Vorinostat (SAHA)

Name: Vorinostat (SAHA)
Brand: Selleck Chemicals
SKU: S1047
Rating: 5 (396 reviews)

For research use only.

Catalog No.S1047 Synonyms: MK0683

396 publications

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

Selleck's Vorinostat (SAHA) has been cited by 396 publications

Cell, 2020, S0092-8674(20)31394-5

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Nat Biotechnol, 2020, 10.1038/s41587-019-0388-4

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Cancer Cell, 2020, 13;37(4):599-617 e7

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Cell, 2019, 176(1-2):198-212

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 36(2):179-193

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Cell, 2018, 174(3):536-548.e21

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Cell Metab, 2018, 5;27(6):1294-1308.e7

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Nature, 2017, 551(7679):247-250

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Cancer Discov, 2017, 7(12):1450-1463

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Cancer Cell, 2016, 29(3):311-323

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Nat Biotechnol, 2015, 10.1038/nbt.3130

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Nat Med, 2015, 21(10):1163-71

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Nat Med, 2015, 10.1038/nm.3855

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Cell, 2014, 28;158(5):989-999.

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Nature, 2011, 10;471(7337):235-9.

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Nat Biotechnol, 2011, 29(3):255-65

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J Enzyme Inhib Med Chem, 2021, 36(1):34-47

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Sci China Life Sci, 2021, 10.1007/s11427-020-1855-4

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Adv Sci (Weinh), 2020, 7(21):2001364

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Sci Adv, 2020, 6(33):eaba6617

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Nucleic Acids Res, 2020, 10.1093/nar/gkaa088

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EMBO Rep, 2020, 21:e50162

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J Immunother Cancer, 2020, 8(2)e001037

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J Immunother Cancer, 2020, 8(1)

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Theranostics, 2020, 1;10(3):1433-1453

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Cancer, 2020, 1;126(9):2024-2033

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Cancers (Basel), 2020, 12(11)E3172

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PLoS Pathog, 2020, 16;16(3):e1008341

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Clin Epigenetics, 2020, 12(1):13

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Br J Cancer, 2020, 27

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Front Cell Dev Biol, 2020, 17;8:158

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J Neuroinflammation, 2020, 22;17(1):125

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ACS Infect Dis, 2020, 29

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Cancer Sci, 2020, 111(12):4429-4441

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Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0669

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Front Oncol, 2020, 10:296

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J Virol, 2020, 4;94(10) pii: e01923-19

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Biochem Pharmacol, 2020, 3;178:114067

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Cancer Cell Int, 2020, 19;20:58

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HIV Med, 2020, 21(11):747-757

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Am J Transl Res, 2020, 12(10):6187-6203

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Andrology, 2020, 10.1111/andr.12922

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BMC Microbiol, 2020, 20(1):28

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PLoS One, 2020, 15;15(5):e0232985

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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J Med Invest, 2020, 67(3.4):343-350

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Sci Rep, 2020, 10(1):12864

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Oncol Lett, 2020, 19(1):460-468

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Sci Adv, 2020, 6(29):eaba1941

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Colloids Surf B Biointerfaces, 2020, 188:110753

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Acta Pharm Sin B, 2020, 10(4):615-627

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Cancer Sci, 2020, 111(7):2374-2384

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Oncogene, 2020, 10.1038/s41388-020-01394-w

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Viruses, 2020, 12(10)E1067

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Oncogene, 2020, 10.1038/s41388-020-01408-7

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Br J Cancer, 2020, 10.1038/s41416-020-01191-y

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Mol Cancer Ther, 2020, 19(2):637-649

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Genes Dev, 2020, 34(5-6):428-445

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Cancer Manag Res, 2020, 12:4429-4439

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Biomater Sci, 2020, 10.1039/d0bm00119h

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Cell Cycle, 2020, 1-16

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Life Sci, 2020, 248:117469

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Chin Med J (Engl), 2020, 5;133(11):1304-1311

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Pharmaceuticals (Basel), 2020, 13(11)E345

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Pharm Biol, 2020, 58(1):231-238

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PLoS Biol, 2020, 18(12):e3000941

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PLoS Biol, 2020, 18(11):e3000981

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Nat Commun, 2019, 10(1):4192

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J Pineal Res, 2019, 66(3):e12556

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Haematologica, 2019, 10.3324/haematol.2018.211110

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Haematologica, 2019, 104(11):2225-2240

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Theranostics, 2019, 9(2):540-553

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Cancer Res, 2019, 79(7):1658-1670

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Cell Rep, 2019, 27(11):3331-3344

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Elife, 2019, 8

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Int J Cancer, 2019, 145(9):2496-2508

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Mol Ther, 2019, 27(5):1039-1050

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Cancers (Basel), 2019, 11(5)E645

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Cancers (Basel), 2019, 11(4)

PubMed: 30935067 ( click the link to review the publication )

Clin Epigenetics, 2019, 11(1):85

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Acta Pharm Sin B, 2019, 9(5):937-951

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Cells, 2019, 8(12)

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Cancer Discov, 2019, 9(4):526-545

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Front Immunol, 2019, 9:3162

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Mol Cancer Ther, 2019, 18(5):900-908

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Cell Commun Signal, 2019, 17(1):4

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Oncologist, 2019, 24(8):e740-e748

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Mol Oncol, 2019, 10.1002/1878-0261.12607

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Epigenetics, 2019, 10.1080/15592294.2019.1656155

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Epigenetics, 2019, 14(8):791-803

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Epigenetics, 2019, 10.1080/15592294.2019.1656156

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AIDS, 2019, 33(2):199-209

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Hum Mol Genet, 2019, 10.1093/hmg/ddz254

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Pharmacol Res, 2019, 139:524-534

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Pharmacol Res, 2019, 146:104281

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J Neurochem, 2019, 10.1111/jnc.14935

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Bone, 2019, 125:112-121

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Apoptosis, 2019, 24(5-6):404-413

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NMR Biomed, 2019, 32(2):e4044

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Cancer Biol Ther, 2019,

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Stem Cells Dev, 2019, 28(7):438-453

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Chem Biol Interact, 2019, 306:54-61

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Gene Ther, 2019, 26(3-4):75-85

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Cancer Med, 2019, 8(14):6383-6392

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Tuberculosis (Edinb), 2019, 118:101861

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ACS Omega, 2019, 4(22):19895-19904

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Exp Hematol, 2019, 72:60-71

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Nucl Med Biol, 2019, 74-75:1-11

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Alcohol, 2019, 78:79-87

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Anticancer Res, 2019, 39(7):3579-3584

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Neoplasma, 2019, 66(1):20-27

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Res Vet Sci, 2019, 126:207-212

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Exp Ther Med, 2019, 17(6):4547-4553

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Thyroid, 2019, 29(5):726-734

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Medicina (Kaunas), 2019, 55(2)

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Adipocyte, 2019, 8(1):292-303

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Oncol Rep, 2019, 41(2):1007-1018

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Chin J Dent Res, 2019, 22(4):221-227

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Front Neurol, 2019, 10:893

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Cell Host Microbe, 2018, 24(5):689-702

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Nat Commun, 2018, 13;9(1):2720

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Cancer Res, 2018, 78(10):2705-2720

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J Control Release, 2018, 275:117-128

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Haematologica, 2018, 103(4):679-687

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J Hematol Oncol, 2018, 11(1):32

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Cancer Lett, 2018, 432:121-131

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Acta Biomater, 2018, 71:261-270

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Sci Signal, 2018, 11(557)

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J Exp Clin Cancer Res, 2018, 37(1):153

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PLoS Pathog, 2018, 14(6):e1007061

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Oncoimmunology, 2018,

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Mol Cancer Ther, 2018, 17(12):2767-2779

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Cancer Sci, 2018, 109(8):2520-2531

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J Virol, 2018, 92(10)

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J Virol, 2018, 92(6)

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J Cell Mol Med, 2018, 22(5):2600-2611

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Sci Rep, 2018, 8(1):3521

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Front Microbiol, 2018, 9:2022

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J Cell Biochem, 2018, 119(5):4193-4204

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Retrovirology, 2018, 15(1):36

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Exp Cell Res, 2018, 371(1):231-237

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BMC Cancer, 2018, 18(1):466

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Oncol Rep, 2018, 39(1):264-270

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Ann Hematol, 2018, 97(5):839-849

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Biochem Biophys Res Commun, 2018, 498(3):481-486

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AAPS PharmSciTech, 2018, 19(2):634-647

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Cell Biochem Funct, 2018, 36(8):398-407

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J Med Virol, 2018, 90(9):1478-1485

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Curr Protoc Pharmacol, 2018, 81(1):e41

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Alcohol Clin Exp Res, 2018, 42(11):2160-2171

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Oncol Lett, 2018, 15(5):6107-6114

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JCI Insight, 2018, 3(4)95824

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Sci Adv, 2018, 4(9):eaar4666

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JCI Insight, 2018, 3(22)125568

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Nat Struct Mol Biol, 2017, 24(1):47-54

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Clin Cancer Res, 2017, 23(12):3139-3149

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Proc Natl Acad Sci USA, 2017,

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Haematologica, 2017, 102(4):736-745

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Clin Cancer Res, 2017, 23(12):3084-3096

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Oncogene, 2017, 36(34):4859-4874

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Oncogene, 2017, 36(12):1707-1720

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Br J Pharmacol, 2017, 174(20):3608-3622

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Sci Signal, 2017, 10(508)eaan8355

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Cell Death Dis, 2017, 8(1):e2570

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Cell Death Dis, 2017,

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Mol Ther Oncolytics, 2017,

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Cell Chem Biol, 2017, 24(11):1356-1367.e8

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Cancer Discov, 2017, 7(12):1450-1463

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Eur J Med Chem, 2017, 127:531-553

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Eur J Med Chem, 2017, 141:596-602

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Cancer Sci, 2017, 108(7):1485-1492

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Int J Mol Sci, 2017, 18(5)

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Sci Rep, 2017, 7(1):11547

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J Biol Chem, 2017, 292(12):5043-5054

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J Pharmacol Exp Ther, 2017, 363(2):211-220

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Pharm Res, 2017, 34(3):668-679

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Cancer Res Treat, 2017, 49(2):374-386

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Cancer Med, 2017, 6(11):2673-2685

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Int J Cell Biol, 2017, 2017:6169310

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PLoS One, 2017, 12(10):e0186620

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Connect Tissue Res, 2017, 58(1):64-75

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Pulm Pharmacol Ther, 2017, 44:88-95

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Am J Surg, 2017, 213(4):645-651

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Nucleus, 2017, 8(5):515-533

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Oncotarget, 2017, 8(11):17995-18009

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Oncotarget, 2017, 9(1):512-523

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Oncotarget, 2017, 8(31):51429-51446

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CPT Pharmacometrics Syst Pharmacol, 2017, 6(11):756-764

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Sci Rep, 2017, 7(1):2290

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Oncotarget, 2017, 8(45):78480-78495

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JCI Insight, 2017, 2(1):e85811

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Oncotarget, 2017,

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JCI Insight, 2017, 2(6):e90196

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Bioorg Med Chem, 2017, 25(7):2105-2132

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Oncotarget, 2017,

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Oncotarget, 2017, 10.18632/oncotarget.15017

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Oncotarget, 2017, 8(44):77254-77267

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Cell Host Microbe, 2017, 21(5):569-579

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Ann Oncol, 2016, 27(3):508-13

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Nat Commun, 2016, 7:11363

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Cancer Res, 2016, 76(23):7001-7011

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Cancer Res, 2016, 76(8):2376-83

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Int J Cancer, 2016, 139(1):194-204

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Drug Discov Today, 2016, 21(9):1553-1560

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mBio, 2016, 7(6)

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J Med Chem, 2016, 59(4):1613-33

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Oncoimmunology, 2016,

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Mol Cancer Ther, 2016, 15(6):1364-75

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Mol Cell Proteomics, 2016, 15(6):2076-92

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ACS Chem Biol, 2016, 11(10):2685-2692

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Neuropharmacology, 2016, 107:111-121

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Biochem Pharmacol, 2016, 102:130-140

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Sci Rep, 2016, 6:38219

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Am J Pathol, 2016, 186(10):2701-8

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J Biol Chem, 2016, 291(19):10131-47

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Neurochem Int, 2016, 96:24-31

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Int J Oncol, 2016, 49(6):2453-2463

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Cancer Biol Ther, 2016, 17(1):27-35

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Anal Bioanal Chem, 2016, 408(13):3547-53

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BMC Cancer, 2016, 16:667

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Biol Chem, 2016,

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J Hum Genet, 2016, 10.1038/jhg.2016.61

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Med Oncol, 2016, 33(2):11

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Inflammation, 2016, 39(1):39-46

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PLoS One, 2016, 11(8):e0160826

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Oncotarget, 2016,

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Oncotarget, 2016, 7(36):58142-58147

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Sci Rep, 2016, 6:21678

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Oncotarget, 2016, 7(6):6727-47

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Nat Commun, 2015, 6:7888

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Cancer Res, 2015,

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Mol Med Rep, 2015, 12(3):4291-4297

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Cancer Lett, 2014, 351(1):50-8

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PLoS Pathog, 2014, 10(4):e1004071

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Cell Death Dis, 2014, 5:e1134

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Cell Death Dis, 2014, 5:e1177

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Mol Cancer Ther, 2014, 13(12):2784-92

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J Mol Biol, 2014, 426(20):3442-53

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Hum Gene Ther, 2014, 25(7):599-608

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J Biol Chem, 2014, 289(14):9918-25

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Cancer Cell Int, 2014, 10.1186/s12935-014-0112-x

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Cancer Cell Int, 2014, 14(1):112

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Mol Cell Biol, 2014, 34(7):1280-9

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Proteomics Clin Appl, 2014, 8(11-12):924-31

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J Alzheimers Dis, 2014, 41(4):1193-205

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Cancer Biol Ther, 2014, 15(5):578-85

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Cancer Biol Ther, 2014, 15(3):305-16

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BMC Cancer, 2014, 14(1):373

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FEBS Lett, 2014, 588(9):1571-9

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PLoS One, 2014, 9(11):e113341

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Mol Med Rep, 2014, 10(5):2729-35

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Oncol Lett, 2014, 7(5):1673-1678

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Oncotarget, 2014, 5(14):5637-50

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Pharmacol Res Perspect, 2014, 2(3):e00043

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Pharmacology Research Perspectives, 2014, 10.1002/prp2.43

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Oncotarget, 2014, 5(15):5965-77

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Blood, 2013, 14;121(11):2038-50

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Blood, 2013, 123(5):706-16

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Proc Natl Acad Sci USA, 2013, 111(3):E364-73

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PLoS Biol, 2013, 12(1):e1001758

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Cancer Res, 2013, 73(8):2428-34

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Cell Rep, 2013, 5(6):1679-89

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Int J Cancer, 2013, 132(9):2200-8

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Neuropsychopharmacology, 2013, 38(9):1674-84

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Oncogene, 2013, 33(33):4265-72

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Oncogene, 2013, 32(10):1316-29

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Cell Death Dis, 2013, 4:e733

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Cell Death Dis, 2013, 4:e951

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Br J Haematol, 2013, 160(2):188-98

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AIDS, 2013, 27(18):2853-62

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PLoS Comput Biol, 2013, 9(2):e1002887

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Mol Carcinog, 2013, 52(3):218-28

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J Thromb Thrombolysis, 2013, 35(2):185-92

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Cell Death Dis, 2013, 4:e655

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Blood, 2012, 8;120(19):3958-67

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Sci Signal, 2010, 3(146):ra80

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Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

Targets

HDAC ^[1]
(Cell-free assay)

~10 nM

In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. ^[1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. ^[2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. ^[3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
H1299	M4P0eWtqdmG\|ZTDBd5NigQ>?		M1;xNVIxKG2rbh?=	NH75epRFVVOR	M2DNcGlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDV{MUSyNkc,OTR3MkG0NlI9N2F-
HT1080	NX25flB5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MX23NkBp	NFrXdoRFVVOR	NVziWJZ4UUN3ME2yMlQh\|ryP	NWGyTlFKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKyO\|AyPzVpPkGyNlcxOTd3PD;hQi=>
K562	M4f1fWtqdmG\|ZTDBd5NigQ>?		M1;RTlYhcA>?	NF7wcZdFVVOR	NFO3bWNKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0>	NFi5b4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkSxPVM5OCd-MUK0NVk{QDB:L3G+
A20	MVHLbY5ie2ViQYPzZZk>		MVyxJIg>	NXLPUJV5TE2VTx?=	NHj6cGJidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2=	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTl4MES4PUc,OTF7NkC0PFk9N2F-
Friend leukemic cell	M3LTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYS1NEDPxE1?	M1PMRVczKGh?	NE\1Z5JFVVOR	NEDy[YtKSzVyPUCuPVkh\|ryP	NYXNUWhFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKxNFk6OTNpPkGyNVA6QTF\|PD;hQi=>
H1299	NUiyblNpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M{C0elczKGh?	MWDEUXNQ	MUHJR\|UxRTdwMkSg{txO	NF\tVmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNEWyNVQzOid-MUS1NlE1OjJ:L3G+
HeLa	NGjsXZlMcW6jc3WgRZN{[Xl?		NGfpS2c{OCCvaX6=		NX2wfFBnUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1?	M3H5bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NkCzPVQ6Lz5zNU[wN\|k1QTxxYU6=
LOX-IMVI	NYTvcVNMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MW[0PEBp		M{jnUWlEPTB;MT6zJO69VQ>?	M{m4flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3N{G1OFcxLz5zNUexOVQ4ODxxYU6=
NCI-H226	M2LJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M3nyVFQ5KGh?		MYPJR\|UxRTJwNjFOwG0>	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTdzNUS3NEc,OTV5MUW0O\|A9N2F-
RXF-631L	M{n4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M3XQWlQ5KGh?		NGXoUVNKSzVyPUKg{txO	NIP6dHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUexOVQ4OCd-MUW3NVU1PzB:L3G+
SNB-78	M2jvXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M3H2bVQ5KGh?		NHHDOphKSzVyPUG2JO69VQ>?	NFr6Om49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUexOVQ4OCd-MUW3NVU1PzB:L3G+
St-4	NULNVmJZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MW[0PEBp		M1n1SWlEPTB;NT6yJO69VQ>?	NYO2NYdmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW3NVU1PzBpPkG1O\|E2PDdyPD;hQi=>
ARP1	M{XySGZ2dmO2aX;uJGF{e2G7	NUHWTYIyOiEQvF2=	MV62JIg>		NFn2bGhKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44>	MoXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTR5M{S4NFYoRjF2N{O0PFA3RC:jPh?=
CEM	NHPkNVVMcW6jc3WgRZN{[Xl?		NUfZSottOSCq	M1HVfmROW09?	MX3Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO	NGCxUWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkSyNFA3PCd-MU[0NlAxPjR:L3G+
HCT15	NH3iSWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MmfwOFghcA>?		NFzsZm1IUTVyPUCuPFIh\|ryP	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd{M{KyO{c,OTZ5MkOyNlc9N2F-
NCI-H23	NHzvenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1\GVFQ5KGh?		MlnlS2k2OD1yLkmyJO69VQ>?	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd{M{KyO{c,OTZ5MkOyNlc9N2F-
GM15850	NIXaZ\|ZMcW6jc3WgRZN{[Xl?	NEfafnQzNjVizszN	Mm\CPVYhcA>?	M3\2cGROW09?	NFPyOndKdmirYnn0bY9vKG:oIFjERWMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW=	M1PMclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN\|Y4Lz5zNkmyNVM3PzxxYU6=
GM15850	MXnLbY5ie2ViQYPzZZk>	MUGyMlUh\|ryP	MYG5OkBp	NEfBZ2FFVVOR	NFvwXXNKdmirYnn0bY9vKG:oIFjERWMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?=	MoXjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN\|Y4RC:jPh?=
GM15850	MoO1T4lv[XOnIFHzd4F6	M{HCb\|IvPSEQvF2=	NXiwVodoQTZiaB?=	NHLxWWZFVVOR	MYrJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMUKgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV?	MoT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN\|Y4RC:jPh?=
GM15850	NXjHVVBXU2mwYYPlJGF{e2G7	M2GzWVIvPSEQvF2=	M2HBUFk3KGh?	MWTEUXNQ	Mm\WTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV?	M4XMWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN\|Y4Lz5zNkmyNVM3PzxxYU6=
GM15850	MYXLbY5ie2ViQYPzZZk>	NEPYbZczNjVizszN	MmTYPVYhcA>?	NWT1do17TE2VTx?=	M4nzOGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n	Mlr6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN\|Y4RC:jPh?=
GM15850	M4LDc2tqdmG\|ZTDBd5NigQ>?	NGXwV\|kzNjVizszN	NUHDc\|dqQTZiaB?=	MlnlSG1UVw>?	M4i2d2lvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxOkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?=	MnjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN\|Y4RC:jPh?=
U937	NWixWHlxTnWwY4Tpc44hSXO\|YYm=	MUW1JO69VQ>?	M13QPFI1KGh?	NGK2T3BFVVOR	NED2NYlE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn	Mn;zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyMES3NVgoRjF5MEC0O\|E5RC:jPh?=
H661	NH\jc5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NWTDXpVzPDhiaB?=		NHX5[oFKSzVyPUGg{txO	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3N{CwPUc,OTdzNUewNFk9N2F-
U937	MX7GeY5kfGmxbjDBd5NigQ>?	MXi1JO69VQ>?	MUmyOEBp	M{DoVGROW09?	NFXHUWxKdmO{ZXHz[UBqdiCqaYP0c45mKEh\|IHHj[ZR6dGG2aX;u	NGrnTWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0O\|c2OCd-MUe0OFc4PTB:L3G+
U937	M1jqUmZ2dmO2aX;uJGF{e2G7	NWnTTYJrOSEQvF2=	NEnpZpAzPCCq	M{\BVmROW09?	NEH5TVRG\m[nY4Sgc44h[WyyaHGgeJVjfWyrbjDhZ4V1gWyjdHnvci=>	NXeyTlJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OFc4PTBpPkG3OFQ4PzVyPD;hQi=>
RAW264.7	M2SxS2Z2dmO2aX;uJGF{e2G7	M4HCSVExKM7:TR?=	NEX2eIYzPGh?	NX:xR2d[f2G2ZYK=	MljRTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?=	MmP6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd2N{e1NVgoRjF5NEe3OVE5RC:jPh?=
RAW264.7	MYnGeY5kfGmxbjDBd5NigQ>?	MkK5NVAh\|ryP	MXWyOIg>	NEX1RnR4[XSnch?=	MWLJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJG5QKHC{b3T1Z5Rqd25id3n0bEBKSzVyIH;mJFEvQDhizszN	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR5N{WxPEc,OTd2N{e1NVg9N2F-
SC9	NHfRcnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MV:0PEBp		MnfuTWM2OD1yLk[wOkDPxE1?	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzVyN{KxPUc,OTd3MEeyNVk9N2F-
ST14A	NVz2fmRpTnWwY4Tpc44hSXO\|YYm=	NFjQVYI2KG6P	M13JdVczKGh?		Mlj0TY5kemWjc3WgbY4hWkWVVD;OVnNHKG2UTlGg[ZhxemW\|c3nvci=>	NHzvT5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W2OVk6Oyd-MUe1OlU6QTN:L3G+
ST14A	NYXFdld[TnWwY4Tpc44hSXO\|YYm=	MWq1JI5O	M1zKSFczKGh?		MmDYTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25?	NYPP[W0yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1OlU6QTNpPkG3OVY2QTl\|PD;hQi=>
PANC1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4ThflEh\|ryP			NUH6NZR2UUN3ME2wMlQ2KM7:TR?=	NFPJU4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFc1PCd-MUe1PFg4PDR:L3G+
PANC1	NXfpNnJqTnWwY4Tpc44hSXO\|YYm=	M{LwRlEh\|ryP	MmXENlQhcA>?		NWiyZ5U6UW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?=	NV33[Y9uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1PFg4PDRpPkG3OVg5PzR2PD;hQi=>
PANC1	MXHGeY5kfGmxbjDBd5NigQ>?	MV2xJO69VQ>?	MorLNlQhcA>?		M1rGN2lv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO\|aX;u	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzV6OEe0OEc,OTd3OEi3OFQ9N2F-
PT45	NHL3W2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWWwW3NFUUN3ME20JO69VQ>?	M1XPWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUi4O\|Q1Lz5zN{W4PFc1PDxxYU6=
ACHN	M{S2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVz2SIhCOjFiaB?=		NIPOUHhIUTVyPUCuOlUh\|ryP	M3r2PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nk[yOlA3Lz5zN{[2NlYxPjxxYU6=
PC3	NH\zOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MViyNUBp		NIfNb3VIUTVyPUCuO\|Eh\|ryP	M3;4Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Nk[yOlA3Lz5zN{[2NlYxPjxxYU6=
A431	NUL0eG84S3m2b4TvfIlkKEG\|c3H5		M3LYflczKGh?		NFnyRphKSzVyPUSuNkDPxE1?	M{PSRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkmxO\|Y{Lz5zN{[5NVc3OzxxYU6=
Cal27	NXzpd44zS3m2b4TvfIlkKEG\|c3H5		M1\Ic\|czKGh?		MVTJR\|UxRTNwMjFOwG0>	M3z4VVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkmxO\|Y{Lz5zN{[5NVc3OzxxYU6=
CCRF-CEM	MXPDfZRwfG:6aXOgRZN{[Xl?		MYi3NkBp		MUTJR\|UxRTBwODFOwG0>	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ7MUe2N{c,OTd4OUG3OlM9N2F-
EOL1	MmXpR5l1d3SxeHnjJGF{e2G7		NFrTNI44OiCq		NGHqelZKSzVyPUGg{txO	MnOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OUG3OlMoRjF5NkmxO\|Y{RC:jPh?=
Hec-1-A	Mk\oR5l1d3SxeHnjJGF{e2G7		M37kS\|czKGh?		MXrJR\|UxRTFizszN	NYD1[ZRoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVE4PjNpPkG3OlkyPzZ\|PD;hQi=>
HeLa	M{Lze2tqdmG\|ZTDBd5NigQ>?	MVKxNEDPxE1?	MXKzNEBucW5?	MX3EUXNQ	NWjE[3lYUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBJTEGFMTD3bZRpKEmFNUCgc4YhOC5yMjFOwG0>	NYLZUGIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVE4PjNpPkG3OlkyPzZ\|PD;hQi=>
RKOp21	M4ewOGN6fG:2b4jpZ{BCe3OjeR?=		M2TH[VczKGh?		NXjrWVRzUUN3ME2xMlc3KM7:TR?=	NXTMOW1FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVE4PjNpPkG3OlkyPzZ\|PD;hQi=>
Saos2	NETIPFNEgXSxdH;4bYMhSXO\|YYm=		M4L3TVczKGh?		MVTJR\|UxRTJwMzFOwG0>	NX;OOlNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe2PVE4PjNpPkG3OlkyPzZ\|PD;hQi=>
SK-OV-3	MYPDfZRwfG:6aXOgRZN{[Xl?		NFnCNoU4OiCq		NEPiT\|hKSzVyPUKuNkDPxE1?	MlrBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OUG3OlMoRjF5NkmxO\|Y{RC:jPh?=
U87MG	MmTlR5l1d3SxeHnjJGF{e2G7		MmmxO\|IhcA>?		NH[yWXNKSzVyPUGxJO69VQ>?	NFnlbHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[5NVc3Oyd-MUe2PVE4PjN:L3G+
NUGC3	M3:xUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTnOUDPxE1?	NYjXT\|lGOjRiaB?=		MkHrS2k2OD1{Lke5JO69VQ>?	M1HYb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OUC0PFQ{Lz5zN{mwOFg1OzxxYU6=
CCD1059SK	NWH6OHNJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3yzSmlEPTB;NEOuOUDPxE1?	M1\IOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkS3OVU1Lz5zOEK0O\|U2PDxxYU6=
HepG2	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVjJR\|UxRTBwMECwOkDPxE1?	Mn3xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{NEe1OVQoRjF6MkS3OVU1RC:jPh?=
HT1080	M1rtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXLJR\|UxRTBwMECyOEDPxE1?	NIfTN5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK0O\|U2PCd-MUiyOFc2PTR:L3G+
SKBR3	Mn\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnPOTWM2OD1yLkig{txO	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ2N{W1OEc,OTh{NEe1OVQ9N2F-
SNB78	NFP4[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUDFR\|UxRTF4IN88US=>	NH7xZoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK0O\|U2PCd-MUiyOFc2PTR:L3G+
SQ20B	M3TwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmroTWM2OD1\|IN88US=>	NEXWS4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK0O\|U2PCd-MUiyOFc2PTR:L3G+
St4	MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWnFR\|UxRTVwMjFOwG0>	NWD5UINbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOFc2PTRpPkG4NlQ4PTV2PD;hQi=>
MCF7	M1\BWWZ2dmO2aX;uJGF{e2G7	M33FZlExKM7:TR?=	M33SRVghcA>?	NYDRdWZ1TE2VTx?=	M173Nmlv\HWldHnvckBw\iC2dXL1cIlvKGi7cHXyZYNmfHmuYYTpc44>	NGjZWpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK2PVIzPid-MUiyOlkzOjZ:L3G+
HEK293	M3fyZmtqdmG\|ZTDBd5NigQ>?		MkHHNUBp	NFLwfIdFVVOR	NIXpcJJKdmirYnn0bY9vKG:oIFjERWMyKHerdHigTWM2OCCxZjCwMlA{KM7:TR?=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDNyOEW2N{c,OTh\|MEi1OlM9N2F-
HEK293	MmnGT4lv[XOnIFHzd4F6		M4jkRlEhcA>?	NVzDZVBZTE2VTx?=	M{TLVmlvcGmkaYTpc44hd2ZiSFTBR\|Mhf2m2aDDJR\|UxKG:oIECuNFU4KM7:TR?=	M2XmcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{C4OVY{Lz5zOEOwPFU3OzxxYU6=
G401	NYLLPIhjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NIfkc4E4OiCq	NILJe\|NFVVOR	NGexNZlKSzVyPUGg{txO	MoO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|N{CzO\|MoRjF6M{ewN\|c{RC:jPh?=
HeLa	M4SyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MXy3NkBp	NUXkUVBLTE2VTx?=	NF\1fGNKSzVyPUCuOFYh\|ryP	MlzRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh\|N{CzO\|MoRjF6M{ewN\|c{RC:jPh?=
Human renal epithelial cell	M{\rZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MmXVO\|IhcA>?	MlvaSG1UVw>?	MXXJR\|UxRTF2IN88US=>	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN5MEO3N{c,OTh\|N{CzO\|M9N2F-
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U937	NI\ldWlHfW6ldHnvckBCe3OjeR?=	MnX5OUDPxE1?	NH;pTI0zPCCq		MkT4TY5lfWO2aX;uJI9nKGGyb4D0c5Nqew>?	M{jkT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{ixNlM5Lz5zOEO4NVI{QDxxYU6=
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U937	NFv5NVNMcW6jc3WgRZN{[Xl?	NFzZSI42KM7:TR?=	NHjyfoEzPCCq		MWDJcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN2	NHPyTZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEO4NVI{QCd-MUizPFEzOzh:L3G+
HEK-TE	NF:3RVdHfW6ldHnvckBCe3OjeR?=	MY[1JO69VQ>?	NWDMfoVlPmh?	MVHEUXNQ	M3z6bmlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36=	Ml;VQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2M{SxOFQoRjF6NEO0NVQ1RC:jPh?=
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Human microvascular epithelial cell	NFK2NZFEgXSxdH;4bYMhSXO\|YYm=	MYm1NEDPxE1?	NEe0UHg4OiCq	MkHwSG1UVw>?	NVXHOlkxUUN3ME2xMlMh\|ryP	MkDMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2OUS0OlMoRjF6NEm0OFY{RC:jPh?=
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RAW264.7	NG\KTHJHfW6ldHnvckBCe3OjeR?=	MkXVNkDPxE1?	NYD0U4ZiOy53IHi=	MXvEUXNQ	MWXBcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBRdGG\|bX;kbZVuKG[jbHPpdIFzfW1iaX7m[YN1\WRid3n0bEBKSzVyIH;mJFAvOTFizszN	NWn0cYRrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2OFQ6PjlpPkG4OlQ1QTZ7PD;hQi=>
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HCT116	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NFu5ZYM4Omh?	MW\EUXNQ	M1;1[GlEPTB;MD6zNUDPxE1?	M3\pcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEi0Nlk1Lz5zOUC4OFI6PDxxYU6=
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IGROV1	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NWHiR5k1PzJiaB?=	NFzYOI1FVVOR	M1XPZmlEPTB;Mj6yJO69VQ>?	NVPUPIpTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPFQzQTRpPkG5NFg1Ojl2PD;hQi=>
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IGROV1	NFjQ[4ZMcW6jc3WgRZN{[Xl?	NGr6TYEyOCEQvF2=	MkLDOEBp	MWXEUXNQ	NUHkR49yUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w	NUn0RlAxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwPFQzQTRpPkG5NFg1Ojl2PD;hQi=>
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T24	NFqw[3ZMcW6jc3WgRZN{[Xl?		NYDvTlRFOyCq		NHe1W5RKdmS3Y4Tpc44hd2ZiYXzwbIEhfHWkdXzpckBi[2W2eXzheIlwdiC5aYToJGVEPTBib3[gNE4zPSEQvF2=	M{DWelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7MEi0N\|k2Lz5zOUC4OFM6PTxxYU6=
HeLa	NIPyOotMcW6jc3WgRZN{[Xl?		NX7iRWx6OTVibXnu	MoKxSG1UVw>?	Mlv6TY5pcWKrdHnvckBw\iCKRFHDOkBnem:vIH71Z4xm[XJiZYj0doFkfCC5aYToJGlEPTBib3[gNE4xQDV3IN88US=>	NH3xVXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC5N\|g5PCd-MUmwPVM5QDR:L3G+
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NCI-H69	MWDDfZRwfG:6aXOgRZN{[Xl?		M2rUXlczKGh?	NHv2NnRFVVOR	NHLodYlKSzVyPUKuNFYh\|ryP	NGrZOJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC5N\|g5PCd-MUmwPVM5QDR:L3G+
SKMES1	MoLBR5l1d3SxeHnjJGF{e2G7		M2HnSFczKGh?	Mkm1SG1UVw>?	NVjXWIJLUUN3ME2yMlQzKM7:TR?=	NHT4SXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUC5N\|g5PCd-MUmwPVM5QDR:L3G+
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SHSY5Y	Mlj4T4lv[XOnIFHzd4F6	M2HJXFExKM7:TR?=	NXzMOo9CPDhiaB?=	MnTqSG1UVw>?	MUDJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNTFOwG0>	NGrkZ289[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO0OFE4PSd-MUmzOFQyPzV:L3G+
SHSY5Y	M2LXfmN6fG:2b4jpZ{BCe3OjeR?=	NEj3RpgyOCEQvF2=	NVL3R2I4PDhiaB?=	MmjJSG1UVw>?	NU\FZ5RKUUN3ME2yJO69VQ>?	NX:5NIhxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmzOFQyPzVpPkG5N\|Q1OTd3PD;hQi=>
DMS114	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NF[4OJM1QCCq		NI\3PXdIUTVyPUKuPUDPxE1?	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTRzOUKwOUc,OTl2MUmyNFU9N2F-
HBC5	MkXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWP2em86PDhiaB?=		MmTzS2k2OD1zNzFOwG0>	NXjMNVRMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm0NVkzODVpPkG5OFE6OjB3PD;hQi=>
SNB78	M3G2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MXq0PEBp		NF;qUm5IUTVyPUG2JO69VQ>?	M3HKVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7NEG5NlA2Lz5zOUSxPVIxPTxxYU6=
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BHK	NXH4T\|dmU2mwYYPlJGF{e2G7	NIfGW4o2KM7:TR?=	NUf1OFNSOjRiaB?=	MWXEUXNQ	NHf5[oVKdmirYnn0bY9vKG:oIFjERWM4KGW6cILld5Nm\CCjc4Pld5Nm\CCjczDpcoNz\WG\|ZTDpckBxdGG\|bXGgcYVu[nKjbnWgSoRmdHSjNUC4JGNHXFJicILveIVqdg>?	MmLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7Nk[3PFkoRjF7OU[2O\|g6RC:jPh?=
CFBE41o-	MoLiT4lv[XOnIFHzd4F6	NXXWWFhoPSEQvF2=	MWq4JIg>	M1;0UGROW09?	NIK1T5BKdmirYnn0bY9vKG:oIFjERWMh[XO\|ZYPz[YQh[XNiaInw[ZJi[2W2eXzheIlwdiCxZjDobZN1d26nIFiz	NIjRTpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm2Olc5QSd-MUm5OlY4QDl:L3G+
CFBE41o-	M4TNVWtqdmG\|ZTDBd5NigQ>?	NEjLeXU2KM7:TR?=	M2DMcFQhcA>?	MVTEUXNQ	Ml\yTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIH31eIFvfCCIZHXseIE2ODhiQ1\UVkBxem:2ZXnuJIxmfmWu	MmfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7Nk[3PFkoRjF7OU[2O\|g6RC:jPh?=
CFBE41o-	MVzLbY5ie2ViQYPzZZk>	MWexJO69VQ>?	M3joTVEhcA>?	MljhSG1UVw>?	MoD2TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIFPGWHIheHKxdHXpckBt\X[nbB?=	M1yxTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OU[2O\|g6Lz5zOUm2Olc5QTxxYU6=
Primary bronchial epithelial cell	NGnUU\|hMcW6jc3WgRZN{[Xl?	NYHQbYJoOSEQvF2=	M3;ueFI1KGh?	MYTEUXNQ	NInkPYpKdmirYnn0bY9vKG:oIFjERWM4KGG\|c3Xzd4VlKGG\|IHnu[JVkfGmxbjDv[kBufXSjboSgSoRmdHSjNUC4JGNHXFJicILveIVqdiCjcHnjZYwhe3W{ZnHj[UBtd2OjbHn6ZZRqd25?	NXe1SnZNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OlY4QDlpPkG5PVY3Pzh7PD;hQi=>
CFBE41o-	MUPLbY5ie2ViQYPzZZk>	NE\HZ3QyKM7:TR?=	MmmxOUBl[Xm\|	NVrYNlBsTE2VTx?=	NETKZYVKdmirYnn0bY9vKG:oIFjERWM4KGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIHnuJJN1[WKrbHn6ZZRqd25ib3[gSoRmdHSjNUC4JGNHXFJicILveIVqdg>?	MoPnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7Nk[3PFkoRjF7OU[2O\|g6RC:jPh?=
CFBE41o-	Mlz0T4lv[XOnIFHzd4F6	Ml\5NUDPxE1?	NVfoSIg6OjRiaB?=	M3K5V2ROW09?	Ml7QTY5pcWKrdHnvckBw\iCKRFHDO{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDG[IVtfGF3MEigR2ZVWiCycn;0[YlvKHS{YX\mbYNscW6p	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl4Nke4PUc,OTl7Nk[3PFk9N2F-
CFBE41o-	NGnpNGRMcW6jc3WgRZN{[Xl?	NHnnVW02KM7:TR?=	Mki0NlQhcA>?	MlfOSG1UVw>?	MXLJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIILheIUhd2ZibXH0eZJifGmxbjDv[kBETlSUIIDyc5RmcW5idH:gbZR{KGeueXPv[o9zdQ>?	NIOxVZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm2Olc5QSd-MUm5OlY4QDl:L3G+
CFBE41o-	M4rnXmtqdmG\|ZTDBd5NigQ>?	NXXFfVB{PSEQvF2=	MmLtNlQhcA>?	NUXMZ4QxTE2VTx?=	MUnJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIIP0ZYJqdGm2eTDv[kBH\GWudHG1NFghS0[WUjDwdo91\Wmw	NWDvUIl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OlY4QDlpPkG5PVY3Pzh7PD;hQi=>
CFBE41o-	NWH4XnFXU2mwYYPlJGF{e2G7	MlrSOUDPxE1?	M17rZ\|I1KGh?	MV7EUXNQ	NEG4cXdKdmirYnn0bY9vKG:oIFjERWM4KGG\|c3Xzd4VlKGG\|IHPvdpJm[3Srb36gc4YhdXW2YX70JGZl\Wy2YUWwPEBETlSUIITyZYZncWOtaX7nJJRwKGOnbHygd5Vz\mGlZTDhd{BodHmlb3\vdo0>	NWqzbnBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5OlY4QDlpPkG5PVY3Pzh7PD;hQi=>
Primary bronchial epithelial cell	MUnLbY5ie2ViQYPzZZk>	MonTOUDPxE1?	MlvVNlQhcA>?	Ml3hSG1UVw>?	MYLJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO\|ZXSgZZMhcW6mdXP0bY9vKG:oIH31eIFvfCCIZHXseIE2ODhiQ1\UVkBxem:2ZXnuJIFxcWOjbDDzeZJn[WOnIHzvZ4FtcXqjdHnvci=>	Ml;XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7Nk[3PFkoRjF7OU[2O\|g6RC:jPh?=
Primary bronchial epithelial cell	MVvLbY5ie2ViQYPzZZk>	M1XzOlEh\|ryP	MUO5OkBp	NH7oWIZFVVOR	MXzJcohq[mm2aX;uJI9nKEiGQVO3JIF{e2W\|c3XkJIF{KGmwY4LlZZNmKGmwIIPoc5J1KGOrcnP1bZQh[3W{cnXueJM>	NEniW2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm2Olc5QSd-MUm5OlY4QDl:L3G+
BxPC3	M3;Scmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NVjjfIFRPzJiaB?=		NIPvRpVKSzVyPUKuO{DPxE1?	NUSxd\|JpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
CAL27	Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3LK[lczKGh?		M2f3bmlEPTB;Mz63NkDPxE1?	NUTHNoFYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
Capan1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M2HodlczKGh?		NH\a[YlKSzVyPUeuN{DPxE1?	NY[3S4FLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
HCC827	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MUG3NkBp		NVHPZYUzUUN3ME2xMlgh\|ryP	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{e3PEc,OjBzNEO3O\|g9N2F-
LNCAP	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M13XelczKGh?		NFvFbXhKSzVyPUCuOVgh\|ryP	NUfHW5BYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
NCI-H2122	M2XReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MWq3NkBp		NH7zRpJKSzVyPUeuOUDPxE1?	NHGzOJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|c4QCd-MkCxOFM4Pzh:L3G+
NCI-H358	NY\URpRyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NYjrZ3JFPzJiaB?=		MYjJR\|UxRTJwNTFOwG0>	MmHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O\|goRjJyMUSzO\|c5RC:jPh?=
SCC15	MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MUS3NkBp		M1LjOWlEPTB;Mj60PUDPxE1?	MlfwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O\|goRjJyMUSzO\|c5RC:jPh?=
SCC25	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MnzxO\|IhcA>?		MWXJR\|UxRTFwOUOg{txO	NWTpS49RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
SKHEP1	NYH6RYd{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NGm2[lk4OiCq		NFfhb\|hKSzVyPUOuOFYh\|ryP	MnO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O\|goRjJyMUSzO\|c5RC:jPh?=
BJ	Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2POcFExOCEQvF2=	MmO1OFghcA>?	NHu5WmhFVVOR	M1PneGdzd3e2aDDpcohq[mm2aX;uJIF1KDBwMEWgeI8hOTByIIXN	M16yXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N\|g1ODxxYU6=
MUF	NULoRplqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NULzfG9EOTByIN88US=>	Mmn1OFghcA>?	MYXEUXNQ	MWfHdo94fGhiaX7obYJqfGmxbjDheEAxNjB3IITvJFExOCC3TR?=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
Caco-2	NUfyUYE{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWqxNFAh\|ryP	NELHZpo1QGh?	MknySG1UVw>?	NFLYVYpKSzVyPUiuNUDPxE1?	M1vQd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N\|g1ODxxYU6=
Caco-2	NGLNZWVMcW6jc3WgRZN{[Xl?	MmCwOUDPxE1?	M3vKbFQhcA>?	MU\EUXNQ	MY\JcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;uJGlEPTBib3[gNE4xOzdizszN	NEL6U2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|g1OCd-MkCxOFM5PDB:L3G+
Caco-2	NWjYUZpvU2mwYYPlJGF{e2G7	Mm[2NE4{OTZibl2geI8hOzFwNjFOwG0>	MYO0JIg>	NFy1U2ZFVVOR	NGnxSnlGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>?	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
Caco-2	M1T0O2tqdmG\|ZTDBd5NigQ>?	MVSwMlMyPiCwTTD0c{A{OS54IN88US=>	NUTVboEyPCCq	MlPzSG1UVw>?	NFnvXGRGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>?	NVjiPJE3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM5PDBpPkKwNVQ{QDRyPD;hQi=>
Caco-2	NFPicG9McW6jc3WgRZN{[Xl?	MVW2MlMzKG6PIITvJFY{OiEQvF2=	MmHIOEBp	M4LNdmROW09?	MlfuSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=>	Mn7KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO4OFAoRjJyMUSzPFQxRC:jPh?=
Caco-2	MUfLbY5ie2ViQYPzZZk>	NGnK[4E3NjN{IH7NJJRwKDZ\|MjFOwG0>	NWXpfZlrPCCq	NV2xc\|VHTE2VTx?=	Mn;iSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2=	M1z4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N\|g1ODxxYU6=
Caco-2	NFHsRY5McW6jc3WgRZN{[Xl?	NVXhOXlMOC5\|MU[gcm0hfG9iM{GuOkDPxE1?	Mne1OEBp	MWrEUXNQ	MnfDSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN4	NHHTS\|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|g1OCd-MkCxOFM5PDB:L3G+
HepG2	M{PieWtqdmG\|ZTDBd5NigQ>?	MV61JO69VQ>?	NGnxeJc3cA>?	MVzEUXNQ	Mo\ETY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDhZ4V1gWyjdHnvci=>	MoHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO4OFAoRjJyMUSzPFQxRC:jPh?=
HepG2	MWXLbY5ie2ViQYPzZZk>	M4LLXlUh\|ryP	M2m4elZp	MmLvSG1UVw>?	NXTrW4czUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm\|dH;u[UBpgXCncnHj[ZR6dGG2aX;u	NGLtV3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|g1OCd-MkCxOFM5PDB:L3G+
HepG2	NHPvSHBMcW6jc3WgRZN{[Xl?	MYC1JO69VQ>?	NWq4UWZ2Pmh?	NYTqT\|lTTE2VTx?=	M{\xV2lv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36=	NH\TNHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N\|g1OCd-MkCxOFM5PDB:L3G+
HepG2	NXTHWGFjU2mwYYPlJGF{e2G7	NYSxPXk2PSEQvF2=	M4ftfFZp	NE[1cWpFVVOR	NV3CXFJDUW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhUDNxSESgbIl{fG:wZTDhZ4V1gWyjdHnvci=>	M{nPbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUSzPFQxLz5{MEG0N\|g1ODxxYU6=
COLO205	M2e2OmtqdmG\|ZTDBd5NigQ>?	M1rZTFExKM7:TR?=	MWqyOEBp	MoKwSG1UVw>?	MV;Jcohq[mm2aX;uJI9nKEiGQVOxJIF{e2W\|c3XkJIF{KGmwZIXjeIlwdiCxZjDobZN1d26nIFizJIFk\XS7bHH0bY9vKHerdHigTWM2OCCxZjCyMlIh\|ryP	M3Tkb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEWxN\|c5Lz5{MES1NVM4QDxxYU6=
SCC4	MVjLbY5ie2ViQYPzZZk>	NYH2[ZRLOSEQvF2=	NWDMcW9zOjSq		NV;MfFJrUW6qaXLpeIlwdiCxZjDISGFEKGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44>	MoqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2NUKyNlUoRjJyNEWyNlI2RC:jPh?=
SCC4	M4\2XmtqdmG\|ZTDBd5NigQ>?	MVixJO69VQ>?	MX6yOIg>		MYXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCjY3X0fYxifGmxbh?=	NEXBfXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES1NlIzPSd-MkC0OVIzOjV:L3G+
SCC4	NUnpPHFiTnWwY4Tpc44hSXO\|YYm=	NVnDcm5uOSEQvF2=	NI\Sb3g2KG2rbh?=		MkfrRYdwdmm\|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?=	NHf3VHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES1NlIzPSd-MkC0OVIzOjV:L3G+
NB4	Mn\YSpVv[3Srb36gRZN{[Xl?	NETV[Ww2KM7:TR?=	M4jheVI1KGh?	MX;EUXNQ	MUPD[YxtKGO7Y3zlJIFzemW\|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn	MnTzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2OUG0OFAoRjJyNEmxOFQxRC:jPh?=
NB4	MUPLbY5ie2ViQYPzZZk>	NYnmd\|IzPSEQvF2=	NUHVd5ZHOjRiaB?=	MUHEUXNQ	MXfJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iYXPleJlt[XSnIIT1ZpVtcW5ibHX2[Yw>	NES4SFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES5NVQ1OCd-MkC0PVE1PDB:L3G+
NB4	MoX1SpVv[3Srb36gRZN{[Xl?	MnTYOUDPxE1?	MX[yOEBp	M1XpeGROW09?	NGe2OndKdmS3Y4Tpc44hd2ZicEKxW2FHOS:FSWCxJIV5eHKnc4Ppc44>	NInuV4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES5NVQ1OCd-MkC0PVE1PDB:L3G+
NB4	MVPLbY5ie2ViQYPzZZk>	MXK1JO69VQ>?	NIDKTnczPCCq	NYW4VXNPTE2VTx?=	MV\Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=>	NF22V449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MES5NVQ1OCd-MkC0PVE1PDB:L3G+
NUGC3	NGOy[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUjQb4pNT0l3ME2yMlk1KM7:TR?=	NU\6dYh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OVA6PzFpPkKwPFUxQTdzPD;hQi=>
A549	MoHLSpVv[3Srb36gRZN{[Xl?	MVy1JO69VQ>?	NF;DSm4{KGh?	NYnX[np3TE2VTx?=	M2PtZ2lv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=>	Mn;HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NUWyNFgoRjJyOEW1NlA5RC:jPh?=
HUT78	NXnoT5U6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M2Wz[FczKGh?	M2S2bWROW09?	Ml[4S2k2OD1yLkOg{txO	NUXZdZpCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4PFQzODhpPkKwPFg1OjB6PD;hQi=>
U937	NFvCTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NU\3e2lNPzJiaB?=	Mnj5SG1UVw>?	M1vQZWdKPTB;MD6zPUDPxE1?	NVLtVZg2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4PFQzODhpPkKwPFg1OjB6PD;hQi=>
A431	M2LQeWN6fG:2b4jpZ{BCe3OjeR?=		MWS3NkBp		NHn2bnlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2=	MkDiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
A549	M{eyWGN6fG:2b4jpZ{BCe3OjeR?=		NYnZTIlZPzJiaB?=		MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJI93\XKneIDy[ZN{cW6pIFjERWMhf2m2aDDJR\|UxKG:oIEGuPEDPxE1?	NXXURlFQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
CAL27	M2PxNGN6fG:2b4jpZ{BCe3OjeR?=		NVPNSWhlPzJiaB?=		NFr0S4tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW\|c3nu[{BGT0[UIIfpeIghUUN3MDDv[kA{NjJizszN	MorwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
HeLa	NH3Wcm1EgXSxdH;4bYMhSXO\|YYm=		MljxO\|IhcA>?		NFL0RndEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2=	NVrLZ5V2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
Sf21	M{W4OGtqdmG\|ZTDBd5NigQ>?		Mn2zN{Bp		NFq1O2RKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=>	M3P3eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
SKBR3	MWLDfZRwfG:6aXOgRZN{[Xl?		MkLSO\|IhcA>?		MkDmR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?=	NUHOUW85RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3OjlpPkKxNFgxPjJ7PD;hQi=>
SKOV3	NInNT29EgXSxdH;4bYMhSXO\|YYm=		MXS3NkBp		M1PaWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMV1Z\|IHPlcIx{KG:4ZYLlfJBz\XO\|aX7nJGhGWjJid3n0bEBKSzVyIH;mJFIvOiEQvF2=	MoDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
COR-L23	MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF3EPWgyOCEQvF2=	NYW5dm5XPzJiaB?=	NIG2dGJFVVOR	MkP4S2k2OD1zLkGg{txO	NVLwbYlDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
DU145	M{XObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmraNVAh\|ryP	MVi3NkBp	MUnEUXNQ	NXLI[XJ4T0l3ME2xMlA2KM7:TR?=	NW\MXHFsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
LoVo	Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4\FOVExKM7:TR?=	M2PwO\|czKGh?	NWnMe2VSTE2VTx?=	NVHJT4xmT0l3ME2xMlch\|ryP	NYrWVlZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGwPFA3PDdpPkKxNFgxPjR5PD;hQi=>
MCR5-SV2	NYj4ZYhXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXKOnFsOTBizszN	NWPufZU6PzJiaB?=	Mn3NSG1UVw>?	NW\z[pFHT0l3ME2yMlEh\|ryP	M1fmNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlQ4Lz5{MUC4NFY1PzxxYU6=
HCT116	Mlu2T4lv[XOnIFHzd4F6	NGXqenU{OCEQvF2=	MVGzNEBp	MnzySG1UVw>?	MV3Jcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W\|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
HCT116	M{P5fmtqdmG\|ZTDBd5NigQ>?	MUKzNEDPxE1?	M4jtV\|MxKGh?	M1y4U2ROW09?	NYO0W4ZSUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm\|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u	M4jqclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlQ4Lz5{MUC4NFY1PzxxYU6=
U937	M4PpdmtqdmG\|ZTDBd5NigQ>?	NEK1eZY2KM7:TR?=	NVSwOWc{OjRiaB?=	M1PHS2ROW09?	MmXaTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6\|ZnXyZZNmKGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl?	NFjXTmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5NlQ6Oid-MkGyPVI1QTJ:L3G+
U937	NXn1foxwU2mwYYPlJGF{e2G7	NIG0[oU2KM7:TR?=	M1[5fVI1KGh?	NIDsWpVFVVOR	MVHJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO\|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMOTh?	M{TjblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkmyOFkzLz5{MUK5NlQ6OjxxYU6=
U937	NGXCcXZMcW6jc3WgRZN{[Xl?	Mo\UOUDPxE1?	NUDsVG5bOjRiaB?=	MkHDSG1UVw>?	NEDxTXhKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?=	NEjNVWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUK5NlQ6Oid-MkGyPVI1QTJ:L3G+
U937	M2fYeWtqdmG\|ZTDBd5NigQ>?	NHXu[GY2KM7:TR?=	NEezVnUyPSCvaX6=	M{LoXmROW09?	M1u3dWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG\|ZTDv[kBpcXO2b37lJGg{KGGlZYT5cIF1cW:wIHzleoVt	MmS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{OUK0PVIoRjJzMkmyOFkzRC:jPh?=
A2780	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NETncVc6PiCq	MWjEUXNQ	M1;2c2lEPTB;MT62NkDPxE1?	NVjlWZJqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2N\|Q1OzBpPkKxOlM1PDNyPD;hQi=>
COLO205	Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M3ziSVk3KGh?	M4PhRmROW09?	NVrQdWluUUN3ME2yMlEzKM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ\|NESzNEc,OjF4M{S0N\|A9N2F-
Hep3B	NIHVd\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NH;pN\|E1QCCq	MVfEUXNQ	M1[2S2dKPTB;MT6yNUDPxE1?	NWj0clBWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3NVIyPDZpPkKxO\|EzOTR4PD;hQi=>
GM11272	Ml32SpVv[3Srb36gRZN{[Xl?	NHH5S5QyODBibl2=	MUW3NkBp	M{O4U2ROW09?	MVfS[YFkfGm4YYTpc44hd2ZiTXXDdFIhdXW2YX70JIV5eHKnc4Ppc44h[XRiMUCgeI8hOTByIH7N	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh2MEexOkc,OjF6NEC3NVY9N2F-
CFBE41o	MXPLbY5ie2ViQYPzZZk>	Mn3ROUDPxE1?		MU\EUXNQ	NYrVd5hxTG:5bjDy[Yd2dGG2aX;uJI9nKEiGQVO3JIF1KDBwMjD0c{A2KHWP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NEm1PEc,OjF7OES5OVg9N2F-
CFBE41o	MlTmSpVv[3Srb36gRZN{[Xl?	M1j5bVEh\|ryP	MWOyOEBp	NUGxeItpTE2VTx?=	NIXTV\|dT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC\|dYLmZYNmKGG\|IHfsfYNw\m:{bYO=	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl6NEm1PEc,OjF7OES5OVg9N2F-
DU145	MWLLbY5ie2ViQYPzZZk>	NFu4eYczNjVizszN	MkK3NlQhcA>?	NGK1NZNFVVOR	MmPrTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W\|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW\|c3nvci=>	M2K2OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mk[wNVY3Lz5{MkK2NFE3PjxxYU6=
DU145	NUjDW\|Y2U2mwYYPlJGF{e2G7	Mn3zOUDPxE1?	MnrRNlQhcA>?	MlLxSG1UVw>?	MlHDTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W\|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36=	Ml;GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkCxOlYoRjJ{Mk[wNVY3RC:jPh?=
DU145	M4TGSGtqdmG\|ZTDBd5NigQ>?	M{nrNlUh\|ryP	MmTFNlQhcA>?	MmX1SG1UVw>?	MYjJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO\|ZXSgZZMhcGm\|dH;u[UBJOyCqeYDldoFk\XS7bHH0bY9v	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ4MEG2Okc,OjJ{NkCxOlY9N2F-
786-0	NIC3TWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWO2MlIh\|ryP	NULUOHdTPzJiaB?=	NF3TRnZFVVOR	NFHSdI5IUTVyPUOuNkDPxE1?	NVntdZh3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
A498	MkC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkfVOk4zKM7:TR?=	MU[3NkBp	MYnEUXNQ	NFO2UpZIUTVyPUGuOkDPxE1?	NEW5RZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
A549/ATCC	M4XEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoPJOk4zKM7:TR?=	M2jaSVczKGh?	MYLEUXNQ	M1G3eGdKPTB;MT62JO69VQ>?	NUizV\|VTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
ACHN	NVe1fIVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPrVmU3NjJizszN	MkHPO\|IhcA>?	MV7EUXNQ	NXHyZVI3T0l3ME2xMlMh\|ryP	NFS2NpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
BT549	NVvtXXZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LG[lYvOiEQvF2=	MUS3NkBp	NXrNbZMzTE2VTx?=	NGnCN5RIUTVyPUGuN{DPxE1?	Mlu1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
EKVX	NFHyT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPGfmtIPi5{IN88US=>	MmTYO\|IhcA>?	NFH1NHVFVVOR	MlrZS2k2OD1zLkOg{txO	M4P2OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
HCT15	NVfhOWQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfpOk4zKM7:TR?=	MmDQO\|IhcA>?	MWXEUXNQ	NX71XYdpT0l3ME2yMlUh\|ryP	Ml\DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
HOP92	Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3rKblYvOiEQvF2=	M3P1ZVczKGh?	MW\EUXNQ	NIXhUHlIUTVyPUSg{txO	MmLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
IGROV1	M3rFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIrWVYc3NjJizszN	M2\GN\|czKGh?	M3L0OWROW09?	MUfHTVUxRTFwMzFOwG0>	M3X0W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
LOXIMVI	MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVW2MlIh\|ryP	NXH3O5dyPzJiaB?=	Mo\ESG1UVw>?	Mmn6S2k2OD1zIN88US=>	M3LlNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
M14	NYDzdmdyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2f1N\|YvOiEQvF2=	NWLCUm56PzJiaB?=	MoPxSG1UVw>?	NUHw[\|FqT0l3ME2xMlMh\|ryP	MoDiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
MALME-3M	NFnnfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2Xa[VYvOiEQvF2=	MX23NkBp	NF;uPXRFVVOR	NITGTlJIUTVyPUCuN\|Ih\|ryP	NGXNbpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
MCF10A	Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHsZoZIPi5{IN88US=>	Mo\rOFghcA>?	NVKx[WYzTE2VTx?=	MmT0S2k2OD17Lk[g{txO	NEnjZWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
MDA-MB-435	NXrqRmY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWT2VYFlPi5{IN88US=>	Mn:xO\|IhcA>?	NH\WeZBFVVOR	M2fFdWdKPTB;MD61JO69VQ>?	NV;sc3JERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
MDA-MB-468	NEjCeoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{jNZlYvOiEQvF2=	NYL5S2dMPzJiaB?=	NETmOY5FVVOR	M4XvSWdKPTB;MD62N{DPxE1?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
MOLT4	M{nNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1PQeVYvOiEQvF2=	MYS3NkBp	MVzEUXNQ	M3u4XGdKPTB;MD60JO69VQ>?	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
NCI-ADR-RES	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIrrd5E3NjJizszN	M3;IZlczKGh?	M2HSXGROW09?	MWPHTVUxRTBwMU[g{txO	NWLCe2JWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
NCI-H23	M4LXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1nXcFYvOiEQvF2=	NFe3NlU4OiCq	MX\EUXNQ	NWf3e4RlT0l3ME2xJO69VQ>?	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
NCI-H322M	M{nBPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHLe\|hPPi5{IN88US=>	NFvoV5E4OiCq	NVvFcpBHTE2VTx?=	NET0XFFIUTVyPUCuO\|kh\|ryP	NYLZd2pVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
NCI-H460	NHmyfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXS2MlIh\|ryP	NITCOJc4OiCq	MXPEUXNQ	MX3HTVUxRTBwN{mg{txO	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
NCI-H522	NYfJZXh7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NW\sfFN2Pi5{IN88US=>	Ml:2O\|IhcA>?	MnviSG1UVw>?	MYfHTVUxRTBwNTFOwG0>	NFHTbI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
OVCAR3	M2qwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrMXlc3NjJizszN	M4XEb\|czKGh?	M3;3NWROW09?	MXjHTVUxRTFwMzFOwG0>	MmDZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
OVCAR4	M3T6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTISoc3NjJizszN	M4DV[\|czKGh?	NWjqPFVCTE2VTx?=	NWj5O\|VxT0l3ME20JO69VQ>?	M2H2R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
OVCAR5	MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYO2MlIh\|ryP	NXHmNWt4PzJiaB?=	NHLHcodFVVOR	M1nGbWdKPTB;MD63PUDPxE1?	NH3PfXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
OVCAR8	NGfQd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWPUXohzPi5{IN88US=>	NHOw[YU4OiCq	NVzFS5lKTE2VTx?=	NXr3d3ZoT0l3ME2wMlUh\|ryP	Ml;XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
RXF393	NIjwV\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHEZ29HPi5{IN88US=>	NIHHUoc4OiCq	M2L0fGROW09?	NUDvfFh[T0l3ME2xMlMh\|ryP	NYm1VGU6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
SF268	NV33XJpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYi2MlIh\|ryP	NFT5eXo4OiCq	M2m3OWROW09?	NXnUPXBFT0l3ME2xMlYh\|ryP	MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
SF295	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoW2Ok4zKM7:TR?=	M1zmOVczKGh?	NILUOlRFVVOR	MUnHTVUxRTFwNjFOwG0>	NH;ie449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
SF539	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFjofmI3NjJizszN	MoTyO\|IhcA>?	NFr0SlZFVVOR	M3HGdmdKPTB;MjFOwG0>	NHPpdVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
SK-MEL-2	NYPI[oFPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\BOJZlPi5{IN88US=>	M2XtZVczKGh?	MXjEUXNQ	NWnzWGtlT0l3ME2xMlMh\|ryP	M4m4XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
SK-MEL-28	MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPzOk4zKM7:TR?=	M4fle\|czKGh?	NF3FZ5dFVVOR	NV3ZcphCT0l3ME2xJO69VQ>?	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
SK-MEL-5	NFvxUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX7RZnI3Pi5{IN88US=>	MoLxO\|IhcA>?	NVPYfoo6TE2VTx?=	NYT0O4V[T0l3ME2wMlY{KM7:TR?=	M3TVXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO1OlY6Lz5{MkSzOVY3QTxxYU6=
SKOV3	M3LseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWTLXmtmPi5{IN88US=>	MVK3NkBp	MmLHSG1UVw>?	MVXHTVUxRTFizszN	MkD0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2M{W2OlkoRjJ{NEO1OlY6RC:jPh?=
SN12C	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3q5TVYvOiEQvF2=	M2nJRlczKGh?	MoHoSG1UVw>?	MmTHS2k2OD1{IN88US=>	NIDrd3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
SNB19	M4jvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmW0Ok4zKM7:TR?=	M4n0SlczKGh?	NXHy[FhXTE2VTx?=	NVzRXI86T0l3ME2wMlY{KM7:TR?=	NIHkTnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
SNB75	MnTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{nrOlYvOiEQvF2=	NVLncJI5PzJiaB?=	Mlz2SG1UVw>?	MoD6S2k2OD1yLke5JO69VQ>?	NGLjUIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
SR	NUL6e\|A{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkDhOk4zKM7:TR?=	MlHUO\|IhcA>?	NVnDemc3TE2VTx?=	NUDqeZByT0l3ME2wMlQh\|ryP	NGnjZ2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
T47D	MoX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFHCWnE3NjJizszN	MWO3NkBp	M1fHfWROW09?	M2fpdWdKPTB;MD61JO69VQ>?	NV3MV2RqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
TK10	NEnIWFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXS2MlIh\|ryP	MlvUO\|IhcA>?	NFXBZVdFVVOR	M4\qSGdKPTB;MD62N{DPxE1?	NFHCSpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSzOVY3QSd-MkK0N\|U3Pjl:L3G+
UACC257	M2HaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\Zd3E1Pi5{IN88US=>	MXe3NkBp	NWr0OGxCTE2VTx?=	M2\HUGdKPTB;MD61JO69VQ>?	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
UACC62	NH\LTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4KzV\|YvOiEQvF2=	MUC3NkBp	M2frT2ROW09?	NWjSWVZCT0l3ME2wMlQh\|ryP	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR\|NU[2PUc,OjJ2M{W2Olk9N2F-
UO31	MlX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVW2MlIh\|ryP	NEj6SpM4OiCq	MlTaSG1UVw>?	M2q0[GdKPTB;MD61JO69VQ>?	NVHTfmt{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0N\|U3PjlpPkKyOFM2PjZ7PD;hQi=>
Hep3B	Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		Mn[1OFghcA>?	MW\EUXNQ	NHnNRpRIUTVyPUCuOlkh\|ryP	M4W3R\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEO5PFY{Lz5{MkSzPVg3OzxxYU6=
BE(2)-C	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M4nhe\|czKGh?	NUCwW5h6TE2VTx?=	MnLkTWM4OD1{IN88US=>	NF3nNYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzNlMyPid-MkK5N\|I{OTZ:L3G+
Bel7402	NHfSNlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NGjXVlQ4OiCq	M4faVWROW09?	MnLiS2k6OD1zNzFOwG0>	NYXQSFdqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
Bel7404	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NEfSdlM4OiCq	NELHVoxFVVOR	NEjjOldIUTlyPUG4JO69VQ>?	NEHGboo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVM4Pid-MkOwOlE{PzZ:L3G+
BGC823	M1rVWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NE[0XY84OiCq	M3S5OmROW09?	NUHte\|RyT0l7ME23MlUh\|ryP	NVzwXHpqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
MGC803	MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NGnTSm84OiCq	M4jm[2ROW09?	M33hR2dKQTB;MUCuPEDPxE1?	M{PVd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|ME[xN\|c3Lz5{M{C2NVM4PjxxYU6=
SGC7901	Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MkG3O\|IhcA>?	NHXGUHhFVVOR	MVXHTVkxRTlwNDFOwG0>	NHTZdmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C2NVM4Pid-MkOwOlE{PzZ:L3G+
SKHEP1	M{TkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NYPRT\|BHPzJiaB?=	MWXEUXNQ	NXO3eppwT0l7ME2xO{DPxE1?	M4XCUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|ME[xN\|c3Lz5{M{C2NVM4PjxxYU6=
SMMC7721	Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MX:3NkBp	NE[1NplFVVOR	NXvobII{T0l7ME2yNEDPxE1?	NXzxTmhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwOlE{PzZpPkKzNFYyOzd4PD;hQi=>
NUGC3	NYHS[JNvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{SwdVExKM7:TR?=			MV\HTV0zNjl2IN88US=>	M2\4OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MU[zN\|MzLz5{M{G2N\|M{OjxxYU6=
A2780 CisR	MW\LbY5ie2ViQYPzZZk>		M{D0UlE5KGh?		NWrxTlZuUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?=	NFzjUHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
CAL27 sens	MkfGT4lv[XOnIFHzd4F6		MXqxPEBp		NX;5cVZmUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?=	M4LN[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
CAL27 CisR	M{e1eWtqdmG\|ZTDBd5NigQ>?		NGOxfpMyQCCq		M2XBWGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1?	M2ThRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MkWyOlA{Lz5{M{K1NlYxOzxxYU6=
KYSE-510 CisR	M3TTeWtqdmG\|ZTDBd5NigQ>?		NEPvb5gyQCCq		Mn\1TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkW5JO69VQ>?	NWjtc2l3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOVI3ODNpPkKzNlUzPjB\|PD;hQi=>
KYSE-510 sens	MoLzT4lv[XOnIFHzd4F6		NV3aXFlzOThiaB?=		MUXJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0>	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ3Mk[wN{c,OjN{NUK2NFM9N2F-
MDA-MB-231 sens	NFHRRYxMcW6jc3WgRZN{[Xl?		NFraXmUyQCCq		MmTYTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>?	MnHUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{NUK2NFMoRjJ\|MkWyOlA{RC:jPh?=
MDA-MB-231 CisR	NFPIZYlMcW6jc3WgRZN{[Xl?		MlLJNVghcA>?		M37pVWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1?	NH3LdoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K1NlYxOyd-MkOyOVI3ODN:L3G+
ES2	NFXjXmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NHW0cFk1QCCq	NFzoWW5FVVOR	MYrJR\|UxRTF{Lkeg{txO	MoHhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUO0OFkoRjJ\|NEmzOFQ6RC:jPh?=
MDA-MB-231	MlHyT4lv[XOnIFHzd4F6	MWixNEDPxE1?	MmS2N\|AhdWmw	NHTRS2dFVVOR	MlvPTY5pcWKrdHnvckBw\iCKRFHDNoE>	MojEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUO0OFkoRjJ\|NEmzOFQ6RC:jPh?=
MDA-MB-231	NUPuc5JoU2mwYYPlJGF{e2G7	NFrBOHIyKM7:TR?=	NX3VNZRQOjRiaB?=	NFGxXIxFVVOR	MlTzTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?=	NFTZRYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5N\|Q1QSd-MkO0PVM1PDl:L3G+
HS68	NHPnbG1EgXSxdH;4bYMhSXO\|YYm=	MojkNVAh\|ryP	M3PSOVczKGh?	MorVSG1UVw>?	MWXJR\|UxRTRwNjFOwG0>	MkjuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3N{C1OFIoRjJ\|NUewOVQzRC:jPh?=
MEF	M13UV2N6fG:2b4jpZ{BCe3OjeR?=	MUmxNEDPxE1?	MXe3NkBp	MW\EUXNQ	MWLJR\|UxRTRwNDFOwG0>	M{KycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NUewOVQzLz5{M{W3NFU1OjxxYU6=
BGC823	NHSxUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=			NXzjTop2TE2VTx?=	NYfCdmN6T0l3ME2zMlA6KM7:TR?=	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMUewOkc,OjN4MEG3NFY9N2F-
High5	M3zZN2tqdmG\|ZTDBd5NigQ>?		NXj6dItrOjRiaB?=		NWPIO4g5UW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkWyN{c,OjN4MEK1NlM9N2F-
High5	M{jiR2tqdmG\|ZTDBd5NigQ>?		M3jvXFI1KGh?		MV;Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOxJJdqfGhiSVO1NEBw\iByLkGyJO69VQ>?	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZyMkWyN{c,OjN4MEK1NlM9N2F-
High5	MoXYT4lv[XOnIFHzd4F6		M2X4SVI1KGh?		NYPIPJFkUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOyC5aYToJGlEPTBib3[gNE4yPyEQvF2=	Mm\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MEK1NlMoRjJ\|NkCyOVI{RC:jPh?=
A549	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?			MkLDSG1UVw>?	NVfvSJFLUUN3ME2xMlA4QSEQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ2NEKxNEc,OjN4NESyNVA9N2F-
HCT116	NX3DeVM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=			MVTEUXNQ	MkTPTWM2OD1yLke1O{DPxE1?	Ml2yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVAoRjJ\|NkS0NlExRC:jPh?=
K562	M{\2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7			MlHPSG1UVw>?	M2[3fGlEPTB;MD62OFUh\|ryP	Mmq4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NESyNVAoRjJ\|NkS0NlExRC:jPh?=
GBC-SD	NFvJTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlLvOUDPxE1?	NV\MTolbPzJiaB?=	NInD[lBFVVOR	M4XxSGlEPTB;MUSuPEDPxE1?	Ml7aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5MEeyOlAoRjJ\|N{C3NlYxRC:jPh?=
HGC27	NVTsPVlFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1;zelUh\|ryP	MUi3NkBp	NHjpc5lFVVOR	MmS2TWM2OD13LkSg{txO	NWj0[GRIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3NFczPjBpPkKzO\|A4OjZyPD;hQi=>
HL60	MmfPT4lv[XOnIFHzd4F6	NETwT4c2KM7:TR?=	NVn4UlZzOjRiaB?=	NH7zdodFVVOR	NYjTOJB1UW6qaXLpeIlwdiCxZjDISGFE	NH\ldHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewO\|I3OCd-MkO3NFczPjB:L3G+
Vero	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MVO3NkBp	NGnPfW5FVVOR	NFfl[lNKSzVyPUCuPUDPxE1?	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd6NkS1Nkc,OjN5OE[0OVI9N2F-
NCI60	NWHCN3BpS3m2b4TvfIlkKEG\|c3H5		NID0VHQ1QCCq	MnXVSG1UVw>?	NGTt[pFIUT1yLkWzJO69VQ>?	Mn;UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUWzNlcoRjJ2MEG1N\|I4RC:jPh?=
SW620	NFzHcVNEgXSxdH;4bYMhSXO\|YYm=		MkftOFghcA>?	MX\EUXNQ	MXnHTV0xNjV2IN88US=>	MnfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMUWzNlcoRjJ2MEG1N\|I4RC:jPh?=
U251	MoHjR5l1d3SxeHnjJGF{e2G7		MoXPOFghcA>?	MmG3SG1UVw>?	M3S3ZWdKRTFwNUOg{txO	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
KM12	MXXDfZRwfG:6aXOgRZN{[Xl?		M{HDdFQ5KGh?	NYDRPIZqTE2VTx?=	M4T5TGdKRTFwOEig{txO	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDBzNUOyO{c,OjRyMUWzNlc9N2F-
Hs578T	NXGy[JFzS3m2b4TvfIlkKEG\|c3H5		NWHLTFU{PDhiaB?=	NVrHcW4{TE2VTx?=	M{fydmdKRTRwOEOg{txO	NUm1WW4{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNVU{OjdpPkK0NFE2OzJ5PD;hQi=>
MDA-MB-231	M{nt[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1LUdlQ5KGh?		MoHQTWM2OD1yLkG2JO69VQ>?	MlfIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUWwNVYoRjJ2MEm1NFE3RC:jPh?=
MCF7	MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MVq0PEBp		MmLiS2k:OC52NTFOwG0>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFzOUW1OUc,OjRzMUm1OVU9N2F-
MDA-MB-435	NID4WJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NEHVVnA1QCCq		NYX0fGZuT0l;MD64PEDPxE1?	M{XUXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUG5OVU2Lz5{NEGxPVU2PTxxYU6=
AsPC1	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn7oN\|Ah\|ryP	M3yzSlQ5KGh?	NUD5UYZzTE2VTx?=	M1zi[mlEPTB;Mz62OkDPxE1?	M3HWdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUi1N\|c5Lz5{NEG4OVM4QDxxYU6=
Jurkat E6.1	NYTndYpUU2mwYYPlJGF{e2G7		MmO0NkBp	MoG2SG1UVw>?	MmezTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1?	NV;QR\|VmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyOlE5PjJpPkK0NlYyQDZ{PD;hQi=>
KG1	M3jEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUCwSFBiPDhiaB?=		M1vGeWlEPTB;MT6xOUDPxE1?	M4rJ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUK1NFA{Lz5{NEWyOVAxOzxxYU6=
HEL	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M{\SNVQ5KGh?	NVzKZVBvTE2VTx?=	NFXQUG1KSzVyPUCuOFkh\|ryP	M1XuNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2Nkm0NFU2Lz5{NE[5OFA2PTxxYU6=
HSC3	M3q4b2N6fG:2b4jpZ{BCe3OjeR?=		M{TpVVEzKGh?	MorySG1UVw>?	NYDUOlF7UUN3ME2wMlcyKM7:TR?=	NEnEPVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
HT-29	NEOyNXFEgXSxdH;4bYMhSXO\|YYm=		NHn5e\|UyOiCq	NVj1T3FmTE2VTx?=	M4PXWmlEPTB;MD63NkDPxE1?	M1Xl[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{[2OVYxLz5{NEe2OlU3ODxxYU6=
KB	M36yN2N6fG:2b4jpZ{BCe3OjeR?=		MXyxNkBp	NVq5XXF6TE2VTx?=	MWTJR\|UxRTBwN{Wg{txO	NY\5[JJIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3OlY2PjBpPkK0O\|Y3PTZyPD;hQi=>
H460	NWXjN2pPS3m2b4TvfIlkKEG\|c3H5		MXSxNkBp	MVPEUXNQ	NYLhNJVOUUN3ME2wMlgzKM7:TR?=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
MONE1	NIXi[\|FEgXSxdH;4bYMhSXO\|YYm=		MU[xNkBp	NHr2SGtFVVOR	M1\BbmlEPTB;MT6xPEDPxE1?	Ml\nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
MKN45	MUnDfZRwfG:6aXOgRZN{[Xl?		MXyxNkBp	MVjEUXNQ	MV;JR\|UxRTFwMkWg{txO	NIXBXFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe2OlU3OCd-MkS3OlY2PjB:L3G+
TSGH	MoDaR5l1d3SxeHnjJGF{e2G7		MXyxNkBp	MknMSG1UVw>?	NGXFcJJKSzVyPUKuNFkh\|ryP	Ml76QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5Nk[1OlAoRjJ2N{[2OVYxRC:jPh?=
HL60	M4Lsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M33sbVczKGh?	NXXHVnpFTE2VTx?=	NYWxV3I6T0l3ME2wMlk{KM7:TR?=	NVfjTXd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA2ODBpPkK0PVAxPTByPD;hQi=>
HEK293	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NU\pWHhLPzJiaB?=	NEX0cWpFVVOR	NI\Od2ZIUTVyPUGzJO69VQ>?	M4rLdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwOVAxLz5{NEmwNFUxODxxYU6=
Jurkat	NYCzdIR{S3m2b4TvfIlkKEG\|c3H5	NUPjS2xZOTByIN88US=>	MYq3NkBp		Mn7tS2k2OD1yLkmg{txO	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEe0N{c,OjR7MEC3OFM9N2F-
GM15850	M1f1WmtqdmG\|ZTDBd5NigQ>?	MnjnNk42KM7:TR?=	MlLKPVYhcA>?	M3TTd2ROW09?	NXHXem9Z\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDF2IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m	NV\YW\|hRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850	NWO2O3AzU2mwYYPlJGF{e2G7	MWGyMlUh\|ryP	NUjwdZhuQTZiaB?=	NGXtZXFFVVOR	M3HFc4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG\|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA2KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l	NVTPVpRHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850	M1nycmtqdmG\|ZTDBd5NigQ>?	MU[yMlUh\|ryP	MojtPVYhcA>?	M1TLT2ROW09?	NUGxTmo1\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDRibInzbY5mKDF{IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m	M1XaOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN\|Y4Lz5zNkmyNVM3PzxxYU6=
GM15850	MXLLbY5ie2ViQYPzZZk>	NUDsXJZ7Oi53IN88US=>	NUe1UWx[QTZiaB?=	M4TSU2ROW09?	NGPFPYpld2W\|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm\|dH;u[UBJOyCueYPpcoUhQSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=>	MkfmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ7MkGzOlcoRjF4OUKxN\|Y4RC:jPh?=
GM15850	NIP5eYNMcW6jc3WgRZN{[Xl?	MV[yMlUh\|ryP	M136W\|k3KGh?	NGDUWmdFVVOR	MnrW[I9meyCwb4SgbY5pcWKrdDDISGFEKGG\|c3Xzd4VlKGG\|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm\|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW=	NYfBPJpyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5NlE{PjdpPkG2PVIyOzZ5PD;hQi=>
GM15850	MoHKT4lv[XOnIFHzd4F6	MnHyNk42KM7:TR?=	NHO5fnM6PiCq	NIjUN2NFVVOR	MV3kc4V{KG6xdDDpcohq[mm2IFjERWMh[XO\|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW=	NEPyVZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkmyNVM3Pyd-MU[5NlE{Pjd:L3G+
GM15850	Mo\qSpVv[3Srb36gRZN{[Xl?	MXy1JO69VQ>?	M3XLXVEzKGh?	NInSZ\|RFVVOR	MUfoZZMhdm9iZX\m[YN1KG:wIF\YUkBuWk6DIHX4dJJme3Orb36=	M4\US\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUKxN\|Y4Lz5zNkmyNVM3PzxxYU6=
U937	M3LHdmtqdmG\|ZTDBd5NigQ>?	NWfCbm5pPSEQvF2=	MnL5NlQhcA>?	MlfiSG1UVw>?	NFrm[3Fp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36=	NEjKS5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{S0O\|c2OCd-MUe0OFc4PTB:L3G+
U937	Mn[wT4lv[XOnIFHzd4F6	MWOxJO69VQ>?	NXnvdIhVOjRiaB?=	MXHEUXNQ	M4\FVohieyCwbzDl[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?=	M3\BcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NES3O\|UxLz5zN{S0O\|c2ODxxYU6=
PANC1	NVTHTWdHTnWwY4Tpc44hSXO\|YYm=	Mn;INUDPxE1?	MW[yOEBp		MoLV[I9meyCwb4SgbY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36=	M2TQdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NUi4O\|Q1Lz5zN{W4PFc1PDxxYU6=
PANC1	NWfCOFhSTnWwY4Tpc44hSXO\|YYm=	MXuxJO69VQ>?	NFja[5M1QCBiaB?=		MV3kc4V{KG6xdDDpcoNz\WG\|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?=	NELLUFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{W4PFc1PCd-MUe1PFg4PDR:L3G+
Caco-2	M{\zT2Z2dmO2aX;uJGF{e2G7	NEn4fmw2KM7:TR?=	MkfqNlQhcA>?	MXTEUXNQ	M4HPcYRw\XNibn;0JIlv\HWlZTDQNlFYSUZzIHflcoUh\XiycnXzd4lwdg>?	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF2M{i0NEc,OjBzNEO4OFA9N2F-
SCC4	MVrGeY5kfGmxbjDBd5NigQ>?	NXXGTYZOOSEQvF2=	M{jYOFExKG2rbh?=	MmHZSG1UVw>?	NXKx[4U5cGG\|IH7vJIFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36=	M1HYTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEWyNlI2Lz5{MES1NlIzPTxxYU6=
A549	MV;GeY5kfGmxbjDBd5NigQ>?	MoPWOUDPxE1?	NXPDbWt7OyCq	MVzEUXNQ	MnfH[I9meyCwb4SgbY5lfWOnIHH1eI9xcGGpeTDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh3NUKwPEc,OjB6NUWyNFg9N2F-
HCT116	NInNWlNMcW6jc3WgRZN{[Xl?	M1O2VlAvOyEQvF2=	MVuzNEBp	MnTLSG1UVw>?	MmKz[I9meyCwb4SgbY5pcWKrdDDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm\|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[0O{c,OjFyOEC2OFc9N2F-
HepG2	NHfsOo5HfW6ldHnvckBCe3OjeR?=	MXuxNEDPxE1?	M3LNUVI1KGh?	NWH6fpZsTE2VTx?=	M1W4UoRw\XNibn;0JIlv\HWlZTDhdI9xfG:\|aYOgZZN{\XO\|ZXSgZZMhcHmyZYLhZ4V1gWyjdHnvckBw\iCyNUO=	NYX2dYJnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OFg2QDJpPkKxOVQ5PTh{PD;hQi=>
GM11272	NG\Vd4NHfW6ldHnvckBCe3OjeR?=	NG[5O2gxNjFizszN	MXS3NkBp	MXXEUXNQ	MYHkc4V{KG6xdDDy[YFkfGm4YYTlJG1mS3B{IH31eIFvfCCneIDy[ZN{cW:w	MoX1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6NEC3NVYoRjJzOESwO\|E3RC:jPh?=
MDA-MB-231	MojqT4lv[XOnIFHzd4F6	MmXpNVAh\|ryP	NXHUUllbPSCvaX6=	Mkm1SG1UVw>?	MYXkc4V{KG6xdDDpcohq[mm2IFjERWMz[Q>?	Mnm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2OUO0OFkoRjJ\|NEmzOFQ6RC:jPh?=
MDA-MB-231	M1fnb2tqdmG\|ZTDBd5NigQ>?	MUGxJO69VQ>?	MljsNlQhcA>?	M1:3eGROW09?	MoDG[I9meyCwb4SgbY5pcWKrdDDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=>	M1;ScVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEmzOFQ6Lz5{M{S5N\|Q1QTxxYU6=
K562	MorjT4lv[XOnIFHzd4F6				NYHxfZNi\G:nczDuc5QhcW6qaXLpeEBJTEGF	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV7MUGxNUc,OjN3OUGxNVE9N2F-
Jurkat	MlnDR5l1d3SxeHnjJGF{e2G7	M{CyWlIxKM7:TR?=	MYe3NkBp	MUfEUXNQ	MXvuc{BkgXSxdH;4bYNqfHliYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36=	NXSxR2FMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNFQ{PDhpPkK0N\|A1OzR6PD;hQi=>
HCT116	MnzURZBweHSxc3nzJGF{e2G7	Mmj1N{DPxE1?	M2HlNlI1KGh?	MXPEUXNQ	NWH1NHZJ\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOVMheHKxdHXpckBt\X[nbB?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd4NkW2NEc,OjR5Nk[1OlA9N2F-
KASUMI-1	NEXibFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV;xUIlLUUN3ME25PU4yPyCwTR?=	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
KARPAS-45	NV7yVFVwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{W5[mlEPTB;MUezMlg6KG6P	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
BHT-101	NFfDNXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmjoTWM2OD1{NESuNVghdk1?	M{PGbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
H9	MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3PK[WlEPTB;MkW1MlA1KG6P	NV;mW3FKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
PA-1	M{\1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGHZZZFKSzVyPUK4Ok4zPiCwTR?=	M2\mbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
NEC8	MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\SVGlEPTB;Mki5MlM5KG6P	NIO3W449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6QC9pPmPBUmdGWjxxYU6=
MHH-PREB-1	NWLMPYhUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXn3b2NuUUN3ME2yPVQvPTNibl2=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
NB7	MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3S3N2lEPTB;M{S1Mlc1KG6P	MljjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
A3-KAW	Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYCzXosyUUN3ME20NFAvPTlibl2=	MmjKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
NB69	M3XseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFy2eYtKSzVyPUSxNU44OSCwTR?=	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
EoL-1-cell	NFP3T3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NULFb5d{UUN3ME20OVQzPSCwTR?=	M4[0VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
CHP-212	NIrO[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NULsTFlVUUN3ME20OVcvPTNibl2=	NYrLd2pSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
C2BBe1	NFj0eFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3POT2lEPTB;NEeyMlE6KG6P	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
697	MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mnn0TWM2OD12N{OuOFEhdk1?	NG\NXm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6QC9pPmPBUmdGWjxxYU6=
BCPAP	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2fN[2lEPTB;NUCxMlQzKG6P	Mnv4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
L-363	MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV7j[WhLUUN3ME21NFMvOSCwTR?=	NV3TNVdCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
ES8	MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{jqXGlEPTB;NUKzMlU{KG6P	MnzRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
BE-13	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH3j[GlKSzVyPUWyOk46PiCwTR?=	MnnQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
CTB-1	M4[5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn7ITWM2OD13M{euPVIhdk1?	M1\sdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
HD-MY-Z	NGjM[\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEOyfHVKSzVyPUWzPE4yOyCwTR?=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
NKM-1	NH3we5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF;wfWtKSzVyPUW0OE4zPyCwTR?=	NInnfm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6QC9pPmPBUmdGWjxxYU6=
NCI-H720	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWXk[\|Z2UUN3ME21OlAvOThibl2=	MkD2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
KY821	MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVrBV3JwUUN3ME21OlMvOjVibl2=	NUnzZ25DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
OVCAR-5	M4LBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYjJR\|UxRTV5Nj6xNUBvVQ>?	Mn3hQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
CTV-1	NHjJVndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3P2W2lEPTB;NUixMlU3KG6P	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
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HEC-1	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mmf5TWM2OD1zLkm1N\|Yh\|ryP	MlnnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
LB2241-RCC	M2rNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFnXd5pKSzVyPUGuPVgzOzFizszN	NEHDfJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6QC9pPmPBUmdGWjxxYU6=
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LU-135	NIPPSHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnXaTWM2OD1zOT6yOlM3KM7:TR?=	MkHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
NCI-H2029	MnXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlHkTWM2OD1zOT62NFIyKM7:TR?=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
HT-1197	NWWye4xQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnLRTWM2OD1zOT65NlI4KM7:TR?=	NYrmU2M4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
IGR-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mo\MTWM2OD1{MD6zNVE4KM7:TR?=	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
U-87-MG	NVPu[oJZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{TJRmlEPTB;MkCuOlQyOyEQvF2=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
NCI-H1304	NX[4d2I4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{ToW2lEPTB;MkCuO\|UxOSEQvF2=	NFLYcGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6QC9pPmPBUmdGWjxxYU6=
RCC10RGB	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlH5TWM2OD1{MT6yPFI6KM7:TR?=	NXvjTVZtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
NCI-H520	MmHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF33SHdKSzVyPUKyMlc3OTFizszN	NVTCOYd5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
SK-LU-1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2mxZWlEPTB;MkOuNFcyQCEQvF2=	Ml2wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
UACC-893	NXOzd5lzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{LrTWlEPTB;MkOuNVA{QCEQvF2=	NUe2VoJmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQThxJ{7TRW5ITVJ:L3G+
NCI-H2347	NGfudldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYrJR\|UxRTJ\|LkK2O\|Qh\|ryP	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
U-118-MG	NIS1[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTJ\|LkeyNVch\|ryP	Mni3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
NCI-H596	NXHPW\|VFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MY\JR\|UxRTJ\|LkmwOVUh\|ryP	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
MZ1-PC	M4j1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTJ2Lk[3OVkh\|ryP	MoC2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
SW1417	M4rGN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHXyXIVKSzVyPUK1MlI1QThizszN	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
NCI-H82	NV\yUndKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2PvcGlEPTB;Mk[uOFI5QCEQvF2=	Ml71QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
COLO-678	Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHXybohKSzVyPUK3MlQ6OTlizszN	MnfLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
KURAMOCHI	NWXiZ4R[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGWwZm1KSzVyPUK4MlEzPiEQvF2=	M4rKT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
NCI-H1650	NUe5N49lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXWyT3lWUUN3ME2zNE4yQTJ2IN88US=>	MnPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
HCC1954	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{nRVWlEPTB;M{GuN\|Y3PiEQvF2=	M1r4V\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
GAK	NVPDemdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWjJeoE6UUN3ME2zNk4zPjF4IN88US=>	MkS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
YAPC	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX31UHhnUUN3ME2zN{44PjR6IN88US=>	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
NCI-H2228	NFu1fJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUfJR\|UxRTN2LkO2NFUh\|ryP	MnPuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
VMRC-RCZ	M1TrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mm\KTWM2OD1\|Nj6zNFIzKM7:TR?=	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
NMC-G1	NXPCUHpbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnexTWM2OD1\|Nz6wOVI6KM7:TR?=	M4rKOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
D-336MG	M{nuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4fKfGlEPTB;NEGuPFQ1OiEQvF2=	MlTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
UACC-62	M2XBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVjJR\|UxRTR{LkW1NFUh\|ryP	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?
C-33-A	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnHQTWM2OD12NT6zNlU3KM7:TR?=	NHvMS4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw6QC9pPmPBUmdGWjxxYU6=
HCC1937	NXHlZmNPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MljUTWM2OD12Nz6xPVU5KM7:TR?=	M2fpVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
HDLM-2	M3LEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIPBcFZKSzVyPUS3MlIzQDdizszN	MoHNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
NCI-H727	M2C2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1ruVWlEPTB;NEeuNlQ2OSEQvF2=	M1P0e\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFk5Nyd-U1HOS2VTRC:jPh?=
NY	MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVnJR\|UxRTR7LkO5NFgh\|ryP	MnXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPVgwLz6VQV7HSXI9N2F-
NCI-H2291	NH7temJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmT3TWM2OD12OT64N\|AyKM7:TR?=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly5PE8oRlODTlfFVlww[T5?

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Ac-Histone H4 / Ac-Histone H3; PubMed: 21598070 J Neurooncol D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. phospho-CDK1; PubMed: 21598070 Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. phospho-Cdc25c / Cdc25c; PubMed: 21598070 J Neurooncol Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM). Cyclin B1; PubMed: 21598070 J Neurooncol Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h. c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; PubMed: 19440035 Cancer Biol Ther Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control. p-eIF2α / ATF4 / CHOP ; PubMed: 20072656 Neoplasia Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure. p21; PubMed: 21598070 J Neurooncol To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.	21598070 19440035 20072656
Immunofluorescence	HDAC1 / CK19; PubMed: 29917299 Cancer Sci Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment. Nrf2; PubMed: 20566897 Blood Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat. α-SMA; PubMed: 26330748 Mol Vis Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm. Ac-STAT3 / IGF2; PubMed: 27086926 Oncogene Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.	29917299 20566897 26330748 27086926
Growth inhibition assay	Cell apoptosis; PubMed: 19440035 Cancer Biol Ther Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE) Cell viability; PubMed: 27086926 Oncogene The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).	19440035 27086926
ELISA	IGF2; PubMed: 27086926 Oncogene Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. IL-13 / IL-10 / IL-5; PubMed: 18541724 Blood Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM). M-CSF; PubMed: 23042302 Carcinogenesis Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF secretion. P < 0.05 and P < 0.001 versus control treatment. MMP-9; PubMed: 23042302 Carcinogenesis Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. P < 0.05 and **P < 0.001 versus control treatment.	27086926 18541724 23042302

In vivo

Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. ^[2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. ^[5]

Protocol

Kinase Assay: ^[1]	- Collapse Immunoprecipitation-HDAC assays: The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an ³H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [³H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research: ^[2]	- Collapse Cell lines: LNCaP, PC-3, and TSU-Pr1 Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM Incubation Time: 1, 2, 3 and 4 days Method: Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion. (Only for Reference)
Animal Research: ^[2]	- Collapse Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells Dosages: ~100 mg/kg/day Administration: Injection i.p. (Only for Reference)

References

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Solubility (25°C)

In vitro	DMSO	52 mg/mL (196.74 mM)
	Ethanol	3 mg/mL (11.35 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 2% DMSO+30% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing.	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Vorinostat (SAHA) SDF

Molecular Weight	264.3
Formula	C₁₄H₂₀N₂O₃
CAS No.	149647-78-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	MK0683
Smiles	C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2020-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03022565	Withdrawn	Drug: Vorinostat	Uveal Melanoma	University of Miami\|University of Miami Sylvester Comprehensive Cancer Center	January 2020	Early Phase 1
NCT03167437	Recruiting	Drug: Vorinostat\|Drug: Ustekinumab	Crohn''s Disease	National Institute of Allergy and Infectious Diseases (NIAID)\|National Institutes of Health Clinical Center (CC)	October 30 2017	Phase 1\|Phase 2
NCT03056495	Recruiting	Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat)	Alzheimer Disease	German Center for Neurodegenerative Diseases (DZNE)\|University Hospital Bonn\|University of Göttingen	September 28 2017	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
What’s the recommendation about reconstitution of the compound for in vivo animal study?
Answer:
We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

Selective HDAC Inhibitor

RGFP966 : HDAC3-selective, IC50=80 nM.
Selective HDAC Inhibitor

Rocilinostat (ACY-1215) : HDAC5-selective, IC50=5 nM.
Most Potent HDAC Inhibitor

Quisinostat (JNJ-26481585) : HDAC1, IC50=0.11 nM; HDAC2, IC50=0.33 nM.
FDA-approved HDAC Inhibitor

Vorinostat (SAHA, MK0683) : Approved by FDA against cutaneous T cell lymphoma.
Newest HDAC Inhibitor

RG2833 (RGFP109) ^New : Brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.

Related HDAC Products

LMK-235 ^New

LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively.
CAY10603 ^New

CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.
Domatinostat (4SC-202) ^New

Domatinostat (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
Panobinostat (LBH589)

Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3.
Entinostat (MS-275)

Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.
Trichostatin A (TSA)

Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM in cell-free assays.
Romidepsin (FK228, Depsipeptide)

Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM in cell-free assays, respectively. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells.

Features:More effective than other classical HDAC inhibitors such as TSA, TPX, and butyrate.
RGFP966

RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.
Tubastatin A

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis.
Mocetinostat (MGCD0103)

Mocetinostat (MGCD0103, MG0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to HDAC4, 5, 6, 7, and 8. Mocetinostat (MGCD0103) induces apoptosis and autophagy. Phase 2.

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By Signaling Pathways

By product type

Vorinostat (SAHA)