Imatinib (STI571) Mesylate

For research use only.

Catalog No.S1026 Synonyms: Gleevec, Glivec, CGP-57148B

159 publications

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.

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Selleck's Imatinib (STI571) Mesylate has been cited by 159 publications

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Biological Activity

Description Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.
Targets
PDGFR [1]
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. [1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. [2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. [3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GIST882 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTpW4o6PiCq NHWxXm9KSzVyPUGuO{DPxE1? M3fPelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwNlEzLz5{NEmwNFIyOjxxYU6=
K562 NWnXV|ZUS3m2b4TvfIlkcXS7IFHzd4F6 M3f3WFI1KGh? MYjJR|UxRTBwMkGg{txO NWm2W5NyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MCF-7 M3\OcGN6fG:2b4jpZ4l1gSCDc4PhfS=> M3H4eFI1KGh? MVvJR|UxRTBwOEOg{txO MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
MDA-MB-23 NFPBXZBEgXSxdH;4bYNqfHliQYPzZZk> Ml\PNlQhcA>? M4TVdWlEPTB;MT64JO69VQ>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
K562r NHjtO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTGTWM2OD1zMNMg{txO MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl|OUSxPEc,OjR7M{m0NVg9N2F-
K562 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlziSWM2OD1yLkC5JO69VQ>? NXfoO2s1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2O|g1OTRpPkG2Olc5PDF2PD;hQi=>
MCF-7 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL4e3p[OTBizszN MoK2OFghcA>? MYLicI9kc3NiY3XscEBxem:uaX\ldoF1cW:wIHnuZ5Jm[XOnIHnu[JVk\WRiYomgRmo{Yg>? Ml[3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{SwN|QoRjJ3Mke0NFM1RC:jPh?=
K-562  NELrdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XwdmlEPTB;MTFOwG0> MoC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{m2OlIoRjJ3MkO5OlYzRC:jPh?=
K562  NXjiRXczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED2[INKSzVyPUCuOeKh|ryP MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl|OUSxPEc,OjR7M{m0NVg9N2F-
PC3  MkH1RZBweHSxc3nzJGF{e2G7 Ml\VNlDjiIoQvF2= MVe0PE84OiCq NFr2WI5qdmO{ZXHz[ZMh[2WubDDzeZJ3cX[jbB?= M3[0U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{i2OlU3Lz5{NUe4OlY2PjxxYU6=
PC3  NXfaPWY1S2WubDDWbYFjcWyrdImgRZN{[Xl? MVqyNQKBkc7:TR?= MY[2MVczKGh? Ml63bY5kemWjc3XzJINmdGxidnnhZoltcXS7 MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
DU145 MV\BdI9xfG:|aYOgRZN{[Xl? M{Pn[lIx6oDLzszN MWq0PE84OiCq M3\kfolv\HWlZYOgZ4VtdCCmZXH0bEBjgSCjcH;weI9{cXN? NV;DcpZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
DU145 NUHOdWV5S2WubDDWbYFjcWyrdImgRZN{[Xl? MV6yNQKBkc7:TR?= NIrFT5c3NTd{IHi= M1jsfIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eR?= NUSwbmd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
Hep G2 NWXoc3lIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNzIN88US=> NVP1NWlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OlMzOzJpPkK1PFY{OjN{PD;hQi=>
T47D  Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTVyIN88US=> MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh4M{KzNkc,OjV6NkOyN|I9N2F-
EOL-1 MlrXR5l1d3SxeHnjbZR6KGG|c3H5 M3zXUFczKGi{cx?= MkLwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSW9NNTFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6wNFAzKM7:TT6= NVj1PGp6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
EOL-1 NILUWFRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFr0fZc4OiCqcoO= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEWRTD2xJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6wNFEh|ryPLh?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
GISTT1 NHHlSWdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2rBW|czKGi{cx?= MlXGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJSWPUWFEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlAxOyEQvF2u MkPkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
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K562 M3HUc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGmvYYTpcoljNXKnc3nzeIFvfCCNNU[yJINmdGy|LDDJR|UxKD1iMD6wNFYxPSEQvF2u NWfWfo51RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGzO|Y2QDdpPkKxN|c3PTh5PD;hQi=>
GISTT1 NUTaR5NbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4Swd|czKGi{cx?= M32zTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgZ2tKXCCmZYDlcoRmdnRiaIXtZY4hT0mVVGSxJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wNFgh|ryPLh?= M{TqbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
GISTT1 NIjGdohCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlvDO|IhcHK| NGTvdGlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3RVOSClZXzsd{Bu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xODhizszNMi=> M3e4eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 MWHGeY5kfGmxbjDhd5NigQ>? MWC3NkBpenN? M1u1fWlvcGmkaYTpc44hd2ZiS1nUJIlvKGi3bXHuJGdKW1SWMTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMD6wNUDPxE1w NYrXbHFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O|MyPTNpPkKzO|c{OTV|PD;hQi=>
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TF1 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MkT3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGYyKGOnbHzzJIV5eHKnc4Ppcoch[y2NSWSgcZV1[XSrb36gZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImsJGlEPTBiPTCwMlAyOyEQvF2u M3;qWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkKxNlAyLz5{MkKyNVIxOTxxYU6=
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GIST882 NEDBVYxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXjKPWpJPzJiaILz Mk\rRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJSWPUPFgzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlAyPCEQvF2u MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
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GIST882 M4DacWZ2dmO2aX;uJIF{e2G7 NHPvWGdKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiYYX0c5Bpd3OyaH;yfYxifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGK7IFXMTXNCNCCLQ{WwJF0hOC5yOUeg{txONg>? MlXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O|EoRjJ|NkGxO|cyRC:jPh?=
insect NXy2O4ZvTnWwY4Tpc44h[XO|YYm= NE\qcIY{OCCvaX7z NYDVdZdZUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDD3bYxlKHS7cHWgRWJNOSCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMEm4NkDPxE1w M4TqcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
K562 NVPKbotmS3m2b4TvfIlkcXS7IHHzd4F6 NGr1cY04OiCqcoO= M33Vc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6xJO69VS5? NUf0co95RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
primary leukemia cells NH;qV|REgXSxdH;4bYNqfHliYYPzZZk> MlHEO|IhcHK| NIm0SlFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3Orbnege4lt\CC2eYDlJGZNXDNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEmFNUCgQUAxNjFizszNMi=> NH:5[3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
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K562 MYDDfZRwfG:6aXPpeJkh[XO|YYm= NX[5OoJwOjRiaILz NXXLSZJiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zIN88UU4> M4nmTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkOyPVM2Lz5{Mk[zNlk{PTxxYU6=
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BAF3 NF3G[JBHfW6ldHnvckBie3OjeR?= NUnRenl7PzJiaILz MWTJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBNPTd4UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>? NVO4W5NuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
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GIST882 MXnGeY5kfGmxbjDhd5NigQ>? MmXHTY5pcWKrdHnvckBw\iCNSWSgT|Y1OkVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBCXFBvZHXwcIV1cW:wIHHzd4F6NCCLQ{WwJF0hOC5zMEig{txONg>? M2nmdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkGxO|cyLz5{M{[xNVc4OTxxYU6=
K562 NI\kbmFEgXSxdH;4bYNqfHliYYPzZZk> MVrDfZRwfG:6aXOg[YZn\WO2IHnuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjFzIN88UU4> M2XOblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
KU812 M4npRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mo\qO|IhcHK| NHLZcW5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4yOSEQvF2u M1PDV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BA/F3 M4K1[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7 Mo\PO|IhcHK| NWL6N44{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhUDN7NmCgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVEh|ryPLh?= M1ruOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BAF3 NG\uPGxHfW6ldHnvckBie3OjeR?= MnXGO|IhcHK| NX\1fpF[UW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgR3NHOVJiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMTFOwG0v NGLh[oQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
32D NUexN5ZMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlfNOFghcHK| NHPOT2xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAh[2WubIOg[ZhxemW|c3nu[{BD[3JvYXLsJIF{e2W|c3XkJIF{KHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVEzKM7:TT6= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
insect cells NWHnZ|lqTnWwY4Tpc44h[XO|YYm= MYmzNEBucW6| NF\EZ4pKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhVTN3MWSgcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR|UxKD1iMD6xNVQ{KM7:TT6= M4fOOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
insect cells MkPpSpVv[3Srb36gZZN{[Xl? MVKzNEBucW6| MmHNTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJHEzPTKKIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMUG1JO69VS5? NHPPdZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562 MoO2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYe3NkBpenN? NEHsbo9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlEzKM7:TT6= NGXnfo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
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Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-STAT5 / STAT5; 

PubMed: 18981115     


For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖

p-ZAP70 / ZAP70 / p-LAT / LAT; 

PubMed: 18981115     


For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 

18981115
Immunofluorescence
RelB; 

PubMed: 20371728     


Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry 

Cortactin / F-actin; 

PubMed: 20937825     


NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜

20371728 20937825
Growth inhibition assay
Cell viability ; 

PubMed: 28435223     


(C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺

28435223
In vivo Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. [5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. [6]

Protocol

Kinase Assay:[1]
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PDGF receptor kinase activity:

PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl2). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-33P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:[3]
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  • Cell lines: BON-1 cells and NCI-H727 cells
  • Concentrations: ~100 μM
  • Incubation Time: 48 hours
  • Method: BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively.
    (Only for Reference)
Animal Research:[5]
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  • Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female).
  • Dosages: 70 or 100 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 118 mg/mL (200.09 mM)
Water 118 mg/mL (200.09 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 589.71
Formula

C29H31N7O.CH4SO3

CAS No. 220127-57-1
Storage powder
in solvent
Synonyms Gleevec, Glivec, CGP-57148B
Smiles CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02687425 Unknown status Drug: Pioglitazone|Drug: imatinib mesylate Leukemia Myelogenous Chronic BCR-ABL Positive Meng Li|Tongji Hospital February 2016 Phase 2
NCT02303899 Unknown status Drug: Gemcitabine|Drug: Imatinib mesylate Mesothelioma Malignant Istituto Clinico Humanitas November 2014 Phase 2
NCT01898377 Terminated Drug: Imatinib mesylate Mycophenolate mofetil Chronic Graft-versus-host Disease Seoul National University Hospital August 2013 Phase 2
NCT02891395 Completed Drug: Imatinib Mesylate and Nilotinib Graft Versus Host Disease University Hospital Lille|Novartis December 24 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID