Catalog No.S1351 Synonyms: MK933
Molecular Weight(MW): 875.09
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
Purity & Quality Control
Choose Selective Chloride Channel Inhibitors
|Description||Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.|
Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively.  Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons.  Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. 
|In vivo||Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration.  Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. |
-  Wagstaff KM, et al. Biochem J, 2012, 443(3), 851-856.
-  Reiter RJ, et al. Prog Neurobiol, 1998, 56(3), 359-384.
-  Moreno Y, et al. Proc Natl Acad Sci U S A, 2010, 107(46), 20120-20125.
|In vitro||DMSO||100 mg/mL (114.27 mM)|
|Ethanol||28 mg/mL (31.99 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03690453||Not yet recruiting||Healthy||University of Oxford||January 3 2019||Phase 4|
|NCT03570814||Not yet recruiting||Trachoma|Lymphatic Filariases||London School of Hygiene and Tropical Medicine|Armauer Hansen Research Institute Ethiopia|Federal Ministry of Health Ethiopia||November 2018||Phase 4|
|NCT03676140||Not yet recruiting||Trachoma|Yaws|Lymphatic Filariases|Scabies|Strongyloidiasis||Lihir Medical Centre|London School of Hygiene and Tropical Medicine||October 2018||Phase 3|
|NCT03527732||Not yet recruiting||Trichuriasis||Jennifer Keiser|Côte d''Ivoire: Centre Suisse de Recherches Scientifiques en Côte d''Ivoire (CSRS)|Lao PDR: National Institute of Public Health (NIOPH)|Pemba Tanzania: Public Health Laboratory Ivo de Carneri|Swiss Tropical & Public Health Institute||September 2018||Phase 2|Phase 3|
|NCT03664063||Not yet recruiting||Lymphatic Filariasis|Yaws|Trauma||Lihir Medical Centre||September 2018||Phase 2|
|NCT03517462||Enrolling by invitation||Onchocerciasis||Washington University School of Medicine|Case Western Reserve University|University of Health and Allied Sciences||August 6 2018||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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