Fenofibrate (NSC-281319)

Catalog No.S1794

For research use only.

Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.

Fenofibrate (NSC-281319) Chemical Structure

CAS No. 49562-28-9

Selleck's Fenofibrate (NSC-281319) has been cited by 10 Publications

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Purity & Quality Control

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Biological Activity

Description Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Targets
PPARα [1] CYP2C19 [3]
(Cell-free assay)
CYP2B6 [3]
(Cell-free assay)
CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

10mg/mL

Chemical Information

Molecular Weight 360.83
Formula

C20H21ClO4

CAS No. 49562-28-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04650152 Completed Drug: Tricor (fenofibrate) 145 mg film-coated tablet Hypertriglyceridemia|Metabolic Syndrome Abbott October 27 2020 --
NCT03869931 Recruiting Drug: Fenofibrate Diabetes Mellitus|Diabetic Nephropathies Singapore General Hospital|National Medical Research Council (NMRC) Singapore March 8 2019 Phase 3
NCT03557983 Unknown status Drug: Fenofibrate|Drug: Saline Radiodermatitis Second Affiliated Hospital of Soochow University June 13 2018 Not Applicable
NCT03515213 Active not recruiting Drug: Fenofibrate|Drug: Placebo Huntington Disease University of California Irvine April 27 2017 Phase 2
NCT02891408 Completed Drug: Firsocostat|Drug: Fenofibrate Nonalcoholic Steatohepatitis (NASH) Gilead Sciences September 23 2016 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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