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nmbGlEPTB;MT60OlA6PiEQvF2= MmDyV2FPT0WU
no-10 NH;N[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwNE[xPFEh|ryP MlW2V2FPT0WU
JEG-3 NUHxXppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwNUCxN|Ih|ryP MYfTRW5ITVJ?
no-11 MlWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFwNUC4PFIh|ryP MnvvV2FPT0WU
CHP-126 M1ewVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFwNU[2PVEh|ryP MoT4V2FPT0WU
EGI-1 M{fmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwNUiwNlUh|ryP M1TYfnNCVkeHUh?=
D-392MG NWKwSI95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnsOWpKSzVyPUGuOVk3OyEQvF2= M3:y[HNCVkeHUh?=
RT4 NWj5dlRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPKTWM2OD1zLkW5OlM4KM7:TR?= MWLTRW5ITVJ?
A204 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj2TWM2OD1zLkW5PFAyKM7:TR?= NIrON2hUSU6JRWK=
NCI-H1304 NWPZPVN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S3[2lEPTB;MT62N|U6OSEQvF2= NHznV5FUSU6JRWK=
Becker MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjUTZZKSzVyPUGuOlQzPDFizszN MmS2V2FPT0WU
OE19 M{fs[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwNkW1NVgh|ryP NXq3ZnA4W0GQR1XS
EKVX NF\GTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjoNYhKSzVyPUGuOlU3OThizszN NYHNcIx3W0GQR1XS
KLE MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDtdJlKSzVyPUGuOlU4OTRizszN NFXpcnRUSU6JRWK=
K-562 NIDZOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3XXXUxUUN3ME2xMlY4ODN5IN88US=> MV\TRW5ITVJ?
MDA-MB-175-VII MkfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTFwNki5PVch|ryP NEHvbndUSU6JRWK=
NCI-H716 M1HyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwNkmzNFQh|ryP MWHTRW5ITVJ?
Caov-3 NHzwR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFwNkm0NVMh|ryP NUfqeW1mW0GQR1XS
HCC1187 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnGyTWM2OD1zLkewOVQ2KM7:TR?= NWjsellUW0GQR1XS
CAKI-1 NHjI[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfa[pdHUUN3ME2xMlczOjl{IN88US=> M3nsRnNCVkeHUh?=
MOLT-16 NYr5XIhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTFwN{OzNFch|ryP NIrOVI9USU6JRWK=
PC-3 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq3TWM2OD1zLke1NFgh|ryP NVvpUYhtW0GQR1XS
DV-90 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PjR2lEPTB;MT63OVU5PSEQvF2= Ml3sV2FPT0WU
RXF393 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHnTWM2OD1zLke3Nlk1KM7:TR?= MkXQV2FPT0WU
SK-NEP-1 M2HKOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL4T3dKSzVyPUGuPFI{OzlizszN M3X1fHNCVkeHUh?=
HCC1419 M2nDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC0TWM2OD1zLkiyOlkzKM7:TR?= MXrTRW5ITVJ?
BV-173 NYj6WldVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGexToNKSzVyPUGuPFI6QTVizszN MVrTRW5ITVJ?
MKN7 M{\tcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXThV3VbUUN3ME2xMlg6OjJizszN NHi1NHZUSU6JRWK=
LAN-6 NFXNWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwOEm1OVMh|ryP M{TSV3NCVkeHUh?=
Mo-T MmHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fBTWlEPTB;MT65NFA{QSEQvF2= NGTGS3VUSU6JRWK=
HCC1395 NFTPS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj3TWM2OD1zLkmyPFY{KM7:TR?= M2XRPHNCVkeHUh?=
HC-1 NXPVfZpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3WWZJIUUN3ME2xMlk{PDdizszN NX\RSnpnW0GQR1XS
HPAF-II M3jDbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLCTWM2OD1zLkm0OFE5KM7:TR?= M2nhT3NCVkeHUh?=
CPC-N M1Hzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LiZWlEPTB;MT65PFAxOiEQvF2= NHLjTnlUSU6JRWK=
MKN45 M{ThO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj0TWM2OD1zLkm5NVE6KM7:TR?= MVfTRW5ITVJ?
NCI-H1693 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;qdnJQUUN3ME2yMlAxPDN|IN88US=> MlzTV2FPT0WU
SHP-77 M{\3Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfjVmhXUUN3ME2yMlAxPTN|IN88US=> NYTGWYVxW0GQR1XS
NCI-H1522 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm5TWM2OD1{LkCxO|I1KM7:TR?= MkHzV2FPT0WU
SW1573 MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJwMEKyJO69VQ>? NXLV[nFxW0GQR1XS
DBTRG-05MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LPN2lEPTB;Mj6wOlA5PyEQvF2= NVjoSYNMW0GQR1XS
SCC-4 M3:3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jYTmlEPTB;Mj6xOFMyKM7:TR?= NIS5cWdUSU6JRWK=
DMS-153 NIfKUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzXbFlKSzVyPUKuNVY3PjhizszN NWP6N5p1W0GQR1XS
MDA-MB-415 NH2yOVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwMUe1NkDPxE1? M2X2VXNCVkeHUh?=
NCI-H2126 MofnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3UZWExUUN3ME2yMlIzQDh6IN88US=> NXH1WZdIW0GQR1XS
MDA-MB-453 NE\5W2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnlTWM2OD1{LkKzN|Ih|ryP MV7TRW5ITVJ?
U-87-MG M3TR[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED2U3lKSzVyPUKuNlg2QTJizszN M3zNUnNCVkeHUh?=
LNCaP-Clone-FGC NE\2SG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwM{CxNFIh|ryP MWnTRW5ITVJ?
NCI-H1581 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fafmlEPTB;Mj6zNlExPSEQvF2= NGHUPYJUSU6JRWK=
BC-3 M{n0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;uZZZKSzVyPUKuN|Y2ODlizszN M2DTc3NCVkeHUh?=
HCC38 M3jHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j4XmlEPTB;Mj6zPFQ1PyEQvF2= MWjTRW5ITVJ?
HCC2218 NFPJbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vLUmlEPTB;Mj60NFgxQSEQvF2= M1P1O3NCVkeHUh?=
RO82-W-1 M1;ST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwNEGyOUDPxE1? NWD6e2o4W0GQR1XS
C2BBe1 NVnlRot5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH6e2RKSzVyPUKuOFE2PzhizszN M{nEO3NCVkeHUh?=
LAMA-84 NWrTPVJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP6TWM2OD1{LkW3N|Y5KM7:TR?= Ml;qV2FPT0WU
GMS-10 NGOze4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzieVhKSzVyPUKuOVc3OTFizszN MX3TRW5ITVJ?
GCT NH7XRWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnM[2lKSzVyPUKuOVg3QTRizszN MXLTRW5ITVJ?
SK-CO-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwNkG2OkDPxE1? NVrIdnprW0GQR1XS
NCI-H526 NVrFNW5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zQcGlEPTB;Mj62N|Q2KM7:TR?= NF;i[FhUSU6JRWK=
SW1088 NWe1UItGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;hWmlEPTB;Mj63O|g{QSEQvF2= M3q3R3NCVkeHUh?=
HT55 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnkSJlKSzVyPUKuO|g3QTVizszN MmP5V2FPT0WU
NB10 M2fKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2faTmlEPTB;Mj64NVc1QCEQvF2= MV\TRW5ITVJ?
UACC-893 NYXCN5ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\rTWM2OD1{Lki1O|Q6KM7:TR?= MknsV2FPT0WU
NCI-H1618 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4S1WmlEPTB;Mj64PFE2OyEQvF2= M3XSTnNCVkeHUh?=
NCI-H1092 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjoPI9KSzVyPUOuNFc5OTJizszN NF:xWpFUSU6JRWK=
SBC-1 NIL0eIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzHTWM2OD1|LkC4OVU{KM7:TR?= NIrucI9USU6JRWK=
NCI-H1623 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PZ[WlEPTB;Mz6wPVM1KM7:TR?= MXrTRW5ITVJ?
SiHa NH3rOGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO4cWhkUUN3ME2zMlEyQTd5IN88US=> M3XBUHNCVkeHUh?=
D-263MG MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjOT4ljUUN3ME2zMlE1Pzh6IN88US=> NFHo[ohUSU6JRWK=
NCI-H1573 NF\IXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH3cJV3UUN3ME2zMlE6PjRzIN88US=> MlX0V2FPT0WU
NCI-H82 NGjZZ5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTNwM{S0N|kh|ryP MlXiV2FPT0WU
NCI-H2196 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe2VFdEUUN3ME2zMlM2ODB6IN88US=> MkPnV2FPT0WU
MFM-223 M3nJbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzITWM2OD1|LkO3N|UyKM7:TR?= MmjMV2FPT0WU
COLO-678 M2rBd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXGNXFKSzVyPUOuN|gyQDZizszN M{DUd3NCVkeHUh?=
EW-3 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrpWGl7UUN3ME2zMlQxQTVizszN M33KZ3NCVkeHUh?=
MHH-NB-11 NIf3U5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPmd|VbUUN3ME2zMlQ1ODZ7IN88US=> NGXFV2JUSU6JRWK=
EM-2 M1jxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P1XGlEPTB;Mz62N|k5KM7:TR?= MUnTRW5ITVJ?
FTC-133 NYrQSGhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\5c5dKSzVyPUOuOlU1PThizszN NUHBPYE4W0GQR1XS
NCI-H209 MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUn3SJM2UUN3ME2zMlY4PjV|IN88US=> M4X6WHNCVkeHUh?=
TGBC24TKB NUm1dpR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDQTWM2OD1|Lk[4N|U2KM7:TR?= MlTwV2FPT0WU
LC-1F NGnBWYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;SUFFKSzVyPUOuO|E4PjRizszN NVvwUJRoW0GQR1XS
C-4-II NEPldllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTNwN{W2OFMh|ryP M2rCW3NCVkeHUh?=
NCI-H1650 NEnGOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4O1XGlEPTB;Mz63PFQ2PSEQvF2= NUj4TGJxW0GQR1XS
JVM-2 M1nSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDUb3BKSzVyPUOuPVM3OzlizszN M2X4UXNCVkeHUh?=
CaR-1 MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNwOUe2NVch|ryP MV3TRW5ITVJ?
MDA-MB-134-VI MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPlTWM2OD12LkCyPVUzKM7:TR?= M4HJXXNCVkeHUh?=
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IST-SL1 MlzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTZwNUO5OFgh|ryP NVy3V3h2W0GQR1XS
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NCI-H1155 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T1ZWlEPTB;Nj65OVU5OSEQvF2= Moe1V2FPT0WU
EFE-184 MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLETWM2OD15LkOxOlk2KM7:TR?= MnzWV2FPT0WU
AsPC-1 MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LJdmlEPTB;Nz60PFgxPyEQvF2= M{TkU3NCVkeHUh?=
SW948 NXjROHd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrQTWM2OD15LkW4N|k2KM7:TR?= MWHTRW5ITVJ?
NCI-H524 NHvH[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTlwNUi2Nlgh|ryP MWnTRW5ITVJ?
KOSC-2 M4TqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfycYlKSzVyPUmuOlI5OzRizszN NH[yPYxUSU6JRWK=
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NCI-H748 NE\6[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVGyXIw{UUN3ME2xNE43Ozl5IN88US=> Mo[4V2FPT0WU
NCI-H23 M3K2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XJ[2lEPTB;MUCuOlQ1OiEQvF2= NWPFeGZ7W0GQR1XS
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LB647-SCLC Ml6zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LSR2lEPTB;MUWuO|E6PSEQvF2= MXPTRW5ITVJ?
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NCI-H1563 NUHNSG1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXiNm5KSzVyPUG4Mlc3ODFizszN Ml2yV2FPT0WU
RL Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLoTWM2OD1{MT6yOlU3KM7:TR?= NGTL[mVUSU6JRWK=
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NCI-H1793 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjVXGM3UUN3ME2yPE42PDl7IN88US=> NGTBTFJUSU6JRWK=
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LS-513 NF\IPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTN3Lki4O|kh|ryP MmSyV2FPT0WU
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KARPAS-299 M3jJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH1TWM2OD12Nz6xPVk{KM7:TR?= MnjqV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2
NCT00724841 Terminated Metastatic Melanoma Gemin X|Teva Pharmaceutical Industries June 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID