Imatinib (STI571) Mesylate

For research use only.

Catalog No.S1026 Synonyms: Gleevec, Glivec, CGP-57148B

184 publications

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.

Selleck's Imatinib (STI571) Mesylate has been cited by 184 publications

Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.
Targets
PDGFR [1]
(Cell-free assay)
c-Kit [2]
(M-07e cells)
v-Abl [1]
(Cell-free assay)
100 nM 100 nM 600 nM
In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. [1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. [2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. [3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GIST882 NF3YO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYG5OkBp NIe0T4dKSzVyPUGuO{DPxE1? NIXvWo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFIyOid-MkS5NFAzOTJ:L3G+
K562 MmDZR5l1d3SxeHnjbZR6KEG|c3H5 NHW2dowzPCCq NEPaW5NKSzVyPUCuNlEh|ryP NX7mWmNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
MCF-7 Mmn2R5l1d3SxeHnjbZR6KEG|c3H5 NUC3TJdtOjRiaB?= NWjqUodoUUN3ME2wMlg{KM7:TR?= M3;WZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwNlA4Lz5{MkCwNFIxPzxxYU6=
MDA-MB-23 MlnvR5l1d3SxeHnjbZR6KEG|c3H5 MnrTNlQhcA>? M2XJOmlEPTB;MT64JO69VQ>? NX;wZ2YzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNFAzODdpPkKyNFAxOjB5PD;hQi=>
K562r NV[wS4tjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTFywrFOwG0> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl|OUSxPEc,OjR7M{m0NVg9N2F-
K562 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nmVmVEPTB;MD6wPUDPxE1? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ5OESxOEc,OTZ4N{i0NVQ9N2F-
MCF-7 NIjGWmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLCcoMyOCEQvF2= MnPZOFghcA>? NETBcJJjdG:la4OgZ4VtdCCycn;sbYZmemG2aX;uJIlv[3KnYYPlJIlv\HWlZXSgZpkhSkp|Wh?= M1SydFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mke0NFM1Lz5{NUK3OFA{PDxxYU6=
K-562  MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TSVGlEPTB;MTFOwG0> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ|OU[2Nkc,OjV{M{m2OlI9N2F-
K562  NIGyb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnlbYxKSzVyPUCuOeKh|ryP NVfZRZh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5N|k1OThpPkK0PVM6PDF6PD;hQi=>
PC3  MV;BdI9xfG:|aYOgRZN{[Xl? NV\hVoc4OjEkgJpOwG0> M1OyZVQ5Nzd{IHi= NITSfGFqdmO{ZXHz[ZMh[2WubDDzeZJ3cX[jbB?= NWOwe4p3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
PC3  M1;icmNmdGxiVnnhZoltcXS7IFHzd4F6 NX3MeIl2OjEkgJpOwG0> Mle2Ok04OiCq NFzkTI5qdmO{ZXHz[ZMh[2WubDD2bYFjcWyrdIm= NFnqR|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe4OlY2Pid-MkW3PFY3PTZ:L3G+
DU145 NH\QU4lCeG:ydH;zbZMhSXO|YYm= NWDX[Yx7OjEkgJpOwG0> M2DQNlQ5Nzd{IHi= M1GzN4lv\HWlZYOgZ4VtdCCmZXH0bEBjgSCjcH;weI9{cXN? NV\MdFBNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O|g3PjV4PD;hQi=>
DU145 NIK0SZlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MYKyNQKBkc7:TR?= MUW2MVczKGh? M3S5ToRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eR?= MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
Hep G2 M1S1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnCXm55UUN3ME2zNUDPxE1? NWfzU3J5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OlMzOzJpPkK1PFY{OjN{PD;hQi=>
T47D  MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP2TWM2OD13MDFOwG0> Mn3FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6NkOyN|IoRjJ3OE[zNlMzRC:jPh?=
EOL-1 NXz6fndDS3m2b4TvfIlkcXS7IHHzd4F6 NXnVcGJkPzJiaILz M3fjZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVQVC1zIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFAxOiEQvF2u MnLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
EOL-1 NGLh[IdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWrJblVQPzJiaILz NIfyZmdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXPUE0yKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gNE4xODFizszNMi=> NXHncJdSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OFQyPDlpPkK5OVQ1OTR7PD;hQi=>
GISTT1 MWLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NGruW3U4OiCqcoO= MnrURY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJSWPUWFEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlAxOyEQvF2u NVq5NW8yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
Sf9 NF;2Tm1HfW6ldHnvckBie3OjeR?= NVjRZ|lVSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBi[3SrdnWgd4l1\SCxZjDOMZRmem2rbnHsJIhmgGGqaYP0bYRqdmVvdHHn[4VlKEGETEKg[ZhxemW|c3XkJIlvKFS{aXPoc5BtfXOrYTDubUBqdm[nY4Tl[EBU\jliY3XscJMh[nliaYPveIhmem2jbDD0bZRz[XSrb36gZ4Ftd3KrbXX0dolkKGG|c3H5MEBM\CB;IECuNFA3KM7:TT6= NF;hOIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUSxO|M1Oyd-MkG0NVc{PDN:L3G+
K562 NFXidGRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NX3XWW5rSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDpcYF1cW6rYj3y[ZNqe3SjboSgT|U3OiClZXzsd{whUUN3MDC9JFAvODB4MEWg{txONg>? Mm\WQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|N{[1PFcoRjJzM{e2OVg4RC:jPh?=
GISTT1 Ml3WRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGnnSVY4OiCqcoO= NUn4cXJXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBkU0mWIHTldIVv\GWwdDDoeY1idiCJSWPUWFEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlAxQCEQvF2u MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
GISTT1 NU\nPGxkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUnZXZZvPzJiaILz NVqzUVJ4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVXDFiY3XscJMhdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvODB6IN88UU4> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1 NGH5fHhHfW6ldHnvckBie3OjeR?= NEHzbpg4OiCqcoO= MYLJcohq[mm2aX;uJI9nKEuLVDDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiR1m1NEA:KDBwMEGg{txONg>? MojzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5N{OxOVMoRjJ|N{ezNVU{RC:jPh?=
BAF3 NYD4PIk1TnWwY4Tpc44h[XO|YYm= M{G2UlczKGi{cx?= M1fzcmlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIGDES2ZT[WyyaHGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvODFyNzFOwG0v M{TueVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
TF1 MnLRR5l1d3SxeHnjbZR6KGG|c3H5 MXTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUSlEh[2WubIOg[ZhxemW|c3nu[{BkNUuLVDDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTygTWM2OCB;IECuNFE{KM7:TT6= NXTuXmhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
GIST882 Mlv1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXu3NkBpenN? NYH6d5ZMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBkU0mWIHTldIVv\GWwdDDoeY1idiCJSWPUPFgzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubITpeIVzNWeubz;DR2s5KGG|c3H5MEBIUTVyIE2gNE4xOTRizszNMi=> M4e4OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
GIST882 MoDFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWK3NkBpenN? NVK5SWt5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDHTXNVQDh{IHPlcIx{KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjBzNDFOwG0v NGqwbnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3 NWDTUnNMTnWwY4Tpc44h[XO|YYm= NE\kflc4OiCqcoO= MVfJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMEG3JO69VS5? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3 NUTueJZpTnWwY4Tpc44h[XO|YYm= MkHpO|IhcHK| NU\seJZ5UW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgVGRITlKkZYThJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJCN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6wNVkh|ryPLh?= MmLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
BAF3 NFjPN3FHfW6ldHnvckBie3OjeR?= MlLHO|IhcHK| MlTvTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiUFTHSnIu[mW2YTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBDSUZ|IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkCxPUDPxE1w NFz4RVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882 NG\HTmVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{DOWVczKGi{cx?= NGexNFlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgZ4VtdCC2aYTldk1odG9iYYPzZZktKEeLNUCgQUAxNjB{IN88UU4> NYDkVXN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
BAF3 Mn;3SpVv[3Srb36gZZN{[Xl? NVznd|VDPzJiaILz NXrxeFR5UW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgZ2tKXCCFNke0V{BufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvODJ2OTFOwG0v NVvmRVl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
BA/F3 Mo[xRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MUS0PEBpenN? NGTCbHBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KEKlcj3hZowhdmWpYYTpeoUh[2WubIOg[ZhxemW|c3nu[{BV\WxvUFTHSnJj\XSjIHvpcoF{\SCjc4Pld5Nm\CCjczDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjB{NzFOwG0v NVzvRZgzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ|PD;hQi=>
HL60 M{DvZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWK3NkBpenN? M4frOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwhe3W{dnn2ZYwh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODNizszNMi=> NWWzfINrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4OVAxODRpPkK2PFUxODB2PD;hQi=>
BAF3 MYfGeY5kfGmxbjDhd5NigQ>? MnvJO|IhcHK| NH7LUW9KdmirYnn0bY9vKG:oIHj1cYFvKHerbHSgeJlx\SCEQ2KtRWJNKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFXDOVAhRSByLkCzOEDPxE1w NX3JN2E6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVA5OTBpPkK3NFExQDFyPD;hQi=>
BA/F3 MkP6SpVv[3Srb36gZZN{[Xl? NGjZdmY4OiCqcoO= MlW3TY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJidHCqYTCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0tvODDhd5NigSxiR1m1NEA:KDBwMEO0JO69VS5? M2nrSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
BAF3 MYDGeY5kfGmxbjDhd5NigQ>? Mn\GO|IhcHK| NWDidYluUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgVGRITlJvYXzwbIEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG|c3H5MEBIUTVyIE2gNE4xOzRizszNMi=> M{K3bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BAF3 NGr1SZRHfW6ldHnvckBie3OjeR?= M2nnOlczKGi{cx?= NH7kflNKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKFZ3NUnEJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4xOzZizszNMi=> NVzEW286RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
BA/F3 M4q0dGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MXrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IGDES2ZT[mW2YTD0doFve2[nY4Tl[EBud3W|ZTDCRU9HOyClZXzsd{whUUN3MDC9JFAvODN7IN88UU4> NFvRR3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
BAF3 NITFWGJHfW6ldHnvckBie3OjeR?= M{fCRVczKGi{cx?= M2rkOGlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXjV3OVSgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMEO5JO69VS5? M3yycVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
BAF3 NVTXXpdyTnWwY4Tpc44h[XO|YYm= MY[3NkBpenN? Ml;hTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhXjV3OVSgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMEO5JO69VS5? NI\EZ3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
MDCK2 M2LNfGZ2dmO2aX;uJIF{e2G7 NWq1ZmVHPSCvaX7z MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG1CXEVzLX3l[IlifGWmIGuxOH0udWW2Zn;ycYlvKHWydHHr[UBmgHC{ZYPz[YQhcW5icH;sZZJqgmWmIF3ER2szKGOnbHzzJIFnfGW{IEWgcYlveyCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkd3WwdHnu[{BidmGueYPpd{whUUN3MDC9JFAvODRizszNMi=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
GISTT1 MlfOR5l1d3SxeHnjbZR6KGG|c3H5 NVLGOVRrPzJiaILz NX72RXMzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hT0mVVGSxJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmekeubzDhd5NigSxiR1m1NEA:KDBwMESg{txONg>? NXSyUW11RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5PVE1PjVpPkK4PVkyPDZ3PD;hQi=>
HEK293 NHLxbpRHfW6ldHnvckBie3OjeR?= NYjjcmRCUW6qaXLpeIlwdiCxZjDheZRweGixc4Doc5J6dGG2aX;uJI9nKESGUkGg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBGVEmVQTygTWM2OCB;IECuNFQ{KM7:TT6= M1XncFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO|U{QDxxYU6=
K562 NYPmNYhpTnWwY4Tpc44h[XO|YYm= M{K0V|MxKG2rboO= MX7Jcohq[mm2aX;uJI9nKGurbn;i[YFlKGKrbnTpcochfG9iTmHPNkBqdiCqdX3hckBMPTZ{IHPlcIx{KGmwY4XiZZRm\CCob4KgN|AhdWmwczDifUBqXFKDUTDy[YFo\W62LXLhd4VlKG2jc4Ogd5Bm[3S{b33leJJq[yCvZYToc4QtKEmFNUCgQUAxNjB2MzFOwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
MEG01 M{nEcmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NIfQUII4OiCqcoO= NGXZfVJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3FS|AyKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE4xPDVizszNMi=> MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BAF3 MlTuSpVv[3Srb36gZZN{[Xl? NGm1[po4OiCqcoO= NX64dYtuUW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgZ2tKXCCONUe2VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvODR3MTFOwG0v NFnSSGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
MO7e NHzJbWRHfW6ldHnvckBie3OjeR?= MkXnTY5pcWKrdHnvckBw\iCVQ1[tbY5lfWOnZDDwbI9{eGixconsZZRqd25ib3[gZ{1McXRiaX6gUW84\SClZXzsd{BjgSCWUj3GVmVVKGG|c3H5MEBKSzVyIE2gNE4xPDZizszNMi=> NXr4U5hjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFc{PzlpPkG4OFQ4Ozd7PD;hQi=>
BA/F3 MXfGeY5kfGmxbjDhd5NigQ>? NWXvUXp6PzJiaILz MXzJcohq[mm2aX;uJI9nKFSHTD3meZNm\CCSRFfGVoFteGijIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjB2NjFOwG0v Mn\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
K562 MkPFR5l1d3SxeHnjbZR6KGG|c3H5 MnKzO|IhcHK| NEXadW9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNFQ6KM7:TT6= NYn4VolxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
HEK293 M1;idGZ2dmO2aX;uJIF{e2G7 NXfVZmRKOS53IH3pcpM> MnPqTY5pcWKrdHnvckBw\iCqdX3hckBOSVSHMT3t[YRq[XSnZDDbNVReNW2ndH\vdo1qdiC3cIThb4Uh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bi\nSncjCxMlUhdWmwczDifUB{[2mwdHnscIF1cW:wIHPveY51cW6pIHHuZYx6e2m|LDDJR|UxKD1iMD6wOUDPxE1w MojzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEGwNlkoRjJ|MkSxNFI6RC:jPh?=
BA/F3 Mn:5RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIjnUZI2KHSxIEGwJJVO NH7vcWg1QCCqcoO= M{DK[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BV\WxvU1iyMWtFKGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGG2IEWgeI8hOTBidV2gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNFU2KM7:TT6= MkDVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
HT-29 MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVy5OkBpenN? MVPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiWLUK5JINmdGy|IHHmeIVzKDl4IHjyd{BjgSCVUlKgZZN{[XluIFnDOVAhRSByLkC2JO69VS5? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4OUW0O{c,OTl2Nkm1OFc9N2F-
K562 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MkLKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHluIFnDOVAhRSByLkC2JO69VS5? MlvlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NkS1NFMoRjJ4Mk[0OVA{RC:jPh?=
HT-29 Ml;iRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MofSPVYhcHK| M{nm[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSGStNlkh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IECuNFYh|ryPLh?= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTd{NE[1N{c,Ojl5MkS2OVM9N2F-
JURL-MK1 MmjoRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NIDj[oE1QCCqcoO= MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEqXUlytUWsyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvODZizszNMi=> NV3MZ|Q3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
BA/F3 MX\GeY5kfGmxbjDhd5NigQ>? NWC0UIV{PzJiaILz NHHNWldKdmirYnn0bY9vKG:oIFvpeEBXPTZyRDDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvODdizszNMi=> MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
A31 Mlu2SpVv[3Srb36gZZN{[Xl? MoHnTY5pcWKrdHnvckBw\iCSRFfGVoJmfGFiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDBN|Eh[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlA4OiEQvF2u MlPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1N|goRjJyOEG3OVM5RC:jPh?=
A31 MkXuSpVv[3Srb36gZZN{[Xl? NYXwdnJNUW6qaXLpeIlwdiCxZjDoeY1idiCSRFfGVoFteGijIHH1eI9xcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gRVMyKGOnbHzzJIJ6KEWOSWPBMEBKSzVyIE2gNE4xPzJizszNMi=> NGfkXIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
MEG01 M3vyVmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MX23NkBpenN? M{fJfGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQlPSMWFDVCCmZYDlcoRmdnRiTVXHNFEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlA4PCEQvF2u M4DveVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O|A2Lz5{N{C3O|cxPTxxYU6=
MEG01 NXWwWVN{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3\1TlczKGi{cx?= NGK2WppCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3FS|AyKGOnbHzzJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlA4PCEQvF2u MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
Ba/F3 NXXtNXdZTnWwY4Tpc44h[XO|YYm= MWi0PEBpenN? NVzvNHl5UW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDHNlUxUCCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG|ZTDhd5NigSxiR1m1NEA:KDBwMEe3NUDPxE1w NFjrOJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzO|k5OSd-M{CxN|c6QDF:L3G+
BA/F3 NGDVWZlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIXYSlE2KHSxIEGwJJVO M1LUeVQ5KGi{cx?= MlzyRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJHRmdC2VSEOtV2gzNUuGIHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHH0JFUhfG9iMUCgeW0h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODh6IN88UU4> NYrD[|RrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[0NVU5PjNpPkG2OFE2QDZ|PD;hQi=>
BA/F3 MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWXEe3Z{PDhiaILz NWnkZ2QyT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzD3bYxlNXS7cHWgRoNzNUGkbDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6wPFkh|ryPLh?= MnnBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3NkKyNVcoRjJ4NU[yNlE4RC:jPh?=
K562 NUfWV2ZCTnWwY4Tpc44h[XO|YYm= M1TyclMxKG2rboO= NV\ZepFEUW6qaXLpeIlwdiCxZjDrbY5w[mWjZDDibY5lcW6pIITvJGRFWjFiaX6gbJVu[W5iS{W2NkBk\WyuczDpcoN2[mG2ZXSg[o9zKDNyIH3pcpMh[nliaWTSRXEhemWjZ3XueE1j[XOnZDDtZZN{KHOyZXP0do9u\XS{aXOgcYV1cG:mLDDJR|UxKD1iMD6wPUDPxE1w MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
Ba/F3 NEjqUI9HfW6ldHnvckBie3OjeR?= M4TMZ|Q5KGi{cx?= Mn3HTY5pcWKrdHnvckBw\iC5aXzkJJR6eGViQlPSMWFDVDFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQnGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IFLybZRmVGmpaISgcJVkcW[ncnHz[UBie3OjeTygS2k2OCB;IECuNFkxPSEQvF2u MoK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
BA/F3 MkPuR5l1d3SxeHnjbZR6KGG|c3H5 M3vNbVQ5KGi{cx?= M2rDVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghf2muZDD0fZBmKEKlcj3BZowh[W[2ZYKgOFghcHK|IHL5JHhVXCCjc4PhfUwhUUN3MDC9JFAvODl{IN88UU4> NGnVTHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[wNFgxPid-MkO2NFA5ODZ:L3G+
GIST882 MkewSpVv[3Srb36gZZN{[Xl? NXHBRWhkUW6qaXLpeIlwdiCxZjDoeY1idiCNSWSgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBIUVOWOEiyJINmdGy|IHL5JGVNUVODLDDJR|UxKD1iMD6wPVch|ryPLh?= NUPmNlhYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882 MmDhSpVv[3Srb36gZZN{[Xl? NF[1VWhKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiYYX0c5Bpd3OyaH;yfYxifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGK7IFXMTXNCNCCLQ{WwJF0hOC5yOUeg{txONg>? NULsVnloRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
insect NUnhXIxZTnWwY4Tpc44h[XO|YYm= NFHOS2Y{OCCvaX7z MkPUTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v Ml;JQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
K562 M2SxRWN6fG:2b4jpZ4l1gSCjc4PhfS=> MXW3NkBpenN? NFLJS|REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IECuNUDPxE1w MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
primary leukemia cells M2XIRWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3nxfVczKGi{cx?= MkH6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJqdWG{eTDs[ZVs\W2rYTDj[YxteyCrc3;sZZRm\CCocn;tJIFkfXSnIH35[YxwcWRibHX1b4VucWFicHH0bYVvfCCneIDy[ZN{cW6pIIfpcIQhfHmyZTDGUHQ{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBtfWOrZnXyZZNmKGG|c3H5MEBKSzVyIE2gNE4yKM7:TT6= NI\VNY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BV173 NFLadolCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWjGToJzPDhiaILz NHjPZmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLWNVc{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvOSEQvF2u MoWwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyMUGxOVkoRjJ5MEGxNVU6RC:jPh?=
BAF3 M3G2dGZ2dmO2aX;uJIF{e2G7 MmXGO|IhcHK| M4XxdmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhVDV4N2CgcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIx1cXSncj3ncI8wS0ONODDhd5NigSxiR1m1NEA:KDBwMTFOwG0v NFGxW4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
K562 MkXJR5l1d3SxeHnjbZR6KGG|c3H5 MkjBNlQhcHK| M2TCc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOSEQvF2u M2Xh[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkOyPVM2Lz5{Mk[zNlk{PTxxYU6=
BA/F3 MnLQSpVv[3Srb36gZZN{[Xl? NVX4fZViPzJiaILz NXPxcGF1UW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgVGRITlKkZYThJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkGwNkDPxE1w MkLLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BAF3 NH\4bZZHfW6ldHnvckBie3OjeR?= MYK3NkBpenN? MnTSTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhVDV5NmCgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMUCyJO69VS5? M{\KWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 NGXVVlVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmmxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJSWPUPFgzKGOnbHzzMEBKSzVyIE2gNE4yODhizszNMi=> NX;JXnpXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882 NXPJNVRXTnWwY4Tpc44h[XO|YYm= NX\NVHJ7UW6qaXLpeIlwdiCxZjDLTXQhUzZ2MlWgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEBoem:5dHigbY5pcWKrdHnvckBjgSCDVGCt[IVxdGW2aX;uJIF{e2G7LDDJR|UxKD1iMD6xNFgh|ryPLh?= NYHoT4t1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
K562 NWW1[lZqS3m2b4TvfIlkcXS7IHHzd4F6 MmDPR5l1d3SxeHnjJIVn\mWldDDpckBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zMTFOwG0v MnHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ7NUGxNVMoRjF{OUWxNVE{RC:jPh?=
KU812 NHjte4JCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVXXbHNUPzJiaILz M4\CSWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCwMlEyKM7:TT6= Mme1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3 Mn3ERY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{H6dVczKGi{cx?= NUC5b|RoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhUDN7NmCgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuNVEh|ryPLh?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
BAF3 NFPhTINHfW6ldHnvckBie3OjeR?= MmjmO|IhcHK| M{f3NWlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIFPTSlFTKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44hdWWjc4Xy[YQh[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTFizszNMi=> NHPwe5U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
32D M{SwW2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWDJUG0{PDhiaILz M3POZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViM{LEJINmdGy|IITyZY5{\mWldHXkJJdqfGhicEKxNEBk\WyuczDlfJBz\XO|aX7nJGJkei2jYnygZZN{\XO|ZXSgZZMheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6xNVIh|ryPLh?= M{j3[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
insect cells NF\BdVBHfW6ldHnvckBie3OjeR?= MVKzNEBucW6| NUmxVFQ2UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKE1|NUHUJI12fGGwdDDlfJBz\XO|ZXSgbY4hcW6|ZXP0JINmdGy|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuNVE1OyEQvF2u NXHY[|NGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
insect cells M3:1e2Z2dmO2aX;uJIF{e2G7 NGTFfZI{OCCvaX7z NHTPVI1KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhWTJ3MligcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR|UxKD1iMD6xNVUh|ryPLh?= Mm\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
K562 NFmxfY9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnHOO|IhcHK| MoXmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDCR3IuSUKOIHTldIVv\GWwdDDoeY1idiCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6xNkDPxE1w MlTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BA/F3 MlfKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MmrqO|IhcHK| MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNUGkbDDNNlQ1XiCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC5zMkmg{txONg>? MlzOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
K562 M3XiUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MnrhO|IhcHK| MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONLUigZZN{[XluIFfJOVAhRSByLkG0JO69VS5? MofDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
HEK293 MXPGeY5kfGmxbjDhd5NigQ>? MkXaTY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJGRFWjJiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMUSxJO69VS5? NF\KbHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
K562 M2nwZmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHnmRWM4OiCqcoO= MnH4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xOFch|ryPLh?= M{XYeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
BAF3 MWDGeY5kfGmxbjDhd5NigQ>? NGHlPIQ4OiCqcoO= NYPW[ZNIUW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgZ2tKXCCDOEK5VEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvOTR6MjFOwG0v MkP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
Ba/F3 NVz3WHVJTnWwY4Tpc44h[XO|YYm= MVG0PEBpenN? M3e4RmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRUO1OWchdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjF2OTFOwG0v MkHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
KU812 NXzLU5NwSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M{j3TVczKGi{cx?= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEuXOEGyJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6xOkDPxE1w MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
KU812 NHHqeIpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NELvT4U4OiCqcoO= NU\aZW5TSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMJIRmeGWwZHXueEBpfW2jbjDLWVgyOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFAvOTZizszNMi=> NX;abI9SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO|c4ODVpPkK3NFc4PzB3PD;hQi=>
A10 Mm\2SpVv[3Srb36gZZN{[Xl? NUXXS2JWPjhiaILz MYTJcohq[mm2aX;uJI9nKFCGR1\SMYJmfGFiZILpeoVvKHC{b3zp[oVz[XSrb36gc4YhemG2IFGxNEBk\WyuczDh[pRmeiB4ODDodpMhcW5icILld4Vv[2Vib3[gdoF1KHKnY3;tZolv[W62IGDES2YuSkJiYomgZ4VtdCC2aYTldk1odG9ibIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMD6xOlIh|ryPLh?= M{jYfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NUCyO|AxLz5{N{WwNlcxODxxYU6=
KU812 MojnRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUjLSodDPzJiaILz NX7hZXVtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLWVgyOiClZXzsd{Bu\WG|dYLl[EBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2s5KGG|c3H5MEBIUTVyIE2gNE4yPjNizszNMi=> NIfKdZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
K562 MXLDfZRwfG:6aXPpeJkh[XO|YYm= Mn7oR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{whUUN3MDC9JFAvOTdizszNMi=> M{HiTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkCwPFA3Lz5{M{[wNFgxPjxxYU6=
K562 MYrBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYnsWnJSSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBIUTVyIE2gNE4yPyEQvF2u MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR|OU[3OEc,OjJ2M{m2O|Q9N2F-
insect cells NGrEO2tHfW6ldHnvckBie3OjeR?= MW[zNEBucW6| MW\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgTFM6PlBibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hOC5zN{O5JO69VS5? M3zJZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
K562 M3TDdWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmfCR5l1d3SxeHnjbZR6KGGpYXnud5QhUzV4MjDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE5KM7:TT6= M3TYcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUeyNFg5Lz5zN{W3NlA5QDxxYU6=
K562 M3HGVGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYX5V5A1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zOEKg{txONg>? NUH3[4N3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zN|I1PDBpPkG2N|MzPDRyPD;hQi=>
32D NIHvW2ZEgXSxdH;4bYNqfHliYYPzZZk> MXTDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDtc5V{\SB|MlSgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCyMkGwJGJkei2jYnysJGlEPTBiPTCwMlE6KM7:TT6= MoTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
BA/F3 NH\wSIhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NV7WXJplPDhiaILz M{P2bWFvfGmycn;sbYZmemG2aX;uJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvYXLsJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE6KM7:TT6= NGC5b4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
BA/F3 NH3nWVFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVW0PEBpenN? MkPJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAhSmO{LXHicEBie3Onc4Pl[EBieyCycn;sbYZmemG2aX;uJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlE6KM7:TT6= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
BA/F3 MnHESpVv[3Srb36gZZN{[Xl? NIHNUIE4OiCqcoO= MXHJcohq[mm2aX;uJI9nKEurdDDlfI9vKDliQWm1NFIhfG9iNUCzJIlve2W{dHnvckBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMUmyJO69VS5? Mk\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
32D MWnGeY5kfGmxbjDhd5NigQ>? NW\x[Ix4UW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SB|MlSgZ4VtdHNuIFnDOVAhRSByLkG5OEDPxE1w NIPLc3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xNVc4OSd-MkO2NVE4PzF:L3G+
K562 NFPFfY9CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Mof6OFghcHK| MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOnbHytWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDHTVUxKD1iMD6yJO69VS5? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
Ba/F3 M3H6RmZ2dmO2aX;uJIF{e2G7 MVm0PEBpenN? M{f3RWlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRUS1PWshdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjJyMTFOwG0v NHfBRYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzO|k5OSd-M{CxN|c6QDF:L3G+
BA/F3 NVS4NZlZTnWwY4Tpc44h[XO|YYm= MoDwO|IhcHK| MlzUTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIFS4NlBCKG23dHHueEBidmRiREiyNGEhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkKxOkDPxE1w NWLS[m1WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
Sf9 NFrLbJBHfW6ldHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGx6diCtaX7hd4Uh\XiycnXzd4VlKGmwIGPmPUBk\WyuczygTWM2OCB;IECuNlIh|ryPLh?= M4LYVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{e2OlgxLz5zN{O3OlY5ODxxYU6=
K562 NYG3[49DSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlvKOFghcHK| NWTFTZh4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTD0dplx[W5iYnz1[UBlgWViZYjjcJV{cW:wIHHzd4F6NCCLQ{WwJF0hOC5{MjFOwG0v Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4Mkm4OVkoRjJ4NkK5PFU6RC:jPh?=
Ba/F NYWwbnpJTnWwY4Tpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGG3dH;wbI9{eGixconsZZRqd25ib3[gRmNTNUGETEGg[ZhxemW|c3XkJIlvKEKjL1[gZ4VtdHNuIFnDOVAhRSByLkKyNUDPxE1w NHT4NYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
BA/F3 M1rCZ2Z2dmO2aX;uJIF{e2G7 NWW5WFVKUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KtRWJNOSCjdYTvdIhwe3Cqb4L5cIF1cW:wIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{BjgSCHTFnTRUwhUUN3MDC9JFAvOjJzIN88UU4> M3i4O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NkGxO|cyLz5{M{[xNVc4OTxxYU6=
BA/F3 MnO2SpVv[3Srb36gZZN{[Xl? MoTVO|IhcHK| MXXJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiTkiyNmshdXW2YX70JIFv\CC\OEKzSEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwMkKzJO69VS5? M372WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
SF9 MYXGeY5kfGmxbjDhd5NigQ>? NGLBSFMyKGi{ NFmwe|VKdmirYnn0bY9vKG:oIFOteIVzdWmwYXygTIl{NXSjZ3fl[EBpfW2jbjDBRmwyKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBUTjliY3XscJMhfXOrbnegWJlzKDB{IIDldJRq\GViYYOgd5Vje3S{YYTlJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliRmLFWEBj[XOnZDDaK2x6fGViYYPzZZktKEmFNUCgQUAxNjJ{MzFOwG0v MnzHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
NCI-H1703 NVrEc3FVSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NICzNI04OiCqcoO= NWnBSpU6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDF5MEOgZ4VtdHNiYX\0[ZIhPzJiaILzJIlvKHC{ZYPlcoNmKG:oIGDES2YuSUFiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFAvOjNizszNMi=> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
CHO NF3ZZZRHfW6ldHnvckBie3OjeR?= M{n6T2lvcGmkaYTpc44hd2Zid3ns[EB1gXCnIGDsZZRmdGW2LXTldol3\WRiZ4Lve5RpKG[jY4TvdkBz\WOncITvdkBj\XSjIIDoc5NxcG:{eXzheIlwdiCrbjDDTG8h[2WubIOsJGlEPTBiPTCwMlI1KM7:TT6= MnznQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJzNk[5OVAoRjF{MU[2PVUxRC:jPh?=
MEG01 NG\tenhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWe3NkBpenN? M2q4c2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVXHNFEh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTCwMlI1KM7:TT6= M13nVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
BA/F3 MXLDfZRwfG:6aXPpeJkh[XO|YYm= MofUO|IhcHK| NE\ZXVNEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiTUO1NXQhdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwMkSg{txONg>? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
K562 M3G2WmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXq0NYw6SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE4zPDRizszNMi=> M{TjVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO|U{QDxxYU6=
Ba/F3 NUjqOppwTnWwY4Tpc44h[XO|YYm= NUH0bYVtPDhiaILz M3vIT2lvcGmkaYTpc44hd2ZiQlPSMWFDVDFiRkO1PXYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjJ2OTFOwG0v NXrOZ2tCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|c6QDFpPkOwNVM4QThzPD;hQi=>
K562 NFvINplHfW6ldHnvckBie3OjeR?= M1rke|MxKG2rboO= NVfvS2VsUW6qaXLpeIlwdiCxZjDrbY5w[mWjZDDibY5lcW6pIITvJGFDVCCrbjDoeY1idiCNNU[yJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOzBibXnud{BjgSCrVGLBVUBz\WGpZX70MYJie2WmIH3hd5Mhe3CnY4Tyc41mfHKrYzDt[ZRpd2RuIFnDOVAhRSByLkK1JO69VS5? MkG1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OECyOlEoRjJ6MkiwNlYyRC:jPh?=
M07e M{WybGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGjsTIQ1QCCqcoO= NIDvdFVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF2wO4UhSmO{LXHicEBv\WejdHn2[UBk\WyuczDlfJBz\XO|aX7nJJN1\W1iY3XscEBn[WO2b4KgZZN{\XO|ZXSgZZMheHKxbHnm[ZJifGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD6yOVch|ryPLh?= NHfjeZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
CHO M1juS2Z2dmO2aX;uJIF{e2G7 MorrTY5pcWKrdHnvckBw\iClaHnt[ZJq[yCSRFfGJJJm[2WydH;yJJdqfGhiYz3rbZQh[3m2b4DsZZNucWNiZH;tZYlvKHCqb4PwbI9zgWyjdHnvckBqdiCFSF:gZ4VtdHNuIFnDOVAhRSByLkK2JO69VS5? Mkn3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJzNk[5OVAoRjF{MU[2PVUxRC:jPh?=
EM2 M4HWc2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 NV\GZ2p{PDhiaILz MnL6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCHTUKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KEOnbHytWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDHTVUxKD1iMD6yOkDPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
K562 Ml;URY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MlrjO|IhcHK| MnHkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IH3lZZN2emWmIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFS{igZZN{[XluIFfJOVAhRSByLkK2O{DPxE1w NUT1fFM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
BAF3 MX\GeY5kfGmxbjDhd5NigQ>? MXS3NkBpenN? NYLvSlQ3UW6qaXLpeIlwdiCxZjDoeY1idiCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDBwMkeg{txONg>? NIXS[449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
K562 NGr0TWxHfW6ldHnvckBie3OjeR?= NV33U|BZOzBibXnudy=> NEfP[YhKdmirYnn0bY9vKG:oIHvpco9j\WGmIHLpcoRqdmdidH:gRXJIKGmwIHj1cYFvKEt3NkKgZ4VtdHNiaX7jeYJifGWmIH\vdkA{OCCvaX7zJIJ6KGmWUlHRJJJm[WenboStZoF{\WRibXHzd{B{eGWldILvcYV1emmlIH3leIhw\CxiSVO1NEA:KDBwMkeyJO69VS5? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
KBM5 M1jkUWN6fG:2b4jpZ4l1gSCjc4PhfS=> MmX4O|IhcHK| MWjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRm02KGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSmO{LVHicEBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4zQCEQvF2u MonrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEm2OlUoRjJyMUS5OlY2RC:jPh?=
K562 M{TUNWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NGLkeFI4OiCqcoO= MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiZYjwdoV{e2mwZzD3bYxlKHS7cHWgRoNzNUGkbDDh[pRmeiB5MjDodpMh[nliQ1PLMVgh[XO|YYmsJGlEPTBiPTCwMlI5KM7:TT6= NWXWcnJKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xPVUyOzZpPkK2NVk2OTN4PD;hQi=>
HEK293 MWnGeY5kfGmxbjDhd5NigQ>? Mon6TY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJGNUTjGUIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkK5NUDPxE1w NXq3eYVmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
Sf9 MnrVSpVv[3Srb36gZZN{[Xl? M1K3eWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgRYJtKGurbnHz[UApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNidYPpcochT0eHQVnZRWFRTkuNIHHzJJN2[nO2cnH0[UBqdiCycnXz[Y5k\SCxZjDb[4FudWF|M2DdRXRRNCCLQ{WwJF0hOC5|IN88UU4> MnzGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
K562 M1XteWN6fG:2b4jpZ4l1gSCjc4PhfS=> MlfTO|IhcHK| Mn7nR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiN{KgbJJ{KGK7IGjUWEBie3OjeTygTWM2OCB;IECuN|Eh|ryPLh?= NUi3[INuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyNVQ2OTJpPkK3NlE1PTF{PD;hQi=>
BA/F3 NUnX[3c4TnWwY4Tpc44h[XO|YYm= NWHCSYg4PzJiaILz MV7Jcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiQUiyPXAhdXW2YX70JIFv\CC\OEKzSEBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwM{GyJO69VS5? M2ezd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
ALL3 NVvmPVBbS3m2b4TvfIlkcXS7IHHzd4F6 NGDrXHpEgXSxdH;4bYNqfHliYXfhbY5{fCCSaHnsZYRmdHCqaXGgZ4hzd22xc3;t[UBxd3OrdHn2[UBpfW2jbjDBUGw{KGOnbHzzJIJ6KEGuYX3hdkBDdHWnIH\seY9z\XOlZX70JIF{e2G7LDDJR|UxKD1iMD6zN|Mh|ryPLh?= NVrIO|FrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PFk2PDBpPkG5PFg6PTRyPD;hQi=>
KU812 NU\oW4N4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3PsZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOsJGlEPTBiPTCwMlM{PyEQvF2u NGD2NYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO3OlU5Pyd-MkGzO|Y2QDd:L3G+
BA/F3 MYDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1i3Z|Q5KGi{cx?= NID3WZZCdnSrcILvcIln\XKjdHnvckBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LXHicEBCOzN5TjDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwM{O5JO69VS5? M3zKUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
CML MoezRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NEO5[4VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPNUEBk\WyuczygTWM2OCB;IECuN|Uh|ryPLh?= M1XsN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MkG5NFE3Lz5zOUKxPVAyPjxxYU6=
HEK293 MXXGeY5kfGmxbjDhd5NigQ>? MX6xMlUhdWmwcx?= NVL5cIozUW6qaXLpeIlwdiCxZjDoeY1idiCPQWTFNmsudWWmaXH0[YQhSVOSKzD1dJRic2ViZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyC3cDD0c{A2ODBidV2gZYZ1\XJiMT61JI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4{PSEQvF2u MnfrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NEGwNlkoRjJ|MkSxNFI6RC:jPh?=
HEK293 NFnGbnlHfW6ldHnvckBie3OjeR?= MlfhNU42KG2rboO= NWHBelN{UW6qaXLpeIlwdiCxZjDoeY1idiCPQWTFNU1u\WSrYYTl[EBCW1BtIIXweIFs\SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFEvPSCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NEA:KDBwM{Wg{txONg>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
M-NFS-60 NX\wTpVjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHPISJdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIF2tUmZUNTZyIHPlcIx{NCCLQ{WwJF0hOC5|NUig{txONg>? NIPObJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|U{QCd-MkC4NVc2Ozh:L3G+
insect cells M1HQ[2Z2dmO2aX;uJIF{e2G7 MV6zNEBucW6| MmLHTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJGczPTCHIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwM{W5PUDPxE1w MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
BA/F3 NUPZNol6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEjmcWU4OiCqcoO= NXvacFdjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTTN3NVegcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IECuN|YzKM7:TT6= NViwS3Z6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3 MnK3SpVv[3Srb36gZZN{[Xl? NVXGSZVsPzJiaILz NVLXWnVpUW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgZ{1MUVRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjN5IN88UU4> NF;yTJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0OFE1QSd-Mkm1OFQyPDl:L3G+
BAF3 MnTKSpVv[3Srb36gZZN{[Xl? NFzOVoZKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjMWtKXCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjN5IN88UU4> NUi2VmdbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
K562 MXjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVAhRSByLkO4JO69VS5? MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN5NkW4O{c,OjF|N{[1PFc9N2F-
K562 NHjQR2ZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnvTO|IhcHK| NWLWe2IzSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCC|dYL2bZZidCCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5|ODFOwG0v NGPPUZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nki1NFAxPCd-Mk[4OVAxODR:L3G+
BA/F3 M4PH[mZ2dmO2aX;uJIF{e2G7 M{LH[FczKGi{cx?= MYjJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0tvODDhd5NigSxiR1m1NEA:KDBwM{ig{txONg>? NGT1Slc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BAF3 NFrxWlVHfW6ldHnvckBie3OjeR?= M{HmelczKGi{cx?= NVT1NVh6UW6qaXLpeIlwdiCxZjDUSWwu\nW|ZXSgZ2tKXCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6zPFE6KM7:TT6= NFzHVZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
K562 M3zGSWN6fG:2b4jpZ4l1gSCjc4PhfS=> NUDUe5pGPDhidH:gO|IhcHK| NHPNNmtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBDS1JvQVLMJJBwe2m2aY\lJGs2PjJiY3XscJMh[W[2ZYKgOFghfG9iN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuN|g1PCEQvF2u MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd6OUSyPUc,OjJ5OEm0Nlk9N2F-
K562 NVvGUHIzS3m2b4TvfIlkcXS7IHHzd4F6 NV\YVIZoPzJiaILz MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlM6KM7:TT6= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl|MkOxN{c,OjJ7M{KzNVM9N2F-
BA/F3 MU\GeY5kfGmxbjDhd5NigQ>? NHnFcFY4OiCqcoO= Mo\hTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiBzMTDk[YxmfGmxbjCoOVU4KHSxIEW1PEBz\XOrZIXld{kh[W6mIG[2OVRCKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD6zPVIh|ryPLh?= MkniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
BA/F3 MW\BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVe1JJRwKDFyIIXN MYC0PEBpenN? NFSyW|lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochVlCPLXHicEBie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBifCB3IITvJFExKHWPIHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkO5N{DPxE1w MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjRzNUi2N{c,OTZ2MUW4OlM9N2F-
K562 Mm\MSpVv[3Srb36gZZN{[Xl? MlryTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOg[5Jwf3SqIIXzbY5oKE2WVDDhd5NigSxiSVO1NEA:KDBwNDFOwG0v Ml\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3NUK3OlAoRjF2NUWyO|YxRC:jPh?=
BAF3 NFzoN4NHfW6ldHnvckBie3OjeR?= NEn0[Hg4OiCqcoO= MoD1TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTCwMlQh|ryPLh?= NIXoUI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O|cxPSd-MkewO|c4ODV:L3G+
BA/F3 M2TFO2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 M2n2OlczKGi{cx?= MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNUGkbDDNN|UyXCCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC52MkSg{txONg>? M2HveFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
KCL22 NGXMc2FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NH3ZbJQ1QCCqcoO= NFTIS|lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFvDUFIzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvPDNizszNMi=> NF\zZ4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{CxNVE2QSd-MkewNVEyPTl:L3G+
Ba/F3 M2\LO2Z2dmO2aX;uJIF{e2G7 Mlr3OFghcHK| M{DRUGlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiUUK1NmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjR3NTFOwG0v NGDleIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzO|k5OSd-M{CxN|c6QDF:L3G+
Sf9 MY\GeY5kfGmxbjDhd5NigQ>? Mk\oTY5pcWKrdHnvckBw\iCqdX3hckBC[mxia3nuZZNmKGW6cILld5Nm\CCrbjDT[lkh[2WubIOsJGlEPTBiPTCwMlQ4KM7:TT6= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzN5Nk[4NEc,OTd|N{[2PFA9N2F-
K562 NFjC[|REgXSxdH;4bYNqfHliYYPzZZk> MknQOFghcHK| NYP5RYRIS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD60O{DPxE1w M1fmTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{O1PFI3Lz5{M{ezOVgzPjxxYU6=
K562 M1f3OmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MoPFOFghcHK| MkHjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkS3JO69VS5? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEe2Okc,OjV5N{i3OlY9N2F-
K562 M3j6TGZ2dmO2aX;uJIF{e2G7 MVvJcohq[mm2aX;uJI9nKEKFUj3BRmwyKGG3dH;wbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczygTWM2OCB;IECuOFc{KM7:TT6= M3jRWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEG3OVM5Lz5{MEixO|U{QDxxYU6=
insect cells MmrLSpVv[3Srb36gZZN{[Xl? NIr3XY8{OCCvaX7z NVfL[m9TUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDBRmwyKEV{NUXLJI12fGGwdDDlfJBz\XO|ZXSgbY4hcW6|ZXP0JINmdGy|IHHmeIVzKDNyIH3pcpMh[nliRmLFWEBie3OjeTygTWM2OCB;IECuOFg2QCEQvF2u MlH3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
Sf9 MX7GeY5kfGmxbjDhd5NigQ>? MWHCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlcY91\SC|aYTlJI9nKE5vdHXycYlv[WxiaHX4ZYhqe3SrZHnu[U11[WepZXSgRWJNOiCneIDy[ZN{\WRiaX6gWJJq[2ixcHz1d4liKG6rIHnu[oVkfGWmIGPmPUBk\WyuczDifUBqe2:2aHXycYFtKHSrdILheIlwdiClYXzvdolu\XS{aXOgZZN{[XluIFvkJF0hOC53IN88UU4> MlLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2MUezOFMoRjJzNEG3N|Q{RC:jPh?=
primary leukemia cells MmL0R5l1d3SxeHnjbZR6KGG|c3H5 NWm5TlN4PzJiaILz NUjoWHE2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4heHKrbXHyfUBt\XWtZX3pZUBk\WyuczDpd49t[XSnZDDmdo9uKGGldYTlJI16\WyxaXSgcIV2c2WvaXGgdIF1cWWwdDDlfJBz\XO|aX7nJGZNXDNvREizOXkhdXW2YYTpc44h[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JIx2[2moZYLhd4Uh[XO|YYmsJGlEPTBiPTCwMlUh|ryPLh?= NF:0TY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyNVIxOSd-MkKyNlEzODF:L3G+
BA/F3 NXPzfm4{TnWwY4Tpc44h[XO|YYm= NGLCdoE4OiCqcoO= NEjhbnlKdmirYnn0bY9vKG:oIGTFUE1NS0tiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjVizszNMi=> Ml7qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
K562 NFvyWmZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlfNRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|LDDJR|UxKD1iMD61JO69VS5? NXOzWIxLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzOVI1QDNpPkKzN|UzPDh|PD;hQi=>
K562 MlfTR5l1d3SxeHnjbZR6KGG|c3H5 NFvLNo04OiCqcoO= MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjZYxk\WmwLVHNJIF{e2G7LDDJR|UxKD1iMD61JO69VS5? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6MUWzNkc,OjN7OEG1N|I9N2F-
K562 M1XxN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUm3NkBpenN? MXnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyC3c3nu[{BE[WylZXnuJGFOKGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OCB;IECuOUDPxE1w NH3uUIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe1O|YxOyd-MkW3OVc3ODN:L3G+
K562 Mnf1R5l1d3SxeHnjbZR6KGG|c3H5 M2DzWmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMtKEmFNUCgQUAxNjVizszNMi=> NUO0[FBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexPFk3PzRpPkK3NVg6Pjd2PD;hQi=>
BA/F3 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NFjHNJM4OiCqcoO= M3;RbGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5Nqdmdid3ns[EB1gXCnIFLDVk1CSkxiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gNE42KM7:TT6= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
K562 NGS5PJNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnG2OFghcHK| M{\KcWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD61JO69VS5? M{jXfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUOyNFcyLz5{M{mzNlA4OTxxYU6=
Sf9 NF3vN2dHfW6ldHnvckBie3OjeR?= MWTUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgbY4hSkOUUD3lfJBz\XO|aX7nJHNnQSClZXzsd{whUUN3MDC9JFAvPSEQvF2u M1HsN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562 MoPWR5l1d3SxeHnjbZR6KGG|c3H5 M324c|czKGi{cx?= MkfUR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE42OSEQvF2u MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjhzNEi5NEc,OjZ6MUS4PVA9N2F-
K562 M2LnemN6fG:2b4jpZ4l1gSCjc4PhfS=> M3;UWVQ5KGi{cx?= M2XMUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPTNizszNMi=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjdyN{i0Okc,OjZ5MEe4OFY9N2F-
K562 NYnVbFk1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1nLRlQ5KGi{cx?= NUjPXG1zSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlU{KM7:TT6= M{m0TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUK1PFM5Lz5{OEWyOVg{QDxxYU6=
BA/F3 M1fpTmZ2dmO2aX;uJIF{e2G7 NWHrTJNZPzJiaILz MWPJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OVchfG9iNUW4JJJme2mmdXXzLUBidmRiREixOmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkWzOUDPxE1w M1XjUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
BA/F3 NEPVUY5HfW6ldHnvckBie3OjeR?= NUjPV|FzPzJiaILz NYnCbo9KUW6qaXLpeIlwdiCxZjDQSGdHWmGucHjhJHY2PjGGL1S4OFJXKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMD61Olch|ryPLh?= M4LCZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
K562 NVO2[45RS3m2b4TvfIlkcXS7IHHzd4F6 MYi0PEBpenN? NW[xWYxLS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC53ODFOwG0v NEHyVIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5OVM5OCd-MkGyPVU{QDB:L3G+
BA/F3 MmT3R5l1d3SxeHnjbZR6KGG|c3H5 MX:3NkBpenN? MX;DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKFUj3BRmwhTTN3OW[gcZV1[W62IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFAvPTlizszNMi=> M1KyclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3 NGntTXNHfW6ldHnvckBie3OjeR?= M{DYfVczKGi{cx?= NEHEWI9KdmirYnn0bY9vKG:oIFLDVk9CSkxicEKxNE1OOzVzVDDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGyWaYTldk1IdG9ib4KgR2NMNThiYYPzZZktKEeLNUCgQUAxNjZ{NTFOwG0v MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
BAF3 MVPGeY5kfGmxbjDhd5NigQ>? MnXOO|IhcHK| M1LrbGlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwJIZ2e2mxbjDwdo91\WmwIF2zOVZVKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCEQV[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlYzPSEQvF2u Mk\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BA/F3 NWDpW3lITnWwY4Tpc44h[XO|YYm= NF:2T|g4OiCqcoO= MnrGTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCtVVI2OkhibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gNE43PTlizszNMi=> MnLGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BA/F3 M4fNfWZ2dmO2aX;uJIF{e2G7 NEDwRms4OiCqcoO= NH;YTlJKdmirYnn0bY9vKG:oIFvpeEBmgG:wIEGxJIRmdGW2aX;uJEg2PTdidH:gOVU5KHKnc3nkeYV{MSCjbnSgXVgzO0RibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlGvSlMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDj[YxtKGe{b4f0bEBqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDNWHMh[XO|YYmsJGdKPTBiPTCwMlY3QSEQvF2u NIT5VII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3 MWfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NX:1eodQSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBDS1JvQVLMNUB1emGwc3\lZ5Rm\CCvb4Xz[UBDSS:IMzDj[YxteyxiSVO1NEA:KDBwNke4JO69VS5? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N|g9N2F-
BA/F3 MUjGeY5kfGmxbjDhd5NigQ>? Mlz6TY5pcWKrdHnvckBw\iCqdX3hckBDS1JvQVLMNUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDBWHAu\GWybHX0bY9vKGG|c3H5MEBKSzVyIE2gNE43PzhizszNMi=> NYnXVnc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
K562 Mk\nRZBweHSxc3nzJIF{e2G7 NUHLOVEyPDhiaILz NI[zWlRKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHHucoV5cW6YIHHu[EBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nJIJie2WmIH\sc5ch[3m2b33leJJ6NCCDQ{WwJF0hOC54ODFOwG0v NVrBPItHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2Nlk5PTlpPkK2OlI6QDV7PD;hQi=>
BA/F3 MoK3SpVv[3Srb36gZZN{[Xl? MofNO|IhcHK| MX7Jcohq[mm2aX;uJI9nKEurdDDWOVYxTC:YNkW0RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDBwN{CxJO69VS5? MmnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB{MES0OFEoRjNyMkC0OFQyRC:jPh?=
K562 Mn73R5l1d3SxeHnjbZR6KGG|c3H5 Mo\DO|IhcHK| NXG2Unk5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh\my3b4Lld4NmdmOnIH3pZ5JweGyjdHWgdoVi\GW{IH3leIhw\CxiSVO1NEA:KDBwN{Og{txONg>? NUXOZXprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3OFE5PTNpPkK2O|QyQDV|PD;hQi=>
BAF3 M4r3emZ2dmO2aX;uJIF{e2G7 NIO3XpY4OiCqcoO= MoLhTY5pcWKrdHnvckBw\iCDQlygbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwN{Og{txONg>? M3TKbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUe0N|M5Lz5{OEm3OFM{QDxxYU6=
insect cells NYPJU4ZrTnWwY4Tpc44h[XO|YYm= NEHycJI{OCCvaX7z NFPkUXhKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhYTJ3M1[gcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR|UxKD1iMD63OFk3KM7:TT6= NVPqXYl[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
K562 MmLDSpVv[3Srb36gZZN{[Xl? NGT3R4szKGi{cx?= MoT1TY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFIhcHK|IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqeyxiSVO1NEA:KDBwN{Wg{txONg>? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF6OEW3PUc,OjBzOEi1O|k9N2F-
BAF3 MlPlSpVv[3Srb36gZZN{[Xl? M{LDe|czKGi{cx?= MVrJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJHY2PTmGL2[2OVRCKGSxdXLs[UBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRmFHOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtKHSrdHXyMYdtdyCjc4PhfUwhT0l3MDC9JFAvQDB|IN88UU4> MnjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BAF3 NE[wXmVHfW6ldHnvckBie3OjeR?= MmXZO|IhcHK| NIHPSnhKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKFZ4NUTBJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNE45ODNzIN88UU4> M4L1U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NUSxOlk2Lz5{OEW0NVY6PTxxYU6=
Ba/F3 M2mxfmZ2dmO2aX;uJIF{e2G7 NFPEcXk1QCCqcoO= MYXJcohq[mm2aX;uJI9nKEKFUj3BRmwyKFl{NUPIJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCZU9HOyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGJEWi2DQlyxMY1m\GmjdHXkJINmdGxicILvcIln\XKjdHnvckBi\nSncjC0PEBpenNiYomgRpJqfGWOaXfoeEBtfWOrZnXyZZNmKGG|c3H5MEBIUTVyIE2gNE45OzZizszNMi=> NX7YfotyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|c6QDFpPkOwNVM4QThzPD;hQi=>
Ba/F3 M3XhUGZ2dmO2aX;uJIF{e2G7 NVXTR29xPDhiaILz NWLk[oNbUW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDFNlU2UyCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG|ZTDhd5NigSxiR1m1NEA:KDBwOEO4JO69VS5? NUL4eolrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxN|c6QDFpPkOwNVM4QThzPD;hQi=>
BAF3 MX\GeY5kfGmxbjDhd5NigQ>? NWjUPFJVPzJiaILz M{nOSWlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwJIZ2e2mxbjDwdo91\WmwIF[zNVdKKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCEQV[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCwMlg2KM7:TT6= NWX6cGFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
BA/F3 NVvIdWRzTnWwY4Tpc44h[XO|YYm= MXq3NkBpenN? MWPJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3GN|E4USCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTCwMlg2PSEQvF2u NVXkTWZLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
Ba/F3 NUTRO|M3TnWwY4Tpc44h[XO|YYm= M3OzXFQ5KGi{cx?= MlXjTY5pcWKrdHnvckBw\iCEQ2KtRWJNOSCHMkW1WkBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hdW:3c3WgRoEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBDS1JvQVLMNU1u\WSrYYTl[EBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgOFghcHK|IHL5JGJzcXSnTHnnbJQhdHWlaX\ldoF{\SCjc4PhfUwhT0l3MDC9JFAvQDd2IN88UU4> MlvuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzBzM{e5PFEoRjNyMUO3PVgyRC:jPh?=
Sf9 MWnGeY5kfGmxbjDhd5NigQ>? Mn31WHBgXFKDTmPQU3JVTVJ8IHXm[ox2gCCxZjDIc4VkcHO2M{OzOFIhcW5iQlPSVE1mgHC{ZYPzbY5oKFOoOTDj[YxteyxiSVO1NEA:KDBwOTFOwG0v MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTF3NUi0NUc,OTVzNUW4OFE9N2F-
CHO NEL6ZZlHfW6ldHnvckBie3OjeR?= MUXJcohq[mm2aX;uJI9nKGOqaX3ldolkKFCGR1[gdoVk\XC2b4Kge4l1cCCFU1[tNXIh[3m2b4DsZZNucWNiZH;tZYlvKHCqb4PwbI9zgWyjdHnvckBqdiCFSF:gZ4VtdHNuIFnDOVAhRSByLkm2JO69VS5? NG\2fWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkG2Olk2OCd-MUKxOlY6PTB:L3G+
BA/F3 MkjLRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MWK3NkBpenN? MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNUGkbDDGN|U6XiCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOC57NjFOwG0v NYH5[2J1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3 NHXYNm1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXraW3JlPDhiaILz M1PCT2FvfGmycn;sbYZmemG2aX;uJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvYXLsJGE{OzSuIH31eIFvfCCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC57NkKg{txONg>? MmnOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ2MUW4OlMoRjF4NEG1PFY{RC:jPh?=
K562 NHSy[|REgXSxdH;4bYNqfHliYYPzZZk> MkTtNlQhcHK| MnvQR5l1d3SxeHnjbZR6KGGpYXnud5QhcW2jdHnubYIue2Wwc3n0bZZmKGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KFiWVDDhd5NigSxiSVO1NEA:KDFizszNMi=> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ4MUS2PEc,OzB{NkG0Olg9N2F-
BA/F3 MVjDfZRwfG:6aXPpeJkh[XO|YYm= MoTMO|IhcHK| NEm0TI1EgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRkS4OnMhdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDFizszNMi=> M4LGVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
GIST430 MVrDfZRwfG:6aXPpeJkh[XO|YYm= NEjwZ5g4OiCqcoO= M1Hl[mN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGdKW1R2M{CgZ4VtdHNiaHHyZo9zcW6pIFvJWEBXPjV2QTDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzT2yxIHHzd4F6NCCJSUWwJF0hOS5zIN88UU4> MlixQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7OUG0OlUoRjJ6OUmxOFY2RC:jPh?=
K562 MVTDfZRwfG:6aXPpeJkh[XO|YYm= M2LyflQ5KGi{cx?= NI\rW3REgXSxdH;4bYNqfHliaX6g[JJ2\yC|ZX7zbZRqfmViaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhYFSWIHHzd4F6NCCLQ{WwJF0hOS5zIN88UU4> MoSwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4NUW5PFEoRjJ7NkW1PVgyRC:jPh?=
IR-K562 MlToR5l1d3SxeHnjbZR6KGG|c3H5 M4rifGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGmvYYTpcoljKHKnc3nzeIFvfCCqdX3hckBKWi2NNU[yJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUwhUUN3MDC9JFEvOSEQvF2u Mn\HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ{NkS1NFMoRjJ4Mk[0OVA{RC:jPh?=
K562 NHW0d2hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NWHENWxuPDhiaILz M4HobWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMT6xOkDPxE1w NHXrfm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKzNVA4QSd-Mk[yN|ExPzl:L3G+
K562 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NFiwc3o1QCCqcoO= Mn3ER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDFwMU[g{txONg>? M{XFXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NEWxO|czLz5{NkS1NVc4OjxxYU6=
BA/F3 MoLISpVv[3Srb36gZZN{[Xl? NGSxOYY4OiCqcoO= M3rWR2lvcGmkaYTpc44hd2ZiS3n0JHY2PjCGL1S4NVZJKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiY3XscEBoem:5dHigbY5kfWKjdHXkJIZweiB5MjDodpMh[nliTWTTJIF{e2G7LDDHTVUxKD1iMT6xPVEh|ryPLh?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BAF3 MVrGeY5kfGmxbjDhd5NigQ>? NH\1O|E4OiCqcoO= M1P2XGlvcGmkaYTpc44hd2ZiVFXMMYZ2e2WmIHPLTXQhTDhzNligcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTCxMlI1PSEQvF2u Ml;FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
FDC-P1 MoXsSpVv[3Srb36gZZN{[Xl? NYfVbpBnPDhiaILz NF;nemFKdmirYnn0bY9vKG:oIHj1cYFvKE[PUzDlfJBz\XO|ZXSgbY4h\3Kxd4ToJIZi[3SxcjDk[ZBmdmSnboSgcY92e2ViRlTDMXAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gSm1UNW2nZHnheIVlKGOnbHygdJJwdGmoZYLheIlwdiCrbjDwdoV{\W6lZTDoeY1idiCFU1[xJIFnfGW{IES4JIhzeyCkeTDy[ZNignW{aX6g[JlmKHKnZIXjeIlwdiCjc4PhfUwhUUN3MDC9JFEvOjd2IN88UU4> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF3Nk[4PUc,OjBzNU[2PFk9N2F-
BAF3 NFf4VYdHfW6ldHnvckBie3OjeR?= M1;6b|czKGi{cx?= Ml;QTY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiY1vJWEBPQDJ{SzDteZRidnRiKIXub45wf25ib4Lp[4lvMSC2cnHud4Zm[3SnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB5MjDodpMh[nliY3XscJRqfGW{LXfsc{9ES0t6IHHzd4F6NCCJSUWwJF0hOS5{OTFOwG0v MnrGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{e3NFUoRjJ5MEe3O|A2RC:jPh?=
BAF3 MXfGeY5kfGmxbjDhd5NigQ>? NX3HOItRPzJiaILz MUnJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClLVvJWEBPQDJ{SzDteZRidnRiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gRmFHOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCvZXHzeZJm\CCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0t6IHHzd4F6NCCJSUWwJF0hOS5{OTFOwG0v MkDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
BA/F3 M3P2UWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M{fYXVczKGi{cx?= NUTvUVVDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhYTJ3M1[gcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEGuOFQ1KM7:TT6= M3juSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
BAF3 NWH4SmhHTnWwY4Tpc44h[XO|YYm= NH23Tog4OiCqcoO= NGPpXYxKdmirYnn0bY9vKG:oIGTFUE1nfXOnZDDjT2lVKE56MkLLJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gNU41PjZizszNMi=> MlfrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3NEG2PVUoRjJ6NUSxOlk2RC:jPh?=
BA/F3 NGHEOotHfW6ldHnvckBie3OjeR?= NV7rPFdzPzJiaILz MYjJcohq[mm2aX;uJI9nKEurdDDlfI9vKDFzIHTlcIV1cW:wIDi1OlAhfG9iNUe4JJJme2mmdXXzLUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBDSS:IMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KE2WUzDhd5NigSxiR1m1NEA:KDFwNUKzJO69VS5? NVrsOI8yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
BA/F3 NYnJNI5kS3m2b4TvfIlkcXS7IHHzd4F6 MWe3NkBpenN? MUjDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKFUj3BRmwhTTN3NVegcZV1[W62IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFEvPiEQvF2u M{j5[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
BA/F3 MVzGeY5kfGmxbjDhd5NigQ>? M1LSd|czKGi{cx?= M2PxRWlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwMWg{PjmSIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFEvPjlizszNMi=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
GIST882 NESyVIhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFnsVXE6PiCqcoO= MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEeLU2S4PFIh[2WubIOgZYZ1\XJiOU[gbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEGuO{DPxE1w NVX2TXJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0Olk2PDdpPkG5OFY6PTR5PD;hQi=>
GIST882 NGfsd4NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4nvXlk3KGi{cx?= NWCxVlZwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBqdWG2aX7pZk1{fXOlZYD0bYJt\SCqdX3hckBIUVOWOEiyJINmdGy|IHjhdoJwemmwZzDjMWtKXCCNNkSySUBufXSjboSgZYZ1\XJiOU[gbJJ{KGK7IGPSRkBie3OjeTygTWM2OCB;IEGuO{DPxE1w NHvTflM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUeyOFY2Oyd-Mkm3NlQ3PTN:L3G+
BAF3 NUf4NGtCTnWwY4Tpc44h[XO|YYm= M4TT[|czKGi{cx?= M{L4WWlvcGmkaYTpc44hd2ZiQlPSM2FDVCCyMkGwJIZ2e2mxbjDwdo91\WmwIFizOllRKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCEQV[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJI1m[XO3cnXkJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT|gh[XO|YYmsJGdKPTBiPTCxMlc6KM7:TT6= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BA/F3 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4\NZlczKGi{cx?= MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJGJkei2DYnygZYZ1\XJiN{KgbJJ{KGK7IFPDT{05KGG|c3H5MEBKSzVyIE2gNU45OzRizszNMi=> Mn3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BA/F3 M4O1fWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NWTS[Y11PzJiaILz NVexfXZDSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhTzJ3MFWgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEGuPFY{KM7:TT6= NYDLPXhkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
BA/F3 MVfGeY5kfGmxbjDhd5NigQ>? NVjSdZk4PzJiaILz MUXJcohq[mm2aX;uJI9nKEKFUj;BRmwheDJzMD3FNlU2UyCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTCxMlk{KM7:TT6= NEPSOZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BA/F3 MVrGeY5kfGmxbjDhd5NigQ>? NUnI[nZlPzJiaILz Mlr2TY5pcWKrdHnvckBw\iCWRVytV3JEKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gNk4yKM7:TT6= NG\HOok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
NCI-H1703 MmHqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NFy1Ung4OiCqcoO= MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INVcxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFIvOSEQvF2u MoTlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
BAF3 NWfy[5V6TnWwY4Tpc44h[XO|YYm= MnLiO|IhcHK| MojWTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCg[pV{cW:wIIDyc5RmcW5iRkOxO2whdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IEKuNVYh|ryPLh?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
BA/F3 NWTpV5RjTnWwY4Tpc44h[XO|YYm= MlPFO|IhcHK| Mn7KTY5pcWKrdHnvckBw\iCEQ2KvRWJNKHB{MUCtSlMyP0xibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIH3veZNmKEKDL1[zJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKG:{IFPDT{05KGG|c3H5MEBIUTVyIE2gNk4yPjlizszNMi=> NInoS4w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
BA/F3 M3\zOmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NV7IOZM{PzJiaILz M2\5OmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJGg{QT[UIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB{LkO3O{DPxE1w M3jHdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
HGC27 NIXPeZFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MVy5OkBpenN? MnPqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKR1OyO{Bk\WyuczDh[pRmeiB7NjDodpMh[nliU2LCJIF{e2G7LDDJR|UxKD1iMj60JO69VS5? NFzZ[5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUS2PVU1Pyd-MUm0Olk2PDd:L3G+
HGC27 Mmj4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MoPzPVYhcHK| NELWS5pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjHR|I4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCyMlQh|ryPLh?= NWDuVZdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NlQ3PTNpPkK5O|I1PjV|PD;hQi=>
BAF3 MkjYSpVv[3Srb36gZZN{[Xl? MkXVO|IhcHK| MXPJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJHY3PTSDIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBxem:uaX\ldoF1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzseIl1\XJvZ3zvM2NEUzhiYYPzZZktKEeLNUCgQUAzNjR7IN88UU4> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 NHzBXXRHfW6ldHnvckBie3OjeR?= M2PrOVczKGi{cx?= Mn\4TY5pcWKrdHnvckBw\iCWZXyt[pV{\WRiYz3LTXQhXjZ3NFGgcZV1[W62IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGJCTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25ibXXhd5Vz\WRiYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gc5IhS0ONODDhd5NigSxiR1m1NEA:KDJwNEmg{txONg>? M3vUPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BA/F3 Mm\WRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1j2WFczKGi{cx?= MXvBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHX4dJJme3OrbnegRoNzNUGkbDDGOFg3WyCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOi53NEeg{txONg>? Ml7YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BA/F3 MXHGeY5kfGmxbjDhd5NigQ>? M2PmRVczKGi{cx?= MlzqTY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIFS4NVYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSB{Lke0PUDPxE1w NHuzV2I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
HEK293 MYXGeY5kfGmxbjDhd5NigQ>? NVrjZ5FTOS53IH3pcpM> M3P1XGlvcGmkaYTpc44hd2ZiaIXtZY4hVUGWRULLMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgNU42KG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOi57IN88UU4> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ2MUCyPUc,OjN{NEGwNlk9N2F-
BA/F3 MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWe3NkBpenN? MonVRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO|aX7nJGJkei2DYnygSVI2PUtibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDJwOUWxJO69VS5? MmOwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BA/F3 MUfGeY5kfGmxbjDhd5NigQ>? M1HVW|czKGi{cx?= NI[3Z5dKdmirYnn0bY9vKG:oIGTFUE1FTFJzIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUy16IHHzd4F6NCCJSUWwJF0hOyEQvF2u MoTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BAF3 NUj0UFh1TnWwY4Tpc44h[XO|YYm= NXT5Wll6PzJiaILz NYTWWFVVUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ2tKXCCYNUW5SE9XPjV2QTDkc5VjdGVibYX0ZY51KCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHz0bZRmei2pbH:vR2NMQCCjc4PhfUwhT0l3MDC9JFMh|ryPLh?= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 MlrWSpVv[3Srb36gZZN{[Xl? M2jwNVczKGi{cx?= NW\kSHpKUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ{1MUVRiVkW1PWQwXjZ3NFGg[I92[mynIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUA{KM7:TT6= NIfkSJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
BA/F3 MmfWRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NHzRUlA4OiCqcoO= NWXBc2I2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKlcj3BZowhXDNzNVmgcZV1[W62IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEOuNFA2KM7:TT6= MlnaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
BA/F3 MkX0R5l1d3SxeHnjbZR6KGG|c3H5 MnXxO|IhcHK| NFGx[mZEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiRkOxO2whdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDNwMzFOwG0v NFKySGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
MDCK Mkf5SpVv[3Srb36gZZN{[Xl? MojKTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IHL5JJBp\W:yaH;yZoll\SCDIHHzd4F6NCCLQ{WwJF0hOy5|ODFOwG0v M4HaVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUOyPVYxLz5zOUmzNlk3ODxxYU6=
K562 NIDKZlFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NUftS5RTPzJiaILz M1;0XGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMz60N{DPxE1w Mn;lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OES3NFgoRjJ7Nki0O|A5RC:jPh?=
BA/F3 MU\DfZRwfG:6aXPpeJkh[XO|YYm= MX:3NkBpenN? MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{BmgHC{ZYPzbY5oKEKFUj3BRmwhWTJ3MligcZV1[W62IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDDR2suQCCjc4PhfUwhUUN3MDC9JFMvPiEQvF2u NXrjWpo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
BA/F3 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NHPRe|k4OiCqcoO= NF7IeZBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4PpcochSmO{LVHicEBSOjV{SDDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMz63OlMh|ryPLh?= NWDTSlFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFg3PDRpPkKzNFg5PjR2PD;hQi=>
HGC27 MmfjR5l1d3SxeHnjbZR6KGG|c3H5 M2fvPFQ5KGi{cx?= M4\EeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiJQ{K3JINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB|Lkig{txONg>? NXi3fpJERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA2QDRpPkK0PVAxPTh2PD;hQi=>
BA/F3 NE\CPFRHfW6ldHnvckBie3OjeR?= MU[3NkBpenN? MmO3TY5pcWKrdHnvckBw\iCNaYSg[ZhwdiB7IFHZOVAzKHSxIEWwN{BqdnOncoTpc44h[W6mIG[2OVQhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSB|Lkm0O{DPxE1w NX3XZW15RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyNFQ1PDFpPkOwNlA1PDRzPD;hQi=>
MCF7 MX M{e5U2Z2dmO2aX;uJIF{e2G7 MYTJcohq[mm2aX;uJI9nKEKFUmCg[ZhxemW|c3XkJIlvKE2FRkegUXgh[2WubIOgZpkhUG:nY3jzeEA{OzN2MjDzeIFqdmmwZzygTWM2OCB;IESuNFch|ryPLh?= M4HBblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUOyPVYxLz5zOUmzNlk3ODxxYU6=
BA/F3 NYnsb2l5TnWwY4Tpc44h[XO|YYm= MYm3NkBpenN? MXXJcohq[mm2aX;uJI9nKFSHTD3CUGshMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTC0MlEh|ryPLh?= NFfneGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
K562 MmOxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M{fRNlQ5KGi{cx?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLjdk9C[mxicH;zbZRqfmViaIXtZY4hUzV4MjDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIH3leIhw\CxiSVO1NEA:KDRwMUKg{txONg>? NHr5WY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2OFg5Pid-MkW0OlQ5QDZ:L3G+
K562 M4D1VmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFu1PWM1QCCqcoO= NFzzToZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESuNVIh|ryPLh?= M2PoSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mkm4OFk2Lz5{NkK5PFQ6PTxxYU6=
HEK293 NV;HRphWTnWwY4Tpc44h[XO|YYm= MUKzJI1qdnN? NF\FOnJKdmirYnn0bY9vKG:oIHj1cYFvKE:FVEKtcYVlcWG2ZXSgRXNRMyC3cIThb4Uh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bi\nSncjCzJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyIE2gOE4zKM7:TT6= NWfabnhsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFExOjlpPkKzNlQyODJ7PD;hQi=>
A549 NWHXR41rSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGTqSIg1QCCqcoO= NEHaRVBCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IESuOVYh|ryPLh?= MoPQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh3MkW4N|goRjJ6NUK1PFM5RC:jPh?=
K562/G M4Wwe2N6fG:2b4jpZ4l1gSCjc4PhfS=> NHf3d3U4OiCqcoO= M33ETGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJxRzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPC54NTFOwG0v MmPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6MUS4PVAoRjJ4OEG0PFkxRC:jPh?=
BAF3 NX2wdno1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NU\PeG5ZPzJiaILz NGnTTJFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBSlMh[2WubIOgZZN{\XO|ZXSgZZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3XscEB1cXSncj3ncI8h[XO|YYmsJGdKPTBiPTC0MlY5PiEQvF2u NHn4[3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BA/F3 M3PGTWN6fG:2b4jpZ4l1gSCjc4PhfS=> NGnjWZQ1QCCqcoO= MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJGJkei2DYnygWFMyPUlibYX0ZY51KGGodHXyJFQ5KGi{czDifUBZXFRiYYPzZZktKEmFNUCgQUA1Njd7IN88UU4> NUCyZm5pRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NFA5ODZpPkKzOlAxQDB4PD;hQi=>
MCF7 MXPGeY5kfGmxbjDhd5NigQ>? NWSwNWN2UW6qaXLpeIlwdiCxZjDBRmNIOiCrbjDoeY1idiCvaYTvfIFvfHKxbnWtdoV{cXO2YX70JG1ETjdiY3XscJMh[nliSH;lZ4h{fCB|M{O0NkBie3OjeTygTWM2OCB;IESuPFk4PzlizszNMi=> M2Xud|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6Nke4OFk2Lz5zOE[3PFQ6PTxxYU6=
Sf9 NUHHZmp{TnWwY4Tpc44h[XO|YYm= M4P3TGJqdmSrbnegZYZncW6rdImgeI8hemWlb33ibY5idnRiZoXscEBt\W6pdHigbJVu[W5iTj30[ZJucW6jbDDHV3QufGGpZ3XkJHN6cy2NRDCoN|U3KHSxIE[zOUBz\XOrZIXld{kh[3m2b4DsZZNucWNiZH;tZYlvKGW6cILld5Nm\CCrbjDiZYN2dG:4aYL1d{Bqdm[nY4Tl[EBU\jliaX7z[YN1KGOnbHzzJJV{cW6pIIDvcJkhTVliNEqxJIF{KHO3YoP0doF1\SxiS3mgQUA2KM7:TT6= M1faW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUOyO|UzLz5{OUGzNlc2OjxxYU6=
insect cells MkHCSpVv[3Srb36gZZN{[Xl? MlrPN|AhdWmwcx?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEGETEGgWFMyPUlibYX0ZY51KGW6cILld5Nm\CCrbjDpcpNm[3RiY3XscJMh[W[2ZYKgN|AhdWmwczDifUBHWkWWIHHzd4F6NCCLQ{WwJF0hPS5zNUWg{txONg>? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
BA/F3 MkfoR5l1d3SxeHnjbZR6KGG|c3H5 MWS3NkBpenN? NXznSFVrS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCR3IuSUKOIFeyOVBGKG23dHHueEBie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB3LkKg{txONg>? NFPqRoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
HEL NXf1UZJkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NHnOZYw4OiCqcoO= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiHTDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0tvODDhd5NigSxiR1m1NEA:KDVwMzFOwG0v M4TTUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{i5OVU{Lz5{Nke4PVU2OzxxYU6=
K562 NV75clZUSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MlTNOFghcHK| MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNDFOwG0v M3TMSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUe2NFI{Lz5{MUW3OlAzOzxxYU6=
KBM5 NGrrc45EgXSxdH;4bYNqfHliYYPzZZk> MojLO|IhcHK| Mlv3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2JOPSClZXzsd{Bp[XKkb4LpcochSmO{LVHicEBVOzF3STDteZRidnRiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDVwNDFOwG0v NFXSeFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0PVY3PSd-MkCxOFk3PjV:L3G+
BA/F3 NGficoREgXSxdH;4bYNqfHliYYPzZZk> MYi3NkBpenN? MmfVR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKEV{NUXLJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA2NjZizszNMi=> Mnf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
BAF3 MYPGeY5kfGmxbjDhd5NigQ>? NUfwWmNHPzJiaILz M1[yNmlvcGmkaYTpc44hd2ZiVHXsMYZ2e2WmIHPLTXQhXDZ5MFmvWlU2QURiZH;1ZoxmKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFczKGi{czDifUBk\WyudHn0[ZIu\2yxL1PDT|gh[XO|YYmsJGdKPTBiPTC2MlY4KM7:TT6= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BAF3 M4nuUmZ2dmO2aX;uJIF{e2G7 MVW3NkBpenN? NUj6TFFCUW6qaXLpeIlwdiCxZjDU[Ywu\nW|ZXSgZ{1MUVRiVE[3NGkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IE[uOlch|ryPLh?= M4LYTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
BA/F3 Ml;vRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mn;DO|IhcHK| NYPZNIxiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCxcjDDR2suQCCjc4PhfUwhT0l3MDC9JFYvPyEQvF2u NV\I[JB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3PFk2PTNpPkK2O|g6PTV|PD;hQi=>
GIST48B NF\FTm1CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NVTJZ3RyPzJiaILz MlXERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCJSWPUOFhDKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG|c3H5MEBIUTVyIE2gOk46QDZizszNMi=> NGfDPXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
BaF3 NVvDeIIySW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH31dolv\SCEYV[zJINmdGy|IHX4dJJme3Orbnege4lt\CC2eYDlJG5RVS:DTFugZpkhYzOKXYTofY1q\GmwZTD1dJRic2ViYYPzZZktKEmFNUCgQUA4NjFizszNMi=> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjl5MESwNEc,OTZ7N{C0NFA9N2F-
MCF7 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MUW3NkBpenN? MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDdwMUKg{txONg>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6NEewPEc,Ojl4OES3NFg9N2F-
A2780 NFLnWZNHfW6ldHnvckBie3OjeR?= Ml;6TY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJIFlemmjbYnjbY4uemW|aYP0ZY51KEF{N{iwJINmdGy|IHL5JGhw\WOqc4SgN|M{PDJiYYPzZZktKEmFNUCgQUA4NjJ2NEO2JO69VS5? NXvyeItTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2O|g1QTVpPkG4Olc5PDl3PD;hQi=>
A2780/ADR NIeyWoJHfW6ldHnvckBie3OjeR?= MVvJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIV5eHKnc4Pl[EBqdiCDMke4NE9CTFJiY3XscJMh[nliY3HsZ4VqdiCDTTDhd5NigSxiSVO1NEA:KDdwMkS0N|Yh|ryPLh?= M{freVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEmwNFk1Lz5zN{i5NFA6PDxxYU6=
BA/F3 MnXCSpVv[3Srb36gZZN{[Xl? NX7VTlhnPzJiaILz NV7ZNopuUW6qaXLpeIlwdiCxZjDUSWwuTESUMjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBud3W|ZTDCRU9HOyClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubGTpeIVzNUeubzDvdkBES0tvODDhd5NigSxiR1m1NEA:KDdwNzFOwG0v Mn7hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
HEK293 MU\DfZRwfG:6aXPpeJkh[XO|YYm= NU\qfZVRS3m2b4TvfIlkcXS7IHHnZYlve3RiSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSxiQ1O1NEA:KDhwNDFOwG0v M1\4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4Mk[0OVA{Lz5{NkK2OFUxOzxxYU6=
FDC-P1 MkTySpVv[3Srb36gZZN{[Xl? NWDUNmJlPDhiaILz M{H6U2lvcGmkaYTpc44hd2ZibX;1d4UhT01vQ2PGMZN1cW23bHH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKG:oIHfyc5d1cCCoYXP0c5Ih\GWyZX7k[Y51KG2xdYPlJGZFSy2SMTDj[YxteyCneIDy[ZN{cW6pIHj1cYFvKE[PUzDh[pRmeiB2ODDodpMh[nlicnXzZZp2emmwIHT5[UBz\WS3Y4Tpc44h[XO|YYmsJGlEPTBiPTC4MlQ{PyEQvF2u MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF3Nk[4PUc,OjBzNU[2PFk9N2F-
BA/F3 MlvqRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M4f2OFczKGi{cx?= M4[2Z2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJGUzPTWYIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSB6Lk[xOUDPxE1w MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
A2780 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NXPxOppYPzJiaILz NGTD[HZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGyO|gxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC4Mlkh|ryPLh?= NHTLVoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[4OFcxQCd-Mkm2PFQ4ODh:L3G+
BESM M1nhOGFvfGm2conwZY5we2:vYXygZZN{[Xl? MnOyPFghcHK| M4jydGFvfGm2conwZY5we2:vYXygZYN1cX[rdImgZYdicW6|dDDUdplx[W6xc3;tZUBkenW8aTDhcYF{fGmpb4Tld{Bqdm[nY4Tl[EBqdiCERWPNJINmdGy|IH3lZZN2emWmIHHmeIVzKDh6IHjyd{Bxd3O2aX7m[YN1cW:wIHL5JGhVWyCjc4PhfUwhTUN3MDC9JFkh|ryPLh?= MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODV2N{ixPUc,OjB3NEe4NVk9N2F-
BaF3 M37TdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NX3wUJFoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBufXKrbnWgRoFHOyClZXzsd{BmgHC{ZYPzbY5oKE6STT;BUGshVDJ3NmSgcZV1[W62IHL5JHs{UF22aIntbYRqdmVidYD0ZYtmKGG|c3H5MEBKSzVyIE2gPU4yKM7:TT6= NVzpS3liRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5O|A1ODBpPkG2PVcxPDByPD;hQi=>
BA/F3 NI\oR5hEgXSxdH;4bYNqfHliYYPzZZk> NYrHRop7PzJiaILz NGS5bWFEgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBDSS:IMzDj[YxteyCneIDy[ZN{cW6pIFLDVk1CSkxiWUK1N2YhdXW2YX70JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDlwMjFOwG0v MoSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEG3NFMoRjJ|M{CxO|A{RC:jPh?=
BA/F3 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NUPmXGJESW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkhdW:3c3WgRmEwTjNiY3XscJMhcW5icILld4Vv[2Vib3[gbY51\XKuZYXrbY4hOyxiSVO1NEA:KDlwNEW5JO69VS5? NUTpTZhRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
BA/F3 NH7mRoFEgXSxdH;4bYNqfHliYYPzZZk> NHXaNIw4OiCqcoO= MoPUR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKEZ|MUfWJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUA6NjVizszNMi=> M{TZeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
Ba/F3 NYKzd4N[TnWwY4Tpc44h[XO|YYm= NXf3eFM5PDhiaILz M3\MemlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiVEOxOWkhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKG2xdYPlJGJiN0Z|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUA6NjZ2NTFOwG0v M2ThZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5|MEGzO|k5OTxxYU6=
BA/F3 M1G2XmZ2dmO2aX;uJIF{e2G7 NHm0TVM4OiCqcoO= MXvJcohq[mm2aX;uJI9nKFSHTD3IR2shMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO|YYmsJGdKPTBiPTC5Mlch|ryPLh?= MmHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm1OVMoRjJ4N{i5OVU{RC:jPh?=
BA/F3 NFH1NoVHfW6ldHnvckBie3OjeR?= NUL0bGo3PzJiaILz NWfybVRLUW6qaXLpeIlwdiCxZjDLbZQhTDhzNm[gcZV1[W62IDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUA6Njl|IN88UU4> M{PSOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMkC0OFQyLz5|MEKwOFQ1OTxxYU6=
HCT116 NXTtN3pSS3m2b4TvfIlkcXS7IHHzd4F6 MkLhO|IhcHK| NEXmNWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNVAh|ryPLh?= NGT6[lA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HepG2 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NF;6OoEzPCC2bzC5OkBpenN? Ml3zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKZYDHNkBk\WyuczDh[pRmeiB{NDD0c{A6PiCqcoOgZpkhVVSVIHHzd4F6NCCLQ{WwJF0hOTBizszNMi=> MnvNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO|EoRjJ|OUOyNFcyRC:jPh?=
BA/F3 MV7DfZRwfG:6aXPpeJkh[XO|YYm= NUOw[YdDPzJiaILz M3rF[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCKM{m2VkBufXSjboSgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTFwMTFOwG0v MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
MCF7 M3XX[GFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NI[yelg6PiCqcoO= NVnjSXBoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxNU4{KM7:TT6= M1jwNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{K0OlU{Lz5{OUeyOFY2OzxxYU6=
MCF7 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M2DhNlk3KGi{cx?= MULBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhQTZiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDFzLkWg{txONg>? MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4OUW0O{c,OTl2Nkm1OFc9N2F-
RKOp21 NX7UdWMyS3m2b4TvfIlkcXS7IHHzd4F6 MY[3NkBpenN? MoLoR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVmtQeDJzIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEGyJO69VS5? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
BA/F3 MnTnR5l1d3SxeHnjbZR6KGG|c3H5 MVq3NkBpenN? M4PFOGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCCOMkS4WkBufXSjboSgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTJwMjFOwG0v NXXkUJFERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
BA/F3 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NVnQe285PzJiaILz MlezR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yCEQ2KtRWJNKFR|MUXJJI12fGGwdDDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR2NMNThiYYPzZZktKEmFNUCgQUAyOi5{IN88UU4> NUe1UoZSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN|AyPzB|PD;hQi=>
BA/F3 MVzDfZRwfG:6aXPpeJkh[XO|YYm= MXS3NkBpenN? M{iwTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KG2xdYPlJGJCN0Z|IHPlcIx{KGW6cILld5NqdmdiQlPSMWFDVCC\MkWzTEBufXSjboSgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNEUy16IHHzd4F6NCCLQ{WwJF0hOTJwNTFOwG0v MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMUewN{c,OjN|MEG3NFM9N2F-
RKOp21 M{nWOmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUW4SWpbPzJiaILz NFu2enhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTU0:yMkGgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNVIvPTh7MjFOwG0v NH7sZYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
K562 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MVeyOEBpenN? NVL2dFB4UW5idnn0do8h[W62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAyOyEQvF2u NXLaOlNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFE6QDZpPkK0OlgyQTh4PD;hQi=>
BA/F3 M{nHOGN6fG:2b4jpZ4l1gSCjc4PhfS=> MnL2O|IhcHK| Mki1R5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOFSz24JIF{e2G7LDDJR|UxKD1iMUOuOUDPxE1w M3HLflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
U937 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWC1VZZ4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBWQTN5IHPlcIx{NCCLQ{WwJF0hOTRizszNMi=> M3m2XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4M{OyOFQxLz5zNkOzNlQ1ODxxYU6=
BA/F3 MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmrqOFghcHK| NULXZXVHT3Kxd4ToJIlvcGmkaYTpc44hd2ZibX;1d4UhSkFxRkOgZ4VtdHNiZYjwdoV{e2mwZzDCZ5IuSWKuIGSzNVVKKG23dHHueEBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVQvPSEQvF2u MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV4MkKxO{c,OjZ3NkKyNVc9N2F-
A549 M2rQfWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mle5O|IhcHK| MmDHR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzNT61JO69VS5? MlPWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
K562 M3ru[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXvDZ|h7PDhiaILz NV;mSWZGSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBqdWG2aX7pZk1z\XOrc4ThcpQhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVUvPyEQvF2u M4\Gd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkOxNFc6Lz5{NkKzNVA4QTxxYU6=
MDA-MB-468 NIDxTphEgXSxdH;4bYNqfHliYYPzZZk> M2H4WVczKGi{cx?= MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNE[4JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCjbHHtZZIu[my3ZTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE2Njh2OEmg{txONg>? NVz3UnBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
KG1a M4W4UGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MVe3NkBpenN? M3L6Z2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1exZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwhe3W{dnn2ZYwh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFE3NjdizszNMi=> MmnxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ6NUCwNFQoRjJ4OEWwNFA1RC:jPh?=
MDA-MB-468 M1PFbmN6fG:2b4jpZ4l1gSCjc4PhfS=> MnfmO|IhcHK| NXz5PVFnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ3QCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzNzFOwG0v NELFdpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HMC-1.2 M4fHWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NYjhTGlUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUWMuOS5{IHPlcIx{KGOjcoL5bY5oKFZ3NkDHMEBFQDF4VjDteZRidnRiYYPz[ZN{\WRiYYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxO{DPxE1w NHThWFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUCwOFQxQSd-MkWwNFQ1ODl:L3G+
BA/F3 NYPaUnNjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NEDmZ2k4OiCqcoO= M3rp[mFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW|c3nu[{BD[3JvQXLsJHkzPTOKIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSBzNz6wPFMh|ryPLh?= MoOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ|MEi4OlQ1RC:jPh?=
HUVEC Mon2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MYXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFjVWmVEKGOnbHzzMEBIUTVyIE2gNVgvPSEQvF2u NWe4UGJHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N|k3PzRpPkKyOFM6Pjd2PD;hQi=>
BA/F3 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1;zRlczKGi{cx?= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IH3veZNmKEKDL1[zJINmdGy|IHHmeIVzKDd{IHjyd{BjgSCFQ1utPEBie3OjeTygTWM2OCB;IEG4MlUzKM7:TT6= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB6OE[0OEc,OjNyOEi2OFQ9N2F-
HeLa NWPzdHZzS3m2b4TvfIlkcXS7IHHzd4F6 NWrPcmtqPzJiaILz NESzfXNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG4MlY2KM7:TT6= MlLYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
GIST48 NUXZe3B4S3m2b4TvfIlkcXS7IHHzd4F6 NYTMPYlOOyC2bzC2JIRigXN? MVjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDHTXNVPDhiY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIHPlcIwhfmmjYnnsbZR6KGGodHXyJFMhfG9iNjDkZZl{KGK7IHz1Z4ln\XKjc3WgZoF{\WRibIXtbY5me2OnbnPlJIF{e2G7LDDJR|UxKD1iMUiuO{DPxE1w MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTR4OUW0O{c,OTl2Nkm1OFc9N2F-
Hec1A M2HrTWN6fG:2b4jpZ4l1gSCjc4PhfS=> M13rSVczKGi{cx?= MmPmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVkOUFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUmg{txONg>? NH3ublU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
U937 NF\uXoVEgXSxdH;4bYNqfHliYYPzZZk> MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPVM4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSxiSVO1NEA:KDF7IN88UU4> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
HCT116 MmXHRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGPxSYI4OiCqcoO= M1vQOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxPU43PiEQvF2u NFHCZVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[4OFcxQCd-Mkm2PFQ4ODh:L3G+
GIST48 NIO5cJBCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M2O2[lk3KGi{cx?= NXXnW3l1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBqdWG2aX7pZk1z\XOrc4ThcpQhcHWvYX6gS2lUXDR6IHPlcIx{KGijcnLvdolv\yClLVvJWEBXPTZyRD;EPFIxSSCmb4XicIUhdXW2YX70JIFnfGW{IEm2JIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxPU45KM7:TT6= NGjYcGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUeyOFY2Oyd-Mkm3NlQ3PTN:L3G+
A549 MnmwR5l1d3SxeHnjbZR6KGG|c3H5 NESzbow4OiCqcoO= Mm\2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSBzOT65OVI3KM7:TT6= Mnm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CAL27 NHO4cHBEgXSxdH;4bYNqfHliYYPzZZk> MlrSO|IhcHK| MnexR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUmuPVUzPiEQvF2u MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
Hec1A MoWyR5l1d3SxeHnjbZR6KGG|c3H5 M3HTTVczKGi{cx?= MnXlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVkOUFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUmuPVUzPiEQvF2u MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
32D M2jGWGN6fG:2b4jpZ4l1gSCjc4PhfS=> MWHDfZRwfG:6aXOgZYN1cX[rdImgZYdicW6|dDDtc5V{\SB|MlSgRoNzNWGkbDDu[YdifGm4ZTDj[YxteyxiSVO1NEA:KDJyIN88UU4> NHjH[ng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSxOVg3Oyd-MU[0NVU5PjN:L3G+
GIST48B MonWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\aPHI4OiCqcoO= NXLDRZlpT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hT0mVVES4RkBk\WyuczDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDHTVUxKD1iMkCg{txONg>? MkT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5N{OxOVMoRjJ|N{ezNVU{RC:jPh?=
BV173 MUHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFq3VYwzPCCqcoO= MnrTTY4hfmm2cn:gZY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEVkG3N{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNlAh|ryPLh?= MlnPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
BAF3 MVjGeY5kfGmxbjDhd5NigQ>? M1HicVczKGi{cx?= NH;HVGhKdmirYnn0bY9vKG:oIFHCUEBVOzF3STDteZRidnRiaX6gcY92e2ViQlHGN{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIxNjB|IN88UU4> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl5NEOzPEc,Ojh7N{SzN|g9N2F-
293T MoW4R5l1d3SxeHnjbZR6KGG|c3H5 M4naNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFI6O1RiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25uIFPDOVAhRSB{MD61N{DPxE1w NVvxOmlrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4OVAxODRpPkK2PFUxODB2PD;hQi=>
CAL27 NWPFbGljS3m2b4TvfIlkcXS7IHHzd4F6 NXHYR41qPzJiaILz MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{MjFOwG0v NETYWFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H460 NUL1NJFZS3m2b4TvfIlkcXS7IHHzd4F6 NV7wTZg4PzJiaILz MnPCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NDFOwG0v NY[yeGJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
PC3 MUnDfZRwfG:6aXPpeJkh[XO|YYm= MYO3NkBpenN? NYDPVlFrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEK0JO69VS5? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
HCT15 NE\RSpZEgXSxdH;4bYNqfHliYYPzZZk> Mom1O|IhcHK| MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyPSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NTFOwG0v MkHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
THP1 NUPwTnRtS3m2b4TvfIlkcXS7IHHzd4F6 NVHxSmNMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hXEiSMTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImsJGlEPTBiPTCyOUDPxE1w MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ4NEWwN{c,OjZ{NkS1NFM9N2F-
HeLa MUfDfZRwfG:6aXPpeJkh[XO|YYm= M1flXVczKGi{cx?= NXfWb4VJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyOU4yOTh7IN88UU4> NUT4OXpDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
H460 M4q5NWN6fG:2b4jpZ4l1gSCjc4PhfS=> NH3NW2Q4OiCqcoO= M2S3V2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMkWuNVE5QSEQvF2u NEmyO3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
HCT15 M1fU[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MWW3NkBpenN? MkLvR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMkWuNVE5QSEQvF2u NGDPb4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
PC3 MkHsR5l1d3SxeHnjbZR6KGG|c3H5 M{C0SlczKGi{cx?= M{K2VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEOyClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{NT6xNVg6KM7:TT6= NU\TVZBtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
Saos2 NInVXVlEgXSxdH;4bYNqfHliYYPzZZk> NEXVPW04OiCqcoO= NITuZ3BEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBU[W:|MjDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyOU4yOTh7IN88UU4> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
HEK293 MWPGeY5kfGmxbjDhd5NigQ>? NVvmNnBGOyCvaX7z NYf1XmNYUW6qaXLpeIlwdiCxZjDoeY1idiCRQ2SzMY1m\GmjdHXkJGFUWCtidYD0ZYtmKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[W[2ZYKgN{BucW6|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFI2NjVizszNMi=> M1LLTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MkSxNFI6Lz5{M{K0NVAzQTxxYU6=
Saos2 M4TKUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NYjzZotmPzJiaILz M2H1Z2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNid3N{IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEK2JO69VS5? NHrBWlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
MCF7 M{nqVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MVm3NkBpenN? NE\pNnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOwJO69VS5? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
A431 MULDfZRwfG:6aXPpeJkh[XO|YYm= MX[3NkBpenN? MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDNzIN88UU4> NFrsNXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
H69 NGHmcIlEgXSxdH;4bYNqfHliYYPzZZk> M4HHWlczKGi{cx?= MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOlkh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzFwNkKyPEDPxE1w MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTNyMUmwNkc,OTl|MEG5NFI9N2F-
MCF7 MlnRR5l1d3SxeHnjbZR6KGG|c3H5 NHXtN|I4OiCqcoO= M17y[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{GuOlIzQCEQvF2u M1uxcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
A431 M3zLN2N6fG:2b4jpZ4l1gSCjc4PhfS=> MXq3NkBpenN? MYjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDNzLk[yNlgh|ryPLh?= NXrIWFdVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
H69 MXvDfZRwfG:6aXPpeJkh[XO|YYm= NWPTWmlKPzJiaILz NYTlfFF7S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUDZ7IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyJO69VS5? NYLu[IRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
BESM NHHBbGNEgXSxdH;4bYNqfHliYYPzZZk> M1vDSlg5KGi{cx?= NYL2S|BtS3m2b4TvfIlkcXS7IHHnZYlve3RiQlXTUUBk\WyuczDh[pRmeiB6ODDodpMh[nliSGTTJIF{e2G7LDDFR|UxKD1iM{Kg{txONg>? NFHhXGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEW0O|gyQSd-MkC1OFc5OTl:L3G+
HCT116 M1zn[GFvfGmlYX7j[ZIh[XO|YYm= M4\UcWFvfGmlYX7j[ZIh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMtKEmFNUCgQUA{PC52IN88UU4> NYPwVXA5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zNVI1OzRpPkK2N|EzPDN2PD;hQi=>
CCRF-CEM NXPHPGkxS3m2b4TvfIlkcXS7IHHzd4F6 M4rwc|czKGi{cx?= MoTWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2NTTi2FRV2gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gN|Yh|ryPLh?= MoHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
MDA-MB-231 NYLu[2xoS3m2b4TvfIlkcXS7IHHzd4F6 MnyzO|IhcHK| NVH0XlI4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB|NzFOwG0v NHriN3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
CCRF-CEM/VCR1000 MWTDfZRwfG:6aXPpeJkh[XO|YYm= M3nob|czKGi{cx?= MmXvR5l1d3SxeHnjbZR6KGGpYXnud5QhfmmwY4Lpd5RqdmVvcnXzbZN1[W62IHj1cYFvKEOFUl[tR2VON1[FUkGwNFAh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IHHsZY1iei2kbIXlJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzdizszNMi=> Mo\VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
WM266.4 M{PjemN6fG:2b4jpZ4l1gSCjc4PhfS=> MlzIO|IhcHK| M2KzS2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHdOOjZ4LkSgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gN|ch|ryPLh?= NFvG[WE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
U87MG MWTDfZRwfG:6aXPpeJkh[XO|YYm= MmnzO|IhcHK| MXzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB|ODFOwG0v NISyZ|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUOwNVkxOid-MUmzNFE6ODJ:L3G+
SKBR3 MkLjR5l1d3SxeHnjbZR6KGG|c3H5 M2K4W|czKGi{cx?= M3zjbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO5JO69VS5? NWryR3FxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
MDA-MB-231 M3myd2N6fG:2b4jpZ4l1gSCjc4PhfS=> M3\yVVczKGi{cx?= MoPjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliYXzhcYFzNWKudXWgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA{QS56MUC3JO69VS5? Ml3NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
SKBR3 NV7TdmVrS3m2b4TvfIlkcXS7IHHzd4F6 NWHROW14PzJiaILz Ml\pR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{muPFExPyEQvF2u NX72VHhnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
AsPC1 NGP0d3FEgXSxdH;4bYNqfHliYYPzZZk> MVq3NkBpenN? M{HDVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{WENzIHPlcIx{KGGodHXyJFczKGi{czDifUBidGGvYYKtZox2\SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEO5MlgyODdizszNMi=> NVTpWZd[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N|AyQTB{PD;hQi=>
CCRF-CEM/VCR1000 MoK3R5l1d3SxeHnjbZR6KGG|c3H5 NX3FR|djPzJiaILz M2fhc2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnPybZN1cW6nLYLld4l{fGGwdDDoeY1idiCFQ2LGMWNGVS:YQ2KxNFAxKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDhcIFu[XJvYnz1[UBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDN7LkixNFch|ryPLh?= Ml[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CCRF-CEM M2q2PGN6fG:2b4jpZ4l1gSCjc4PhfS=> Mn\rO|IhcHK| MmnNR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2NTTi2FRV2gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gN|kvQDFyNzFOwG0v MonQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
U87MG NHLr[WtEgXSxdH;4bYNqfHliYYPzZZk> Mn61O|IhcHK| MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB|OT64NVA4KM7:TT6= M3u5OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{CxPVAzLz5zOUOwNVkxOjxxYU6=
WM266.4 M13FVWN6fG:2b4jpZ4l1gSCjc4PhfS=> MoXqO|IhcHK| MliwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW20zPjZwNDDj[YxteyCjZoTldkA4OiCqcoOgZpkh[WyjbXHyMYJtfWViY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCzPU45OTB5IN88UU4> Mmq0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
AsPC1 NGPt[pdEgXSxdH;4bYNqfHliYYPzZZk> M{izNlczKGi{cx?= NYP0OZJ3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSXOSQ{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KGGuYX3hdk1jdHWnIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFQh|ryPLh?= Mki2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
CCRF-CEM NYDWSldbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NVX0TVE3OjRiaILz M2jtTGlvKH[rdILvJIFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQ1PSSk1ETU1iY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDR3IN88UU4> M17WflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
A2780 MWLDfZRwfG:6aXPpeJkh[XO|YYm= NXWzbIl[PzJiaILz MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC3NkBpenNiYomgZYxidWG{LXLseYUh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2ODFOwG0v Mn22QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl|MEG5NFIoRjF7M{CxPVAzRC:jPh?=
Vero MU\BcpRqfmm{YXygZZN{[Xl? NV30RmNsOyCmYYnz M320WGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGRmdme3ZTD2bZJ2eyCrbn\lZ5Rm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGGmbXnubZN1\XKnZDDi[YZwemVidnnyZYwh[2ijbHzlcodmKGGodHXyJFMh\GG7czDifUB3cXKjbDDwcIFyfWViYYPzZZk> NIDhUVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O2NFY4Pid-MUezOlA3PzZ:L3G+
Ba/F3 MUXGeY5kfGmxbjDhd5NigQ>? MknjNUB2VQ>? MmT5NlQhcHK| MmC4TY5pcWKrdHnvckBw\iBzND2zMVN{cWevYTDpckBpfW2jbjDCZU9HOyClZXzsd{BmgHC{ZYPzbY5oKHerbHSgeJlx\SCEY4KtRYJtKGOxboP0dpVkfCCjc4Pld5Nm\CCjczDy[Yxm[XOnIH;mJIZ2dGxvbHXu[5RpKGNvQXLsJIZzd21iY4n0c5Bt[XOvaXOgZ49ueGyneDD3bZRpKDF2LUOtN5Nq\22jIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KGmvbYXuc5Bz\WOrcHn0ZZRqd25xaX3teY5w[myxdDD0[YNpdmmzdXW= NFXtW2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2NlU4Pid-MkG5OlI2PzZ:L3G+
Ba/F3 MYnGeY5kfGmxbjDhd5NigQ>? NXHXXIZlOSC3TR?= MYCyOEBpenN? M{nTWGlvcGmkaYTpc44hd2ZiMUStN{0{e2mpbXGgbY4hcHWvYX6gRoEwTjNiY3XscJMh\XiycnXzd4lv\yC5aXzkJJR6eGViQnPyMWFjdCClb37zeJJ2[3RiYYPz[ZN{\WRiYYOgcpVkdGWjcjDpcZBwenRib3[g[pVtdC2uZX7neIgh[y2DYnygZZQhOSC3TTDh[pRmeiB{NDDodpMh[nliaX3teY5weHKnY3nwbZRifGmxbj;pcY12dm:kbH;0JJRm[2iwaYH1[S=> NYm5OHNQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OlI2PzZpPkKxPVYzPTd4PD;hQi=>
Neuro2a NY\UWmlNTnWwY4Tpc44h[XO|YYm= MWqxJJVO M1;NfGlvcGmkaYTpc44hd2ZiRGKyOEBqdiCGaHPyO{1l\W[rY3nlcpQhdW:3c3WgUoV2em9{YTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckA4NUSKQzDs[ZZmdHNiYYSgNUB2VSCkeTDMR{1OWy:JQz3NV{BidmGueYPpdy=> MmLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ5OEm2OVcoRjJ4N{i5OlU4RC:jPh?=
K562 MkTsSpVv[3Srb36gZZN{[Xl? MmnoNVAxKHWP NWTOZXlIQCCqcoO= NUTpelFiUW6qaXLpeIlwdiCxZjDCR3IuSUKOIIPp[45idGmwZzDwZZRpf2G7IHnuJIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhe3WycILld5Nqd25ib3[gV3RCXDVicHjvd5Bpd3K7bHH0bY9vKGG2IEGwNEB2VSCjZoTldkA5KGi{czDpckBxemW|ZX7j[UBw\iCPZVLTJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NVvUUnBzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OlY3OzVpPkK3OlY3PjN3PD;hQi=>
K562 MYTGeY5kfGmxbjDhd5NigQ>? M2ftNlExOCC3TR?= MYq4JIhzew>? NEjwN2pKdmirYnn0bY9vKG:oIFLDVk1CSkxiaX6gd4lodmGuaX7nJJBifGi5YYmgbJVu[W5iS{W2NkBk\WyuczDhd5Nme3OnZDDhd{B{fXCycnXzd4lwdiCxZjDDdotNKHCqb4PwbI9zgWyjdHnvckBifCBzMECgeW0h[W[2ZYKgPEBpenNiaX6gdJJme2WwY3Wgc4YhVWWEUzDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? Mo\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd4Nk[2N|UoRjJ5Nk[2OlM2RC:jPh?=
K562 M3vSUWZ2dmO2aX;uJIF{e2G7 MlH6NVAxKHWP M3XTOVghcHK| M33PPWlvcGmkaYTpc44hd2ZiQlPSMWFDVCCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hUzV4MjDj[YxteyCjdDCxNFAhfU1iYX\0[ZIhQCCqcoOgbY4heHKnc3XuZ4Uhd2ZiTXXCV{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= NUL2U|hCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke2OlY3OzVpPkK3OlY3PjN3PD;hQi=>
K562 M{iwN2Z2dmO2aX;uJIF{e2G7 NVzMSlBuOTBidV2= NHq5RpgyKGi{ M4HP[2lvcGmkaYTpc44hd2ZidInyc5NqdmVicHjvd5Bpd3K7bHH0bY9vKG:oIIDyc5RmcW5id3n0bEBud2ynY4XsZZIhf2WrZ3j0JIJmfHenZX6gOFAh[W6mIE[wJItF[SCrbjDoeY1idiCNNU[yJINmdGy|IHH0JFExKHWPIHHmeIVzKDFiaIKgZpkhcW2vdX7vZoxwfCCjbnHsfZNqew>? MnHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OEG5PFYoRjJ2NkixPVg3RC:jPh?=
K562 NF3BW3pHfW6ldHnvckBie3OjeR?= MkKzNVAhfU1? NUixXFB2OSCqch?= NH[3bJdKdmirYnn0bY9vKG:oIFLjdk9C[mxia3nuZZNmKHS7cn;zbY5mKHCqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBMPTZ{IHPlcIx{KGG2IEGwJJVOKGGodHXyJFEhcHJiYomgbY1ufW6xYnzveEBidmGueYPpdy=> NUHwdGgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PFE6QDZpPkK0OlgyQTh4PD;hQi=>
K562 M{ntRmZ2dmO2aX;uJIF{e2G7 MYmxNEB2VQ>? M4fTcFEhcHJ? MXzJcohq[mm2aX;uJI9nKEGkbDDrbY5ie2VidInyc5NqdmVicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYSgNVAhfU1iYX\0[ZIhOSCqcjDifUBqdW23bn;icI91KGGwYXz5d4l{ M1f4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkixPVg3Lz5{NE[4NVk5PjxxYU6=
DAOY MmXqdWhVWyCjc4PhfS=> NUHaXFhKeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhTEGRWTDj[Yxtew>? MljuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NCI-H1703 MX3GeY5kfGmxbjDhd5NigQ>? NF73UZAyKHWP M4DDUlIhcHK| M4Tz[mlvcGmkaYTpc44hd2ZiUFTHSk1qdmS3Y3XkJHBFT0[UYXzwbIEh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZO|U1KHKnc3nkeYUhcW5iaIXtZY4hVkOLLVixO|A{KGOnbHzzJIF1KDFidV2gZYZ1\XJiMjDodpMhcW5icILld4Vv[2Vib3[gVGRITi2DQTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? NEOyTIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUW0OFE1QSd-Mkm1OFQyPDl:L3G+
NCI-H1703 M3fDS2Z2dmO2aX;uJIF{e2G7 NGG4TYoyKHWP Mli4NkBpenN? Ml7nTY5pcWKrdHnvckBw\iCSRFfGMYlv\HWlZXSgVGRITlKjbIDoZUBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGmxNFE5KHKnc3nkeYUhcW5iaIXtZY4hVkOLLVixO|A{KGOnbHzzJIF1KDFidV2gZYZ1\XJiMjDodpMhcW5icILld4Vv[2Vib3[gVGRITi2DQTDifUBY\XO2ZYLuJIJtd3RiYX7hcJl{cXN? MmXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NESxOFkoRjJ7NUS0NVQ6RC:jPh?=
NCI-H1703 MlrQSpVv[3Srb36gZZN{[Xl? NYXSdJhLOSC3TR?= NVrhTGRUOiCqcoO= NEHhOYtKdmirYnn0bY9vKG:oIGDES2YucW6mdXPl[EBRTEeIUnHsdIhiKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVg1QSC{ZYPp[JVmKGmwIHj1cYFvKE6FST3INVcxOyClZXzsd{BifCBzIIXNJIFnfGW{IEKgbJJ{KGmwIIDy[ZNmdmOnIH;mJHBFT0ZvQVGgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
EOL-1 NUfiXoZCTnWwY4Tpc44h[XO|YYm= MkDFNUB2VQ>? M4THTVIhcHK| NFjROFVKdmirYnn0bY9vKG:oIGDES2ZT[WyyaHGgbY4hcHWvYX6gSW9NNTFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gV3RCXDVicHjvd5Bpd3K7bHH0bY9vKGG2IGm2PVQhemW|aXT1[UBifCBzIIXNJIFnfGW{IEKgbJJ{KGmwIIDy[ZNmdmOnIH;mJHBFT0ZvQVGgZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| M{jQWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NUS0NVQ6Lz5{OUW0OFE1QTxxYU6=
EOL-1 NInKNFBHfW6ldHnvckBie3OjeR?= M1rlPVEhfU1? MnnqNkBpenN? M3;JOmlvcGmkaYTpc44hd2ZiUFTHSnJidHCqYTDpckBpfW2jbjDFU2wuOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDFVmsheGixc4Doc5J6dGG2aX;uJIF1KFR{MEKvXVIxPCC{ZYPp[JVmeyCjdDCxJJVOKGGodHXyJFIhcHK|IHnuJJBz\XOnbnPlJI9nKFCGR1[tRWEh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV2NEG0PUc,Ojl3NESxOFk9N2F-
K562 MmrTSpVv[3Srb36gZZN{[Xl? M3\k[VEhfU1? NXX5d45XUW6qaXLpeIlwdiCxZjDCR3IuSUKOIHnuJIlu[XSrbnniMZNmdnOrdHn2[UBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFPyT2wheGixc4Doc5J6dGG2aX;uJIF1KDFidV2gZpkhcW2vdX7vJIJtd3RiYX7hcJl{cXN? M2fjbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMk[xOFY5Lz5|MEK2NVQ3QDxxYU6=
BA/F3 NYTMcXVOSW62aYT1cY9zKGG|c3H5 NUTsS442PTBibXevb4c> NWf0dllwOTRiZHH5dy=> M2nudmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFLBM2Y{KGOnbHzzJIV5eHKnc4Ppcochf2muZDD0fZBmKEKFUj3BRmwh[Wyub3fyZYZ1\WRiaX6gV2NKTCCvb4Xz[UBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHfyc5d1cCCjdDC1NEBu\y:tZzygdI8heWRiZn;yJFE1KGSjeYO= M1HQR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CxO|A{Lz5{M{OwNVcxOzxxYU6=
Ba/F3 MWLGeY5kfGmxbjDhd5NigQ>? MmXwNUBpeg>? NUj0N4ZHUW6qaXLpeIlwdiCxZjDCZ5IuSWKuIGSzNVVKKG23dHHueEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIH3veZNmKEKjL1[zJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCyaH;zdIhwenmuYYTl[EBUXEGWNTDs[ZZmdCCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? MmDwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEC4NFYoRjJ|NkCwPFA3RC:jPh?=
Ba/F3 MlTGSpVv[3Srb36gZZN{[Xl? NIrZd|cyKGi{ M2\ld2lvcGmkaYTpc44hd2ZiQnPyMWFjdCCWM{G1TUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCvb4Xz[UBD[S:IMzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGixc4Doc5J6dGG2ZXSgR5JsVCCuZY\lcEBi\nSncjCxJIhzKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMEiwOkc,OjN4MEC4NFY9N2F-
Ba/F3 M{DWV2Z2dmO2aX;uJIF{e2G7 NV7sVlZIOSCqch?= Ml;ETY5pcWKrdHnvckBw\iCEY4KtRYJtKFR|MUXJJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIIDoc5NxcG:{eXzheIlwdiC2cnHud4Zm[3SnZDDpckBud3W|ZTDCZU9HOyClZXzsd{Bi\nSncjCxJIhzKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMEiwOkc,OjN4MEC4NFY9N2F-
K562 MXzGeY5kfGmxbjDhd5NigQ>? MXK2JIhzew>? MVXJcohq[mm2aX;uJI9nKEKFUj3BRmwudWWmaXH0[YQhW1SDVEWgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiNjDodpMh[nlicHjvd5Bpdy2obH;3JIN6fG:vZYTyfS=> NHPVVVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG0PFU5PCd-MkKxOFg2QDR:L3G+
K562 MWLGeY5kfGmxbjDhd5NigQ>? MYq0NEB2VQ>? MnzXOkBpenN? MWnJcohq[mm2aX;uJI9nKEKFUj3BRmwudWWmaXH0[YQhTVKNMTDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iS{W2NkBk\WyuczDheEA1OCC3TTDh[pRmeiB4IHjyd{BjgSCyaH;zdIhwNW[ub4egZ5l1d22ndIL5 MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF2OEW4OEc,OjJzNEi1PFQ9N2F-
K562 MY\GeY5kfGmxbjDhd5NigQ>? NGDK[XA1OCC3TR?= MXi2JIhzew>? NUTicmdMUW6qaXLpeIlwdiCxZjDCR3IuSUKOLX3l[IlifGWmIFXST|IheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJGs2PjJiY3XscJMh[XRiNECgeW0h[W[2ZYKgOkBpenNiYomgdIhwe3Cqbz3mcI94KGO7dH;t[ZRzgQ>? M2[xelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUS4OVg1Lz5{MkG0PFU5PDxxYU6=
GISTT1 M2PmbWZ2dmO2aX;uJIF{e2G7 NXPaVnJtOSC3TR?= MnzENkBpenN? M3XwN2lvcGmkaYTpc44hd2ZiYz3LTXQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZO|E6KGmwIHj1cYFvKEeLU2TUNUBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n NWezWZB1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1 MV\GeY5kfGmxbjDhd5NigQ>? M1fhT|EhfU1? M2n5ZlIhcHK| MYLJcohq[mm2aX;uJI9nKGNvS1nUJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiWUiyN{BqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?= MnW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1 MWLGeY5kfGmxbjDhd5NigQ>? Mlr0NUB2VQ>? NFzjXIozKGi{cx?= M4HHfGlvcGmkaYTpc44hd2ZiYz3LTXQh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZO|A{KGmwIHj1cYFvKEeLU2TUNUBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n M3LxTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 Mlq0SpVv[3Srb36gZZN{[Xl? MUWxJJVO NWTtc5dYOiCqcoO= Mm\OTY5pcWKrdHnvckBw\iClLVvJWEBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGm4NlMhcW5iaIXtZY4hT0mVVEi4NkBk\WyuczDheEAyKHWPIH3lZZN2emWmIHHmeIVzKDJiaILzJIJ6KGmvbYXuc4Jtd3S2aX7n M2TCPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 NVT2ZlhZTnWwY4Tpc44h[XO|YYm= MorINUB2VQ>? NHTNPFQzKGi{cx?= NWrxVJNuUW6qaXLpeIlwdiCxZjDjMWtKXCCjdYTvdIhwe3Cqb4L5cIF1cW:wIHH0JHk4ODNiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{BifCBzIIXNJI1m[XO3cnXkJIFnfGW{IEKgbJJ{KGK7IHntcZVvd2Kub4T0bY5o NIjFZ2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882 MlHuSpVv[3Srb36gZZN{[Xl? Mn7iNUB2VQ>? M3vqb|IhcHK| NGXFUHpKdmirYnn0bY9vKG:oIHOtT2lVKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVcyQSCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> M33LVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 NWPxXJJ{TnWwY4Tpc44h[XO|YYm= NEj6OlMyKHWP MVKyJIhzew>? MnzTTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGFMXCCyaH;zdIhwenmuYYTpc44h[XRiU{S3N{BqdiCqdX3hckBIUVOWVEGgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?= MlvEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1 M{jXTmZ2dmO2aX;uJIF{e2G7 MX2xJJVO M2e2cVIhcHK| NXTIdGoxUW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFO2YYSzM|UheGixc4Doc5J6dGG2aX;uJIF1KFl5MEWvXVY6PCCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=> MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GISTT1 NHzyNHVHfW6ldHnvckBie3OjeR?= MVixJJVO NGDVSnAzKGi{cx?= MV3Jcohq[mm2aX;uJI9nKGNvS1nUJI1m\GmjdHXkJJNq\26jbHnu[{Bx[XSqd3H5d{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gSXJMOS9{IIDoc5NxcG:{eXzheIlwdiCjdDDUNlAzN1l{MESgbY4hcHWvYX6gS2lUXFRzIHPlcIx{KGG2IEGgeW0hdWWjc4Xy[YQh[W[2ZYKgNkBpenNiYomgbY1ufW6xYnzveJRqdmd? M4TCTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 Ml3TSpVv[3Srb36gZZN{[Xl? M2TmVFEhfU1? MkHjNkBpenN? M2HkUmlvcGmkaYTpc44hd2ZiYz3LTXQhdWWmaXH0[YQhe2mpbnHsbY5oKHCjdHj3ZZl{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBUPiCyaH;zdIhwenmuYYTpc44h[XRiU{KzOU8zOzZiaX6gbJVu[W5iR1nTWHQyKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882 MVHGeY5kfGmxbjDhd5NigQ>? MWCxJJVO M4P1blIhcHK| NF7VcYZKdmirYnn0bY9vKG:oIHOtT2lVKG2nZHnheIVlKHOrZ37hcIlv\yCyYYToe4F6eyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hWzZicHjvd5Bpd3K7bHH0bY9vKGG2IGOyN|UwOjN4IHnuJIh2dWGwIFfJV3Q5QDJiY3XscJMh[XRiMTD1UUBu\WG|dYLl[EBi\nSncjCyJIhzeyCkeTDpcY12dm:kbH;0eIlv\w>? NIXBO289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882 MnHFR4VtdCCleXPs[UBie3OjeR?= NFOweW4yKHWP MXu0PEBpenN? M1OwdmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IFewM2cyKHCqYYPlJIF1KDFidV2gZYZ1\XJiNEigbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVxUl7hd4Uhe3SjaX7pcoch[mG|ZXSg[oxwfyCleYTvcYV1enl? NFXwS|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
K562 Mln6RZBweHSxc3nzJIF{e2G7 NUfFRXFjOSC3TR?= NXj1WWp7UW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGOuZXH2ZYdmKG:oIGDBVnAh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MnfqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
K562 NVvs[5JjSXCxcITvd4l{KGG|c3H5 NF76XoYyKHWP NEPF[3pKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iY3zlZZZm\CClYYPwZZNmNTNibHX2[Ywh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= M4TGUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
K562 NIqzbYdE\WyuIHP5Z4xmKGG|c3H5 M{HqdVEhfU1? NVm4cXVrOjRiaILz M3zTTmNmdGxiY4njcIUh[XK{ZYP0JIlvKGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUwWk6jc3Wgd5RicW6rbnegZoF{\WRiZnzve{BkgXSxbXX0dpk> MnfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1 M{\oXGZ2dmO2aX;uJIF{e2G7 MYWxJJVO MXOyJIhzew>? NVzwOGtwUW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFN4SzDwbI9{eGixconsZZRqd25iYYSgWFM5QSCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZQhOSC3TTDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCrbX31co9jdG:2dHnu[y=> Ml7QQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
KU812 M2TaeWFxd3C2b4Ppd{Bie3OjeR?= NF3NclIyKHWP MkG3TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{BkdGWjdnHn[UBw\iCSQWLQJIF1KDFidV2gZpkhX2W|dHXyckBjdG:2IHHuZYx6e2m| NH\MNoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
GIST882 M1LiNWZ2dmO2aX;uJIF{e2G7 MVmxJJVO MoXSNkBpenN? NYnhT3QxUW6qaXLpeIlwdiCxZjDjMWtKXCCvZXTpZZRm\CC|aXfuZYxqdmdicHH0bJdigXNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKFO2YYSzM|UheGixc4Doc5J6dGG2aX;uJIF1KFl5MEWvXVY6PCCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF1KDFidV2gcYVie3W{ZXSgZYZ1\XJiMjDodpMh[nliaX3teY5w[myxdITpcoc> NFXLSpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2PCd-Mke5OlY6PTR:L3G+
KU812 Ml;0RZBweHSxc3nzJIF{e2G7 M1SzR|EhfU1? NFnZ[JNKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFvVPFEzKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPs[YF3\WRiY3HzdIF{\S1|IHzleoVtKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz NWrMWIdMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GIST882 M3nMSmZ2dmO2aX;uJIF{e2G7 NIPoc44yKHWP Mlq1NkBpenN? MkTrTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVTUzFxMjDwbI9{eGixconsZZRqd25iYYSgWFIxOi:\MkC0JIlvKGi3bXHuJGdKW1R6OEKgZ4VtdHNiYYSgNUB2VSCvZXHzeZJm\CCjZoTldkAzKGi{czDifUBqdW23bn;icI91fGmwZx?= M2q3[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 NV;TbGxFTnWwY4Tpc44h[XO|YYm= MYWxJJVO Ml7YNkBpenN? MlvaTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJHM3UyCyaH;zdIhwenmuYYTpc44h[XRiVEO4PUBqdiCqdX3hckBIUVOWOEiyJINmdGy|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne= MnjjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
KU812 M2nkfGNmdGxiY4njcIUh[XO|YYm= MlPVNUB2VQ>? M33FflEzKGi{cx?= MmnpR4VtdCCleXPs[UBienKnc4SgbY4hcHWvYX6gT3U5OTJiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFEhfU1iYX\0[ZIhOTJiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUwWk6jc3Wgd5RicW6rbnegZoF{\WRiZnzve{BkgXSxbXX0dpk> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
MEG01 NVfMXmJjSXCxcITvd4l{KGG|c3H5 NIjncIoyKHWP NIq4OIRKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIF3FS|AyKGOnbHzzJIF{e2W|c3XkJIF{KGOuZXH2ZYdmKG:oIGDBVnAh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= M3TxPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GISTT1 M2X3Z2Fxd3C2b4Ppd{Bie3OjeR?= NVP5NJM1OSC3TR?= NHfpfVBKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJIh2dWGwIFfJV3RVOSClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDQRXJRKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882 M{TtWmFxd3C2b4Ppd{Bie3OjeR?= NF3ZWlUyKHWP M{nxeGlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyClbHXheoFo\SCxZjDQRXJRKGG2IEGgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz M1PHRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882 M4n3UWFxd3C2b4Ppd{Bie3OjeR?= MnfhNUB2VQ>? M1rsd2lv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gbJVu[W5iR1nTWFg5OiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDjcIVifmWmIHPhd5Bie2VvMzDs[ZZmdCCjdDCxJJVOKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
MEG01 MUnD[YxtKGO7Y3zlJIF{e2G7 NX7kUXRtOSC3TR?= MYCyOEBpenN? MULD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDNSWcxOSClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzBxR{GgdIhie2ViYYSgNUB2VSCjZoTldkAzPCCqcoOgZpkheHKxcHnkbZVuKGmxZHnk[U9TVmG|ZTDzeIFqdmmwZzDiZZNm\CCobH;3JIN6fG:vZYTyfS=> NXz5O4pYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5OlY6PTRpPkK3PVY3QTV2PD;hQi=>
GISTT1 MkfXR4VtdCCleXPs[UBie3OjeR?= NUTzWowxOSC3TR?= NH[2[oIzPCCqcoO= MXjD[YxtKGO7Y3zlJIFzemW|dDDpckBpfW2jbjDHTXNVXDFiY3XscJMh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdyL1exJJBp[XOnIHH0JFEhfU1iYX\0[ZIhOjRiaILzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUwWk6jc3Wgd5RicW6rbnegZoF{\WRiZnzve{BkgXSxbXX0dpk> M{HPTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
MEG01 NEXVcmVCeG:ydH;zbZMh[XO|YYm= M4rw[VEhfU1? NVLk[lhvUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBpfW2jbjDNSWcxOSClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDjcIVifmWmIHPhd5Bie2VvMzDs[ZZmdCCjdDCxJJVOKGK7IGfld5Rmem5iYnzveEBidmGueYPpdy=> MmXyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7Nk[5OVQoRjJ5OU[2PVU1RC:jPh?=
GISTT1 MUfBdI9xfG:|aYOgZZN{[Xl? MXOxJJVO MlfCTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDoeY1idiCJSWPUWFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iY3zlZZZm\CClYYPwZZNmNTNibHX2[Ywh[XRiMTD1UUBjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl4Nkm1OEc,Ojd7Nk[5OVQ9N2F-
GIST882 MXfGeY5kfGmxbjDhd5NigQ>? NGDDbmwyKHWP MojZNkBpenN? MnLtTY5pcWKrdHnvckBw\iClLVvJWEBu\WSrYYTl[EB{cWewYXzpcocheGG2aIfhfZMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGFMXCCyaH;zdIhwenmuYYTpc44h[XRiU{S3N{BqdiCqdX3hckBIUVOWOEiyJINmdGy|IHH0JFEhfU1ibXXhd5Vz\WRiYX\0[ZIhOiCqcoOgZpkhcW2vdX7vZoxwfHSrbne= M1ntbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
LAMA-84 MWLHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NFu2[llKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMEezNFQh|ryPLh?= NUnKZ4xKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
EM-2 MnPuS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NGnLcotKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvODh6ODFOwG0v NVy0UVc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
MEG-01 NFjqcnlIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M{fvb2lvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAxNjB6OUKxJO69VS5? M4jDVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
BV-173 MXzHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NVW2eHNJUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwMUi3OEDPxE1w Mo\CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
K-562 NVzKdlFlT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= M1TnSWlvcGmkaYTpc44hd2ZiaIXtZY4hUy13NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvOjJ2M{Kg{txONg>? M{\wVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
CGTH-W-1 NXey[XpkT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NYDUZ3FlUW6qaXLpeIlwdiCxZjDoeY1idiCFR2TIMXcuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMD6zPFM4PCEQvF2u NID2[mU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
ST486 M2\LWGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MlTvTY5pcWKrdHnvckBw\iCqdX3hckBUXDR6NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNE43QDV2IN88UU4> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NCI-H1436 MXHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? MmrzTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG0N|Yh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDBwOUe4NFEh|ryPLh?= NYTxcWR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NOS-1 NYHvXnJRT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= M4DrOmlvcGmkaYTpc44hd2ZiaIXtZY4hVk:VLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFEvPjV|OEOg{txONg>? NHvpRmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
A498 M2DVW2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NEH0VXhKdmirYnn0bY9vKG:oIHj1cYFvKEF2OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFIvPTd{MkOg{txONg>? MmfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
BE-13 NVzKdG91T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NEfsR|lKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzNjZ{MUC2JO69VS5? Mmq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
SUP-T1 NUSzUph6T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MmDJTY5pcWKrdHnvckBw\iCqdX3hckBUXVBvVEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFMvQDJ7MEeg{txONg>? M1TU[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NCI-H1770 MWfHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? M{TEfmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|cxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB3LkW3NlYzKM7:TT6= M1TlRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
IMR-5 M1vv[mdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NYrvWnZUUW6qaXLpeIlwdiCxZjDoeY1idiCLTWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPi5{MkG0O{DPxE1w M4O1dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
LB2241-RCC MlLlS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? Mo\CTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB6LkC3N|g1KM7:TT6= Ml\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TGBC24TKB NHXqb41Iem:5dHigTY5pcWKrdHnvckBie3OjeR?= M{HIPGlvcGmkaYTpc44hd2ZiaIXtZY4hXEeEQ{K0WGtDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB6LkO0NFUzKM7:TT6= M1jYZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SCC-15 NE\oZ5dIem:5dHigTY5pcWKrdHnvckBie3OjeR?= Mm\wTY5pcWKrdHnvckBw\iCqdX3hckBUS0NvMUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFExNjd5OEig{txONg>? NXrwSFU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
BB49-HNC NF3ZWFlIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M1\KcmlvcGmkaYTpc44hd2ZiaIXtZY4hSkJ2OT3IUmMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF2LkOzN|Uh|ryPLh?= NHrqWmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
ES7 MmfTS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? Mne0TY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG0Mlc{PzlizszNMi=> NUjEOlRERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LB2518-MEL M4DYeGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 MVnJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF4Lk[wPVQh|ryPLh?= Mor5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NCI-H510A MU\Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NYDv[mdvUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUyOEFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG3MlI1PDJizszNMi=> NU[1b4NTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
TE-441-T MX;Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? M1rJVGlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNESxMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDF5LkK4PFYh|ryPLh?= NUHWSnJLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
HH NES0[YlIem:5dHigTY5pcWKrdHnvckBie3OjeR?= Mn:0TY5pcWKrdHnvckBw\iCqdX3hckBJUCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUeuN|k6QSEQvF2u MoK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LC4-1 M{LRc2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NVTOTFZIUW6qaXLpeIlwdiCxZjDoeY1idiCOQ{StNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOThwME[1NkDPxE1w NUjhcnZ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
KARPAS-45 MoPhS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NHTXenRKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iMUiuNVg1QCEQvF2u NFL5TpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LB1047-RCC Ml3XS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NXfLT2ZmUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCxPE41PDV{IN88UU4> M{Xxc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NKM-1 NI\v[HFIem:5dHigTY5pcWKrdHnvckBie3OjeR?= NV7OWI5PUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOTlwM{W1NkDPxE1w MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
SCLC-21H NFrRNYNIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M1Pjd2lvcGmkaYTpc44hd2ZiaIXtZY4hW0OOQz2yNWgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkGyOFYh|ryPLh?= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
RS4-11 Mm\TS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? M2Pae2lvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC5|M{C4JO69VS5? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
ALL-PO Ml7ZS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NWi0eZFKUW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkixOFkh|ryPLh?= NYDsZ2tZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
GDM-1 NXX3d2lYT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJGdFVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyNk42QTR3IN88UU4> NVrkSnZkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
DMS-79 Mn\US5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGROWy15OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNlQvPDl|NDFOwG0v MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MPP-89 MV7Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? MUPJcohq[mm2aX;uJI9nKGi3bXHuJG1RWC16OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNlUvPjh5NDFOwG0v NWfJZ5dQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NB10 M4ixNWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NXn1Z3J2UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPi52NzFOwG0v NGPpRoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
LS-513 NGjVTnJIem:5dHigTY5pcWKrdHnvckBie3OjeR?= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGxUNTVzMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gNlYvQDh2NzFOwG0v M1Ll[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
L-540 MorPS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? M3\yN2lvcGmkaYTpc44hd2ZiaIXtZY4hVC13NECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFI3NjlzNEOg{txONg>? M{Pn[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
ES1 NH7pc4dIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M4jmTGlvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTCyO{42OjFizszNMi=> MoTqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NTERA-S-cl-D1 M3TLbWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NHPBUG1KdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFMxNjVyOUOg{txONg>? M3;xOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-1 NH;0UGVIem:5dHigTY5pcWKrdHnvckBie3OjeR?= M{n5dGlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gN|IvQTR3NDFOwG0v NYPDV4xvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
Calu-6 NXXEfVJ6T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= NH;CRmtKdmirYnn0bY9vKG:oIHj1cYFvKEOjbIWtOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzNwMUi1OUDPxE1w MlGxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
CTV-1 MXXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? Ml\YTY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gN|MvQTd6OTFOwG0v NYCyWpZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
YT M3;Xb2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 Mor0TY5pcWKrdHnvckBw\iCqdX3hckB[XCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iM{iuOVIxQSEQvF2u M4m5elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-6 NVPNZYR3T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= M3zLWmlvcGmkaYTpc44hd2ZiaIXtZY4hXEVvNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFEvOjd7NzFOwG0v MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
HT-144 M3nIWmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 M4rxSmlvcGmkaYTpc44hd2ZiaIXtZY4hUFRvMUS0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1OS53NEi2JO69VS5? M4jYT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-13 MUXHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>? NULPU3doUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDJwMke5NUDPxE1w NUH6Xpk2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
KALS-1 Ml7XS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? NGH5UJNKdmirYnn0bY9vKG:oIHj1cYFvKEuDTGOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDNwMUOyPEDPxE1w M3;yT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
MOLT-16 M3[zcWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7 NIraeVhKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR3LkC3OVIh|ryPLh?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
D-336MG MoTqS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2Njl3OUmg{txONg>? MnnyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
TE-11 NXXhe4RTT3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= M3XJV2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ3MzFOwG0v MlnoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
EB2 NUmyelg{T3Kxd4ToJGlvcGmkaYTpc44h[XO|YYm= MXnJcohq[mm2aX;uJI9nKGi3bXHuJGVDOiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iNE[uOlk6KM7:TT6= M1HvPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SK-N-DZ MorpS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? M3nNPGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTj3EXkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDhwMEm2NUDPxE1w M36zNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SW684 M3jJU2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7 M1LaRmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjJ4OUWg{txONg>? NFL5PWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
EW-18 MkLhS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTF6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0PE41Ozl3IN88UU4> M1jaZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / p-STAT5 / STAT5; 

PubMed: 18981115     


For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖

p-ZAP70 / ZAP70 / p-LAT / LAT; 

PubMed: 18981115     


For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 

18981115
Immunofluorescence
RelB; 

PubMed: 20371728     


Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry 

Cortactin / F-actin; 

PubMed: 20937825     


NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜

20371728 20937825
Growth inhibition assay
Cell viability ; 

PubMed: 28435223     


(C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺

28435223
In vivo Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. [5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. [6]

Protocol

Kinase Assay:[1]
- Collapse

PDGF receptor kinase activity:

PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl2). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-33P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:[3]
- Collapse
  • Cell lines: BON-1 cells and NCI-H727 cells
  • Concentrations: ~100 μM
  • Incubation Time: 48 hours
  • Method: BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively.
    (Only for Reference)
Animal Research:[5]
- Collapse
  • Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female).
  • Dosages: 70 or 100 mg/kg
  • Administration: Administered via i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 118 mg/mL (200.09 mM)
Water 118 mg/mL (200.09 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 589.71
Formula

C29H31N7O.CH4SO3

CAS No. 220127-57-1
Storage powder
in solvent
Synonyms Gleevec, Glivec, CGP-57148B
Smiles CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02687425 Unknown status Drug: Pioglitazone|Drug: imatinib mesylate Leukemia Myelogenous Chronic BCR-ABL Positive Meng Li|Tongji Hospital February 2016 Phase 2
NCT02303899 Completed Drug: Gemcitabine|Drug: Imatinib mesylate Mesothelioma Malignant Istituto Clinico Humanitas November 2014 Phase 2
NCT01898377 Terminated Drug: Imatinib mesylate Mycophenolate mofetil Chronic Graft-versus-host Disease Seoul National University Hospital August 2013 Phase 2
NCT02891395 Completed Drug: Imatinib Mesylate and Nilotinib Graft Versus Host Disease University Hospital Lille|Novartis December 24 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

Related Bcr-Abl Products

Tags: buy Imatinib (STI571) Mesylate | Imatinib (STI571) Mesylate supplier | purchase Imatinib (STI571) Mesylate | Imatinib (STI571) Mesylate cost | Imatinib (STI571) Mesylate manufacturer | order Imatinib (STI571) Mesylate | Imatinib (STI571) Mesylate distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID