Imatinib (STI571) Mesylate

Name: Imatinib (STI571) Mesylate
Brand: Selleck Chemicals
SKU: S1026
Rating: 5 (176 reviews)

For research use only.

Catalog No.S1026 Synonyms: Gleevec, Glivec, CGP-57148B

176 publications

Imatinib (STI571) Mesylate Chemical Structure

CAS No. 220127-57-1

Imatinib (STI571, CGP057148B, Gleevec) Mesylate is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively. Imatinib Mesylate (STI571) induces autophagy.

Selleck's Imatinib (STI571) Mesylate has been cited by 176 publications

Science, 2020, 370(6513)eabc2754

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Cell Stem Cell, 2020, 10;S1934-5909(20)30144-2

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Cell Metab, 2018, 28(6):817-832

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Cancer Cell, 2014, 26(6):840-50

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Cell Stem Cell, 2012, 10(2):210-7

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Cell Death Dis, 2021, 12(5):456

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Cell Death Discov, 2021, 7(1):139

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Hum Mol Genet, 2021, ddab011

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Hum Mol Genet, 2021, ddab014

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Cancer Sci, 2021, 112(2):655-667

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Biochem Pharmacol, 2021, 190:114658

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Invest New Drugs, 2021, 10.1007/s10637-020-01028-8

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Ann Hematol, 2021, 10.1007/s00277-020-04357-z

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PLoS One, 2021, 16(7):e0250442

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Blood, 2020, 8 pii: blood

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Clin Cancer Res, 2020, 21;clincanres31422019

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Genome Med, 2020, 18;12(1):17

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Cancer Res, 2020, canres.1992.2020

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Cell Rep, 2020, 24;30(12):3951-3963 e4

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J Hematol Oncol, 2020, 13(1):80

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Cancers (Basel), 2020, 25;12(5)

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Cancers (Basel), 2020, 13;12(2) pii: E436

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Cancers (Basel), 2020, 12(6):E1674

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PLoS Pathog, 2020, 16(8):e1008823

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Br J Cancer, 2020, 10.1038/s41416-020-0952-1

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Aging (Albany NY), 2020, 12(17):17662-17680

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Front Bioeng Biotechnol, 2020, 20;8:482

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Cancer Sci, 2020, 10.1111/cas.14750

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Front Oncol, 2020, 12;10:696

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J Cell Mol Med, 2020, 10.1111/jcmm.15830

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Int J Mol Sci, 2020, 21(1)

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Sci Rep, 2020, 10(1):11269

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Cancer Cell Int, 2020, 19;20:58

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Oncol Rep, 2020, 44(5):2152-2164

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Drug Des Devel Ther, 2020, 12;14:1799-1811

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J Pharm Biomed Anal, 2020, 195:113864

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J Mol Neurosci, 2020, 10.1007/s12031-020-01735-0

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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FEBS Open Bio, 2020, 10.1002/2211-5463.13052

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bioRxiv, 2020, 2020/9/20.4.7.30734

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Immun Inflamm Dis, 2020, 10.1002/iid3.383

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Biochem Biophys Res Commun, 2020, 529(3):699-706

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Ann N Y Acad Sci, 2020, 1467(1):77-93

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J Cell Mol Med, 2020, 10.1111/jcmm.15612

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J Pers Med, 2020, 10(4)E234

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Hemasphere, 2020, 4(6):e497

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Neoplasia, 2020, 22(10):470-483

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Cold Spring Harb Mol Case Stud, 2020, mcs.a005710

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Nat Cell Biol, 2019, 21(6):778-790

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Mol Cell, 2019, 75(2):252-266

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Autophagy, 2019, 15(12):2076-2090

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Cell Rep, 2019, 29(13):4471-4481.e6

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Elife, 2019, 8e48725

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J Exp Clin Cancer Res, 2019, 18;38(1):85

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Cancers (Basel), 2019, 11(12)E2043

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Gastric Cancer, 2019, 10.1007/s10120-019-00977-1

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Hum Reprod, 2019, 34(3):506-518

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J Cell Mol Med, 2019, 23(12):8314-8327

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Sci Rep, 2019, 9(1):1897

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Eur J Pharmacol, 2019, 17:172559

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PLoS One, 2019, 14(10):e0224237

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Int J Med Sci, 2019, 16(8):1149-1156

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Cancer Invest, 2019, 37(2):99-112

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Res Vet Sci, 2019, 124:1-9

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JCI Insight, 2019, 4(23)131434

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Front Immunol, 2019, 10:1876

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Nat Biomed Eng, 2018, 2(8):578-588

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Sci Transl Med, 2018, 10(427)

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Acta Neuropathol, 2018, 135(5):779-798

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Blood, 2018, 131(14):1532-1544

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Clin Cancer Res, 2018, 1;24(1):145-157

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Cell Rep, 2018, 23(11):3127-3136

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Elife, 2018, 7e36656

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J Exp Clin Cancer Res, 2018, 25;37(1):170

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Cell Death Discov, 2018, 4:48

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Front Immunol, 2018,

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Endocr Relat Cancer, 2018, 25(4):471-480

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Neoplasia, 2018, 20(8):857-870

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Pharmacol Res, 2018, 133:121-131

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Eur J Med Chem, 2018, 154:101-109

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Cancer Sci, 2018, 109(9):2792-2800

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J Cell Physiol, 2018, 233(9):7467-7479

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J Cell Sci, 2018,

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Biochem Pharmacol, 2018, 10.1016/j.bcp.2018.10.011

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Toxicol Sci, 2018, 165(1):232-243

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Biomed Pharmacother, 2018, 106:403-410

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Cell Signal, 2018, 51:191-198

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PLoS One, 2018, 13(2):e0191890

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Biochem Biophys Res Commun, 2018, 502(1):110-115

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Int J Clin Exp Pathol, 2018, 11(1):179-188

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Hemasphere, 2018, 2(3):e41

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NPJ Syst Biol Appl, 2018, 4:1

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Nat Commun, 2017, 1;8(1):1232

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Dev Cell, 2017, 42(2):117-129

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Theranostics, 2017, 7(5):1333-1345

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Cancer Res, 2017, 77(5):1142-1154

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Cell Rep, 2017,

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Cancer Lett, 2017, 393:113-124

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Cell Death Dis, 2017, 8(10):e3117

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Arch Toxicol, 2017, 91(8):2921-2938

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Mol Cancer Ther, 2017, 16(4):671-680

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Sci Rep, 2017,

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Exp Cell Res, 2017, 353(2):72-78

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BMC Cancer, 2017,

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Bioconjug Chem, 2017, 28(10):2608-2619

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Molecules, 2017, 22(12)

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Leuk Lymphoma, 2017, 58(8):1903-1913

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Reprod Fertil Dev, 2017, 29(7):1356-1368

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Oncotarget, 2017, 8(54):91841-91859

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Zhonghua Xue Ye Xue Za Zhi, 2017, 38(12):1036-1042

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Oncotarget, 2017, 8(27):43662-43677

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Cell Stem Cell, 2017, 20(2):233-246

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Cell, 2017, 170(3):507-521

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Blood, 2016, 28;127(17):2131-43

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Hepatology, 2016, 64(2):488-500

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EMBO Mol Med, 2016, 1;8(2):105-16

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Stem Cell Res, 2016, 16(3):795-806

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Mol Cancer Ther, 2016, 15(10):2302-2313

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Mol Cancer Ther, 2016, 15(1):94-105

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Mol Pharm, 2016, 13(10):3457-3467

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Traffic, 2016, 17(4):351-68

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Cancer Sci, 2016, 107(6):782-90

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Transl Oncol, 2016, 9(6):540-547

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Oncol Rep, 2016, 35(1):197-204

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Mol Vis, 2016, 22:1213-1220

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Oncotarget, 2016, 7(29):45916-45925

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Oncotarget, 2016, 7(18):26709-23

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Nat Commun, 2015, 6:7002

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J Clin Invest, 2015, 125(6):2317-34

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Nat Commun, 2015, 6:8481

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Genes Dev, 2015, 29(7):732-45

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Cell Rep, 2015, 10.1016/j.celrep.2015.05.012

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J Urol, 2015, 194(6):1797-805

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Phytother Res, 2015, 29(7):1062-72

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Phytother Res, 2015, 29(3):434-43

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PLoS One, 2015, 10(3):e0120531

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Biomed Res Int, 2015, 2015:368976

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Oncol Lett, 2015, 10(5):2835-2841

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Brain Behav, 2015, 3;5(11):e00359

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Sci Transl Med, 2014, 6(261):261ra152

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Nat Protoc, 2014, 10(1):149-68

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J Clin Invest, 2014, 124(8):3378-90

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Leukemia, 2014, 28(4):977-9

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Oncogene, 2014, 33(2):236-45

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Stem Cells, 2014, 32(9):2324-37

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Mol Cancer Ther, 2014, 13(10):2276-87

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Cancer Cell Int, 2014, 14(1):89

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Int J Oncol, 2014, 44(5):1661-8

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J Alzheimers Dis, 2014, 41(3):729-37

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PLoS One, 2014, 9(10):e109441

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Biochem Biophys Res Commun, 2014, 450(4):1600-5

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Biomed Res Int, 2014, 2014:682010

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Graefes Arch Clin Exp Ophthalmol, 2014, 10.1007/s00417-014-2674-7

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University of Alberta, 2014, Yahya Muhammad Fiteih

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Cancer Immunol Res, 2014, 2(12):1186-98

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Cancer Res, 2013, 73(12):3661-70

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Pigment Cell Melanoma Res, 2013, 26(4):518-26

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J Mol Cell Cardiol, 2013, 66:177-88

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J Biol Chem, 2013, 288(34):24503-17

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Drug Metab Dispos, 2013, 10.1124/dmd.113.054189

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Proteomics, 2013, 13(23-24):3554-62

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Leuk Res, 2013, 37(11):1532-7

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Sci Transl Med, 2012, 4(131):131ra50

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Leukemia, 2012, 27(4):932-40

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J Invest Dermatol, 2012, 132(7):1850-9

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Biochemistry, 2012, 51(25):5153-9

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PLoS One, 2012, 7(8):e42310

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Exp Hematol, 2012, 41(4):335-45.e3

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Leuk Res, 2012, 37(2):183-9

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Anticancer Res, 2012, 33(1):175-81

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FASEB J, 2011, 25(10):3661-73

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Pharm Res, 2011, 28(2):337-63

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PLoS One, 2010, 5(11):e14143

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Purity & Quality Control

Choose Selective Bcr-Abl Inhibitors

Biological Activity

Description

Targets

PDGFR ^[1] (Cell-free assay)	c-Kit ^[2] (M-07e cells)	v-Abl ^[1] (Cell-free assay)
100 nM	100 nM	600 nM

In vitro

In vitro assays for inhibition of a panel of tyrosine and serine/threonine protein kinases show that Imatinib inhibits the v-Abl tyrosine kinase and PDGFR potently with an IC50 of 0.6 and 0.1 μM, respectively. ^[1] Imatinib inhibits the SLF-dependent activation of wild-type c-kit kinase activity with a IC50 for these effects of approximately 0.1 μM, which is similar to the concentration required for inhibition of PDGFR. ^[2] Imatinib exhibits growth-inhibitory activity on the human bronchial carcinoid cell line NCI-H727 and the human pancreatic carcinoid cell line BON-1 with an IC50 of 32.4 and 32.8 μM, respectively. ^[3] A recent study shows that Imatinib has the potential to exert its antileukemia effects in chronic myelogenous leukemia by down-regulating hERG1 K(+) channels, which are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
GIST882	M{LRbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoTsPVYhcA>?	MV\JR\|UxRTFwNzFOwG0>	NYfRdZpURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFAzOTJpPkK0PVAxOjF{PD;hQi=>
K562	MoTRR5l1d3SxeHnjbZR6KEG\|c3H5		MUSyOEBp	M17zWGlEPTB;MD6yNUDPxE1?	M1j5O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MECwNlA4Lz5{MkCwNFIxPzxxYU6=
MCF-7	MU\DfZRwfG:6aXPpeJkhSXO\|YYm=		MUiyOEBp	MYrJR\|UxRTBwOEOg{txO	Mk[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyMECyNFcoRjJ{MECwNlA4RC:jPh?=
MDA-MB-23	M1zsVmN6fG:2b4jpZ4l1gSCDc4PhfS=>		M3HifVI1KGh?	NHqySIZKSzVyPUGuPEDPxE1?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjByMEKwO{c,OjJyMECyNFc9N2F-
K562r	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MUDJR\|UxRTFywrFOwG0>	NH;lZVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmzPVQyQCd-MkS5N\|k1OTh:L3G+
K562	NX7rXY9ET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			M3;lWWVEPTB;MD6wPUDPxE1?	M1rsdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4Nke4OFE1Lz5zNk[3PFQyPDxxYU6=
MCF-7	NHTxTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXFdGYyOCEQvF2=	M1PnVlQ5KGh?	MVzicI9kc3NiY3XscEBxem:uaX\ldoF1cW:wIHnuZ5Jm[XOnIHnu[JVk\WRiYomgRmo{Yg>?	MknwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{N{SwN\|QoRjJ3Mke0NFM1RC:jPh?=
K-562	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			M3\ncGlEPTB;MTFOwG0>	MoDLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{M{m2OlIoRjJ3MkO5OlYzRC:jPh?=
K562	NH21UoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			MlnhTWM2OD1yLkZCpO69VQ>?	MmTFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7M{m0NVgoRjJ2OUO5OFE5RC:jPh?=
PC3	MofaRZBweHSxc3nzJGF{e2G7	NGjmWoYzOOLCid88US=>	M3XoU\|Q5Nzd{IHi=	MWDpcoNz\WG\|ZYOgZ4VtdCC\|dYL2bZZidA>?	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd6Nk[1Okc,OjV5OE[2OVY9N2F-
PC3	NFu0dllE\WyuIG\pZYJqdGm2eTDBd5NigQ>?	NWLIdm5JOjEkgJpOwG0>	MVO2MVczKGh?	NIjWRpBqdmO{ZXHz[ZMh[2WubDD2bYFjcWyrdIm=	NXLaeopHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PFY3PTZpPkK1O\|g3PjV4PD;hQi=>
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GIST882	MlftSpVv[3Srb36gZZN{[Xl?			NVHreHB[UW6qaXLpeIlwdiCxZjDoeY1idiCNSWSgZZV1d3Cqb4PwbI9zgWyjdHnvckBqdiCqdX3hckBIUVOWOEiyJINmdGy\|IHL5JGVNUVODLDDJR\|UxKD1iMD6wPVch\|ryPLh?=	NVPCc2ZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
GIST882	MYTGeY5kfGmxbjDhd5NigQ>?			NIrBNnZKdmirYnn0bY9vKG:oIFvJWEBMPjR{RTDteZRidnRiYYX0c5Bpd3OyaH;yfYxifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDHTXNVQDh{IHPlcIx{KGK7IFXMTXNCNCCLQ{WwJF0hOC5yOUeg{txONg>?	NXXB[lJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2NVE4PzFpPkKzOlEyPzdzPD;hQi=>
insect	MorVSpVv[3Srb36gZZN{[Xl?		NX\uV\|g4OzBibXnudy=>	Mo\kTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCC5aXzkJJR6eGViQVLMNUBmgHC{ZYPz[YQhcW5iaX7z[YN1KGOnbHzzJIFnfGW{IEOwJI1qdnNiYomgSnJGXCCjc4PhfUwhUUN3MDC9JFAvODl6MjFOwG0v	NX7XR5BKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	M{TJ[GN6fG:2b4jpZ4l1gSCjc4PhfS=>		M3fwOFczKGi{cx?=	M2XzVmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JIFt[W2jcj3icJVmKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMD6xJO69VS5?	NYi3SGpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzNFE6ODJpPkG5N\|AyQTB{PD;hQi=>
primary leukemia cells	MoTtR5l1d3SxeHnjbZR6KGG\|c3H5		M17WV\|czKGi{cx?=	MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5Nqdmdid3ns[EB1gXCnIF\MWFMh[XO\|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[W[2ZYKgO\|IhcHK\|IHL5JIx2[2moZYLhd4Uh[XO\|YYmsJGlEPTBiPTCwMlEh\|ryPLh?=	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ{MUKwNUc,OjJ{MkGyNFE9N2F-
BV173	NGn1TlVCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		M4PyNVQ5KGi{cx?=	NF;4NHhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLWNVc{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDD[YxtNVSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhT0l3MDC9JFAvOSEQvF2u	NVPBTJJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewNVEyPTlpPkK3NFEyOTV7PD;hQi=>
BAF3	MYHGeY5kfGmxbjDhd5NigQ>?		MlS0O\|IhcHK\|	NGjmd3VKdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDjT2lVKEx3NkfQJI12fGGwdDCoeY5sdm:5bjDvdolocW5rIITyZY5{\mWldHXkJIlvKG2xdYPlJGJCTjNiY3XscJMh[XO\|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkGg{txONg>?	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
K562	M3\4[GN6fG:2b4jpZ4l1gSCjc4PhfS=>		NYDzPZhWOjRiaILz	MYXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlEh\|ryPLh?=	MkLkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4M{K5N\|UoRjJ{NkOyPVM2RC:jPh?=
BA/F3	MV7GeY5kfGmxbjDhd5NigQ>?		M4PFS\|czKGi{cx?=	MkLNTY5pcWKrdHnvckBw\iCWRVyt[pV{\WRiUFTHSnJj\XSjIDj1cotvd3ewIH;ybYdqdilidILhcpNn\WO2ZXSgbY4hdW:3c3WgRmEwTjNiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBk\WyuIHfyc5d1cCCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBOXFNiYYPzZZktKEeLNUCgQUAxNjFyMjFOwG0v	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BAF3	NYP4fpRoTnWwY4Tpc44h[XO\|YYm=		M3jJ[lczKGi{cx?=	NUDRSFJDUW6qaXLpeIlwdiCxZjDU[Ywu\nW\|ZXSgZ{1MUVRiTEW3OnAhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKEKDRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gcYVie3W{ZXSgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLPEBie3OjeTygS2k2OCB;IECuNVAzKM7:TT6=	M{f6SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
GIST882	MYXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			M1K0ZWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iR1nTWFg5OiClZXzsd{whUUN3MDC9JFAvOTB6IN88UU4>	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
GIST882	M{jubWZ2dmO2aX;uJIF{e2G7			M{jCeGlvcGmkaYTpc44hd2ZiS1nUJGs3PDKHIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDoeY1idiCJSWPUPFgzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZpkhSVSSLXTldIxmfGmxbjDhd5NigSxiSVO1NEA:KDBwMUC4JO69VS5?	NHKxfYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xNVc4OSd-MkO2NVE4PzF:L3G+
K562	NHGzV\|FEgXSxdH;4bYNqfHliYYPzZZk>			Mn7tR5l1d3SxeHnjJIVn\mWldDDpckBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC5zMTFOwG0v	NFT6W\|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkm1NVEyOyd-MUK5OVEyOTN:L3G+
KU812	MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MVu3NkBpenN?	MkfqRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNVUixNkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuIHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSClZXzsJJRqfGW{LXfsc{Bie3OjeTygS2k2OCB;IECuNVEh\|ryPLh?=	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV2MU[5OUc,Ojh3NEG2PVU9N2F-
BA/F3	NHr1[3hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		NHztbmk4OiCqcoO=	M3G0bWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViQlGvSlMh[2WubIOg[ZhxemW\|c3nu[{BD[3JvQXLsJGg{QT[SIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhS0ONLUigZZN{[XluIFnDOVAhRSByLkGxJO69VS5?	MoC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
BAF3	MWjGeY5kfGmxbjDhd5NigQ>?		NE\YWIU4OiCqcoO=	NEnsSG9KdmirYnn0bY9vKG:oIGTlcE1nfXOnZDDDV2YyWiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDCRWY{KGOnbHzzJIF{e2W\|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKG2nYYP1doVlKGGodHXyJFczKGi{czDifUBE\WyuVHn0[ZIuT2yxIH;yJGNEUzhiYYPzZZktKEeLNUCgQUAxNjFzIN88UU4>	M4C3b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OU[2PVU1Lz5{N{m2Olk2PDxxYU6=
32D	NU\kS204SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=		M2SwT\|Q5KGi{cx?=	NHHYd5pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIEOySEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIICyNVAh[2WubIOg[ZhxemW\|c3nu[{BD[3JvYXLsJIF{e2W\|c3XkJIF{KHC{b3zp[oVz[XSrb36gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuNVEzKM7:TT6=	M1fNcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
insect cells	MUHGeY5kfGmxbjDhd5NigQ>?		MYezNEBucW6\|	NEn6ZWNKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhVTN3MWSgcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD6xNVQ{KM7:TT6=	NE\QZ4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
insect cells	NUO1V3FjTnWwY4Tpc44h[XO\|YYm=		MWqzNEBucW6\|	NETyeGhKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFHCUFEhWTJ3MligcZV1[W62IHX4dJJme3OnZDDpckBqdnOnY4SgZ4VtdHNiYX\0[ZIhOzBibXnud{BjgSCIUlXUJIF{e2G7LDDJR\|UxKD1iMD6xNVUh\|ryPLh?=	NX3Wem9MRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFE4ODNpPkKzN\|AyPzB\|PD;hQi=>
K562	NE\HS5FCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=		MnXBO\|IhcHK\|	MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLDVk1CSkxiZHXw[Y5l\W62IHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JIFnfGW{IEeyJIhzeyCkeTDj[YxtfGm2ZYKt[4xwN0OFS{igZZN{[XluIFfJOVAhRSByLkGyJO69VS5?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{ewOUc,OjdyN{e3NFU9N2F-
BA/F3	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		MUm3NkBpenN?	MnHWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2DYnygUVI1PFZibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwMUK5JO69VS5?	M{PqWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MEi4OlQ1Lz5{M{C4PFY1PDxxYU6=
K562	MoSwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NVzHSFByPzJiaILz	MlT6RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDoeY1idiCNNU[yJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJI9zKEOFSz24JIF{e2G7LDDHTVUxKD1iMD6xOEDPxE1w	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
HEK293	MWnGeY5kfGmxbjDhd5NigQ>?			MnzvTY5pcWKrdHnvckBw\iCjdYTvdIhwe3Cqb4L5cIF1cW:wIH;mJGRFWjJiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMUSxJO69VS5?	NWHaPFhZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4NVc2OzhpPkKwPFE4PTN6PD;hQi=>
K562	M4K0bmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M2K2SlczKGi{cx?=	NX3lWplHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W\|c3XkJIF{KGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IHPlcIwhfGm2ZYKt[4xwKGG\|c3H5MEBIUTVyIE2gNE4yPDdizszNMi=>	NXrvT4RDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki1OFE3QTVpPkK4OVQyPjl3PD;hQi=>
BAF3	NFvp[IhHfW6ldHnvckBie3OjeR?=		NXTnZ5hiPzJiaILz	MVfJcohq[mm2aX;uJI9nKFSHTD3meZNm\CClS1nUJGE5OjmSIH31eIFvfCBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDtc5V{\SCEQV[zJINmdGy\|IHHzd4V{e2WmIHHzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOnbHygeIl1\XJvZ3zvJIF{e2G7LDDHTVUxKD1iMD6xOFgzKM7:TT6=	NEf1WpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW0NVY6PSd-Mki1OFE3QTV:L3G+
Ba/F3	M3vjTWZ2dmO2aX;uJIF{e2G7		NUHERm9{PDhiaILz	NVvNbm92UW6qaXLpeIlwdiCxZjDCR3IuSUKOMTDFN\|U2TyCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSmFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCEQ2KtRWJNOS2vZXTpZZRm\CClZXzsJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{aYTlUIlocHRibIXjbYZmemG\|ZTDhd5NigSxiR1m1NEA:KDBwMUS5JO69VS5?	M{ntZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUO3PVgyLz5\|MEGzO\|k5OTxxYU6=
KU812	MlTuRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		MmDMO\|IhcHK\|	M1rKN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS2W4NVIh[2WubIOgZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlE3KM7:TT6=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjd6OUW1N{c,OjZ5OEm1OVM9N2F-
KU812	MorKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NInvNHE4OiCqcoO=	MYHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLDVk1CSkxiZHXw[Y5l\W62IHj1cYFvKEuXOEGyJINmdGy\|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgZ4VtdHSrdHXyMYdtdy:FQ1u4JIF{e2G7LDDHTVUxKD1iMD6xOkDPxE1w	M2nYdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3O\|A2Lz5{N{C3O\|cxPTxxYU6=
A10	NXv1OXl2TnWwY4Tpc44h[XO\|YYm=		NF3mZms3QCCqcoO=	M1fO[2lvcGmkaYTpc44hd2ZiUFTHSnIu[mW2YTDkdol3\W5icILvcIln\XKjdHnvckBw\iC{YYSgRVExKGOnbHzzJIFnfGW{IE[4JIhzeyCrbjDwdoV{\W6lZTDv[kBz[XRicnXjc41jcW6jboSgVGRITi2EQjDifUBk\WyuIITpeIVzNWeubzDseY1qdmW\|Y3XuZ4Uh[XO\|YYmsJGlEPTBiPTCwMlE3OiEQvF2u	NIXJdmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{WwNlcxOCd-Mke1NFI4ODB:L3G+
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K562	MVXDfZRwfG:6aXPpeJkh[XO\|YYm=		M1X5NlczKGi{cx?=	M2fETmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgO\|IhcHK\|IHL5JG1VWyCjc4PhfUwhT0l3MDC9JFAvOzlizszNMi=>	MlTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7M{KzNVMoRjJ{OUOyN\|E{RC:jPh?=
BA/F3	MY\GeY5kfGmxbjDhd5NigQ>?		MljFO\|IhcHK\|	M3P6ZWlvcGmkaYTpc44hd2ZiS3n0JIV5d25iMUGg[IVt\XSrb36gLFU2PyC2bzC1OVghemW\|aXT1[ZMqKGGwZDDWOlU1SSCvdYThcpQhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCEQT;GN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IF3UV{Bie3OjeTygS2k2OCB;IECuN\|kzKM7:TT6=	NHnNW3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEKwOFQ1OSd-M{CyNFQ1PDF:L3G+
BA/F3	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?	M2fsXFUhfG9iMUCgeW0>	MYe0PEBpenN?	MlL4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJG5RVS2jYnygZZN{\XO\|ZXSgZZMh[2WubDD2bYFjcWyrdImgZZQhPSC2bzCxNEB2VSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5\|OUOg{txONg>?	M1;kXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEG1PFY{Lz5zNkSxOVg3OzxxYU6=
K562	M2LNVWZ2dmO2aX;uJIF{e2G7			NWDaSmhRUW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh\3Kxd4ToJJV{cW6pIF3UWEBie3OjeTygTWM2OCB;IECuOEDPxE1w	MoLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR3NUK3OlAoRjF2NUWyO\|YxRC:jPh?=
BAF3	MWrGeY5kfGmxbjDhd5NigQ>?		MnnSO\|IhcHK\|	MVrJcohq[mm2aX;uJI9nKFSnbD3meZNm\CClS1nUJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkGIMzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG\|ZTDpckBk\WyuIIDyc4xq\mW{YYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JINmdGy2aYTldk1odG9xQ1PLPEBie3OjeTygS2k2OCB;IECuOEDPxE1w	NYPHOVR5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|c4ODVpPkK3NFc4PzB3PD;hQi=>
BA/F3	Mlr1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		NV7ucotsPzJiaILz	Moj1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6\|dDDtc5V{\SCEQT;GN{Bk\WyuczDlfJBz\XO\|aX7nJGJkei2DYnygUVM2OVRibYX0ZY51KGGodHXyJFczKGi{czDifUBES0tvODDhd5NigSxiSVO1NEA:KDBwNEK0JO69VS5?	MkT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyOEi2OFQoRjJ\|MEi4OlQ1RC:jPh?=
KCL22	MWDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?		NUfac3MzPDhiaILz	NV\UPFlMSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLR2wzOiClZXzsd{Bi\nSncjC0PEBpenNiYomgR4VtdC2WaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEeLNUCgQUAxNjR\|IN88UU4>	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzBzMUG1PUc,OjdyMUGxOVk9N2F-
Ba/F3	MoDiSpVv[3Srb36gZZN{[Xl?		NYjIXVV7PDhiaILz	M1noTmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiUUK1NmghdXW2YX70JEh2dmuwb4fuJI9zcWerbjmg[ZhxemW\|c3XkJIlvKG2xdYPlJGJiN0Z\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhSkOULVHCUFEudWWmaXH0[YQh[2WubDDwdo9tcW[ncnH0bY9vKGGodHXyJFQ5KGi{czDifUBDemm2ZVzp[4h1KGy3Y3nm[ZJie2ViYYPzZZktKEeLNUCgQUAxNjR3NTFOwG0v	NH;4fmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEGzO\|k5OSd-M{CxN\|c6QDF:L3G+
Sf9	MXrGeY5kfGmxbjDhd5NigQ>?			M3jrfGlvcGmkaYTpc44hd2ZiaIXtZY4hSWKuIHvpcoF{\SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzMEBKSzVyIE2gNE41PyEQvF2u	NWTFTmh[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUezO\|Y3QDBpPkG3N\|c3PjhyPD;hQi=>
K562	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=		NVLxfFl2PDhiaILz	NUDTeFY2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD60O{DPxE1w	MlPMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5M{W4NlYoRjJ\|N{O1PFI3RC:jPh?=
K562	MoXDRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?		M1PGdlQ5KGi{cx?=	M1G5UmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD60O{DPxE1w	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd5OEe2Okc,OjV5N{i3OlY9N2F-
K562	NWjpOWtwTnWwY4Tpc44h[XO\|YYm=			M3KzfmlvcGmkaYTpc44hd2ZiQlPSMWFDVDFiYYX0c5Bpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDLOVYzKGOnbHzzMEBKSzVyIE2gNE41PzNizszNMi=>	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODhzN{WzPEc,OjB6MUe1N\|g9N2F-
insect cells	MWnGeY5kfGmxbjDhd5NigQ>?		NYLaXVVbOzBibXnudy=>	Ml3LTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCDQlyxJGUzPTWNIH31eIFvfCCneIDy[ZN{\WRiaX6gbY5{\WO2IHPlcIx{KGGodHXyJFMxKG2rboOgZpkhTlKHVDDhd5NigSxiSVO1NEA:KDBwNEi1PEDPxE1w	NH;CUXU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OwNVcxOyd-MkOzNFE4ODN:L3G+
Sf9	M1KzRWZ2dmO2aX;uJIF{e2G7			M2K0e2JqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gdoVud3SnIIPpeIUhd2ZiTj30[ZJucW6jbDDo[ZhicGm\|dHnkbY5mNXSjZ3fl[EBCSkx{IHX4dJJme3OnZDDpckBVemmlaH;wcJV{cWFibnmgbY5n\WO2ZXSgV4Y6KGOnbHzzJIJ6KGm\|b4To[ZJu[WxidHn0doF1cW:wIHPhcI9zcW2ndILpZ{Bie3OjeTygT4QhRSByLkWg{txONg>?	M4Htc\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEG3N\|Q{Lz5{MUSxO\|M1OzxxYU6=
primary leukemia cells	NEDCTmxEgXSxdH;4bYNqfHliYYPzZZk>		M1;jVVczKGi{cx?=	MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdolu[XK7IHzleYtmdWmjIHPlcIx{KGm\|b3zheIVlKG[{b32gZYN2fGVibYnlcI9q\CCuZYXr[Y1q[SCyYYTp[Y51KGW6cILld5NqdmdiRlzUN{1FQDN3WTDteZRifGmxbjDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB5MjDodpMh[nlibIXjbYZmemG\|ZTDhd5NigSxiSVO1NEA:KDBwNTFOwG0v	NWj5dmFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlEzODFpPkKyNlIyOjBzPD;hQi=>
BA/F3	MkTiSpVv[3Srb36gZZN{[Xl?		NXO0[IdJPzJiaILz	MUfJcohq[mm2aX;uJI9nKFSHTD3MR2shMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hd3JiQ1PLMVgh[XO\|YYmsJGdKPTBiPTCwMlUh\|ryPLh?=	NGjGdFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nke4PVU2Oyd-Mk[3PFk2PTN:L3G+
K562	M1;4XGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			MV3BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNuIFnDOVAhRSByLkWg{txONg>?	MlvlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN\|NUK0PFMoRjJ\|M{WyOFg{RC:jPh?=
K562	MYDDfZRwfG:6aXPpeJkh[XO\|YYm=		MWe3NkBpenN?	MWrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDjZYxk\WmwLVHNJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	M2XYZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|OUixOVMzLz5{M{m4NVU{OjxxYU6=
K562	NX;0cFlzS3m2b4TvfIlkcXS7IHHzd4F6		NH7wWJU4OiCqcoO=	NGDPPFVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFczKGi{czD1d4lv\yCFYXzj[YlvKEGPIHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvPSEQvF2u	MmqzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5NUe2NFMoRjJ3N{W3OlA{RC:jPh?=
K562	Ml;wR5l1d3SxeHnjbZR6KGG\|c3H5			NG\afmJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{NCCLQ{WwJF0hOC53IN88UU4>	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6OU[3OEc,OjdzOEm2O\|Q9N2F-
BA/F3	NEfSTW9EgXSxdH;4bYNqfHliYYPzZZk>		NYe2bI5tPzJiaILz	Mor4R5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgRmEwTjNiY3XscJMh\XiycnXzd4lv\yC5aXzkJJR6eGViQlPSMWFDVCCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ1PLMVgh[XO\|YYmsJGlEPTBiPTCwMlUh\|ryPLh?=	M1jWSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{CxO\|A{Lz5{M{OwNVcxOzxxYU6=
K562	M{fmdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		M1vZXlQ5KGi{cx?=	M3PMbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS{W2NkBk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR\|UxKD1iMD61JO69VS5?	MmfXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7M{KwO\|EoRjJ\|OUOyNFcyRC:jPh?=
Sf9	Mo\ESpVv[3Srb36gZZN{[Xl?			NHjGVJhVWF:WUlHOV3BQWlSHUkqgbY5pcWKrdHnvckBw\iCDVGDhd4Uh[WO2aY\peJkhcW5iQlPSVE1mgHC{ZYPzbY5oKFOoOTDj[YxteyxiSVO1NEA:KDBwNTFOwG0v	M{PhWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MUW1PFQyLz5zNUG1OVg1OTxxYU6=
K562	MVrDfZRwfG:6aXPpeJkh[XO\|YYm=		MYO3NkBpenN?	NFTUVXlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAxNjVzIN88UU4>	NIfacVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkixOFg6OCd-Mk[4NVQ5QTB:L3G+
K562	NFHnVotEgXSxdH;4bYNqfHliYYPzZZk>		MleyOFghcHK\|	MnrTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT\|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG\|c3H5MEBKSzVyIE2gNE42OyEQvF2u	NUHi[I5QRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[3NFc5PDZpPkK2O\|A4QDR4PD;hQi=>
K562	M2X4XmFvfGmycn;sbYZmemG2aY\lJIF{e2G7		MkfPOFghcHK\|	NXL1PWcxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLOVYzKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO\|YYmsJGlEPTBiPTCwMlU{KM7:TT6=	NITtcY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEWyOVg{QCd-Mki1NlU5Ozh:L3G+
BA/F3	MYHGeY5kfGmxbjDhd5NigQ>?		MmXmO\|IhcHK\|	NVvQW5FSUW6qaXLpeIlwdiCxZjDLbZQh\XixbjCxNUBl\WyndHnvckApPTV5IITvJFU2QCC{ZYPp[JVmeyliYX7kJGQ5OT[KIH31eIFvfCBqdX7rco94diCxcnnnbY4qKHS{YX7z[oVkfGWmIHnuJI1wfXOnIFLBM2Y{KGOnbHzzJIF{e2W\|c3XkJIF{KGmwaHnibZRqd25ib3[gZ4VtdCCpcn;3eIghcW6ldXLheIVlKG[xcjC3NkBpenNiYomgUXRUKGG\|c3H5MEBIUTVyIE2gNE42OzVizszNMi=>	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
BA/F3	M2XabGZ2dmO2aX;uJIF{e2G7		MoDQO\|IhcHK\|	NEOzZmRKdmirYnn0bY9vKG:oIGDES2ZT[WyyaHGgWlU3OURxREi0NnYhdXW2YX70JEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5ibX;1d4UhSkFxRkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCPVGOgZZN{[XluIFfJOVAhRSByLkW2O{DPxE1w	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJyNES0NUc,OzB{MES0OFE9N2F-
K562	M{X5dGN6fG:2b4jpZ4l1gSCjc4PhfS=>		NXPWfJRzPDhiaILz	M13L[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGs2PjJiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPThizszNMi=>	NX\rfVlPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyPVU{QDBpPkKxNlk2OzhyPD;hQi=>
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LAMA-84	MnLIS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MVLJcohq[mm2aX;uJI9nKGi3bXHuJGxCVUFvOESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFAvODd\|MESg{txONg>?	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
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LB2518-MEL	M{nvZ2dzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NYjIcJROUW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxOk43ODl2IN88UU4>	M33iO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
NCI-H510A	M4HE[Gdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			MULJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNUGwRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOTdwMkS0NkDPxE1w	M2P2UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-441-T	NHrXPIJIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MorCTY5pcWKrdHnvckBw\iCqdX3hckBVTS12NEGtWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOTdwMki4OkDPxE1w	NHHVd249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
HH	NUfrclRGT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NFrTfZVKdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCxO{4{QTl7IN88UU4>	MlHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
LC4-1	NUPkOmpiT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M{nkfGlvcGmkaYTpc44hd2ZiaIXtZY4hVEN2LUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFE5NjB4NUKg{txONg>?	M1LVNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
KARPAS-45	MmTuS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NX\1WFlPUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEG4MlE5PDhizszNMi=>	M4PvUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
LB1047-RCC	M1rnTGdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			M{\oPWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxKD1iMUiuOFQ2OiEQvF2u	NVL6PWxJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
NKM-1	MXPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NFniNWJKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAyQS5\|NUWyJO69VS5?	NY\qVHQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
SCLC-21H	NWXrfpNmT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			NEPCRYFKdmirYnn0bY9vKG:oIHj1cYFvKFOFTFOtNlFJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB{MD6xNlQ3KM7:TT6=	NYrRRmJQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
RS4-11	MYnHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			M1rES2lvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzOC5\|M{C4JO69VS5?	NWr3cYk4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
ALL-PO	M1HKXWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NYfY[o5bUW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJyLkixOFkh\|ryPLh?=	NFTXZpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6PDFxJ{7TRW5ITVJ:L3G+
GDM-1	NVv3WWRHT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			MoL3TY5pcWKrdHnvckBw\iCqdX3hckBITE1vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlIvPTl2NTFOwG0v	MmHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
DMS-79	MUPHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NHTlXoJKdmirYnn0bY9vKG:oIHj1cYFvKESPUz23PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjRwNEmzOEDPxE1w	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MPP-89	M17XfWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NWPrWlhyUW6qaXLpeIlwdiCxZjDoeY1idiCPUGCtPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDJ3Lk[4O\|Qh\|ryPLh?=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
NB10	MX;Hdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			Mo\nTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTBiPTCyOk41PyEQvF2u	NUniWlk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
LS-513	M{fBfWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NF:5TZpKdmirYnn0bY9vKG:oIHj1cYFvKEyVLUWxN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOjZwOEi0O{DPxE1w	MkDQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
L-540	M1TLbWdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NH\FWHZKdmirYnn0bY9vKG:oIHj1cYFvKExvNUSwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUAzPi57MUSzJO69VS5?	NW[0SW9iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
ES1	Mn3WS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NGjsOWRKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gNlcvPTJzIN88UU4>	MlWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
NTERA-S-cl-D1	NFno[m9Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=			MUfJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOwMlUxQTNizszNMi=>	NVjMSpBpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
EW-1	MnnqS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			MWPJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IEOyMlk1PTRizszNMi=>	MmnlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
Calu-6	MoLrS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NHv1OnZKdmirYnn0bY9vKG:oIHj1cYFvKEOjbIWtOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hOzNwMUi1OUDPxE1w	MoXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
CTV-1	Mm\uS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			Ml25TY5pcWKrdHnvckBw\iCqdX3hckBEXFZvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|MvQTd6OTFOwG0v	M2Tyb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
YT	NInROHBIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NVewZpZxUW6qaXLpeIlwdiCxZjDoeY1idiC\VDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gN\|gvPTJyOTFOwG0v	M4jBdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
TE-6	MUTHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			NYi1NWxLUW6qaXLpeIlwdiCxZjDoeY1idiCWRT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1OS5{N{m3JO69VS5?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
HT-144	Ml3OS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NV7md\|B6UW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDRzLkW0PFYh\|ryPLh?=	NXLWW\|BXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQTRzLze+V2FPT0WUPD;hQi=>
EW-13	M4jnTmdzd3e2aDDJcohq[mm2aX;uJIF{e2G7			NWD0Ulc6UW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDJwMke5NUDPxE1w	Ml\GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
KALS-1	MlLMS5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NEO2[\|FKdmirYnn0bY9vKG:oIHj1cYFvKEuDTGOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDNwMUOyPEDPxE1w	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
MOLT-16	MWHHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MWjJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvMU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2NjB5NUKg{txONg>?	MlnWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
D-336MG	NHLSVXZIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NEPaUGZKdmirYnn0bY9vKG:oIHj1cYFvKERvM{O2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR3Lkm1PVkh\|ryPLh?=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5OFEwLz6VQV7HSXI9N2F-
TE-11	MXrHdo94fGhiSX7obYJqfGmxbjDhd5NigQ>?			MofsTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyIE2gOFYvPjV\|IN88UU4>	M2W2VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EB2	Mmn4S5Jwf3SqIFnubIljcXSrb36gZZN{[Xl?			NUPSdWFRUW6qaXLpeIlwdiCxZjDoeY1idiCHQkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ3NjZ7OTFOwG0v	MojmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVQyNyd-U1HOS2VTRC:jPh?=
SK-N-DZ	NUXOc2ZVT3Kxd4ToJGlvcGmkaYTpc44h[XO\|YYm=			M3[xZWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTj3EXkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDhwMEm2NUDPxE1w	M3XLR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
SW684	NHP4ZppIem:5dHigTY5pcWKrdHnvckBie3OjeR?=			M{OxVmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d4OESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ5NjJ4OUWg{txONg>?	M{XSXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=
EW-18	NHTtN41Iem:5dHigTY5pcWKrdHnvckBie3OjeR?=			NIrxUWlKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUG4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1QC52M{m1JO69VS5?	M2S3V\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk1OS9pPmPBUmdGWjxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-STAT3 / STAT3 / p-STAT5 / STAT5; PubMed: 18981115 J Immunol For phospho-STAT3 and Phospho-STAT5 detection, cells were then activated for 6 hrs with anti-CD3 and anti-CD28 Ab. Equivalent amounts of protein from cell lysates were separated by SDS-PAGE and western blot analysis was then performed using anti-phospho S䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖 p-ZAP70 / ZAP70 / p-LAT / LAT; PubMed: 18981115 J Immunol For the analysis of imatinib interference with early TCR signaling events, cells were activated for 5 min with anti-CD3 and anti-CD28 Abs and blots were probed with anti-phospho ZAP70, anti-ZAP70, anti-phospho LAT or anti-LAT antibodies. Untreated, non-ac䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 	18981115
Immunofluorescence	RelB; PubMed: 20371728 Mol Cancer Ther Nuclear proteins were extracted from the untreated and treated cells and nuclear levels of RelA and RelB were confirmed by immunocytochemistry Cortactin / F-actin; PubMed: 20937825 J Biol Chem NIH3T3-SrcY527F cells were treated with DMSO or with 10 μm STI571 for 16 h, fixed and co-stained for cortactin (red, left panels) and F-actin (green, middle panels). Merged fields (right panels) demonstrate co-localization between cortactin and F-actin at䲧疝Ỵ疞㧀疜	20371728 20937825
Growth inhibition assay	Cell viability ; PubMed: 28435223 Drug Des Devel Ther (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. 䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ뾠Ղ䐺	28435223

In vivo

Imatinib produces a different antitumor effect on three xenografted tumors derived from surgical samples of fresh human small cell lung cancers, with 80%, 40% and 78% growth inhibition of SCLC6, SCLC61 and SCLC108 tumors, respectively, and no significant inhibition of SCLC74 growth. ^[5] In high fat fed ApoE(-/-) mice, Imatinib significantly reduces the high fat-induced lipid staining area by 30%, 27% and 35% compared to high-fat diet untreated controls when dosed by gavage at 10, 20 and 40 mg/kg, respectively, and suppresses carotid artery lipid accumulation. ^[6]

Protocol

Kinase Assay:^[1]	- Collapse PDGF receptor kinase activity: PDGF receptor is immunoprecipitated from BALB/c 3T3 cell extracts with rabbit antiserum to the murine PDGF receptor for 2 hours on ice. Protein A-Sepharose beads are used to collect the antigen-antibody complexes. The immunoprecipitates are washed twice with TNET (50 mM Tris, pH 7.5, 140 mM NaCl, 5 mM EDTA, 1% Triton X-100), once with TNE (50 mM Tris, pH 7.5, 140 mM EDTA), and once with kinase buffer (20 mM Tris, pH 7.5,10 mM MgCl₂). After stimulation with PDGF (50 ng/mL) for 10 minutes at 4 °C, different concentrations of drug are added to the reaction mixture. PDGF receptor kinase activity is determined by incubation with 10 μCi [7-³³P]-ATP and l μM ATP for 10 minutes at 4 °C. Immune complexes are separated by SDS-PAGE on 7.5% gels.
Cell Research:^[3]	- Collapse Cell lines: BON-1 cells and NCI-H727 cells Concentrations: ~100 μM Incubation Time: 48 hours Method: BON-1 cells and NCI-H727 cells are seeded into flat-bottomed 96-well plates in triplicate and allowed to adhere overnight in 10% fetal bovine serum-supplemented DMEM or RPMI 1640 complete medium, respectively; the medium is then exchanged for serum-free medium (negative control) or serum-free medium containing serial dilutions of Imatinib. After 48 hours (control cultures do not reach confluence), the number of metabolically active cells is determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and absorbance is measured in a Packard Spectra microplate reader at 540 nm. Growth inhibition is calculated using the following formula: inhibition rate = (1 − a / b) × 100%, where a and b are the absorbance values of the treated and control groups, respectively. (Only for Reference)
Animal Research:^[5]	- Collapse Animal Models: SCLC6, SCLC61, SCLC 74 and SCLC108 small cell lung cancers are injected into Swiss mice (nu/nu, female). Dosages: 70 or 100 mg/kg Administration: Administered via i.p. (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	118 mg/mL (200.09 mM)
	Water	118 mg/mL (200.09 mM)
	Ethanol	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Imatinib (STI571) Mesylate SDF

Molecular Weight	589.71
Formula	C₂₉H₃₁N₇O.CH₄SO₃
CAS No.	220127-57-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	Gleevec, Glivec, CGP-57148B
Smiles	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

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Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Note：1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02687425	Unknown status	Drug: Pioglitazone\|Drug: imatinib mesylate	Leukemia Myelogenous Chronic BCR-ABL Positive	Meng Li\|Tongji Hospital	February 2016	Phase 2
NCT02303899	Completed	Drug: Gemcitabine\|Drug: Imatinib mesylate	Mesothelioma Malignant	Istituto Clinico Humanitas	November 2014	Phase 2
NCT01898377	Terminated	Drug: Imatinib mesylate Mycophenolate mofetil	Chronic Graft-versus-host Disease	Seoul National University Hospital	August 2013	Phase 2
NCT02891395	Completed	Drug: Imatinib Mesylate and Nilotinib	Graft Versus Host Disease	University Hospital Lille\|Novartis	December 24 2012	Phase 2

Tech Support

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Bcr-Abl Signaling Pathway Map

Bcr-Abl Inhibitors with Unique Features

Selective Bcr-Abl Inhibitor

Nilotinib (AMN-107) : Bcr-Abl-selective, IC50<30 nM.
Most Potent Bcr-Abl Inhibitor

GZD824 : Bcr-Abl(WT), IC50=0.34 nM; Bcr-Abl(T315I), IC50=0.68 nM.
FDA-approved Bcr-Abl Inhibitor

Dasatinib : Approved by FDA for CML and Ph+ ALL.
Newest Bcr-Abl Inhibitor

GZD824 : Orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

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Imatinib (STI571) Mesylate