Dexamethasone (DHAP)

Catalog No.S1322

Dexamethasone (DHAP) Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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In DMSO USD 130 In stock
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Cited by 8 Publications

3 Customer Reviews

  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

  • Effect of SENP2 overexpression on apoptosis-related proteins in CLL cells with or without dexamethasone treatment. (A and B) MEC2 cells in which SENP2 was overexpressed and the control cells were cultured in 6 cm dishes and then treated with dexamethasone for 24 h after reaching 70% confluence. Western blot analysis was then performed to inspect the expression levels of cleaved caspase-9, caspase-9, cleaved caspase-3, caspase-3, c-Myc, p53, Bax and Bcl-2 in these cells. GAPDH was used to confirm equal amount of proteins loaded in each lane. CLL, chronic lymphocytic leukemia; NC-OE-SENP2, MEC2 cells transfected with null (control) overexpression vector; OE-SENP2, MEC2 cells transfected with SENP2 overexpression vector; NC-shRNA-SENP2, MEC2 cells transfected with null control shRNA; shRNA-SENP2, MEC2 cells transfected with shRNA against SENP2; +, dexamethasone treatment, −, no dexamethasone treatment.

    Int J Oncol, 2018, doi:10.3892/ijo.2018.4635. Dexamethasone (DHAP) purchased from Selleck.

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Biological Activity

Description Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells MnH3SpVv[3Srb36gZZN{[Xl? MVTBZ5Rqfmm2eTDheEBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR3YyKGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gWG5HKGGwZDDJUE0yNWKndHGtbY5lfWOnZDDFMZNmdGWldHnuJIdmdmViZYjwdoV{e2mxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXEOVA:OC5zIH7N MmOwNVgxOzJ4MUC=
HEK293 cells M2q2W2Z2dmO2aX;uJIF{e2G7 NVTMNmY4TGm|cHzhZ4Vu\W62IH;mJHs{UF1vYXzkc5N1\XKxbnWg[pJwdSCqdX3hckBucW6ncnHsc4NwenSrY3;p[EBz\WOncITvdkBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzMEBMcT1yLkO2JI5O MoTrNlQ1PDZ5Mki=
human PBMC MlH4SpVv[3Srb36gZZN{[Xl? MmLMRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDQRm1EKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[W62aT3DSFMucW6mdXPl[EBIVS2FU1[gdJJw\HWldHnvckBi\nSncjC0PEBpenNuIFXDOVA:OC52NzDuUS=> MnTMNlMyQTl2OEW=
HFF cells M2f6ZmZ2dmO2aX;uJIF{e2G7 M{nCOWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUFEhe3SrbYXsZZRm\CCLTE[gdJJw\HWldHnvckBqdiCKRl[gZ4VtdHNiYomgeJJidnO{ZYDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVAvPSCwTR?= MVixO|Y6OjVzOR?=
human A549 cells NYfJTXZFTnWwY4Tpc44h[XO|YYm= MVPBZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGWoZnXjeEBwdiCJUlWgdJJwdW:2ZYKgdoV{eG:wc3WgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCjc4PhfUwhTUN3ME2xJI5O MlvVNVY3PDNyNkC=
NHDFneo cells MoD1SpVv[3Srb36gZZN{[Xl? MYTBZ5Rqfmm2eTDheEBpfW2jbjDHVkBmgHC{ZYPz[YQhcW5iTljESo5mdyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNNTZicILv[JVkfGmxbjygTWM2OD1zLkSgcm0> MmrQNVc4ODV|NkK=
human HeLa cells MV\GeY5kfGmxbjDhd5NigQ>? M3ezUXRz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDUVGEucW6mdXPl[EBkd2yuYXflcoF{\SCycn;tc5RmeiCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NU42QCCwTR?= MmTaNlA4Ojd5NEO=
human SW1353 cells M1y4SGZ2dmO2aX;uJIF{e2G7 MUnUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iU2exN|U{KGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gTWwuOS2rbnT1Z4VlKE2PUD2xN{Bxem:mdXP0bY9vKGGodHXyJFI1KGi{czDifUBGVEmVQTygTWM2OD1zLkigcm0> NUi4ZYduOjV5ME[xNFA>
rat polymorphonuclear leukocytes NXXOd29iTnWwY4Tpc44h[XO|YYm= M{DpVlIxKG2rboO= MWfBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJJJifCCyb3z5cY9zeGixboXjcIVieiCuZYXrc4N6fGW|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gZYZ1\XJiMkCgcYlveyCkeTDHdolme3NibXX0bI9lNCCLQ{WwQVIvOyCwTR?= NXjvPJhpOjJ3ME[2NlA>
human THP1 cells MWPGeY5kfGmxbjDhd5NigQ>? NE\GWJNVemGwc4LldJJme3Orb36gZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KtcYVlcWG2ZXSgZY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhUUxvODDwdo9lfWO2aX;uMEBKSzVyPUKuOVEhdk1? NHXHZZczODd{N{e0Ny=>
human NP1 cells M2rEb2Z2dmO2aX;uJIF{e2G7 M3PWPWFod26rc4SgZYN1cX[rdImgZZQhT1JibHnnZY5lKGKrbnTpcoch\G:vYXnuJIV5eHKnc4Pl[EBqdiCqdX3hckBPWDFiY3XscJMh[XO|ZYPz[YQh[XNiZ3z1Z49kd3K2aXPvbYQhemW|cH;ud4Uh\WynbXXueEB1emGwc3HjeIl3[XSrb36gZpkhT0GONDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9OE4zKG6P M1;pVlE6OzJzM{Sx
human HeLa cells M1XQbmZ2dmO2aX;uJIF{e2G7 NUjPZ5BpXHKjboPhZ5RqfmG2aX;uJI9nKEeULVzCSEBmgHC{ZYPz[YQhcW5iaIXtZY4hUGWOYTDj[YxteyClbz3lfJBz\XO|aX7nJGdCVDRvRFLEJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD12LkKgcm0> MoTVNlQxOTF4NES=
human 13D3/Huh7 cells NWLkWWhDTnWwY4Tpc44h[XO|YYm= NX;KOHpLOjRiaB?= M1zzW3Rz[W6|YXP0bZZifGmxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjCxN2Q{N0i3aEegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKHS7cn;zbY5mKGGvaX7veJJidnOoZYLhd4Uh[WO2aY\peJkh[W[2ZYKgNlQhcHK|LDDFR|UxRTVibl2= M1vGOlIyODd|MUmw
rat R1 cells M2foS2Z2dmO2aX;uJIF{e2G7 NEPJfo0yOCEQvF2= NH\3T3MzPCCq NWjMN3JuUW6qaXLpeIlwdiCxZjDncJVkd2OxcoTpZ49q\CC{ZXPldJRwei2pbIXjc4NwenSrY3;p[EBkd22ybHX4JJRz[W6|ZnXjeIVlKGmwIILheEBTOSClZXzsd{Bie3Onc4Pl[EBieyCmb4fuMZJm\3WuYYTpc44hd2ZiVGDBMZJme3CxboPpeoUh\WynbXXueEBxem:rbn\sZY1u[XSxcomg[4Vv\SCneIDy[ZN{cW:wIHH0JFExKHWPIHHmeIVzKDJ2IHjyd{BjgSCkZYThMYdidGGldH;zbYRie2ViYYPzZZktKEmFNUC9OUBvVQ>? MUmxPFQyOjN7Nx?=
human RPMI8226 cells MWXQdo9tcW[ncnH0bY9vKGG|c3H5 MWS0JIRigXN? NHe1[5JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGLQUWk5OjJ4IHPlcIx{KGGodHXyJFQh\GG7czygTWM2OD14LkWgcm0> MWGxO|cxPTN4Mh?=
african green monkey COS7 cells Mk[5SpVv[3Srb36gZZN{[Xl? MUXB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHzp[4Fv\CCkaX7kbY5oKGSxbXHpckBmgHC{ZYPz[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR29UPyClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbEStUGJFKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME23MlIhdk1? M2fMTlE6QDZ|MEiz
human PBMC M1PkSGZ2dmO2aX;uJIF{e2G7 M3HOWFI1KGh? M4PT[mFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gVGJOSyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFCKQT3pcoR2[2WmIFnGUodidW2jIIDyc4R2[3Srb36gZYZ1\XJiMkSgbJJ{ MkThNlMyQTl2OEW=
human H13 cells NUC5cIFiTnWwY4Tpc44h[XO|YYm= Mn7zTY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBJOTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBodHWlb3PvdpRq[2:rZD3pcoR2[2WmIHPlcIwheHKxbHnm[ZJifGmxbjDh[pRmeiB|IHjyd{BjgSCdM1jdMZRpgW2rZHnu[UBqdmOxcoDvdoF1cW:wIHHzd4F6NCCHQ{WwQVkvPyCwTR?= M{TYVVI{OTl7NEi1
mouse RAW264.7 cells NFnvPZNHfW6ldHnvckBie3OjeR?= MkC3NVghcA>? M3e3b2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hdW:3c3WgVmFYOjZ2LkegZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDUUmYu[WyyaHGgd4VkemW2aX;uJIFnfGW{IEG4JIhzeyxiSVO1NF0xNjBzIN88US=> MXyyNVM2OzV2Mx?=
293 MSR cells MUfGeY5kfGmxbjDhd5NigQ>? NUjKUJdLPjBibXnudy=> MX;EbZNxdGGlZX3lcpQhd2ZiW{PIYU1l\XijbXX0bIF{d26nIHj1cYFvKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIFteGijIHX4dJJme3OnZDDpckAzQTNiTWPSJINmdGy|IHHmeIVzKDZyIH3pcpMh[nlic3PpcpRqdGyjdHnvckBkd3WwdHnu[{whTUN3ME2xNk42KG6P M3PLcFI{OTl7NEi1
Sf9 cells MXfGeY5kfGmxbjDhd5NigQ>? NYHIZnlESmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBz\WOxbXLpcoFvfCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4Y6KGOnbHzz M2\ZV|IxPzJ5N{Sz
RAW 264.7 cells NY[xOY1DTnWwY4Tpc44h[XO|YYm= Ml7HNlQhcA>? MV7Jcohq[mm2aX;uJI9nKGmwdHXy[oVzd25iZ3HtcYEue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJIlvKFKDVzCyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OC5yMjFOwG0> Ml6wNVc{PjdzMkS=
mouse J774A.1 cells NEm0cWtHfW6ldHnvckBie3OjeR?= M4D2VmlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckBqdiCvb4Xz[UBLPzd2QT6xJINmdGy|LDDJR|UxRTR6IH7N MXWxO|g6Ojl2MR?=
human HepG2 cells NYrWOHB6TnWwY4Tpc44h[XO|YYm= MXqyOEBp MXHBZ5RqfmG2aX;uJI9nKHKjdDDQXHIh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[mG|ZXSgcJVucW6nc3PlcpQh[W6jbInzbZMtKEWFNUC9Nk43KM7:TR?= NFm4PHkzODl4NkC0Ny=>
human U2OS cells NHTwNHlHfW6ldHnvckBie3OjeR?= M3jmelE5KGh? MXTB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{LVzCSEBqdiCqdX3hckBWOk:VIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghT2GuND3ERmQh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[geJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7IHHmeIVzKDF6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MUWuPFQ5QSEQvF2= M4D2clIxQDF{Nkix
mouse thymocytes MoLlSpVv[3Srb36gZZN{[Xl? M1qxWFEh|ryP M1;WT|I1KGh? MmG4TY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDtc5V{\SC2aIntc4N6fGW|IHHzd4V{e2WmIHHzJIlvfGW{boXjcIVwe2:vYXygSG5CKG[{YXft[Y51[XSrb36gZZQhOSC3TTDh[pRmeiB{NDDodpMh[nliYXfhdo9{\SCpZXyg[Yxm[3S{b4Doc5Jme2m| MnXUNlQ4QTR5NEi=
human HMC1 cells MVzGeY5kfGmxbjDhd5NigQ>? NEntTVIyKGh? NFnXfmxudXWwb33v[JVt[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gTG1EOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBpd3Kkb3ygNVIudXm{aYP0ZZRmKDF|LXHj[ZRifGVxQUKzNVg4NXO2aX31cIF1\WRiSVyxMYJmfGFic3XjdoV1cW:wIITy[YF1\WRiMTDodkBxemmxcjD0c{A{OCCvaX7zJJBpd3Kkb3ygNVIudXm{aYP0ZZRmKDF|LXHj[ZRifGVxQUKzNVg4KGOqYXzs[Y5o\SCkeTDX[ZN1\XKwIHLsc5R1cW6pIHHuZYx6e2m| NIC3NXczOTNyMkm2Oy=>
human monocytes MYrGeY5kfGmxbjDhd5NigQ>? M33Dc|Uh|ryP MoHTNlAhcA>? MljGRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDtc45w[3m2ZYOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBEV1h{IHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{MDDodpMhfXOrbnegdoFj[mm2IIDvcJlkdG:wYXygZY51cWKxZImgTYdIKGK7IGPEV{1RSUeHIHHuZYx6e2m| MkfUNlE5PDN7M{W=
COS7 cells MV;GeY5kfGmxbjDhd5NigQ>? MVKxJO69VQ>? NHvNNI5C\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJHE2PzCDIH31eIFvfCCrbjDDU3M4KGOnbHzzJIF1KDFidV2gZpkhVkZva3HwdIFDNWy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= M3jsZlE5ODN6OUew
human MDA-kb2 cells NFXWfIJHfW6ldHnvckBie3OjeR?= NHz4Z|ZC\2:waYP0JIFkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKE2GQT3rZlIh[2WubIOgZZN{\XO|ZXSgZZMhe3SrbYXsZZRqd25ib3[gcJVkcW[ncnHz[UBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYm= M2L1VFE6PTl{MkS1
human HeLaS3 cells MoO4SpVv[3Srb36gZZN{[Xl? MXyyJIg> MnfqSIl{eGyjY3Xt[Y51KG:oIGuzTH1F\XijbXX0bIF{d26nIH\yc40h\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gTIVN[VN|IHPlcIx{KGGodHXyJFIhcHK| NHLLdm4zOzRyM{C4Ni=>

... Click to View More Cell Line Experimental Data

In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03183596 Withdrawn Pain Postoperative University of Alabama at Birmingham December 2019 Phase 3
NCT03183596 Withdrawn Pain Postoperative University of Alabama at Birmingham December 2019 Phase 3
NCT03210545 Not yet recruiting Addison Disease Göteborg University September 1 2019 Phase 4
NCT03210545 Not yet recruiting Addison Disease Göteborg University September 1 2019 Phase 4
NCT03571321 Not yet recruiting Acute Lymphoblastic Leukemia|ALL Childhood|ALL University of Chicago|Incyte Corporation September 5 2019 Phase 1
NCT03571321 Not yet recruiting Acute Lymphoblastic Leukemia|ALL Childhood|ALL University of Chicago|Incyte Corporation September 5 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID