Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 211 Publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MWrLbY5ie2ViQYPzZZk> NUjEU402OSCq MnHMSG1UVw>? MlvrZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP Ml:1NVE6PjB2OEm=
Friend leukemic cell MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrWOVAh|ryP Mm\CO|IhcA>? MVjEUXNQ NUC0NWwzUUN3ME2wMlk6KM7:TR?= MV2xNlExQTlzMx?=
K562 M13WbWtqdmG|ZTDBd5NigQ>? M{XWVFYhcA>? MYLEUXNQ M1vwT2lvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> MXGxNlQyQTN6MB?=
HT1080 NYTRemRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnS0O|IhcA>? Mn7DSG1UVw>? NIDUXHNKSzVyPUKuOEDPxE1? MkTyNVIzPzBzN{W=
H1299 NFP5OHRMcW6jc3WgRZN{[Xl? M3zJWlIxKG2rbh?= NYe0ZYVETE2VTx?= MkHTTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MXqxOFUzOTR{Mh?=
H1299 NFnD[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[xUnl{PzJiaB?= M1S4PGROW09? MYXJR|UxRTdwMkSg{txO NV;PbJdCOTR3MkG0NlI>
HeLa M4LLdWtqdmG|ZTDBd5NigQ>? MlfSN|AhdWmw MYTJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> Mo\6NVU3ODN7NEm=
LOX-IMVI M1S1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP0doNnPDhiaB?= M4G4NmlEPTB;MT6zJO69VQ>? NWX4d4V1OTV5MUW0O|A>
NCI-H226 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHx[lNFPDhiaB?= MWfJR|UxRTJwNjFOwG0> NW\QO5VjOTV5MUW0O|A>
RXF-631L MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWO0PEBp NV7J[3V[UUN3ME2yJO69VQ>? M4fqeVE2PzF3NEew
SNB-78 NGXvblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TOWFQ5KGh? M1X1cmlEPTB;MU[g{txO NVrJU4lLOTV5MUW0O|A>
St-4 NV7UVI54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG0PEBp MUjJR|UxRTVwMjFOwG0> M331S|E2PzF3NEew
ARP1 NI\C[WxHfW6ldHnvckBCe3OjeR?= NHvvUYszKM7:TR?= MWW2JIg> NX7tfVh3UW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NWjQ[FFPOTR5M{S4NFY>
CEM NVr6cItQU2mwYYPlJGF{e2G7 MkPUNUBp M3rzdmROW09? NX61V2oxUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM{KM7:TR?= NWDhcZZzOTZ2MkCwOlQ>
HCT15 MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVy0PEBp M3L0bGdKPTB;MD64NkDPxE1? MnvNNVY4OjN{Mke=
NCI-H23 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX3NYk1QCCq NFLF[mhIUTVyPUCuPVIh|ryP Ml30NVY4OjN{Mke=
GM15850 MnHlT4lv[XOnIFHzd4F6 NF3SSIwzNjVizszN M3n4XFk3KGh? NVvmVnl2TE2VTx?= M4nYeGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MWOxOlkzOTN4Nx?=
GM15850 NUf2Zm5[U2mwYYPlJGF{e2G7 M4\sXlIvPSEQvF2= NXjIeY17QTZiaB?= NWD5XYxzTE2VTx?= NI[0XmJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NGrkZY8yPjl{MUO2Oy=>
GM15850 NXX2XnlyU2mwYYPlJGF{e2G7 NUXGe3NVOi53IN88US=> MUC5OkBp NUXjfodvTE2VTx?= NVPTR3U3UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NVzWRoZCOTZ7MkGzOlc>
GM15850 NXfHXlhOU2mwYYPlJGF{e2G7 MlTqNk42KM7:TR?= NGjKU4k6PiCq NWjJbWluTE2VTx?= MXHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MmjlNVY6OjF|Nke=
GM15850 M1KyO2tqdmG|ZTDBd5NigQ>? MmO0Nk42KM7:TR?= Mmj4PVYhcA>? M4j0RWROW09? MVjJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MlXRNVY6OjF|Nke=
GM15850 MmPQT4lv[XOnIFHzd4F6 NGfhcWwzNjVizszN NHTBc5E6PiCq MXTEUXNQ NX\wco9uUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M4q3dFE3QTJzM{[3
U937 M2fV[WZ2dmO2aX;uJGF{e2G7 NVHEe2ZlPSEQvF2= MXmyOEBp NGnlWodFVVOR MVPD[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm MVSxO|AxPDdzOB?=
H661 M{TydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPyRpE1QCCq MoPwTWM2OD1zIN88US=> MYexO|E2PzByOR?=
U937 MULGeY5kfGmxbjDBd5NigQ>? NUD4TVkzPSEQvF2= MmPVNlQhcA>? Mk\SSG1UVw>? NF7s[VFKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u Ml;QNVc1PDd5NUC=
U937 MlTPSpVv[3Srb36gRZN{[Xl? NUHTPGRCOSEQvF2= NVrqeI46OjRiaB?= MYLEUXNQ M2\VNGVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u NGfGS40yPzR2N{e1NC=>
RAW264.7 M2PneGZ2dmO2aX;uJGF{e2G7 M4XmcVExKM7:TR?= NX72eZZIOjSq M1u2UpdifGW{ M2e3N2lvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE44PiEQvF2= MYCxO|Q4PzVzOB?=
RAW264.7 M2jU[mZ2dmO2aX;uJGF{e2G7 MUOxNEDPxE1? M1vIelI1cA>? NVv1S3A5f2G2ZYK= NX3SPWdiUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? M{DweFE4PDd5NUG4
SC9 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHDb4M1QCCq Moe0TWM2OD1yLk[wOkDPxE1? Mn;zNVc2ODd{MUm=
ST14A NGXGflRHfW6ldHnvckBCe3OjeR?= NWXiZ4NZPSCwTR?= NHK3c3E4OiCq NULRUGJIUW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? NX\wbpdiOTd3NkW5PVM>
ST14A M2HRfGZ2dmO2aX;uJGF{e2G7 NGjpZoI2KG6P MknYO|IhcA>? Ml;PTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? MkHGNVc2PjV7OUO=
PANC1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYmxJO69VQ>? NGr6XHlKSzVyPUCuOFUh|ryP MnGxNVc2QDh5NES=
PANC1 NELrbnJHfW6ldHnvckBCe3OjeR?= NH7p[pUyKM7:TR?= MofMNlQhcA>? Mmm4TY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? NGWzNVkyPzV6OEe0OC=>
PANC1 NI[0WmFHfW6ldHnvckBCe3OjeR?= MVOxJO69VQ>? NXrxWYFyOjRiaB?= M2Kzc2lv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u Mk\RNVc2QDh5NES=
PT45 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PSUWlEPTB;NDFOwG0> NVTMTWJuOTd3OEi3OFQ>
ACHN NHvmcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWWyNUBp NFfZN|FIUTVyPUCuOlUh|ryP NX3lRlhsOTd4NkK2NFY>
PC3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnaNlEhcA>? NH7tZnVIUTVyPUCuO|Eh|ryP MXixO|Y3OjZyNh?=
A431 MkDVR5l1d3SxeHnjJGF{e2G7 Mon3O|IhcA>? NUX4eHUxUUN3ME20MlIh|ryP M{f5T|E4PjlzN{[z
Cal27 M2T5OWN6fG:2b4jpZ{BCe3OjeR?= M3X4[|czKGh? NWTKVHFxUUN3ME2zMlIh|ryP MVmxO|Y6OTd4Mx?=
CCRF-CEM NVn2ZoloS3m2b4TvfIlkKEG|c3H5 M4rvNVczKGh? NGroW|NKSzVyPUCuPEDPxE1? M{H3Z|E4PjlzN{[z
EOL1 NXzGXZV2S3m2b4TvfIlkKEG|c3H5 M2S3Z|czKGh? MYLJR|UxRTFizszN NEPLR4YyPzZ7MUe2Ny=>
Hec-1-A NYXzXohtS3m2b4TvfIlkKEG|c3H5 NYraOXVNPzJiaB?= NWHTSXFrUUN3ME2xJO69VQ>? NF63NIQyPzZ7MUe2Ny=>
HeLa MWfLbY5ie2ViQYPzZZk> MYKxNEDPxE1? M2WzeVMxKG2rbh?= NHn0VJdFVVOR NF7JeGhKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGhFSUNzIIfpeIghUUN3MDDv[kAxNjB{IN88US=> NHu3[FYyPzZ7MUe2Ny=>
RKOp21 MmO1R5l1d3SxeHnjJGF{e2G7 NYTieXhQPzJiaB?= NUf5TohwUUN3ME2xMlc3KM7:TR?= NV7GdpZOOTd4OUG3OlM>
Saos2 NU\sdYxVS3m2b4TvfIlkKEG|c3H5 NWjUNWVqPzJiaB?= M1XEW2lEPTB;Mj6zJO69VQ>? NV60WldMOTd4OUG3OlM>
SK-OV-3 NV7HT5JWS3m2b4TvfIlkKEG|c3H5 MYm3NkBp NGq4XHVKSzVyPUKuNkDPxE1? MkjRNVc3QTF5NkO=
U87MG NFXhO5JEgXSxdH;4bYMhSXO|YYm= MXy3NkBp NVvDN2FOUUN3ME2xNUDPxE1? M1yxfVE4PjlzN{[z
NUGC3 M1zLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPOOUDPxE1? M4PVbVI1KGh? NV3G[2dIT0l3ME2yMlc6KM7:TR?= M4fIWVE4QTB2OESz
CCD1059SK MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX1OZFKSzVyPUSzMlUh|ryP MmK2NVgzPDd3NUS=
HepG2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\wTWM2OD1yLkCwNFYh|ryP M1Tk[FE5OjR5NUW0
HT1080 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fkPGlEPTB;MD6wNFI1KM7:TR?= NVTQW5RFOTh{NEe1OVQ>
SKBR3 NV;FT5lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfPOGs1UUN3ME2wMlgh|ryP MnXNNVgzPDd3NUS=
SNB78 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\0c5NDTUN3ME2xOkDPxE1? NHzmXHgyQDJ2N{W1OC=>
SQ20B M4i5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLvXlVKSzVyPUOg{txO MWGxPFI1PzV3NB?=
St4 M2XPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvFR|UxRTVwMjFOwG0> NYPmfZh{OTh{NEe1OVQ>
MCF7 MnrTSpVv[3Srb36gRZN{[Xl? M2jZeFExKM7:TR?= NFnIcWk5KGh? MVLEUXNQ M2LGWmlv\HWldHnvckBw\iC2dXL1cIlvKGi7cHXyZYNmfHmuYYTpc44> NWPZNoJuOTh{NkmyNlY>
HEK293 MnLhT4lv[XOnIFHzd4F6 NHnVO|QyKGh? MWLEUXNQ MVvJcohq[mm2aX;uJI9nKEiGQVOxJJdqfGhiSVO1NEBw\iByLkCzJO69VQ>? M3zCeVE5OzB6NU[z
HEK293 MUjLbY5ie2ViQYPzZZk> NFyxOlMyKGh? NVrY[WRwTE2VTx?= MoTGTY5pcWKrdHnvckBw\iCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6wOVch|ryP MoD3NVg{ODh3NkO=
G401 M2XPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHpfFZ4PzJiaB?= NEf5XnRFVVOR MmjPTWM2OD1zIN88US=> NUKxXYVkOTh|N{CzO|M>
HeLa Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[3NkBp M1jrUWROW09? M1Hq[WlEPTB;MD60OkDPxE1? MkPDNVg{PzB|N{O=
Human renal epithelial cell M4Lqb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljFO|IhcA>? M{TrSmROW09? M1\IcWlEPTB;MUSg{txO M{\RTlE5OzdyM{ez
U937 NIDjT2RHfW6ldHnvckBCe3OjeR?= NGi1TlY2KM7:TR?= NVLGVml3OjRiaB?= NF\Q[IJKdmS3Y4Tpc44hd2ZiaHnzeI9v\SCKNDDofZBmemGlZYT5cIF1cW:w M4npVVE5OzhzMkO4
U937 NGSyWXZHfW6ldHnvckBCe3OjeR?= M1XaVFUh|ryP MlzqNlQhcA>? NEjaXYtKdmS3Y4Tpc44hd2ZiYXzwbIEhfHWkdXzpckBpgXCncnHj[ZR6dGG2aX;u M1zVc|E5OzhzMkO4
U937 NFf2XHpHfW6ldHnvckBCe3OjeR?= NHT5b5Y2KM7:TR?= MX6yOEBp MVrJcoR2[3Srb36gc4YheDJzIHX4dJJme3Orb36= M4LibVE5OzhzMkO4
U937 MnTESpVv[3Srb36gRZN{[Xl? NIjOOGk2KM7:TR?= NHrKNo0zPCCq MV3JcoR2[3Srb36gc4Yh[XCxcITvd4l{ NXT4doQxOTh|OEGyN|g>
U937 NXTGN4lmTnWwY4Tpc44hSXO|YYm= M1HkPVUh|ryP M{nw[FI1KGh? NF\oWYlKdmS3Y4Tpc44hd2ZiZ4LhcpVtd2O7dHnjJIRq\m[ncnXueIlifGmxbh?= M4nNVFE5OzhzMkO4
U937 MXTLbY5ie2ViQYPzZZk> NH\FNWU2KM7:TR?= MkDSNlQhcA>? NGLxZmVKdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOx NH;NTmsyQDN6MUKzPC=>
U937 NF\mWItMcW6jc3WgRZN{[Xl? M1WxVVUh|ryP MnT1NlQhcA>? NHTxN3RKdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO0 NUG4TIVnOTh|OEGyN|g>
HEK-TE M1S4bWZ2dmO2aX;uJGF{e2G7 NEDrSXo2KM7:TR?= MknWOog> MnHESG1UVw>? MnO5TY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= MX[xPFQ{PDF2NB?=
HPDE6c7 NX\4VlN4S3m2b4TvfIlkKEG|c3H5 M2fVO|UxKM7:TR?= NVftfnJtPzJiaB?= MkfVSG1UVw>? NGXG[5ZKSzVyPUGuN{DPxE1? Ml\DNVg1QTR2NkO=
Human microvascular epithelial cell MYXDfZRwfG:6aXOgRZN{[Xl? MoTDOVAh|ryP MUm3NkBp NVf0T2hnTE2VTx?= MonSTWM2OD1zLkOg{txO MVyxPFQ6PDR4Mx?=
Hup T3 NVG4RVFLS3m2b4TvfIlkKEG|c3H5 MX21NEDPxE1? MlL2O|Jp NIjSdWtFVVOR M1jWWWlEPTB;MD64JO69VQ>? MoLnNVg1QTR2NkO=
Mia Paca2 NF7PeoVEgXSxdH;4bYMhSXO|YYm= MWC1NEDPxE1? MofUO|Jp M36yUGROW09? NGTLTFFKSzVyPUGuNUDPxE1? MVqxPFQ6PDR4Mx?=
Panc 04.03 NH;zWYREgXSxdH;4bYMhSXO|YYm= M3fl[|UxKM7:TR?= NHfNVHA4Omh? NYniO4VUTE2VTx?= M4HlOmlEPTB;MT6yJO69VQ>? MUixPFQ6PDR4Mx?=
SU 86.86 M33ycmN6fG:2b4jpZ{BCe3OjeR?= NYrYOYNLPTBizszN MX[3Nog> MXTEUXNQ NYDORVhoUUN3ME2xMlMh|ryP NETzTnEyQDR7NES2Ny=>
HEK293 NUe1SIxHU2mwYYPlJGF{e2G7 M{PER|MhcA>? MX\Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWM3KGW6cILld5Nqd25id3n0bEBKSzVyIH;mJFAvODF7IN88US=> NE\tepAyQDV3OE[2PS=>
HeLa MYLLbY5ie2ViQYPzZZk> NUfwVmZvOiCq NH3yUFJKdmirYnn0bY9vKG:oIH71Z4xm[XJiSFTBR{B4cXSqIFnDOVAhd2ZiMD6wPFMh|ryP NV2x[5NxOTh3NUi2Olk>
RAW264.7 NInr[VVHfW6ldHnvckBCe3OjeR?= NFHZUGEzKM7:TR?= Ml;hN{42KGh? MnnrSG1UVw>? M4Gzb2FvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDpcoZm[3SnZDD3bZRpKEmFNUCgc4YhOC5zMTFOwG0> NYfUUIJMOTh4NES5Olk>
NB4 M2fTblQ5cA>? Mmq2SG1UVw>? M3TC[mlEPTB;MD62JO69VQ>? MkPNNVg4OjN|NEm=
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CAL27 M2LBdWN6fG:2b4jpZ{BCe3OjeR?= NYLKeIRIPzJiaB?= NFjN[4hEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN Mom1NlExQDB4Mkm=
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Sf21 M{\lW2tqdmG|ZTDBd5NigQ>? NGfqc5A{KGh? MYDJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= NUfXV3ZzOjFyOEC2Nlk>
SKBR3 MWjDfZRwfG:6aXOgRZN{[Xl? M{\J[|czKGh? M4jDPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= MUmyNVA5ODZ{OR?=
SKOV3 NYjQWIEyS3m2b4TvfIlkKEG|c3H5 NFPjeVM4OiCq M3;Nd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= NXLTN4plOjFyOEC2Nlk>
COR-L23 NEnEeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfMZYUyOCEQvF2= NY[xNlY{PzJiaB?= M{T0XmROW09? NYe1ZWdpT0l3ME2xMlEh|ryP NXy3N4pUOjFyOEC2OFc>
DU145 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzafncyOCEQvF2= NHTKeFc4OiCq NUTDNIc5TE2VTx?= Ml\2S2k2OD1zLkC1JO69VQ>? NYHKVpVrOjFyOEC2OFc>
LoVo NXjme242T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfNT2puOTBizszN NE\yeno4OiCq MWTEUXNQ NV\rN2NkT0l3ME2xMlch|ryP NH3Udm0zOTB6ME[0Oy=>
MCR5-SV2 NVrjR2kxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH0b2ZSOTBizszN NIrTcJM4OiCq NVe0dHZOTE2VTx?= MVvHTVUxRTJwMTFOwG0> NUTER5d4OjFyOEC2OFc>
HCT116 NFjwdm5McW6jc3WgRZN{[Xl? NIXJdmc{OCEQvF2= M3q3dVMxKGh? NFe3SJpFVVOR NH7Od41KdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBidHCqYT30eYJ2dGmwIHHj[ZR6dGG2aX;u Mn:1NlExQDB4NEe=
HCT116 M{TabGtqdmG|ZTDBd5NigQ>? MluwN|Ah|ryP MnH5N|AhcA>? Ml7kSG1UVw>? NYjpb4ZkUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u MmK5NlExQDB4NEe=
U937 MmnMT4lv[XOnIFHzd4F6 NXfsXopnPSEQvF2= M1\OUlI1KGh? MleySG1UVw>? NUn4XXZJUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= MmroNlEzQTJ2OUK=
U937 NUK0S2ZJU2mwYYPlJGF{e2G7 M2S1c|Uh|ryP MX2yOEBp M1HJS2ROW09? NFz1eFlKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi= NHLQWGIzOTJ7MkS5Ni=>
U937 MYDLbY5ie2ViQYPzZZk> NHHsOHY2KM7:TR?= NFe0WmgzPCCq MmPmSG1UVw>? MV7Jcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? M1XrfFIyOjl{NEmy
U937 NI\kfZRMcW6jc3WgRZN{[Xl? NVj5RnBbPSEQvF2= Mk\mNVUhdWmw NUHQfZNpTE2VTx?= NWPKbph4UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NELLUWQzOTJ7MkS5Ni=>
A2780 NYXtZodkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXe5OkBp MWfEUXNQ NE\XU5NKSzVyPUGuOlIh|ryP MUmyNVY{PDR|MB?=
COLO205 M4XvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LJNlk3KGh? MlHZSG1UVw>? MonyTWM2OD1{LkGyJO69VQ>? MoXlNlE3OzR2M{C=
Hep3B M2\jTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkK5OFghcA>? NU\ROZhMTE2VTx?= Ml7US2k2OD1zLkKxJO69VQ>? NWTvSGEzOjF5MUKxOFY>
GM11272 MYHGeY5kfGmxbjDBd5NigQ>? NITsd2MyODBibl2= NEPKbZk4OiCq NIT4ToZFVVOR M3uwUXJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> NVzlUGt3OjF6NEC3NVY>
CFBE41o NGC2OFNMcW6jc3WgRZN{[Xl? MV61JO69VQ>? M4O2XmROW09? MmnYSI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO M1nu[lIyQTh2OUW4
CFBE41o MVLGeY5kfGmxbjDBd5NigQ>? MUexJO69VQ>? NHTJVIozPCCq M3nIcGROW09? NV3EdnhxWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z Ml3XNlE6QDR7NUi=
DU145 M4DWZ2tqdmG|ZTDBd5NigQ>? M1;VNVIvPSEQvF2= NHS1SoEzPCCq NEOzfnFFVVOR NW\XUpBJUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? NHjrd4ozOjJ4MEG2Oi=>
DU145 MYPLbY5ie2ViQYPzZZk> NWDDS2ZxPSEQvF2= MXKyOEBp NVXkN49oTE2VTx?= M2G0V2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u M1r4c|IzOjZyMU[2
DU145 NUWzeZN{U2mwYYPlJGF{e2G7 MUO1JO69VQ>? M1\w[VI1KGh? NUiwRnptTE2VTx?= NUfo[XJGUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= NWLkXI1LOjJ{NkCxOlY>
786-0 NUOzSHpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDjRnB1Pi5{IN88US=> MmryO|IhcA>? NFL1SldFVVOR NI\mc2tIUTVyPUOuNkDPxE1? NInCemUzOjR|NU[2PS=>
A498 NXjlNWJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrUdmpbPi5{IN88US=> MnrmO|IhcA>? NFzJZoZFVVOR NULpcW9XT0l3ME2xMlYh|ryP M3XBbFIzPDN3Nk[5
A549/ATCC Ml3SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX6cGpvPi5{IN88US=> M4LXfFczKGh? NInmRW1FVVOR M2TuNmdKPTB;MT62JO69VQ>? NXjjTVNpOjJ2M{W2Olk>
ACHN M2K3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;XOk4zKM7:TR?= MV23NkBp MWLEUXNQ NWP1RY92T0l3ME2xMlMh|ryP MmnaNlI1OzV4Nkm=
BT549 M1zuOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnnXnE3NjJizszN M3TyTlczKGh? M1LuUWROW09? M2rkRmdKPTB;MT6zJO69VQ>? M37nblIzPDN3Nk[5
EKVX MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r1TFYvOiEQvF2= MnjyO|IhcA>? M2nrdWROW09? MnKzS2k2OD1zLkOg{txO NYLscW9{OjJ2M{W2Olk>
HCT15 NX\NOmQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTwOk4zKM7:TR?= NYe1W3dqPzJiaB?= NYXEVWU4TE2VTx?= Ml;zS2k2OD1{LkWg{txO M{HBT|IzPDN3Nk[5
HOP92 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P0[FYvOiEQvF2= NX7PdXBwPzJiaB?= NFjhWI9FVVOR MlLvS2k2OD12IN88US=> MmLRNlI1OzV4Nkm=
IGROV1 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nGeFYvOiEQvF2= NXnEc3ZHPzJiaB?= MnHHSG1UVw>? NUPHNph6T0l3ME2xMlMh|ryP MV:yNlQ{PTZ4OR?=
LOXIMVI NWe5fW9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWm2MlIh|ryP M365dlczKGh? MY\EUXNQ MmHJS2k2OD1zIN88US=> NWfXXmh6OjJ2M{W2Olk>
M14 NFvOWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWK2MlIh|ryP NVLSd2JXPzJiaB?= NYfQUo1qTE2VTx?= M1zjZmdKPTB;MT6zJO69VQ>? Mn;aNlI1OzV4Nkm=
MALME-3M MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWS2MlIh|ryP MkOxO|IhcA>? NIj2NW5FVVOR M1rKXWdKPTB;MD6zNkDPxE1? NInw[5MzOjR|NU[2PS=>
MCF10A MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPhSnc3NjJizszN M1LORVQ5KGh? MVLEUXNQ NILsfXhIUTVyPUmuOkDPxE1? NYfSPZluOjJ2M{W2Olk>
MDA-MB-435 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX4Ok4zKM7:TR?= NGP1cHY4OiCq Mmn6SG1UVw>? NUTESGlET0l3ME2wMlUh|ryP NH7VcmczOjR|NU[2PS=>
MDA-MB-468 M3PFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUi2MlIh|ryP NESyW3Q4OiCq NYHOWnBjTE2VTx?= NUTRZm5kT0l3ME2wMlY{KM7:TR?= MnrRNlI1OzV4Nkm=
MOLT4 NGLSOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rDeVYvOiEQvF2= NYn3W41CPzJiaB?= NFrGPYZFVVOR MVHHTVUxRTBwNDFOwG0> MkSzNlI1OzV4Nkm=
NCI-ADR-RES NWPQe|Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3pOk4zKM7:TR?= M2i0SVczKGh? M4LmVmROW09? NHH2cVlIUTVyPUCuNVYh|ryP Mmr0NlI1OzV4Nkm=
NCI-H23 M1\WUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1joZlYvOiEQvF2= NILiSY84OiCq NI\a[FJFVVOR M3PWbmdKPTB;MTFOwG0> NVzJPHFNOjJ2M{W2Olk>
NCI-H322M M1T5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG5SFQ3NjJizszN MUW3NkBp Ml\BSG1UVw>? NUjPTFZnT0l3ME2wMlc6KM7:TR?= MkGwNlI1OzV4Nkm=
NCI-H460 NEe2boFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MneyOk4zKM7:TR?= NIfiZ5k4OiCq MWXEUXNQ MlW3S2k2OD1yLke5JO69VQ>? NFTUdIEzOjR|NU[2PS=>
NCI-H522 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH33TII3NjJizszN NIjMSW04OiCq MlnHSG1UVw>? NV3MeJBmT0l3ME2wMlUh|ryP M1vBOFIzPDN3Nk[5
OVCAR3 NVHvcnlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXpOk4zKM7:TR?= NHq5ToQ4OiCq NVLOeo9YTE2VTx?= NYjtOlUyT0l3ME2xMlMh|ryP NXfhR|RDOjJ2M{W2Olk>
OVCAR4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fO[lYvOiEQvF2= NV;jNHl2PzJiaB?= M33sbmROW09? M3XMWGdKPTB;NDFOwG0> NXLT[WNUOjJ2M{W2Olk>
OVCAR5 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWi2MlIh|ryP NFrNbGE4OiCq MmLCSG1UVw>? M1i0eGdKPTB;MD63PUDPxE1? Mmj1NlI1OzV4Nkm=
OVCAR8 M2fm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHEVoxYPi5{IN88US=> NEKwe244OiCq MmHQSG1UVw>? M3jyN2dKPTB;MD61JO69VQ>? NIi4RVMzOjR|NU[2PS=>
RXF393 NGqzb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHTbIY3NjJizszN NITadVQ4OiCq NGTGS45FVVOR MVzHTVUxRTFwMzFOwG0> MYKyNlQ{PTZ4OR?=
SF268 NFLUTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT5Ok4zKM7:TR?= MVO3NkBp NUfYRWpkTE2VTx?= NEXIcZhIUTVyPUGuOkDPxE1? MlfuNlI1OzV4Nkm=
SF295 NGTEUYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjEeFRqPi5{IN88US=> NXTGdJdlPzJiaB?= M33nXGROW09? Mnj0S2k2OD1zLk[g{txO MWmyNlQ{PTZ4OR?=
SF539 NYTjUZN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13qZlYvOiEQvF2= MX:3NkBp MVPEUXNQ M1;KdmdKPTB;MjFOwG0> MYKyNlQ{PTZ4OR?=
SK-MEL-2 M3nMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWK2MlIh|ryP M4DCUVczKGh? MVfEUXNQ MoL6S2k2OD1zLkOg{txO MVqyNlQ{PTZ4OR?=
SK-MEL-28 NGnCNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrNOk4zKM7:TR?= M{nDbVczKGh? MYHEUXNQ MUfHTVUxRTFizszN NW[2Uo5TOjJ2M{W2Olk>
SK-MEL-5 NUTQWFhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjiOk4zKM7:TR?= MYO3NkBp MXXEUXNQ NGn0XVZIUTVyPUCuOlMh|ryP NHzCPFAzOjR|NU[2PS=>
SKOV3 MnHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXWe4xYPi5{IN88US=> MnXxO|IhcA>? NI\we4RFVVOR MUfHTVUxRTFizszN NIHrT28zOjR|NU[2PS=>
SN12C MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TudFYvOiEQvF2= MXS3NkBp M2\5TmROW09? NVHwUYdkT0l3ME2yJO69VQ>? MVmyNlQ{PTZ4OR?=
SNB19 NX3lVWVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\tOk4zKM7:TR?= MXy3NkBp NEDRUHdFVVOR MmPsS2k2OD1yLk[zJO69VQ>? M1HpSlIzPDN3Nk[5
SNB75 M{e1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLFNXY3NjJizszN NUnnXVFkPzJiaB?= Mnj2SG1UVw>? NFvEUmlIUTVyPUCuO|kh|ryP MnjwNlI1OzV4Nkm=
SR NFnTXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnCOk4zKM7:TR?= MXW3NkBp NYPYN2ZjTE2VTx?= MWDHTVUxRTBwNDFOwG0> MXqyNlQ{PTZ4OR?=
T47D NITWXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfqc283NjJizszN Mk[3O|IhcA>? M1\Nb2ROW09? MknlS2k2OD1yLkWg{txO NFm2XWYzOjR|NU[2PS=>
TK10 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmThOk4zKM7:TR?= MWq3NkBp Mn7BSG1UVw>? MYLHTVUxRTBwNkOg{txO M3\ZSFIzPDN3Nk[5
UACC257 NVvQR4FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnqbppoPi5{IN88US=> MlnmO|IhcA>? MmrFSG1UVw>? MWHHTVUxRTBwNTFOwG0> M{\1WlIzPDN3Nk[5
UACC62 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nmO|YvOiEQvF2= MVm3NkBp M1ztO2ROW09? MVjHTVUxRTBwNDFOwG0> MU[yNlQ{PTZ4OR?=
UO31 NYPSUXYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjLS5c3NjJizszN NHHlNnk4OiCq MUHEUXNQ MoW0S2k2OD1yLkWg{txO NXP1[JM2OjJ2M{W2Olk>
Hep3B MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P3Z|Q5KGh? NXTofGgxTE2VTx?= MnfHS2k2OD1yLk[5JO69VQ>? MVeyNlQ{QTh4Mx?=
BE(2)-C MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SzPVczKGh? MlH2SG1UVw>? MWjJR|cxRTJizszN NFjC[JQzOjl|MkOxOi=>
Bel7402 NVy1UZlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[zW2ltPzJiaB?= Mo\aSG1UVw>? NFPiNXlIUTlyPUG3JO69VQ>? NYLLc4M3OjNyNkGzO|Y>
Bel7404 M33rbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnqS215PzJiaB?= NFXPOG1FVVOR NFrkSplIUTlyPUG4JO69VQ>? MknONlMxPjF|N{[=
BGC823 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXaO|IhcA>? NVHYV2lkTE2VTx?= NUjXV4FqT0l7ME23MlUh|ryP M{TSdVI{ODZzM{e2
MGC803 MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXwOZk4OiCq M2e4UmROW09? MYfHTVkxRTFyLkig{txO NHnLTZozOzB4MUO3Oi=>
SGC7901 NHPNZ2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVu3NkBp MoCwSG1UVw>? NYXWR2V[T0l7ME25MlQh|ryP M{TqVVI{ODZzM{e2
SKHEP1 NX;a[2xST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYK3NkBp MlXrSG1UVw>? MmqyS2k6OD1zNzFOwG0> NVv3Nm9HOjNyNkGzO|Y>
SMMC7721 NFnqSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm2[2h4PzJiaB?= NG\0fnFFVVOR NFTC[ZlIUTlyPUKwJO69VQ>? M3L2OlI{ODZzM{e2
NUGC3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYexNEDPxE1? NUDVO|dsT0l;Mj65OEDPxE1? M1mxTlI{OTZ|M{Oy
A2780 CisR M2XsV2tqdmG|ZTDBd5NigQ>? NXfs[Gc1OThiaB?= NEjmbGdKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP M3LDSlI{OjV{NkCz
CAL27 sens NXLveWx7U2mwYYPlJGF{e2G7 MWixPEBp NG[zbHVKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Yh|ryP NYfKc5JmOjN{NUK2NFM>
CAL27 CisR NIDkXWtMcW6jc3WgRZN{[Xl? MV:xPEBp Mn\RTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NXzQO5pKOjN{NUK2NFM>
KYSE-510 CisR NYPNTJJrU2mwYYPlJGF{e2G7 NEXne5YyQCCq M1TWcmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? M4jJ[FI{OjV{NkCz
KYSE-510 sens NYLaTnlZU2mwYYPlJGF{e2G7 NYrQUZhDOThiaB?= NF7L[GRKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? MUmyN|I2OjZyMx?=
MDA-MB-231 sens MlzpT4lv[XOnIFHzd4F6 NGHEdnAyQCCq M3i4bGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MUmyN|I2OjZyMx?=
MDA-MB-231 CisR MX3LbY5ie2ViQYPzZZk> M3P3NlE5KGh? M3\UZmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NUXzWosxOjN{NUK2NFM>
ES2 NYTWR|g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV60PEBp NXK5XIZVTE2VTx?= NIjNfIpKSzVyPUGyMlch|ryP NFnvfXczOzR7M{S0PS=>
MDA-MB-231 NFXEem1McW6jc3WgRZN{[Xl? MYWxNEDPxE1? NF[ySZg{OCCvaX6= MVHEUXNQ MULJcohq[mm2aX;uJI9nKEiGQVOyZS=> M4jJTlI{PDl|NES5
MDA-MB-231 M1LlRmtqdmG|ZTDBd5NigQ>? NWfuSpVxOSEQvF2= MoTkNlQhcA>? NGnWPG9FVVOR NETMXYtKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu NXTPb4FVOjN2OUO0OFk>
HS68 NXjlcFdqS3m2b4TvfIlkKEG|c3H5 NV\XPZpbOTBizszN MoTpO|IhcA>? NHr0WVlFVVOR M36x[2lEPTB;ND62JO69VQ>? NWj0TmpxOjN3N{C1OFI>
MEF M{LwbmN6fG:2b4jpZ{BCe3OjeR?= MVmxNEDPxE1? M1frT|czKGh? NWfGUnJYTE2VTx?= NGXFUVdKSzVyPUSuOEDPxE1? MWqyN|U4ODV2Mh?=
BGC823 NEPUclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXFc5FpTE2VTx?= NEfSTodIUTVyPUOuNFkh|ryP M1PwWVI{PjBzN{C2
High5 MVjLbY5ie2ViQYPzZZk> NXL5[pBoOjRiaB?= MlTwTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? NF;HcI4zOzZyMkWyNy=>
High5 MYXLbY5ie2ViQYPzZZk> M4rEPFI1KGh? M{PM[mlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP M2TvdVI{PjB{NUKz
High5 NYLCeI5nU2mwYYPlJGF{e2G7 MXeyOEBp M4\mWWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP MXqyN|YxOjV{Mx?=
A549 NWr5V2l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTVcml[TE2VTx?= MYDJR|UxRTFwMEe5JO69VQ>? MX2yN|Y1PDJzMB?=
HCT116 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknXSG1UVw>? MVvJR|UxRTBwN{W3JO69VQ>? NHv1UIUzOzZ2NEKxNC=>
K562 NHvmTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O2RmROW09? Mlz6TWM2OD1yLk[0OUDPxE1? NFXjW|YzOzZ2NEKxNC=>
GBC-SD NUHDWGIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDKWmc2KM7:TR?= MoDzO|IhcA>? MkHrSG1UVw>? MXTJR|UxRTF2Lkig{txO M3\vRVI{PzB5Mk[w
HGC27 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXG1JO69VQ>? MVq3NkBp M3HEXWROW09? MWDJR|UxRTVwNDFOwG0> Mn7ENlM4ODd{NkC=
HL60 NGn4W4VMcW6jc3WgRZN{[Xl? M2PESVUh|ryP NGr3cnIzPCCq NH30cYFFVVOR MlfTTY5pcWKrdHnvckBw\iCKRFHD MoTYNlM4ODd{NkC=
Vero M3faRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWm3NkBp NVrnT4syTE2VTx?= MYjJR|UxRTBwOTFOwG0> NX3Nd|ZCOjN5OE[0OVI>
NCI60 M37PTmN6fG:2b4jpZ{BCe3OjeR?= MmDiOFghcA>? NULBTHZUTE2VTx?= MU\HTV0xNjV|IN88US=> NIfjOXIzPDBzNUOyOy=>
SW620 Mm[5R5l1d3SxeHnjJGF{e2G7 NY\yVGhvPDhiaB?= NVH3OFZGTE2VTx?= M3nqU2dKRTBwNUSg{txO NXjMT49yOjRyMUWzNlc>
U251 MXrDfZRwfG:6aXOgRZN{[Xl? Mn\TOFghcA>? NIXkcJJFVVOR NGLuXmdIUT1zLkWzJO69VQ>? M1\5U|I1ODF3M{K3
KM12 MVXDfZRwfG:6aXOgRZN{[Xl? MlPyOFghcA>? NXT4c5BJTE2VTx?= MUnHTV0yNjh6IN88US=> M{LtdVI1ODF3M{K3
Hs578T NEfMcHVEgXSxdH;4bYMhSXO|YYm= M3LpOVQ5KGh? NWHsT4hJTE2VTx?= MX7HTV01Njh|IN88US=> M{fSd|I1ODF3M{K3
MDA-MB-231 NFP6eY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK2Ums4PDhiaB?= MWfJR|UxRTBwMU[g{txO M1zyclI1ODl3MEG2
MCF7 MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13zflQ5KGh? MUTHTV0xNjR3IN88US=> MlnHNlQyOTl3NUW=
MDA-MB-435 NIrMVo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;GVVQ5KGh? MVnHTV0xNjh6IN88US=> NHPwfmszPDFzOUW1OS=>
AsPC1 NYTxNFBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4CyTFMxKM7:TR?= M2H4dVQ5KGh? M{H3ZWROW09? NETCfnRKSzVyPUOuOlYh|ryP MVSyOFE5PTN5OB?=
Jurkat E6.1 NEO3eodMcW6jc3WgRZN{[Xl? NFrwUlMzKGh? MUTEUXNQ MnmwTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? NXHtW3JpOjR{NkG4OlI>
KG1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzLdmlLPDhiaB?= Mo[3TWM2OD1zLkG1JO69VQ>? Moi4NlQ2OjVyMEO=
HEL NVLV[oxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfVN5A1QCCq M131SmROW09? NH[3d5ZKSzVyPUCuOFkh|ryP NUnDe4VrOjR4OUSwOVU>
HSC3 NHq1d3NEgXSxdH;4bYMhSXO|YYm= NF25UpAyOiCq NFLNUIVFVVOR NWXlUY1bUUN3ME2wMlcyKM7:TR?= NUjFVJZ3OjR5Nk[1OlA>
HT-29 MUfDfZRwfG:6aXOgRZN{[Xl? MkTMNVIhcA>? MkS4SG1UVw>? M{Dwe2lEPTB;MD63NkDPxE1? NW[w[nROOjR5Nk[1OlA>
KB MWHDfZRwfG:6aXOgRZN{[Xl? NXPQcnRDOTJiaB?= NFzkSFZFVVOR MY\JR|UxRTBwN{Wg{txO NVPGNolwOjR5Nk[1OlA>
H460 NULYN|NmS3m2b4TvfIlkKEG|c3H5 NGTRPZYyOiCq MofKSG1UVw>? MYHJR|UxRTBwOEKg{txO MoDONlQ4PjZ3NkC=
MONE1 NITUbJREgXSxdH;4bYMhSXO|YYm= MVqxNkBp Mm\vSG1UVw>? NFHpRWtKSzVyPUGuNVgh|ryP MXWyOFc3PjV4MB?=
MKN45 MlzrR5l1d3SxeHnjJGF{e2G7 NXriOGU{OTJiaB?= M3\FR2ROW09? MmDMTWM2OD1zLkK1JO69VQ>? NXz5cI5IOjR5Nk[1OlA>
TSGH Ml;lR5l1d3SxeHnjJGF{e2G7 MWSxNkBp Mk\ISG1UVw>? NFXGclNKSzVyPUKuNFkh|ryP NE\QSHAzPDd4NkW2NC=>
HL60 M3;IVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPWW29EPzJiaB?= M3r6VWROW09? M{DqfWdKPTB;MD65N{DPxE1? MVSyOFkxODVyMB?=
HEK293 NHHhdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3naR|czKGh? NYXDNog4TE2VTx?= NFryWmJIUTVyPUGzJO69VQ>? NILlUm8zPDlyMEWwNC=>
Jurkat MWLDfZRwfG:6aXOgRZN{[Xl? NEjjUngyODBizszN Mmj5O|IhcA>? NX[5[IV7T0l3ME2wMlkh|ryP NGnZdG4zPDlyMEe0Ny=>
GM15850 NITxT41McW6jc3WgRZN{[Xl? M4LHXlIvPSEQvF2= MlroPVYhcA>? MnLLSG1UVw>? NVq2XI9E\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDF2IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NGrXRnIyPjl{MUO2Oy=>
GM15850 NVP4[|JGU2mwYYPlJGF{e2G7 MUmyMlUh|ryP MkTzPVYhcA>? NWDGWoU6TE2VTx?= MVTkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Mm\ONVY6OjF|Nke=
GM15850 MV7LbY5ie2ViQYPzZZk> M{HJbFIvPSEQvF2= MVy5OkBp Mnv0SG1UVw>? NVno[HhM\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NV3YVINmOTZ7MkGzOlc>
GM15850 NH\KOIpMcW6jc3WgRZN{[Xl? MnuwNk42KM7:TR?= MUG5OkBp NXrj[|hVTE2VTx?= Mojm[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MUCxOlkzOTN4Nx?=
GM15850 MoPhT4lv[XOnIFHzd4F6 M3\UUFIvPSEQvF2= MVy5OkBp NH3tZo9FVVOR NYnPTFFI\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDhiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MYCxOlkzOTN4Nx?=
GM15850 NGPyTYxMcW6jc3WgRZN{[Xl? MlW0Nk42KM7:TR?= M1jtUVk3KGh? M1jIbGROW09? NXzlW2pQ\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF4IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M{Djc|E3QTJzM{[3
GM15850 Mo\4SpVv[3Srb36gRZN{[Xl? NUfsWmRFPSEQvF2= M2fQelEzKGh? NEHSZWNFVVOR MXLoZZMhdm9iZX\m[YN1KG:wIF\YUkBuWk6DIHX4dJJme3Orb36= MXmxOlkzOTN4Nx?=
U937 MVTLbY5ie2ViQYPzZZk> MkXrOUDPxE1? MmrONlQhcA>? NV;nS2ZjTE2VTx?= MlS5bIF{KG6xIHXm[oVkfCCxbjDhcJBp[SC2dXL1cIlvKGGlZYT5cIF1cW:w MkDpNVc1PDd5NUC=
U937 MXLLbY5ie2ViQYPzZZk> M2\jWVEh|ryP MXuyOEBp M2DkPGROW09? M4LuN4hieyCwbzDl[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= MojqNVc1PDd5NUC=
PANC1 MoP2SpVv[3Srb36gRZN{[Xl? M162eVEh|ryP NGfkWXQzPCCq M4XyO4Rw\XNibn;0JIlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NYGyeJhrOTd3OEi3OFQ>
PANC1 M3\yTmZ2dmO2aX;uJGF{e2G7 NI\ocY4yKM7:TR?= NFT6VFQ1QCBiaB?= MYPkc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= MmHqNVc2QDh5NES=
Caco-2 NWTnRpZVTnWwY4Tpc44hSXO|YYm= MkLMOUDPxE1? MmC2NlQhcA>? MYnEUXNQ MWTkc4V{KG6xdDDpcoR2[2ViUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> Ml64NlAyPDN6NEC=
SCC4 M1TybmZ2dmO2aX;uJGF{e2G7 Mmn0NUDPxE1? M{HnZ|ExKG2rbh?= M4nwS2ROW09? MULoZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? NEm1fJYzODR3MkKyOS=>
A549 MoTMSpVv[3Srb36gRZN{[Xl? NXvJV2p5PSEQvF2= M4LlW|MhcA>? MmfmSG1UVw>? M1T5eYRw\XNibn;0JIlv\HWlZTDheZRweGijZ4mgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzTWk> MUWyNFg2PTJyOB?=
HCT116 Mnf6T4lv[XOnIFHzd4F6 MkHtNE4{KM7:TR?= NV7UeWxtOzBiaB?= NYnTTphyTE2VTx?= M13qb4Rw\XNibn;0JIlvcGmkaYSgTGRCSzFiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGirc4TvcoUhUDONOTDhZ4V1gWyjdHnvci=> NHrNOVEzOTB6ME[0Oy=>
HepG2 NVrVO2FUTnWwY4Tpc44hSXO|YYm= M1HVV|ExKM7:TR?= NF3nXXczPCCq M4LIU2ROW09? NUDEdYFj\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCqeYDldoFk\XS7bHH0bY9vKG:oIIC1Ny=> MVuyNVU1QDV6Mh?=
GM11272 MonGSpVv[3Srb36gRZN{[Xl? MXOwMlEh|ryP MmC5O|IhcA>? MXTEUXNQ NXu4dmR6\G:nczDuc5QhemWjY4TpeoF1\SCPZVPwNkBufXSjboSg[ZhxemW|c3nvci=> NEjLWXkzOTh2MEexOi=>
MDA-MB-231 NEW1VnlMcW6jc3WgRZN{[Xl? MmLHNVAh|ryP M1XPWlUhdWmw NVPxWHR1TE2VTx?= M1zRcIRw\XNibn;0JIlvcGmkaYSgTGRCSzKj M3zxRVI{PDl|NES5
MDA-MB-231 NYfMRpYyU2mwYYPlJGF{e2G7 NUTSfVB4OSEQvF2= MnTpNlQhcA>? MY\EUXNQ M4fB[YRw\XNibn;0JIlvcGmkaYSgTGRCSzZiYYPz[ZN{\WRiYYOgZYNmfHmuYYTpc44hdGW4ZXzzJI9nKHS3YoXsbY4> MmfwNlM1QTN2NEm=
K562 M33IVGtqdmG|ZTDBd5NigQ>? MkPY[I9meyCwb4SgbY5pcWKrdDDISGFE M2jRZ|I{PTlzMUGx
Jurkat NV;aN25wS3m2b4TvfIlkKEG|c3H5 NUPCV4dOOjBizszN NGDVWpc4OiCq MXzEUXNQ M37S[45wKGO7dH;0c5hq[2m2eTDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvci=> NW\pZY9{OjR|MESzOFg>
HCT116 MWrBdI9xfG:|aYOgRZN{[Xl? Mn\kN{DPxE1? M3LOZVI1KGh? NUP2XnhwTE2VTx?= M3vrVYRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icEWzJJBzd3SnaX6gcIV3\Wx? NUewbYhQOjR5Nk[1OlA>
KASUMI-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTl7LkG3JI5O MWjTRW5ITVJ?
KARPAS-45 Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\UeFJ7UUN3ME2xO|MvQDlibl2= MnHnV2FPT0WU
BHT-101 NILuNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;WTWM2OD1{NESuNVghdk1? MYPTRW5ITVJ?
H9 NXHCcFY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvkTWM2OD1{NUWuNFQhdk1? MVHTRW5ITVJ?
PA-1 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ6Nj6yOkBvVQ>? NGDNTHZUSU6JRWK=
NEC8 NGjnUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjWUYhKSzVyPUK4PU4{QCCwTR?= M2jmWHNCVkeHUh?=
MHH-PREB-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ7ND61N{BvVQ>? MnX5V2FPT0WU
NB7 M4nLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHNTWM2OD1|NEWuO|Qhdk1? NEnKNlRUSU6JRWK=
A3-KAW NIjBe29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRyMD61PUBvVQ>? MXjTRW5ITVJ?
NB69 NYTufGJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRzMT63NUBvVQ>? NVzQOm9WW0GQR1XS
EoL-1-cell MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTR3NEK1JI5O MYXTRW5ITVJ?
CHP-212 NGGxbZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm[zTWM2OD12NUeuOVMhdk1? NUPOfGx[W0GQR1XS
C2BBe1 NEjTOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR5Mj6xPUBvVQ>? NWfTXFdMW0GQR1XS
697 NIH1TZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\NSGlEPTB;NEezMlQyKG6P M{ntRnNCVkeHUh?=
BCPAP NFTPSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTVyMT60NkBvVQ>? MYfTRW5ITVJ?
L-363 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7oNphKSzVyPUWwN{4yKG6P MVLTRW5ITVJ?
ES8 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;4dnpKSzVyPUWyN{42OyCwTR?= MYTTRW5ITVJ?
BE-13 M{W5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTV{Nj65OkBvVQ>? M3H1cnNCVkeHUh?=
CTB-1 NIDTVohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLkTWM2OD13M{euPVIhdk1? MmnHV2FPT0WU
HD-MY-Z M{fEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDsUJJsUUN3ME21N|gvOTNibl2= M2nZSnNCVkeHUh?=
NKM-1 NVTZO4NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3UdFdKSzVyPUW0OE4zPyCwTR?= NEfDbJZUSU6JRWK=
NCI-H720 MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTV4MD6xPEBvVQ>? M2\KNHNCVkeHUh?=
KY821 M{LuPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnjeodtUUN3ME21OlMvOjVibl2= MVnTRW5ITVJ?
OVCAR-5 M2PrVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv2TWM2OD13N{[uNVEhdk1? M17J[XNCVkeHUh?=
CTV-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnPWmtbUUN3ME21PFEvPTZibl2= M2C4cXNCVkeHUh?=
P12-ICHIKAWA NHzzWmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTV7Nj61NUBvVQ>? NHXhWpVUSU6JRWK=
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JVM-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTFwOEW0OVEh|ryP MkLvV2FPT0WU
OS-RC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULMUnNZUUN3ME2xMlg4OTVzIN88US=> MWjTRW5ITVJ?
COLO-320-HSR NX7GbGVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXPW4JTUUN3ME2xMlg5OTl5IN88US=> MY\TRW5ITVJ?
HN MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYW0R3Y2UUN3ME2xMlg5PzJ3IN88US=> M3faNnNCVkeHUh?=
HT MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXLVmxKSzVyPUGuPFg6PDdizszN NWD1c4JDW0GQR1XS
LoVo NYnIdlByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj4TWM2OD1zLki5PFEh|ryP NXjCSZh1W0GQR1XS
CGTH-W-1 M3TQ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXS[YZKSzVyPUGuPFk6PDZizszN MmjCV2FPT0WU
NB6 NFvscWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljGTWM2OD1zLkmxNlk5KM7:TR?= MmLIV2FPT0WU
EW-22 M2PwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LJZ2lEPTB;MT65Nlg5PyEQvF2= NXnBeoRuW0GQR1XS
ES6 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r4R2lEPTB;MT65N|Y{OSEQvF2= M1nvVnNCVkeHUh?=
SCC-15 NXm5NpY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTHTWM2OD1zLkmzPFE6KM7:TR?= NE\tco9USU6JRWK=
HL-60 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwOUO5NFIh|ryP M1zoZ3NCVkeHUh?=
human HOP-92 NX7EdGtWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLGTWM2OD1zLkm0NFY2KM7:TR?= MUjTRW5ITVJ?
SW626 M{H2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHi5THpKSzVyPUGuPVQ5QTlizszN MnrxV2FPT0WU
HEC-1 M2T2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD5TWM2OD1zLkm1N|Yh|ryP NVPjcJlGW0GQR1XS
LB2241-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTDTWM2OD1zLkm4NlMyKM7:TR?= NUjINYNOW0GQR1XS
Ramos-2G6-4C10 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT4e|JKSzVyPUGuPVk1QTNizszN NHH5NW5USU6JRWK=
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NCI-H446 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrZbWhKSzVyPUKuNFQ2QTlizszN MYrTRW5ITVJ?
SBC-5 Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;OOZZyUUN3ME2yMlA3OTR5IN88US=> MlXtV2FPT0WU
HOS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDRN|VlUUN3ME2yMlA4PjV|IN88US=> MXHTRW5ITVJ?
K5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr5TWM2OD1{LkC3PFEyKM7:TR?= Mn;rV2FPT0WU
HLE MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr3Rm5KSzVyPUKuNFg2OjlizszN MYXTRW5ITVJ?
HSC-2 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3wTWM2OD1{LkGyPFk5KM7:TR?= NXfOR25mW0GQR1XS
LCLC-97TM1 M2DTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknsTWM2OD1{LkG0OVg{KM7:TR?= MXHTRW5ITVJ?
DMS-273 NEnaOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjVb5FzUUN3ME2yMlE1QDN5IN88US=> M2LE[XNCVkeHUh?=
TE-8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO1eWVnUUN3ME2yMlE2PzZ3IN88US=> MkXiV2FPT0WU
DSH1 NWKzcYtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT1[JJKSzVyPUKuNVY{QThizszN MVHTRW5ITVJ?
CAL-51 M1\JPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLJTWM2OD1{LkG2Olk6KM7:TR?= M13ud3NCVkeHUh?=
IST-SL1 NHXJR49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVWx[4d2UUN3ME2yMlE3QDR2IN88US=> MXXTRW5ITVJ?
GCT MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXUdJNKSzVyPUKuNVc4PyEQvF2= M17wW3NCVkeHUh?=
SW948 M{Tn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwMUi0OVYh|ryP M3XlWXNCVkeHUh?=
NOMO-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJwMUmzNVch|ryP NVfZVm41W0GQR1XS
C8166 M2K5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKySWh1UUN3ME2yMlIyOzN2IN88US=> M2P2[XNCVkeHUh?=
OC-314 NF2z[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjkWZloUUN3ME2yMlI{OjV7IN88US=> NUP5S4xGW0GQR1XS
CAL-39 M4rxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDu[WFKSzVyPUKuNlM3OjZizszN NV;2[3J{W0GQR1XS
MDA-MB-453 NX3G[IJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELKNoZKSzVyPUKuNlQzPzVizszN MULTRW5ITVJ?
A673 NIDkZ4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\VTWM2OD1{LkK1PFYzKM7:TR?= M1vJd3NCVkeHUh?=
HTC-C3 M332eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJwMk[4OUDPxE1? NYPCXoc6W0GQR1XS
NCI-H1666 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rsbGlEPTB;Mj6yPFEyOSEQvF2= MVjTRW5ITVJ?
PSN1 MkOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;aSXhKSzVyPUKuNlg6OTNizszN MVLTRW5ITVJ?
GI-1 NX7PVHc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSwTWM2OD1{LkOwOVQ{KM7:TR?= NVixSJh[W0GQR1XS
HuH-7 M2\5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJwM{C2N|ch|ryP NYGwVYFCW0GQR1XS
JAR MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmW5TWM2OD1{LkOxPVg4KM7:TR?= NEPSPZBUSU6JRWK=
5637 M4TVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXmW|lmUUN3ME2yMlMzOTJ7IN88US=> NGrKcHBUSU6JRWK=
GB-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;JWGlEPTB;Mj6zNlM{PSEQvF2= MY\TRW5ITVJ?
KP-N-YS NFuy[nhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXsPW5KSzVyPUKuN|I3OTVizszN MWPTRW5ITVJ?
OAW-42 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q0TGlEPTB;Mj6zN|QyPiEQvF2= NWr0NXY1W0GQR1XS
8-MG-BA NV3QSm1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwM{O5NFYh|ryP NX33S3ZGW0GQR1XS
RH-18 NEe0XYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPDUZlKSzVyPUKuN|UxOjJizszN NF[5W2xUSU6JRWK=
NCI-H1155 NYHOW|liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zES2lEPTB;Mj6zOlczPSEQvF2= NI\MVFhUSU6JRWK=
NB17 NI\oTFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3aOnZRUUN3ME2yMlM5OjR|IN88US=> NXixdoVuW0GQR1XS
NCI-H1437 MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO5TWM2OD1{LkSxPFc{KM7:TR?= NIXrXVFUSU6JRWK=
SN12C NYfpN2d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;LR45KSzVyPUKuOFMzOTRizszN M4HBeHNCVkeHUh?=
HSC-3 NHPZ[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXZR2ZKSzVyPUKuOFQ2ODlizszN MUfTRW5ITVJ?
GAMG NWXBZ49nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T4c2lEPTB;Mj60OFU3OSEQvF2= MVzTRW5ITVJ?
HT-1080 M4TjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XHW2lEPTB;Mj60OFg3PCEQvF2= M3HlSXNCVkeHUh?=
A549 M33SZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJwNES4PVMh|ryP NHTZcnlUSU6JRWK=
KNS-62 NIqxV2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DHRmlEPTB;Mj60OVA3OSEQvF2= M4DKbnNCVkeHUh?=
YKG-1 M4jYRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nofWlEPTB;Mj60OVQ{PyEQvF2= M2m4XHNCVkeHUh?=
LU-134-A NIXMd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHKdpJKSzVyPUKuOFcxODhizszN M1jsWXNCVkeHUh?=
FADU MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUftNYNZUUN3ME2yMlQ4OTZ{IN88US=> NYPaV25xW0GQR1XS
TGBC11TKB M1LwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\oTWM2OD1{LkS3NVc4KM7:TR?= NUnwSWlHW0GQR1XS
HT-3 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL3Xmg4UUN3ME2yMlQ6PTN3IN88US=> M3PidHNCVkeHUh?=
NCI-H2170 M1X3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTLTGJmUUN3ME2yMlUxPTR7IN88US=> NHnYdphUSU6JRWK=
Mo-T NFLLcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLKTWM2OD1{LkWwPVI4KM7:TR?= NVv1U|dyW0GQR1XS
CCRF-CEM MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInUXVVKSzVyPUKuOVMxPDNizszN MojsV2FPT0WU
KU-19-19 NVS0[4l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwNUO1NVMh|ryP Mm\DV2FPT0WU
NCI-H1048 NEDmXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj4TWM2OD1{LkW1NFI2KM7:TR?= NGnqc2VUSU6JRWK=
KOSC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrHO2RkUUN3ME2yMlU3ODd4IN88US=> NVK3b2xMW0GQR1XS
A431 M{[0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jmVGlEPTB;Mj61OlM{PSEQvF2= MmPmV2FPT0WU
COR-L23 M{jXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO4TWM2OD1{LkW4OVY3KM7:TR?= M1j5bXNCVkeHUh?=
MKN28 M4nx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNUmwN|ch|ryP NGDyfJRUSU6JRWK=
22RV1 M{L5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe4U5BoUUN3ME2yMlU6Ojd2IN88US=> Mo\DV2FPT0WU
ABC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe2[YJqUUN3ME2yMlYxPDZizszN NWTCNItUW0GQR1XS
NCI-H2126 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK5TWM2OD1{Lk[wPVg1KM7:TR?= MUjTRW5ITVJ?
DoTc2-4510 NUTIPZpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTnU3NKSzVyPUKuOlIyQDVizszN MWjTRW5ITVJ?
SCC-4 Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPPWphJUUN3ME2yMlY{ODF{IN88US=> NXnXOVNzW0GQR1XS
NCI-H661 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTQfHR6UUN3ME2yMlY1ODh3IN88US=> MkD3V2FPT0WU
RPMI-2650 NU[wTZlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHNWo9tUUN3ME2yMlY1OTR|IN88US=> NELVW4NUSU6JRWK=
NCI-H510A MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr0RnNpUUN3ME2yMlY1PDJ4IN88US=> M3HMPXNCVkeHUh?=
BPH-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjFU3FKSzVyPUKuOlU5PSEQvF2= MUjTRW5ITVJ?
M14 NXv6RpBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\rTWM2OD1{Lk[2PVk{KM7:TR?= MU\TRW5ITVJ?
G-402 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfKOmpJUUN3ME2yMlcxPDVzIN88US=> NFHrNVZUSU6JRWK=
AsPC-1 NFHmRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\oXZBKSzVyPUKuO|EyPyEQvF2= MUHTRW5ITVJ?
NB12 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zPVWlEPTB;Mj63NVcyKM7:TR?= MV7TRW5ITVJ?
SK-HEP-1 MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHm0ZXBKSzVyPUKuO|Q{QTFizszN MkPVV2FPT0WU
U-266 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fGbWlEPTB;Mj63O|EzOSEQvF2= NV\iO3FYW0GQR1XS
AM-38 M1fDdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvKSXlKSzVyPUKuO|c{PTVizszN MlKyV2FPT0WU
PC-14 NGPUdoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LxXWlEPTB;Mj64NFUyKM7:TR?= NH[2WG1USU6JRWK=
EGI-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn5enFMUUN3ME2yMlgyPzR|IN88US=> MUnTRW5ITVJ?
LS-411N MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrxTWM2OD1{LkiyN|Mh|ryP Mn;mV2FPT0WU
BFTC-905 M3TsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHXUZJ5UUN3ME2yMlg2PTJ|IN88US=> M3XheXNCVkeHUh?=
CaR-1 NUmweVg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHJTWM2OD1{Lki2JO69VQ>? MmTPV2FPT0WU
NCI-H292 M4nJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf3UY5KSzVyPUKuPFY2QTZizszN MV7TRW5ITVJ?
8305C MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJwOE[2OFUh|ryP NUPofZk1W0GQR1XS
SNU-449 NH;BRmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXiSYRKSzVyPUKuPFkyQDJizszN Mn[0V2FPT0WU
LCLC-103H M4nkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCxUopIUUN3ME2yMlkxPDN6IN88US=> NW\mU4s4W0GQR1XS
SW1573 MlP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJwOU[wPFIh|ryP Mn3XV2FPT0WU
MLMA M4ThcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGxTWM2OD1{Lkm2O|E4KM7:TR?= NH7seHhUSU6JRWK=
NCI-H1355 MmKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17ZeGlEPTB;Mz6wNFc6PiEQvF2= MYPTRW5ITVJ?
RMG-I NIXNNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXXd2JKSzVyPUOuNFI2QTJizszN NXz2ZWx5W0GQR1XS
BB65-RCC NIXrTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjITFZvUUN3ME2zMlA{OzF2IN88US=> NI\lbXNUSU6JRWK=
PC-3 NVLtSFNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fwS2lEPTB;Mz6wN|g4PCEQvF2= M{jhcHNCVkeHUh?=
SF268 NGHSbHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TlXmlEPTB;Mz6wOFUzOyEQvF2= MY\TRW5ITVJ?
NCI-H810 Ml;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LTcGlEPTB;Mz6wOFgzOyEQvF2= NVLlOo1wW0GQR1XS
MEG-01 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TCVmlEPTB;Mz6wOlE3PCEQvF2= MmTpV2FPT0WU
SW13 MkjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjMTJByUUN3ME2zMlA4QDR5IN88US=> M3nuUHNCVkeHUh?=
RH-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzrTZNKSzVyPUOuNVAzPzhizszN M1PWRnNCVkeHUh?=
GT3TKB MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTiXnExUUN3ME2zMlEyOjh|IN88US=> M{\YNHNCVkeHUh?=
TK10 NGPjWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rPb2lEPTB;Mz6xN|czPCEQvF2= MULTRW5ITVJ?
T-24 NFvzOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnCVohKSzVyPUOuNVUxPyEQvF2= M37SXHNCVkeHUh?=
A498 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWT1ZlI{UUN3ME2zMlIxQDdzIN88US=> NYLzNm5jW0GQR1XS
GR-ST MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP2TWM2OD1|LkKyNVM6KM7:TR?= Mle3V2FPT0WU
LB2518-MEL NUH1fFVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnpXHBDUUN3ME2zMlIzOzl6IN88US=> NVH1[WFUW0GQR1XS
T47D M2LYTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;l[25MUUN3ME2zMlI{PjJ5IN88US=> NGjPSGVUSU6JRWK=
NCI-H1651 MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK5TWM2OD1|LkK0OlQ1KM7:TR?= NV7BO3RpW0GQR1XS
EC-GI-10 NWCySWVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\NOGlEPTB;Mz6yOlE2OyEQvF2= MX3TRW5ITVJ?
HT-29 M3q5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvpSHNmUUN3ME2zMlI3PjF2IN88US=> NHHVOG1USU6JRWK=
GI-ME-N NXrUfXpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGryWYdKSzVyPUOuNlk2OTFizszN MULTRW5ITVJ?
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RKO MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvIW|hLUUN3ME2zMlMxPzV5IN88US=> M4H4O3NCVkeHUh?=
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U-118-MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nmNmlEPTB;MkOuO|IyPyEQvF2= MYLTRW5ITVJ?
NCI-H596 M3:3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzpW2NKSzVyPUKzMlkxPTVizszN NEXCVFNUSU6JRWK=
MZ1-PC NV20ZoY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2Lk[3OVkh|ryP NYHQU2Q2W0GQR1XS
SW1417 NIPWRXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:yWZlKSzVyPUK1MlI1QThizszN MVnTRW5ITVJ?
NCI-H82 M{fhbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJ4LkSyPFgh|ryP M{DBXnNCVkeHUh?=
COLO-678 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP1TWM2OD1{Nz60PVE6KM7:TR?= NV\xeGxTW0GQR1XS
KURAMOCHI NEHmZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHEZ4ZKSzVyPUK4MlEzPiEQvF2= NYPVbZVlW0GQR1XS
NCI-H1650 NWm3d|N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC0TWM2OD1|MD6xPVI1KM7:TR?= NYfWbHYzW0GQR1XS
HCC1954 MmLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTNzLkO2OlYh|ryP MkPQV2FPT0WU
GAK M{\0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HwR2lEPTB;M{KuNlYyPiEQvF2= Mke5V2FPT0WU
YAPC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\PTpNKSzVyPUOzMlc3PDhizszN M3;aPHNCVkeHUh?=
NCI-H2228 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLNVotJUUN3ME2zOE4{PjB3IN88US=> MnnsV2FPT0WU
VMRC-RCZ MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvubVNKSzVyPUO2MlMxOjJizszN NGHvRldUSU6JRWK=
NMC-G1 MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnGWXhqUUN3ME2zO{4xPTJ7IN88US=> MnuyV2FPT0WU
D-336MG MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW5S3R4UUN3ME20NU45PDR{IN88US=> MmrjV2FPT0WU
UACC-62 M13WcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\S[WlEPTB;NEKuOVUxPSEQvF2= M17HVnNCVkeHUh?=
C-33-A NEH0e|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfYXlhTUUN3ME20OU4{OjV4IN88US=> NGnse|RUSU6JRWK=
HCC1937 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELoRlZKSzVyPUS3MlE6PThizszN M1PCenNCVkeHUh?=
HDLM-2 NXPqdnZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTR5LkKyPFch|ryP M4nWSXNCVkeHUh?=
NCI-H727 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluxTWM2OD12Nz6yOFUyKM7:TR?= MmjyV2FPT0WU
NY NUnaPVJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPqTWM2OD12OT6zPVA5KM7:TR?= NELQXWdUSU6JRWK=
NCI-H2291 M3P0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWr2eoVMUUN3ME20PU45OzBzIN88US=> M{DROXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Suspended Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID