Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 112 Publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MWHLbY5ie2ViQYPzZZk> MnT5NUBp M2nFWGROW09? NH;kcFRidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= NV\Pe5JOOTF7NkC0PFk>
Friend leukemic cell M{DVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzPemE2OCEQvF2= M1nTd|czKGh? MU\EUXNQ NVrpSZh{UUN3ME2wMlk6KM7:TR?= M3PDVlEzOTB7OUGz
K562 NIj5epdMcW6jc3WgRZN{[Xl? NWTaNnZLPiCq NVXVOpE{TE2VTx?= Mm\BTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN M4rlTFEzPDF7M{iw
HT1080 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjtPY04OiCq MmjHSG1UVw>? M2\nZWlEPTB;Mj60JO69VQ>? MXqxNlI4ODF5NR?=
H1299 NW[5OpNrU2mwYYPlJGF{e2G7 M176ZVIxKG2rbh?= MonjSG1UVw>? NVy3V256UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEiGQVOg[Y57gW2nIIfpeIghUUN3MDDv[kAxNjF7NDFOwG0> Mn7yNVQ2OjF2MkK=
H1299 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;0WoI4OiCq NYHKXYY5TE2VTx?= Mk\HTWM2OD15LkK0JO69VQ>? NHfOWYQyPDV{MUSyNi=>
HeLa MXXLbY5ie2ViQYPzZZk> NWHnUY1LOzBibXnu MkTQTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NHeyPVAyPTZyM{m0PS=>
LOX-IMVI Mn7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTKN4o{PDhiaB?= NGC3b|JKSzVyPUGuN{DPxE1? M2LiWlE2PzF3NEew
NCI-H226 M37ubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTiXVI1QCCq NHG2dVBKSzVyPUKuOkDPxE1? MUmxOVcyPTR5MB?=
RXF-631L NVzrVpdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP3OFghcA>? NHv3ZohKSzVyPUKg{txO NYHXclQ{OTV5MUW0O|A>
SNB-78 M2W1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;N[lQ5KGh? MnvoTWM2OD1zNjFOwG0> MUGxOVcyPTR5MB?=
St-4 NHfaOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X1RVQ5KGh? MXTJR|UxRTVwMjFOwG0> M1jiUVE2PzF3NEew
ARP1 NHjCU4VHfW6ldHnvckBCe3OjeR?= NGr1[YMzKM7:TR?= M4n1R|YhcA>? NWTGPWc6UW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NID4bWMyPDd|NEiwOi=>
CEM MWDLbY5ie2ViQYPzZZk> NVzLVZJJOSCq M3jLV2ROW09? NIfiXoJKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuN|Mh|ryP MWWxOlQzODB4NB?=
HCT15 MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWC0PEBp NEW2dFJIUTVyPUCuPFIh|ryP MmftNVY4OjN{Mke=
NCI-H23 Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4noWlQ5KGh? MVPHTVUxRTBwOUKg{txO MlnuNVY4OjN{Mke=
GM15850 NGnGfmhMcW6jc3WgRZN{[Xl? NV7nRoFIOi53IN88US=> Mn7jPVYhcA>? MVnEUXNQ NV7peXg5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NFPFZZcyPjl{MUO2Oy=>
GM15850 NIC5PVBMcW6jc3WgRZN{[Xl? NWfZbI5jOi53IN88US=> NX7GeGFuQTZiaB?= NFnKTGFFVVOR NIrJPWJKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= Ml7XNVY6OjF|Nke=
GM15850 MXzLbY5ie2ViQYPzZZk> NVjSXHNIOi53IN88US=> M{Wx[Fk3KGh? M3XvT2ROW09? NFvUPVBKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NH\QNnIyPjl{MUO2Oy=>
GM15850 M33F[mtqdmG|ZTDBd5NigQ>? NEfzc2QzNjVizszN M2\DNFk3KGh? M3z1VWROW09? M1zWNmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTC5JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MVOxOlkzOTN4Nx?=
GM15850 MVnLbY5ie2ViQYPzZZk> NGXKcIkzNjVizszN NGTl[ZU6PiCq NX75TVlETE2VTx?= MYHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MU[xOlkzOTN4Nx?=
GM15850 NHfGdJJMcW6jc3WgRZN{[Xl? NUDQOJRCOi53IN88US=> M{nrd|k3KGh? MYfEUXNQ MlHkTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEG2JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M3iwXVE3QTJzM{[3
U937 NVXXUYdwTnWwY4Tpc44hSXO|YYm= NGTn[FE2KM7:TR?= MVGyOEBp MULEUXNQ MlLWR4VtdCCleXPs[UBienKnc4SgZpkh[WOldX31cIF1cW:wIHH0JHMwTzJxTTDwbIF{\Q>? M1u3XVE4ODB2N{G4
H661 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUK0PEBp MXPJR|UxRTFizszN MVqxO|E2PzByOR?=
U937 NFSyc3pHfW6ldHnvckBCe3OjeR?= MlPVOUDPxE1? NHm0fIszPCCq NEj6fJRFVVOR MV3JcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w NIPRWZcyPzR2N{e1NC=>
U937 NVn3[pRGTnWwY4Tpc44hSXO|YYm= MVqxJO69VQ>? M1XzSVI1KGh? NWDxNFlpTE2VTx?= NEHoT3dG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=> MX:xO|Q1Pzd3MB?=
RAW264.7 MUjGeY5kfGmxbjDBd5NigQ>? M{H2XlExKM7:TR?= NIrScHQzPGh? NYrpUJFDf2G2ZYK= NFTMPWxKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKFSQRnHsdIhiKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFAvPzZizszN NGCyO2IyPzR5N{WxPC=>
RAW264.7 M4jLWGZ2dmO2aX;uJGF{e2G7 M4XQXVExKM7:TR?= NWDYXVN4OjSq NEjvcXR4[XSnch?= NUPRZVJ3UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? M{Gy[VE4PDd5NUG4
SC9 NUfMVodOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUSzUHNRPDhiaB?= NGLnTY5KSzVyPUCuOlA3KM7:TR?= MUmxO|UxPzJzOR?=
ST14A M1XF[2Z2dmO2aX;uJGF{e2G7 NESySpU2KG6P M3H1TVczKGh? MnftTY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW|c3nvci=> NYL2Zm1iOTd3NkW5PVM>
ST14A NVHBXoF5TnWwY4Tpc44hSXO|YYm= NHjqe5c2KG6P NGfOVIY4OiCq MWXJcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? MXSxO|U3PTl7Mx?=
PANC1 MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfmNUDPxE1? NYTldWVDUUN3ME2wMlQ2KM7:TR?= M{LLcFE4PTh6N{S0
PANC1 NWjkXHdwTnWwY4Tpc44hSXO|YYm= NULWNYQ{OSEQvF2= Mn;rNlQhcA>? MlvHTY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? NYjG[FBFOTd3OEi3OFQ>
PANC1 Ml\ISpVv[3Srb36gRZN{[Xl? MmfTNUDPxE1? NYDIc5BwOjRiaB?= MYjJcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= M3nUWFE4PTh6N{S0
PT45 NW[3T3hoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;nUGlEPTB;NDFOwG0> NULWW|ZOOTd3OEi3OFQ>
ACHN MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LKRlIyKGh? MnjES2k2OD1yLk[1JO69VQ>? MUOxO|Y3OjZyNh?=
PC3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfaVWUxOjFiaB?= M2\nS2dKPTB;MD63NUDPxE1? NInpTHQyPzZ4Mk[wOi=>
A431 M1T4N2N6fG:2b4jpZ{BCe3OjeR?= NH2wSFU4OiCq MULJR|UxRTRwMjFOwG0> M3;jNFE4PjlzN{[z
Cal27 MWDDfZRwfG:6aXOgRZN{[Xl? NYTLeId3PzJiaB?= M1izcmlEPTB;Mz6yJO69VQ>? NIPTTnEyPzZ7MUe2Ny=>
CCRF-CEM M33YUWN6fG:2b4jpZ{BCe3OjeR?= MYC3NkBp MnnyTWM2OD1yLkig{txO M2nvNFE4PjlzN{[z
EOL1 NEK2XJhEgXSxdH;4bYMhSXO|YYm= MUK3NkBp MYTJR|UxRTFizszN NVPuXWJmOTd4OUG3OlM>
Hec-1-A NVnMWnhbS3m2b4TvfIlkKEG|c3H5 M37PdVczKGh? NIfLNJVKSzVyPUGg{txO NVvRWXZFOTd4OUG3OlM>
HeLa NXrwO5l5U2mwYYPlJGF{e2G7 MX:xNEDPxE1? MY[zNEBucW5? MVzEUXNQ MYjJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlAzKM7:TR?= MVWxO|Y6OTd4Mx?=
RKOp21 MXjDfZRwfG:6aXOgRZN{[Xl? NXz6V|J3PzJiaB?= Mlf0TWM2OD1zLke2JO69VQ>? MlrNNVc3QTF5NkO=
Saos2 MXTDfZRwfG:6aXOgRZN{[Xl? MUG3NkBp NHPIXnZKSzVyPUKuN{DPxE1? MlGwNVc3QTF5NkO=
SK-OV-3 NYrtSJg5S3m2b4TvfIlkKEG|c3H5 MljYO|IhcA>? MX7JR|UxRTJwMjFOwG0> NF\1eZYyPzZ7MUe2Ny=>
U87MG NVHufoxiS3m2b4TvfIlkKEG|c3H5 MXS3NkBp M2SyemlEPTB;MUGg{txO MmXHNVc3QTF5NkO=
NUGC3 NVXhdIpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[zUVUh|ryP M2f6VlI1KGh? NIPaclJIUTVyPUKuO|kh|ryP Mnm4NVc6ODR6NEO=
CCD1059SK MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz4VJhKSzVyPUSzMlUh|ryP Mli2NVgzPDd3NUS=
HepG2 NX7XeJdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXkSG1KSzVyPUCuNFAxPiEQvF2= NIrTcnAyQDJ2N{W1OC=>
HT1080 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPTcJBKSzVyPUCuNFAzPCEQvF2= NFi4[5kyQDJ2N{W1OC=>
SKBR3 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDNOJhKSzVyPUCuPEDPxE1? MWexPFI1PzV3NB?=
SNB78 Mly5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny2SWM2OD1zNjFOwG0> NYPMTFJFOTh{NEe1OVQ>
SQ20B MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTNizszN NF7ObVEyQDJ2N{W1OC=>
St4 NFnFbZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfEfnNDTUN3ME21MlIh|ryP MoT6NVgzPDd3NUS=
MCF7 MYPGeY5kfGmxbjDBd5NigQ>? NWHwSY5XOTBizszN M2CzPVghcA>? MWfEUXNQ Ml;qTY5lfWO2aX;uJI9nKHS3YoXsbY4hcHmyZYLhZ4V1gWyjdHnvci=> NF32dZcyQDJ4OUKyOi=>
HEK293 NWf3clBXU2mwYYPlJGF{e2G7 MVWxJIg> NH;rT3pFVVOR M2frPGlvcGmkaYTpc44hd2ZiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNFMh|ryP M4nrWFE5OzB6NU[z
HEK293 NWHYbmdOU2mwYYPlJGF{e2G7 NXLtPZh2OSCq Ml;TSG1UVw>? MnO1TY5pcWKrdHnvckBw\iCKRFHDN{B4cXSqIFnDOVAhd2ZiMD6wOVch|ryP NEHYTYsyQDNyOEW2Ny=>
G401 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXrfXY4OiCq NIXZOWpFVVOR NX7CUJlDUUN3ME2xJO69VQ>? NG\2flIyQDN5MEO3Ny=>
HeLa NXfGZ2VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qxZVczKGh? NW\tZYd4TE2VTx?= M1zKPGlEPTB;MD60OkDPxE1? NHTzdWoyQDN5MEO3Ny=>
Human renal epithelial cell NVr4R2F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:3NkBp NYnvRXh4TE2VTx?= MX;JR|UxRTF2IN88US=> M1GzUFE5OzdyM{ez
U937 M2nCS2Z2dmO2aX;uJGF{e2G7 MV[1JO69VQ>? NUn2dpc5OjRiaB?= MlTmTY5lfWO2aX;uJI9nKGirc4TvcoUhUDRiaInw[ZJi[2W2eXzheIlwdg>? MWixPFM5OTJ|OB?=
U937 MYXGeY5kfGmxbjDBd5NigQ>? NXXieohbPSEQvF2= NGmwc|czPCCq NYPEc21RUW6mdXP0bY9vKG:oIHHsdIhiKHS3YoXsbY4hcHmyZYLhZ4V1gWyjdHnvci=> NFH6W3cyQDN6MUKzPC=>
U937 M1m3[WZ2dmO2aX;uJGF{e2G7 MmqwOUDPxE1? MXKyOEBp MX3JcoR2[3Srb36gc4YheDJzIHX4dJJme3Orb36= Mmr1NVg{QDF{M{i=
U937 M4\HSWZ2dmO2aX;uJGF{e2G7 M1:y[|Uh|ryP M2DGcFI1KGh? M37lWmlv\HWldHnvckBw\iCjcH;weI9{cXN? NFft[nIyQDN6MUKzPC=>
U937 NV[3WnU{TnWwY4Tpc44hSXO|YYm= NHn6fHI2KM7:TR?= NGjsVlgzPCCq NGHldlVKdmS3Y4Tpc44hd2ZiZ4LhcpVtd2O7dHnjJIRq\m[ncnXueIlifGmxbh?= MYqxPFM5OTJ|OB?=
U937 NUDOfG44U2mwYYPlJGF{e2G7 MmTnOUDPxE1? MoDCNlQhcA>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNz MYGxPFM5OTJ|OB?=
U937 MWnLbY5ie2ViQYPzZZk> M2rEd|Uh|ryP NXfDXIFyOjRiaB?= M{PDc2lvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{S= M3fCblE5OzhzMkO4
HEK-TE NXS1SpVRTnWwY4Tpc44hSXO|YYm= NWPQWpB{PSEQvF2= NHLJSpM3cA>? NXvFUFNzTE2VTx?= NGrBbJNKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u NH7BRmcyQDR|NEG0OC=>
HPDE6c7 MXvDfZRwfG:6aXOgRZN{[Xl? NWr5PYp5PTBizszN M3jteFczKGh? MlvMSG1UVw>? MknhTWM2OD1zLkOg{txO MnLBNVg1QTR2NkO=
Human microvascular epithelial cell NIPLcGxEgXSxdH;4bYMhSXO|YYm= Mn3TOVAh|ryP M2ex[VczKGh? MlTkSG1UVw>? NWDaUYs2UUN3ME2xMlMh|ryP NGjFXo4yQDR7NES2Ny=>
Hup T3 NFrBOYlEgXSxdH;4bYMhSXO|YYm= MnPGOVAh|ryP MlvWO|Jp MkXsSG1UVw>? NXe4NJg2UUN3ME2wMlgh|ryP NIfxbmIyQDR7NES2Ny=>
Mia Paca2 NF;yfnFEgXSxdH;4bYMhSXO|YYm= NUfZfJp4PTBizszN NXXL[Yh4PzKq MWfEUXNQ MXfJR|UxRTFwMTFOwG0> NEnMW2cyQDR7NES2Ny=>
Panc 04.03 NWHyclVPS3m2b4TvfIlkKEG|c3H5 Mmi4OVAh|ryP NUDjS45UPzKq NXfOWncyTE2VTx?= M{n5dWlEPTB;MT6yJO69VQ>? Mkf4NVg1QTR2NkO=
SU 86.86 NETkRVdEgXSxdH;4bYMhSXO|YYm= Mmr2OVAh|ryP Mke3O|Jp NFy2VGRFVVOR MXPJR|UxRTFwMzFOwG0> MXmxPFQ6PDR4Mx?=
HEK293 M37TOmtqdmG|ZTDBd5NigQ>? M4GwU|MhcA>? MYHJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWM3KGW6cILld5Nqd25id3n0bEBKSzVyIH;mJFAvODF7IN88US=> MnzGNVg2PTh4Nkm=
HeLa NEnCTWZMcW6jc3WgRZN{[Xl? NV\lVI9zOiCq MYTJcohq[mm2aX;uJI9nKG63Y3zlZZIhUESDQzD3bZRpKEmFNUCgc4YhOC5yOEOg{txO MUexPFU2QDZ4OR?=
RAW264.7 NHX1RWRHfW6ldHnvckBCe3OjeR?= NIL5[FIzKM7:TR?= M3XmO|MvPSCq NGH1ZopFVVOR MnnLRY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5QhWGyjc33v[Il2dSCoYXzjbZBienWvIHnu[oVkfGWmIIfpeIghUUN3MDDv[kAxNjFzIN88US=> MmqwNVg3PDR7Nkm=
NB4 M33NTlQ5cA>? NFzMN3BFVVOR M3LONWlEPTB;MD62JO69VQ>? NV;Ke4JsOTh5MkOzOFk>
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NCI-H358 NETRNGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPibIE4OiCq MV7JR|UxRTJwNTFOwG0> NH7nSWgzODF2M{e3PC=>
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A549 NWfaVWdwS3m2b4TvfIlkKEG|c3H5 MWq3NkBp NUj6bmJzS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN NYCzeVJFOjFyOEC2Nlk>
CAL27 NILjVY1EgXSxdH;4bYMhSXO|YYm= MlXlO|IhcA>? MoHQR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gR2FNOjdiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gN{4zKM7:TR?= NXXuclk2OjFyOEC2Nlk>
HeLa NFize|ZEgXSxdH;4bYMhSXO|YYm= NV3COXVlPzJiaB?= NFqyWGZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= MV2yNVA5ODZ{OR?=
Sf21 MYDLbY5ie2ViQYPzZZk> NHzYUWo{KGh? NVy2UG5xUW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> NE[0b3EzOTB6ME[yPS=>
SKBR3 NVzrfJNxS3m2b4TvfIlkKEG|c3H5 NVHLSHNbPzJiaB?= NEDheoVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszN NG\aS5kzOTB6ME[yPS=>
SKOV3 MUjDfZRwfG:6aXOgRZN{[Xl? NXHzNGRvPzJiaB?= Mo\xR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= NVfoVY1sOjFyOEC2Nlk>
COR-L23 MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlK2NVAh|ryP MYK3NkBp M1fnNGROW09? M163WWdKPTB;MT6xJO69VQ>? NYn6ZYRtOjFyOEC2OFc>
DU145 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nJSlExKM7:TR?= NFfZRoI4OiCq NF7DR4hFVVOR NVLEdZJTT0l3ME2xMlA2KM7:TR?= M1vldFIyODhyNkS3
LoVo MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGna[FkyOCEQvF2= NFrqN2U4OiCq M1TSPGROW09? M{DKdGdKPTB;MT63JO69VQ>? NH7OS5QzOTB6ME[0Oy=>
MCR5-SV2 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPPdIoyOCEQvF2= M4jaZ|czKGh? MnzPSG1UVw>? NWTCPYo1T0l3ME2yMlEh|ryP MkTGNlExQDB4NEe=
HCT116 MmPsT4lv[XOnIFHzd4F6 Ml;RN|Ah|ryP NEXMOGc{OCCq NUjQXWVmTE2VTx?= Mn[xTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= NYfNcWRyOjFyOEC2OFc>
HCT116 MWHLbY5ie2ViQYPzZZk> MUezNEDPxE1? M3m1OFMxKGh? MWXEUXNQ NIT0bYtKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= M32zNVIyODhyNkS3
U937 MlS4T4lv[XOnIFHzd4F6 NYnmTZVpPSEQvF2= NF3lWYIzPCCq M2H2[GROW09? MVfJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMQQ>? Mnv4NlEzQTJ2OUK=
U937 MmPqT4lv[XOnIFHzd4F6 M1jaTFUh|ryP M1nufFI1KGh? M3XtWGROW09? NUnkNHUxUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 M370OVIyOjl{NEmy
U937 MVvLbY5ie2ViQYPzZZk> NEHld4c2KM7:TR?= M16xT|I1KGh? MoewSG1UVw>? NGjSSHdKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= NEn3NpQzOTJ7MkS5Ni=>
U937 NHGy[lhMcW6jc3WgRZN{[Xl? NYjEdoxsPSEQvF2= M4G4VFE2KG2rbh?= MkDZSG1UVw>? NI\reppKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjDs[ZZmdA>? NHXGSmkzOTJ7MkS5Ni=>
A2780 NXPDO2dsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL6PVYhcA>? M{HiOWROW09? MXfJR|UxRTFwNkKg{txO NX2zPFg2OjF4M{S0N|A>
COLO205 NGrpbZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK5fpVYQTZiaB?= NIKwVXBFVVOR NYnDOotvUUN3ME2yMlEzKM7:TR?= NXnQRmRDOjF4M{S0N|A>
Hep3B NXjXXIJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDL[VA1QCCq M133d2ROW09? MofPS2k2OD1zLkKxJO69VQ>? MXuyNVcyOjF2Nh?=
GM11272 Ml\HSpVv[3Srb36gRZN{[Xl? MmjMNVAxKG6P NF;1d4g4OiCq NXH4NopCTE2VTx?= MWHS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N M1HyS|IyQDRyN{G2
CFBE41o Ml3mT4lv[XOnIFHzd4F6 M{DCZVUh|ryP MXnEUXNQ NWC2e3RlTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP NH3CeXYzOTl6NEm1PC=>
CFBE41o NFLCfpRHfW6ldHnvckBCe3OjeR?= NHW2Z48yKM7:TR?= MojlNlQhcA>? MULEUXNQ MlLMVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| MnPhNlE6QDR7NUi=
DU145 NFjzW3dMcW6jc3WgRZN{[Xl? MV2yMlUh|ryP NIS0XFQzPCCq NWnNN2kyTE2VTx?= M4O1dmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> M1XFOVIzOjZyMU[2
DU145 M4[4VmtqdmG|ZTDBd5NigQ>? MUK1JO69VQ>? MVSyOEBp M2PORWROW09? MnrlTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= M2Hu[|IzOjZyMU[2
DU145 M4i2TGtqdmG|ZTDBd5NigQ>? MljIOUDPxE1? MnKxNlQhcA>? NI\6coFFVVOR NYHaXJZmUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSEOgbJlx\XKjY3X0fYxifGmxbh?= NXLWfnRPOjJ{NkCxOlY>
786-0 NGD3WlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M331WlYvOiEQvF2= MVi3NkBp NUXWNWdnTE2VTx?= MUXHTVUxRTNwMjFOwG0> NWPW[phFOjJ2M{W2Olk>
A498 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvqOk4zKM7:TR?= M{\sW|czKGh? MkXFSG1UVw>? M17MdGdKPTB;MT62JO69VQ>? MlXJNlI1OzV4Nkm=
A549/ATCC M4Cwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlSyOk4zKM7:TR?= MlrwO|IhcA>? M2e1Z2ROW09? NIHPT3NIUTVyPUGuOkDPxE1? MWGyNlQ{PTZ4OR?=
ACHN MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonVOk4zKM7:TR?= Ml7vO|IhcA>? NWrMbpFMTE2VTx?= NXLpWZkzT0l3ME2xMlMh|ryP NFzUZXUzOjR|NU[2PS=>
BT549 MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDCc2o3NjJizszN NHv5fmw4OiCq MmDHSG1UVw>? MmHhS2k2OD1zLkOg{txO MnSxNlI1OzV4Nkm=
EKVX MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYOxUFhUPi5{IN88US=> MmPSO|IhcA>? M4DCb2ROW09? Mk\4S2k2OD1zLkOg{txO NFHER3QzOjR|NU[2PS=>
HCT15 NUmwNmJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HxdFYvOiEQvF2= M{HBXlczKGh? NFm3PIZFVVOR Mm[xS2k2OD1{LkWg{txO M2iwPVIzPDN3Nk[5
HOP92 NWe5dpR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MluwOk4zKM7:TR?= M{LxdlczKGh? NVLuN5M6TE2VTx?= M2n2OWdKPTB;NDFOwG0> NWr4VG1lOjJ2M{W2Olk>
IGROV1 Mn\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX5UoExPi5{IN88US=> M{\WeVczKGh? MlPhSG1UVw>? M4LiWWdKPTB;MT6zJO69VQ>? MWGyNlQ{PTZ4OR?=
LOXIMVI MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOydXc5Pi5{IN88US=> MlzVO|IhcA>? MljjSG1UVw>? NFzzZWpIUTVyPUGg{txO NH;WXHQzOjR|NU[2PS=>
M14 M{LRV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DsblYvOiEQvF2= MUS3NkBp NVS2NnBbTE2VTx?= NIHr[opIUTVyPUGuN{DPxE1? NHL2WmYzOjR|NU[2PS=>
MALME-3M MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;lOk4zKM7:TR?= NV7Pcm9nPzJiaB?= M3PWRWROW09? MlnxS2k2OD1yLkOyJO69VQ>? M1XudlIzPDN3Nk[5
MCF10A NXzJV3Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm2MlIh|ryP NGXoeIw1QCCq MVfEUXNQ MVjHTVUxRTlwNjFOwG0> M3e5W|IzPDN3Nk[5
MDA-MB-435 NVvMRmJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLlOk4zKM7:TR?= NYS4fIpWPzJiaB?= MlrBSG1UVw>? MXvHTVUxRTBwNTFOwG0> M2XyTVIzPDN3Nk[5
MDA-MB-468 NI[4fVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTkXpZsPi5{IN88US=> NUjWSXJUPzJiaB?= NVGwW3BJTE2VTx?= MVzHTVUxRTBwNkOg{txO NVH5RppGOjJ2M{W2Olk>
MOLT4 NYfybG5DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXDUoo3NjJizszN M1rofVczKGh? NGj1e5NFVVOR MoXmS2k2OD1yLkSg{txO M1z2WVIzPDN3Nk[5
NCI-ADR-RES MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CydlYvOiEQvF2= M3vFcFczKGh? NGW4R2NFVVOR NUHwZXRrT0l3ME2wMlE3KM7:TR?= MYSyNlQ{PTZ4OR?=
NCI-H23 NUDOV4JkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLF[lc3NjJizszN M1voNFczKGh? NIDOR2tFVVOR MoPrS2k2OD1zIN88US=> NFLrToczOjR|NU[2PS=>
NCI-H322M M{\NN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXS2MlIh|ryP M4\LeVczKGh? NV;x[4djTE2VTx?= MX\HTVUxRTBwN{mg{txO NFHMfmMzOjR|NU[2PS=>
NCI-H460 NVfmZ3R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXybplNPi5{IN88US=> M1TNNFczKGh? MV3EUXNQ NWL1ZpJYT0l3ME2wMlc6KM7:TR?= NWOyWGFqOjJ2M{W2Olk>
NCI-H522 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXO2MlIh|ryP NHK1Slk4OiCq MYrEUXNQ MU\HTVUxRTBwNTFOwG0> NH;FUY8zOjR|NU[2PS=>
OVCAR3 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XoRVYvOiEQvF2= MXq3NkBp M{LleWROW09? MWjHTVUxRTFwMzFOwG0> NGTxUZQzOjR|NU[2PS=>
OVCAR4 NILIVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ThNFYvOiEQvF2= NX30bFhXPzJiaB?= MVzEUXNQ NGOwU5FIUTVyPUSg{txO NHX4NYgzOjR|NU[2PS=>
OVCAR5 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PxdVYvOiEQvF2= MlPFO|IhcA>? M4nob2ROW09? MWLHTVUxRTBwN{mg{txO MmflNlI1OzV4Nkm=
OVCAR8 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnuOk4zKM7:TR?= M3Pib|czKGh? M1rHW2ROW09? MlSzS2k2OD1yLkWg{txO M{HZPVIzPDN3Nk[5
RXF393 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrxcW1SPi5{IN88US=> NFTTT4w4OiCq NYHiXVRkTE2VTx?= M1fDeGdKPTB;MT6zJO69VQ>? MnrWNlI1OzV4Nkm=
SF268 NX7jdmJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny1Ok4zKM7:TR?= MWi3NkBp MXjEUXNQ MWnHTVUxRTFwNjFOwG0> NUjQb4ZNOjJ2M{W2Olk>
SF295 NVvFcIw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnntOk4zKM7:TR?= NFHUZ244OiCq M1nyNWROW09? MYrHTVUxRTFwNjFOwG0> NGezR2YzOjR|NU[2PS=>
SF539 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX1XYw3NjJizszN MXu3NkBp MX3EUXNQ NXXveolET0l3ME2yJO69VQ>? M{DwZ|IzPDN3Nk[5
SK-MEL-2 M3PlOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnlXlR[Pi5{IN88US=> M1XYVVczKGh? MkL0SG1UVw>? NVLJcJM2T0l3ME2xMlMh|ryP MWqyNlQ{PTZ4OR?=
SK-MEL-28 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnqOk4zKM7:TR?= NGnNZYQ4OiCq MV\EUXNQ MmnNS2k2OD1zIN88US=> NYf5OoNrOjJ2M{W2Olk>
SK-MEL-5 M2OzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXy2MlIh|ryP Ml;PO|IhcA>? MkS2SG1UVw>? MVzHTVUxRTBwNkOg{txO NX:2V5dtOjJ2M{W2Olk>
SKOV3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLCN|U3NjJizszN M{DEU|czKGh? NHHDdnhFVVOR NXj0V5hWT0l3ME2xJO69VQ>? NH;CUHUzOjR|NU[2PS=>
SN12C M3vYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\acpk3NjJizszN MXS3NkBp NVXmbVBVTE2VTx?= MWjHTVUxRTJizszN MY[yNlQ{PTZ4OR?=
SNB19 Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlv4Ok4zKM7:TR?= MY[3NkBp MmHJSG1UVw>? MU\HTVUxRTBwNkOg{txO M1jLOVIzPDN3Nk[5
SNB75 M2CyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPqUVQ3NjJizszN NWXkNWp1PzJiaB?= NWnJNVVvTE2VTx?= MYLHTVUxRTBwN{mg{txO MXqyNlQ{PTZ4OR?=
SR MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPHWZQ3NjJizszN NWG0RlNZPzJiaB?= NXHqRlFWTE2VTx?= NF:xWIlIUTVyPUCuOEDPxE1? M2f0TFIzPDN3Nk[5
T47D NWnobo9nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF23PZU3NjJizszN Mkm0O|IhcA>? NF3ESW5FVVOR NVnZepRQT0l3ME2wMlUh|ryP NH7yXWMzOjR|NU[2PS=>
TK10 NUXEPYdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy2O4ZIPi5{IN88US=> NGW0VXA4OiCq NF[xV3BFVVOR MnvNS2k2OD1yLk[zJO69VQ>? MorqNlI1OzV4Nkm=
UACC257 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPsSXo3NjJizszN NXrk[|FoPzJiaB?= M3\FOmROW09? NX7DUHB5T0l3ME2wMlUh|ryP MonINlI1OzV4Nkm=
UACC62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWG2MlIh|ryP NXK1dWtZPzJiaB?= NWjsPJJPTE2VTx?= M4TGZmdKPTB;MD60JO69VQ>? MojINlI1OzV4Nkm=
UO31 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVS2MlIh|ryP MUW3NkBp M33sUGROW09? NUDDcIM3T0l3ME2wMlUh|ryP NITTVGkzOjR|NU[2PS=>
Hep3B NVizVYhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnmOFghcA>? M1:1OmROW09? NFTuWG1IUTVyPUCuOlkh|ryP Mn3oNlI1Ozl6NkO=
BE(2)-C Mmf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7KcYs4OiCq M4f6OmROW09? NGPpOpFKSzdyPUKg{txO M3nUd|IzQTN{M{G2
Bel7402 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjVO|IhcA>? NX\2UZl{TE2VTx?= MYTHTVkxRTF5IN88US=> MY[yN|A3OTN5Nh?=
Bel7404 MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTIO|IhcA>? NGLMfFBFVVOR MmTvS2k6OD1zODFOwG0> M1TMW|I{ODZzM{e2
BGC823 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fFNlczKGh? NVHU[3l{TE2VTx?= NFXHNZBIUTlyPUeuOUDPxE1? NXHQcVJkOjNyNkGzO|Y>
MGC803 MnjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT5O|IhcA>? NEDR[5ZFVVOR NFywcJVIUTlyPUGwMlgh|ryP MWqyN|A3OTN5Nh?=
SGC7901 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCye5RHPzJiaB?= M3fMPWROW09? NFntd3hIUTlyPUmuOEDPxE1? NH20N5EzOzB4MUO3Oi=>
SKHEP1 NInibJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7HRmp1PzJiaB?= MUXEUXNQ M{XodmdKQTB;MUeg{txO MUWyN|A3OTN5Nh?=
SMMC7721 NF\oWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTpWZc4OiCq NVnZVplkTE2VTx?= MXnHTVkxRTJyIN88US=> NIryd4ozOzB4MUO3Oi=>
NUGC3 M2TrfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWOxNEDPxE1? NEjofmtIUT1{Lkm0JO69VQ>? MYmyN|E3OzN|Mh?=
A2780 CisR MXnLbY5ie2ViQYPzZZk> M4rYTlE5KGh? NV;2dGx3UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M1;oUVI{OjV{NkCz
CAL27 sens NYe1NJgzU2mwYYPlJGF{e2G7 NFLs[3MyQCCq MoLNTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? NU\PdmhmOjN{NUK2NFM>
CAL27 CisR NGfr[pJMcW6jc3WgRZN{[Xl? M4P3TVE5KGh? NI\Qc5lKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MX2yN|I2OjZyMx?=
KYSE-510 CisR M2rpcWtqdmG|ZTDBd5NigQ>? M2PrR|E5KGh? MVrJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO M1zlOlI{OjV{NkCz
KYSE-510 sens MUHLbY5ie2ViQYPzZZk> NITHeIIyQCCq MofBTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkeg{txO M3q4N|I{OjV{NkCz
MDA-MB-231 sens MnTPT4lv[XOnIFHzd4F6 MV[xPEBp MX;Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NU\ZN4VMOjN{NUK2NFM>
MDA-MB-231 CisR M2rkbmtqdmG|ZTDBd5NigQ>? MX6xPEBp NVvKN4Q3UW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= NVnzXFlFOjN{NUK2NFM>
ES2 M1uyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPxT2s1QCCq MVXEUXNQ NUGwc5pEUUN3ME2xNk44KM7:TR?= M3zZclI{PDl|NES5
MDA-MB-231 MXTLbY5ie2ViQYPzZZk> NVjGVnpqOTBizszN MlK2N|AhdWmw MV;EUXNQ MVfJcohq[mm2aX;uJI9nKEiGQVOyZS=> NGGzWnYzOzR7M{S0PS=>
MDA-MB-231 NHTTXXdMcW6jc3WgRZN{[Xl? NIDwNoQyKM7:TR?= Mlz0NlQhcA>? NETMVphFVVOR M1;IcGlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= NYGzb29[OjN2OUO0OFk>
HS68 M1TPWmN6fG:2b4jpZ{BCe3OjeR?= M{f5OlExKM7:TR?= MVS3NkBp MVXEUXNQ NEj3dlJKSzVyPUSuOkDPxE1? NUn4PIpWOjN3N{C1OFI>
MEF MlLSR5l1d3SxeHnjJGF{e2G7 MUGxNEDPxE1? MVu3NkBp NGPuO4FFVVOR NV3kbIJqUUN3ME20MlQh|ryP MlnSNlM2PzB3NEK=
BGC823 NVnFV3dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrn[GZ3TE2VTx?= MnfQS2k2OD1|LkC5JO69VQ>? NWTHSVR[OjN4MEG3NFY>
High5 NXqwVGt2U2mwYYPlJGF{e2G7 NH;Ce2YzPCCq M1TkPGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP NV\LfWlmOjN4MEK1NlM>
High5 MXzLbY5ie2ViQYPzZZk> NXL5RphpOjRiaB?= Mnu1TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? M2rPc|I{PjB{NUKz
High5 NYrwWIxGU2mwYYPlJGF{e2G7 NWjDdnFkOjRiaB?= NFzvWnBKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NUfoRlBPOjN4MEK1NlM>
A549 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvJXpMyTE2VTx?= MkKwTWM2OD1zLkC3PUDPxE1? MV[yN|Y1PDJzMB?=
HCT116 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm1ZldTTE2VTx?= NGTWWXlKSzVyPUCuO|U4KM7:TR?= MVmyN|Y1PDJzMB?=
K562 NGHLb4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrEUXNQ NYSwemNCUUN3ME2wMlY1PSEQvF2= NVTTbmttOjN4NESyNVA>
GBC-SD NVTVVWJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HkU|Uh|ryP MYC3NkBp NF3wRXpFVVOR MXzJR|UxRTF2Lkig{txO NGfsS3QzOzdyN{K2NC=>
HGC27 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli2OUDPxE1? NELRZYo4OiCq Mn\XSG1UVw>? MYfJR|UxRTVwNDFOwG0> MnPZNlM4ODd{NkC=
HL60 MlLJT4lv[XOnIFHzd4F6 M{fG[lUh|ryP MViyOEBp MWrEUXNQ NHLMWFJKdmirYnn0bY9vKG:oIFjERWM> NFixVVEzOzdyN{K2NC=>
Vero NHvJXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXTVGFjPzJiaB?= NIixbW5FVVOR MlvrTWM2OD1yLkmg{txO M13tdFI{Pzh4NEWy
NCI60 NHLsbolEgXSxdH;4bYMhSXO|YYm= MmnlOFghcA>? NGX4V5pFVVOR NVLEZW9oT0l;MD61N{DPxE1? M2jvNFI1ODF3M{K3
SW620 NUXVe4s1S3m2b4TvfIlkKEG|c3H5 NXLzflRVPDhiaB?= M{L4ZmROW09? MUfHTV0xNjV2IN88US=> MkXzNlQxOTV|Mke=
U251 M4PRU2N6fG:2b4jpZ{BCe3OjeR?= MYW0PEBp MV\EUXNQ NE\TdFZIUT1zLkWzJO69VQ>? M3\JSFI1ODF3M{K3
KM12 NGfYOW1EgXSxdH;4bYMhSXO|YYm= NYPpNXl1PDhiaB?= MnW1SG1UVw>? MoXoS2k:OS56ODFOwG0> MYiyOFAyPTN{Nx?=
Hs578T MX3DfZRwfG:6aXOgRZN{[Xl? MYK0PEBp NWPXdYJSTE2VTx?= NYfK[3RkT0l;ND64N{DPxE1? Mm\kNlQxOTV|Mke=
MDA-MB-231 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M336flQ5KGh? MUTJR|UxRTBwMU[g{txO MmnPNlQxQTVyMU[=
MCF7 NWTIN5hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPzOFghcA>? MVHHTV0xNjR3IN88US=> M2rMeFI1OTF7NUW1
MDA-MB-435 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHuPWVLPDhiaB?= NILHb2pIUT1yLki4JO69VQ>? NYjQOVVjOjRzMUm1OVU>
AsPC1 NGTrd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXezNEDPxE1? MX[0PEBp NUXXXpFJTE2VTx?= MlnsTWM2OD1|Lk[2JO69VQ>? NGT1eowzPDF6NUO3PC=>
Jurkat E6.1 NXjNeJhtU2mwYYPlJGF{e2G7 MWSyJIg> MVrEUXNQ M2PQbWlvcGmkaYTpc44hd2ZiSFTBR|Qhf2m2aDDJR|UxKG:oIECuNFQh|ryP M13sflI1OjZzOE[y
KG1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnwTHk1QCCq M130emlEPTB;MT6xOUDPxE1? MW[yOFUzPTByMx?=
HEL NIPJVnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LLZ|Q5KGh? NVTpRXVNTE2VTx?= NFLhW3VKSzVyPUCuOFkh|ryP MWeyOFY6PDB3NR?=
HSC3 MlqzR5l1d3SxeHnjJGF{e2G7 Mn70NVIhcA>? Mkn5SG1UVw>? MnO3TWM2OD1yLkexJO69VQ>? NFrhflAzPDd4NkW2NC=>
HT-29 NHvWcYJEgXSxdH;4bYMhSXO|YYm= MU[xNkBp NGnjWmpFVVOR MYnJR|UxRTBwN{Kg{txO MYOyOFc3PjV4MB?=
KB NHfye5BEgXSxdH;4bYMhSXO|YYm= MlLsNVIhcA>? NYD5dXg1TE2VTx?= MV7JR|UxRTBwN{Wg{txO MVGyOFc3PjV4MB?=
H460 NFv0[FFEgXSxdH;4bYMhSXO|YYm= M2LVWlEzKGh? MV7EUXNQ M3fzb2lEPTB;MD64NkDPxE1? M1\MS|I1PzZ4NU[w
MONE1 MYLDfZRwfG:6aXOgRZN{[Xl? M1LGc|EzKGh? M2n4cGROW09? NVOzUIE{UUN3ME2xMlE5KM7:TR?= Ml\xNlQ4PjZ3NkC=
MKN45 MX;DfZRwfG:6aXOgRZN{[Xl? M4i4VFEzKGh? MXTEUXNQ NFXCWJRKSzVyPUGuNlUh|ryP NIH0OlEzPDd4NkW2NC=>
TSGH MW\DfZRwfG:6aXOgRZN{[Xl? M1TPbFEzKGh? MnLlSG1UVw>? NXziVoNZUUN3ME2yMlA6KM7:TR?= M3LRR|I1PzZ4NU[w
HL60 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLHO|IhcA>? M335d2ROW09? MmjqS2k2OD1yLkmzJO69VQ>? NETiN44zPDlyMEWwNC=>
HEK293 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHLS5g4OiCq MWLEUXNQ NWPS[mloT0l3ME2xN{DPxE1? MoHiNlQ6ODB3MEC=
Jurkat Mmi2R5l1d3SxeHnjJGF{e2G7 NEjWXVgyODBizszN MUe3NkBp NHTNd4NIUTVyPUCuPUDPxE1? MlLENlQ6ODB5NEO=
GM15850 M2LWXWtqdmG|ZTDBd5NigQ>? NGHwOXEzNjVizszN NVvCc4NIQTZiaB?= MX7EUXNQ MkfW[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M3Lab|E3QTJzM{[3
GM15850 MYjLbY5ie2ViQYPzZZk> MUOyMlUh|ryP MoizPVYhcA>? Ml3xSG1UVw>? NF36VYZld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhPSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MUKxOlkzOTN4Nx?=
GM15850 NXK1WIJYU2mwYYPlJGF{e2G7 MUeyMlUh|ryP NIfPe5E6PiCq MoXxSG1UVw>? Mlnm[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NHLtenYyPjl{MUO2Oy=>
GM15850 NV:4WoZvU2mwYYPlJGF{e2G7 MnjzNk42KM7:TR?= M1XKbVk3KGh? NVTlOllYTE2VTx?= M17VcoRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MUexOlkzOTN4Nx?=
GM15850 MUjLbY5ie2ViQYPzZZk> NEDDclczNjVizszN MUe5OkBp M{i3[WROW09? M3zX[oRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA5KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MlHDNVY6OjF|Nke=
GM15850 NGLycmdMcW6jc3WgRZN{[Xl? MnHLNk42KM7:TR?= NFz6OXM6PiCq MmW2SG1UVw>? Mm\K[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NIi2dnkyPjl{MUO2Oy=>
GM15850 NHr4cXhHfW6ldHnvckBCe3OjeR?= M2PndVUh|ryP MkTrNVIhcA>? MWTEUXNQ NF[yT3lp[XNibn:g[YZn\WO2IH;uJGZZViCvUl7BJIV5eHKnc4Ppc44> MkX6NVY6OjF|Nke=
U937 M1jE[WtqdmG|ZTDBd5NigQ>? M4jaOVUh|ryP MlXlNlQhcA>? NHm0flhFVVOR NHXZNoZp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= NH;PXmcyPzR2N{e1NC=>
U937 MnnDT4lv[XOnIFHzd4F6 NUHSbI9WOSEQvF2= NFjnNXAzPCCq M3K2U2ROW09? NILt[|Jp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= M{PWW|E4PDR5N{Ww
PANC1 NVPNeop6TnWwY4Tpc44hSXO|YYm= MYGxJO69VQ>? M3frVFI1KGh? Mnny[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= M4mxb|E4PTh6N{S0
PANC1 NG\LZW5HfW6ldHnvckBCe3OjeR?= NY\EXpNtOSEQvF2= Mmn3OFghKGh? NXvocm5p\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NWDuWVdsOTd3OEi3OFQ>
Caco-2 NILTe21HfW6ldHnvckBCe3OjeR?= MUS1JO69VQ>? NGjC[nozPCCq NX3OOVZVTE2VTx?= NUnq[pg{\G:nczDuc5QhcW6mdXPlJHAzOVeDRkGg[4Vv\SCneIDy[ZN{cW:w NFrBXWMzODF2M{i0NC=>
SCC4 NV7j[m1ZTnWwY4Tpc44hSXO|YYm= M1:yVFEh|ryP NGH0WmQyOCCvaX6= NXvwNYU3TE2VTx?= NEXwbFdp[XNibn:gZYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= MXmyNFQ2OjJ{NR?=
A549 NWixcngzTnWwY4Tpc44hSXO|YYm= MVO1JO69VQ>? MXezJIg> NUG1Uml4TE2VTx?= NWC3RoNi\G:nczDuc5QhcW6mdXPlJIF2fG:yaHHnfUBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|NKUQ>? M4C3VVIxQDV3MkC4
HCT116 MYHLbY5ie2ViQYPzZZk> MXmwMlMh|ryP M4LSSFMxKGh? M3[4N2ROW09? M{TGXoRw\XNibn;0JIlvcGmkaYSgTGRCSzFiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKGirc4TvcoUhUDONOTDhZ4V1gWyjdHnvci=> NUnrfGFmOjFyOEC2OFc>
HepG2 MV\GeY5kfGmxbjDBd5NigQ>? NY\4XZYxOTBizszN NUniT3kxOjRiaB?= NYC2UnROTE2VTx?= NV\vXJVL\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCqeYDldoFk\XS7bHH0bY9vKG:oIIC1Ny=> MmHvNlE2PDh3OEK=
GM11272 NIW0WmZHfW6ldHnvckBCe3OjeR?= NWLoVJJpOC5zIN88US=> NIPUXYE4OiCq NVvlXJVPTE2VTx?= NHfDNXhld2W|IH7veEBz\WGldHn2ZZRmKE2nQ4CyJI12fGGwdDDlfJBz\XO|aX;u MY[yNVg1ODdzNh?=
MDA-MB-231 M376NGtqdmG|ZTDBd5NigQ>? MmewNVAh|ryP NUTYW2Q6PSCvaX6= M2r0U2ROW09? MVfkc4V{KG6xdDDpcohq[mm2IFjERWMz[Q>? NHTGSnYzOzR7M{S0PS=>
MDA-MB-231 NYf5d4VxU2mwYYPlJGF{e2G7 MXuxJO69VQ>? M2PacVI1KGh? MVzEUXNQ NI\xZYZld2W|IH7veEBqdmirYnn0JGhFSUN4IHHzd4V{e2WmIHHzJIFk\XS7bHH0bY9vKGyndnXsd{Bw\iC2dXL1cIlv NEDkXJIzOzR7M{S0PS=>
K562 NFH2SJlMcW6jc3WgRZN{[Xl? NWXLeHpu\G:nczDuc5QhcW6qaXLpeEBJTEGF M{LLPFI{PTlzMUGx
Jurkat MWDDfZRwfG:6aXOgRZN{[Xl? MoriNlAh|ryP M2W1TFczKGh? MlK4SG1UVw>? MYLuc{BkgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36= MUOyOFMxPDN2OB?=
HCT116 M2XqbmFxd3C2b4Ppd{BCe3OjeR?= M13FeVMh|ryP MmjwNlQhcA>? NFvn[G9FVVOR M4jXToRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icEWzJJBzd3SnaX6gcIV3\Wx? M2PCVFI1PzZ4NU[w
KASUMI-1 M2nhNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX4eXZKSzVyPUm5MlE4KG6P M1v4fnNCVkeHUh?=
KARPAS-45 MnzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf0TnpKSzVyPUG3N{45QSCwTR?= Mm\UV2FPT0WU
BHT-101 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTNTWM2OD1{NESuNVghdk1? NUD3R5A6W0GQR1XS
H9 NGTUeVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfmTWM2OD1{NUWuNFQhdk1? M{XsSHNCVkeHUh?=
PA-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ6Nj6yOkBvVQ>? NXGzNW97W0GQR1XS
NEC8 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fEO2lEPTB;Mki5MlM5KG6P MV3TRW5ITVJ?
MHH-PREB-1 NIjtRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvvTWM2OD1{OUSuOVMhdk1? MXrTRW5ITVJ?
NB7 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NECwPFdKSzVyPUO0OU44PCCwTR?= NHPBZmlUSU6JRWK=
A3-KAW MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T5PWlEPTB;NECwMlU6KG6P M1\QZ3NCVkeHUh?=
NB69 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDF[4FEUUN3ME20NVEvPzFibl2= MV7TRW5ITVJ?
EoL-1-cell NHXyUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TEOmlEPTB;NEW0NlUhdk1? Mo\tV2FPT0WU
CHP-212 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPITWM2OD12NUeuOVMhdk1? NX\3dJc6W0GQR1XS
C2BBe1 NFHjXnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K3TWlEPTB;NEeyMlE6KG6P NVHHblA3W0GQR1XS
697 M4Xjd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nVPGlEPTB;NEezMlQyKG6P NWjGNFBzW0GQR1XS
BCPAP M{mzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjoTWM2OD13MEGuOFIhdk1? M4CycnNCVkeHUh?=
L-363 NU[zepJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLmTWM2OD13MEOuNUBvVQ>? M3nUUnNCVkeHUh?=
ES8 NIrvT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vxU2lEPTB;NUKzMlU{KG6P NH;ZcpdUSU6JRWK=
BE-13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrmUpRRUUN3ME21NlYvQTZibl2= M1H0e3NCVkeHUh?=
CTB-1 NILURZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHDTWM2OD13M{euPVIhdk1? NF:wWZlUSU6JRWK=
HD-MY-Z NX3nRVBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTV|OD6xN{BvVQ>? M2rLcHNCVkeHUh?=
NKM-1 M3zUZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLRTWM2OD13NESuNlchdk1? MlzSV2FPT0WU
NCI-H720 M3\Zcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrkTWM2OD13NkCuNVghdk1? MWHTRW5ITVJ?
KY821 NX3mXI9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonZTWM2OD13NkOuNlUhdk1? M1vscXNCVkeHUh?=
OVCAR-5 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnCeFZKSzVyPUW3Ok4yOSCwTR?= Ml7BV2FPT0WU
CTV-1 MlPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTV6MT61OkBvVQ>? NUnHPYJNW0GQR1XS
P12-ICHIKAWA MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTrZ2p{UUN3ME21PVYvPTFibl2= NH;HVoJUSU6JRWK=
DB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLvXG5YUUN3ME21PVgvPTdibl2= M1f2XnNCVkeHUh?=
CHL-1 MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvaTWM2OD14NEKuNFghdk1? NYCzXG5JW0GQR1XS
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COLO-320-HSR MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe3RnZ4UUN3ME2xMlg5OTl5IN88US=> NU\yN5NnW0GQR1XS
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HL-60 M3jNRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfiTWM2OD1zLkmzPVAzKM7:TR?= NW\NXXRIW0GQR1XS
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A101D MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnVTZY4UUN3ME2yMlIxOzB|IN88US=> MkjEV2FPT0WU
NCI-H446 NHHSbohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJwMES1PVkh|ryP M4HaPHNCVkeHUh?=
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DMS-273 NVy0[WxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJwMUS4N|ch|ryP M3LsNXNCVkeHUh?=
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NCI-H1666 NIi2N2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3w[|lsUUN3ME2yMlI5OTFzIN88US=> MmGxV2FPT0WU
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JAR M3PybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzZOmg3UUN3ME2yMlMyQTh5IN88US=> NYrpXWNTW0GQR1XS
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GB-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fNN2lEPTB;Mj6zNlM{PSEQvF2= MVPTRW5ITVJ?
KP-N-YS MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJwM{K2NVUh|ryP MnvvV2FPT0WU
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RH-18 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPDd48{UUN3ME2yMlM2ODJ{IN88US=> NVO4UGR3W0GQR1XS
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HSC-3 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fufmlEPTB;Mj60OFUxQSEQvF2= NHe3W2RUSU6JRWK=
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LU-134-A M3vaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PV[mlEPTB;Mj60O|AxQCEQvF2= NHnJUJBUSU6JRWK=
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NCI-H2170 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7MWG5CUUN3ME2yMlUxPTR7IN88US=> M3fDfXNCVkeHUh?=
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NCI-H510A M2HkOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq3c4VKSzVyPUKuOlQ1OjZizszN MX7TRW5ITVJ?
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SNU-449 MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn34TWM2OD1{Lki5NVgzKM7:TR?= NXz4fnZIW0GQR1XS
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NCI-H810 Mn:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrMTWM2OD1|LkC0PFI{KM7:TR?= NIXs[ppUSU6JRWK=
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T-24 M{iwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\3RppKSzVyPUOuNVUxPyEQvF2= MlzQV2FPT0WU
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LB2518-MEL M{jUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33r[2lEPTB;Mz6yNlM6QCEQvF2= MlLLV2FPT0WU
T47D M3roO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jhRmlEPTB;Mz6yN|YzPyEQvF2= NH3kR|JUSU6JRWK=
NCI-H1651 NF3POmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWwflFKSzVyPUOuNlQ3PDRizszN NXzVe3lwW0GQR1XS
EC-GI-10 NG\sO2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXqW|BKSzVyPUOuNlYyPTNizszN MYrTRW5ITVJ?
HT-29 NX6xcIFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXJPJlZUUN3ME2zMlI3PjF2IN88US=> MlrzV2FPT0WU
GI-ME-N MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13OR2lEPTB;Mz6yPVUyOSEQvF2= MYDTRW5ITVJ?
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RKO MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jW[WlEPTB;Mz6zNFc2PyEQvF2= MVLTRW5ITVJ?
NCI-H1563 MlHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnGW|hKSzVyPUOuN|MxOThizszN NVPOS3U1W0GQR1XS
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NCI-H82 M4DlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HzcWlEPTB;Mk[uOFI5QCEQvF2= M4DmOXNCVkeHUh?=
COLO-678 NVixWGt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnviTWM2OD1{Nz60PVE6KM7:TR?= NYm0NnJYW0GQR1XS
KURAMOCHI MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHnNHZkUUN3ME2yPE4yOjZizszN MmL6V2FPT0WU
NCI-H1650 M4LQW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PqOGlEPTB;M{CuNVkzPCEQvF2= NVjENo5LW0GQR1XS
HCC1954 Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrUN2MyUUN3ME2zNU4{PjZ4IN88US=> NYfYXYk4W0GQR1XS
GAK NWHiWG9WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN{LkK2NVYh|ryP M2HTcnNCVkeHUh?=
YAPC MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrVeHFKSzVyPUOzMlc3PDhizszN NEO1Sm5USU6JRWK=
NCI-H2228 NITWS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HzemlEPTB;M{SuN|YxPSEQvF2= MX;TRW5ITVJ?
VMRC-RCZ M3HqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN4LkOwNlIh|ryP M2nLdHNCVkeHUh?=
NMC-G1 NULQSHBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;tbXpKSzVyPUO3MlA2OjlizszN Mn7CV2FPT0WU
D-336MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPJRmdKSzVyPUSxMlg1PDJizszN NGrIUY9USU6JRWK=
UACC-62 NUPzWFg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH6TWM2OD12Mj61OVA2KM7:TR?= M1XD[XNCVkeHUh?=
C-33-A NEL6UndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPCTWM2OD12NT6zNlU3KM7:TR?= NGTMR|dUSU6JRWK=
HCC1937 MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYKxU4VLUUN3ME20O{4yQTV6IN88US=> MWrTRW5ITVJ?
HDLM-2 M2\QUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;ZemlEPTB;NEeuNlI5PyEQvF2= NGm4e5FUSU6JRWK=
NCI-H727 MoTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTR5LkK0OVEh|ryP NH[xdoZUSU6JRWK=
NY MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\aTWM2OD12OT6zPVA5KM7:TR?= M1XidnNCVkeHUh?=
NCI-H2291 NV3yVHVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHryR4ZKSzVyPUS5Mlg{ODFizszN NInSUlNUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center July 2019 Early Phase 1
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center July 2019 Early Phase 1
NCT03843528 Not yet recruiting Acute Myeloid Leukemia|Myelodysplastic Syndromes|Mixed Phenotype Acute Leukemia|Juvenile Myelomonocytic Leukemia Johns Hopkins All Children''s Hospital May 1 2019 Phase 1
NCT03843528 Not yet recruiting Acute Myeloid Leukemia|Myelodysplastic Syndromes|Mixed Phenotype Acute Leukemia|Juvenile Myelomonocytic Leukemia Johns Hopkins All Children''s Hospital May 1 2019 Phase 1
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System April 1 2019 Phase 1
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System April 1 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID