Fenofibrate (NSC-281319)

For research use only.

Catalog No.S1794

9 publications

Fenofibrate (NSC-281319) Chemical Structure

CAS No. 49562-28-9

Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.

Selleck's Fenofibrate (NSC-281319) has been cited by 9 publications

2 Customer Reviews

  • E. The mTOR-lipin1-SREBP1 pathway in the liver of the Rab8af/f and Rab8a-mKO female mice gavaged with fenofibrate (25 mg/kg) or vehicle (H2O) for 8 days. F. mRNA expression of key genes in lipid metabolism in the liver of the Rab8af/f and Rab8a-mKO female mice gavaged with fenofibrate or vehicle for 8 days. n = 4-6. Statistical analyses were carried out using two-way ANOVA. * indicates p <0.05. n.s., not significant.

    Diabetes, 2017, 66(9):2387-2399. Fenofibrate (NSC-281319) purchased from Selleck.

    E, protein expression of ABCG1, ABCA1 and SR-B1; F, densitometric quantification of ABCG1; G, densitometric quantification of ABCA1; H, densitometric quantification of SR-B1. FB: fenofibrate; B: blank control. Data are expressed as the mean ± SD. * p < 0.05 vs. blank control group; ** p < 0.01 vs. blank control group; # p < 0.05 vs. FB group.

    Food Funct, 2018, 9(12):6608-6617. Fenofibrate (NSC-281319) purchased from Selleck.

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Biological Activity

Description Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Targets
PPARα [1]
()
CYP2C19 [3]
(Cell-free assay)
CYP2B6 [3]
(Cell-free assay)
CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM

Protocol

Solubility (25°C)

In vitro DMSO 72 mg/mL (199.53 mM)
Water Insoluble
Ethanol '46 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 360.83
Formula

C20H21ClO4

CAS No. 49562-28-9
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04650152 Recruiting Drug: Tricor (fenofibrate) 145 mg film-coated tablet Hypertriglyceridemia|Metabolic Syndrome Abbott October 27 2020 --
NCT03869931 Recruiting Drug: Fenofibrate Diabetes Mellitus|Diabetic Nephropathies Singapore General Hospital|National Medical Research Council (NMRC) Singapore March 8 2019 Phase 3
NCT03557983 Unknown status Drug: Fenofibrate|Drug: Saline Radiodermatitis Second Affiliated Hospital of Soochow University June 13 2018 Not Applicable
NCT03515213 Active not recruiting Drug: Fenofibrate|Drug: Placebo Huntington Disease University of California Irvine April 27 2017 Phase 2
NCT02891408 Completed Drug: Firsocostat|Drug: Fenofibrate Nonalcoholic Steatohepatitis (NASH) Gilead Sciences September 23 2016 Phase 1

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PPAR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID