Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 100 Publications

20 Customer Reviews

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M2L0PGtqdmG|ZTDBd5NigQ>? NVu4XXZkOSCq MX;EUXNQ Mn[0ZY51cS2KRFHDNUBi[3Srdnn0fUB4cXSqIFnDOVAhd2ZiMD6xNVIh|ryP MYexNVk3ODR6OR?=
Friend leukemic cell MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIO5eXg2OCEQvF2= Ml;LO|IhcA>? Mnm0SG1UVw>? MVzJR|UxRTBwOUmg{txO M3PXflEzOTB7OUGz
K562 NEjmeVJMcW6jc3WgRZN{[Xl? NVmwXFNxPiCq NWjzV2lOTE2VTx?= MXTJcohq[mm2aX;uJI9nKGi3bXHuJIhqe3SxbnWg[IVi[2W2eXzhd4UhMG2reIT1doUhd2ZiSFTBR|Eh[W6mIFjERWMzMSC5aYToJGlEPTBib3[gNE4xOSEQvF2= MkjDNVI1OTl|OEC=
HT1080 NYPwWHNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnybG04OiCq MlzrSG1UVw>? MojiTWM2OD1{LkSg{txO M1r5XFEzOjdyMUe1
H1299 MYTLbY5ie2ViQYPzZZk> MY[yNEBucW5? MYXEUXNQ MmDjTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= M2GxXVE1PTJzNEKy
H1299 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEO2Xlg4OiCq MX3EUXNQ MU\JR|UxRTdwMkSg{txO M3ywSlE1PTJzNEKy
HeLa MmSzT4lv[XOnIFHzd4F6 NHTHc|U{OCCvaX6= MYPJcohq[mm2b4L5JINwdmOnboTyZZRqd25iYXfhbY5{fCCqaYP0c45mKGSnYXPleJlt[XOnIIfpeIghUUN3MDDv[kAxNjJ6IN88US=> NXfWUYJEOTV4MEO5OFk>
LOX-IMVI M{\Ldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXuycXlWPDhiaB?= M{\XSGlEPTB;MT6zJO69VQ>? NEnYN4EyPTdzNUS3NC=>
NCI-H226 NX\DUmo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLmOFghcA>? M{LxUWlEPTB;Mj62JO69VQ>? NHm4SYsyPTdzNUS3NC=>
RXF-631L MlHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7mOFghcA>? M4fKemlEPTB;MjFOwG0> MmfUNVU4OTV2N{C=
SNB-78 MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nBcFQ5KGh? NV;MO4p3UUN3ME2xOkDPxE1? NFHNU28yPTdzNUS3NC=>
St-4 NGfMWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX63bYQ5PDhiaB?= MmPZTWM2OD13LkKg{txO M1zsb|E2PzF3NEew
ARP1 NF34[XpHfW6ldHnvckBCe3OjeR?= NUX1SHBPOiEQvF2= NVK2XFZQPiCq NWHKdmExUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NHS1VpYyPDd|NEiwOi=>
CEM M2PDVGtqdmG|ZTDBd5NigQ>? MUWxJIg> NXnjSXhCTE2VTx?= MWfJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO MXSxOlQzODB4NB?=
HCT15 NGi3bXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWK0PEBp NXjMfIg5T0l3ME2wMlgzKM7:TR?= MVWxOlczOzJ{Nx?=
NCI-H23 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPCOFghcA>? M1e1V2dKPTB;MD65NkDPxE1? MmGwNVY4OjN{Mke=
GM15850 MlfJT4lv[XOnIFHzd4F6 MV2yMlUh|ryP M4jkTlk3KGh? MUfEUXNQ MmP4TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n Mmj3NVY6OjF|Nke=
GM15850 Mn;CT4lv[XOnIFHzd4F6 M3O1XFIvPSEQvF2= NYjHeIV{QTZiaB?= MVzEUXNQ NF;rWlRKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NHu1eGkyPjl{MUO2Oy=>
GM15850 NHzITHVMcW6jc3WgRZN{[Xl? NFO3V2ozNjVizszN NGLSemM6PiCq NED3b49FVVOR Mme2TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NHXlPGQyPjl{MUO2Oy=>
GM15850 MmjnT4lv[XOnIFHzd4F6 MnfYNk42KM7:TR?= NXv3S|NbQTZiaB?= NH3pVXhFVVOR MV7Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViOTDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? MYqxOlkzOTN4Nx?=
GM15850 M17UUmtqdmG|ZTDBd5NigQ>? MoPQNk42KM7:TR?= MnPMPVYhcA>? NWnM[3B{TE2VTx?= NHniNWhKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NGLDSY0yPjl{MUO2Oy=>
GM15850 M1vFVGtqdmG|ZTDBd5NigQ>? Mki2Nk42KM7:TR?= Ml;oPVYhcA>? NUjLU5hXTE2VTx?= MUHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MXuxOlkzOTN4Nx?=
U937 M{DrZ2Z2dmO2aX;uJGF{e2G7 NV\LN3BoPSEQvF2= MXyyOEBp MYjEUXNQ NXz1eo9CS2WubDDjfYNt\SCjcoLld5Qh[nliYXPjeY12dGG2aX;uJIF1KFNxR{KvUUBxcGG|ZR?= M2KxOVE4ODB2N{G4
H661 NGHOU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTOOFghcA>? NGHVfXpKSzVyPUGg{txO MkfLNVcyPTdyMEm=
U937 NYW1XItqTnWwY4Tpc44hSXO|YYm= NGTqXmk2KM7:TR?= M4TWelI1KGh? M{fH[mROW09? MUPJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w MofFNVc1PDd5NUC=
U937 M131XGZ2dmO2aX;uJGF{e2G7 NF7P[HEyKM7:TR?= NEPqbXQzPCCq MWnEUXNQ MoTDSYZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= NGLnc5gyPzR2N{e1NC=>
RAW264.7 MlzVSpVv[3Srb36gRZN{[Xl? M1e5VFExKM7:TR?= MmPvNlRp MUX3ZZRmeg>? Ml\QTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= MknyNVc1Pzd3MUi=
RAW264.7 MX3GeY5kfGmxbjDBd5NigQ>? NWrPZ4xPOTBizszN NH3TfZQzPGh? NHrMTIx4[XSnch?= Ml32TY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> MmTCNVc1Pzd3MUi=
SC9 M3nXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPSZWdRPDhiaB?= M{K3O2lEPTB;MD62NFYh|ryP NIj1T5kyPzVyN{KxPS=>
ST14A M2HRRmZ2dmO2aX;uJGF{e2G7 MXu1JI5O MYG3NkBp MVnJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u MmHFNVc2PjV7OUO=
ST14A MlW0SpVv[3Srb36gRZN{[Xl? NGjoWo02KG6P MVG3NkBp M4\Mb2lv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:w M17TSVE4PTZ3OUmz
PANC1 NFuxWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17WfFEh|ryP NFfNSZlKSzVyPUCuOFUh|ryP M4Hw[lE4PTh6N{S0
PANC1 NFvaNpBHfW6ldHnvckBCe3OjeR?= M1nZZ|Eh|ryP NGDSUlEzPCCq MYDJcoNz\WG|ZTDpckBxOjGZQV[xM2NKWDFiZ3Xu[UBmgHC{ZYPzbY9v M17qNlE4PTh6N{S0
PANC1 M17YRWZ2dmO2aX;uJGF{e2G7 MmeyNUDPxE1? MmTQNlQhcA>? NVLuV3h[UW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NIjOPY0yPzV6OEe0OC=>
PT45 NFHkcJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHuTWM2OD12IN88US=> M{nr[|E4PTh6N{S0
ACHN M4e0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\FNlEhcA>? MWfHTVUxRTBwNkWg{txO Mo\ZNVc3PjJ4ME[=
PC3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6yNUBp Ml76S2k2OD1yLkexJO69VQ>? MVmxO|Y3OjZyNh?=
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SKHEP1 NXu0S3JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPscpRxPzJiaB?= M{jsXWlEPTB;Mz60OkDPxE1? M3f3cFIxOTR|N{e4
BJ MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjH[4p1OTByIN88US=> NYXFb|JRPDhiaB?= NVr2cYFVTE2VTx?= NEHwZpJIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> Mn;hNlAyPDN6NEC=
MUF M2jTZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfrOXdYOTByIN88US=> NHLP[3U1QCCq Mo\WSG1UVw>? NHTjR5lIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> M{jNPFIxOTR|OESw
Caco-2 M1nNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjDZY0yODBizszN M1HSW|Q5cA>? MWXEUXNQ MVzJR|UxRThwMTFOwG0> Mn;zNlAyPDN6NEC=
Caco-2 MkH1T4lv[XOnIFHzd4F6 MmjnOUDPxE1? MoHSOEBp MmS0SG1UVw>? M3XTVmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIhqe3SxbnWgZYNmfHmuYYTpc44hUUN3MDDv[kAxNjB|NzFOwG0> NX\YcWpROjBzNEO4OFA>
Caco-2 NInVPYJMcW6jc3WgRZN{[Xl? NYrIdGltOC5|MU[gcm0hfG9iM{GuOkDPxE1? Mor6OEBp NV;nfGhRTE2VTx?= NXT0XY0{TXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOxJJdqfGhiSVO1NEBw\iByLkGxPUDPxE1? MWWyNFE1Ozh2MB?=
Caco-2 Mln3T4lv[XOnIFHzd4F6 NYDCfGF5OC5|MU[gcm0hfG9iM{GuOkDPxE1? NUXzdZBUPCCq M13ZUWROW09? NX;mVmhMTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVOzJJdqfGhiSVO1NEBw\iByLkG0O{DPxE1? M2nDR|IxOTR|OESw
Caco-2 MWTLbY5ie2ViQYPzZZk> NV\iZpdEPi5|MjDuUUB1dyB4M{Kg{txO NGP2b5Y1KGh? NUniSW5UTE2VTx?= NXrQT3NvTXhidnn2c{BqdmirYnn0bY9vKG:oIHj1cYFvKEiGQVO1JJdqfGhiSVO1NEBw\iBzMj62JO69VQ>? NYfqPHh[OjBzNEO4OFA>
Caco-2 NYHTSoRiU2mwYYPlJGF{e2G7 MmnoOk4{OiCwTTD0c{A3OzJizszN NHvRUWo1KGh? MUDEUXNQ MYrFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzdid3n0bEBKSzVyIH;mJFQyKM7:TR?= NEnNfIQzODF2M{i0NC=>
Caco-2 MWnLbY5ie2ViQYPzZZk> M4LDWVAvOzF4IH7NJJRwKDNzLk[g{txO MlPkOEBp MmnWSG1UVw>? M3T1eGV5KH[rdn:gbY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNh?= NV\nPWxNOjBzNEO4OFA>
HepG2 MULLbY5ie2ViQYPzZZk> NE\peY42KM7:TR?= MV[2bC=> MX7EUXNQ MUnJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u MVGyNFE1Ozh2MB?=
HepG2 MVjLbY5ie2ViQYPzZZk> M2XuOVUh|ryP Mn;UOog> MULEUXNQ NXPyd|NrUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBpgXCncnHj[ZR6dGG2aX;u MYWyNFE1Ozh2MB?=
HepG2 NIXobVBMcW6jc3WgRZN{[Xl? M2\2e|Uh|ryP MYG2bC=> Mn;PSG1UVw>? MU\JcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w M3[4W|IxOTR|OESw
HepG2 MUjLbY5ie2ViQYPzZZk> NHvKOVQ2KM7:TR?= NYLrNmNNPmh? MmnCSG1UVw>? M1PoVGlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= MnO4NlAyPDN6NEC=
COLO205 NGH4VlJMcW6jc3WgRZN{[Xl? NVnkPWZSOTBizszN MV6yOEBp MWDEUXNQ NYXFZ3dtUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> M2LEZ|IxPDVzM{e4
SCC4 M3WzdmtqdmG|ZTDBd5NigQ>? NYTUUG5vOSEQvF2= NFT5dlUzPGh? Mm\KTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIT1ZpVtcW5iYXPleJlt[XSrb36= MkPBNlA1PTJ{MkW=
SCC4 MnvjT4lv[XOnIFHzd4F6 MmeyNUDPxE1? MnP2NlRp NXvQ[GVHUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgZYNmfHmuYYTpc44> NIK3clMzODR3MkKyOS=>
SCC4 M4L2bWZ2dmO2aX;uJGF{e2G7 NX7jNHdUOSEQvF2= M1PhN|UhdWmw NWfzS5ljSWexbnnzeEBi[3Srdnn0fUBifCCYRGKgZZN{\XO|ZXSgZZMhcW6mdXP0bY9vKG:oIFPZVFI1KGenbnWg[ZhxemW|c3nvci=> NIKyc4kzODR3MkKyOS=>
NB4 MnfqSpVv[3Srb36gRZN{[Xl? NWnaOGN6PSEQvF2= NF\tWHgzPCCq M{foO2ROW09? NGPiW2tE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4N2dXWuYYTpc44h[XRicILlMWcyKHCqYYPl MkDQNlA1QTF2NEC=
NB4 NYDxTlhHU2mwYYPlJGF{e2G7 NYe5XJQyPSEQvF2= MYWyOEBp MmXRSG1UVw>? MYXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPleJlt[XSnIIT1ZpVtcW5ibHX2[Yw> M3mwZlIxPDlzNESw
NB4 NWjxRY1uTnWwY4Tpc44hSXO|YYm= MoTmOUDPxE1? M2jHV|I1KGh? M122b2ROW09? M1j2T2lv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> Ml31NlA1QTF2NEC=
NB4 MlrzT4lv[XOnIFHzd4F6 MUK1JO69VQ>? M{my[|I1KGh? MlTSSG1UVw>? M3\Zc2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v NVTqd5ZwOjB2OUG0OFA>
NUGC3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrHTVUxRTJwOUSg{txO NUm5XXExOjB6NUC5O|E>
A549 M4r5TGZ2dmO2aX;uJGF{e2G7 M{\QfVUh|ryP M3vNT|MhcA>? M{\RR2ROW09? NXn0N4JxUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFzDN2lK M3n5fVIxQDV3MkC4
HUT78 NXK1dmJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC2VlQ4OiCq M4njVmROW09? M3roT2dKPTB;MD6zJO69VQ>? M{ThdlIxQDh2MkC4
U937 NE\4XnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LrSFczKGh? MVPEUXNQ NXPyV4FTT0l3ME2wMlM6KM7:TR?= NX;CS|hYOjB6OESyNFg>
A431 NYTB[GdoS3m2b4TvfIlkKEG|c3H5 MknEO|IhcA>? NX[4WJBlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTR|MTDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA1NjJizszN Mn6xNlExQDB4Mkm=
A549 M{TZSmN6fG:2b4jpZ{BCe3OjeR?= M3faN|czKGh? NV;CbGprS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjhizszN NV7CblBrOjFyOEC2Nlk>
CAL27 MmHzR5l1d3SxeHnjJGF{e2G7 NHrBZ3I4OiCq NH;JUGFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN NVzpd5JjOjFyOEC2Nlk>
HeLa NUnJc3lsS3m2b4TvfIlkKEG|c3H5 NFPNTYo4OiCq NH3Pe2JEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= NIjxS2UzOTB6ME[yPS=>
Sf21 NIHIc4pMcW6jc3WgRZN{[Xl? M2TrfFMhcA>? NXrF[WJ6UW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> MoPmNlExQDB4Mkm=
SKBR3 M4LPfGN6fG:2b4jpZ{BCe3OjeR?= NYTXNXB{PzJiaB?= M3nLdGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvPiEQvF2= NE\welEzOTB6ME[yPS=>
SKOV3 NYm1OWdTS3m2b4TvfIlkKEG|c3H5 MkO1O|IhcA>? M3zsTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= NHvhVZkzOTB6ME[yPS=>
COR-L23 M1PN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\HNVAh|ryP NYXs[YdiPzJiaB?= Ml;ISG1UVw>? NFvJdm9IUTVyPUGuNUDPxE1? NXS3cXVLOjFyOEC2OFc>
DU145 NEm2WZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rIWlExKM7:TR?= MYq3NkBp M1X0UWROW09? NX3ySXVKT0l3ME2xMlA2KM7:TR?= NG\HbWEzOTB6ME[0Oy=>
LoVo M1HFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfzNVAh|ryP NXfsdZVPPzJiaB?= MX\EUXNQ MVnHTVUxRTFwNzFOwG0> NV7VN2xWOjFyOEC2OFc>
MCR5-SV2 M2PvWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKxNEDPxE1? NGfoTWo4OiCq MlTmSG1UVw>? MWjHTVUxRTJwMTFOwG0> M3vBPFIyODhyNkS3
HCT116 M{Xqe2tqdmG|ZTDBd5NigQ>? M4mxV|MxKM7:TR?= M{T3W|MxKGh? MmnuSG1UVw>? MUDJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w MUGyNVA5ODZ2Nx?=
HCT116 M3PDemtqdmG|ZTDBd5NigQ>? NF3qelI{OCEQvF2= NVPVSlNiOzBiaB?= NH;0Ro9FVVOR MU\Jcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizT|kh[WOndInsZZRqd25? NWrkcZBiOjFyOEC2OFc>
U937 MXvLbY5ie2ViQYPzZZk> NUjpT2tWPSEQvF2= MmTQNlQhcA>? NXfFfZlSTE2VTx?= Mn20TY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? NFizTZAzOTJ7MkS5Ni=>
U937 NV;QZZprU2mwYYPlJGF{e2G7 M33hNFUh|ryP NXPkdFg6OjRiaB?= NUPkfVg1TE2VTx?= NV3teYwyUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{G4 NELMOlIzOTJ7MkS5Ni=>
U937 NYTIUnFoU2mwYYPlJGF{e2G7 NGfleIs2KM7:TR?= NFiyfJgzPCCq NHy5OWdFVVOR M3;LR2lvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu NX7Jd5NQOjF{OUK0PVI>
U937 MlnST4lv[XOnIFHzd4F6 NF70e|A2KM7:TR?= M33Wb|E2KG2rbh?= M1vXWGROW09? MUTJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiCuZY\lcC=> NIKyOWgzOTJ7MkS5Ni=>
A2780 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvkPVYhcA>? MlLqSG1UVw>? M3npRWlEPTB;MT62NkDPxE1? M3HFUlIyPjN2NEOw
COLO205 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTTR3M6PiCq M4D5SmROW09? MmTrTWM2OD1{LkGyJO69VQ>? MVyyNVY{PDR|MB?=
Hep3B M4PhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPFbmhbPDhiaB?= MlzhSG1UVw>? NYjORnFYT0l3ME2xMlIyKM7:TR?= NXPKRlZSOjF5MUKxOFY>
GM11272 MULGeY5kfGmxbjDBd5NigQ>? NYnVb4ZGOTByIH7N M{XlWlczKGh? MXPEUXNQ NIf4R2tT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O NYO2[4lVOjF6NEC3NVY>
CFBE41o NE\s[29McW6jc3WgRZN{[Xl? MlKzOUDPxE1? MX\EUXNQ M4rQTGRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? MlzmNlE6QDR7NUi=
CFBE41o MnLsSpVv[3Srb36gRZN{[Xl? NUK3cXJvOSEQvF2= M{TBU|I1KGh? MYfEUXNQ MUTS[ZN1d3KjdHnvckBw\iCFRmTSJIRmdHSjRkWwPEBufXSjboSgeJJi\m[rY3vpcochfG9iY3XscEB{fXKoYXPlJIF{KGeueXPv[o9zdXN? NH7WV|kzOTl6NEm1PC=>
DU145 M3P3dGtqdmG|ZTDBd5NigQ>? M2f4NlIvPSEQvF2= M2DPTVI1KGh? M1nZVmROW09? MXLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u MUSyNlI3ODF4Nh?=
DU145 MkLOT4lv[XOnIFHzd4F6 MoHFOUDPxE1? M3fFSFI1KGh? M3n6dGROW09? M2HoOWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u M2fPWVIzOjZyMU[2
DU145 Moq3T4lv[XOnIFHzd4F6 MlPxOUDPxE1? M1npPVI1KGh? MoqwSG1UVw>? M3LOUGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? NHjiNIQzOjJ4MEG2Oi=>
786-0 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;6c403NjJizszN NILqXZM4OiCq MVzEUXNQ MkDjS2k2OD1|LkKg{txO M3i0S|IzPDN3Nk[5
A498 NEHDOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS2RpI3NjJizszN NG\iVHY4OiCq MkDlSG1UVw>? MVHHTVUxRTFwNjFOwG0> M2TGflIzPDN3Nk[5
A549/ATCC NX\1TZVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDldZk3NjJizszN MYS3NkBp M2DETmROW09? NHOzVGdIUTVyPUGuOkDPxE1? NWfacotrOjJ2M{W2Olk>
ACHN MmX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH2d|hzPi5{IN88US=> M3P2VVczKGh? M4f4VWROW09? NHz1e|JIUTVyPUGuN{DPxE1? MX6yNlQ{PTZ4OR?=
BT549 NILVOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjWS3o3NjJizszN Mn3iO|IhcA>? Ml;uSG1UVw>? MUTHTVUxRTFwMzFOwG0> NWOwRlBDOjJ2M{W2Olk>
EKVX NUe5ZYdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr4XW9rPi5{IN88US=> M4DIcVczKGh? MnfQSG1UVw>? M1eyemdKPTB;MT6zJO69VQ>? NFPmZWczOjR|NU[2PS=>
HCT15 M3;WZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjjNFRnPi5{IN88US=> M3vWSFczKGh? MVTEUXNQ M3vyVmdKPTB;Mj61JO69VQ>? NVXMeG9nOjJ2M{W2Olk>
HOP92 NEj1elJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYi2MlIh|ryP Mom5O|IhcA>? MnvYSG1UVw>? NH7nO4lIUTVyPUSg{txO MUSyNlQ{PTZ4OR?=
IGROV1 M2DPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjpRlR6Pi5{IN88US=> NXTaN3JlPzJiaB?= MoqzSG1UVw>? M1:wcmdKPTB;MT6zJO69VQ>? MX:yNlQ{PTZ4OR?=
LOXIMVI NGLyPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUi2MlIh|ryP NFXvSXk4OiCq NVXmXY9FTE2VTx?= NGrndJNIUTVyPUGg{txO M1noXVIzPDN3Nk[5
M14 NInZXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrPVoM3NjJizszN NF3FfJg4OiCq NXGzXIpsTE2VTx?= NEXaNXRIUTVyPUGuN{DPxE1? MkPxNlI1OzV4Nkm=
MALME-3M NILBXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jQclYvOiEQvF2= NEDXWHQ4OiCq MkDoSG1UVw>? MnvjS2k2OD1yLkOyJO69VQ>? NGO3THczOjR|NU[2PS=>
MCF10A M4m0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPNOk4zKM7:TR?= M2\pSVQ5KGh? M3TRPWROW09? MlLuS2k2OD17Lk[g{txO NELiSoYzOjR|NU[2PS=>
MDA-MB-435 M2HFb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETlS2U3NjJizszN NYfzNHlpPzJiaB?= MYfEUXNQ MnOzS2k2OD1yLkWg{txO NI\jfYszOjR|NU[2PS=>
MDA-MB-468 M4HQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7UXW43NjJizszN NVTUZ3JQPzJiaB?= MULEUXNQ M{TC[GdKPTB;MD62N{DPxE1? Mn64NlI1OzV4Nkm=
MOLT4 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUG2MlIh|ryP M2D3V|czKGh? MmjySG1UVw>? MoTpS2k2OD1yLkSg{txO MUWyNlQ{PTZ4OR?=
NCI-ADR-RES NFLKSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nYO|YvOiEQvF2= MkPtO|IhcA>? NH7qNXNFVVOR Mli2S2k2OD1yLkG2JO69VQ>? M2\HfFIzPDN3Nk[5
NCI-H23 NFLqcGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\0XlYvOiEQvF2= M3jWRVczKGh? MWTEUXNQ MnTIS2k2OD1zIN88US=> NVnMNYRiOjJ2M{W2Olk>
NCI-H322M M1\YN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULyOWtQPi5{IN88US=> NIiyN|U4OiCq MmG4SG1UVw>? NIXXO4VIUTVyPUCuO|kh|ryP Mlr4NlI1OzV4Nkm=
NCI-H460 M1yyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLXOk4zKM7:TR?= NIfLdGI4OiCq M{LsWWROW09? NVHZOoM1T0l3ME2wMlc6KM7:TR?= M1u3PFIzPDN3Nk[5
NCI-H522 NWj6VGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfu[og3NjJizszN NF\NNJQ4OiCq NUTNbpRWTE2VTx?= NVfvOnFyT0l3ME2wMlUh|ryP MmHiNlI1OzV4Nkm=
OVCAR3 NEXIS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\pOk4zKM7:TR?= NGXCN284OiCq NGf2SYNFVVOR Mkj6S2k2OD1zLkOg{txO MWKyNlQ{PTZ4OR?=
OVCAR4 NG\we|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTwOk4zKM7:TR?= MYe3NkBp M{m3TmROW09? NFrrdGRIUTVyPUSg{txO MoH3NlI1OzV4Nkm=
OVCAR5 M4TENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nRd|YvOiEQvF2= NVLXWXpxPzJiaB?= M2rETGROW09? NU\MXZRVT0l3ME2wMlc6KM7:TR?= NVPnNXU2OjJ2M{W2Olk>
OVCAR8 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7tRmdZPi5{IN88US=> MXW3NkBp M{TzNWROW09? M3XKSmdKPTB;MD61JO69VQ>? MUSyNlQ{PTZ4OR?=
RXF393 M{fuR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP2bGtSPi5{IN88US=> M3mzS|czKGh? NV20WVJkTE2VTx?= NEnEU3pIUTVyPUGuN{DPxE1? NWjEdFdCOjJ2M{W2Olk>
SF268 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm1Ok4zKM7:TR?= NX;ZflVYPzJiaB?= M3fzcWROW09? Mmn5S2k2OD1zLk[g{txO MVOyNlQ{PTZ4OR?=
SF295 M2DJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHaXYg3NjJizszN MVi3NkBp NYDRXnRKTE2VTx?= MVLHTVUxRTFwNjFOwG0> M4S5b|IzPDN3Nk[5
SF539 NFf4ZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTObpdGPi5{IN88US=> NYHQUHpVPzJiaB?= MU\EUXNQ M{TRSGdKPTB;MjFOwG0> MYeyNlQ{PTZ4OR?=
SK-MEL-2 NGS3U4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYe2MlIh|ryP M3nybFczKGh? NIXXPWlFVVOR M1u1SmdKPTB;MT6zJO69VQ>? MofsNlI1OzV4Nkm=
SK-MEL-28 M3y4WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXp[XM3NjJizszN M3LLPVczKGh? MVTEUXNQ MnHRS2k2OD1zIN88US=> MXWyNlQ{PTZ4OR?=
SK-MEL-5 Mnu3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LLUFYvOiEQvF2= NFvpbWs4OiCq MlP6SG1UVw>? MUnHTVUxRTBwNkOg{txO MoLCNlI1OzV4Nkm=
SKOV3 NFfKWYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG5cnRPPi5{IN88US=> NFLpcYs4OiCq MWfEUXNQ NUDESHdqT0l3ME2xJO69VQ>? MmLvNlI1OzV4Nkm=
SN12C M{DtUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;Qb5pkPi5{IN88US=> NFvpNoQ4OiCq M3vOTWROW09? NI\Z[opIUTVyPUKg{txO NYfGV3NoOjJ2M{W2Olk>
SNB19 M2fMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUi2MlIh|ryP MYe3NkBp MUjEUXNQ MnrCS2k2OD1yLk[zJO69VQ>? M2\sWlIzPDN3Nk[5
SNB75 NGfSc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXy2MlIh|ryP MWW3NkBp NIPoeIdFVVOR M2juO2dKPTB;MD63PUDPxE1? MnPuNlI1OzV4Nkm=
SR M4DCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TCWlYvOiEQvF2= NIPxUYY4OiCq MUDEUXNQ NHfoSnRIUTVyPUCuOEDPxE1? NYXKOXBKOjJ2M{W2Olk>
T47D NWLDWWhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3iWGl1Pi5{IN88US=> M1fQSlczKGh? M37jUmROW09? NF6ybIdIUTVyPUCuOUDPxE1? NVfHcYJmOjJ2M{W2Olk>
TK10 NEPFNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG4Ok4zKM7:TR?= NFnVeno4OiCq NVPDfYxmTE2VTx?= MUXHTVUxRTBwNkOg{txO MV2yNlQ{PTZ4OR?=
UACC257 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXO2MlIh|ryP M2Dpc|czKGh? NILTeYhFVVOR MkDtS2k2OD1yLkWg{txO M13SfFIzPDN3Nk[5
UACC62 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnqOk4zKM7:TR?= NYf3NZJ1PzJiaB?= NWXkRWgyTE2VTx?= M4noeWdKPTB;MD60JO69VQ>? MYGyNlQ{PTZ4OR?=
UO31 NYHzZ2VvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUm2MlIh|ryP MnL2O|IhcA>? MknoSG1UVw>? M{LFT2dKPTB;MD61JO69VQ>? MVqyNlQ{PTZ4OR?=
Hep3B MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWq0PEBp NHH3Z4NFVVOR MlvxS2k2OD1yLk[5JO69VQ>? NXn3T4F1OjJ2M{m4OlM>
BE(2)-C MmfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHvO|IhcA>? Mnn3SG1UVw>? MmHBTWM4OD1{IN88US=> NF;uO2UzOjl|MkOxOi=>
Bel7402 Mk\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Ppe|czKGh? NH3RXmtFVVOR MWfHTVkxRTF5IN88US=> NWnwR4ZyOjNyNkGzO|Y>
Bel7404 NFGyUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T1PFczKGh? MWPEUXNQ Ml\YS2k6OD1zODFOwG0> MoToNlMxPjF|N{[=
BGC823 NIjnUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X1clczKGh? NHThellFVVOR NF7lemlIUTlyPUeuOUDPxE1? MmXrNlMxPjF|N{[=
MGC803 NV3RVXl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXDNGR1PzJiaB?= NV76cnI3TE2VTx?= NXiwVG1UT0l7ME2xNE45KM7:TR?= NVXDTW96OjNyNkGzO|Y>
SGC7901 NUi5[HJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfndJlyPzJiaB?= NYLLUWI2TE2VTx?= NF\Q[YNIUTlyPUmuOEDPxE1? MV2yN|A3OTN5Nh?=
SKHEP1 NWTPW|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXaO|IhcA>? NEHCZmhFVVOR NYTxW5pST0l7ME2xO{DPxE1? NULyemRZOjNyNkGzO|Y>
SMMC7721 NUPHPZJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:3NkBp M3PUdmROW09? MWnHTVkxRTJyIN88US=> MUWyN|A3OTN5Nh?=
NUGC3 MnnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV:xNEDPxE1? NUXRWlFqT0l;Mj65OEDPxE1? MWSyN|E3OzN|Mh?=
A2780 CisR NHvDWmJMcW6jc3WgRZN{[Xl? M{O0XlE5KGh? NXvTSmhSUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M{LMXVI{OjV{NkCz
CAL27 sens MnznT4lv[XOnIFHzd4F6 M2H4fVE5KGh? NX7iTZVkUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= M2H6TlI{OjV{NkCz
CAL27 CisR MWLLbY5ie2ViQYPzZZk> M4nCUlE5KGh? MoLSTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NYjle|VOOjN{NUK2NFM>
KYSE-510 CisR MonvT4lv[XOnIFHzd4F6 MVmxPEBp MUDJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO NVLR[lFGOjN{NUK2NFM>
KYSE-510 sens NWryb29YU2mwYYPlJGF{e2G7 MnrjNVghcA>? NVLPNZpJUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP M1\aXVI{OjV{NkCz
MDA-MB-231 sens M3q3O2tqdmG|ZTDBd5NigQ>? MmLmNVghcA>? MVHJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NWfFU2RKOjN{NUK2NFM>
MDA-MB-231 CisR M{DIdGtqdmG|ZTDBd5NigQ>? NX3lcWk5OThiaB?= M4jrZWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NH\3VYMzOzJ3Mk[wNy=>
ES2 NGjoeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvLbmo1QCCq NVz1dVJKTE2VTx?= MYXJR|UxRTF{Lkeg{txO NInPfpIzOzR7M{S0PS=>
MDA-MB-231 NYOzOYoxU2mwYYPlJGF{e2G7 M{LXNlExKM7:TR?= MkHTN|AhdWmw MYPEUXNQ NIrabW1KdmirYnn0bY9vKG:oIFjERWMz[Q>? M4HJXVI{PDl|NES5
MDA-MB-231 NVrkboRvU2mwYYPlJGF{e2G7 MkfhNUDPxE1? Ml3xNlQhcA>? NXLFZ3VWTE2VTx?= MWjJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw NILM[FUzOzR7M{S0PS=>
HS68 Mnm5R5l1d3SxeHnjJGF{e2G7 MoP5NVAh|ryP MVi3NkBp MnLTSG1UVw>? M{XlcGlEPTB;ND62JO69VQ>? MWGyN|U4ODV2Mh?=
MEF NFf6NVlEgXSxdH;4bYMhSXO|YYm= MVyxNEDPxE1? NIm1UFM4OiCq MkW3SG1UVw>? Mk\oTWM2OD12LkSg{txO MnPDNlM2PzB3NEK=
BGC823 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\lSm1FVVOR MWHHTVUxRTNwMEmg{txO NVvmXIVjOjN4MEG3NFY>
High5 NWfJOGx7U2mwYYPlJGF{e2G7 NVHkVVYzOjRiaB?= MnLPTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDOkB4cXSqIFnDOVAhd2ZiMD6wPUDPxE1? MWSyN|YxOjV{Mx?=
High5 NEDK[FhMcW6jc3WgRZN{[Xl? MlvVNlQhcA>? NVi0XHNRUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOSC5aYToJGlEPTBib3[gNE4yOiEQvF2= NVjuZWJtOjN4MEK1NlM>
High5 M1fyd2tqdmG|ZTDBd5NigQ>? MWqyOEBp M4i3VmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP M2\xdVI{PjB{NUKz
A549 M162NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPEUXNQ NYHiZmlZUUN3ME2xMlA4QSEQvF2= NGS3R|QzOzZ2NEKxNC=>
HCT116 NEfLepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zT[2ROW09? MmTMTWM2OD1yLke1O{DPxE1? MlT0NlM3PDR{MUC=
K562 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYKzbm16TE2VTx?= MVjJR|UxRTBwNkS1JO69VQ>? Mn;kNlM3PDR{MUC=
GBC-SD MknkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[1JO69VQ>? MmDrO|IhcA>? Mlr6SG1UVw>? NGq5d3ZKSzVyPUG0Mlgh|ryP MnfpNlM4ODd{NkC=
HGC27 NGn0RodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYq1JO69VQ>? M4H2NVczKGh? NFPMW5pFVVOR NHHsR5hKSzVyPUWuOEDPxE1? NUfxbZJrOjN5MEeyOlA>
HL60 MWHLbY5ie2ViQYPzZZk> Mn[3OUDPxE1? NEH2SnYzPCCq Mn7KSG1UVw>? NUPMRmVwUW6qaXLpeIlwdiCxZjDISGFE MViyN|cxPzJ4MB?=
Vero M4rMVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XpdFczKGh? MXLEUXNQ NVPFS|dCUUN3ME2wMlkh|ryP MnXVNlM4QDZ2NUK=
NCI60 MoWyR5l1d3SxeHnjJGF{e2G7 MYK0PEBp NHzqNXhFVVOR NXHOdJNCT0l;MD61N{DPxE1? MoTVNlQxOTV|Mke=
SW620 MVvDfZRwfG:6aXOgRZN{[Xl? M2D0U|Q5KGh? NHnacoRFVVOR M4DQcWdKRTBwNUSg{txO MmP6NlQxOTV|Mke=
U251 MmrWR5l1d3SxeHnjJGF{e2G7 M3nCVVQ5KGh? MVjEUXNQ NFXuVGFIUT1zLkWzJO69VQ>? MUWyOFAyPTN{Nx?=
KM12 M1P1XGN6fG:2b4jpZ{BCe3OjeR?= M3PwZlQ5KGh? NGLYRnlFVVOR MoDES2k:OS56ODFOwG0> MoewNlQxOTV|Mke=
Hs578T MnKyR5l1d3SxeHnjJGF{e2G7 NXTLTZA2PDhiaB?= MWjEUXNQ NETqfINIUT12LkizJO69VQ>? NILlSFAzPDBzNUOyOy=>
MDA-MB-231 NFvUeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P5dVQ5KGh? Mk\OTWM2OD1yLkG2JO69VQ>? NUn5TFhPOjRyOUWwNVY>
MCF7 NGHPXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVu0PEBp NXHuS|R[T0l;MD60OUDPxE1? NUjsR|lvOjRzMUm1OVU>
MDA-MB-435 Mn\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULCc4VDPDhiaB?= NH[2UnFIUT1yLki4JO69VQ>? MUSyOFEyQTV3NR?=
AsPC1 NEO4d3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\1N|Ah|ryP MUi0PEBp M{LFbWROW09? NF\BWFRKSzVyPUOuOlYh|ryP NE\ucJkzPDF6NUO3PC=>
Jurkat E6.1 NGrhN|hMcW6jc3WgRZN{[Xl? M2nPSVIhcA>? Mn72SG1UVw>? MYrJcohq[mm2aX;uJI9nKEiGQVO0JJdqfGhiSVO1NEBw\iByLkC0JO69VQ>? NGfwb5MzPDJ4MUi2Ni=>
KG1 NX\jV2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXCcGI1QCCq NIG1W4VKSzVyPUGuNVUh|ryP NG[yZZIzPDV{NUCwNy=>
HEL NULYc2hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TzbVQ5KGh? NHTvNndFVVOR MWDJR|UxRTBwNEmg{txO NWPkb4J{OjR4OUSwOVU>
HSC3 MUPDfZRwfG:6aXOgRZN{[Xl? NFv2cIUyOiCq MoXNSG1UVw>? Ml63TWM2OD1yLkexJO69VQ>? MUeyOFc3PjV4MB?=
HT-29 NIjRUohEgXSxdH;4bYMhSXO|YYm= NGn6fHUyOiCq M1O5OmROW09? MknlTWM2OD1yLkeyJO69VQ>? NXLscIZrOjR5Nk[1OlA>
KB MmD2R5l1d3SxeHnjJGF{e2G7 MX[xNkBp MnPjSG1UVw>? M2Htd2lEPTB;MD63OUDPxE1? MmrFNlQ4PjZ3NkC=
H460 NIj4O2FEgXSxdH;4bYMhSXO|YYm= NX7QT2xCOTJiaB?= MXjEUXNQ MlfDTWM2OD1yLkiyJO69VQ>? NGKxRWYzPDd4NkW2NC=>
MONE1 NWTXS282S3m2b4TvfIlkKEG|c3H5 NYXkXnhGOTJiaB?= NIHSR45FVVOR M17uVmlEPTB;MT6xPEDPxE1? NFPSPHUzPDd4NkW2NC=>
MKN45 NFyxfYVEgXSxdH;4bYMhSXO|YYm= M3zuN|EzKGh? M4[zSGROW09? NYDlO4xIUUN3ME2xMlI2KM7:TR?= NGf4OFczPDd4NkW2NC=>
TSGH NXfjSopXS3m2b4TvfIlkKEG|c3H5 MmSxNVIhcA>? NGHHfIVFVVOR MYPJR|UxRTJwMEmg{txO MU[yOFc3PjV4MB?=
HL60 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HrOVczKGh? NYXxdWFNTE2VTx?= NHHrOIxIUTVyPUCuPVMh|ryP M1L6[VI1QTByNUCw
HEK293 M2HhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWm3NkBp NFPYfHNFVVOR NEXKTIZIUTVyPUGzJO69VQ>? MlzxNlQ6ODB3MEC=
Jurkat MnfPR5l1d3SxeHnjJGF{e2G7 NEG3[IsyODBizszN NIHIZ|Y4OiCq M2fKbWdKPTB;MD65JO69VQ>? MVmyOFkxODd2Mx?=
GM15850 NH;vSZVMcW6jc3WgRZN{[Xl? NYjOfoZoOi53IN88US=> MnXDPVYhcA>? M{j6XmROW09? NUnjSno{\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDF2IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m MoLMNVY6OjF|Nke=
GM15850 MV3LbY5ie2ViQYPzZZk> M{\BblIvPSEQvF2= NFnkZlk6PiCq NG\LdJZFVVOR M1\jT4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXzOUYtWOTZ7MkGzOlc>
GM15850 NWrmeVl{U2mwYYPlJGF{e2G7 NVjhdHlKOi53IN88US=> MVO5OkBp MYLEUXNQ MoW3[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NEfVZY4yPjl{MUO2Oy=>
GM15850 M4HJVWtqdmG|ZTDBd5NigQ>? NH;TW4czNjVizszN M{HlXlk3KGh? MkPKSG1UVw>? NIfPe4Zld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MmjKNVY6OjF|Nke=
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GM15850 M3TVO2tqdmG|ZTDBd5NigQ>? MnP5Nk42KM7:TR?= MnzGPVYhcA>? NFTqVpNFVVOR NV35[ldb\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF4IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M3T2WlE3QTJzM{[3
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Jurkat NYjNSFQ3S3m2b4TvfIlkKEG|c3H5 MYKyNEDPxE1? NFHtelM4OiCq MV7EUXNQ NGLXfHBvdyCleYTveI95cWOrdImgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44> MnnQNlQ{ODR|NEi=
HCT116 M1TvcGFxd3C2b4Ppd{BCe3OjeR?= MWmzJO69VQ>? NYLseZFtOjRiaB?= MXnEUXNQ M3W4SYRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icEWzJJBzd3SnaX6gcIV3\Wx? NFT3bIMzPDd4NkW2NC=>
KASUMI-1 M{\vd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u1T2lEPTB;OUmuNVchdk1? MUfTRW5ITVJ?
KARPAS-45 M2foeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF5Mz64PUBvVQ>? MVHTRW5ITVJ?
BHT-101 NF\iZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP3WJdbUUN3ME2yOFQvOThibl2= M4Hj[XNCVkeHUh?=
H9 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jJR2lEPTB;MkW1MlA1KG6P MYXTRW5ITVJ?
PA-1 Mm\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e3UmlEPTB;Mki2MlI3KG6P Mlu1V2FPT0WU
NEC8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJ6OT6zPEBvVQ>? MkmxV2FPT0WU
MHH-PREB-1 NILEPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7aOlVsUUN3ME2yPVQvPTNibl2= Mo[1V2FPT0WU
NB7 NGPUcFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTwTWM2OD1|NEWuO|Qhdk1? NFTsb3lUSU6JRWK=
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NB69 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRzMT63NUBvVQ>? NUTBWIpUW0GQR1XS
EoL-1-cell MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrP[3E5UUN3ME20OVQzPSCwTR?= MoTkV2FPT0WU
CHP-212 NIqweHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17neGlEPTB;NEW3MlU{KG6P NVzrfYZDW0GQR1XS
C2BBe1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTR5Mj6xPUBvVQ>? MYLTRW5ITVJ?
697 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NICyZ5lKSzVyPUS3N{41OSCwTR?= NG[2[FdUSU6JRWK=
BCPAP NXnENoFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzrT5VKSzVyPUWwNU41OiCwTR?= MkjRV2FPT0WU
L-363 M2Czfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoX5TWM2OD13MEOuNUBvVQ>? M32zenNCVkeHUh?=
ES8 NIH0OXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfXZ4pEUUN3ME21NlMvPTNibl2= NH3xPXNUSU6JRWK=
BE-13 NVjmZZFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHWdmp3UUN3ME21NlYvQTZibl2= NHG2bGVUSU6JRWK=
CTB-1 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3vSFRPUUN3ME21N|cvQTJibl2= NH\UNHlUSU6JRWK=
HD-MY-Z NH65UJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofVTWM2OD13M{iuNVMhdk1? MnS0V2FPT0WU
NKM-1 M2myeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qw[mlEPTB;NUS0MlI4KG6P M3jiSXNCVkeHUh?=
NCI-H720 M1nMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;GOG5iUUN3ME21OlAvOThibl2= M1GxUXNCVkeHUh?=
KY821 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;RTWM2OD13NkOuNlUhdk1? NV7tSWJ3W0GQR1XS
OVCAR-5 NWLISWFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTV5Nj6xNUBvVQ>? NFXa[XNUSU6JRWK=
CTV-1 MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnoTWM2OD13OEGuOVYhdk1? NXnFPG1XW0GQR1XS
P12-ICHIKAWA MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDRRXhWUUN3ME21PVYvPTFibl2= MXrTRW5ITVJ?
DB MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPIS3NKSzVyPUW5PE42PyCwTR?= MYPTRW5ITVJ?
CHL-1 NFr4eZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDYWZFEUUN3ME22OFIvODhibl2= MX\TRW5ITVJ?
A4-Fuk M1j6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;LWmJKSzVyPU[0OE46OSCwTR?= M3TEXHNCVkeHUh?=
MV-4-11 NVTLOI16T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXpTWM2OD14NUmuNUBvVQ>? NVq2TpZQW0GQR1XS
RPMI-8226 MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETDZYVKSzVyPU[3PE4yQCCwTR?= M1fZd3NCVkeHUh?=
NB14 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnQdXhKSzVyPU[5Ok46PSCwTR?= MlXwV2FPT0WU
DOHH-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XKbmlEPTB;N{C2MlY5KG6P M{[ybXNCVkeHUh?=
D-423MG M2fQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH60UlNKSzVyPUewOk45QSCwTR?= NEWwbYNUSU6JRWK=
D-283MED MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\xSGFKSzVyPUexOE4yPCCwTR?= M3jHOHNCVkeHUh?=
ES1 NGPQS25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvMZ4hsUUN3ME23NlQvPCCwTR?= NXjtfnZbW0GQR1XS
GOTO NV7IeW1kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnmeINEUUN3ME23NlkvOTJibl2= MmDPV2FPT0WU
NCI-H209 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy0Noh7UUN3ME23NlkvQSCwTR?= MY\TRW5ITVJ?
MOLT-13 MlLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XCSWlEPTB;N{O4Mlk5KG6P MkG0V2FPT0WU
ATN-1 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3YdFhyUUN3ME23OFAvOjhibl2= MkLCV2FPT0WU
DU-4475 M4nwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknMTWM2OD15NUGuPVEhdk1? NGPyS5BUSU6JRWK=
NB10 NYjibZprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfRSGpKSzVyPUe1NU46OiCwTR?= MmfRV2FPT0WU
KG-1 NIPnTFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTVTWM2OD15N{WuOFUhdk1? MlruV2FPT0WU
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HEL NGnZ[ohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj1OpRKSzVyPUiwOk4xQCCwTR?= MWfTRW5ITVJ?
SK-MEL-2 NELROFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrjSWw{UUN3ME24NFkvPDRibl2= MkK0V2FPT0WU
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LU-139 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[zZ2lEPTB;OEKyMlg3KG6P M330cXNCVkeHUh?=
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D-566MG MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLhTWM2OD16M{iuOlIhdk1? MofVV2FPT0WU
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HCC2218 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXKPVd[UUN3ME25OVgvPDhibl2= MVnTRW5ITVJ?
HAL-01 NFTtSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonBTWM2OD17NkiuNFQhdk1? NYrndFQ2W0GQR1XS
RD NI\BZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjnRWh2UUN3ME25O|QvPDVibl2= NIjpTWdUSU6JRWK=
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ML-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\wTmlEPTB;MT6wNFQxPyEQvF2= M1WxeHNCVkeHUh?=
MEL-HO M4XVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFwMEC1PFIh|ryP NGq3e2NUSU6JRWK=
MS-1 M3v1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\qTWM2OD1zLkCwOlE4KM7:TR?= MVjTRW5ITVJ?
NCI-SNU-1 NVyzelZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFwMEKzN|Eh|ryP MX7TRW5ITVJ?
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MN-60 NGOz[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFwMEK2PEDPxE1? M3PxWXNCVkeHUh?=
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EFM-19 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXkTJdKSzVyPUGuNFQ5PzlizszN MV\TRW5ITVJ?
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NB13 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXDPW91UUN3ME2xMlA2PTBzIN88US=> NH;4dZdUSU6JRWK=
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U-2-OS NW[zOIttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jmVmlEPTB;MT6wO|kyOSEQvF2= MYjTRW5ITVJ?
NCI-H526 M4DPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\kTWM2OD1zLkC4NlkyKM7:TR?= Mn21V2FPT0WU
KMOE-2 M3P3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwMEm0NlIh|ryP MlG4V2FPT0WU
RCM-1 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFwMUKxNFIh|ryP MmTlV2FPT0WU
MC116 NVfXU3RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3oRZVKSzVyPUGuNVM3OjFizszN MlrsV2FPT0WU
NCI-H1092 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnlTWM2OD1zLkG1OFA3KM7:TR?= NGrSfnFUSU6JRWK=
EW-3 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTFwMUeyNVIh|ryP M2PabHNCVkeHUh?=
HCT-116 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT0R4RKSzVyPUGuNVc4PSEQvF2= M17o[nNCVkeHUh?=
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NCI-H2052 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;ZUmlEPTB;MUCuNVg5OiEQvF2= MV\TRW5ITVJ?
A375 M{DpVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\6dJNKSzVyPUGwMlI1PTJizszN MVHTRW5ITVJ?
HCC38 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHyTWM2OD1zMD6zNlIh|ryP MVrTRW5ITVJ?
LK-2 M{X0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7TcWNKSzVyPUGwMlQzODhizszN NELyUmNUSU6JRWK=
SF126 NEjubJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnsTWM2OD1zMD60O|I4KM7:TR?= M1rqW3NCVkeHUh?=
SK-MEL-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHvZZhKSzVyPUGwMlc5OzhizszN MlzkV2FPT0WU
ACN NVP4e3Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjLTFgxUUN3ME2xNE45Pjd7IN88US=> NUCzXYM2W0GQR1XS
BB30-HNC M{fEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFyLki3NVEh|ryP NEfOTZBUSU6JRWK=
NCI-H747 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PkXWlEPTB;MUCuPFc1PiEQvF2= M{HxcXNCVkeHUh?=
KYSE-150 NHi2OnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFzLkCzPFch|ryP MmfDV2FPT0WU
D-247MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq4bWpbUUN3ME2xNU4yODB7IN88US=> NUS5fZQyW0GQR1XS
BxPC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j6Z2lEPTB;MUGuN|c1PyEQvF2= M2\EVXNCVkeHUh?=
SK-MEL-30 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r4cWlEPTB;MUGuOFA4QSEQvF2= NYTuOIpoW0GQR1XS
CAS-1 MnjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjDeGJKSzVyPUGxMlQyODlizszN MYrTRW5ITVJ?
no-10 M1G2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPNTWM2OD1zMj6xNlE4KM7:TR?= M2PNNnNCVkeHUh?=
NCI-H2405 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTF{LkKwN|Yh|ryP MnGxV2FPT0WU
KGN M{j1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTF{LkK5NFEh|ryP NYnGR5ByW0GQR1XS
BB49-HNC NXP4U|VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj5OFZLUUN3ME2xNk4{QTV4IN88US=> NXHrZmlHW0GQR1XS
NCI-H1693 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH5TWFKSzVyPUGyMlU5OTZizszN MUfTRW5ITVJ?
RO82-W-1 M2Tpemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTSTWM2OD1zMz6wOlQ6KM7:TR?= MoLnV2FPT0WU
CAL-85-1 M3:yNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[5bmJKSzVyPUGzMlQ{QTlizszN MnLuV2FPT0WU
H-EMC-SS NEjDSoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XtW2lEPTB;MUOuPVExPCEQvF2= NILTb3RUSU6JRWK=
SW1783 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnocFlKSzVyPUG0MlI{QTFizszN NWTJbFhTW0GQR1XS
LB771-HNC MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHTZpd{UUN3ME2xOE41OTlizszN M3vUdnNCVkeHUh?=
HCC70 NVzn[nVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TYcmlEPTB;MUSuOFI{OyEQvF2= MmXnV2FPT0WU
KNS-81-FD NV7v[oRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHxTWM2OD1zND63NFQ2KM7:TR?= MYHTRW5ITVJ?
KYSE-520 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[xRmlEPTB;MUSuPVI4KM7:TR?= M3LuVnNCVkeHUh?=
TGBC24TKB M3v3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF2Lkm1N|kh|ryP MlzBV2FPT0WU
SNB75 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF3LkC3Nlkh|ryP NFG3RW5USU6JRWK=
SW872 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPsdphPUUN3ME2xOU4zOjF6IN88US=> M4C5cnNCVkeHUh?=
U031 NImzUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfWTWM2OD1zNT64NFI5KM7:TR?= NFX0PYRUSU6JRWK=
ChaGo-K-1 NYH6eGwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIS3VllKSzVyPUG1Mlg{PTlizszN MYfTRW5ITVJ?
NCI-H441 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;hTWM2OD1zNj6wNFM6KM7:TR?= MXLTRW5ITVJ?
TE-12 M3PBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF4LkG4O|Mh|ryP NIDjR5ZUSU6JRWK=
NCI-H1755 NGDCcWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHHSZZ1UUN3ME2xOk42PzNizszN M1nzW3NCVkeHUh?=
KNS-42 M132OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHWTWM2OD1zNj62OVg6KM7:TR?= Mn\XV2FPT0WU
SK-PN-DW NYnRZm53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXrTWM2OD1zNz60NlAyKM7:TR?= NEDCbZpUSU6JRWK=
NCI-H226 M1\xPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\VboI6UUN3ME2xO{46OzR3IN88US=> MXnTRW5ITVJ?
K-562 Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XDfGlEPTB;MUiuOlMyPyEQvF2= NXTyNVRbW0GQR1XS
A388 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX4XopwUUN3ME2xPU4xOzB|IN88US=> NGjqV|dUSU6JRWK=
ZR-75-30 NEPBcGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rjS2lEPTB;MUmuNFk3QCEQvF2= NWj5cHN{W0GQR1XS
LU-135 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF7LkK2N|Yh|ryP M{\kVXNCVkeHUh?=
NCI-H2029 Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF7Lk[wNlEh|ryP Ml7CV2FPT0WU
HT-1197 NWS0V4RMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX36SGxMUUN3ME2xPU46OjJ5IN88US=> M{mxUnNCVkeHUh?=
IGR-1 MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJyLkOxNVch|ryP Mk\JV2FPT0WU
U-87-MG NXyzcXJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJyLk[0NVMh|ryP MVXTRW5ITVJ?
NCI-H1304 NIH5T2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzCUWN1UUN3ME2yNE44PTBzIN88US=> MlrqV2FPT0WU
RCC10RGB MoG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX3TWM2OD1{MT6yPFI6KM7:TR?= MXnTRW5ITVJ?
NCI-H520 NYPsd3JpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfRPIZUUUN3ME2yNk44PjFzIN88US=> NIDoOWNUSU6JRWK=
SK-LU-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fUN2lEPTB;MkOuNFcyQCEQvF2= MmHVV2FPT0WU
UACC-893 NHTQTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz4TJNNUUN3ME2yN{4yODN6IN88US=> MW\TRW5ITVJ?
NCI-H2347 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW3dIJKSzVyPUKzMlI3PzRizszN MVzTRW5ITVJ?
U-118-MG MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjpWpRKSzVyPUKzMlczOTdizszN MoHCV2FPT0WU
NCI-H596 MoHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLlVWdKSzVyPUKzMlkxPTVizszN MorRV2FPT0WU
MZ1-PC M4TQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTJ2Lk[3OVkh|ryP MnTEV2FPT0WU
SW1417 M1H1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ3LkK0PVgh|ryP NIHJXHlUSU6JRWK=
NCI-H82 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfVbnpKSzVyPUK2MlQzQDhizszN NVnZcJF1W0GQR1XS
COLO-678 NFXFcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDBWZRXUUN3ME2yO{41QTF7IN88US=> NFf5c2FUSU6JRWK=
KURAMOCHI MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnLTWM2OD1{OD6xNlYh|ryP Mmf4V2FPT0WU
NCI-H1650 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzFZWQyUUN3ME2zNE4yQTJ2IN88US=> NYHnVXdNW0GQR1XS
HCC1954 NWOyUodYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkexTWM2OD1|MT6zOlY3KM7:TR?= NXrzVVVvW0GQR1XS
GAK MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnXcXJKSzVyPUOyMlI3OTZizszN NIOwOmVUSU6JRWK=
YAPC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXZTWM2OD1|Mz63OlQ5KM7:TR?= MUTTRW5ITVJ?
NCI-H2228 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrDUlB{UUN3ME2zOE4{PjB3IN88US=> MmjOV2FPT0WU
VMRC-RCZ M1vGNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHGfZRKSzVyPUO2MlMxOjJizszN M1HZUnNCVkeHUh?=
NMC-G1 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLnTnV5UUN3ME2zO{4xPTJ7IN88US=> MYnTRW5ITVJ?
D-336MG NHK1eHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnjTWM2OD12MT64OFQzKM7:TR?= Mn;lV2FPT0WU
UACC-62 NWjJZ|duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjKOolUUUN3ME20Nk42PTB3IN88US=> MmT0V2FPT0WU
C-33-A Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m0OGlEPTB;NEWuN|I2PiEQvF2= MVjTRW5ITVJ?
HCC1937 NF3sUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXUSXpzUUN3ME20O{4yQTV6IN88US=> NY\OcppWW0GQR1XS
HDLM-2 MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPMUVJSUUN3ME20O{4zOjh5IN88US=> NIH5O3pUSU6JRWK=
NCI-H727 M4HMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojMTWM2OD12Nz6yOFUyKM7:TR?= MV7TRW5ITVJ?
NY MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTR7LkO5NFgh|ryP Mn;IV2FPT0WU
NCI-H2291 NHnZTpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLtTWM2OD12OT64N|AyKM7:TR?= MnuzV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01281176 Active not recruiting Adult Solid Neoplasm National Cancer Institute (NCI) February 9 2011 Phase 1
NCT01189266 Active not recruiting Anaplastic Astrocytoma|Anaplastic Oligoastrocytoma|Brain Stem Glioma|Childhood Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma|Untreated Childhood Anaplastic Astrocytoma|Untreated Childhood Anaplastic Oligoastrocytoma|Untreated Childhood Brain Stem Glioma|Untreated Childhood Giant Cell Glioblastoma|Untreated Childhood Gliosarcoma National Cancer Institute (NCI) August 9 2010 Phase 1|Phase 2
NCT00703664 Completed Recurrent Mantle Cell Lymphoma|Recurrent Non-Hodgkin Lymphoma National Cancer Institute (NCI) July 9 2008 Phase 2
NCT03198559 Suspended HIV Infections The Peter Doherty Institute for Infection and Immunity|Merck Sharp & Dohme Corp.|The Alfred|University of Melbourne August 8 2017 Phase 1|Phase 2
NCT02538510 Active not recruiting Head and Neck Squamous Cell Carcinoma|Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Recurrent Nasopharynx Carcinoma|Recurrent Salivary Gland Carcinoma|Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary|Stage III Major Salivary Gland Carcinoma|Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage III Nasopharyngeal Carcinoma|Stage IV Nasopharyngeal Carcinoma|Stage IVA Major Salivary Gland Carcinoma|Stage IVA Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVB Major Salivary Gland Carcinoma|Stage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma|Stage IVC Major Salivary Gland Carcinoma|Stage IVC Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma University of Washington|National Cancer Institute (NCI) October 8 2015 Phase 1|Phase 2
NCT01983969 Completed Advanced Cancers|Lymphoma M.D. Anderson Cancer Center November 7 2013 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID