Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 182 Publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NI\HdmVMcW6jc3WgRZN{[Xl? M4HCcFEhcA>? NIrDOZhFVVOR MnLwZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP M{HGOFEyQTZyNEi5
Friend leukemic cell NELj[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW1NEDPxE1? NFizeJo4OiCq NGjVcHdFVVOR MUDJR|UxRTBwOUmg{txO MoHBNVIyODl7MUO=
K562 MmfWT4lv[XOnIFHzd4F6 MXy2JIg> NYfiS2VFTE2VTx?= MlnOTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN MV:xNlQyQTN6MB?=
HT1080 M2PZbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnFO|IhcA>? MWTEUXNQ MkfUTWM2OD1{LkSg{txO M3;qNFEzOjdyMUe1
H1299 Mm\UT4lv[XOnIFHzd4F6 NX32cVhDOjBibXnu M{jtSWROW09? Ml;OTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= NEOy[5cyPDV{MUSyNi=>
H1299 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj4V4I4OiCq MX3EUXNQ MYLJR|UxRTdwMkSg{txO NVvjUndzOTR3MkG0NlI>
HeLa M2G5UmtqdmG|ZTDBd5NigQ>? M1jhZlMxKG2rbh?= MXrJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> NW\jNHVWOTV4MEO5OFk>
LOX-IMVI NI\LO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G3PFQ5KGh? NW\Yeot{UUN3ME2xMlMh|ryP MnzpNVU4OTV2N{C=
NCI-H226 NXzL[|FST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPROFghcA>? MYXJR|UxRTJwNjFOwG0> M2nHRlE2PzF3NEew
RXF-631L M1[wfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrSSFY1QCCq Mk\pTWM2OD1{IN88US=> MXmxOVcyPTR5MB?=
SNB-78 MnTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TBUVQ5KGh? M{C3eGlEPTB;MU[g{txO MkDiNVU4OTV2N{C=
St-4 NGnoNVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWX1bFFuPDhiaB?= MWnJR|UxRTVwMjFOwG0> MnfGNVU4OTV2N{C=
ARP1 M3u1XGZ2dmO2aX;uJGF{e2G7 MVGyJO69VQ>? M4PUR|YhcA>? NE\Lc2dKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> M1XzclE1PzN2OEC2
CEM NESwOHVMcW6jc3WgRZN{[Xl? MY[xJIg> M1e4ZmROW09? M1\CUmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? MYexOlQzODB4NB?=
HCT15 NHnVRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO0PEBp NHrqUHpIUTVyPUCuPFIh|ryP NEDrNXoyPjd{M{KyOy=>
NCI-H23 NV:yTog3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\DS5Z{PDhiaB?= NXPC[oxPT0l3ME2wMlkzKM7:TR?= NFrON44yPjd{M{KyOy=>
GM15850 NVu0VllPU2mwYYPlJGF{e2G7 M4fCTlIvPSEQvF2= MX:5OkBp NVWzOlFsTE2VTx?= NETQTVdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NXe3TFNUOTZ7MkGzOlc>
GM15850 NFOwU4FMcW6jc3WgRZN{[Xl? M2TQU|IvPSEQvF2= MlLOPVYhcA>? NFjjSFdFVVOR MV7Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NVXJT4I1OTZ7MkGzOlc>
GM15850 NVX5bGlrU2mwYYPlJGF{e2G7 Mlv5Nk42KM7:TR?= Ml;wPVYhcA>? MlLRSG1UVw>? MoXPTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MkDCNVY6OjF|Nke=
GM15850 M3jpPGtqdmG|ZTDBd5NigQ>? M3;IbFIvPSEQvF2= NULRN|c2QTZiaB?= M{nVSmROW09? NECxZ41KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NYHjNHRoOTZ7MkGzOlc>
GM15850 M2XKXmtqdmG|ZTDBd5NigQ>? M1TnOlIvPSEQvF2= M3jlPFk3KGh? M1y1eWROW09? M3XNOWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n Mlr1NVY6OjF|Nke=
GM15850 MkHNT4lv[XOnIFHzd4F6 MWiyMlUh|ryP NW\qSHdnQTZiaB?= MlnhSG1UVw>? NWrrNm1GUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M3TzS|E3QTJzM{[3
U937 MYTGeY5kfGmxbjDBd5NigQ>? M2Sy[FUh|ryP MYCyOEBp NXuwe3pQTE2VTx?= M1zlXmNmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? NFHWXHYyPzByNEexPC=>
H661 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDoUlJ6PDhiaB?= NXTUOHRHUUN3ME2xJO69VQ>? NVrBNY5XOTdzNUewNFk>
U937 M1OwVWZ2dmO2aX;uJGF{e2G7 M3j5SVUh|ryP NIHEZ4ozPCCq M3jTO2ROW09? MVnJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w MnHUNVc1PDd5NUC=
U937 M1G1ZWZ2dmO2aX;uJGF{e2G7 NXnxXVdvOSEQvF2= Ml;MNlQhcA>? MVvEUXNQ MYjF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= M4jQVVE4PDR5N{Ww
RAW264.7 NEOwNXhHfW6ldHnvckBCe3OjeR?= NX;Wb41TOTBizszN M2jmRlI1cA>? NWrDelFOf2G2ZYK= NELB[VdKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NYe0OnFJOTd2N{e1NVg>
RAW264.7 Mmf4SpVv[3Srb36gRZN{[Xl? NITK[mcyOCEQvF2= MWiyOIg> MX\3ZZRmeg>? MmfTTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> MUKxO|Q4PzVzOB?=
SC9 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXiWJFwPDhiaB?= NFr5d2FKSzVyPUCuOlA3KM7:TR?= NHfmV40yPzVyN{KxPS=>
ST14A NIXaR5hHfW6ldHnvckBCe3OjeR?= NF3MV3E2KG6P MknIO|IhcA>? NHeyXW1KdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v M3XlclE4PTZ3OUmz
ST14A NEDDToVHfW6ldHnvckBCe3OjeR?= MWO1JI5O MWK3NkBp MULJcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? MWexO|U3PTl7Mx?=
PANC1 NHTvW2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLHNUDPxE1? MWDJR|UxRTBwNEWg{txO MoHQNVc2QDh5NES=
PANC1 MWHGeY5kfGmxbjDBd5NigQ>? MlHNNUDPxE1? NITyW5ozPCCq NGHxS4hKdmO{ZXHz[UBqdiCyMkHXRWYyN0OLUEGg[4Vv\SCneIDy[ZN{cW:w MnvSNVc2QDh5NES=
PANC1 M4nNc2Z2dmO2aX;uJGF{e2G7 MYixJO69VQ>? NHO3RVUzPCCq Mnj0TY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= MV2xO|U5QDd2NB?=
PT45 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXzTWM2OD12IN88US=> MWOxO|U5QDd2NB?=
ACHN NF3lWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jVVFIyKGh? NVzncWZLT0l3ME2wMlY2KM7:TR?= NX;Tc|VtOTd4NkK2NFY>
PC3 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrhNlEhcA>? MlvpS2k2OD1yLkexJO69VQ>? NX;QemlVOTd4NkK2NFY>
A431 Mk\0R5l1d3SxeHnjJGF{e2G7 MVm3NkBp NUDDRlBSUUN3ME20MlIh|ryP NE[xZpkyPzZ7MUe2Ny=>
Cal27 MkD5R5l1d3SxeHnjJGF{e2G7 M{PjNlczKGh? MkTwTWM2OD1|LkKg{txO MXSxO|Y6OTd4Mx?=
CCRF-CEM NHf5WG1EgXSxdH;4bYMhSXO|YYm= M3ixSlczKGh? NHz0U5BKSzVyPUCuPEDPxE1? Mn\MNVc3QTF5NkO=
EOL1 NVu1XndoS3m2b4TvfIlkKEG|c3H5 MmHVO|IhcA>? NXL4fpJJUUN3ME2xJO69VQ>? MXGxO|Y6OTd4Mx?=
Hec-1-A NWDEe|Z7S3m2b4TvfIlkKEG|c3H5 M2myZVczKGh? MWDJR|UxRTFizszN NWnDTotTOTd4OUG3OlM>
HeLa M{K0e2tqdmG|ZTDBd5NigQ>? M2DqclExKM7:TR?= MorGN|AhdWmw NVXjVFNCTE2VTx?= MlHzTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4xOiEQvF2= NWfiSFM5OTd4OUG3OlM>
RKOp21 NIK2e|ZEgXSxdH;4bYMhSXO|YYm= MWC3NkBp NXfpWXE6UUN3ME2xMlc3KM7:TR?= M4nzN|E4PjlzN{[z
Saos2 M3;TeWN6fG:2b4jpZ{BCe3OjeR?= M4LjWlczKGh? Ml\WTWM2OD1{LkOg{txO Mm\YNVc3QTF5NkO=
SK-OV-3 M3[5TGN6fG:2b4jpZ{BCe3OjeR?= M1;iU|czKGh? NXjkN5V7UUN3ME2yMlIh|ryP MofPNVc3QTF5NkO=
U87MG MWfDfZRwfG:6aXOgRZN{[Xl? MmTjO|IhcA>? MYTJR|UxRTFzIN88US=> M4jaV|E4PjlzN{[z
NUGC3 NXXmPXhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXG1JO69VQ>? MkL5NlQhcA>? NF;3T3lIUTVyPUKuO|kh|ryP NEG5foQyPzlyNEi0Ny=>
CCD1059SK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHnTWM2OD12Mz61JO69VQ>? MlG2NVgzPDd3NUS=
HepG2 NIrsS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWn6TFRbUUN3ME2wMlAxODZizszN NYiyWpJjOTh{NEe1OVQ>
HT1080 MnjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMECyOEDPxE1? MnjmNVgzPDd3NUS=
SKBR3 NFH2ZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwODFOwG0> MlntNVgzPDd3NUS=
SNB78 NIDXdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzZN|FwTUN3ME2xOkDPxE1? NIT3VYcyQDJ2N{W1OC=>
SQ20B M2\XbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXhVFBKSzVyPUOg{txO MWexPFI1PzV3NB?=
St4 NEjGXWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjPTnNFTUN3ME21MlIh|ryP NWD5OpVyOTh{NEe1OVQ>
MCF7 MXvGeY5kfGmxbjDBd5NigQ>? MWCxNEDPxE1? MlrNPEBp M33YOGROW09? MnriTY5lfWO2aX;uJI9nKHS3YoXsbY4hcHmyZYLhZ4V1gWyjdHnvci=> NFjPelcyQDJ4OUKyOi=>
HEK293 Ml;UT4lv[XOnIFHzd4F6 NUfBOplpOSCq MYjEUXNQ NH75SWZKdmirYnn0bY9vKG:oIFjERWMyKHerdHigTWM2OCCxZjCwMlA{KM7:TR?= M3HJTVE5OzB6NU[z
HEK293 NFXyTIZMcW6jc3WgRZN{[Xl? NIf0cosyKGh? NEDQ[3FFVVOR M3flOGlvcGmkaYTpc44hd2ZiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNFU4KM7:TR?= MUSxPFMxQDV4Mx?=
G401 NWPGU2Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPqO|IhcA>? NVy5S3FMTE2VTx?= MXjJR|UxRTFizszN Mni0NVg{PzB|N{O=
HeLa MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULtZpRxPzJiaB?= MYTEUXNQ NH7TN|VKSzVyPUCuOFYh|ryP NELUNnQyQDN5MEO3Ny=>
Human renal epithelial cell MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVy3NkBp MXTEUXNQ M4m3[WlEPTB;MUSg{txO MoDvNVg{PzB|N{O=
U937 M2\heGZ2dmO2aX;uJGF{e2G7 MUi1JO69VQ>? MlnCNlQhcA>? MYrJcoR2[3Srb36gc4YhcGm|dH;u[UBJPCCqeYDldoFk\XS7bHH0bY9v MWKxPFM5OTJ|OB?=
U937 NHfwRY1HfW6ldHnvckBCe3OjeR?= MojkOUDPxE1? MlTvNlQhcA>? NXTCSIpMUW6mdXP0bY9vKG:oIHHsdIhiKHS3YoXsbY4hcHmyZYLhZ4V1gWyjdHnvci=> NEi5THgyQDN6MUKzPC=>
U937 NYG2cFB5TnWwY4Tpc44hSXO|YYm= NYLtS28yPSEQvF2= MnLBNlQhcA>? NF;JZZNKdmS3Y4Tpc44hd2ZicEKxJIV5eHKnc4Ppc44> NHPVfIcyQDN6MUKzPC=>
U937 MkDhSpVv[3Srb36gRZN{[Xl? MnzmOUDPxE1? M{\LUlI1KGh? NG\EV5VKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M4qybFE5OzhzMkO4
U937 NFH2VXNHfW6ldHnvckBCe3OjeR?= MXG1JO69VQ>? NHzjeHAzPCCq NUTWZldTUW6mdXP0bY9vKG:oIHfyZY52dG:leYTpZ{BlcW[oZYLlcpRq[XSrb36= NX\MXnhEOTh|OEGyN|g>
U937 M2i0bWtqdmG|ZTDBd5NigQ>? MmX6OUDPxE1? NGTZTWkzPCCq MnHnTY5pcWKrdHnvckBw\iCqdX3hckBJTEGFMR?= MliyNVg{QDF{M{i=
U937 NEjYXJVMcW6jc3WgRZN{[Xl? NEnUN4c2KM7:TR?= MlrZNlQhcA>? NVG1R2hHUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDOC=> MoPpNVg{QDF{M{i=
HEK-TE NIDCS3JHfW6ldHnvckBCe3OjeR?= MUi1JO69VQ>? MmHjOog> M2fGSWROW09? M2XaOGlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NHnGOVkyQDR|NEG0OC=>
HPDE6c7 NH3CSWxEgXSxdH;4bYMhSXO|YYm= MWi1NEDPxE1? MnTIO|IhcA>? MofjSG1UVw>? MXPJR|UxRTFwMzFOwG0> NHfi[oUyQDR7NES2Ny=>
Human microvascular epithelial cell M2LwNGN6fG:2b4jpZ{BCe3OjeR?= MXG1NEDPxE1? MXG3NkBp NGfHVo9FVVOR M3nMVGlEPTB;MT6zJO69VQ>? Mn7rNVg1QTR2NkO=
Hup T3 NV7xV3lzS3m2b4TvfIlkKEG|c3H5 NXGxbJVHPTBizszN NXj4V25LPzKq M3n5RWROW09? NYnB[XVRUUN3ME2wMlgh|ryP NG\Hd|EyQDR7NES2Ny=>
Mia Paca2 MWLDfZRwfG:6aXOgRZN{[Xl? M3S0U|UxKM7:TR?= MojoO|Jp NX;oSWFNTE2VTx?= MkXLTWM2OD1zLkGg{txO NFvqU|IyQDR7NES2Ny=>
Panc 04.03 Moe5R5l1d3SxeHnjJGF{e2G7 NFn3epQ2OCEQvF2= NI[zfVM4Omh? M3zGVmROW09? M{HURWlEPTB;MT6yJO69VQ>? NEP3S3gyQDR7NES2Ny=>
SU 86.86 M3jNSmN6fG:2b4jpZ{BCe3OjeR?= MVW1NEDPxE1? MU[3Nog> MoLvSG1UVw>? NU[3emIyUUN3ME2xMlMh|ryP MVmxPFQ6PDR4Mx?=
HEK293 NVexXI13U2mwYYPlJGF{e2G7 MoLZN{Bp M1XYPWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgTGRCSzZiZYjwdoV{e2mxbjD3bZRpKEmFNUCgc4YhOC5yMUmg{txO M1mzZlE5PTV6Nk[5
HeLa MlvDT4lv[XOnIFHzd4F6 MVeyJIg> NEXrNWFKdmirYnn0bY9vKG:oIH71Z4xm[XJiSFTBR{B4cXSqIFnDOVAhd2ZiMD6wPFMh|ryP NHvkbYoyQDV3OE[2PS=>
RAW264.7 NVnyRnI{TnWwY4Tpc44hSXO|YYm= MorqNkDPxE1? NFzjPHc{NjViaB?= MkD0SG1UVw>? MmTrRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5QhWGyjc33v[Il2dSCoYXzjbZBienWvIHnu[oVkfGWmIIfpeIghUUN3MDDv[kAxNjFzIN88US=> NHzme4kyQDZ2NEm2PS=>
NB4 MVO0PIg> Mn3ZSG1UVw>? NWmwN25NUUN3ME2wMlYh|ryP MkXyNVg4OjN|NEm=
HEK293 MmrzSpVv[3Srb36gRZN{[Xl? MknXNVAh|ryP MmfKNlQhcA>? MYLEUXNQ NXP2Z5pwSWO2aY\heIlwdiCxZjDtc5V{\SCZboSzZUB{cWewYXzpcoch\XiycnXzd4Vl NULFUmI2OTlyMkK2O|U>
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HepG2 M3K0[mtqdmG|ZTDBd5NigQ>? NUezVJQ1PSEQvF2= NXnyZ3hbPmh? Mnn1SG1UVw>? M2H1Wmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgbJlx\XKjY3X0fYxifGmxbh?= MX[yNFE1Ozh2MB?=
HepG2 NFnh[GxMcW6jc3WgRZN{[Xl? MUW1JO69VQ>? MYC2bC=> NHW3UFBFVVOR M3Phemlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NFzCfGczODF2M{i0NC=>
HepG2 NX\pO2NuU2mwYYPlJGF{e2G7 M3jScFUh|ryP M4HWclZp MmfUSG1UVw>? M3;NcWlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= MU[yNFE1Ozh2MB?=
COLO205 NFzXZnhMcW6jc3WgRZN{[Xl? MlXJNVAh|ryP NHKyOHEzPCCq NH3BVI1FVVOR MULJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizJIFk\XS7bHH0bY9vKHerdHigTWM2OCCxZjCyMlIh|ryP Mn24NlA1PTF|N{i=
SCC4 NHG0XZBMcW6jc3WgRZN{[Xl? NX;SO4xnOSEQvF2= MkHLNlRp MoLFTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= M2Kw[FIxPDV{MkK1
SCC4 M{PFdmtqdmG|ZTDBd5NigQ>? NX\XS5E3OSEQvF2= M2PyfFI1cA>? M1PVdmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIHHj[ZR6dGG2aX;u MUOyNFQ2OjJ{NR?=
SCC4 MXrGeY5kfGmxbjDBd5NigQ>? MVixJO69VQ>? MoDTOUBucW5? MmrsRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= NF33W4kzODR3MkKyOS=>
NB4 MkT3SpVv[3Srb36gRZN{[Xl? NWHhNnRxPSEQvF2= MUKyOEBp NXXzeWl1TE2VTx?= MVTD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn NX3wfVlMOjB2OUG0OFA>
NB4 MkTwT4lv[XOnIFHzd4F6 NFPYNVc2KM7:TR?= NFr5RnIzPCCq MmX3SG1UVw>? NIjkeo1KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gZYNmfHmuYYTlJJR2[nWuaX6gcIV3\Wx? NVPMSI5kOjB2OUG0OFA>
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CAL27 Mn\RR5l1d3SxeHnjJGF{e2G7 MVK3NkBp NUDmepRuS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MnXsNlExQDB4Mkm=
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Sf21 NUTlfWIyU2mwYYPlJGF{e2G7 M1r1XFMhcA>? NXjTW3IzUW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> MnTxNlExQDB4Mkm=
SKBR3 MU\DfZRwfG:6aXOgRZN{[Xl? MYO3NkBp M33aNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= MW[yNVA5ODZ{OR?=
SKOV3 MlG4R5l1d3SxeHnjJGF{e2G7 M3:5PVczKGh? MmXhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NIPBd40zOTB6ME[yPS=>
COR-L23 NVzKS4VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHUWI95OTBizszN M2HFUVczKGh? NY\3Rnk6TE2VTx?= M3vVZmdKPTB;MT6xJO69VQ>? MnHoNlExQDB4NEe=
DU145 MoP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\BdJBbOTBizszN MVO3NkBp M{LLO2ROW09? MWPHTVUxRTFwMEWg{txO MXqyNVA5ODZ2Nx?=
LoVo NFSzVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjsOmIyOCEQvF2= M1nTRVczKGh? M1\HRmROW09? NGK3clFIUTVyPUGuO{DPxE1? NX7POnJzOjFyOEC2OFc>
MCR5-SV2 NUPiU5ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL2NVAh|ryP M4LvXVczKGh? MVLEUXNQ M{DkN2dKPTB;Mj6xJO69VQ>? Ml3YNlExQDB4NEe=
HCT116 M{fXZmtqdmG|ZTDBd5NigQ>? NVi2bZN6OzBizszN NHvUbGw{OCCq NX;pTWk5TE2VTx?= NYPiN|hnUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> NEfHZW8zOTB6ME[0Oy=>
HCT116 MXLLbY5ie2ViQYPzZZk> NX;yZpJMOzBizszN NV7IW4J{OzBiaB?= NULRXIhjTE2VTx?= MVvJcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? M{exNVIyODhyNkS3
U937 NYPzVnpVU2mwYYPlJGF{e2G7 NXfNc5F{PSEQvF2= M3O0bFI1KGh? NUnxNnJ{TE2VTx?= M{HhemlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 NIP1b5YzOTJ7MkS5Ni=>
U937 NYDwelNOU2mwYYPlJGF{e2G7 M3iwclUh|ryP M1HvelI1KGh? NYTBem9ETE2VTx?= NX3ET|ZKUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 MkC1NlEzQTJ2OUK=
U937 NHrsbm1McW6jc3WgRZN{[Xl? M4W5VVUh|ryP MXOyOEBp MV3EUXNQ NIn2W2JKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= NIju[IkzOTJ7MkS5Ni=>
U937 M3vGSWtqdmG|ZTDBd5NigQ>? MUm1JO69VQ>? NHrJcHAyPSCvaX6= M4LrcmROW09? NXXSRmRnUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? MUWyNVI6OjR7Mh?=
A2780 M1zjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjOPVYhcA>? NH3mS49FVVOR M4fkTGlEPTB;MT62NkDPxE1? NUez[oc1OjF4M{S0N|A>
COLO205 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vydlk3KGh? Mnf3SG1UVw>? MmPiTWM2OD1{LkGyJO69VQ>? MYCyNVY{PDR|MB?=
Hep3B M{[xbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWS0PEBp NF\2UWFFVVOR MnLYS2k2OD1zLkKxJO69VQ>? NH;kT4UzOTdzMkG0Oi=>
GM11272 M2DqR2Z2dmO2aX;uJGF{e2G7 NEnQWpQyODBibl2= NHHQcWo4OiCq NUXF[4pjTE2VTx?= NHWybpFT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O M{jlW|IyQDRyN{G2
CFBE41o MXfLbY5ie2ViQYPzZZk> NFzEZZE2KM7:TR?= MX\EUXNQ M1fXWGRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? M3;YV|IyQTh2OUW4
CFBE41o M2f4NGZ2dmO2aX;uJGF{e2G7 M1XOXlEh|ryP MkP3NlQhcA>? MlTmSG1UVw>? NV7YN2FZWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z NGHhXHYzOTl6NEm1PC=>
DU145 MUTLbY5ie2ViQYPzZZk> NVPEUYVkOi53IN88US=> MVKyOEBp MlTZSG1UVw>? MlflTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> NYDZWoRUOjJ{NkCxOlY>
DU145 Mnq1T4lv[XOnIFHzd4F6 MYq1JO69VQ>? MmnKNlQhcA>? NUjKVY9uTE2VTx?= MX;Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= NFHmZoYzOjJ4MEG2Oi=>
DU145 M4DCUmtqdmG|ZTDBd5NigQ>? NITF[4E2KM7:TR?= NY\4fpFXOjRiaB?= NGfSbVNFVVOR MlHDTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? NXy4XZpsOjJ{NkCxOlY>
786-0 NU\KfHdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP1[npjPi5{IN88US=> MWq3NkBp MWTEUXNQ MV;HTVUxRTNwMjFOwG0> M3yzS|IzPDN3Nk[5
A498 NH;OPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPl[HlQPi5{IN88US=> MWi3NkBp NHz3cVJFVVOR NIj5ZmFIUTVyPUGuOkDPxE1? M{S1b|IzPDN3Nk[5
A549/ATCC M1v5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLXO3NGPi5{IN88US=> M2jT[|czKGh? M2rjNWROW09? MlPkS2k2OD1zLk[g{txO MnS4NlI1OzV4Nkm=
ACHN MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnv4Ok4zKM7:TR?= MVK3NkBp M1XITGROW09? NVz3c3d3T0l3ME2xMlMh|ryP MXOyNlQ{PTZ4OR?=
BT549 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVexZWgxPi5{IN88US=> MUC3NkBp Mlq4SG1UVw>? NIqzOpVIUTVyPUGuN{DPxE1? MV[yNlQ{PTZ4OR?=
EKVX M3\lUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\HT2o3NjJizszN NE\Fcog4OiCq Mn\zSG1UVw>? MV;HTVUxRTFwMzFOwG0> NFnSe|EzOjR|NU[2PS=>
HCT15 M1fOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYm2MlIh|ryP NFfpUYs4OiCq M3LoVWROW09? NGrvOVhIUTVyPUKuOUDPxE1? MlvlNlI1OzV4Nkm=
HOP92 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfhS3g3NjJizszN NFrJZpA4OiCq MUnEUXNQ NGTYToZIUTVyPUSg{txO MXqyNlQ{PTZ4OR?=
IGROV1 MoDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPHOk4zKM7:TR?= MWm3NkBp M1m1TGROW09? NW\xVJYzT0l3ME2xMlMh|ryP NVTTenRKOjJ2M{W2Olk>
LOXIMVI NV:3R|ZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvSd2g3NjJizszN MVS3NkBp MoT3SG1UVw>? NHnSO|RIUTVyPUGg{txO NULjVHdbOjJ2M{W2Olk>
M14 M3[2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVW2MlIh|ryP NF64XG04OiCq NV3NPWl4TE2VTx?= NX\VRVM2T0l3ME2xMlMh|ryP NIj2OnozOjR|NU[2PS=>
MALME-3M Mon0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzT2dtPi5{IN88US=> MoGxO|IhcA>? M2TjWmROW09? NXLDVIlOT0l3ME2wMlMzKM7:TR?= NV;mO4l4OjJ2M{W2Olk>
MCF10A NIDPR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVS2MlIh|ryP NFTzVWs1QCCq M{\rUmROW09? MXvHTVUxRTlwNjFOwG0> NWjifFQzOjJ2M{W2Olk>
MDA-MB-435 M4TzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrZOk4zKM7:TR?= MlK0O|IhcA>? NYCxenRGTE2VTx?= M3X5WWdKPTB;MD61JO69VQ>? M4HRNVIzPDN3Nk[5
MDA-MB-468 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnG[4k3NjJizszN MW[3NkBp MmfYSG1UVw>? NIDs[YRIUTVyPUCuOlMh|ryP M1PRdVIzPDN3Nk[5
MOLT4 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu2Ok4zKM7:TR?= NYrNSIs6PzJiaB?= MYjEUXNQ M3nM[mdKPTB;MD60JO69VQ>? M17GSFIzPDN3Nk[5
NCI-ADR-RES MoS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfPOk4zKM7:TR?= NG\jWGY4OiCq MoLRSG1UVw>? MYrHTVUxRTBwMU[g{txO NXfVR3B7OjJ2M{W2Olk>
NCI-H23 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO4PHQ3NjJizszN NEjMNmY4OiCq NHPjdmJFVVOR NXnUV4NST0l3ME2xJO69VQ>? MWKyNlQ{PTZ4OR?=
NCI-H322M NHXOR4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrYbnI3NjJizszN M2DDc|czKGh? MknNSG1UVw>? Mln3S2k2OD1yLke5JO69VQ>? MVGyNlQ{PTZ4OR?=
NCI-H460 M4fYeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;wOk4zKM7:TR?= MXe3NkBp NXjTV|JxTE2VTx?= M332WGdKPTB;MD63PUDPxE1? M{\mflIzPDN3Nk[5
NCI-H522 MoflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj3Ok4zKM7:TR?= MkS5O|IhcA>? MXHEUXNQ MX7HTVUxRTBwNTFOwG0> MWeyNlQ{PTZ4OR?=
OVCAR3 NEfiWGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHCOk4zKM7:TR?= Ml70O|IhcA>? M1mwSGROW09? MmTLS2k2OD1zLkOg{txO M3LJcVIzPDN3Nk[5
OVCAR4 NHH1R5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVK2MlIh|ryP NYHRNWVkPzJiaB?= M3\CUWROW09? NWnNVodLT0l3ME20JO69VQ>? MlS3NlI1OzV4Nkm=
OVCAR5 NXjxSXRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTzOk4zKM7:TR?= NIPGeXo4OiCq M2fFV2ROW09? NGDq[pFIUTVyPUCuO|kh|ryP M4DSN|IzPDN3Nk[5
OVCAR8 MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC2Ok4zKM7:TR?= M4PSRVczKGh? NGPoflBFVVOR MYfHTVUxRTBwNTFOwG0> NYnmb2kzOjJ2M{W2Olk>
RXF393 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDDOk4zKM7:TR?= MofwO|IhcA>? NGX2TnFFVVOR NEG4V|dIUTVyPUGuN{DPxE1? NXW4OItjOjJ2M{W2Olk>
SF268 NH;nWG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi2MlIh|ryP M{\2b|czKGh? NEe2XW1FVVOR MoXNS2k2OD1zLk[g{txO NF;iSXgzOjR|NU[2PS=>
SF295 M4XIdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zjcVYvOiEQvF2= NEXyNYM4OiCq M3TpcGROW09? MU\HTVUxRTFwNjFOwG0> M{TQVlIzPDN3Nk[5
SF539 NVz0d5hOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[2MlIh|ryP NHfMPHo4OiCq NViwNnloTE2VTx?= MoDzS2k2OD1{IN88US=> NEDNTZYzOjR|NU[2PS=>
SK-MEL-2 NYj3dpNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\BOk4zKM7:TR?= MmXPO|IhcA>? NV7wOIxpTE2VTx?= NF2ze21IUTVyPUGuN{DPxE1? M{jN[VIzPDN3Nk[5
SK-MEL-28 M2rJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnH[mY3NjJizszN NV;z[YFmPzJiaB?= MoHaSG1UVw>? MV7HTVUxRTFizszN MoK2NlI1OzV4Nkm=
SK-MEL-5 MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi5SoJWPi5{IN88US=> M{DGelczKGh? MkfqSG1UVw>? MkX1S2k2OD1yLk[zJO69VQ>? NYeyfHQ1OjJ2M{W2Olk>
SKOV3 NYGxNI86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHY[4k3NjJizszN NX7NZm41PzJiaB?= M3y0SGROW09? MXXHTVUxRTFizszN MU[yNlQ{PTZ4OR?=
SN12C Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL4Ok4zKM7:TR?= MnnKO|IhcA>? MVLEUXNQ M1\1V2dKPTB;MjFOwG0> NYnkemdLOjJ2M{W2Olk>
SNB19 NEjpc5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\XU3E3NjJizszN NGDKUZY4OiCq MojqSG1UVw>? MmnIS2k2OD1yLk[zJO69VQ>? M2\CUlIzPDN3Nk[5
SNB75 Ml[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlKwOk4zKM7:TR?= MXK3NkBp MYXEUXNQ NYrXb|hbT0l3ME2wMlc6KM7:TR?= NFzCR5MzOjR|NU[2PS=>
SR NX\lOJNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nObVYvOiEQvF2= M13aUlczKGh? NX3QeJM3TE2VTx?= MX;HTVUxRTBwNDFOwG0> M1zxdlIzPDN3Nk[5
T47D NX;UUotzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\rV|YvOiEQvF2= Mk\rO|IhcA>? MmjRSG1UVw>? MlPBS2k2OD1yLkWg{txO MXqyNlQ{PTZ4OR?=
TK10 MlPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTnbnM3NjJizszN M{eyV|czKGh? MWrEUXNQ NWDpXVlqT0l3ME2wMlY{KM7:TR?= MWKyNlQ{PTZ4OR?=
UACC257 Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVruNGR4Pi5{IN88US=> NULCN2lVPzJiaB?= MUTEUXNQ NGK3PGJIUTVyPUCuOUDPxE1? M2XSR|IzPDN3Nk[5
UACC62 NEnkRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PR[FYvOiEQvF2= MV[3NkBp M{PGVmROW09? MWDHTVUxRTBwNDFOwG0> NFTLdWMzOjR|NU[2PS=>
UO31 M1vaSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm5T|M3NjJizszN MliyO|IhcA>? NYrjRY9nTE2VTx?= NH3ZVoRIUTVyPUCuOUDPxE1? NGnPZ5YzOjR|NU[2PS=>
Hep3B Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[0PEBp MWHEUXNQ NVPzdHJnT0l3ME2wMlY6KM7:TR?= NV7Ld5ltOjJ2M{m4OlM>
BE(2)-C NIrxOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXG3NkBp NV62PJJKTE2VTx?= MVvJR|cxRTJizszN MVqyNlk{OjNzNh?=
Bel7402 M3\oV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUe3NkBp M{LqdGROW09? NF;YfZdIUTlyPUG3JO69VQ>? M4rL[|I{ODZzM{e2
Bel7404 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDGVVE4OiCq NVX1VmVSTE2VTx?= MYfHTVkxRTF6IN88US=> MX:yN|A3OTN5Nh?=
BGC823 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVu3NkBp M3y4OWROW09? MofkS2k6OD15LkWg{txO NFPCcFUzOzB4MUO3Oi=>
MGC803 M3vJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVi3NkBp M4\o[2ROW09? Mn;jS2k6OD1zMD64JO69VQ>? NVrFXZR{OjNyNkGzO|Y>
SGC7901 M33KTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjoO|IhcA>? MWDEUXNQ MW\HTVkxRTlwNDFOwG0> MofGNlMxPjF|N{[=
SKHEP1 MnGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXW3NkBp NU\mU5RMTE2VTx?= MknkS2k6OD1zNzFOwG0> NHPCT5czOzB4MUO3Oi=>
SMMC7721 NHyzNY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorBO|IhcA>? MYPEUXNQ NYfzZlhGT0l7ME2yNEDPxE1? NVfV[I1TOjNyNkGzO|Y>
NUGC3 M175dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWGxNEDPxE1? NHHKZZBIUT1{Lkm0JO69VQ>? M2j5UVI{OTZ|M{Oy
A2780 CisR NIOyXGNMcW6jc3WgRZN{[Xl? NUf4cVZYOThiaB?= M4PPNmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD60OEDPxE1? MnzLNlMzPTJ4MEO=
CAL27 sens NGL1N49McW6jc3WgRZN{[Xl? M3\OR|E5KGh? NF[xPHhKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Yh|ryP MUeyN|I2OjZyMx?=
CAL27 CisR NY[0fplNU2mwYYPlJGF{e2G7 M2PVRVE5KGh? MXXJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MUGyN|I2OjZyMx?=
KYSE-510 CisR MoPLT4lv[XOnIFHzd4F6 M4jjelE5KGh? NXGwTZJYUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= MYmyN|I2OjZyMx?=
KYSE-510 sens NXPENm5GU2mwYYPlJGF{e2G7 M1\NVVE5KGh? M4LBemlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? NEHOV|EzOzJ3Mk[wNy=>
MDA-MB-231 sens M1PhZ2tqdmG|ZTDBd5NigQ>? MV[xPEBp NVrSfWpnUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= MmWxNlMzPTJ4MEO=
MDA-MB-231 CisR NF7uNoZMcW6jc3WgRZN{[Xl? MWmxPEBp M3jFfWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M{TONVI{OjV{NkCz
ES2 M1nZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvrPFlrPDhiaB?= MVnEUXNQ NV7zS3lKUUN3ME2xNk44KM7:TR?= M3GxVFI{PDl|NES5
MDA-MB-231 MWXLbY5ie2ViQYPzZZk> MoX2NVAh|ryP NI\vfHE{OCCvaX6= NHXCcWVFVVOR NUi5bWxvUW6qaXLpeIlwdiCxZjDISGFEOmF? NVXzSXZxOjN2OUO0OFk>
MDA-MB-231 Mn\xT4lv[XOnIFHzd4F6 MkXFNUDPxE1? MWeyOEBp NV75eVJTTE2VTx?= NV\veG5sUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> Mme1NlM1QTN2NEm=
HS68 NH35dIJEgXSxdH;4bYMhSXO|YYm= NYXFOlBUOTBizszN MmO0O|IhcA>? M3uyemROW09? MV7JR|UxRTRwNjFOwG0> MkLNNlM2PzB3NEK=
MEF NH7WW2dEgXSxdH;4bYMhSXO|YYm= MlX2NVAh|ryP NWDDOFZqPzJiaB?= MmXESG1UVw>? NUPOboRpUUN3ME20MlQh|ryP MlXhNlM2PzB3NEK=
BGC823 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorNSG1UVw>? M2HaWGdKPTB;Mz6wPUDPxE1? NXu0[ZEyOjN4MEG3NFY>
High5 MkfYT4lv[XOnIFHzd4F6 MWWyOEBp NF\wOllKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MVOyN|YxOjV{Mx?=
High5 M1LCWWtqdmG|ZTDBd5NigQ>? NX3CeGM1OjRiaB?= M4\RUWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP NUjRfotSOjN4MEK1NlM>
High5 NXHIcW1OU2mwYYPlJGF{e2G7 MWKyOEBp M{jNR2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP M3;KbVI{PjB{NUKz
A549 MoHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrpN25VTE2VTx?= NF7EWlJKSzVyPUGuNFc6KM7:TR?= MniwNlM3PDR{MUC=
HCT116 M2\6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTlSG1UVw>? M{\GVGlEPTB;MD63OVch|ryP MXWyN|Y1PDJzMB?=
K562 NIPSS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\6SG1UVw>? M1XLN2lEPTB;MD62OFUh|ryP NUm4ZohCOjN4NESyNVA>
GBC-SD MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXj[nY2KM7:TR?= MoLLO|IhcA>? M3XmWGROW09? MV\JR|UxRTF2Lkig{txO Mm\3NlM4ODd{NkC=
HGC27 MmP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkX3OUDPxE1? MYe3NkBp MmPzSG1UVw>? NYLjbpU4UUN3ME21MlQh|ryP MV:yN|cxPzJ4MB?=
HL60 MoK2T4lv[XOnIFHzd4F6 NGTYXYg2KM7:TR?= NWPBTHhFOjRiaB?= MlLmSG1UVw>? NUHp[ZJVUW6qaXLpeIlwdiCxZjDISGFE NXXxTHVJOjN5MEeyOlA>
Vero NH7IUW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPrO|IhcA>? NUXzSJo{TE2VTx?= MlrMTWM2OD1yLkmg{txO MUCyN|c5PjR3Mh?=
NCI60 NHKxZ2xEgXSxdH;4bYMhSXO|YYm= NFL5bos1QCCq MV3EUXNQ M2PsNGdKRTBwNUOg{txO MoHjNlQxOTV|Mke=
SW620 NYnWVXQxS3m2b4TvfIlkKEG|c3H5 NHTXSZI1QCCq MlG4SG1UVw>? MorYS2k:OC53NDFOwG0> M{nZW|I1ODF3M{K3
U251 MWnDfZRwfG:6aXOgRZN{[Xl? M{TXW|Q5KGh? MkTwSG1UVw>? MU\HTV0yNjV|IN88US=> M{ntOVI1ODF3M{K3
KM12 NHPaeY9EgXSxdH;4bYMhSXO|YYm= MkfJOFghcA>? NH;vVYxFVVOR Moj3S2k:OS56ODFOwG0> NEOweoMzPDBzNUOyOy=>
Hs578T M3jROmN6fG:2b4jpZ{BCe3OjeR?= M{HJZ|Q5KGh? Mor2SG1UVw>? M4nUOWdKRTRwOEOg{txO MXOyOFAyPTN{Nx?=
MDA-MB-231 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[0PEBp MonGTWM2OD1yLkG2JO69VQ>? MljpNlQxQTVyMU[=
MCF7 NUfVbnV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;Zb3p[PDhiaB?= MYTHTV0xNjR3IN88US=> NIG4emUzPDFzOUW1OS=>
MDA-MB-435 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYO0PEBp NHu5UFNIUT1yLki4JO69VQ>? NWexZow{OjRzMUm1OVU>
AsPC1 NUS4PFhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqzNEDPxE1? MlLrOFghcA>? M2LVcWROW09? NUnIfWZuUUN3ME2zMlY3KM7:TR?= NGToVo0zPDF6NUO3PC=>
Jurkat E6.1 MWXLbY5ie2ViQYPzZZk> NHPJc28zKGh? MWPEUXNQ Mm[5TY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? MYWyOFI3OTh4Mh?=
KG1 M2PONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInuVWU1QCCq NXP0ZYprUUN3ME2xMlE2KM7:TR?= MoTDNlQ2OjVyMEO=
HEL M2fsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTIOFghcA>? MVfEUXNQ M1XtXmlEPTB;MD60PUDPxE1? MmXoNlQ3QTRyNUW=
HSC3 M2rDbmN6fG:2b4jpZ{BCe3OjeR?= NEHiZWcyOiCq NXvxUpFnTE2VTx?= MoDKTWM2OD1yLkexJO69VQ>? M{[1cVI1PzZ4NU[w
HT-29 M1v1N2N6fG:2b4jpZ{BCe3OjeR?= MnTlNVIhcA>? M{ixSWROW09? NHHjOnhKSzVyPUCuO|Ih|ryP NHjYfYkzPDd4NkW2NC=>
KB MVzDfZRwfG:6aXOgRZN{[Xl? M3n6eVEzKGh? NV31R2xpTE2VTx?= NH\M[GpKSzVyPUCuO|Uh|ryP M4XWU|I1PzZ4NU[w
H460 MXjDfZRwfG:6aXOgRZN{[Xl? Mo\zNVIhcA>? MXrEUXNQ NHLnZmlKSzVyPUCuPFIh|ryP NX3TSIJQOjR5Nk[1OlA>
MONE1 MVzDfZRwfG:6aXOgRZN{[Xl? MoL0NVIhcA>? NFXDdY9FVVOR NWnINWg6UUN3ME2xMlE5KM7:TR?= M2XjdFI1PzZ4NU[w
MKN45 MmHiR5l1d3SxeHnjJGF{e2G7 M3TDXFEzKGh? NF;5XJNFVVOR MmO4TWM2OD1zLkK1JO69VQ>? MmrlNlQ4PjZ3NkC=
TSGH NXrrc49vS3m2b4TvfIlkKEG|c3H5 M2fNUVEzKGh? MX;EUXNQ NXzpRXQ2UUN3ME2yMlA6KM7:TR?= M2X0S|I1PzZ4NU[w
HL60 NWn4W|I{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn5TpI4OiCq NX;oPY02TE2VTx?= MVTHTVUxRTBwOUOg{txO NVfFSZlVOjR7MEC1NFA>
HEK293 M2CzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUe3NkBp M{Xh[GROW09? NEL3c3NIUTVyPUGzJO69VQ>? NF7uSngzPDlyMEWwNC=>
Jurkat M1PnSmN6fG:2b4jpZ{BCe3OjeR?= MWGxNFAh|ryP M2[xeVczKGh? MX7HTVUxRTBwOTFOwG0> M{SwWFI1QTByN{Sz
GM15850 MVrLbY5ie2ViQYPzZZk> M2iyV|IvPSEQvF2= NIDIXIo6PiCq M2jlOGROW09? M4rnboRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MXuxOlkzOTN4Nx?=
GM15850 MWPLbY5ie2ViQYPzZZk> NFjRbZAzNjVizszN MWe5OkBp MXvEUXNQ NFr3VZBld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhPSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NYLVUXJNOTZ7MkGzOlc>
GM15850 NXXVSJNzU2mwYYPlJGF{e2G7 M1\KZ|IvPSEQvF2= MkHBPVYhcA>? MXXEUXNQ NHrRTolld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTJiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NX\3[|IxOTZ7MkGzOlc>
GM15850 NVPFU3U1U2mwYYPlJGF{e2G7 NHLvfVMzNjVizszN MW[5OkBp NGHzbHNFVVOR NIrDe21ld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NVfVZ4ltOTZ7MkGzOlc>
GM15850 NF;6VpVMcW6jc3WgRZN{[Xl? MYSyMlUh|ryP Ml\1PVYhcA>? NHjYW4JFVVOR Mnj2[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M4\3c|E3QTJzM{[3
GM15850 MXTLbY5ie2ViQYPzZZk> NYjtSIk1Oi53IN88US=> NFHxVXo6PiCq NV;VWXFNTE2VTx?= MVrkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NXrjc|d4OTZ7MkGzOlc>
GM15850 NYHPOJB[TnWwY4Tpc44hSXO|YYm= MVq1JO69VQ>? NVfHUI1EOTJiaB?= NVTSRWdZTE2VTx?= MWroZZMhdm9iZX\m[YN1KG:wIF\YUkBuWk6DIHX4dJJme3Orb36= M2fJ[VE3QTJzM{[3
U937 M2nWNWtqdmG|ZTDBd5NigQ>? NWCzZlFJPSEQvF2= M2HMS|I1KGh? NFP2Zo9FVVOR MkTJbIF{KG6xIHXm[oVkfCCxbjDhcJBp[SC2dXL1cIlvKGGlZYT5cIF1cW:w M4f1ZlE4PDR5N{Ww
U937 MXPLbY5ie2ViQYPzZZk> MkLxNUDPxE1? M3PPN|I1KGh? NUjxZox[TE2VTx?= NYi5co1TcGG|IH7vJIVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u NYHrOGVbOTd2NEe3OVA>
PANC1 NGC3ZYxHfW6ldHnvckBCe3OjeR?= NXnzcnBMOSEQvF2= M4HDPVI1KGh? NXXqZ2dZ\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NIPMUW8yPzV6OEe0OC=>
PANC1 NF\Te5lHfW6ldHnvckBCe3OjeR?= M4TSc|Eh|ryP M1PReVQ5KCCq NV\PUIM{\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NECxT2YyPzV6OEe0OC=>
Caco-2 NX7aZXNxTnWwY4Tpc44hSXO|YYm= MWm1JO69VQ>? MU[yOEBp NX35UHpbTE2VTx?= MVLkc4V{KG6xdDDpcoR2[2ViUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MnHpNlAyPDN6NEC=
SCC4 Mk\oSpVv[3Srb36gRZN{[Xl? MX6xJO69VQ>? MXyxNEBucW5? NIXGNWRFVVOR MWToZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? Ml;CNlA1PTJ{MkW=
A549 M4X5UmZ2dmO2aX;uJGF{e2G7 NHrKR|M2KM7:TR?= NGqwR4w{KGh? MofMSG1UVw>? NYHSdox2\G:nczDuc5QhcW6mdXPlJIF2fG:yaHHnfUBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|NKUQ>? NILyVXIzODh3NUKwPC=>
HCT116 MYrLbY5ie2ViQYPzZZk> M{PTUVAvOyEQvF2= M1HUPFMxKGh? NY\2TFFFTE2VTx?= NFHrbI9ld2W|IH7veEBqdmirYnn0JGhFSUNzIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCqaYP0c45mKEh|S{mgZYNmfHmuYYTpc44> NWP0bnVQOjFyOEC2OFc>
HepG2 MmPOSpVv[3Srb36gRZN{[Xl? NEThOnAyOCEQvF2= M1PvflI1KGh? NXKzeo9CTE2VTx?= MkHW[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BpgXCncnHj[ZR6dGG2aX;uJI9nKHB3Mx?= M{f0V|IyPTR6NUiy
GM11272 MWTGeY5kfGmxbjDBd5NigQ>? MVSwMlEh|ryP MkeyO|IhcA>? NIi2epdFVVOR MmSw[I9meyCwb4SgdoVi[3SrdnH0[UBO\UOyMjDteZRidnRiZYjwdoV{e2mxbh?= M4fYdFIyQDRyN{G2
MDA-MB-231 NV\pSpRVU2mwYYPlJGF{e2G7 M{fJNVExKM7:TR?= MYO1JI1qdg>? NXPF[m5CTE2VTx?= M4nnfoRw\XNibn;0JIlvcGmkaYSgTGRCSzKj M2DhV|I{PDl|NES5
MDA-MB-231 MlrpT4lv[XOnIFHzd4F6 NWTLTHdZOSEQvF2= MmjWNlQhcA>? NX21TZZOTE2VTx?= Mlfq[I9meyCwb4SgbY5pcWKrdDDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NHTNN2QzOzR7M{S0PS=>
K562 NHTpcGFMcW6jc3WgRZN{[Xl? MWXkc4V{KG6xdDDpcohq[mm2IFjERWM> MYOyN|U6OTFzMR?=
Jurkat MkjHR5l1d3SxeHnjJGF{e2G7 MkLRNlAh|ryP NUDoWVFsPzJiaB?= NFjHNYpFVVOR MkfPco8h[3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;u NYTnSHBxOjR|MESzOFg>
HCT116 M{HzZ2Fxd3C2b4Ppd{BCe3OjeR?= MnzuN{DPxE1? Mk\uNlQhcA>? M33vR2ROW09? Moi0[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCyNUOgdJJwfGWrbjDs[ZZmdA>? NFPDPGEzPDd4NkW2NC=>
KASUMI-1 NGPXUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TV[GlEPTB;OUmuNVchdk1? M1XDOXNCVkeHUh?=
KARPAS-45 M{njNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPGUJFKSzVyPUG3N{45QSCwTR?= NH7ieFVUSU6JRWK=
BHT-101 NFnPW5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXkTWM2OD1{NESuNVghdk1? MYXTRW5ITVJ?
H9 M1LIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfpOnVKSzVyPUK1OU4xPCCwTR?= NV[1TXNJW0GQR1XS
PA-1 M2X5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n5dmlEPTB;Mki2MlI3KG6P MoTwV2FPT0WU
NEC8 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPOXZNKSzVyPUK4PU4{QCCwTR?= NIjad5pUSU6JRWK=
MHH-PREB-1 NGPSXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HLUGlEPTB;Mkm0MlU{KG6P NY\nPIZHW0GQR1XS
NB7 MmXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHMcZZxUUN3ME2zOFUvPzRibl2= Mn\ZV2FPT0WU
A3-KAW MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\DbmRKUUN3ME20NFAvPTlibl2= NWLQVIUyW0GQR1XS
NB69 M4HSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HvVWlEPTB;NEGxMlcyKG6P Mkn2V2FPT0WU
EoL-1-cell NH;jepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR3NEK1JI5O NU[1ZVlyW0GQR1XS
CHP-212 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTR3Nz61N{BvVQ>? MlPiV2FPT0WU
C2BBe1 NEP1cGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXZbIhKSzVyPUS3Nk4yQSCwTR?= M3PnfXNCVkeHUh?=
697 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCzTWM2OD12N{OuOFEhdk1? NWjScFUzW0GQR1XS
BCPAP MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTVyMT60NkBvVQ>? M2izUHNCVkeHUh?=
L-363 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnhPVdwUUN3ME21NFMvOSCwTR?= MUnTRW5ITVJ?
ES8 NH3CdFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi5b3NKSzVyPUWyN{42OyCwTR?= NY\SPJBQW0GQR1XS
BE-13 M{HVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnibXhXUUN3ME21NlYvQTZibl2= NWrzUHBwW0GQR1XS
CTB-1 M3XzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmraTWM2OD13M{euPVIhdk1? M{e4bXNCVkeHUh?=
HD-MY-Z MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\yW3pDUUN3ME21N|gvOTNibl2= NVHzb|BsW0GQR1XS
NKM-1 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTV2ND6yO{BvVQ>? MlO0V2FPT0WU
NCI-H720 M1roR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ywWGlEPTB;NU[wMlE5KG6P MXnTRW5ITVJ?
KY821 M3rJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHThXpBKSzVyPUW2N{4zPSCwTR?= MnHmV2FPT0WU
OVCAR-5 M4HTNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP6TWM2OD13N{[uNVEhdk1? Ml70V2FPT0WU
CTV-1 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILVOmRKSzVyPUW4NU42PiCwTR?= MonUV2FPT0WU
P12-ICHIKAWA MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDpXHZKSzVyPUW5Ok42OSCwTR?= NH7EUVNUSU6JRWK=
DB NETxcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTV7OD61O{BvVQ>? NFX3fIdUSU6JRWK=
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HN Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrLTWM2OD1zLki4O|I2KM7:TR?= NVvqem86W0GQR1XS
HT MmXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjMcIJCUUN3ME2xMlg5QTR5IN88US=> MoLaV2FPT0WU
LoVo MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrwbYJWUUN3ME2xMlg6QDFizszN NYHDTItzW0GQR1XS
CGTH-W-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfwdG5PUUN3ME2xMlg6QTR4IN88US=> MojLV2FPT0WU
NB6 MlzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrLXGFvUUN3ME2xMlkyOjl6IN88US=> M4XiVnNCVkeHUh?=
EW-22 NUOw[nBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwOUK4PFch|ryP Ml:4V2FPT0WU
ES6 MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTFwOUO2N|Eh|ryP MkTpV2FPT0WU
SCC-15 M4LGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTNTWM2OD1zLkmzPFE6KM7:TR?= NFi3V4xUSU6JRWK=
HL-60 NHjNRYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHudIZKSzVyPUGuPVM6ODJizszN NGP6NWJUSU6JRWK=
human HOP-92 MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ueGlEPTB;MT65OFA3PSEQvF2= M1nFd3NCVkeHUh?=
SW626 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGO5UVBKSzVyPUGuPVQ5QTlizszN MUDTRW5ITVJ?
HEC-1 NWPtZY12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPmU4xKSzVyPUGuPVU{PiEQvF2= NFvpeoRUSU6JRWK=
LB2241-RCC NXyxbYpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFwOUiyN|Eh|ryP NXrQZ3JFW0GQR1XS
Ramos-2G6-4C10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\tPYtKSzVyPUGuPVk1QTNizszN M4n6c3NCVkeHUh?=
A101D Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP2TWM2OD1{LkKwN|A{KM7:TR?= Mnr3V2FPT0WU
NCI-H446 M1LJTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfRfHdKSzVyPUKuNFQ2QTlizszN M3rPXXNCVkeHUh?=
SBC-5 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJwME[xOFch|ryP NXW2bmhCW0GQR1XS
HOS NFrpPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[3fGlEPTB;Mj6wO|Y2OyEQvF2= NYHsR|dxW0GQR1XS
K5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjDfINKSzVyPUKuNFc5OTFizszN NY\sWHlHW0GQR1XS
HLE MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnUTWM2OD1{LkC4OVI6KM7:TR?= MofnV2FPT0WU
HSC-2 NHH2bmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ewc2lEPTB;Mj6xNlg6QCEQvF2= MWfTRW5ITVJ?
LCLC-97TM1 NUDoeVR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPoTWM2OD1{LkG0OVg{KM7:TR?= NYrBPYk3W0GQR1XS
DMS-273 MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C0XGlEPTB;Mj6xOFg{PyEQvF2= NX3tO5FyW0GQR1XS
TE-8 NGnZeZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H2O2lEPTB;Mj6xOVc3PSEQvF2= M4\BWnNCVkeHUh?=
DSH1 MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXtTWM2OD1{LkG2N|k5KM7:TR?= NE\1TFZUSU6JRWK=
CAL-51 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwMU[2PVkh|ryP NETSO3VUSU6JRWK=
IST-SL1 MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfTWm9JUUN3ME2yMlE3QDR2IN88US=> MnzCV2FPT0WU
GCT NXPkVoxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\HbmdSUUN3ME2yMlE4PzdizszN NVztZmpSW0GQR1XS
SW948 NHnWR2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXFRo9vUUN3ME2yMlE5PDV4IN88US=> M17yU3NCVkeHUh?=
NOMO-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP3d|BOUUN3ME2yMlE6OzF5IN88US=> M2rOZ3NCVkeHUh?=
C8166 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwMkGzN|Qh|ryP M3LwXXNCVkeHUh?=
OC-314 M3fteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPxXohKSzVyPUKuNlMzPTlizszN M1PER3NCVkeHUh?=
CAL-39 NFTubZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn1WoNKSzVyPUKuNlM3OjZizszN MWLTRW5ITVJ?
MDA-MB-453 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwMkSyO|Uh|ryP NGD5OWNUSU6JRWK=
A673 NF\YdZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTiTWM2OD1{LkK1PFYzKM7:TR?= Mn3SV2FPT0WU
HTC-C3 NHHhe3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13r[mlEPTB;Mj6yOlg2KM7:TR?= NWLHNoNGW0GQR1XS
NCI-H1666 NUXFcYFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\pZm9iUUN3ME2yMlI5OTFzIN88US=> MmnmV2FPT0WU
PSN1 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofMTWM2OD1{LkK4PVE{KM7:TR?= NHToTlNUSU6JRWK=
GI-1 M17TWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTZRolYUUN3ME2yMlMxPTR|IN88US=> MoCyV2FPT0WU
HuH-7 M1roNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX1cnNMUUN3ME2yMlMxPjN5IN88US=> MmrWV2FPT0WU
JAR M{O3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3wTWM2OD1{LkOxPVg4KM7:TR?= NGnxdFVUSU6JRWK=
5637 NHPNc5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Lx[WlEPTB;Mj6zNlEzQSEQvF2= M2DReXNCVkeHUh?=
GB-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjXNXBKSzVyPUKuN|I{OzVizszN MWTTRW5ITVJ?
KP-N-YS NFL5[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17EZWlEPTB;Mj6zNlYyPSEQvF2= MYLTRW5ITVJ?
OAW-42 NF7LU|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7BTWM2OD1{LkOzOFE3KM7:TR?= MYTTRW5ITVJ?
8-MG-BA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwM{O5NFYh|ryP MlTYV2FPT0WU
RH-18 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHERXlOUUN3ME2yMlM2ODJ{IN88US=> NY\VR3lNW0GQR1XS
NCI-H1155 NEfrbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rEc2lEPTB;Mj6zOlczPSEQvF2= NEj0boJUSU6JRWK=
NB17 NWnPOlFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJwM{iyOFMh|ryP MUTTRW5ITVJ?
NCI-H1437 NFrhZotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Lh[WlEPTB;Mj60NVg4OyEQvF2= NXPiRm5KW0GQR1XS
SN12C NX21[WxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJwNEOyNVQh|ryP MVfTRW5ITVJ?
HSC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnwSJZXUUN3ME2yMlQ1PTB7IN88US=> MWHTRW5ITVJ?
GAMG NEDuSW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPZPHFKSzVyPUKuOFQ2PjFizszN NVTmSWVzW0GQR1XS
HT-1080 NXvPfpJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrnTXcxUUN3ME2yMlQ1QDZ2IN88US=> MV3TRW5ITVJ?
A549 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fDTmlEPTB;Mj60OFg6OyEQvF2= Mn3vV2FPT0WU
KNS-62 NE\hS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO0WoF4UUN3ME2yMlQ2ODZzIN88US=> NGXwfHpUSU6JRWK=
YKG-1 M{LUOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWntfGZHUUN3ME2yMlQ2PDN5IN88US=> M3i3bnNCVkeHUh?=
LU-134-A MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwNEewNFgh|ryP MkCyV2FPT0WU
FADU NYfjRY5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjW[WN4UUN3ME2yMlQ4OTZ{IN88US=> MY\TRW5ITVJ?
TGBC11TKB NHfvTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LSW2lEPTB;Mj60O|E4PyEQvF2= MlrDV2FPT0WU
HT-3 M1TZV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPrS2VKSzVyPUKuOFk2OzVizszN NVfWNIRkW0GQR1XS
NCI-H2170 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTiS2ZsUUN3ME2yMlUxPTR7IN88US=> NGLufGFUSU6JRWK=
Mo-T M{TsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV31d2JZUUN3ME2yMlUxQTJ5IN88US=> MoLPV2FPT0WU
CCRF-CEM NXXj[3M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn6SFJXUUN3ME2yMlU{ODR|IN88US=> NGTUUoVUSU6JRWK=
KU-19-19 M3HIeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNUO1NVMh|ryP NHjSWYJUSU6JRWK=
NCI-H1048 NF;ueIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L0T2lEPTB;Mj61OVAzPSEQvF2= NWriSYZjW0GQR1XS
KOSC-2 MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7YS441UUN3ME2yMlU3ODd4IN88US=> MYHTRW5ITVJ?
A431 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwNU[zN|Uh|ryP NX23XIVDW0GQR1XS
COR-L23 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXOTWM2OD1{LkW4OVY3KM7:TR?= M2fYeXNCVkeHUh?=
MKN28 NH3nTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3ZNZpKSzVyPUKuOVkxOzdizszN MnXSV2FPT0WU
22RV1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJwNUmyO|Qh|ryP MnPBV2FPT0WU
ABC-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJwNkC0OkDPxE1? MWLTRW5ITVJ?
NCI-H2126 M3jVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfOeot{UUN3ME2yMlYxQTh2IN88US=> M1H5OnNCVkeHUh?=
DoTc2-4510 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVroVmlCUUN3ME2yMlYzOTh3IN88US=> M33BWHNCVkeHUh?=
SCC-4 M2\nVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DReGlEPTB;Mj62N|AyOiEQvF2= NHXJe|VUSU6JRWK=
NCI-H661 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnMTWM2OD1{Lk[0NFg2KM7:TR?= MYfTRW5ITVJ?
RPMI-2650 M1z0[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfJc|lKSzVyPUKuOlQyPDNizszN M{fWTHNCVkeHUh?=
NCI-H510A Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjPTWM2OD1{Lk[0OFI3KM7:TR?= NUHlT3c2W0GQR1XS
BPH-1 MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Oy[mlEPTB;Mj62OVg2KM7:TR?= MYfTRW5ITVJ?
M14 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTaTWM2OD1{Lk[2PVk{KM7:TR?= M{nsUXNCVkeHUh?=
G-402 NW\JNlBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M164[2lEPTB;Mj63NFQ2OSEQvF2= MnfJV2FPT0WU
AsPC-1 MnHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPqZWhKSzVyPUKuO|EyPyEQvF2= M3G4[XNCVkeHUh?=
NB12 M3:0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUixOpBzUUN3ME2yMlcyPzFizszN NUDQN2FTW0GQR1XS
SK-HEP-1 NFzhb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X0eGlEPTB;Mj63OFM6OSEQvF2= M4fMTnNCVkeHUh?=
U-266 NXvWcIVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELh[3dKSzVyPUKuO|cyOjFizszN M1HGUnNCVkeHUh?=
AM-38 NVz0Z2s6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ZTmlEPTB;Mj63O|M2PSEQvF2= NFLXd4RUSU6JRWK=
PC-14 NHXnNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O0XmlEPTB;Mj64NFUyKM7:TR?= MVrTRW5ITVJ?
EGI-1 NXnHb5FDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwOEG3OFMh|ryP Mkn4V2FPT0WU
LS-411N M4fPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rofWlEPTB;Mj64NlM{KM7:TR?= NXP5bYhOW0GQR1XS
BFTC-905 M1riXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[z[o1KSzVyPUKuPFU2OjNizszN NETYdmJUSU6JRWK=
CaR-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH6ydnBKSzVyPUKuPFYh|ryP NULOTmxvW0GQR1XS
NCI-H292 NGfxWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DV[2lEPTB;Mj64OlU6PiEQvF2= MYTTRW5ITVJ?
8305C MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jBcmlEPTB;Mj64OlY1PSEQvF2= NUnmfllzW0GQR1XS
SNU-449 NELNWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[ySpJKSzVyPUKuPFkyQDJizszN NY\vcY1VW0GQR1XS
LCLC-103H NETYOWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3HPZRKSzVyPUKuPVA1OzhizszN MXXTRW5ITVJ?
SW1573 NGHnendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj6V4RKSzVyPUKuPVYxQDJizszN M3\rSnNCVkeHUh?=
MLMA Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDyOZNKSzVyPUKuPVY4OTdizszN NF\yZldUSU6JRWK=
NCI-H1355 M1z6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XRW2lEPTB;Mz6wNFc6PiEQvF2= MknqV2FPT0WU
RMG-I NFvBemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInocZZKSzVyPUOuNFI2QTJizszN MVHTRW5ITVJ?
BB65-RCC M2XV[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHOeHhWUUN3ME2zMlA{OzF2IN88US=> M{f6dXNCVkeHUh?=
PC-3 MlHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;EXZVTUUN3ME2zMlA{QDd2IN88US=> NWCzOVg2W0GQR1XS
SF268 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvab2JKSzVyPUOuNFQ2OjNizszN NYf2UXBjW0GQR1XS
NCI-H810 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTNwMES4NlMh|ryP M3fTdXNCVkeHUh?=
MEG-01 NEHmOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfJd|llUUN3ME2zMlA3OTZ2IN88US=> NGfzNG5USU6JRWK=
SW13 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vFOmlEPTB;Mz6wO|g1PyEQvF2= MWLTRW5ITVJ?
RH-1 M3T4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XBSGlEPTB;Mz6xNFI4QCEQvF2= MU\TRW5ITVJ?
GT3TKB NWDtZohjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXyTWM2OD1|LkGxNlg{KM7:TR?= MkLzV2FPT0WU
TK10 M1;OdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;NUGlEPTB;Mz6xN|czPCEQvF2= M{LmcHNCVkeHUh?=
T-24 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTNwMUWwO{DPxE1? NHHxSmtUSU6JRWK=
A498 NGDJZYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HjWmlEPTB;Mz6yNFg4OSEQvF2= MWHTRW5ITVJ?
GR-ST NX\hZYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;qSnJKSzVyPUOuNlIyOzlizszN MXfTRW5ITVJ?
LB2518-MEL MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjM[2FwUUN3ME2zMlIzOzl6IN88US=> MWLTRW5ITVJ?
T47D NVTjUFFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPlTWM2OD1|LkKzOlI4KM7:TR?= MVPTRW5ITVJ?
NCI-H1651 MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzmN41KSzVyPUOuNlQ3PDRizszN NHvUOWFUSU6JRWK=
EC-GI-10 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjYNFhoUUN3ME2zMlI3OTV|IN88US=> NUfTZY1NW0GQR1XS
HT-29 NF3ybZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTNwMk[2NVQh|ryP MUXTRW5ITVJ?
GI-ME-N MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4n5WmlEPTB;Mz6yPVUyOSEQvF2= NF3CS5dUSU6JRWK=
SW756 M{PkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTNwMkm2Nlkh|ryP MnT6V2FPT0WU
RKO MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNwM{C3OVch|ryP MljKV2FPT0WU
NCI-H1563 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\rVVJKSzVyPUOuN|MxOThizszN NEPPZ4JUSU6JRWK=
DJM-1 M4XoNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTNwM{e2O|Qh|ryP MkjnV2FPT0WU
L-428 NV:2XHQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvxTWM2OD1|LkSwNFQ2KM7:TR?= MX3TRW5ITVJ?
NCI-H2122 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\X[IFKSzVyPUOuOFE{OTJizszN NYnCNoxkW0GQR1XS
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COLO-678 NVGwOYk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33MRWlEPTB;MkeuOFkyQSEQvF2= NVf1UHdjW0GQR1XS
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NCI-H1650 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfrTWM2OD1|MD6xPVI1KM7:TR?= NW[ySY9KW0GQR1XS
HCC1954 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL1TINKSzVyPUOxMlM3PjZizszN NFvhT4JUSU6JRWK=
GAK MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPwTWM2OD1|Mj6yOlE3KM7:TR?= MUfTRW5ITVJ?
YAPC NF3UNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTN|Lke2OFgh|ryP M3XsNnNCVkeHUh?=
NCI-H2228 NWHlboJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTN2LkO2NFUh|ryP MYHTRW5ITVJ?
VMRC-RCZ M3nHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\IcHZ7UUN3ME2zOk4{ODJ{IN88US=> NFLYT|BUSU6JRWK=
NMC-G1 M{HtNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTN5LkC1Nlkh|ryP NFHqfo1USU6JRWK=
D-336MG NUjacHVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O3dWlEPTB;NEGuPFQ1OiEQvF2= MY\TRW5ITVJ?
UACC-62 NWD5[HZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTR{LkW1NFUh|ryP MnXRV2FPT0WU
C-33-A NVTCXoR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPkTWM2OD12NT6zNlU3KM7:TR?= MWfTRW5ITVJ?
HCC1937 MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLrdXBKSzVyPUS3MlE6PThizszN M3;SXHNCVkeHUh?=
HDLM-2 NYPtU3dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrwXFNKSzVyPUS3MlIzQDdizszN NVnOZ3JjW0GQR1XS
NCI-H727 M1r6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjXcYJKSzVyPUS3MlI1PTFizszN NE\hW3dUSU6JRWK=
NY NEn2XFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTR7LkO5NFgh|ryP NGXROmhUSU6JRWK=
NCI-H2291 NF;xPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTSTWM2OD12OT64N|AyKM7:TR?= NEnKWIFUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Suspended Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID