Vorinostat (SAHA)

For research use only.

Catalog No.S1047 Synonyms: MK0683

364 publications

Vorinostat (SAHA) Chemical Structure

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

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10mM (1mL in DMSO) RMB 1558.77 In stock
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Selleck's Vorinostat (SAHA) has been cited by 364 publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MYPLbY5ie2ViQYPzZZk> NVTl[4d7OSCq NFvBdZVFVVOR Mny5ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP MoT3NVE6PjB2OEm=
Friend leukemic cell NVT5bIxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkG5OVAh|ryP NVHGfm5SPzJiaB?= NHztZ3FFVVOR MmKyTWM2OD1yLkm5JO69VQ>? MkG2NVIyODl7MUO=
K562 NWHp[IxyU2mwYYPlJGF{e2G7 M1q2U|YhcA>? NEPVZWJFVVOR NWT0Z|l{UW6qaXLpeIlwdiCxZjDoeY1idiCqaYP0c45mKGSnYXPleJlt[XOnIDjtbZh1fXKnIH;mJGhFSUNzIHHu[EBJTEGFMjmge4l1cCCLQ{WwJI9nKDBwMEGg{txO MoLPNVI1OTl|OEC=
HT1080 NHqzfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD3O|IhcA>? MVzEUXNQ NVHwRYpEUUN3ME2yMlQh|ryP NUTxS2RqOTJ{N{CxO|U>
H1299 Mmm2T4lv[XOnIFHzd4F6 MUKyNEBucW5? MWPEUXNQ NWLnOpF4UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> MYqxOFUzOTR{Mh?=
H1299 M{njS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzjV4dyPzJiaB?= M3jhdWROW09? MVzJR|UxRTdwMkSg{txO NXLzVYt1OTR3MkG0NlI>
HeLa MXzLbY5ie2ViQYPzZZk> M36zO|MxKG2rbh?= MWHJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> MmDiNVU3ODN7NEm=
LOX-IMVI MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LtdVQ5KGh? M1HDeGlEPTB;MT6zJO69VQ>? MVuxOVcyPTR5MB?=
NCI-H226 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\5TlQ5KGh? MmezTWM2OD1{Lk[g{txO MlLoNVU4OTV2N{C=
RXF-631L NID6b4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH4cnc1QCCq MXjJR|UxRTJizszN M{GwUlE2PzF3NEew
SNB-78 NWfQSpc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKzeI5wPDhiaB?= MYLJR|UxRTF4IN88US=> NHTXVIgyPTdzNUS3NC=>
St-4 M1H3SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPSe4Y1QCCq MUPJR|UxRTVwMjFOwG0> NYX2bGg1OTV5MUW0O|A>
ARP1 MV\GeY5kfGmxbjDBd5NigQ>? M1i3NlIh|ryP NY\2Ung5PiCq NVT1TWF1UW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NGDvWWoyPDd|NEiwOi=>
CEM NHXNclRMcW6jc3WgRZN{[Xl? MYqxJIg> MUnEUXNQ MkfkTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? MnvkNVY1OjByNkS=
HCT15 NGnoNXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjvNWo1QCCq MYfHTVUxRTBwOEKg{txO MoLuNVY4OjN{Mke=
NCI-H23 NXPRVGdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXW0PEBp MV\HTVUxRTBwOUKg{txO NWHp[Y9{OTZ5MkOyNlc>
GM15850 M3zoVmtqdmG|ZTDBd5NigQ>? NFH0S5EzNjVizszN M1:weVk3KGh? MULEUXNQ MWTJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MVqxOlkzOTN4Nx?=
GM15850 MmiyT4lv[XOnIFHzd4F6 M3v6dVIvPSEQvF2= MnfQPVYhcA>? MkLzSG1UVw>? MWfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViNTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MnuyNVY6OjF|Nke=
GM15850 MoHOT4lv[XOnIFHzd4F6 MWGyMlUh|ryP NFTiTI86PiCq M2\zW2ROW09? NYjMemNzUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MmLlNVY6OjF|Nke=
GM15850 NXHHS25JU2mwYYPlJGF{e2G7 NGPWOWEzNjVizszN NHO1clI6PiCq M3PCOGROW09? NWSwWFJLUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NWrub4ZNOTZ7MkGzOlc>
GM15850 NWD5VnRIU2mwYYPlJGF{e2G7 Mnf2Nk42KM7:TR?= MnvmPVYhcA>? NWfBPYRSTE2VTx?= NXzKZo1XUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M1zDWlE3QTJzM{[3
GM15850 M124XWtqdmG|ZTDBd5NigQ>? NIXIenkzNjVizszN MUC5OkBp NHL4VmRFVVOR NWfDe|FLUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M1LGb|E3QTJzM{[3
U937 M2e2eGZ2dmO2aX;uJGF{e2G7 MYq1JO69VQ>? NXjYN|dYOjRiaB?= NU\RUGQ1TE2VTx?= NHy1fVFE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn NVLUNZliOTdyMES3NVg>
H661 NHvUS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13uWlQ5KGh? M{[2b2lEPTB;MTFOwG0> M2HuSVE4OTV5MEC5
U937 M3jC[2Z2dmO2aX;uJGF{e2G7 M1fuXlUh|ryP NHfhcmYzPCCq MVLEUXNQ M2n4OWlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NVrTUGxzOTd2NEe3OVA>
U937 MXfGeY5kfGmxbjDBd5NigQ>? Ml3hNUDPxE1? NVi2RVFmOjRiaB?= MUjEUXNQ Mn;2SYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= NGXXZYgyPzR2N{e1NC=>
RAW264.7 MV;GeY5kfGmxbjDBd5NigQ>? NUDDSJF7OTBizszN MoX2NlRp MWH3ZZRmeg>? MWXJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP MnTNNVc1Pzd3MUi=
RAW264.7 NHjCSGVHfW6ldHnvckBCe3OjeR?= NHXjNoYyOCEQvF2= NWLtUJppOjSq MYD3ZZRmeg>? M1;hRmlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> MoXvNVc1Pzd3MUi=
SC9 MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;wdWs1QCCq M4TrV2lEPTB;MD62NFYh|ryP NUHHfGJtOTd3MEeyNVk>
ST14A MWjGeY5kfGmxbjDBd5NigQ>? NIfnelA2KG6P MoTRO|IhcA>? M2L4Z2lv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> M3XvS|E4PTZ3OUmz
ST14A NHL3XZJHfW6ldHnvckBCe3OjeR?= MmLlOUBvVQ>? MlLXO|IhcA>? NED6S|BKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= M4jVRlE4PTZ3OUmz
PANC1 M2LTdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVWxJO69VQ>? MYjJR|UxRTBwNEWg{txO Mln0NVc2QDh5NES=
PANC1 NF7YT3RHfW6ldHnvckBCe3OjeR?= MnnhNUDPxE1? NWrRT2hLOjRiaB?= MmTPTY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? MVSxO|U5QDd2NB?=
PANC1 NWmwZ3NOTnWwY4Tpc44hSXO|YYm= NIfYWHAyKM7:TR?= MlfpNlQhcA>? M2CwRmlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NHvkb2IyPzV6OEe0OC=>
PT45 NH7uVFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\ZZmlEPTB;NDFOwG0> NIm4NXIyPzV6OEe0OC=>
ACHN NFTHdGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUCyNUBp NGT0N2JIUTVyPUCuOlUh|ryP NIX6c5oyPzZ4Mk[wOi=>
PC3 M3XVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n6Z|IyKGh? NEnsSFlIUTVyPUCuO|Eh|ryP M3izUVE4PjZ{NkC2
A431 NU\xXFRsS3m2b4TvfIlkKEG|c3H5 NX[5O3FzPzJiaB?= MmHPTWM2OD12LkKg{txO NGDYW3MyPzZ7MUe2Ny=>
Cal27 NX7TfWliS3m2b4TvfIlkKEG|c3H5 Mm\KO|IhcA>? MWPJR|UxRTNwMjFOwG0> NEjZPGkyPzZ7MUe2Ny=>
CCRF-CEM M4ixd2N6fG:2b4jpZ{BCe3OjeR?= Ml\TO|IhcA>? NIfyXHdKSzVyPUCuPEDPxE1? NXvmbWdzOTd4OUG3OlM>
EOL1 MVHDfZRwfG:6aXOgRZN{[Xl? MlfmO|IhcA>? NGTnV|BKSzVyPUGg{txO NWnvdYUxOTd4OUG3OlM>
Hec-1-A NFn5OmJEgXSxdH;4bYMhSXO|YYm= M4TzUVczKGh? MkXOTWM2OD1zIN88US=> NU\JPVRuOTd4OUG3OlM>
HeLa MVPLbY5ie2ViQYPzZZk> MnHYNVAh|ryP NGezcW8{OCCvaX6= NHzST|ZFVVOR MlzETY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4xOiEQvF2= Mn3iNVc3QTF5NkO=
RKOp21 NHOzdnFEgXSxdH;4bYMhSXO|YYm= MY[3NkBp M{LPemlEPTB;MT63OkDPxE1? MknWNVc3QTF5NkO=
Saos2 M2jVe2N6fG:2b4jpZ{BCe3OjeR?= NI\rdZA4OiCq M2r5VWlEPTB;Mj6zJO69VQ>? NEf5[FUyPzZ7MUe2Ny=>
SK-OV-3 MVXDfZRwfG:6aXOgRZN{[Xl? M1XkTlczKGh? MV3JR|UxRTJwMjFOwG0> NHH3bVkyPzZ7MUe2Ny=>
U87MG Mlz0R5l1d3SxeHnjJGF{e2G7 M{HTbFczKGh? Ml[2TWM2OD1zMTFOwG0> MXexO|Y6OTd4Mx?=
NUGC3 M2r6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHjSHo2KM7:TR?= M1XxRlI1KGh? MmrWS2k2OD1{Lke5JO69VQ>? NEXTNIwyPzlyNEi0Ny=>
CCD1059SK NGO1eGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEH6W3BKSzVyPUSzMlUh|ryP NIfFUJoyQDJ2N{W1OC=>
HepG2 M1rl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDidFJKSzVyPUCuNFAxPiEQvF2= M1nh[FE5OjR5NUW0
HT1080 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;Yd5lKSzVyPUCuNFAzPCEQvF2= MUWxPFI1PzV3NB?=
SKBR3 M3zMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjk[YRUUUN3ME2wMlgh|ryP NXy1cYJHOTh{NEe1OVQ>
SNB78 NGrLT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofESWM2OD1zNjFOwG0> MkSwNVgzPDd3NUS=
SQ20B NGThNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXqzV|FSUUN3ME2zJO69VQ>? MV:xPFI1PzV3NB?=
St4 M2i2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3OwN2VEPTB;NT6yJO69VQ>? MnT4NVgzPDd3NUS=
MCF7 MV\GeY5kfGmxbjDBd5NigQ>? Mn3jNVAh|ryP NFPtSJk5KGh? M17hNmROW09? M2PRSWlv\HWldHnvckBw\iC2dXL1cIlvKGi7cHXyZYNmfHmuYYTpc44> NWjDVlhCOTh{NkmyNlY>
HEK293 NILBSpJMcW6jc3WgRZN{[Xl? NILjUIcyKGh? MYnEUXNQ NGf3fVNKdmirYnn0bY9vKG:oIFjERWMyKHerdHigTWM2OCCxZjCwMlA{KM7:TR?= NXHHR2huOTh|MEi1OlM>
HEK293 M4DrZWtqdmG|ZTDBd5NigQ>? M33VO|EhcA>? M1;uOmROW09? M{mwbmlvcGmkaYTpc44hd2ZiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNFU4KM7:TR?= MXWxPFMxQDV4Mx?=
G401 NFO1dIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXCZ|A{PzJiaB?= NHHQO4FFVVOR NFnZZ4hKSzVyPUGg{txO NHvtVWgyQDN5MEO3Ny=>
HeLa MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nEelczKGh? MmfHSG1UVw>? NGS2V4pKSzVyPUCuOFYh|ryP M4\EVFE5OzdyM{ez
Human renal epithelial cell MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPOO3E4OiCq NHjVZW1FVVOR NYTKT|ltUUN3ME2xOEDPxE1? MnqzNVg{PzB|N{O=
U937 MlzUSpVv[3Srb36gRZN{[Xl? MV:1JO69VQ>? NVezWG5tOjRiaB?= NE\RT4JKdmS3Y4Tpc44hd2ZiaHnzeI9v\SCKNDDofZBmemGlZYT5cIF1cW:w MWixPFM5OTJ|OB?=
U937 M4n3OWZ2dmO2aX;uJGF{e2G7 MlPsOUDPxE1? NH7jU3kzPCCq MW\JcoR2[3Srb36gc4Yh[WyyaHGgeJVjfWyrbjDofZBmemGlZYT5cIF1cW:w MYixPFM5OTJ|OB?=
U937 NIjkcHFHfW6ldHnvckBCe3OjeR?= NHfWTI82KM7:TR?= MYSyOEBp NHjIZWNKdmS3Y4Tpc44hd2ZicEKxJIV5eHKnc4Ppc44> Mli0NVg{QDF{M{i=
U937 M4PudWZ2dmO2aX;uJGF{e2G7 NHfDPFQ2KM7:TR?= Mnu3NlQhcA>? MYTJcoR2[3Srb36gc4Yh[XCxcITvd4l{ M4XRclE5OzhzMkO4
U937 NEO4elJHfW6ldHnvckBCe3OjeR?= NHHOXHg2KM7:TR?= MYCyOEBp NHi2c4pKdmS3Y4Tpc44hd2ZiZ4LhcpVtd2O7dHnjJIRq\m[ncnXueIlifGmxbh?= M2fKOVE5OzhzMkO4
U937 M1\pWmtqdmG|ZTDBd5NigQ>? Mo\6OUDPxE1? NHHPUmgzPCCq M3\K[2lvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{G= M{TiflE5OzhzMkO4
U937 NEm2fJFMcW6jc3WgRZN{[Xl? MVS1JO69VQ>? NWPVcJkyOjRiaB?= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN2 NYDUfHNDOTh|OEGyN|g>
HEK-TE MULGeY5kfGmxbjDBd5NigQ>? M{K0XFUh|ryP NXzUR5pGPmh? NGfGTHlFVVOR M{\MT2lv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NUG2WXJ{OTh2M{SxOFQ>
HPDE6c7 MmC5R5l1d3SxeHnjJGF{e2G7 NUe3bmZ5PTBizszN MWS3NkBp M171bmROW09? MWrJR|UxRTFwMzFOwG0> NG\ucVYyQDR7NES2Ny=>
Human microvascular epithelial cell MojOR5l1d3SxeHnjJGF{e2G7 NVzLTG83PTBizszN M{D5R|czKGh? NX3uO3JsTE2VTx?= NFrXeHNKSzVyPUGuN{DPxE1? NV\IVYdCOTh2OUS0OlM>
Hup T3 NUjsb3pzS3m2b4TvfIlkKEG|c3H5 NX;uTJMyPTBizszN NITtcVc4Omh? M333dGROW09? M3nSRWlEPTB;MD64JO69VQ>? MXyxPFQ6PDR4Mx?=
Mia Paca2 MmHNR5l1d3SxeHnjJGF{e2G7 MnzEOVAh|ryP NFnMTno4Omh? MXHEUXNQ NW\zU2tRUUN3ME2xMlEh|ryP MkTJNVg1QTR2NkO=
Panc 04.03 NFzBbGFEgXSxdH;4bYMhSXO|YYm= NXXIZ3FRPTBizszN NHvpPZQ4Omh? MmrTSG1UVw>? M4POTGlEPTB;MT6yJO69VQ>? NFvkbIwyQDR7NES2Ny=>
SU 86.86 NHe5UnlEgXSxdH;4bYMhSXO|YYm= NUDKOVNmPTBizszN M1rS[|czcA>? M{OzfWROW09? NFy2bppKSzVyPUGuN{DPxE1? MX[xPFQ6PDR4Mx?=
HEK293 M33YNGtqdmG|ZTDBd5NigQ>? NXfRUWpJOyCq NXvvO3BJUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBJTEGFNjDlfJBz\XO|aX;uJJdqfGhiSVO1NEBw\iByLkCxPUDPxE1? MmTENVg2PTh4Nkm=
HeLa MnvsT4lv[XOnIFHzd4F6 NW\KTndiOiCq NXHVdG1EUW6qaXLpeIlwdiCxZjDueYNt\WG{IFjERWMhf2m2aDDJR|UxKG:oIECuNFg{KM7:TR?= NYDQeZFCOTh3NUi2Olk>
RAW264.7 MXzGeY5kfGmxbjDBd5NigQ>? M1TjblIh|ryP NVfpR5J[Oy53IHi= NI\QTJFFVVOR NEX5eJpCdnSrbXHsZZJq[WxiYXP0bZZqfHliYXfhbY5{fCCSbHHzcY9lcXWvIH\hcINqeGG{dX2gbY5n\WO2ZXSge4l1cCCLQ{WwJI9nKDBwMUGg{txO NFu3VlQyQDZ2NEm2PS=>
NB4 NF3NfGc1QGh? M3LaSmROW09? MnLFTWM2OD1yLk[g{txO NIfDdZYyQDd{M{O0PS=>
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SKOV3 MYjDfZRwfG:6aXOgRZN{[Xl? NWKySXR5PzJiaB?= MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP MXSyNVA5ODZ{OR?=
COR-L23 NVLGeIRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH3[IUyOCEQvF2= NXrUZmR{PzJiaB?= NEPldHlFVVOR MUTHTVUxRTFwMTFOwG0> M1TlNlIyODhyNkS3
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LoVo M3SxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVixNEDPxE1? M1uxeVczKGh? M{TzPGROW09? NWXsXFc2T0l3ME2xMlch|ryP MUSyNVA5ODZ2Nx?=
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HCT116 NWjOb|JnU2mwYYPlJGF{e2G7 NX\4N2dEOzBizszN NI\lUIs{OCCq MWTEUXNQ NGPpc21KdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= Mn;2NlExQDB4NEe=
U937 NV\6VVM2U2mwYYPlJGF{e2G7 NUDHfpZiPSEQvF2= NGq3cpQzPCCq MmX5SG1UVw>? M{jrc2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 MmT1NlEzQTJ2OUK=
U937 M1XnTWtqdmG|ZTDBd5NigQ>? M3zQZlUh|ryP MX[yOEBp MWLEUXNQ MmK3TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzF6 MWSyNVI6OjR7Mh?=
U937 M{LpTGtqdmG|ZTDBd5NigQ>? MW[1JO69VQ>? MnnuNlQhcA>? MmW5SG1UVw>? NVfVR|BJUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHCjbj3hZ4V1gWyjdHXkJIhqe3SxbnWgTFQhdGW4ZXy= MUmyNVI6OjR7Mh?=
U937 MX;LbY5ie2ViQYPzZZk> NXz2[HdvPSEQvF2= M33ybFE2KG2rbh?= MlO2SG1UVw>? MWfJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiCuZY\lcC=> MYSyNVI6OjR7Mh?=
A2780 M2TqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:wSVNxQTZiaB?= MW\EUXNQ NX[1TnNuUUN3ME2xMlYzKM7:TR?= MkH2NlE3OzR2M{C=
COLO205 M{LSUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPDPIQ6PiCq M2\ObmROW09? MojTTWM2OD1{LkGyJO69VQ>? MWqyNVY{PDR|MB?=
Hep3B MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLBN49ZPDhiaB?= M4HIVmROW09? NHvpNWtIUTVyPUGuNlEh|ryP NFvPcoEzOTdzMkG0Oi=>
GM11272 NVnCOopzTnWwY4Tpc44hSXO|YYm= NG\tfGcyODBibl2= M132bFczKGh? NG[5bZZFVVOR Ml3UVoVi[3SrdnH0bY9vKG:oIF3lR5AzKG23dHHueEBmgHC{ZYPzbY9vKGG2IEGwJJRwKDFyMDDuUS=> NGjjTnQzOTh2MEexOi=>
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DU145 M1\iOGtqdmG|ZTDBd5NigQ>? Mof4OUDPxE1? MVSyOEBp MnHSSG1UVw>? NFznSWxKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKMzDofZBmemGlZYT5cIF1cW:w MVGyNlI3ODF4Nh?=
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A498 M{XHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[2MlIh|ryP MWC3NkBp NV7lTmt7TE2VTx?= NGLFTnJIUTVyPUGuOkDPxE1? NVXVXY5QOjJ2M{W2Olk>
A549/ATCC M3S3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPwOk4zKM7:TR?= MoPMO|IhcA>? MXjEUXNQ M3rLdWdKPTB;MT62JO69VQ>? MnXsNlI1OzV4Nkm=
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BT549 M4S2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3lR|N{Pi5{IN88US=> Mn7vO|IhcA>? M1\jbWROW09? NVzaSHdNT0l3ME2xMlMh|ryP MnfiNlI1OzV4Nkm=
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HOP92 NIDxcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz5Xpo3NjJizszN NETGNoI4OiCq NEPNN|BFVVOR MVrHTVUxRTRizszN MoPaNlI1OzV4Nkm=
IGROV1 M4jUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU[2MlIh|ryP NX61d3puPzJiaB?= NVPSV4g6TE2VTx?= Mn\WS2k2OD1zLkOg{txO MY[yNlQ{PTZ4OR?=
LOXIMVI NV23foNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLTWplGPi5{IN88US=> MknmO|IhcA>? NU\wPJBnTE2VTx?= M33ZSWdKPTB;MTFOwG0> M2DjV|IzPDN3Nk[5
M14 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfGOk4zKM7:TR?= Mn;0O|IhcA>? NY\4OJRFTE2VTx?= MX\HTVUxRTFwMzFOwG0> MlzRNlI1OzV4Nkm=
MALME-3M NXK2TWZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW3cXZpPi5{IN88US=> MYe3NkBp M2LoWWROW09? Mn70S2k2OD1yLkOyJO69VQ>? NIPWTlczOjR|NU[2PS=>
MCF10A NGXsV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X6N|YvOiEQvF2= NV;mbHROPDhiaB?= NESzXmhFVVOR NX30SXRKT0l3ME25MlYh|ryP MmnsNlI1OzV4Nkm=
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MDA-MB-468 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HQXVYvOiEQvF2= MlPkO|IhcA>? NVTkV|kzTE2VTx?= M2fLRmdKPTB;MD62N{DPxE1? MXGyNlQ{PTZ4OR?=
MOLT4 NH6xNHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELSZWg3NjJizszN NYPwNZZuPzJiaB?= MmHGSG1UVw>? MWfHTVUxRTBwNDFOwG0> MofYNlI1OzV4Nkm=
NCI-ADR-RES Mme1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ke2tTPi5{IN88US=> M3L2ZlczKGh? NUDnSG01TE2VTx?= MYHHTVUxRTBwMU[g{txO M3PQdVIzPDN3Nk[5
NCI-H23 NYr4SYJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXe2MlIh|ryP M{\GNVczKGh? NGfOPZBFVVOR MWjHTVUxRTFizszN NYPmXJd2OjJ2M{W2Olk>
NCI-H322M NVPXfol6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjBNnV{Pi5{IN88US=> NV7lbGJjPzJiaB?= NFzM[HVFVVOR NFLCV5NIUTVyPUCuO|kh|ryP NImxWWIzOjR|NU[2PS=>
NCI-H460 M1vTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEe2dFI3NjJizszN MYO3NkBp MUjEUXNQ MXLHTVUxRTBwN{mg{txO NGH1ZVQzOjR|NU[2PS=>
NCI-H522 NXzJUGJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnTOk4zKM7:TR?= NH\wSWc4OiCq M{PORmROW09? M4[zVmdKPTB;MD61JO69VQ>? NHnObJEzOjR|NU[2PS=>
OVCAR3 NXf3SIFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyxOk4zKM7:TR?= MYm3NkBp MoX6SG1UVw>? MUjHTVUxRTFwMzFOwG0> MlPBNlI1OzV4Nkm=
OVCAR4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHrdHM3NjJizszN M1nYeVczKGh? NWmw[3U5TE2VTx?= NX;Ee5k3T0l3ME20JO69VQ>? NXzzdGNQOjJ2M{W2Olk>
OVCAR5 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUe2MlIh|ryP NGPweGg4OiCq MlzISG1UVw>? NFjEOXRIUTVyPUCuO|kh|ryP MmXoNlI1OzV4Nkm=
OVCAR8 M1jHdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTSOk4zKM7:TR?= NWnMVZcyPzJiaB?= M2Th[WROW09? NWPLSHJ{T0l3ME2wMlUh|ryP M3nkUVIzPDN3Nk[5
RXF393 NHHFVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPic5A3NjJizszN MoSyO|IhcA>? MoXaSG1UVw>? M4\SfWdKPTB;MT6zJO69VQ>? Mmj3NlI1OzV4Nkm=
SF268 M4TydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorSOk4zKM7:TR?= M1n5elczKGh? MXvEUXNQ NVfKb|c4T0l3ME2xMlYh|ryP NIPYTZUzOjR|NU[2PS=>
SF295 M2rJWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\hblYvOiEQvF2= NV;BU|J5PzJiaB?= MVnEUXNQ M2rpTGdKPTB;MT62JO69VQ>? NFnNcZgzOjR|NU[2PS=>
SF539 M3\1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXjc3Y3NjJizszN MYW3NkBp NFTzeoZFVVOR Mn76S2k2OD1{IN88US=> M2O4NFIzPDN3Nk[5
SK-MEL-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\3N|YvOiEQvF2= NHTndZo4OiCq NEfJeHpFVVOR MlPpS2k2OD1zLkOg{txO MUKyNlQ{PTZ4OR?=
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SN12C MlG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXO2MlIh|ryP MnHGO|IhcA>? NHLafXhFVVOR NV60XJdOT0l3ME2yJO69VQ>? MWKyNlQ{PTZ4OR?=
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SNB75 M{Lw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2L0fFYvOiEQvF2= MnTVO|IhcA>? MnXFSG1UVw>? MYPHTVUxRTBwN{mg{txO M1K4dVIzPDN3Nk[5
SR NGLGZY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkKwOk4zKM7:TR?= NFfXfWI4OiCq M3jXNGROW09? M{TiNmdKPTB;MD60JO69VQ>? MV[yNlQ{PTZ4OR?=
T47D M3ywRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3OTG5UPi5{IN88US=> MoXaO|IhcA>? MXHEUXNQ MVHHTVUxRTBwNTFOwG0> NFe2NnozOjR|NU[2PS=>
TK10 NEDnU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mly3Ok4zKM7:TR?= MnfUO|IhcA>? MmjLSG1UVw>? NYjRT3d[T0l3ME2wMlY{KM7:TR?= NF;wcJczOjR|NU[2PS=>
UACC257 M4TkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVe2MlIh|ryP NVXzVo0{PzJiaB?= NX;FNFNUTE2VTx?= MULHTVUxRTBwNTFOwG0> MXiyNlQ{PTZ4OR?=
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UO31 NVL5OXAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT6[2FxPi5{IN88US=> M13keVczKGh? NVvXd3BPTE2VTx?= MnXoS2k2OD1yLkWg{txO M4G5TlIzPDN3Nk[5
Hep3B Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXKeJJMPDhiaB?= NEHYVppFVVOR NFr4VpJIUTVyPUCuOlkh|ryP NFzUd4QzOjR|OUi2Ny=>
BE(2)-C M{f1bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGyfo14PzJiaB?= NF3nXFlFVVOR MUPJR|cxRTJizszN NWnpe3c5OjJ7M{KzNVY>
Bel7402 NFT6R|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLjZ|lWPzJiaB?= MoroSG1UVw>? Mke3S2k6OD1zNzFOwG0> M33zeFI{ODZzM{e2
Bel7404 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxO|IhcA>? MoPVSG1UVw>? M37LWmdKQTB;MUig{txO NIfyWpAzOzB4MUO3Oi=>
BGC823 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzxR41VPzJiaB?= NELNN5VFVVOR NF25XVhIUTlyPUeuOUDPxE1? M4nIXVI{ODZzM{e2
MGC803 M1zZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPOOlM4OiCq MWjEUXNQ NV21fYVnT0l7ME2xNE45KM7:TR?= M2XmZlI{ODZzM{e2
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SKHEP1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnp[Gk4OiCq Mm\aSG1UVw>? NEG5[lhIUTlyPUG3JO69VQ>? NIjxV4kzOzB4MUO3Oi=>
SMMC7721 NUfldWsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{faTVczKGh? M3zWRmROW09? NVnQbW1QT0l7ME2yNEDPxE1? NWT1eXR4OjNyNkGzO|Y>
NUGC3 NH;1TFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\NNVAh|ryP NHPTbmdIUT1{Lkm0JO69VQ>? MmP4NlMyPjN|M{K=
A2780 CisR Moj5T4lv[XOnIFHzd4F6 NELxZ|YyQCCq MUfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNESg{txO NYLBPHpEOjN{NUK2NFM>
CAL27 sens M{XyRWtqdmG|ZTDBd5NigQ>? NUXnd4VZOThiaB?= MYHJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO NY\6bXl6OjN{NUK2NFM>
CAL27 CisR NYCwVYZkU2mwYYPlJGF{e2G7 M3HhO|E5KGh? NG[5WYdKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NHi4[oszOzJ3Mk[wNy=>
KYSE-510 CisR MnnLT4lv[XOnIFHzd4F6 MkTyNVghcA>? MkDxTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkW5JO69VQ>? NHOxVIIzOzJ3Mk[wNy=>
KYSE-510 sens M2HtfWtqdmG|ZTDBd5NigQ>? MVexPEBp MonHTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO MYiyN|I2OjZyMx?=
MDA-MB-231 sens MlH3T4lv[XOnIFHzd4F6 MoH2NVghcA>? MVrJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NGfDVFgzOzJ3Mk[wNy=>
MDA-MB-231 CisR MnzFT4lv[XOnIFHzd4F6 MV[xPEBp MWnJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MWmyN|I2OjZyMx?=
ES2 MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7DO3Y1QCCq M2LXdWROW09? NEnW[FBKSzVyPUGyMlch|ryP NUmzVHE2OjN2OUO0OFk>
MDA-MB-231 NXnpN2xvU2mwYYPlJGF{e2G7 MXGxNEDPxE1? MWezNEBucW5? MUXEUXNQ NF\ZcZdKdmirYnn0bY9vKG:oIFjERWMz[Q>? MXGyN|Q6OzR2OR?=
MDA-MB-231 NXT3bGxlU2mwYYPlJGF{e2G7 MkXSNUDPxE1? MWWyOEBp MkP3SG1UVw>? MkTCTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= MkPxNlM1QTN2NEm=
HS68 MX;DfZRwfG:6aXOgRZN{[Xl? NHHXUlcyOCEQvF2= NVj0R2ZGPzJiaB?= MkDjSG1UVw>? NFHWb25KSzVyPUSuOkDPxE1? NGTVdVUzOzV5MEW0Ni=>
MEF NVnQbWFRS3m2b4TvfIlkKEG|c3H5 Mln4NVAh|ryP M1O4clczKGh? NVv5W2ltTE2VTx?= NXi5PZIxUUN3ME20MlQh|ryP NVv1S|h[OjN3N{C1OFI>
BGC823 NUL5[IxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrEUXNQ M2XEeGdKPTB;Mz6wPUDPxE1? MVWyN|YxOTdyNh?=
High5 NUHkTm5LU2mwYYPlJGF{e2G7 Ml7JNlQhcA>? Mlv1TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? MkHkNlM3ODJ3MkO=
High5 M1jwNmtqdmG|ZTDBd5NigQ>? MXKyOEBp MUHJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NIXIdYczOzZyMkWyNy=>
High5 MVrLbY5ie2ViQYPzZZk> M1[1[FI1KGh? MkOxTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6xO{DPxE1? NU\zemc3OjN4MEK1NlM>
A549 M3jFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojiSG1UVw>? NIX3TpJKSzVyPUGuNFc6KM7:TR?= MmroNlM3PDR{MUC=
HCT116 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLLSG1UVw>? NWjmXWpuUUN3ME2wMlc2PyEQvF2= MWmyN|Y1PDJzMB?=
K562 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT1SG1UVw>? NUH5[ol5UUN3ME2wMlY1PSEQvF2= M{HKZlI{PjR2MkGw
GBC-SD NVzQOJh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorzOUDPxE1? MkHWO|IhcA>? MXrEUXNQ MVfJR|UxRTF2Lkig{txO M{HBT|I{PzB5Mk[w
HGC27 MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrBXGY2KM7:TR?= MX[3NkBp MkToSG1UVw>? NU\mc2oyUUN3ME21MlQh|ryP NXi0VZJSOjN5MEeyOlA>
HL60 M3zTc2tqdmG|ZTDBd5NigQ>? MoW5OUDPxE1? M3PDRVI1KGh? NH:4PGVFVVOR MnLyTY5pcWKrdHnvckBw\iCKRFHD NInw[4ozOzdyN{K2NC=>
Vero NVvBSlNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\USVczKGh? M1;wNGROW09? Mn;BTWM2OD1yLkmg{txO MorPNlM4QDZ2NUK=
NCI60 MoXhR5l1d3SxeHnjJGF{e2G7 MlrROFghcA>? M370b2ROW09? M4i4fGdKRTBwNUOg{txO M4PFNFI1ODF3M{K3
SW620 Mo\SR5l1d3SxeHnjJGF{e2G7 NHfHepI1QCCq NX7CVpMyTE2VTx?= NGnp[mxIUT1yLkW0JO69VQ>? MW[yOFAyPTN{Nx?=
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KM12 M{fi[GN6fG:2b4jpZ{BCe3OjeR?= NFrDWW81QCCq M3m5bWROW09? MnftS2k:OS56ODFOwG0> NIDlOXEzPDBzNUOyOy=>
Hs578T NH\aeGdEgXSxdH;4bYMhSXO|YYm= NF3VfWo1QCCq M3vHVmROW09? MVXHTV01Njh|IN88US=> NHS1c2kzPDBzNUOyOy=>
MDA-MB-231 M4nm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXEeYxUPDhiaB?= NYPyVplKUUN3ME2wMlE3KM7:TR?= M4K1bVI1ODl3MEG2
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MDA-MB-435 NXHSfnN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSyOFghcA>? Mn7JS2k:OC56ODFOwG0> NVrHbphMOjRzMUm1OVU>
AsPC1 NHTVPXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYKzNEDPxE1? MXK0PEBp M33XV2ROW09? MWnJR|UxRTNwNk[g{txO NV60fYRlOjRzOEWzO|g>
Jurkat E6.1 MV\LbY5ie2ViQYPzZZk> NGPneFIzKGh? Mn7wSG1UVw>? MVvJcohq[mm2aX;uJI9nKEiGQVO0JJdqfGhiSVO1NEBw\iByLkC0JO69VQ>? M2fUOFI1OjZzOE[y
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HEL M{XCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fLVlQ5KGh? NGfLVpdFVVOR MmPvTWM2OD1yLkS5JO69VQ>? NXX2NZBuOjR4OUSwOVU>
HSC3 M2PTSmN6fG:2b4jpZ{BCe3OjeR?= MYWxNkBp MlfCSG1UVw>? MV3JR|UxRTBwN{Gg{txO MojmNlQ4PjZ3NkC=
HT-29 NV7TTmZuS3m2b4TvfIlkKEG|c3H5 MXqxNkBp NH7GS4xFVVOR MYPJR|UxRTBwN{Kg{txO NXmxNoN3OjR5Nk[1OlA>
KB MX;DfZRwfG:6aXOgRZN{[Xl? M3jvfVEzKGh? NGn1UXNFVVOR MWTJR|UxRTBwN{Wg{txO NXv2ZmtJOjR5Nk[1OlA>
H460 M1HtZmN6fG:2b4jpZ{BCe3OjeR?= MlvNNVIhcA>? MXLEUXNQ M3i1[GlEPTB;MD64NkDPxE1? MnHxNlQ4PjZ3NkC=
MONE1 MX3DfZRwfG:6aXOgRZN{[Xl? NGPnZ|QyOiCq MnHDSG1UVw>? MVXJR|UxRTFwMUig{txO NGnST3UzPDd4NkW2NC=>
MKN45 MWHDfZRwfG:6aXOgRZN{[Xl? M{O1UlEzKGh? NEnTcGRFVVOR M1f0TmlEPTB;MT6yOUDPxE1? NYf3T2p[OjR5Nk[1OlA>
TSGH NELrTGxEgXSxdH;4bYMhSXO|YYm= NYLZfGM6OTJiaB?= MYPEUXNQ MWTJR|UxRTJwMEmg{txO M1fHV|I1PzZ4NU[w
HL60 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfacpdrPzJiaB?= NFf4OHdFVVOR MlLLS2k2OD1yLkmzJO69VQ>? M13xSVI1QTByNUCw
HEK293 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrlO|IhcA>? NGnrR3RFVVOR M33WbmdKPTB;MUOg{txO M2Hxb|I1QTByNUCw
Jurkat MWrDfZRwfG:6aXOgRZN{[Xl? MofXNVAxKM7:TR?= NF\SVYk4OiCq Ml3iS2k2OD1yLkmg{txO MmPxNlQ6ODB5NEO=
GM15850 Ml\YT4lv[XOnIFHzd4F6 Mke1Nk42KM7:TR?= MWi5OkBp MWHEUXNQ Mme1[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NE\YNmkyPjl{MUO2Oy=>
GM15850 M4\vNWtqdmG|ZTDBd5NigQ>? NIrmeGwzNjVizszN NX3jUFI3QTZiaB?= M4DROmROW09? M4TyWIRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MVqxOlkzOTN4Nx?=
GM15850 MVHLbY5ie2ViQYPzZZk> NF3qT2ozNjVizszN MVO5OkBp NVX3XGdiTE2VTx?= Mn\Z[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M1\BTFE3QTJzM{[3
GM15850 NI\INFlMcW6jc3WgRZN{[Xl? NEG1cZEzNjVizszN Mk\SPVYhcA>? MljZSG1UVw>? Mln0[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M1v5OlE3QTJzM{[3
GM15850 M{LxTmtqdmG|ZTDBd5NigQ>? MW[yMlUh|ryP NGnWU2I6PiCq NVfqSHpuTE2VTx?= NVfUUlho\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDhiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NESyeWYyPjl{MUO2Oy=>
GM15850 MlHBT4lv[XOnIFHzd4F6 NXX6eIp3Oi53IN88US=> Mmq0PVYhcA>? Mlz4SG1UVw>? M4HaTYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyPiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NEH4TFQyPjl{MUO2Oy=>
GM15850 MWrGeY5kfGmxbjDBd5NigQ>? Mn3yOUDPxE1? NHLlTHAyOiCq M1:4d2ROW09? NIrTe3Np[XNibn:g[YZn\WO2IH;uJGZZViCvUl7BJIV5eHKnc4Ppc44> Mkj1NVY6OjF|Nke=
U937 NGCx[nFMcW6jc3WgRZN{[Xl? Mo\0OUDPxE1? NUPHbGo3OjRiaB?= MoKzSG1UVw>? NXrsOHUxcGG|IH7vJIVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u NVLqRm9wOTd2NEe3OVA>
U937 NFjOPZZMcW6jc3WgRZN{[Xl? MknUNUDPxE1? MU[yOEBp MUHEUXNQ MVHoZZMhdm9iZX\m[YN1KG:wIHHsdIhiKHS3YoXsbY4h[WOndInsZZRqd25? MV[xO|Q1Pzd3MB?=
PANC1 NILLTXJHfW6ldHnvckBCe3OjeR?= MnjQNUDPxE1? M3u2WFI1KGh? NUjP[WNt\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> M2OyeVE4PTh6N{S0
PANC1 M4TBb2Z2dmO2aX;uJGF{e2G7 M{KyOFEh|ryP M3zXOFQ5KCCq Mmr5[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= NEHEblAyPzV6OEe0OC=>
Caco-2 Mn\tSpVv[3Srb36gRZN{[Xl? NYe1bGg4PSEQvF2= MkjONlQhcA>? MlTISG1UVw>? MX7kc4V{KG6xdDDpcoR2[2ViUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MYCyNFE1Ozh2MB?=
SCC4 MV;GeY5kfGmxbjDBd5NigQ>? MmHMNUDPxE1? M2fSNlExKG2rbh?= MXzEUXNQ MVXoZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? NH3rZmwzODR3MkKyOS=>
A549 MUTGeY5kfGmxbjDBd5NigQ>? MYK1JO69VQ>? M{\jSlMhcA>? M3n2VGROW09? NGPU[Ydld2W|IH7veEBqdmS3Y3WgZZV1d3CqYXf5JIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK NIOwclIzODh3NUKwPC=>
HCT116 Mn\yT4lv[XOnIFHzd4F6 MVOwMlMh|ryP NWO2XFMyOzBiaB?= M2X4d2ROW09? M3fxOYRw\XNibn;0JIlvcGmkaYSgTGRCSzFiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGirc4TvcoUhUDONOTDhZ4V1gWyjdHnvci=> NIjIXoYzOTB6ME[0Oy=>
HepG2 MkLYSpVv[3Srb36gRZN{[Xl? NHGycpUyOCEQvF2= MXSyOEBp NELaVGlFVVOR MnXP[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BpgXCncnHj[ZR6dGG2aX;uJI9nKHB3Mx?= NUjiclI1OjF3NEi1PFI>
GM11272 MXLGeY5kfGmxbjDBd5NigQ>? MXywMlEh|ryP Mm\1O|IhcA>? NUK3NJJITE2VTx?= MlP4[I9meyCwb4SgdoVi[3SrdnH0[UBO\UOyMjDteZRidnRiZYjwdoV{e2mxbh?= MXyyNVg1ODdzNh?=
MDA-MB-231 MYnLbY5ie2ViQYPzZZk> NYfEfYQ{OTBizszN NVfRVIdYPSCvaX6= NXe1W|VjTE2VTx?= MX;kc4V{KG6xdDDpcohq[mm2IFjERWMz[Q>? NEf2dlEzOzR7M{S0PS=>
MDA-MB-231 NXLYclVRU2mwYYPlJGF{e2G7 NXHJPZlvOSEQvF2= MXKyOEBp Mn:0SG1UVw>? NXnFTZdv\G:nczDuc5QhcW6qaXLpeEBJTEGFNjDhd5Nme3OnZDDhd{Bi[2W2eXzheIlwdiCuZY\lcJMhd2ZidIXieYxqdg>? MYCyN|Q6OzR2OR?=
K562 M4f2XGtqdmG|ZTDBd5NigQ>? NFuzVXJld2W|IH7veEBqdmirYnn0JGhFSUN? NHixS4QzOzV7MUGxNS=>
Jurkat MoniR5l1d3SxeHnjJGF{e2G7 NFPVfZMzOCEQvF2= M1vsd|czKGh? M3THfGROW09? MXfuc{BkgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36= MX:yOFMxPDN2OB?=
HCT116 MX7BdI9xfG:|aYOgRZN{[Xl? MX2zJO69VQ>? MYWyOEBp M1fjT2ROW09? MkXx[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCyNUOgdJJwfGWrbjDs[ZZmdA>? NWjHO3FSOjR5Nk[1OlA>
KASUMI-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLmTHhKSzVyPUm5MlE4KG6P MV3TRW5ITVJ?
KARPAS-45 NXPYXIxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnuxTWM2OD1zN{OuPFkhdk1? M1\lbHNCVkeHUh?=
BHT-101 NVHqSlE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX4XnRKSzVyPUK0OE4yQCCwTR?= MorvV2FPT0WU
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PA-1 M3zUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXjdHNKSzVyPUK4Ok4zPiCwTR?= MlzYV2FPT0WU
NEC8 M3uyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmewTWM2OD1{OEmuN|ghdk1? M2PROXNCVkeHUh?=
MHH-PREB-1 MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLxPJpqUUN3ME2yPVQvPTNibl2= Mn\YV2FPT0WU
NB7 NIXNZVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPrdnVCUUN3ME2zOFUvPzRibl2= MYjTRW5ITVJ?
A3-KAW NWnDUI8yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfDOVN2UUN3ME20NFAvPTlibl2= NEDOZ45USU6JRWK=
NB69 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXvVXh5UUN3ME20NVEvPzFibl2= M4rzXXNCVkeHUh?=
EoL-1-cell MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTR3NEK1JI5O NWHSRm1uW0GQR1XS
CHP-212 M4XvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfSclZKSzVyPUS1O{42OyCwTR?= NXnicm5XW0GQR1XS
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BE-13 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTV{Nj65OkBvVQ>? NH[zdnRUSU6JRWK=
CTB-1 MkTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTV|Nz65NkBvVQ>? NUTQbI5CW0GQR1XS
HD-MY-Z NXTCbHdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTCTWM2OD13M{iuNVMhdk1? NFnpRYxUSU6JRWK=
NKM-1 MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jX[2lEPTB;NUS0MlI4KG6P Moe0V2FPT0WU
NCI-H720 NVPXXXNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq3fVVKSzVyPUW2NE4yQCCwTR?= M4TNeXNCVkeHUh?=
KY821 Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjoe4o4UUN3ME21OlMvOjVibl2= MUXTRW5ITVJ?
OVCAR-5 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\PT4RKSzVyPUW3Ok4yOSCwTR?= M2\UbHNCVkeHUh?=
CTV-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTV6MT61OkBvVQ>? M2r3eXNCVkeHUh?=
P12-ICHIKAWA NFnUeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfaTWM2OD13OU[uOVEhdk1? MXPTRW5ITVJ?
DB MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTV7OD61O{BvVQ>? M33EWHNCVkeHUh?=
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RPMI-8226 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\xRYRKSzVyPU[3PE4yQCCwTR?= NHLTS5pUSU6JRWK=
NB14 NX;0ZohrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDab45KSzVyPU[5Ok46PSCwTR?= MUjTRW5ITVJ?
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D-423MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXqW|ZKUUN3ME23NFYvQDlibl2= M1i0R3NCVkeHUh?=
D-283MED Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHTTWM2OD15MUSuNVQhdk1? NUDVdIxnW0GQR1XS
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NCI-H209 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPG[3hQUUN3ME23NlkvQSCwTR?= NGTRcmNUSU6JRWK=
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HAL-01 M1vjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[0e3ZKSzVyPUm2PE4xPCCwTR?= M3LGXHNCVkeHUh?=
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MN-60 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTFwMEK2PEDPxE1? NXn1S3ZMW0GQR1XS
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HCT-116 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFwMUe3OUDPxE1? NX;pfJpTW0GQR1XS
MC-IXC MkfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\QTJd6UUN3ME2xMlE4QDhzIN88US=> Mn7sV2FPT0WU
LB1047-RCC NH3rdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXPTWM2OD1zLkG4N|EzKM7:TR?= NIfBfZVUSU6JRWK=
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SKG-IIIa NFjv[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PwUmlEPTB;MT6yN|Q3PCEQvF2= M{XDeHNCVkeHUh?=
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OVCAR-8 M2fiemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq2VmVKSzVyPUGuOVQ1PzdizszN NYrpcYR6W0GQR1XS
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COR-L88 M1v2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjPblVxUUN3ME2xMlU3PDJ2IN88US=> M2X4XnNCVkeHUh?=
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RT-112 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TETWlEPTB;MT61PVI5PCEQvF2= MmnJV2FPT0WU
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MHH-ES-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDoVJRyUUN3ME2xMlcxPDN3IN88US=> NX7v[WFOW0GQR1XS
CAL-27 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PrZWlEPTB;MT63NFYzOSEQvF2= M4LsdnNCVkeHUh?=
COLO-800 NFyxUo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\Be4ltUUN3ME2xMlcyOTd7IN88US=> MlzDV2FPT0WU
HCE-T M1npW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zsfmlEPTB;MT63NVUh|ryP NIr3cJpUSU6JRWK=
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LOXIMVI MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\ESGlEPTB;MT63NlEyKM7:TR?= MlzhV2FPT0WU
NH-12 M1f5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HiW2lEPTB;MT63NlY6OSEQvF2= MU\TRW5ITVJ?
TCCSUP MoXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnudnVTUUN3ME2xMlczQDJ7IN88US=> MUDTRW5ITVJ?
MDA-MB-361 M3LrVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnWdpBOUUN3ME2xMlc{OTV5IN88US=> NYPJZopIW0GQR1XS
EW-16 NW[4XmZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjzTWM2OD1zLke0NVA4KM7:TR?= MV7TRW5ITVJ?
SNU-423 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTFwN{W4Nlch|ryP MUjTRW5ITVJ?
Daoy MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\3OmVMUUN3ME2xMlc3OzF7IN88US=> Mn;DV2FPT0WU
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PFSK-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vXSmlEPTB;MT64NFM4KM7:TR?= Mof2V2FPT0WU
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ONS-76 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwOEK4PVch|ryP M4f1OHNCVkeHUh?=
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OS-RC-2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fEcGlEPTB;MT64O|E2OSEQvF2= NYTXT5JGW0GQR1XS
COLO-320-HSR NULHN4hmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwOEixPVch|ryP MV7TRW5ITVJ?
HN MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zsTGlEPTB;MT64PFczPSEQvF2= M2jh[XNCVkeHUh?=
HT NVfifGR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HIeWlEPTB;MT64PFk1PyEQvF2= Mo\1V2FPT0WU
LoVo NEXaR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTFwOEm4NUDPxE1? M4HIV3NCVkeHUh?=
CGTH-W-1 MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrENlR1UUN3ME2xMlg6QTR4IN88US=> M2G3cXNCVkeHUh?=
NB6 M{S3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XG[mlEPTB;MT65NVI6QCEQvF2= MkfiV2FPT0WU
EW-22 M17SZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjYTWM2OD1zLkmyPFg4KM7:TR?= MYPTRW5ITVJ?
ES6 NFjwOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fISmlEPTB;MT65N|Y{OSEQvF2= MknxV2FPT0WU
SCC-15 NEfafXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M333XWlEPTB;MT65N|gyQSEQvF2= NUXnTGFJW0GQR1XS
HL-60 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwOUO5NFIh|ryP NYHC[mJvW0GQR1XS
human HOP-92 MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPXZnRKSzVyPUGuPVQxPjVizszN Mm\sV2FPT0WU
SW626 NEe5V5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7qTWM2OD1zLkm0PFk6KM7:TR?= MlrjV2FPT0WU
HEC-1 NYr6[Gt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XFTmlEPTB;MT65OVM3KM7:TR?= M3\Z[HNCVkeHUh?=
LB2241-RCC MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnu5TWM2OD1zLkm4NlMyKM7:TR?= MXzTRW5ITVJ?
Ramos-2G6-4C10 NEftOZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrMTWM2OD1zLkm5OFk{KM7:TR?= NULKOY5uW0GQR1XS
A101D M4qxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqxflNKSzVyPUKuNlA{ODNizszN MYrTRW5ITVJ?
NCI-H446 M3\sTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwMES1PVkh|ryP NYSzRnlRW0GQR1XS
SBC-5 NFLOcmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X5bGlEPTB;Mj6wOlE1PyEQvF2= MlOxV2FPT0WU
HOS MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfMTGx1UUN3ME2yMlA4PjV|IN88US=> NYLpNXVuW0GQR1XS
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HLE MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDFZotlUUN3ME2yMlA5PTJ7IN88US=> NVjN[npsW0GQR1XS
HSC-2 Ml\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1v2XWlEPTB;Mj6xNlg6QCEQvF2= MnOxV2FPT0WU
LCLC-97TM1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwMUS1PFMh|ryP MlzwV2FPT0WU
DMS-273 NGq0UotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXiRZVnUUN3ME2yMlE1QDN5IN88US=> NXuxRZNyW0GQR1XS
TE-8 NIjFbZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDLTWM2OD1{LkG1O|Y2KM7:TR?= NVzR[JFlW0GQR1XS
DSH1 NGT2XJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;oTWM2OD1{LkG2N|k5KM7:TR?= NIe2N2hUSU6JRWK=
CAL-51 NYPZeGNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLSUmxKSzVyPUKuNVY3QTlizszN NVXnPVA1W0GQR1XS
IST-SL1 MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PGdGlEPTB;Mj6xOlg1PCEQvF2= MWHTRW5ITVJ?
GCT NWfUfG9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwMUe3O{DPxE1? MlTRV2FPT0WU
SW948 MlX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWyTWM2OD1{LkG4OFU3KM7:TR?= MY\TRW5ITVJ?
NOMO-1 MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJwMUmzNVch|ryP NG\yOIJUSU6JRWK=
C8166 M4Gycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJwMkGzN|Qh|ryP MnzCV2FPT0WU
OC-314 M3LsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknpTWM2OD1{LkKzNlU6KM7:TR?= NYS4OZZRW0GQR1XS
CAL-39 M4Ph[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzVTWM2OD1{LkKzOlI3KM7:TR?= NGHVbYJUSU6JRWK=
MDA-MB-453 NF;NbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XiU2lEPTB;Mj6yOFI4PSEQvF2= M4jNSHNCVkeHUh?=
A673 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjxTWM2OD1{LkK1PFYzKM7:TR?= MXPTRW5ITVJ?
HTC-C3 NY\OVo1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1{LkK2PFUh|ryP NWq3eIRDW0GQR1XS
NCI-H1666 NX3FRVNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjj[WFKSzVyPUKuNlgyOTFizszN NEDreVBUSU6JRWK=
PSN1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDITWM2OD1{LkK4PVE{KM7:TR?= NIriZXlUSU6JRWK=
GI-1 M3fiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJwM{C1OFMh|ryP MUTTRW5ITVJ?
HuH-7 MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvwflVGUUN3ME2yMlMxPjN5IN88US=> MXfTRW5ITVJ?
JAR M1i4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXsVJlNUUN3ME2yMlMyQTh5IN88US=> MX\TRW5ITVJ?
5637 M3vYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYiyNZl[UUN3ME2yMlMzOTJ7IN88US=> M2LzbnNCVkeHUh?=
GB-1 M2XrXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTOTWM2OD1{LkOyN|M2KM7:TR?= M1XjNHNCVkeHUh?=
KP-N-YS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP6TWM2OD1{LkOyOlE2KM7:TR?= MXHTRW5ITVJ?
OAW-42 NX[1SYZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTJwM{O0NVYh|ryP M2XjWXNCVkeHUh?=
8-MG-BA NGLsPJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTJwM{O5NFYh|ryP NV\OXXYzW0GQR1XS
RH-18 Mnu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf0SmZ2UUN3ME2yMlM2ODJ{IN88US=> NFKxSmdUSU6JRWK=
NCI-H1155 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO4Z2RrUUN3ME2yMlM3PzJ3IN88US=> NUjZOnI5W0GQR1XS
NB17 NVXXVXpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwM{iyOFMh|ryP MVTTRW5ITVJ?
NCI-H1437 NV;tWJpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7aTWM2OD1{LkSxPFc{KM7:TR?= Ml7oV2FPT0WU
SN12C MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV60b2IzUUN3ME2yMlQ{OjF2IN88US=> M2nOUHNCVkeHUh?=
HSC-3 NID3eo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2La[2lEPTB;Mj60OFUxQSEQvF2= NGfJT5NUSU6JRWK=
GAMG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X4dGlEPTB;Mj60OFU3OSEQvF2= NW\1dmJrW0GQR1XS
HT-1080 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfiTWM2OD1{LkS0PFY1KM7:TR?= M3LqUHNCVkeHUh?=
A549 MlfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwNES4PVMh|ryP NWD5UHRHW0GQR1XS
KNS-62 Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJwNEWwOlEh|ryP M3S0bnNCVkeHUh?=
YKG-1 NX7hT5RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED4[HZKSzVyPUKuOFU1OzdizszN MXzTRW5ITVJ?
LU-134-A Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PHS2lEPTB;Mj60O|AxQCEQvF2= Ml3GV2FPT0WU
FADU M1XrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nTO2lEPTB;Mj60O|E3OiEQvF2= MoH6V2FPT0WU
TGBC11TKB M4\UU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnDTWM2OD1{LkS3NVc4KM7:TR?= M{\U[3NCVkeHUh?=
HT-3 NVnCfmc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXDUldHUUN3ME2yMlQ6PTN3IN88US=> M{XFZ3NCVkeHUh?=
NCI-H2170 M3WwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fyc2lEPTB;Mj61NFU1QSEQvF2= NUHPNYx4W0GQR1XS
Mo-T NVKxXI5xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTITWM2OD1{LkWwPVI4KM7:TR?= NWnvNZhHW0GQR1XS
CCRF-CEM MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLYfJRlUUN3ME2yMlU{ODR|IN88US=> M{PFT3NCVkeHUh?=
KU-19-19 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSwTnVKSzVyPUKuOVM2OTNizszN M{fHdnNCVkeHUh?=
NCI-H1048 NHvQSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJwNUWwNlUh|ryP NFjnWYxUSU6JRWK=
KOSC-2 M1z6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWm1W2x4UUN3ME2yMlU3ODd4IN88US=> NIfqb|lUSU6JRWK=
A431 NYHHSIZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHKTWM2OD1{LkW2N|M2KM7:TR?= NUC5VWp4W0GQR1XS
COR-L23 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\uflJOUUN3ME2yMlU5PTZ4IN88US=> NYLFc5c5W0GQR1XS
MKN28 NH2zdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ficWlEPTB;Mj61PVA{PyEQvF2= NVzIUGQ1W0GQR1XS
22RV1 M1zEV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLSZZRKSzVyPUKuOVkzPzRizszN M{m5OHNCVkeHUh?=
ABC-1 MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LkRmlEPTB;Mj62NFQ3KM7:TR?= NFvKZmtUSU6JRWK=
NCI-H2126 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\sN|NKSzVyPUKuOlA6QDRizszN NITZboRUSU6JRWK=
DoTc2-4510 NXvMdWs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLheGhLUUN3ME2yMlYzOTh3IN88US=> NXLxNFRkW0GQR1XS
SCC-4 M2r1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwNkOwNVIh|ryP MYHTRW5ITVJ?
NCI-H661 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHwZVRKSzVyPUKuOlQxQDVizszN MUPTRW5ITVJ?
RPMI-2650 NIHScWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJwNkSxOFMh|ryP NVruTVBHW0GQR1XS
NCI-H510A MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXwSFVuUUN3ME2yMlY1PDJ4IN88US=> MU\TRW5ITVJ?
BPH-1 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJwNkW4OUDPxE1? MnX5V2FPT0WU
M14 M1z2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rXO2lEPTB;Mj62Olk6OyEQvF2= M4XsZnNCVkeHUh?=
G-402 NULtcFE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XV[WlEPTB;Mj63NFQ2OSEQvF2= M3PyZXNCVkeHUh?=
AsPC-1 M4rMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjwSotKSzVyPUKuO|EyPyEQvF2= NX7wd5FQW0GQR1XS
NB12 NULtbHVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyyTWM2OD1{LkexO|Eh|ryP MWPTRW5ITVJ?
SK-HEP-1 NIOz[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7TU5lKSzVyPUKuO|Q{QTFizszN MoLuV2FPT0WU
U-266 Ml7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m3SGlEPTB;Mj63O|EzOSEQvF2= NUXN[WdrW0GQR1XS
AM-38 NGnZNolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TEfWlEPTB;Mj63O|M2PSEQvF2= M4\qRnNCVkeHUh?=
PC-14 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PlZ2lEPTB;Mj64NFUyKM7:TR?= MWDTRW5ITVJ?
EGI-1 NX[2OJV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\IRoRKSzVyPUKuPFE4PDNizszN NX3NNWZxW0GQR1XS
LS-411N MkfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLrUGc4UUN3ME2yMlgzOzNizszN NH;oUVJUSU6JRWK=
BFTC-905 M3LNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnHTWM2OD1{Lki1OVI{KM7:TR?= M1j6SXNCVkeHUh?=
CaR-1 Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XvR2lEPTB;Mj64OkDPxE1? MlrMV2FPT0WU
NCI-H292 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFznPYxKSzVyPUKuPFY2QTZizszN M2DOSnNCVkeHUh?=
8305C MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PlbGlEPTB;Mj64OlY1PSEQvF2= MULTRW5ITVJ?
SNU-449 NFfYOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXu2bGV6UUN3ME2yMlg6OTh{IN88US=> M33nSHNCVkeHUh?=
LCLC-103H M4nUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\UXmlEPTB;Mj65NFQ{QCEQvF2= NGO2dHNUSU6JRWK=
SW1573 NGD3ZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDkXFBKSzVyPUKuPVYxQDJizszN M2nTfnNCVkeHUh?=
MLMA MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOwSW9KSzVyPUKuPVY4OTdizszN M3rOb3NCVkeHUh?=
NCI-H1355 M1f3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3K4VmlEPTB;Mz6wNFc6PiEQvF2= MlKzV2FPT0WU
RMG-I MoPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTNwMEK1PVIh|ryP MUHTRW5ITVJ?
BB65-RCC NVjXTZhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fY[GlEPTB;Mz6wN|MyPCEQvF2= NWTxTVdYW0GQR1XS
PC-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPmXXpKSzVyPUOuNFM5PzRizszN Ml;sV2FPT0WU
SF268 NHnnTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPENG9KSzVyPUOuNFQ2OjNizszN MmG1V2FPT0WU
NCI-H810 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTNwMES4NlMh|ryP NVrNXpE3W0GQR1XS
MEG-01 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTNwME[xOlQh|ryP NHvEO45USU6JRWK=
SW13 M1HsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vBemlEPTB;Mz6wO|g1PyEQvF2= NGjaR2xUSU6JRWK=
RH-1 M2K2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTNwMUCyO|gh|ryP NYPQNJJFW0GQR1XS
GT3TKB MkfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnafYRbUUN3ME2zMlEyOjh|IN88US=> NHLwNXRUSU6JRWK=
TK10 Ml;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknnTWM2OD1|LkGzO|I1KM7:TR?= NYq3XVU4W0GQR1XS
T-24 NH3aWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{npcGlEPTB;Mz6xOVA4KM7:TR?= NWXNdY11W0GQR1XS
A498 M2jTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3mxSGlEPTB;Mz6yNFg4OSEQvF2= MV7TRW5ITVJ?
GR-ST M1Tm[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLvTWM2OD1|LkKyNVM6KM7:TR?= M17WPHNCVkeHUh?=
LB2518-MEL M1LlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnhVndKSzVyPUOuNlI{QThizszN MlTTV2FPT0WU
T47D NEnyd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\kTWM2OD1|LkKzOlI4KM7:TR?= M17nSHNCVkeHUh?=
NCI-H1651 NWjyXJp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTNwMkS2OFQh|ryP NHrifVRUSU6JRWK=
EC-GI-10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPUUmZEUUN3ME2zMlI3OTV|IN88US=> MmnKV2FPT0WU
HT-29 MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHzTI1zUUN3ME2zMlI3PjF2IN88US=> MlTLV2FPT0WU
GI-ME-N MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLrTWM2OD1|LkK5OVEyKM7:TR?= NFjvVWRUSU6JRWK=
SW756 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLwUFZKSzVyPUOuNlk3OjlizszN MoOzV2FPT0WU
RKO NGHTWIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTNwM{C3OVch|ryP M{Cy[HNCVkeHUh?=
NCI-H1563 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zXfmlEPTB;Mz6zN|AyQCEQvF2= MXPTRW5ITVJ?
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NCI-H82 M3i3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXye2JKSzVyPUK2MlQzQDhizszN NVfyenU2W0GQR1XS
COLO-678 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7DepJKSzVyPUK3MlQ6OTlizszN NInuZoNUSU6JRWK=
KURAMOCHI NFi1fnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P0dmlEPTB;MkiuNVI3KM7:TR?= M1n0VHNCVkeHUh?=
NCI-H1650 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfveGIxUUN3ME2zNE4yQTJ2IN88US=> M3i0[nNCVkeHUh?=
HCC1954 NEPvN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTNzLkO2OlYh|ryP MVrTRW5ITVJ?
GAK M3PCPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjyTWM2OD1|Mj6yOlE3KM7:TR?= MVPTRW5ITVJ?
YAPC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTN|Lke2OFgh|ryP MWrTRW5ITVJ?
NCI-H2228 NVHpeVFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe3b4dmUUN3ME2zOE4{PjB3IN88US=> Ml\ZV2FPT0WU
VMRC-RCZ NVLxeZVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTN4LkOwNlIh|ryP Mn:2V2FPT0WU
NMC-G1 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjKTWM2OD1|Nz6wOVI6KM7:TR?= MoH2V2FPT0WU
D-336MG M4TJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEO0eWtKSzVyPUSxMlg1PDJizszN M1PRV3NCVkeHUh?=
UACC-62 NXnNZlFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\rSlJKSzVyPUSyMlU2ODVizszN NILYZmFUSU6JRWK=
C-33-A MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXNSY9KSzVyPUS1MlMzPTZizszN NV[4[GV4W0GQR1XS
HCC1937 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHsSYE5UUN3ME20O{4yQTV6IN88US=> NUDldYpnW0GQR1XS
HDLM-2 M{PtSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDxcI5KUUN3ME20O{4zOjh5IN88US=> MnrxV2FPT0WU
NCI-H727 NVy4dlNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR5LkK0OVEh|ryP MV3TRW5ITVJ?
NY MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3mTWM2OD12OT6zPVA5KM7:TR?= NXviUIlnW0GQR1XS
NCI-H2291 M3rnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnFTWM2OD12OT64N|AyKM7:TR?= M33CN3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms MK0683
Smiles C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Withdrawn Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID