Catalog No.S1351 Synonyms: MK933

Ivermectin Chemical Structure

Molecular Weight(MW): 875.09

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

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In DMSO USD 350 In stock
USD 97 In stock
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Biological Activity

Description Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
chloride channel [1] chloride channel [3]
In vitro

Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. [1] Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons. [2] Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. [3]

In vivo Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration. [4] Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. [5]


Solubility (25°C)

In vitro DMSO 100 mg/mL (114.27 mM)
Ethanol 28 mg/mL (31.99 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 875.09


CAS No. 70288-86-7
Storage powder
in solvent
Synonyms MK933

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03690453 Not yet recruiting Healthy University of Oxford January 3 2019 Phase 4
NCT03570814 Not yet recruiting Trachoma|Lymphatic Filariases London School of Hygiene and Tropical Medicine|Armauer Hansen Research Institute Ethiopia|Federal Ministry of Health Ethiopia November 2018 Phase 4
NCT03676140 Not yet recruiting Trachoma|Yaws|Lymphatic Filariases|Scabies|Strongyloidiasis Lihir Medical Centre|London School of Hygiene and Tropical Medicine October 2018 Phase 3
NCT03527732 Not yet recruiting Trichuriasis Jennifer Keiser|Côte d''Ivoire: Centre Suisse de Recherches Scientifiques en Côte d''Ivoire (CSRS)|Lao PDR: National Institute of Public Health (NIOPH)|Pemba Tanzania: Public Health Laboratory Ivo de Carneri|Swiss Tropical & Public Health Institute September 2018 Phase 2|Phase 3
NCT03664063 Not yet recruiting Lymphatic Filariasis|Yaws|Trauma Lihir Medical Centre September 2018 Phase 2
NCT03517462 Enrolling by invitation Onchocerciasis Washington University School of Medicine|Case Western Reserve University|University of Health and Allied Sciences August 6 2018 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID