Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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Cited by 70 Publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfBSVRCUUN3ME2wMlAxODB|MUeg{txO MmTCV2FPT0WU
SK-MEL-30 MkXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMECwN|U2KM7:TR?= MVnTRW5ITVJ?
NALM-6 NUDPPFlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HEfWlEPTB;MD6wNFA{PTZizszN MonGV2FPT0WU
KYSE-450 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\ZTWM2OD1yLkCwNFQ3QSEQvF2= NVnwZY8{W0GQR1XS
BHY M1q4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jlTGlEPTB;MD6wNFA3ODFizszN NX7Wcmc2W0GQR1XS
GR-ST MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\JdYhKSzVyPUCuNFAxPjR6IN88US=> MXXTRW5ITVJ?
786-0 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjRc5dQUUN3ME2wMlAxODd5NjFOwG0> MUPTRW5ITVJ?
C-33-A NVLRTXB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXiXnBkUUN3ME2wMlAxODh2ODFOwG0> NGLEcnZUSU6JRWK=
BHT-101 NHzlemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[3eXllUUN3ME2wMlAxOTB4IN88US=> MWfTRW5ITVJ?
EB2 NYTiWZRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTGem5KSzVyPUCuNFAyOThizszN Mn3zV2FPT0WU
G-361 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TPfGlEPTB;MD6wNFEzPCEQvF2= NIHuO21USU6JRWK=
KE-37 M3TU[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfxSGlWUUN3ME2wMlAxOTJ6IN88US=> Mni5V2FPT0WU
MHH-PREB-1 NFTjRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPLTWM2OD1yLkCwNVQh|ryP M1rHcnNCVkeHUh?=
MCF7 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX6TXpjUUN3ME2wMlAxOTV7IN88US=> M2OzUXNCVkeHUh?=
LOUCY NEPJNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYeyTmxoUUN3ME2wMlAxOTd3IN88US=> MVnTRW5ITVJ?
EW-7 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknHTWM2OD1yLkCwNVc2KM7:TR?= MmrjV2FPT0WU
KYSE-510 NHi5PJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Xlb2lEPTB;MD6wNFI{OyEQvF2= MlfHV2FPT0WU
SK-MEL-3 NVj5UZRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETXdW5KSzVyPUCuNFAzPjRizszN MVfTRW5ITVJ?
HAL-01 MoTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnodJpKSzVyPUCuNFAzQTdizszN NVP4PYxjW0GQR1XS
HCC2998 NFLpc3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMECzN|Uh|ryP MUnTRW5ITVJ?
A375 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXqTWM2OD1yLkCwN|Uh|ryP NHfUT5ZUSU6JRWK=
MZ7-mel NXvXR5JQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTWW|VKSzVyPUCuNFA{QTlizszN NHniNJBUSU6JRWK=
SH-4 NFfZTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEC0NVch|ryP NXiycVFHW0GQR1XS
HT-144 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPTfm93UUN3ME2wMlAxPDNizszN NWXE[VB[W0GQR1XS
KYSE-140 NVKxRYs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;2c49KSzVyPUCuNFA1OzVizszN MmSxV2FPT0WU
PSN1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1KwNmlEPTB;MD6wNFQ3PyEQvF2= M3TVfnNCVkeHUh?=
COLO-679 NXz5OGdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEC0PVgh|ryP NH7JbItUSU6JRWK=
SW620 NXnXTppST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nTemlEPTB;MD6wNFUyOSEQvF2= MY\TRW5ITVJ?
HGC-27 NUH1TGRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjLfIVKSzVyPUCuNFA2OjRizszN MYfTRW5ITVJ?
IGROV-1 NYq3UFdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEC2JO69VQ>? MXrTRW5ITVJ?
IGR-1 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf0TWM2OD1yLkCwOlAyKM7:TR?= MkW4V2FPT0WU
EW-1 NFWzUVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEC2OVEh|ryP MmrwV2FPT0WU
769-P NFLLZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTpTWM2OD1yLkCwOlc5KM7:TR?= M1fmfXNCVkeHUh?=
HN M33yNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDST2NKSzVyPUCuNFA3PzlizszN Mmr3V2FPT0WU
SIG-M5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmS0TWM2OD1yLkCwO|Eh|ryP MmLZV2FPT0WU
IST-MEL1 NVXTVJZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEC4NVgh|ryP MonGV2FPT0WU
ST486 MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEC4NlUh|ryP NXG5SlA6W0GQR1XS
ES7 NEfJTHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMEC4OFYh|ryP M33LWnNCVkeHUh?=
GAK M3r3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe3[JhKSzVyPUCuNFA5PDhizszN M1PiWHNCVkeHUh?=
BB30-HNC NIrZUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rWZWlEPTB;MD6wNFg2QCEQvF2= NEfDWJRUSU6JRWK=
IPC-298 MkmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjaTG1xUUN3ME2wMlAxQTJ5IN88US=> M1fse3NCVkeHUh?=
NKM-1 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEC5O|Ih|ryP NWLEZoJ6W0GQR1XS
RKO NHu0PXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnITWM2OD1yLkCxNFQ1KM7:TR?= MoPnV2FPT0WU
ACN MkD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jyS2lEPTB;MD6wNVE{OSEQvF2= Ml3iV2FPT0WU
SW1417 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELMeZlKSzVyPUCuNFEzOjVizszN NWiyRolYW0GQR1XS
SR NV;2dI5HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TifGlEPTB;MD6wNVI{PSEQvF2= NGq2b|hUSU6JRWK=
SNG-M MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nCWGlEPTB;MD6wNVMyPyEQvF2= MmnDV2FPT0WU
CAL-12T M{Duc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[4cGdKSzVyPUCuNFE{PDZizszN MlP6V2FPT0WU
HSC-3 M33vc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEGzOVUh|ryP NYXPTYI5W0GQR1XS
DOHH-2 NWizWHF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEG0NVIh|ryP NUfYcmpEW0GQR1XS
NB69 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEG1OlUh|ryP MmfiV2FPT0WU
LC-2-ad MknLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\kOlYxUUN3ME2wMlAyPThzIN88US=> NV;YdHYzW0GQR1XS
RVH-421 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2myOWlEPTB;MD6wNVY4PCEQvF2= NGWxdYlUSU6JRWK=
TGW MoHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fIWWlEPTB;MD6wNVc{QSEQvF2= NXW4ZYNqW0GQR1XS
HCC1569 NEPRdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq5SFNKSzVyPUCuNFE4QTdizszN MWDTRW5ITVJ?
CAL-85-1 NFLUPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPPTWM2OD1yLkCxPFMzKM7:TR?= NFm0VWFUSU6JRWK=
RPMI-8402 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrZTWM2OD1yLkCxPFU5KM7:TR?= Mn3PV2FPT0WU
THP-1 NFe5PJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn6R4dKSzVyPUCuNFE6QThizszN NX3NfnNKW0GQR1XS
ONS-76 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnvTWM2OD1yLkCyNFM3KM7:TR?= NEjGe3ZUSU6JRWK=
A2780 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEKwO|kh|ryP NGricpBUSU6JRWK=
RPMI-2650 NY\RWlB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q2RmlEPTB;MD6wNlI6PiEQvF2= MmDCV2FPT0WU
MEL-HO M{DqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPIPWNKSzVyPUCuNFI{PDhizszN Mlz2V2FPT0WU
MC-CAR MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XtT2lEPTB;MD6wNlM2PiEQvF2= NYXDfJVDW0GQR1XS
HSC-2 NWfnZpk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT6TWM2OD1yLkCyOFY3KM7:TR?= NIO1bGJUSU6JRWK=
MEL-JUSO M2f4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjyXG1ZUUN3ME2wMlAzPDd|IN88US=> M{\0O3NCVkeHUh?=
CAL-62 NE\TTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEK2NFIh|ryP M2jPbHNCVkeHUh?=
DMS-273 NGPsPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnL2TWM2OD1yLkCyPFQ4KM7:TR?= MlHiV2FPT0WU
S-117 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX34VoMzUUN3ME2wMlAzQTB4IN88US=> MYLTRW5ITVJ?
SUP-T1 NHrCc4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrWZmVKSzVyPUCuNFI6PDlizszN NXvSUXBJW0GQR1XS
MZ2-MEL Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEK5OVkh|ryP NUL3Rm9TW0GQR1XS
KYSE-270 NUmyOYZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfnO5VKSzVyPUCuNFI6PzZizszN M{naZXNCVkeHUh?=
CMK MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWntW2xEUUN3ME2wMlA{ODJ|IN88US=> NXnqTGFHW0GQR1XS
8505C NF3GOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPQW3dKSzVyPUCuNFMxPCEQvF2= MVjTRW5ITVJ?
NUGC-3 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfLco11UUN3ME2wMlA{ODR6IN88US=> MoTXV2FPT0WU
A101D MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfKTWM2OD1yLkCzNFU2KM7:TR?= MYjTRW5ITVJ?
G-401 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEOwPVMh|ryP NXzs[VlIW0GQR1XS
OVCAR-8 NF;tVItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT1TWM2OD1yLkCzNVA4KM7:TR?= NXHpfXhCW0GQR1XS
IMR-5 MoexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XEWGlEPTB;MD6wN|I1PCEQvF2= NWXWcppmW0GQR1XS
DoTc2-4510 NVPkZXE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml60TWM2OD1yLkCzN|k{KM7:TR?= NV7aeGp5W0GQR1XS
HOS NXHXeFZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq1TWM2OD1yLkCzOFc{KM7:TR?= NETvXXNUSU6JRWK=
HEC-1 NFvmN2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnjRpVKSzVyPUCuNFM3QCEQvF2= NHHWVW9USU6JRWK=
SW756 NELWcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7KVnBKSzVyPUCuNFM5OjFizszN MoLsV2FPT0WU
NCI-H64 NFzIUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEO4OFIh|ryP NVLzPXlLW0GQR1XS
EW-16 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMEO5NFkh|ryP NG\lTGNUSU6JRWK=
CAL-51 MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofJTWM2OD1yLkC0NFA2KM7:TR?= M1TS[3NCVkeHUh?=
KYSE-150 M3v4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnqc2pKSzVyPUCuNFQxOTFizszN MmDSV2FPT0WU
SW1710 NVfuWmZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPrOXlKSzVyPUCuNFQxOThizszN NH\0TmhUSU6JRWK=
HuP-T4 NFn6dW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEW5[mxKSzVyPUCuNFQyOThizszN NXn6eIZtW0GQR1XS
LB373-MEL-D Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\MeJFKSzVyPUCuNFQzOzJizszN NWPUS3FXW0GQR1XS
EW-13 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW2NlBKSzVyPUCuNFQ1ODZizszN NXP2b5dWW0GQR1XS
HT-29 M4\2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMES0PUDPxE1? MXjTRW5ITVJ?
SCC-25 NWiwenBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\PRphTUUN3ME2wMlA1PDl2IN88US=> NI[2b|FUSU6JRWK=
REH MoX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMES2N|Uh|ryP NVS0d|FTW0GQR1XS
L-363 NFX0UoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMES2O|kh|ryP M1LJfHNCVkeHUh?=
NCI-H1770 NXO4WYxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjIdpZKSzVyPUCuNFQ3QTdizszN NFj4PHJUSU6JRWK=
CHL-1 M4DTUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMES4OVch|ryP NYLrPHgyW0GQR1XS
ES1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LHVWlEPTB;MD6wOFg5PSEQvF2= M4TaPXNCVkeHUh?=
SCC-15 NXPRW|BsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMES5NFIh|ryP MYHTRW5ITVJ?
MRK-nu-1 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;ZS2lEPTB;MD6wOFk{PiEQvF2= NGnvcVVUSU6JRWK=
PF-382 M1;CTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES3U2ZKSzVyPUCuNFQ6OzlizszN MmfWV2FPT0WU
COLO-680N NEi5bnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPaTWM2OD1yLkC1NFQ4KM7:TR?= NGPW[IVUSU6JRWK=
LK-2 M1rJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH6TWM2OD1yLkC1NFY{KM7:TR?= NHvLNGtUSU6JRWK=
NCI-H2342 NGfudVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Hqe2lEPTB;MD6wOVEyPyEQvF2= MlPwV2FPT0WU
HMV-II MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z0bmlEPTB;MD6wOVI{QSEQvF2= NVLBVJc6W0GQR1XS
PC-14 NEDBNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTtNYVbUUN3ME2wMlA2OjV{IN88US=> NFnMTo1USU6JRWK=
COLO-320-HSR Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ZTWM2OD1yLkC1Nlg6KM7:TR?= MXHTRW5ITVJ?
697 M3XyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEWzNlMh|ryP MY\TRW5ITVJ?
NEC8 NIDTdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHYeFI1UUN3ME2wMlA2PTlizszN M3jYOXNCVkeHUh?=
LCLC-97TM1 NH\Fd3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLFXFZkUUN3ME2wMlA2PTl2IN88US=> M2n5ZXNCVkeHUh?=
Daoy MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXqTWM2OD1yLkC1OlE3KM7:TR?= MnT3V2FPT0WU
ETK-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37GTGlEPTB;MD6wOVY4OiEQvF2= M{DNS3NCVkeHUh?=
A388 NG\rZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LU[2lEPTB;MD6wOVY6PSEQvF2= MWnTRW5ITVJ?
COLO-205 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PvS2lEPTB;MD6wOVcyPiEQvF2= MmLnV2FPT0WU
SK-PN-DW NULMZ4lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q4eWlEPTB;MD6wOVczQSEQvF2= MVfTRW5ITVJ?
SF268 M{fJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLITWM2OD1yLkC1O|U3KM7:TR?= M3zlOXNCVkeHUh?=
OCI-AML2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6zcmtXUUN3ME2wMlA2Pzd5IN88US=> NUfnZZliW0GQR1XS
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EB-3 M2\tXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nB[WlEPTB;MD6xO|MyKM7:TR?= M3GwVXNCVkeHUh?=
HCC1143 M{fEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDiTWM2OD1yLkG3N|k3KM7:TR?= M{fm[3NCVkeHUh?=
DJM-1 M3jWTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2P6b2lEPTB;MD6xO|Q2OSEQvF2= NXnq[G1XW0GQR1XS
BT-474 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\OTWM2OD1yLkG3OFg6KM7:TR?= MnnuV2FPT0WU
BB65-RCC NWHpSmZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUe1OFUh|ryP MkizV2FPT0WU
NCI-H292 NFXjZXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjHTWM2OD1yLkG3OlAyKM7:TR?= NXnNTWJQW0GQR1XS
MKN28 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMUe2OVMh|ryP M4\Me3NCVkeHUh?=
TK10 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXt[VFKSzVyPUCuNVc4ODJizszN NHu1dldUSU6JRWK=
TYK-nu MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPiT2lZUUN3ME2wMlE4QTR7IN88US=> MnvsV2FPT0WU
8305C NYfieYlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jjeWlEPTB;MD6xO|k4OSEQvF2= MVHTRW5ITVJ?
MV-4-11 M17ENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMUe5O|ch|ryP M17xcHNCVkeHUh?=
NCI-H522 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3zTWM2OD1yLkG4NFk1KM7:TR?= M2T0[nNCVkeHUh?=
Hs-578-T NUO5[VVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMUiyPVIh|ryP NUjMfWFZW0GQR1XS
LCLC-103H MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK0TWM2OD1yLkG4OVI4KM7:TR?= NFHTOWlUSU6JRWK=
MHH-ES-1 M1;hUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq0T2NKSzVyPUCuNVg3OjlizszN MmTlV2FPT0WU
NCI-H441 NUjH[25LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrISYFQUUN3ME2wMlE6OTR6IN88US=> NUXkPYp3W0GQR1XS
AM-38 NGDac4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r1R2lEPTB;MD6xPVIzPSEQvF2= NX3IdVlOW0GQR1XS
SW1783 NXTwWWNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV62fVF6UUN3ME2wMlE6OzB3IN88US=> NGXaOWRUSU6JRWK=
SK-HEP-1 M2Xac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMUm2N|ch|ryP M1\XZ3NCVkeHUh?=
OAW-28 MlnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\TUXpKSzVyPUCuNlAyPzhizszN NYXlfFd4W0GQR1XS
TE-15 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PYcWlEPTB;MD6yNFI2OiEQvF2= NIXHfVhUSU6JRWK=
HCE-4 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r3V2lEPTB;MD6yNFI5PCEQvF2= MmXTV2FPT0WU
JiyoyeP-2003 NYW3XmZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTBwMkCzN|Yh|ryP MUPTRW5ITVJ?
OVCAR-4 MnLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTsTWM2OD1yLkKwOlI5KM7:TR?= NHz6boNUSU6JRWK=
SNU-449 NUPudodmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rFbGlEPTB;MD6yNFc6PyEQvF2= M4XqNHNCVkeHUh?=
SBC-5 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\OUmNKSzVyPUCuNlEzOTVizszN MkXHV2FPT0WU
T84 NVu4SWtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\RTVhFUUN3ME2wMlIyOjR6IN88US=> MXHTRW5ITVJ?
LP-1 Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nQPGlEPTB;MD6yNVMxOiEQvF2= M4Ly[HNCVkeHUh?=
MG-63 M1rrO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvRS4k2UUN3ME2wMlIyOzh{IN88US=> NX\vdpVXW0GQR1XS
OAW-42 NV7DO3B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom4TWM2OD1yLkKxOFc5KM7:TR?= NX3n[pc4W0GQR1XS
L-540 M4foXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nreWlEPTB;MD6yNVU6QCEQvF2= NHfJV|ZUSU6JRWK=
RH-1 NX;qR2lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LPb2lEPTB;MD6yNlI1OiEQvF2= MlvpV2FPT0WU
HCT-15 NWfVbmVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO0T4JKSzVyPUCuNlI1QDRizszN M2joTnNCVkeHUh?=
OCUB-M MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjRe3lUUUN3ME2wMlIzPDh6IN88US=> M{DlOnNCVkeHUh?=
GP5d MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDU[plKSzVyPUCuNlI2OjhizszN MmH6V2FPT0WU
NCI-H2030 NYfPTWNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rIN2lEPTB;MD6yNlc{PCEQvF2= MVnTRW5ITVJ?
ML-2 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMkK4PFkh|ryP M{PGO3NCVkeHUh?=
CAL-39 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zndWlEPTB;MD6yNlk{PiEQvF2= M3zWVXNCVkeHUh?=
MIA-PaCa-2 M{LFfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fVcmlEPTB;MD6yN|I5PyEQvF2= MkKyV2FPT0WU
TE-9 M1i4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;tTWM2OD1yLkKzN|Ih|ryP NH7FS2ZUSU6JRWK=
LB2518-MEL NFztVZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMkOzO|Ih|ryP NGXSeXRUSU6JRWK=
DB MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\JWVNOUUN3ME2wMlI{PDN6IN88US=> NU\VXWZHW0GQR1XS
NCI-H596 M{\lWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMkO1O|Eh|ryP Mo[2V2FPT0WU
SW1990 NFvGSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:5eIpKSzVyPUCuNlM6PDZizszN MWrTRW5ITVJ?
P30-OHK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMkSwOUDPxE1? Mk\4V2FPT0WU
ALL-PO NW\vbW5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMkSxOlkh|ryP NUjxdHZPW0GQR1XS
Saos-2 NF7FdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFr6bo1KSzVyPUCuNlQ2PzFizszN M2D2c3NCVkeHUh?=
MFH-ino NU\GOIppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uxXWlEPTB;MD6yOFY6OiEQvF2= NF3hOmtUSU6JRWK=
OE33 M3HBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXCTWM2OD1yLkK1NVEh|ryP MmnOV2FPT0WU
Calu-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMkWyPVch|ryP MUPTRW5ITVJ?
HT M4LVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPSTWM2OD1yLkK1OlIyKM7:TR?= MorFV2FPT0WU
LXF-289 M2TnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj1NndSUUN3ME2wMlI2QTh2IN88US=> MnntV2FPT0WU
KGN M1G3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7vcFE6UUN3ME2wMlI3ODh7IN88US=> MmK5V2FPT0WU
NCI-H1417 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMk[1NlQh|ryP Mm\6V2FPT0WU
SF126 NVjTT2xMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMkezNFIh|ryP NHXHT2JUSU6JRWK=
SAS NWL1SYp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP2TWM2OD1yLkK3N|A5KM7:TR?= NX\DOW1SW0GQR1XS
22RV1 NYXHWG5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTBO3BHUUN3ME2wMlI4Ozd6IN88US=> NHT4b2xUSU6JRWK=
GI-1 NWXqRppnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TWc2lEPTB;MD6yO|Q5PyEQvF2= MV\TRW5ITVJ?
ES3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHlbZFrUUN3ME2wMlI4PzZ|IN88US=> M{POVHNCVkeHUh?=
NB1 NViwcotnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPQRmcxUUN3ME2wMlI4QDd4IN88US=> MX\TRW5ITVJ?
NCI-H650 MmfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkizNFIh|ryP NFvxOI5USU6JRWK=
IST-MES1 NInVR|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO3UY9KSzVyPUCuNlg2PTRizszN M3PaN3NCVkeHUh?=
UM-UC-3 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT2So1KSzVyPUCuNlkyPCEQvF2= M{D2SXNCVkeHUh?=
CAL-120 M4jRT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\2TWlEPTB;MD6yPVY{OSEQvF2= MnTqV2FPT0WU
UACC-62 MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHnTWM2OD1yLkOwNlQyKM7:TR?= MWjTRW5ITVJ?
TE-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwM{CyOFkh|ryP MWXTRW5ITVJ?
MKN1 NHPMe4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW1TWM2OD1yLkOwN|Yh|ryP NFLPNG1USU6JRWK=
KS-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v0SGlEPTB;MD6zNFUzPiEQvF2= NWDmcmJQW0GQR1XS
GCIY MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwM{GwNFIh|ryP NIDpbIFUSU6JRWK=
OVCAR-5 M{myNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwM{GxNFYh|ryP NFLLU5ZUSU6JRWK=
U-266 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13FVWlEPTB;MD6zNVE1PyEQvF2= M4nrPHNCVkeHUh?=
Calu-1 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfx[GZKSzVyPUCuN|EzQDlizszN MVTTRW5ITVJ?
SK-LMS-1 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjVW4V{UUN3ME2wMlMyPDJ7IN88US=> MnOzV2FPT0WU
COLO-741 NF\icG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvjTWM2OD1yLkOxOlE1KM7:TR?= NWLCXnh{W0GQR1XS
RPMI-8226 M4HhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwM{G2OFEh|ryP NVyw[45uW0GQR1XS
KM12 NV\QZYhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\aTWM2OD1yLkOxPFMh|ryP M2TRUXNCVkeHUh?=
NMC-G1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37wPGlEPTB;MD6zNVg3KM7:TR?= MVHTRW5ITVJ?
SJRH30 MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT1[GQxUUN3ME2wMlMzODV{IN88US=> M4HuWHNCVkeHUh?=
COR-L105 NVP4OGdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHaW3RKSzVyPUCuN|IzOThizszN M1u2UXNCVkeHUh?=
IM-9 NHTEVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHns[mRKSzVyPUCuN|MxOjFizszN NVL6bWl{W0GQR1XS
TE-12 M1rCUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXTVWZGUUN3ME2wMlM{OzF5IN88US=> NVvLfW8zW0GQR1XS
KG-1 NXf0d3J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe4TWM2OD1yLkOzOFMzKM7:TR?= NUnGVmFPW0GQR1XS
U251 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwM{O0OVYh|ryP M2TFT3NCVkeHUh?=
EFO-27 M2j4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojETWM2OD1yLkOzPVUyKM7:TR?= M1jMRXNCVkeHUh?=
EW-24 MonMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwM{O5PFQh|ryP M{fr[XNCVkeHUh?=
SF295 NGnYVmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwM{O5PVkh|ryP NIL0OGpUSU6JRWK=
MC-IXC MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPjTWM2OD1yLkO0OUDPxE1? MmG0V2FPT0WU
NCI-H2405 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\wbWlEPTB;MD6zOFc{OiEQvF2= NEDYOmRUSU6JRWK=
NCI-H2009 NWPOeo1mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{S3N|kh|ryP MWrTRW5ITVJ?
LB1047-RCC NHLHcHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXSTWM2OD1yLkO1PFE2KM7:TR?= M1T0dHNCVkeHUh?=
KNS-81-FD NV3sZ|ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH1NnRKSzVyPUCuN|Y3PjdizszN M2rMO3NCVkeHUh?=
HOP-92 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLHNmhKSzVyPUCuN|Y5OyEQvF2= MoX4V2FPT0WU
L-428 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHnXXV2UUN3ME2wMlM4ODF4IN88US=> M3rGSnNCVkeHUh?=
C3A NGLGe5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnThTWM2OD1yLkO3N|c6KM7:TR?= NFvMcJZUSU6JRWK=
NCI-H1792 NVfQUmo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnrcoJ2UUN3ME2wMlM4PjV3IN88US=> MkXjV2FPT0WU
HuH-7 MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\CU2NbUUN3ME2wMlM4QTFizszN M{jsbXNCVkeHUh?=
AGS NVzqUpNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H1WGlEPTB;MD6zPFY{QCEQvF2= Mke2V2FPT0WU
HT-1197 NWK2UIlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Oz[2lEPTB;MD6zPVQ3KM7:TR?= M{X2bXNCVkeHUh?=
CGTH-W-1 NE\XVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XFbmlEPTB;MD6zPVkyOyEQvF2= NYntR3l5W0GQR1XS
KNS-42 NGW4OINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNECwOFUh|ryP M17CU3NCVkeHUh?=
HuO-3N1 M3zSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC2TWM2OD1yLkSwNFU2KM7:TR?= MoTHV2FPT0WU
VMRC-RCZ NHjnSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXMVFI1UUN3ME2wMlQxOzB|IN88US=> NXPhVJNDW0GQR1XS
SW954 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwNECzN|Uh|ryP NGKy[FNUSU6JRWK=
MES-SA M{[wOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNEC1NFUh|ryP MkTSV2FPT0WU
Ca-Ski NGjsR4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PBWGlEPTB;MD60NFUzPCEQvF2= M2PKfXNCVkeHUh?=
SW13 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\BNHh[UUN3ME2wMlQxPjJ4IN88US=> MkXRV2FPT0WU
NCI-H1437 NUjGblF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\sTWM2OD1yLkSwPFA2KM7:TR?= NE\UUVFUSU6JRWK=
U-118-MG Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;CSI1VUUN3ME2wMlQxQTB2IN88US=> NV24PFlWW0GQR1XS
NCI-H1734 NFrteGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MormTWM2OD1yLkSyNFE{KM7:TR?= NIfFdHlUSU6JRWK=
HDLM-2 NUPiXYJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwNEKwN|Mh|ryP NIrQXopUSU6JRWK=
AU565 NFLsRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnxeIlXUUN3ME2wMlQzPDZ6IN88US=> Mn:yV2FPT0WU
FADU M1Hk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwNEK2OFkh|ryP NFzPPHpUSU6JRWK=
OS-RC-2 NF7WV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjqOm92UUN3ME2wMlQ{ODh|IN88US=> NVPSUFY5W0GQR1XS
CAMA-1 M{PSPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLUTWM2OD1yLkSzOlI3KM7:TR?= M2XsUnNCVkeHUh?=
MONO-MAC-6 M3LQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITsXZBKSzVyPUCuOFM5PDlizszN MojkV2FPT0WU
LB831-BLC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{KzR2lEPTB;MD60OFM4OSEQvF2= MWrTRW5ITVJ?
SW982 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPNN5BKSzVyPUCuOFQ2OjhizszN M3zsNnNCVkeHUh?=
SCC-3 NVr4PXpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwNES1O|kh|ryP MorUV2FPT0WU
C32 NHy2XXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGez[YhKSzVyPUCuOFUzOjlizszN MYXTRW5ITVJ?
BFTC-909 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTDTWM2OD1yLkS1Nlk6KM7:TR?= M13PcnNCVkeHUh?=
MEG-01 M2rnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXZTWM2OD1yLkS1N|c{KM7:TR?= NU\Zdpd3W0GQR1XS
M14 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwNEW5O|kh|ryP Moj6V2FPT0WU
MPP-89 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVKyNmw6UUN3ME2wMlQ3OjV4IN88US=> NUm3VlRJW0GQR1XS
HCC1937 NWHhb5NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3ZTWM2OD1yLkS2N|g1KM7:TR?= MYnTRW5ITVJ?
SW837 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTwWJFJUUN3ME2wMlQ3PzJ{IN88US=> MU\TRW5ITVJ?
DU-145 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDabIlKUUN3ME2wMlQ3PzJ7IN88US=> MULTRW5ITVJ?
LB996-RCC NWewXGNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPSbYt7UUN3ME2wMlQ4ODV2IN88US=> NHi1dWdUSU6JRWK=
C8166 NEX4b2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PzN2lEPTB;MD60O|Qh|ryP MUTTRW5ITVJ?
MOLT-4 NGL1NVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwNEe3N|Qh|ryP NXTYZ415W0GQR1XS
DMS-53 M4roe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:yRVFKSzVyPUCuOFc5ODlizszN MoC3V2FPT0WU
TE-5 M2jvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:1dGlEPTB;MD60PFMxPSEQvF2= NF\rcoNUSU6JRWK=
KYSE-520 M32xOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNEizOFMh|ryP NH\uVGhUSU6JRWK=
Detroit562 NX3ue|d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPj[XlkUUN3ME2wMlQ5QDZizszN NFHHbVBUSU6JRWK=
SIMA MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTNTWM2OD1yLkS5OFE4KM7:TR?= MXTTRW5ITVJ?
NCI-H1651 NFfFXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfkZVVJUUN3ME2wMlQ6PjdizszN M1;6SnNCVkeHUh?=
HCC1599 M1TOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i2T2lEPTB;MD60PVk2PSEQvF2= MmjSV2FPT0WU
ABC-1 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHmTWM2OD1yLkWwOFk3KM7:TR?= MlTWV2FPT0WU
CAL-33 NVvieJNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLmb4lMUUN3ME2wMlUxQDR2IN88US=> MkHlV2FPT0WU
OPM-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M171PGlEPTB;MD61NFk{PyEQvF2= Mn;sV2FPT0WU
RPMI-7951 M2TqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrXNHdKSzVyPUCuOVA6PTdizszN NHPjNZlUSU6JRWK=
HT-1080 NXThTYY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\MZ|NKSzVyPUCuOVEyOTlizszN M3LUWHNCVkeHUh?=
LC4-1 MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwNUG0NFMh|ryP Ml7KV2FPT0WU
OVCAR-3 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\KZ2lEPTB;MD61NVU4KM7:TR?= NU\ZZ216W0GQR1XS
CAPAN-1 NEnkWWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zQSGlEPTB;MD61NlI5QCEQvF2= NF\BR5FUSU6JRWK=
SK-OV-3 NXTGcFlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlX0TWM2OD1yLkWyOFM1KM7:TR?= MmTaV2FPT0WU
HuP-T3 M3vBZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfyR5FbUUN3ME2wMlUzQDJ5IN88US=> M2O2[3NCVkeHUh?=
NCI-H838 M2C4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHWTWM2OD1yLkWyPFQ6KM7:TR?= NIj6NphUSU6JRWK=
K5 NIrXW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNUOyNFEh|ryP NVryZmZzW0GQR1XS
CAL-72 NEDCS3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG4UZRKSzVyPUCuOVM{QDdizszN MkXEV2FPT0WU
NH-12 M1LSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHzV3BEUUN3ME2wMlU{QTV7IN88US=> NULRS|FSW0GQR1XS
SNB75 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwNUW3N{DPxE1? NIn6b|lUSU6JRWK=
BPH-1 NHzXfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\KfnF3UUN3ME2wMlU3OzR2IN88US=> NX3IT5hHW0GQR1XS
NOMO-1 M4LBdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLBNIlkUUN3ME2wMlU3Ozd{IN88US=> NFTYbZhUSU6JRWK=
G-402 NW\XdIFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnPTWM2OD1yLkW2OFk6KM7:TR?= MmfUV2FPT0WU
NCI-H2052 NULhT4JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInxXnVKSzVyPUCuOVY4PDFizszN MYTTRW5ITVJ?
RCM-1 NGTxb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELydYJKSzVyPUCuOVcyPjZizszN M3H6fXNCVkeHUh?=
COR-L279 M3zDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fyTmlEPTB;MD61O|E5PSEQvF2= M3npd3NCVkeHUh?=
A253 NEXYcWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPEeFlkUUN3ME2wMlU4PTJ3IN88US=> MlrpV2FPT0WU
SK-MM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[5WXZKSzVyPUCuOVc3PzlizszN NYC1boxoW0GQR1XS
NCI-H1703 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH35bFBKSzVyPUCuOVk1OjdizszN NWPrdY9zW0GQR1XS
UACC-257 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\ETWM2OD1yLkW5OFg4KM7:TR?= NFXzU2tUSU6JRWK=
KALS-1 MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[5d2FKSzVyPUCuOlAxOTFizszN MWnTRW5ITVJ?
ES5 M{XkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfITWM2OD1yLk[wOFgh|ryP MkPsV2FPT0WU
MHH-CALL-2 NGHleYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjtSGZ7UUN3ME2wMlYxQDh6IN88US=> NFG4bWdUSU6JRWK=
ChaGo-K-1 M2radWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnflTWM2OD1yLk[xNlI6KM7:TR?= NXzYc4xuW0GQR1XS
TGBC1TKB NXewNGNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HJcWlEPTB;MD62NVk5KM7:TR?= NX;kNG5CW0GQR1XS
KU-19-19 M1;nT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nlT2lEPTB;MD62OFU5PiEQvF2= NIO5TohUSU6JRWK=
COLO-684 NHv2[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwNkW2NVEh|ryP M4LrRnNCVkeHUh?=
LS-1034 MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwNkW4NVkh|ryP Mo\hV2FPT0WU
RT-112 NVLPRVd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP1bG5WUUN3ME2wMlY3PTh5IN88US=> NVvRcnRuW0GQR1XS
Capan-2 M1jTZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HXV2lEPTB;MD62OlYzOiEQvF2= NFXxUXdUSU6JRWK=
HSC-4 NV\pd|VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr1W|VKSzVyPUCuOlY3QThizszN MVTTRW5ITVJ?
COLO-824 NX34U5c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\POmUyUUN3ME2wMlY4QDJ|IN88US=> NY\NN|dyW0GQR1XS
NCI-H2170 MmfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHETWM2OD1yLk[4NlU5KM7:TR?= M{XqOXNCVkeHUh?=
GDM-1 Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwNki0PVQh|ryP M3G0S3NCVkeHUh?=
KP-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj6TWM2OD1yLk[5OVc{KM7:TR?= M2\qW3NCVkeHUh?=
VA-ES-BJ NUnmVnhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Pnd2lEPTB;MD62PVk5PiEQvF2= NHvTeWRUSU6JRWK=
KM-H2 NWKzRWo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnOTnRKSzVyPUCuO|AxQTFizszN M2XlNHNCVkeHUh?=
HH MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3GTWM2OD1yLkewOlYzKM7:TR?= MoruV2FPT0WU
DK-MG M3fu[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3xT2hiUUN3ME2wMlcyODF4IN88US=> NUK0flN1W0GQR1XS
VM-CUB-1 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTscHRKSzVyPUCuO|EzPTlizszN NHXFVXVUSU6JRWK=
COLO-829 MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L2b2lEPTB;MD63NVk5PSEQvF2= M4q2WXNCVkeHUh?=
OMC-1 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXmbWZKSzVyPUCuO|IyODRizszN NHy1UWJUSU6JRWK=
NB12 NEiyPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTXTWM2OD1yLkeyOVA1KM7:TR?= MY\TRW5ITVJ?
NCI-H28 NWe3cXpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW3TWM2OD1yLke0NFg{KM7:TR?= MkW3V2FPT0WU
A673 NIjyWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnPb3hNUUN3ME2wMlc2OTd5IN88US=> NXPRV2FEW0GQR1XS
LB2241-RCC NGrkb4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn6U2lzUUN3ME2wMlc3ODh5IN88US=> M1vpSnNCVkeHUh?=
CCRF-CEM NHfNUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HId2lEPTB;MD63O|A2OiEQvF2= NV[3emxxW0GQR1XS
NCI-H510A M2jLVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYWwc3YxUUN3ME2wMlc4OTh4IN88US=> M1TK[HNCVkeHUh?=
SW48 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml62TWM2OD1yLke3N|M{KM7:TR?= M{S4N3NCVkeHUh?=
NCI-H2081 NF;hZotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHDTWM2OD1yLke4NVQ4KM7:TR?= MYPTRW5ITVJ?
RMG-I MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvBN3lYUUN3ME2wMlc5OjF{IN88US=> NHjUO|RUSU6JRWK=
LU-99A NUjoSXVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLXNZljUUN3ME2wMlc5PDF|IN88US=> MUPTRW5ITVJ?
KP-N-YS MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwN{i5NlEh|ryP M2DRcnNCVkeHUh?=
MDA-MB-231 NV\EbXVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj4XXhKSzVyPUCuPFAyOzFizszN M2jLdXNCVkeHUh?=
U031 NHnIbGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjITWM2OD1yLkixOFI{KM7:TR?= MkDTV2FPT0WU
EVSA-T NXHsUZNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\pTWM2OD1yLkixOlczKM7:TR?= MXvTRW5ITVJ?
MDA-MB-157 MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHXPFlKSzVyPUCuPFIzPzFizszN NEPGfXVUSU6JRWK=
EHEB NXTjbmRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L2XGlEPTB;MD64NlI4PiEQvF2= MnPwV2FPT0WU
KINGS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX6TWM2OD1yLkiyOVU2KM7:TR?= M2WxOnNCVkeHUh?=
23132-87 NVvlcI1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwOEK4OFMh|ryP MmT6V2FPT0WU
EFO-21 M2jqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XuXGlEPTB;MD64OFA5QSEQvF2= MYrTRW5ITVJ?
DOK M1L2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljyTWM2OD1yLki0PEDPxE1? MU\TRW5ITVJ?
NCI-H2171 Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nYW2lEPTB;MD64OFk3KM7:TR?= Mon6V2FPT0WU
NCI-SNU-5 NYn4[o5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwOEW1O{DPxE1? NILBNXlUSU6JRWK=
SK-N-DZ MkTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fhUGlEPTB;MD64OVk1OyEQvF2= M3vtOHNCVkeHUh?=
SNU-C2B NX7DNYdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW1WVJKSzVyPUCuPFY5ODFizszN M1nXWHNCVkeHUh?=
CP66-MEL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HRZmlEPTB;MD64O|EyKM7:TR?= MXHTRW5ITVJ?
SN12C Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf0THh3UUN3ME2wMlg5PjN5IN88US=> MWrTRW5ITVJ?
A172 NGrMXpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXZO3R4UUN3ME2wMlg5Pjl6IN88US=> NWr2fJBiW0GQR1XS
NCI-H2347 M13CV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr0cHNKSzVyPUCuPFg4PTNizszN MVPTRW5ITVJ?
NCI-H2228 NIP2[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTKSJhZUUN3ME2wMlg6OzN7IN88US=> NVzCdIljW0GQR1XS
SNU-387 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP6NVhKSzVyPUCuPVAzPjRizszN M2m5d3NCVkeHUh?=
SK-MEL-24 M3jYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3HZW9pUUN3ME2wMlkyOzR2IN88US=> M2LOe3NCVkeHUh?=
MDA-MB-468 NH\hT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX1ZlJKSzVyPUCuPVE4OyEQvF2= M4DB[3NCVkeHUh?=
NCI-H1694 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH1TWM2OD1yLkmxPFc3KM7:TR?= MULTRW5ITVJ?
CCF-STTG1 NYWyS5VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPrWYNKSzVyPUCuPVI3OzdizszN M4j4W3NCVkeHUh?=
K052 M2rUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDDT3VOUUN3ME2wMlk1ODR5IN88US=> MV3TRW5ITVJ?
NCI-H446 NYXDXmVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jvZ2lEPTB;MD65OVAyKM7:TR?= MXXTRW5ITVJ?
MFE-280 MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqxTWM2OD1yLkm2NlkyKM7:TR?= M1HlWXNCVkeHUh?=
KU812 MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzFd4RKSzVyPUCuPVk{QDlizszN MXvTRW5ITVJ?
MDA-MB-361 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\G[Wd4UUN3ME2wMlk6Pzd5IN88US=> NVS1b5MxW0GQR1XS
Raji MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwMEKyOlch|ryP MVLTRW5ITVJ?
TE-6 M3ToTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPCTWM2OD1zLkCzOVY3KM7:TR?= NXHCR|BSW0GQR1XS
CAL-148 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFwMES0OFMh|ryP NYjxUG5bW0GQR1XS
NCI-H1963 NXSzXZR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD0VWJ4UUN3ME2xMlA1PTV|IN88US=> NUe1cGlOW0GQR1XS
SK-N-AS M1m2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi2WGlFUUN3ME2xMlA1Pjh3IN88US=> NV32VHFMW0GQR1XS
RERF-LC-MS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zIb2lEPTB;MT6wOlM1QSEQvF2= NXnPbIdQW0GQR1XS
BEN M37zR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[0WIZKSzVyPUGuNFcyOzdizszN NH35e2tUSU6JRWK=
CAS-1 NHLic5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTFwMEmxNlMh|ryP MV7TRW5ITVJ?
SW780 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFwMEmxPFEh|ryP NFrt[oRUSU6JRWK=
LU-65 NI\qUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXFO5hKSzVyPUGuNFk1OSEQvF2= MljSV2FPT0WU
D-283MED MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDDfZRQUUN3ME2xMlEzOjd{IN88US=> NXexdJptW0GQR1XS
HCC2157 NIHzUY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzkTWM2OD1zLkGzOlQzKM7:TR?= NV7hfJNFW0GQR1XS
RCC10RGB M3TROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwMUSwNFYh|ryP NEHx[lhUSU6JRWK=
PLC-PRF-5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwMUWyNlkh|ryP Ml[wV2FPT0WU
H4 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjOS5VPUUN3ME2xMlE2PDN7IN88US=> M1LrZnNCVkeHUh?=
TUR NWDrTJJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwMUW3OVIh|ryP MWHTRW5ITVJ?
NCI-H2141 NFn1THZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPLRpJYUUN3ME2xMlE5QTR4IN88US=> M1nGPHNCVkeHUh?=
PFSK-1 NEDjdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL4S2ZUUUN3ME2xMlIxPTN{IN88US=> Mln4V2FPT0WU
SK-MEL-28 NGrBRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfLTWM2OD1zLkKzNlIyKM7:TR?= MYPTRW5ITVJ?
SCC-9 NHnlT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTFwMkO2OlUh|ryP NVjsOZdpW0GQR1XS
T47D MnHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq2SGZKSzVyPUGuNlM3QTZizszN NUDweZV2W0GQR1XS
TCCSUP NYHQ[nVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qzXmlEPTB;MT6yOVAzQSEQvF2= NGG4TWRUSU6JRWK=
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NCI-H187 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjlUVNKSzVyPUWuPVI6QDlizszN MWLTRW5ITVJ?
LU-165 M4fROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O5dmlEPTB;NT65PVAxOiEQvF2= MVvTRW5ITVJ?
YAPC NID2WHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rhXGlEPTB;NT65PVA3QCEQvF2= MkHKV2FPT0WU
LU-139 NF3aSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnJTWM2OD14LkC4N|Y5KM7:TR?= M1jrenNCVkeHUh?=
D-502MG M{Htcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf5TWM2OD14LkOyNFQ4KM7:TR?= NGrsPVVUSU6JRWK=
IST-SL1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\VTWM2OD14LkWzPVQ5KM7:TR?= NUDkdYwxW0GQR1XS
DG-75 M{jqOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD3TGFbUUN3ME22Mlg5Pzh4IN88US=> M2jIWnNCVkeHUh?=
NCI-H1155 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK3[JA4UUN3ME22Mlk2PThzIN88US=> Mn3UV2FPT0WU
EFE-184 M2nKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnznTWM2OD15LkOxOlk2KM7:TR?= NUOxb5p4W0GQR1XS
AsPC-1 NYTkcXhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TKVmlEPTB;Nz60PFgxPyEQvF2= NHjWSmNUSU6JRWK=
SW948 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfK[lRKSzVyPUeuOVg{QTVizszN MUXTRW5ITVJ?
NCI-H524 NGfMNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTXNFN{UUN3ME25MlU5PjJ6IN88US=> MV7TRW5ITVJ?
KOSC-2 NHnjellIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXkeZBPUUN3ME25MlYzQDN2IN88US=> MVzTRW5ITVJ?
T-24 NGHZb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm0R3BbUUN3ME25Mlk1PDF3IN88US=> MnTXV2FPT0WU
NCI-H748 MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrZV45KSzVyPUGwMlY{QTdizszN NFzrVopUSU6JRWK=
NCI-H23 NV:wbFJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFyLk[0OFIh|ryP MYnTRW5ITVJ?
UACC-812 M4X6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zL[GlEPTB;MUGuO|E4KM7:TR?= MVjTRW5ITVJ?
SCLC-21H M3m3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LEUGlEPTB;MUKuNVU2OSEQvF2= M1r1O3NCVkeHUh?=
NCI-SNU-16 NULzb5FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW4XWtvUUN3ME2xN{4yOjV6IN88US=> NHPoTllUSU6JRWK=
HD-MY-Z NUCxeYhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TMSGlEPTB;MUSuOlM3OyEQvF2= MYLTRW5ITVJ?
SK-N-FI NITDWoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofsTWM2OD1zND64PVEzKM7:TR?= M3KzSXNCVkeHUh?=
LB647-SCLC Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn0c5pKSzVyPUG1MlcyQTVizszN M3rvO3NCVkeHUh?=
NCI-H345 M2XYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF5LkO0N{DPxE1? NIG3fodUSU6JRWK=
NCI-H1563 NXHubotmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL1eYZSUUN3ME2xPE44PjBzIN88US=> NW\QUo5jW0GQR1XS
RL M2G4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJzLkK2OVYh|ryP NHTzOG5USU6JRWK=
KY821 M4\yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fHbWlEPTB;MkKuNFU2OyEQvF2= NITafm5USU6JRWK=
JVM-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ3LkC0NVMh|ryP Ml\kV2FPT0WU
NCI-H1793 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJ6LkW0PVkh|ryP MXPTRW5ITVJ?
LU-134-A MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ixXWlEPTB;M{CuNlA{PyEQvF2= MkC2V2FPT0WU
NCI-H1395 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13XPGlEPTB;M{KuNlQ{OSEQvF2= Mn\vV2FPT0WU
NCI-H1993 M2rVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvIRmNKSzVyPUOyMlgzOThizszN MYDTRW5ITVJ?
P31-FUJ M3qwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrheHVKSzVyPUOzMlQ5QTlizszN MXjTRW5ITVJ?
LS-513 MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHflWHBKSzVyPUO1Mlg5PzlizszN MXfTRW5ITVJ?
SK-MEL-1 NIHvNGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Cwc2lEPTB;NECuN|Q6QSEQvF2= NH73dpBUSU6JRWK=
SW684 NGW1fXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[5O5VKSzVyPUSzMlk3PjFizszN NWHLOoNbW0GQR1XS
COR-L88 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXR[WtPUUN3ME20OE4xPjZ3IN88US=> MV3TRW5ITVJ?
NCI-H889 NU\0enE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTVTWM2OD12NT6wNFg4KM7:TR?= M4H1d3NCVkeHUh?=
TALL-1 NHmzfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n4SWlEPTB;NE[uNVE6QSEQvF2= MWnTRW5ITVJ?
KARPAS-299 M1TTZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjmTWM2OD12Nz6xPVk{KM7:TR?= NHW1VGdUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Cyclin D1 / p27 Kip1 ; 

PubMed: 28382170     


Western blotting showed that Obatoclax impacted cell cycle distribution through lowering cyclin D1 in K1 cells but in BCPAP cells, it impacted expression of p27 Kip1 rather than cyclin D1.

p-Cyclin D1 ; 

PubMed: 28035994     


Cell line-dependent effect of obatoclax on cyclin D1 T286 phosphorylation. HCT116, HT-29, and LoVo cells were subject to 24 h-treatment with obatoclax (200 nM), followed by immunoblotting to evaluate the levels of threonine 286 (T286)-phosphorylated cyclin D1 (p-Cyclin D1) at indicated time points. α-Tubulin levels served as equal loading control;

p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38; 

PubMed: 28035994     


Obatoclax inhibits GSK3β but activates p38 (MAPK), while barely affecting ERK1/2 activity in HT-29 cells. HT-29 cells were exposed to 200 nM of obatoclax for 24 h. The status of activation of GSK3β, ERK1/2, and p38(MAPK) at indicated time points was determined by immunoblotting for corresponding phosphorylation. Specifically, serine 9-phosphorylation of GSK3β (p-GSK3β) reveals inhibition of GSK3β activity, whereas dual phosphorylation at threonine 202/tyrosine 204 of ERK1/2 (p-ERK1/2) and threonine 180/tyrosine 182 of p38 MAPK (p-p38) indicate activation of ERK1/2 and p38(MAPK), respectively. α-Tubulin levels served as equal loading control;

28382170 28035994
Growth inhibition assay
Cell proliferation ; 

PubMed: 28035994     


Obatoclax inhibits colorectal cancer cell proliferation. Human colorectal carcinoma cell lines HCT116, HT-29, and LoVo cells were treated with obatoclax (0, 50, 100, 200 nM) for 24, 48, and 72 h. The numbers of cells at each time point were counted using a Neubauer chamber. Data were presented as the percentage relative to the drug-untreated control.

Cell viability; 

PubMed: 21368880     


H727 NSCLC cells are resistant to obatoclax. H727 and H1975 NSCLC cells were treated with obatoclax at the indicated doses for 48 (left) or 72 h (right), and the viability of cells determined by ViaLight assay. The EC50 values of cells at 48 h were; H1975 267 nM; H727 3.2 μM. The EC50 values of cells at 72 h were; H1975 66 nM; H727 621 nM. Data are expressed as mean±S.D. 

28035994 21368880
In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
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Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
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  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00438178 Completed Drug: Obatoclax mesylate (GX15-070MS) Hematological Malignancies Gemin X|Teva Pharmaceutical Industries October 2005 Phase 1
NCT00600964 Completed Drug: GX15-070MS Chronic Lymphocytic Leukemia Gemin X|Teva Pharmaceutical Industries September 2004 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID