Dexamethasone (DHAP)

Catalog No.S1322

Dexamethasone (DHAP) Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 10 Publications

3 Customer Reviews

  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

  • Effect of SENP2 overexpression on apoptosis-related proteins in CLL cells with or without dexamethasone treatment. (A and B) MEC2 cells in which SENP2 was overexpressed and the control cells were cultured in 6 cm dishes and then treated with dexamethasone for 24 h after reaching 70% confluence. Western blot analysis was then performed to inspect the expression levels of cleaved caspase-9, caspase-9, cleaved caspase-3, caspase-3, c-Myc, p53, Bax and Bcl-2 in these cells. GAPDH was used to confirm equal amount of proteins loaded in each lane. CLL, chronic lymphocytic leukemia; NC-OE-SENP2, MEC2 cells transfected with null (control) overexpression vector; OE-SENP2, MEC2 cells transfected with SENP2 overexpression vector; NC-shRNA-SENP2, MEC2 cells transfected with null control shRNA; shRNA-SENP2, MEC2 cells transfected with shRNA against SENP2; +, dexamethasone treatment, −, no dexamethasone treatment.

    Int J Oncol, 2018, doi:10.3892/ijo.2018.4635. Dexamethasone (DHAP) purchased from Selleck.

Purity & Quality Control

Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells NFXLPYhHfW6ldHnvckBie3OjeR?= M2LlTWFkfGm4aYT5JIF1KGi3bXHuJIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXjFiY3XscJMh[XO|ZYPz[YQh[XNicnXwdoV{e2mxbjDv[kBVVkZiYX7kJGlNNTFvYnX0ZU1qdmS3Y3XkJGUue2WuZXP0bY4h\2WwZTDlfJBz\XO|aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWQ2OD1yLkGgcm0> M2H4OlE5ODN{NkGw
HEK293 cells M3LuZmZ2dmO2aX;uJIF{e2G7 NH;0XYNFcXOybHHj[Y1mdnRib3[gX|NJZS2jbHTvd5Rmem:wZTDmdo9uKGi3bXHuJI1qdmW{YXzvZ49zfGmlb3nkJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOsJGtqRTBwM{[gcm0> MV:yOFQ1Pjd{OB?=
human PBMC MYLGeY5kfGmxbjDhd5NigQ>? MWrBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGDCUWMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBidnSrLVPEN{1qdmS3Y3XkJGdONUOVRjDwdo9lfWO2aX;uJIFnfGW{IES4JIhzeyxiRVO1NF0xNjR5IH7N MVeyN|E6QTR6NR?=
HFF cells MYXGeY5kfGmxbjDhd5NigQ>? NX;TUYRJSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNOSC|dHnteYxifGWmIFnMOkBxem:mdXP0bY9vKGmwIFjGSkBk\WyuczDifUB1emGwc4LldJJme3Orb36gZZN{[XluIFXDOVA:OC53IH7N NWe0bJQ6OTd4OUK1NVk>
human A549 cells Mk\ZSpVv[3Srb36gZZN{[Xl? MWTBZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGWoZnXjeEBwdiCJUlWgdJJwdW:2ZYKgdoV{eG:wc3WgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCjc4PhfUwhTUN3ME2xJI5O M4HQVFE3PjR|ME[w
NHDFneo cells MlKzSpVv[3Srb36gZZN{[Xl? NYTzXHBrSWO2aY\peJkh[XRiaIXtZY4hT1JiZYjwdoV{e2WmIHnuJG5JTE[wZX:gZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCLTD22JJBzd2S3Y4Tpc44tKEmFNUC9NU41KG6P NXPoR|RrOTd5MEWzOlI>
human HeLa cells NUnQRo45TnWwY4Tpc44h[XO|YYm= NUnOT2VlXHKjboPy[ZBz\XO|aX;uJIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yMY1m\GmjdHXkJIFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHRRSS2rbnT1Z4VlKGOxbHzh[4Vv[XOnIIDyc41wfGW{IHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF0yNjV6IH7N MoDnNlA4Ojd5NEO=
human SW1353 cells Mm\kSpVv[3Srb36gZZN{[Xl? MmjLWJJidnO{ZYDy[ZN{cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIGPXNVM2OyClZXzsd{Bie3Onc4Pl[EBieyC{ZYDy[ZN{cW:wIH;mJGlNNTFvaX7keYNm\CCPTWCtNVMheHKxZIXjeIlwdiCjZoTldkAzPCCqcoOgZpkhTUyLU1GsJGlEPTB;MT64JI5O Mlz1NlU4ODZzMEC=
rat polymorphonuclear leukocytes NIjndZBHfW6ldHnvckBie3OjeR?= MVWyNEBucW6| NYflOFdLSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiC{YYSgdI9tgW2xcoDoc452[2ynYYKgcIV2c2:leYTld{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2|dHnteYxifGWmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFIxKG2rboOgZpkhT3KrZYPzJI1mfGixZDygTWM2OD1{LkOgcm0> M3TKR|IzPTB4NkKw
human THP1 cells MoTISpVv[3Srb36gZZN{[Xl? M3G4T3Rz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVC16IIDyc4R2[3Srb36sJGlEPTB;Mj61NUBvVQ>? NGW4fW0zODd{N{e0Ny=>
human NP1 cells MUfGeY5kfGmxbjDhd5NigQ>? M1vFemFod26rc4SgZYN1cX[rdImgZZQhT1JibHnnZY5lKGKrbnTpcoch\G:vYXnuJIV5eHKnc4Pl[EBqdiCqdX3hckBPWDFiY3XscJMh[XO|ZYPz[YQh[XNiZ3z1Z49kd3K2aXPvbYQhemW|cH;ud4Uh\WynbXXueEB1emGwc3HjeIl3[XSrb36gZpkhT0GONDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9OE4zKG6P MYCxPVMzOTN2MR?=
human HeLa cells MWrGeY5kfGmxbjDhd5NigQ>? NVftWYw6XHKjboPhZ5RqfmG2aX;uJI9nKEeULVzCSEBmgHC{ZYPz[YQhcW5iaIXtZY4hUGWOYTDj[YxteyClbz3lfJBz\XO|aX7nJGdCVDRvRFLEJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD12LkKgcm0> M2fmbVI1ODFzNkS0
human 13D3/Huh7 cells MX3GeY5kfGmxbjDhd5NigQ>? MUiyOEBp MYLUdoFve2GldHn2ZZRqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iMUPEN{9JfWh5IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kB1gXKxc3nu[UBidWmwb4TyZY5{\mW{YYPlJIFkfGm4aYT5JIFnfGW{IEK0JIhzeyxiRVO1NF02KG6P MXGyNVA4OzF7MB?=
rat R1 cells MVzGeY5kfGmxbjDhd5NigQ>? NGHxV3kyOCEQvF2= NHP5bYgzPCCq MlfjTY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1odHWlb3PvdpRq[2:rZDDjc41xdGW6IITyZY5{\mWldHXkJIlvKHKjdDDSNUBk\WyuczDhd5Nme3OnZDDhd{Bld3ewLYLl[5Vt[XSrb36gc4YhXFCDLYLld5BwdnOrdnWg[YxmdWWwdDDwdo9qdm[uYX3tZZRwenliZ3Xu[UBmgHC{ZYPzbY9vKGG2IEGwJJVOKGGodHXyJFI1KGi{czDifUBj\XSjLXfhcIFkfG:|aXThd4Uh[XO|YYmsJGlEPTB;NTDuUS=> M3i3UFE5PDF{M{m3
human RPMI8226 cells MlX3VJJwdGmoZYLheIlwdiCjc4PhfS=> MYi0JIRigXN? MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFKSTVm4NlI3KGOnbHzzJIFnfGW{IESg[IF6eyxiSVO1NF03NjVibl2= MVqxO|cxPTN4Mh?=
african green monkey COS7 cells NUTI[phkTnWwY4Tpc44h[XO|YYm= M3vrOGFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1NSkRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVcvOiCwTR?= MljLNVk5PjNyOEO=
human PBMC NEjrU41HfW6ldHnvckBie3OjeR?= MXSyOEBp M2C1SWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gVGJOSyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFCKQT3pcoR2[2WmIFnGUodidW2jIIDyc4R2[3Srb36gZYZ1\XJiMkSgbJJ{ NH\UNpAzOzF7OUS4OS=>
human H13 cells NIPsPWxHfW6ldHnvckBie3OjeR?= M3nKb2lvcGmkaYTpc44hd2ZiZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUDF|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\2y3Y3;jc5J1cWOxaXStbY5lfWOnZDDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiMzDodpMh[nliW{PIYU11cHmvaXTpcoUhcW6lb4Lwc5JifGmxbjDhd5NigSxiRVO1NF06Njdibl2= MkfXNlMyQTl2OEW=
mouse RAW264.7 cells MnfjSpVv[3Srb36gZZN{[Xl? NEfUV2kyQCCq MmPyRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSk1idHCqYTDz[YNz\XSrb36gZYZ1\XJiMUigbJJ{NCCLQ{WwQVAvODFizszN M3\tcVIyOzV|NUSz
293 MSR cells MkXxSpVv[3Srb36gZZN{[Xl? NX7WRpVIPjBibXnudy=> NUj3ZWh2TGm|cHzhZ4Vu\W62IH;mJHs{UF1vZHX4ZY1mfGijc3;u[UBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCjbIDoZUBmgHC{ZYPz[YQhcW5iMkmzJG1UWiClZXzsd{Bi\nSncjC2NEBucW6|IHL5JJNkcW62aXzsZZRqd25iY3;1cpRqdmduIFXDOVA:OTJwNTDuUS=> MnfrNlMyQTl2OEW=
Sf9 cells MUnGeY5kfGmxbjDhd5NigQ>? Ml;BRolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDy[YNwdWKrbnHueEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiU3[5JINmdGy| M1TjeVIxPzJ5N{Sz
RAW 264.7 cells NFzqfVFHfW6ldHnvckBie3OjeR?= MmT5NlQhcA>? NFHje4dKdmirYnn0bY9vKG:oIHnueIVz\mW{b36g[4FudWFvc4TpcZVt[XSnZDDOU{Bxem:mdXP0bY9vKGmwIGLBW{AzPjRwNzDj[YxteyCjZoTldkAzPCCqcoOsJGlEPTB;MD6wNkDPxE1? MV2xO|M3PzF{NB?=
mouse J774A.1 cells M2nzWGZ2dmO2aX;uJIF{e2G7 NWP2VZU1UW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBVVk[jbIDoZUBxem:mdXP0bY9vKGmwIH3veZNmKEp5N{TBMlEh[2WubIOsJGlEPTB;NEigcm0> MV:xO|g6Ojl2MR?=
human HepG2 cells NVfqVWgzTnWwY4Tpc44h[XO|YYm= MWqyOEBp M2PoUmFkfGm4YYTpc44hd2ZicnH0JHBZWiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EBtfW2rbnXzZ4VvfCCjbnHsfZNqeyxiRVO1NF0zNjZizszN M1PvNFIxQTZ4MESz
human U2OS cells Moi1SpVv[3Srb36gZZN{[Xl? M{PWUVE5KGh? NXLEcmJPSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1NSkRiaX6gbJVu[W5iVULPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFfhcFQuTEKGIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHS{YX7zZYN1cX[jdHnvckBi[3Srdnn0fUBi\nSncjCxPEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE2Njh2OEmg{txO MXyyNFgyOjZ6MR?=
mouse thymocytes M{PnXWZ2dmO2aX;uJIF{e2G7 M3vWWlEh|ryP NGfUW|EzPCCq MXLJcoR2[3Srb36gc4Yh[XCxcITvd4l{KGmwIH3veZNmKHSqeX3vZ5l1\XNiYYPz[ZN{\WRiYYOgbY51\XKwdXPs[Y9{d22jbDDEUmEh\nKjZ33lcpRifGmxbjDheEAyKHWPIHHmeIVzKDJ2IHjyd{BjgSCjZ3Hyc5NmKGenbDDlcIVkfHKxcHjvdoV{cXN? NUewR3lqOjR5OUS3OFg>
human HMC1 cells M1:2e2Z2dmO2aX;uJIF{e2G7 M361T|EhcA>? MVLtcZVvd22xZIXsZZRwenliYXP0bZZqfHliaX6gbJVu[W5iSF3DNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIDoc5Jjd2xiMUKtcZlzcXO2YYTlJFE{NWGlZYTheIUwSTJ|MUi3MZN1cW23bHH0[YQhUUxzLXLleIEhe2WlcnX0bY9vKHS{ZXH0[YQhOSCqcjDwdolweiC2bzCzNEBucW6|IIDoc5Jjd2xiMUKtcZlzcXO2YYTlJFE{NWGlZYTheIUwSTJ|MUi3JINp[WyuZX7n[UBjgSCZZYP0[ZJvKGKub4T0bY5oKGGwYXz5d4l{ MnPyNlE{ODJ7Nke=
human monocytes MYrGeY5kfGmxbjDhd5NigQ>? MWG1JO69VQ>? Mnn4NlAhcA>? NFH6S2tCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJI1wdm:leYTld{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEORWEKg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEKwJIhzeyC3c3nu[{Bz[WKkaYSgdI9tgWOub37hcEBidnSrYn;kfUBK\0diYomgV2RUNVCDR1WgZY5idHm|aYO= MVqyNVg1Ozl|NR?=
COS7 cells MoK2SpVv[3Srb36gZZN{[Xl? MVKxJO69VQ>? M3XKfWFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgVVU4OEFibYX0ZY51KGmwIFPPV|ch[2WubIOgZZQhOSC3TTDifUBPTi2tYYDwZWIudHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 NGWyT3UyQDB|OEm3NC=>
human MDA-kb2 cells NHjqbmtHfW6ldHnvckBie3OjeR?= MoS0RYdwdmm|dDDhZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBqdiCqdX3hckBOTEFva3KyJINmdGy|IHHzd4V{e2WmIHHzJJN1cW23bHH0bY9vKG:oIHz1Z4ln\XKjc3WgZYN1cX[rdImgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7 M2TueFE6PTl{MkS1
human HeLaS3 cells MVrGeY5kfGmxbjDhd5NigQ>? NHrke3czKGh? Mn[3SIl{eGyjY3Xt[Y51KG:oIGuzTH1F\XijbXX0bIF{d26nIH\yc40h\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gTIVN[VN|IHPlcIx{KGGodHXyJFIhcHK| MYWyN|QxOzB6Mh?=

... Click to View More Cell Line Experimental Data

In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03183596 Withdrawn Pain Postoperative University of Alabama at Birmingham December 2019 Phase 3
NCT03183596 Withdrawn Pain Postoperative University of Alabama at Birmingham December 2019 Phase 3
NCT03210545 Not yet recruiting Addison Disease Göteborg University September 1 2019 Phase 4
NCT03210545 Not yet recruiting Addison Disease Göteborg University September 1 2019 Phase 4
NCT03571321 Not yet recruiting Acute Lymphoblastic Leukemia|ALL Childhood|ALL University of Chicago|Incyte Corporation September 5 2019 Phase 1
NCT03571321 Not yet recruiting Acute Lymphoblastic Leukemia|ALL Childhood|ALL University of Chicago|Incyte Corporation September 5 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

Related IL Receptor Products0

Tags: buy Dexamethasone (DHAP) | Dexamethasone (DHAP) ic50 | Dexamethasone (DHAP) price | Dexamethasone (DHAP) cost | Dexamethasone (DHAP) solubility dmso | Dexamethasone (DHAP) purchase | Dexamethasone (DHAP) manufacturer | Dexamethasone (DHAP) research buy | Dexamethasone (DHAP) order | Dexamethasone (DHAP) mouse | Dexamethasone (DHAP) chemical structure | Dexamethasone (DHAP) mw | Dexamethasone (DHAP) molecular weight | Dexamethasone (DHAP) datasheet | Dexamethasone (DHAP) supplier | Dexamethasone (DHAP) in vitro | Dexamethasone (DHAP) cell line | Dexamethasone (DHAP) concentration | Dexamethasone (DHAP) nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID