Dexamethasone (DHAP)

Catalog No.S1322

Dexamethasone (DHAP) Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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In DMSO USD 130 In stock
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  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

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Biological Activity

Description Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells NVHsXmVJTnWwY4Tpc44h[XO|YYm= M1iw[WFkfGm4aYT5JIF1KGi3bXHuJIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXjFiY3XscJMh[XO|ZYPz[YQh[XNicnXwdoV{e2mxbjDv[kBVVkZiYX7kJGlNNTFvYnX0ZU1qdmS3Y3XkJGUue2WuZXP0bY4h\2WwZTDlfJBz\XO|aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWQ2OD1yLkGgcm0> NF\md3oyQDB|Mk[xNC=>
HEK293 cells Mmq2SpVv[3Srb36gZZN{[Xl? NETxNIRFcXOybHHj[Y1mdnRib3[gX|NJZS2jbHTvd5Rmem:wZTDmdo9uKGi3bXHuJI1qdmW{YXzvZ49zfGmlb3nkJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOsJGtqRTBwM{[gcm0> NXLjNpVIOjR2NE[3Nlg>
human PBMC MXPGeY5kfGmxbjDhd5NigQ>? MmHwRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDQRm1EKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[W62aT3DSFMucW6mdXPl[EBIVS2FU1[gdJJw\HWldHnvckBi\nSncjC0PEBpenNuIFXDOVA:OC52NzDuUS=> MUeyN|E6QTR6NR?=
HFF cells M4DIcWZ2dmO2aX;uJIF{e2G7 NWfGPGljSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNOSC|dHnteYxifGWmIFnMOkBxem:mdXP0bY9vKGmwIFjGSkBk\WyuczDifUB1emGwc4LldJJme3Orb36gZZN{[XluIFXDOVA:OC53IH7N NVrSOIxNOTd4OUK1NVk>
human A549 cells MnPtSpVv[3Srb36gZZN{[Xl? MkHTRYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gRVU1QSClZXzsd{Bie3Onc4Pl[EBieyCnZn\lZ5Qhd25iR2LFJJBzd22xdHXyJJJme3CxboPlJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiYYPzZZktKEWFNUC9NUBvVQ>? M4DRRVE3PjR|ME[w
NHDFneo cells MVXGeY5kfGmxbjDhd5NigQ>? M2LqXGFkfGm4aYT5JIF1KGi3bXHuJGdTKGW6cILld5Nm\CCrbjDOTGRHdmWxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhUUxvNjDwdo9lfWO2aX;uMEBKSzVyPUGuOEBvVQ>? NGX0NpAyPzdyNUO2Ni=>
human HeLa cells NVXMTlVFTnWwY4Tpc44h[XO|YYm= MV;UdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgZ49tdGGpZX7hd4UheHKxbX;0[ZIh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUGuOVghdk1? M4rnbFIxPzJ5N{Sz
human SW1353 cells NUnkcFhFTnWwY4Tpc44h[XO|YYm= MWLUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iU2exN|U{KGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gTWwuOS2rbnT1Z4VlKE2PUD2xN{Bxem:mdXP0bY9vKGGodHXyJFI1KGi{czDifUBGVEmVQTygTWM2OD1zLkigcm0> Mn\xNlU4ODZzMEC=
rat polymorphonuclear leukocytes NEO2TGtHfW6ldHnvckBie3OjeR?= MX[yNEBucW6| NUfabFh[SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiC{YYSgdI9tgW2xcoDoc452[2ynYYKgcIV2c2:leYTld{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2|dHnteYxifGWmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFIxKG2rboOgZpkhT3KrZYPzJI1mfGixZDygTWM2OD1{LkOgcm0> M4HnVlIzPTB4NkKw
human THP1 cells MXLGeY5kfGmxbjDhd5NigQ>? Mli4WJJidnO{ZYDy[ZN{cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{LX3l[IlifGWmIHHueIlqdm[uYX3tZZRwenliYXP0bZZqfHliaX6gbJVu[W5iVFjQNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGlNNThicILv[JVkfGmxbjygTWM2OD1{LkWxJI5O MXOyNFczPzd2Mx?=
human NP1 cells MkDpSpVv[3Srb36gZZN{[Xl? MkHSRYdwdmm|dDDhZ5Rqfmm2eTDheEBIWiCuaXfhcoQh[mmwZHnu[{Bld22jaX6g[ZhxemW|c3XkJIlvKGi3bXHuJG5ROSClZXzsd{Bie3Onc4Pl[EBieyCpbIXjc4NwenSrY3;p[EBz\XOyb37z[UBmdGWvZX70JJRz[W6|YXP0bZZifGmxbjDifUBISUx2IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME20MlIhdk1? MnnaNVk{OjF|NEG=
human HeLa cells MULGeY5kfGmxbjDhd5NigQ>? NFTXeo1VemGwc3HjeIl3[XSrb36gc4YhT1JvTFLEJIV5eHKnc4Pl[EBqdiCqdX3hckBJ\UyjIHPlcIx{KGOxLXX4dJJme3OrbnegS2FNPC2GQlSgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTRwMjDuUS=> NHXBeGUzPDBzMU[0OC=>
human 13D3/Huh7 cells NHzwboxHfW6ldHnvckBie3OjeR?= MWqyOEBp M1jseHRz[W6|YXP0bZZifGmxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjCxN2Q{N0i3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKHS7cn;zbY5mKGGvaX7veJJidnOoZYLhd4Uh[WO2aY\peJkh[W[2ZYKgNlQhcHK|LDDFR|UxRTVibl2= Mlz4NlExPzNzOUC=
rat R1 cells NFjDS2NHfW6ldHnvckBie3OjeR?= MXmxNEDPxE1? NXLwNpd6OjRiaB?= NX;ROHZ[UW6qaXLpeIlwdiCxZjDncJVkd2OxcoTpZ49q\CC{ZXPldJRwei2pbIXjc4NwenSrY3;p[EBkd22ybHX4JJRz[W6|ZnXjeIVlKGmwIILheEBTOSClZXzsd{Bie3Onc4Pl[EBieyCmb4fuMZJm\3WuYYTpc44hd2ZiVGDBMZJme3CxboPpeoUh\WynbXXueEBxem:rbn\sZY1u[XSxcomg[4Vv\SCneIDy[ZN{cW:wIHH0JFExKHWPIHHmeIVzKDJ2IHjyd{BjgSCkZYThMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9OUBvVQ>? MojtNVg1OTJ|OUe=
human RPMI8226 cells M3vacHBzd2yrZnXyZZRqd25iYYPzZZk> NV7ZVlh5PCCmYYnz NU\SUHJ{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDSVG1KQDJ{NjDj[YxteyCjZoTldkA1KGSjeYOsJGlEPTB;Nj61JI5O NGTkXVcyPzdyNUO2Ni=>
african green monkey COS7 cells M1W2XWZ2dmO2aX;uJIF{e2G7 M1O1[2Fod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1NSkRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVcvOiCwTR?= M3fKe|E6QDZ|MEiz
human PBMC MUfGeY5kfGmxbjDhd5NigQ>? M{fDc|I1KGh? NUn2[|JWSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBRSk2FIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiUFjBMYlv\HWlZXSgTWZP\2GvbXGgdJJw\HWldHnvckBi\nSncjCyOEBpenN? M3nPTFI{OTl7NEi1
human H13 cells NYX6eXd7TnWwY4Tpc44h[XO|YYm= M3nobmlvcGmkaYTpc44hd2ZiZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUDF|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\2y3Y3;jc5J1cWOxaXStbY5lfWOnZDDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiMzDodpMh[nliW{PIYU11cHmvaXTpcoUhcW6lb4Lwc5JifGmxbjDhd5NigSxiRVO1NF06Njdibl2= MY[yN|E6QTR6NR?=
mouse RAW264.7 cells NF\tdXhHfW6ldHnvckBie3OjeR?= NF\tOZEyQCCq NGXxVJFCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5HNWGucHjhJJNm[3KndHnvckBi\nSncjCxPEBpenNuIFnDOVA:OC5yMTFOwG0> NWT5fWt1OjF|NUO1OFM>
293 MSR cells NVn4bYQyTnWwY4Tpc44h[XO|YYm= NGX0e3I3OCCvaX7z MmHKSIl{eGyjY3Xt[Y51KG:oIGuzTH0u\GW6YX3leIhie2:wZTDoeY1idiCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBidHCqYTDlfJBz\XO|ZXSgbY4hOjl|IF3TVkBk\WyuczDh[pRmeiB4MDDtbY5{KGK7IIPjbY51cWyuYYTpc44h[2:3boTpcoctKEWFNUC9NVIvPSCwTR?= MYGyN|E6QTR6NR?=
Sf9 cells MYTGeY5kfGmxbjDhd5NigQ>? M2rTRmJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gdoVkd22kaX7hcpQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIGPmPUBk\Wyucx?= NELROWozODd{N{e0Ny=>
RAW 264.7 cells M3fVSGZ2dmO2aX;uJIF{e2G7 MXGyOEBp NGHRRlBKdmirYnn0bY9vKG:oIHnueIVz\mW{b36g[4FudWFvc4TpcZVt[XSnZDDOU{Bxem:mdXP0bY9vKGmwIGLBW{AzPjRwNzDj[YxteyCjZoTldkAzPCCqcoOsJGlEPTB;MD6wNkDPxE1? M{HvXVE4OzZ5MUK0
mouse J774A.1 cells MojGSpVv[3Srb36gZZN{[Xl? MoLYTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDUUmZidHCqYTDwdo9lfWO2aX;uJIlvKG2xdYPlJGo4PzSDLkGgZ4VtdHNuIFnDOVA:PDhibl2= MUexO|g6Ojl2MR?=
human HepG2 cells M1zTVWZ2dmO2aX;uJIF{e2G7 MVuyOEBp MVTBZ5RqfmG2aX;uJI9nKHKjdDDQXHIh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[mG|ZXSgcJVucW6nc3PlcpQh[W6jbInzbZMtKEWFNUC9Nk43KM7:TR?= NUf4fmx5OjB7Nk[wOFM>
human U2OS cells MnPBSpVv[3Srb36gZZN{[Xl? NF7IfpgyQCCq MUXB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{LVzCSEBqdiCqdX3hckBWOk:VIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghT2GuND3ERmQh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[geJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7IHHmeIVzKDF6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MUWuPFQ5QSEQvF2= NH61Z4MzODhzMk[4NS=>
mouse thymocytes MWHGeY5kfGmxbjDhd5NigQ>? NFKzb4EyKM7:TR?= MXiyOEBp MoPDTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDtc5V{\SC2aIntc4N6fGW|IHHzd4V{e2WmIHHzJIlvfGW{boXjcIVwe2:vYXygSG5CKG[{YXft[Y51[XSrb36gZZQhOSC3TTDh[pRmeiB{NDDodpMh[nliYXfhdo9{\SCpZXyg[Yxm[3S{b4Doc5Jme2m| M4\VVFI1Pzl2N{S4
human HMC1 cells MkXxSpVv[3Srb36gZZN{[Xl? MmrzNUBp Mm\IcY12dm:vb3T1cIF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFjNR|Eh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDwbI9z[m:uIEGyMY16emm|dHH0[UAyOy2jY3X0ZZRmN0F{M{G4O{1{fGmvdXzheIVlKEmOMT3i[ZRiKHOnY4LleIlwdiC2cnXheIVlKDFiaIKgdJJqd3JidH:gN|AhdWmwczDwbI9z[m:uIEGyMY16emm|dHH0[UAyOy2jY3X0ZZRmN0F{M{G4O{BkcGGubHXu[4Uh[nliV3XzeIVzdiCkbH;0eIlv\yCjbnHsfZNqew>? MV:yNVMxOjl4Nx?=
human monocytes NVLFU2pqTnWwY4Tpc44h[XO|YYm= Mn\oOUDPxE1? NHf0THQzOCCq MVzBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIH3vco9kgXSnczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGNQYDJiZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJyIHjyd{B2e2mwZzDyZYJjcXRicH;sfYNtd26jbDDhcpRq[m:meTDJ[2ch[nliU1TTMXBCT0ViYX7hcJl{cXN? MY[yNVg1Ozl|NR?=
COS7 cells MlTrSpVv[3Srb36gZZN{[Xl? MVuxJO69VQ>? MUjB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IGG1O|BCKG23dHHueEBqdiCFT2O3JINmdGy|IHH0JFEhfU1iYomgUmYuc2GycHHCMYx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NX3Uc3EyOThyM{i5O|A>
human MDA-kb2 cells NXqwbHN7TnWwY4Tpc44h[XO|YYm= MnfpRYdwdmm|dDDhZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBqdiCqdX3hckBOTEFva3KyJINmdGy|IHHzd4V{e2WmIHHzJJN1cW23bHH0bY9vKG:oIHz1Z4ln\XKjc3WgZYN1cX[rdImgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 MX6xPVU6OjJ2NR?=
human HeLaS3 cells MV3GeY5kfGmxbjDhd5NigQ>? NUmzN2h{OiCq M1LjZmRqe3CuYXPlcYVvfCCxZjDbN2heTGW6YX3leIhie2:wZTDmdo9uKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGhmVGGVMzDj[YxteyCjZoTldkAzKGi{cx?= NX\zc4xiOjN2MEOwPFI>

... Click to View More Cell Line Experimental Data

In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03472573 Recruiting Recurrent B Acute Lymphoblastic Leukemia|Refractory B Acute Lymphoblastic Leukemia Sidney Kimmel Cancer Center at Thomas Jefferson University|Pfizer|Thomas Jefferson University May 9 2018 Phase 1
NCT03367572 Recruiting Breast Carcinoma Gary Morrow|National Cancer Institute (NCI)|University of Rochester March 9 2018 Phase 3
NCT03374514 Recruiting Sensorineural Hearing Loss|Cochlear Implant Hospital Italiano de Buenos Aires August 9 2017 Phase 3
NCT03136146 Recruiting Hematopoietic/Lymphoid Cancer|Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma|Burkitt Leukemia/Lymphoma M.D. Anderson Cancer Center August 9 2017 Phase 2
NCT02477215 Active not recruiting Multiple Myeloma Parameswaran Hari|Medical College of Wisconsin October 9 2015 Phase 1|Phase 2
NCT02412878 Active not recruiting Multiple Myeloma Amgen September 9 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID