Imatinib (STI571) Mesylate

Name: Imatinib (STI571) Mesylate
Brand: Selleck Chemicals
SKU: S1026
Rating: 5 (184 reviews)

For research use only.

Catalog No.S1026 Synonyms: Gleevec, Glivec, CGP-57148B

184 publications

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.

Selleck's Imatinib (STI571) Mesylate has been cited by 184 publications

Science, 2020, 370(6513)eabc2754

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Cell Stem Cell, 2020, 10;S1934-5909(20)30144-2

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Cell Metab, 2018, 28(6):817-832

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Cancer Cell, 2014, 26(6):840-50

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Cell Stem Cell, 2012, 10(2):210-7

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Clin Cancer Res, 2021, 27(9):2533-2548

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Cancers (Basel), 2021, 13(14)3635

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Cell Death Dis, 2021, 12(5):456

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Cell Death Discov, 2021, 7(1):139

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Hum Mol Genet, 2021, ddab011

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Hum Mol Genet, 2021, ddab014

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Cancer Sci, 2021, 112(2):655-667

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Biochem Pharmacol, 2021, 190:114658

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Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

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Ann Hematol, 2021, 10.1007/s00277-020-04357-z

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PLoS One, 2021, 16(7):e0250442

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Hum Cell, 2021, 10.1007/s13577-021-00579-z

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Exp Ther Med, 2021, 22(1):735

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Immunohorizons, 2021, 5(8):687-702

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Blood, 2020, 8 pii: blood

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Clin Cancer Res, 2020, 21;clincanres31422019

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Genome Med, 2020, 18;12(1):17

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Cancer Res, 2020, canres.1992.2020

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Cell Rep, 2020, 24;30(12):3951-3963 e4

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J Hematol Oncol, 2020, 13(1):80

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Cancers (Basel), 2020, 25;12(5)

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Cancers (Basel), 2020, 13;12(2) pii: E436

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Cancers (Basel), 2020, 12(6):E1674

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PLoS Pathog, 2020, 16(8):e1008823

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Br J Cancer, 2020, 10.1038/s41416-020-0952-1

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Aging (Albany NY), 2020, 12(17):17662-17680

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Front Bioeng Biotechnol, 2020, 20;8:482

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Cancer Sci, 2020, 10.1111/cas.14750

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Front Oncol, 2020, 12;10:696

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J Cell Mol Med, 2020, 10.1111/jcmm.15830

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Int J Mol Sci, 2020, 21(1)

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Sci Rep, 2020, 10(1):11269

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Cancer Cell Int, 2020, 19;20:58

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Oncol Rep, 2020, 44(5):2152-2164

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Drug Des Devel Ther, 2020, 12;14:1799-1811

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J Pharm Biomed Anal, 2020, 195:113864

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J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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FEBS Open Bio, 2020, 10.1002/2211-5463.13052

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bioRxiv, 2020, 2020/9/20.4.7.30734

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Immun Inflamm Dis, 2020, 10.1002/iid3.383

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Biochem Biophys Res Commun, 2020, 529(3):699-706

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Ann N Y Acad Sci, 2020, 1467(1):77-93

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J Cell Mol Med, 2020, 10.1111/jcmm.15612

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J Pers Med, 2020, 10(4)E234

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Hemasphere, 2020, 4(6):e497

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Neoplasia, 2020, 22(10):470-483

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Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

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Nat Cell Biol, 2019, 21(6):778-790

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Mol Cell, 2019, 75(2):252-266

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Autophagy, 2019, 15(12):2076-2090

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Cell Rep, 2019, 29(13):4471-4481.e6

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Elife, 2019, 8e48725

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J Exp Clin Cancer Res, 2019, 18;38(1):85

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Cancers (Basel), 2019, 11(12)E2043

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Gastric Cancer, 2019, 10.1007/s10120-019-00977-1

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Hum Reprod, 2019, 34(3):506-518

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J Cell Mol Med, 2019, 23(12):8314-8327

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Sci Rep, 2019, 9(1):1897

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Eur J Pharmacol, 2019, 17:172559

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PLoS One, 2019, 14(10):e0224237

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Int J Med Sci, 2019, 16(8):1149-1156

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Cancer Invest, 2019, 37(2):99-112

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Res Vet Sci, 2019, 124:1-9

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JCI Insight, 2019, 4(23)131434

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Front Immunol, 2019, 10:1876

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Nat Biomed Eng, 2018, 2(8):578-588

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Sci Transl Med, 2018, 10(427)

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Acta Neuropathol, 2018, 135(5):779-798

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Blood, 2018, 131(14):1532-1544

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Clin Cancer Res, 2018, 1;24(1):145-157

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Cell Rep, 2018, 23(11):3127-3136

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Elife, 2018, 7e36656

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J Exp Clin Cancer Res, 2018, 25;37(1):170

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Cell Death Discov, 2018, 4:48

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Front Immunol, 2018,

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Mol Cancer Ther, 2018, 17(7):1526-1539

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Endocr Relat Cancer, 2018, 25(4):471-480

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Neoplasia, 2018, 20(8):857-870

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Pharmacol Res, 2018, 133:121-131

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Eur J Med Chem, 2018, 154:101-109

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Cancer Sci, 2018, 109(9):2792-2800

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J Cell Physiol, 2018, 233(9):7467-7479

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J Cell Sci, 2018,

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Biochem Pharmacol, 2018, 10.1016/j.bcp.2018.10.011

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Toxicol Sci, 2018, 165(1):232-243

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Am J Physiol Lung Cell Mol Physiol, 2018, 315(6):L965-L976

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Biomed Pharmacother, 2018, 106:403-410

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Cell Signal, 2018, 51:191-198

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PLoS One, 2018, 13(2):e0191890

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Biochem Biophys Res Commun, 2018, 502(1):110-115

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Int J Clin Exp Pathol, 2018, 11(1):179-188

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Hemasphere, 2018, 2(3):e41

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NPJ Syst Biol Appl, 2018, 4:1

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Nat Commun, 2017, 1;8(1):1232

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Dev Cell, 2017, 42(2):117-129

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Theranostics, 2017, 7(5):1333-1345

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Cancer Res, 2017, 77(5):1142-1154

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Cell Rep, 2017,

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Cancer Lett, 2017, 393:113-124

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Cell Death Dis, 2017, 8(10):e3117

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Arch Toxicol, 2017, 91(8):2921-2938

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Mol Cancer Ther, 2017, 16(4):671-680

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Sci Rep, 2017,

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Exp Cell Res, 2017, 353(2):72-78

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BMC Cancer, 2017,

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Bioconjug Chem, 2017, 28(10):2608-2619

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Molecules, 2017, 22(12)

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Leuk Lymphoma, 2017, 58(8):1903-1913

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Reprod Fertil Dev, 2017, 29(7):1356-1368

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Oncotarget, 2017, 8(54):91841-91859

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Zhonghua Xue Ye Xue Za Zhi, 2017, 38(12):1036-1042

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Oncotarget, 2017, 8(27):43662-43677

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Cell Stem Cell, 2017, 20(2):233-246

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Cell, 2017, 170(3):507-521

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Blood, 2016, 28;127(17):2131-43

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Hepatology, 2016, 64(2):488-500

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EMBO Mol Med, 2016, 1;8(2):105-16

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Stem Cell Res, 2016, 16(3):795-806

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Mol Cancer Ther, 2016, 15(10):2302-2313

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Mol Cancer Ther, 2016, 15(1):94-105

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Mol Pharm, 2016, 13(10):3457-3467

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Traffic, 2016, 17(4):351-68

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Cancer Sci, 2016, 107(6):782-90

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Transl Oncol, 2016, 9(6):540-547

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Oncol Rep, 2016, 35(1):197-204

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Mol Vis, 2016, 22:1213-1220

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Oncotarget, 2016, 7(29):45916-45925

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Oncotarget, 2016, 7(18):26709-23

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Nat Commun, 2015, 6:7002

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J Clin Invest, 2015, 125(6):2317-34

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Nat Commun, 2015, 6:8481

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Genes Dev, 2015, 29(7):732-45

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Cell Rep, 2015, 10.1016/j.celrep.2015.05.012

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Cell Rep, 2015, 11(1):98-110

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J Urol, 2015, 194(6):1797-805

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Phytother Res, 2015, 29(7):1062-72

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Phytother Res, 2015, 29(3):434-43

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PLoS One, 2015, 10(3):e0120531

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Biomed Res Int, 2015, 2015:368976

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Oncol Lett, 2015, 10(5):2835-2841

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Brain Behav, 2015, 3;5(11):e00359

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Sci Transl Med, 2014, 6(261):261ra152

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Nat Protoc, 2014, 10(1):149-68

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J Clin Invest, 2014, 124(8):3378-90

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Leukemia, 2014, 28(4):977-9

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Oncogene, 2014, 33(2):236-45

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Stem Cells, 2014, 32(9):2324-37

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Mol Cancer Ther, 2014, 13(10):2276-87

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Cancer Cell Int, 2014, 14(1):89

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Int J Oncol, 2014, 44(5):1661-8

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J Alzheimers Dis, 2014, 41(3):729-37

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PLoS One, 2014, 9(10):e109441

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PLoS One, 2014, 9(1):e84900

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Biochem Biophys Res Commun, 2014, 450(4):1600-5

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Biomed Res Int, 2014, 2014:682010

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Graefes Arch Clin Exp Ophthalmol, 2014, 10.1007/s00417-014-2674-7

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University of Alberta, 2014, Yahya Muhammad Fiteih

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Cancer Immunol Res, 2014, 2(12):1186-98

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Cancer Res, 2013, 73(12):3661-70

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Pigment Cell Melanoma Res, 2013, 26(4):518-26

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J Mol Cell Cardiol, 2013, 66:177-88

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J Biol Chem, 2013, 288(34):24503-17

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Drug Metab Dispos, 2013, 10.1124/dmd.113.054189

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Proteomics, 2013, 13(23-24):3554-62

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Leuk Res, 2013, 37(11):1532-7

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Sci Transl Med, 2012, 4(131):131ra50

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Leukemia, 2012, 27(4):932-40

PubMed: 23032722 ( click the link to review the publication )

J Invest Dermatol, 2012, 132(7):1850-9

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Biochemistry, 2012, 51(25):5153-9

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PLoS One, 2012, 7(8):e42310

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Exp Hematol, 2012, 41(4):335-45.e3

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Leuk Res, 2012, 37(2):183-9

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Anticancer Res, 2012, 33(1):175-81

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FASEB J, 2011, 25(10):3661-73

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Pharm Res, 2011, 28(2):337-63

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J Pharm Biomed Anal, 2011, 56(2):173-82

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PLoS One, 2010, 5(11):e14143

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Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description

Targets

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. ^[1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. ^[2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. ^[3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	NF3YO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MYG5OkBp	NIe0T4dKSzVyPUGuO{DPxE1?	NIXvWo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFIyOid-MkS5NFAzOTJ:L3G+
K562	MmDZR5l1d3SxeHnjbZR6KEG\|c3H5		NHW2dowzPCCq	NEPaW5NKSzVyPUCuNlEh\|ryP	NX7mWmNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MCF-7	Mmn2R5l1d3SxeHnjbZR6KEG\|c3H5		NUC3TJdtOjRiaB?=	NWjqUodoUUN3ME2wMlg{KM7:TR?=	M3;WZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwNlA4Lz5{MkCwNFIxPzxxYU6=
MDA-MB-23	MlnvR5l1d3SxeHnjbZR6KEG\|c3H5		MnrTNlQhcA>?	M2XJOmlEPTB;MT64JO69VQ>?	NX;wZ2YzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
K562r	NV[wS4tjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVzJR\|UxRTFywrFOwG0>	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl\|OUSxPEc,OjR7M{m0NVg9N2F-
K562	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M4nmVmVEPTB;MD6wPUDPxE1?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ5OESxOEc,OTZ4N{i0NVQ9N2F-
MCF-7	NIjGWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHLCcoMyOCEQvF2=	MnPZOFghcA>?	NETBcJJjdG:la4OgZ4VtdCCycn;sbYZmemG2aX;uJIlv[3KnYYPlJIlv\HWlZXSgZpkhSkp\|Wh?=	M1SydFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mke0NFM1Lz5{NUK3OFA{PDxxYU6=
K-562	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M4TSVGlEPTB;MTFOwG0>	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ\|OU[2Nkc,OjV{M{m2OlI9N2F-
K562	NIGyb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NGnlbYxKSzVyPUCuOeKh\|ryP	NVfZRZh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5N\|k1OThpPkK0PVM6PDF6PD;hQi=>
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GIST882	MkewSpVv[3Srb36gZZN{[Xl?			NXHBRWhkUW6qaXLpeIlwdiCxZjDoeY1idiCNSWSgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBIUVOWOEiyJINmdGy\|IHL5JGVNUVODLDDJR\|UxKD1iMD6wPVch\|ryPLh?=	NUPmNlhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882	MmDhSpVv[3Srb36gZZN{[Xl?			NF[1VWhKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiYYX0c5Bpd3OyaH;yfYxifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGK7IFXMTXNCNCCLQ{WwJF0hOC5yOUeg{txONg>?	NULsVnloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
insect	NUnhXIxZTnWwY4Tpc44h[XO\|YYm=		NFHOS2Y{OCCvaX7z	MkPUTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v	Ml;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
K562	M2SxRWN6fG:2b4jpZ4l1gSCjc4PhfS=>		MXW3NkBpenN?	NFLJS\|REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNUDPxE1w	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl\|MEG5NFI9N2F-
primary leukemia cells	M2XIRWN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3nxfVczKGi{cx?=	MkH6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIIfpcIQhfHmyZTDGUHQ{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG\|c3H5MEBKSzVyIE2gNE4yKM7:TT6=	NI\VNY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BV173	NFLadolCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NWjGToJzPDhiaILz	NHjPZmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLWNVc{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvOSEQvF2u	MoWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
BAF3	M3G2dGZ2dmO2aX;uJIF{e2G7		MmXGO\|IhcHK\|	M4XxdmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhVDV4N2CgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMTFOwG0v	NFGxW4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
K562	MkXJR5l1d3SxeHnjbZR6KGG\|c3H5		MkjBNlQhcHK\|	M2TCc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u	M2Xh[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkOyPVM2Lz5{Mk[zNlk{PTxxYU6=
BA/F3	MnLQSpVv[3Srb36gZZN{[Xl?		NVX4fZViPzJiaILz	NXPxcGF1UW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgVGRITlKkZYThJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkGwNkDPxE1w	MkLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BAF3	NH\4bZZHfW6ldHnvckBie3OjeR?=		MYK3NkBpenN?	MnTSTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhVDV5NmCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMUCyJO69VS5?	M{\KWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	NGXVVlVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MmmxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCJSWPUPFgzKGOnbHzzMEBKSzVyIE2gNE4yODhizszNMi=>	NX;JXnpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882	NXPJNVRXTnWwY4Tpc44h[XO\|YYm=			NX\NVHJ7UW6qaXLpeIlwdiCxZjDLTXQhUzZ2MlWgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO\|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCDVGCt[IVxdGW2aX;uJIF{e2G7LDDJR\|UxKD1iMD6xNFgh\|ryPLh?=	NYHoT4t1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
K562	NWW1[lZqS3m2b4TvfIlkcXS7IHHzd4F6			MmDPR5l1d3SxeHnjJIVn\mWldDDpckBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zMTFOwG0v	MnHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ7NUGxNVMoRjF{OUWxNVE{RC:jPh?=
KU812	NHjte4JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NVXXbHNUPzJiaILz	M4\CSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO\|YYmsJGdKPTBiPTCwMlEyKM7:TT6=	Mme1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3	Mn3ERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M{H6dVczKGi{cx?=	NUC5b\|RoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhUDN7NmCgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVEh\|ryPLh?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BAF3	NFPhTINHfW6ldHnvckBie3OjeR?=		MmjmO\|IhcHK\|	M{f3NWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=>	NHPwe5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
32D	M{SwW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		NWDJUG0{PDhiaILz	M3POZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViM{LEJINmdGy\|IITyZY5{\mWldHXkJJdqfGhicEKxNEBk\WyuczDlfJBz\XO\|aX7nJGJkei2jYnygZZN{\XO\|ZXSgZZMheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD6xNVIh\|ryPLh?=	M{j3[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
insect cells	NF\BdVBHfW6ldHnvckBie3OjeR?=		MVKzNEBucW6\|	NUmxVFQ2UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKE1\|NUHUJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuNVE1OyEQvF2u	NXHY[\|NGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
insect cells	M3:1e2Z2dmO2aX;uJIF{e2G7		NGTFfZI{OCCvaX7z	NHTPVI1KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhWTJ3MligcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD6xNVUh\|ryPLh?=	Mm\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
K562	NFmxfY9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnHOO\|IhcHK\|	MoXmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDCR3IuSUKOIHTldIVv\GWwdDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6xNkDPxE1w	MlTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O\|A2RC:jPh?=
BA/F3	MlfKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MmrqO\|IhcHK\|	MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDNNlQ1XiCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5zMkmg{txONg>?	MlzOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
K562	M3XiUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MnrhO\|IhcHK\|	MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVAhRSByLkG0JO69VS5?	MofDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
HEK293	MXPGeY5kfGmxbjDhd5NigQ>?			MkXaTY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJGRFWjJiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMUSxJO69VS5?	NF\KbHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
K562	M2nwZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NHnmRWM4OiCqcoO=	MnH4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xOFch\|ryPLh?=	M{XYeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BAF3	MWDGeY5kfGmxbjDhd5NigQ>?		NGHlPIQ4OiCqcoO=	NYPW[ZNIUW6qaXLpeIlwdiCxZjDUSWwu\nW\|ZXSgZ2tKXCCDOEK5VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvOTR6MjFOwG0v	MkP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Ba/F3	NVz3WHVJTnWwY4Tpc44h[XO\|YYm=		MVG0PEBpenN?	M3e4RmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRUO1OWchdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjF2OTFOwG0v	MkHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
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KU812	NHHqeIpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NELvT4U4OiCqcoO=	NU\aZW5TSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTZizszNMi=>	NX;abI9SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
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KU812	NU\oW4N4SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			M3PsZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOsJGlEPTBiPTCwMlM{PyEQvF2u	NGD2NYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3OlU5Pyd-MkGzO\|Y2QDd:L3G+
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K562	M3zGSWN6fG:2b4jpZ4l1gSCjc4PhfS=>		NUDUe5pGPDhidH:gO\|IhcHK\|	NHPNNmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDS1JvQVLMJJBwe2m2aY\lJGs2PjJiY3XscJMh[W[2ZYKgOFghfG9iN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuN\|g1PCEQvF2u	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd6OUSyPUc,OjJ5OEm0Nlk9N2F-
K562	NVvGUHIzS3m2b4TvfIlkcXS7IHHzd4F6		NV\YVIZoPzJiaILz	MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlM6KM7:TT6=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl\|MkOxN{c,OjJ7M{KzNVM9N2F-
BA/F3	MU\GeY5kfGmxbjDhd5NigQ>?		NHnFcFY4OiCqcoO=	Mo\hTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIG[2OVRCKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6zPVIh\|ryPLh?=	MkniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3	MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?	MVe1JJRwKDFyIIXN	MYC0PEBpenN?	NFSyW\|lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochVlCPLXHicEBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBifCB3IITvJFExKHWPIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkO5N{DPxE1w	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
K562	Mm\MSpVv[3Srb36gZZN{[Xl?			MlryTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOg[5Jwf3SqIIXzbY5oKE2WVDDhd5NigSxiSVO1NEA:KDBwNDFOwG0v	Ml\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3NUK3OlAoRjF2NUWyO\|YxRC:jPh?=
BAF3	NFzoN4NHfW6ldHnvckBie3OjeR?=		NEn0[Hg4OiCqcoO=	MoD1TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlQh\|ryPLh?=	NIXoUI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BA/F3	M2TFO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2n2OlczKGi{cx?=	MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDNN\|UyXCCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC52MkSg{txONg>?	M2HveFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
KCL22	NGXMc2FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NH3ZbJQ1QCCqcoO=	NFTIS\|lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvDUFIzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvPDNizszNMi=>	NF\zZ4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
Ba/F3	M2\LO2Z2dmO2aX;uJIF{e2G7		Mlr3OFghcHK\|	M{DRUGlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiUUK1NmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjR3NTFOwG0v	NGDleIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
Sf9	MY\GeY5kfGmxbjDhd5NigQ>?			Mk\oTY5pcWKrdHnvckBw\iCqdX3hckBC[mxia3nuZZNmKGW6cILld5Nm\CCrbjDT[lkh[2WubIOsJGlEPTBiPTCwMlQ4KM7:TT6=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN5Nk[4NEc,OTd\|N{[2PFA9N2F-
K562	NFjC[\|REgXSxdH;4bYNqfHliYYPzZZk>		MknQOFghcHK\|	NYP5RYRIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD60O{DPxE1w	M1fmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|N{O1PFI3Lz5{M{ezOVgzPjxxYU6=
K562	M1f3OmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MoPFOFghcHK\|	MkHjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkS3JO69VS5?	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEe2Okc,OjV5N{i3OlY9N2F-
K562	M3j6TGZ2dmO2aX;uJIF{e2G7			MVvJcohq[mm2aX;uJI9nKEKFUj3BRmwyKGG3dH;wbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczygTWM2OCB;IECuOFc{KM7:TT6=	M3jRWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO\|U{QDxxYU6=
insect cells	MmrLSpVv[3Srb36gZZN{[Xl?		NIr3XY8{OCCvaX7z	NVfL[m9TUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKEV{NUXLJI12fGGwdDDlfJBz\XO\|ZXSgbY4hcW6\|ZXP0JINmdGy\|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuOFg2QCEQvF2u	MlH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
Sf9	MX7GeY5kfGmxbjDhd5NigQ>?			MWHCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlcY91\SC\|aYTlJI9nKE5vdHXycYlv[WxiaHX4ZYhqe3SrZHnu[U11[WepZXSgRWJNOiCneIDy[ZN{\WRiaX6gWJJq[2ixcHz1d4liKG6rIHnu[oVkfGWmIGPmPUBk\WyuczDifUBqe2:2aHXycYFtKHSrdILheIlwdiClYXzvdolu\XS{aXOgZZN{[XluIFvkJF0hOC53IN88UU4>	MlLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUezOFMoRjJzNEG3N\|Q{RC:jPh?=
primary leukemia cells	MmL0R5l1d3SxeHnjbZR6KGG\|c3H5		NWm5TlN4PzJiaILz	NUjoWHE2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO\|aX7nJGZNXDNvREizOXkhdXW2YYTpc44h[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGlEPTBiPTCwMlUh\|ryPLh?=	NF:0TY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BA/F3	NXPzfm4{TnWwY4Tpc44h[XO\|YYm=		NGLCdoE4OiCqcoO=	NEjhbnlKdmirYnn0bY9vKG:oIGTFUE1NS0tiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjVizszNMi=>	Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
K562	NFvyWmZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MlfNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|LDDJR\|UxKD1iMD61JO69VS5?	NXOzWIxLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVI1QDNpPkKzN\|UzPDh\|PD;hQi=>
K562	MlfTR5l1d3SxeHnjbZR6KGG\|c3H5		NFvLNo04OiCqcoO=	MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjZYxk\WmwLVHNJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6MUWzNkc,OjN7OEG1N\|I9N2F-
K562	M1XxN2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MUm3NkBpenN?	MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyC3c3nu[{BE[WylZXnuJGFOKGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuOUDPxE1w	NH3uUIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1O\|YxOyd-MkW3OVc3ODN:L3G+
K562	Mnf1R5l1d3SxeHnjbZR6KGG\|c3H5			M2DzWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjVizszNMi=>	NUO0[FBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexPFk3PzRpPkK3NVg6Pjd2PD;hQi=>
BA/F3	MV;DfZRwfG:6aXPpeJkh[XO\|YYm=		NFjHNJM4OiCqcoO=	M3;RbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFLDVk1CSkxiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG\|c3H5MEBKSzVyIE2gNE42KM7:TT6=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
K562	NGS5PJNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnG2OFghcHK\|	M{\KcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	M{jXfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUOyNFcyLz5{M{mzNlA4OTxxYU6=
Sf9	NF3vN2dHfW6ldHnvckBie3OjeR?=			MWTUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO\|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u	M1HsN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562	MoPWR5l1d3SxeHnjbZR6KGG\|c3H5		M324c\|czKGi{cx?=	MkfUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE42OSEQvF2u	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjhzNEi5NEc,OjZ6MUS4PVA9N2F-
K562	M2LnemN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3;UWVQ5KGi{cx?=	M2XMUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPTNizszNMi=>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjdyN{i0Okc,OjZ5MEe4OFY9N2F-
K562	NYnVbFk1SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M1nLRlQ5KGi{cx?=	NUjPXG1zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlU{KM7:TT6=	M{m0TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUK1PFM5Lz5{OEWyOVg{QDxxYU6=
BA/F3	M1fpTmZ2dmO2aX;uJIF{e2G7		NWHrTJNZPzJiaILz	MWPJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiREixOmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkWzOUDPxE1w	M1XjUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
BA/F3	NEPVUY5HfW6ldHnvckBie3OjeR?=		NUjPV\|FzPzJiaILz	NYnCbo9KUW6qaXLpeIlwdiCxZjDQSGdHWmGucHjhJHY2PjGGL1S4OFJXKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD61Olch\|ryPLh?=	M4LCZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
K562	NVO2[45RS3m2b4TvfIlkcXS7IHHzd4F6		MYi0PEBpenN?	NW[xWYxLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53ODFOwG0v	NEHyVIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5OVM5OCd-MkGyPVU{QDB:L3G+
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SW684	M3jJU2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1LaRmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjJ4OUWg{txONg>?	NFL5PWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-18	MkLhS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MXjJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTC0PE41Ozl3IN88UU4>	M1jaZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

In vivo

Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. ^[5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. ^[6]

Protocol

Kinase Assay:^[1]	- Collapse PDGF receptor kinase activity: PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl₂). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-³³P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:^[3]	- Collapse Cell lines: BON-1 cells and NCI-H727 cells Concentrations: ~100 μM Incubation Time: 48 hours Method: BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively. (Only for Reference)
Animal Research:^[5]	- Collapse Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female). Dosages: 70 or 100 mg/kg Administration: Administered via i.p. (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Imatinib (STI571) Mesylate SDF

Molecular Weight	589.71
Formula	C₂₉H₃₁N₇O.CH₄SO₃
CAS No.	220127-57-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Gleevec, Glivec, CGP-57148B
Smiles	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

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Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
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C1=C0/X	C1:	LOG(C1):
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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Completed	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

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Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

Selective Bcr-Abl Inhibitor

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
Most Potent Bcr-Abl Inhibitor

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA-approved Bcr-Abl Inhibitor

Dasatinib : Approved by FDA for CML and Ph+ ALL.
Newest Bcr-Abl Inhibitor

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

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Imatinib (STI571) Mesylate