Olaparib (AZD2281)

Catalog No.S1060 Synonyms: Ku-0059436

For research use only.

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.

Olaparib (AZD2281) Chemical Structure

CAS No. 763113-22-0

Selleck's Olaparib (AZD2281) has been cited by 890 publications

Purity & Quality Control

Choose Selective PARP Inhibitors

Other PARP Products

Biological Activity

Description Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.
Features A potent PARP inhibitor (currently in late stage clinical trials).
Targets
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
1 nM 5 nM
In vitro

Olaparib would act against BRCA1 or BRCA2 mutations. Olaparib is not sensitive to tankyrase-1 (IC50 >1 μM). Olaparib could ablate the PARP-1 activity at concentrations of 30-100 nM in SW620 cells. Olaparib is hypersensitive to BRCA1-deficient cell lines (MDA-MB-463 and HCC1937), compared with BRCA1- and BRCA2-proficient cell lines (Hs578T, MDA-MB-231, and T47D). [1] Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Hep3B MkDDSpVv[3Srb36gRZN{[Xl? NHHaVJg1OCEQvF2= MnrINlQhcA>? NX;5NodSTE2VTx?= MUfJcoR2[2W|IGLPV{Bxem:mdXP0bY9vKHerdHigSGhOTVF? M1S4bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEeyO|UzLz5{NUC3Nlc2OjxxYU6=
Huh7 NGDDd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nLeVQxKM7:TR?= M4\ae|czKGh? MkfUSG1UVw>? NF3SR5RUgW6ncnfpd5Rq[2GubImgbY5pcWKrdIOgZ4VtdCCpcn;3eIghf2m2aDDETG1GWQ>? NVnUbmZXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwO|I4PTJpPkK1NFczPzV{PD;hQi=>
Hep3B MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XTUVQxKM7:TR?= NYjrXohrPzJiaB?= M1;1bGROW09? M1H6[3N6dmW{Z3nzeIlk[WyueTDpcohq[mm2czDj[YxtKGe{b4f0bEB4cXSqIFTIUWVS M2HGSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MEeyO|UzLz5{NUC3Nlc2OjxxYU6=
TE-6 MonUSpVv[3Srb36gRZN{[Xl? M3XtflUh|ryP MXKyOEBp MX;EUXNQ MYjJcoNz\WG|ZYOgbY4h\G:3YnzlJJN1emGwZDDidoVic3NiKFTTRpMq MnTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MUmxOlQoRjJ2MkG5NVY1RC:jPh?=
TE-6 NXvCdINCTnWwY4Tpc44hSXO|YYm= NIXNS3E2KM7:TR?= MXyxNkBp NUjBb|VJTE2VTx?= MmqyTY5lfWOnczDHNk9OKGG{cnXzeC=> NUDIfotbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVkyPjRpPkK0NlE6OTZ2PD;hQi=>
HT29 NH\OfohHfW6ldHnvckBCe3OjeR?= M2\oXFExKG6P NX\kdXJ5OTJiaB?= M4Xt[GROW09? M3LnSGlv[3KnYYPld{BFVkFiZH;1ZoxmNXO2cnHu[EBjemWja4OgbY5lfWOnZDDifUBUVi1|OB?= M2TLdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUe3PVQyLz5{NEW3O|k1OTxxYU6=
HCT116 Mo\sSpVv[3Srb36gRZN{[Xl? NGXkepoyOCCwTR?= NU[4XZh7OTJiaB?= M3\NSmROW09? M2K5Nmlv[3KnYYPld{BFVkFiZH;1ZoxmNXO2cnHu[EBjemWja4OgbY5lfWOnZDDifUBUVi1|OB?= NVTteVJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1O|c6PDFpPkK0OVc4QTRzPD;hQi=>
RKO NXSzNIdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1W2O|ExOCEQvF2= M{jkeFQ5KGh? MoLiSG1UVw>? MXXQc5RmdnSrYYTld{BUVi1|ODDjfZRwfG:6aXPpeJk> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV5N{m0NUc,OjR3N{e5OFE9N2F-
C-1 NUf1S|lLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rkN|ExOCEQvF2= NV\Jc48zPDhiaB?= M4DtbWROW09? NVHBRYwxWG:2ZX70bYF1\XNiU16tN|gh[3m2b4TvfIlkcXS7 NYns[|AxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1O|c6PDFpPkK0OVc4QTRzPD;hQi=>
SW48 NWDRb5kzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDETYFnOTByIN88US=> MYi0PEBp MUXEUXNQ M{LxXXBwfGWwdHnheIV{KFOQLUO4JIN6fG:2b4jpZ4l1gQ>? NFrBPJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW3O|k1OSd-MkS1O|c6PDF:L3G+
LoVo M4fYPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HSe|ExOCEQvF2= MX20PEBp M1L4ZmROW09? NFjCbXVRd3SnboTpZZRmeyCVTj2zPEBkgXSxdH;4bYNqfHl? NYPuUWx1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1O|c6PDFpPkK0OVc4QTRzPD;hQi=>
HT29 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:xNFAh|ryP M2\xN|Q5KGh? NHPOT49FVVOR M1\pN3BwfGWwdHnheIV{KFOQLUO4JIN6fG:2b4jpZ4l1gQ>? M1HJN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUe3PVQyLz5{NEW3O|k1OTxxYU6=
SW1116 MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjRN5dGOTByIN88US=> M4i4PFQ5KGh? M2jWemROW09? MVPQc5RmdnSrYYTld{BUVi1|ODDjfZRwfG:6aXPpeJk> Ml\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3N{e5OFEoRjJ2NUe3PVQyRC:jPh?=
HCT116 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK3bXYyODBizszN MlLrOFghcA>? NVLQSVlMTE2VTx?= M2L3TXBwfGWwdHnheIV{KFOQLUO4JIN6fG:2b4jpZ4l1gQ>? NH\rUpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW3O|k1OSd-MkS1O|c6PDF:L3G+
RKO Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxNFAh|ryP MnPvOFghcA>? NVz1[HBHTE2VTx?= Mk\zTWM2OD13Lkmg{txO MoLZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3N{e5OFEoRjJ2NUe3PVQyRC:jPh?=
C-1 NV3RTVZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHYfIVXOTByIN88US=> MX20PEBp NFTVfHZFVVOR NGTlOo1KSzVyPUeuOkDPxE1? NVT3cZBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1O|c6PDFpPkK0OVc4QTRzPD;hQi=>
SW48 NXjiNFhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\jcFFWOTByIN88US=> M1\QZlQ5KGh? M1jwUmROW09? M4fpPWlEPTB;OT61JO69VQ>? M3yy[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUe3PVQyLz5{NEW3O|k1OTxxYU6=
HCT-15 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqxNFAh|ryP MWq0PEBp NHfVTZNFVVOR NVzqbIh3UUN3ME2xNEDPxE1? NGrUXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEW3O|k1OSd-MkS1O|c6PDF:L3G+
LoVo MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7zNoREOTByIN88US=> NHXoPW81QCCq MlTJSG1UVw>? NY\Zc2c1UUN3ME2xN{41KM7:TR?= NV7rZVFvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1O|c6PDFpPkK0OVc4QTRzPD;hQi=>
HT29 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7DNnJVOTByIN88US=> NVfHZYJbPDhiaB?= NVTONnZrTE2VTx?= M{D3[WlEPTB;MUSuO{DPxE1? MkTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3N{e5OFEoRjJ2NUe3PVQyRC:jPh?=
SW1116 NGHKcHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDtcFVpOTByIN88US=> MWi0PEBp NIf5VmZFVVOR NELk[Y1KSzVyPUGwNEDPxE1? MmTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3N{e5OFEoRjJ2NUe3PVQyRC:jPh?=
HCT116 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV2xNFAh|ryP M2C0clQ5KGh? NEOz[mtFVVOR NFXReGFKSzVyPUKuOUDPxE1? M3jhS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUe3PVQyLz5{NEW3O|k1OTxxYU6=
T47D MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYO1JIRigQ>? Mn7vTWM2OD17Lk[g{txO NHXYb2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e2NFQ6Pid-MkO3OlA1QTZ:L3G+
MCF7 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\QcVZ7PSCmYYm= NUT4Zm9vUUN3ME21Mlgh|ryP MkjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5NkC0PVYoRjJ|N{[wOFk3RC:jPh?=
CAMA1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPMO4FCPSCmYYm= M1y2bmlEPTB;MUWuPEDPxE1? NEXRe4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e2NFQ6Pid-MkO3OlA1QTZ:L3G+
SUM159 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37le|Uh\GG7 M4HhW2lEPTB;ND6yJO69VQ>? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd4MES5Okc,OjN5NkC0PVY9N2F-
SKBR3 M4rCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nRXlUh\GG7 NWXocWhHUUN3ME2xNU4yKM7:TR?= MlHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5NkC0PVYoRjJ|N{[wOFk3RC:jPh?=
JIMT1 M2XZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWq1JIRigQ>? M33Lb2lEPTB;Nz63JO69VQ>? NWn1NZlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3OlA1QTZpPkKzO|YxPDl4PD;hQi=>
BT474 M3LVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHI[HprPSCmYYm= NVi4RWhCUUN3ME2xPU45KM7:TR?= NIjwRo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e2NFQ6Pid-MkO3OlA1QTZ:L3G+
Hs578t(si) MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XtNVUh\GG7 M2\wUGlEPTB;Nz61JO69VQ>? MmrrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5NkC0PVYoRjJ|N{[wOFk3RC:jPh?=
Hs578t NVH5PXVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\EWmJiPSCmYYm= MmDhTWM2OD13Lk[g{txO NE[1[Vk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e2NFQ6Pid-MkO3OlA1QTZ:L3G+
HCC1937 MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[1JIRigQ>? NET1XmhKSzVyPUGyMlYh|ryP M2nUTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{[wOFk3Lz5{M{e2NFQ6PjxxYU6=
HCC1143 NF\DUXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzPeHE2PSCmYYm= MkLQTWM2OD1zMT6xJO69VQ>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd4MES5Okc,OjN5NkC0PVY9N2F-
BT20 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\wW|Uh\GG7 MVjJR|UxRTdwNzFOwG0> NWntXVBQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3OlA1QTZpPkKzO|YxPDl4PD;hQi=>
MDA-MB-468 MmK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDmeYRPPSCmYYm= M1v1U2lEPTB;NT6wJO69VQ>? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd4MES5Okc,OjN5NkC0PVY9N2F-
MDA-MB-231 MnL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\BdGM2KGSjeR?= NXLGUWJmUUN3ME22Mlkh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd4MES5Okc,OjN5NkC0PVY9N2F-
PC-9PTEN− MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqyNEDPxE1? MofLNVQ1KGh? NHXN[pVKSzVyPU[uOVIh|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ|OUiwPUc,OjN{M{m4NFk9N2F-
PC-9 M3f5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zuUlIxKM7:TR?= NIDWcVgyPDRiaB?= MoLyTWM2OD13Lki4JO69VQ>? NF;XUnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KzPVgxQSd-MkOyN|k5ODl:L3G+
H1650PTEN+ NF3pTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXmyNEDPxE1? MXKxOFQhcA>? NVPre5I2UUN3ME21NE45OyEQvF2= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ|OUiwPUc,OjN{M{m4NFk9N2F-
H1650 M1XxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\mb|IzOCEQvF2= MVyxOFQhcA>? NYDBSI9UUUN3ME2xOU41PyEQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ|OUiwPUc,OjN{M{m4NFk9N2F-
Mouse ATM−/− ES Cells Mk\rR5l1d3SxeHnjJGF{e2G7 NEDF[2ozNjVizszN MmTUNlAhcA>? NXewVJJLW2mpbnnmbYNidnSueTDpcohq[mm2czDj[YxtKHO3co\peoFt MnfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|NUW0PFkoRjJ|M{W1OFg6RC:jPh?=
Mouse H2AX−/− ES Cells NVrjPJdLS3m2b4TvfIlkKEG|c3H5 NHTybXczNjVizszN NIHubmUzOCCq MWPTbYdvcW[rY3HueIx6KGmwaHnibZR{KGOnbHygd5Vzfmm4YXy= M{myS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{W1OFg6Lz5{M{O1OVQ5QTxxYU6=
VCaP NV74NVdPUW64YYPpeoUhSXO|YYm= MVKyOUDPxE1? NF;aPHI1QCCq M1nNVGROW09? M2PPdHNq\26rZnnjZY51dHlicnXkeYNmeyCHUlet[JJqfmWwIHPlcIwhcW64YYPpc44> NXHhe4hkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1O|U5PjVpPkKxOVc2QDZ3PD;hQi=>
RWPE NWPaZVdsUW64YYPpeoUhSXO|YYm= M{LzfFI2KM7:TR?= M3vTblQ5KGh? MkLWSG1UVw>? NXjXWVNMW2mpbnnmbYNidnSueTDy[YR2[2W|IFXSS{1lemm4ZX6gZ4VtdCCrbo\hd4lwdg>? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV5NUi2OUc,OjF3N{W4OlU9N2F-
Z138 MojQR5l1d3SxeHnjJGF{e2G7 M3uwWFUh|ryP NI\3U5E6PiCq Mm\3SG1UVw>? M3j0ZnNtcWeqdHz5JIlvcGmkaYTzJINmdGxic4Xyeol3[Wx? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF{NES1PUc,OjBzMkS0OVk9N2F-
JVM-2 MV\DfZRwfG:6aXOgRZN{[Xl? MXe1JO69VQ>? MofHPVYhcA>? NVHFPFZTTE2VTx?= NFLSUIdUdGmpaITsfUBqdmirYnn0d{Bk\WyuIIP1dpZqfmGu NFj1U2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGyOFQ2QSd-MkCxNlQ1PTl:L3G+
HBL-2 NVrZO4Q{S3m2b4TvfIlkKEG|c3H5 M{nCUFUh|ryP NV\0bXdzQTZiaB?= NXnZepZNTE2VTx?= MUjTcIlocHSueTDpcohq[mm2czDj[YxtKHO3co\peoFt Mlm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMkS0OVkoRjJyMUK0OFU6RC:jPh?=
UPN2 NV71c4toS3m2b4TvfIlkKEG|c3H5 NHPtNlI2KM7:TR?= MkTNPVYhcA>? M1e2SWROW09? NEHPS3FUdGmpaITsfUBqdmirYnn0d{Bk\WyuIIP1dpZqfmGu Mn3KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzMkS0OVkoRjJyMUK0OFU6RC:jPh?=
BT MVvDfZRwfG:6aXOgRZN{[Xl? NYrp[ohxPSEQvF2= M3jNPFk3KGh? NXXW[2NwTE2VTx?= MYXTcIlocHSueTDpcohq[mm2czDj[YxtKHO3co\peoFt MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF{NES1PUc,OjBzMkS0OVk9N2F-
Granta-519 MmPUR5l1d3SxeHnjJGF{e2G7 MY[1JO69VQ>? MkLSPVYhcA>? NH7H[GZFVVOR M3\iUnNtcWeqdHz5JIlvcGmkaYTzJINmdGxic4Xyeol3[Wx? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF{NES1PUc,OjBzMkS0OVk9N2F-
L3 MVHDfZRwfG:6aXOgRZN{[Xl? NXTqPFl3PSEQvF2= NH3WN|Y6PiCq NGXabIFFVVOR M4T5N3Nq\26rZnnjZY51dHliaX7obYJqfHNiY3XscEB{fXK4aY\hcC=> M3\xSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUK0OFU6Lz5{MEGyOFQ2QTxxYU6=
T98G NX\DSW51TnWwY4Tpc44hSXO|YYm= Mn;WNUDPxE1? NEn5TVYzPCCq MlXRSY5p[W6lZYOgdoFlcWG2aX;uMYlv\HWlZXSgV{1xcGG|ZTDhdpJme3R? NWj3UWFDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5OVQ4OTJpPkG4PVU1PzF{PD;hQi=>
HeLa Ml7uSpVv[3Srb36gRZN{[Xl? NFTsc5kyKM7:TR?= MXiyOEBp NVrJdWVRTW6qYX7j[ZMhemGmaXH0bY9vNWmwZIXj[YQhWy2yaHHz[UBienKnc4S= M{nTNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUW0O|EzLz5zOEm1OFcyOjxxYU6=
HeLa MmLRSpVv[3Srb36gRZN{[Xl? MVe1NFAhdk1? M3fzSlQhcA>? NWrXfWM3S2G3c3XzJIEhdW:mZYP0JIRmdGG7IHnuJJJmcm:rbnnu[{Bw\iC{YXTpZZRqd25vaX7keYNm\CCGTlGgZpJm[Wu| M2DBclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUW0O|EzLz5zOEm1OFcyOjxxYU6=
UVW NFTjO2dEgXSxdH;4bYMhSXO|YYm= NVTvOo5sPTByIH7N NGi4NVIzPCCq MUXJcoNz\WG|ZYOgdoFlcWG2aX;uJJNmdnOrdHn2bZR6 NUjNcGFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5OVQ4OTJpPkG4PVU1PzF{PD;hQi=>
U87-MG NGPpOHhEgXSxdH;4bYMhSXO|YYm= NFHu[|UyKM7:TR?= MmLUNlQhcA>? MlTYTY5kemWjc3XzJJJi\GmjdHnvckB{\W6|aYTpeol1gQ>? MoTVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7NUS3NVIoRjF6OUW0O|EzRC:jPh?=
T98G M3qxbmN6fG:2b4jpZ{BCe3OjeR?= MXuxJO69VQ>? NYXMeodXOjRiaB?= M17RUGlv[3KnYYPld{Bz[WSrYYTpc44he2Wwc3n0bZZqfHl? NYK3d5N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi5OVQ4OTJpPkG4PVU1PzF{PD;hQi=>
U373-MG NVjnNFB5S3m2b4TvfIlkKEG|c3H5 NWLqdHBLOSEQvF2= NFK1Vo8zPCCq M4XjcWlv[3KnYYPld{Bz[WSrYYTpc44he2Wwc3n0bZZqfHl? M{[3XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUW0O|EzLz5zOEm1OFcyOjxxYU6=
KB2P1.21 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHp[3Y{PCCm M2LBO2lEPTB;OEmwO{BvVQ>? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV3OU[xN{c,OTh3NUm2NVM9N2F-
KB2P3.4 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\zXog1KGR? MmPCTWM2OD1zMkSgUS=> MkHvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3NUm2NVMoRjF6NUW5OlE{RC:jPh?=
KP7.7 NFXHbIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjXW3ByPCCm NU\yV4J7UUN3ME21O{BvVQ>? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV3OU[xN{c,OTh3NUm2NVM9N2F-
KP6.3 M3\tZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzHNms1KGR? Mmn1TWM2OD1zMD60Nlgh|ryP NFSwcIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEW1PVYyOyd-MUi1OVk3OTN:L3G+
KP3.33 M{e0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3RXYdnPCCm NE\3OohKSzVyPUWuO|A2KCEQvF2= MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV3OU[xN{c,OTh3NUm2NVM9N2F-
Huh7 NX\EXmd{TnWwY4Tpc44hSXO|YYm= NIDYXXM1OCEQvF2= MYOyOEBp MkC5SG1UVw>? MYXJcoR2[2W|IGLPV{Bxem:mdXP0bY9vKHerdHigSGhOTVF? NWm4T|JMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwO|I4PTJpPkK1NFczPzV{PD;hQi=>
Hep3B Mn;PSpVv[3Srb36gRZN{[Xl? NXn4Tph5PDBizszN NVq0UWgyOjRiaB?= MULEUXNQ MVfJcoR2[2W|IHPlcIwh[XW2b4DoZYd6KHerdHigSGhOTVF? MmjmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVyN{K3OVIoRjJ3MEeyO|UzRC:jPh?=
Huh7 MnL0SpVv[3Srb36gRZN{[Xl? NHLFdoI1OCEQvF2= MV[yOEBp NVfINIFMTE2VTx?= MV\JcoR2[2W|IHPlcIwh[XW2b4DoZYd6KHerdHigSGhOTVF? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTB5Mke1Nkc,OjVyN{K3OVI9N2F-
SGC-7901 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGzNGFtOzBizszN M{TDflQ5KGh? MmT4SG1UVw>? NHPvO5NDdG:lazDvfIFtcXCuYYTpck1qdmS3Y3XkJINmdGxiZHXheIg> Mkf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NkewO|YoRjJ3N{[3NFc3RC:jPh?=
Sf9 MVHzeJJmeHSjdnnkbY4ucG:{c3XyZYRqe2hicHXyc5hq\GG|ZT3iZZNm\CCudX3pcoV{[2WwY3WgZZN{[Xl? M2DU[2lEPTB;MD6wNFEh|ryP NFPmS3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW0OlIyQSd-Mk[1OFYzOTl:L3G+
T98G MlP6bY1ufW6xZnz1c5Jme2OnbnPlJIF{e2G7 MX\JR|UxRTBwMECxOkDPxE1? NXvaS2U1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0Olk{ODFpPkK2OFY6OzBzPD;hQi=>
G7 NIX0XFlqdW23bn;mcJVwemW|Y3XuZ4Uh[XO|YYm= MkHoTWM2OD1yLkCwNVYh|ryP MnLpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ2NkmzNFEoRjJ4NE[5N|AyRC:jPh?=
HeLa MVPmcJVwemW|Y3XuZ4Uh[XO|YYm= NWnOXIF7TUN3ME2wMlAxOjVizszN M2Hyd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{m4N|g{Lz5{NEO5PFM5OzxxYU6=
Sf9 MWrVWk9XcXNic4DlZ5Rzd3Cqb4TvcYV1emmlIHHuZYx6e2m| M{H1[GlEPTB;MD6wNFI5OSEQvF2= M3HPUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkCxOVA6Lz5{OE[wNVUxQTxxYU6=
Sf9 M{m2TpN1emWydHH2bYRqdi2qb4Lz[ZJi\Gm|aDDw[ZJwgGmmYYPlMYJie2WmIHz1cYlv\XOlZX7j[UBie3OjeR?= M3LvW2lEPTB;MD6wNFMh|ryP MkjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NE[yNVkoRjJ4NUS2NlE6RC:jPh?=
LoVo NGHiR4VKdmirYnn0bY9vKG:oIGDBVnA> NYTJRpg4TUN3ME2wMlAxOzV5IN88US=> NULMem17RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI4OTdpPkK2OlUzPzF5PD;hQi=>
LoVo MoPXTY5pcWKrdHnvckBw\iCSQWLQ MWfFR|UxRTBwMECzOVch|ryP NVuzfo5nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI4OTdpPkK2OlUzPzF5PD;hQi=>
LoVo NW[1enk2UW6qaXLpeIlwdiCxZjDQRXJR MlPISWM2OD1yLkCwN|U4KM7:TR?= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ3MkexO{c,OjZ4NUK3NVc9N2F-
Sf9 M1n5fnVXN1[rczDzdIVkfHKxcHjveI9u\XS{aXOgZY5idHm|aYO= MUHJR|UxRTBwMECzOVkh|ryP MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZyMUWwPUc,Ojh4MEG1NFk9N2F-
SW620 NYTxcVlGTXhidnn2c{BqdmirYnn0bY9vKG:oIGDBVnAy Mlj3TWM2OD1yLkCwOkDPxE1? M1fpOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OECwPFIzLz5zOEiwNFgzOjxxYU6=
OVCAR8 Mkf2Rolv\GmwZzDh[oZqdmm2eTD0c{BRSVKSMR?= NGS4NJlKSzVyPUCuNFA3KM7:TR?= M1rPUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEW2OlI2Lz5{OUi1OlYzPTxxYU6=
MDA-MB-436 MVHDfZRwfG:6aXPpeJkh[XO|YYm= NXXpTphCS0N3ME2wMlAyPjlizszN M{\PS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OEG1OVA5Lz5{NEixOVUxQDxxYU6=
SKOV3 NYT6NGtXUW6qaXLpeIlwdiCxZjDQRXJROS:SQWLQNi=> NY\Pe5U6UUN3ME2wMlAzODlizszN MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR5M{C1N{c,OjN2N{OwOVM9N2F-
SKOV3 M2P1UWlvcGmkaYTpc44hd2ZiUFHSVFEwWEGUUEK= M1;RbGlEPTB;MD6wNlA6KM7:TR?= M1S3c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEezNFU{Lz5{M{S3N|A2OzxxYU6=
SKOV3 Mn22TY5pcWKrdHnvckBw\iCSQWLQNU9RSVKSMh?= MnH1TWM2OD1yLkCyNFkh|ryP MoPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2N{OwOVMoRjJ|NEezNFU{RC:jPh?=
MX1 M1jDOGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2H6XWVEPTB;MD6wNlMzKM7:TR?= MmHKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK3NVcoRjJ4NkWyO|E4RC:jPh?=
MDA-MB-436 MlvwR2NMQCCxcjDTVmIh[XO|YYm= MX\JR|UxRTBwMEO5N{DPxE1? NYmzRXZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PVI6OTZpPkK4OlkzQTF4PD;hQi=>
MDA-MB-436 M{S2fGN6fG:2b4jpZ4l1gSCjc4PhfS=> NI\Jd2hESzVyPUCuNFQ{OiEQvF2= NGPqeZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3N|A2Oyd-MkO0O|MxPTN:L3G+
Jurkat M3rNNG1VWyCjc4PhfUBqdiCycnXz[Y5k\SCxZjCxNFAhfU1ib3[geIVud3qxbH;tbYRm NHTaXW9GSzVyPUCuNFYh|ryP M4HxW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEWwNVk6Lz5{M{i1NFE6QTxxYU6=
UWB1.289 M{HWWYNmdGxvdHn0[ZIh\2yxIHHzd4F6 MVTFR|UxRTBwMjFOwG0> M3P2NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEW2OlI2Lz5{OUi1OlYzPTxxYU6=
VC8 MVzDfZRwfG:6aXPpeJkh[XO|YYm= M4\MTGNEPTB;MD6yNFEh|ryP Ml65QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2N{OwOVMoRjJ|NEezNFU{RC:jPh?=
LoVo Mn7QR4VtdHSrdHXyMWdtdyCjc4PhfS=> NEmwXlFIUTVyPUCuNlM4KM7:TR?= NXjrd5hIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2OVI4OTdpPkK2OlUzPzF5PD;hQi=>
Capan1 MXTDfZRwfG:6aXPpeJkh[XO|YYm= NVqxUXA{TUN3ME2wMlI2QSEQvF2= M4exfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkWyO|E4Lz5{Nk[1NlcyPzxxYU6=
Capan1 NILyXpBES0t6IH;yJHNTSiCjc4PhfS=> NHvGd4JKSzVyPUCuN|k6OyEQvF2= NWDRSnF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PVI6OTZpPkK4OlkzQTF4PD;hQi=>
VC8 NYfZdYRKS0ONODDhd5NigQ>? M{PiNmNEPTB;MD60OVYh|ryP NUXvO5M6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmzN|UzODVpPkK5N|M2OjB3PD;hQi=>
VC8 MnTER5l1d3SxeHnjbZR6KGG|c3H5 MmfER2M2OD1yLkS2PEDPxE1? NVfBUFZTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS4NVU2ODhpPkK0PFE2PTB6PD;hQi=>
VC8 NIPmW21ES0t6IH;yJHNTSiCjc4PhfS=> NILCUJlKSzVyPUCuOVY2PiEQvF2= Ml;MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4OUK5NVYoRjJ6NkmyPVE3RC:jPh?=
A2780 M1jsS3NTSiCjc4PhfS=> MVvJR|UxRTFizszN MoPtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|OUizPFMoRjJ2M{m4N|g{RC:jPh?=
Sf9 NFf3SoR{fHKncITheollcW5vaH;yd4Vz[WSrc3igdIVzd3irZHHz[U1j[XOnZDDseY1qdmW|Y3XuZ4Uh[XO|YYm= MX3JR|UxRTFwMjFOwG0> NFW5SXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUi1OlYzPSd-Mkm4OVY3OjV:L3G+
Sf9 Mk\rd5Rz\XC2YY\p[IlvNWixcoPldoFlcXOqIIDldo95cWSjc3WtZoF{\WRibIXtbY5me2OnbnPlJIF{e2G7 M3LuTmlEPTB;MT63JO69VQ>? NV[0WW1CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OFYzOTlpPkK2OVQ3OjF7PD;hQi=>
Sf9 Mmfqd5Rz\XC2YY\p[IlvNWixcoPldoFlcXOqIIDldo95cWSjc3WtZoF{\WRibIXtbY5me2OnbnPlJIF{e2G7 MnzhTWM2OD1zLkig{txO NYjZdYl4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4OVY3OjVpPkK5PFU3PjJ3PD;hQi=>
Sf9 Mnn2d5Rz\XC2YY\p[IlvNWixcoPldoFlcXOqIIDldo95cWSjc3WtZoF{\WRibIXtbY5me2OnbnPlJIF{e2G7 NX62XpFVUUN3ME2xMlgh|ryP MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV2NkKxPUc,OjZ3NE[yNVk9N2F-
Sf9 MUHzeJJmeHSjdnnkbY4ucG:{c3XyZYRqe2hicHXyc5hq\GG|ZT3iZZNm\CCudX3pcoV{[2WwY3WgZZN{[Xl? M1jnT2lEPTB;MT65JO69VQ>? NXfyeXJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OFYzOTlpPkK2OVQ3OjF7PD;hQi=>
DLD-1 TOPFlash/EF1a Renilla reporter MnHMV5Rm[WS7LVfsc{BNfWOrZnXyZZNmKGG|c3H5 MmXZTWM2OD1|IN88US=> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV2NkKxPUc,OjZ3NE[yNVk9N2F-
DLD-1 TOPFlash/EF1a Renilla reporter NULUOVJYW3SnYXT5MWdtdyCOdXPp[oVz[XOnIHHzd4F6 NIOwWJFKSzVyPUOg{txO Ml\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NE[yNVkoRjJ4NUS2NlE6RC:jPh?=
UWB1.289 M2KyfYNmdGxvdHn0[ZIh\2yxIHHzd4F6 MnfJSWM2OD12Lkig{txO MnjjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl6NU[2NlUoRjJ7OEW2OlI2RC:jPh?=
HCC1937 NWLG[5N3VVSWIHHzd4F6 MXzJR|UxRTRwOUeg{txO MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd4M{[0PEc,Ojh5NkO2OFg9N2F-
MRC5 M{XsfmN6fG:2b4jpZ4l1gSCjc4PhfS=> M3juUGVEPTB;NT64N{DPxE1? MoPVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK3NVcoRjJ4NkWyO|E4RC:jPh?=
Capan1 M2LKVXNTSiCjc4PhfS=> MmT4TWM2OD14LkOg{txO M2K2WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{m4N|g{Lz5{NEO5PFM5OzxxYU6=
MDA-MB-231 NVXYepBnVVSWIHHzd4F6 NIjsTZJKSzVyPUeuPVIh|ryP NWD0XlJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NFE2ODlpPkK4OlAyPTB7PD;hQi=>
MEF MXHj[YxtNXSrdHXyJIdtdyCjc4PhfS=> MYLFR|UxRThwNTFOwG0> NX\VW2NVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4OVY3OjVpPkK5PFU3PjJ3PD;hQi=>
HCC1937 M2H4OG1VXCCjc4PhfS=> MUDJR|UxRThwNkWg{txO NIn2W|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[wNVUxQSd-Mki2NFE2ODl:L3G+
V79 NFzNPIlEgXSxdH;4bYNqfHliYYPzZZk> NWTVR4RGS0N3ME24Mlk5PSEQvF2= NELmelM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEixOVUxQCd-MkS4NVU2ODh:L3G+
V79 MnuwR5l1d3SxeHnjbZR6KGG|c3H5 MV3DR|UxRTFyIN88US=> NFPnS3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3N|A2Oyd-MkO0O|MxPTN:L3G+
H23 NIrBToNOXFRiYYPzZZk> NGnlfGhKSzVyPUGwJO69VQ>? M3vLeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKxNFM6Lz5{NEWyNVA{QTxxYU6=
V79 NEHMNppES0t6IH;yJHNTSiCjc4PhfS=> MYPJR|UxRTFyIN88US=> M3vIS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkmyPVE3Lz5{OE[5NlkyPjxxYU6=
HCC1937 Ml;ZV3JDKGG|c3H5 M3;2[2lEPTB;MUCuN{DPxE1? NH;YS2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO5PFM5Oyd-MkSzPVg{QDN:L3G+
H460 M1zYOm1VXCCjc4PhfS=> M{LUcmlEPTB;MUKg{txO NEn0[GQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWyNVA{QSd-MkS1NlExOzl:L3G+
MEF NUHEUlhv[2WubD30bZRmeiCpbH:gZZN{[Xl? MmTWSWM2OD1zND62JO69VQ>? NYHCdmtYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm4OVY3OjVpPkK5PFU3PjJ3PD;hQi=>
HCT116 NXfiSlJrVVSWIHHzd4F6 MVPJR|UxRTF3LkGzJO69VQ>? NWXibWQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3OlM3PDhpPkK4O|Y{PjR6PD;hQi=>
Jurkat NVK4N5VEVVSVIHHzd4F6 M{LUU2VEPTB;MU[g{txO NFnTdHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i1NFE6QSd-MkO4OVAyQTl:L3G+
NCI-H1792 MkTRUXRVKGG|c3H5 MVTJR|UxRTF4IN88US=> M2jMSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKxNFM6Lz5{NEWyNVA{QTxxYU6=
NCI-H1693 M1nKPG1VXCCjc4PhfS=> MkO5TWM2OD1zOTFOwG0> MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MUCzPUc,OjR3MkGwN|k9N2F-
NCI-H1703 M3v1SW1VXCCjc4PhfS=> MWfJR|UxRTJyIN88US=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MUCzPUc,OjR3MkGwN|k9N2F-
NCI-H2023 MX\NWHQh[XO|YYm= M4Oz[WlEPTB;MkCg{txO MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MUCzPUc,OjR3MkGwN|k9N2F-
U937 MY\NWHQh[XO|YYm= M3;zNWlEPTB;MkGuPFEh|ryP M4HRblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkCxOVA6Lz5{OE[wNVUxQTxxYU6=
NCI-H1944 NFPXS3hOXFRiYYPzZZk> NEfkSotKSzVyPUK1JO69VQ>? M{W5TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUKxNFM6Lz5{NEWyNVA{QTxxYU6=
H441 Mk\rUXRVKGG|c3H5 MUjJR|UxRTJ6IN88US=> NVrkc49URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlExOzlpPkK0OVIyODN7PD;hQi=>
A549 MUfNWHQh[XO|YYm= NID5UIRKSzVyPUK4JO69VQ>? MkPsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkGwN|koRjJ2NUKxNFM6RC:jPh?=
NCI-H1355 NFnjTnROXFRiYYPzZZk> MXzJR|UxRTN|IN88US=> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MUCzPUc,OjR3MkGwN|k9N2F-
NCI-H2030 M1H6Rm1VXCCjc4PhfS=> MnXETWM2OD1|NDFOwG0> MlPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkGwN|koRjJ2NUKxNFM6RC:jPh?=
MCF7 M2nqd21VXCCjc4PhfS=> MVHJR|UxRTN3LkK0JO69VQ>? Mn;pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MEG1NFkoRjJ6NkCxOVA6RC:jPh?=
NCI-H1568 MkXzUXRVKGG|c3H5 NVT1UFFrUUN3ME2zOkDPxE1? NWP0blVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NlExOzlpPkK0OVIyODN7PD;hQi=>
MCF7 MXTNWHQh[XO|YYm= NWDFdpdsUUN3ME2zOk4zPCEQvF2= NGT4Vo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEe2N|Y1QCd-Mki3OlM3PDh:L3G+
NCI-H2122 MofCUXRVKGG|c3H5 NVvrNmdbUUN3ME2zPEDPxE1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{MUCzPUc,OjR3MkGwN|k9N2F-
MDA-MB-231 M1j6UW1VXCCjc4PhfS=> M1KwT2lEPTB;M{muOVEh|ryP M1rYT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkCxOVA6Lz5{OE[wNVUxQTxxYU6=
A2780/DX MU\TVmIh[XO|YYm= NGq4OHFKSzVyPUSxMlkh|ryP M{jidlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{m4N|g{Lz5{NEO5PFM5OzxxYU6=
MEF Mly5Z4VtdC22aYTldkBodG9iYYPzZZk> Mn\zSWM2OD12OT62JO69VQ>? M3K0ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OEW2OlI2Lz5{OUi1OlYzPTxxYU6=
NCI-H322M NHe3Zo5OXFRiYYPzZZk> MlzTTWM2OD13MDFOwG0> MoniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3MkGwN|koRjJ2NUKxNFM6RC:jPh?=
T47D NH;iXmZOXFRiYYPzZZk> NEDCfpBKSzVyPUWwJO69VQ>? MnnxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MEG1NFkoRjJ6NkCxOVA6RC:jPh?=
HCC827 NHW3WmhOXFRiYYPzZZk> NYHSbo5zUUN3ME21NEDPxE1? NVLGbmlZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NFE2ODlpPkK4OlAyPTB7PD;hQi=>
MCF10A MXzNWHQh[XO|YYm= NGLaWJlKSzVyPUWwJO69VQ>? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZyMUWwPUc,Ojh4MEG1NFk9N2F-
HeLa MVHNWHQh[XO|YYm= MVPJR|UxRTVyIN88US=> Mn7PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MEG1NFkoRjJ6NkCxOVA6RC:jPh?=
K562 M3LTfG1VXCCjc4PhfS=> NIG0O21KSzVyPUWwJO69VQ>? M2L4e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkCxOVA6Lz5{OE[wNVUxQTxxYU6=
Raji MlvHUXRVKGG|c3H5 M4O0[GlEPTB;NUCg{txO M2TCVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkCxOVA6Lz5{OE[wNVUxQTxxYU6=
COLO-800 NIrRTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknSTWM2OD1yLkS0NVY1KM7:TR?= Ml;1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
EoL-1- Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfkOXpKSzVyPUCuOVY1PDZizszN MmXMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
NCI-H209 M4XwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXLXVA6UUN3ME2wMlkyPTV4IN88US=> MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
ES1 NF\SephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LDcWlEPTB;MT6xNVQxQCEQvF2= M33oSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
NKM-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFwMkWzOFch|ryP NET3Zok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
NTERA-S-cl-D1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\sfoI6UUN3ME2xMlM{OzRzIN88US=> Mk[yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
MHH-ES-1 NIDYSY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES3[VVKSzVyPUGuOlIxPjdizszN NFT1Z209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
ES8 M4qySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\EZWlEPTB;MT63NlQyPCEQvF2= NXzFUVU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NCI-H720 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTDTWM2OD1{LkKwOlk6KM7:TR?= MnLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
EW-3 NGDFSJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwMke1N|Qh|ryP Ml:wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
D-566MG NUfUPZUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnKVlNKSzVyPUKuOFQ2PjhizszN NVG1VGlnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
697 M4DueWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLy[lR7UUN3ME2yMlg1OTd|IN88US=> MlP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
ES5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzXcm02UUN3ME2yMlg5OTh7IN88US=> M1SwU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
COLO-684 NF36ZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M124RmlEPTB;Mz61NVY6PiEQvF2= NIHKSmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
ML-2 NXjTcodMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5T2hrUUN3ME2zMlYxODV6IN88US=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
MC-IXC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrrPWdKSzVyPUOuOlM{QTNizszN NWK1XWVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
DB NGGxWmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP4TWM2OD1|Lk[1OFQ5KM7:TR?= MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
HCC2218 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTNwN{OxNFMh|ryP NYrpdWxnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NCI-H510A NGn5foxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTNwOEK3NlQh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
NCI-H526 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTNwOE[5OVgh|ryP NXL1N|ZnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
MV-4-11 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DXWmlEPTB;ND6xN|M{PCEQvF2= NGT0[YI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
PA-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrpOmpKSzVyPUSuNlUzQSEQvF2= NUWzOFg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
EW-22 M1PwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq0OFhKSzVyPUSuN|U5PiEQvF2= MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
KASUMI-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[yTWM2OD12LkSwNVA6KM7:TR?= M4\pUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
LU-139 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrJfGZlUUN3ME20Mlc2QDJ7IN88US=> NULCZo1nRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
SBC-1 NVnSUIhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDwTWM2OD12LkiwPVA5KM7:TR?= NV3sXJd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
H4 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRwOEm0OFMh|ryP MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
EW-11 NWrpVlFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTVwMEiwO|Ih|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
NBsusSR MkHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO0VXU2UUN3ME21MlEzODV3IN88US=> NGTpclE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
RPMI-8226 NWTCR25DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwMUWyOFQh|ryP NVXaPYpGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
DEL MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zaZWlEPTB;NT6yNFAxPiEQvF2= MoXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
ES4 NVrQendCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS4TWM2OD13LkWxN|g6KM7:TR?= NFvobFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
GCT MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4T2R2lEPTB;NT61Olg2PiEQvF2= NIeyOlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
NCI-H1048 NWLFR3BDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTVwOUeyO|Mh|ryP MkjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1 NEnDVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3TOY1KSzVyPU[uNFIzKM7:TR?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
ES7 MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGx[I9KSzVyPU[uNFM2PzdizszN NHGzU2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
SW982 NHLINnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7BVW5KSzVyPU[uNFkyOzdizszN MnzwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
L-363 NVznUHZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTITWM2OD14LkOzPVc1KM7:TR?= NWHkdJRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
HT-1080 NHSwfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj1NXlIUUN3ME22MlQ6Pjh|IN88US=> M2HNOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
HAL-01 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTZwNUGwPUDPxE1? NYPKb4hRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NB14 NXK5[5VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTZwNkSwN|kh|ryP M2LOeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
EW-13 NH\vdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvJTWM2OD14Lke3OFI1KM7:TR?= M13VeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
NY Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPDeFJKSzVyPU[uPVQ3ODVizszN MmLBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
NCI-SNU-5 NFn6fIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHWPVhKSzVyPUeuNVA1OzNizszN NYrZeHRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
MS-1 NXzaNIdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy2SYlKSzVyPUeuNVc1QTRizszN M4PTTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
EW-16 NXLpWZRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\hcJRjUUN3ME23MlMyQDZzIN88US=> NHXJ[5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
LU-65 MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTdwNEi0NVch|ryP MkXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
HGC-27 NXzkUY1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfZTWM2OD15LkeyNVc{KM7:TR?= MljpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
CTB-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTdwN{[xO|Uh|ryP MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
5637 MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnnTm5MUUN3ME23MlkzQDZizszN M2rGbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
U251 NEi4dWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zJWWlEPTB;Nz65OFAyPiEQvF2= NX;vNHhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
HOS MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrTbHZKSzVyPUiuNlMxODdizszN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
DOHH-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\GNZg5UUN3ME24MlI{PThizszN NGjiUWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
EW-1 M1zpVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRThwM{CwPFgh|ryP M3jG[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
BV-173 NVnJd3RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j3NmlEPTB;OD61OVU1KM7:TR?= MlfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
8-MG-BA MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRThwNki5PFgh|ryP MnjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
NB69 NHTM[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X5fmlEPTB;OD63NFkzOSEQvF2= NEX1[Wk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
NCI-H69 NF;YSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLQeppKSzVyPUmuPVA6PjFizszN NEDWeoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
RS4-11 NHv0Xm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTFzLkKyNFgh|ryP MlnNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
ONS-76 M3Xobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2K4OmlEPTB;MUGuNlk1PyEQvF2= M3;3blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
SF539 NHz2S3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFzLkS4PFkh|ryP M1Pub|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
HuO-3N1 NUjiUWlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rIeWlEPTB;MUGuOVc6PiEQvF2= MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
NCI-H1651 M4XKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3DTWM2OD1zMj6zNVE2KM7:TR?= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
KARPAS-45 MmHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PWW2lEPTB;MUKuN|c3KM7:TR?= MkDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NWnVcItvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF{LkS2NFkh|ryP NV70RppCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
LAMA-84 M1G3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPCTWM2OD1zMz6xNFk2KM7:TR?= NHfvTnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
NCI-H1155 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC2TWM2OD1zMz6yPFU3KM7:TR?= MnvNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
CTV-1 NGXES21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF|LkS0OUDPxE1? M1zIZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
QIMR-WIL MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF|Lke4NVQh|ryP MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
H9 MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M16wWWlEPTB;MUOuPFQ4PSEQvF2= M3;kR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
SK-MEL-1 NVrjOXBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr5TWM2OD1zMz65N|Q4KM7:TR?= NWDmVHRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
HD-MY-Z M{\GZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF2LkC2N|ch|ryP MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
TI-73 NYXsOoJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHCRoE2UUN3ME2xOE4zOzV4IN88US=> Mke5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
JVM-3 M4fLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLZTWM2OD1zNT61O|E3KM7:TR?= NHHUXoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
D-247MG M4mzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPNSFhLUUN3ME2xOU42QTNizszN MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
VA-ES-BJ NHfGUXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq5TpRKSzVyPUG1MlYxQTdizszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
NOS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILTSYJKSzVyPUG1MlY2OjJizszN NX;uWYZ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
MOLT-4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\Jd2lEPTB;MU[uO|UzKM7:TR?= M2e0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
Mo-T MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojxTWM2OD1zNz6wPFQ6KM7:TR?= NUDoU4c5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NCI-H1770 NWPFSZBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjmdXpKSzVyPUG3MlE2PDNizszN NFPUeFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
COLO-320-HSR MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjocWFKSzVyPUG3MlE5OjdizszN MknEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
TE-12 MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPYZ4p{UUN3ME2xO{44ODV2IN88US=> NU\LfIZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NCI-H82 NUnvRVVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHexVmNKSzVyPUG3Mlg4OjhizszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
NEC8 NFz4OI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzUc3JuUUN3ME2xPE4yOzF4IN88US=> NG\4UIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
HSC-3 NXu5eFFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DUfWlEPTB;MUiuO|QyPCEQvF2= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
NCI-H1092 MoXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vyTmlEPTB;MUiuO|U6PSEQvF2= NYjDSm5pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NCI-H292 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PTN2lEPTB;MUmuNFQ5QSEQvF2= M1HSc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
L-428 M1\Qb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrv[pVCUUN3ME2xPU42PTlizszN M4mzT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
LU-134-A MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrzfnVKSzVyPUG5MlU4OiEQvF2= NWrMNWFRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
GI-ME-N Ml3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr0RYtKSzVyPUG5MlU4PDdizszN MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
ALL-PO Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP4VYlKSzVyPUG5MlU6PzJizszN MlLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
D-283MED MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\WcGlEPTB;MUmuPVE2KM7:TR?= NH3aNWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
D-423MG NI[zOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjBRoFKSzVyPUG5Mlk6PjdizszN M3XFWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
CAKI-1 M{[yVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vOSGlEPTB;MkCuNlIyQSEQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
ETK-1 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF74N2tKSzVyPUKwMlI3OTVizszN M{H5NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
G-402 NXTL[ld4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJyLkWzN|Qh|ryP Mn3RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
HL-60 MkfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJzLkG2NVMh|ryP MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
A2058 M1uyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XrO2lEPTB;MkGuOFQ4PyEQvF2= M{LKXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
CHP-212 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDyeYRKSzVyPUKxMlkxPTFizszN M1y0UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
KY821 M13kc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljwTWM2OD1{MT65O|Uh|ryP MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
TYK-nu NH3KPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\OVWlEPTB;MkKuNFY2OSEQvF2= NICyVXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
JVM-2 NEm4U4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ{LkK5PFMh|ryP M4nnRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
KU812 M2rTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXuyZ3BTUUN3ME2yNk44OzF{IN88US=> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
MKN28 NUjMSmlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zjVGlEPTB;MkKuPVAyPSEQvF2= M3vPbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
ECC10 MojkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHjTldKSzVyPUKzMlc1OSEQvF2= NXPtR5N1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
BHT-101 M3H6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj6TWM2OD1{ND6wNFA5KM7:TR?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
DU-4475 NWDrNZNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJ2LkOzN|ch|ryP NYHPdo1FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
769-P NYHJb3NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrOdHFKSzVyPUK0Mlg1PjZizszN M1LoOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
HEC-1 MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHxVHZKSzVyPUK1MlQ1PSEQvF2= MnrlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
MOLT-13 NYfl[3RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJ3LkWzN|Eh|ryP M4HRUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
8505C NW[x[XZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DQWWlEPTB;Mk[uOFk4PyEQvF2= NFPlNGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
GB-1 M4XhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TMWGlEPTB;Mk[uO|E4PiEQvF2= M1:yfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
SF126 M3HoZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnj3TWM2OD1{Nj63OlQ5KM7:TR?= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
A4-Fuk MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf3TWM2OD1{Nz6xNlcyKM7:TR?= NV34OHZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
OVCAR-8 MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHLTWM2OD1{Nz6xOVM6KM7:TR?= NGq4RVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
NCI-H1304 NYPmeIJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13CWGlEPTB;MkeuOVQh|ryP MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
GR-ST NFXWW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX3TWM2OD1{OD6wOFch|ryP M4KwVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
G-401 NVu3RmFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\XR4VKSzVyPUK4MlUxQTZizszN NXTPS2VGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
LXF-289 NFLZVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXwSGRKSzVyPUK4MlU3PTFizszN NFXGNXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
DBTRG-05MG MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ6LkmyNFQh|ryP M2PkclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
YKG-1 NWrjWINUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHixOmFKSzVyPUK5Mlg3QCEQvF2= M3j4S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
GAMG M1\teGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\WRnc{UUN3ME2yPU46QTNizszN MkW3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
HCT-116 NVXneGFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfiVW5GUUN3ME2zNE4xPTR6IN88US=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
S-117 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\2SWlEPTB;M{GuNlI2PyEQvF2= NXftc4VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
NCI-H1693 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmC3TWM2OD1|Mz62OVQzKM7:TR?= NV60WZZ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
A427 Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTqTW9KSzVyPUOzMlk6PzZizszN M2fSNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
HT-29 NFLlbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDsfYluUUN3ME2zOE43ODN{IN88US=> NFLVbIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
P12-ICHIKAWA Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTN2Lke0PVEh|ryP MoPiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
CAL-51 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlriTWM2OD1|NT6wO|A6KM7:TR?= NFXDUlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
Ramos-2G6-4C10 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTN3LkK0NlUh|ryP NYqwN5o1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
SCH NV\BOIpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nGPWlEPTB;M{[uOFE4PCEQvF2= M3rTSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
SK-MEL-24 NXvrcXJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHhcFFKSzVyPUO2MlkxPDRizszN MnrCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
SW1573 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHYUmpKSzVyPUO4MlczOTZizszN NVTuWYlmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
BALL-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rBNGlEPTB;M{muNlEzQSEQvF2= M2XlVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
BE-13 NWWzT2F3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESxWo5KSzVyPUO5MlMzQSEQvF2= NHm1WmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
GI-1 NFjQO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN7Lki2OFch|ryP NEjSZog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
GOTO NGPSXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ryS2lEPTB;M{muPVE{QSEQvF2= NYK2R|NvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
A673 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLW[2lKSzVyPUSxMlA{PDNizszN MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1NlE3QDZxJ{7TRW5ITVJ:L3G+
KG-1 MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;6fmlEPTB;NEOuN|k1KM7:TR?= NX:2Rpp2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
GP5d NX;CRZA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHwbVJPUUN3ME20OE4xPjZ4IN88US=> MoXtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
MFM-223 M3WwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3CTWM2OD12ND6xNlI5KM7:TR?= MkHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
OAW-42 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;wS2lEPTB;NESuNlY1OyEQvF2= NFr0d4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
C8166 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGxTWM2OD12NT6wPFIzKM7:TR?= NHrDS5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
LU-99A MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7DUWRiUUN3ME20Ok4yOzJ{IN88US=> M2TpOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
NCI-H23 M1K4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;pU2lEPTB;NE[uNVc5PSEQvF2= NFLjdGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
HO-1-N-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3O3WGlEPTB;NEeuNFk6QCEQvF2= M{C4c|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
A3-KAW NV\L[lZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTR5LkGwNFch|ryP M4\6W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
CGTH-W-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXk[5NKUUN3ME20O{42ODZ7IN88US=> Mn:2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVIyPjh4Lze+V2FPT0WUPD;hQi=>
DJM-1 NGDPZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLITWM2OD12Nz61OFE{KM7:TR?= NVLWdXpjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
A101D M1XnOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHyTWM2OD12Nz62N|U4KM7:TR?= NWXuV4RXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
BB30-HNC NYH0ToV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorkTWM2OD12OD6zNFczKM7:TR?= NWDYNmM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTJzNki2M{c,W0GQR1XSQE9iRg>?
T98G NGnic45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv1TWM2OD12OD60OlM{KM7:TR?= NHPuZpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
NCI-H1573 M1\Ddmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTR7LkS0OlIh|ryP NH;jU3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2OjF4OE[vK|5USU6JRWK8M4E,
MEG-01 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzhTWM2OD12OT63OFEyKM7:TR?= M1LLV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
WM-115 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TrS2lEPTB;NEmuPVIzOiEQvF2= M4f4WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFUzOTZ6Nj:nQnNCVkeHUkyvZV4>
Assay
Methods Test Index PMID
Western Blot DR5/CHOP ; γH2AX/H2AX ; pATM ; 53BP1 ; NF-kB ; pS6/S6 25531448 22933245 27686740 24831086
Immunofluorescence DNA damage ; γH2AX 27686740 28069876
Growth inhibition assay Cell viability 25531448
ELISA IL-8 ; GLP-1 28456021 29392078
In vivo Combining with temozolomide, Olaparib (10 mg/kg, p.o.) significantly suppresses tumor growth in SW620 xenografts. [1] Olaparib shows great response to Brca1-/-;p53-/- mammary tumors (50 mg/kg i.p. per day), while no responses to HR-deficient Ecad-/-;p53-/- mammary tumors. Olaparib even does not show dose-limiting toxicity in tumor-bearing mice. [3] Olaparib has been used to treat with BRCA mutated tumors, such as ovarian, breast and prostate cancers. Moreover, Olaparib shows selectively inhibition to ATM (Ataxia Telangiectasia Mutated)-deficient tumor cells, which indicates to be a potential agent for treating ATM mutant lymphoid tumors. [4]

Protocol (from reference)

Kinase Assay:

[1]

  • FlashPlate assay (96-well screening assay):

    To columns 1 through 10, 1 μL of Olaparib (in DMSO) is added, and 1 μL DMSO only is added to the positive (POS) and negative (NEG) control wells (columns 11 and 12, respectively) of a pretreated FlashPlate. PARP-1 is diluted 1:40 in buffer (buffer B: 10% glycerol (v/v), 25 mM HEPES, 12.5 mM MgCl2,50 mM KCl, 1 mM DTT, 0.01% NP-40 (v/v), pH 7.6) and 40 μL added to all 96 wells (final PARP-1 concentration in the assay is ~1 ng/μL). The plate is sealed and shaken at RT for 15 min. Following this, 10 μL of positive reaction mix (0.2 ng/μL of double-stranded oligonucleotide [M3/M4] DNA per well, 5 μM of NAD+ final assay concentration, and 0.075 μCi 3H-NAD+ per well) is added to the appropriate wells (columns 1-11). The negative reaction mix, lacking the DNA oligonucleotide, is added to column 12 (with the mean negative control value used as the background). The plate is resealed and shaken for a further 60 min at RT to allow the reaction to continue. Then, 50 μL of ice-cold acetic acid (30%) is added to each well to stop the reaction, and the plate is sealed and shaken for a further 60 min at RT. Tritiated signal bound to the FlashPlate is then determined in counts per minute (CPM) using the TopCount plate reader.

Cell Research:

[1]

  • Cell lines: Breast cancer cell lines including SW620 colon, A2780 ovarian, HCC1937, Hs578T, MDA-MB-231, MDA-MB-436, and T47D
  • Concentrations: 1-300 nM
  • Incubation Time: 7-14 days
  • Method:

    The cytotoxicity of Olaparib is measured by clonogenic assay. Olaparib is dissolved in DMSO and diluted by culture media before use. The cells are seeded in six well plates and left to attach overnight. Then Olaparib is added at various concentrations and the cells are incubated for 7-14 days. After that the surviving colonies are counted for calculating the IC50.

Animal Research:

[3]

  • Animal Models: Brca1-/-;p53-/- mammary tumors are generated in K14cre;Brca1F/F;p53F/F mice.
  • Dosages: 50 mg/kg
  • Administration: Administered via i.p. injection at 10 μL/g of body weight

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.

5mg/mL

Chemical Information

Molecular Weight 434.46
Formula

C24H23FN4O3

CAS No. 763113-22-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05128734 Not yet recruiting Drug: Temozolomide|Drug: Olaparib Breast Cancer Triple Negative AHS Cancer Control Alberta December 1 2022 Phase 2
NCT05358639 Not yet recruiting Drug: Olaparib tablet|Drug: Navitoclax High Grade Serous Carcinoma|Triple Negative Breast Cancer|Ovarian Cancer Sunnybrook Health Sciences Centre|Exactis Innovation|Centre hospitalier de l''Université de Montréal (CHUM)|Princess Margaret Hospital Canada June 15 2022 Phase 1
NCT04644289 Recruiting Drug: olaparib|Drug: durvalumab Epithelial Ovarian Cancer AGO Research GmbH May 5 2022 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Frequently Asked Questions

Question 1:
How to prepare the solution of the compound (S1060) for in vivo study?

Answer:
We recommend the following formulation: 4% DMSO+30% PEG300+ 66%H2O. It is a clear solution and can be used for IP injection.

Question 2:
I saw that the solubility of the compound for in vivo on the website had been changed, why the change has been made?

Answer:
For the formulation for in vivo, the compound dissolving in 15% Captisol (former solubility) is a suspension, and it is fine for oral gavage. And now, dissolving in 4% DMSO+30% PEG 300+ddH2O is a clear solution, and is for injection.

Question 3:
How long can the chemical compound be stable in DMEM at 4 °C?

Answer:
The compound is stable in DMEM at 4 degree for one week.

Tags: buy Olaparib (AZD2281) | Olaparib (AZD2281) supplier | purchase Olaparib (AZD2281) | Olaparib (AZD2281) cost | Olaparib (AZD2281) manufacturer | order Olaparib (AZD2281) | Olaparib (AZD2281) distributor