Vorinostat (SAHA)

For research use only.

Catalog No.S1047 Synonyms: MK0683

309 publications

Vorinostat (SAHA) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

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Selleck's Vorinostat (SAHA) has been cited by 309 publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NWfH[IxtU2mwYYPlJGF{e2G7 MlPpNUBp NVXwcXpkTE2VTx?= MXrhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? MojSNVE6PjB2OEm=
Friend leukemic cell MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTPOVAh|ryP M3u0blczKGh? MXnEUXNQ NIrzSVRKSzVyPUCuPVkh|ryP M2PPS|EzOTB7OUGz
K562 M1Xrc2tqdmG|ZTDBd5NigQ>? NH23Uo83KGh? MYXEUXNQ NGLYfXJKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> NEfnOIEyOjRzOUO4NC=>
HT1080 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn4NI9[PzJiaB?= MV;EUXNQ MWDJR|UxRTJwNDFOwG0> MX:xNlI4ODF5NR?=
H1299 MWTLbY5ie2ViQYPzZZk> MUOyNEBucW5? NXXBPY9rTE2VTx?= M1nqR2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN MVmxOFUzOTR{Mh?=
H1299 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz1UVdbPzJiaB?= NHTpZWhFVVOR MYfJR|UxRTdwMkSg{txO M{DxZ|E1PTJzNEKy
HeLa M2jqUmtqdmG|ZTDBd5NigQ>? NHS3Xo0{OCCvaX6= MVHJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> NUftfHR6OTV4MEO5OFk>
LOX-IMVI NFXYbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33ROVQ5KGh? NFTRdWhKSzVyPUGuN{DPxE1? NHP1Um8yPTdzNUS3NC=>
NCI-H226 NHToZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnjOFghcA>? M3vjOGlEPTB;Mj62JO69VQ>? NYq4dGkxOTV5MUW0O|A>
RXF-631L NVzhXmY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi1OFghcA>? MmrrTWM2OD1{IN88US=> NFjBOGwyPTdzNUS3NC=>
SNB-78 NEjSPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHG1cIM1QCCq NVLaVYFZUUN3ME2xOkDPxE1? NE\zU44yPTdzNUS3NC=>
St-4 NYi5Z|gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DiNFQ5KGh? NYG5ZpE{UUN3ME21MlIh|ryP MoG1NVU4OTV2N{C=
ARP1 MlGwSpVv[3Srb36gRZN{[Xl? NGH5NI4zKM7:TR?= M4fSTVYhcA>? Mn;1TY5lfWO2aX;uJI9nKFB{MWfBSlEh\2WwZTDlfJBz\XO|aX;u Mm\TNVQ4OzR6ME[=
CEM NHXj[YhMcW6jc3WgRZN{[Xl? NIm1WmEyKGh? M3nUNWROW09? MoWzTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? MXixOlQzODB4NB?=
HCT15 M3jscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPLc2dyPDhiaB?= NXz5d|JMT0l3ME2wMlgzKM7:TR?= MlTDNVY4OjN{Mke=
NCI-H23 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHpOIdNPDhiaB?= M3P5UGdKPTB;MD65NkDPxE1? M2\1PVE3PzJ|MkK3
GM15850 NHrhbnFMcW6jc3WgRZN{[Xl? NHfqdHUzNjVizszN MWO5OkBp M4LC[mROW09? NWDQOVdwUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MVmxOlkzOTN4Nx?=
GM15850 NYDUcIxFU2mwYYPlJGF{e2G7 MYSyMlUh|ryP M2CzWVk3KGh? NXPGPGlvTE2VTx?= NX;YOWlWUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NGHo[W8yPjl{MUO2Oy=>
GM15850 NHzaXZhMcW6jc3WgRZN{[Xl? NXjsSll2Oi53IN88US=> NYrSZ3pLQTZiaB?= MYfEUXNQ M3vPcmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NWPRXpE5OTZ7MkGzOlc>
GM15850 NFvONYxMcW6jc3WgRZN{[Xl? MWmyMlUh|ryP MlvoPVYhcA>? MVXEUXNQ NYfzZYVTUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWLDWG9MOTZ7MkGzOlc>
GM15850 M{TM[2tqdmG|ZTDBd5NigQ>? M3nOXlIvPSEQvF2= M1LFd|k3KGh? MV7EUXNQ M1v6S2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NFHMfYYyPjl{MUO2Oy=>
GM15850 M3\ldmtqdmG|ZTDBd5NigQ>? MmXvNk42KM7:TR?= NE[5ZYQ6PiCq NEHqR3ZFVVOR NULBVnVlUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M{fWdlE3QTJzM{[3
U937 NVfMTVFbTnWwY4Tpc44hSXO|YYm= MYW1JO69VQ>? NWGxbW5lOjRiaB?= NWK1bmJnTE2VTx?= NYrYPWlNS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= NUj0XnpwOTdyMES3NVg>
H661 M4TDOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXx[Vk1QCCq NUm3bVdIUUN3ME2xJO69VQ>? M3KzZ|E4OTV5MEC5
U937 MoLuSpVv[3Srb36gRZN{[Xl? Mkj3OUDPxE1? M2fXelI1KGh? MkXnSG1UVw>? Mnq1TY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= Mkf4NVc1PDd5NUC=
U937 M3HNSGZ2dmO2aX;uJGF{e2G7 MlvkNUDPxE1? MmX3NlQhcA>? MVrEUXNQ NXLwTG9VTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> NFq0WYsyPzR2N{e1NC=>
RAW264.7 M2L0dmZ2dmO2aX;uJGF{e2G7 MU[xNEDPxE1? MmHMNlRp MXr3ZZRmeg>? MWXJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP M4m4blE4PDd5NUG4
RAW264.7 MlTFSpVv[3Srb36gRZN{[Xl? NInQdWsyOCEQvF2= NGjr[ZozPGh? NED5bIV4[XSnch?= MkD3TY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> NV\hZpdUOTd2N{e1NVg>
SC9 NELhTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDJOFghcA>? M1;id2lEPTB;MD62NFYh|ryP NYnEcoh6OTd3MEeyNVk>
ST14A M4e3bmZ2dmO2aX;uJGF{e2G7 NWKwZnVvPSCwTR?= NVjmRWt2PzJiaB?= MojyTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> M3jl[|E4PTZ3OUmz
ST14A NGexOJVHfW6ldHnvckBCe3OjeR?= M1rrNlUhdk1? NVXzRpF3PzJiaB?= NYnySm5kUW6lcnXhd4UhcW5iRULGNUBuWk6DIHX4dJJme3Orb36= MUWxO|U3PTl7Mx?=
PANC1 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\CT|Eh|ryP NX7De5NtUUN3ME2wMlQ2KM7:TR?= M4Tt[VE4PTh6N{S0
PANC1 NXzwbGh2TnWwY4Tpc44hSXO|YYm= MXexJO69VQ>? NXPlb3oxOjRiaB?= Mn\ETY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? NH:2fHMyPzV6OEe0OC=>
PANC1 NIjSfFdHfW6ldHnvckBCe3OjeR?= NF3IcFQyKM7:TR?= NX3aZpFwOjRiaB?= NFvHZopKdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> M17pW|E4PTh6N{S0
PT45 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHewOo9KSzVyPUSg{txO MW[xO|U5QDd2NB?=
ACHN MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\4fVIyKGh? MUHHTVUxRTBwNkWg{txO M3u1cFE4PjZ{NkC2
PC3 M3[1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvH[INLOjFiaB?= M330UGdKPTB;MD63NUDPxE1? M{X5[lE4PjZ{NkC2
A431 NYfqRYJsS3m2b4TvfIlkKEG|c3H5 MVe3NkBp NF\VTYRKSzVyPUSuNkDPxE1? NVvmUGNoOTd4OUG3OlM>
Cal27 MXvDfZRwfG:6aXOgRZN{[Xl? NITSXpY4OiCq M3ezWGlEPTB;Mz6yJO69VQ>? M2XlZVE4PjlzN{[z
CCRF-CEM MnvmR5l1d3SxeHnjJGF{e2G7 NHXSVWQ4OiCq NWDifIx2UUN3ME2wMlgh|ryP NX[xdpdvOTd4OUG3OlM>
EOL1 NWXCOZBzS3m2b4TvfIlkKEG|c3H5 MUS3NkBp MoXjTWM2OD1zIN88US=> MlfDNVc3QTF5NkO=
Hec-1-A MWrDfZRwfG:6aXOgRZN{[Xl? M{TnWFczKGh? MlXETWM2OD1zIN88US=> Mlj6NVc3QTF5NkO=
HeLa Mly2T4lv[XOnIFHzd4F6 MYCxNEDPxE1? M3fUUFMxKG2rbh?= M2TrUWROW09? NXjoU25yUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBJTEGFMTD3bZRpKEmFNUCgc4YhOC5yMjFOwG0> MWGxO|Y6OTd4Mx?=
RKOp21 NW\vRlVwS3m2b4TvfIlkKEG|c3H5 NHPLZmU4OiCq NFfJc3pKSzVyPUGuO|Yh|ryP M2X6SFE4PjlzN{[z
Saos2 NYGwcGRWS3m2b4TvfIlkKEG|c3H5 MmLCO|IhcA>? M{\5T2lEPTB;Mj6zJO69VQ>? NE\UdoIyPzZ7MUe2Ny=>
SK-OV-3 M1vuemN6fG:2b4jpZ{BCe3OjeR?= NH3JUXY4OiCq M1;DW2lEPTB;Mj6yJO69VQ>? MWOxO|Y6OTd4Mx?=
U87MG M{nFRmN6fG:2b4jpZ{BCe3OjeR?= NGn2bWs4OiCq M3PQd2lEPTB;MUGg{txO MVexO|Y6OTd4Mx?=
NUGC3 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe1JO69VQ>? M1\mR|I1KGh? M4K3TGdKPTB;Mj63PUDPxE1? NWP1XFJNOTd7MES4OFM>
CCD1059SK M3vOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHXRVhiUUN3ME20N{42KM7:TR?= M2XN[FE5OjR5NUW0
HepG2 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vOV2lEPTB;MD6wNFA3KM7:TR?= Ml\aNVgzPDd3NUS=
HT1080 NIf3eJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\RR2gxUUN3ME2wMlAxOjRizszN MnfRNVgzPDd3NUS=
SKBR3 NWW2fo03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwODFOwG0> NGjv[5UyQDJ2N{W1OC=>
SNB78 NFuxNGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTFR|UxRTF4IN88US=> M3jR[FE5OjR5NUW0
SQ20B NV;VZYdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe5NJhzUUN3ME2zJO69VQ>? M13GcVE5OjR5NUW0
St4 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6zRYVGSzVyPUWuNkDPxE1? MorXNVgzPDd3NUS=
MCF7 M3m5bGZ2dmO2aX;uJGF{e2G7 NX\ISmo6OTBizszN MVy4JIg> MorxSG1UVw>? Ml:3TY5lfWO2aX;uJI9nKHS3YoXsbY4hcHmyZYLhZ4V1gWyjdHnvci=> MYKxPFI3QTJ{Nh?=
HEK293 MlTnT4lv[XOnIFHzd4F6 MVmxJIg> NF\3NYtFVVOR M13HOGlvcGmkaYTpc44hd2ZiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNFMh|ryP MWKxPFMxQDV4Mx?=
HEK293 NET5PWtMcW6jc3WgRZN{[Xl? NGniVIsyKGh? NH3weXNFVVOR MXTJcohq[mm2aX;uJI9nKEiGQVOzJJdqfGhiSVO1NEBw\iByLkC1O{DPxE1? NXq0b4tUOTh|MEi1OlM>
G401 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PDW|czKGh? MlHzSG1UVw>? NV;uVGlKUUN3ME2xJO69VQ>? MYWxPFM4ODN5Mx?=
HeLa NF;PPW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO3NkBp M2C2NWROW09? M3\wbGlEPTB;MD60OkDPxE1? MoP2NVg{PzB|N{O=
Human renal epithelial cell M{P3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfWW4pmPzJiaB?= M33P[WROW09? Mn;sTWM2OD1zNDFOwG0> NWHoSm85OTh|N{CzO|M>
U937 Mn62SpVv[3Srb36gRZN{[Xl? MmnTOUDPxE1? NV7Z[2xwOjRiaB?= MYjJcoR2[3Srb36gc4YhcGm|dH;u[UBJPCCqeYDldoFk\XS7bHH0bY9v MWexPFM5OTJ|OB?=
U937 NH\TcpVHfW6ldHnvckBCe3OjeR?= M{fTb|Uh|ryP MmjYNlQhcA>? Ml3ZTY5lfWO2aX;uJI9nKGGucHjhJJR2[nWuaX6gbJlx\XKjY3X0fYxifGmxbh?= NG\CVo0yQDN6MUKzPC=>
U937 M{jRNmZ2dmO2aX;uJGF{e2G7 MorhOUDPxE1? NFrjTFUzPCCq M4e5[Wlv\HWldHnvckBw\iCyMkGg[ZhxemW|c3nvci=> NYDwSlU1OTh|OEGyN|g>
U937 M2X0SmZ2dmO2aX;uJGF{e2G7 MnLBOUDPxE1? MYSyOEBp MUnJcoR2[3Srb36gc4Yh[XCxcITvd4l{ NHLhN3gyQDN6MUKzPC=>
U937 NGO5eWRHfW6ldHnvckBCe3OjeR?= MmXaOUDPxE1? NVnxb5hHOjRiaB?= NHLhTJlKdmS3Y4Tpc44hd2ZiZ4LhcpVtd2O7dHnjJIRq\m[ncnXueIlifGmxbh?= MlzQNVg{QDF{M{i=
U937 M4fRd2tqdmG|ZTDBd5NigQ>? MUC1JO69VQ>? M4LpNFI1KGh? M3vXc2lvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{G= NFvpeokyQDN6MUKzPC=>
U937 Mm\YT4lv[XOnIFHzd4F6 NUHzeGxUPSEQvF2= NIXqUJAzPCCq NWXTfXBpUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDOC=> MXOxPFM5OTJ|OB?=
HEK-TE MofKSpVv[3Srb36gRZN{[Xl? NEfPc|M2KM7:TR?= MXW2bC=> MWTEUXNQ MlziTY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= MYexPFQ{PDF2NB?=
HPDE6c7 NG[zeXlEgXSxdH;4bYMhSXO|YYm= NWHLZ21XPTBizszN NFPTPJY4OiCq MVHEUXNQ NGrET2lKSzVyPUGuN{DPxE1? NYTGNGRIOTh2OUS0OlM>
Human microvascular epithelial cell NHvyelVEgXSxdH;4bYMhSXO|YYm= M3PCWlUxKM7:TR?= MYe3NkBp MXHEUXNQ NEezSJlKSzVyPUGuN{DPxE1? M4HvWlE5PDl2NE[z
Hup T3 NXTpO2JIS3m2b4TvfIlkKEG|c3H5 NHPDOFU2OCEQvF2= Mmr6O|Jp M1u1TmROW09? MXHJR|UxRTBwODFOwG0> NUjINZpiOTh2OUS0OlM>
Mia Paca2 NHzlWZREgXSxdH;4bYMhSXO|YYm= M{fmd|UxKM7:TR?= NXT1fYZuPzKq MVPEUXNQ NIHreY1KSzVyPUGuNUDPxE1? NXHpUIJSOTh2OUS0OlM>
Panc 04.03 M2jveWN6fG:2b4jpZ{BCe3OjeR?= M1foNlUxKM7:TR?= MljHO|Jp NIDUOFlFVVOR NX7ST2VoUUN3ME2xMlIh|ryP M4n0WlE5PDl2NE[z
SU 86.86 MVXDfZRwfG:6aXOgRZN{[Xl? M3\RbVUxKM7:TR?= MorTO|Jp NFnDdYJFVVOR MlS5TWM2OD1zLkOg{txO M1TYXFE5PDl2NE[z
HEK293 Mli2T4lv[XOnIFHzd4F6 M{PVdVMhcA>? M1XINWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgTGRCSzZiZYjwdoV{e2mxbjD3bZRpKEmFNUCgc4YhOC5yMUmg{txO M3j4e|E5PTV6Nk[5
HeLa NVf6OHRPU2mwYYPlJGF{e2G7 NW\rSohPOiCq NVHYW4lpUW6qaXLpeIlwdiCxZjDueYNt\WG{IFjERWMhf2m2aDDJR|UxKG:oIECuNFg{KM7:TR?= NUjWXVdjOTh3NUi2Olk>
RAW264.7 MkXWSpVv[3Srb36gRZN{[Xl? NUXz[mhuOiEQvF2= MXSzMlUhcA>? MknOSG1UVw>? NVexc2ptSW62aX3hcIFzcWGuIHHjeIl3cXS7IHHnZYlve3RiUHzhd41w\Gm3bTDmZYxkcXCjcoXtJIlv\mWldHXkJJdqfGhiSVO1NEBw\iByLkGxJO69VQ>? NX;kXWtvOTh4NES5Olk>
NB4 MmDLOFhp MonsSG1UVw>? M1jnS2lEPTB;MD62JO69VQ>? MVWxPFczOzN2OR?=
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T24 NF;2NHJMcW6jc3WgRZN{[Xl? NHK1cpQ{KGh? M2TVUWlv\HWldHnvckBw\iCjbIDoZUB1fWK3bHnuJIFk\XS7bHH0bY9vKHerdHigSWM2OCCxZjCwMlI2KM7:TR?= MkW0NVkxQDR|OUW=
HeLa NEPGRWNMcW6jc3WgRZN{[Xl? M{fySlE2KG2rbh?= MmPzSG1UVw>? M2D3RWlvcGmkaYTpc44hd2ZiSFTBR|Yh\nKxbTDueYNt\WG{IHX4eJJi[3Rid3n0bEBKSzVyIH;mJFAvODh3NTFOwG0> M3iyUFE6ODl|OEi0
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NCI-H69 NX:zN2Y4S3m2b4TvfIlkKEG|c3H5 MoHzO|IhcA>? Mn[wSG1UVw>? NFm3U4ZKSzVyPUKuNFYh|ryP MXexPVA6Ozh6NB?=
SKMES1 MnnuR5l1d3SxeHnjJGF{e2G7 M2LQfFczKGh? MWTEUXNQ M1LyNGlEPTB;Mj60NkDPxE1? M3\IdVE6ODl|OEi0
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SHSY5Y MljLT4lv[XOnIFHzd4F6 NXnrUo9POTBizszN MoPvOFghcA>? NXzOWHJuTE2VTx?= NF7kPYNKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOUDPxE1? MYCxPVM1PDF5NR?=
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DMS114 NXfwXGp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rXcFQ5KGh? MnXQS2k2OD1{Lkmg{txO MYKxPVQyQTJyNR?=
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SNB78 M4GzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXHRZE1QCCq NEi2VXBIUTVyPUG2JO69VQ>? M4fD[VE6PDF7MkC1
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BHK MnH1T4lv[XOnIFHzd4F6 MmLLOUDPxE1? M1rsUVI1KGh? NFjsTYlFVVOR M1:1dWlvcGmkaYTpc44hd2ZiSFTBR|ch\XiycnXzd4VlKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJBt[XOvYTDt[Y1jemGwZTDG[IVtfGF3MEigR2ZVWiCycn;0[Ylv MoDwNVk6PjZ5OEm=
CFBE41o- Mn7mT4lv[XOnIFHzd4F6 NHTnWnU2KM7:TR?= MUm4JIg> MkT5SG1UVw>? NYX2SWFWUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHj5dIVz[WOndInsZZRqd25ib3[gbIl{fG:wZTDINy=> NFPhZ4EyQTl4Nke4PS=>
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CFBE41o- M3\YbmtqdmG|ZTDBd5NigQ>? MYexJO69VQ>? MmrpNlQhcA>? M4j4[GROW09? MYDJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIF\k[Yx1[TVyODDDSnRTKHC{b4TlbY4hfHKjZn\pZ4tqdmd? NWH1eFZCOTl7Nk[3PFk>
CFBE41o- MWjLbY5ie2ViQYPzZZk> MVu1JO69VQ>? Mny2NlQhcA>? MUHEUXNQ NFLuR3BKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJJifGVib3[gcYF1fXKjdHnvckBw\iCFRmTSJJBzd3SnaX6geI8hcXS|IHfsfYNw\m:{bR?= NHmx[nIyQTl4Nke4PS=>
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Primary bronchial epithelial cell MXnLbY5ie2ViQYPzZZk> Ml;CNUDPxE1? NEXQN5E6PiCq MoDuSG1UVw>? MUHJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIPoc5J1KGOrcnP1bZQh[3W{cnXueJM> NUjjSnQ1OTl7Nk[3PFk>
BxPC3 M1\yXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fkZlczKGh? Mn;kTWM2OD1{Lkeg{txO MV[yNFE1Ozd5OB?=
CAL27 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[wO|IhcA>? Mk\DTWM2OD1|LkeyJO69VQ>? Ml24NlAyPDN5N{i=
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HCC827 M1LJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTm[nNWPzJiaB?= NFT6dlFKSzVyPUGuPEDPxE1? M4jFUlIxOTR|N{e4
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NCI-H2122 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWC3NkBp NYLmdXNVUUN3ME23MlUh|ryP NFro[ZUzODF2M{e3PC=>
NCI-H358 M{HER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXjeo4{PzJiaB?= MmK0TWM2OD1{LkWg{txO M365bVIxOTR|N{e4
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Caco-2 NV\3SnREU2mwYYPlJGF{e2G7 NXy2fJpSOC5|MU[gcm0hfG9iM{GuOkDPxE1? M4fT[FQhcA>? MYDEUXNQ MX7FfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzZ? MYqyNFE1Ozh2MB?=
HepG2 Mo\4T4lv[XOnIFHzd4F6 MlHzOUDPxE1? MkDFOog> MYXEUXNQ MYnJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u NHP0fZQzODF2M{i0NC=>
HepG2 NXfuVJlIU2mwYYPlJGF{e2G7 MXq1JO69VQ>? NHj0clg3cA>? MoT5SG1UVw>? NXOyPFFFUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u M{DjbFIxOTR|OESw
HepG2 NXXsTW9MU2mwYYPlJGF{e2G7 NEfSZoU2KM7:TR?= MVK2bC=> M4riSWROW09? MXPJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w NWTI[mM3OjBzNEO4OFA>
HepG2 NGD2UJRMcW6jc3WgRZN{[Xl? M3j5N|Uh|ryP M{DsRVZp NHToZoNFVVOR MorTTY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgTFMwUDRiaHnzeI9v\SCjY3X0fYxifGmxbh?= NXO4VoJoOjBzNEO4OFA>
COLO205 NGO1[WhMcW6jc3WgRZN{[Xl? NX[zXWxIOTBizszN MXKyOEBp MVHEUXNQ NVrrfXkzUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NELmSYwzODR3MUO3PC=>
SCC4 MXjLbY5ie2ViQYPzZZk> MVOxJO69VQ>? M4jjXFI1cA>? Mn\iTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= M3f0VlIxPDV{MkK1
SCC4 NUTySpR{U2mwYYPlJGF{e2G7 M3juVVEh|ryP M4H0flI1cA>? NWjKOWZUUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NEPKbG4zODR3MkKyOS=>
SCC4 MWPGeY5kfGmxbjDBd5NigQ>? NFPSNZIyKM7:TR?= NXHo[ndqPSCvaX6= MoHKRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= MWKyNFQ2OjJ{NR?=
NB4 MnW4SpVv[3Srb36gRZN{[Xl? NU\Qb2FsPSEQvF2= NXfEXmtCOjRiaB?= M1nvTWROW09? NE\iTXdE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl NYTRenF7OjB2OUG0OFA>
NB4 NXrwWHdpU2mwYYPlJGF{e2G7 NH\aXXg2KM7:TR?= MmHlNlQhcA>? Mo\kSG1UVw>? MYPJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPleJlt[XSnIIT1ZpVtcW5ibHX2[Yw> MVWyNFQ6OTR2MB?=
NB4 Ml[0SpVv[3Srb36gRZN{[Xl? M2rjXFUh|ryP M2\ZeVI1KGh? MYnEUXNQ MlK1TY5lfWO2aX;uJI9nKHB{MWfBSlEwS0mSMTDlfJBz\XO|aX;u NVnBT2tCOjB2OUG0OFA>
NB4 NH\xV5VMcW6jc3WgRZN{[Xl? MlXQOUDPxE1? NV30Too2OjRiaB?= MWrEUXNQ M3XJUmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v MYmyNFQ6OTR2MB?=
NUGC3 NIrLZnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rFSmdKPTB;Mj65OEDPxE1? M2fhVlIxQDVyOUex
A549 MXXGeY5kfGmxbjDBd5NigQ>? MVS1JO69VQ>? NFHqc4c{KGh? MUTEUXNQ M1ewWGlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> M1jmWVIxQDV3MkC4
HUT78 M1fGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU[3NkBp NVqxfm97TE2VTx?= NUW4WVU{T0l3ME2wMlMh|ryP MYOyNFg5PDJyOB?=
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A431 M4ni[GN6fG:2b4jpZ{BCe3OjeR?= MmjhO|IhcA>? NIrK[I5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= MV:yNVA5ODZ{OR?=
A549 MYXDfZRwfG:6aXOgRZN{[Xl? NEL3WJg4OiCq NHHhd25EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= NHXLeGszOTB6ME[yPS=>
CAL27 NVjFW|ZtS3m2b4TvfIlkKEG|c3H5 M3jWU|czKGh? MVvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP MUKyNVA5ODZ{OR?=
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Sf21 NH30UG5McW6jc3WgRZN{[Xl? M2\CZ|MhcA>? NU\WOVM3UW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> MkDzNlExQDB4Mkm=
SKBR3 MVfDfZRwfG:6aXOgRZN{[Xl? NYDkZVR7PzJiaB?= MmXsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= MmfNNlExQDB4Mkm=
SKOV3 NI\IOldEgXSxdH;4bYMhSXO|YYm= NY[ySZpKPzJiaB?= MXvDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP MoTzNlExQDB4Mkm=
COR-L23 M4flcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\HNVAh|ryP MYi3NkBp NWTZV|kyTE2VTx?= MUTHTVUxRTFwMTFOwG0> MnjTNlExQDB4NEe=
DU145 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmxNEDPxE1? MXS3NkBp M3rPTmROW09? MX7HTVUxRTFwMEWg{txO MkfONlExQDB4NEe=
LoVo M4jQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\hb3MyOCEQvF2= MWm3NkBp NFzR[3BFVVOR M3mzc2dKPTB;MT63JO69VQ>? M2WwSlIyODhyNkS3
MCR5-SV2 M4HrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVywemRZOTBizszN M4LTV|czKGh? MoHjSG1UVw>? M1TUbWdKPTB;Mj6xJO69VQ>? M4PqZ|IyODhyNkS3
HCT116 MVvLbY5ie2ViQYPzZZk> MXqzNEDPxE1? NXXTfGxlOzBiaB?= MX7EUXNQ Mo\4TY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NEn5fnQzOTB6ME[0Oy=>
HCT116 NWKzZVB{U2mwYYPlJGF{e2G7 MojNN|Ah|ryP NX;pZZJwOzBiaB?= M3Xy[2ROW09? Ml\QTY5pcWKrdHnvckBw\iCKRFHDNUBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gbIl{fG:wZTDIN2s6KGGlZYT5cIF1cW:w M3LTW|IyODhyNkS3
U937 NFHYO5dMcW6jc3WgRZN{[Xl? MYG1JO69VQ>? NWHzWZM2OjRiaB?= MXXEUXNQ MXHJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMQQ>? Mmq2NlEzQTJ2OUK=
U937 Mk\YT4lv[XOnIFHzd4F6 MXi1JO69VQ>? M3WxTVI1KGh? MY\EUXNQ NYXm[WFnUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 MYGyNVI6OjR7Mh?=
U937 MYfLbY5ie2ViQYPzZZk> MWS1JO69VQ>? Ml65NlQhcA>? NVnRXXlRTE2VTx?= M371fGlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu MWGyNVI6OjR7Mh?=
U937 MX3LbY5ie2ViQYPzZZk> NEHQbYQ2KM7:TR?= M3fmdFE2KG2rbh?= M4DnVWROW09? MW\Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiCuZY\lcC=> NEnadYkzOTJ7MkS5Ni=>
A2780 NYPBcXgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnTSpE6PiCq NEizd3JFVVOR MmrnTWM2OD1zLk[yJO69VQ>? NWLrRlR7OjF4M{S0N|A>
COLO205 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXqPVYhcA>? Mk\nSG1UVw>? MoTBTWM2OD1{LkGyJO69VQ>? NYDQSJVFOjF4M{S0N|A>
Hep3B MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYr3ZWtUPDhiaB?= NIjxUWhFVVOR MWnHTVUxRTFwMkGg{txO M3LBSlIyPzF{MUS2
GM11272 M4LzVWZ2dmO2aX;uJGF{e2G7 NWnwTYpuOTByIH7N MlXsO|IhcA>? NUKyWFExTE2VTx?= MX7S[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N Mnn6NlE5PDB5MU[=
CFBE41o NV;WcmxrU2mwYYPlJGF{e2G7 M2Lre|Uh|ryP NF7pd5RFVVOR MkjqSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO MVuyNVk5PDl3OB?=
CFBE41o NFP1elFHfW6ldHnvckBCe3OjeR?= M{Hxe|Eh|ryP NYPBfHljOjRiaB?= MWnEUXNQ MlH4VoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| M2[2cVIyQTh2OUW4
DU145 MWDLbY5ie2ViQYPzZZk> M2\UNVIvPSEQvF2= MkfQNlQhcA>? NWjsVo45TE2VTx?= M1znXmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> M2LvZ|IzOjZyMU[2
DU145 NHLibYxMcW6jc3WgRZN{[Xl? MoTQOUDPxE1? M1PMXFI1KGh? MXrEUXNQ NGfQTZBKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKNDDhZ4V1gWyjdHnvci=> M4TGelIzOjZyMU[2
DU145 NYjVeHRqU2mwYYPlJGF{e2G7 NUDESHdQPSEQvF2= MWSyOEBp M1Gx[mROW09? NWmyfI1HUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= MnLCNlIzPjBzNk[=
786-0 M4XZe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XaNlYvOiEQvF2= NWCyOIVTPzJiaB?= MYLEUXNQ MVTHTVUxRTNwMjFOwG0> NF\CeIMzOjR|NU[2PS=>
A498 M4jPWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3zOk4zKM7:TR?= NHnRUJk4OiCq Mom5SG1UVw>? NVjlRllQT0l3ME2xMlYh|ryP NYrSOFc{OjJ2M{W2Olk>
A549/ATCC M3HmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWC2MlIh|ryP NFfuWIw4OiCq NYPsfII3TE2VTx?= NWq1dZpTT0l3ME2xMlYh|ryP NYm3[4NmOjJ2M{W2Olk>
ACHN MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi0eII3NjJizszN M2fnOVczKGh? NUjmXXdZTE2VTx?= M2P2OmdKPTB;MT6zJO69VQ>? NHX3dJgzOjR|NU[2PS=>
BT549 NXPQe4pqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPCOk4zKM7:TR?= MkjoO|IhcA>? NED4PHdFVVOR MUnHTVUxRTFwMzFOwG0> NVzTPFVjOjJ2M{W2Olk>
EKVX MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLtZ|BVPi5{IN88US=> MnPSO|IhcA>? M1G0bmROW09? Mn3kS2k2OD1zLkOg{txO NX31VIZ6OjJ2M{W2Olk>
HCT15 NHrJcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3NOk4zKM7:TR?= M{f5WFczKGh? MYfEUXNQ MWTHTVUxRTJwNTFOwG0> NEjKS5UzOjR|NU[2PS=>
HOP92 NWD0do1XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjmOk4zKM7:TR?= M{LhcVczKGh? NHHjfVdFVVOR NHflcndIUTVyPUSg{txO NIrER2ozOjR|NU[2PS=>
IGROV1 NGDqNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\KOk4zKM7:TR?= MXy3NkBp MUnEUXNQ NHO3NFRIUTVyPUGuN{DPxE1? M2H0TVIzPDN3Nk[5
LOXIMVI NWTtV2lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33yXFYvOiEQvF2= MnLNO|IhcA>? MorjSG1UVw>? M4fKOGdKPTB;MTFOwG0> Ml\4NlI1OzV4Nkm=
M14 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTmVXE3NjJizszN NUPYbmxnPzJiaB?= MmPoSG1UVw>? NYPSdIhsT0l3ME2xMlMh|ryP NYHzUFMzOjJ2M{W2Olk>
MALME-3M MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;rU5Y3NjJizszN NWnnVpRHPzJiaB?= NGLl[2tFVVOR MnHMS2k2OD1yLkOyJO69VQ>? MonLNlI1OzV4Nkm=
MCF10A MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVW2MlIh|ryP MlzaOFghcA>? MkjnSG1UVw>? MYjHTVUxRTlwNjFOwG0> NYjLS2J5OjJ2M{W2Olk>
MDA-MB-435 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4G4dlYvOiEQvF2= NYezVYQ{PzJiaB?= MUnEUXNQ MnjWS2k2OD1yLkWg{txO M3XmU|IzPDN3Nk[5
MDA-MB-468 M{HhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7sUG5jPi5{IN88US=> NEW4Wok4OiCq MWnEUXNQ M3rZS2dKPTB;MD62N{DPxE1? MonvNlI1OzV4Nkm=
MOLT4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fKd|YvOiEQvF2= MXu3NkBp NIPDVVNFVVOR MYDHTVUxRTBwNDFOwG0> M3LueVIzPDN3Nk[5
NCI-ADR-RES NYHPSmlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYS2MlIh|ryP NYL3[WpoPzJiaB?= NGjYT2hFVVOR NVn5ZopwT0l3ME2wMlE3KM7:TR?= M2jLe|IzPDN3Nk[5
NCI-H23 NH61WW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXEOk4zKM7:TR?= Mn;GO|IhcA>? MnrrSG1UVw>? NHXmeI9IUTVyPUGg{txO M2\wTlIzPDN3Nk[5
NCI-H322M MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVO2MlIh|ryP MXO3NkBp NFHQRmpFVVOR NEPRPFlIUTVyPUCuO|kh|ryP MkfLNlI1OzV4Nkm=
NCI-H460 NVjMfWNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP4cIQ3NjJizszN MkH4O|IhcA>? MWPEUXNQ NHzXdpBIUTVyPUCuO|kh|ryP M33LcFIzPDN3Nk[5
NCI-H522 NIDDSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK5Ok4zKM7:TR?= M3ezZ|czKGh? Mn;rSG1UVw>? NEPXPI5IUTVyPUCuOUDPxE1? NX3HVWhzOjJ2M{W2Olk>
OVCAR3 NWDESo5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e1OlYvOiEQvF2= NX64Z3h{PzJiaB?= M{jIWmROW09? MkTJS2k2OD1zLkOg{txO MUSyNlQ{PTZ4OR?=
OVCAR4 MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW0bmg3NjJizszN M1PmXVczKGh? MmjrSG1UVw>? M2DoRWdKPTB;NDFOwG0> NXXqSXgzOjJ2M{W2Olk>
OVCAR5 NX3YcWZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXW2MlIh|ryP NF75N3k4OiCq M1[4T2ROW09? Mn;QS2k2OD1yLke5JO69VQ>? NF7BVIkzOjR|NU[2PS=>
OVCAR8 M{HQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHzOk4zKM7:TR?= NXPGflNXPzJiaB?= NHqxWYhFVVOR NInjZoNIUTVyPUCuOUDPxE1? M3v6bVIzPDN3Nk[5
RXF393 NXX0WXd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3WzXFYvOiEQvF2= MVK3NkBp MUXEUXNQ NV3HcHlmT0l3ME2xMlMh|ryP MX:yNlQ{PTZ4OR?=
SF268 NX;OToFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVe2MlIh|ryP NIm3dFc4OiCq MoL2SG1UVw>? NIXhVoRIUTVyPUGuOkDPxE1? MUWyNlQ{PTZ4OR?=
SF295 NUe0epR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi2MlIh|ryP NUf6UohrPzJiaB?= M3X0T2ROW09? MoXYS2k2OD1zLk[g{txO NXHDW4ZKOjJ2M{W2Olk>
SF539 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHHUpY3NjJizszN NWrV[2R[PzJiaB?= MnHPSG1UVw>? MYjHTVUxRTJizszN M4LCSlIzPDN3Nk[5
SK-MEL-2 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYS2MlIh|ryP NUn1OId1PzJiaB?= MYDEUXNQ NFSzdFBIUTVyPUGuN{DPxE1? MkC1NlI1OzV4Nkm=
SK-MEL-28 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYK2MlIh|ryP NIfHNXA4OiCq NHz5cVFFVVOR NVHRVlY4T0l3ME2xJO69VQ>? NWjCb45iOjJ2M{W2Olk>
SK-MEL-5 MmX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OwUlYvOiEQvF2= MoTlO|IhcA>? M4PubWROW09? M3nz[WdKPTB;MD62N{DPxE1? MXqyNlQ{PTZ4OR?=
SKOV3 M2rFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfLOk4zKM7:TR?= NIDGb4M4OiCq MoTvSG1UVw>? M{HZZ2dKPTB;MTFOwG0> NY\aeZVUOjJ2M{W2Olk>
SN12C MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;IS2c3NjJizszN MVS3NkBp NWrOXJN1TE2VTx?= M3zRWWdKPTB;MjFOwG0> M1Lye|IzPDN3Nk[5
SNB19 M1P0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj6Ok4zKM7:TR?= MlXXO|IhcA>? MUTEUXNQ MlW2S2k2OD1yLk[zJO69VQ>? M4DSOFIzPDN3Nk[5
SNB75 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYe2MlIh|ryP MnLZO|IhcA>? MVTEUXNQ Mn[3S2k2OD1yLke5JO69VQ>? MkXzNlI1OzV4Nkm=
SR NV;hTnRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWq2MlIh|ryP NGTFb5Y4OiCq NFXyOYNFVVOR MYjHTVUxRTBwNDFOwG0> NULLdlA5OjJ2M{W2Olk>
T47D NIXBVYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK5Ok4zKM7:TR?= MWO3NkBp M3\GfmROW09? MnS1S2k2OD1yLkWg{txO NFnjN3IzOjR|NU[2PS=>
TK10 NXS4S2FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLMOk4zKM7:TR?= NH\DZ2I4OiCq M2TofGROW09? NH\zNJJIUTVyPUCuOlMh|ryP NYe1[|ZYOjJ2M{W2Olk>
UACC257 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7QOk4zKM7:TR?= MojyO|IhcA>? NIP6fYNFVVOR M4PlS2dKPTB;MD61JO69VQ>? M4LKUlIzPDN3Nk[5
UACC62 NF7qTZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXq2MlIh|ryP NI\iRXI4OiCq NIfFXW1FVVOR M17rVmdKPTB;MD60JO69VQ>? NFXUfZAzOjR|NU[2PS=>
UO31 MkjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDnOk4zKM7:TR?= MlW3O|IhcA>? NGfUPZdFVVOR M4fQTGdKPTB;MD61JO69VQ>? Ml3XNlI1OzV4Nkm=
Hep3B MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[0PEBp MV3EUXNQ M2TCWmdKPTB;MD62PUDPxE1? MUSyNlQ{QTh4Mx?=
BE(2)-C MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDHNYpOPzJiaB?= NXLuZ21bTE2VTx?= MlfmTWM4OD1{IN88US=> NH3JXlYzOjl|MkOxOi=>
Bel7402 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLkdG04OiCq NE\2UmlFVVOR MVnHTVkxRTF5IN88US=> NXHVPVhKOjNyNkGzO|Y>
Bel7404 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmzNo9PPzJiaB?= MmTTSG1UVw>? MV;HTVkxRTF6IN88US=> NFntbpkzOzB4MUO3Oi=>
BGC823 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWe3NkBp Mnr0SG1UVw>? NFvUfI1IUTlyPUeuOUDPxE1? M4LZUFI{ODZzM{e2
MGC803 NUP4TZRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvrO|IhcA>? NWfVZYpyTE2VTx?= MY\HTVkxRTFyLkig{txO NYHDeJdFOjNyNkGzO|Y>
SGC7901 NFXVPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfjO|IhcA>? MVvEUXNQ NFPHW5ZIUTlyPUmuOEDPxE1? Mle3NlMxPjF|N{[=
SKHEP1 NVXnbowyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjNTWNHPzJiaB?= NH;6OHhFVVOR NXHlbWNJT0l7ME2xO{DPxE1? M1TjZlI{ODZzM{e2
SMMC7721 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCze|JmPzJiaB?= Mn7mSG1UVw>? MkK5S2k6OD1{MDFOwG0> NInIS2czOzB4MUO3Oi=>
NUGC3 Mln0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;KNVAh|ryP M4rGbGdKRTJwOUSg{txO NUmzRWU4OjNzNkOzN|I>
A2780 CisR NHS3[ZBMcW6jc3WgRZN{[Xl? M2fqcFE5KGh? NWDRdXBVUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M4fI[FI{OjV{NkCz
CAL27 sens NHfHUYZMcW6jc3WgRZN{[Xl? NYfROmg6OThiaB?= MYfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO MljrNlMzPTJ4MEO=
CAL27 CisR M2XPOmtqdmG|ZTDBd5NigQ>? NX\MNVN5OThiaB?= M1yyUWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NIjFUlUzOzJ3Mk[wNy=>
KYSE-510 CisR MVPLbY5ie2ViQYPzZZk> NYjEVm9lOThiaB?= NIjqdmxKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP NHrFOVIzOzJ3Mk[wNy=>
KYSE-510 sens NYLLVJNxU2mwYYPlJGF{e2G7 Mly2NVghcA>? MV3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> M4rn[FI{OjV{NkCz
MDA-MB-231 sens NYfxbphsU2mwYYPlJGF{e2G7 NIjXeWEyQCCq NYfmc2VtUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= NGXCdY8zOzJ3Mk[wNy=>
MDA-MB-231 CisR M2Dmc2tqdmG|ZTDBd5NigQ>? NWDLWWJjOThiaB?= NYG3TWJlUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= M2\3RlI{OjV{NkCz
ES2 NILyVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml:1OFghcA>? MUjEUXNQ NHfrU3ZKSzVyPUGyMlch|ryP NIO3[JQzOzR7M{S0PS=>
MDA-MB-231 MnjtT4lv[XOnIFHzd4F6 NH;oe2QyOCEQvF2= MmK2N|AhdWmw NWTxVHR2TE2VTx?= Ml;hTY5pcWKrdHnvckBw\iCKRFHDNoE> MXyyN|Q6OzR2OR?=
MDA-MB-231 MV\LbY5ie2ViQYPzZZk> MWOxJO69VQ>? NWn3e2U6OjRiaB?= MXTEUXNQ M37JSmlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= MV:yN|Q6OzR2OR?=
HS68 NIDINWNEgXSxdH;4bYMhSXO|YYm= NEPiOWQyOCEQvF2= NHjsdVU4OiCq MkX1SG1UVw>? MXHJR|UxRTRwNjFOwG0> MnXrNlM2PzB3NEK=
MEF NIHmVm1EgXSxdH;4bYMhSXO|YYm= M1e0WFExKM7:TR?= M3jNflczKGh? NV\FXFdKTE2VTx?= MkLNTWM2OD12LkSg{txO MYiyN|U4ODV2Mh?=
BGC823 NWHLW|FYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPEUXNQ MWTHTVUxRTNwMEmg{txO MX6yN|YxOTdyNh?=
High5 MUTLbY5ie2ViQYPzZZk> MYGyOEBp NV7VfmFnUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= NF;ndFQzOzZyMkWyNy=>
High5 Ml7BT4lv[XOnIFHzd4F6 NUjzOpl7OjRiaB?= MXrJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? MYSyN|YxOjV{Mx?=
High5 MoHYT4lv[XOnIFHzd4F6 NHr2V|YzPCCq MX\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? MoC5NlM3ODJ3MkO=
A549 M3jycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHQSFhiTE2VTx?= MmXYTWM2OD1zLkC3PUDPxE1? NHrYfnIzOzZ2NEKxNC=>
HCT116 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXEUXNQ NE\R[lBKSzVyPUCuO|U4KM7:TR?= MWiyN|Y1PDJzMB?=
K562 NV7yS3R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPNcXpITE2VTx?= NXnDWnJPUUN3ME2wMlY1PSEQvF2= Mle0NlM3PDR{MUC=
GBC-SD MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDrOUDPxE1? M4jhRlczKGh? NXT1eJJrTE2VTx?= MlfETWM2OD1zND64JO69VQ>? MW[yN|cxPzJ4MB?=
HGC27 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVq1JO69VQ>? NEXOW2Y4OiCq NIP6N2RFVVOR NFjSfY9KSzVyPUWuOEDPxE1? MWWyN|cxPzJ4MB?=
HL60 NUfpdnd3U2mwYYPlJGF{e2G7 MlXROUDPxE1? NELQT|AzPCCq NUnKSoRSTE2VTx?= MoLETY5pcWKrdHnvckBw\iCKRFHD MXmyN|cxPzJ4MB?=
Vero NYH2dXNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1y0ZVczKGh? MoLFSG1UVw>? MXLJR|UxRTBwOTFOwG0> MmDzNlM4QDZ2NUK=
NCI60 MmDrR5l1d3SxeHnjJGF{e2G7 NVXjS|BUPDhiaB?= M4n0PWROW09? NV[3O5dOT0l;MD61N{DPxE1? NVHSVoxEOjRyMUWzNlc>
SW620 NUHYdpFTS3m2b4TvfIlkKEG|c3H5 NIfPOXc1QCCq NU\SeIY3TE2VTx?= MmfpS2k:OC53NDFOwG0> NIXhfW4zPDBzNUOyOy=>
U251 NHnveYZEgXSxdH;4bYMhSXO|YYm= MYO0PEBp NW\CbFNkTE2VTx?= M4jrZmdKRTFwNUOg{txO NH\ic|MzPDBzNUOyOy=>
KM12 MnvkR5l1d3SxeHnjJGF{e2G7 NGHGbIs1QCCq NWfrU|NJTE2VTx?= NYD3epZET0l;MT64PEDPxE1? NF3Mb20zPDBzNUOyOy=>
Hs578T NYn3e|BqS3m2b4TvfIlkKEG|c3H5 NGH3ZnY1QCCq Ml;KSG1UVw>? M{D0VmdKRTRwOEOg{txO MnTVNlQxOTV|Mke=
MDA-MB-231 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfENXE1QCCq MYTJR|UxRTBwMU[g{txO NF\lUJIzPDB7NUCxOi=>
MCF7 NUDIbWpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjK[nQ1QCCq MYXHTV0xNjR3IN88US=> MnnvNlQyOTl3NUW=
MDA-MB-435 NFnDTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jqelQ5KGh? MVTHTV0xNjh6IN88US=> M173XlI1OTF7NUW1
AsPC1 M{n0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fN[VMxKM7:TR?= MV:0PEBp M1r2Z2ROW09? MljNTWM2OD1|Lk[2JO69VQ>? NXLjTlVYOjRzOEWzO|g>
Jurkat E6.1 MkjXT4lv[XOnIFHzd4F6 NEXPTpUzKGh? MX;EUXNQ M4W4SWlvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP NHnMVm0zPDJ4MUi2Ni=>
KG1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSzcJY1QCCq NHHYd4pKSzVyPUGuNVUh|ryP M2HCeFI1PTJ3MECz
HEL NHOyOXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH21U4g1QCCq NYT2fGN5TE2VTx?= M{nDXWlEPTB;MD60PUDPxE1? MXGyOFY6PDB3NR?=
HSC3 NVTDT3E4S3m2b4TvfIlkKEG|c3H5 NVrLWVA3OTJiaB?= NELJNVdFVVOR NETocFVKSzVyPUCuO|Eh|ryP Mn;uNlQ4PjZ3NkC=
HT-29 NFLqdIZEgXSxdH;4bYMhSXO|YYm= M3O1XVEzKGh? M3jGemROW09? M3TNTWlEPTB;MD63NkDPxE1? MXSyOFc3PjV4MB?=
KB MmLuR5l1d3SxeHnjJGF{e2G7 NHLGbVQyOiCq M1rQdWROW09? M4LTNmlEPTB;MD63OUDPxE1? MofkNlQ4PjZ3NkC=
H460 MkPJR5l1d3SxeHnjJGF{e2G7 MojzNVIhcA>? MmnTSG1UVw>? NYjobGxQUUN3ME2wMlgzKM7:TR?= M{D2[FI1PzZ4NU[w
MONE1 MV7DfZRwfG:6aXOgRZN{[Xl? NEHi[m0yOiCq MVTEUXNQ M4[3bWlEPTB;MT6xPEDPxE1? MUGyOFc3PjV4MB?=
MKN45 MkP5R5l1d3SxeHnjJGF{e2G7 NVXmUWR[OTJiaB?= MV\EUXNQ M3zOW2lEPTB;MT6yOUDPxE1? NXSw[4lwOjR5Nk[1OlA>
TSGH MmXBR5l1d3SxeHnjJGF{e2G7 M1flO|EzKGh? NV:4PYRPTE2VTx?= M1rJ[2lEPTB;Mj6wPUDPxE1? M{jWeFI1PzZ4NU[w
HL60 M2rzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfrXIF1PzJiaB?= NILZeY1FVVOR Ml22S2k2OD1yLkmzJO69VQ>? NHnX[48zPDlyMEWwNC=>
HEK293 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\HSFczKGh? NVn2OGsxTE2VTx?= M1nUUGdKPTB;MUOg{txO NXXKPWgxOjR7MEC1NFA>
Jurkat M{\LO2N6fG:2b4jpZ{BCe3OjeR?= NFvDV48yODBizszN MUW3NkBp MVPHTVUxRTBwOTFOwG0> NIHMOW0zPDlyMEe0Ny=>
GM15850 M1LvVWtqdmG|ZTDBd5NigQ>? M2G1[VIvPSEQvF2= NXH1SVhuQTZiaB?= Ml3VSG1UVw>? Mmn0[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NIG2[ogyPjl{MUO2Oy=>
GM15850 M1vJfGtqdmG|ZTDBd5NigQ>? NVvKVHB5Oi53IN88US=> MV65OkBp MlPuSG1UVw>? M1XhbYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXTJU2VCOTZ7MkGzOlc>
GM15850 M4nCVmtqdmG|ZTDBd5NigQ>? NFz1bWQzNjVizszN NWS3Zpo{QTZiaB?= NWrZNnp5TE2VTx?= M37V[IRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyOiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NGP4ZYoyPjl{MUO2Oy=>
GM15850 NGPGRmVMcW6jc3WgRZN{[Xl? MlXFNk42KM7:TR?= NFHTOJE6PiCq MmCySG1UVw>? M1:zeIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MWixOlkzOTN4Nx?=
GM15850 M{XLVGtqdmG|ZTDBd5NigQ>? MUiyMlUh|ryP MV65OkBp NIrI[YVFVVOR M1jIWoRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA5KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M2rsc|E3QTJzM{[3
GM15850 M1rLNGtqdmG|ZTDBd5NigQ>? M3\iW|IvPSEQvF2= NUnZfo13QTZiaB?= NXu4TJZzTE2VTx?= NGHQfW5ld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTZiYXPleJlt[XSrb36gc4YhTliQIHflcoU> M17zRlE3QTJzM{[3
GM15850 NYrqcmlsTnWwY4Tpc44hSXO|YYm= MVy1JO69VQ>? Mon4NVIhcA>? MYPEUXNQ M2HpfYhieyCwbzDl[oZm[3Rib36gSnhPKG2UTlGg[ZhxemW|c3nvci=> Mn;MNVY6OjF|Nke=
U937 MkG1T4lv[XOnIFHzd4F6 MUG1JO69VQ>? MUiyOEBp MUfEUXNQ NF;zZ|Bp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MYixO|Q1Pzd3MB?=
U937 M4jVRWtqdmG|ZTDBd5NigQ>? MmDVNUDPxE1? MYmyOEBp NXLHRW8yTE2VTx?= Ml7ObIF{KG6xIHXm[oVkfCCxbjDhcJBp[SC2dXL1cIlvKGGlZYT5cIF1cW:w NWLHdlRqOTd2NEe3OVA>
PANC1 M{fQUmZ2dmO2aX;uJGF{e2G7 NE\pSpQyKM7:TR?= NFPDbVIzPCCq MY\kc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= NYLp[ohGOTd3OEi3OFQ>
PANC1 MnnISpVv[3Srb36gRZN{[Xl? M1rQb|Eh|ryP NWq5WXFGPDhiIHi= MkDs[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= NX\OcoNCOTd3OEi3OFQ>
Caco-2 M3rtNWZ2dmO2aX;uJGF{e2G7 NV;ZT5VQPSEQvF2= M2\teVI1KGh? NV7NXHdXTE2VTx?= NIG0PIJld2W|IH7veEBqdmS3Y3WgVFIyX0GIMTDn[Y5mKGW6cILld5Nqd25? MVWyNFE1Ozh2MB?=
SCC4 NIDTWIpHfW6ldHnvckBCe3OjeR?= MVuxJO69VQ>? NHXiRmQyOCCvaX6= MXHEUXNQ MV7oZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? M4fOblIxPDV{MkK1
A549 NEPROVVHfW6ldHnvckBCe3OjeR?= MVK1JO69VQ>? NE\MVI4{KGh? M1rsTWROW09? NXPKUpc1\G:nczDuc5QhcW6mdXPlJIF2fG:yaHHnfUBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|NKUQ>? MlziNlA5PTV{MEi=
HCT116 Ml63T4lv[XOnIFHzd4F6 NGWyTJoxNjNizszN NW\wfos1OzBiaB?= MVvEUXNQ NG[2dYJld2W|IH7veEBqdmirYnn0JGhFSUNzIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCqaYP0c45mKEh|S{mgZYNmfHmuYYTpc44> NYLxdZp4OjFyOEC2OFc>
HepG2 NXLEfWMxTnWwY4Tpc44hSXO|YYm= MmXRNVAh|ryP NG\Jc2QzPCCq NXnmfnNyTE2VTx?= MYHkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m|IHHzd4V{e2WmIHHzJIh6eGW{YXPleJlt[XSrb36gc4YheDV| NGLh[2QzOTV2OEW4Ni=>
GM11272 MYHGeY5kfGmxbjDBd5NigQ>? MUOwMlEh|ryP NUj5R2tyPzJiaB?= MVzEUXNQ NXu5Um4{\G:nczDuc5QhemWjY4TpeoF1\SCPZVPwNkBufXSjboSg[ZhxemW|c3nvci=> MmW5NlE5PDB5MU[=
MDA-MB-231 NH34[ZZMcW6jc3WgRZN{[Xl? MV[xNEDPxE1? MWW1JI1qdg>? NH71UFZFVVOR M3XBWoRw\XNibn;0JIlvcGmkaYSgTGRCSzKj MUiyN|Q6OzR2OR?=
MDA-MB-231 NFXPPXpMcW6jc3WgRZN{[Xl? NV3meYpPOSEQvF2= NFfZSokzPCCq Ml;JSG1UVw>? MmfY[I9meyCwb4SgbY5pcWKrdDDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NGjrW4MzOzR7M{S0PS=>
K562 NWGwfph3U2mwYYPlJGF{e2G7 M2Dhe4Rw\XNibn;0JIlvcGmkaYSgTGRCSw>? MU[yN|U6OTFzMR?=
Jurkat M4nNN2N6fG:2b4jpZ{BCe3OjeR?= NFjlSpYzOCEQvF2= NHG2O5c4OiCq MUTEUXNQ NF\GWHZvdyCleYTveI95cWOrdImgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44> NH3henczPDNyNEO0PC=>
HCT116 NHvpO2pCeG:ydH;zbZMhSXO|YYm= Mlj0N{DPxE1? M4PHfFI1KGh? NGHXXY5FVVOR NXLWXZlX\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOVMheHKxdHXpckBt\X[nbB?= MkntNlQ4PjZ3NkC=
KASUMI-1 NF2yNnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTl7LkG3JI5O NF7leG5USU6JRWK=
KARPAS-45 NEXCWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rveGlEPTB;MUezMlg6KG6P MYHTRW5ITVJ?
BHT-101 NF3GTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTXXYx4UUN3ME2yOFQvOThibl2= NXTIUI1XW0GQR1XS
H9 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DjdWlEPTB;MkW1MlA1KG6P NVPITWl6W0GQR1XS
PA-1 M4H2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXaTWM2OD1{OE[uNlYhdk1? NUix[XFTW0GQR1XS
NEC8 NF\4[3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfaTWM2OD1{OEmuN|ghdk1? MlHuV2FPT0WU
MHH-PREB-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:5TWM2OD1{OUSuOVMhdk1? NGXMTYNUSU6JRWK=
NB7 Ml;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXJTWM2OD1|NEWuO|Qhdk1? NIK4e5RUSU6JRWK=
A3-KAW MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz2SJlmUUN3ME20NFAvPTlibl2= M3LqVXNCVkeHUh?=
NB69 M1ryRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3NUnhKSzVyPUSxNU44OSCwTR?= MV\TRW5ITVJ?
EoL-1-cell NGewbYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTR3NEK1JI5O NWjuW5k3W0GQR1XS
CHP-212 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX6ZWpPUUN3ME20OVcvPTNibl2= NVPGZYhEW0GQR1XS
C2BBe1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jleWlEPTB;NEeyMlE6KG6P NY\lTFFSW0GQR1XS
697 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGmzSnZKSzVyPUS3N{41OSCwTR?= MnHkV2FPT0WU
BCPAP NYTwV|htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPHTWM2OD13MEGuOFIhdk1? NWDkXpRFW0GQR1XS
L-363 M33Iemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13ER2lEPTB;NUCzMlEhdk1? M2rZbHNCVkeHUh?=
ES8 NHrXXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXVTWM2OD13MkOuOVMhdk1? NYfPfYV1W0GQR1XS
BE-13 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmzTWM2OD13Mk[uPVYhdk1? M2Tmb3NCVkeHUh?=
CTB-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfXTWM2OD13M{euPVIhdk1? NFO4c|ZUSU6JRWK=
HD-MY-Z NHnKdlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTV|OD6xN{BvVQ>? NXfE[5g3W0GQR1XS
NKM-1 M4O0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\xU|BKSzVyPUW0OE4zPyCwTR?= NGm1TlFUSU6JRWK=
NCI-H720 M2HSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXKcXlKSzVyPUW2NE4yQCCwTR?= MVnTRW5ITVJ?
KY821 NFHtcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPBTWM2OD13NkOuNlUhdk1? MlX3V2FPT0WU
OVCAR-5 NEXpc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\jTWM2OD13N{[uNVEhdk1? MUjTRW5ITVJ?
CTV-1 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\KUYFKSzVyPUW4NU42PiCwTR?= M3PJcHNCVkeHUh?=
P12-ICHIKAWA MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\RPWlEPTB;NUm2MlUyKG6P M4jXdHNCVkeHUh?=
DB MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjRW3FKSzVyPUW5PE42PyCwTR?= NWTPeJk5W0GQR1XS
CHL-1 NIjtTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjKSHFKSzVyPU[0Nk4xQCCwTR?= NYX5U2ZlW0GQR1XS
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HL-60 NEfORlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj0TWM2OD1zLkmzPVAzKM7:TR?= NYrxcXdKW0GQR1XS
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LB2241-RCC MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe2UmI3UUN3ME2xMlk5OjNzIN88US=> NFTNcIdUSU6JRWK=
Ramos-2G6-4C10 M3rYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnNbZdoUUN3ME2xMlk6PDl|IN88US=> NUXLRpdNW0GQR1XS
A101D NHfyOIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwMkCzNFMh|ryP NHTZe5ZUSU6JRWK=
NCI-H446 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWzVpV7UUN3ME2yMlA1PTl7IN88US=> NVzCb2o3W0GQR1XS
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LCLC-97TM1 M3XGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJwMUS1PFMh|ryP MX;TRW5ITVJ?
DMS-273 M{XaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJwMUS4N|ch|ryP MmLqV2FPT0WU
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IST-SL1 M3;G[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJwMU[4OFQh|ryP M{D1eHNCVkeHUh?=
GCT MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7hZ29KSzVyPUKuNVc4PyEQvF2= NHX4SFFUSU6JRWK=
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CAL-39 M2\NXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzTTWM2OD1{LkKzOlI3KM7:TR?= M4PrcnNCVkeHUh?=
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NCI-H1666 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DXVmlEPTB;Mj6yPFEyOSEQvF2= MWjTRW5ITVJ?
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8-MG-BA Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\CSWJQUUN3ME2yMlM{QTB4IN88US=> MkPaV2FPT0WU
RH-18 M{jQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXacJJKSzVyPUKuN|UxOjJizszN MYjTRW5ITVJ?
NCI-H1155 NV33ZpV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLRb2wzUUN3ME2yMlM3PzJ3IN88US=> MVrTRW5ITVJ?
NB17 NUHyXVE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPwNXlrUUN3ME2yMlM5OjR|IN88US=> NU[2UGZsW0GQR1XS
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HSC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwNES1NFkh|ryP MkTrV2FPT0WU
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HT-3 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwNEm1N|Uh|ryP MoTzV2FPT0WU
NCI-H2170 NYnNTJRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHJUWo1UUN3ME2yMlUxPTR7IN88US=> NWXvWFlnW0GQR1XS
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KU-19-19 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXm1WGRwUUN3ME2yMlU{PTF|IN88US=> NYjGV|l6W0GQR1XS
NCI-H1048 NGXpe3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fJdWlEPTB;Mj61OVAzPSEQvF2= MV7TRW5ITVJ?
KOSC-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojQTWM2OD1{LkW2NFc3KM7:TR?= MlPXV2FPT0WU
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NCI-H2126 MoHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJwNkC5PFQh|ryP M{ToTXNCVkeHUh?=
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NCI-H661 NVfnNJpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXm3eldzUUN3ME2yMlY1ODh3IN88US=> MoTYV2FPT0WU
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BPH-1 M2HtWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrrPIJKSzVyPUKuOlU5PSEQvF2= M{Da[3NCVkeHUh?=
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NB12 MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTJwN{G3NUDPxE1? NHH1XnpUSU6JRWK=
SK-HEP-1 NYS5TFU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13udGlEPTB;Mj63OFM6OSEQvF2= MmPkV2FPT0WU
U-266 M{HpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJwN{exNlEh|ryP M4nWc3NCVkeHUh?=
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PC-14 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwOEC1NUDPxE1? M2LlUnNCVkeHUh?=
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LCLC-103H Mn3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJwOUC0N|gh|ryP MUDTRW5ITVJ?
SW1573 Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\TTWM2OD1{Lkm2NFgzKM7:TR?= MnrjV2FPT0WU
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RMG-I MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXSVXFKSzVyPUOuNFI2QTJizszN MUPTRW5ITVJ?
BB65-RCC MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVKyU|ZQUUN3ME2zMlA{OzF2IN88US=> M3vYe3NCVkeHUh?=
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SF268 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwMES1NlMh|ryP NHrmW4pUSU6JRWK=
NCI-H810 M1T5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTNwMES4NlMh|ryP M2rnVnNCVkeHUh?=
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SW13 NIixR|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrEeGVJUUN3ME2zMlA4QDR5IN88US=> MY\TRW5ITVJ?
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GT3TKB NH[1cmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDUTWM2OD1|LkGxNlg{KM7:TR?= NHLn[VFUSU6JRWK=
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T-24 NV22NnVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LPZmlEPTB;Mz6xOVA4KM7:TR?= MYnTRW5ITVJ?
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GR-ST Mnn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ZW5FXUUN3ME2zMlIzOTN7IN88US=> NFjTSmFUSU6JRWK=
LB2518-MEL M3PN[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNwMkKzPVgh|ryP MULTRW5ITVJ?
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NCI-H1651 NIrSfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXIWY5WUUN3ME2zMlI1PjR2IN88US=> NX\nZXBDW0GQR1XS
EC-GI-10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP0PINKSzVyPUOuNlYyPTNizszN NWTOV3RFW0GQR1XS
HT-29 M3HOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwMk[2NVQh|ryP MlLvV2FPT0WU
GI-ME-N NXnGXI1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrIeWc6UUN3ME2zMlI6PTFzIN88US=> NECwWFhUSU6JRWK=
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NCI-H1563 NYDJWohQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6wXGtKSzVyPUOuN|MxOThizszN M2fRS3NCVkeHUh?=
DJM-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DMN2lEPTB;Mz6zO|Y4PCEQvF2= M3PXSnNCVkeHUh?=
L-428 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrROmlKSzVyPUOuOFAxPDVizszN NIPHXW1USU6JRWK=
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CAL-12T M4\2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\s[5VKSzVyPUSuNVMyODNizszN NWnaUoIzW0GQR1XS
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CAL-33 NVHVSWJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\GUJZRUUN3ME20MlI{ODZ2IN88US=> MlHVV2FPT0WU
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KYSE-70 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33Ie2lEPTB;ND6yPVM1KM7:TR?= M4i3S3NCVkeHUh?=
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KYSE-270 M3\Xd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPYTWM2OD13Lk[2NFMyKM7:TR?= Mk\MV2FPT0WU
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COLO-678 NVr2VHR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1npOGlEPTB;MkeuOFkyQSEQvF2= MoTWV2FPT0WU
KURAMOCHI NUjoOnpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPaUIlKSzVyPUK4MlEzPiEQvF2= NYLITVh[W0GQR1XS
NCI-H1650 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrGUlRKSzVyPUOwMlE6OjRizszN NEnndnNUSU6JRWK=
HCC1954 M2WydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmCzTWM2OD1|MT6zOlY3KM7:TR?= NHHGdIJUSU6JRWK=
GAK Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLlXWRTUUN3ME2zNk4zPjF4IN88US=> MV7TRW5ITVJ?
YAPC MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPrTWM2OD1|Mz63OlQ5KM7:TR?= M4LtSnNCVkeHUh?=
NCI-H2228 MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTN2LkO2NFUh|ryP MXnTRW5ITVJ?
VMRC-RCZ MlO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3WxVmlEPTB;M{[uN|AzOiEQvF2= MmDnV2FPT0WU
NMC-G1 M3PuTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;LPI5XUUN3ME2zO{4xPTJ7IN88US=> M3nvU3NCVkeHUh?=
D-336MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjtTWM2OD12MT64OFQzKM7:TR?= NV7LT|NzW0GQR1XS
UACC-62 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe5N|RKSzVyPUSyMlU2ODVizszN M17XVHNCVkeHUh?=
C-33-A MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfoTWM2OD12NT6zNlU3KM7:TR?= NHTvO|ZUSU6JRWK=
HCC1937 M2rISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e1NmlEPTB;NEeuNVk2QCEQvF2= NXrEeWxKW0GQR1XS
HDLM-2 NHu4SIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLnVYoxUUN3ME20O{4zOjh5IN88US=> MWLTRW5ITVJ?
NCI-H727 NGTRWnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzuTWM2OD12Nz6yOFUyKM7:TR?= NFq5UZlUSU6JRWK=
NY NFexd21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTR7LkO5NFgh|ryP MX;TRW5ITVJ?
NCI-H2291 NW\DdmF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zNUWlEPTB;NEmuPFMxOSEQvF2= M3jrNXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Water Insoluble
Ethanol '3 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms MK0683
Smiles ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Withdrawn Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID