Catalog No.S1351 Synonyms: MK933
Molecular Weight(MW): 875.09
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
Purity & Quality Control
Choose Selective Chloride Channel Inhibitors
|Description||Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.|
Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively.  Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons.  Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. 
|In vivo||Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration.  Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. |
-  Wagstaff KM, et al. Biochem J, 2012, 443(3), 851-856.
-  Reiter RJ, et al. Prog Neurobiol, 1998, 56(3), 359-384.
-  Moreno Y, et al. Proc Natl Acad Sci U S A, 2010, 107(46), 20120-20125.
|In vitro||DMSO||100 mg/mL (114.27 mM)|
|Ethanol||28 mg/mL (31.99 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03690453||Not yet recruiting||Drug: Ivermectin||Healthy||University of Oxford||February 4 2019||Phase 4|
|NCT03432442||Recruiting||Drug: Ivermectin||Dengue Hemorrhagic Fever||Mahidol University||September 4 2018||Phase 2|
|NCT03717558||Withdrawn||Drug: ivermectin T1|Drug: ivermectin T2|Drug: ivermectin T3||Healthy Volunteers||Pierre Fabre Dermatology||April 30 2018||Phase 1|
|NCT03527732||Recruiting||Drug: Albendazole|Drug: Albendazole and Ivermectin||Trichuriasis||Jennifer Keiser|Centre Suisse de Recherches Scientifiques (CSRS)|Lao Tropical and Public Health Institute|Public Health Laboratory of Pemba Tanzania|Swiss Tropical & Public Health Institute||April 15 2018||Phase 2|Phase 3|
|NCT02963324||Completed||Drug: Ivermectin||Malaria||University Hospital Basel Switzerland||November 2016||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
I would like to use S1351 for in vivo studies via IP injection? Do you have some suggestions?
You could use the following formula for working solution: 5%DMSO + 40%PEG300 + 5% Tween + ddH2O, reaching a concentration of 12.5mg/ml.