Dexamethasone

For research use only.

Catalog No.S1322

34 publications

Dexamethasone  Chemical Structure

CAS No. 50-02-2

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.

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Selleck's Dexamethasone has been cited by 34 publications

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Biological Activity

Description Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells MW\GeY5kfGmxbjDhd5NigQ>? MYPBZ5Rqfmm2eTDheEBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR3YyKGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gWG5HKGGwZDDJUE0yNWKndHGtbY5lfWOnZDDFMZNmdGWldHnuJIdmdmViZYjwdoV{e2mxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXEOVA:OC5zIH7N NV7ne49xOThyM{K2NVA>
HEK293 cells Mkm0SpVv[3Srb36gZZN{[Xl? MnrrSIl{eGyjY3Xt[Y51KG:oIGuzTH0u[Wymb4P0[ZJwdmViZoLvcUBpfW2jbjDtbY5memGub3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|LDDLbV0xNjN4IH7N MWmyOFQ1Pjd{OB?=
human PBMC MXvGeY5kfGmxbjDhd5NigQ>? NYHxXFdsSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBRSk2FIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiYX70bU1ETDNvaX7keYNm\CCJTT3DV2YheHKxZIXjeIlwdiCjZoTldkA1QCCqcoOsJGVEPTB;MD60O{BvVQ>? M1H0UlI{OTl7NEi1
HFF cells NEfRVFlHfW6ldHnvckBie3OjeR?= MlTiRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFnMNUB{fGmvdXzheIVlKEmONjDwdo9lfWO2aX;uJIlvKEiIRjDj[YxteyCkeTD0doFve3KncILld5Nqd25iYYPzZZktKEWFNUC9NE42KG6P NXjHTY5IOTd4OUK1NVk>
human A549 cells NWjuUIRqTnWwY4Tpc44h[XO|YYm= NUHvN3Z3SWO2aY\peJkh[XRiZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hSTV2OTDj[YxteyCjc4Pld5Nm\CCjczDl[oZm[3Rib36gS3JGKHC{b33veIVzKHKnc4DvcpNmKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKgZZN{[XluIFXDOVA:OSCwTR?= M1X4UlE3PjR|ME[w
NHDFneo cells Ml7pSpVv[3Srb36gZZN{[Xl? NFHafpRC[3Srdnn0fUBifCCqdX3hckBIWiCneIDy[ZN{\WRiaX6gUmhFTm6nbzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEmOLU[gdJJw\HWldHnvckwhUUN3ME2xMlQhdk1? MVqxO|cxPTN4Mh?=
human HeLa cells MkHISpVv[3Srb36gZZN{[Xl? MYPUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgZ49tdGGpZX7hd4UheHKxbX;0[ZIh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUGuOVghdk1? MWeyNFczPzd2Mx?=
human SW1353 cells NVXIbVd6TnWwY4Tpc44h[XO|YYm= MkLkWJJidnO{ZYDy[ZN{cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIGPXNVM2OyClZXzsd{Bie3Onc4Pl[EBieyC{ZYDy[ZN{cW:wIH;mJGlNNTFvaX7keYNm\CCPTWCtNVMheHKxZIXjeIlwdiCjZoTldkAzPCCqcoOgZpkhTUyLU1GsJGlEPTB;MT64JI5O MlrpNlU4ODZzMEC=
rat polymorphonuclear leukocytes M4r3SGZ2dmO2aX;uJIF{e2G7 MX6yNEBucW6| MoHKRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBz[XRicH;sfY1wenCqb371Z4xm[XJibHX1b49kgXSnczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKG6rdILpZ{BwgGmmZTDwdo9lfWO2aX;uJIFnfGW{IEKwJI1qdnNiYomgS5Jq\XO|IH3leIhw\CxiSVO1NF0zNjNibl2= M1zZNlIzPTB4NkKw
human THP1 cells MnfpSpVv[3Srb36gZZN{[Xl? M1[3cXRz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVC16IIDyc4R2[3Srb36sJGlEPTB;Mj61NUBvVQ>? MnfpNlA4Ojd5NEO=
human NP1 cells MlzsSpVv[3Srb36gZZN{[Xl? MYLB[49vcXO2IHHjeIl3cXS7IHH0JGdTKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbjDlfJBz\XO|ZXSgbY4hcHWvYX6gUnAyKGOnbHzzJIF{e2W|c3XkJIF{KGeudXPvZ49zfGmlb3nkJJJme3CxboPlJIVt\W2nboSgeJJidnOjY4TpeoF1cW:wIHL5JGdCVDRibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUSuNkBvVQ>? MnrzNVk{OjF|NEG=
human HeLa cells MUXGeY5kfGmxbjDhd5NigQ>? M4G0bnRz[W6|YXP0bZZifGmxbjDv[kBIWi2OQlSg[ZhxemW|c3XkJIlvKGi3bXHuJGhmVGFiY3XscJMh[29vZYjwdoV{e2mwZzDHRWw1NUSERDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:PC5{IH7N NFnM[JgzPDBzMU[0OC=>
human 13D3/Huh7 cells M33sXGZ2dmO2aX;uJIF{e2G7 NVrjOXF3OjRiaB?= MUHUdoFve2GldHn2ZZRqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iMUPEN{9JfWh5IHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kB1gXKxc3nu[UBidWmwb4TyZY5{\mW{YYPlJIFkfGm4aYT5JIFnfGW{IEK0JIhzeyxiRVO1NF02KG6P NUnOc|FXOjFyN{OxPVA>
rat R1 cells NFXnVJpHfW6ldHnvckBie3OjeR?= MnzCNVAh|ryP NXfnWFU2OjRiaB?= Ml;OTY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1odHWlb3PvdpRq[2:rZDDjc41xdGW6IITyZY5{\mWldHXkJIlvKHKjdDDSNUBk\WyuczDhd5Nme3OnZDDhd{Bld3ewLYLl[5Vt[XSrb36gc4YhXFCDLYLld5BwdnOrdnWg[YxmdWWwdDDwdo9qdm[uYX3tZZRwenliZ3Xu[UBmgHC{ZYPzbY9vKGG2IEGwJJVOKGGodHXyJFI1KGi{czDifUBj\XSjLXfhcIFkfG:|aXThd4Uh[XO|YYmsJGlEPTB;NTDuUS=> NVzKXG9ZOTh2MUKzPVc>
human RPMI8226 cells NWXyPZkxWHKxbHnm[ZJifGmxbjDhd5NigQ>? MUG0JIRigXN? M{HzNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUmDNTVgzOjZiY3XscJMh[W[2ZYKgOEBl[Xm|LDDJR|UxRTZwNTDuUS=> M4HKUlE4PzB3M{[y
african green monkey COS7 cells MVrGeY5kfGmxbjDhd5NigQ>? NXzrfnA4SWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KEORU{egZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDHZYw1NUyERDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:Py5{IH7N MY[xPVg3OzB6Mx?=
human PBMC MWjGeY5kfGmxbjDhd5NigQ>? MkTINlQhcA>? NY\UXG17SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBRSk2FIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiUFjBMYlv\HWlZXSgTWZP\2GvbXGgdJJw\HWldHnvckBi\nSncjCyOEBpenN? NULmS4pTOjNzOUm0PFU>
human H13 cells MVzGeY5kfGmxbjDhd5NigQ>? NGLS[2RKdmirYnn0bY9vKG:oIHfseYNw[2:{dHnjc4llKHKnY3XweI9zKGmwIHj1cYFvKEhzMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGeudXPvZ49zfGmlb3nkMYlv\HWlZXSgZ4VtdCCycn;sbYZmemG2aX;uJIFnfGW{IEOgbJJ{KGK7IGuzTH0ufGi7bXnkbY5mKGmwY3;ydI9z[XSrb36gZZN{[XluIFXDOVA:QS55IH7N MV:yN|E6QTR6NR?=
mouse RAW264.7 cells MWjGeY5kfGmxbjDhd5NigQ>? NHPMVWMyQCCq MoH1RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSk1idHCqYTDz[YNz\XSrb36gZYZ1\XJiMUigbJJ{NCCLQ{WwQVAvODFizszN NGXqNGszOTN3M{W0Ny=>
293 MSR cells MXLGeY5kfGmxbjDhd5NigQ>? M{\telYxKG2rboO= MoDUSIl{eGyjY3Xt[Y51KG:oIGuzTH0u\GW6YX3leIhie2:wZTDoeY1idiCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBidHCqYTDlfJBz\XO|ZXSgbY4hOjl|IF3TVkBk\WyuczDh[pRmeiB4MDDtbY5{KGK7IIPjbY51cWyuYYTpc44h[2:3boTpcoctKEWFNUC9NVIvPSCwTR?= M2jNSFI{OTl7NEi1
Sf9 cells Mn63SpVv[3Srb36gZZN{[Xl? MWjCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlZ49u[mmwYX70JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgZ4VtdHN? NVLkc2hmOjB5Mke3OFM>
RAW 264.7 cells M4TOSGZ2dmO2aX;uJIF{e2G7 NFzLb3QzPCCq MU\Jcohq[mm2aX;uJI9nKGmwdHXy[oVzd25iZ3HtcYEue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJIlvKFKDVzCyOlQvPyClZXzsd{Bi\nSncjCyOEBpenNuIFnDOVA:OC5yMjFOwG0> M1L4R|E4OzZ5MUK0
mouse J774A.1 cells NHLkTIdHfW6ldHnvckBie3OjeR?= NGnxc5VKdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTmGucHjhJJBzd2S3Y4Tpc44hcW5ibX;1d4UhUjd5NFGuNUBk\WyuczygTWM2OD12ODDuUS=> MUSxO|g6Ojl2MR?=
human HepG2 cells MkPMSpVv[3Srb36gZZN{[Xl? NGPS[lAzPCCq M1XwTmFkfGm4YYTpc44hd2ZicnH0JHBZWiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EBtfW2rbnXzZ4VvfCCjbnHsfZNqeyxiRVO1NF0zNjZizszN NIewc|EzODl4NkC0Ny=>
human U2OS cells NH;vWmZHfW6ldHnvckBie3OjeR?= Ml75NVghcA>? NV;CeXN2SWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1NSkRiaX6gbJVu[W5iVULPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFfhcFQuTEKGIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHS{YX7zZYN1cX[jdHnvckBi[3Srdnn0fUBi\nSncjCxPEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE2Njh2OEmg{txO NUC2cJhFOjB6MUK2PFE>
mouse thymocytes NV3rXoxrTnWwY4Tpc44h[XO|YYm= NIXGZW4yKM7:TR?= NU\Pd402OjRiaB?= NX\TNHVPUW6mdXP0bY9vKG:oIHHwc5B1d3OrczDpckBud3W|ZTD0bJlud2O7dHXzJIF{e2W|c3XkJIF{KGmwdHXycpVkdGWxc3;tZYwhTE6DIH\yZYdu\W62YYTpc44h[XRiMTD1UUBi\nSncjCyOEBpenNiYomgZYdiem:|ZTDn[Ywh\WynY4Tyc5Bpd3Knc3nz MoLvNlQ4QTR5NEi=
human HMC1 cells MV3GeY5kfGmxbjDhd5NigQ>? NUHHWHhpOSCq MmXpcY12dm:vb3T1cIF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFjNR|Eh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDwbI9z[m:uIEGyMY16emm|dHH0[UAyOy2jY3X0ZZRmN0F{M{G4O{1{fGmvdXzheIVlKEmOMT3i[ZRiKHOnY4LleIlwdiC2cnXheIVlKDFiaIKgdJJqd3JidH:gN|AhdWmwczDwbI9z[m:uIEGyMY16emm|dHH0[UAyOy2jY3X0ZZRmN0F{M{G4O{BkcGGubHXu[4Uh[nliV3XzeIVzdiCkbH;0eIlv\yCjbnHsfZNqew>? M3GxVVIyOzB{OU[3
human monocytes M1rFXmZ2dmO2aX;uJIF{e2G7 MY[1JO69VQ>? NVLhOmxoOjBiaB?= MoK3RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDtc45w[3m2ZYOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBEV1h{IHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{MDDodpMhfXOrbnegdoFj[mm2IIDvcJlkdG:wYXygZY51cWKxZImgTYdIKGK7IGPEV{1RSUeHIHHuZYx6e2m| MVKyNVg1Ozl|NR?=
COS7 cells NUW1eIRCTnWwY4Tpc44h[XO|YYm= NFrOXWIyKM7:TR?= Mn\DRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDROVcxSSCvdYThcpQhcW5iQ1;TO{Bk\WyuczDheEAyKHWPIHL5JG5HNWujcIDhRk1tfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? NX3kT|E6OThyM{i5O|A>
human MDA-kb2 cells NHvQXohHfW6ldHnvckBie3OjeR?= M3fDbGFod26rc4SgZYN1cX[rdImgZZQh[W6mcn;n[Y4hemWlZYD0c5IhcW5iaIXtZY4hVUSDLXviNkBk\WyuczDhd5Nme3OnZDDhd{B{fGmvdXzheIlwdiCxZjDseYNq\mW{YYPlJIFkfGm4aYT5JIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= NEPUcIkyQTV7MkK0OS=>
human HeLaS3 cells MoLNSpVv[3Srb36gZZN{[Xl? M2jkPFIhcA>? MlXCSIl{eGyjY3Xt[Y51KG:oIGuzTH1F\XijbXX0bIF{d26nIH\yc40h\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gTIVN[VN|IHPlcIx{KGGodHXyJFIhcHK| MWKyN|QxOzB6Mh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Bcl-2 / Bcl-xl / Mcl-1 / Survivin / IAP1 ; 

PubMed: 28696369     


Bcl-xl, Bcl-2, Survivin, Mcl-1, and IAP1 protein levels were determined via Western blot analysis.

Cyclin D1 / Cyclin E / COX-2 / MMP-9 ; 

PubMed: 28696369     


Cyclin D1, Cyclin E, COX-2, and MMP-9 protein levels were determined via Western blot analysis.

Bax / p21; 

PubMed: 28696369     


The protein levels of Bax and p21 were determined via Western blot analysis.

p-JNK / JNK / p-p38 / p38 / p-ERK / ERK ; 

PubMed: 28696369     


The cells were treated with 100 μM of DHAP for the time periods stated; whole-cell extracts were then prepared and analyzed via Western blot analysis for p-p38 (Thr180/Tyr182), p-JNK (Thr183/Tyr185), and p-ERK1/2 (Thr202/Tyr204) by Western blot analysis. To confirm equal protein loading, the immunoblot was stripped and reprobed for JNK, p38, and ERK1/2. The results shown are representative of the three independent experiments

28696369
In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Water Insoluble
Ethanol '''6 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04345588 Not yet recruiting Drug: Dexamethasone injection Dexamethasone Efficacy as an Adjuvant in Supraclavicular Block Assiut University January 1 2021 Phase 2
NCT03660072 Not yet recruiting Other: Non-Interventional Multiple Myeloma Bristol-Myers Squibb January 31 2021 --
NCT04246333 Not yet recruiting Other: Mode of Delivery of Feeds BPD - Bronchopulmonary Dysplasia|VLBW - Very Low Birth Weight Infant|Feeding Disorder Neonatal|Feeding; Difficult Newborn|Premature Birth|Chronic Lung Disease of Prematurity Johns Hopkins All Children''s Hospital September 1 2020 Not Applicable
NCT04529512 Not yet recruiting Drug: DEXTENZA® Ocular Disease Requiring Surgery Nathan Steinle|Ocular Therapeutix Inc.|California Retina Consultants August 2020 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID