Vorinostat (SAHA)

For research use only.

Catalog No.S1047 Synonyms: MK0683

309 publications

Vorinostat (SAHA) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

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Selleck's Vorinostat (SAHA) has been cited by 309 publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 NVTDTHNrU2mwYYPlJGF{e2G7 MV2xJIg> M1rMb2ROW09? M1zLeIFvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= NFHwdpgyOTl4MES4PS=>
Friend leukemic cell M{XLb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXwWmhDPTBizszN M4Pq[|czKGh? MUXEUXNQ MmK1TWM2OD1yLkm5JO69VQ>? NWLqWGtTOTJzMEm5NVM>
K562 NF74W5NMcW6jc3WgRZN{[Xl? NFnCVHo3KGh? MWfEUXNQ M4O0SGlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> M4G4OFEzPDF7M{iw
HT1080 NF\xTJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPXfmdVPzJiaB?= MWHEUXNQ MUTJR|UxRTJwNDFOwG0> M1K3WVEzOjdyMUe1
H1299 MUXLbY5ie2ViQYPzZZk> NH:xT40zOCCvaX6= NU[2fJlQTE2VTx?= MmT2TY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= M2O1O|E1PTJzNEKy
H1299 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:3NkBp Mn3tSG1UVw>? NIq1bFRKSzVyPUeuNlQh|ryP NVe3d3Z2OTR3MkG0NlI>
HeLa NEe2[25McW6jc3WgRZN{[Xl? NHPCeIw{OCCvaX6= NV7ES5ZFUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? NGHnNWUyPTZyM{m0PS=>
LOX-IMVI NXOxTpYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzOOFghcA>? NUX4[5RYUUN3ME2xMlMh|ryP MXSxOVcyPTR5MB?=
NCI-H226 NUTwUmVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLnOHhGPDhiaB?= Mmn4TWM2OD1{Lk[g{txO NUfMU2RCOTV5MUW0O|A>
RXF-631L NH:0VW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\CNYhDPDhiaB?= NYPtXFByUUN3ME2yJO69VQ>? NETSVXEyPTdzNUS3NC=>
SNB-78 M1rQe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXO0PEBp M3XyemlEPTB;MU[g{txO M{PVW|E2PzF3NEew
St-4 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPpOFghcA>? M13Qc2lEPTB;NT6yJO69VQ>? MUSxOVcyPTR5MB?=
ARP1 MWDGeY5kfGmxbjDBd5NigQ>? NFvoO4IzKM7:TR?= Ml7WOkBp NVnKb4hFUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NI\CSW4yPDd|NEiwOi=>
CEM Ml3ST4lv[XOnIFHzd4F6 MYixJIg> Ml:1SG1UVw>? MkjvTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? M3XrWlE3PDJyME[0
HCT15 NHfJbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\yOFghcA>? NYrVVYZGT0l3ME2wMlgzKM7:TR?= M{DMUVE3PzJ|MkK3
NCI-H23 NFf0fIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUe0PEBp NYCyS49FT0l3ME2wMlkzKM7:TR?= MY[xOlczOzJ{Nx?=
GM15850 MUTLbY5ie2ViQYPzZZk> MX[yMlUh|ryP NWTWSnAzQTZiaB?= NF3nXGVFVVOR M1vNOGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIx6e2mwZTCxOEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M3q1b|E3QTJzM{[3
GM15850 NGDXeYFMcW6jc3WgRZN{[Xl? MVGyMlUh|ryP MVK5OkBp M3;ORmROW09? M1vweGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC1JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NYmxO2xrOTZ7MkGzOlc>
GM15850 MUHLbY5ie2ViQYPzZZk> MWGyMlUh|ryP MmfxPVYhcA>? M3PGZ2ROW09? NX;hWlJ{UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NHiyTXMyPjl{MUO2Oy=>
GM15850 MV7LbY5ie2ViQYPzZZk> NVLLNopDOi53IN88US=> MVK5OkBp NFf2VIJFVVOR MmT5TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NXr0O2R2OTZ7MkGzOlc>
GM15850 M1fKOmtqdmG|ZTDBd5NigQ>? MnrsNk42KM7:TR?= MlLBPVYhcA>? MkLtSG1UVw>? MmLZTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEigZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NWPHcGRSOTZ7MkGzOlc>
GM15850 M2nsNWtqdmG|ZTDBd5NigQ>? NY\j[nZ4Oi53IN88US=> NGLmdXM6PiCq MmnVSG1UVw>? M3rtVGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NX3iWlJTOTZ7MkGzOlc>
U937 NX\XfmJUTnWwY4Tpc44hSXO|YYm= M{HWNFUh|ryP MnTlNlQhcA>? M{X6eGROW09? M1PlV2NmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? NULTcZl6OTdyMES3NVg>
H661 M3PyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGCycJY1QCCq M4nWcmlEPTB;MTFOwG0> M3jKTlE4OTV5MEC5
U937 M3TqbWZ2dmO2aX;uJGF{e2G7 NWfTRWluPSEQvF2= M2r5NlI1KGh? MonLSG1UVw>? NUTIcpdNUW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> MWOxO|Q1Pzd3MB?=
U937 NFi3fFJHfW6ldHnvckBCe3OjeR?= MWCxJO69VQ>? NH3Gc3MzPCCq Ml;0SG1UVw>? NUXFNnlWTW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> NHHPTm4yPzR2N{e1NC=>
RAW264.7 MVrGeY5kfGmxbjDBd5NigQ>? NITUOFYyOCEQvF2= NWLnXnNEOjSq M3\4NpdifGW{ NWrZfG5iUW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCWTl\hcJBp[SCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAxNjd4IN88US=> MVmxO|Q4PzVzOB?=
RAW264.7 MYDGeY5kfGmxbjDBd5NigQ>? NWH4Vnc1OTBizszN M4LNNVI1cA>? M33kOJdifGW{ MlzpTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> Mn3tNVc1Pzd3MUi=
SC9 NGjO[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjqZpQ1QCCq MXnJR|UxRTBwNkC2JO69VQ>? NF;ucpEyPzVyN{KxPS=>
ST14A MlS2SpVv[3Srb36gRZN{[Xl? NHzqT3Q2KG6P MVm3NkBp M4HUdWlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> M3LndlE4PTZ3OUmz
ST14A MU\GeY5kfGmxbjDBd5NigQ>? MYG1JI5O MXi3NkBp NF\rN3VKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= M3vtfVE4PTZ3OUmz
PANC1 M4LmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXSxJO69VQ>? MXvJR|UxRTBwNEWg{txO M3T0dFE4PTh6N{S0
PANC1 NHHibJdHfW6ldHnvckBCe3OjeR?= M2K2fVEh|ryP MVWyOEBp NH\1R|BKdmO{ZXHz[UBqdiCyMkHXRWYyN0OLUEGg[4Vv\SCneIDy[ZN{cW:w NHS5UGkyPzV6OEe0OC=>
PANC1 Moi1SpVv[3Srb36gRZN{[Xl? MWCxJO69VQ>? NIrPZ3AzPCCq M4TLemlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NIXxVG8yPzV6OEe0OC=>
PT45 NVnPcXNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTRizszN NIS1WmsyPzV6OEe0OC=>
ACHN M1r5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PESVIyKGh? MlTwS2k2OD1yLk[1JO69VQ>? NYTGc|l[OTd4NkK2NFY>
PC3 NX7kUWJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljGNlEhcA>? M1TaWGdKPTB;MD63NUDPxE1? MkT6NVc3PjJ4ME[=
A431 NYPCWZo6S3m2b4TvfIlkKEG|c3H5 MYi3NkBp M{HQU2lEPTB;ND6yJO69VQ>? NFvlXmgyPzZ7MUe2Ny=>
Cal27 MWLDfZRwfG:6aXOgRZN{[Xl? MlzrO|IhcA>? M{T6SWlEPTB;Mz6yJO69VQ>? M1GzO|E4PjlzN{[z
CCRF-CEM NU\lV|Z7S3m2b4TvfIlkKEG|c3H5 NHK3[5Y4OiCq MVnJR|UxRTBwODFOwG0> NFv4Wm0yPzZ7MUe2Ny=>
EOL1 NV\tTWVLS3m2b4TvfIlkKEG|c3H5 M4nqeFczKGh? M{HzSmlEPTB;MTFOwG0> MYixO|Y6OTd4Mx?=
Hec-1-A NFv4b5REgXSxdH;4bYMhSXO|YYm= M37JTlczKGh? MYXJR|UxRTFizszN NVnGc251OTd4OUG3OlM>
HeLa NXftN3FTU2mwYYPlJGF{e2G7 MlX4NVAh|ryP MoHwN|AhdWmw NUTPVlhMTE2VTx?= NIHPS|BKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGhFSUNzIIfpeIghUUN3MDDv[kAxNjB{IN88US=> NYPn[|ZiOTd4OUG3OlM>
RKOp21 NFL4T5pEgXSxdH;4bYMhSXO|YYm= NFrGUII4OiCq MnmyTWM2OD1zLke2JO69VQ>? M3TFXFE4PjlzN{[z
Saos2 M3q2O2N6fG:2b4jpZ{BCe3OjeR?= M1rTelczKGh? MYfJR|UxRTJwMzFOwG0> NEnjfnAyPzZ7MUe2Ny=>
SK-OV-3 MmLyR5l1d3SxeHnjJGF{e2G7 MUS3NkBp MmTXTWM2OD1{LkKg{txO MUmxO|Y6OTd4Mx?=
U87MG MYjDfZRwfG:6aXOgRZN{[Xl? NUjhcnpUPzJiaB?= M{TLfWlEPTB;MUGg{txO M2D1Z|E4PjlzN{[z
NUGC3 M2LtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DEVlUh|ryP MnuzNlQhcA>? NWjpVFUzT0l3ME2yMlc6KM7:TR?= NI\sUWMyPzlyNEi0Ny=>
CCD1059SK MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XYT2lEPTB;NEOuOUDPxE1? MoTBNVgzPDd3NUS=
HepG2 NELqfoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXGTWM2OD1yLkCwNFYh|ryP NV:0Xpd[OTh{NEe1OVQ>
HT1080 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfWTWM2OD1yLkCwNlQh|ryP M4fq[FE5OjR5NUW0
SKBR3 NIDOPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHXTWM2OD1yLkig{txO NIXQ[Y8yQDJ2N{W1OC=>
SNB78 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HK[mVEPTB;MU[g{txO NFrYSVEyQDJ2N{W1OC=>
SQ20B MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvqbG5oUUN3ME2zJO69VQ>? NWnHdm9IOTh{NEe1OVQ>
St4 MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHi5XplGSzVyPUWuNkDPxE1? NVznXpY5OTh{NEe1OVQ>
MCF7 MXHGeY5kfGmxbjDBd5NigQ>? MW[xNEDPxE1? NEC2WWY5KGh? NVfyWoxvTE2VTx?= NHvwToNKdmS3Y4Tpc44hd2ZidIXieYxqdiCqeYDldoFk\XS7bHH0bY9v M1\o[|E5OjZ7MkK2
HEK293 NV7hcWlTU2mwYYPlJGF{e2G7 NXfZfItwOSCq NVzKZY1iTE2VTx?= NFi5dGFKdmirYnn0bY9vKG:oIFjERWMyKHerdHigTWM2OCCxZjCwMlA{KM7:TR?= MXOxPFMxQDV4Mx?=
HEK293 NWTXV3Z7U2mwYYPlJGF{e2G7 MnL4NUBp NETaOWNFVVOR NH6wZllKdmirYnn0bY9vKG:oIFjERWM{KHerdHigTWM2OCCxZjCwMlA2PyEQvF2= M4\BR|E5OzB6NU[z
G401 M3vkO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qz[FczKGh? MnPvSG1UVw>? NH3zU4RKSzVyPUGg{txO Mmr2NVg{PzB|N{O=
HeLa NFrJUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUflWYlTPzJiaB?= Mle3SG1UVw>? NYLIN2dXUUN3ME2wMlQ3KM7:TR?= M3SyelE5OzdyM{ez
Human renal epithelial cell M2\v[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG1PGQ4OiCq NUi4Om5FTE2VTx?= NETsd45KSzVyPUG0JO69VQ>? MojaNVg{PzB|N{O=
U937 NVHtbXFFTnWwY4Tpc44hSXO|YYm= M2\OZlUh|ryP MUmyOEBp M{\hUGlv\HWldHnvckBw\iCqaYP0c45mKEh2IHj5dIVz[WOndInsZZRqd25? MonvNVg{QDF{M{i=
U937 NXfRd|B6TnWwY4Tpc44hSXO|YYm= NIDGO4Y2KM7:TR?= MkDQNlQhcA>? NUXIRpVVUW6mdXP0bY9vKG:oIHHsdIhiKHS3YoXsbY4hcHmyZYLhZ4V1gWyjdHnvci=> MUGxPFM5OTJ|OB?=
U937 NYG2UoR7TnWwY4Tpc44hSXO|YYm= MXm1JO69VQ>? MonRNlQhcA>? MWnJcoR2[3Srb36gc4YheDJzIHX4dJJme3Orb36= NIHId|UyQDN6MUKzPC=>
U937 NH\p[mRHfW6ldHnvckBCe3OjeR?= MU[1JO69VQ>? NH;NfI8zPCCq NF\ySm9KdmS3Y4Tpc44hd2ZiYYDvdJRwe2m| NHjWeGYyQDN6MUKzPC=>
U937 MUjGeY5kfGmxbjDBd5NigQ>? MlK1OUDPxE1? MmfMNlQhcA>? MVXJcoR2[3Srb36gc4Yh\3KjboXsc4N6fGmlIHTp[oZmemWwdHnheIlwdg>? NYDEPZNnOTh|OEGyN|g>
U937 NGPXPJZMcW6jc3WgRZN{[Xl? NHrzSFM2KM7:TR?= NXLFNHdGOjRiaB?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJGhFSUNz NY\ReVVMOTh|OEGyN|g>
U937 NUDXRos6U2mwYYPlJGF{e2G7 M13obVUh|ryP MmnTNlQhcA>? Mme3TY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNB?= MkXSNVg{QDF{M{i=
HEK-TE MV3GeY5kfGmxbjDBd5NigQ>? MojZOUDPxE1? M3vIRVZp Mn\5SG1UVw>? MXvJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w Mnu0NVg1OzRzNES=
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Human microvascular epithelial cell NGHwN21EgXSxdH;4bYMhSXO|YYm= MlTNOVAh|ryP NH2weYw4OiCq Mmf4SG1UVw>? MV\JR|UxRTFwMzFOwG0> NVXoWmtROTh2OUS0OlM>
Hup T3 M3\5UWN6fG:2b4jpZ{BCe3OjeR?= MXu1NEDPxE1? NFTJVpg4Omh? Mne5SG1UVw>? NVvBRWV3UUN3ME2wMlgh|ryP M3\JU|E5PDl2NE[z
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HEK293 MVzLbY5ie2ViQYPzZZk> Mom5N{Bp NX7GdpFCUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBJTEGFNjDlfJBz\XO|aX;uJJdqfGhiSVO1NEBw\iByLkCxPUDPxE1? MWqxPFU2QDZ4OR?=
HeLa MXnLbY5ie2ViQYPzZZk> MViyJIg> MVHJcohq[mm2aX;uJI9nKG63Y3zlZZIhUESDQzD3bZRpKEmFNUCgc4YhOC5yOEOg{txO NWXCbZhuOTh3NUi2Olk>
RAW264.7 NGrVblhHfW6ldHnvckBCe3OjeR?= M{O4SlIh|ryP Mkm1N{42KGh? MVrEUXNQ M1\VfmFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDpcoZm[3SnZDD3bZRpKEmFNUCgc4YhOC5zMTFOwG0> NXvwTVlFOTh4NES5Olk>
NB4 MoHROFhp MULEUXNQ M3PIVmlEPTB;MD62JO69VQ>? Ml3qNVg4OjN|NEm=
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HeLa NYPLToFJS3m2b4TvfIlkKEG|c3H5 M{Llc|czKGh? NUe0NmRSS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN NXzD[|dDOjFyOEC2Nlk>
Sf21 NV7NNFlUU2mwYYPlJGF{e2G7 MWCzJIg> NXmydnpRUW6qaXLpeIlwdiCxZjDGcIFoKHSjZ3fl[EBpfW2jbjDy[YNwdWKrbnHueEBJTEGFODDlfJBz\XO|ZXSge4l1cCCLQ{WwJI9nKDFwMjFOwG0> NUHPR2pLOjFyOEC2Nlk>
SKBR3 MYfDfZRwfG:6aXOgRZN{[Xl? NFy2XXM4OiCq NYPOeo1tS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi54IN88US=> M4PTeFIyODhyNkK5
SKOV3 NE[3[YpEgXSxdH;4bYMhSXO|YYm= NGf0SIU4OiCq M1\EV2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z|IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2= NI\xOGkzOTB6ME[yPS=>
COR-L23 NIDHUoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUexNEDPxE1? MYW3NkBp MlKwSG1UVw>? NFGwO2dIUTVyPUGuNUDPxE1? NFfWdXAzOTB6ME[0Oy=>
DU145 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3tR3k4OTBizszN MWm3NkBp NFu5NpBFVVOR NYTtfo9DT0l3ME2xMlA2KM7:TR?= MYiyNVA5ODZ2Nx?=
LoVo MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXixNEDPxE1? NYnIS2pQPzJiaB?= M2W2N2ROW09? MYfHTVUxRTFwNzFOwG0> Ml7INlExQDB4NEe=
MCR5-SV2 M1\3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHnZYdrOTBizszN MUm3NkBp MVnEUXNQ M2TyemdKPTB;Mj6xJO69VQ>? NHW4T5czOTB6ME[0Oy=>
HCT116 NXfadVd{U2mwYYPlJGF{e2G7 MUOzNEDPxE1? NYO4TmdtOzBiaB?= MXTEUXNQ MnLsTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gZYxxcGFvdIXieYxqdiCjY3X0fYxifGmxbh?= M2rXfVIyODhyNkS3
HCT116 MUHLbY5ie2ViQYPzZZk> NU\TUY8yOzBizszN M1XPdVMxKGh? NUDrc4xnTE2VTx?= NVfycpBWUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u NEnD[4gzOTB6ME[0Oy=>
U937 NV3m[YdwU2mwYYPlJGF{e2G7 M3HOeFUh|ryP NUX0OZo1OjRiaB?= MknySG1UVw>? M1jBdWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEt7 MYeyNVI6OjR7Mh?=
U937 NG[xb|BMcW6jc3WgRZN{[Xl? MkTOOUDPxE1? MX[yOEBp NHz5NXBFVVOR MYjJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMOTh? MmfqNlEzQTJ2OUK=
U937 NILaT2RMcW6jc3WgRZN{[Xl? NV\sdlNYPSEQvF2= MYOyOEBp NVryUVc6TE2VTx?= Mm\pTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJJBidi2jY3X0fYxifGWmIHjpd5RwdmViSESgcIV3\Wx? Mlu0NlEzQTJ2OUK=
U937 MVjLbY5ie2ViQYPzZZk> NHP4NWQ2KM7:TR?= MUSxOUBucW5? Mlq2SG1UVw>? NUPsXJdkUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? NWHCUmZ2OjF{OUK0PVI>
A2780 NVzrcItpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf1To06PiCq MYXEUXNQ NVf2WIZWUUN3ME2xMlYzKM7:TR?= MYGyNVY{PDR|MB?=
COLO205 NYTDOW1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUG5OkBp NWLybWttTE2VTx?= MnLpTWM2OD1{LkGyJO69VQ>? M2L6blIyPjN2NEOw
Hep3B NIL1ZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7LOFghcA>? MV3EUXNQ MonvS2k2OD1zLkKxJO69VQ>? M1TXVFIyPzF{MUS2
GM11272 M1LTb2Z2dmO2aX;uJGF{e2G7 MYixNFAhdk1? MnfoO|IhcA>? M3v6VWROW09? NGrjZXRT\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O NF[5OlgzOTh2MEexOi=>
CFBE41o M4LROmtqdmG|ZTDBd5NigQ>? NU\OTY15PSEQvF2= MUDEUXNQ NXjaNld2TG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP NXvzR|luOjF7OES5OVg>
CFBE41o MX7GeY5kfGmxbjDBd5NigQ>? Mn3oNUDPxE1? NEHPWY8zPCCq Mo[ySG1UVw>? NWLMV4kzWmW|dH;yZZRqd25ib3[gR2ZVWiCmZXz0ZWY2ODhibYX0ZY51KHS{YX\mbYNscW6pIITvJINmdGxic4Xy[oFk\SCjczDncJlkd2[xcn3z M2qwUFIyQTh2OUW4
DU145 NVfsXItEU2mwYYPlJGF{e2G7 NUixOIxEOi53IN88US=> NX2yXIZ5OjRiaB?= NVGyWXlyTE2VTx?= M{jTR2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyC3cILl[5Vt[XSrb36gc4YheDJzd3HmNUBxem:2ZXnuJIV5eHKnc4Ppc44> MW[yNlI3ODF4Nh?=
DU145 Mn;mT4lv[XOnIFHzd4F6 NXPxSpZqPSEQvF2= MUSyOEBp NIjPRZFFVVOR M3ezW2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh2IHHj[ZR6dGG2aX;u M2DF[lIzOjZyMU[2
DU145 M3TDemtqdmG|ZTDBd5NigQ>? MmHNOUDPxE1? MW[yOEBp MoPRSG1UVw>? MonYTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? MUGyNlI3ODF4Nh?=
786-0 NVS4PXl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVG2MlIh|ryP Ml7aO|IhcA>? MUTEUXNQ M321XmdKPTB;Mz6yJO69VQ>? MljHNlI1OzV4Nkm=
A498 NGr6b45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrDSXU3NjJizszN M2jwd|czKGh? MYfEUXNQ MmXIS2k2OD1zLk[g{txO NFXVbHozOjR|NU[2PS=>
A549/ATCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TEWlYvOiEQvF2= M4npc|czKGh? NICxRlBFVVOR M{D5VGdKPTB;MT62JO69VQ>? NVfueG9{OjJ2M{W2Olk>
ACHN NHLDRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknCOk4zKM7:TR?= NFWwcZg4OiCq NXm4OYZXTE2VTx?= NGrtVZNIUTVyPUGuN{DPxE1? NIfFU4YzOjR|NU[2PS=>
BT549 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PuXFYvOiEQvF2= NVrr[phJPzJiaB?= NW\lVZJrTE2VTx?= NXXwbmh1T0l3ME2xMlMh|ryP MUGyNlQ{PTZ4OR?=
EKVX M4PpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfDSGI2Pi5{IN88US=> NFHEUY84OiCq Mn3HSG1UVw>? NFjuOGpIUTVyPUGuN{DPxE1? MnX2NlI1OzV4Nkm=
HCT15 NXTWOotpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPBOk4zKM7:TR?= Mn;kO|IhcA>? NWWyRXBzTE2VTx?= NVHFblNnT0l3ME2yMlUh|ryP NGPTd2kzOjR|NU[2PS=>
HOP92 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf0N2VmPi5{IN88US=> M3\HPVczKGh? MlOwSG1UVw>? NX;3W|hvT0l3ME20JO69VQ>? M2jhOVIzPDN3Nk[5
IGROV1 NFjBNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVu2MlIh|ryP NF7QWJc4OiCq NF61bFhFVVOR NYiyN2g6T0l3ME2xMlMh|ryP NIfZdYgzOjR|NU[2PS=>
LOXIMVI MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjXOk4zKM7:TR?= MXq3NkBp MVfEUXNQ NFvQclFIUTVyPUGg{txO MWGyNlQ{PTZ4OR?=
M14 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjWOk4zKM7:TR?= MnXyO|IhcA>? NGH2O5ZFVVOR NHrWfmVIUTVyPUGuN{DPxE1? MoXXNlI1OzV4Nkm=
MALME-3M M1z0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TORlYvOiEQvF2= MkjPO|IhcA>? M3T5cWROW09? MUnHTVUxRTBwM{Kg{txO M4iyXFIzPDN3Nk[5
MCF10A MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jCNlYvOiEQvF2= MoP2OFghcA>? M1H4WWROW09? M1q3T2dKPTB;OT62JO69VQ>? MlXENlI1OzV4Nkm=
MDA-MB-435 NH\teFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fLc|YvOiEQvF2= NVTPNWVkPzJiaB?= MlvsSG1UVw>? MULHTVUxRTBwNTFOwG0> NHjw[IgzOjR|NU[2PS=>
MDA-MB-468 M4nLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXS2MlIh|ryP MofIO|IhcA>? NVrtfJZLTE2VTx?= M4nadmdKPTB;MD62N{DPxE1? MoTnNlI1OzV4Nkm=
MOLT4 NGjlRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzXOk4zKM7:TR?= NYC1PHFVPzJiaB?= MX\EUXNQ M1HDdWdKPTB;MD60JO69VQ>? NWf4bHd7OjJ2M{W2Olk>
NCI-ADR-RES M3[yZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUi2MlIh|ryP MXW3NkBp M1frNGROW09? NVHGVoNiT0l3ME2wMlE3KM7:TR?= NFnmU|IzOjR|NU[2PS=>
NCI-H23 M2fVOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorhOk4zKM7:TR?= MXO3NkBp MnLFSG1UVw>? MYjHTVUxRTFizszN MYqyNlQ{PTZ4OR?=
NCI-H322M MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXUe|Q3NjJizszN M3\zfVczKGh? NV;SfIpQTE2VTx?= M1O0cGdKPTB;MD63PUDPxE1? NEnIeWEzOjR|NU[2PS=>
NCI-H460 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTDcIk3NjJizszN NI\BU5Q4OiCq MmH0SG1UVw>? MnHVS2k2OD1yLke5JO69VQ>? MVeyNlQ{PTZ4OR?=
NCI-H522 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG3UWs3NjJizszN NGHDeFE4OiCq NYOwTVVrTE2VTx?= NHjQXmNIUTVyPUCuOUDPxE1? Ml\UNlI1OzV4Nkm=
OVCAR3 M2XzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELyW4M3NjJizszN NVi4TlB5PzJiaB?= NEPIZ|hFVVOR M1TQTWdKPTB;MT6zJO69VQ>? M3LOZVIzPDN3Nk[5
OVCAR4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fu[VYvOiEQvF2= MYi3NkBp NVe4NW5VTE2VTx?= NGmxTXFIUTVyPUSg{txO M374fFIzPDN3Nk[5
OVCAR5 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7afZM3NjJizszN NF\NVZM4OiCq MUDEUXNQ M17TTmdKPTB;MD63PUDPxE1? MkfONlI1OzV4Nkm=
OVCAR8 M2rrSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVq2MlIh|ryP MXK3NkBp Mk\VSG1UVw>? M{Xw[mdKPTB;MD61JO69VQ>? NIH2RnYzOjR|NU[2PS=>
RXF393 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof1Ok4zKM7:TR?= NGDyRpQ4OiCq MUXEUXNQ NUKyNllwT0l3ME2xMlMh|ryP NWLjO49ZOjJ2M{W2Olk>
SF268 M3rsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;sPI5PPi5{IN88US=> NVezd2dSPzJiaB?= MVjEUXNQ M33h[2dKPTB;MT62JO69VQ>? MnjTNlI1OzV4Nkm=
SF295 NYLYTnVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HOdFYvOiEQvF2= NGPzUY04OiCq M325WGROW09? NEKyeINIUTVyPUGuOkDPxE1? M{DP[|IzPDN3Nk[5
SF539 NGjYW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y3[lYvOiEQvF2= MnnrO|IhcA>? Mkf3SG1UVw>? M{\6XGdKPTB;MjFOwG0> NWHJN3hQOjJ2M{W2Olk>
SK-MEL-2 NU[3eoxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYG2MlIh|ryP MoC4O|IhcA>? NYP4dZIzTE2VTx?= MX7HTVUxRTFwMzFOwG0> MXyyNlQ{PTZ4OR?=
SK-MEL-28 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXm2MlIh|ryP M1TZOVczKGh? MXTEUXNQ M2rDcmdKPTB;MTFOwG0> NInyWYozOjR|NU[2PS=>
SK-MEL-5 NXHNR2tGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnuc2tbPi5{IN88US=> M3zUXFczKGh? NV\BN4lZTE2VTx?= MVTHTVUxRTBwNkOg{txO MV:yNlQ{PTZ4OR?=
SKOV3 M175cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUG2MlIh|ryP MoHDO|IhcA>? MojXSG1UVw>? MYHHTVUxRTFizszN Mm\YNlI1OzV4Nkm=
SN12C NFrFU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LsVFYvOiEQvF2= NV22V4RYPzJiaB?= NFTNSHhFVVOR MUPHTVUxRTJizszN NHLOV4MzOjR|NU[2PS=>
SNB19 NX:1c5RKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHy2dmI3NjJizszN M37YcVczKGh? NXLYRW03TE2VTx?= MV7HTVUxRTBwNkOg{txO NGTzNpUzOjR|NU[2PS=>
SNB75 M{n3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorqOk4zKM7:TR?= NIDxR2M4OiCq MWfEUXNQ M2LWO2dKPTB;MD63PUDPxE1? NIPtXFEzOjR|NU[2PS=>
SR M1PhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2[xfFYvOiEQvF2= MX63NkBp M2DKR2ROW09? NHP3PVdIUTVyPUCuOEDPxE1? NED1NY4zOjR|NU[2PS=>
T47D NFKxeYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYGyOWoyPi5{IN88US=> NXLYUIRDPzJiaB?= NHHZWXFFVVOR NFfWXWhIUTVyPUCuOUDPxE1? M{fCXFIzPDN3Nk[5
TK10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWm2MlIh|ryP MV23NkBp NX3vcpZwTE2VTx?= NXToToxCT0l3ME2wMlY{KM7:TR?= NVnKPXk3OjJ2M{W2Olk>
UACC257 NEfGXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjKe5Y3NjJizszN NFzEZWs4OiCq M1[xWmROW09? MWnHTVUxRTBwNTFOwG0> M3\4NlIzPDN3Nk[5
UACC62 MkLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYC2MlIh|ryP MkLoO|IhcA>? MVXEUXNQ NYe3bmVkT0l3ME2wMlQh|ryP NGHNWXozOjR|NU[2PS=>
UO31 NFzRfI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jm[FYvOiEQvF2= NEDTNo84OiCq Mn6xSG1UVw>? MWLHTVUxRTBwNTFOwG0> NGPUfGozOjR|NU[2PS=>
Hep3B NGLoSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYm0PEBp NUXwWIVFTE2VTx?= Mk\hS2k2OD1yLk[5JO69VQ>? M3\L[VIzPDN7OE[z
BE(2)-C NID2SVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO3NkBp MoHnSG1UVw>? NYTj[pc2UUN5ME2yJO69VQ>? M37QNlIzQTN{M{G2
Bel7402 NXLOS5dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfWO|IhcA>? MUTEUXNQ NVO1WYJ2T0l7ME2xO{DPxE1? Mke0NlMxPjF|N{[=
Bel7404 MnT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnKwO|IhcA>? MYHEUXNQ MlSyS2k6OD1zODFOwG0> MVSyN|A3OTN5Nh?=
BGC823 NG\uSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;VXIw4OiCq MnWySG1UVw>? MnW4S2k6OD15LkWg{txO MlHuNlMxPjF|N{[=
MGC803 M1LEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLIO|IhcA>? MVnEUXNQ MXXHTVkxRTFyLkig{txO NGfzN4kzOzB4MUO3Oi=>
SGC7901 M{HXdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nrT|czKGh? MkLZSG1UVw>? NUnzPWp3T0l7ME25MlQh|ryP MlvNNlMxPjF|N{[=
SKHEP1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\hdlczKGh? MYHEUXNQ NGH2WFlIUTlyPUG3JO69VQ>? M1nNN|I{ODZzM{e2
SMMC7721 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\3O|IhcA>? MljxSG1UVw>? MkHoS2k6OD1{MDFOwG0> MW[yN|A3OTN5Nh?=
NUGC3 NUfmfZNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH0NVAh|ryP Ml;uS2k:Oi57NDFOwG0> M{noNVI{OTZ|M{Oy
A2780 CisR NVrW[oJ7U2mwYYPlJGF{e2G7 M4HEVFE5KGh? NEfWbFdKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP NF7afHYzOzJ3Mk[wNy=>
CAL27 sens Mlm4T4lv[XOnIFHzd4F6 MWWxPEBp MX3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO M2LuSVI{OjV{NkCz
CAL27 CisR M3\TWmtqdmG|ZTDBd5NigQ>? M3TyXlE5KGh? NHHR[IRKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MlPlNlMzPTJ4MEO=
KYSE-510 CisR M3[yRWtqdmG|ZTDBd5NigQ>? NVvmfJVGOThiaB?= MYrJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO NX6wV2FROjN{NUK2NFM>
KYSE-510 sens M{CycGtqdmG|ZTDBd5NigQ>? MnzSNVghcA>? NGXpSIFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? NXnkb2ZoOjN{NUK2NFM>
MDA-MB-231 sens M3T2b2tqdmG|ZTDBd5NigQ>? MUGxPEBp NWqwbmFoUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlYyKM7:TR?= M4PMdlI{OjV{NkCz
MDA-MB-231 CisR NYHNSZhbU2mwYYPlJGF{e2G7 MXWxPEBp MWnJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO MV:yN|I2OjZyMx?=
ES2 NEfa[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PDVVQ5KGh? MYLEUXNQ MmH6TWM2OD1zMj63JO69VQ>? MkTmNlM1QTN2NEm=
MDA-MB-231 MVXLbY5ie2ViQYPzZZk> MXqxNEDPxE1? MVOzNEBucW5? Mn\vSG1UVw>? MlzvTY5pcWKrdHnvckBw\iCKRFHDNoE> MXuyN|Q6OzR2OR?=
MDA-MB-231 MmL0T4lv[XOnIFHzd4F6 M13DXFEh|ryP NIP6bIczPCCq NETpUGRFVVOR NVXsb2tCUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NXLDXVFDOjN2OUO0OFk>
HS68 M2TvRWN6fG:2b4jpZ{BCe3OjeR?= NXvVRoVIOTBizszN MoDXO|IhcA>? MXPEUXNQ NHv2VlVKSzVyPUSuOkDPxE1? NUfOR3lHOjN3N{C1OFI>
MEF M2rmeWN6fG:2b4jpZ{BCe3OjeR?= Ml7TNVAh|ryP MmrNO|IhcA>? M3jjdGROW09? M{P5O2lEPTB;ND60JO69VQ>? MWWyN|U4ODV2Mh?=
BGC823 NYHZN2RwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K5dmROW09? MYDHTVUxRTNwMEmg{txO M3TYPFI{PjBzN{C2
High5 M{PCTGtqdmG|ZTDBd5NigQ>? MVyyOEBp MX\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? NEfveXozOzZyMkWyNy=>
High5 MmfZT4lv[XOnIFHzd4F6 NUmy[pk2OjRiaB?= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>? NXTQNYN1OjN4MEK1NlM>
High5 M{DJZmtqdmG|ZTDBd5NigQ>? NU\y[ZRwOjRiaB?= M1PvN2lvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Mhf2m2aDDJR|UxKG:oIECuNVch|ryP MnzkNlM3ODJ3MkO=
A549 NVzoVGZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj0SFVFVVOR MmH3TWM2OD1zLkC3PUDPxE1? MnHLNlM3PDR{MUC=
HCT116 M{flcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHEUXNQ MYLJR|UxRTBwN{W3JO69VQ>? NGX1WYgzOzZ2NEKxNC=>
K562 NEPKZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3EUXNQ M4HhcWlEPTB;MD62OFUh|ryP MXOyN|Y1PDJzMB?=
GBC-SD NYXq[5VFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3flN|Uh|ryP NHPnV2Y4OiCq MYHEUXNQ M{ixV2lEPTB;MUSuPEDPxE1? NXj6NmxKOjN5MEeyOlA>
HGC27 MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVm1JO69VQ>? NF;hOow4OiCq NHrZVlRFVVOR NI\ydoRKSzVyPUWuOEDPxE1? NXTqeXVpOjN5MEeyOlA>
HL60 MVTLbY5ie2ViQYPzZZk> MXO1JO69VQ>? M2T4VFI1KGh? M2X1ZWROW09? MWLJcohq[mm2aX;uJI9nKEiGQVO= NY\lc|RnOjN5MEeyOlA>
Vero NWPqV|cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nFOFczKGh? NIr3WWFFVVOR MmftTWM2OD1yLkmg{txO NUfFfW5[OjN5OE[0OVI>
NCI60 NGLac|lEgXSxdH;4bYMhSXO|YYm= NIi1OmU1QCCq MYnEUXNQ NYnpOZJtT0l;MD61N{DPxE1? MojsNlQxOTV|Mke=
SW620 M1zSd2N6fG:2b4jpZ{BCe3OjeR?= M4jLclQ5KGh? NFHQTmxFVVOR NH\vS3VIUT1yLkW0JO69VQ>? MYWyOFAyPTN{Nx?=
U251 NGG5ZopEgXSxdH;4bYMhSXO|YYm= MXq0PEBp M1T4VGROW09? Mk\4S2k:OS53MzFOwG0> NHj6[44zPDBzNUOyOy=>
KM12 NV3TPY9qS3m2b4TvfIlkKEG|c3H5 MWC0PEBp NYPTS5RTTE2VTx?= NV2xb|A{T0l;MT64PEDPxE1? MnLHNlQxOTV|Mke=
Hs578T MWHDfZRwfG:6aXOgRZN{[Xl? NV;uVZZYPDhiaB?= NXnkVWxrTE2VTx?= MlfKS2k:PC56MzFOwG0> M3PXUVI1ODF3M{K3
MDA-MB-231 NGnmVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[x[5c1QCCq MlH4TWM2OD1yLkG2JO69VQ>? Mn\jNlQxQTVyMU[=
MCF7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\5VWg1QCCq M13iS2dKRTBwNEWg{txO M2m2fFI1OTF7NUW1
MDA-MB-435 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITabnU1QCCq M3f5c2dKRTBwOEig{txO NHnCPHMzPDFzOUW1OS=>
AsPC1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L1d|MxKM7:TR?= MWG0PEBp NFvD[IZFVVOR M1zw[WlEPTB;Mz62OkDPxE1? Ml3VNlQyQDV|N{i=
Jurkat E6.1 M{fsV2tqdmG|ZTDBd5NigQ>? M3jR[VIhcA>? NI[4cVNFVVOR MmHOTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? NEfKTXQzPDJ4MUi2Ni=>
KG1 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWe0PEBp MV3JR|UxRTFwMUWg{txO MlL6NlQ2OjVyMEO=
HEL Mn7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rVdVQ5KGh? M4C0emROW09? NEXMZYxKSzVyPUCuOFkh|ryP M3XSNFI1Pjl2MEW1
HSC3 NHHTW|hEgXSxdH;4bYMhSXO|YYm= NWTDcYxDOTJiaB?= MYXEUXNQ NEWwOm1KSzVyPUCuO|Eh|ryP NY\WXZViOjR5Nk[1OlA>
HT-29 M3;4dWN6fG:2b4jpZ{BCe3OjeR?= MV2xNkBp Mo\LSG1UVw>? M{DUbGlEPTB;MD63NkDPxE1? M3TROFI1PzZ4NU[w
KB MlXDR5l1d3SxeHnjJGF{e2G7 MV2xNkBp MkTJSG1UVw>? M1f3UGlEPTB;MD63OUDPxE1? NWHjW2NTOjR5Nk[1OlA>
H460 MVLDfZRwfG:6aXOgRZN{[Xl? M2LxTVEzKGh? NVXwOZI3TE2VTx?= MWfJR|UxRTBwOEKg{txO NWLNVWd7OjR5Nk[1OlA>
MONE1 NUnyfYpoS3m2b4TvfIlkKEG|c3H5 M1;ZZlEzKGh? M3;LTmROW09? NWrnSpRyUUN3ME2xMlE5KM7:TR?= MVGyOFc3PjV4MB?=
MKN45 NFj1NJJEgXSxdH;4bYMhSXO|YYm= MVWxNkBp M13YeWROW09? MWLJR|UxRTFwMkWg{txO NYjOdWFrOjR5Nk[1OlA>
TSGH NVfPcWo6S3m2b4TvfIlkKEG|c3H5 NUflUVM5OTJiaB?= M3fhOmROW09? MoPBTWM2OD1{LkC5JO69VQ>? NYDScGRuOjR5Nk[1OlA>
HL60 M1n2TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILsXmY4OiCq MlT2SG1UVw>? MWfHTVUxRTBwOUOg{txO NYrTclJVOjR7MEC1NFA>
HEK293 NF33[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vPfFczKGh? MX;EUXNQ NXfRcVQxT0l3ME2xN{DPxE1? MnnXNlQ6ODB3MEC=
Jurkat M3XiOWN6fG:2b4jpZ{BCe3OjeR?= MmjUNVAxKM7:TR?= M2TMcFczKGh? MXzHTVUxRTBwOTFOwG0> NGLZ[44zPDlyMEe0Ny=>
GM15850 NVrY[3JrU2mwYYPlJGF{e2G7 NYDNWIx6Oi53IN88US=> MYC5OkBp Ml21SG1UVw>? NH3oNXFld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJOyCueYPpcoUhOTRiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MX[xOlkzOTN4Nx?=
GM15850 MUPLbY5ie2ViQYPzZZk> NF7MSpAzNjVizszN M3PHPVk3KGh? NUDMbm5LTE2VTx?= MmTB[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NFu4NowyPjl{MUO2Oy=>
GM15850 NWDGbFRzU2mwYYPlJGF{e2G7 NHrvZ5czNjVizszN MlPPPVYhcA>? NV\DTopWTE2VTx?= NYS2NpJD\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m M2O5b|E3QTJzM{[3
GM15850 MnLJT4lv[XOnIFHzd4F6 MomwNk42KM7:TR?= MVq5OkBp NGPoOlNFVVOR NUXOOJZX\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDliYXPleJlt[XSrb36gc4YhTliQIHflcoU> NUTIW2VTOTZ7MkGzOlc>
GM15850 M2DHNmtqdmG|ZTDBd5NigQ>? NGPtVmczNjVizszN NIKxbG86PiCq NYrIO25rTE2VTx?= MoK3[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NEK0blgyPjl{MUO2Oy=>
GM15850 Mn6xT4lv[XOnIFHzd4F6 MmrnNk42KM7:TR?= M2jJbFk3KGh? M4LWdmROW09? M4nScoRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyPiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NVrTSXB2OTZ7MkGzOlc>
GM15850 MlPHSpVv[3Srb36gRZN{[Xl? M2LBcFUh|ryP NWC5fXd5OTJiaB?= NYDGRVdWTE2VTx?= Ml\sbIF{KG6xIHXm[oVkfCCxbjDGXG4hdVKQQTDlfJBz\XO|aX;u MYmxOlkzOTN4Nx?=
U937 MmLJT4lv[XOnIFHzd4F6 NGLjTG02KM7:TR?= M{HKPVI1KGh? NVrNTIJNTE2VTx?= NVKz[HJtcGG|IH7vJIVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u M1;LXVE4PDR5N{Ww
U937 NWC5Z29{U2mwYYPlJGF{e2G7 MXqxJO69VQ>? M1rYXVI1KGh? MnL2SG1UVw>? MkT3bIF{KG6xIHXm[oVkfCCxbjDhcJBp[SC2dXL1cIlvKGGlZYT5cIF1cW:w NGD2TYMyPzR2N{e1NC=>
PANC1 M1fDV2Z2dmO2aX;uJGF{e2G7 NH7XZVcyKM7:TR?= MmXhNlQhcA>? Mk[5[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= M{joUFE4PTh6N{S0
PANC1 M1P0e2Z2dmO2aX;uJGF{e2G7 NXriWXVbOSEQvF2= MkPSOFghKGh? M2\UPYRw\XNibn;0JIlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u M3Xyb|E4PTh6N{S0
Caco-2 M1H4UmZ2dmO2aX;uJGF{e2G7 NHm5O2U2KM7:TR?= MojYNlQhcA>? M{[1VGROW09? Ml73[I9meyCwb4SgbY5lfWOnIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v Mof3NlAyPDN6NEC=
SCC4 NWLVeG8xTnWwY4Tpc44hSXO|YYm= MVOxJO69VQ>? NUjGb5c4OTBibXnu M2rRVWROW09? MYToZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? MYKyNFQ2OjJ{NR?=
A549 M{nHcWZ2dmO2aX;uJGF{e2G7 NWDafpVPPSEQvF2= MonKN{Bp M2Ljc2ROW09? Mk\G[I9meyCwb4SgbY5lfWOnIHH1eI9xcGGpeTDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> NYnPNnc6OjB6NUWyNFg>
HCT116 NHLxSGFMcW6jc3WgRZN{[Xl? M1fYR|AvOyEQvF2= NIn6RpQ{OCCq NFnJfmRFVVOR MXPkc4V{KG6xdDDpcohq[mm2IFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= NHTMUW4zOTB6ME[0Oy=>
HepG2 M33UTmZ2dmO2aX;uJGF{e2G7 M4jYRVExKM7:TR?= NXnDUpJtOjRiaB?= M{XTWWROW09? M1\XUoRw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhcHmyZYLhZ4V1gWyjdHnvckBw\iCyNUO= NHvZUoEzOTV2OEW4Ni=>
GM11272 MXfGeY5kfGmxbjDBd5NigQ>? M2TOW|AvOSEQvF2= NEHpNYs4OiCq M2G2NGROW09? NV;ZOGFy\G:nczDuc5QhemWjY4TpeoF1\SCPZVPwNkBufXSjboSg[ZhxemW|c3nvci=> NVTt[lNUOjF6NEC3NVY>
MDA-MB-231 M3e3WWtqdmG|ZTDBd5NigQ>? NInE[YwyOCEQvF2= MoTMOUBucW5? NULXTFNnTE2VTx?= NVf2TFQ5\G:nczDuc5QhcW6qaXLpeEBJTEGFMnG= NFvLcYgzOzR7M{S0PS=>
MDA-MB-231 NYmxWYlKU2mwYYPlJGF{e2G7 M4LVelEh|ryP Ml;wNlQhcA>? MnPCSG1UVw>? NX;jdmRp\G:nczDuc5QhcW6qaXLpeEBJTEGFNjDhd5Nme3OnZDDhd{Bi[2W2eXzheIlwdiCuZY\lcJMhd2ZidIXieYxqdg>? MkG1NlM1QTN2NEm=
K562 NGrv[VlMcW6jc3WgRZN{[Xl? NYnIZmdW\G:nczDuc5QhcW6qaXLpeEBJTEGF M3zObFI{PTlzMUGx
Jurkat M2OxUGN6fG:2b4jpZ{BCe3OjeR?= MYKyNEDPxE1? NGH2R5M4OiCq M4jXN2ROW09? NYPzUIk6dm9iY4n0c5RwgGmlaYT5JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9v NFHhTVYzPDNyNEO0PC=>
HCT116 M2m1TGFxd3C2b4Ppd{BCe3OjeR?= NIq2TIo{KM7:TR?= M1vSRVI1KGh? MU\EUXNQ NE\MOY9ld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIC1N{Bxem:2ZXnuJIxmfmWu M{D0VFI1PzZ4NU[w
KASUMI-1 NFziZWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTGNnZLUUN3ME25PU4yPyCwTR?= M1PUdnNCVkeHUh?=
KARPAS-45 M{f1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfIbYd5UUN3ME2xO|MvQDlibl2= Ml3GV2FPT0WU
BHT-101 M{C5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mor3TWM2OD1{NESuNVghdk1? NF71OItUSU6JRWK=
H9 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr5NFE{UUN3ME2yOVUvODRibl2= MoTlV2FPT0WU
PA-1 Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nuOWlEPTB;Mki2MlI3KG6P NYTYOodtW0GQR1XS
NEC8 M2TtVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3PT|E5UUN3ME2yPFkvOzhibl2= M33QcHNCVkeHUh?=
MHH-PREB-1 NUXNR3BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P6VWlEPTB;Mkm0MlU{KG6P NHTTWW9USU6JRWK=
NB7 M3:2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrSN5R3UUN3ME2zOFUvPzRibl2= MVHTRW5ITVJ?
A3-KAW M3voNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHZeGpKSzVyPUSwNE42QSCwTR?= NGG1ZY1USU6JRWK=
NB69 M3i5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTRzMT63NUBvVQ>? MWrTRW5ITVJ?
EoL-1-cell MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTR3NEK1JI5O M3\1VnNCVkeHUh?=
CHP-212 NWXhdXNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfKTWM2OD12NUeuOVMhdk1? NVT5bWRRW0GQR1XS
C2BBe1 NGD2NWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GzVGlEPTB;NEeyMlE6KG6P MVnTRW5ITVJ?
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BE-13 NI\mdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjvWpBKSzVyPUWyOk46PiCwTR?= M4XXZXNCVkeHUh?=
CTB-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHX0[4dKSzVyPUWzO{46OiCwTR?= MWPTRW5ITVJ?
HD-MY-Z NVu2XXZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\CTWM2OD13M{iuNVMhdk1? NV21UZJ4W0GQR1XS
NKM-1 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vBVmlEPTB;NUS0MlI4KG6P MXzTRW5ITVJ?
NCI-H720 NUHSRmh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLUTWM2OD13NkCuNVghdk1? MV7TRW5ITVJ?
KY821 NUCwOXFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWiyOIdMUUN3ME21OlMvOjVibl2= NGPVOnlUSU6JRWK=
OVCAR-5 M3[wRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfYbHV{UUN3ME21O|YvOTFibl2= MlHFV2FPT0WU
CTV-1 NF;pepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTV6MT61OkBvVQ>? NHPmc2NUSU6JRWK=
P12-ICHIKAWA NGDiVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHXTWM2OD13OU[uOVEhdk1? NF;D[3BUSU6JRWK=
DB NFfLXlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3lZWhKSzVyPUW5PE42PyCwTR?= NVfEbZVqW0GQR1XS
CHL-1 M2nGOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fvOWlEPTB;NkSyMlA5KG6P M33KSXNCVkeHUh?=
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MV-4-11 MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTZ3OT6xJI5O MkS0V2FPT0WU
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COLO-320-HSR MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MomzTWM2OD1zLki4NVk4KM7:TR?= MUHTRW5ITVJ?
HN NEK1bnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIOycY1KSzVyPUGuPFg4OjVizszN M3LUb3NCVkeHUh?=
HT MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjFU|M5UUN3ME2xMlg5QTR5IN88US=> M2XVVnNCVkeHUh?=
LoVo M{izW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwOEm4NUDPxE1? MVHTRW5ITVJ?
CGTH-W-1 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHhdYVQUUN3ME2xMlg6QTR4IN88US=> MlO2V2FPT0WU
NB6 MkfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\VTWM2OD1zLkmxNlk5KM7:TR?= MWTTRW5ITVJ?
EW-22 NIPtPVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3xNYdKSzVyPUGuPVI5QDdizszN NH72Z2FUSU6JRWK=
ES6 Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jnZWlEPTB;MT65N|Y{OSEQvF2= MkTWV2FPT0WU
SCC-15 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3KbJVKSzVyPUGuPVM5OTlizszN MnHkV2FPT0WU
HL-60 M1H4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnhTWM2OD1zLkmzPVAzKM7:TR?= NI\EWo5USU6JRWK=
human HOP-92 NHzV[2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTTWpNKSzVyPUGuPVQxPjVizszN NX3RT4djW0GQR1XS
SW626 M1fK[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFwOUS4PVkh|ryP M4Hp[3NCVkeHUh?=
HEC-1 NYThWYtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwOUWzOkDPxE1? NX7RSmt2W0GQR1XS
LB2241-RCC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q2eGlEPTB;MT65PFI{OSEQvF2= NG\lTYlUSU6JRWK=
Ramos-2G6-4C10 M4juOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwOUm0PVMh|ryP M3vFbnNCVkeHUh?=
A101D NVLreZNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwMkCzNFMh|ryP Mk\LV2FPT0WU
NCI-H446 M2HyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nx[WlEPTB;Mj6wOFU6QSEQvF2= MkjkV2FPT0WU
SBC-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3Se5NlUUN3ME2yMlA3OTR5IN88US=> MXjTRW5ITVJ?
HOS NUi4bZVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLJTWM2OD1{LkC3OlU{KM7:TR?= Mk\pV2FPT0WU
K5 M3\mTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW5TWM2OD1{LkC3PFEyKM7:TR?= MlKwV2FPT0WU
HLE M4nFRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvKTWM2OD1{LkC4OVI6KM7:TR?= M1fZV3NCVkeHUh?=
HSC-2 NXnT[ZZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr2W2ZKSzVyPUKuNVI5QThizszN MnfKV2FPT0WU
LCLC-97TM1 M4DHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJwMUS1PFMh|ryP MULTRW5ITVJ?
DMS-273 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrFToxKSzVyPUKuNVQ5OzdizszN M3PZeXNCVkeHUh?=
TE-8 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJwMUW3OlUh|ryP NYewPIo2W0GQR1XS
DSH1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHiTWM2OD1{LkG2N|k5KM7:TR?= NV\mfYZNW0GQR1XS
CAL-51 MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPSTWM2OD1{LkG2Olk6KM7:TR?= MnrSV2FPT0WU
IST-SL1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJwMU[4OFQh|ryP NX;uOoI6W0GQR1XS
GCT M173fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m0emlEPTB;Mj6xO|c4KM7:TR?= MX3TRW5ITVJ?
SW948 MmjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXsTo9KSzVyPUKuNVg1PTZizszN MW\TRW5ITVJ?
NOMO-1 MkjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwMUmzNVch|ryP M2rEenNCVkeHUh?=
C8166 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrjfodKSzVyPUKuNlE{OzRizszN MlrwV2FPT0WU
OC-314 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJwMkOyOVkh|ryP NVqwdXJsW0GQR1XS
CAL-39 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3zNVhKSzVyPUKuNlM3OjZizszN NX;4TIt5W0GQR1XS
MDA-MB-453 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXEPFhKSzVyPUKuNlQzPzVizszN NGfv[YxUSU6JRWK=
A673 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUKyUXlJUUN3ME2yMlI2QDZ{IN88US=> MV3TRW5ITVJ?
HTC-C3 M4iwN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\QW5JKSzVyPUKuNlY5PSEQvF2= NWjSXIRoW0GQR1XS
NCI-H1666 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKwOHhkUUN3ME2yMlI5OTFzIN88US=> M4CzWHNCVkeHUh?=
PSN1 M3\PVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHxe|lKSzVyPUKuNlg6OTNizszN NUnOe5A3W0GQR1XS
GI-1 NYnFXmMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO2TWM2OD1{LkOwOVQ{KM7:TR?= M4TuOHNCVkeHUh?=
HuH-7 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDxTWM2OD1{LkOwOlM4KM7:TR?= MVTTRW5ITVJ?
JAR MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJwM{G5PFch|ryP NF\kPINUSU6JRWK=
5637 M3fXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLmTWM2OD1{LkOyNVI6KM7:TR?= MlO0V2FPT0WU
GB-1 NX7BS5RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO0TWM2OD1{LkOyN|M2KM7:TR?= MkPLV2FPT0WU
KP-N-YS NWrrdGFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTJwM{K2NVUh|ryP MVXTRW5ITVJ?
OAW-42 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJwM{O0NVYh|ryP M4rmZnNCVkeHUh?=
8-MG-BA NHzaWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTmR5FKSzVyPUKuN|M6ODZizszN Mn:3V2FPT0WU
RH-18 NYTBbWNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;CeZhjUUN3ME2yMlM2ODJ{IN88US=> M1XxZXNCVkeHUh?=
NCI-H1155 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLqNHFKSzVyPUKuN|Y4OjVizszN NFz5UWJUSU6JRWK=
NB17 NG[yVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLrTWM2OD1{LkO4NlQ{KM7:TR?= NFHCXWNUSU6JRWK=
NCI-H1437 NGX3fJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjxT29KSzVyPUKuOFE5PzNizszN M1HHTXNCVkeHUh?=
SN12C M2nHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmxTWM2OD1{LkSzNlE1KM7:TR?= MnvkV2FPT0WU
HSC-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXIcXU1UUN3ME2yMlQ1PTB7IN88US=> MojZV2FPT0WU
GAMG Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmwTWM2OD1{LkS0OVYyKM7:TR?= M1jmXnNCVkeHUh?=
HT-1080 NV3nUXlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHsR4FXUUN3ME2yMlQ1QDZ2IN88US=> MUXTRW5ITVJ?
A549 NFnhWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy0XJRXUUN3ME2yMlQ1QDl|IN88US=> M4HBZXNCVkeHUh?=
KNS-62 M1PEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwNEWwOlEh|ryP M3fZO3NCVkeHUh?=
YKG-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\6OWRKSzVyPUKuOFU1OzdizszN MkTqV2FPT0WU
LU-134-A MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPVWJFKSzVyPUKuOFcxODhizszN NXz1bIhvW0GQR1XS
FADU NHKxNIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJwNEexOlIh|ryP MYTTRW5ITVJ?
TGBC11TKB MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn3TWM2OD1{LkS3NVc4KM7:TR?= MWPTRW5ITVJ?
HT-3 NXLadmxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwNEm1N|Uh|ryP NX\Mb2Z5W0GQR1XS
NCI-H2170 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi2PJpHUUN3ME2yMlUxPTR7IN88US=> M4O1W3NCVkeHUh?=
Mo-T NYHWfohjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknLTWM2OD1{LkWwPVI4KM7:TR?= MYfTRW5ITVJ?
CCRF-CEM NH3qSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDTWM2OD1{LkWzNFQ{KM7:TR?= MofjV2FPT0WU
KU-19-19 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7LPGtGUUN3ME2yMlU{PTF|IN88US=> NHfKXlVUSU6JRWK=
NCI-H1048 M2PPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jwV2lEPTB;Mj61OVAzPSEQvF2= NFrpelZUSU6JRWK=
KOSC-2 M2nnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnWTWM2OD1{LkW2NFc3KM7:TR?= NWDrTZpRW0GQR1XS
A431 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PyXGlEPTB;Mj61OlM{PSEQvF2= NIrMb5RUSU6JRWK=
COR-L23 MkDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny4TWM2OD1{LkW4OVY3KM7:TR?= Mm\FV2FPT0WU
MKN28 NInX[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\DU2lEPTB;Mj61PVA{PyEQvF2= M1naenNCVkeHUh?=
22RV1 NF7vPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJwNUmyO|Qh|ryP M3f5SnNCVkeHUh?=
ABC-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[3RmlEPTB;Mj62NFQ3KM7:TR?= NUTVfYtjW0GQR1XS
NCI-H2126 NEfqNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TyXGlEPTB;Mj62NFk5PCEQvF2= MoftV2FPT0WU
DoTc2-4510 M3vHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPLSnliUUN3ME2yMlYzOTh3IN88US=> M3zORnNCVkeHUh?=
SCC-4 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n6dmlEPTB;Mj62N|AyOiEQvF2= NXLwOlh4W0GQR1XS
NCI-H661 MnPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqwTWM2OD1{Lk[0NFg2KM7:TR?= MXzTRW5ITVJ?
RPMI-2650 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDoTWM2OD1{Lk[0NVQ{KM7:TR?= NUnHPGxmW0GQR1XS
NCI-H510A NVzOZ21nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTJwNkS0NlYh|ryP M3u0WHNCVkeHUh?=
BPH-1 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknMTWM2OD1{Lk[1PFUh|ryP NG\mSoVUSU6JRWK=
M14 M4nIN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGy[INKSzVyPUKuOlY6QTNizszN NH7nV5ZUSU6JRWK=
G-402 MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTJwN{C0OVEh|ryP NGnTWZZUSU6JRWK=
AsPC-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PCRWlEPTB;Mj63NVE4KM7:TR?= MYTTRW5ITVJ?
NB12 NVLl[og5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvWTWM2OD1{LkexO|Eh|ryP NFfwWppUSU6JRWK=
SK-HEP-1 M33uS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{CzSWlEPTB;Mj63OFM6OSEQvF2= MnLOV2FPT0WU
U-266 NF7SWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn74TWM2OD1{Lke3NVIyKM7:TR?= MVvTRW5ITVJ?
AM-38 NXfZbXY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWr2T5V5UUN3ME2yMlc4OzV3IN88US=> NYXzSIxLW0GQR1XS
PC-14 M{Dlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4flcmlEPTB;Mj64NFUyKM7:TR?= NEWwXlZUSU6JRWK=
EGI-1 M{j1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu1TWM2OD1{LkixO|Q{KM7:TR?= MXXTRW5ITVJ?
LS-411N MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvETYc4UUN3ME2yMlgzOzNizszN MXrTRW5ITVJ?
BFTC-905 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzsco5EUUN3ME2yMlg2PTJ|IN88US=> NV3rclFNW0GQR1XS
CaR-1 M1HFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJwOE[g{txO MWXTRW5ITVJ?
NCI-H292 NFKzPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwOE[1PVYh|ryP MmLXV2FPT0WU
8305C MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LveWlEPTB;Mj64OlY1PSEQvF2= NHfXcIFUSU6JRWK=
SNU-449 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DjOmlEPTB;Mj64PVE5OiEQvF2= NWDqVIQ2W0GQR1XS
LCLC-103H NGfSV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLISWh[UUN3ME2yMlkxPDN6IN88US=> MkjRV2FPT0WU
SW1573 NHv0WoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfFTWM2OD1{Lkm2NFgzKM7:TR?= NGj3NlFUSU6JRWK=
MLMA NFvSOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwOU[3NVch|ryP NELPVldUSU6JRWK=
NCI-H1355 M3fib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXCdW1KSzVyPUOuNFA4QTZizszN NVLhellDW0GQR1XS
RMG-I M2eyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3nUYRSUUN3ME2zMlAzPTl{IN88US=> NH;jS3BUSU6JRWK=
BB65-RCC M{jHeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNwMEOzNVQh|ryP Mo\WV2FPT0WU
PC-3 NHKxW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofHTWM2OD1|LkCzPFc1KM7:TR?= MnG2V2FPT0WU
SF268 NHThZpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNwMES1NlMh|ryP MWTTRW5ITVJ?
NCI-H810 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH25dFNKSzVyPUOuNFQ5OjNizszN Ml7sV2FPT0WU
MEG-01 M1P5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7lSI1KSzVyPUOuNFYyPjRizszN M2XHUXNCVkeHUh?=
SW13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jaNGlEPTB;Mz6wO|g1PyEQvF2= MYTTRW5ITVJ?
RH-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLQfI5jUUN3ME2zMlExOjd6IN88US=> MXzTRW5ITVJ?
GT3TKB NGH4NpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfpU5lQUUN3ME2zMlEyOjh|IN88US=> MoXnV2FPT0WU
TK10 MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fhUGlEPTB;Mz6xN|czPCEQvF2= M3u2NXNCVkeHUh?=
T-24 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTNwMUWwO{DPxE1? MVnTRW5ITVJ?
A498 MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLFTWM2OD1|LkKwPFcyKM7:TR?= NF32NXNUSU6JRWK=
GR-ST MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TZfmlEPTB;Mz6yNlE{QSEQvF2= MlOyV2FPT0WU
LB2518-MEL M3XtOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\nS2lEPTB;Mz6yNlM6QCEQvF2= MWHTRW5ITVJ?
T47D NIrWS|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNwMkO2Nlch|ryP NG\FVpNUSU6JRWK=
NCI-H1651 M1v6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrDTWM2OD1|LkK0OlQ1KM7:TR?= NGX3TGZUSU6JRWK=
EC-GI-10 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTXN3duUUN3ME2zMlI3OTV|IN88US=> M3;rcnNCVkeHUh?=
HT-29 NELLVnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\yXpBvUUN3ME2zMlI3PjF2IN88US=> MWHTRW5ITVJ?
GI-ME-N Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml[zTWM2OD1|LkK5OVEyKM7:TR?= NVvyNpRWW0GQR1XS
SW756 M2WzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j3ZmlEPTB;Mz6yPVYzQSEQvF2= MXnTRW5ITVJ?
RKO MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTNwM{C3OVch|ryP MkGyV2FPT0WU
NCI-H1563 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXEXlc4UUN3ME2zMlM{ODF6IN88US=> NIfzXYpUSU6JRWK=
DJM-1 M{TZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXr1THF2UUN3ME2zMlM4Pjd2IN88US=> M2T3dHNCVkeHUh?=
L-428 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC5UWF[UUN3ME2zMlQxODR3IN88US=> NGDQWXNUSU6JRWK=
NCI-H2122 NH3oTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;KOmlEPTB;Mz60NVMyOiEQvF2= MX7TRW5ITVJ?
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KURAMOCHI M1zNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfQTWM2OD1{OD6xNlYh|ryP M37Oe3NCVkeHUh?=
NCI-H1650 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TscWlEPTB;M{CuNVkzPCEQvF2= MYfTRW5ITVJ?
HCC1954 M2jmN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTufYtKSzVyPUOxMlM3PjZizszN NEnKbm1USU6JRWK=
GAK M2\Eemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPzTWM2OD1|Mj6yOlE3KM7:TR?= NH\id4pUSU6JRWK=
YAPC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXybnA4UUN3ME2zN{44PjR6IN88US=> NXPvcWIyW0GQR1XS
NCI-H2228 NWP3UYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TvcWlEPTB;M{SuN|YxPSEQvF2= M2r1UHNCVkeHUh?=
VMRC-RCZ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DJZWlEPTB;M{[uN|AzOiEQvF2= NW\Xd2NLW0GQR1XS
NMC-G1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN5LkC1Nlkh|ryP MkHFV2FPT0WU
D-336MG NUO4dnBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfENIJnUUN3ME20NU45PDR{IN88US=> MX7TRW5ITVJ?
UACC-62 MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTR{LkW1NFUh|ryP MnvPV2FPT0WU
C-33-A MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILqdoxKSzVyPUS1MlMzPTZizszN Mke5V2FPT0WU
HCC1937 NHfaeGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTR5LkG5OVgh|ryP NHf5em1USU6JRWK=
HDLM-2 NYPONYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTiU|g3UUN3ME20O{4zOjh5IN88US=> M{nz[XNCVkeHUh?=
NCI-H727 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH2Snh[UUN3ME20O{4zPDVzIN88US=> MoTTV2FPT0WU
NY M37Sbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTR7LkO5NFgh|ryP NIDqS4VUSU6JRWK=
NCI-H2291 NHjxfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrFenBKSzVyPUS5Mlg{ODFizszN NFy0ZY5USU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Water Insoluble
Ethanol '3 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms MK0683
Smiles ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Withdrawn Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID