Vorinostat (SAHA)

For research use only.

Catalog No.S1047 Synonyms: MK0683

305 publications

Vorinostat (SAHA) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

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Selleck's Vorinostat (SAHA) has been cited by 305 publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M{j0XmtqdmG|ZTDBd5NigQ>? M1rVXFEhcA>? MVjEUXNQ NUXT[lFO[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN MmrCNVE6PjB2OEm=
Friend leukemic cell MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XWd|UxKM7:TR?= NGq4cJI4OiCq NXHm[mlSTE2VTx?= MUfJR|UxRTBwOUmg{txO NWfLPGJwOTJzMEm5NVM>
K562 MWfLbY5ie2ViQYPzZZk> M4TDdlYhcA>? Mkm2SG1UVw>? NHjCdGVKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> MWWxNlQyQTN6MB?=
HT1080 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL3O|IhcA>? NGfoUo5FVVOR NUPXXYF6UUN3ME2yMlQh|ryP NHHo[JgyOjJ5MEG3OS=>
H1299 M2K5dWtqdmG|ZTDBd5NigQ>? MVGyNEBucW5? Mn\vSG1UVw>? MoLyTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= MW[xOFUzOTR{Mh?=
H1299 MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fySVczKGh? M2DGWmROW09? MYDJR|UxRTdwMkSg{txO NVT6SXBuOTR3MkG0NlI>
HeLa NE[wfZBMcW6jc3WgRZN{[Xl? MWizNEBucW5? NFHFb3hKdmirYnn0c5J6KGOxbnPlcpRz[XSrb36gZYdicW6|dDDobZN1d26nIHTlZYNmfHmuYYPlJJdqfGhiSVO1NEBw\iByLkK4JO69VQ>? NUnMR412OTV4MEO5OFk>
LOX-IMVI NGDwbYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWG0PEBp NF7NXJhKSzVyPUGuN{DPxE1? Ml;mNVU4OTV2N{C=
NCI-H226 NUHaelVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUG0PEBp NUjwPFNnUUN3ME2yMlYh|ryP NVHTcoZ7OTV5MUW0O|A>
RXF-631L NXe5dnhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUe0PEBp NXr2OG1nUUN3ME2yJO69VQ>? NGPlT24yPTdzNUS3NC=>
SNB-78 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrJOFghcA>? MYnJR|UxRTF4IN88US=> MY[xOVcyPTR5MB?=
St-4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrkXVQ1QCCq MnzFTWM2OD13LkKg{txO NGPv[mYyPTdzNUS3NC=>
ARP1 M4PIXmZ2dmO2aX;uJGF{e2G7 NF\WVGQzKM7:TR?= MUC2JIg> M1Tuemlv\HWldHnvckBw\iCSMkHXRWYyKGenbnWg[ZhxemW|c3nvci=> MmLHNVQ4OzR6ME[=
CEM M{HIUGtqdmG|ZTDBd5NigQ>? MnL4NUBp M3rv[2ROW09? Mn:yTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? MnfhNVY1OjByNkS=
HCT15 NXi5eWt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PQW|Q5KGh? NXzKVnFET0l3ME2wMlgzKM7:TR?= NEHINVAyPjd{M{KyOy=>
NCI-H23 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoS2OFghcA>? MUnHTVUxRTBwOUKg{txO M4nkN|E3PzJ|MkK3
GM15850 MlLUT4lv[XOnIFHzd4F6 NWfCSXhXOi53IN88US=> NUXnbZkxQTZiaB?= MkfnSG1UVw>? MWfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MmGzNVY6OjF|Nke=
GM15850 MVrLbY5ie2ViQYPzZZk> NYDJ[GJpOi53IN88US=> MnHaPVYhcA>? NXrYS244TE2VTx?= NFLqXW5KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MmXxNVY6OjF|Nke=
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GM15850 MUXLbY5ie2ViQYPzZZk> NWf5WlJtOi53IN88US=> NUDsU5Q5QTZiaB?= NESwNVlFVVOR MlywTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3zqWVE3QTJzM{[3
GM15850 NVXVUGZQU2mwYYPlJGF{e2G7 M{XTUVIvPSEQvF2= NV7rbGhkQTZiaB?= M17IO2ROW09? Mn\kTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? M3vqXlE3QTJzM{[3
GM15850 NF\pVGhMcW6jc3WgRZN{[Xl? MkGyNk42KM7:TR?= MYC5OkBp M4rn[WROW09? NHjwdnFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MkXlNVY6OjF|Nke=
U937 MX3GeY5kfGmxbjDBd5NigQ>? NUTYSnZIPSEQvF2= NVjRbmQyOjRiaB?= MUDEUXNQ NIe4cZVE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn NF\NdGcyPzByNEexPC=>
H661 MnXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHPN2pGPDhiaB?= MnraTWM2OD1zIN88US=> NFHub|YyPzF3N{CwPS=>
U937 MXHGeY5kfGmxbjDBd5NigQ>? MUS1JO69VQ>? NH;yVXEzPCCq MXjEUXNQ MlnOTY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= NVXKUXJzOTd2NEe3OVA>
U937 NYHB[po{TnWwY4Tpc44hSXO|YYm= Ml7XNUDPxE1? MX2yOEBp MX;EUXNQ NWPiUJRRTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> NF3JXXEyPzR2N{e1NC=>
RAW264.7 M3nMNWZ2dmO2aX;uJGF{e2G7 NEHsXlcyOCEQvF2= NXfYXGxvOjSq NILxdHh4[XSnch?= M3rTdWlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE44PiEQvF2= MVKxO|Q4PzVzOB?=
RAW264.7 MUjGeY5kfGmxbjDBd5NigQ>? MXWxNEDPxE1? NGjZWIEzPGh? M1XCOpdifGW{ MYDJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFEvQDhizszN MlH1NVc1Pzd3MUi=
SC9 M2W3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\KOFghcA>? M2fnN2lEPTB;MD62NFYh|ryP MVGxO|UxPzJzOR?=
ST14A MU\GeY5kfGmxbjDBd5NigQ>? NWTGTZUzPSCwTR?= MnLFO|IhcA>? NV;keXdxUW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? MlfoNVc2PjV7OUO=
ST14A MlWySpVv[3Srb36gRZN{[Xl? MmjSOUBvVQ>? M{foPFczKGh? NEfLWGtKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= MlvWNVc2PjV7OUO=
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PANC1 NITGWppHfW6ldHnvckBCe3OjeR?= MlLINUDPxE1? MU[yOEBp M3f3Tmlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u MnfNNVc2QDh5NES=
PT45 MmCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDP[JhKSzVyPUSg{txO NEjCRYoyPzV6OEe0OC=>
ACHN NFTjVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjxNlEhcA>? MVXHTVUxRTBwNkWg{txO NX[4NlJPOTd4NkK2NFY>
PC3 NVHFfItQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjTeowzOSCq MnX3S2k2OD1yLkexJO69VQ>? NFGzcGcyPzZ4Mk[wOi=>
A431 M3jIXWN6fG:2b4jpZ{BCe3OjeR?= Mk\IO|IhcA>? M2jMR2lEPTB;ND6yJO69VQ>? MXGxO|Y6OTd4Mx?=
Cal27 MXfDfZRwfG:6aXOgRZN{[Xl? NGDOSoc4OiCq NELDXmZKSzVyPUOuNkDPxE1? M{nZcFE4PjlzN{[z
CCRF-CEM M2f5ZmN6fG:2b4jpZ{BCe3OjeR?= NEjXcnc4OiCq NED5WmNKSzVyPUCuPEDPxE1? NFjWTXMyPzZ7MUe2Ny=>
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Hec-1-A M{C5SGN6fG:2b4jpZ{BCe3OjeR?= NHrKc5U4OiCq MX7JR|UxRTFizszN M2rtOVE4PjlzN{[z
HeLa NHrvWpRMcW6jc3WgRZN{[Xl? NYfDdVd6OTBizszN M4DSRlMxKG2rbh?= NUfSd4lXTE2VTx?= NIHBfI9KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGhFSUNzIIfpeIghUUN3MDDv[kAxNjB{IN88US=> MnzJNVc3QTF5NkO=
RKOp21 NW\CcFVRS3m2b4TvfIlkKEG|c3H5 NXfRXG02PzJiaB?= MXTJR|UxRTFwN{[g{txO MnTtNVc3QTF5NkO=
Saos2 NELhemVEgXSxdH;4bYMhSXO|YYm= M3\wVFczKGh? NGPkVWdKSzVyPUKuN{DPxE1? NWTXb5pUOTd4OUG3OlM>
SK-OV-3 MWDDfZRwfG:6aXOgRZN{[Xl? MoS2O|IhcA>? Mn;iTWM2OD1{LkKg{txO M4XMTlE4PjlzN{[z
U87MG MVLDfZRwfG:6aXOgRZN{[Xl? MmrBO|IhcA>? M4P2XWlEPTB;MUGg{txO M1vYdVE4PjlzN{[z
NUGC3 NUn3bIlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1niU|Uh|ryP M4W2[FI1KGh? MnTRS2k2OD1{Lke5JO69VQ>? M{TwbFE4QTB2OESz
CCD1059SK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\5TWM2OD12Mz61JO69VQ>? M3zDOVE5OjR5NUW0
HepG2 M3rPTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwMECwOkDPxE1? MlPnNVgzPDd3NUS=
HT1080 M{XGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTqfYRVUUN3ME2wMlAxOjRizszN NVSzXZVXOTh{NEe1OVQ>
SKBR3 M2fJOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHEfIlKSzVyPUCuPEDPxE1? MlrxNVgzPDd3NUS=
SNB78 NF61bZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnSV3Z1TUN3ME2xOkDPxE1? NFTHOVgyQDJ2N{W1OC=>
SQ20B MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGx[W0zUUN3ME2zJO69VQ>? NXLIb3BzOTh{NEe1OVQ>
St4 NYD4dotET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jUfWVEPTB;NT6yJO69VQ>? MkXqNVgzPDd3NUS=
MCF7 NVvJT2cxTnWwY4Tpc44hSXO|YYm= MWSxNEDPxE1? NYe2SYFHQCCq NIDhcZpFVVOR NGTLNVhKdmS3Y4Tpc44hd2ZidIXieYxqdiCqeYDldoFk\XS7bHH0bY9v NXH6fZdQOTh{NkmyNlY>
HEK293 NUTFclRGU2mwYYPlJGF{e2G7 NGHYeIMyKGh? MoLnSG1UVw>? MmLkTY5pcWKrdHnvckBw\iCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6wN{DPxE1? M1z2NFE5OzB6NU[z
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U937 NHPIbItHfW6ldHnvckBCe3OjeR?= NFm1U4o2KM7:TR?= M3XiS|I1KGh? MnXpTY5lfWO2aX;uJI9nKGirc4TvcoUhUDRiaInw[ZJi[2W2eXzheIlwdg>? NEHwZVMyQDN6MUKzPC=>
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U937 NGPyUFZHfW6ldHnvckBCe3OjeR?= M3fZNlUh|ryP M{L0dFI1KGh? NWnXbIN5UW6mdXP0bY9vKG:oIICyNUBmgHC{ZYPzbY9v NYq1RpZTOTh|OEGyN|g>
U937 MWLGeY5kfGmxbjDBd5NigQ>? MmLSOUDPxE1? Ml7SNlQhcA>? NIrBcnNKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| M3HxZlE5OzhzMkO4
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U937 Mn3YT4lv[XOnIFHzd4F6 NVjyVWNOPSEQvF2= NYjt[5Z5OjRiaB?= NGr6TmZKdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOx M13CN|E5OzhzMkO4
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Human microvascular epithelial cell M{\QfmN6fG:2b4jpZ{BCe3OjeR?= MUC1NEDPxE1? MXy3NkBp NITEXXBFVVOR M1H5U2lEPTB;MT6zJO69VQ>? MWixPFQ6PDR4Mx?=
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Panc 04.03 NV3ITZVjS3m2b4TvfIlkKEG|c3H5 MnLGOVAh|ryP M4P2TlczcA>? MWPEUXNQ M1PscWlEPTB;MT6yJO69VQ>? M4DlPFE5PDl2NE[z
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NB4 MX:0PIg> NVK2O4l[TE2VTx?= MU\JR|UxRTBwNjFOwG0> NUDQXpBHOTh5MkOzOFk>
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Sf21 M1O0OmtqdmG|ZTDBd5NigQ>? MljoN{Bp MUnJcohq[mm2aX;uJI9nKE[uYXegeIFo\2WmIHj1cYFvKHKnY3;tZolv[W62IFjERWM5KGW6cILld5Nm\CC5aYToJGlEPTBib3[gNU4zKM7:TR?= NY[1b2dCOjFyOEC2Nlk>
SKBR3 M33xTGN6fG:2b4jpZ{BCe3OjeR?= NX;we2lGPzJiaB?= MkfqR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= M{LnZVIyODhyNkK5
SKOV3 MmToR5l1d3SxeHnjJGF{e2G7 NVz3fI03PzJiaB?= M3n4SGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= NVPReoxuOjFyOEC2Nlk>
COR-L23 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW5fmIyOCEQvF2= NVfmUVZPPzJiaB?= NUiyZpRmTE2VTx?= M{HFOmdKPTB;MT6xJO69VQ>? MYKyNVA5ODZ2Nx?=
DU145 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fTclExKM7:TR?= NEjjOW04OiCq M2S0N2ROW09? MnThS2k2OD1zLkC1JO69VQ>? Mln2NlExQDB4NEe=
LoVo NYDoPYdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXQNVAh|ryP M4\tV|czKGh? MYTEUXNQ MkX4S2k2OD1zLkeg{txO NVfEWVBtOjFyOEC2OFc>
MCR5-SV2 M3\xUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDpOWNbOTBizszN MWi3NkBp NFvPTVdFVVOR MXPHTVUxRTJwMTFOwG0> MWqyNVA5ODZ2Nx?=
HCT116 MmnET4lv[XOnIFHzd4F6 MUmzNEDPxE1? NH\OOFg{OCCq Ml;XSG1UVw>? MknyTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NYK0XmZ{OjFyOEC2OFc>
HCT116 M2HSTGtqdmG|ZTDBd5NigQ>? NWrhUGI{OzBizszN M2i4UVMxKGh? NX\4flY2TE2VTx?= NXLRVVZuUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u M3vOcFIyODhyNkS3
U937 NXHqVVd2U2mwYYPlJGF{e2G7 M1jjdFUh|ryP Mn23NlQhcA>? MUXEUXNQ NYnsdlMxUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= MXOyNVI6OjR7Mh?=
U937 MW\LbY5ie2ViQYPzZZk> MnTZOUDPxE1? NY\GWZh7OjRiaB?= NVzmVZd4TE2VTx?= NUjrN4J4UW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 MnvVNlEzQTJ2OUK=
U937 NVTSNYl2U2mwYYPlJGF{e2G7 M2LqfFUh|ryP MmftNlQhcA>? NXzOfYJETE2VTx?= NH7nN3ZKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= NWDpUXlXOjF{OUK0PVI>
U937 MYTLbY5ie2ViQYPzZZk> NYHOO|RCPSEQvF2= MYCxOUBucW5? NFi1XpBFVVOR M2LvR2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIHzleoVt M1TYe|IyOjl{NEmy
A2780 Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vEWFk3KGh? NXmw[Xl6TE2VTx?= MWHJR|UxRTFwNkKg{txO NHvtVWozOTZ|NESzNC=>
COLO205 NWTxVFdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLlPVYhcA>? MVfEUXNQ M4SzSmlEPTB;Mj6xNkDPxE1? Mn3ENlE3OzR2M{C=
Hep3B MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfzdJRPPDhiaB?= Mn;rSG1UVw>? NWLaN49RT0l3ME2xMlIyKM7:TR?= M3XKbFIyPzF{MUS2
GM11272 Mn\ySpVv[3Srb36gRZN{[Xl? M{mwflExOCCwTR?= NWnaPHd7PzJiaB?= M4C0TWROW09? MYTS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N Mo\hNlE5PDB5MU[=
CFBE41o M33ZcmtqdmG|ZTDBd5NigQ>? MkXGOUDPxE1? NHzHeW9FVVOR MkS1SI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO MW[yNVk5PDl3OB?=
CFBE41o MVjGeY5kfGmxbjDBd5NigQ>? M1nITFEh|ryP M{jkUlI1KGh? MYfEUXNQ NHv0UI9T\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= MX6yNVk5PDl3OB?=
DU145 M3jvT2tqdmG|ZTDBd5NigQ>? NUD2NZVKOi53IN88US=> MUeyOEBp NWexdZRpTE2VTx?= MUfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u MoL0NlIzPjBzNk[=
DU145 M{LxfmtqdmG|ZTDBd5NigQ>? NHTKOpM2KM7:TR?= NVzxWldSOjRiaB?= NXTHbIJYTE2VTx?= M4DmeWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u M1XYc|IzOjZyMU[2
DU145 NV3mTJJvU2mwYYPlJGF{e2G7 MVe1JO69VQ>? MkDnNlQhcA>? MlP3SG1UVw>? NXPk[nF1UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= NFLn[IczOjJ4MEG2Oi=>
786-0 NWi5WG5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTPOk4zKM7:TR?= MYK3NkBp NFPTVm5FVVOR M4jCeGdKPTB;Mz6yJO69VQ>? NXK2eYx1OjJ2M{W2Olk>
A498 Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXmZWJ[Pi5{IN88US=> Mn;oO|IhcA>? NUHuOII3TE2VTx?= NHLCe|BIUTVyPUGuOkDPxE1? M2q2RVIzPDN3Nk[5
A549/ATCC NIroPIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLNb4c3NjJizszN NF\3dnE4OiCq M2rVZ2ROW09? NVHXbpJST0l3ME2xMlYh|ryP MUKyNlQ{PTZ4OR?=
ACHN NVfuSYlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVG2MlIh|ryP NWnWUFhPPzJiaB?= NEGzPGhFVVOR NWH6Z3d3T0l3ME2xMlMh|ryP MUGyNlQ{PTZ4OR?=
BT549 NXfPPJZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M135dFYvOiEQvF2= Mn3xO|IhcA>? M2DB[mROW09? NFPPeIVIUTVyPUGuN{DPxE1? MXyyNlQ{PTZ4OR?=
EKVX MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXu2MlIh|ryP NUHOdIQ5PzJiaB?= MlfWSG1UVw>? M{PRe2dKPTB;MT6zJO69VQ>? NU\5U|BqOjJ2M{W2Olk>
HCT15 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TiV|YvOiEQvF2= MoC2O|IhcA>? NUXrTGRtTE2VTx?= NIfBcFdIUTVyPUKuOUDPxE1? NX;SeHhLOjJ2M{W2Olk>
HOP92 MoPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYm2MlIh|ryP MYW3NkBp NHqzTXJFVVOR M2PsXWdKPTB;NDFOwG0> MlLrNlI1OzV4Nkm=
IGROV1 NIHpbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7M[ppFPi5{IN88US=> NVjVN4d4PzJiaB?= NEGybJpFVVOR MoT6S2k2OD1zLkOg{txO NXz1bZppOjJ2M{W2Olk>
LOXIMVI MoPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ezflYvOiEQvF2= M{S4OlczKGh? NYDVe254TE2VTx?= MmXXS2k2OD1zIN88US=> NETpRmYzOjR|NU[2PS=>
M14 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfYOk4zKM7:TR?= NGrNTJo4OiCq NF3sbIFFVVOR MlO4S2k2OD1zLkOg{txO NECwdIMzOjR|NU[2PS=>
MALME-3M MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXTN21LPi5{IN88US=> MnTVO|IhcA>? MljjSG1UVw>? NVfOPJp6T0l3ME2wMlMzKM7:TR?= NIXSNZAzOjR|NU[2PS=>
MCF10A NEXFVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjx[3lSPi5{IN88US=> NHPkVVM1QCCq M2DoWWROW09? MkHhS2k2OD17Lk[g{txO NVOyTGRuOjJ2M{W2Olk>
MDA-MB-435 NFnUfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv0UpE3NjJizszN MlzaO|IhcA>? M2LPXWROW09? NIC0dIFIUTVyPUCuOUDPxE1? MmD2NlI1OzV4Nkm=
MDA-MB-468 M1PLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13GelYvOiEQvF2= NIO1SGk4OiCq NYPmcFBwTE2VTx?= MYjHTVUxRTBwNkOg{txO NILnZVYzOjR|NU[2PS=>
MOLT4 NWH5OpVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWK2MlIh|ryP MUK3NkBp NX;LSlRVTE2VTx?= MVfHTVUxRTBwNDFOwG0> M1:3fVIzPDN3Nk[5
NCI-ADR-RES NHfvfIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL5Sow5Pi5{IN88US=> MV63NkBp MkTsSG1UVw>? NGXBWWRIUTVyPUCuNVYh|ryP MYiyNlQ{PTZ4OR?=
NCI-H23 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvndXRFPi5{IN88US=> MmLxO|IhcA>? MYXEUXNQ M{nGW2dKPTB;MTFOwG0> NVvB[mhMOjJ2M{W2Olk>
NCI-H322M MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PxNFYvOiEQvF2= NIS2b5I4OiCq NV;EfW9LTE2VTx?= NIn6V4FIUTVyPUCuO|kh|ryP Mny4NlI1OzV4Nkm=
NCI-H460 M3TjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[1NlYvOiEQvF2= NG\yNGE4OiCq M2G5WWROW09? M{HyRmdKPTB;MD63PUDPxE1? Mn7WNlI1OzV4Nkm=
NCI-H522 NIrjd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm1dWY3NjJizszN M2nLXlczKGh? MYrEUXNQ M4S4WWdKPTB;MD61JO69VQ>? MoHZNlI1OzV4Nkm=
OVCAR3 M2q4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;MW|YvOiEQvF2= NFu4WFY4OiCq NFHySo9FVVOR M4Ll[GdKPTB;MT6zJO69VQ>? NYLkVm5zOjJ2M{W2Olk>
OVCAR4 M{PpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzHOk4zKM7:TR?= Mo\HO|IhcA>? MVLEUXNQ NULWSYo6T0l3ME20JO69VQ>? MUmyNlQ{PTZ4OR?=
OVCAR5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPaOk4zKM7:TR?= NHPyV2E4OiCq NW\NclU3TE2VTx?= MYfHTVUxRTBwN{mg{txO MWWyNlQ{PTZ4OR?=
OVCAR8 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[2MlIh|ryP NFTUT5c4OiCq NGjvSJpFVVOR MYXHTVUxRTBwNTFOwG0> M2\YW|IzPDN3Nk[5
RXF393 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXW2MlIh|ryP MVK3NkBp NU\IfWtJTE2VTx?= M3nYUGdKPTB;MT6zJO69VQ>? Mk[3NlI1OzV4Nkm=
SF268 NWDHVpR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi2OlU6Pi5{IN88US=> M3iwUVczKGh? NYPXOHNmTE2VTx?= NFPqfnVIUTVyPUGuOkDPxE1? M3H1TFIzPDN3Nk[5
SF295 M2jUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj3SmZJPi5{IN88US=> NGDxblA4OiCq NWH5[GdGTE2VTx?= MWDHTVUxRTFwNjFOwG0> NFrrXnYzOjR|NU[2PS=>
SF539 M2HQO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjaPGQ3NjJizszN NFLYWpg4OiCq M4DObmROW09? NIrtZotIUTVyPUKg{txO Mk\1NlI1OzV4Nkm=
SK-MEL-2 NIrtSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLGOk4zKM7:TR?= NIPiNmg4OiCq NVXsd2lvTE2VTx?= MnfXS2k2OD1zLkOg{txO MUmyNlQ{PTZ4OR?=
SK-MEL-28 M4mxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[1Ok4zKM7:TR?= NGLpWVc4OiCq NXzY[llsTE2VTx?= M4PiPGdKPTB;MTFOwG0> NInnTlczOjR|NU[2PS=>
SK-MEL-5 M2DH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrqUINJPi5{IN88US=> NXTTWphpPzJiaB?= MVnEUXNQ NGezNJlIUTVyPUCuOlMh|ryP Mke5NlI1OzV4Nkm=
SKOV3 NFfKOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzFOk4zKM7:TR?= NID3SXk4OiCq M173TmROW09? MYHHTVUxRTFizszN NVfTV4NZOjJ2M{W2Olk>
SN12C NVfBbY9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLNOk4zKM7:TR?= M3;KSVczKGh? NGfqWZRFVVOR M4jqeWdKPTB;MjFOwG0> NVXhbGNPOjJ2M{W2Olk>
SNB19 NVLlclA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PD[VYvOiEQvF2= NFfkdo84OiCq M4jjO2ROW09? Mn;6S2k2OD1yLk[zJO69VQ>? NIDidZIzOjR|NU[2PS=>
SNB75 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT6Ok4zKM7:TR?= NEnZPWc4OiCq NH\KU4lFVVOR NHewPZJIUTVyPUCuO|kh|ryP NVfJUGRtOjJ2M{W2Olk>
SR NHfwTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXPZmc3NjJizszN MVu3NkBp NETpflFFVVOR NVu1PZVkT0l3ME2wMlQh|ryP M4W2UlIzPDN3Nk[5
T47D MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDxfG43NjJizszN MVO3NkBp Ml61SG1UVw>? MWHHTVUxRTBwNTFOwG0> NFjXN|gzOjR|NU[2PS=>
TK10 NV7yVXZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;KOk4zKM7:TR?= NEe5NWM4OiCq M37ZemROW09? M{H6R2dKPTB;MD62N{DPxE1? NFexNJQzOjR|NU[2PS=>
UACC257 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUm2MlIh|ryP MVS3NkBp NI\MNFVFVVOR MmPES2k2OD1yLkWg{txO MV6yNlQ{PTZ4OR?=
UACC62 M{DF[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXG2MlIh|ryP MVy3NkBp Mm\pSG1UVw>? NWrhT4hwT0l3ME2wMlQh|ryP Mlm5NlI1OzV4Nkm=
UO31 NXHlVG1VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHac|dxPi5{IN88US=> NVvhVIFCPzJiaB?= Mn3xSG1UVw>? NGnzSYZIUTVyPUCuOUDPxE1? NXOzSZFsOjJ2M{W2Olk>
Hep3B NVq3THR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TGflQ5KGh? NI\0NJdFVVOR M2jkVWdKPTB;MD62PUDPxE1? NVTsOVZwOjJ2M{m4OlM>
BE(2)-C NUnIZY5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn64O|IhcA>? M3e0ZmROW09? MYHJR|cxRTJizszN NVK1fHFuOjJ7M{KzNVY>
Bel7402 NHzuSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX63NkBp NH3lWYdFVVOR MlfVS2k6OD1zNzFOwG0> MlL2NlMxPjF|N{[=
Bel7404 NVfWNIcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm0[WpWPzJiaB?= MWXEUXNQ NFvne|FIUTlyPUG4JO69VQ>? NVfsUHc1OjNyNkGzO|Y>
BGC823 M2qwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnnfI04OiCq M3\hNWROW09? M1;JdGdKQTB;Nz61JO69VQ>? M4TESlI{ODZzM{e2
MGC803 NYnX[2k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3vRlhlPzJiaB?= M4jCVmROW09? MYrHTVkxRTFyLkig{txO MXSyN|A3OTN5Nh?=
SGC7901 MmTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPUeXQ4OiCq MWTEUXNQ MXrHTVkxRTlwNDFOwG0> NWTrS2tFOjNyNkGzO|Y>
SKHEP1 NVnnO2RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Pu[lczKGh? NYnZS4R7TE2VTx?= NWXE[GpST0l7ME2xO{DPxE1? NVvBZVNmOjNyNkGzO|Y>
SMMC7721 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\MNVczKGh? M2PjSGROW09? MnzuS2k6OD1{MDFOwG0> M3TlO|I{ODZzM{e2
NUGC3 NEDKXHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrsNVAh|ryP NHHkNlJIUT1{Lkm0JO69VQ>? NEfUZ4czOzF4M{OzNi=>
A2780 CisR NWDROWt6U2mwYYPlJGF{e2G7 NWrRXWZXOThiaB?= MmDSTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkS0JO69VQ>? NH3GZ3IzOzJ3Mk[wNy=>
CAL27 sens MYPLbY5ie2ViQYPzZZk> MkHmNVghcA>? NYrIUHc6UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= M1TmbVI{OjV{NkCz
CAL27 CisR MlXpT4lv[XOnIFHzd4F6 M2LCbVE5KGh? NXPGSJFZUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= M4DsSVI{OjV{NkCz
KYSE-510 CisR NEe3d5ZMcW6jc3WgRZN{[Xl? M3j6PVE5KGh? M1rhZ2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? NUW5NoxmOjN{NUK2NFM>
KYSE-510 sens NFfTRW9McW6jc3WgRZN{[Xl? M3PQPVE5KGh? MWPJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> NXHDOJdNOjN{NUK2NFM>
MDA-MB-231 sens M4nFdmtqdmG|ZTDBd5NigQ>? M2TNZ|E5KGh? M1XWN2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? MkfMNlMzPTJ4MEO=
MDA-MB-231 CisR M4LBW2tqdmG|ZTDBd5NigQ>? MXqxPEBp MYTJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO M{XmTlI{OjV{NkCz
ES2 NGDiUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF76PGY1QCCq MYfEUXNQ MVfJR|UxRTF{Lkeg{txO M1zOWVI{PDl|NES5
MDA-MB-231 M3jtfmtqdmG|ZTDBd5NigQ>? NFmzV20yOCEQvF2= MnrjN|AhdWmw MUPEUXNQ NGHmWoNKdmirYnn0bY9vKG:oIFjERWMz[Q>? M{L2VlI{PDl|NES5
MDA-MB-231 NXfOeo5FU2mwYYPlJGF{e2G7 MYixJO69VQ>? MX[yOEBp MYnEUXNQ MVnJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NVfDS|h1OjN2OUO0OFk>
HS68 M3raT2N6fG:2b4jpZ{BCe3OjeR?= NHnCOFEyOCEQvF2= NVvISpJnPzJiaB?= NXjNWoxUTE2VTx?= M131TmlEPTB;ND62JO69VQ>? M4PXc|I{PTdyNUSy
MEF NWO5SJVOS3m2b4TvfIlkKEG|c3H5 MWKxNEDPxE1? M1TQdFczKGh? NYj3fGRETE2VTx?= MlzxTWM2OD12LkSg{txO NVPCfXpqOjN3N{C1OFI>
BGC823 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzPWHBFVVOR M2TycGdKPTB;Mz6wPUDPxE1? M4LCfFI{PjBzN{C2
High5 NEDNVFhMcW6jc3WgRZN{[Xl? M1viW|I1KGh? M3vRXWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP MXWyN|YxOjV{Mx?=
High5 M2XFZWtqdmG|ZTDBd5NigQ>? NHexe|AzPCCq NYjnN41[UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= NF\lWmMzOzZyMkWyNy=>
High5 NGnCZ25McW6jc3WgRZN{[Xl? NV3KW2h1OjRiaB?= NInXWmdKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= MYqyN|YxOjV{Mx?=
A549 NFvKeWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfnSY1FVVOR NHjqPWxKSzVyPUGuNFc6KM7:TR?= NWKxTnVWOjN4NESyNVA>
HCT116 NWrkOZZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HSRmROW09? NXvvSm5JUUN3ME2wMlc2PyEQvF2= NYqwcIdCOjN4NESyNVA>
K562 NGLUVnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml63SG1UVw>? M1jufmlEPTB;MD62OFUh|ryP NYXPfnEyOjN4NESyNVA>
GBC-SD NGKzOnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX4OUDPxE1? MXK3NkBp M2nHfmROW09? MVrJR|UxRTF2Lkig{txO M3\mdlI{PzB5Mk[w
HGC27 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXZPJM2KM7:TR?= NV;TVHE1PzJiaB?= MlL0SG1UVw>? NVPES5hwUUN3ME21MlQh|ryP NUXtdm15OjN5MEeyOlA>
HL60 NFrlZYlMcW6jc3WgRZN{[Xl? M3P6VlUh|ryP NIPlcW8zPCCq M1\0NWROW09? Mki4TY5pcWKrdHnvckBw\iCKRFHD NUfydWEzOjN5MEeyOlA>
Vero MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH3d3pEPzJiaB?= Ml;qSG1UVw>? NU[3[nc3UUN3ME2wMlkh|ryP MVOyN|c5PjR3Mh?=
NCI60 MUfDfZRwfG:6aXOgRZN{[Xl? M1i3blQ5KGh? NYjWbYhJTE2VTx?= MkHzS2k:OC53MzFOwG0> MlLLNlQxOTV|Mke=
SW620 MnXjR5l1d3SxeHnjJGF{e2G7 MVi0PEBp NEjkbHhFVVOR NXzJS4VQT0l;MD61OEDPxE1? MX6yOFAyPTN{Nx?=
U251 MoHRR5l1d3SxeHnjJGF{e2G7 NHTH[3M1QCCq MoT4SG1UVw>? NHrYNIFIUT1zLkWzJO69VQ>? NYDzbm9mOjRyMUWzNlc>
KM12 MVzDfZRwfG:6aXOgRZN{[Xl? NVvPPWNSPDhiaB?= M363[WROW09? NGTXZVBIUT1zLki4JO69VQ>? NIKycY8zPDBzNUOyOy=>
Hs578T MWjDfZRwfG:6aXOgRZN{[Xl? M3zoTVQ5KGh? M1fBdWROW09? NXu0N4N[T0l;ND64N{DPxE1? Mn3jNlQxOTV|Mke=
MDA-MB-231 M{i1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXja[ZI6PDhiaB?= NIf2[2xKSzVyPUCuNVYh|ryP Mn6wNlQxQTVyMU[=
MCF7 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXBfFA1QCCq MnS4S2k:OC52NTFOwG0> MYOyOFEyQTV3NR?=
MDA-MB-435 MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfMOFghcA>? M2faSWdKRTBwOEig{txO NYTJVoxKOjRzMUm1OVU>
AsPC1 NGDsTY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnEZYE{OCEQvF2= NEDzZY01QCCq M124WGROW09? MWPJR|UxRTNwNk[g{txO MW[yOFE5PTN5OB?=
Jurkat E6.1 NXzneJJvU2mwYYPlJGF{e2G7 NH\F[2ozKGh? NFHuR4JFVVOR NYHCZpBnUW6qaXLpeIlwdiCxZjDISGFEPCC5aYToJGlEPTBib3[gNE4xPCEQvF2= Mm\lNlQzPjF6NkK=
KG1 MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HwR|Q5KGh? Mn;mTWM2OD1zLkG1JO69VQ>? M1z4dlI1PTJ3MECz
HEL M4D3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnERVE1QCCq MV3EUXNQ NYjPSIg3UUN3ME2wMlQ6KM7:TR?= NYD1XFdZOjR4OUSwOVU>
HSC3 NGq4UZJEgXSxdH;4bYMhSXO|YYm= Mmn1NVIhcA>? MkH6SG1UVw>? NETqeoVKSzVyPUCuO|Eh|ryP MnfNNlQ4PjZ3NkC=
HT-29 Mkj1R5l1d3SxeHnjJGF{e2G7 MUexNkBp M2PoZWROW09? MXzJR|UxRTBwN{Kg{txO NGTCXIgzPDd4NkW2NC=>
KB NITDNXREgXSxdH;4bYMhSXO|YYm= Mlq3NVIhcA>? NXjldHBOTE2VTx?= M3zNcmlEPTB;MD63OUDPxE1? M4\4WlI1PzZ4NU[w
H460 NFL3TotEgXSxdH;4bYMhSXO|YYm= MXuxNkBp NWfiUI9ZTE2VTx?= NF[0SpZKSzVyPUCuPFIh|ryP Mn7sNlQ4PjZ3NkC=
MONE1 NGDpZ2hEgXSxdH;4bYMhSXO|YYm= MXSxNkBp NFK5V2ZFVVOR NF;wdlhKSzVyPUGuNVgh|ryP M2LsbFI1PzZ4NU[w
MKN45 NUPuUJoxS3m2b4TvfIlkKEG|c3H5 MYCxNkBp MoDDSG1UVw>? NHPMeo5KSzVyPUGuNlUh|ryP MkDKNlQ4PjZ3NkC=
TSGH NWjld|dCS3m2b4TvfIlkKEG|c3H5 NX;3bHd{OTJiaB?= NW\5[|MzTE2VTx?= M2DXOmlEPTB;Mj6wPUDPxE1? MUCyOFc3PjV4MB?=
HL60 NFPTc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO3NkBp M4nqT2ROW09? NX64WZljT0l3ME2wMlk{KM7:TR?= M1rmVFI1QTByNUCw
HEK293 NUDneG93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVi3NkBp Mm\wSG1UVw>? Ml\ZS2k2OD1zMzFOwG0> MlmxNlQ6ODB3MEC=
Jurkat NELXOlZEgXSxdH;4bYMhSXO|YYm= NVTyeHUzOTByIN88US=> MXS3NkBp NXvCOm9pT0l3ME2wMlkh|ryP M3TrWVI1QTByN{Sz
GM15850 NUTDR5RlU2mwYYPlJGF{e2G7 MmLsNk42KM7:TR?= NHXlemw6PiCq MUPEUXNQ Ml7U[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NGDzUoMyPjl{MUO2Oy=>
GM15850 NWf5[WVHU2mwYYPlJGF{e2G7 MV:yMlUh|ryP MnnJPVYhcA>? M2TKfmROW09? NX;nV2V3\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDViYXPleJlt[XSrb36gc4YhTliQIHflcoU> MWOxOlkzOTN4Nx?=
GM15850 MVzLbY5ie2ViQYPzZZk> NVLDTItXOi53IN88US=> NEmyOlY6PiCq NHfPcmFFVVOR NE\vUohld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTJiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NV3oTFM{OTZ7MkGzOlc>
GM15850 M4PHZmtqdmG|ZTDBd5NigQ>? MlvCNk42KM7:TR?= NH[w[Gw6PiCq MXnEUXNQ NHzpbmNld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NV\2UphjOTZ7MkGzOlc>
GM15850 MonWT4lv[XOnIFHzd4F6 MWiyMlUh|ryP NVzTOIxsQTZiaB?= M1zyUGROW09? M2nvVoRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA5KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NVHFVJBkOTZ7MkGzOlc>
GM15850 M3jtd2tqdmG|ZTDBd5NigQ>? NYrIVYNHOi53IN88US=> MUO5OkBp MlH0SG1UVw>? NU\LcVl5\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF4IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m NHXxW4cyPjl{MUO2Oy=>
GM15850 M4DS[2Z2dmO2aX;uJGF{e2G7 MmezOUDPxE1? Mm\3NVIhcA>? MVfEUXNQ NIDGTY1p[XNibn:g[YZn\WO2IH;uJGZZViCvUl7BJIV5eHKnc4Ppc44> NX;5cnRbOTZ7MkGzOlc>
U937 MX7LbY5ie2ViQYPzZZk> MUm1JO69VQ>? M2jmVFI1KGh? NVexSI0xTE2VTx?= M4T1UYhieyCwbzDl[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= MYCxO|Q1Pzd3MB?=
U937 NFL2OJdMcW6jc3WgRZN{[Xl? NIm3c5QyKM7:TR?= NEPEWmMzPCCq MlnaSG1UVw>? NVT0bXhXcGG|IH7vJIVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u NGWyWIQyPzR2N{e1NC=>
PANC1 MVnGeY5kfGmxbjDBd5NigQ>? M2HxdFEh|ryP NEDQVpMzPCCq NIjBSmhld2W|IH7veEBqdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> MoeyNVc2QDh5NES=
PANC1 M1zCS2Z2dmO2aX;uJGF{e2G7 NYDndXdCOSEQvF2= MmnIOFghKGh? NVT0d5pn\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> M1fvXlE4PTh6N{S0
Caco-2 MV7GeY5kfGmxbjDBd5NigQ>? NX7BdZU{PSEQvF2= M{nmTFI1KGh? MX3EUXNQ M2XmU4Rw\XNibn;0JIlv\HWlZTDQNlFYSUZzIHflcoUh\XiycnXzd4lwdg>? NFr6WIIzODF2M{i0NC=>
SCC4 MnfvSpVv[3Srb36gRZN{[Xl? MnjBNUDPxE1? NW\2UVVrOTBibXnu NWrxcGlUTE2VTx?= MX7oZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? NEizPW0zODR3MkKyOS=>
A549 NUPXelRMTnWwY4Tpc44hSXO|YYm= MX21JO69VQ>? M2j0[|MhcA>? NWrEbFh[TE2VTx?= MUHkc4V{KG6xdDDpcoR2[2ViYYX0c5Bp[We7IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEyFM1nJ MVOyNFg2PTJyOB?=
HCT116 MWnLbY5ie2ViQYPzZZk> NGexNY8xNjNizszN NVjs[nRuOzBiaB?= MnLoSG1UVw>? M2ThZ4Rw\XNibn;0JIlvcGmkaYSgTGRCSzFiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGirc4TvcoUhUDONOTDhZ4V1gWyjdHnvci=> MmDTNlExQDB4NEe=
HepG2 NVrzVoh4TnWwY4Tpc44hSXO|YYm= M4TtSFExKM7:TR?= MWGyOEBp MXXEUXNQ Mnvp[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BpgXCncnHj[ZR6dGG2aX;uJI9nKHB3Mx?= NEDuR4YzOTV2OEW4Ni=>
GM11272 M2j5WGZ2dmO2aX;uJGF{e2G7 NWWz[2l5OC5zIN88US=> NVnwRmxGPzJiaB?= M3vqWWROW09? NWnzXHZM\G:nczDuc5QhemWjY4TpeoF1\SCPZVPwNkBufXSjboSg[ZhxemW|c3nvci=> NGH6cWwzOTh2MEexOi=>
MDA-MB-231 NVXIe3BQU2mwYYPlJGF{e2G7 NHK3VnIyOCEQvF2= MXy1JI1qdg>? M3r6Z2ROW09? MorI[I9meyCwb4SgbY5pcWKrdDDISGFEOmF? NHjxTXEzOzR7M{S0PS=>
MDA-MB-231 MWDLbY5ie2ViQYPzZZk> NFS3R4kyKM7:TR?= MmPYNlQhcA>? MlHCSG1UVw>? M2T3RoRw\XNibn;0JIlvcGmkaYSgTGRCSzZiYYPz[ZN{\WRiYYOgZYNmfHmuYYTpc44hdGW4ZXzzJI9nKHS3YoXsbY4> M2ryN|I{PDl|NES5
K562 NHyzemJMcW6jc3WgRZN{[Xl? NFfCUXVld2W|IH7veEBqdmirYnn0JGhFSUN? NWXsbppoOjN3OUGxNVE>
Jurkat MmftR5l1d3SxeHnjJGF{e2G7 M1jmSFIxKM7:TR?= MUm3NkBp Ml3ZSG1UVw>? MXruc{BkgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36= MVSyOFMxPDN2OB?=
HCT116 MYPBdI9xfG:|aYOgRZN{[Xl? M{jVO|Mh|ryP NYWxW29[OjRiaB?= NGTldJBFVVOR NV;BTm5K\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOVMheHKxdHXpckBt\X[nbB?= M3rRU|I1PzZ4NU[w
KASUMI-1 M4ewWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTl7LkG3JI5O MnHXV2FPT0WU
KARPAS-45 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfnTWM2OD1zN{OuPFkhdk1? MXrTRW5ITVJ?
BHT-101 NVzQXmpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfoXnREUUN3ME2yOFQvOThibl2= MnfSV2FPT0WU
H9 M2DId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW0ZYNSUUN3ME2yOVUvODRibl2= MV7TRW5ITVJ?
PA-1 NHnjSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC4bpBKSzVyPUK4Ok4zPiCwTR?= MYnTRW5ITVJ?
NEC8 M3S2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqyZYxHUUN3ME2yPFkvOzhibl2= MXHTRW5ITVJ?
MHH-PREB-1 NUDnSpBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ7ND61N{BvVQ>? M1vUR3NCVkeHUh?=
NB7 NYTr[IxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTN2NT63OEBvVQ>? M1\pSXNCVkeHUh?=
A3-KAW M3zGb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTRyMD61PUBvVQ>? NWLjU2hiW0GQR1XS
NB69 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInZRXVKSzVyPUSxNU44OSCwTR?= MWfTRW5ITVJ?
EoL-1-cell MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HmW2lEPTB;NEW0NlUhdk1? MUPTRW5ITVJ?
CHP-212 NX32WXlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTR3Nz61N{BvVQ>? NV2wfIJFW0GQR1XS
C2BBe1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnFcpFKSzVyPUS3Nk4yQSCwTR?= MXPTRW5ITVJ?
697 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PYcmlEPTB;NEezMlQyKG6P MnK1V2FPT0WU
BCPAP M4jid2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV30dGd2UUN3ME21NFEvPDJibl2= NFvHPHBUSU6JRWK=
L-363 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnqcIFKSzVyPUWwN{4yKG6P NXzRbpBHW0GQR1XS
ES8 M2ewTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTV{Mz61N{BvVQ>? M2f0c3NCVkeHUh?=
BE-13 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXSTWM2OD13Mk[uPVYhdk1? MmLpV2FPT0WU
CTB-1 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLzeIFKSzVyPUWzO{46OiCwTR?= MmrFV2FPT0WU
HD-MY-Z MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTV|OD6xN{BvVQ>? MnLUV2FPT0WU
NKM-1 NXKyOodTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHoW4hKSzVyPUW0OE4zPyCwTR?= M1jrWXNCVkeHUh?=
NCI-H720 M1PQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zGOmlEPTB;NU[wMlE5KG6P M1rsW3NCVkeHUh?=
KY821 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTV4Mz6yOUBvVQ>? NGradpFUSU6JRWK=
OVCAR-5 M3XOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\QdmhKSzVyPUW3Ok4yOSCwTR?= MlPUV2FPT0WU
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OS-RC-2 NUG0VZVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrWTWM2OD1zLki3NVUyKM7:TR?= M3TjUnNCVkeHUh?=
COLO-320-HSR MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwOEixPVch|ryP MmO3V2FPT0WU
HN NEeyO5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W3VWlEPTB;MT64PFczPSEQvF2= MXPTRW5ITVJ?
HT M{\MTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[0fGlEPTB;MT64PFk1PyEQvF2= MXjTRW5ITVJ?
LoVo MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HwXmlEPTB;MT64PVgyKM7:TR?= NELnSHZUSU6JRWK=
CGTH-W-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDrTWM2OD1zLki5PVQ3KM7:TR?= NEjDW|BUSU6JRWK=
NB6 NGD5[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zhTmlEPTB;MT65NVI6QCEQvF2= MU\TRW5ITVJ?
EW-22 NFzhZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLFTWM2OD1zLkmyPFg4KM7:TR?= MUXTRW5ITVJ?
ES6 NGXrOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwOUO2N|Eh|ryP MnjRV2FPT0WU
SCC-15 MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\GZWlEPTB;MT65N|gyQSEQvF2= M1zuenNCVkeHUh?=
HL-60 NFvmXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFwOUO5NFIh|ryP NF;vfFZUSU6JRWK=
human HOP-92 NGfabpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXv4[nl3UUN3ME2xMlk1ODZ3IN88US=> MkPUV2FPT0WU
SW626 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjhTWM2OD1zLkm0PFk6KM7:TR?= NFPOeJVUSU6JRWK=
HEC-1 NVfXcZpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwOUWzOkDPxE1? MlLFV2FPT0WU
LB2241-RCC NVnlS29CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mne4TWM2OD1zLkm4NlMyKM7:TR?= NVe3XmptW0GQR1XS
Ramos-2G6-4C10 NYHpUlZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHJWHpKSzVyPUGuPVk1QTNizszN NV24OJRjW0GQR1XS
A101D NUT5WFBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT0TWM2OD1{LkKwN|A{KM7:TR?= M1f5S3NCVkeHUh?=
NCI-H446 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n0fWlEPTB;Mj6wOFU6QSEQvF2= Ml:2V2FPT0WU
SBC-5 M3TsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjlTWM2OD1{LkC2NVQ4KM7:TR?= NF\ITY1USU6JRWK=
HOS NUKxU4tDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED5OVlKSzVyPUKuNFc3PTNizszN NEG3OpNUSU6JRWK=
K5 NE\xRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnJTWM2OD1{LkC3PFEyKM7:TR?= M1KxOXNCVkeHUh?=
HLE NHjrZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwMEi1Nlkh|ryP NIDvO45USU6JRWK=
HSC-2 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzDTGp3UUN3ME2yMlEzQDl6IN88US=> M3S5bXNCVkeHUh?=
LCLC-97TM1 M4CzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrS[GhqUUN3ME2yMlE1PTh|IN88US=> MYHTRW5ITVJ?
DMS-273 MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTkVJFiUUN3ME2yMlE1QDN5IN88US=> MoPwV2FPT0WU
TE-8 M13US2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XOOmlEPTB;Mj6xOVc3PSEQvF2= NUfoZnppW0GQR1XS
DSH1 NXi0S2I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjGZmg1UUN3ME2yMlE3Ozl6IN88US=> MX3TRW5ITVJ?
CAL-51 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJwMU[2PVkh|ryP M{DGeHNCVkeHUh?=
IST-SL1 NYOyOJRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\OTWM2OD1{LkG2PFQ1KM7:TR?= MkH6V2FPT0WU
GCT NFvSemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnueHhyUUN3ME2yMlE4PzdizszN M4[wW3NCVkeHUh?=
SW948 M{e0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HnfGlEPTB;Mj6xPFQ2PiEQvF2= NXm2e5VGW0GQR1XS
NOMO-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H1TmlEPTB;Mj6xPVMyPyEQvF2= M2PWVXNCVkeHUh?=
C8166 NYf3foVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHhbZdKSzVyPUKuNlE{OzRizszN Mk\zV2FPT0WU
OC-314 NXjiOm9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVuxfGdkUUN3ME2yMlI{OjV7IN88US=> M1izcXNCVkeHUh?=
CAL-39 M{O0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LOXmlEPTB;Mj6yN|YzPiEQvF2= MWjTRW5ITVJ?
MDA-MB-453 NXjZNoljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljsTWM2OD1{LkK0Nlc2KM7:TR?= NVPuepZ{W0GQR1XS
A673 NIO1RnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJwMkW4OlIh|ryP MnzsV2FPT0WU
HTC-C3 NHzyd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7vTWM2OD1{LkK2PFUh|ryP M{D3RnNCVkeHUh?=
NCI-H1666 M2TBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn2zTWM2OD1{LkK4NVEyKM7:TR?= MW\TRW5ITVJ?
PSN1 M1\5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7xPItKSzVyPUKuNlg6OTNizszN M3;OU3NCVkeHUh?=
GI-1 M4DIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\5WGlEPTB;Mj6zNFU1OyEQvF2= NUTHfVduW0GQR1XS
HuH-7 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\yTWM2OD1{LkOwOlM4KM7:TR?= NVvqfppWW0GQR1XS
JAR M4fofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PWT2lEPTB;Mj6zNVk5PyEQvF2= MlvLV2FPT0WU
5637 NIjXW4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmewTWM2OD1{LkOyNVI6KM7:TR?= NWrad|lsW0GQR1XS
GB-1 M2nuWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLxTWM2OD1{LkOyN|M2KM7:TR?= MXvTRW5ITVJ?
KP-N-YS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjMPWkyUUN3ME2yMlMzPjF3IN88US=> M4rFWXNCVkeHUh?=
OAW-42 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHNTWM2OD1{LkOzOFE3KM7:TR?= NYDKR29mW0GQR1XS
8-MG-BA MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfTfHVKSzVyPUKuN|M6ODZizszN NIi1ZVFUSU6JRWK=
RH-18 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDOZo1KSzVyPUKuN|UxOjJizszN M1K5dHNCVkeHUh?=
NCI-H1155 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH24TpVKSzVyPUKuN|Y4OjVizszN NX;4R49oW0GQR1XS
NB17 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;qOVBKSzVyPUKuN|gzPDNizszN MX7TRW5ITVJ?
NCI-H1437 MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP6TWM2OD1{LkSxPFc{KM7:TR?= NWDOWJV2W0GQR1XS
SN12C NV7neYNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJwNEOyNVQh|ryP NX3YU5F7W0GQR1XS
HSC-3 M1XpT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3YTWM2OD1{LkS0OVA6KM7:TR?= MnvCV2FPT0WU
GAMG MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS2TWM2OD1{LkS0OVYyKM7:TR?= MYHTRW5ITVJ?
HT-1080 NWXCSlMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz1XI9KSzVyPUKuOFQ5PjRizszN M1PFPXNCVkeHUh?=
A549 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3SzTGlEPTB;Mj60OFg6OyEQvF2= M3vtNXNCVkeHUh?=
KNS-62 MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJwNEWwOlEh|ryP Mm\oV2FPT0WU
YKG-1 M{S1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPyTWM2OD1{LkS1OFM4KM7:TR?= MWnTRW5ITVJ?
LU-134-A MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfGdmlKSzVyPUKuOFcxODhizszN NGC1S5NUSU6JRWK=
FADU MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJwNEexOlIh|ryP NV3Ob4pnW0GQR1XS
TGBC11TKB M36wPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGizcY1KSzVyPUKuOFcyPzdizszN M1ryZnNCVkeHUh?=
HT-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFryOpdKSzVyPUKuOFk2OzVizszN MmriV2FPT0WU
NCI-H2170 NYPIZ2R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnkbYhEUUN3ME2yMlUxPTR7IN88US=> Mnj4V2FPT0WU
Mo-T M1j2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLsTWM2OD1{LkWwPVI4KM7:TR?= NUO3R3RsW0GQR1XS
CCRF-CEM MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P2[2lEPTB;Mj61N|A1OyEQvF2= MVfTRW5ITVJ?
KU-19-19 NVrreGxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmntTWM2OD1{LkWzOVE{KM7:TR?= NEP4e5ZUSU6JRWK=
NCI-H1048 NGfRVGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PuN2lEPTB;Mj61OVAzPSEQvF2= M{PxenNCVkeHUh?=
KOSC-2 NVO3RpI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPjdZBKSzVyPUKuOVYxPzZizszN MXrTRW5ITVJ?
A431 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf6VlZMUUN3ME2yMlU3OzN3IN88US=> M2L0SnNCVkeHUh?=
COR-L23 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6zTWM2OD1{LkW4OVY3KM7:TR?= NGHK[2JUSU6JRWK=
MKN28 NVH5VIV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwNUmwN|ch|ryP MoT0V2FPT0WU
22RV1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrXNI1KSzVyPUKuOVkzPzRizszN MlPrV2FPT0WU
ABC-1 NF:2UWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwNkC0OkDPxE1? NFP2VWdUSU6JRWK=
NCI-H2126 MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHUWoVKSzVyPUKuOlA6QDRizszN NI\s[XBUSU6JRWK=
DoTc2-4510 NIT2c3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G4UWlEPTB;Mj62NlE5PSEQvF2= NImzUI5USU6JRWK=
SCC-4 NF\3b21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHDUplKSzVyPUKuOlMxOTJizszN M1i2VXNCVkeHUh?=
NCI-H661 M3nhNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwNkSwPFUh|ryP MXjTRW5ITVJ?
RPMI-2650 NHqxZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz5O4lKSzVyPUKuOlQyPDNizszN MnXaV2FPT0WU
NCI-H510A MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTqd3YzUUN3ME2yMlY1PDJ4IN88US=> MXzTRW5ITVJ?
BPH-1 MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;TTWM2OD1{Lk[1PFUh|ryP NH7nWY1USU6JRWK=
M14 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[1WGlEPTB;Mj62Olk6OyEQvF2= NVTsdY9iW0GQR1XS
G-402 NUPuUHZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTiWmNVUUN3ME2yMlcxPDVzIN88US=> MmHXV2FPT0WU
AsPC-1 NFn2[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\VTXllUUN3ME2yMlcyOTdizszN M1;3W3NCVkeHUh?=
NB12 M17ISGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSwXmJKSzVyPUKuO|E4OSEQvF2= MlLOV2FPT0WU
SK-HEP-1 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;PSmlEPTB;Mj63OFM6OSEQvF2= M2KwSnNCVkeHUh?=
U-266 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3QRpdwUUN3ME2yMlc4OTJzIN88US=> M17Eb3NCVkeHUh?=
AM-38 MkO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXIboVIUUN3ME2yMlc4OzV3IN88US=> NFPqVFRUSU6JRWK=
PC-14 NXz4N4hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJwOEC1NUDPxE1? MYfTRW5ITVJ?
EGI-1 M{PuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LqO2lEPTB;Mj64NVc1OyEQvF2= M2ixdXNCVkeHUh?=
LS-411N NIO2WmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJwOEKzN{DPxE1? NYXJPIo5W0GQR1XS
BFTC-905 NX\sOWJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXjVHlKSzVyPUKuPFU2OjNizszN NWG5dlVCW0GQR1XS
CaR-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJwOE[g{txO NY\p[YxpW0GQR1XS
NCI-H292 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHTPGdiUUN3ME2yMlg3PTl4IN88US=> MVzTRW5ITVJ?
8305C MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XsdmlEPTB;Mj64OlY1PSEQvF2= M2rtW3NCVkeHUh?=
SNU-449 NGr2NYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF63fmRKSzVyPUKuPFkyQDJizszN NUGzcmpNW0GQR1XS
LCLC-103H NFTp[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzTdolKSzVyPUKuPVA1OzhizszN M2PveHNCVkeHUh?=
SW1573 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJwOU[wPFIh|ryP NHfQXpNUSU6JRWK=
MLMA NF35c3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LIPGlEPTB;Mj65OlcyPyEQvF2= NEHaWWVUSU6JRWK=
NCI-H1355 NGm5eHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXKzUYxPUUN3ME2zMlAxPzl4IN88US=> MX\TRW5ITVJ?
RMG-I M4i5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfIbpV6UUN3ME2zMlAzPTl{IN88US=> M2LO[nNCVkeHUh?=
BB65-RCC NI\LTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmKwTWM2OD1|LkCzN|E1KM7:TR?= NIqxUVZUSU6JRWK=
PC-3 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3qZ|JKSzVyPUOuNFM5PzRizszN MofVV2FPT0WU
SF268 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC1dpVvUUN3ME2zMlA1PTJ|IN88US=> MXLTRW5ITVJ?
NCI-H810 NH;EbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TwN2lEPTB;Mz6wOFgzOyEQvF2= NVjwPVBxW0GQR1XS
MEG-01 M2Gw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTNwME[xOlQh|ryP MX;TRW5ITVJ?
SW13 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PnRWlEPTB;Mz6wO|g1PyEQvF2= NIT6WllUSU6JRWK=
RH-1 NF;nRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\aTWM2OD1|LkGwNlc5KM7:TR?= MWLTRW5ITVJ?
GT3TKB MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G0Z2lEPTB;Mz6xNVI5OyEQvF2= MnfMV2FPT0WU
TK10 Ml;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr4eW9WUUN3ME2zMlE{PzJ2IN88US=> MXXTRW5ITVJ?
T-24 M{jzcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL4XI9KSzVyPUOuNVUxPyEQvF2= NFftO3FUSU6JRWK=
A498 M4rsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW1TVVSUUN3ME2zMlIxQDdzIN88US=> NXjURZlFW0GQR1XS
GR-ST NX3NOmhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTNwMkKxN|kh|ryP NYLp[nBEW0GQR1XS
LB2518-MEL Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XyUWlEPTB;Mz6yNlM6QCEQvF2= NIT6XY1USU6JRWK=
T47D NV[3N5pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLWTWM2OD1|LkKzOlI4KM7:TR?= MXTTRW5ITVJ?
NCI-H1651 NHvzOnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH3TWM2OD1|LkK0OlQ1KM7:TR?= NGDGOldUSU6JRWK=
EC-GI-10 NWXGO4pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:4TWM2OD1|LkK2NVU{KM7:TR?= M2KwbHNCVkeHUh?=
HT-29 M3PQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHPVId3UUN3ME2zMlI3PjF2IN88US=> MlfiV2FPT0WU
GI-ME-N MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfnZXhIUUN3ME2zMlI6PTFzIN88US=> MUPTRW5ITVJ?
SW756 NXLUUndbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTNwMkm2Nlkh|ryP MXTTRW5ITVJ?
RKO NIrZPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTtdXh4UUN3ME2zMlMxPzV5IN88US=> NHztWppUSU6JRWK=
NCI-H1563 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVviTVEzUUN3ME2zMlM{ODF6IN88US=> Mon2V2FPT0WU
DJM-1 MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fVPWlEPTB;Mz6zO|Y4PCEQvF2= MVLTRW5ITVJ?
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SW1417 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\Tbo1bUUN3ME2yOU4zPDl6IN88US=> MXzTRW5ITVJ?
NCI-H82 NHnnTFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDITWM2OD1{Nj60Nlg5KM7:TR?= M{jYeXNCVkeHUh?=
COLO-678 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXzTWM2OD1{Nz60PVE6KM7:TR?= Mnr2V2FPT0WU
KURAMOCHI M3uxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jzOWlEPTB;MkiuNVI3KM7:TR?= MnvpV2FPT0WU
NCI-H1650 NIfRVplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm4OGRJUUN3ME2zNE4yQTJ2IN88US=> NH\mTZVUSU6JRWK=
HCC1954 NI\E[XNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\0TWM2OD1|MT6zOlY3KM7:TR?= MYPTRW5ITVJ?
GAK M1TKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17WNGlEPTB;M{KuNlYyPiEQvF2= NXrsV4VpW0GQR1XS
YAPC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLVR4ZGUUN3ME2zN{44PjR6IN88US=> NIWweVJUSU6JRWK=
NCI-H2228 M1u3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PPbWlEPTB;M{SuN|YxPSEQvF2= M3HDZ3NCVkeHUh?=
VMRC-RCZ M1izTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpenJKSzVyPUO2MlMxOjJizszN MXPTRW5ITVJ?
NMC-G1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X5eGlEPTB;M{euNFUzQSEQvF2= MnLyV2FPT0WU
D-336MG Ml3wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXZTWM2OD12MT64OFQzKM7:TR?= NFS4RYdUSU6JRWK=
UACC-62 NV[wT|l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj1V2FTUUN3ME20Nk42PTB3IN88US=> MkmxV2FPT0WU
C-33-A NVS4cJJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX6yfVNWUUN3ME20OU4{OjV4IN88US=> NYK4bWxSW0GQR1XS
HCC1937 M4PXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR5LkG5OVgh|ryP NGjiNG5USU6JRWK=
HDLM-2 NH\rNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDvTWM2OD12Nz6yNlg4KM7:TR?= NVLjbFkxW0GQR1XS
NCI-H727 M3;HU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\DOWdKSzVyPUS3MlI1PTFizszN NXvNfGRVW0GQR1XS
NY NUjaUJdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO5TWM2OD12OT6zPVA5KM7:TR?= MUjTRW5ITVJ?
NCI-H2291 NXPqdXV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTR7LkizNFEh|ryP NHPie4ZUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Water Insoluble
Ethanol '3 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms MK0683
Smiles ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Withdrawn Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID