Ivermectin

Catalog No.S1351 Synonyms: MK933

Ivermectin Chemical Structure

Molecular Weight(MW): 875.09

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

Size Price Stock Quantity  
In DMSO USD 350 In stock
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Chloride Channel Inhibitors

Biological Activity

Description Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
Targets
chloride channel [3]
()
In vitro

Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. [1] Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons. [2] Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. [3]

Assay
Methods Test Index PMID
Western blot
YAP1 / CTGF ; 

PubMed: 29296196     


Immunoblotting for total and nuclear expression of YAP1 and CTGF in MKN1 and MKN7 cells. Cells were treated with vehicle (DMSO) or 10 μM ivermectin for 24 h.

29296196
Immunofluorescence
YAP1; 

PubMed: 29296196     


Immunofluorescence staining for YAP1 (red) in MKN1 and MKN7 cells. Scale bars, 20 μm.

29296196
Growth inhibition assay
Cell viability; 

PubMed: 29296196     


Sensitivity of GC cells to ivermectin. Cell viability was measured by MTT assays in GC cells treated with the indicated concentrations of ivermectin for 48 h. 

29296196
In vivo Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration. [4] Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. [5]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (114.27 mM)
Ethanol 28 mg/mL (31.99 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 875.09
Formula

C48H74O14

CAS No. 70288-86-7
Storage powder
in solvent
Synonyms MK933

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03690453 Not yet recruiting Drug: Ivermectin Healthy University of Oxford February 4 2019 Phase 4
NCT03432442 Recruiting Drug: Ivermectin Dengue Hemorrhagic Fever Mahidol University September 4 2018 Phase 2
NCT03717558 Withdrawn Drug: ivermectin T1|Drug: ivermectin T2|Drug: ivermectin T3 Healthy Volunteers Pierre Fabre Dermatology April 30 2018 Phase 1
NCT03527732 Recruiting Drug: Albendazole|Drug: Albendazole and Ivermectin Trichuriasis Jennifer Keiser|Centre Suisse de Recherches Scientifiques (CSRS)|Lao Tropical and Public Health Institute|Public Health Laboratory of Pemba Tanzania|Swiss Tropical & Public Health Institute April 15 2018 Phase 2|Phase 3
NCT02963324 Completed Drug: Ivermectin Malaria University Hospital Basel Switzerland November 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I would like to use S1351 for in vivo studies via IP injection? Do you have some suggestions?

  • Answer:

    You could use the following formula for working solution: 5%DMSO + 40%PEG300 + 5% Tween + ddH2O, reaching a concentration of 12.5mg/ml.

Tags: buy Ivermectin | Ivermectin ic50 | Ivermectin price | Ivermectin cost | Ivermectin solubility dmso | Ivermectin purchase | Ivermectin manufacturer | Ivermectin research buy | Ivermectin order | Ivermectin mouse | Ivermectin chemical structure | Ivermectin mw | Ivermectin molecular weight | Ivermectin datasheet | Ivermectin supplier | Ivermectin in vitro | Ivermectin cell line | Ivermectin concentration | Ivermectin nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID