Obatoclax Mesylate (GX15-070)

Name: Obatoclax Mesylate (GX15-070)
Brand: Selleck Chemicals
SKU: S1057
Rating: 5 (105 reviews)

For research use only.

Catalog No.S1057

105 publications

Obatoclax Mesylate (GX15-070) Chemical Structure

CAS No. 803712-79-0

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with K_i of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Selleck's Obatoclax Mesylate (GX15-070) has been cited by 105 publications

Cancer Cell, 2019, 36(1):68-83

PubMed: 31257073 ( click the link to review the publication )

Nature, 2017, 551(7679):247-250

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Cell, 2010, 20;142(4):590-600.

PubMed: 20723759 ( click the link to review the publication )

Transl Oncol, 2021, 14(8):101116

PubMed: 33975180 ( click the link to review the publication )

Biomaterials, 2020, 232:119709

PubMed: 31896513 ( click the link to review the publication )

Int J Mol Sci, 2020, 5;21(5) pii: E1773

PubMed: 32150830 ( click the link to review the publication )

Invest New Drugs, 2020, 4

PubMed: 32367199 ( click the link to review the publication )

NPJ Breast Cancer, 2020, 6:30

PubMed: 32715085 ( click the link to review the publication )

Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.04.011

PubMed: 31155509 ( click the link to review the publication )

Int J Mol Sci, 2019, 20(6)

PubMed: 30875757 ( click the link to review the publication )

Front Microbiol, 2019, 10:2236

PubMed: 31636613 ( click the link to review the publication )

Prostate, 2019, 79(11):1347-1359

PubMed: 31228231 ( click the link to review the publication )

Cancers (Basel), 2018, 10(12)

PubMed: 30563080 ( click the link to review the publication )

Cell Death Discov, 2018, 4:107

PubMed: 30479840 ( click the link to review the publication )

Cell Death Dis, 2018, 92(10)

PubMed: 23640461 ( click the link to review the publication )

Antioxidants (Basel), 2018, 10.3390/antiox7110150

PubMed: 30373097 ( click the link to review the publication )

BMC Cancer, 2018, 18(1):965

PubMed: 30305055 ( click the link to review the publication )

J Clin Invest, 2017, 127(1):153-168

PubMed: 27893461 ( click the link to review the publication )

Cancer Res, 2017, 77(13):3513-3526

PubMed: 28522750 ( click the link to review the publication )

Cancer Res, 2017, 10.1158/0008-5472.CAN-16-3424

PubMed: ( click the link to review the publication )

Genome Med, 2017, 9(1):40

PubMed: 28446242 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):52

PubMed: 28403890 ( click the link to review the publication )

Arch Toxicol, 2017, 91(5):2191-2208

PubMed: 27807597 ( click the link to review the publication )

FEBS J, 2017, 284(2):222-236

PubMed: 27860276 ( click the link to review the publication )
Antimicrob Agents Chemother, 2017, 61(3)

PubMed: 27993855 ( click the link to review the publication )

Electrophoresis, 2017, 10.1002/elps.201600447

PubMed: 28608427 ( click the link to review the publication )

J Exp Med, 2017, 214(6):1691-1710

PubMed: 28450382 ( click the link to review the publication )

Oncotarget, 2017, 8(5):8670-8678

PubMed: 28055968 ( click the link to review the publication )

Viruses, 2017, 9(10)

PubMed: 28946654 ( click the link to review the publication )

Blood, 2016, 6;128(14):1834-1844

PubMed: 27465916 ( click the link to review the publication )

Nat Commun, 2016, 7:11190

PubMed: 27048913 ( click the link to review the publication )

Autophagy, 2016, 2;12(6):999-1014

PubMed: 27124102 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(21):5370-5382

PubMed: 27178741 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2016, 113(46):13150-13155

PubMed: 27799526 ( click the link to review the publication )

ACS Appl Mater Interfaces, 2016, 8(21):13218-31

PubMed: 27160664 ( click the link to review the publication )

Antiviral Res, 2016, 126:69-80

PubMed: 26738783 ( click the link to review the publication )

Cancer Cell Int, 2016, 16:27

PubMed: 27042160 ( click the link to review the publication )

Int J Oncol, 2016, 49(3):953-60

PubMed: 27572939 ( click the link to review the publication )

Oncotarget, 2016, 7(3):3520-32

PubMed: 26657288 ( click the link to review the publication )

Tumour Biol, 2016, 37(8):10839-49

PubMed: 26880588 ( click the link to review the publication )

Oncotarget, 2016, 7(50):82013-82027

PubMed: 27852038 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2357-2369

PubMed: 27512118 ( click the link to review the publication )

Oncotarget, 2016, 7(35):56253-56265

PubMed: 27494845 ( click the link to review the publication )

Oncotarget, 2016,

PubMed: 26910910 ( click the link to review the publication )

Oncotarget, 2016, 8(36):60060-60079

PubMed: 28947954 ( click the link to review the publication )

Oncotarget, 2016, 7(23):34453-71

PubMed: 27144341 ( click the link to review the publication )

Nat Chem Biol, 2015, 10.1038/nchembio.1986

PubMed: 26656090 ( click the link to review the publication )

Genes Dev, 2015, 29(20):2140-52

PubMed: 26494789 ( click the link to review the publication )
Int J Cancer, 2015, 137(12):2959-70

PubMed: 26096065 ( click the link to review the publication )

Cancer Lett, 2015, 10.1016/j.canlet.2015.05.008

PubMed: 25979228 ( click the link to review the publication )

Cell Death Dis, 2015, 6:e2014

PubMed: 26658189 ( click the link to review the publication )

Mol Oncol, 2015, 9(2):409-21

PubMed: 25308513 ( click the link to review the publication )

Mol Oncol, 2015, 9(2):409-21

PubMed: ( click the link to review the publication )

J Biol Chem, 2015, 290(34):20841-55

PubMed: 26124276 ( click the link to review the publication )

Cancer Cell Int, 2015, 15:97

PubMed: 26464561 ( click the link to review the publication )

Int J Oncol, 2015, 46(4):1844-8

PubMed: 25647738 ( click the link to review the publication )

Phys Chem Chem Phys, 2015, 17(39):25946-55

PubMed: 26120608 ( click the link to review the publication )

BMC Cancer, 2015, 15:919

PubMed: 26585594 ( click the link to review the publication )

BMC Cancer, 2015, 15:568

PubMed: 26231047 ( click the link to review the publication )

Open Biol, 2015, 5(3)

PubMed: 25761368 ( click the link to review the publication )

Mol Cells, 2015, 38(3):279-84

PubMed: 25666350 ( click the link to review the publication )

Oral Dis, 2015,

PubMed: 25482163 ( click the link to review the publication )

Cell Biochem Funct, 2015, 33(5):334-40

PubMed: 26178811 ( click the link to review the publication )

Anticancer Drugs, 2015, 26(3):331-42

PubMed: 25521557 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26008975 ( click the link to review the publication )

Arch Pharm Chem Life Sci, 2015, 348: 1-11

PubMed: 25641608 ( click the link to review the publication )

J Pharm Pharmacol, 2015, 67(11):1575-84

PubMed: 26255619 ( click the link to review the publication )

Oncotarget, 2015, 6(40):42445-67

PubMed: 26636651 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 25749045 ( click the link to review the publication )

Cancer Lett, 2014, 348(1-2):20-8

PubMed: 24534203 ( click the link to review the publication )

Endocr Relat Cancer, 2014, 21(5):755-67

PubMed: 25012986 ( click the link to review the publication )

Oral Oncol, 2014, 50(2):120-7

PubMed: 24216166 ( click the link to review the publication )
Antimicrob Agents Chemother, 2014, 58(7):3689-96

PubMed: 24752266 ( click the link to review the publication )

Biochem Pharmacol, 2014, 92(1):55-61

PubMed: 25107702 ( click the link to review the publication )

J Biol Chem, 2014, 289(38):26481-91

PubMed: 25096574 ( click the link to review the publication )

Exp Cell Res, 2014, 322(1):217-25

PubMed: 24355809 ( click the link to review the publication )

Life Sci, 2014, 10.1016/j.lfs.2014.07.006

PubMed: 25066930 ( click the link to review the publication )

Oncol Rep, 2014, 32(6):2789-94

PubMed: 25333301 ( click the link to review the publication )

J Cell Biochem, 2014, 115(9):1624-35

PubMed: 24788582 ( click the link to review the publication )

PLoS One, 2014, 9(11):e111927

PubMed: 25409302 ( click the link to review the publication )

PLoS One, 2014, 9(10):e111146

PubMed: 25343454 ( click the link to review the publication )

PLoS One, 2014, 9(9):e106571

PubMed: 25192188 ( click the link to review the publication )

Genes Cancer, 2014, 5(11-12):445-59

PubMed: 25568669 ( click the link to review the publication )

Erasmus University Rotterdam, 2014, 978-94-6259-077-9

PubMed: http://repub.eur.nl/pub/50827/ ( click the link to review the publication )

Assay Drug Dev Technol, 2014, 12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2013, 110(11):4321-6

PubMed: 23447565 ( click the link to review the publication )

Int J Cancer, 2013, 133(8):1813-24

PubMed: 23580240 ( click the link to review the publication )

Cell Death Dis, 2013,

PubMed: 23681223 ( click the link to review the publication )

Cell Death Dis, 2013, 4:e742

PubMed: 23887633 ( click the link to review the publication )

Mol Cancer Ther, 2013, 12(4):448-59

PubMed: 23395885 ( click the link to review the publication )

J Immunol, 2013, 190(9):4621-6

PubMed: 23547112 ( click the link to review the publication )

Apoptosis, 2013, 18(10):1163-74

PubMed: 23887890 ( click the link to review the publication )

Am J Respir Cell Mol Biol, 2013, 49(4):609-18

PubMed: 23668615 ( click the link to review the publication )

Cancer Biol Ther, 2013, 14(10):982-96

PubMed: 24025251 ( click the link to review the publication )

Exp Cell Res, 2013, 319(10):1443-50

PubMed: 23416067 ( click the link to review the publication )

PLoS One, 2013, 8(2):e55982

PubMed: 23418490 ( click the link to review the publication )
Helsinki Metropolia University, 2013, Jens Desloovere

PubMed: ( click the link to review the publication )

Cancer Res, 2012, 72(12):3069-79

PubMed: 22525702 ( click the link to review the publication )

Oncogene, 2012, 32(37):4331-42

PubMed: 23085751 ( click the link to review the publication )

Cancer Lett, 2012, 339(2):288-97

PubMed: 23200668 ( click the link to review the publication )

Cell Death Dis, 2012, 3:e351

PubMed: 22825469 ( click the link to review the publication )

Cell Death Dis, 2012, 3:e299

PubMed: 22513873 ( click the link to review the publication )

Toxicol Sci, 2012, 128(1):79-91

PubMed: 22491427 ( click the link to review the publication )

Cancer Res, 2011, 71(13):4494-505

PubMed: 21555370 ( click the link to review the publication )

BMC Cancer, 2011, 11:24

PubMed: 21247487 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with K_i of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Features

Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.

Targets

Bcl-2 ^[1]
(Cell-free assay)

0.22 μM(Ki)

In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. ^[1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. ^[2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. ^[3]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
KARPAS-45	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIPtTWxKSzVyPUCuNFAxODNzNzFOwG0>	NEjpdo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SK-MEL-30	NFPnVGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlPNTWM2OD1yLkCwNFM2PSEQvF2=	NV71VotMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
NALM-6	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{T1SmlEPTB;MD6wNFA{PTZizszN	Mmq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
KYSE-450	MorxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXiTWM2OD1yLkCwNFQ3QSEQvF2=	NEC0Z5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
BHY	M1\MfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXPTWM2OD1yLkCwNFYxOSEQvF2=	NID1TZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
GR-ST	NVTwZ203T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2qycmlEPTB;MD6wNFA3PDhizszN	MoGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
786-0	NEXQ[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUH2bpNYUUN3ME2wMlAxODd5NjFOwG0>	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
C-33-A	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlzGTWM2OD1yLkCwNFg1QCEQvF2=	M4nCRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
BHT-101	NVS5Z2l1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{jZUmlEPTB;MD6wNFExPiEQvF2=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
EB2	M3\ld2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGLDeYhKSzVyPUCuNFAyOThizszN	NULn[XYzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
G-361	MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEm1N\|BKSzVyPUCuNFAyOjRizszN	NWDDeXJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KE-37	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mmi1TWM2OD1yLkCwNVI5KM7:TR?=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
MHH-PREB-1	Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkOxTWM2OD1yLkCwNVQh\|ryP	MoCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
MCF7	NVrGdHVJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTBwMECxOVkh\|ryP	NFv2cJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
LOUCY	MnjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{jBfGlEPTB;MD6wNFE4PSEQvF2=	NF7LN5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
EW-7	M3fESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTBwMECxO\|Uh\|ryP	NYjTRlhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KYSE-510	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NITJcINKSzVyPUCuNFAzOzNizszN	NYXyT3FURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SK-MEL-3	M2rKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV3JR\|UxRTBwMECyOlQh\|ryP	MnTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
HAL-01	NF\BWZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTBwMECyPVch\|ryP	MlS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
HCC2998	NH7kW3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLNTWM2OD1yLkCwN\|M2KM7:TR?=	NYjRe4hkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
A375	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYjadW85UUN3ME2wMlAxOzVizszN	NFLJdVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MZ7-mel	NYTYd21TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXvRo1KSzVyPUCuNFA{QTlizszN	M1zmWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
SH-4	NGHBSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkWxTWM2OD1yLkCwOFE4KM7:TR?=	NID4ZWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
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CAL-62	NUjLO5F3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLiblFjUUN3ME2wMlAzPjB{IN88US=>	M2PCbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
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UM-UC-3	MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHPNdJpKSzVyPUCuNlkyPCEQvF2=	MlKyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
CAL-120	M3u1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmD2TWM2OD1yLkK5OlMyKM7:TR?=	NIL6ToY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
UACC-62	Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVvvb\|BoUUN3ME2wMlMxOjRzIN88US=>	NILWZ2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
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KS-1	NF\RRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUO0WlZkUUN3ME2wMlMxPTJ4IN88US=>	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
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Calu-1	NU[weHdnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTaTWM2OD1yLkOxNlg6KM7:TR?=	NH3ScVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
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RPMI-8226	MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTBwM{G2OFEh\|ryP	M3G5XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
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NMC-G1	Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYniZodHUUN3ME2wMlMyQDZizszN	NEjFZ5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SJRH30	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3fuU2lEPTB;MD6zNlA2OiEQvF2=	MmnRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
COR-L105	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1rORWlEPTB;MD6zNlIyQCEQvF2=	NFr3RXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
IM-9	MlLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWjyN2tkUUN3ME2wMlM{ODJzIN88US=>	MkPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
TE-12	NHjoc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmrzTWM2OD1yLkOzN\|E4KM7:TR?=	M3G2cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
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U251	MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{WxfWlEPTB;MD6zN\|Q2PiEQvF2=	NHv1dpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
EFO-27	M2PEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrlOoRKSzVyPUCuN\|M6PTFizszN	NHLnSIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
EW-24	MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3mxVWlEPTB;MD6zN\|k5PCEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
SF295	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUj6WokyUUN3ME2wMlM{QTl7IN88US=>	NEnEUmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MC-IXC	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mom3TWM2OD1yLkO0OUDPxE1?	M2jpflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H2405	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTBwM{S3N\|Ih\|ryP	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NCI-H2009	M3:wNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIT0WnBKSzVyPUCuN\|Q4OzlizszN	NHnJS3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
LB1047-RCC	M1fjNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTBwM{W4NVUh\|ryP	NWTMS\|ZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KNS-81-FD	MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGDpeWFKSzVyPUCuN\|Y3PjdizszN	NXTWW4lCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HOP-92	NUn1XHZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Moi5TWM2OD1yLkO2PFMh\|ryP	NH7DZpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
L-428	NGHWXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvvUXpKSzVyPUCuN\|cxOTZizszN	M1XUV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
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NCI-H1792	M4fV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlH5TWM2OD1yLkO3OlU2KM7:TR?=	NFXscW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
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HT-1197	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFjw[pFKSzVyPUCuN\|k1PiEQvF2=	NWfCc5RURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
CGTH-W-1	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEn0XZRKSzVyPUCuN\|k6OTNizszN	MoTZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
KNS-42	M1\pWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mly0TWM2OD1yLkSwNFQ2KM7:TR?=	MnL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
HuO-3N1	MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkP2TWM2OD1yLkSwNFU2KM7:TR?=	MmDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
VMRC-RCZ	NYPaWYJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHHMOo1KSzVyPUCuOFA{ODNizszN	NVrETY0zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SW954	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkfDTWM2OD1yLkSwN\|M2KM7:TR?=	MoXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
MES-SA	M{nJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4rsUGlEPTB;MD60NFUxPSEQvF2=	NHjidnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
Ca-Ski	NFHCdJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnftTWM2OD1yLkSwOVI1KM7:TR?=	NEL6[VU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SW13	NXTrbXh4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfqTWM2OD1yLkSwOlI3KM7:TR?=	Mm[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H1437	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3m2d2lEPTB;MD60NFgxPSEQvF2=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
U-118-MG	NID6bnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFrTcZZKSzVyPUCuOFA6ODRizszN	MkW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H1734	MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnBTWM2OD1yLkSyNFE{KM7:TR?=	NEHTNG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
HDLM-2	MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlzYTWM2OD1yLkSyNFM{KM7:TR?=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
AU565	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnfnTWM2OD1yLkSyOFY5KM7:TR?=	NIXMVGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
FADU	Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmfXTWM2OD1yLkSyOlQ6KM7:TR?=	MlG5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
OS-RC-2	NEfpW4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYnJR\|UxRTBwNEOwPFMh\|ryP	MnHYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
CAMA-1	NEfvbGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVPJR\|UxRTBwNEO2NlYh\|ryP	NHfpXZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MONO-MAC-6	M4LxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXMdppKSzVyPUCuOFM5PDlizszN	NF;iNlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
LB831-BLC	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTBwNESzO\|Eh\|ryP	NXnVb5VmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SW982	M3TWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MY\JR\|UxRTBwNES1Nlgh\|ryP	M1yzNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
SCC-3	M1XYXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHr6b3JKSzVyPUCuOFQ2PzlizszN	MlX6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
C32	NWjEV3ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NULjPIRKUUN3ME2wMlQ2OjJ7IN88US=>	NWPCcFhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
BFTC-909	MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MonnTWM2OD1yLkS1Nlk6KM7:TR?=	NH;ZR3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MEG-01	M2HPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmrqTWM2OD1yLkS1N\|c{KM7:TR?=	MlXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
M14	NHrWcmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYDJR\|UxRTBwNEW5O\|kh\|ryP	NFK4e5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
MPP-89	MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2fEdGlEPTB;MD60OlI2PiEQvF2=	NYXEVo1URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HCC1937	NVjvd3N7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoDUTWM2OD1yLkS2N\|g1KM7:TR?=	MkHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
SW837	Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTBwNE[3NlIh\|ryP	NV3sS5d6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
DU-145	Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M32yNGlEPTB;MD60OlczQSEQvF2=	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
LB996-RCC	NYiyfnN6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MU\JR\|UxRTBwNEewOVQh\|ryP	M3PjRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
C8166	NGWx[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVzJTJlJUUN3ME2wMlQ4PCEQvF2=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
MOLT-4	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTUO4xKSzVyPUCuOFc4OzRizszN	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
DMS-53	M2nOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV\pR4p4UUN3ME2wMlQ4QDB7IN88US=>	NGfMS2k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
TE-5	NIf0TnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH;jeVZKSzVyPUCuOFg{ODVizszN	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
KYSE-520	MlzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHPqNmhKSzVyPUCuOFg{PDNizszN	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
Detroit562	M4m4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnziTWM2OD1yLkS4PFYh\|ryP	NETNXG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SIMA	NHv4SoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoL3TWM2OD1yLkS5OFE4KM7:TR?=	NFzvR209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
NCI-H1651	NVrFVZE1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LWRmlEPTB;MD60PVY4KM7:TR?=	NF;tO\|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
HCC1599	NXPCOGNLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUXJR\|UxRTBwNEm5OVUh\|ryP	NHv3V\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
ABC-1	M13pZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnTkTWM2OD1yLkWwOFk3KM7:TR?=	NH;YVII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
CAL-33	NFWwOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LkW2lEPTB;MD61NFg1PCEQvF2=	M1fz[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
OPM-2	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVnJR\|UxRTBwNUC5N\|ch\|ryP	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
RPMI-7951	M1TqPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmO1TWM2OD1yLkWwPVU4KM7:TR?=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
HT-1080	NW\6[IxWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHn5[\|NKSzVyPUCuOVEyOTlizszN	NXnRVVVqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
LC4-1	NVnKc4ViT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX3JR\|UxRTBwNUG0NFMh\|ryP	NW\3S3ByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
OVCAR-3	M1XTNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlHjTWM2OD1yLkWxOVch\|ryP	MnH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
CAPAN-1	NYLMb5R{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{CyfWlEPTB;MD61NlI5QCEQvF2=	NVXaTXprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
SK-OV-3	MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoDDTWM2OD1yLkWyOFM1KM7:TR?=	NY\iRXRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HuP-T3	NIHD[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVHVUYNMUUN3ME2wMlUzQDJ5IN88US=>	MoLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H838	MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3TSU2lEPTB;MD61Nlg1QSEQvF2=	Mke5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
K5	M2nV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwNUOyNFEh\|ryP	NXi5PZZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
CAL-72	NVTzXI1pT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTBwNUOzPFch\|ryP	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NH-12	MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPYT5RSUUN3ME2wMlU{QTV7IN88US=>	NHjxPFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SNB75	NH2xNoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\TXYlKSzVyPUCuOVU4OyEQvF2=	NWjZc3JKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
BPH-1	NYPhRWc6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV\JR\|UxRTBwNU[zOFQh\|ryP	MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
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NCI-H2052	MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwNU[3OFEh\|ryP	MlGwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
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NCI-H1703	NED2WJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTBwNUm0Nlch\|ryP	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
UACC-257	MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGHLeG9KSzVyPUCuOVk1QDdizszN	NVnldFB7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
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MHH-CALL-2	NEPlNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUjJR\|UxRTBwNkC4PFgh\|ryP	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
ChaGo-K-1	MmroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFv6VJhKSzVyPUCuOlEzOjlizszN	M3TPcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
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Capan-2	NWjXRot[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDKPIVuUUN3ME2wMlY3PjJ{IN88US=>	NX\qXVdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HSC-4	NXz5XZo2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlfjTWM2OD1yLk[2Olk5KM7:TR?=	NFPzcmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
COLO-824	M1\Ie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXrJR\|UxRTBwNke4NlMh\|ryP	NFLMeVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
NCI-H2170	M4XQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFKwUFRKSzVyPUCuOlgzPThizszN	M{X1PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
GDM-1	NIWyd49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvONppJUUN3ME2wMlY5PDl2IN88US=>	MnrVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
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VA-ES-BJ	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXVTWM2OD1yLk[5PVg3KM7:TR?=	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
KM-H2	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4LpS2lEPTB;MD63NFA6OSEQvF2=	NWP0WFhtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HH	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVfJR\|UxRTBwN{C2OlIh\|ryP	MkDiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
DK-MG	NWXKVXRVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlrYTWM2OD1yLkexNFE3KM7:TR?=	NEjSSFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
VM-CUB-1	MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2HCUWlEPTB;MD63NVI2QSEQvF2=	NIfkdng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
COLO-829	MmjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLKTWM2OD1yLkexPVg2KM7:TR?=	MnHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
OMC-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX\CcIdKUUN3ME2wMlczOTB2IN88US=>	NXH5VVVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
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NCI-H28	M3rtVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUn1fJlEUUN3ME2wMlc1ODh\|IN88US=>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
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LB2241-RCC	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2f3eWlEPTB;MD63OlA5PyEQvF2=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
CCRF-CEM	M2X5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmjETWM2OD1yLke3NFUzKM7:TR?=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
NCI-H510A	M4rGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXLx[nFbUUN3ME2wMlc4OTh4IN88US=>	MljwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
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NCI-H2081	NIrIO3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXzQWpdGUUN3ME2wMlc5OTR5IN88US=>	NHjW[YY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
RMG-I	NFThTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVHhW5dFUUN3ME2wMlc5OjF{IN88US=>	NFr1eIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
LU-99A	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTBwN{i0NVMh\|ryP	NXLnU\|Q6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
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MDA-MB-231	NWSxXohTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFnEWXdKSzVyPUCuPFAyOzFizszN	Mlj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
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MDA-MB-157	NEHXcYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUC1dpNHUUN3ME2wMlgzOjdzIN88US=>	NGX6PGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
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NCI-H23	MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV3JR\|UxRTFyLk[0OFIh\|ryP	NVnsRpJVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
UACC-812	NILFWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXHJR\|UxRTFzLkexO{DPxE1?	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
SCLC-21H	M13PNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUf1bXRNUUN3ME2xNk4yPTVzIN88US=>	NVe0[IFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
NCI-SNU-16	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYDnd4NPUUN3ME2xN{4yOjV6IN88US=>	NUXZRWpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
HD-MY-Z	MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYDJR\|UxRTF2Lk[zOlMh\|ryP	Mn:5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
SK-N-FI	NFTXSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEPmfm1KSzVyPUG0Mlg6OTJizszN	MkDoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
LB647-SCLC	MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIX3XoNKSzVyPUG1MlcyQTVizszN	NYjJc4tDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
NCI-H345	NYPyOHhZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX;JR\|UxRTF5LkO0N{DPxE1?	Mm\JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H1563	NV7XVnFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mmi5TWM2OD1zOD63OlAyKM7:TR?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNVA4OzV6Lze+V2FPT0WUPD;hQi=>
RL	Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTJzLkK2OVYh\|ryP	NXLQRnU3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
KY821	M1S4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmHvTWM2OD1{Mj6wOVU{KM7:TR?=	M3HycVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
JVM-3	NYf4VY9IT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4P2UmlEPTB;MkWuNFQyOyEQvF2=	M2T1cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H1793	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmPFTWM2OD1{OD61OFk6KM7:TR?=	Mle2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
LU-134-A	MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmH6TWM2OD1\|MD6yNFM4KM7:TR?=	M{LW[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
NCI-H1395	NYPxS4dqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mm\2TWM2OD1\|Mj6yOFMyKM7:TR?=	NYT6dHBDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
NCI-H1993	MkPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3;y[2lEPTB;M{KuPFIyQCEQvF2=	NEDlTVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
P31-FUJ	M3;OdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkTuTWM2OD1\|Mz60PFk6KM7:TR?=	MmrlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
LS-513	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NW\iS2M6UUN3ME2zOU45QDd7IN88US=>	NHvGWmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
SK-MEL-1	NIHxOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4rDTmlEPTB;NECuN\|Q6QSEQvF2=	MlHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
SW684	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MorNTWM2OD12Mz65OlYyKM7:TR?=	M123RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIyODd\|NUivK\|5USU6JRWK8M4E,
COR-L88	Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkK5TWM2OD12ND6wOlY2KM7:TR?=	MkT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlExPzN3OD:nQnNCVkeHUkyvZV4>
NCI-H889	MljrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEDjb3NKSzVyPUS1MlAxQDdizszN	NXfMSoh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjFyN{O1PE8oRlODTlfFVlww[T5?
TALL-1	M4XXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{TkOmlEPTB;NE[uNVE6QSEQvF2=	NIn3UJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?
KARPAS-299	M3OwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYm4N2ZSUUN3ME20O{4yQTl\|IN88US=>	NE\vXoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOTB5M{W4M{c,W0GQR1XSQE9iRg>?

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cyclin D1 / p27 Kip1 ; PubMed: 28382170 Theranostics Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1. p-Cyclin D1 ; PubMed: 28035994 Int J Mol Sci Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control; p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; PubMed: 28035994 Int J Mol Sci Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;	28382170 28035994
Growth inhibition assay	Cell proliferation ; PubMed: 28035994 Int J Mol Sci Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control. Cell viability; PubMed: 21368880 Cell Death Dis H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D.	28035994 21368880

In vivo

Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. ^[1]

Protocol

Kinase Assay:^[1]	- Collapse Bcl-2 Binding affinity calculation: A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. ^[4] As a control in determining the reliability of the calculation, predicted binding affinities K_i) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:^[2]	- Collapse Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) Concentrations: ~10 μM Incubation Time: 48-72 hours Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 10⁴ per well for HMCLs or 5~10 × 10³ for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined. (Only for Reference)
Animal Research:^[1]	- Collapse Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used. Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg Administration: Administered intravenously (tail vein) once a day (Only for Reference)

References

[4] Naim M, et al. J Chem Inf Model, 2007, 47(1), 122-133.

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Solubility (25°C)

In vitro	DMSO	83 mg/mL (200.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Obatoclax Mesylate (GX15-070) SDF

Molecular Weight	413.49
Formula	C₂₀H₁₉N₃O.CH₄O₃S
CAS No.	803712-79-0
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
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Molecular Weight Calculator

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00438178	Completed	Drug: Obatoclax mesylate (GX15-070MS)	Hematological Malignancies	Gemin X\|Teva Pharmaceutical Industries	October 2005	Phase 1
NCT00600964	Completed	Drug: GX15-070MS	Chronic Lymphocytic Leukemia	Gemin X\|Teva Pharmaceutical Industries	September 2004	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Bcl-2 Signaling Pathway Map

Bcl-2 Inhibitors with Unique Features

Pan Bcl-2 Inhibitor

ABT-737 : Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.
Most Potent Bcl-2 Inhibitor

ABT-263 (Navitoclax) : Bcl-xL, K_i≤ 0.5 nM; Bcl-2, K_i≤ 1 nM; Bcl-w, K_i≤ 1 nM.
Classic Bcl-2 Inhibitor

ABT-737 : BH3-mimetic inhibitor, Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.

Related Bcl-2 Products

MI-773 (SAR405838) ^New

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Navitoclax (ABT-263)

Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with K_i of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
Venetoclax (ABT-199)

Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with K_i of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3.

Features:Re-engineered version of ABT-263 (Navitoclax).
ABT-737

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
Sabutoclax

Sabutoclax (BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
(R)-(-)-Gossypol acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

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Obatoclax Mesylate (GX15-070)