Imatinib (STI571) Mesylate

Name: Imatinib (STI571) Mesylate
Brand: Selleck Chemicals
SKU: S1026
Rating: 5 (163 reviews)

For research use only.

Catalog No.S1026 Synonyms: Gleevec, Glivec, CGP-57148B

163 publications

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.

Selleck's Imatinib (STI571) Mesylate has been cited by 163 publications

Science, 2020, 370(6513)eabc2754

PubMed: 33004676 ( click the link to review the publication )

Cell Stem Cell, 2020, 10;S1934-5909(20)30144-2

PubMed: 32413332 ( click the link to review the publication )

Cell Metab, 2018, 28(6):817-832

PubMed: 30244971 ( click the link to review the publication )

Cancer Cell, 2014, 26(6):840-50

PubMed: 25490448 ( click the link to review the publication )

Cell Stem Cell, 2012, 10(2):210-7

PubMed: 22305570 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab011

PubMed: 33438013 ( click the link to review the publication )

Hum Mol Genet, 2021, ddab014

PubMed: 33450762 ( click the link to review the publication )

Cancer Sci, 2021, 112(2):655-667

PubMed: 33247506 ( click the link to review the publication )

Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

PubMed: 33403501 ( click the link to review the publication )

Blood, 2020, 8 pii: blood

PubMed: 32270193 ( click the link to review the publication )

Clin Cancer Res, 2020, 21;clincanres31422019

PubMed: 32439698 ( click the link to review the publication )

Genome Med, 2020, 18;12(1):17

PubMed: 32070411 ( click the link to review the publication )

Cancer Res, 2020, canres.1992.2020

PubMed: 33203698 ( click the link to review the publication )

Cell Rep, 2020, 24;30(12):3951-3963 e4

PubMed: 32209458 ( click the link to review the publication )

J Hematol Oncol, 2020, 13(1):80

PubMed: 32552902 ( click the link to review the publication )

Cancers (Basel), 2020, 25;12(5)

PubMed: 32344828 ( click the link to review the publication )

Cancers (Basel), 2020, 13;12(2) pii: E436

PubMed: 32069833 ( click the link to review the publication )

Cancers (Basel), 2020, 12(6):E1674

PubMed: 32599808 ( click the link to review the publication )

PLoS Pathog, 2020, 16(8):e1008823

PubMed: 32845931 ( click the link to review the publication )

Br J Cancer, 2020, 10.1038/s41416-020-0952-1

PubMed: 32572172 ( click the link to review the publication )

Aging (Albany NY), 2020, 12(17):17662-17680

PubMed: 32927433 ( click the link to review the publication )

Front Bioeng Biotechnol, 2020, 20;8:482

PubMed: 32509756 ( click the link to review the publication )

Front Oncol, 2020, 12;10:696

PubMed: 32528877 ( click the link to review the publication )

J Cell Mol Med, 2020, 10.1111/jcmm.15830

PubMed: 32914934 ( click the link to review the publication )
Int J Mol Sci, 2020, 21(1)

PubMed: 31948066 ( click the link to review the publication )

Sci Rep, 2020, 10(1):11269

PubMed: 32647179 ( click the link to review the publication )

Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

Oncol Rep, 2020, 44(5):2152-2164

PubMed: 32901871 ( click the link to review the publication )

Drug Des Devel Ther, 2020, 12;14:1799-1811

PubMed: 32494122 ( click the link to review the publication )

J Pharm Biomed Anal, 2020, 195:113864

PubMed: 33387839 ( click the link to review the publication )

J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

PubMed: 33165739 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

FEBS Open Bio, 2020, 10.1002/2211-5463.13052

PubMed: 33289342 ( click the link to review the publication )

bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )

Immun Inflamm Dis, 2020, 10.1002/iid3.383

PubMed: 33350598 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 529(3):699-706

PubMed: 32736695 ( click the link to review the publication )

Ann N Y Acad Sci, 2020, 1467(1):77-93

PubMed: 31930541 ( click the link to review the publication )

J Cell Mol Med, 2020, 10.1111/jcmm.15612

PubMed: 32667731 ( click the link to review the publication )

J Pers Med, 2020, 10(4)E234

PubMed: 33212994 ( click the link to review the publication )

Hemasphere, 2020, 4(6):e497

PubMed: 33196013 ( click the link to review the publication )

Neoplasia, 2020, 22(10):470-483

PubMed: 32818841 ( click the link to review the publication )

Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

PubMed: 33144287 ( click the link to review the publication )

Nat Cell Biol, 2019, 21(6):778-790

PubMed: 31160710 ( click the link to review the publication )

Mol Cell, 2019, 75(2):252-266

PubMed: 31202577 ( click the link to review the publication )

Autophagy, 2019, 15(12):2076-2090

PubMed: 30929559 ( click the link to review the publication )

Cell Rep, 2019, 29(13):4471-4481.e6

PubMed: 31875554 ( click the link to review the publication )

Elife, 2019, 8e48725

PubMed: 31385803 ( click the link to review the publication )
J Exp Clin Cancer Res, 2019, 18;38(1):85

PubMed: 30777101 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)E2043

PubMed: 31861239 ( click the link to review the publication )

Gastric Cancer, 2019, 10.1007/s10120-019-00977-1

PubMed: 31197522 ( click the link to review the publication )

Hum Reprod, 2019, 34(3):506-518

PubMed: 30597012 ( click the link to review the publication )

J Cell Mol Med, 2019, 23(12):8314-8327

PubMed: 31576676 ( click the link to review the publication )

Sci Rep, 2019, 9(1):1897

PubMed: 30760778 ( click the link to review the publication )

Eur J Pharmacol, 2019, 17:172559

PubMed: 31325435 ( click the link to review the publication )

PLoS One, 2019, 14(10):e0224237

PubMed: 31618259 ( click the link to review the publication )

Int J Med Sci, 2019, 16(8):1149-1156

PubMed: 31523178 ( click the link to review the publication )

Cancer Invest, 2019, 37(2):99-112

PubMed: 30836770 ( click the link to review the publication )

Res Vet Sci, 2019, 124:1-9

PubMed: 30716585 ( click the link to review the publication )

JCI Insight, 2019, 4(23)131434

PubMed: 31622281 ( click the link to review the publication )

Front Immunol, 2019, 10:1876

PubMed: 31447858 ( click the link to review the publication )

Nat Biomed Eng, 2018, 2(8):578-588

PubMed: 31015631 ( click the link to review the publication )

Sci Transl Med, 2018, 10(427)

PubMed: 29437150 ( click the link to review the publication )

Acta Neuropathol, 2018, 135(5):779-798

PubMed: 29305721 ( click the link to review the publication )

Blood, 2018, 131(14):1532-1544

PubMed: 29437554 ( click the link to review the publication )

Clin Cancer Res, 2018, 1;24(1):145-157

PubMed: 29070525 ( click the link to review the publication )

Cell Rep, 2018, 23(11):3127-3136

PubMed: 29898385 ( click the link to review the publication )

Elife, 2018, 7e36656

PubMed: 29901437 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 25;37(1):170

PubMed: 30045750 ( click the link to review the publication )

Cell Death Discov, 2018, 4:48

PubMed: 29707241 ( click the link to review the publication )

Front Immunol, 2018,

PubMed: 30127787 ( click the link to review the publication )

Endocr Relat Cancer, 2018, 25(4):471-480

PubMed: 29440231 ( click the link to review the publication )
Neoplasia, 2018, 20(8):857-870

PubMed: 30025229 ( click the link to review the publication )

Pharmacol Res, 2018, 133:121-131

PubMed: 29730267 ( click the link to review the publication )

Eur J Med Chem, 2018, 154:101-109

PubMed: 29778892 ( click the link to review the publication )

Cancer Sci, 2018, 109(9):2792-2800

PubMed: 29957833 ( click the link to review the publication )

J Cell Physiol, 2018, 233(9):7467-7479

PubMed: 29663362 ( click the link to review the publication )

J Cell Sci, 2018,

PubMed: 29487179 ( click the link to review the publication )

Biochem Pharmacol, 2018, 10.1016/j.bcp.2018.10.011

PubMed: 30342021 ( click the link to review the publication )

Toxicol Sci, 2018, 165(1):232-243

PubMed: 30165626 ( click the link to review the publication )

Cell Signal, 2018, 51:191-198

PubMed: 30075184 ( click the link to review the publication )

PLoS One, 2018, 13(2):e0191890

PubMed: 29389967 ( click the link to review the publication )

Biochem Biophys Res Commun, 2018, 502(1):110-115

PubMed: 29787755 ( click the link to review the publication )

Int J Clin Exp Pathol, 2018, 11(1):179-188

PubMed: 31938099 ( click the link to review the publication )

Hemasphere, 2018, 2(3):e41

PubMed: 31723769 ( click the link to review the publication )

Nat Commun, 2017, 1;8(1):1232

PubMed: 29089541 ( click the link to review the publication )

Dev Cell, 2017, 42(2):117-129

PubMed: 28689759 ( click the link to review the publication )

Theranostics, 2017, 7(5):1333-1345

PubMed: 28435469 ( click the link to review the publication )

Cell Rep, 2017,

PubMed: 28564604 ( click the link to review the publication )

Cancer Lett, 2017, 393:113-124

PubMed: 28153790 ( click the link to review the publication )

Cell Death Dis, 2017, 8(10):e3117

PubMed: 29022905 ( click the link to review the publication )

Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(4):671-680

PubMed: 28138031 ( click the link to review the publication )

Sci Rep, 2017,

PubMed: 28638122 ( click the link to review the publication )

Exp Cell Res, 2017, 353(2):72-78

PubMed: 28267438 ( click the link to review the publication )

BMC Cancer, 2017,

PubMed: 28806950 ( click the link to review the publication )
Bioconjug Chem, 2017, 28(10):2608-2619

PubMed: 28903003 ( click the link to review the publication )

Molecules, 2017, 22(12)

PubMed: 29206199 ( click the link to review the publication )

Reprod Fertil Dev, 2017, 29(7):1356-1368

PubMed: 27279472 ( click the link to review the publication )

Oncotarget, 2017, 8(54):91841-91859

PubMed: 29190880 ( click the link to review the publication )

Oncotarget, 2017, 8(27):43662-43677

PubMed: 28599273 ( click the link to review the publication )

Cell Stem Cell, 2017, 20(2):233-246

PubMed: 27989769 ( click the link to review the publication )

Cell, 2017, 170(3):507-521

PubMed: 28735753 ( click the link to review the publication )

Blood, 2016, 28;127(17):2131-43

PubMed: 26864341 ( click the link to review the publication )

Hepatology, 2016, 64(2):488-500

PubMed: 27015352 ( click the link to review the publication )

EMBO Mol Med, 2016, 1;8(2):105-16

PubMed: 26758680 ( click the link to review the publication )

Stem Cell Res, 2016, 16(3):795-806

PubMed: 27161312 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(10):2302-2313

PubMed: 27474148 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(1):94-105

PubMed: 26637365 ( click the link to review the publication )

Mol Pharm, 2016, 13(10):3457-3467

PubMed: 27560921 ( click the link to review the publication )

Traffic, 2016, 17(4):351-68

PubMed: 26650385 ( click the link to review the publication )

Cancer Sci, 2016, 107(6):782-90

PubMed: 27002306 ( click the link to review the publication )

Oncol Rep, 2016, 35(1):197-204

PubMed: 26499059 ( click the link to review the publication )

Mol Vis, 2016, 22:1213-1220

PubMed: 27746675 ( click the link to review the publication )

Oncotarget, 2016, 7(29):45916-45925

PubMed: 27322141 ( click the link to review the publication )

Oncotarget, 2016, 7(18):26709-23

PubMed: 27050374 ( click the link to review the publication )

Nat Commun, 2015, 6:7002

PubMed: 25926053 ( click the link to review the publication )

J Clin Invest, 2015, 125(6):2317-34

PubMed: 25915587 ( click the link to review the publication )

Nat Commun, 2015, 6:8481

PubMed: 26412466 ( click the link to review the publication )

Genes Dev, 2015, 29(7):732-45

PubMed: 25838542 ( click the link to review the publication )
Cell Rep, 2015, 10.1016/j.celrep.2015.05.012

PubMed: 26051937 ( click the link to review the publication )

Phytother Res, 2015, 29(7):1062-72

PubMed: 25857479 ( click the link to review the publication )

Phytother Res, 2015, 29(3):434-43

PubMed: 25583173 ( click the link to review the publication )

PLoS One, 2015, 10(3):e0120531

PubMed: 25781619 ( click the link to review the publication )

Biomed Res Int, 2015, 2015:368976

PubMed: 25629045 ( click the link to review the publication )

Oncol Lett, 2015, 10(5):2835-2841

PubMed: 26722250 ( click the link to review the publication )

Brain Behav, 2015, 3;5(11):e00359

PubMed: 26664784 ( click the link to review the publication )

Sci Transl Med, 2014, 6(261):261ra152

PubMed: 25378644 ( click the link to review the publication )

Nat Protoc, 2014, 10(1):149-68

PubMed: 25521791 ( click the link to review the publication )

J Clin Invest, 2014, 124(8):3378-90

PubMed: 24960160 ( click the link to review the publication )

Leukemia, 2014, 28(4):977-9

PubMed: 24186003 ( click the link to review the publication )

Oncogene, 2014, 33(2):236-45

PubMed: 23246970 ( click the link to review the publication )

Stem Cells, 2014, 32(9):2324-37

PubMed: 24806995 ( click the link to review the publication )

Mol Cancer Ther, 2014, 13(10):2276-87

PubMed: 25122069 ( click the link to review the publication )

Cancer Cell Int, 2014, 14(1):89

PubMed: 25253994 ( click the link to review the publication )

Int J Oncol, 2014, 44(5):1661-8

PubMed: 24585095 ( click the link to review the publication )

J Alzheimers Dis, 2014, 41(3):729-37

PubMed: 24662099 ( click the link to review the publication )

PLoS One, 2014, 9(10):e109441

PubMed: 25279552 ( click the link to review the publication )

PLoS One, 2014, 9(1):e84900

PubMed: 24454763 ( click the link to review the publication )

Biochem Biophys Res Commun, 2014, 450(4):1600-5

PubMed: 25026552 ( click the link to review the publication )

Biomed Res Int, 2014, 2014:682010

PubMed: 24524084 ( click the link to review the publication )

Graefes Arch Clin Exp Ophthalmol, 2014, 10.1007/s00417-014-2674-7

PubMed: 24874745 ( click the link to review the publication )

University of Alberta, 2014, Yahya Muhammad Fiteih

PubMed: ( click the link to review the publication )

Cancer Immunol Res, 2014, 2(12):1186-98

PubMed: 25300860 ( click the link to review the publication )
Cancer Res, 2013, 73(12):3661-70

PubMed: 23576565 ( click the link to review the publication )

Pigment Cell Melanoma Res, 2013, 26(4):518-26

PubMed: 23582185 ( click the link to review the publication )

J Mol Cell Cardiol, 2013, 66:177-88

PubMed: 24326234 ( click the link to review the publication )

J Biol Chem, 2013, 288(34):24503-17

PubMed: 23821550 ( click the link to review the publication )

Drug Metab Dispos, 2013, 10.1124/dmd.113.054189

PubMed: 24335466 ( click the link to review the publication )

Proteomics, 2013, 13(23-24):3554-62

PubMed: 24167056 ( click the link to review the publication )

Leuk Res, 2013, 37(11):1532-7

PubMed: 23972517 ( click the link to review the publication )

Sci Transl Med, 2012, 4(131):131ra50

PubMed: 22539774 ( click the link to review the publication )

Leukemia, 2012, 27(4):932-40

PubMed: 23032722 ( click the link to review the publication )

J Invest Dermatol, 2012, 132(7):1850-9

PubMed: 22437314 ( click the link to review the publication )

Biochemistry, 2012, 51(25):5153-9

PubMed: 22681044 ( click the link to review the publication )

PLoS One, 2012, 7(8):e42310

PubMed: 22879938 ( click the link to review the publication )

Exp Hematol, 2012, 41(4):335-45.e3

PubMed: 23287417 ( click the link to review the publication )

Leuk Res, 2012, 37(2):183-9

PubMed: 23218026 ( click the link to review the publication )

Anticancer Res, 2012, 33(1):175-81

PubMed: 23267143 ( click the link to review the publication )

FASEB J, 2011, 25(10):3661-73

PubMed: 21705667 ( click the link to review the publication )

Pharm Res, 2011, 28(2):337-63

PubMed: 20945153 ( click the link to review the publication )

J Pharm Biomed Anal, 2011, 56(2):173-82

PubMed: 21652160 ( click the link to review the publication )

PLoS One, 2010, 5(11):e14143

PubMed: 21152443 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description

Targets

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. ^[1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. ^[2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. ^[3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	NHXU[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M13FZlk3KGh?	MXnJR\|UxRTFwNzFOwG0>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEKxNkc,OjR7MECyNVI9N2F-
K562	M1rRfmN6fG:2b4jpZ4l1gSCDc4PhfS=>		NWLBSndqOjRiaB?=	M4PyO2lEPTB;MD6yNUDPxE1?	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
MCF-7	MX3DfZRwfG:6aXPpeJkhSXO\|YYm=		Mo\nNlQhcA>?	M4rhVGlEPTB;MD64N{DPxE1?	MkjqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
MDA-MB-23	M17ub2N6fG:2b4jpZ4l1gSCDc4PhfS=>		MmP5NlQhcA>?	MYLJR\|UxRTFwODFOwG0>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
K562r	NWizW5c2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M33tO2lEPTB;MUFCpO69VQ>?	NHTyeGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmzPVQyQCd-MkS5N\|k1OTh:L3G+
K562	MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			NFHIfJpGSzVyPUCuNFkh\|ryP	NF[yZYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNk[3PFQyPCd-MU[2O\|g1OTR:L3G+
MCF-7	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWCxNEDPxE1?	NXq5OXFjPDhiaB?=	MlTMZoxw[2u\|IHPlcIwheHKxbHnm[ZJifGmxbjDpcoNz\WG\|ZTDpcoR2[2WmIHL5JGJLO1p?	NInmXoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK3OFA{PCd-MkWyO\|QxOzR:L3G+
K-562	NVPNdYUxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MojvTWM2OD1zIN88US=>	M2PHcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkO5OlYzLz5{NUKzPVY3OjxxYU6=
K562	M3Tlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			NET3SlNKSzVyPUCuOeKh\|ryP	MnHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7M{m0NVgoRjJ2OUO5OFE5RC:jPh?=
PC3	MoL3RZBweHSxc3nzJGF{e2G7	M4LxclIx6oDLzszN	Mmr5OFgwPzJiaB?=	NYLEWYVHcW6lcnXhd4V{KGOnbHygd5Vzfmm4YXy=	NFi1OHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe4OlY2Pid-MkW3PFY3PTZ:L3G+
PC3	NWfabm03S2WubDDWbYFjcWyrdImgRZN{[Xl?	NGP6b3ozOOLCid88US=>	MnvHOk04OiCq	MkXCbY5kemWjc3XzJINmdGxidnnhZoltcXS7	NXHoUGduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O\|g3PjV4PD;hQi=>
DU145	NVG1OWhpSXCxcITvd4l{KEG\|c3H5	MornNlDjiIoQvF2=	MkC5OFgwPzJiaB?=	NHi0cFJqdmS3Y3XzJINmdGxiZHXheIgh[nliYYDvdJRwe2m\|	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
DU145	MYHD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	MXSyNQKBkc7:TR?=	MVG2MVczKGh?	M1\VS4Rm[3KnYYPld{Bk\WyuII\pZYJqdGm2eR?=	M1vNWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{i2OlU3Lz5{NUe4OlY2PjxxYU6=
Hep G2	NVvtOYZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NYn1ZWNJUUN3ME2zNUDPxE1?	NF7kSnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2N\|I{Oid-MkW4OlMzOzJ:L3G+
T47D	M4PNeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MmL4TWM2OD13MDFOwG0>	NVjE[XpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OlMzOzJpPkK1PFY{OjN{PD;hQi=>
EOL-1	MonLR5l1d3SxeHnjbZR6KGG\|c3H5		M2PO[lczKGi{cx?=	M13QWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVQVC1zIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFAxOiEQvF2u	M2fZcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
EOL-1	NXPNc2sxSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NUXEPZJ1PzJiaILz	NE\N[ppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXPUE0yKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gNE4xODFizszNMi=>	NI\EVIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0OFE1QSd-Mkm1OFQyPDl:L3G+
GISTT1	Moe5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NHvCTnU4OiCqcoO=	NHWzS5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3RVOSClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvODB\|IN88UU4>	MknYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Sf9	NEH4b3ZHfW6ldHnvckBie3OjeR?=			M4G5RmJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gZYN1cX[nIIPpeIUhd2ZiTj30[ZJucW6jbDDo[ZhicGm\|dHnkbY5mNXSjZ3fl[EBCSkx{IHX4dJJme3OnZDDpckBVemmlaH;wcJV{cWFibnmgbY5n\WO2ZXSgV4Y6KGOnbHzzJIJ6KGm\|b4To[ZJu[WxidHn0doF1cW:wIHPhcI9zcW2ndILpZ{Bie3OjeTygT4QhRSByLkCwOkDPxE1w	MnzWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUezOFMoRjJzNEG3N\|Q{RC:jPh?=
K562	M13LOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NVfRUoxlSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDpcYF1cW6rYj3y[ZNqe3SjboSgT\|U3OiClZXzsd{whUUN3MDC9JFAvODB4MEWg{txONg>?	NFrhZYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3OlU5Pyd-MkGzO\|Y2QDd:L3G+
GISTT1	NGXyeYpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MoXqO\|IhcHK\|	Mlz4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDjT2lVKGSncHXu[IVvfCCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkCwPEDPxE1w	MnG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
GISTT1	MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUK3NkBpenN?	M3jFWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWHQyKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTBiPTCwMlAxQCEQvF2u	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1	NYDLWXJXTnWwY4Tpc44h[XO\|YYm=		NGrRbnc4OiCqcoO=	NFG2NoZKdmirYnn0bY9vKG:oIFvJWEBqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygS2k2OCB;IECuNFEh\|ryPLh?=	NYD1RlhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O\|MyPTNpPkKzO\|c{OTV\|PD;hQi=>
BAF3	M1\zNmZ2dmO2aX;uJIF{e2G7		M4C5[FczKGi{cx?=	NIf2bVVKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmGucHjhJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUCgQUAxNjBzMEeg{txONg>?	NWnwNY1wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
TF1	MVHDfZRwfG:6aXPpeJkh[XO\|YYm=			MoOxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGYyKGOnbHzzJIV5eHKnc4Ppcoch[y2NSWSgcZV1[XSrb36gZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImsJGlEPTBiPTCwMlAyOyEQvF2u	MmXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
GIST882	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NYjJTG16PzJiaILz	NUDX[XBLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBkU0mWIHTldIVv\GWwdDDoeY1idiCJSWPUPFgzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNE4xOTRizszNMi=>	NFvjepA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
GIST882	NFrMdVhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NIriOZQ4OiCqcoO=	NUTnN\|RtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjBzNDFOwG0v	M1H1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BA/F3	M2X3NGZ2dmO2aX;uJIF{e2G7		M3nFXFczKGi{cx?=	M2LoOGlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6wNVch\|ryPLh?=	NVvhW41XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	NV\0SW84TnWwY4Tpc44h[XO\|YYm=		NGrMXmg4OiCqcoO=	MWTJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoJmfGFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjBzOTFOwG0v	NYHzV5FZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFQyPDlpPkK5OVQ1OTR7PD;hQi=>
BAF3	MVfGeY5kfGmxbjDhd5NigQ>?		NUfDS2RwPzJiaILz	NGfZTGtKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDQSGdHWi2kZYThJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuNFE6KM7:TT6=	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	MmjiRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MnXKO\|IhcHK\|	NHLySHBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUCgQUAxNjB{IN88UU4>	MoXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3	M{m3dGZ2dmO2aX;uJIF{e2G7		MYq3NkBpenN?	NWPIOoJUUW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCFNke0V{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvODJ2OTFOwG0v	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BA/F3	NU\OVXRRSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M3;ibVQ5KGi{cx?=	MlLkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{BD[3JvYXLsJI5m\2G2aY\lJINmdGy\|IHX4dJJme3OrbnegWIVtNVCGR1\SZoV1[SCtaX7hd4Uh[XO\|ZYPz[YQh[XNicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE4xOjdizszNMi=>	Mn7SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
HL60	MY\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MnvjO\|IhcHK\|	NYX4eoxzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC\|dYL2bZZidCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5yMzFOwG0v	NF3JboY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki1NFAxPCd-Mk[4OVAxODR:L3G+
BAF3	M3\2S2Z2dmO2aX;uJIF{e2G7		MnK3O\|IhcHK\|	NWiyeZZ4UW6qaXLpeIlwdiCxZjDoeY1idiC5aXzkJJR6eGViQlPSMWFDVCCneIDy[ZN{\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDFR\|UxKD1iMD6wN\|Qh\|ryPLh?=	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMEixNEc,OjdyMUC4NVA9N2F-
BA/F3	M{PTUGZ2dmO2aX;uJIF{e2G7		MnjyO\|IhcHK\|	NGnVRZlKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmGucHjhJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6wN\|Qh\|ryPLh?=	M{jPclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
BAF3	NUD2OYdoTnWwY4Tpc44h[XO\|YYm=		MkHIO\|IhcHK\|	NHe2O25KdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDQSGdHWi2jbIDoZUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTBiPTCwMlA{PCEQvF2u	NEDt[2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BAF3	M2jV[2Z2dmO2aX;uJIF{e2G7		MlHjO\|IhcHK\|	NEH2dGlKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKFZ3NUnEJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4xOzZizszNMi=>	M2n1N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BA/F3	NEmxTI9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGDES2ZT[mW2YTD0doFve2[nY4Tl[EBud3W\|ZTDCRU9HOyClZXzsd{whUUN3MDC9JFAvODN7IN88UU4>	NHTQSFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
BAF3	M3q4N2Z2dmO2aX;uJIF{e2G7		NH3LOlU4OiCqcoO=	MWLJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAxNjB\|OTFOwG0v	NXGwZZBGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BAF3	NVvwXndHTnWwY4Tpc44h[XO\|YYm=		NWn5XndSPzJiaILz	NH:yXXRKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCCYNUW5SEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wN\|kh\|ryPLh?=	M2r2ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
MDCK2	MU\GeY5kfGmxbjDhd5NigQ>?		M{C2elUhdWmwcx?=	NWHSW3Q2UW6qaXLpeIlwdiCxZjDoeY1idiCPQWTFNU1u\WSrYYTl[EBcOTSfLX3leIZwem2rbjD1dJRic2ViZYjwdoV{e2WmIHnuJJBwdGG{aYrl[EBOTEONMjDj[YxteyCjZoTldkA2KG2rboOgZpkhdGmzdXnkJJNkcW62aXzsZZRqd25iY3;1cpRqdmdiYX7hcJl{cXNuIFnDOVAhRSByLkC0JO69VS5?	NYDZPIY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
GISTT1	NF7acHJEgXSxdH;4bYNqfHliYYPzZZk>		M4\hN\|czKGi{cx?=	M4e5e2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1SWMTDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZJIdG9iYYPzZZktKEeLNUCgQUAxNjB2IN88UU4>	M{jYbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
HEK293	NX23SVBsTnWwY4Tpc44h[XO\|YYm=			NVTub4lxUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKESGUkGg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OCB;IECuNFQ{KM7:TT6=	MkXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
K562	M4XsOWZ2dmO2aX;uJIF{e2G7		Ml3oN\|AhdWmwcx?=	NWrIOJhFUW6qaXLpeIlwdiCxZjDrbY5w[mWjZDDibY5lcW6pIITvJG5SVzJiaX6gbJVu[W5iS{W2NkBk\WyuczDpcoN2[mG2ZXSg[o9zKDNyIH3pcpMh[nliaWTSRXEhemWjZ3XueE1j[XOnZDDtZZN{KHOyZXP0do9u\XS{aXOgcYV1cG:mLDDJR\|UxKD1iMD6wOFMh\|ryPLh?=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
MEG01	NXP2NHpoSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NV;VUHRbPzJiaILz	NFHo[IVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3FS\|AyKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4xPDVizszNMi=>	MkWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3	M3rZR2Z2dmO2aX;uJIF{e2G7		NWfl[2k6PzJiaILz	MVXJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJGw2Pz[SIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6wOFUyKM7:TT6=	MnLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
MO7e	NUH4VIpyTnWwY4Tpc44h[XO\|YYm=			NFP0bVNKdmirYnn0bY9vKG:oIGPDSk1qdmS3Y3XkJJBpd3OyaH;yfYxifGmxbjDv[kBkNUurdDDpckBOVzenIHPlcIx{KGK7IGTSMWZTTVRiYYPzZZktKEmFNUCgQUAxNjB2NjFOwG0v	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR2N{O3PUc,OTh2NEezO\|k9N2F-
BA/F3	MXLGeY5kfGmxbjDhd5NigQ>?		M1P6VVczKGi{cx?=	NGT3dY5KdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDQSGdHWmGucHjhJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkC0OkDPxE1w	MmrDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
K562	Mm\NR5l1d3SxeHnjbZR6KGG\|c3H5		MUO3NkBpenN?	NFL4SGxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFQ6KM7:TT6=	NUjtc4JpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
HEK293	M1fqSmZ2dmO2aX;uJIF{e2G7		NGP5UGgyNjVibXnudy=>	MmXoTY5pcWKrdHnvckBw\iCqdX3hckBOSVSHMT3t[YRq[XSnZDDbNVReNW2ndH\vdo1qdiC3cIThb4Uh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{Bi\nSncjCxMlUhdWmwczDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pIHHuZYx6e2m\|LDDJR\|UxKD1iMD6wOUDPxE1w	NWe0TYRGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
BA/F3	NVj4TIlISW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	NWXWSFZQPSC2bzCxNEB2VQ>?	MkXuOFghcHK\|	NF3ONZRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochXGWuLWPINk1MTCCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjdDC1JJRwKDFyIIXNJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlA2PSEQvF2u	NGPXeno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
HT-29	M2SydGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M3:xUVk3KGi{cx?=	MmK3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKVD2yPUBk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iMD6wOkDPxE1w	NHntS2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS2PVU1Pyd-MUm0Olk2PDd:L3G+
K562	Mni5R5l1d3SxeHnjbZR6KGG\|c3H5			M2L1TWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7LDDJR\|UxKD1iMD6wOkDPxE1w	MlHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NkS1NFMoRjJ4Mk[0OVA{RC:jPh?=
HT-29	NHHENIlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NYDjbWF6QTZiaILz	NXLjWoc3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNE4xPiEQvF2u	NV\BVGR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlQ3PTNpPkK5O\|I1PjV\|PD;hQi=>
JURL-MK1	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MoTLOFghcHK\|	NITROJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFrVVmwuVUtzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBE\WyuLWTpeIVzNUeubzDseY1qdmW\|Y3XueEBk\WyuII\pZYJqdGm2eTDhd5NigSxiR1m1NEA:KDBwME[g{txONg>?	NHf5U3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
BA/F3	NXzrUGlpTnWwY4Tpc44h[XO\|YYm=		NUnvPWZJPzJiaILz	MlHZTY5pcWKrdHnvckBw\iCNaYSgWlU3OERibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlA4KM7:TT6=	NHHVRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
A31	MlWxSpVv[3Srb36gZZN{[Xl?			MnHzTY5pcWKrdHnvckBw\iCSRFfGVoJmfGFiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDBN\|Eh[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlA4OiEQvF2u	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
A31	M3TRNmZ2dmO2aX;uJIF{e2G7			NGjad2JKdmirYnn0bY9vKG:oIHj1cYFvKFCGR1\SZYxxcGFiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDBN\|Eh[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlA4OiEQvF2u	NX7jR5dXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
MEG01	MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NH[zdXc4OiCqcoO=	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKFUj3BRmwh\GWyZX7k[Y51KE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6wO\|Qh\|ryPLh?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
MEG01	NFm5VXZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MXm3NkBpenN?	MoLFRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCPRVewNUBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6wO\|Qh\|ryPLh?=	NVjxW4xPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
Ba/F3	NHjyeItHfW6ldHnvckBie3OjeR?=		NXm0cYxyPDhiaILz	MorPTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCJMkWwTEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK\|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvODd5MTFOwG0v	M16wSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
BA/F3	NXewZppCSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	NWHvRnd{PSC2bzCxNEB2VQ>?	Mn7hOFghcHK\|	M4jIS2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BV\WxvU1izMXNJOi2NRDDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEA2KHSxIEGwJJVOKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB6ODFOwG0v	NWXoO5NVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ\|PD;hQi=>
BA/F3	M2[ze2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnfPOFghcHK\|	NUDCdoFWT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzD3bYxlNXS7cHWgRoNzNUGkbDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD6wPFkh\|ryPLh?=	NVzzTIxzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[1OlIzOTdpPkK2OVYzOjF5PD;hQi=>
K562	NXnUSVRyTnWwY4Tpc44h[XO\|YYm=		MmLCN\|AhdWmwcx?=	MVnJcohq[mm2aX;uJI9nKGurbn;i[YFlKGKrbnTpcochfG9iRFTSNUBqdiCqdX3hckBMPTZ{IHPlcIx{KGmwY4XiZZRm\CCob4KgN\|AhdWmwczDifUBqXFKDUTDy[YFo\W62LXLhd4VlKG2jc4Ogd5Bm[3S{b33leJJq[yCvZYToc4QtKEmFNUCgQUAxNjB7IN88UU4>	MlXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
Ba/F3	MmHkSpVv[3Srb36gZZN{[Xl?		M{\aXVQ5KGi{cx?=	NEnkSpNKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDCR3IuSUKOMTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgRpJqfGWOaXfoeEBtfWOrZnXyZZNmKGG\|c3H5MEBIUTVyIE2gNE4xQTB3IN88UU4>	NHrncm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
BA/F3	M1j4WGN6fG:2b4jpZ4l1gSCjc4PhfS=>		Ml;ZOFghcHK\|	M1z0ZmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgOFghcHK\|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFAvODl{IN88UU4>	NF24c5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
GIST882	MoDGSpVv[3Srb36gZZN{[Xl?			MWrJcohq[mm2aX;uJI9nKGi3bXHuJGtKXCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[nliRVzJV2EtKEmFNUCgQUAxNjB7NzFOwG0v	NHTNd3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
GIST882	MlXxSpVv[3Srb36gZZN{[Xl?			MUnJcohq[mm2aX;uJI9nKEuLVDDLOlQzTSCvdYThcpQh[XW2b4Doc5NxcG:{eXzheIlwdiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIJ6KEWOSWPBMEBKSzVyIE2gNE4xQTdizszNMi=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O\|E9N2F-
insect	NXnUZok1TnWwY4Tpc44h[XO\|YYm=		MnnzN\|AhdWmwcx?=	NWS0SGoyUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDD3bYxlKHS7cHWgRWJNOSCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMEm4NkDPxE1w	NI[3bGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	NInoZo5EgXSxdH;4bYNqfHliYYPzZZk>		MlfJO\|IhcHK\|	MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMTFOwG0v	NWf0ZmpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
primary leukemia cells	NVv3OZpLS3m2b4TvfIlkcXS7IHHzd4F6		M4HrVlczKGi{cx?=	MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5Nqdmdid3ns[EB1gXCnIF\MWFMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGlEPTBiPTCwMlEh\|ryPLh?=	MnXEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
BV173	M{fXZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M{mzWVQ5KGi{cx?=	M3O5XWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQm[xO\|Mh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPlcIwuXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBIUTVyIE2gNE4yKM7:TT6=	M1HwTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGxNVU6Lz5{N{CxNVE2QTxxYU6=
BAF3	NVrqNnhmTnWwY4Tpc44h[XO\|YYm=		M1;EOVczKGi{cx?=	MoD3TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBNPTZ5UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOC5zIN88UU4>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
K562	Mn7TR5l1d3SxeHnjbZR6KGG\|c3H5		NF6yeFUzPCCqcoO=	Mme4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE4yKM7:TT6=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ\|MkmzOUc,OjJ4M{K5N\|U9N2F-
BA/F3	M2fNXWZ2dmO2aX;uJIF{e2G7		NF61e5o4OiCqcoO=	M4TZcGlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIGDES2ZT[mW2YTCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>?	NHfRPZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BAF3	NH7TWYpHfW6ldHnvckBie3OjeR?=		MX63NkBpenN?	M3vjUmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHOtT2lVKEx3N{\QJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkGwNkDPxE1w	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	M2XWd2FvfGmycn;sbYZmemG2aY\lJIF{e2G7			NXrTNFJ4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{NCCLQ{WwJF0hOC5zMEig{txONg>?	NUnIW5NORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882	M3\yXWZ2dmO2aX;uJIF{e2G7			MkD0TY5pcWKrdHnvckBw\iCNSWSgT\|Y1OkVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBCXFBvZHXwcIV1cW:wIHHzd4F6NCCLQ{WwJF0hOC5zMEig{txONg>?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZzMUe3NUc,OjN4MUG3O\|E9N2F-
K562	MknrR5l1d3SxeHnjbZR6KGG\|c3H5			M2L5b2N6fG:2b4jpZ{Bm\m[nY4SgbY4hUzV4MjDj[YxteyxiSVO1NEA:KDBwMUGg{txONg>?	M{PaRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
KU812	M{\3b2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NXPlOJFUPzJiaILz	NVu2R\|ZuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=>	NHHFTYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BA/F3	NFjQZ2hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MkTzO\|IhcHK\|	MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDIN\|k3WCCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5zMTFOwG0v	MmnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
BAF3	Mnv2SpVv[3Srb36gZZN{[Xl?		NHX2UIg4OiCqcoO=	M{G5fGlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=>	MmPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
32D	MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MmPqOFghcHK\|	MlzTRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SB\|MlSgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCyMkGwJINmdGy\|IHX4dJJme3OrbnegRoNzNWGkbDDhd5Nme3OnZDDhd{Bxem:uaX\ldoF1cW:wIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkGxNkDPxE1w	M3P4eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
insect cells	Mo\ySpVv[3Srb36gZZN{[Xl?		M4XYSFMxKG2rboO=	MYPJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgUVM2OVRibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN\|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hOC5zMUSzJO69VS5?	M1fGRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
insect cells	NXvtS2RUTnWwY4Tpc44h[XO\|YYm=		NILsS3E{OCCvaX7z	NWH2eppwUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKFF{NULIJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuNVE2KM7:TT6=	NHzSXIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M3LJNFczKGi{cx?=	M33xbWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgRmNTNUGETDDk[ZBmdmSnboSgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNVIh\|ryPLh?=	M2XFZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BA/F3	NVH4c\|hHSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NETyc\|Y4OiCqcoO=	NUPhSZZRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhVTJ2NG[gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVI6KM7:TT6=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
K562	M4K4OmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MkfoO\|IhcHK\|	NELTNGZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlE1KM7:TT6=	NIfPRlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
HEK293	Mo\jSpVv[3Srb36gZZN{[Xl?			M{jRRWlvcGmkaYTpc44hd2ZiYYX0c5Bpd3OyaH;yfYxifGmxbjDv[kBFTFJ{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkG0NUDPxE1w	NHTMfmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
K562	M3PLfWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MUi3NkBpenN?	MnvaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xOFch\|ryPLh?=	M2C4cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BAF3	M3zpOGZ2dmO2aX;uJIF{e2G7		Ml;4O\|IhcHK\|	NV71Rnd7UW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCDOEK5VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvOTR6MjFOwG0v	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
Ba/F3	MXPGeY5kfGmxbjDhd5NigQ>?		NHzsS5Q1QCCqcoO=	MW\Jcohq[mm2aX;uJI9nKEKFUj3BRmwyKEV\|NUXHJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W\|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGJEWi2DQlyxMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgRpJqfGWOaXfoeEBtfWOrZnXyZZNmKGG\|c3H5MEBIUTVyIE2gNE4yPDlizszNMi=>	NX;q[Jl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
KU812	NVrVWpdmSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NFjyTnM4OiCqcoO=	NHn5bW5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gNE4yPiEQvF2u	M4P3e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
KU812	NYL0eW1QSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MXq3NkBpenN?	NFrJdpFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNE4yPiEQvF2u	NUf4U2NmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
A10	M3TqSGZ2dmO2aX;uJIF{e2G7		NYn4XIU5PjhiaILz	MlriTY5pcWKrdHnvckBw\iCSRFfGVk1j\XSjIHTybZZmdiCycn;sbYZmemG2aX;uJI9nKHKjdDDBNVAh[2WubIOgZYZ1\XJiNkigbJJ{KGmwIIDy[ZNmdmOnIH;mJJJifCC{ZXPvcYJqdmGwdDDQSGdHNUKEIHL5JINmdGxidHn0[ZIu\2yxIHz1cYlv\XOlZX7j[UBie3OjeTygTWM2OCB;IECuNVYzKM7:TT6=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzVyMkewNEc,Ojd3MEK3NFA9N2F-
KU812	NV[2XZBbSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYG3NkBpenN?	M{W3O2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOgcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuNVY{KM7:TT6=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
K562	MU\DfZRwfG:6aXPpeJkh[XO\|YYm=			NFL2[VFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zNzFOwG0v	NFzHVoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
K562	NGfoUFlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NV75[XozSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBIUTVyIE2gNE4yPyEQvF2u	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|OU[3OEc,OjJ2M{m2O\|Q9N2F-
insect cells	M1zF[2Z2dmO2aX;uJIF{e2G7		M{jSN\|MxKG2rboO=	M2Pib2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiQVLMNUBJOzl4UDDteZRidnRiZYjwdoV{e2WmIHnuJIlve2WldDDj[YxteyCjZoTldkA{OCCvaX7zJIJ6KE[URWSgZZN{[XluIFnDOVAhRSByLkG3N\|kh\|ryPLh?=	NUf3OopMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	M1zp[mN6fG:2b4jpZ4l1gSCjc4PhfS=>			M3vJTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEt3NkKgZ4VtdHNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE4yQCEQvF2u	M2X6[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUeyNFg5Lz5zN{W3NlA5QDxxYU6=
K562	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			MkjtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDLOVYzKGOnbHzzMEBKSzVyIE2gNE4yQDJizszNMi=>	NUPIbWJ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zN\|I1PDBpPkG2N\|MzPDRyPD;hQi=>
32D	NYrzeXUyS3m2b4TvfIlkcXS7IHHzd4F6			M{PiVGN6fG:2b4jpZ{Bi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAhSmO{LXHicEwhUUN3MDC9JFAvOTlizszNMi=>	NFuwV2M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
BA/F3	MWrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVfCdIgyPDhiaILz	NH\YUWlCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE4yQSEQvF2u	M{\V[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
BA/F3	Ml32RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NGjRNYg1QCCqcoO=	MlXMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAhSmO{LXHicEBie3Onc4Pl[EBieyCycn;sbYZmemG2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlE6KM7:TT6=	NHfqbWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
BA/F3	MWXGeY5kfGmxbjDhd5NigQ>?		M2fUclczKGi{cx?=	NVnWSmY4UW6qaXLpeIlwdiCxZjDLbZQh\XixbjC5JGF[PTB{IITvJFUxOyCrboPldpRqd25ibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlE6OiEQvF2u	NIfGXVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
32D	MUHGeY5kfGmxbjDhd5NigQ>?			NVL3dplDUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SB\|MlSgZ4VtdHNuIFnDOVAhRSByLkG5OEDPxE1w	NYPpOHhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
K562	NGDSTW9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MmLaOFghcHK\|	NHnR[GRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IFPlcIwuXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBIUTVyIE2gNE4zKM7:TT6=	M3fs[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEGxNVU6Lz5{N{CxNVE2QTxxYU6=
Ba/F3	NXr1[pdoTnWwY4Tpc44h[XO\|YYm=		MUK0PEBpenN?	NF[xfnNKdmirYnn0bY9vKG:oIFLDVk1CSkxzIFW0OVlMKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC5{MEGg{txONg>?	NIDIXFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
BA/F3	M3TTTGZ2dmO2aX;uJIF{e2G7		M4K2blczKGi{cx?=	NWrVOGR2UW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OjCDIH31eIFvfCCjbnSgSFgzOEFibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlIyPiEQvF2u	MlnsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
Sf9	MX7GeY5kfGmxbjDhd5NigQ>?			NXG2VYxHUW6qaXLpeIlwdiCxZjDoeY1idiCOeX6gb4lv[XOnIHX4dJJme3OnZDDpckBU\jliY3XscJMtKEmFNUCgQUAxNjJ{IN88UU4>	NXPWfFV[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezO\|Y3QDBpPkG3N\|c3PjhyPD;hQi=>
K562	MYjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NGPlXWM1QCCqcoO=	NEXhRW1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IITyfZBidiCkbIXlJIR6\SCneHPseZNqd25iYYPzZZktKEmFNUCgQUAxNjJ{IN88UU4>	NILP[489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[yPVg2QSd-Mk[2Nlk5PTl:L3G+
Ba/F	MUPGeY5kfGmxbjDhd5NigQ>?			NH70bVVKdmirYnn0bY9vKG:oIHH1eI9xcG:\|cHjvdplt[XSrb36gc4YhSkOULVHCUFEh\XiycnXzd4VlKGmwIFLhM2Yh[2WubIOsJGlEPTBiPTCwMlIzOSEQvF2u	NWiwRlNKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3	NFPjTlFHfW6ldHnvckBie3OjeR?=			M{HsVGlvcGmkaYTpc44hd2ZiaIXtZY4hSkOULVHCUFEh[XW2b4Doc5NxcG:{eXzheIlwdiCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlIzOSEQvF2u	Mm\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUG3O\|EoRjJ\|NkGxO\|cyRC:jPh?=
BA/F3	NEDaSJRHfW6ldHnvckBie3OjeR?=		Moi5O\|IhcHK\|	NFTzSodKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgUlgzOktibYX0ZY51KGGwZDDZPFI{TCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuNlI{KM7:TT6=	NX3sNJNCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
SF9	NGLhWotHfW6ldHnvckBie3OjeR?=		NHTLV2kyKGi{	M4DYcWlvcGmkaYTpc44hd2ZiQz30[ZJucW6jbDDIbZMufGGpZ3XkJIh2dWGwIFHCUFEh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJHNHQSClZXzsd{B2e2mwZzDUfZIhODJicHXweIll\SCjczDzeYJ{fHKjdHWgcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSCIUlXUJIJie2WmIGqnUJl1\SCjc4PhfUwhUUN3MDC9JFAvOjJ\|IN88UU4>	M2DsfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
NCI-H1703	M3rUNGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MXy3NkBpenN?	Ml35RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCQQ1mtTFE4ODNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHnuJJBz\XOnbnPlJI9nKFCGR1[tRWEh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuNlMh\|ryPLh?=	NE\vNlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0OFE1QSd-Mkm1OFQyPDl:L3G+
CHO	Ml;zSpVv[3Srb36gZZN{[Xl?			NWXVXFJzUW6qaXLpeIlwdiCxZjD3bYxlKHS7cHWgVIxifGWuZYSt[IVzcX[nZDDndo94fGhiZnHjeI9zKHKnY3XweI9zKGKndHGgdIhwe3Cqb4L5cIF1cW:wIHnuJGNJVyClZXzsd{whUUN3MDC9JFAvOjRizszNMi=>	M4D5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MU[2PVUxLz5zMkG2Olk2ODxxYU6=
MEG01	NHixNVdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MXm3NkBpenN?	MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6yOEDPxE1w	MkjMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BA/F3	MX;DfZRwfG:6aXPpeJkh[XO\|YYm=		MnfYO\|IhcHK\|	MniyR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKE1\|NUHUJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjJ2IN88UU4>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
K562	NWjuNJJySW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			Mkn3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|LDDJR\|UxKD1iMD6yOFQh\|ryPLh?=	NGeyfoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
Ba/F3	M3vtUmZ2dmO2aX;uJIF{e2G7		M2jaO\|Q5KGi{cx?=	M{LnT2lvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRkO1PXYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjJ2OTFOwG0v	M{XFZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
K562	MnP6SpVv[3Srb36gZZN{[Xl?		NHXBfGY{OCCvaX7z	MYDJcohq[mm2aX;uJI9nKGurbn;i[YFlKGKrbnTpcochfG9iQVLMJIlvKGi3bXHuJGs2PjJiY3XscJMhcW6ldXLheIVlKG[xcjCzNEBucW6\|IHL5JIlVWkGTIILlZYdmdnRvYnHz[YQhdWG\|czDzdIVkfHKxbXX0dolkKG2ndHjv[EwhUUN3MDC9JFAvOjVizszNMi=>	MkjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
M07e	Mlm3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MmPSOFghcHK\|	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE1yN3WgRoNzNWGkbDDu[YdifGm4ZTDj[YxteyCneIDy[ZN{cW6pIIP0[Y0h[2WubDDmZYN1d3JiYYPz[ZN{\WRiYYOgdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5{NUeg{txONg>?	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
CHO	M4jacWZ2dmO2aX;uJIF{e2G7			Ml[0TY5pcWKrdHnvckBw\iClaHnt[ZJq[yCSRFfGJJJm[2WydH;yJJdqfGhiYz3rbZQh[3m2b4DsZZNucWNiZH;tZYlvKHCqb4PwbI9zgWyjdHnvckBqdiCFSF:gZ4VtdHNuIFnDOVAhRSByLkK2JO69VS5?	M4\wSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MU[2PVUxLz5zMkG2Olk2ODxxYU6=
EM2	NUnqfIR7SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGTEelQ1QCCqcoO=	M2TBb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRV2yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFZXzsMXRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygS2k2OCB;IECuNlYh\|ryPLh?=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
K562	Mn3YRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NUfJNXo6PzJiaILz	NULBVZh3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTBiPTCwMlI3PyEQvF2u	NHe0S5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BAF3	NE\ufpZHfW6ldHnvckBie3OjeR?=		NEj2ZZc4OiCqcoO=	M{jkRmlvcGmkaYTpc44hd2ZiaIXtZY4hSkOUL1HCUEBxOjFyIH\1d4lwdiCycn;0[YlvKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjJ5IN88UU4>	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
K562	NVzFcnF7TnWwY4Tpc44h[XO\|YYm=		NYnlXYhNOzBibXnudy=>	MkG5TY5pcWKrdHnvckBw\iCtaX7vZoVi\CCkaX7kbY5oKHSxIFHSS{BqdiCqdX3hckBMPTZ{IHPlcIx{KGmwY4XiZZRm\CCob4KgN\|AhdWmwczDifUBqXFKDUTDy[YFo\W62LXLhd4VlKG2jc4Ogd5Bm[3S{b33leJJq[yCvZYToc4QtKEmFNUCgQUAxNjJ5MjFOwG0v	M3T5eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiwNlYyLz5{OEK4NFI3OTxxYU6=
KBM5	M{jwUWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NXm5elV5PzJiaILz	MofER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2JOPSClZXzsd{Bp[XKkb4Lpcochf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjhizszNMi=>	M2jafFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUS5OlY2Lz5{MEG0PVY3PTxxYU6=
K562	M{n6Z2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MWq3NkBpenN?	NHPkb49CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOg[ZhxemW\|c3nu[{B4cWymIIT5dIUhSmO{LVHicEBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjJ6IN88UU4>	Mm[zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzOUWxN\|YoRjJ4MUm1NVM3RC:jPh?=
HEK293	MWrGeY5kfGmxbjDhd5NigQ>?			NYPC[HppUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKEOVRkHSJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlI6OSEQvF2u	NFP1WlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
Sf9	MWPGeY5kfGmxbjDhd5NigQ>?			MnPPTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDBZowhc2mwYYPlJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyC3c3nu[{BIT0WDSWnBRXBHU0tiYYOgd5Vje3S{YYTlJIlvKHC{ZYPlcoNmKG:oIGvnZY1u[TN\|UG3BWHAtKEmFNUCgQUAxNjNizszNMi=>	NHPlXII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
K562	NFX2ZYREgXSxdH;4bYNqfHliYYPzZZk>		NEn4[YU4OiCqcoO=	M1vrT2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDYWHQh[XO\|YYmsJGlEPTBiPTCwMlMyKM7:TT6=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzJzNEWxNkc,Ojd{MUS1NVI9N2F-
BA/F3	NWj3[ZFvTnWwY4Tpc44h[XO\|YYm=		NEnmNlE4OiCqcoO=	MVHJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiQUiyPXAhdXW2YX70JIFv\CC\OEKzSEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwM{GyJO69VS5?	NIPWS2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
ALL3	NW\lO4x4S3m2b4TvfIlkcXS7IHHzd4F6			MlHZR5l1d3SxeHnjbZR6KGGpYXnud5QhWGirbHHk[YxxcGmjIHPodo9ud3OxbXWgdI9{cXSrdnWgbJVu[W5iQVzMN{Bk\WyuczDifUBCdGGvYYKgRox2\SCobIXvdoV{[2WwdDDhd5NigSxiSVO1NEA:KDBwM{OzJO69VS5?	NI\2VHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi4PVU1OCd-MUm4PFk2PDB:L3G+
KU812	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			MlzwRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNVUixNkBk\WyuczygTWM2OCB;IECuN\|M4KM7:TT6=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN5NkW4O{c,OjF\|N{[1PFc9N2F-
BA/F3	MWXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUO0PEBpenN?	NEXGe5hCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBCOzN5TjDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwM{O5JO69VS5?	M3HFS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
CML	NVv3PY4xSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOPTDDj[YxteyxiSVO1NEA:KDBwM{Wg{txONg>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJzOUCxOkc,OTl{MUmwNVY9N2F-
HEK293	NYTONlV6TnWwY4Tpc44h[XO\|YYm=		NILRPVMyNjVibXnudy=>	NH;sfXpKdmirYnn0bY9vKG:oIHj1cYFvKE2DVFWyT{1u\WSrYYTl[EBCW1BtIIXweIFs\SCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KHWyIITvJFUxOCC3TTDh[pRmeiBzLkWgcYlveyCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlM2KM7:TT6=	NF;EdWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K0NVAzQSd-MkOyOFExOjl:L3G+
HEK293	NYf5[2NUTnWwY4Tpc44h[XO\|YYm=		MofsNU42KG2rboO=	Ml62TY5pcWKrdHnvckBw\iCqdX3hckBOSVSHMT3t[YRq[XSnZDDBV3AsKHWydHHr[UBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIFnfGW{IEGuOUBucW6\|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOzVizszNMi=>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
M-NFS-60	NG\qSVFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			NV7k[ItLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDNMW5HWy14MDDj[YxteyxiSVO1NEA:KDBwM{W4JO69VS5?	M2OwO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
insect cells	M2\qO2Z2dmO2aX;uJIF{e2G7		NHzORnQ{OCCvaX7z	NIG2VZpKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhTzJ3MFWgcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD6zOVk6KM7:TT6=	NV\hUFA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	NFzwWIpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHLYe204OiCqcoO=	M4THNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGU{PTWJIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkO2NkDPxE1w	M3vFU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BA/F3	NEXwNnpHfW6ldHnvckBie3OjeR?=		NHvlW3Y4OiCqcoO=	MUfJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClLVvJWEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1utPEBie3OjeTygS2k2OCB;IECuN\|ch\|ryPLh?=	NYLld\|g3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFQyPDlpPkK5OVQ1OTR7PD;hQi=>
BAF3	MoXHSpVv[3Srb36gZZN{[Xl?			NFLxTGhKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjN5IN88UU4>	MnziQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562	MXvBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVAhRSByLkO4JO69VS5?	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN5NkW4O{c,OjF\|N{[1PFc9N2F-
K562	MlvTRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M3PFblczKGi{cx?=	MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJJN2en[rdnHsJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlM5KM7:TT6=	MmXXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NUCwNFQoRjJ4OEWwNFA1RC:jPh?=
BA/F3	NWT5[nY5TnWwY4Tpc44h[XO\|YYm=		MXW3NkBpenN?	NVT6eFJRUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlM5KM7:TT6=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BAF3	M1XSRWZ2dmO2aX;uJIF{e2G7		M4C0RVczKGi{cx?=	MYjJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUCgQUAxNjN6MUmg{txONg>?	M3rYWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
K562	MlzRR5l1d3SxeHnjbZR6KGG\|c3H5		MlfHOFghfG9iN{KgbJJ{	NWrqdmp[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSkOULVHCUEBxd3OrdHn2[UBMPTZ{IHPlcIx{KGGodHXyJFQ5KHSxIEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlM5PDRizszNMi=>	M3\VblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{i5OFI6Lz5{Mke4PVQzQTxxYU6=
K562	M{TSNmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NEPJOnc4OiCqcoO=	MojGR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyIE2gNE4{QSEQvF2u	M1fFOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUOyN\|E{Lz5{MkmzNlMyOzxxYU6=
BA/F3	MV3GeY5kfGmxbjDhd5NigQ>?		MWm3NkBpenN?	MYTJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiVk[1OGEhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkO5NkDPxE1w	MkjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	NWnhZ4ttSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	MljwOUB1dyBzMDD1US=>	Ml3vOFghcHK\|	M{Ky[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BPWE1vYXLsJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIF1KDVidH:gNVAhfU1iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwM{mzJO69VS5?	NWfGeZNIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ\|PD;hQi=>
K562	NXP3UpE4TnWwY4Tpc44h[XO\|YYm=			MkfzTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOg[5Jwf3SqIIXzbY5oKE2WVDDhd5NigSxiSVO1NEA:KDBwNDFOwG0v	NHrZeJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEW1Nlc3OCd-MUS1OVI4PjB:L3G+
BAF3	NGnP[pdHfW6ldHnvckBie3OjeR?=		NYTHWHc3PzJiaILz	M1Tnd2lvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG\|c3H5MEBIUTVyIE2gNE41KM7:TT6=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BA/F3	MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MkLnO\|IhcHK\|	NU\lSHF7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhVTN3MWSgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuOFI1KM7:TT6=	MmrPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
KCL22	Mmj3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NHf5epE1QCCqcoO=	NULMOYdFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLR2wzOiClZXzsd{Bi\nSncjC0PEBpenNiYomgR4VtdC2WaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUCgQUAxNjR\|IN88UU4>	NWDUcZVCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
Ba/F3	NXThfYY3TnWwY4Tpc44h[XO\|YYm=		MnvtOFghcHK\|	M{HidWlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiUUK1NmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjR3NTFOwG0v	NHLlRVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
Sf9	MkjwSpVv[3Srb36gZZN{[Xl?			NWLNXVNTUW6qaXLpeIlwdiCxZjDoeY1idiCDYnygb4lv[XOnIHX4dJJme3OnZDDpckBU\jliY3XscJMtKEmFNUCgQUAxNjR5IN88UU4>	Mn76QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd\|N{[2PFAoRjF5M{e2OlgxRC:jPh?=
K562	MV\DfZRwfG:6aXPpeJkh[XO\|YYm=		NGTxcnQ1QCCqcoO=	NVrkfll7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD60O{DPxE1w	NV23TmJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3N\|U5OjZpPkKzO\|M2QDJ4PD;hQi=>
K562	MUjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1jW[VQ5KGi{cx?=	MmDHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkS3JO69VS5?	NEDrNJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3PFc3Pid-MkW3O\|g4PjZ:L3G+
K562	MoXySpVv[3Srb36gZZN{[Xl?			MljNTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFu1OlIh[2WubIOsJGlEPTBiPTCwMlQ4OyEQvF2u	NUKwVFl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
insect cells	NFTOdGpHfW6ldHnvckBie3OjeR?=		M4K4flMxKG2rboO=	NEW3blZKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhTTJ3NVugcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD60PFU5KM7:TT6=	NFfhemk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
Sf9	M1myR2Z2dmO2aX;uJIF{e2G7			MULCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlcY91\SC\|aYTlJI9nKE5vdHXycYlv[WxiaHX4ZYhqe3SrZHnu[U11[WepZXSgRWJNOiCneIDy[ZN{\WRiaX6gWJJq[2ixcHz1d4liKG6rIHnu[oVkfGWmIGPmPUBk\WyuczDifUBqe2:2aHXycYFtKHSrdILheIlwdiClYXzvdolu\XS{aXOgZZN{[XluIFvkJF0hOC53IN88UU4>	NUfmepdkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0NVc{PDNpPkKxOFE4OzR\|PD;hQi=>
primary leukemia cells	MXzDfZRwfG:6aXPpeJkh[XO\|YYm=		NGLpSlE4OiCqcoO=	M2rEeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBzcW2jcomgcIV2c2WvaXGgZ4VtdHNiaYPvcIF1\WRiZoLvcUBi[3W2ZTDtfYVtd2mmIHzleYtmdWmjIIDheIlmdnRiZYjwdoV{e2mwZzDGUHQ{NUR6M{XZJI12fGG2aX;uJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDseYNq\mW{YYPlJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	MknCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MkGyNFEoRjJ{MkKxNlAyRC:jPh?=
BA/F3	M37uPWZ2dmO2aX;uJIF{e2G7		NVzUU5FnPzJiaILz	NGLWOIZKdmirYnn0bY9vKG:oIGTFUE1NS0tiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjVizszNMi=>	NG\0d5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
K562	Ml3yRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			MUXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVAhRSByLkWg{txONg>?	NVvzU2lVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVI1QDNpPkKzN\|UzPDh\|PD;hQi=>
K562	NFXtUVZEgXSxdH;4bYNqfHliYYPzZZk>		MlnmO\|IhcHK\|	NFPFNpVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBk[WylZXnuMWFOKGG\|c3H5MEBKSzVyIE2gNE42KM7:TT6=	M4DOXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUixOVMzLz5{M{m4NVU{OjxxYU6=
K562	Mlr4R5l1d3SxeHnjbZR6KGG\|c3H5		MXK3NkBpenN?	MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyC3c3nu[{BE[WylZXnuJGFOKGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuOUDPxE1w	M1LZflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{W3OlA{Lz5{NUe1O\|YxOzxxYU6=
K562	NHXXW3BEgXSxdH;4bYNqfHliYYPzZZk>			MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE42KM7:TT6=	MlnvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEm2O\|QoRjJ5MUi5Olc1RC:jPh?=
BA/F3	MlLSR5l1d3SxeHnjbZR6KGG\|c3H5		MmrlO\|IhcHK\|	NV;oR5NIS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgRmNTNUGETDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjVizszNMi=>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
K562	NUi5OlU2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MmC3OFghcHK\|	NFzrVmZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOUDPxE1w	NHG1SWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzNlA4OSd-MkO5N\|IxPzF:L3G+
Sf9	MmrySpVv[3Srb36gZZN{[Xl?			MXfUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO\|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u	M2PKc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562	NFPoWItEgXSxdH;4bYNqfHliYYPzZZk>		MUS3NkBpenN?	M4nyfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPTFizszNMi=>	NHj1U5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkixOFg6OCd-Mk[4NVQ5QTB:L3G+
K562	NIjxVldEgXSxdH;4bYNqfHliYYPzZZk>		Ml3IOFghcHK\|	NE[xcXZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjV\|IN88UU4>	NYXxdpZURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3NFc5PDZpPkK2O\|A4QDR4PD;hQi=>
K562	NEHxfopCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MWS0PEBpenN?	MnX6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkWzJO69VS5?	NWT6ZZQ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5OzhpPkK4OVI2QDN6PD;hQi=>
BA/F3	M3TBemZ2dmO2aX;uJIF{e2G7		MnXzO\|IhcHK\|	MoLETY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIFS4NVZJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD61N\|Uh\|ryPLh?=	M3zXOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
BA/F3	M1LHXGZ2dmO2aX;uJIF{e2G7		MWq3NkBpenN?	MkHVTY5pcWKrdHnvckBw\iCSRFfGVoFteGijIG[1OlFFN0R6NELWJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhVVSVIHHzd4F6NCCJSUWwJF0hOC53Nkeg{txONg>?	NYPlb3J2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
K562	NFfONopEgXSxdH;4bYNqfHliYYPzZZk>		MVy0PEBpenN?	NYn3VppyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53ODFOwG0v	Ml32QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OUWzPFAoRjJzMkm1N\|gxRC:jPh?=
BA/F3	MmHkR5l1d3SxeHnjbZR6KGG\|c3H5		NXPVVmVDPzJiaILz	MkLpR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKEV\|NUnWJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjV7IN88UU4>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
BA/F3	M2fs[2Z2dmO2aX;uJIF{e2G7		NInWZXo4OiCqcoO=	M3HJXGlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwMW0{PTGWIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFAvPjJ3IN88UU4>	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BAF3	Mn;XSpVv[3Srb36gZZN{[Xl?		NWe3RXQ2PzJiaILz	MmPETY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iTUO1OnQhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuOlI2KM7:TT6=	M33ISFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BA/F3	NV7Qc5dzTnWwY4Tpc44h[XO\|YYm=		MWq3NkBpenN?	NHvXOIdKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNE1SOjV{SDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjZ3OTFOwG0v	MnjsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BA/F3	M{LhfWZ2dmO2aX;uJIF{e2G7		NHnrZnI4OiCqcoO=	NIDFRYZKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgXVgzO0RibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlY3QSEQvF2u	NV;ZS2p3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NVLjZ2dTSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMNUB1emGwc3\lZ5Rm\CCvb4Xz[UBDSS:IMzDj[YxteyxiSVO1NEA:KDBwNke4JO69VS5?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
BA/F3	NXi1O4Z[TnWwY4Tpc44h[XO\|YYm=			NEWzNXpKdmirYnn0bY9vKG:oIHj1cYFvKEKFUj3BRmwyKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHL5JGFVWC2mZYDs[ZRqd25iYYPzZZktKEmFNUCgQUAxNjZ5ODFOwG0v	M{XhUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
K562	NU[4NWVjSXCxcITvd4l{KGG\|c3H5		NUjSclB1PDhiaILz	M2\EdWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliYX7u[ZhqdlZiYX7kJJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnegZoF{\WRiZnzve{BkgXSxbXX0dpktKEGFNUCgQUAxNjZ6IN88UU4>	NF\0VI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[yPVg2QSd-Mk[2Nlk5PTl:L3G+
BA/F3	M1zrdWZ2dmO2aX;uJIF{e2G7		MX63NkBpenN?	MV\Jcohq[mm2aX;uJI9nKEurdDDWOVYxTC:YNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwN{CxJO69VS5?	M1vlclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
K562	NXrTVWNIS3m2b4TvfIlkcXS7IHHzd4F6		NXf3WXJ4PzJiaILz	M{j0NGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIZtfW:{ZYPj[Y5k\SCvaXPyc5Bt[XSnIILlZYRmeiCvZYToc4QtKEmFNUCgQUAxNjd\|IN88UU4>	M{XGT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{SxPFU{Lz5{Nke0NVg2OzxxYU6=
BAF3	NUm3bJlOTnWwY4Tpc44h[XO\|YYm=		NV\YOno1PzJiaILz	Mn76TY5pcWKrdHnvckBw\iCDQlygbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwN{Og{txONg>?	NVjGSmh7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5O\|Q{OzhpPkK4PVc1OzN6PD;hQi=>
insect cells	NXKyTFE{TnWwY4Tpc44h[XO\|YYm=		NH3EPWU{OCCvaX7z	MmrtTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJHkzPTOIIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwN{S5OkDPxE1w	NF;3[YQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	NWfpemk1TnWwY4Tpc44h[XO\|YYm=		M{PsXVIhcHK\|	NHfSdYFKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEBifXSxcHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhOiCqcoOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|LDDJR\|UxKD1iMD63OUDPxE1w	NY\KUms1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxPFg2PzlpPkKwNVg5PTd7PD;hQi=>
BAF3	Mn\aSpVv[3Srb36gZZN{[Xl?		NWnvc3BVPzJiaILz	NYLyOFlDUW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCYNUW5SE9XPjV2QTDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gZZN{[XluIFfJOVAhRSByLkiwN{DPxE1w	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3	NFi1XWlHfW6ldHnvckBie3OjeR?=		M4HFWVczKGi{cx?=	MWTJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJHY3PTSDIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD64NFMyKM7:TT6=	MoizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Ba/F3	NXG3fZFwTnWwY4Tpc44h[XO\|YYm=		NEPWO5Q1QCCqcoO=	MlLPTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSC\MkWzTEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK\|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvQDN4IN88UU4>	NVmwclhKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Ba/F3	MUjGeY5kfGmxbjDhd5NigQ>?		M3;zcVQ5KGi{cx?=	MlzWTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCHMkW1T{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK\|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvQDN6IN88UU4>	M3vpZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
BAF3	NGnsN41HfW6ldHnvckBie3OjeR?=		Mn3WO\|IhcHK\|	MYPJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMDDmeZNqd25icILveIVqdiCIM{G3TUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxKD1iMD64OUDPxE1w	NEHtbHo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3	MmXnSpVv[3Srb36gZZN{[Xl?		NGKwUno4OiCqcoO=	M1vxXWlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwMWY{OTeLIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFAvQDV3IN88UU4>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
Ba/F3	MXzGeY5kfGmxbjDhd5NigQ>?		MYm0PEBpenN?	MmnPTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCHMkW1WkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK\|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvQDd2IN88UU4>	NY\vbmVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Sf9	NH[2[4RHfW6ldHnvckBie3OjeR?=			MYnUVH9VWkGQU2DPVnRGWjpiZX\mcJV5KG:oIFjv[YNpe3R\|M{O0NkBqdiCEQ2LQMYV5eHKnc4PpcochW2Z7IHPlcIx{NCCLQ{WwJF0hOC57IN88UU4>	NIW5U4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUG1OVg1OSd-MUWxOVU5PDF:L3G+
CHO	M1f3S2Z2dmO2aX;uJIF{e2G7			M1PFfGlvcGmkaYTpc44hd2ZiY3jpcYVzcWNiUFTHSkBz\WOncITvdkB4cXSqIFPTSk0yWiCleYTvdIxie22rYzDkc41icW5icHjvd5Bpd3K7bHH0bY9vKGmwIFPIU{Bk\WyuczygTWM2OCB;IECuPVYh\|ryPLh?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjF4Nkm1NEc,OTJzNk[5OVA9N2F-
BA/F3	NVnlZ5VCSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M3nmbFczKGi{cx?=	NEHhZ\|JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBHOzV7VjDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMD65OkDPxE1w	NYfKXmQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	M{Txe2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M17FbVQ5KGi{cx?=	NIGyZXFCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBCOzN2bDDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwOU[yJO69VS5?	M4rydFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
K562	NGPuXW1EgXSxdH;4bYNqfHliYYPzZZk>		MkP6NlQhcHK\|	Mmn4R5l1d3SxeHnjbZR6KGGpYXnud5QhcW2jdHnubYIue2Wwc3n0bZZmKGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDFizszNMi=>	M4XuflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMk[xOFY5Lz5\|MEK2NVQ3QDxxYU6=
BA/F3	M2frSGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M{PIOlczKGi{cx?=	M2[1T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCINEi2V{BufXSjboSgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOSEQvF2u	Ml3WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
GIST430	NVHhcIFIS3m2b4TvfIlkcXS7IHHzd4F6		MYG3NkBpenN?	M1TVSWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1R2M{CgZ4VtdHNiaHHyZo9zcW6pIFvJWEBXPjV2QTDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCJSUWwJF0hOS5zIN88UU4>	M2e0bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUmxOFY2Lz5{OEm5NVQ3PTxxYU6=
K562	NXTVbGJWS3m2b4TvfIlkcXS7IHHzd4F6		MnvHOFghcHK\|	NVz4eY5IS3m2b4TvfIlkcXS7IHnuJIRzfWdic3Xud4l1cX[nIHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDFwMTFOwG0v	M3;adFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW1PVgyLz5{OU[1OVk5OTxxYU6=
IR-K562	MmjPR5l1d3SxeHnjbZR6KGG\|c3H5			MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBqdWG2aX7pZkBz\XOrc4ThcpQhcHWvYX6gTXIuUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImsJGlEPTBiPTCxMlEh\|ryPLh?=	M4DOfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mk[0OVA{Lz5{NkK2OFUxOzxxYU6=
K562	MkPZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NIPDOWg1QCCqcoO=	NGXXPIFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEGuNVYh\|ryPLh?=	NIn6W249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKzNVA4QSd-Mk[yN\|ExPzl:L3G+
K562	M3rmd2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M1SxWFQ5KGi{cx?=	NI\mTm1EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGW6cILld5NqdmdiQnPyMWFjdCCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMT6xOkDPxE1w	NWr0emhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0OVE4PzJpPkK2OFUyPzd{PD;hQi=>
BA/F3	NFnENVJHfW6ldHnvckBie3OjeR?=		NVOzPWFCPzJiaILz	MorRTY5pcWKrdHnvckBw\iCNaYSgWlU3OERxREixOmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSBzLkG5NUDPxE1w	NWPz[Fg5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BAF3	MWHGeY5kfGmxbjDhd5NigQ>?		MVi3NkBpenN?	MXPJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJGQ5OT[KIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMT6yOFUh\|ryPLh?=	NITLZ5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
FDC-P1	MmDFSpVv[3Srb36gZZN{[Xl?		Mm\wOFghcHK\|	NUnmNVlRUW6qaXLpeIlwdiCxZjDoeY1idiCITWOg[ZhxemW\|c3XkJIlvKGe{b4f0bEBn[WO2b4Kg[IVx\W6mZX70JI1wfXOnIF\ER{1ROSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGZOWy2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iaX6gdJJme2WwY3WgbJVu[W5iQ2PGNUBi\nSncjC0PEBpenNiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUCgQUAyNjJ5NDFOwG0v	M4SxeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUW2Olg6Lz5{MEG1OlY5QTxxYU6=
BAF3	MWLGeY5kfGmxbjDhd5NigQ>?		M3;obFczKGi{cx?=	MUfJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJG45OjKNIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAyNjJ7IN88UU4>	M3;yVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
BAF3	NGTJXnBHfW6ldHnvckBie3OjeR?=		NXLaT29tPzJiaILz	Mnv4TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhVjh{MlugcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDFwMkmg{txONg>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BA/F3	MoLVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MoTtO\|IhcHK\|	M1XoRWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJHkzPTOIIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzLkS0OEDPxE1w	M3jybFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BAF3	MV;GeY5kfGmxbjDhd5NigQ>?		M2PXNlczKGi{cx?=	MX;Jcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJG45OjKNIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMT60OlYh\|ryPLh?=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BA/F3	M1jtRmZ2dmO2aX;uJIF{e2G7		M2nWdlczKGi{cx?=	MnjFTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVYxKHSxIEW3PEBz\XOrZIXld{khdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSBzLkWyN{DPxE1w	NFfGc\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3	NXHNN3Z5S3m2b4TvfIlkcXS7IHHzd4F6		MXm3NkBpenN?	M1P6eGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCHM{W1S{BufXSjboSgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOS54IN88UU4>	MorSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
BA/F3	MnK1SpVv[3Srb36gZZN{[Xl?		MUC3NkBpenN?	NFfHenJKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNE1JOzZ7UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAyNjZ7IN88UU4>	NH7iT3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
GIST882	MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MWe5OkBpenN?	M1S0SmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNU44KM7:TT6=	MkDvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl2Nkm1OFcoRjF7NE[5OVQ4RC:jPh?=
GIST882	MkmzRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Ml3jPVYhcHK\|	MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHntZZRqdmmkLYP1d4NmeHSrYnzlJIh2dWGwIFfJV3Q5QDJiY3XscJMhcGG{Yn;ybY5oKGNvS1nUJGs3PDKHIH31eIFvfCCjZoTldkA6PiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOS55IN88UU4>	MknwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5MkS2OVMoRjJ7N{K0OlU{RC:jPh?=
BAF3	MWjGeY5kfGmxbjDhd5NigQ>?		M3P6XVczKGi{cx?=	NFLiXWNKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEBnfXOrb36gdJJwfGWrbjDIN\|Y6WCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG\|c3H5MEBIUTVyIE2gNU44QSEQvF2u	NGTCPVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3	MnrkRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M{fyRVczKGi{cx?=	NXLDWplESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEY4KtRYJtKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDFwOEO0JO69VS5?	NXLuS5ZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	NWq0WXZQSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MkjyO\|IhcHK\|	M3izOWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGczPTCHIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzLki2N{DPxE1w	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BA/F3	NHXtUGtHfW6ldHnvckBie3OjeR?=		M3PMRlczKGi{cx?=	NVvjTFFNUW6qaXLpeIlwdiCxZjDCR3IwSUKOIICyNVAuTTJ3NVugcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOS57MzFOwG0v	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BA/F3	NUThfmZPTnWwY4Tpc44h[XO\|YYm=		NYHK[ZpGPzJiaILz	NEj3RZBKdmirYnn0bY9vKG:oIGTFUE1UWkNiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAzNjFizszNMi=>	NUPYR2tuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
NCI-H1703	MUjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MnSxO\|IhcHK\|	M1\jc2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgyPzB\|IHPlcIx{KGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOi5zIN88UU4>	M1zEVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
BAF3	NELp[4FHfW6ldHnvckBie3OjeR?=		MV[3NkBpenN?	M2jYbGlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwJIZ2e2mxbjDwdo91\WmwIF[zNVdNKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT\|gh[XO\|YYmsJGdKPTBiPTCyMlE3KM7:TT6=	NHPDfIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3	M2i2SmZ2dmO2aX;uJIF{e2G7		MmP0O\|IhcHK\|	Ml7CTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCtSlMyP0xibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gNk4yPjlizszNMi=>	NFjF[Yc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BA/F3	NHjwT4tCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NV3qWGxuPzJiaILz	MVvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDIN\|k3WiCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOi5\|N{eg{txONg>?	MlXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
HGC27	NGDh[m9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NFHZbnI6PiCqcoO=	NGnwbI5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR\|I4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTBiPTCyMlQh\|ryPLh?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4OUW0O{c,OTl2Nkm1OFc9N2F-
HGC27	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NYXsPYd5QTZiaILz	NVy4N\|hwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIS2MzPyClZXzsd{Bi\nSncjC5OkBpenNiYomgV3JDKGG\|c3H5MEBKSzVyIE2gNk41KM7:TT6=	M4i3T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{K0OlU{Lz5{OUeyOFY2OzxxYU6=
BAF3	MXXGeY5kfGmxbjDhd5NigQ>?		MY[3NkBpenN?	NVfhc4lkUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCYNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMj60PUDPxE1w	MnXOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BAF3	NYi4b\|FrTnWwY4Tpc44h[XO\|YYm=		NWXnSYNYPzJiaILz	MWjJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBXPjV2QTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOi52OTFOwG0v	MmnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BA/F3	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MXe3NkBpenN?	M{Xl[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGY1QD[VIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB{LkW0O{DPxE1w	NUfiWJlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	NIPleldHfW6ldHnvckBie3OjeR?=		NULONW9uPzJiaILz	MoTITY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIFS4NVYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSB{Lke0PUDPxE1w	M1HHcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
HEK293	MYHGeY5kfGmxbjDhd5NigQ>?		MYexMlUhdWmwcx?=	M2mxW2lvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRULLMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgNU42KG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOi57IN88UU4>	M3;oXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MkSxNFI6Lz5{M{K0NVAzQTxxYU6=
BA/F3	MlLmRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NXXQZmM4PzJiaILz	M37remFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGUzPTWNIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB{Lkm1NUDPxE1w	NFG1S5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
BA/F3	NELFO3NHfW6ldHnvckBie3OjeR?=		MVy3NkBpenN?	MlzLTY5pcWKrdHnvckBw\iCWRVytSGRTOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFMh\|ryPLh?=	NYO1OW9VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
BAF3	MVrGeY5kfGmxbjDhd5NigQ>?		NVzTcWxEPzJiaILz	MXHJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY2PTmGL2[2OVRCKGSxdXLs[UBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMzFOwG0v	MkTJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BAF3	MkKwSpVv[3Srb36gZZN{[Xl?		M{j0blczKGi{cx?=	NEX1fpVKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCCYNUW5SE9XPjV2QTDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFMh\|ryPLh?=	NFr6fWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3	M1LRb2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MmTHO\|IhcHK\|	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDUN\|E2USCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOy5yMEWg{txONg>?	NV7MRmhkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3	NVjjNY9FS3m2b4TvfIlkcXS7IHHzd4F6		MmTDO\|IhcHK\|	NEPRc5NEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRkOxO2whdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDNwMzFOwG0v	NWf1OoZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
MDCK	MmDKSpVv[3Srb36gZZN{[Xl?			MmXnTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy\|IHL5JJBp\W:yaH;yZoll\SCDIHHzd4F6NCCLQ{WwJF0hOy5\|ODFOwG0v	MnHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7M{K5OlAoRjF7OUOyPVYxRC:jPh?=
K562	NXuxOVRTSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NIfsVWo4OiCqcoO=	NVzBdHVmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCzMlQ{KM7:TT6=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6NEewPEc,Ojl4OES3NFg9N2F-
BA/F3	M1\KfWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NIL5e404OiCqcoO=	NF3NTFZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiUUK1NmghdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDNwNjFOwG0v	NX\N[\|VuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	MlHZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mnf5O\|IhcHK\|	NULpfIdHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhWTJ3MligcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEOuO\|Y{KM7:TT6=	MlTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
HGC27	M1vRe2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M{XNZlQ5KGi{cx?=	NYXZT4FGS3m2b4TvfIlkcXS7IHHnZYlve3RiSFfDNlch[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEOuPEDPxE1w	NUnFbmQzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA2QDRpPkK0PVAxPTh2PD;hQi=>
BA/F3	MnWxSpVv[3Srb36gZZN{[Xl?		M2C2PVczKGi{cx?=	MojlTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIG[2OVQhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSB\|Lkm0O{DPxE1w	NUP4VmtXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
MCF7 MX	MVnGeY5kfGmxbjDhd5NigQ>?			MX;Jcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW\|c3XkJIlvKE2FRkegUXgh[2WubIOgZpkhUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OCB;IESuNFch\|ryPLh?=	NX;LV4k5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5N\|I6PjBpPkG5PVMzQTZyPD;hQi=>
BA/F3	NGHJTXRHfW6ldHnvckBie3OjeR?=		M1vXclczKGi{cx?=	M1LuO2lvcGmkaYTpc44hd2ZiVFXMMWJNUyBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFQvOSEQvF2u	NU\NcINJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
K562	Mmr6RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NX\5cG1rPDhiaILz	M{PtcmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgRoNzN0GkbDDwc5NqfGm4ZTDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgcYV1cG:mLDDJR\|UxKD1iND6xNkDPxE1w	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4NEi4Okc,OjV2NkS4PFY9N2F-
K562	MkfZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYm0PEBpenN?	MkDyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2LkGyJO69VS5?	Mnn5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{OUi0PVUoRjJ4Mkm4OFk2RC:jPh?=
HEK293	NILPc4pHfW6ldHnvckBie3OjeR?=		MojvN{BucW6\|	M1fqbWlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMj3t[YRq[XSnZDDBV3AsKHWydHHr[UBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIFnfGW{IEOgcYlveyCkeTDmcJVwemW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTC0MlIh\|ryPLh?=	MnjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEGwNlkoRjJ\|MkSxNFI6RC:jPh?=
A549	NHK1[\|NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWHLcoRnPDhiaILz	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwNU[g{txONg>?	NWPaTnJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5OzhpPkK4OVI2QDN6PD;hQi=>
K562/G	M4K2fGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVPTT3JOPzJiaILz	NUnGO3lXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4Mj;HJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Lk[1JO69VS5?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjhzNEi5NEc,OjZ6MUS4PVA9N2F-
BAF3	MlLlRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		Mly4O\|IhcHK\|	NXvZRXlxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gOE43QDZizszNMi=>	MmfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=		MnHEOFghcHK\|	NHPYTVlEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKEKlcj3BZowhXDNzNVmgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSC[VGSgZZN{[XluIFnDOVAhRSB2Lke5JO69VS5?	NWHKfYNORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFA5ODZpPkKzOlAxQDB4PD;hQi=>
MCF7	M4X1WmZ2dmO2aX;uJIF{e2G7			Ml3nTY5pcWKrdHnvckBw\iCDQlPHNkBqdiCqdX3hckBucXSxeHHueJJwdmVvcnXzbZN1[W62IF3DSlch[2WubIOgZpkhUG:nY3jzeEA{OzN2MjDhd5NigSxiSVO1NEA:KDRwOEm3O\|kh\|ryPLh?=	M{\BSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6Nke4OFk2Lz5zOE[3PFQ6PTxxYU6=
Sf9	MUPGeY5kfGmxbjDhd5NigQ>?			M37YSGJqdmSrbnegZYZncW6rdImgeI8hemWlb33ibY5idnRiZoXscEBt\W6pdHigbJVu[W5iTj30[ZJucW6jbDDHV3QufGGpZ3XkJHN6cy2NRDCoN\|U3KHSxIE[zOUBz\XOrZIXld{kh[3m2b4DsZZNucWNiZH;tZYlvKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBU\jliaX7z[YN1KGOnbHzzJJV{cW6pIIDvcJkhTVliNEqxJIF{KHO3YoP0doF1\SxiS3mgQUA2KM7:TT6=	NVrFU3htRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxN\|I4PTJpPkK5NVMzPzV{PD;hQi=>
insect cells	MYjGeY5kfGmxbjDhd5NigQ>?		Mne4N\|AhdWmwcx?=	MVnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgWFMyPUlibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN\|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hPS5zNUWg{txONg>?	Mn7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
BA/F3	M{fsTmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NV[xO4NVPzJiaILz	NXHGWlV4S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIFeyOVBGKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB3LkKg{txONg>?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
HEL	NIDscFNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NUHQOXNrPzJiaILz	MljhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVAhRSB3LkOg{txONg>?	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
K562	MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NGHHdI41QCCqcoO=	NWW1SYFpSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTC1MlQh\|ryPLh?=	NVzzRmVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1O\|YxOjNpPkKxOVc3ODJ\|PD;hQi=>
KBM5	NYSySW5[S3m2b4TvfIlkcXS7IHHzd4F6		MWW3NkBpenN?	MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRm02KGOnbHzzJIhiemKxcnnu[{BD[3JvQXLsJHQ{OTWLIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS52IN88UU4>	M1TlRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUS5OlY2Lz5{MEG0PVY3PTxxYU6=
BA/F3	M2\EemN6fG:2b4jpZ4l1gSCjc4PhfS=>		NGnrUGc4OiCqcoO=	NHu0Z3REgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRUK1OWshdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDVwNjFOwG0v	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
BAF3	M13ic2Z2dmO2aX;uJIF{e2G7		M1LTXVczKGi{cx?=	MXPJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHQ3PzCLL2[1OVlFKGSxdXLs[UBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iNj62O{DPxE1w	NEC1cYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BAF3	MULGeY5kfGmxbjDhd5NigQ>?		NFXIUpI4OiCqcoO=	MUXJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBVPjdySTDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hPi54NzFOwG0v	NGDMN4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3	NVTMdpU1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MVW3NkBpenN?	M{i4NWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTC2Mlch\|ryPLh?=	MlP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
GIST48B	M3i3V2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MWK3NkBpenN?	MoS4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCJSWPUOFhDKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gOk46QDZizszNMi=>	M{n0XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BaF3	MoXsRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M1T2[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcZVzcW6nIFLhSlMh[2WubIOg[ZhxemW\|c3nu[{B4cWymIIT5dIUhVlCPL1HMT{BjgSCdM1jdeIh6dWmmaX7lJJVxfGGtZTDhd5NigSxiSVO1NEA:KDdwMTFOwG0v	M2D3WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUewOFAxLz5zNkm3NFQxODxxYU6=
MCF7	MlfyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NXLEfoVOPzJiaILz	M{DQTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iNz6xNkDPxE1w	Mk\2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OES3NFgoRjJ7Nki0O\|A5RC:jPh?=
A2780	M1jTR2Z2dmO2aX;uJIF{e2G7			MnHRTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJIFlemmjbYnjbY4uemW\|aYP0ZY51KEF{N{iwJINmdGy\|IHL5JGhw\WOqc4SgN\|M{PDJiYYPzZZktKEmFNUCgQUA4NjJ2NEO2JO69VS5?	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ5OES5OUc,OTh4N{i0PVU9N2F-
A2780/ADR	NH31VXRHfW6ldHnvckBie3OjeR?=			M1S1fGlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4h\XiycnXzd4VlKGmwIFGyO\|gxN0GGUjDj[YxteyCkeTDjZYxk\WmwIFHNJIF{e2G7LDDJR\|UxKD1iNz6yOFQ{PiEQvF2u	NU\ZPY91RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe4PVAxQTRpPkG3PFkxODl2PD;hQi=>
BA/F3	MVfGeY5kfGmxbjDhd5NigQ>?		MXe3NkBpenN?	MULJcohq[mm2aX;uJI9nKFSHTD3ESHIzKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gO{44KM7:TT6=	M{SzWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
HEK293	M2jtNmN6fG:2b4jpZ4l1gSCjc4PhfS=>			MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5MEBESzVyIE2gPE41KM7:TT6=	M4SydlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mk[0OVA{Lz5{NkK2OFUxOzxxYU6=
FDC-P1	NXTicJJCTnWwY4Tpc44h[XO\|YYm=		NHLVRY81QCCqcoO=	M{m3[mlvcGmkaYTpc44hd2ZibX;1d4UhT01vQ2PGMZN1cW23bHH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKG:oIHfyc5d1cCCoYXP0c5Ih\GWyZX7k[Y51KG2xdYPlJGZFSy2SMTDj[YxteyCneIDy[ZN{cW6pIHj1cYFvKE[PUzDh[pRmeiB2ODDodpMh[nlicnXzZZp2emmwIHT5[UBz\WS3Y4Tpc44h[XO\|YYmsJGlEPTBiPTC4MlQ{PyEQvF2u	NHLkWYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1OlY5QSd-MkCxOVY3QDl:L3G+
BA/F3	Mnu0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NWXvVmNIPzJiaILz	MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDFNlU2XiCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hQC54MUWg{txONg>?	NEe0[409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C4PFY1PCd-MkOwPFg3PDR:L3G+
A2780	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		M1WzWFczKGi{cx?=	MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB6Lkmg{txONg>?	M3:5N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7Nki0O\|A5Lz5{OU[4OFcxQDxxYU6=
BESM	MV\BcpRqfHK7cHHuc5NwdWGuIHHzd4F6		M1fjZlg5KGi{cx?=	NV\HeZR{SW62aYTyfZBidm:\|b33hcEBi[3Srdnn0fUBi\2GrboP0JHRzgXCjbn;zc41iKGO{dYrpJIFu[XO2aXfveIV{KGmwZnXjeIVlKGmwIFLFV20h[2WubIOgcYVie3W{ZXSgZYZ1\XJiOEigbJJ{KHCxc4TpcoZm[3Srb36gZpkhUFSVIHHzd4F6NCCHQ{WwJF0hQSEQvF2u	NVjXU2lDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1OFc5OTlpPkKwOVQ4QDF7PD;hQi=>
BaF3	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M4HCRmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcZVzcW6nIFLhSlMh[2WubIOg[ZhxemW\|c3nu[{BPWE1xQVzLJGwzPT[WIH31eIFvfCCkeTDbN2hefGi7bXnkbY5mKHWydHHr[UBie3OjeTygTWM2OCB;IEmuNUDPxE1w	MlXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7N{C0NFAoRjF4OUewOFAxRC:jPh?=
BA/F3	Mn[3R5l1d3SxeHnjbZR6KGG\|c3H5		M1L0flczKGi{cx?=	NGHtcIJEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiWUK1N2YhdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDlwMjFOwG0v	NVrKN2JMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	MYXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NVnOPZhuSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhdW:3c3WgRmEwTjNiY3XscJMhcW5icILld4Vv[2Vib3[gbY51\XKuZYXrbY4hOyxiSVO1NEA:KDlwNEW5JO69VS5?	MnnlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N\|goRjJyOEG3OVM5RC:jPh?=
BA/F3	M130PGN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3\uTlczKGi{cx?=	NXj3cohVS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIF[zNVdXKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB7LkWg{txONg>?	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
Ba/F3	MXTGeY5kfGmxbjDhd5NigQ>?		MlPEOFghcHK\|	M1P6NWlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiVEOxOWkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUA6NjZ2NTFOwG0v	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF\|N{m4NUc,OzBzM{e5PFE9N2F-
BA/F3	MVnGeY5kfGmxbjDhd5NigQ>?		NFPyV3Y4OiCqcoO=	M1TT[2lvcGmkaYTpc44hd2ZiVFXMMWhEUyBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFkvPyEQvF2u	NYHr[m9kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O\|g6PTV\|PD;hQi=>
BA/F3	M2TKfGZ2dmO2aX;uJIF{e2G7		NV3ud5V6PzJiaILz	NIrtTHVKdmirYnn0bY9vKG:oIFvpeEBFQDF4VjDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFkvQTNizszNMi=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
HCT116	MoPlR5l1d3SxeHnjbZR6KGG\|c3H5		MY[3NkBpenN?	MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUCg{txONg>?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
HepG2	NVPadHoxSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MYGyOEB1dyB7NjDodpM>	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy\|IHHmeIVzKDJ2IITvJFk3KGi{czDifUBOXFNiYYPzZZktKEmFNUCgQUAyOCEQvF2u	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl\|MkC3NUc,OjN7M{KwO\|E9N2F-
BA/F3	NX;sdZhvS3m2b4TvfIlkcXS7IHHzd4F6		NFHu[WY4OiCqcoO=	NH\0blZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiSEO5OnIhdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDFzLkGg{txONg>?	NETI[WM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
MCF7	NGTsdVVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NGHPcYE6PiCqcoO=	NXTxcYNoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTBiPTCxNU4{KM7:TT6=	NIn4Nms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUeyOFY2Oyd-Mkm3NlQ3PTN:L3G+
MCF7	NVPTT5l5SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Mnv4PVYhcHK\|	M4m3Z2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR\|UxKD1iMUGuOUDPxE1w	NWmyNJhyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olk2PDdpPkG5OFY6PTR5PD;hQi=>
RKOp21	NXO3V4FXS3m2b4TvfIlkcXS7IHHzd4F6		M{jR[\|czKGi{cx?=	NH:yVoZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTU0:yMkGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNVIh\|ryPLh?=	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
BA/F3	MnnlR5l1d3SxeHnjbZR6KGG\|c3H5		NIe1Woc4OiCqcoO=	NEfCOo5EgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiTEK0PHYhdXW2YX70JIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDF{LkKg{txONg>?	NYTYcHRkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	M{H0T2N6fG:2b4jpZ4l1gSCjc4PhfS=>		NUXybVlFPzJiaILz	NWnUV25KS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIGSzNVVKKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzMj6yJO69VS5?	NYrCT41bRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
BA/F3	MoPaR5l1d3SxeHnjbZR6KGG\|c3H5		NYjqWHV6PzJiaILz	MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKFUj3BRmwhYTJ3M1igcZV1[W62IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFEzNjVizszNMi=>	M13WOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
RKOp21	MUfDfZRwfG:6aXPpeJkh[XO\|YYm=		M3THSFczKGi{cx?=	MmHMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVmtQeDJzIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEGyMlU5QTJizszNMi=>	NXzu[HpQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
K562	NY\RT3lOSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MVKyOEBpenN?	MmXHTY4hfmm2cn:gZY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCxN{DPxE1w	M2fiU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
BA/F3	M4P2fGN6fG:2b4jpZ4l1gSCjc4PhfS=>		MXK3NkBpenN?	Mn;ZR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMUOuOUDPxE1w	M{j1NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
U937	M3;MXWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			M1\q[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgWVk{PyClZXzsd{whUUN3MDC9JFE1KM7:TT6=	NFLkfnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkOzNlQ1OCd-MU[zN\|I1PDB:L3G+
BA/F3	MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M3vVbVQ5KGi{cx?=	MVrHdo94fGhiaX7obYJqfGmxbjDv[kBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhXDNzNVmgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzND61JO69VS5?	M2Dy[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NU[yNlE4Lz5{NkW2NlIyPzxxYU6=
A549	M{nqdmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NVXHSHR7PzJiaILz	NEXmPZhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG1MlUh\|ryPLh?=	M1fycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
K562	MmjORY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MWC0PEBpenN?	NYTQTIdSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBqdWG2aX7pZk1z\XOrc4ThcpQhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVUvPyEQvF2u	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ\|MUC3PUc,OjZ{M{GwO\|k9N2F-
MDA-MB-468	M3HEemN6fG:2b4jpZ4l1gSCjc4PhfS=>		NEPjNJQ4OiCqcoO=	NV;wSWtKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzNT64OFg6KM7:TT6=	MlWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
KG1a	MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		Mm\aO\|IhcHK\|	M{LSO2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1exZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwhe3W{dnn2ZYwh[W[2ZYKgO\|IhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE3NjdizszNMi=>	NITXWpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki1NFAxPCd-Mk[4OVAxODR:L3G+
MDA-MB-468	MlPyR5l1d3SxeHnjbZR6KGG\|c3H5		MmK2O\|IhcHK\|	MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE4KM7:TT6=	NEnuToM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HMC-1.2	NVHofmxoSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiPQz2xMlIh[2WubIOgZ4FzenmrbnegWlU3OEduIFS4NVZXKG23dHHueEBie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDF5IN88UU4>	NGLRPWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwOFQxQSd-MkWwNFQ1ODl:L3G+
BA/F3	NWXJU4x4SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Ml\GO\|IhcHK\|	NEfjUmxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEB[OjV\|SDDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMUeuNFg{KM7:TT6=	MoLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
HUVEC	Mkm2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			M{XvSGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgTHVXTUNiY3XscJMtKEeLNUCgQUAyQC53IN88UU4>	NWfs[XlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|k3PzRpPkKyOFM6Pjd2PD;hQi=>
BA/F3	MoLDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MX[3NkBpenN?	M{LE[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG\|c3H5MEBKSzVyIE2gNVgvPTJizszNMi=>	NXfJb2hGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
HeLa	M{PYOGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NFT5eoQ4OiCqcoO=	MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF6Lk[1JO69VS5?	NEnUU4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
GIST48	MmPiR5l1d3SxeHnjbZR6KGG\|c3H5		MXSzJJRwKDZiZHH5dy=>	NWOxTG57S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVES4JINmdGy\|IHHzd4V{e2WmIHHzJIVn\mWldDDvckBk\WyuII\pZYJqdGm2eTDh[pRmeiB\|IITvJFYh\GG7czDifUBtfWOrZnXyZZNmKGKjc3XkJIx2dWmwZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFE5NjdizszNMi=>	NFr1ZXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS2PVU1Pyd-MUm0Olk2PDd:L3G+
Hec1A	NGixSZREgXSxdH;4bYNqfHliYYPzZZk>		MVW3NkBpenN?	NHzze5hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\WNzQTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxPUDPxE1w	NE\6cWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
U937	MYDDfZRwfG:6aXPpeJkh[XO\|YYm=			NESyRmdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWQTN5IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTygTWM2OCB;IEG5JO69VS5?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
HCT116	MlXuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NFL6So44OiCqcoO=	NFLBWolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFEyPiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNVkvPjZizszNMi=>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6NEewPEc,Ojl4OES3NFg9N2F-
GIST48	M1rofmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NVz4S25{QTZiaILz	NUTaNlBiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBqdWG2aX7pZk1z\XOrc4ThcpQhcHWvYX6gS2lUXDR6IHPlcIx{KGijcnLvdolv\yClLVvJWEBXPTZyRD;EPFIxSSCmb4XicIUhdXW2YX70JIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO\|YYmsJGlEPTBiPTCxPU45KM7:TT6=	NV;Fd3l{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlQ3PTNpPkK5O\|I1PjV\|PD;hQi=>
A549	NHO4eJZEgXSxdH;4bYNqfHliYYPzZZk>		NIX1WHc4OiCqcoO=	M3LHbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUmuPVUzPiEQvF2u	MoHCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CAL27	NH7K[nFEgXSxdH;4bYNqfHliYYPzZZk>		NIPpW204OiCqcoO=	M2XvfWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG5Mlk2OjZizszNMi=>	Ml7tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
Hec1A	NHH2XIxEgXSxdH;4bYNqfHliYYPzZZk>		MXW3NkBpenN?	MoPNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVkOUFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUmuPVUzPiEQvF2u	M2TxeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
32D	M3;NWmN6fG:2b4jpZ4l1gSCjc4PhfS=>			NHL1[2hEgXSxdH;4bYMh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTCzNmQhSmO{LXHicEBv\WejdHn2[UBk\WyuczygTWM2OCB;IEKwJO69VS5?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
GIST48B	NG\IbVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NWP5XHlVPzJiaILz	MW\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDHTXNVPDiEIHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEeLNUCgQUAzOCEQvF2u	NXLlbI9XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3O\|MyPTNpPkKzO\|c{OTV\|PD;hQi=>
BV173	NVXx[2tHSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2Pie\|I1KGi{cx?=	MkfaTY4hfmm2cn:gZY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCEVkG3N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNlAh\|ryPLh?=	MkTQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
BAF3	M2PnXGZ2dmO2aX;uJIF{e2G7		MV23NkBpenN?	M4Dw[mlvcGmkaYTpc44hd2ZiQVLMJHQ{OTWLIH31eIFvfCCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNlAvODNizszNMi=>	NXfPN\|g4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5O\|Q{OzhpPkK4PVc1OzN6PD;hQi=>
293T	M1LzTGN6fG:2b4jpZ4l1gSCjc4PhfS=>			MnLIR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gNlk{XCClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdixiQ1O1NEA:KDJyLkWzJO69VS5?	M4LyflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OEWwNFA1Lz5{Nki1NFAxPDxxYU6=
CAL27	Mkf4R5l1d3SxeHnjbZR6KGG\|c3H5		NVHFTolsPzJiaILz	NV7VUoZnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlIh\|ryPLh?=	NGfPe5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H460	NY\iUFRCS3m2b4TvfIlkcXS7IHHzd4F6		NFnS[YU4OiCqcoO=	Mn;yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NDFOwG0v	NYi3c\|BvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
PC3	MmjhR5l1d3SxeHnjbZR6KGG\|c3H5		NITWSYQ4OiCqcoO=	NET2ZVJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMkSg{txONg>?	NHTabo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HCT15	MVvDfZRwfG:6aXPpeJkh[XO\|YYm=		M4DXUVczKGi{cx?=	MorSR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMkWg{txONg>?	M{nweVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
THP1	M3:5d2N6fG:2b4jpZ4l1gSCjc4PhfS=>			NEThfGxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVUFBzIHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTygTWM2OCB;IEK1JO69VS5?	MkmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NkS1NFMoRjJ4Mk[0OVA{RC:jPh?=
HeLa	M{f5Z2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M{C3c\|czKGi{cx?=	M1vGbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmVGFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMkWuNVE5QSEQvF2u	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
H460	NWTmU3JRS3m2b4TvfIlkcXS7IHHzd4F6		NIjP[5g4OiCqcoO=	MnO0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NT6xNVg6KM7:TT6=	NYPDVYhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
HCT15	MlLPR5l1d3SxeHnjbZR6KGG\|c3H5		M2mzXFczKGi{cx?=	Ml;yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMkWuNVE5QSEQvF2u	MmnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
PC3	MnnjR5l1d3SxeHnjbZR6KGG\|c3H5		NYrPSZhvPzJiaILz	Mlq0R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ3LkGxPFkh\|ryPLh?=	MlTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
Saos2	MWnDfZRwfG:6aXPpeJkh[XO\|YYm=		MmDXO\|IhcHK\|	NEXaZ4pEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBU[W:\|MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOU4yOTh7IN88UU4>	NWjUNZA4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
HEK293	M2Xq[GZ2dmO2aX;uJIF{e2G7		NUW1e2h[OyCvaX7z	NES4PIxKdmirYnn0bY9vKG:oIHj1cYFvKE:FVEOtcYVlcWG2ZXSgRXNRMyC3cIThb4Uh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{Bi\nSncjCzJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG\|c3H5MEBKSzVyIE2gNlUvPSEQvF2u	NVryOnljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
Saos2	M4i0TWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NY\Nb29rPzJiaILz	MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTZY9{OiClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NjFOwG0v	NIq0VpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
MCF7	Ml3JR5l1d3SxeHnjbZR6KGG\|c3H5		M1XB[VczKGi{cx?=	NWjscYQ6S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUOINzDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCzNEDPxE1w	M1G2dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
A431	NIPBOIVEgXSxdH;4bYNqfHliYYPzZZk>		MXu3NkBpenN?	Ml;KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB\|MTFOwG0v	NELkdVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H69	NV;ZWpprS3m2b4TvfIlkcXS7IHHzd4F6		MXW3NkBpenN?	NI[y[oVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJPjliY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iM{GuOlIzQCEQvF2u	NX;aWHA6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
MCF7	MkKwR5l1d3SxeHnjbZR6KGG\|c3H5		NUm4bYJUPzJiaILz	NGnNfVFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOxMlYzOjhizszNMi=>	NWPLVoZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
A431	M2DLNWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MVi3NkBpenN?	M1G2XWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iM{GuOlIzQCEQvF2u	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
H69	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=		M3Pwe\|czKGi{cx?=	NX3Wb5pYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDZ7IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyJO69VS5?	NWjEU2NwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
BESM	MWDDfZRwfG:6aXPpeJkh[XO\|YYm=		M1jjZlg5KGi{cx?=	NWLKbXRyS3m2b4TvfIlkcXS7IHHnZYlve3RiQlXTUUBk\WyuczDh[pRmeiB6ODDodpMh[nliSGTTJIF{e2G7LDDFR\|UxKD1iM{Kg{txONg>?	M2nDUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNUS3PFE6Lz5{MEW0O\|gyQTxxYU6=
HCT116	M1rsWmFvfGmlYX7j[ZIh[XO\|YYm=			M{WweGFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUCgQUA{PC52IN88UU4>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjNzMkSzOEc,OjZ\|MUK0N\|Q9N2F-
CCRF-CEM	NHrUVVBEgXSxdH;4bYNqfHliYYPzZZk>		MVW3NkBpenN?	NVrRR2g1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0OURj3DSW0h[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzZizszNMi=>	MmTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
MDA-MB-231	M{HHPGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NY\Mb49nPzJiaILz	MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM4KM7:TT6=	MmDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CCRF-CEM/VCR1000	NI\qS3lEgXSxdH;4bYNqfHliYYPzZZk>		MkPLO\|IhcHK\|	NX64c\|FCS3m2b4TvfIlkcXS7IHHnZYlve3RidnnuZ5Jqe3SrbnWtdoV{cXO2YX70JIh2dWGwIFPDVmYuS0WPL2\DVlExODBiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iM{eg{txONg>?	MmnvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
WM266.4	NFz1cHlEgXSxdH;4bYNqfHliYYPzZZk>		MWq3NkBpenN?	MnX1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW20zPjZwNDDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCzO{DPxE1w	M{[3WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
U87MG	NF\pfmFEgXSxdH;4bYNqfHliYYPzZZk>		MWK3NkBpenN?	M4KxXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHU5P02JIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO4JO69VS5?	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
SKBR3	MkD4R5l1d3SxeHnjbZR6KGG\|c3H5		MVi3NkBpenN?	MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB\|OTFOwG0v	M1[5dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
MDA-MB-231	M1HROmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NHKwXGI4OiCqcoO=	NEewUZdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN7LkixNFch\|ryPLh?=	NUOxUGtnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
SKBR3	NH3uSI5EgXSxdH;4bYNqfHliYYPzZZk>		NYHlTpFOPzJiaILz	NV;zTmZFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|kvQDFyNzFOwG0v	NYDOcG1VRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
AsPC1	NFfPVHhEgXSxdH;4bYNqfHliYYPzZZk>		NGjGToE4OiCqcoO=	MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBd3BEOSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB\|OT64NVA4KM7:TT6=	Ml7HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CCRF-CEM/VCR1000	MUfDfZRwfG:6aXPpeJkh[XO\|YYm=		MmDvO\|IhcHK\|	M{DFfGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnPybZN1cW6nLYLld4l{fGGwdDDoeY1idiCFQ2LGMWNGVS:YQ2KxNFAxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN7LkixNFch\|ryPLh?=	MmrnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CCRF-CEM	M{Hse2N6fG:2b4jpZ4l1gSCjc4PhfS=>		Mor1O\|IhcHK\|	M4Trb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNEWkZvQ1XNJINmdGy\|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM6NjhzMEeg{txONg>?	NUPPOI9IRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
U87MG	NE\SeIZEgXSxdH;4bYNqfHliYYPzZZk>		M{nxbFczKGi{cx?=	NYP1WGRiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXTh5TVegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|kvQDFyNzFOwG0v	M3vReVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
WM266.4	NYWxdYhuS3m2b4TvfIlkcXS7IHHzd4F6		Ml\hO\|IhcHK\|	MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDXUVI3Pi52IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO5MlgyODdizszNMi=>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
AsPC1	NXHobmpJS3m2b4TvfIlkcXS7IHHzd4F6		Mn;zO\|IhcHK\|	MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBd3BEOSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NDFOwG0v	M2\lZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
CCRF-CEM	NXnJNZE6SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NFexeG4zPCCqcoO=	MULJckB3cXS{bzDhcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEOFUl[tR2VOKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1PSEQvF2u	Mk\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
A2780	NF3NRm5EgXSxdH;4bYNqfHliYYPzZZk>		NXn2S3NIPzJiaILz	M3Lhb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES4JO69VS5?	M1Wxe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
Vero	NFy2W5dCdnSrdnnyZYwh[XO\|YYm=		MYKzJIRigXN?	MYLBcpRqfmm{YXygZYN1cX[rdImgZYdicW6\|dDDE[Y5ofWVidnnyeZMhcW6oZXP0[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgWoVzdyClZXzsd{Bi\G2rbnnzeIVz\WRiYnXmc5JmKH[rcnHsJINp[WyuZX7n[UBi\nSncjCzJIRigXNiYomgeolz[WxicHzhdZVmKGG\|c3H5	M2\2eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{[wOlc3Lz5zN{O2NFY4PjxxYU6=
Ba/F3	MYDGeY5kfGmxbjDhd5NigQ>?	NX3UPWJEOSC3TR?=	MlfTNlQhcHK\|	MkD5TY5pcWKrdHnvckBw\iBzND2zMVN{cWevYTDpckBpfW2jbjDCZU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEY4KtRYJtKGOxboP0dpVkfCCjc4Pld5Nm\CCjczDy[Yxm[XOnIH;mJIZ2dGxvbHXu[5RpKGNvQXLsJIZzd21iY4n0c5Bt[XOvaXOgZ49ueGyneDD3bZRpKDF2LUOtN5Nq\22jIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc5Bz\WOrcHn0ZZRqd25xaX3teY5w[myxdDD0[YNpdmmzdXW=	MoTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NkK1O\|YoRjJzOU[yOVc3RC:jPh?=
Ba/F3	NXzrUoJnTnWwY4Tpc44h[XO\|YYm=	NHnN[28yKHWP	M{L3OlI1KGi{cx?=	MVLJcohq[mm2aX;uJI9nKDF2LUOtN5Nq\22jIHnuJIh2dWGwIFLhM2Y{KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKlcj3BZowh[2:wc4TyeYN1KGG\|c3Xzd4VlKGG\|IH71Z4xm[XJiaX3wc5J1KG:oIH\1cIwudGWwZ4ToJIMuSWKuIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc5Bz\WOrcHn0ZZRqd25xaX3teY5w[myxdDD0[YNpdmmzdXW=	NVracldSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlI2PzZpPkKxPVYzPTd4PD;hQi=>
Neuro2a	M4XpcGZ2dmO2aX;uJIF{e2G7	MVKxJJVO		MliwTY5pcWKrdHnvckBw\iCGUkK0JIlvKESqY4K3MYRm\mmlaXXueEBud3W\|ZTDO[ZVzdzKjIHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJFcuTEiFIHzleoVteyCjdDCxJJVOKGK7IFzDMW1UN0eFLV3TJIFv[Wy7c3nz	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OU[1O{c,OjZ5OEm2OVc9N2F-
K562	MV;GeY5kfGmxbjDhd5NigQ>?	MW[xNFAhfU1?	NWn2b5VQQCCqcoO=	MojOTY5pcWKrdHnvckBw\iCEQ2KtRWJNKHOrZ37hcIlv\yCyYYToe4F6KGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgd5VxeHKnc4Ppc44hd2ZiU2TBWFUheGixc4Doc5J6dGG2aX;uJIF1KDFyMDD1UUBi\nSncjC4JIhzeyCrbjDwdoV{\W6lZTDv[kBO\UKVIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	NYXvcWl5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OlY3OzVpPkK3OlY3PjN3PD;hQi=>
K562	NV\lNplQTnWwY4Tpc44h[XO\|YYm=	MXWxNFAhfU1?	MoPtPEBpenN?	NF3JR4lKdmirYnn0bY9vKG:oIFLDVk1CSkxiaX6gd4lodmGuaX7nJJBifGi5YYmgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDDdotNKHCqb4PwbI9zgWyjdHnvckBifCBzMECgeW0h[W[2ZYKgPEBpenNiaX6gdJJme2WwY3Wgc4YhVWWEUzDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	NWPuTHBoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OlY3OzVpPkK3OlY3PjN3PD;hQi=>
K562	Mn\CSpVv[3Srb36gZZN{[Xl?	NXjxUHpnOTByIIXN	MWi4JIhzew>?	MVrJcohq[mm2aX;uJI9nKEKFUj3BRmwheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[XRiMUCwJJVOKGGodHXyJFghcHK\|IHnuJJBz\XOnbnPlJI9nKE2nQmOgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|	M2D3c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5Nk[2OlM2Lz5{N{[2OlY{PTxxYU6=
K562	NYDDXWFtTnWwY4Tpc44h[XO\|YYm=	MWixNEB2VQ>?	M325cVEhcHJ?	MWXJcohq[mm2aX;uJI9nKHS7cn;zbY5mKHCqb4PwbI9zgWyjdHnvckBw\iCycn;0[YlvKHerdHigcY9t\WO3bHHyJJdmcWeqdDDi[ZR4\WWwIESwJIFv\CB4MDDrSIEhcW5iaIXtZY4hUzV4MjDj[YxteyCjdDCxNEB2VSCjZoTldkAyKGi{IHL5JIludXWwb3Lsc5Qh[W6jbInzbZM>	NGPLUG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[4NVk5Pid-MkS2PFE6QDZ:L3G+
K562	NVrjfox1TnWwY4Tpc44h[XO\|YYm=	NWDPT45lOTBidV2=	Mm\UNUBpeg>?	M2fRTWlvcGmkaYTpc44hd2ZiQnPyM2FjdCCtaX7hd4UhfHm{b4PpcoUheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNUBpeiCkeTDpcY12dm:kbH;0JIFv[Wy7c3nz	NVXtfGRWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFE6QDZpPkK0OlgyQTh4PD;hQi=>
K562	NIL4UlRHfW6ldHnvckBie3OjeR?=	M2fFbFExKHWP	MVmxJIhz	NWrYfHlbUW6qaXLpeIlwdiCxZjDBZowhc2mwYYPlJJR6em:\|aX7lJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDLOVYzKGOnbHzzJIF1KDFyIIXNJIFnfGW{IEGgbJIh[nliaX3teY5w[myxdDDhcoFtgXOrcx?=	MljMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
DAOY	MoKzdWhVWyCjc4PhfS=>			NWPve4l4eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>?	NXGxeXZCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>
NCI-H1703	MofoSpVv[3Srb36gZZN{[Xl?	MoqwNUB2VQ>?	Mm\NNkBpenN?	MWnJcohq[mm2aX;uJI9nKFCGR1[tbY5lfWOnZDDQSGdHWmGucHjhJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUe1OEBz\XOrZIXlJIlvKGi3bXHuJG5EUS2KMUewN{Bk\WyuczDheEAyKHWPIHHmeIVzKDJiaILzJIlvKHC{ZYPlcoNmKG:oIGDES2YuSUFiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	Ml;rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
NCI-H1703	MnrySpVv[3Srb36gZZN{[Xl?	MV2xJJVO	NV3aeJhoOiCqcoO=	MmnYTY5pcWKrdHnvckBw\iCSRFfGMYlv\HWlZXSgVGRITlKjbIDoZUBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGmxNFE5KHKnc3nkeYUhcW5iaIXtZY4hVkOLLVixO\|A{KGOnbHzzJIF1KDFidV2gZYZ1\XJiMjDodpMhcW5icILld4Vv[2Vib3[gVGRITi2DQTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	MnTNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
NCI-H1703	MlnRSpVv[3Srb36gZZN{[Xl?	NIHxXVcyKHWP	MoPtNkBpenN?	MXXJcohq[mm2aX;uJI9nKFCGR1[tbY5lfWOnZDDQSGdHWmGucHjhJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUi0PUBz\XOrZIXlJIlvKGi3bXHuJG5EUS2KMUewN{Bk\WyuczDheEAyKHWPIHHmeIVzKDJiaILzJIlvKHC{ZYPlcoNmKG:oIGDES2YuSUFiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{	M3TLZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
EOL-1	MnPZSpVv[3Srb36gZZN{[Xl?	MmTaNUB2VQ>?	NV;YeZN{OiCqcoO=	Mkj2TY5pcWKrdHnvckBw\iCSRFfGVoFteGijIHnuJIh2dWGwIFXPUE0yKGOnbHzzJIF{e2W\|c3XkJIF{KGSnY4LlZZNmKGmwIGPURXQ2KHCqb4PwbI9zgWyjdHnvckBifCC\Nkm0JJJme2mmdXWgZZQhOSC3TTDh[pRmeiB{IHjyd{BqdiCycnXz[Y5k\SCxZjDQSGdHNUGDIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
EOL-1	MojWSpVv[3Srb36gZZN{[Xl?	MV:xJJVO	MlT2NkBpenN?	NEHvNHlKdmirYnn0bY9vKG:oIGDES2ZT[WyyaHGgbY4hcHWvYX6gSW9NNTFiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckBifCCWMkCyM3kzODRicnXzbYR2\XNiYYSgNUB2VSCjZoTldkAzKGi{czDpckBxemW\|ZX7j[UBw\iCSRFfGMWFCKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
K562	MUTGeY5kfGmxbjDhd5NigQ>?	NX;KW5VzOSC3TR?=		MnLwTY5pcWKrdHnvckBw\iCEQ2KtRWJNKGmwIHntZZRqdmmkLYPlcpNqfGm4ZTDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEO{S1ygdIhwe3Cqb4L5cIF1cW:wIHH0JFEhfU1iYomgbY1ufW6xIHLsc5Qh[W6jbInzbZM>	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ4MUS2PEc,OzB{NkG0Olg9N2F-
BA/F3	MYDBcpRqfHWvb4KgZZN{[Xl?	Ml\DOVAhdWdxa3e=	NYPZT3FiOTRiZHH5dy=>	M4O1ZWFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKFUj3BRmwh[Wyub3fyZYZ1\WRiaX6gV2NKTCCvb4Xz[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHfyc5d1cCCjdDC1NEBu\y:tZzygdI8heWRiZn;yJFE1KGSjeYO=	MluyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
Ba/F3	NIXv[GxHfW6ldHnvckBie3OjeR?=		MUWxJIhz	NWPhXYlyUW6qaXLpeIlwdiCxZjDCZ5IuSWKuIGSzNVVKKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKjL1[zJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCyaH;zdIhwenmuYYTl[EBUXEGWNTDs[ZZmdCCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	M{K1fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCwPFA3Lz5{M{[wNFgxPjxxYU6=
Ba/F3	NXPZdIJTTnWwY4Tpc44h[XO\|YYm=		NXXoZ3hEOSCqch?=	MlPKTY5pcWKrdHnvckBw\iCEY4KtRYJtKFR\|MUXJJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDv[kBxcG:\|cHjvdplt[XSnZDDDdotNKGyndnXsJIFnfGW{IEGgbJIh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	M{nEelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkCwPFA3Lz5{M{[wNFgxPjxxYU6=
Ba/F3	MWfGeY5kfGmxbjDhd5NigQ>?		M1KzS\|EhcHJ?	NYHpcWs6UW6qaXLpeIlwdiCxZjDCZ5IuSWKuIGSzNVVKKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJBpd3OyaH;yfYxifGmxbjD0doFve2[nY4Tl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>?	NGHpN449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
K562	NUTPSIJ[TnWwY4Tpc44h[XO\|YYm=		M332[FYhcHK\|	M2fPbWlvcGmkaYTpc44hd2ZiQlPSMWFDVC2vZXTpZZRm\CCVVFHUOUBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC2JIhzeyCkeTDwbI9{eGixLX\sc5ch[3m2b33leJJ6	M3PVO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUS4OVg1Lz5{MkG0PFU5PDxxYU6=
K562	NVjZVpg2TnWwY4Tpc44h[XO\|YYm=	M4TUXFQxKHWP	MoHCOkBpenN?	MUnJcohq[mm2aX;uJI9nKEKFUj3BRmwudWWmaXH0[YQhTVKNMTDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDheEA1OCC3TTDh[pRmeiB4IHjyd{BjgSCyaH;zdIhwNW[ub4egZ5l1d22ndIL5	M{ixcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUS4OVg1Lz5{MkG0PFU5PDxxYU6=
K562	MUPGeY5kfGmxbjDhd5NigQ>?	MUG0NEB2VQ>?	NF7PXms3KGi{cx?=	MX\Jcohq[mm2aX;uJI9nKEKFUj3BRmwudWWmaXH0[YQhTVKNMjDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDheEA1OCC3TTDh[pRmeiB4IHjyd{BjgSCyaH;zdIhwNW[ub4egZ5l1d22ndIL5	NXrt[YRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOFg2QDRpPkKyNVQ5PTh2PD;hQi=>
GISTT1	M2fpd2Z2dmO2aX;uJIF{e2G7	M2fzRVEhfU1?	NVXnTY83OiCqcoO=	MUnJcohq[mm2aX;uJI9nKGNvS1nUJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUexPUBqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?=	MlTiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1	MUDGeY5kfGmxbjDhd5NigQ>?	MVWxJJVO	NU\xdGRiOiCqcoO=	NHjscllKdmirYnn0bY9vKG:oIHOtT2lVKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVgzOyCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	NHfFPIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GISTT1	NFfhfndHfW6ldHnvckBie3OjeR?=	NYrNb21COSC3TR?=	NYXGbph3OiCqcoO=	MYjJcohq[mm2aX;uJI9nKGNvS1nUJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUewN{BqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?=	NGHrXY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882	MWXGeY5kfGmxbjDhd5NigQ>?	M1HlblEhfU1?	M33lcVIhcHK\|	MmnKTY5pcWKrdHnvckBw\iClLVvJWEBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGm4NlMhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	NF[3XWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882	MUTGeY5kfGmxbjDhd5NigQ>?	M1y3TFEhfU1?	M4DzXlIhcHK\|	MYXJcohq[mm2aX;uJI9nKGNvS1nUJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUewN{BqdiCqdX3hckBIUVOWOEiyJINmdGy\|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne=	MkjGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GIST882	Mki0SpVv[3Srb36gZZN{[Xl?	NE\pRZQyKHWP	Mo\1NkBpenN?	Ml33TY5pcWKrdHnvckBw\iClLVvJWEBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGm3NVkhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	Mnj1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1	M3nscGZ2dmO2aX;uJIF{e2G7	MY[xJJVO	NEfUO3MzKGi{cx?=	NVTtbWxMUW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC\|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEGNVDDwbI9{eGixconsZZRqd25iYYSgV\|Q4OyCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	Mmm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1	M1nLfmZ2dmO2aX;uJIF{e2G7	M2XsZlEhfU1?	NFX5S\|QzKGi{cx?=	MoLLTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJHN1[XR\|L{WgdIhwe3Cqb4L5cIF1cW:wIHH0JHk4ODVxWU[5OEBqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?=	NEPkUGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GISTT1	NEOwR4dHfW6ldHnvckBie3OjeR?=	NVfoRoJ7OSC3TR?=	NXz4Z\|J5OiCqcoO=	MVXJcohq[mm2aX;uJI9nKGNvS1nUJI1m\GmjdHXkJJNq\26jbHnu[{Bx[XSqd3H5d{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gSXJMOS9{IIDoc5NxcG:{eXzheIlwdiCjdDDUNlAzN1l{MESgbY4hcHWvYX6gS2lUXFRzIHPlcIx{KGG2IEGgeW0hdWWjc4Xy[YQh[W[2ZYKgNkBpenNiYomgbY1ufW6xYnzveJRqdmd?	M17iVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	MYjGeY5kfGmxbjDhd5NigQ>?	NUjXTYhzOSC3TR?=	MYqyJIhzew>?	MknZTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJHM3KHCqb4PwbI9zgWyjdHnvckBifCCVMkO1M\|I{PiCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	M4jsSmZ2dmO2aX;uJIF{e2G7	MmHoNUB2VQ>?	MYOyJIhzew>?	NF3YfmlKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hWzZicHjvd5Bpd3K7bHH0bY9vKGG2IGOyN\|UwOjN4IHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XRiMTD1UUBu\WG\|dYLl[EBi\nSncjCyJIhzeyCkeTDpcY12dm:kbH;0eIlv\w>?	M4DVdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	NVrxTWZtS2WubDDjfYNt\SCjc4PhfS=>	NIT5VogyKHWP	M3WyTFQ5KGi{cx?=	NIfTR3lE\WyuIHP5Z4xmKGG{cnXzeEBqdiCqdX3hckBIUVOWOEiyJINmdGy\|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDHNE9IOSCyaHHz[UBifCBzIIXNJIFnfGW{IES4JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnL2LOZZNmKHO2YXnubY5oKGKjc3XkJIZtd3diY4n0c41mfHK7	M{XMeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
K562	NXT4RWs4SXCxcITvd4l{KGG\|c3H5	M4ja[lEhfU1?		MoHETY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINt\WG4YXflJI9nKFCDUmCgZZQhOSC3TTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
K562	NHriZW1CeG:ydH;zbZMh[XO\|YYm=	Mo\zNUB2VQ>?		NInsRo9KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iY3zlZZZm\CClYYPwZZNmNTNibHX2[Ywh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
K562	MkfUR4VtdCCleXPs[UBie3OjeR?=	MkW3NUB2VQ>?	MkL6NlQhcHK\|	M1vzXmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGs2PjJiY3XscJMh[XO\|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUwWk6jc3Wgd5RicW6rbnegZoF{\WRiZnzve{BkgXSxbXX0dpk>	M{\SNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	MkfGSpVv[3Srb36gZZN{[Xl?	NVfXZlFqOSC3TR?=	NWHMOXZSOiCqcoO=	M{\LOmlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBUPkticHjvd5Bpd3K7bHH0bY9vKGG2IGSzPFkhcW5iaIXtZY4hT0mVVGSxJINmdGy\|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
KU812	M{T5cWFxd3C2b4Ppd{Bie3OjeR?=	NHmyTGcyKHWP		NUXmdpFSUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDQRXJRKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz	NX62OHF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	M2\nVWZ2dmO2aX;uJIF{e2G7	MXuxJJVO	NYLzcGxCOiCqcoO=	M1THcGlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBUfGG2Mz:1JJBpd3OyaH;yfYxifGmxbjDheEB[PzB3L2m2PVQhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n	NU\hXXF4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
KU812	NWjrVYttSXCxcITvd4l{KGG\|c3H5	M{nBdVEhfU1?		NWXONnNpUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDjcIVifmWmIHPhd5Bie2VvMzDs[ZZmdCCjdDCxJJVOKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	MnjQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GIST882	MXrGeY5kfGmxbjDhd5NigQ>?	NGHR[lcyKHWP	NHPSV5IzKGi{cx?=	MkLETY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO\|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVTUzFxMjDwbI9{eGixconsZZRqd25iYYSgWFIxOi:\MkC0JIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?=	NEHEWpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882	M2XhXGZ2dmO2aX;uJIF{e2G7	NWnKSoU6OSC3TR?=	M1\0elIhcHK\|	NEL1NFNKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hWz[NIIDoc5NxcG:{eXzheIlwdiCjdDDUN\|g6KGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	NXvPSXZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
KU812	NIXhdY1E\WyuIHP5Z4xmKGG\|c3H5	NGPDc\|cyKHWP	NWPobmI3OTJiaILz	M2f0bmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGtWQDF{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHHjZ5VufWyjdHnvckBifCCJMD;HNUBxcGG\|ZTDheEAyKHWPIHHmeIVzKDF{IHjyd{BjgSCycn;wbYRqfW1iaX;kbYRmN1KQYYPlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
MEG01	MWXBdI9xfG:\|aYOgZZN{[Xl?	NWDoTHdLOSC3TR?=		MXHJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKE2HR{CxJINmdGy\|IHHzd4V{e2WmIHHzJINt\WG4YXflJI9nKFCDUmCgZZQhOSC3TTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN?	M3j2T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1	MnHxRZBweHSxc3nzJIF{e2G7	NE\uOmUyKHWP		NV;2SoZxUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO\|ZYPz[YQh[XNiY3zlZZZi\2Vib3[gVGFTWCCjdDCxJJVOKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=>	MoH1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GIST882	M2W5[GFxd3C2b4Ppd{Bie3OjeR?=	NULBSWM3OSC3TR?=		MV;JcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO\|ZXSgZZMh[2ynYY\h[4Uhd2ZiUFHSVEBifCBzIIXNJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882	NX7hN45xSXCxcITvd4l{KGG\|c3H5	MoHqNUB2VQ>?		NHzFeZBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m\|IHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnLUOgcIV3\WxiYYSgNUB2VSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	NIm0Umo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
MEG01	M3fXcmNmdGxiY4njcIUh[XO\|YYm=	NWnzeVNqOSC3TR?=	NVvZO\|RzOjRiaILz	NXrzeY9iS2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hVUWJMEGgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFewM2cyKHCqYYPlJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVxUl7hd4Uhe3SjaX7pcoch[mG\|ZXSg[oxwfyCleYTvcYV1enl?	NHvTUWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GISTT1	M1T6dmNmdGxiY4njcIUh[XO\|YYm=	NHfVVIIyKHWP	MnfGNlQhcHK\|	M{GxXmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGdKW1SWMTDj[YxteyCjc4Pld5Nm\CCjczDhZ4N2dXWuYYTpc44h[XRiR{CvS\|EheGijc3WgZZQhOSC3TTDh[pRmeiB{NDDodpMh[nlicILvdIllcXWvIHnv[Ill\S:UTnHz[UB{fGGrbnnu[{Bj[XOnZDDmcI94KGO7dH;t[ZRzgQ>?	NEDRPW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
MEG01	NEXQ[mtCeG:ydH;zbZMh[XO\|YYm=	MkLsNUB2VQ>?		M4HHeGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iTVXHNFEh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iY3zlZZZm\CClYYPwZZNmNTNibHX2[Ywh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYO=	MmX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1	NEXSPXFCeG:ydH;zbZMh[XO\|YYm=	NHXB[nkyKHWP		NV[xZW51UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZ4xm[X[nZDDjZZNx[XOnLUOgcIV3\WxiYYSgNUB2VSCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM>	M1i1cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	MV7GeY5kfGmxbjDhd5NigQ>?	NIHVPGEyKHWP	M3fnU\|IhcHK\|	NH;teJlKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDTOFc{KGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=>	MkThQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
LAMA-84	MojlS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NGnaV2FKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMEezNFQh\|ryPLh?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EM-2	M2XY[mdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MXrJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFg5QCEQvF2u	MmrZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
MEG-01	NELjPY1Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NYr6e2tRUW6qaXLpeIlwdiCxZjDoeY1idiCPRVetNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMEi5NlEh\|ryPLh?=	NF;V[I89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
BV-173	MV\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MoTwTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvOTh5NDFOwG0v	M3;GWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
K-562	MkXjS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MnjHTY5pcWKrdHnvckBw\iCqdX3hckBMNTV4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNE4zOjR\|MjFOwG0v	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
CGTH-W-1	M13w[2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NFLkO5VKdmirYnn0bY9vKG:oIHj1cYFvKEOJVFitW{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSByLkO4N\|c1KM7:TT6=	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ST486	M3[2PGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NYPhdpdxUW6qaXLpeIlwdiCxZjDoeY1idiCVVES4OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOC54OEW0JO69VS5?	NFf2PGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NCI-H1436	NGnM[IpIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NHftNIRKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVQ{PiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMD65O\|gxOSEQvF2u	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NOS-1	M3PpdGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NGLH[XFKdmirYnn0bY9vKG:oIHj1cYFvKE6RUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyNjZ3M{izJO69VS5?	NYDMflBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
A498	M3Huc2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NUPQWJVzUW6qaXLpeIlwdiCxZjDoeY1idiCDNEm4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzNjV5MkKzJO69VS5?	NUnFclB2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
BE-13	NYHnWHZsT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MUDJcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF\|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyMlYzOTB4IN88UU4>	NGjIWoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SUP-T1	M17JbGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MVjJcohq[mm2aX;uJI9nKGi3bXHuJHNWWC2WMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN{45OjlyNzFOwG0v	MkPxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NCI-H1770	M13zWmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NFHvcGFKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc4OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iNT61O\|I3OiEQvF2u	MoDEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
IMR-5	MljQS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NET3Z\|BKdmirYnn0bY9vKG:oIHj1cYFvKEmPUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA3NjJ{MUS3JO69VS5?	NWDuXGFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LB2241-RCC	NVzS[lZbT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M1zrWWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iOD6wO\|M5PCEQvF2u	M{m1[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TGBC24TKB	M1Hx[Wdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NEjFVGJKdmirYnn0bY9vKG:oIHj1cYFvKFSJQlOyOHRMSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iOD6zOFA2OiEQvF2u	NXXhXnVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SCC-15	MknwS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNESy1zNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNVAvPzd6ODFOwG0v	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
BB49-HNC	MVTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NFLNSmFKdmirYnn0bY9vKG:oIHj1cYFvKEKENEmtTG5EKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzND6zN\|M2KM7:TT6=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ES7	M2OxdGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MmjVTY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG0Mlc{PzlizszNMi=>	NGHlc2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB2518-MEL	MmXsS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NVfweYRiUW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxOk43ODl2IN88UU4>	M{TtRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NCI-H510A	M4DZN2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MmK2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkK0OFIh\|ryPLh?=	MlnvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-441-T	NGXVWIxIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NI\YT3lKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUS0NU1VKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzNz6yPFg3KM7:TT6=	NV2zV5RNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
HH	MkfMS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M{KzeWlvcGmkaYTpc44hd2ZiaIXtZY4hUEhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG3MlM6QTlizszNMi=>	NFHwZYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LC4-1	NYjLSWNOT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MVPJcohq[mm2aX;uJI9nKGi3bXHuJGxEPC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxPE4xPjV{IN88UU4>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
KARPAS-45	M4jYXGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MlHUTY5pcWKrdHnvckBw\iCqdX3hckBMSVKSQWOtOFUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF6LkG4OFgh\|ryPLh?=	MonRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LB1047-RCC	NGHpNHdIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MWDJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF6LkS0OVIh\|ryPLh?=	MmXDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NKM-1	NY\tO45FT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M2n1fGlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE6NjN3NUKg{txONg>?	NFfGd5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SCLC-21H	MXnHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NYPH[ZZQUW6qaXLpeIlwdiCxZjDoeY1idiCVQ1zDMVIyUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMkCuNVI1PiEQvF2u	NY\mRoRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
RS4-11	M17vWGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MXzJcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlAvOzNyODFOwG0v	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ALL-PO	MkPTS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MWXJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlAvQDF2OTFOwG0v	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
GDM-1	NGS4T4FIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NX3zWo1RUW6qaXLpeIlwdiCxZjDoeY1idiCJRF2tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjJwNUm0OUDPxE1w	NXy1WnYxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
DMS-79	NFLobFVIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MXPJcohq[mm2aX;uJI9nKGi3bXHuJGROWy15OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlQvPDl\|NDFOwG0v	NXXHVGhwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
MPP-89	NILB[WlIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlUvPjh5NDFOwG0v	MoLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NB10	MnrBS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NWHFbpp{UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPi52NzFOwG0v	M{fYNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
LS-513	MUHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NETsUnRKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUWxN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjZwOEi0O{DPxE1w	NHjoV\|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
L-540	M{PaNmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MYfJcohq[mm2aX;uJI9nKGi3bXHuJGwuPTRyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOk46OTR\|IN88UU4>	NGi3TpU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
ES1	Mk\tS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NWmwd3RiUW6qaXLpeIlwdiCxZjDoeY1idiCHU{GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFI4NjV{MTFOwG0v	NY\uPFdYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NTERA-S-cl-D1	M3i1Nmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			Mm\DTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCzNE42ODl\|IN88UU4>	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-1	NWD5boRlT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MXvJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyMlk1PTRizszNMi=>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
Calu-6	Mn[0S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGNidHVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|MvOTh3NTFOwG0v	NU[4[ohwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
CTV-1	M1y3OGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NV\oc\|U3UW6qaXLpeIlwdiCxZjDoeY1idiCFVG[tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzNwOUe4PUDPxE1w	Mm\1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
YT	MoTUS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MYHJcohq[mm2aX;uJI9nKGi3bXHuJHlVKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB\|OD61NlA6KM7:TT6=	MonJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-6	NX7OTlFvT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MoLpTY5pcWKrdHnvckBw\iCqdX3hckBVTS14IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTC0NU4zPzl5IN88UU4>	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
HT-144	M3Hlfmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NXrte5J7UW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDRzLkW0PFYh\|ryPLh?=	M{T6elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-13	MVnHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MoLaTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFIvOjd7MTFOwG0v	NHzTbZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
KALS-1	M1Lhb2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MlXUTY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjF\|Mkig{txONg>?	NYDYPVlQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
MOLT-16	MVPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MVrJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2NjB5NUKg{txONg>?	M{D5Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
D-336MG	M1HQRWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M4HHZWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1\|M{\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwOUW5PUDPxE1w	MmfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-11	MX;Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MlnNTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjV\|IN88UU4>	M{XVRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EB2	M2TDNGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MlH5TY5pcWKrdHnvckBw\iCqdX3hckBGSjJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES2MlY6QSEQvF2u	NXn4SnBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SK-N-DZ	NFztcpNIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			Mmf4TY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1QC5yOU[xJO69VS5?	M1mzelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SW684	MonXS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NF;oOWZKdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1QC5{Nkm1JO69VS5?	M4TFZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-18	M1PzRWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1X1SmlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjR\|OUWg{txONg>?	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

In vivo

Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. ^[5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. ^[6]

Protocol

Kinase Assay:^[1]	- Collapse PDGF receptor kinase activity: PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl₂). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-³³P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:^[3]	- Collapse Cell lines: BON-1 cells and NCI-H727 cells Concentrations: ~100 μM Incubation Time: 48 hours Method: BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively. (Only for Reference)
Animal Research:^[5]	- Collapse Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female). Dosages: 70 or 100 mg/kg Administration: Administered via i.p. (Only for Reference)

References

- Collapse

Solubility (25°C)

In vitro	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Imatinib (STI571) Mesylate SDF

Molecular Weight	589.71
Formula	C₂₉H₃₁N₇O.CH₄SO₃
CAS No.	220127-57-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Gleevec, Glivec, CGP-57148B
Smiles	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Unknown status	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

Selective Bcr-Abl Inhibitor

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
Most Potent Bcr-Abl Inhibitor

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA-approved Bcr-Abl Inhibitor

Dasatinib : Approved by FDA for CML and Ph+ ALL.
Newest Bcr-Abl Inhibitor

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

Related Bcr-Abl Products

PX-478 2HCl ^New

PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.
Defactinib (VS-6063) ^New

Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
SU6656 ^New

SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Ponatinib (AP24534)

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
Nilotinib (AMN-107)

Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.

Features:A selective inhibitor of native and mutant Bcr-Abl.
Bafetinib (INNO-406)

Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.

Features:Dual Bcr-Abl/Lyn inhibitor.
Degrasyn (WP1130)

Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.

Features:WP1130 has an advantage over imatinib mesylate in that its activity is not inhibited by a variety of Abl kinase mutations, including T315I.
Rebastinib (DCC-2036)

Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.

Features:A conformational control inhibitor of Abl1 and T315I Abl1.
Olverembatinib dimesylate (HQP1351)

Olverembatinib dimesylate (HQP1351, GZD824) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
GNF-2

GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells.

Choose Your Country or Region

By Signaling Pathways

By product type

Imatinib (STI571) Mesylate