Imatinib (STI571) Mesylate

Name: Imatinib (STI571) Mesylate
Brand: Selleck Chemicals
SKU: S1026
Rating: 5 (159 reviews)

For research use only.

Catalog No.S1026 Synonyms: Gleevec, Glivec, CGP-57148B

159 publications

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.

Selleck's Imatinib (STI571) Mesylate has been cited by 159 publications

Science, 2020, 370(6513)eabc2754

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Cell Stem Cell, 2020, 10;S1934-5909(20)30144-2

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Cell Metab, 2018, 28(6):817-832

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Cancer Cell, 2014, 26(6):840-50

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Cell Stem Cell, 2012, 10(2):210-7

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Hum Mol Genet, 2021, ddab011

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Hum Mol Genet, 2021, ddab014

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Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

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Blood, 2020, 8 pii: blood

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Clin Cancer Res, 2020, 21;clincanres31422019

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Genome Med, 2020, 18;12(1):17

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Cancer Res, 2020, canres.1992.2020

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Cell Rep, 2020, 24;30(12):3951-3963 e4

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J Hematol Oncol, 2020, 13(1):80

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Cancers (Basel), 2020, 25;12(5)

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Cancers (Basel), 2020, 13;12(2) pii: E436

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Cancers (Basel), 2020, 12(6):E1674

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PLoS Pathog, 2020, 16(8):e1008823

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Br J Cancer, 2020, 10.1038/s41416-020-0952-1

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Aging (Albany NY), 2020, 12(17):17662-17680

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Front Bioeng Biotechnol, 2020, 20;8:482

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Cancer Sci, 2020, 10.1111/cas.14750

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Front Oncol, 2020, 12;10:696

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J Cell Mol Med, 2020, 10.1111/jcmm.15830

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Int J Mol Sci, 2020, 21(1)

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Sci Rep, 2020, 10(1):11269

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Cancer Cell Int, 2020, 19;20:58

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Oncol Rep, 2020, 44(5):2152-2164

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Drug Des Devel Ther, 2020, 12;14:1799-1811

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J Pharm Biomed Anal, 2020, 195:113864

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J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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FEBS Open Bio, 2020, 10.1002/2211-5463.13052

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bioRxiv, 2020, 2020/9/20.4.7.30734

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Immun Inflamm Dis, 2020, 10.1002/iid3.383

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Biochem Biophys Res Commun, 2020, 529(3):699-706

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Ann N Y Acad Sci, 2020, 1467(1):77-93

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J Cell Mol Med, 2020, 10.1111/jcmm.15612

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J Pers Med, 2020, 10(4)E234

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Hemasphere, 2020, 4(6):e497

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Neoplasia, 2020, 22(10):470-483

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Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

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Nat Cell Biol, 2019, 21(6):778-790

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Mol Cell, 2019, 75(2):252-266

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Autophagy, 2019, 15(12):2076-2090

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Cell Rep, 2019, 29(13):4471-4481.e6

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Elife, 2019, 8e48725

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J Exp Clin Cancer Res, 2019, 18;38(1):85

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Cancers (Basel), 2019, 11(12)E2043

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Gastric Cancer, 2019, 10.1007/s10120-019-00977-1

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Hum Reprod, 2019, 34(3):506-518

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J Cell Mol Med, 2019, 23(12):8314-8327

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Sci Rep, 2019, 9(1):1897

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Eur J Pharmacol, 2019, 17:172559

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PLoS One, 2019, 14(10):e0224237

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Int J Med Sci, 2019, 16(8):1149-1156

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Cancer Invest, 2019, 37(2):99-112

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Res Vet Sci, 2019, 124:1-9

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JCI Insight, 2019, 4(23)131434

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Front Immunol, 2019, 10:1876

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Nat Biomed Eng, 2018, 2(8):578-588

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Sci Transl Med, 2018, 10(427)

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Acta Neuropathol, 2018, 135(5):779-798

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Blood, 2018, 131(14):1532-1544

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Clin Cancer Res, 2018, 1;24(1):145-157

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Cell Rep, 2018, 23(11):3127-3136

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Elife, 2018, 7e36656

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J Exp Clin Cancer Res, 2018, 25;37(1):170

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Cell Death Discov, 2018, 4:48

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Front Immunol, 2018,

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Endocr Relat Cancer, 2018, 25(4):471-480

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Neoplasia, 2018, 20(8):857-870

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Pharmacol Res, 2018, 133:121-131

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Eur J Med Chem, 2018, 154:101-109

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Cancer Sci, 2018, 109(9):2792-2800

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J Cell Physiol, 2018, 233(9):7467-7479

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J Cell Sci, 2018,

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Biochem Pharmacol, 2018, 10.1016/j.bcp.2018.10.011

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Toxicol Sci, 2018, 165(1):232-243

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PLoS One, 2018, 13(2):e0191890

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Biochem Biophys Res Commun, 2018, 502(1):110-115

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Int J Clin Exp Pathol, 2018, 11(1):179-188

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Hemasphere, 2018, 2(3):e41

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Nat Commun, 2017, 1;8(1):1232

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Dev Cell, 2017, 42(2):117-129

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Theranostics, 2017, 7(5):1333-1345

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Cell Rep, 2017,

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Cancer Lett, 2017, 393:113-124

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Arch Toxicol, 2017, 91(8):2921-2938

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Mol Cancer Ther, 2017, 16(4):671-680

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Sci Rep, 2017,

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Exp Cell Res, 2017, 353(2):72-78

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BMC Cancer, 2017,

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Molecules, 2017, 22(12)

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Reprod Fertil Dev, 2017, 29(7):1356-1368

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Oncotarget, 2017, 8(54):91841-91859

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Oncotarget, 2017, 8(27):43662-43677

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Cell Stem Cell, 2017, 20(2):233-246

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Cell, 2017, 170(3):507-521

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Blood, 2016, 28;127(17):2131-43

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Hepatology, 2016, 64(2):488-500

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EMBO Mol Med, 2016, 1;8(2):105-16

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Stem Cell Res, 2016, 16(3):795-806

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Mol Cancer Ther, 2016, 15(10):2302-2313

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Mol Cancer Ther, 2016, 15(1):94-105

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Mol Pharm, 2016, 13(10):3457-3467

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Traffic, 2016, 17(4):351-68

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Cancer Sci, 2016, 107(6):782-90

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Oncol Rep, 2016, 35(1):197-204

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Mol Vis, 2016, 22:1213-1220

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Oncotarget, 2016, 7(29):45916-45925

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Oncotarget, 2016, 7(18):26709-23

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Nat Commun, 2015, 6:7002

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J Clin Invest, 2015, 125(6):2317-34

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Nat Commun, 2015, 6:8481

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Genes Dev, 2015, 29(7):732-45

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Cell Rep, 2015, 10.1016/j.celrep.2015.05.012

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Phytother Res, 2015, 29(7):1062-72

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Phytother Res, 2015, 29(3):434-43

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PLoS One, 2015, 10(3):e0120531

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Biomed Res Int, 2015, 2015:368976

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Oncol Lett, 2015, 10(5):2835-2841

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Brain Behav, 2015, 3;5(11):e00359

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Sci Transl Med, 2014, 6(261):261ra152

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Nat Protoc, 2014, 10(1):149-68

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J Clin Invest, 2014, 124(8):3378-90

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Leukemia, 2014, 28(4):977-9

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Oncogene, 2014, 33(2):236-45

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Stem Cells, 2014, 32(9):2324-37

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Mol Cancer Ther, 2014, 13(10):2276-87

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Cancer Cell Int, 2014, 14(1):89

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Int J Oncol, 2014, 44(5):1661-8

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J Alzheimers Dis, 2014, 41(3):729-37

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Biomed Res Int, 2014, 2014:682010

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University of Alberta, 2014, Yahya Muhammad Fiteih

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Proteomics, 2013, 13(23-24):3554-62

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Leuk Res, 2013, 37(11):1532-7

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Sci Transl Med, 2012, 4(131):131ra50

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Leukemia, 2012, 27(4):932-40

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J Invest Dermatol, 2012, 132(7):1850-9

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Biochemistry, 2012, 51(25):5153-9

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Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description

Targets

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. ^[1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. ^[2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. ^[3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHTpW4o6PiCq	NHWxXm9KSzVyPUGuO{DPxE1?	M3fPelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwNlEzLz5{NEmwNFIyOjxxYU6=
K562	NWnXV\|ZUS3m2b4TvfIlkcXS7IFHzd4F6		M3f3WFI1KGh?	MYjJR\|UxRTBwMkGg{txO	NWm2W5NyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MCF-7	M3\OcGN6fG:2b4jpZ4l1gSCDc4PhfS=>		M3H4eFI1KGh?	MVvJR\|UxRTBwOEOg{txO	MmH0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
MDA-MB-23	NFPBXZBEgXSxdH;4bYNqfHliQYPzZZk>		Ml\PNlQhcA>?	M4TVdWlEPTB;MT64JO69VQ>?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
K562r	NHjtO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MnTGTWM2OD1zMNMg{txO	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl\|OUSxPEc,OjR7M{m0NVg9N2F-
K562	MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MlziSWM2OD1yLkC5JO69VQ>?	NXfoO2s1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2O\|g1OTRpPkG2Olc5PDF2PD;hQi=>
MCF-7	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYL4e3p[OTBizszN	MoK2OFghcA>?	MYLicI9kc3NiY3XscEBxem:uaX\ldoF1cW:wIHnuZ5Jm[XOnIHnu[JVk\WRiYomgRmo{Yg>?	Ml[3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{SwN\|QoRjJ3Mke0NFM1RC:jPh?=
K-562	NELrdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			M2XwdmlEPTB;MTFOwG0>	MoC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{m2OlIoRjJ3MkO5OlYzRC:jPh?=
K562	NXjiRXczT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			NED2[INKSzVyPUCuOeKh\|ryP	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl\|OUSxPEc,OjR7M{m0NVg9N2F-
PC3	MkH1RZBweHSxc3nzJGF{e2G7	Ml\VNlDjiIoQvF2=	MVe0PE84OiCq	NFr2WI5qdmO{ZXHz[ZMh[2WubDDzeZJ3cX[jbB?=	M3[0U\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{i2OlU3Lz5{NUe4OlY2PjxxYU6=
PC3	NXfaPWY1S2WubDDWbYFjcWyrdImgRZN{[Xl?	MVqyNQKBkc7:TR?=	MY[2MVczKGh?	Ml63bY5kemWjc3XzJINmdGxidnnhZoltcXS7	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
DU145	MV\BdI9xfG:\|aYOgRZN{[Xl?	M{Pn[lIx6oDLzszN	MWq0PE84OiCq	M3\kfolv\HWlZYOgZ4VtdCCmZXH0bEBjgSCjcH;weI9{cXN?	NV;DcpZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O\|g3PjV4PD;hQi=>
DU145	NUHOdWV5S2WubDDWbYFjcWyrdImgRZN{[Xl?	MV6yNQKBkc7:TR?=	NIrFT5c3NTd{IHi=	M1jsfIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eR?=	NUSwbmd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O\|g3PjV4PD;hQi=>
Hep G2	NWXoc3lIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MUXJR\|UxRTNzIN88US=>	NVP1NWlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OlMzOzJpPkK1PFY{OjN{PD;hQi=>
T47D	Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?			MV3JR\|UxRTVyIN88US=>	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh4M{KzNkc,OjV6NkOyN\|I9N2F-
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K562	NVPKbotmS3m2b4TvfIlkcXS7IHHzd4F6		NGr1cY04OiCqcoO=	M33Vc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMD6xJO69VS5?	NUf0co95RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
primary leukemia cells	NH;qV\|REgXSxdH;4bYNqfHliYYPzZZk>		MlHEO\|IhcHK\|	NIm0SlFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBxemmvYYL5JIxmfWunbXnhJINmdGy\|IHnzc4xifGWmIH\yc40h[WO3dHWgcZlmdG:rZDDs[ZVs\W2rYTDwZZRq\W62IHX4dJJme3Orbnege4lt\CC2eYDlJGZNXDNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGy3Y3nm[ZJie2ViYYPzZZktKEmFNUCgQUAxNjFizszNMi=>	NH:5[3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BV173	MmjpRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MoH6OFghcHK\|	NIfBSnRCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLWNVc{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvOSEQvF2u	NV7ybGJ7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
BAF3	MlSySpVv[3Srb36gZZN{[Xl?		M1OxNVczKGi{cx?=	NXHpdmRkUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ2tKXCCONU[3VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSUZ\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHTlZ5Jm[XOnIHnuJINmdGxicILvcIln\XKjdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6xJO69VS5?	NIrnbo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
K562	MYDDfZRwfG:6aXPpeJkh[XO\|YYm=		NX[5OoJwOjRiaILz	NXXLSZJiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zIN88UU4>	M4nmTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkOyPVM2Lz5{Mk[zNlk{PTxxYU6=
BA/F3	NYGzbI9RTnWwY4Tpc44h[XO\|YYm=		NInpc4w4OiCqcoO=	MVPJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoJmfGFiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W\|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvOTB{IN88UU4>	M4HrdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
BAF3	NF3G[JBHfW6ldHnvckBie3OjeR?=		NUnRenl7PzJiaILz	MWTJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBNPTd4UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMEKg{txONg>?	NVO4W5NuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882	MUjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NILO[oJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q5QDJiY3XscJMtKEmFNUCgQUAxNjFyODFOwG0v	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
GIST882	MXnGeY5kfGmxbjDhd5NigQ>?			MmXHTY5pcWKrdHnvckBw\iCNSWSgT\|Y1OkVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEeLU2S4PFIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDifUBCXFBvZHXwcIV1cW:wIHHzd4F6NCCLQ{WwJF0hOC5zMEig{txONg>?	M2nmdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NkGxO\|cyLz5{M{[xNVc4OTxxYU6=
K562	NI\kbmFEgXSxdH;4bYNqfHliYYPzZZk>			MVrDfZRwfG:6aXOg[YZn\WO2IHnuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjFzIN88UU4>	M2XOblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{OUWxNVE{Lz5zMkm1NVEyOzxxYU6=
KU812	M4npRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mo\qO\|IhcHK\|	NHLZcW5CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yOSEQvF2u	M1PDV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BA/F3	M4K1[mFvfGmycn;sbYZmemG2aY\lJIF{e2G7		Mo\PO\|IhcHK\|	NWL6N44{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W\|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhUDN7NmCgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVEh\|ryPLh?=	M1ruOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BAF3	NG\uPGxHfW6ldHnvckBie3OjeR?=		MnXGO\|IhcHK\|	NX\1fpF[UW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgR3NHOVJiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOC5zMTFOwG0v	NGLh[oQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
32D	NUexN5ZMSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MlfNOFghcHK\|	NHPOT2xCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAh[2WubIOg[ZhxemW\|c3nu[{BD[3JvYXLsJIF{e2W\|c3XkJIF{KHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVEzKM7:TT6=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
insect cells	NWHnZ\|lqTnWwY4Tpc44h[XO\|YYm=		MYmzNEBucW6\|	NF\EZ4pKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhVTN3MWSgcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD6xNVQ{KM7:TT6=	M4fOOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
insect cells	MkPpSpVv[3Srb36gZZN{[Xl?		MVKzNEBucW6\|	MmHNTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJHEzPTKKIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwMUG1JO69VS5?	NHPPdZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
K562	MoO2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MYe3NkBpenN?	NEHsbo9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJEWi2DQlyg[IVx\W6mZX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlEzKM7:TT6=	NGXnfo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|cxPSd-MkewO\|c4ODV:L3G+
BA/F3	NYTKU4NySW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NFrU[5k4OiCqcoO=	NHfxZWVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBOOjR2VjDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR\|UxKD1iMD6xNlkh\|ryPLh?=	M3XpelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
K562	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NWjrV\|IzPzJiaILz	MmT3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6xOEDPxE1w	Mn3yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
HEK293	M4DqPGZ2dmO2aX;uJIF{e2G7			MWPJcohq[mm2aX;uJI9nKGG3dH;wbI9{eGixconsZZRqd25ib3[gSGRTOiCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KGK7IFXMTXNCNCCLQ{WwJF0hOC5zNEGg{txONg>?	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
K562	NYHJWXJMSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MVG3NkBpenN?	NX7HfYY4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yPDdizszNMi=>	MmDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3	MYTGeY5kfGmxbjDhd5NigQ>?		MlTBO\|IhcHK\|	MoT2TY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiY1vJWEBCQDJ7UDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuNVQ5OiEQvF2u	M2LQd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
Ba/F3	NHywbXJHfW6ldHnvckBie3OjeR?=		MUK0PEBpenN?	NWDydIFVUW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDFN\|U2TyCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG\|ZTDhd5NigSxiR1m1NEA:KDBwMUS5JO69VS5?	NGTCUoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
KU812	M4jTW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7		MWW3NkBpenN?	NVfoRplvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFAvOTZizszNMi=>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
KU812	NVrxUZp2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M1vy[VczKGi{cx?=	MnPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDCR3IuSUKOIHTldIVv\GWwdDDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuNVYh\|ryPLh?=	NX3wR5pVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
A10	MkTLSpVv[3Srb36gZZN{[Xl?		M2rFVVY5KGi{cx?=	MmXoTY5pcWKrdHnvckBw\iCSRFfGVk1j\XSjIHTybZZmdiCycn;sbYZmemG2aX;uJI9nKHKjdDDBNVAh[2WubIOgZYZ1\XJiNkigbJJ{KGmwIIDy[ZNmdmOnIH;mJJJifCC{ZXPvcYJqdmGwdDDQSGdHNUKEIHL5JINmdGxidHn0[ZIu\2yxIHz1cYlv\XOlZX7j[UBie3OjeTygTWM2OCB;IECuNVYzKM7:TT6=	MonwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd3MEK3NFAoRjJ5NUCyO\|AxRC:jPh?=
KU812	NWXGcnNqSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		Ml\iO\|IhcHK\|	MnrzRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNVUixNkBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6xOlMh\|ryPLh?=	NE\oOGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
K562	NGnF[45EgXSxdH;4bYNqfHliYYPzZZk>			NVvBW4MzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyxiSVO1NEA:KDBwMUeg{txONg>?	NV3afXRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFA5ODZpPkKzOlAxQDB4PD;hQi=>
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K562	NYHDcoUyS3m2b4TvfIlkcXS7IHHzd4F6			MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBMPTZ{IHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVgh\|ryPLh?=	Mo\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd3N{KwPFgoRjF5NUeyNFg5RC:jPh?=
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CHO	NXf2d\|UyTnWwY4Tpc44h[XO\|YYm=			NEHPTGxKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDQcIF1\WyndD3k[ZJqfmWmIHfyc5d1cCCoYXP0c5IhemWlZYD0c5Ih[mW2YTDwbI9{eGixconsZZRqd25iaX6gR2hQKGOnbHzzMEBKSzVyIE2gNE4zPCEQvF2u	NHrKbIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkG2Olk2OCd-MUKxOlY6PTB:L3G+
MEG01	M{LwUmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M4\oOFczKGi{cx?=	NGjINIlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3FS\|AyKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG\|c3H5MEBIUTVyIE2gNE4zPCEQvF2u	NFHSfms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
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K562	NVHLXpV{SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=			Mn;KRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|LDDJR\|UxKD1iMD6yOFQh\|ryPLh?=	NVHNNXgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
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K562	M2nBVWZ2dmO2aX;uJIF{e2G7		M{H2eFMxKG2rboO=	NYm1[FFtUW6qaXLpeIlwdiCxZjDrbY5w[mWjZDDibY5lcW6pIITvJGFDVCCrbjDoeY1idiCNNU[yJINmdGy\|IHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCrVGLBVUBz\WGpZX70MYJie2WmIH3hd5Mhe3CnY4Tyc41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkK1JO69VS5?	Mn\wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
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CHO	MmKxSpVv[3Srb36gZZN{[Xl?			M2G4ZmlvcGmkaYTpc44hd2ZiY3jpcYVzcWNiUFTHSkBz\WOncITvdkB4cXSqIHOtb4l1KGO7dH;wcIF{dWmlIHTvcYFqdiCyaH;zdIhwenmuYYTpc44hcW5iQ1jPJINmdGy\|LDDJR\|UxKD1iMD6yOkDPxE1w	NXvTWZpHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKxOlY6PTBpPkGyNVY3QTVyPD;hQi=>
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K562	Moj0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M2DHblczKGi{cx?=	M37wXmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BweiCFQ1u4JIF{e2G7LDDHTVUxKD1iMD6yOlch\|ryPLh?=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
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K562	M4XPPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NEX0T2w4OiCqcoO=	M1rFR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDlfJBz\XO\|aX7nJJdqdGRidInw[UBD[3JvQXLsJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFAvOjhizszNMi=>	M2i1ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUm1NVM3Lz5{NkG5OVE{PjxxYU6=
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HEK293	NXHvd21WTnWwY4Tpc44h[XO\|YYm=		M3rnb\|EvPSCvaX7z	M2\yOmlvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRULLMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMhfXBidH:gOVAxKHWPIHHmeIVzKDFwNTDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuN\|Uh\|ryPLh?=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
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insect cells	M1nKUmZ2dmO2aX;uJIF{e2G7		NV;rRo9WOzBibXnudy=>	Mk\4TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJGczPTCHIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwM{W5PUDPxE1w	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
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K562	Mn7FSpVv[3Srb36gZZN{[Xl?			NIizOlhKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Boem:5dHigeZNqdmdiTWTUJIF{e2G7LDDJR\|UxKD1iMD60JO69VS5?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV3Mke2NEc,OTR3NUK3OlA9N2F-
BAF3	NUHmU3M5TnWwY4Tpc44h[XO\|YYm=		NVv6bmxGPzJiaILz	MkD6TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6\|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT\|gh[XO\|YYmsJGdKPTBiPTCwMlQh\|ryPLh?=	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BA/F3	NHzORoVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NGi4bY84OiCqcoO=	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy\|IHX4dJJme3OrbnegRoNzNUGkbDDNN\|UyXCCvdYThcpQh[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC52MkSg{txONg>?	M2LLUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
KCL22	MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NVf6XVdWPDhiaILz	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuFTEKyJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCFZXzsMXRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygS2k2OCB;IECuOFMh\|ryPLh?=	MnjyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
Ba/F3	M1zQOGZ2dmO2aX;uJIF{e2G7		NV;WWIcyPDhiaILz	NFfydJlKdmirYnn0bY9vKG:oIFLDVk1CSkxzIGGyOVJJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKFUj3BRmwyNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKrdHXMbYdpfCCudXPp[oVz[XOnIHHzd4F6NCCJSUWwJF0hOC52NUWg{txONg>?	NXvCXoNkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN\|c6QDFpPkOwNVM4QThzPD;hQi=>
Sf9	M4HHXWZ2dmO2aX;uJIF{e2G7			MWjJcohq[mm2aX;uJI9nKGi3bXHuJGFjdCCtaX7hd4Uh\XiycnXzd4VlKGmwIGPmPUBk\WyuczygTWM2OCB;IECuOFch\|ryPLh?=	NIPmWnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O3OlY5OCd-MUezO\|Y3QDB:L3G+
K562	NYDtdGVoS3m2b4TvfIlkcXS7IHHzd4F6		MWq0PEBpenN?	MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjR5IN88UU4>	MkjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{W4NlYoRjJ\|N{O1PFI3RC:jPh?=
K562	NX;DXWJSSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		MoHZOFghcHK\|	NHHQeWtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOFch\|ryPLh?=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEe2Okc,OjV5N{i3OlY9N2F-
K562	NXjjTlJDTnWwY4Tpc44h[XO\|YYm=			NGH0dm1KdmirYnn0bY9vKG:oIFLDVk1CSkxzIHH1eI9xcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gT\|U3OiClZXzsd{whUUN3MDC9JFAvPDd\|IN88UU4>	NIHrRZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO\|U{QCd-MkC4NVc2Ozh:L3G+
insect cells	MkP6SpVv[3Srb36gZZN{[Xl?		NITreVE{OCCvaX7z	Mnz3TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJGUzPTWNIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwNEi1PEDPxE1w	MoPKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|MEG3NFMoRjJ\|M{CxO\|A{RC:jPh?=
Sf9	MkDCSpVv[3Srb36gZZN{[Xl?			M{\BfmJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gdoVud3SnIIPpeIUhd2ZiTj30[ZJucW6jbDDo[ZhicGm\|dHnkbY5mNXSjZ3fl[EBCSkx{IHX4dJJme3OnZDDpckBVemmlaH;wcJV{cWFibnmgbY5n\WO2ZXSgV4Y6KGOnbHzzJIJ6KGm\|b4To[ZJu[WxidHn0doF1cW:wIHPhcI9zcW2ndILpZ{Bie3OjeTygT4QhRSByLkWg{txONg>?	NEm2XIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSxO\|M1Oyd-MkG0NVc{PDN:L3G+
primary leukemia cells	NHfJWJBEgXSxdH;4bYNqfHliYYPzZZk>		MU[3NkBpenN?	NVr6WW9vS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO\|aX7nJGZNXDNvREizOXkhdXW2YYTpc44h[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGlEPTBiPTCwMlUh\|ryPLh?=	NEjMU3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BA/F3	NH;FSFhHfW6ldHnvckBie3OjeR?=		M2n3U\|czKGi{cx?=	NGPTR41KdmirYnn0bY9vKG:oIGTFUE1NS0tiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjVizszNMi=>	MkX3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
K562	M2jnRWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NXKyTY9USW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE42KM7:TT6=	M{HFcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{WyOFg{Lz5{M{O1NlQ5OzxxYU6=
K562	NGe1[IhEgXSxdH;4bYNqfHliYYPzZZk>		Mln3O\|IhcHK\|	MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjZYxk\WmwLVHNJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	NILsOYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m4NVU{Oid-MkO5PFE2OzJ:L3G+
K562	M3\FUGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NF[5cpk4OiCqcoO=	NWPmeI1oS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA4OiCqcoOgeZNqdmdiQ3HsZ4VqdiCDTTDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUCgQUAxNjVizszNMi=>	NVXOO5o6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3OVc3ODNpPkK1O\|U4PjB\|PD;hQi=>
K562	MXLDfZRwfG:6aXPpeJkh[XO\|YYm=			MkPRR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{whUUN3MDC9JFAvPSEQvF2u	M1LJWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MUi5Olc1Lz5{N{G4PVY4PDxxYU6=
BA/F3	MWLDfZRwfG:6aXPpeJkh[XO\|YYm=		MWG3NkBpenN?	NVTHPZR4S3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgRmNTNUGETDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAxNjVizszNMi=>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN\|MEG3NFM9N2F-
K562	MoTwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NVX3V2g1PDhiaILz	MoXKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkWg{txONg>?	M{jyRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUOyNFcyLz5{M{mzNlA4OTxxYU6=
Sf9	NFS4[JdHfW6ldHnvckBie3OjeR?=			MVvUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO\|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u	M4jiXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562	MU\DfZRwfG:6aXPpeJkh[XO\|YYm=		MV23NkBpenN?	NX\OS2JTS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53MTFOwG0v	NGXSZWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkixOFg6OCd-Mk[4NVQ5QTB:L3G+
K562	M{PrSGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NHLnfoU1QCCqcoO=	NInVSJhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjV\|IN88UU4>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjdyN{i0Okc,OjZ5MEe4OFY9N2F-
K562	NYD4[IVmSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		NGPkVoM1QCCqcoO=	MnjLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkWzJO69VS5?	NWHJV2dMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1NlU5OzhpPkK4OVI2QDN6PD;hQi=>
BA/F3	NICxVWFHfW6ldHnvckBie3OjeR?=		NWHVUYdxPzJiaILz	M{[0XWlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKGGwZDDEPFE3UCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuOVM2KM7:TT6=	NXv5OYhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3	MUPGeY5kfGmxbjDhd5NigQ>?		Mk\BO\|IhcHK\|	M37zb2lvcGmkaYTpc44hd2ZiUFTHSnJidHCqYTDWOVYyTC:GOESyWkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwNU[3JO69VS5?	M4\zWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
K562	M{TZS2N6fG:2b4jpZ4l1gSCjc4PhfS=>		MXS0PEBpenN?	NUC4S21GS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53ODFOwG0v	M3HlWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkm1N\|gxLz5{MUK5OVM5ODxxYU6=
BA/F3	MV;DfZRwfG:6aXPpeJkh[XO\|YYm=		NWDKWW12PzJiaILz	M1zGeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z\|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCHM{W5WkBufXSjboSgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC53OTFOwG0v	NH3UO3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
BA/F3	NY\KSnFJTnWwY4Tpc44h[XO\|YYm=		NFqyNVM4OiCqcoO=	NEXafGdKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNE1OOzVzVDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjZ{NTFOwG0v	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BAF3	NXPXUWRsTnWwY4Tpc44h[XO\|YYm=		MW[3NkBpenN?	NEO5UGpKdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNEBnfXOrb36gdJJwfGWrbjDNN\|U3XCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG\|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG\|c3H5MEBIUTVyIE2gNE43OjVizszNMi=>	M33UVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
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BA/F3	NFjQe21HfW6ldHnvckBie3OjeR?=		MU[3NkBpenN?	NFzmfGhKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgXVgzO0RibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO\|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO\|YYmsJGdKPTBiPTCwMlY3QSEQvF2u	M3PRU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5\|MEKwOFQ1OTxxYU6=
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K562	MnX6R5l1d3SxeHnjbZR6KGG\|c3H5		NF3jVWg1QCCqcoO=	M{DyZWN6fG:2b4jpZ4l1gSCrbjDkdpVoKHOnboPpeIl3\SCqdX3hckBMPTZ{IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBZXFRiYYPzZZktKEmFNUCgQUAyNjFizszNMi=>	NFzmVmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1OVk5OSd-Mkm2OVU6QDF:L3G+
IR-K562	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=			NWfrUYxqS3m2b4TvfIlkcXS7IHHnZYlve3RiaX3heIlvcWJicnXzbZN1[W62IHj1cYFvKEmULVu1OlIh[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6NCCLQ{WwJF0hOS5zIN88UU4>	NFH4ZVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK2OFUxOyd-Mk[yOlQ2ODN:L3G+
K562	M{LxPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MUi0PEBpenN?	MlnCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSBzLkG2JO69VS5?	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ\|MUC3PUc,OjZ{M{GwO\|k9N2F-
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TE-441-T	MonpS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M1zFfmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNESxMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkK4PFYh\|ryPLh?=	M2TxbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
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LC4-1	MlPKS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NF[5UXpKdmirYnn0bY9vKG:oIHj1cYFvKEyFND2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyQC5yNkWyJO69VS5?	M4XqbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
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SCLC-21H	NGO5WWlIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NFTHSZNKdmirYnn0bY9vKG:oIHj1cYFvKFOFTFOtNlFJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{MD6xNlQ3KM7:TT6=	Moi3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
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ALL-PO	M2excmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M1rMNWlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC56MUS5JO69VS5?	M33ofFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
GDM-1	NIP2XFhIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NGTBdXlKdmirYnn0bY9vKG:oIHj1cYFvKEeGTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOi53OUS1JO69VS5?	M2r5b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
DMS-79	M1OwWWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MUDJcohq[mm2aX;uJI9nKGi3bXHuJGROWy15OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlQvPDl\|NDFOwG0v	NEXTVI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
MPP-89	Ml3hS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NFrGfIVKdmirYnn0bY9vKG:oIHj1cYFvKE2SUD24PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjVwNki3OEDPxE1w	NF7DUGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
NB10	M1uxUGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NVfwTJpnUW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPi52NzFOwG0v	M{niOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
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Calu-6	M1X3UWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NGXiXnNKdmirYnn0bY9vKG:oIHj1cYFvKEOjbIWtOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzNwMUi1OUDPxE1w	M3TXU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CTV-1	Ml7XS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			M{jYWmlvcGmkaYTpc44hd2ZiaIXtZY4hS1SYLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFM{Njl5OEmg{txONg>?	MnjMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
YT	NYjLVmtMT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NVjpPGdHUW6qaXLpeIlwdiCxZjDoeY1idiC\VDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|gvPTJyOTFOwG0v	M1nRR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-6	NXKxVXltT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M{ezcWlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFEvOjd7NzFOwG0v	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
HT-144	MUDHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MXHJcohq[mm2aX;uJI9nKGi3bXHuJGhVNTF2NDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFEvPTR6NjFOwG0v	NHPZZ5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-13	M{e4R2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NYXLOHJVUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDJwMke5NUDPxE1w	NHrYcVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
KALS-1	NYfKXWl{T3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			Ml;lTY5pcWKrdHnvckBw\iCqdX3hckBMSUyVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ{NjF\|Mkig{txONg>?	NY\ZW3ZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
MOLT-16	NIfZRVNIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M4DPWGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwMEe1NkDPxE1w	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-336MG	MX;Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NU\PXop5UW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2NT65OVk6KM7:TT6=	NWrRSWliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
TE-11	MUfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MoPaTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjV\|IN88UU4>	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EB2	MWXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NX;J[FVlUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ7OTFOwG0v	NEPmeZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
SK-N-DZ	MWPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MnW2TY5pcWKrdHnvckBw\iCqdX3hckBUUy2QLVTaJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1QC5yOU[xJO69VS5?	M1jR[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SW684	NXz1PWhwT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NXftSFA4UW6qaXLpeIlwdiCxZjDoeY1idiCVV{[4OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDhwMk[5OUDPxE1w	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
EW-18	NICzXpZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M1LtPGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjR\|OUWg{txONg>?	NVXl[\|N1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

In vivo

Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. ^[5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. ^[6]

Protocol

Kinase Assay:^[1]	- Collapse PDGF receptor kinase activity: PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl₂). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-³³P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:^[3]	- Collapse Cell lines: BON-1 cells and NCI-H727 cells Concentrations: ~100 μM Incubation Time: 48 hours Method: BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively. (Only for Reference)
Animal Research:^[5]	- Collapse Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female). Dosages: 70 or 100 mg/kg Administration: Administered via i.p. (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Imatinib (STI571) Mesylate SDF

Molecular Weight	589.71
Formula	C₂₉H₃₁N₇O.CH₄SO₃
CAS No.	220127-57-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Gleevec, Glivec, CGP-57148B
Smiles	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Unknown status	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

Selective Bcr-Abl Inhibitor

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
Most Potent Bcr-Abl Inhibitor

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA-approved Bcr-Abl Inhibitor

Dasatinib : Approved by FDA for CML and Ph+ ALL.
Newest Bcr-Abl Inhibitor

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

Related Bcr-Abl Products

PX-478 2HCl ^New

PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.
Defactinib (VS-6063) ^New

Defactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
SU6656 ^New

SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Ponatinib (AP24534)

Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively. Ponatinib (AP24534) inhibits autophagy.
Nilotinib (AMN-107)

Nilotinib (AMN-107) is a selective Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.

Features:A selective inhibitor of native and mutant Bcr-Abl.
Bafetinib (INNO-406)

Bafetinib (INNO-406, NS-187) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.

Features:Dual Bcr-Abl/Lyn inhibitor.
Degrasyn (WP1130)

Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.

Features:WP1130 has an advantage over imatinib mesylate in that its activity is not inhibited by a variety of Abl kinase mutations, including T315I.
Rebastinib (DCC-2036)

Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.

Features:A conformational control inhibitor of Abl1 and T315I Abl1.
GZD824 Dimesylate(HQP1351)

GZD824 Dimesylate (HQP1351) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
GNF-2

GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells.

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Imatinib (STI571) Mesylate