Vorinostat (SAHA)

For research use only.

Catalog No.S1047 Synonyms: MK0683

318 publications

Vorinostat (SAHA) Chemical Structure

CAS No. 149647-78-9

Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.

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Selleck's Vorinostat (SAHA) has been cited by 318 publications

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Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA, MK0683) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay. Vorinostat abrogates productive HPV-18 DNA amplification.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MkXDT4lv[XOnIFHzd4F6 MXOxJIg> NV:1W|ZKTE2VTx?= NYPDTWtw[W62aT3ISGFEOSCjY4Tpeol1gSC5aYToJGlEPTBib3[gNE4yOTJizszN M4j0XlEyQTZyNEi5
Friend leukemic cell NIT5UFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:yR2NbPTBizszN MV:3NkBp M{XaemROW09? M33GTmlEPTB;MD65PUDPxE1? MUixNlExQTlzMx?=
K562 NIPFeppMcW6jc3WgRZN{[Xl? NWXSbJg6PiCq MXzEUXNQ NI\X[FFKdmirYnn0bY9vKG:oIHj1cYFvKGirc4TvcoUh\GWjY3X0fYxie2ViKH3pfJR2emVib3[gTGRCSzFiYX7kJGhFSUN{KTD3bZRpKEmFNUCgc4YhOC5yMTFOwG0> NYTTZXZzOTJ2MUmzPFA>
HT1080 NVnZSmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHhO|IhcA>? NF:5WIRFVVOR NWOz[4l{UUN3ME2yMlQh|ryP MmLZNVIzPzBzN{W=
H1299 MVrLbY5ie2ViQYPzZZk> MV:yNEBucW5? MYrEUXNQ M4fO[2lvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJTEGFIHXufplu\SC5aYToJGlEPTBib3[gNE4yQTRizszN NIruUokyPDV{MUSyNi=>
H1299 NYm5VFdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LWPVczKGh? NFzWV2FFVVOR MVzJR|UxRTdwMkSg{txO MmLzNVQ2OjF2MkK=
HeLa MX3LbY5ie2ViQYPzZZk> M2W4cFMxKG2rbh?= NVHvNmV[UW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? NFTDRpQyPTZyM{m0PS=>
LOX-IMVI MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofEOFghcA>? M{\lUGlEPTB;MT6zJO69VQ>? NHnTTZoyPTdzNUS3NC=>
NCI-H226 NHS4OGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nWTVQ5KGh? NXS0TZNSUUN3ME2yMlYh|ryP NFTpVHkyPTdzNUS3NC=>
RXF-631L NV6xNJFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH0SXk1QCCq NEDFbm1KSzVyPUKg{txO MUOxOVcyPTR5MB?=
SNB-78 M{HoZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzJOFghcA>? NHH3fldKSzVyPUG2JO69VQ>? NY\mbZpEOTV5MUW0O|A>
St-4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETGR4k1QCCq NInLfoZKSzVyPUWuNkDPxE1? NHL3dVIyPTdzNUS3NC=>
ARP1 MnP5SpVv[3Srb36gRZN{[Xl? M1v2W|Ih|ryP MVi2JIg> NYG3UnpEUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NHTGcHkyPDd|NEiwOi=>
CEM NYPpZnFlU2mwYYPlJGF{e2G7 M{jqW|EhcA>? NEm0[|JFVVOR MWLJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{Og{txO M{LEd|E3PDJyME[0
HCT15 M1TBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHyUphLPDhiaB?= Mn\RS2k2OD1yLkiyJO69VQ>? MXixOlczOzJ{Nx?=
NCI-H23 Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXhOFghcA>? M3rMe2dKPTB;MD65NkDPxE1? MnexNVY4OjN{Mke=
GM15850 NXHHRndtU2mwYYPlJGF{e2G7 MnflNk42KM7:TR?= Mn\SPVYhcA>? MWfEUXNQ NXmwZnBwUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M3:yd|E3QTJzM{[3
GM15850 MXTLbY5ie2ViQYPzZZk> NX3TOmZJOi53IN88US=> NHPtc3o6PiCq NILvXplFVVOR MnPMTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MX[xOlkzOTN4Nx?=
GM15850 MX3LbY5ie2ViQYPzZZk> MlrmNk42KM7:TR?= NYfYNWZPQTZiaB?= M1zrVmROW09? MlLBTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEGyJIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NIHsWlYyPjl{MUO2Oy=>
GM15850 Mn21T4lv[XOnIFHzd4F6 MUGyMlUh|ryP MXK5OkBp MnPDSG1UVw>? MnqzTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEmgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NEfITXgyPjl{MUO2Oy=>
GM15850 MXTLbY5ie2ViQYPzZZk> NFjYcG0zNjVizszN NYjIWZhHQTZiaB?= NH7ZZXZFVVOR MX\Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? M131dFE3QTJzM{[3
GM15850 NF\XTGlMcW6jc3WgRZN{[Xl? NEjBWI4zNjVizszN NVK5UolSQTZiaB?= M1WxVmROW09? NUDacIV5UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NVrSUnVTOTZ7MkGzOlc>
U937 Mn\6SpVv[3Srb36gRZN{[Xl? NHHzcoU2KM7:TR?= NH;BRWYzPCCq MlztSG1UVw>? NEH3dnZE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn M2riPFE4ODB2N{G4
H661 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\BS281QCCq NVXtW2c{UUN3ME2xJO69VQ>? NVz5XGRCOTdzNUewNFk>
U937 M2W3W2Z2dmO2aX;uJGF{e2G7 NVP0Zmt2PSEQvF2= Mnv2NlQhcA>? MlGySG1UVw>? MVXJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w M1[ybFE4PDR5N{Ww
U937 NFH6[pZHfW6ldHnvckBCe3OjeR?= MUWxJO69VQ>? MkPvNlQhcA>? MX7EUXNQ NX;CTWd{TW[oZXP0JI9vKGGucHjhJJR2[nWuaX6gZYNmfHmuYYTpc44> M3rPSlE4PDR5N{Ww
RAW264.7 NUTiWlBkTnWwY4Tpc44hSXO|YYm= NF3rOlEyOCEQvF2= M1XsOlI1cA>? M{i5TpdifGW{ MnjnTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= Ml7RNVc1Pzd3MUi=
RAW264.7 NHHLO3dHfW6ldHnvckBCe3OjeR?= NXvMVnM6OTBizszN NGfHXpkzPGh? NF62cXJ4[XSnch?= M3\oOmlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> M4PaOlE4PDd5NUG4
SC9 M4LLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGyOFg1QCCq MnznTWM2OD1yLk[wOkDPxE1? NFS3OJAyPzVyN{KxPS=>
ST14A NYC1cVZ5TnWwY4Tpc44hSXO|YYm= Ml[3OUBvVQ>? NWrSSXlUPzJiaB?= M3K1bWlv[3KnYYPlJIlvKFKHU2SvUnJUTiCvUl7BJIV5eHKnc4Ppc44> MlTONVc2PjV7OUO=
ST14A MVnGeY5kfGmxbjDBd5NigQ>? MmXKOUBvVQ>? MmL6O|IhcA>? MnTETY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? NUfJbmhnOTd3NkW5PVM>
PANC1 NEnvT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH3TYYyKM7:TR?= MkWyTWM2OD1yLkS1JO69VQ>? NFvMRlIyPzV6OEe0OC=>
PANC1 M4\aZWZ2dmO2aX;uJGF{e2G7 M3\Sb|Eh|ryP Mkj3NlQhcA>? MXPJcoNz\WG|ZTDpckBxOjGZQV[xM2NKWDFiZ3Xu[UBmgHC{ZYPzbY9v M{ToW|E4PTh6N{S0
PANC1 M363fWZ2dmO2aX;uJGF{e2G7 M4TmdFEh|ryP MVqyOEBp NEX6O2ZKdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> MXixO|U5QDd2NB?=
PT45 NWi3NJk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPJTWM2OD12IN88US=> NV\QTWZbOTd3OEi3OFQ>
ACHN M{TjOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nCfFIyKGh? M1PsNmdKPTB;MD62OUDPxE1? MnX3NVc3PjJ4ME[=
PC3 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXKyNUBp MlTiS2k2OD1yLkexJO69VQ>? Ml\VNVc3PjJ4ME[=
A431 M1H4fmN6fG:2b4jpZ{BCe3OjeR?= MofoO|IhcA>? MUTJR|UxRTRwMjFOwG0> Mo[zNVc3QTF5NkO=
Cal27 Mlf5R5l1d3SxeHnjJGF{e2G7 M1\NXFczKGh? MkXZTWM2OD1|LkKg{txO NFu1NosyPzZ7MUe2Ny=>
CCRF-CEM M4XNc2N6fG:2b4jpZ{BCe3OjeR?= NV7FOmtWPzJiaB?= NU\HWYlsUUN3ME2wMlgh|ryP MnzlNVc3QTF5NkO=
EOL1 NGL2UVVEgXSxdH;4bYMhSXO|YYm= NGK0WGo4OiCq M{XNU2lEPTB;MTFOwG0> MXixO|Y6OTd4Mx?=
Hec-1-A MU\DfZRwfG:6aXOgRZN{[Xl? M3fP[FczKGh? MlO1TWM2OD1zIN88US=> MYmxO|Y6OTd4Mx?=
HeLa M32xSGtqdmG|ZTDBd5NigQ>? NYPydo1kOTBizszN NVT2dXhLOzBibXnu Mn3NSG1UVw>? MX7Jcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlAzKM7:TR?= M4PQbFE4PjlzN{[z
RKOp21 Ml71R5l1d3SxeHnjJGF{e2G7 MWO3NkBp NGPa[m9KSzVyPUGuO|Yh|ryP NH3mc4kyPzZ7MUe2Ny=>
Saos2 NFj3ZVNEgXSxdH;4bYMhSXO|YYm= MYW3NkBp M1f0NGlEPTB;Mj6zJO69VQ>? MVyxO|Y6OTd4Mx?=
SK-OV-3 MYrDfZRwfG:6aXOgRZN{[Xl? NVTnSZk6PzJiaB?= M33id2lEPTB;Mj6yJO69VQ>? MYixO|Y6OTd4Mx?=
U87MG M4HNOWN6fG:2b4jpZ{BCe3OjeR?= NWXOXHU5PzJiaB?= NX[zR2gyUUN3ME2xNUDPxE1? NWfmNJFuOTd4OUG3OlM>
NUGC3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPtbppoPSEQvF2= M1jYXFI1KGh? NYDKd|hMT0l3ME2yMlc6KM7:TR?= NIWxWlAyPzlyNEi0Ny=>
CCD1059SK M1vLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjITWM2OD12Mz61JO69VQ>? MYixPFI1PzV3NB?=
HepG2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOwTWM2OD1yLkCwNFYh|ryP NVjOcWF[OTh{NEe1OVQ>
HT1080 M3jHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfKTWM2OD1yLkCwNlQh|ryP NXy3SZc3OTh{NEe1OVQ>
SKBR3 MlfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfQTWM2OD1yLkig{txO NFzOSFYyQDJ2N{W1OC=>
SNB78 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPlU2h1TUN3ME2xOkDPxE1? NIPNN5EyQDJ2N{W1OC=>
SQ20B MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTJTWM2OD1|IN88US=> MlP3NVgzPDd3NUS=
St4 NUP3elNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXhNWVHTUN3ME21MlIh|ryP MVyxPFI1PzV3NB?=
MCF7 NV7KUnF6TnWwY4Tpc44hSXO|YYm= MmnFNVAh|ryP NXO3fmpMQCCq MnLkSG1UVw>? NFXJTXhKdmS3Y4Tpc44hd2ZidIXieYxqdiCqeYDldoFk\XS7bHH0bY9v MU[xPFI3QTJ{Nh?=
HEK293 MUnLbY5ie2ViQYPzZZk> NFTp[XgyKGh? MkLGSG1UVw>? M2jlcGlvcGmkaYTpc44hd2ZiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNFMh|ryP NXTab3c{OTh|MEi1OlM>
HEK293 M4rIdGtqdmG|ZTDBd5NigQ>? MoLTNUBp Mle4SG1UVw>? NHrjWY5KdmirYnn0bY9vKG:oIFjERWM{KHerdHigTWM2OCCxZjCwMlA2PyEQvF2= NIHicXoyQDNyOEW2Ny=>
G401 Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnETIZCPzJiaB?= NEnUSYJFVVOR M{DweGlEPTB;MTFOwG0> MknaNVg{PzB|N{O=
HeLa NFzzOpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[1[FU4OiCq NI\GPHdFVVOR NFvsOnhKSzVyPUCuOFYh|ryP NFrrWnAyQDN5MEO3Ny=>
Human renal epithelial cell MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG2W2g4OiCq NHThTVhFVVOR MoPVTWM2OD1zNDFOwG0> NVjJd3FJOTh|N{CzO|M>
U937 M4\WdGZ2dmO2aX;uJGF{e2G7 NFO4[FQ2KM7:TR?= M4jVdFI1KGh? M2nWVWlv\HWldHnvckBw\iCqaYP0c45mKEh2IHj5dIVz[WOndInsZZRqd25? MUCxPFM5OTJ|OB?=
U937 MmHZSpVv[3Srb36gRZN{[Xl? NUi0XYZlPSEQvF2= NWTLS5B2OjRiaB?= MXjJcoR2[3Srb36gc4Yh[WyyaHGgeJVjfWyrbjDofZBmemGlZYT5cIF1cW:w Ml;6NVg{QDF{M{i=
U937 MVjGeY5kfGmxbjDBd5NigQ>? NYnFOWd5PSEQvF2= MV:yOEBp M1nWPWlv\HWldHnvckBw\iCyMkGg[ZhxemW|c3nvci=> M4nX[VE5OzhzMkO4
U937 NWL4UWtYTnWwY4Tpc44hSXO|YYm= MUi1JO69VQ>? MXiyOEBp MYLJcoR2[3Srb36gc4Yh[XCxcITvd4l{ NFzFb4IyQDN6MUKzPC=>
U937 MmfUSpVv[3Srb36gRZN{[Xl? M3[yW|Uh|ryP MoP0NlQhcA>? M2K5Wmlv\HWldHnvckBw\iCpcnHueYxw[3m2aXOg[Iln\mW{ZX70bYF1cW:w Mle1NVg{QDF{M{i=
U937 MV;LbY5ie2ViQYPzZZk> NXSwWnU4PSEQvF2= NHPUOYozPCCq NVztZXhFUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDNS=> NVXZWoRlOTh|OEGyN|g>
U937 M4O1b2tqdmG|ZTDBd5NigQ>? Ml3zOUDPxE1? NVGxSJljOjRiaB?= NWm5eG4zUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDOC=> NIHYOpgyQDN6MUKzPC=>
HEK-TE NX7lNmZ4TnWwY4Tpc44hSXO|YYm= Mny4OUDPxE1? MVK2bC=> MmL1SG1UVw>? NWjXe4o4UW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDhZ4V1gWyjdHnvci=> MVixPFQ{PDF2NB?=
HPDE6c7 NUHIbVZmS3m2b4TvfIlkKEG|c3H5 M4jEUVUxKM7:TR?= M1LTWFczKGh? NY\mSWVNTE2VTx?= MXrJR|UxRTFwMzFOwG0> NYHzTo1vOTh2OUS0OlM>
Human microvascular epithelial cell M3PLbmN6fG:2b4jpZ{BCe3OjeR?= NX:1dG9MPTBizszN MljQO|IhcA>? M1;pTGROW09? NYHrXFBWUUN3ME2xMlMh|ryP MV2xPFQ6PDR4Mx?=
Hup T3 MYfDfZRwfG:6aXOgRZN{[Xl? NYe1eJk6PTBizszN NYqzUHR6PzKq NILzZodFVVOR NHjCU5VKSzVyPUCuPEDPxE1? NF7uT20yQDR7NES2Ny=>
Mia Paca2 NV\ROHdyS3m2b4TvfIlkKEG|c3H5 MonkOVAh|ryP NFXTbHg4Omh? MmHKSG1UVw>? MVjJR|UxRTFwMTFOwG0> NYrDRZhoOTh2OUS0OlM>
Panc 04.03 NHK1Zm9EgXSxdH;4bYMhSXO|YYm= MmnJOVAh|ryP MX23Nog> NVTYZpJOTE2VTx?= NYflTWdlUUN3ME2xMlIh|ryP MXmxPFQ6PDR4Mx?=
SU 86.86 NF\QPYZEgXSxdH;4bYMhSXO|YYm= M1HOS|UxKM7:TR?= MnLQO|Jp M2i4OmROW09? NELmXpdKSzVyPUGuN{DPxE1? Mnf1NVg1QTR2NkO=
HEK293 Ml3rT4lv[XOnIFHzd4F6 MXKzJIg> MnX6TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDISGFEPiCneIDy[ZN{cW:wIIfpeIghUUN3MDDv[kAxNjBzOTFOwG0> NGTXc5gyQDV3OE[2PS=>
HeLa MV3LbY5ie2ViQYPzZZk> MWiyJIg> NEW2cIRKdmirYnn0bY9vKG:oIH71Z4xm[XJiSFTBR{B4cXSqIFnDOVAhd2ZiMD6wPFMh|ryP NELwT2kyQDV3OE[2PS=>
RAW264.7 NV3OSJp5TnWwY4Tpc44hSXO|YYm= NGjOT3YzKM7:TR?= MorRN{42KGh? MX3EUXNQ M3\WS2FvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDpcoZm[3SnZDD3bZRpKEmFNUCgc4YhOC5zMTFOwG0> NFPCRWQyQDZ2NEm2PS=>
NB4 NGTsWJQ1QGh? MYTEUXNQ NVvlRWFXUUN3ME2wMlYh|ryP NHrod3IyQDd{M{O0PS=>
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HCT116 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTwUmg4Omh? NU\MZlBZTE2VTx?= NVW3OGJFUUN3ME2wMlMyKM7:TR?= NYjtRnpNOTlyOESyPVQ>
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NCI-H2122 NHLl[21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLHNYw4OiCq MX7JR|UxRTdwNTFOwG0> NXL2V5kzOjBzNEO3O|g>
NCI-H358 MlnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HMWFczKGh? M4TTOWlEPTB;Mj61JO69VQ>? NEPFUpEzODF2M{e3PC=>
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Caco-2 M1y4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzMNVAxKM7:TR?= M1jucVQ5cA>? MkXySG1UVw>? NFjTXlBKSzVyPUiuNUDPxE1? MWOyNFE1Ozh2MB?=
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Caco-2 NFWwfFJMcW6jc3WgRZN{[Xl? M4[xelAvOzF4IH7NJJRwKDNzLk[g{txO NHezflQ1KGh? NWnUcYtlTE2VTx?= NGXTUJVGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? M3;ub|IxOTR|OESw
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Caco-2 NYHHeY1lU2mwYYPlJGF{e2G7 M3[x[lYvOzJibl2geI8hPjN{IN88US=> NHrIRoE1KGh? M2LpXWROW09? Mk\zSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN3IIfpeIghUUN3MDDv[kAyOi54IN88US=> M4qye|IxOTR|OESw
Caco-2 M3vJV2tqdmG|ZTDBd5NigQ>? M3SxT|YvOzJibl2geI8hPjN{IN88US=> MWK0JIg> NETieVZFVVOR Mn7CSZghfmm4bzDpcohq[mm2aX;uJI9nKGi3bXHuJGhFSUN5IIfpeIghUUN3MDDv[kA1OSEQvF2= MmSxNlAyPDN6NEC=
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HepG2 M{POSGtqdmG|ZTDBd5NigQ>? M4T3NFUh|ryP MXO2bC=> Mn\KSG1UVw>? MVTJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDobZN1d26nIHHj[ZR6dGG2aX;u M3TvXVIxOTR|OESw
HepG2 M1nQXWtqdmG|ZTDBd5NigQ>? Mo\kOUDPxE1? Mon2Oog> MkTPSG1UVw>? Ml\ITY5lfWO2aX;uJI9nKEiGQVOtcYVlcWG2ZXSgbIl{fG:wZTDofZBmemGlZYT5cIF1cW:w NWPJR2N4OjBzNEO4OFA>
HepG2 NHrwcYRMcW6jc3WgRZN{[Xl? NWXNWGt[PSEQvF2= MljkOog> MmHTSG1UVw>? M3\hbGlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NFu3[VAzODF2M{i0NC=>
HepG2 M2\qXGtqdmG|ZTDBd5NigQ>? Mn3DOUDPxE1? NEHocZY3cA>? M3HTc2ROW09? MVPJcoR2[3Srb36gc4YhUESDQz3t[YRq[XSnZDDIN{9JPCCqaYP0c45mKGGlZYT5cIF1cW:w NFvhXJYzODF2M{i0NC=>
COLO205 NEDWRVVMcW6jc3WgRZN{[Xl? NGXIUHIyOCEQvF2= MVWyOEBp NVX0OVFVTE2VTx?= NVLzb5JvUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NEXRbHYzODR3MUO3PC=>
SCC4 NUDhNoJSU2mwYYPlJGF{e2G7 MX6xJO69VQ>? NY[0UVd7OjSq NXzxb4VSUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJJR2[nWuaX6gZYNmfHmuYYTpc44> MnzsNlA1PTJ{MkW=
SCC4 Mom2T4lv[XOnIFHzd4F6 NGfUfXUyKM7:TR?= M2L5eFI1cA>? MkHhTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViYXPleJlt[XSrb36= NVnqUYtWOjB2NUKyNlU>
SCC4 M4rrU2Z2dmO2aX;uJGF{e2G7 NVfMVGlpOSEQvF2= M{jRXVUhdWmw Mo\YRYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= MUGyNFQ2OjJ{NR?=
NB4 Mn;VSpVv[3Srb36gRZN{[Xl? NIfaNWI2KM7:TR?= MknONlQhcA>? NHraNHZFVVOR MWLD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn NWXLbJpOOjB2OUG0OFA>
NB4 MkjlT4lv[XOnIFHzd4F6 Ml7aOUDPxE1? MXmyOEBp MXjEUXNQ M{jiSmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDhZ4V1gWyjdHWgeJVjfWyrbjDs[ZZmdA>? MV2yNFQ6OTR2MB?=
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A431 M4XrcmN6fG:2b4jpZ{BCe3OjeR?= M4LTTlczKGh? M3HnUWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiC5aYToJGlEPTBib3[gOE4zKM7:TR?= MnLtNlExQDB4Mkm=
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CAL27 NEXLb5pEgXSxdH;4bYMhSXO|YYm= NFfpXYU4OiCq NV\iSGhQS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjD3bZRpKEmFNUCgc4YhOy5{IN88US=> MWqyNVA5ODZ{OR?=
HeLa MmezR5l1d3SxeHnjJGF{e2G7 M3zlRlczKGh? MoLTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKHerdHigTWM2OCCxZjCxMlUh|ryP NUfHTHl3OjFyOEC2Nlk>
Sf21 NXn4ZpF3U2mwYYPlJGF{e2G7 M2nYUVMhcA>? NF3J[YFKdmirYnn0bY9vKG:oIF\sZYchfGGpZ3XkJIh2dWGwIILlZ49u[mmwYX70JGhFSUN6IHX4dJJme3OnZDD3bZRpKEmFNUCgc4YhOS5{IN88US=> MojRNlExQDB4Mkm=
SKBR3 NITlUG1EgXSxdH;4bYMhSXO|YYm= MWO3NkBp MofXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= NYPFS4lIOjFyOEC2Nlk>
SKOV3 MknqR5l1d3SxeHnjJGF{e2G7 NWLqOXhHPzJiaB?= MW\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT29XOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlIh|ryP NU\SW4R[OjFyOEC2Nlk>
COR-L23 MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWmxNEDPxE1? NEnOfGw4OiCq NFr1coZFVVOR M4K2[mdKPTB;MT6xJO69VQ>? NUnyZ5JzOjFyOEC2OFc>
DU145 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPwNVAh|ryP NEC4TmI4OiCq NFHHV4ZFVVOR NF\5d3FIUTVyPUGuNFUh|ryP NVPRXWZ2OjFyOEC2OFc>
LoVo NGHEUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC3WpoyOCEQvF2= MnKwO|IhcA>? MkLHSG1UVw>? NV3NbnY1T0l3ME2xMlch|ryP MVmyNVA5ODZ2Nx?=
MCR5-SV2 NHHpe4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjaNVAh|ryP MYe3NkBp Mnj4SG1UVw>? NWjyOXRET0l3ME2yMlEh|ryP NFTVU2EzOTB6ME[0Oy=>
HCT116 MknMT4lv[XOnIFHzd4F6 M4fHPFMxKM7:TR?= NVzYXFhIOzBiaB?= MoXUSG1UVw>? NVHwTXBoUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4Yh[WyyaHGteJVjfWyrbjDhZ4V1gWyjdHnvci=> MYKyNVA5ODZ2Nx?=
HCT116 MUjLbY5ie2ViQYPzZZk> NEDwT4w{OCEQvF2= MkKzN|AhcA>? Mn\GSG1UVw>? NEfsPI9KdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= NXfnNIwxOjFyOEC2OFc>
U937 NW\LTG1EU2mwYYPlJGF{e2G7 M1nX[|Uh|ryP MnnBNlQhcA>? MlP1SG1UVw>? MnrCTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? M13xe|IyOjl{NEmy
U937 NXzncnVvU2mwYYPlJGF{e2G7 MXO1JO69VQ>? M1vFU|I1KGh? NYTzWmRsTE2VTx?= MmfYTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzF6 NYjNU4ZbOjF{OUK0PVI>
U937 NI\JNnlMcW6jc3WgRZN{[Xl? NH\VXoQ2KM7:TR?= NUG3do16OjRiaB?= MoP4SG1UVw>? M3PXdWlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBx[W5vYXPleJlt[XSnZDDobZN1d26nIFi0JIxmfmWu M3fFTlIyOjl{NEmy
U937 Mo[3T4lv[XOnIFHzd4F6 NVXKVI93PSEQvF2= MWixOUBucW5? MmrHSG1UVw>? MVPJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gbIl{fG:wZTDIN{Bi[2W2eXzheIlwdiCuZY\lcC=> Ml22NlEzQTJ2OUK=
A2780 NYC4XFZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHINHhSQTZiaB?= MVPEUXNQ MWPJR|UxRTFwNkKg{txO M1ixNlIyPjN2NEOw
COLO205 M{LW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUi5OkBp MlXwSG1UVw>? M4LhWWlEPTB;Mj6xNkDPxE1? MoLuNlE3OzR2M{C=
Hep3B MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnLWog5PDhiaB?= NHjlWYdFVVOR M1LBc2dKPTB;MT6yNUDPxE1? MV2yNVcyOjF2Nh?=
GM11272 NFO4ToJHfW6ldHnvckBCe3OjeR?= M3uzeVExOCCwTR?= MUW3NkBp NGToPVVFVVOR NV;ZT3ozWmWjY4TpeoF1cW:wIH;mJG1mS3B{IH31eIFvfCCneIDy[ZN{cW:wIHH0JFExKHSxIEGwNEBvVQ>? NWLz[IM5OjF6NEC3NVY>
CFBE41o M{nyUGtqdmG|ZTDBd5NigQ>? NF[3WpE2KM7:TR?= MoHmSG1UVw>? M2\6RWRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? MVSyNVk5PDl3OB?=
CFBE41o Mnv1SpVv[3Srb36gRZN{[Xl? MnK4NUDPxE1? NVHDcFN{OjRiaB?= NYTnVWw6TE2VTx?= NGLXXYFT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= MXyyNVk5PDl3OB?=
DU145 MXnLbY5ie2ViQYPzZZk> MlzINk42KM7:TR?= MonMNlQhcA>? M1PpZ2ROW09? NVPYe3dpUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? NV3X[4NROjJ{NkCxOlY>
DU145 NHHPSI1McW6jc3WgRZN{[Xl? NUj0O4Y{PSEQvF2= Mlu1NlQhcA>? M3jCTGROW09? MYHJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= MkWyNlIzPjBzNk[=
DU145 MX7LbY5ie2ViQYPzZZk> M1TIOlUh|ryP Mnu1NlQhcA>? NGS4fXRFVVOR MkG4TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? MlH4NlIzPjBzNk[=
786-0 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTHOk4zKM7:TR?= NUfVVmQ4PzJiaB?= NE\PfYZFVVOR M4DBT2dKPTB;Mz6yJO69VQ>? NHXVUYszOjR|NU[2PS=>
A498 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTRTIlGPi5{IN88US=> NEmxWIE4OiCq NHj3U2RFVVOR M2fmTWdKPTB;MT62JO69VQ>? NGf6bmQzOjR|NU[2PS=>
A549/ATCC M4DE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfBOk4zKM7:TR?= MoCzO|IhcA>? MlL4SG1UVw>? NVnhfmpYT0l3ME2xMlYh|ryP MWiyNlQ{PTZ4OR?=
ACHN M{XHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXXOk4zKM7:TR?= MYm3NkBp M3ezXWROW09? NWK0dohST0l3ME2xMlMh|ryP M2rBbFIzPDN3Nk[5
BT549 NYThc3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX62MlIh|ryP Mkn6O|IhcA>? Mmn6SG1UVw>? MYHHTVUxRTFwMzFOwG0> M33He|IzPDN3Nk[5
EKVX MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXOS3o3NjJizszN MnTGO|IhcA>? NI\RR2pFVVOR M4HUO2dKPTB;MT6zJO69VQ>? NEfG[JIzOjR|NU[2PS=>
HCT15 MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfLOk4zKM7:TR?= NFTy[ZY4OiCq NUjOVopWTE2VTx?= NYXPbHVDT0l3ME2yMlUh|ryP MYOyNlQ{PTZ4OR?=
HOP92 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXy2MlIh|ryP NYnBXmJHPzJiaB?= NXzpTVhTTE2VTx?= Mlv4S2k2OD12IN88US=> NWr2VYtHOjJ2M{W2Olk>
IGROV1 MmHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYW2MlIh|ryP M2P4RlczKGh? NXjmfWd[TE2VTx?= NVmwUmNUT0l3ME2xMlMh|ryP NIDoVWIzOjR|NU[2PS=>
LOXIMVI MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rIT|YvOiEQvF2= NY[wXI5qPzJiaB?= NGKzboJFVVOR NF;RZ41IUTVyPUGg{txO NFy2VFczOjR|NU[2PS=>
M14 NHrLZXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmraOk4zKM7:TR?= NYfhSolTPzJiaB?= M{TSSWROW09? NVvUeJRJT0l3ME2xMlMh|ryP Mn\WNlI1OzV4Nkm=
MALME-3M NHrrdnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HXS|YvOiEQvF2= MX[3NkBp MYfEUXNQ MlToS2k2OD1yLkOyJO69VQ>? M4\GZ|IzPDN3Nk[5
MCF10A NU\yPYw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\XOk4zKM7:TR?= M{nMWFQ5KGh? M4K0RmROW09? MoTOS2k2OD17Lk[g{txO NES3fpIzOjR|NU[2PS=>
MDA-MB-435 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVm2MlIh|ryP M3PFUVczKGh? Mlj5SG1UVw>? MVnHTVUxRTBwNTFOwG0> MknRNlI1OzV4Nkm=
MDA-MB-468 MkPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PEcFYvOiEQvF2= NV:5VGFNPzJiaB?= NV;sOnhtTE2VTx?= Mnj4S2k2OD1yLk[zJO69VQ>? NY\pOnVKOjJ2M{W2Olk>
MOLT4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLmOk4zKM7:TR?= NUDxcGk1PzJiaB?= NETpPWxFVVOR M4[0OWdKPTB;MD60JO69VQ>? NWHpUmdpOjJ2M{W2Olk>
NCI-ADR-RES MnPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqzOk4zKM7:TR?= NGm3VmI4OiCq NUDLSW92TE2VTx?= NX\BPYtiT0l3ME2wMlE3KM7:TR?= MniwNlI1OzV4Nkm=
NCI-H23 NXPyXmR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXoO4o3NjJizszN NVvncmZ1PzJiaB?= NUj5T|dGTE2VTx?= NYX6V255T0l3ME2xJO69VQ>? MX:yNlQ{PTZ4OR?=
NCI-H322M NFLSdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojFOk4zKM7:TR?= NXrI[lk6PzJiaB?= NIrZSWlFVVOR MlPJS2k2OD1yLke5JO69VQ>? M37tdlIzPDN3Nk[5
NCI-H460 NX;vXoR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPnPZN4Pi5{IN88US=> M{jKT|czKGh? M1e3TGROW09? M1ztfmdKPTB;MD63PUDPxE1? M1;I[VIzPDN3Nk[5
NCI-H522 NV7SNGYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYW2MlIh|ryP M3nv[VczKGh? MkH1SG1UVw>? MYjHTVUxRTBwNTFOwG0> M4HSS|IzPDN3Nk[5
OVCAR3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYCzNXpqPi5{IN88US=> NGDnPWk4OiCq M1;2fWROW09? MVnHTVUxRTFwMzFOwG0> MnvqNlI1OzV4Nkm=
OVCAR4 NXfoN5A5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY[2MlIh|ryP M2rPcFczKGh? M4XjTWROW09? NI[5XotIUTVyPUSg{txO M1\Lc|IzPDN3Nk[5
OVCAR5 MkHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe2MlIh|ryP Mnj4O|IhcA>? MX;EUXNQ M1XveWdKPTB;MD63PUDPxE1? MVmyNlQ{PTZ4OR?=
OVCAR8 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3OUldXPi5{IN88US=> NH34fYw4OiCq MkPuSG1UVw>? M{TCcmdKPTB;MD61JO69VQ>? M1HBNlIzPDN3Nk[5
RXF393 M2HZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHjOk4zKM7:TR?= MlTOO|IhcA>? NHjiN4xFVVOR MVXHTVUxRTFwMzFOwG0> MWKyNlQ{PTZ4OR?=
SF268 M3TtNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfD[Zc6Pi5{IN88US=> MUO3NkBp NWXyRpdzTE2VTx?= M4LmfWdKPTB;MT62JO69VQ>? NX;qfHBvOjJ2M{W2Olk>
SF295 M1rufWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnKOoM3NjJizszN MVO3NkBp NVrsVpZJTE2VTx?= MlmxS2k2OD1zLk[g{txO NG\EPWEzOjR|NU[2PS=>
SF539 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D0NVYvOiEQvF2= MoriO|IhcA>? MmK1SG1UVw>? MnTCS2k2OD1{IN88US=> MV6yNlQ{PTZ4OR?=
SK-MEL-2 M2jhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHuzcZM3NjJizszN NUP4S20{PzJiaB?= MknLSG1UVw>? M2DLfWdKPTB;MT6zJO69VQ>? NUPHc3BWOjJ2M{W2Olk>
SK-MEL-28 NFHUTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHjW3h4Pi5{IN88US=> MVy3NkBp Ml7xSG1UVw>? NIm4blhIUTVyPUGg{txO NWf2SIpmOjJ2M{W2Olk>
SK-MEL-5 Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi4Ok4zKM7:TR?= M3L4NlczKGh? NF;3O25FVVOR NV;IcGVpT0l3ME2wMlY{KM7:TR?= NV[4UVRxOjJ2M{W2Olk>
SKOV3 M{P1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnzOlY3NjJizszN NY\OeXA2PzJiaB?= MX\EUXNQ MYrHTVUxRTFizszN MkHmNlI1OzV4Nkm=
SN12C M4\Cb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVi2MlIh|ryP MnTUO|IhcA>? MnjkSG1UVw>? NXPsWFNXT0l3ME2yJO69VQ>? NYL0coczOjJ2M{W2Olk>
SNB19 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjue4h3Pi5{IN88US=> NV;tU|g{PzJiaB?= MoLSSG1UVw>? NWPKNVV7T0l3ME2wMlY{KM7:TR?= M1LV[FIzPDN3Nk[5
SNB75 MnyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLzeGtrPi5{IN88US=> NVztW4M2PzJiaB?= MoDGSG1UVw>? NFO0cFJIUTVyPUCuO|kh|ryP NHvQe4IzOjR|NU[2PS=>
SR MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zQNVYvOiEQvF2= NUXBWIg{PzJiaB?= Mnj5SG1UVw>? MXjHTVUxRTBwNDFOwG0> NYXrSIVQOjJ2M{W2Olk>
T47D NWCwZ2ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnvfFlNPi5{IN88US=> M4jzZVczKGh? MmPCSG1UVw>? MYrHTVUxRTBwNTFOwG0> Ml\ENlI1OzV4Nkm=
TK10 NYPNWWpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jJWlYvOiEQvF2= MkS3O|IhcA>? NFjYWIlFVVOR MmXBS2k2OD1yLk[zJO69VQ>? NWq2fnZYOjJ2M{W2Olk>
UACC257 NFr4[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7pOk4zKM7:TR?= MoDDO|IhcA>? M4C2V2ROW09? MknES2k2OD1yLkWg{txO MnTKNlI1OzV4Nkm=
UACC62 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\tOk4zKM7:TR?= Mmr0O|IhcA>? NVfDe5g5TE2VTx?= MU\HTVUxRTBwNDFOwG0> M2HaNFIzPDN3Nk[5
UO31 NGHJVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\UPFYvOiEQvF2= NH:2UWs4OiCq MlzpSG1UVw>? MkLNS2k2OD1yLkWg{txO MV6yNlQ{PTZ4OR?=
Hep3B M4PpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvnWos1QCCq NIjuXotFVVOR M4HEW2dKPTB;MD62PUDPxE1? MmnwNlI1Ozl6NkO=
BE(2)-C MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r0O|czKGh? MnOzSG1UVw>? MXTJR|cxRTJizszN MUWyNlk{OjNzNh?=
Bel7402 M3q2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3raTVczKGh? NYrGTowxTE2VTx?= M4Lx[GdKQTB;MUeg{txO NWrMfVlZOjNyNkGzO|Y>
Bel7404 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LWfVczKGh? MWfEUXNQ M{nOWGdKQTB;MUig{txO NYrUeoQ4OjNyNkGzO|Y>
BGC823 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;0O|czKGh? NFzMV5VFVVOR MX\HTVkxRTdwNTFOwG0> MXWyN|A3OTN5Nh?=
MGC803 Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfyO|IhcA>? NFzod3ZFVVOR NIjZR3FIUTlyPUGwMlgh|ryP NH;RfXIzOzB4MUO3Oi=>
SGC7901 NI[xfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHvZno4OiCq MYLEUXNQ NUPKd5NOT0l7ME25MlQh|ryP MkL5NlMxPjF|N{[=
SKHEP1 MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX4W2c4OiCq NF\vWXNFVVOR MVvHTVkxRTF5IN88US=> NVLmSHFWOjNyNkGzO|Y>
SMMC7721 M3P6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrGbmY1PzJiaB?= NGLXbmlFVVOR NWLUW|lbT0l7ME2yNEDPxE1? Mof1NlMxPjF|N{[=
NUGC3 Mn\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXoe2UyOCEQvF2= M4HDbmdKRTJwOUSg{txO MoWyNlMyPjN|M{K=
A2780 CisR NXO4XGpoU2mwYYPlJGF{e2G7 MX6xPEBp NF;2OG1KdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP MnfUNlMzPTJ4MEO=
CAL27 sens NYPoTItnU2mwYYPlJGF{e2G7 MkPwNVghcA>? MWDJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO NHTaSZQzOzJ3Mk[wNy=>
CAL27 CisR M3PMdWtqdmG|ZTDBd5NigQ>? NH31XJAyQCCq M1vWVWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? NHnUfIEzOzJ3Mk[wNy=>
KYSE-510 CisR NHHBPIZMcW6jc3WgRZN{[Xl? NHP6SHcyQCCq MWjJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNUmg{txO MnrMNlMzPTJ4MEO=
KYSE-510 sens MUfLbY5ie2ViQYPzZZk> M4T3b|E5KGh? NGTiem5KdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuO{DPxE1? MnPmNlMzPTJ4MEO=
MDA-MB-231 sens MWTLbY5ie2ViQYPzZZk> MWOxPEBp MULJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNkGg{txO NUTVNGZNOjN{NUK2NFM>
MDA-MB-231 CisR MULLbY5ie2ViQYPzZZk> MmO1NVghcA>? MlzpTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M2[1dlI{OjV{NkCz
ES2 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHJOFghcA>? M4nh[WROW09? NGPUTXZKSzVyPUGyMlch|ryP MUiyN|Q6OzR2OR?=
MDA-MB-231 M4fiRmtqdmG|ZTDBd5NigQ>? Ml:1NVAh|ryP NGi0cmI{OCCvaX6= NFnnU|ZFVVOR MVjJcohq[mm2aX;uJI9nKEiGQVOyZS=> MX:yN|Q6OzR2OR?=
MDA-MB-231 MYrLbY5ie2ViQYPzZZk> NFXI[FYyKM7:TR?= MVyyOEBp NWPCPJk2TE2VTx?= MXvJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGGlZYT5cIF1cW:wIHzleoVteyCxZjD0eYJ2dGmw M2PQVFI{PDl|NES5
HS68 MXzDfZRwfG:6aXOgRZN{[Xl? Mn73NVAh|ryP MnPKO|IhcA>? NWXQbpZOTE2VTx?= NHz1No5KSzVyPUSuOkDPxE1? NVTjfFE3OjN3N{C1OFI>
MEF NF\IcW1EgXSxdH;4bYMhSXO|YYm= Ml7ENVAh|ryP Ml7WO|IhcA>? NUW3XpAyTE2VTx?= NGnOWItKSzVyPUSuOEDPxE1? M4HRPFI{PTdyNUSy
BGC823 NWXZVZlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvOWVdFVVOR NVTUcmJRT0l3ME2zMlA6KM7:TR?= MknyNlM3ODF5ME[=
High5 NVH0WnA{U2mwYYPlJGF{e2G7 M4XReFI1KGh? NFfpXZpKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM3KHerdHigTWM2OCCxZjCwMlA6KM7:TR?= MluyNlM3ODJ3MkO=
High5 MoHQT4lv[XOnIFHzd4F6 M2fhbVI1KGh? NH\rSoVKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= MWSyN|YxOjV{Mx?=
High5 NULpcoJIU2mwYYPlJGF{e2G7 M3[xWlI1KGh? NWL5[mYxUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEOyC5aYToJGlEPTBib3[gNE4yPyEQvF2= Mlm0NlM3ODJ3MkO=
A549 NUWwXYJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVna[XhmTE2VTx?= NULkd|BiUUN3ME2xMlA4QSEQvF2= MlTuNlM3PDR{MUC=
HCT116 Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknnSG1UVw>? NW\mcWtIUUN3ME2wMlc2PyEQvF2= MoLlNlM3PDR{MUC=
K562 NUmzTYw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPEUXNQ NGruTVhKSzVyPUCuOlQ2KM7:TR?= NF;n[oszOzZ2NEKxNC=>
GBC-SD NFXIZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fnS|Uh|ryP NXyxe|hGPzJiaB?= M4nEcGROW09? NHnJdYhKSzVyPUG0Mlgh|ryP MV[yN|cxPzJ4MB?=
HGC27 NH\IPW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Px[|Uh|ryP MXy3NkBp NVGxWVJoTE2VTx?= MVjJR|UxRTVwNDFOwG0> NX:5VFRGOjN5MEeyOlA>
HL60 NHnuSmtMcW6jc3WgRZN{[Xl? MonHOUDPxE1? MYCyOEBp MWDEUXNQ MYDJcohq[mm2aX;uJI9nKEiGQVO= NUHC[GJ[OjN5MEeyOlA>
Vero NHHS[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3sb4k4OiCq MlLISG1UVw>? MnjWTWM2OD1yLkmg{txO M3jYfVI{Pzh4NEWy
NCI60 MWfDfZRwfG:6aXOgRZN{[Xl? NHeyb4o1QCCq NGDs[GhFVVOR M3v5XGdKRTBwNUOg{txO NFnsdmYzPDBzNUOyOy=>
SW620 M2S5VmN6fG:2b4jpZ{BCe3OjeR?= Mk\QOFghcA>? NGDvco5FVVOR MXvHTV0xNjV2IN88US=> NX[4e3l3OjRyMUWzNlc>
U251 MWrDfZRwfG:6aXOgRZN{[Xl? M4fKe|Q5KGh? NFvwe4RFVVOR NI\ZTFNIUT1zLkWzJO69VQ>? M1nOelI1ODF3M{K3
KM12 M{XsZmN6fG:2b4jpZ{BCe3OjeR?= NWLNcJdzPDhiaB?= M1rsbWROW09? NIfWdpNIUT1zLki4JO69VQ>? MWCyOFAyPTN{Nx?=
Hs578T MWfDfZRwfG:6aXOgRZN{[Xl? MVK0PEBp M1vXRmROW09? M2ewd2dKRTRwOEOg{txO NYLkemZ7OjRyMUWzNlc>
MDA-MB-231 NXTKU5UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHG[WVxPDhiaB?= NWf5eFh6UUN3ME2wMlE3KM7:TR?= NVnUeWVCOjRyOUWwNVY>
MCF7 NXn1UYVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rNN|Q5KGh? MnPjS2k:OC52NTFOwG0> NWLnO5VnOjRzMUm1OVU>
MDA-MB-435 NHnEZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPTd4dOPDhiaB?= M1;TbGdKRTBwOEig{txO NF7WcVQzPDFzOUW1OS=>
AsPC1 M4nH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX6zNEDPxE1? MkHaOFghcA>? NITle2RFVVOR MUTJR|UxRTNwNk[g{txO NH;3W3IzPDF6NUO3PC=>
Jurkat E6.1 MYTLbY5ie2ViQYPzZZk> M1rpZVIhcA>? NX62fHVRTE2VTx?= NHL5W5NKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= MmntNlQzPjF6NkK=
KG1 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYq0PEBp M1WxcmlEPTB;MT6xOUDPxE1? MV2yOFUzPTByMx?=
HEL MlfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nPNlQ5KGh? M3HFVmROW09? M1;5[GlEPTB;MD60PUDPxE1? MUeyOFY6PDB3NR?=
HSC3 NHHTRopEgXSxdH;4bYMhSXO|YYm= M37seFEzKGh? MWjEUXNQ MVvJR|UxRTBwN{Gg{txO MoP5NlQ4PjZ3NkC=
HT-29 NHrtWnpEgXSxdH;4bYMhSXO|YYm= MmH0NVIhcA>? NXzLXINnTE2VTx?= M17OVWlEPTB;MD63NkDPxE1? M1jiTVI1PzZ4NU[w
KB NH\lb49EgXSxdH;4bYMhSXO|YYm= NEDEUoMyOiCq M4DjRWROW09? NVfEdWtzUUN3ME2wMlc2KM7:TR?= NH[xUGozPDd4NkW2NC=>
H460 M37aWWN6fG:2b4jpZ{BCe3OjeR?= MnzGNVIhcA>? MojTSG1UVw>? NX35clVmUUN3ME2wMlgzKM7:TR?= M{TL[|I1PzZ4NU[w
MONE1 MkHQR5l1d3SxeHnjJGF{e2G7 NUH3TXllOTJiaB?= NXXscZpFTE2VTx?= MV7JR|UxRTFwMUig{txO NYjFeIo5OjR5Nk[1OlA>
MKN45 NVnMVYVlS3m2b4TvfIlkKEG|c3H5 MkPUNVIhcA>? MoHuSG1UVw>? MXnJR|UxRTFwMkWg{txO NVrzR5Z[OjR5Nk[1OlA>
TSGH MmHQR5l1d3SxeHnjJGF{e2G7 NXK5Vlg3OTJiaB?= NYjxWoU1TE2VTx?= NU[zXHVTUUN3ME2yMlA6KM7:TR?= MWOyOFc3PjV4MB?=
HL60 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVW3NkBp NF\wXYxFVVOR M3LlNmdKPTB;MD65N{DPxE1? MV[yOFkxODVyMB?=
HEK293 M2rTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIOzb|A4OiCq NFfOcJlFVVOR M2r2O2dKPTB;MUOg{txO MUOyOFkxODVyMB?=
Jurkat NEn4cVFEgXSxdH;4bYMhSXO|YYm= M1ntflExOCEQvF2= MXW3NkBp M1H6XWdKPTB;MD65JO69VQ>? MYSyOFkxODd2Mx?=
GM15850 NYHaSYpXU2mwYYPlJGF{e2G7 NFzRNYYzNjVizszN NWDlXHJ2QTZiaB?= Mo\PSG1UVw>? Ml7Q[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MXmxOlkzOTN4Nx?=
GM15850 NInDfnlMcW6jc3WgRZN{[Xl? M{XQfVIvPSEQvF2= MojpPVYhcA>? MnLSSG1UVw>? NGnRVG9ld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhPSCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NYL3VYxnOTZ7MkGzOlc>
GM15850 M1XabmtqdmG|ZTDBd5NigQ>? NFvyO3IzNjVizszN MlPKPVYhcA>? NHzSUWpFVVOR Monn[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MUmxOlkzOTN4Nx?=
GM15850 MmjpT4lv[XOnIFHzd4F6 NXfOVGtDOi53IN88US=> MmHHPVYhcA>? NETabYhFVVOR Mo\J[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MWqxOlkzOTN4Nx?=
GM15850 MXfLbY5ie2ViQYPzZZk> MoW4Nk42KM7:TR?= MmrBPVYhcA>? Mk\BSG1UVw>? NHfhXlZld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> M3rzUFE3QTJzM{[3
GM15850 M2\kTmtqdmG|ZTDBd5NigQ>? NGnRV3EzNjVizszN NFnheZI6PiCq NYPRXW1DTE2VTx?= M{XC[4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyPiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> M3TURlE3QTJzM{[3
GM15850 NWnRSnJETnWwY4Tpc44hSXO|YYm= MVm1JO69VQ>? MojiNVIhcA>? M1PaeWROW09? M2P4OYhieyCwbzDl[oZm[3Rib36gSnhPKG2UTlGg[ZhxemW|c3nvci=> MVWxOlkzOTN4Nx?=
U937 NEPISmNMcW6jc3WgRZN{[Xl? Mn\QOUDPxE1? NGr1NYszPCCq NY[xV2lNTE2VTx?= MV7oZZMhdm9iZX\m[YN1KG:wIHHsdIhiKHS3YoXsbY4h[WOndInsZZRqd25? M2KxTVE4PDR5N{Ww
U937 M4Pme2tqdmG|ZTDBd5NigQ>? NXXUd5NIOSEQvF2= NHm5TJozPCCq NWrOPIRiTE2VTx?= NEPWeWtp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MoXkNVc1PDd5NUC=
PANC1 MmjJSpVv[3Srb36gRZN{[Xl? NGnJSoEyKM7:TR?= MYKyOEBp MYHkc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= NVvpUXhWOTd3OEi3OFQ>
PANC1 MmrRSpVv[3Srb36gRZN{[Xl? MmPhNUDPxE1? M4jVNlQ5KCCq MYTkc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= M3T3dFE4PTh6N{S0
Caco-2 M2i3O2Z2dmO2aX;uJGF{e2G7 MVy1JO69VQ>? M{TXPVI1KGh? NHXndJdFVVOR NFn6dW5ld2W|IH7veEBqdmS3Y3WgVFIyX0GIMTDn[Y5mKGW6cILld5Nqd25? NEXkVIszODF2M{i0NC=>
SCC4 MUjGeY5kfGmxbjDBd5NigQ>? MnHVNUDPxE1? NFPwPJEyOCCvaX6= MVXEUXNQ NUPlSIFLcGG|IH7vJIFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36= NV\zU5V2OjB2NUKyNlU>
A549 MlzqSpVv[3Srb36gRZN{[Xl? MkPEOUDPxE1? MmGxN{Bp NWLOSYVPTE2VTx?= NY\teGNx\G:nczDuc5QhcW6mdXPlJIF2fG:yaHHnfUBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|NKUQ>? MWeyNFg2PTJyOB?=
HCT116 NILoWIhMcW6jc3WgRZN{[Xl? NYn2e5E5OC5|IN88US=> NXKzbZZFOzBiaB?= MmP6SG1UVw>? Ml23[I9meyCwb4SgbY5pcWKrdDDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u M1n0XlIyODhyNkS3
HepG2 MV3GeY5kfGmxbjDBd5NigQ>? M4PlPVExKM7:TR?= M1qwclI1KGh? M2nlO2ROW09? NIPRPJlld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGi7cHXyZYNmfHmuYYTpc44hd2ZicEWz Mnv3NlE2PDh3OEK=
GM11272 MnzWSpVv[3Srb36gRZN{[Xl? MV:wMlEh|ryP NYTFbYx[PzJiaB?= NUfFT2U6TE2VTx?= MYfkc4V{KG6xdDDy[YFkfGm4YYTlJG1mS3B{IH31eIFvfCCneIDy[ZN{cW:w NF[5N4szOTh2MEexOi=>
MDA-MB-231 NWLZVph1U2mwYYPlJGF{e2G7 MoDxNVAh|ryP MUK1JI1qdg>? M4Xkc2ROW09? NGf3UINld2W|IH7veEBqdmirYnn0JGhFSUN{YR?= Mn33NlM1QTN2NEm=
MDA-MB-231 M1fCUmtqdmG|ZTDBd5NigQ>? NFfmToMyKM7:TR?= NXS1VHhYOjRiaB?= Ml;qSG1UVw>? M{K2bYRw\XNibn;0JIlvcGmkaYSgTGRCSzZiYYPz[ZN{\WRiYYOgZYNmfHmuYYTpc44hdGW4ZXzzJI9nKHS3YoXsbY4> MWOyN|Q6OzR2OR?=
K562 M3LHOmtqdmG|ZTDBd5NigQ>? MYDkc4V{KG6xdDDpcohq[mm2IFjERWM> Ml7aNlM2QTFzMUG=
Jurkat Mn\6R5l1d3SxeHnjJGF{e2G7 NUfr[I5OOjBizszN NWiwe5plPzJiaB?= MkThSG1UVw>? M2TOe45wKGO7dH;0c5hq[2m2eTDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvci=> Mm[4NlQ{ODR|NEi=
HCT116 NGi3d4VCeG:ydH;zbZMhSXO|YYm= NHe1cIc{KM7:TR?= NVW3eFdvOjRiaB?= NUPWWnIzTE2VTx?= MmjZ[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCyNUOgdJJwfGWrbjDs[ZZmdA>? NUHGS|dbOjR5Nk[1OlA>
KASUMI-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfseYlKSzVyPUm5MlE4KG6P NF;qfIVUSU6JRWK=
KARPAS-45 NXm4PIMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTF5Mz64PUBvVQ>? MYjTRW5ITVJ?
BHT-101 M37jV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jue2lEPTB;MkS0MlE5KG6P MkLvV2FPT0WU
H9 MlmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX2UpVKSzVyPUK1OU4xPCCwTR?= MYjTRW5ITVJ?
PA-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ6Nj6yOkBvVQ>? M1PBNXNCVkeHUh?=
NEC8 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLmTWM2OD1{OEmuN|ghdk1? MX;TRW5ITVJ?
MHH-PREB-1 NYLaNnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILsbZVKSzVyPUK5OE42OyCwTR?= M37oZ3NCVkeHUh?=
NB7 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljKTWM2OD1|NEWuO|Qhdk1? NVPUUWtIW0GQR1XS
A3-KAW NYPifW1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDRTWM2OD12MECuOVkhdk1? MWDTRW5ITVJ?
NB69 NEjoTGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTRzMT63NUBvVQ>? MlfRV2FPT0WU
EoL-1-cell M2eyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\NTWM2OD12NUSyOUBvVQ>? MUDTRW5ITVJ?
CHP-212 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELKTnRKSzVyPUS1O{42OyCwTR?= NIrmb25USU6JRWK=
C2BBe1 NF\oe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXVTWM2OD12N{KuNVkhdk1? NXrWeo1NW0GQR1XS
697 M3G4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37uZWlEPTB;NEezMlQyKG6P M4PGTXNCVkeHUh?=
BCPAP NEPFNnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG2d21KSzVyPUWwNU41OiCwTR?= MkLCV2FPT0WU
L-363 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jRTWlEPTB;NUCzMlEhdk1? MmjEV2FPT0WU
ES8 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[xbnM{UUN3ME21NlMvPTNibl2= M{DrSnNCVkeHUh?=
BE-13 NFzRcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXzVFZIUUN3ME21NlYvQTZibl2= M1HSTnNCVkeHUh?=
CTB-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTV|Nz65NkBvVQ>? MX;TRW5ITVJ?
HD-MY-Z NGPEWIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTV|OD6xN{BvVQ>? M4jaOXNCVkeHUh?=
NKM-1 Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTV2ND6yO{BvVQ>? M4Ta[3NCVkeHUh?=
NCI-H720 NUX1UphMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P2SGlEPTB;NU[wMlE5KG6P M1r3eXNCVkeHUh?=
KY821 NVTwUZBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTV4Mz6yOUBvVQ>? MnG5V2FPT0WU
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JVM-3 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHQTWM2OD1zLki1OFUyKM7:TR?= M{S3TnNCVkeHUh?=
OS-RC-2 NFvQboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPwTWM2OD1zLki3NVUyKM7:TR?= MVHTRW5ITVJ?
COLO-320-HSR NWLHZ|hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwOEixPVch|ryP NHfVUWxUSU6JRWK=
HN M1u4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDmU2tKSzVyPUGuPFg4OjVizszN Moe3V2FPT0WU
HT M2TlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX3O4FKSzVyPUGuPFg6PDdizszN NGfiSVdUSU6JRWK=
LoVo MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4[5NGlEPTB;MT64PVgyKM7:TR?= M4j3NnNCVkeHUh?=
CGTH-W-1 NWnJPZUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfCTWM2OD1zLki5PVQ3KM7:TR?= MlT3V2FPT0WU
NB6 M3WycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3vTWM2OD1zLkmxNlk5KM7:TR?= M3;QfnNCVkeHUh?=
EW-22 MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\rbmhKSzVyPUGuPVI5QDdizszN MmTVV2FPT0WU
ES6 NFzQOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTOTWM2OD1zLkmzOlMyKM7:TR?= MmTiV2FPT0WU
SCC-15 NEDU[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vQbGlEPTB;MT65N|gyQSEQvF2= MmjGV2FPT0WU
HL-60 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTkcWt3UUN3ME2xMlk{QTB{IN88US=> M2DtWHNCVkeHUh?=
human HOP-92 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfOeWNKSzVyPUGuPVQxPjVizszN MoLLV2FPT0WU
SW626 M4fqU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwOUS4PVkh|ryP NGPxNolUSU6JRWK=
HEC-1 NYHCZlh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofWTWM2OD1zLkm1N|Yh|ryP NIP3e4lUSU6JRWK=
LB2241-RCC NIfRXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj0W3lKSzVyPUGuPVgzOzFizszN NIrHTVBUSU6JRWK=
Ramos-2G6-4C10 NX\Le3EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L3ZmlEPTB;MT65PVQ6OyEQvF2= MVnTRW5ITVJ?
A101D MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwMkCzNFMh|ryP Mle2V2FPT0WU
NCI-H446 Ml3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\tTWM2OD1{LkC0OVk6KM7:TR?= NWLGNHVKW0GQR1XS
SBC-5 MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJwME[xOFch|ryP NF;ZVVFUSU6JRWK=
HOS MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPtTWM2OD1{LkC3OlU{KM7:TR?= NUf5R2NwW0GQR1XS
K5 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHp[5NKSzVyPUKuNFc5OTFizszN M3jN[nNCVkeHUh?=
HLE M3XpdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorQTWM2OD1{LkC4OVI6KM7:TR?= MXrTRW5ITVJ?
HSC-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfnTWM2OD1{LkGyPFk5KM7:TR?= NV\NZZhoW0GQR1XS
LCLC-97TM1 NFXaTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;UZW5DUUN3ME2yMlE1PTh|IN88US=> M4HiN3NCVkeHUh?=
DMS-273 MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\NUlVKSzVyPUKuNVQ5OzdizszN NGDRcYhUSU6JRWK=
TE-8 MkHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfmdWlKSzVyPUKuNVU4PjVizszN M1PuTnNCVkeHUh?=
DSH1 M3HCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXvfWt{UUN3ME2yMlE3Ozl6IN88US=> NGrSeIhUSU6JRWK=
CAL-51 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXeySI42UUN3ME2yMlE3Pjl7IN88US=> MlS1V2FPT0WU
IST-SL1 NXXMe2xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXwTWM2OD1{LkG2PFQ1KM7:TR?= NYfUdpFRW0GQR1XS
GCT M1;TZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL3TWM2OD1{LkG3O|ch|ryP M1\YbXNCVkeHUh?=
SW948 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\wVWlEPTB;Mj6xPFQ2PiEQvF2= NGDKU|FUSU6JRWK=
NOMO-1 NUDQNGMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHCTWM2OD1{LkG5N|E4KM7:TR?= MkSwV2FPT0WU
C8166 NUjPRmp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwMkGzN|Qh|ryP NGj2RVJUSU6JRWK=
OC-314 M2\vdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTJwMkOyOVkh|ryP MWjTRW5ITVJ?
CAL-39 M1e2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwMkO2NlYh|ryP MofJV2FPT0WU
MDA-MB-453 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfCd4ZKSzVyPUKuNlQzPzVizszN MmC5V2FPT0WU
A673 MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwMkW4OlIh|ryP NHnJco9USU6JRWK=
HTC-C3 M3nqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\RNIVKSzVyPUKuNlY5PSEQvF2= NE\IcZNUSU6JRWK=
NCI-H1666 Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xtd2lEPTB;Mj6yPFEyOSEQvF2= NH3XPFJUSU6JRWK=
PSN1 NVmyNFBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XIfmlEPTB;Mj6yPFkyOyEQvF2= NGrHeFBUSU6JRWK=
GI-1 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfYTWM2OD1{LkOwOVQ{KM7:TR?= NFPsT29USU6JRWK=
HuH-7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJwM{C2N|ch|ryP NE\PTFlUSU6JRWK=
JAR NWTlUldHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG0TWM2OD1{LkOxPVg4KM7:TR?= NX\TVoh{W0GQR1XS
5637 NF\SNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;JTWM2OD1{LkOyNVI6KM7:TR?= MlLhV2FPT0WU
GB-1 NH7hVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2OyfGlEPTB;Mj6zNlM{PSEQvF2= M{C2[HNCVkeHUh?=
KP-N-YS MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfKTWM2OD1{LkOyOlE2KM7:TR?= NIfCSXdUSU6JRWK=
OAW-42 NFPy[mFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3SO25KSzVyPUKuN|M1OTZizszN M1HJfnNCVkeHUh?=
8-MG-BA M4q0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LIbGlEPTB;Mj6zN|kxPiEQvF2= M{WyRnNCVkeHUh?=
RH-18 M2SwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\LTWM2OD1{LkO1NFIzKM7:TR?= M2LX[nNCVkeHUh?=
NCI-H1155 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W2W2lEPTB;Mj6zOlczPSEQvF2= Mn;KV2FPT0WU
NB17 M1TReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLueGhKSzVyPUKuN|gzPDNizszN M2f4WXNCVkeHUh?=
NCI-H1437 NWnveXBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnziTWM2OD1{LkSxPFc{KM7:TR?= NGfKVnhUSU6JRWK=
SN12C MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLDTWM2OD1{LkSzNlE1KM7:TR?= MoXSV2FPT0WU
HSC-3 NYXGSXh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\GTWM2OD1{LkS0OVA6KM7:TR?= MXPTRW5ITVJ?
GAMG NYnmO|lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[5SFRKSzVyPUKuOFQ2PjFizszN NXrEW3dnW0GQR1XS
HT-1080 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJwNES4OlQh|ryP NY\pUWhxW0GQR1XS
A549 NIPN[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XHZmlEPTB;Mj60OFg6OyEQvF2= NVzPV21CW0GQR1XS
KNS-62 NWK2d2d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPZSGJKSzVyPUKuOFUxPjFizszN NUHrSY1UW0GQR1XS
YKG-1 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqxTWM2OD1{LkS1OFM4KM7:TR?= MlPxV2FPT0WU
LU-134-A MmHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;LVXhKSzVyPUKuOFcxODhizszN NIjuVldUSU6JRWK=
FADU MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLSSIFVUUN3ME2yMlQ4OTZ{IN88US=> NInFZWFUSU6JRWK=
TGBC11TKB Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojzTWM2OD1{LkS3NVc4KM7:TR?= NXHRe2djW0GQR1XS
HT-3 NVH1XIk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PYVmlEPTB;Mj60PVU{PSEQvF2= M1vpfXNCVkeHUh?=
NCI-H2170 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwNUC1OFkh|ryP NIDlWJpUSU6JRWK=
Mo-T MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwNUC5Nlch|ryP MnSxV2FPT0WU
CCRF-CEM Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvlT2VsUUN3ME2yMlU{ODR|IN88US=> MorzV2FPT0WU
KU-19-19 NGHWdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJwNUO1NVMh|ryP MkC0V2FPT0WU
NCI-H1048 MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\KS3JKSzVyPUKuOVUxOjVizszN MUPTRW5ITVJ?
KOSC-2 Ml7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPJZVFKSzVyPUKuOVYxPzZizszN MnPDV2FPT0WU
A431 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLN[5RKSzVyPUKuOVY{OzVizszN NUO1cHBHW0GQR1XS
COR-L23 NIjkSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwNUi1OlYh|ryP NEC0NIVUSU6JRWK=
MKN28 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJwNUmwN|ch|ryP M4LJeHNCVkeHUh?=
22RV1 NFLuVpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjFdIxvUUN3ME2yMlU6Ojd2IN88US=> NX;OW2JMW0GQR1XS
ABC-1 NVzzeW9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfwd|R6UUN3ME2yMlYxPDZizszN NFfQRVJUSU6JRWK=
NCI-H2126 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\aU2lEPTB;Mj62NFk5PCEQvF2= MVvTRW5ITVJ?
DoTc2-4510 M2LxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPjeHdKSzVyPUKuOlIyQDVizszN M4Lj[HNCVkeHUh?=
SCC-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDPRlkzUUN3ME2yMlY{ODF{IN88US=> MmLjV2FPT0WU
NCI-H661 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJwNkSwPFUh|ryP MXXTRW5ITVJ?
RPMI-2650 NYO0O3lLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zGcWlEPTB;Mj62OFE1OyEQvF2= NYrsRVlJW0GQR1XS
NCI-H510A NY\YVYVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjtSVFKSzVyPUKuOlQ1OjZizszN NF23R|FUSU6JRWK=
BPH-1 M1mzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfydJV4UUN3ME2yMlY2QDVizszN MlfOV2FPT0WU
M14 NFPNUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPhTnNXUUN3ME2yMlY3QTl|IN88US=> M1ztT3NCVkeHUh?=
G-402 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;1eI1[UUN3ME2yMlcxPDVzIN88US=> M{HYU3NCVkeHUh?=
AsPC-1 NVu2SpJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrKTVFKSzVyPUKuO|EyPyEQvF2= NWT1bFNMW0GQR1XS
NB12 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli2TWM2OD1{LkexO|Eh|ryP M1KySnNCVkeHUh?=
SK-HEP-1 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HT[WlEPTB;Mj63OFM6OSEQvF2= MoTYV2FPT0WU
U-266 MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXntdmNzUUN3ME2yMlc4OTJzIN88US=> M2DDcXNCVkeHUh?=
AM-38 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[wTWM2OD1{Lke3N|U2KM7:TR?= M2rmcnNCVkeHUh?=
PC-14 MkPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;yW4FIUUN3ME2yMlgxPTFizszN NYC2PYtZW0GQR1XS
EGI-1 NXjaTVBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjjZoNKSzVyPUKuPFE4PDNizszN NXr0[mJZW0GQR1XS
LS-411N MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\ifGlEPTB;Mj64NlM{KM7:TR?= NF;R[VJUSU6JRWK=
BFTC-905 NW\4dWZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHtO|BUUUN3ME2yMlg2PTJ|IN88US=> NVnsT3BqW0GQR1XS
CaR-1 NXHGbpBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTRTWM2OD1{Lki2JO69VQ>? NXnUbolPW0GQR1XS
NCI-H292 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3vTWM2OD1{Lki2OVk3KM7:TR?= NGju[2JUSU6JRWK=
8305C NWLsV3VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDobY1PUUN3ME2yMlg3PjR3IN88US=> NI[0PZVUSU6JRWK=
SNU-449 NUD4R4RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rwdGlEPTB;Mj64PVE5OiEQvF2= NYW5eZA4W0GQR1XS
LCLC-103H MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LuU2lEPTB;Mj65NFQ{QCEQvF2= MnHwV2FPT0WU
SW1573 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJwOU[wPFIh|ryP MmWwV2FPT0WU
MLMA Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPOTWM2OD1{Lkm2O|E4KM7:TR?= M2X0N3NCVkeHUh?=
NCI-H1355 NHfSfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNwMEC3PVYh|ryP MYnTRW5ITVJ?
RMG-I NW\EOnhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLwPWpKSzVyPUOuNFI2QTJizszN MYHTRW5ITVJ?
BB65-RCC NEnnWVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1S4cWlEPTB;Mz6wN|MyPCEQvF2= M{DtfXNCVkeHUh?=
PC-3 NH\UdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTNwMEO4O|Qh|ryP M2fSdnNCVkeHUh?=
SF268 NX3kUmZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXwTHl6UUN3ME2zMlA1PTJ|IN88US=> MW\TRW5ITVJ?
NCI-H810 M3fuTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfKTWM2OD1|LkC0PFI{KM7:TR?= NVHTR|FRW0GQR1XS
MEG-01 M3vETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\HTWM2OD1|LkC2NVY1KM7:TR?= NVPrdHdsW0GQR1XS
SW13 M33sbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHw[29zUUN3ME2zMlA4QDR5IN88US=> Mo\qV2FPT0WU
RH-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrncYNOUUN3ME2zMlExOjd6IN88US=> MkTmV2FPT0WU
GT3TKB MoP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LqdWlEPTB;Mz6xNVI5OyEQvF2= NFm0XmRUSU6JRWK=
TK10 NUDPTo1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTNwMUO3NlQh|ryP MVXTRW5ITVJ?
T-24 MkHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUSyWZpWUUN3ME2zMlE2ODdizszN NGTjNpNUSU6JRWK=
A498 M3;kdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\UbWxTUUN3ME2zMlIxQDdzIN88US=> MlfhV2FPT0WU
GR-ST MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGyfHpKSzVyPUOuNlIyOzlizszN NV;xR25zW0GQR1XS
LB2518-MEL M3LUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnKTm9KSzVyPUOuNlI{QThizszN MYLTRW5ITVJ?
T47D M1vxNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHuN4xKSzVyPUOuNlM3OjdizszN M3XWTXNCVkeHUh?=
NCI-H1651 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjCb|ZKSzVyPUOuNlQ3PDRizszN NW\TSotlW0GQR1XS
EC-GI-10 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTNwMk[xOVMh|ryP MlPuV2FPT0WU
HT-29 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT0TWM2OD1|LkK2OlE1KM7:TR?= MkC5V2FPT0WU
GI-ME-N NFT2[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHyzeVJKSzVyPUOuNlk2OTFizszN MkLkV2FPT0WU
SW756 NFuxcYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3CSlBPUUN3ME2zMlI6PjJ7IN88US=> NX3CXYF6W0GQR1XS
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NCI-H1563 NVeyfpNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvzS2xsUUN3ME2zMlM{ODF6IN88US=> MkDmV2FPT0WU
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NCI-H596 NULnVVlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJ|LkmwOVUh|ryP M3nydXNCVkeHUh?=
MZ1-PC Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPXR4RQUUN3ME2yOE43PzV7IN88US=> NFHsdI5USU6JRWK=
SW1417 NXu5S|FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJ3LkK0PVgh|ryP M3vVO3NCVkeHUh?=
NCI-H82 MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJ4LkSyPFgh|ryP M2jHN3NCVkeHUh?=
COLO-678 NXH5eI9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ5LkS5NVkh|ryP MmXsV2FPT0WU
KURAMOCHI NWKwXotbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jsb2lEPTB;MkiuNVI3KM7:TR?= NY\kWosxW0GQR1XS
NCI-H1650 M3HUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r4TGlEPTB;M{CuNVkzPCEQvF2= MX3TRW5ITVJ?
HCC1954 NH;ZWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTNzLkO2OlYh|ryP NXfHblVUW0GQR1XS
GAK MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjHWmVqUUN3ME2zNk4zPjF4IN88US=> MXrTRW5ITVJ?
YAPC MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnDTWM2OD1|Mz63OlQ5KM7:TR?= MlPXV2FPT0WU
NCI-H2228 NVTRSVFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLHTWM2OD1|ND6zOlA2KM7:TR?= NGO2VoZUSU6JRWK=
VMRC-RCZ MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjYSZFwUUN3ME2zOk4{ODJ{IN88US=> MlzpV2FPT0WU
NMC-G1 NGWyNHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rkWGlEPTB;M{euNFUzQSEQvF2= M4Tvd3NCVkeHUh?=
D-336MG M17xcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGq4eYtKSzVyPUSxMlg1PDJizszN M3HDRXNCVkeHUh?=
UACC-62 NWrOfnJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MniwTWM2OD12Mj61OVA2KM7:TR?= Mkj6V2FPT0WU
C-33-A MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXryWXBbUUN3ME20OU4{OjV4IN88US=> NXHVRlkyW0GQR1XS
HCC1937 NHz3O2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvTO5hGUUN3ME20O{4yQTV6IN88US=> NIX6TmdUSU6JRWK=
HDLM-2 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPYWXRyUUN3ME20O{4zOjh5IN88US=> NFnNZ5dUSU6JRWK=
NCI-H727 Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnWTWM2OD12Nz6yOFUyKM7:TR?= M3nJTHNCVkeHUh?=
NY MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ezRmlEPTB;NEmuN|kxQCEQvF2= NWO0XVQ6W0GQR1XS
NCI-H2291 NY\EPXNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm2TWM2OD12OT64N|AyKM7:TR?= NWX3XIlFW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Water Insoluble
Ethanol ''3 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms MK0683
Smiles C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

In vivo Formulation Calculator (Clear solution)

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Withdrawn Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID