Dexamethasone

For research use only.

Catalog No.S1322

25 publications

Dexamethasone  Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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10mM (1mL in DMSO) USD 130 In stock
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Selleck's Dexamethasone has been cited by 25 publications

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Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells MXHGeY5kfGmxbjDhd5NigQ>? MX;BZ5Rqfmm2eTDheEBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR3YyKGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gWG5HKGGwZDDJUE0yNWKndHGtbY5lfWOnZDDFMZNmdGWldHnuJIdmdmViZYjwdoV{e2mxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXEOVA:OC5zIH7N NEXHeFgyQDB|Mk[xNC=>
HEK293 cells MX;GeY5kfGmxbjDhd5NigQ>? MXXEbZNxdGGlZX3lcpQhd2ZiW{PIYU1idGSxc4Tldo9v\SCocn;tJIh2dWGwIH3pcoVz[WyxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpQVAvOzZibl2= M2fMRlI1PDR4N{K4
human PBMC M{Hre2Z2dmO2aX;uJIF{e2G7 M{W2eWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gVGJOSyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGGwdHmtR2Q{NWmwZIXj[YQhT01vQ2PGJJBzd2S3Y4Tpc44h[W[2ZYKgOFghcHK|LDDFR|UxRTBwNEegcm0> NH3DOGwzOzF7OUS4OS=>
HFF cells MkXmSpVv[3Srb36gZZN{[Xl? MmDlRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFnMNUB{fGmvdXzheIVlKEmONjDwdo9lfWO2aX;uJIlvKEiIRjDj[YxteyCkeTD0doFve3KncILld5Nqd25iYYPzZZktKEWFNUC9NE42KG6P MVWxO|Y6OjVzOR?=
human A549 cells MkjXSpVv[3Srb36gZZN{[Xl? M1eycGFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIFfSSUBxem:vb4TldkBz\XOyb37z[UBjgSCudXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCHQ{WwQVEhdk1? NVT4OGZrOTZ4NEOwOlA>
NHDFneo cells MmfGSpVv[3Srb36gZZN{[Xl? NUO1d5lySWO2aY\peJkh[XRiaIXtZY4hT1JiZYjwdoV{e2WmIHnuJG5JTE[wZX:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCLTD22JJBzd2S3Y4Tpc44tKEmFNUC9NU41KG6P NHy2SlUyPzdyNUO2Ni=>
human HeLa cells NXfoR3VUTnWwY4Tpc44h[XO|YYm= MVrUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgZ49tdGGpZX7hd4UheHKxbX;0[ZIh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUGuOVghdk1? NEnXOoMzODd{N{e0Ny=>
human SW1353 cells MnvsSpVv[3Srb36gZZN{[Xl? NGLuS4ZVemGwc4LldJJme3Orb36gZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gV3cyOzV|IHPlcIx{KGG|c3Xzd4VlKGG|IILldJJme3Orb36gc4YhUUxvMT3pcoR2[2WmIF3NVE0yOyCycn;keYN1cW:wIHHmeIVzKDJ2IHjyd{BjgSCHTFnTRUwhUUN3ME2xMlghdk1? Mm\DNlU4ODZzMEC=
rat polymorphonuclear leukocytes MVzGeY5kfGmxbjDhd5NigQ>? MXiyNEBucW6| NIfrTXFCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKHKjdDDwc4x6dW:{cHjvcpVkdGWjcjDs[ZVsd2O7dHXzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNXO2aX31cIF1\WRibnn0dolkKG:6aXTlJJBzd2S3Y4Tpc44h[W[2ZYKgNlAhdWmwczDifUBIemmnc4OgcYV1cG:mLDDJR|UxRTJwMzDuUS=> NGHvbpgzOjVyNk[yNC=>
human THP1 cells Mni2SpVv[3Srb36gZZN{[Xl? MX\UdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCWSGCxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgTWwuQCCycn;keYN1cW:wLDDJR|UxRTJwNUGgcm0> NWixUGNVOjB5Mke3OFM>
human NP1 cells NUXhV5lbTnWwY4Tpc44h[XO|YYm= MkPTRYdwdmm|dDDhZ5Rqfmm2eTDheEBIWiCuaXfhcoQh[mmwZHnu[{Bld22jaX6g[ZhxemW|c3XkJIlvKGi3bXHuJG5ROSClZXzsd{Bie3Onc4Pl[EBieyCpbIXjc4NwenSrY3;p[EBz\XOyb37z[UBmdGWvZX70JJRz[W6|YXP0bZZifGmxbjDifUBISUx2IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME20MlIhdk1? NHrte5EyQTN{MUO0NS=>
human HeLa cells MXzGeY5kfGmxbjDhd5NigQ>? NUjIXnViXHKjboPhZ5RqfmG2aX;uJI9nKEeULVzCSEBmgHC{ZYPz[YQhcW5iaIXtZY4hUGWOYTDj[YxteyClbz3lfJBz\XO|aX7nJGdCVDRvRFLEJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD12LkKgcm0> NXzYdWNoOjRyMUG2OFQ>
human 13D3/Huh7 cells NIrSclFHfW6ldHnvckBie3OjeR?= MoqyNlQhcA>? NGDRTmFVemGwc3HjeIl3[XSrb36gZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gNVNFOy:KdXi3JINmdGy|IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iC2eYLvd4lv\SCjbXnuc5Rz[W6|ZnXyZZNmKGGldHn2bZR6KGGodHXyJFI1KGi{czygSWM2OD13IH7N M3G5WVIyODd|MUmw
rat R1 cells NFKyPZhHfW6ldHnvckBie3OjeR?= M4XiS|ExKM7:TR?= MWSyOEBp Mon0TY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1odHWlb3PvdpRq[2:rZDDjc41xdGW6IITyZY5{\mWldHXkJIlvKHKjdDDSNUBk\WyuczDhd5Nme3OnZDDhd{Bld3ewLYLl[5Vt[XSrb36gc4YhXFCDLYLld5BwdnOrdnWg[YxmdWWwdDDwdo9qdm[uYX3tZZRwenliZ3Xu[UBmgHC{ZYPzbY9vKGG2IEGwJJVOKGGodHXyJFI1KGi{czDifUBj\XSjLXfhcIFkfG:|aXThd4Uh[XO|YYmsJGlEPTB;NTDuUS=> NWrvOYFxOTh2MUKzPVc>
human RPMI8226 cells MY\Qdo9tcW[ncnH0bY9vKGG|c3H5 M2LhPVQh\GG7cx?= MnW4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCUUF3JPFIzPiClZXzsd{Bi\nSncjC0JIRigXNuIFnDOVA:Pi53IH7N MknkNVc4ODV|NkK=
african green monkey COS7 cells M2Czb2Z2dmO2aX;uJIF{e2G7 M2PjcWFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1NSkRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVcvOiCwTR?= NWLzZpVZOTl6NkOwPFM>
human PBMC NWLwO4hUTnWwY4Tpc44h[XO|YYm= NYTseXBuOjRiaB?= NIjFVlNCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJHBDVUNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCSSFGtbY5lfWOnZDDJSm5o[W2vYTDwdo9lfWO2aX;uJIFnfGW{IEK0JIhzew>? NX;KR5dVOjNzOUm0PFU>
human H13 cells MmLVSpVv[3Srb36gZZN{[Xl? Ml7yTY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBJOTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBodHWlb3PvdpRq[2:rZD3pcoR2[2WmIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB|IHjyd{BjgSCdM1jdMZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHHzd4F6NCCHQ{WwQVkvPyCwTR?= NFjPTmQzOzF7OUS4OS=>
mouse RAW264.7 cells NX3lTZVXTnWwY4Tpc44h[XO|YYm= NEjtZ4EyQCCq NEntTZZCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5HNWGucHjhJJNm[3KndHnvckBi\nSncjCxPEBpenNuIFnDOVA:OC5yMTFOwG0> MoLLNlE{PTN3NEO=
293 MSR cells NGTmc3ZHfW6ldHnvckBie3OjeR?= MVe2NEBucW6| MU\EbZNxdGGlZX3lcpQhd2ZiW{PIYU1l\XijbXX0bIF{d26nIHj1cYFvKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIFteGijIHX4dJJme3OnZDDpckAzQTNiTWPSJINmdGy|IHHmeIVzKDZyIH3pcpMh[nlic3PpcpRqdGyjdHnvckBkd3WwdHnu[{whTUN3ME2xNk42KG6P NYKyfFFzOjNzOUm0PFU>
Sf9 cells MUXGeY5kfGmxbjDhd5NigQ>? MUjCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlZ49u[mmwYX70JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgZ4VtdHN? NUjseG9HOjB5Mke3OFM>
RAW 264.7 cells M2LCZWZ2dmO2aX;uJIF{e2G7 NGHjVZMzPCCq MYTJcohq[mm2aX;uJI9nKGmwdHXy[oVzd25iZ3HtcYEue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJIlvKFKDVzCyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OC5yMjFOwG0> MkLGNVc{PjdzMkS=
mouse J774A.1 cells NYjuVIJ1TnWwY4Tpc44h[XO|YYm= NEHUeI9KdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44hcW5ibX;1d4UhUjd5NFGuNUBk\WyuczygTWM2OD12ODDuUS=> Mm\UNVc5QTJ7NEG=
human HepG2 cells MorpSpVv[3Srb36gZZN{[Xl? NHTtdJIzPCCq NUHWbFYySWO2aY\heIlwdiCxZjDyZZQhWFiUIHX4dJJme3OnZDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHLhd4VlKGy3bXnu[ZNk\W62IHHuZYx6e2m|LDDFR|UxRTJwNjFOwG0> MlLPNlA6PjZyNEO=
human U2OS cells MUXGeY5kfGmxbjDhd5NigQ>? NXX6bm51OThiaB?= NU\PdG1NSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1NSkRiaX6gbJVu[W5iVULPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFfhcFQuTEKGIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHS{YX7zZYN1cX[jdHnvckBi[3Srdnn0fUBi\nSncjCxPEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE2Njh2OEmg{txO MmKwNlA5OTJ4OEG=
mouse thymocytes Ml2wSpVv[3Srb36gZZN{[Xl? M37jflEh|ryP NFribIszPCCq NFzNeFlKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJI1wfXOnIITofY1w[3m2ZYOgZZN{\XO|ZXSgZZMhcW62ZYLueYNt\W:|b33hcEBFVkFiZoLh[41mdnSjdHnvckBifCBzIIXNJIFnfGW{IEK0JIhzeyCkeTDh[4Fzd3OnIHflcEBmdGWldILvdIhwemW|aYO= Mm\oNlQ4QTR5NEi=
human HMC1 cells NVK5d3FkTnWwY4Tpc44h[XO|YYm= M13xblEhcA>? MnzVcY12dm:vb3T1cIF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFjNR|Eh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDwbI9z[m:uIEGyMY16emm|dHH0[UAyOy2jY3X0ZZRmN0F{M{G4O{1{fGmvdXzheIVlKEmOMT3i[ZRiKHOnY4LleIlwdiC2cnXheIVlKDFiaIKgdJJqd3JidH:gN|AhdWmwczDwbI9z[m:uIEGyMY16emm|dHH0[UAyOy2jY3X0ZZRmN0F{M{G4O{BkcGGubHXu[4Uh[nliV3XzeIVzdiCkbH;0eIlv\yCjbnHsfZNqew>? MkfwNlE{ODJ7Nke=
human monocytes MmTDSpVv[3Srb36gZZN{[Xl? NVK4RVNSPSEQvF2= NXK0SmNLOjBiaB?= NEHIc3VCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJI1wdm:leYTld{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEORWEKg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEKwJIhzeyC3c3nu[{Bz[WKkaYSgdI9tgWOub37hcEBidnSrYn;kfUBK\0diYomgV2RUNVCDR1WgZY5idHm|aYO= MnH5NlE5PDN7M{W=
COS7 cells M{PRfWZ2dmO2aX;uJIF{e2G7 MVixJO69VQ>? NHKwcohC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJHE2PzCDIH31eIFvfCCrbjDDU3M4KGOnbHzzJIF1KDFidV2gZpkhVkZva3HwdIFDNWy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= NYLjN2U{OThyM{i5O|A>
human MDA-kb2 cells M{W1eGZ2dmO2aX;uJIF{e2G7 NWG4R3VJSWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtb4IzKGOnbHzzJIF{e2W|c3XkJIF{KHO2aX31cIF1cW:wIH;mJIx2[2moZYLhd4Uh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 MXKxPVU6OjJ2NR?=
human HeLaS3 cells NFHGR|hHfW6ldHnvckBie3OjeR?= NYHWTHk3OiCq NUDyXZI5TGm|cHzhZ4Vu\W62IH;mJHs{UF2GZYjhcYV1cGG|b37lJIZzd21iZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUGWOYWOzJINmdGy|IHHmeIVzKDJiaILz Mkn1NlM1ODNyOEK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bcl-xl / Mcl-1 / Survivin / IAP1 ; 

PubMed: 28696369     


Bcl-xl, Bcl-2, Survivin, Mcl-1, and IAP1 protein levels were determined via Western blot analysis.

Cyclin D1 / Cyclin E / COX-2 / MMP-9 ; 

PubMed: 28696369     


Cyclin D1, Cyclin E, COX-2, and MMP-9 protein levels were determined via Western blot analysis.

Bax / p21; 

PubMed: 28696369     


The protein levels of Bax and p21 were determined via Western blot analysis.

p-JNK / JNK / p-p38 / p38 / p-ERK / ERK ; 

PubMed: 28696369     


The cells were treated with 100 μM of DHAP for the time periods stated; whole-cell extracts were then prepared and analyzed via Western blot analysis for p-p38 (Thr180/Tyr182), p-JNK (Thr183/Tyr185), and p-ERK1/2 (Thr202/Tyr204) by Western blot analysis. To confirm equal protein loading, the immunoblot was stripped and reprobed for JNK, p38, and ERK1/2. The results shown are representative of the three independent experiments

28696369
In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04345588 Not yet recruiting Drug: Dexamethasone injection Dexamethasone Efficacy as an Adjuvant in Supraclavicular Block Assiut University January 1 2021 Phase 2
NCT04246333 Not yet recruiting Other: Mode of Delivery of Feeds BPD - Bronchopulmonary Dysplasia|VLBW - Very Low Birth Weight Infant|Feeding Disorder Neonatal|Feeding; Difficult Newborn|Premature Birth|Chronic Lung Disease of Prematurity Johns Hopkins All Children''s Hospital September 1 2020 Not Applicable
NCT04266977 Not yet recruiting Drug: Dexamethasone Glioblastoma|Dexamethasone|Steroids University Hospital Inselspital Berne April 2020 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID