Dexamethasone

For research use only.

Catalog No.S1322

27 publications

Dexamethasone  Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.

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Selleck's Dexamethasone has been cited by 27 publications

Purity & Quality Control

Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells MnLrSpVv[3Srb36gZZN{[Xl? MV\BZ5Rqfmm2eTDheEBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR3YyKGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gWG5HKGGwZDDJUE0yNWKndHGtbY5lfWOnZDDFMZNmdGWldHnuJIdmdmViZYjwdoV{e2mxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXEOVA:OC5zIH7N MnPBNVgxOzJ4MUC=
HEK293 cells MU\GeY5kfGmxbjDhd5NigQ>? MlTLSIl{eGyjY3Xt[Y51KG:oIGuzTH0u[Wymb4P0[ZJwdmViZoLvcUBpfW2jbjDtbY5memGub3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|LDDLbV0xNjN4IH7N MnzsNlQ1PDZ5Mki=
human PBMC NVfQNYl3TnWwY4Tpc44h[XO|YYm= NYXReVN1SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBRSk2FIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiYX70bU1ETDNvaX7keYNm\CCJTT3DV2YheHKxZIXjeIlwdiCjZoTldkA1QCCqcoOsJGVEPTB;MD60O{BvVQ>? NYf4[JcxOjNzOUm0PFU>
HFF cells MXHGeY5kfGmxbjDhd5NigQ>? NFrpNmJCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gTWwyKHO2aX31cIF1\WRiSVy2JJBzd2S3Y4Tpc44hcW5iSF\GJINmdGy|IHL5JJRz[W6|cnXwdoV{e2mxbjDhd5NigSxiRVO1NF0xNjVibl2= MV:xO|Y6OjVzOR?=
human A549 cells M4XzS2Z2dmO2aX;uJIF{e2G7 M2Hq[WFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIFfSSUBxem:vb4TldkBz\XOyb37z[UBjgSCudXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCHQ{WwQVEhdk1? MkTHNVY3PDNyNkC=
NHDFneo cells NX\PWJVHTnWwY4Tpc44h[XO|YYm= M3LieWFkfGm4aYT5JIF1KGi3bXHuJGdTKGW6cILld5Nm\CCrbjDOTGRHdmWxIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhUUxvNjDwdo9lfWO2aX;uMEBKSzVyPUGuOEBvVQ>? MlvRNVc4ODV|NkK=
human HeLa cells M2rpRmZ2dmO2aX;uJIF{e2G7 M3vxWnRz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDUVGEucW6mdXPl[EBkd2yuYXflcoF{\SCycn;tc5RmeiCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEmFNUC9NU42QCCwTR?= NXjTSVY3OjB5Mke3OFM>
human SW1353 cells NWjkPZE6TnWwY4Tpc44h[XO|YYm= M{j4T3Rz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDTW|E{PTNiY3XscJMh[XO|ZYPz[YQh[XNicnXwdoV{e2mxbjDv[kBKVC1zLXnu[JVk\WRiTV3QMVE{KHC{b3T1Z5Rqd25iYX\0[ZIhOjRiaILzJIJ6KEWOSWPBMEBKSzVyPUGuPEBvVQ>? NH3zNYUzPTdyNkGwNC=>
rat polymorphonuclear leukocytes MYPGeY5kfGmxbjDhd5NigQ>? MXOyNEBucW6| M2LDe2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hemG2IIDvcJlud3KyaH;ueYNt\WG{IHzleYtw[3m2ZYOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCwaYTybYMhd3irZHWgdJJw\HWldHnvckBi\nSncjCyNEBucW6|IHL5JGdzcWW|czDt[ZRpd2RuIFnDOVA:Oi5|IH7N MUCyNlUxPjZ{MB?=
human THP1 cells Mo\hSpVv[3Srb36gZZN{[Xl? Ml;3WJJidnO{ZYDy[ZN{cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{LX3l[IlifGWmIHHueIlqdm[uYX3tZZRwenliYXP0bZZqfHliaX6gbJVu[W5iVFjQNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGlNNThicILv[JVkfGmxbjygTWM2OD1{LkWxJI5O NW[1dItCOjB5Mke3OFM>
human NP1 cells NF[4OVNHfW6ldHnvckBie3OjeR?= NInXZ|hC\2:waYP0JIFkfGm4aYT5JIF1KEeUIHzp[4Fv\CCkaX7kbY5oKGSxbXHpckBmgHC{ZYPz[YQhcW5iaIXtZY4hVlBzIHPlcIx{KGG|c3Xzd4VlKGG|IHfseYNw[2:{dHnjc4llKHKnc4DvcpNmKGWuZX3lcpQhfHKjboPhZ5RqfmG2aX;uJIJ6KEeDTESgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVQvOiCwTR?= MlGyNVk{OjF|NEG=
human HeLa cells MkXVSpVv[3Srb36gZZN{[Xl? M1flfnRz[W6|YXP0bZZifGmxbjDv[kBIWi2OQlSg[ZhxemW|c3XkJIlvKGi3bXHuJGhmVGFiY3XscJMh[29vZYjwdoV{e2mwZzDHRWw1NUSERDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:PC5{IH7N M4ro[|I1ODFzNkS0
human 13D3/Huh7 cells NWHzRW5LTnWwY4Tpc44h[XO|YYm= MoLYNlQhcA>? MYHUdoFve2GldHn2ZZRqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iMUPEN{9JfWh5IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kB1gXKxc3nu[UBidWmwb4TyZY5{\mW{YYPlJIFkfGm4aYT5JIFnfGW{IEK0JIhzeyxiRVO1NF02KG6P Mn63NlExPzNzOUC=
rat R1 cells M3nvb2Z2dmO2aX;uJIF{e2G7 NX7RepM5OTBizszN MonuNlQhcA>? M3vDfGlvcGmkaYTpc44hd2ZiZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5Iu\2y3Y3;jc5J1cWOxaXSgZ49ueGyneDD0doFve2[nY4Tl[EBqdiC{YYSgVlEh[2WubIOgZZN{\XO|ZXSgZZMh\G:5bj3y[Yd2dGG2aX;uJI9nKFSSQT3y[ZNxd26|aY\lJIVt\W2nboSgdJJwcW6obHHtcYF1d3K7IHflcoUh\XiycnXzd4lwdiCjdDCxNEB2VSCjZoTldkAzPCCqcoOgZpkh[mW2YT3nZYxi[3Sxc3nkZZNmKGG|c3H5MEBKSzVyPUWgcm0> MXmxPFQyOjN7Nx?=
human RPMI8226 cells MnfCVJJwdGmoZYLheIlwdiCjc4PhfS=> NGLY[Gc1KGSjeYO= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFKSTVm4NlI3KGOnbHzzJIFnfGW{IESg[IF6eyxiSVO1NF03NjVibl2= MWexO|cxPTN4Mh?=
african green monkey COS7 cells NIn1e3NHfW6ldHnvckBie3OjeR?= NWfEZ5N2SWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KEORU{egZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDHZYw1NUyERDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:Py5{IH7N M4OyNlE6QDZ|MEiz
human PBMC NGSydJhHfW6ldHnvckBie3OjeR?= NH24eFQzPCCq MorrRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDQRm1EKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWEiDLXnu[JVk\WRiSV\O[4FudWFicILv[JVkfGmxbjDh[pRmeiB{NDDodpM> MkfPNlMyQTl2OEW=
human H13 cells MX7GeY5kfGmxbjDhd5NigQ>? NV\GeHlkUW6qaXLpeIlwdiCxZjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCrbjDoeY1idiCKMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[E1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckBi\nSncjCzJIhzeyCkeTDbN2heNXSqeX3p[Ilv\SCrbnPvdpBwemG2aX;uJIF{e2G7LDDFR|UxRTlwNzDuUS=> MXeyN|E6QTR6NR?=
mouse RAW264.7 cells NHu0eW1HfW6ldHnvckBie3OjeR?= MlWzNVghcA>? NVT1dFh{SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTi2jbIDoZUB{\WO{ZYTpc44h[W[2ZYKgNVghcHK|LDDJR|UxRTBwMEGg{txO MojjNlE{PTN3NEO=
293 MSR cells M2fnNGZ2dmO2aX;uJIF{e2G7 M4XZdFYxKG2rboO= M4ezTmRqe3CuYXPlcYVvfCCxZjDbN2heNWSneHHt[ZRp[XOxbnWgbJVu[W5iZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5Ih[WyyaHGg[ZhxemW|c3XkJIlvKDJ7MzDNV3Ih[2WubIOgZYZ1\XJiNkCgcYlveyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCHQ{WwQVEzNjVibl2= MVOyN|E6QTR6NR?=
Sf9 cells M3PKcWZ2dmO2aX;uJIF{e2G7 NID2VXpDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJJJm[2:vYnnuZY51KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDT[lkh[2WubIO= MVSyNFczPzd2Mx?=
RAW 264.7 cells MUXGeY5kfGmxbjDhd5NigQ>? M2TZR|I1KGh? MmrlTY5pcWKrdHnvckBw\iCrboTldoZmem:wIHfhcY1iNXO2aX31cIF1\WRiTl:gdJJw\HWldHnvckBqdiCUQWegNlY1NjdiY3XscJMh[W[2ZYKgNlQhcHK|LDDJR|UxRTBwMEKg{txO MWWxO|M3PzF{NB?=
mouse J774A.1 cells MUnGeY5kfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSoFteGijIIDyc4R2[3Srb36gbY4hdW:3c3WgTlc4PEFwMTDj[YxteyxiSVO1NF01QCCwTR?= M{HPUlE4QDl{OUSx
human HepG2 cells NH;ZO2hHfW6ldHnvckBie3OjeR?= MXmyOEBp M1zMdWFkfGm4YYTpc44hd2ZicnH0JHBZWiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EBtfW2rbnXzZ4VvfCCjbnHsfZNqeyxiRVO1NF0zNjZizszN NYK4cmhYOjB7Nk[wOFM>
human U2OS cells M3HjOWZ2dmO2aX;uJIF{e2G7 M3T0cFE5KGh? NUD3UnJWSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1NSkRiaX6gbJVu[W5iVULPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFfhcFQuTEKGIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHS{YX7zZYN1cX[jdHnvckBi[3Srdnn0fUBi\nSncjCxPEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE2Njh2OEmg{txO NIfu[nczODhzMk[4NS=>
mouse thymocytes M1nQb2Z2dmO2aX;uJIF{e2G7 M{[yZ|Eh|ryP MmO2NlQhcA>? NVv5TopOUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBud3W|ZTD0bJlud2O7dHXzJIF{e2W|c3XkJIF{KGmwdHXycpVkdGWxc3;tZYwhTE6DIH\yZYdu\W62YYTpc44h[XRiMTD1UUBi\nSncjCyOEBpenNiYomgZYdiem:|ZTDn[Ywh\WynY4Tyc5Bpd3Knc3nz NX\vbmtqOjR5OUS3OFg>
human HMC1 cells MWXGeY5kfGmxbjDhd5NigQ>? NGLwTJQyKGh? M2DWd41ufW6xbX;keYxifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDIUWMyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdIhwemKxbDCxNk1ugXKrc4TheIUhOTNvYXPleIF1\S:DMkOxPFcue3SrbYXsZZRm\CCLTEGtZoV1[SC|ZXPy[ZRqd25idILlZZRm\CBzIHjyJJBzcW:{IITvJFMxKG2rboOgdIhwemKxbDCxNk1ugXKrc4TheIUhOTNvYXPleIF1\S:DMkOxPFch[2ijbHzlcodmKGK7IGfld5Rmem5iYnzveJRqdmdiYX7hcJl{cXN? NHXqOXIzOTNyMkm2Oy=>
human monocytes NH3nbYFHfW6ldHnvckBie3OjeR?= NEWwR5A2KM7:TR?= MoPvNlAhcA>? MY\BcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIH3vco9kgXSnczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJGNQYDJiZYjwdoV{e2mxbjDheEA2KHWPIHHmeIVzKDJyIHjyd{B2e2mwZzDyZYJjcXRicH;sfYNtd26jbDDhcpRq[m:meTDJ[2ch[nliU1TTMXBCT0ViYX7hcJl{cXN? NXvyO5k3OjF6NEO5N|U>
COS7 cells NXz1eXJXTnWwY4Tpc44h[XO|YYm= MYOxJO69VQ>? NXXGRY1TSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBSPTdyQTDteZRidnRiaX6gR29UPyClZXzsd{BifCBzIIXNJIJ6KE6ILXvhdJBiSi2udXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYm= MU[xPFA{QDl5MB?=
human MDA-kb2 cells NGju[4FHfW6ldHnvckBie3OjeR?= NEiyfnlC\2:waYP0JIFkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKE2GQT3rZlIh[2WubIOgZZN{\XO|ZXSgZZMhe3SrbYXsZZRqd25ib3[gcJVkcW[ncnHz[UBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYm= NX31TXBvOTl3OUKyOFU>
human HeLaS3 cells M3\xPGZ2dmO2aX;uJIF{e2G7 Ml7kNkBp NF;EVIJFcXOybHHj[Y1mdnRib3[gX|NJZUSneHHt[ZRp[XOxbnWg[pJwdSCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBJ\UyjU{OgZ4VtdHNiYX\0[ZIhOiCqcoO= NFzCUGczOzRyM{C4Ni=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bcl-xl / Mcl-1 / Survivin / IAP1 ; 

PubMed: 28696369     


Bcl-xl, Bcl-2, Survivin, Mcl-1, and IAP1 protein levels were determined via Western blot analysis.

Cyclin D1 / Cyclin E / COX-2 / MMP-9 ; 

PubMed: 28696369     


Cyclin D1, Cyclin E, COX-2, and MMP-9 protein levels were determined via Western blot analysis.

Bax / p21; 

PubMed: 28696369     


The protein levels of Bax and p21 were determined via Western blot analysis.

p-JNK / JNK / p-p38 / p38 / p-ERK / ERK ; 

PubMed: 28696369     


The cells were treated with 100 μM of DHAP for the time periods stated; whole-cell extracts were then prepared and analyzed via Western blot analysis for p-p38 (Thr180/Tyr182), p-JNK (Thr183/Tyr185), and p-ERK1/2 (Thr202/Tyr204) by Western blot analysis. To confirm equal protein loading, the immunoblot was stripped and reprobed for JNK, p38, and ERK1/2. The results shown are representative of the three independent experiments

28696369
In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Water Insoluble
Ethanol '''6 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04345588 Not yet recruiting Drug: Dexamethasone injection Dexamethasone Efficacy as an Adjuvant in Supraclavicular Block Assiut University January 1 2021 Phase 2
NCT04246333 Not yet recruiting Other: Mode of Delivery of Feeds BPD - Bronchopulmonary Dysplasia|VLBW - Very Low Birth Weight Infant|Feeding Disorder Neonatal|Feeding; Difficult Newborn|Premature Birth|Chronic Lung Disease of Prematurity Johns Hopkins All Children''s Hospital September 1 2020 Not Applicable
NCT04266977 Not yet recruiting Drug: Dexamethasone Glioblastoma|Dexamethasone|Steroids University Hospital Inselspital Berne April 2020 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID