Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 Mn7QT4lv[XOnIFHzd4F6 M1rENVEhcA>? M1nNUWROW09? Mm\LZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP MnzlNVE6PjB2OEm=
Friend leukemic cell MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XQbFUxKM7:TR?= MmSxO|IhcA>? MV7EUXNQ M1LiWGlEPTB;MD65PUDPxE1? MYqxNlExQTlzMx?=
K562 NYG1ZYk6U2mwYYPlJGF{e2G7 M4S3eFYhcA>? MofzSG1UVw>? NHHhW|FKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> NX75b2VzOTJ2MUmzPFA>
HT1080 NXzo[WRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\wVVczKGh? M3jISmROW09? MkfOTWM2OD1{LkSg{txO MoPPNVIzPzBzN{W=
H1299 M37DfGtqdmG|ZTDBd5NigQ>? NIPy[mkzOCCvaX6= MXvEUXNQ NETvclZKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> NGrkUlEyPDV{MUSyNi=>
H1299 NGjYS2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PCN|czKGh? NWf6dWl5TE2VTx?= M4TMfmlEPTB;Nz6yOEDPxE1? MlT0NVQ2OjF2MkK=
HeLa MkC0T4lv[XOnIFHzd4F6 NUXFenEzOzBibXnu NWTLT4lIUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? MnzPNVU3ODN7NEm=
LOX-IMVI MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUixOmM5PDhiaB?= MYPJR|UxRTFwMzFOwG0> NXPVc41xOTV5MUW0O|A>
NCI-H226 MkDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\0[|Q5KGh? M2O3fGlEPTB;Mj62JO69VQ>? NWDMe|NvOTV5MUW0O|A>
RXF-631L MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\TZYs1QCCq NEjY[GtKSzVyPUKg{txO MXyxOVcyPTR5MB?=
SNB-78 M1jjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlizOFghcA>? MmTHTWM2OD1zNjFOwG0> MVOxOVcyPTR5MB?=
St-4 M1y2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TZUlQ5KGh? NGLOXXBKSzVyPUWuNkDPxE1? NYX1fYVnOTV5MUW0O|A>
ARP1 M3rl[GZ2dmO2aX;uJGF{e2G7 NIO2O3kzKM7:TR?= M2fqVVYhcA>? MWDJcoR2[3Srb36gc4YhWDJzV1HGNUBo\W6nIHX4dJJme3Orb36= MYKxOFc{PDhyNh?=
CEM NGPjNFZMcW6jc3WgRZN{[Xl? MYexJIg> NXvRZ2pyTE2VTx?= NXztbndyUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= NHvYZpoyPjR{MEC2OC=>
HCT15 M1;ITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\DS3E1QCCq M3\WTWdKPTB;MD64NkDPxE1? M{DVRlE3PzJ|MkK3
NCI-H23 MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUe0PEBp MWjHTVUxRTBwOUKg{txO M{C3NFE3PzJ|MkK3
GM15850 M1freGtqdmG|ZTDBd5NigQ>? M2H6TFIvPSEQvF2= NIXZW2w6PiCq NYTz[HJoTE2VTx?= M4eyXGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M2e2ZVE3QTJzM{[3
GM15850 NVrh[oZIU2mwYYPlJGF{e2G7 M32xWFIvPSEQvF2= NULQZ5duQTZiaB?= NIXsTWpFVVOR NFrTWplKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M4H0[FE3QTJzM{[3
GM15850 M{[zeGtqdmG|ZTDBd5NigQ>? MVSyMlUh|ryP NX7GcY05QTZiaB?= MkLZSG1UVw>? NGOxNndKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWD5[odvOTZ7MkGzOlc>
GM15850 NVG3fYNVU2mwYYPlJGF{e2G7 M1PwPFIvPSEQvF2= NEi3NI06PiCq MY\EUXNQ Mor6TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MXixOlkzOTN4Nx?=
GM15850 NHvVO29McW6jc3WgRZN{[Xl? MoLKNk42KM7:TR?= MlzzPVYhcA>? MoH4SG1UVw>? NWiyelNjUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M3HSNlE3QTJzM{[3
GM15850 MUfLbY5ie2ViQYPzZZk> NX3FPWR{Oi53IN88US=> NWDWboxEQTZiaB?= NG\qNWdFVVOR NUXSTYFnUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MnPmNVY6OjF|Nke=
U937 M4nHdmZ2dmO2aX;uJGF{e2G7 MnnlOUDPxE1? NW\jZWs{OjRiaB?= M17nXmROW09? NXrDdnRtS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= M4[1fVE4ODB2N{G4
H661 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTHSmR{PDhiaB?= MXLJR|UxRTFizszN MkHGNVcyPTdyMEm=
U937 M37aOmZ2dmO2aX;uJGF{e2G7 M1[yTlUh|ryP MY[yOEBp NVXLfI1uTE2VTx?= M123NGlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NGDDPVcyPzR2N{e1NC=>
U937 MUXGeY5kfGmxbjDBd5NigQ>? NFuxSIQyKM7:TR?= NXX5UJFqOjRiaB?= NFrYRlRFVVOR M{fUV2Vn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u MWGxO|Q1Pzd3MB?=
RAW264.7 MUPGeY5kfGmxbjDBd5NigQ>? NFnvVIwyOCEQvF2= M3GyXlI1cA>? MYL3ZZRmeg>? NIKxNVJKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NFTBSIcyPzR5N{WxPC=>
RAW264.7 MWLGeY5kfGmxbjDBd5NigQ>? NWjCb2JROTBizszN M{PQb|I1cA>? NEL5O|Z4[XSnch?= MmH2TY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> MnvSNVc1Pzd3MUi=
SC9 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DoR|Q5KGh? MoS5TWM2OD1yLk[wOkDPxE1? MUixO|UxPzJzOR?=
ST14A NWnJNI5zTnWwY4Tpc44hSXO|YYm= M1TJdFUhdk1? MXO3NkBp M2rvWGlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> M{PtSlE4PTZ3OUmz
ST14A Mn\3SpVv[3Srb36gRZN{[Xl? Mnq5OUBvVQ>? M1K2RVczKGh? MW\JcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? NWXFNVFTOTd3NkW5PVM>
PANC1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXixJO69VQ>? NELqNHRKSzVyPUCuOFUh|ryP NIrKOmQyPzV6OEe0OC=>
PANC1 MX;GeY5kfGmxbjDBd5NigQ>? MV2xJO69VQ>? MlL5NlQhcA>? MonqTY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? NEPoWGIyPzV6OEe0OC=>
PANC1 MYHGeY5kfGmxbjDBd5NigQ>? NWS1cWd{OSEQvF2= M4jpTVI1KGh? NGjnfHhKdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> NYDWVmRyOTd3OEi3OFQ>
PT45 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1WxTWlEPTB;NDFOwG0> MXWxO|U5QDd2NB?=
ACHN NXu0[JdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfQNlEhcA>? M1fMPGdKPTB;MD62OUDPxE1? NFXZVmMyPzZ4Mk[wOi=>
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HepG2 M2[5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\XTWM2OD1yLkCwNFYh|ryP MVixPFI1PzV3NB?=
HT1080 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETNWIVKSzVyPUCuNFAzPCEQvF2= NXrESFBbOTh{NEe1OVQ>
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SNB78 NFXT[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7FR|UxRTF4IN88US=> Ml\4NVgzPDd3NUS=
SQ20B MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH0TWM2OD1|IN88US=> M16yeFE5OjR5NUW0
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HEK293 M37oRmtqdmG|ZTDBd5NigQ>? M1XjPFEhcA>? NHvCfHJFVVOR MnfVTY5pcWKrdHnvckBw\iCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6wN{DPxE1? NEP0eVgyQDNyOEW2Ny=>
HEK293 NEjMR4xMcW6jc3WgRZN{[Xl? NUfyZ4tTOSCq M4HlSmROW09? Mm\VTY5pcWKrdHnvckBw\iCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6wOVch|ryP MXqxPFMxQDV4Mx?=
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Human renal epithelial cell MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XkfVczKGh? MYXEUXNQ M4LsNmlEPTB;MUSg{txO Mo\UNVg{PzB|N{O=
U937 M13F[WZ2dmO2aX;uJGF{e2G7 MmD3OUDPxE1? NIXuTZUzPCCq M1XDVWlv\HWldHnvckBw\iCqaYP0c45mKEh2IHj5dIVz[WOndInsZZRqd25? NYDTfIVJOTh|OEGyN|g>
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U937 NHrz[mxHfW6ldHnvckBCe3OjeR?= M3jKcFUh|ryP M{LGRlI1KGh? NH7PVoZKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M{TZO|E5OzhzMkO4
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U937 Ml7KT4lv[XOnIFHzd4F6 M1HGNlUh|ryP M3;hN|I1KGh? MWrJcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN2 M4\vSlE5OzhzMkO4
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Human microvascular epithelial cell NHP5[3VEgXSxdH;4bYMhSXO|YYm= NVvRN4RmPTBizszN MVW3NkBp MmnZSG1UVw>? MljJTWM2OD1zLkOg{txO NGj0SVEyQDR7NES2Ny=>
Hup T3 M1fJSWN6fG:2b4jpZ{BCe3OjeR?= MnG3OVAh|ryP M1X0TVczcA>? M3LyemROW09? MnjPTWM2OD1yLkig{txO NGLHUI4yQDR7NES2Ny=>
Mia Paca2 M2fYW2N6fG:2b4jpZ{BCe3OjeR?= NHzQbIg2OCEQvF2= NVXvU5F{PzKq NFjNXXJFVVOR MX7JR|UxRTFwMTFOwG0> NXnUTmxwOTh2OUS0OlM>
Panc 04.03 Mn;yR5l1d3SxeHnjJGF{e2G7 M1rG[|UxKM7:TR?= NWX6PXBQPzKq Mnv3SG1UVw>? MXLJR|UxRTFwMjFOwG0> MmXINVg1QTR2NkO=
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HeLa NG\Pb2dMcW6jc3WgRZN{[Xl? Ml7MNkBp MVHJcohq[mm2aX;uJI9nKG63Y3zlZZIhUESDQzD3bZRpKEmFNUCgc4YhOC5yOEOg{txO M2WyR|E5PTV6Nk[5
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NB4 NVrFOJV7PDiq NGHjfopFVVOR M2X3S2lEPTB;MD62JO69VQ>? NHL6SGgyQDd{M{O0PS=>
HEK293 Mlr2SpVv[3Srb36gRZN{[Xl? MoXGNVAh|ryP Mo\RNlQhcA>? M4rldmROW09? MU\BZ5RqfmG2aX;uJI9nKG2xdYPlJHdvfDOjIIPp[45idGmwZzDlfJBz\XO|ZXS= Mn\KNVkxOjJ4N{W=
HCT116 NVvaUVFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi3Nog> MoPZSG1UVw>? MoXETWM2OD1yLkOxJO69VQ>? MorFNVkxQDR{OUS=
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IGROV1 NXjFNpV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWi3NkBp M2HaXWROW09? MULJR|UxRTJwMjFOwG0> M2fJV|E6ODh2Mkm0
IGROV1 MmixT4lv[XOnIFHzd4F6 MlPZOUDPxE1? MoXGNlQhcA>? MXnEUXNQ Mm\jTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHB3MzDhZ4V1gWyjdHnvci=> NVzHdYtjOTlyOESyPVQ>
IGROV1 NFGzUZBMcW6jc3WgRZN{[Xl? MVyxNEDPxE1? NEjneZE1KGh? NHm2WXZFVVOR NXTwfZRnUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmVvSESgZYNmfHmuYYTpc44> MUWxPVA5PDJ7NB?=
IGROV1 MUfLbY5ie2ViQYPzZZk> NGX5S3AyOCEQvF2= M1T2OFQhcA>? NUXld4kxTE2VTx?= M1XBTmlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXzwbIEufHWkdXzpckBi[2W2eXzheIlwdg>? MmX2NVkxQDR{OUS=
T24 MUTLbY5ie2ViQYPzZZk> MXSzJIg> NVLPPHZiUW6mdXP0bY9vKG:oIHjpd5RwdmViSEOgZYNmfHmuYYTpc44hf2m2aDDFR|UxKG:oIECuNVIh|ryP NXX2OHlQOTlyOESzPVU>
T24 M{D4cWtqdmG|ZTDBd5NigQ>? MUSzJIg> NIn4TpVKdmS3Y4Tpc44hd2ZiYXzwbIEhfHWkdXzpckBi[2W2eXzheIlwdiC5aYToJGVEPTBib3[gNE4zPSEQvF2= M{\zUlE6ODh2M{m1
HeLa MofCT4lv[XOnIFHzd4F6 MnGyNVUhdWmw M1j6OWROW09? MWHJcohq[mm2aX;uJI9nKEiGQVO2JIZzd21iboXjcIVieiCneITyZYN1KHerdHigTWM2OCCxZjCwMlA5PTVizszN NG\WOIQyQTB7M{i4OC=>
HeLa NVPrWFdsU2mwYYPlJGF{e2G7 M3q5XlE2KG2rbh?= Ml7iSG1UVw>? NEG5SlVKdmirYnn0bY9vKG:oIFjERWM5KG[{b32gcpVkdGWjcjDlfJRz[WO2IIfpeIghUUN3MDDv[kAyNjh4IN88US=> MoLtNVkxQTN6OES=
NCI-H69 MUnDfZRwfG:6aXOgRZN{[Xl? NUXVNmJlPzJiaB?= MoX3SG1UVw>? NHrTVINKSzVyPUKuNFYh|ryP MmnyNVkxQTN6OES=
SKMES1 M1GyUmN6fG:2b4jpZ{BCe3OjeR?= MnL1O|IhcA>? MUXEUXNQ NXXvXXVQUUN3ME2yMlQzKM7:TR?= NYLYOnpxOTlyOUO4PFQ>
S2 NIfFXmxMcW6jc3WgRZN{[Xl? Mlf1NE4yNTFyIN88US=> M4fEN|EhcA>? MYrJcohq[mm2aX;uJI9nKFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDISGFEOSCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFAvODV7IN88US=> MXqxPVMyPzR3MB?=
SHSY5Y NIDGUVFMcW6jc3WgRZN{[Xl? MmrkNVAh|ryP MXK0PEBp NH\PSI9FVVOR NIfufFFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOUDPxE1? MmOxNVk{PDRzN{W=
SHSY5Y NX\vRYxVS3m2b4TvfIlkKEG|c3H5 MmTPNVAh|ryP Mn7GOFghcA>? M4HBemROW09? NIO3c2tKSzVyPUKg{txO NFvNUZoyQTN2NEG3OS=>
DMS114 NEG3UZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[0PEBp NVm0XG5NT0l3ME2yMlkh|ryP NWXQNWh4OTl2MUmyNFU>
HBC5 NV:2OIdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYW0PEBp MUnHTVUxRTF5IN88US=> M1HKRlE6PDF7MkC1
SNB78 NYjUeXp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonTOFghcA>? NFTLR2JIUTVyPUG2JO69VQ>? NXHnc3hZOTl2MUmyNFU>
HeLa MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\xO|IhcA>? M33mTWROW09? M4\JcWlEPTB;MD60OkDPxE1? MkSwNVk1PDF6NE[=
BHK NVvVTVdFU2mwYYPlJGF{e2G7 NGPQTZg2KM7:TR?= NGm0RY4zPCCq MXPEUXNQ NVuwdoprUW6qaXLpeIlwdiCxZjDISGFEPyCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4heGyjc33hJI1mdWK{YX7lJGZl\Wy2YUWwPEBETlSUIIDyc5RmcW5? NXPtbms1OTl7Nk[3PFk>
CFBE41o- MmfzT4lv[XOnIFHzd4F6 M2nmWFUh|ryP MVi4JIg> M3:4fWROW09? M2TLUGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqeYDldoFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEO= MkPtNVk6PjZ5OEm=
CFBE41o- Mmr2T4lv[XOnIFHzd4F6 MlXsOUDPxE1? NFjFd|M1KGh? M{KwUGROW09? NXrPVVBGUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJI12fGGwdDDG[IVtfGF3MEigR2ZVWiCycn;0[YlvKGyndnXs M3[xeFE6QTZ4N{i5
CFBE41o- MY\LbY5ie2ViQYPzZZk> NYOzVIF7OSEQvF2= M3jDelEhcA>? MoG3SG1UVw>? M2T0bmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDDSnRTKHC{b4TlbY4hdGW4ZXy= NUC0fXJYOTl7Nk[3PFk>
Primary bronchial epithelial cell MY\LbY5ie2ViQYPzZZk> Ml;JNUDPxE1? NVzUcZpJOjRiaB?= M4i5c2ROW09? MXfJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDteZRidnRiRnTlcJRiPTB6IFPGWHIheHKxdHXpckBieGmlYXygd5Vz\mGlZTDsc4NidGm8YYTpc44> Ml6wNVk6PjZ5OEm=
CFBE41o- MlGzT4lv[XOnIFHzd4F6 MmHSNUDPxE1? MnXaOUBl[Xm| NXXXPVJxTE2VTx?= NELubpRKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJN1[WKrbHn6ZZRqd25ib3[gSoRmdHSjNUC4JGNHXFJicILveIVqdg>? NXf5PVNvOTl7Nk[3PFk>
CFBE41o- MWnLbY5ie2ViQYPzZZk> NXLvNYxqOSEQvF2= MoLXNlQhcA>? NHHDZ2xFVVOR NFz3SGFKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGZl\Wy2YUWwPEBETlSUIIDyc5RmcW5idILh[oZq[2urbne= NYTJ[nZTOTl7Nk[3PFk>
CFBE41o- NXTtU5llU2mwYYPlJGF{e2G7 NGnSVWI2KM7:TR?= MX6yOEBp MXLEUXNQ NFTIfoRKdmirYnn0bY9vKG:oIFjERWM4KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJJifGVib3[gcYF1fXKjdHnvckBw\iCFRmTSJJBzd3SnaX6geI8hcXS|IHfsfYNw\m:{bR?= MmTLNVk6PjZ5OEm=
CFBE41o- NUTWN|RqU2mwYYPlJGF{e2G7 MVq1JO69VQ>? M2\tdVI1KGh? MnWzSG1UVw>? M1zVXGlvcGmkaYTpc44hd2ZiSFTBR|ch[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gd5Ri[mmuaYT5JI9nKE[mZXz0ZVUxQCCFRmTSJJBzd3SnaX6= M3\NTlE6QTZ4N{i5
CFBE41o- MmjpT4lv[XOnIFHzd4F6 MYm1JO69VQ>? NWrKbmo3OjRiaB?= NILsXnhFVVOR MkjhTY5pcWKrdHnvckBw\iCKRFHDO{Bie3Onc4Pl[EBieyClb4Ly[YN1cW:wIH;mJI12fGGwdDDG[IVtfGF3MEigR2ZVWiC2cnHm[olkc2mwZzD0c{Bk\WyuIIP1doZi[2ViYYOg[4x6[2:ob4Lt NUDVbo93OTl7Nk[3PFk>
Primary bronchial epithelial cell Ml7DT4lv[XOnIFHzd4F6 Mn7rOUDPxE1? Mm\2NlQhcA>? M124cWROW09? NXX2Z2NqUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBufXSjboSgSoRmdHSjNUC4JGNHXFJicILveIVqdiCjcHnjZYwhe3W{ZnHj[UBtd2OjbHn6ZZRqd25? MVmxPVk3Pjd6OR?=
Primary bronchial epithelial cell NV73NGpnU2mwYYPlJGF{e2G7 NVTqN5JNOSEQvF2= NFHLW5g6PiCq M4rNPGROW09? MXzJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIPoc5J1KGOrcnP1bZQh[3W{cnXueJM> NVW0eJdzOTl7Nk[3PFk>
BxPC3 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVW3NkBp NH\te4lKSzVyPUKuO{DPxE1? MXmyNFE1Ozd5OB?=
CAL27 NELyZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGxO|IhcA>? NYe2eVRDUUN3ME2zMlczKM7:TR?= NX3hSndWOjBzNEO3O|g>
Capan1 MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTUVGl3PzJiaB?= M3PjPGlEPTB;Nz6zJO69VQ>? MnzRNlAyPDN5N{i=
HCC827 NFWwPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD4OmU4OiCq NV\NWYpoUUN3ME2xMlgh|ryP MXuyNFE1Ozd5OB?=
LNCAP NWS2V4dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TvblczKGh? MXHJR|UxRTBwNUig{txO NFO3SmEzODF2M{e3PC=>
NCI-H2122 NHXXOXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fLfFczKGh? NF3uOoVKSzVyPUeuOUDPxE1? NXHSTZZHOjBzNEO3O|g>
NCI-H358 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHJO|IhcA>? M3\DZ2lEPTB;Mj61JO69VQ>? M{jZO|IxOTR|N{e4
SCC15 M{PuV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGxfHY4OiCq M3qyVGlEPTB;Mj60PUDPxE1? MVyyNFE1Ozd5OB?=
SCC25 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4CzclczKGh? NYDIdIJwUUN3ME2xMlk{KM7:TR?= NHy4O4QzODF2M{e3PC=>
SKHEP1 MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzKUYd2PzJiaB?= M2LzTmlEPTB;Mz60OkDPxE1? MkPyNlAyPDN5N{i=
BJ NUGyVJVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\TWldtOTByIN88US=> M{XlNlQ5KGh? MWrEUXNQ M4npOGdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN MoDpNlAyPDN6NEC=
MUF MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTCbmdJOTByIN88US=> MonPOFghcA>? MWPEUXNQ NX7relVRT3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> MnGwNlAyPDN6NEC=
Caco-2 NUXWUW4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TVNVExOCEQvF2= M{jE[VQ5cA>? NFntVXlFVVOR M1jQWmlEPTB;OD6xJO69VQ>? M2C0Z|IxOTR|OESw
Caco-2 M1Tj[mtqdmG|ZTDBd5NigQ>? M3TRNFUh|ryP NVXubIRPPCCq NFHFeFFFVVOR MUPJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN NU\Td4NqOjBzNEO4OFA>
Caco-2 NXnvVYpbU2mwYYPlJGF{e2G7 NXT1dXNSOC5|MU[gcm0hfG9iM{GuOkDPxE1? NV[ybHBJPCCq M4XNeGROW09? MULFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzFid3n0bEBKSzVyIH;mJFAvOTF7IN88US=> M2LNTlIxOTR|OESw
Caco-2 NXqwZoVuU2mwYYPlJGF{e2G7 MkjPNE4{OTZibl2geI8hOzFwNjFOwG0> NITlfFc1KGh? NF\pXXBFVVOR NHeyU5lGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>? NH7yN|QzODF2M{i0NC=>
Caco-2 MlvTT4lv[XOnIFHzd4F6 NUPjNJJUPi5|MjDuUUB1dyB4M{Kg{txO NXuxPIFHPCCq MUHEUXNQ M1nDNWV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNTD3bZRpKEmFNUCgc4YhOTJwNjFOwG0> M4O3NFIxOTR|OESw
Caco-2 NV\IO3llU2mwYYPlJGF{e2G7 MX:2MlMzKG6PIITvJFY{OiEQvF2= MmDZOEBp M1;5R2ROW09? NXn5WnJnTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO3JJdqfGhiSVO1NEBw\iB2MTFOwG0> MkTMNlAyPDN6NEC=
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HepG2 MonQT4lv[XOnIFHzd4F6 NGi0[WM2KM7:TR?= NIfPOIw3cA>? NWDrUVRETE2VTx?= MWfJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u NHnpPGozODF2M{i0NC=>
HepG2 NX3kW28xU2mwYYPlJGF{e2G7 M1q4ZVUh|ryP M1u5SlZp Ml3wSG1UVw>? NIGyXFdKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIh6eGW{YXPleJlt[XSrb36= MVOyNFE1Ozh2MB?=
HepG2 NHv3e3VMcW6jc3WgRZN{[Xl? M13XfVUh|ryP NYnmV21uPmh? NVfD[HNxTE2VTx?= Mlz6TY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NIrlN2UzODF2M{i0NC=>
HepG2 MnPmT4lv[XOnIFHzd4F6 NFrHU4Q2KM7:TR?= Ml;ROog> NX\6cG9sTE2VTx?= M{PYd2lv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= M1XCTFIxOTR|OESw
COLO205 MXjLbY5ie2ViQYPzZZk> MUexNEDPxE1? NFTKO|gzPCCq MlSxSG1UVw>? NHrqd5VKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIIfpeIghUUN3MDDv[kAzNjJizszN NX[0VpMxOjB2NUGzO|g>
SCC4 NGTsNolMcW6jc3WgRZN{[Xl? M2eyZVEh|ryP MWKyOIg> MV;Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5idIXieYxqdiCjY3X0fYxifGmxbh?= M1vDfVIxPDV{MkK1
SCC4 MnfKT4lv[XOnIFHzd4F6 NGLnd5cyKM7:TR?= NWD3UlFsOjSq NEfOdHBKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> M1rmUVIxPDV{MkK1
SCC4 NWDDW5BZTnWwY4Tpc44hSXO|YYm= MVmxJO69VQ>? MW[1JI1qdg>? NIXHNJZC\2:waYP0JIFkfGm4aYT5JIF1KF[GUjDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiQ2nQNlQh\2WwZTDlfJBz\XO|aX;u NWDRcYZUOjB2NUKyNlU>
NB4 NF\Jb2ZHfW6ldHnvckBCe3OjeR?= NIL4XG82KM7:TR?= MoKzNlQhcA>? NWXVfYRtTE2VTx?= NF7mcotE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl NGq5WW0zODR7MUS0NC=>
NB4 M1vZPWtqdmG|ZTDBd5NigQ>? MWe1JO69VQ>? MWqyOEBp M2\3PWROW09? NWDLfVluUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIFk\XS7bHH0[UB1fWK3bHnuJIxmfmWu NHvqeWozODR7MUS0NC=>
NB4 NH\UXINHfW6ldHnvckBCe3OjeR?= MUW1JO69VQ>? NWKwXXpmOjRiaB?= MU\EUXNQ NVzEfZIzUW6mdXP0bY9vKG:oIICyNXdCTjFxQ1nQNUBmgHC{ZYPzbY9v NYCw[XI3OjB2OUG0OFA>
NB4 MYrLbY5ie2ViQYPzZZk> M3e5cFUh|ryP Ml:wNlQhcA>? MWnEUXNQ NUXON|JtUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMh[WOndInsZZRqd25? NIDKPG8zODR7MUS0NC=>
NUGC3 M3XnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DVT2dKPTB;Mj65OEDPxE1? NWDDZoZJOjB6NUC5O|E>
A549 M{\iO2Z2dmO2aX;uJGF{e2G7 MoXGOUDPxE1? MoLiN{Bp MUPEUXNQ NGHkbYVKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> M{KzN|IxQDV3MkC4
HUT78 NXfNdZJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHtO|IhcA>? NY\rV3c3TE2VTx?= MofVS2k2OD1yLkOg{txO NGfSVVQzODh6NEKwPC=>
U937 NF3ZR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW3UnNvPzJiaB?= NYDjNmVZTE2VTx?= NI\kVoxIUTVyPUCuN|kh|ryP Ml;XNlA5QDR{MEi=
A431 Moe0R5l1d3SxeHnjJGF{e2G7 Mn;mO|IhcA>? M4PNbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gOE4zKM7:TR?= NVP1V3hDOjFyOEC2Nlk>
A549 NGHxdGdEgXSxdH;4bYMhSXO|YYm= MXS3NkBp NU\v[FgyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN MlHRNlExQDB4Mkm=
CAL27 M{TlW2N6fG:2b4jpZ{BCe3OjeR?= MXO3NkBp M3rhZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2= MmjsNlExQDB4Mkm=
HeLa MkiyR5l1d3SxeHnjJGF{e2G7 NVW4dFEyPzJiaB?= MoK5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlUh|ryP MVeyNVA5ODZ{OR?=
Sf21 M37mUmtqdmG|ZTDBd5NigQ>? MWmzJIg> M1nte2lvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN Mmf5NlExQDB4Mkm=
SKBR3 MlHsR5l1d3SxeHnjJGF{e2G7 NFzle4Y4OiCq MkfWR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= NWGxUZVSOjFyOEC2Nlk>
SKOV3 MljrR5l1d3SxeHnjJGF{e2G7 MlP3O|IhcA>? M3L3UmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= MVqyNVA5ODZ{OR?=
COR-L23 NVPTS25IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? M1zxd|czKGh? Mnf3SG1UVw>? NVq0NohYT0l3ME2xMlEh|ryP NXrmR5JROjFyOEC2OFc>
DU145 NEjDfVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFX1bpYyOCEQvF2= NGPDb2E4OiCq MV3EUXNQ M3X0T2dKPTB;MT6wOUDPxE1? M2mxeVIyODhyNkS3
LoVo Mly2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[wbZgyOCEQvF2= MVe3NkBp NFrRTGlFVVOR MnvDS2k2OD1zLkeg{txO NEPte4czOTB6ME[0Oy=>
MCR5-SV2 NGmx[pNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nncFExKM7:TR?= MUC3NkBp NIjtclRFVVOR Mlf4S2k2OD1{LkGg{txO NUfm[ZdvOjFyOEC2OFc>
HCT116 M2\oXWtqdmG|ZTDBd5NigQ>? NXTtWJdzOzBizszN M4XKUlMxKGh? MnHNSG1UVw>? NIjqNmlKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u NH6wO2czOTB6ME[0Oy=>
HCT116 MWPLbY5ie2ViQYPzZZk> MlvLN|Ah|ryP M2nHSlMxKGh? MWXEUXNQ NG\ieXdKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= M2f5N|IyODhyNkS3
U937 MVXLbY5ie2ViQYPzZZk> NX;Lcm4zPSEQvF2= M3jsTFI1KGh? NG\HUGFFVVOR NX3jcIR[UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= MV2yNVI6OjR7Mh?=
U937 MYrLbY5ie2ViQYPzZZk> NHzZUmU2KM7:TR?= NVTOZol5OjRiaB?= M1fifmROW09? NUDDPFduUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NVfYPHc6OjF{OUK0PVI>
U937 M{PBTWtqdmG|ZTDBd5NigQ>? Mn;tOUDPxE1? Mnn0NlQhcA>? MUjEUXNQ M4nIVGlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu MoHPNlEzQTJ2OUK=
U937 Mo\DT4lv[XOnIFHzd4F6 NYqwcGM2PSEQvF2= NXX4dHpTOTVibXnu NVLCW5M3TE2VTx?= NEj3eJdKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? Ml6yNlEzQTJ2OUK=
A2780 NXOwPXV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnoPVYhcA>? NIXnWW9FVVOR MXzJR|UxRTFwNkKg{txO NHHjW4QzOTZ|NESzNC=>
COLO205 NHvqR29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYO5OkBp NH3zOnZFVVOR MkP0TWM2OD1{LkGyJO69VQ>? M36w[lIyPjN2NEOw
Hep3B MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHUXlBlPDhiaB?= M1vkemROW09? MmTPS2k2OD1zLkKxJO69VQ>? NVHhfZc{OjF5MUKxOFY>
GM11272 MYLGeY5kfGmxbjDBd5NigQ>? NEnveFgyODBibl2= NH71fGI4OiCq NWTWUllLTE2VTx?= M1zUe3Jm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> M2izZ|IyQDRyN{G2
CFBE41o M1\ZR2tqdmG|ZTDBd5NigQ>? NFPTNpY2KM7:TR?= M3HjbmROW09? NV\Ddoo{TG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP NYexeYpHOjF7OES5OVg>
CFBE41o Mn;ESpVv[3Srb36gRZN{[Xl? NWfnVHZGOSEQvF2= M2LDXlI1KGh? NWPPO2NrTE2VTx?= MmfUVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| MnrqNlE6QDR7NUi=
DU145 MonET4lv[XOnIFHzd4F6 MWKyMlUh|ryP M2PDeVI1KGh? NXLo[YdGTE2VTx?= M{fObWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> MWSyNlI3ODF4Nh?=
DU145 MlnMT4lv[XOnIFHzd4F6 NEDXTpA2KM7:TR?= MWKyOEBp M3OzbmROW09? Mon0TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= M13vTVIzOjZyMU[2
DU145 M1O2WGtqdmG|ZTDBd5NigQ>? Mn30OUDPxE1? MmixNlQhcA>? MkjaSG1UVw>? MoG1TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? NXrHcnZrOjJ{NkCxOlY>
786-0 NEHl[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlUog3NjJizszN MVe3NkBp MVLEUXNQ MnnkS2k2OD1|LkKg{txO NUPZcWprOjJ2M{W2Olk>
A498 NFvtWYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\iRlYvOiEQvF2= MWe3NkBp MUHEUXNQ M3jkcmdKPTB;MT62JO69VQ>? Ml\oNlI1OzV4Nkm=
A549/ATCC NYj0e4loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTHOk4zKM7:TR?= NFy4Too4OiCq M{LNfGROW09? MWDHTVUxRTFwNjFOwG0> NVPFcXJvOjJ2M{W2Olk>
ACHN NH\5SWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rONVYvOiEQvF2= MUC3NkBp M2C5fWROW09? NUPTTVNST0l3ME2xMlMh|ryP NX7HW4FMOjJ2M{W2Olk>
BT549 NWTPeItCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T0fVYvOiEQvF2= MUO3NkBp MoH6SG1UVw>? MmXGS2k2OD1zLkOg{txO MVmyNlQ{PTZ4OR?=
EKVX NGny[|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL4PXg6Pi5{IN88US=> MmXQO|IhcA>? MmrZSG1UVw>? NXLCVWJJT0l3ME2xMlMh|ryP M2fLcFIzPDN3Nk[5
HCT15 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzzR4E3NjJizszN NWW3cmdyPzJiaB?= MlnpSG1UVw>? MXrHTVUxRTJwNTFOwG0> MmG1NlI1OzV4Nkm=
HOP92 NEm3OIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUG2MlIh|ryP MYO3NkBp MUjEUXNQ Ml3HS2k2OD12IN88US=> MkH2NlI1OzV4Nkm=
IGROV1 Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\LUFVbPi5{IN88US=> M{jz[lczKGh? MWnEUXNQ M17DNWdKPTB;MT6zJO69VQ>? M1LtWFIzPDN3Nk[5
LOXIMVI NUHTfm8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLuOk4zKM7:TR?= MljjO|IhcA>? MX7EUXNQ NH;1PFFIUTVyPUGg{txO NVvteHhCOjJ2M{W2Olk>
M14 NVX0VlVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfJbZQ3NjJizszN NVnzbJN5PzJiaB?= NFPBbppFVVOR M3zVXWdKPTB;MT6zJO69VQ>? MX6yNlQ{PTZ4OR?=
MALME-3M MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f0VlYvOiEQvF2= NXO4WoJJPzJiaB?= NWPzSVNTTE2VTx?= MnXJS2k2OD1yLkOyJO69VQ>? MYqyNlQ{PTZ4OR?=
MCF10A NXn6UYRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;mflYvOiEQvF2= Ml:xOFghcA>? M1fJb2ROW09? MkGzS2k2OD17Lk[g{txO NIK0dWszOjR|NU[2PS=>
MDA-MB-435 NIXVRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;DOk4zKM7:TR?= MlnhO|IhcA>? Ml;mSG1UVw>? NVv0WXo4T0l3ME2wMlUh|ryP NGTkWI4zOjR|NU[2PS=>
MDA-MB-468 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fCXFYvOiEQvF2= Mn;LO|IhcA>? M1;rSGROW09? NVLDWFdwT0l3ME2wMlY{KM7:TR?= M4LMTVIzPDN3Nk[5
MOLT4 M3:1dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3TUG9oPi5{IN88US=> MmC5O|IhcA>? NHm0eWlFVVOR NH:yb4xIUTVyPUCuOEDPxE1? NYHsXFR{OjJ2M{W2Olk>
NCI-ADR-RES NGHBOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jZOFYvOiEQvF2= NHTTR4s4OiCq NGHsZmFFVVOR M4TsRmdKPTB;MD6xOkDPxE1? M3LoS|IzPDN3Nk[5
NCI-H23 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjSOk4zKM7:TR?= NI\2SWQ4OiCq NU\Ge5pMTE2VTx?= NFXGWFdIUTVyPUGg{txO MnXGNlI1OzV4Nkm=
NCI-H322M NGPpTI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETlTWw3NjJizszN NYjmZ4Y6PzJiaB?= NYHtZYNETE2VTx?= NX3FNGI4T0l3ME2wMlc6KM7:TR?= M3;K[lIzPDN3Nk[5
NCI-H460 MmPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPmcZg3NjJizszN NIrCToQ4OiCq M4TjPGROW09? MX7HTVUxRTBwN{mg{txO MnXSNlI1OzV4Nkm=
NCI-H522 NFq3b5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFy0blY3NjJizszN MmHGO|IhcA>? MWrEUXNQ MVPHTVUxRTBwNTFOwG0> MVmyNlQ{PTZ4OR?=
OVCAR3 M3Ozd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX[2MlIh|ryP MXy3NkBp M4f5XGROW09? NH;2PW5IUTVyPUGuN{DPxE1? M3TUOFIzPDN3Nk[5
OVCAR4 M2nCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HUUlYvOiEQvF2= Ml60O|IhcA>? MXnEUXNQ M4\semdKPTB;NDFOwG0> NYLhOmVPOjJ2M{W2Olk>
OVCAR5 MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:2MlIh|ryP NGjl[Ww4OiCq MmLDSG1UVw>? NX:4VI9iT0l3ME2wMlc6KM7:TR?= MWOyNlQ{PTZ4OR?=
OVCAR8 NUHSZVJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:2MlIh|ryP MXy3NkBp NGDiSGVFVVOR MV;HTVUxRTBwNTFOwG0> NVH0Wmk3OjJ2M{W2Olk>
RXF393 MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LHVlYvOiEQvF2= MorpO|IhcA>? NHyzbZhFVVOR MXLHTVUxRTFwMzFOwG0> MVOyNlQ{PTZ4OR?=
SF268 NGDMWJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDGW25ZPi5{IN88US=> NXzvZo95PzJiaB?= MlXQSG1UVw>? Mo[zS2k2OD1zLk[g{txO NVjRfodjOjJ2M{W2Olk>
SF295 NFfMNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDjVFI3NjJizszN NIPJTmQ4OiCq NUfB[Vg1TE2VTx?= MU\HTVUxRTFwNjFOwG0> NY\uXmhoOjJ2M{W2Olk>
SF539 M{fnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfXOk4zKM7:TR?= NGezbHo4OiCq MonOSG1UVw>? MWjHTVUxRTJizszN M2rjclIzPDN3Nk[5
SK-MEL-2 M4TCTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWD6XWp4Pi5{IN88US=> M3zHSVczKGh? MWjEUXNQ NFy2[ZJIUTVyPUGuN{DPxE1? NV\zdJU4OjJ2M{W2Olk>
SK-MEL-28 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[2MlIh|ryP NUX1ZlBvPzJiaB?= NH30e5dFVVOR MXrHTVUxRTFizszN NF;oeoszOjR|NU[2PS=>
SK-MEL-5 NEHp[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W5PVYvOiEQvF2= Mor3O|IhcA>? M{jINGROW09? NX70TYRvT0l3ME2wMlY{KM7:TR?= NIL3OZYzOjR|NU[2PS=>
SKOV3 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHNdWw3NjJizszN MVi3NkBp MYnEUXNQ MmfKS2k2OD1zIN88US=> MkG0NlI1OzV4Nkm=
SN12C MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojkOk4zKM7:TR?= MVK3NkBp MYHEUXNQ MnSwS2k2OD1{IN88US=> MmDaNlI1OzV4Nkm=
SNB19 NWq1NY84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvEUG43NjJizszN MnrPO|IhcA>? NX3WUXdqTE2VTx?= NH\IPXdIUTVyPUCuOlMh|ryP MVOyNlQ{PTZ4OR?=
SNB75 MnLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUS2MlIh|ryP MYC3NkBp MmO3SG1UVw>? MnfCS2k2OD1yLke5JO69VQ>? NXPlUIo1OjJ2M{W2Olk>
SR Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO2MlIh|ryP Mm\oO|IhcA>? M3PkeWROW09? NVW3UIZGT0l3ME2wMlQh|ryP Mme5NlI1OzV4Nkm=
T47D MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\Sb|YvOiEQvF2= MYm3NkBp MnHjSG1UVw>? M2LG[WdKPTB;MD61JO69VQ>? MnziNlI1OzV4Nkm=
TK10 MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[5TlYvOiEQvF2= NV;aOnltPzJiaB?= NGjVZYlFVVOR M2TiOWdKPTB;MD62N{DPxE1? NWO0dHI5OjJ2M{W2Olk>
UACC257 MoDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP2R5ZoPi5{IN88US=> MlrQO|IhcA>? MUPEUXNQ MkjTS2k2OD1yLkWg{txO NGHNTZkzOjR|NU[2PS=>
UACC62 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVu2MlIh|ryP MlO0O|IhcA>? M3vWSmROW09? M2DBTWdKPTB;MD60JO69VQ>? NVe1bVZQOjJ2M{W2Olk>
UO31 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTyOk4zKM7:TR?= MljLO|IhcA>? M4T1c2ROW09? MVPHTVUxRTBwNTFOwG0> MnTVNlI1OzV4Nkm=
Hep3B NUPQXXc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm0PEBp NIrPdW9FVVOR M1q5SmdKPTB;MD62PUDPxE1? MVuyNlQ{QTh4Mx?=
BE(2)-C MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLaTXg4OiCq NGPzelVFVVOR NGO3b2xKSzdyPUKg{txO MmniNlI6OzJ|MU[=
Bel7402 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTnPJE4OiCq NGjmRZRFVVOR MUXHTVkxRTF5IN88US=> NES4fWczOzB4MUO3Oi=>
Bel7404 M2LYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEm2XYo4OiCq NIn2S5hFVVOR NVnhU3lzT0l7ME2xPEDPxE1? MXqyN|A3OTN5Nh?=
BGC823 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvwO|IhcA>? M{Cyd2ROW09? M4DEbWdKQTB;Nz61JO69VQ>? NGfp[4kzOzB4MUO3Oi=>
MGC803 NWHBVIRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\OZpA4OiCq NYXL[2x1TE2VTx?= MnH1S2k6OD1zMD64JO69VQ>? M3;IelI{ODZzM{e2
SGC7901 NYrzNI8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV23NkBp NETV[YZFVVOR M330UmdKQTB;OT60JO69VQ>? MkL4NlMxPjF|N{[=
SKHEP1 Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXi3NkBp MmHmSG1UVw>? MmCwS2k6OD1zNzFOwG0> NFKyV4YzOzB4MUO3Oi=>
SMMC7721 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PudFczKGh? Mlq1SG1UVw>? MV3HTVkxRTJyIN88US=> NV\nNlBJOjNyNkGzO|Y>
NUGC3 NHTXWnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvMNVAh|ryP NFzZZoZIUT1{Lkm0JO69VQ>? NX;nPFRGOjNzNkOzN|I>
A2780 CisR MoruT4lv[XOnIFHzd4F6 MkXnNVghcA>? NIHY[I9KdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP MojQNlMzPTJ4MEO=
CAL27 sens Mk[1T4lv[XOnIFHzd4F6 NV2zTlJvOThiaB?= NV7tWlZ5UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= NHnkb2kzOzJ3Mk[wNy=>
CAL27 CisR Mn7UT4lv[XOnIFHzd4F6 NHPwS20yQCCq MX3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MVOyN|I2OjZyMx?=
KYSE-510 CisR M2i1RWtqdmG|ZTDBd5NigQ>? MnTLNVghcA>? NY[3OZgzUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= M2rZWVI{OjV{NkCz
KYSE-510 sens MVfLbY5ie2ViQYPzZZk> M2rsV|E5KGh? MkPUTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO NU\5SJBROjN{NUK2NFM>
MDA-MB-231 sens NGSwfmpMcW6jc3WgRZN{[Xl? NEXzfHgyQCCq M4TGSWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NVXVWo5IOjN{NUK2NFM>
MDA-MB-231 CisR NIrqOphMcW6jc3WgRZN{[Xl? M4OwNlE5KGh? NEfJZ3FKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NEm1bmIzOzJ3Mk[wNy=>
ES2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXruSFdRPDhiaB?= NIjTVHhFVVOR M2rnd2lEPTB;MUKuO{DPxE1? MXOyN|Q6OzR2OR?=
MDA-MB-231 MVjLbY5ie2ViQYPzZZk> NE\wOW4yOCEQvF2= MUWzNEBucW5? MoLWSG1UVw>? MlXLTY5pcWKrdHnvckBw\iCKRFHDNoE> M1LoUVI{PDl|NES5
MDA-MB-231 NY\ObHRqU2mwYYPlJGF{e2G7 NHH1XIUyKM7:TR?= MkDCNlQhcA>? NGjxOHBFVVOR NH6ySZBKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu M{Pid|I{PDl|NES5
HS68 NFX3NWtEgXSxdH;4bYMhSXO|YYm= NW\XfGVKOTBizszN M{HmfVczKGh? M1jmZWROW09? NFrWVHFKSzVyPUSuOkDPxE1? MlHENlM2PzB3NEK=
MEF NXqySWtzS3m2b4TvfIlkKEG|c3H5 NU\LO206OTBizszN NUDWZ4gyPzJiaB?= M3HKXWROW09? M13zSWlEPTB;ND60JO69VQ>? M{PJS|I{PTdyNUSy
BGC823 MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7EUXNQ MVLHTVUxRTNwMEmg{txO Mn71NlM3ODF5ME[=
High5 MmrPT4lv[XOnIFHzd4F6 NYfWXoFCOjRiaB?= MYnJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? MV6yN|YxOjV{Mx?=
High5 MkjST4lv[XOnIFHzd4F6 NFXJbIwzPCCq MUHJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NFPoPZEzOzZyMkWyNy=>
High5 NV3HTFdpU2mwYYPlJGF{e2G7 NIj6e|EzPCCq M33ScGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP MX2yN|YxOjV{Mx?=
A549 NFzBdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnifnBKTE2VTx?= MUHJR|UxRTFwMEe5JO69VQ>? NHy1dmgzOzZ2NEKxNC=>
HCT116 M{P0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTUVYc5TE2VTx?= NYK4S5FyUUN3ME2wMlc2PyEQvF2= Ml7pNlM3PDR{MUC=
K562 NIe3[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvQUWVFVVOR Moj0TWM2OD1yLk[0OUDPxE1? M4LRZVI{PjR2MkGw
GBC-SD MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITOOG82KM7:TR?= MkTCO|IhcA>? MmmxSG1UVw>? MX7JR|UxRTF2Lkig{txO MV[yN|cxPzJ4MB?=
HGC27 M17VVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT4UHE2KM7:TR?= MV[3NkBp NVjlTox6TE2VTx?= NEOzeHJKSzVyPUWuOEDPxE1? NY\Xe2xiOjN5MEeyOlA>
HL60 MXnLbY5ie2ViQYPzZZk> MVG1JO69VQ>? MojXNlQhcA>? MlvvSG1UVw>? MY\Jcohq[mm2aX;uJI9nKEiGQVO= MY[yN|cxPzJ4MB?=
Vero MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m5TlczKGh? MYTEUXNQ NYTOXox4UUN3ME2wMlkh|ryP NUPm[YRuOjN5OE[0OVI>
NCI60 NXn0[41bS3m2b4TvfIlkKEG|c3H5 NEj6c4g1QCCq NV3nfldqTE2VTx?= MkP5S2k:OC53MzFOwG0> MViyOFAyPTN{Nx?=
SW620 MlLJR5l1d3SxeHnjJGF{e2G7 NGn4NpM1QCCq NGiweo1FVVOR NYr1UJgxT0l;MD61OEDPxE1? MnXsNlQxOTV|Mke=
U251 NWLMbJNtS3m2b4TvfIlkKEG|c3H5 NUjFXldRPDhiaB?= M36xTWROW09? NGnlR4lIUT1zLkWzJO69VQ>? NUTIZWxNOjRyMUWzNlc>
KM12 NUK3cWNuS3m2b4TvfIlkKEG|c3H5 NUDKcIdDPDhiaB?= NH3ieYdFVVOR M2XCZmdKRTFwOEig{txO M1PQNFI1ODF3M{K3
Hs578T M4HSbGN6fG:2b4jpZ{BCe3OjeR?= NFzaUnQ1QCCq MUjEUXNQ Mn\zS2k:PC56MzFOwG0> M4TxflI1ODF3M{K3
MDA-MB-231 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYO0PEBp MYDJR|UxRTBwMU[g{txO MUCyOFA6PTBzNh?=
MCF7 Mn\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnMboVLPDhiaB?= Mln1S2k:OC52NTFOwG0> MVGyOFEyQTV3NR?=
MDA-MB-435 NGDmVFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[0PEBp NIrORnNIUT1yLki4JO69VQ>? NYWwVWlFOjRzMUm1OVU>
AsPC1 NHH0fYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLHOVdGOzBizszN NHe4PXM1QCCq MofuSG1UVw>? M1vkeWlEPTB;Mz62OkDPxE1? MmjXNlQyQDV|N{i=
Jurkat E6.1 MlroT4lv[XOnIFHzd4F6 MVWyJIg> NGfnV|VFVVOR M{nOdGlvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP NFvNUoQzPDJ4MUi2Ni=>
KG1 M2f4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[5Tno1QCCq MnfDTWM2OD1zLkG1JO69VQ>? NX\hR20xOjR3MkWwNFM>
HEL Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUO0PEBp M2DOXGROW09? NWftT2Y3UUN3ME2wMlQ6KM7:TR?= NIHLUnEzPDZ7NEC1OS=>
HSC3 MkPZR5l1d3SxeHnjJGF{e2G7 MUixNkBp NFGzNoJFVVOR MkfmTWM2OD1yLkexJO69VQ>? NVXLW25{OjR5Nk[1OlA>
HT-29 NUTOXopiS3m2b4TvfIlkKEG|c3H5 M2HGbVEzKGh? MV3EUXNQ NXm3U|QzUUN3ME2wMlczKM7:TR?= MljsNlQ4PjZ3NkC=
KB M2fBcmN6fG:2b4jpZ{BCe3OjeR?= NGCyZngyOiCq NETNT|lFVVOR M2TJN2lEPTB;MD63OUDPxE1? MmLsNlQ4PjZ3NkC=
H460 M1X6N2N6fG:2b4jpZ{BCe3OjeR?= MW[xNkBp NFu2PJJFVVOR M3fvVmlEPTB;MD64NkDPxE1? Ml;3NlQ4PjZ3NkC=
MONE1 M3TuTWN6fG:2b4jpZ{BCe3OjeR?= M13KTVEzKGh? M4rve2ROW09? NYnNNHdwUUN3ME2xMlE5KM7:TR?= Mm\0NlQ4PjZ3NkC=
MKN45 NGPPd2REgXSxdH;4bYMhSXO|YYm= M1;SUlEzKGh? MXfEUXNQ NULGZ5J[UUN3ME2xMlI2KM7:TR?= NXHuRWQ3OjR5Nk[1OlA>
TSGH MnTER5l1d3SxeHnjJGF{e2G7 NV7FTJZFOTJiaB?= NXW3cVJVTE2VTx?= NEXzSIJKSzVyPUKuNFkh|ryP MkLpNlQ4PjZ3NkC=
HL60 Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPmSnVsPzJiaB?= MW\EUXNQ MXnHTVUxRTBwOUOg{txO M4m4OlI1QTByNUCw
HEK293 NGXTU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPFNJU4OiCq NIXoeYVFVVOR NEPzN|NIUTVyPUGzJO69VQ>? M{DXcVI1QTByNUCw
Jurkat NVe4SnhCS3m2b4TvfIlkKEG|c3H5 MX[xNFAh|ryP NWXlXIw2PzJiaB?= NG\hc2RIUTVyPUCuPUDPxE1? NWrpOYt7OjR7MEC3OFM>
GM15850 MofNT4lv[XOnIFHzd4F6 Mo\kNk42KM7:TR?= MlrUPVYhcA>? MnHRSG1UVw>? M2DwSYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NGizRocyPjl{MUO2Oy=>
GM15850 M1jnTGtqdmG|ZTDBd5NigQ>? MX6yMlUh|ryP NUPOR21rQTZiaB?= M2jibmROW09? NV;RZ3Q2\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDViYXPleJlt[XSrb36gc4YhTliQIHflcoU> NVjjbFFCOTZ7MkGzOlc>
GM15850 M1zXbWtqdmG|ZTDBd5NigQ>? MYeyMlUh|ryP NHv4T4k6PiCq MVPEUXNQ MYfkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M123eFE3QTJzM{[3
GM15850 NU[2N|FRU2mwYYPlJGF{e2G7 NVLzVlhIOi53IN88US=> MkjlPVYhcA>? NFi2fndFVVOR NF\TSYZld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NHy5Z3MyPjl{MUO2Oy=>
GM15850 MWHLbY5ie2ViQYPzZZk> MnHHNk42KM7:TR?= NG\UbWY6PiCq M4rBe2ROW09? MVrkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M2nWblE3QTJzM{[3
GM15850 NEDUSldMcW6jc3WgRZN{[Xl? MV:yMlUh|ryP MVe5OkBp MVzEUXNQ MVzkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWHVe|dyOTZ7MkGzOlc>
GM15850 M4\HUGZ2dmO2aX;uJGF{e2G7 M13TNFUh|ryP MnfqNVIhcA>? M{DjbWROW09? NF;hRXNp[XNibn:g[YZn\WO2IH;uJGZZViCvUl7BJIV5eHKnc4Ppc44> NFmz[ogyPjl{MUO2Oy=>
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NCI-H209 MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHKUHFOUUN3ME23NlkvQSCwTR?= MY\TRW5ITVJ?
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KG-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKwTWM2OD15N{WuOFUhdk1? MmnnV2FPT0WU
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LB1047-RCC NXHPO4RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFwMUizNVIh|ryP NX;RPWw3W0GQR1XS
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A375 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnRfWFKSzVyPUGwMlI1PTJizszN MnS1V2FPT0WU
HCC38 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlexTWM2OD1zMD6zNlIh|ryP MkWzV2FPT0WU
LK-2 M3fGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe3e|JKSzVyPUGwMlQzODhizszN M2jGNnNCVkeHUh?=
SF126 M2TXRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvTW21CUUN3ME2xNE41PzJ5IN88US=> M13HV3NCVkeHUh?=
SK-MEL-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL3WW9xUUN3ME2xNE44QDN6IN88US=> M1WyUHNCVkeHUh?=
ACN M1XjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTFyLki2O|kh|ryP Ml65V2FPT0WU
BB30-HNC NIXGWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\SSGlEPTB;MUCuPFcyOSEQvF2= Moe4V2FPT0WU
NCI-H747 M3zwVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX1dYlwUUN3ME2xNE45PzR4IN88US=> NULKUpBLW0GQR1XS
KYSE-150 NXTRNYRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqyRWhvUUN3ME2xNU4xOzh5IN88US=> NVXyfXdUW0GQR1XS
D-247MG NYS2bHhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXRc5hKSzVyPUGxMlExODlizszN MnPOV2FPT0WU
BxPC-3 NWPkZ413T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj6TWM2OD1zMT6zO|Q4KM7:TR?= M2PrenNCVkeHUh?=
SK-MEL-30 M4rtbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nuXWlEPTB;MUGuOFA4QSEQvF2= MXnTRW5ITVJ?
CAS-1 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFzLkSxNFkh|ryP MojEV2FPT0WU
no-10 M4TuWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTyTWM2OD1zMj6xNlE4KM7:TR?= MnLxV2FPT0WU
NCI-H2405 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj1VG5nUUN3ME2xNk4zODN4IN88US=> NInOdJlUSU6JRWK=
KGN MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn2WmhTUUN3ME2xNk4zQTBzIN88US=> M{HuTnNCVkeHUh?=
BB49-HNC NELMNmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTFO2pwUUN3ME2xNk4{QTV4IN88US=> MY\TRW5ITVJ?
NCI-H1693 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Lhb2lEPTB;MUKuOVgyPiEQvF2= NV;uPXZOW0GQR1XS
RO82-W-1 NUH4UY1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPPTWM2OD1zMz6wOlQ6KM7:TR?= NG\wPIdUSU6JRWK=
CAL-85-1 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ntSWlEPTB;MUOuOFM6QSEQvF2= M3TNfXNCVkeHUh?=
H-EMC-SS Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LoVGlEPTB;MUOuPVExPCEQvF2= MoLMV2FPT0WU
SW1783 M3zPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK1[4g6UUN3ME2xOE4zOzlzIN88US=> MmX4V2FPT0WU
LB771-HNC NIHPd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTF2LkSxPUDPxE1? Mm\xV2FPT0WU
HCC70 NUjITJVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlKyTWM2OD1zND60NlM{KM7:TR?= M1r4[nNCVkeHUh?=
KNS-81-FD MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;NNXZKSzVyPUG0MlcxPDVizszN NWGz[Ho1W0GQR1XS
KYSE-520 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTF2LkmyO{DPxE1? M3LNVHNCVkeHUh?=
TGBC24TKB MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jodGlEPTB;MUSuPVU{QSEQvF2= M1XlbXNCVkeHUh?=
SNB75 NIXaNlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPWTWM2OD1zNT6wO|I6KM7:TR?= MoDsV2FPT0WU
SW872 NWPOfItZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF3LkKyNVgh|ryP M3vTNXNCVkeHUh?=
U031 M4q3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn6yTWM2OD1zNT64NFI5KM7:TR?= M3Ly[3NCVkeHUh?=
ChaGo-K-1 M1LZR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jmNGlEPTB;MUWuPFM2QSEQvF2= MkXFV2FPT0WU
NCI-H441 MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofXTWM2OD1zNj6wNFM6KM7:TR?= NVHndoZTW0GQR1XS
TE-12 NXmzbVBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHQXWpKSzVyPUG2MlE5PzNizszN NVPu[pJmW0GQR1XS
NCI-H1755 M17p[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3KXJdKSzVyPUG2MlU4OyEQvF2= M2i3UnNCVkeHUh?=
KNS-42 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33tNWlEPTB;MU[uOlU5QSEQvF2= NXrRS2xxW0GQR1XS
SK-PN-DW M{TzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF5LkSyNFEh|ryP NFeyWlZUSU6JRWK=
NCI-H226 NUT3XoZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXNTWM2OD1zNz65N|Q2KM7:TR?= NEK5Z2lUSU6JRWK=
K-562 M2fyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF6Lk[zNVch|ryP M{PWe3NCVkeHUh?=
A388 M1HrWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEW3RZVKSzVyPUG5MlA{ODNizszN M4DtV3NCVkeHUh?=
ZR-75-30 M4XSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLtTWM2OD1zOT6wPVY5KM7:TR?= M2Ti[nNCVkeHUh?=
LU-135 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPPd2JDUUN3ME2xPU4zPjN4IN88US=> MnT3V2FPT0WU
NCI-H2029 M4nZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjCe5VQUUN3ME2xPU43ODJzIN88US=> MWTTRW5ITVJ?
HT-1197 NWfjc2RRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF7LkmyNlch|ryP M2HHdnNCVkeHUh?=
IGR-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv5Sm5KSzVyPUKwMlMyOTdizszN MmrVV2FPT0WU
U-87-MG Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fWXWlEPTB;MkCuOlQyOyEQvF2= MoDQV2FPT0WU
NCI-H1304 M4fMNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPRTWM2OD1{MD63OVAyKM7:TR?= NInuZnlUSU6JRWK=
RCC10RGB NEDWXWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jBVGlEPTB;MkGuNlgzQSEQvF2= M1TsOnNCVkeHUh?=
NCI-H520 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJ{Lke2NVEh|ryP MVfTRW5ITVJ?
SK-LU-1 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDheJhKSzVyPUKzMlA4OThizszN Mm\PV2FPT0WU
UACC-893 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7X[GxMUUN3ME2yN{4yODN6IN88US=> NY\BTHJwW0GQR1XS
NCI-H2347 NI\ufopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ|LkK2O|Qh|ryP NVT3cIF7W0GQR1XS
U-118-MG M2riTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXqTWM2OD1{Mz63NlE4KM7:TR?= MmOyV2FPT0WU
NCI-H596 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjINHZZUUN3ME2yN{46ODV3IN88US=> NWTXUnM2W0GQR1XS
MZ1-PC NH3OTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jMOGlEPTB;MkSuOlc2QSEQvF2= NFnYTWdUSU6JRWK=
SW1417 M{jtOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrzT4FJUUN3ME2yOU4zPDl6IN88US=> NYXjTXY4W0GQR1XS
NCI-H82 NYDWOWZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfrc4gyUUN3ME2yOk41Ojh6IN88US=> NH2xVmtUSU6JRWK=
COLO-678 MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJ5LkS5NVkh|ryP MmrQV2FPT0WU
KURAMOCHI NH3Pe|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L1[mlEPTB;MkiuNVI3KM7:TR?= MUPTRW5ITVJ?
NCI-H1650 NFnxeohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7YTWM2OD1|MD6xPVI1KM7:TR?= MnO2V2FPT0WU
HCC1954 NEGwUXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNzLkO2OlYh|ryP M1HZfnNCVkeHUh?=
GAK MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\tNmlEPTB;M{KuNlYyPiEQvF2= MoPiV2FPT0WU
YAPC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;4fXFKSzVyPUOzMlc3PDhizszN NX\wS5pFW0GQR1XS
NCI-H2228 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\tTWM2OD1|ND6zOlA2KM7:TR?= NIPhPIdUSU6JRWK=
VMRC-RCZ M1f5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTN4LkOwNlIh|ryP NEXDRVlUSU6JRWK=
NMC-G1 M1ewTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzYTWM2OD1|Nz6wOVI6KM7:TR?= MmnUV2FPT0WU
D-336MG MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTFOZl2UUN3ME20NU45PDR{IN88US=> Ml7JV2FPT0WU
UACC-62 M3\aWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XQR2lEPTB;NEKuOVUxPSEQvF2= NFXwOYNUSU6JRWK=
C-33-A NHPQb2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR3LkOyOVYh|ryP NIfnPYVUSU6JRWK=
HCC1937 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLOZVNKSzVyPUS3MlE6PThizszN Mn;UV2FPT0WU
HDLM-2 NIHvb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\DTWM2OD12Nz6yNlg4KM7:TR?= Mn\PV2FPT0WU
NCI-H727 M1vQSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTR5LkK0OVEh|ryP NHzyS45USU6JRWK=
NY M{\0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELqUFhKSzVyPUS5MlM6ODhizszN MlzWV2FPT0WU
NCI-H2291 M2PMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjJ[oNKSzVyPUS5Mlg{ODFizszN M{mxd3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01281176 Active not recruiting Adult Solid Neoplasm National Cancer Institute (NCI) February 9 2011 Phase 1
NCT01189266 Active not recruiting Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Brain Stem Glioma|Childhood Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma|Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligoastrocytoma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Gliosarcoma National Cancer Institute (NCI) August 9 2010 Phase 1|Phase 2
NCT00703664 Completed Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma National Cancer Institute (NCI) July 9 2008 Phase 2
NCT03198559 Suspended HIV Infections The Peter Doherty Institute for Infection and Immunity|Merck Sharp & Dohme Corp.|The Alfred|University of Melbourne August 8 2017 Phase 1|Phase 2
NCT02538510 Active not recruiting Head and Neck Squamous Cell Carcinoma|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Salivary Gland Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage III Major Salivary Gland Carcinoma|Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage III Nasopharyngeal Carcinoma|Stage IV Nasopharyngeal Carcinoma|Stage IVA Major Salivary Gland Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Major Salivary Gland Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Major Salivary Gland Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma University of Washington|National Cancer Institute (NCI) October 8 2015 Phase 1|Phase 2
NCT01983969 Completed Advanced Cancers|Lymphoma M.D. Anderson Cancer Center November 7 2013 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID