Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 259 Publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MlrGT4lv[XOnIFHzd4F6 Mnm4NUBp MonRSG1UVw>? M4rXd4FvfGlvSFTBR|Eh[WO2aY\peJkhf2m2aDDJR|UxKG:oIECuNVEzKM7:TR?= MYmxNVk3ODR6OR?=
Friend leukemic cell NGi0NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO0b|RPPTBizszN M1G2[lczKGh? MljYSG1UVw>? MlTNTWM2OD1yLkm5JO69VQ>? M{T6SFEzOTB7OUGz
K562 NHjTV2NMcW6jc3WgRZN{[Xl? M1yyVlYhcA>? NYq4cGo3TE2VTx?= NUHC[HRCUW6qaXLpeIlwdiCxZjDoeY1idiCqaYP0c45mKGSnYXPleJlt[XOnIDjtbZh1fXKnIH;mJGhFSUNzIHHu[EBJTEGFMjmge4l1cCCLQ{WwJI9nKDBwMEGg{txO NHm0dmYyOjRzOUO4NC=>
HT1080 M4D1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nYRlczKGh? NHLNcWlFVVOR NVH1U5hsUUN3ME2yMlQh|ryP MlXGNVIzPzBzN{W=
H1299 NYLqRXVSU2mwYYPlJGF{e2G7 MYiyNEBucW5? MmnMSG1UVw>? MoDzTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= M4fZbFE1PTJzNEKy
H1299 M{jUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TsR|czKGh? MUfEUXNQ NXXtcmVOUUN3ME23MlI1KM7:TR?= NEHjT3AyPDV{MUSyNi=>
HeLa NVS4OG1PU2mwYYPlJGF{e2G7 MVSzNEBucW5? M3;5[WlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO NEfvXWIyPTZyM{m0PS=>
LOX-IMVI M4X0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU[0PEBp MmTwTWM2OD1zLkOg{txO NFjjZXMyPTdzNUS3NC=>
NCI-H226 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzmcHQ1QCCq NIHyZZZKSzVyPUKuOkDPxE1? NHvpR4gyPTdzNUS3NC=>
RXF-631L MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HJWFQ5KGh? MWDJR|UxRTJizszN NFnx[HYyPTdzNUS3NC=>
SNB-78 NVP2c5JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK4NlY1QCCq NHTvd3BKSzVyPUG2JO69VQ>? NF\je|MyPTdzNUS3NC=>
St-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWm0PEBp NFXI[|hKSzVyPUWuNkDPxE1? M{m4Z|E2PzF3NEew
ARP1 M3vLXmZ2dmO2aX;uJGF{e2G7 MlX4NkDPxE1? MkXROkBp NGrFOpJKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MXKxOFc{PDhyNh?=
CEM MVnLbY5ie2ViQYPzZZk> MVGxJIg> NYXZdFNKTE2VTx?= M3vpSGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? NWfuN3g{OTZ2MkCwOlQ>
HCT15 NFvPbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXK0PEBp M4fGcWdKPTB;MD64NkDPxE1? M3q0UFE3PzJ|MkK3
NCI-H23 NXfpRmp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX20PEBp M1fvfmdKPTB;MD65NkDPxE1? NV3nR2VDOTZ5MkOyNlc>
GM15850 NVz0XpRmU2mwYYPlJGF{e2G7 NV;zfnpjOi53IN88US=> NYjVZW1qQTZiaB?= NY\WS2lnTE2VTx?= MWrJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKMzDsfZNqdmViMUSgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NWXwR5hQOTZ7MkGzOlc>
GM15850 NVTsVnN5U2mwYYPlJGF{e2G7 MX2yMlUh|ryP M2nUV|k3KGh? NVfRbndWTE2VTx?= MoW0TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MUixOlkzOTN4Nx?=
GM15850 M4XFWGtqdmG|ZTDBd5NigQ>? MmSyNk42KM7:TR?= M1nkS|k3KGh? M4rsVGROW09? NEjGeWhKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NULhU4N3OTZ7MkGzOlc>
GM15850 M1L1[2tqdmG|ZTDBd5NigQ>? MonkNk42KM7:TR?= MoHVPVYhcA>? NEnER2RFVVOR NInNbGxKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MWKxOlkzOTN4Nx?=
GM15850 MkGyT4lv[XOnIFHzd4F6 MVKyMlUh|ryP MWW5OkBp MYrEUXNQ NWrZOphSUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFgh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NXf2XnA1OTZ7MkGzOlc>
GM15850 NXTuPHNMU2mwYYPlJGF{e2G7 M{HrW|IvPSEQvF2= NV3PcpIyQTZiaB?= MnezSG1UVw>? NVruXGcyUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MoWyNVY6OjF|Nke=
U937 MoTHSpVv[3Srb36gRZN{[Xl? NF7FdI82KM7:TR?= MkjnNlQhcA>? MX;EUXNQ MX3D[YxtKGO7Y3zlJIFzemW|dDDifUBi[2O3bYXsZZRqd25iYYSgV{9IOi:PIIDoZZNm NGTWbnEyPzByNEexPC=>
H661 NGXac3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6xXZZ[PDhiaB?= M3zmc2lEPTB;MTFOwG0> Mlm1NVcyPTdyMEm=
U937 NHTvd5VHfW6ldHnvckBCe3OjeR?= NV\ISGR1PSEQvF2= NH;GWnkzPCCq NXfPOFUxTE2VTx?= M2LkPGlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= MX:xO|Q1Pzd3MB?=
U937 NGCybnlHfW6ldHnvckBCe3OjeR?= MlrQNUDPxE1? MoDZNlQhcA>? MmjUSG1UVw>? MYfF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= MUGxO|Q1Pzd3MB?=
RAW264.7 MoO4SpVv[3Srb36gRZN{[Xl? MVuxNEDPxE1? Mlu4NlRp MVv3ZZRmeg>? MmfQTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBVVk[jbIDoZUBxem:mdXP0bY9vKHerdHigTWM2OCCxZjCwMlc3KM7:TR?= MVyxO|Q4PzVzOB?=
RAW264.7 M2XFemZ2dmO2aX;uJGF{e2G7 NYW0ZVU{OTBizszN NGLRVY8zPGh? MXv3ZZRmeg>? M1T6T2lvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhVk9icILv[JVkfGmxbjD3bZRpKEmFNUCgc4YhOS56ODFOwG0> NHfnUnkyPzR5N{WxPC=>
SC9 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTid2ZqPDhiaB?= NIrZSWlKSzVyPUCuOlA3KM7:TR?= NGnG[Y4yPzVyN{KxPS=>
ST14A M33YSGZ2dmO2aX;uJGF{e2G7 MX[1JI5O NUDwZ4dyPzJiaB?= NYXTXYFxUW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? NXXNTZJ3OTd3NkW5PVM>
ST14A M2jWemZ2dmO2aX;uJGF{e2G7 M1j1V|Uhdk1? MmTEO|IhcA>? NHu3UnhKdmO{ZXHz[UBqdiCHMl[xJI1TVkFiZYjwdoV{e2mxbh?= MnPTNVc2PjV7OUO=
PANC1 M17NVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X5NVEh|ryP M4HldmlEPTB;MD60OUDPxE1? M{TLUVE4PTh6N{S0
PANC1 M3i1UWZ2dmO2aX;uJGF{e2G7 M3r5[lEh|ryP M{L6TFI1KGh? M1XZZWlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? NWnESFNjOTd3OEi3OFQ>
PANC1 NXvONm1iTnWwY4Tpc44hSXO|YYm= NGrieYoyKM7:TR?= NHvWfJMzPCCq Mn;iTY5kemWjc3WgbY4heDJ5a3nwNUBo\W6nIHX4dJJme3Orb36= M1rRelE4PTh6N{S0
PT45 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[0TWM2OD12IN88US=> Ml7sNVc2QDh5NES=
ACHN M1ftN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWxOWhWOjFiaB?= NH\nPJdIUTVyPUCuOlUh|ryP MYmxO|Y3OjZyNh?=
PC3 NFv6[YNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;Yd2kzOSCq NV\MRWlOT0l3ME2wMlcyKM7:TR?= NGfIeJYyPzZ4Mk[wOi=>
A431 NVnhU5R2S3m2b4TvfIlkKEG|c3H5 MnflO|IhcA>? MmGyTWM2OD12LkKg{txO NFTQV3kyPzZ7MUe2Ny=>
Cal27 M{W3SGN6fG:2b4jpZ{BCe3OjeR?= MmjlO|IhcA>? NGq5SHdKSzVyPUOuNkDPxE1? MVqxO|Y6OTd4Mx?=
CCRF-CEM M{jDWmN6fG:2b4jpZ{BCe3OjeR?= NIrGXY44OiCq NF;MOZhKSzVyPUCuPEDPxE1? M4mxblE4PjlzN{[z
EOL1 MnWzR5l1d3SxeHnjJGF{e2G7 M3X4PFczKGh? NFfBcVJKSzVyPUGg{txO MknxNVc3QTF5NkO=
Hec-1-A M1LQWGN6fG:2b4jpZ{BCe3OjeR?= NUnWbG1FPzJiaB?= M37BOWlEPTB;MTFOwG0> NYnuVI5uOTd4OUG3OlM>
HeLa MVfLbY5ie2ViQYPzZZk> MVmxNEDPxE1? MUmzNEBucW5? M1TBVGROW09? NIXMZoRKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGhFSUNzIIfpeIghUUN3MDDv[kAxNjB{IN88US=> MYKxO|Y6OTd4Mx?=
RKOp21 M2nTUGN6fG:2b4jpZ{BCe3OjeR?= M2f5c|czKGh? MYHJR|UxRTFwN{[g{txO MX6xO|Y6OTd4Mx?=
Saos2 M4HKe2N6fG:2b4jpZ{BCe3OjeR?= MYW3NkBp Mlf2TWM2OD1{LkOg{txO MkjrNVc3QTF5NkO=
SK-OV-3 MXjDfZRwfG:6aXOgRZN{[Xl? M4PrRVczKGh? Mmf3TWM2OD1{LkKg{txO NUL5eHZbOTd4OUG3OlM>
U87MG NFTOU|JEgXSxdH;4bYMhSXO|YYm= NF3p[pQ4OiCq MoLYTWM2OD1zMTFOwG0> NI\RVGoyPzZ7MUe2Ny=>
NUGC3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fjdFUh|ryP MmLHNlQhcA>? NXTFUFBnT0l3ME2yMlc6KM7:TR?= NHSyPHcyPzlyNEi0Ny=>
CCD1059SK MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{Szd2lEPTB;NEOuOUDPxE1? MnHGNVgzPDd3NUS=
HepG2 NF7vOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jNfmlEPTB;MD6wNFA3KM7:TR?= MYOxPFI1PzV3NB?=
HT1080 NGjPRWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3CTWM2OD1yLkCwNlQh|ryP MVKxPFI1PzV3NB?=
SKBR3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fpc2lEPTB;MD64JO69VQ>? MkPSNVgzPDd3NUS=
SNB78 NF3WPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\vTGVEPTB;MU[g{txO NHriRVMyQDJ2N{W1OC=>
SQ20B MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTNizszN NV\pT2M2OTh{NEe1OVQ>
St4 NVqxXWtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH2SWM2OD13LkKg{txO MUSxPFI1PzV3NB?=
MCF7 NYLu[FRVTnWwY4Tpc44hSXO|YYm= NYHKemZtOTBizszN NVjlc4p{QCCq NWLxXYJYTE2VTx?= M{T5[Wlv\HWldHnvckBw\iC2dXL1cIlvKGi7cHXyZYNmfHmuYYTpc44> M{HFSVE5OjZ7MkK2
HEK293 NX;hUJdFU2mwYYPlJGF{e2G7 NFSyZmwyKGh? MYXEUXNQ MYHJcohq[mm2aX;uJI9nKEiGQVOxJJdqfGhiSVO1NEBw\iByLkCzJO69VQ>? NY\mdGt[OTh|MEi1OlM>
HEK293 NFW0fWxMcW6jc3WgRZN{[Xl? NG\5[HgyKGh? NFK1VGlFVVOR MYnJcohq[mm2aX;uJI9nKEiGQVOzJJdqfGhiSVO1NEBw\iByLkC1O{DPxE1? MV6xPFMxQDV4Mx?=
G401 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\CO|IhcA>? M{nTOGROW09? M1rmS2lEPTB;MTFOwG0> MmH4NVg{PzB|N{O=
HeLa M4W0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVW3NkBp MUTEUXNQ NWLmSm9yUUN3ME2wMlQ3KM7:TR?= MYOxPFM4ODN5Mx?=
Human renal epithelial cell NWLLV4JnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jwOFczKGh? M{DiZWROW09? M{KzVmlEPTB;MUSg{txO MX6xPFM4ODN5Mx?=
U937 NI\rb5lHfW6ldHnvckBCe3OjeR?= Mn:3OUDPxE1? NF:yXFEzPCCq MVXJcoR2[3Srb36gc4YhcGm|dH;u[UBJPCCqeYDldoFk\XS7bHH0bY9v MVyxPFM5OTJ|OB?=
U937 M4ftcmZ2dmO2aX;uJGF{e2G7 M12wdVUh|ryP M1H2Z|I1KGh? MXXJcoR2[3Srb36gc4Yh[WyyaHGgeJVjfWyrbjDofZBmemGlZYT5cIF1cW:w NH\2NI8yQDN6MUKzPC=>
U937 NGL3[YpHfW6ldHnvckBCe3OjeR?= NI[wenc2KM7:TR?= MUmyOEBp NH3HTGdKdmS3Y4Tpc44hd2ZicEKxJIV5eHKnc4Ppc44> M2TkPVE5OzhzMkO4
U937 NGnSSI9HfW6ldHnvckBCe3OjeR?= NVq5cY5[PSEQvF2= NXv2U|FzOjRiaB?= M2G5XWlv\HWldHnvckBw\iCjcH;weI9{cXN? NXjrWpdVOTh|OEGyN|g>
U937 MYXGeY5kfGmxbjDBd5NigQ>? MWO1JO69VQ>? NWj5[JdKOjRiaB?= M4r5eGlv\HWldHnvckBw\iCpcnHueYxw[3m2aXOg[Iln\mW{ZX70bYF1cW:w NFv2OWwyQDN6MUKzPC=>
U937 NFjEe4RMcW6jc3WgRZN{[Xl? NELlS4I2KM7:TR?= MnfaNlQhcA>? NVjD[Gl2UW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDNS=> NIXkdGUyQDN6MUKzPC=>
U937 MkmzT4lv[XOnIFHzd4F6 MUS1JO69VQ>? NWPVW5RPOjRiaB?= NVrmOGpRUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDOC=> MWixPFM5OTJ|OB?=
HEK-TE NGf3RnRHfW6ldHnvckBCe3OjeR?= MYq1JO69VQ>? MXK2bC=> NGrmRpdFVVOR Mn7ZTY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= M3zNelE5PDN2MUS0
HPDE6c7 NEnWVZVEgXSxdH;4bYMhSXO|YYm= MWW1NEDPxE1? MWe3NkBp MnnhSG1UVw>? Ml7UTWM2OD1zLkOg{txO M2nwXFE5PDl2NE[z
Human microvascular epithelial cell NFXndJhEgXSxdH;4bYMhSXO|YYm= NFvxZo02OCEQvF2= MofPO|IhcA>? MVHEUXNQ M4\yOWlEPTB;MT6zJO69VQ>? NHnpVpAyQDR7NES2Ny=>
Hup T3 MX3DfZRwfG:6aXOgRZN{[Xl? NYXLe3F1PTBizszN MWS3Nog> MYDEUXNQ Mm\nTWM2OD1yLkig{txO MXexPFQ6PDR4Mx?=
Mia Paca2 M{P1UmN6fG:2b4jpZ{BCe3OjeR?= M1PmPFUxKM7:TR?= NV[wdm9KPzKq M1HpfGROW09? NGfodmpKSzVyPUGuNUDPxE1? M4PPfVE5PDl2NE[z
Panc 04.03 MojRR5l1d3SxeHnjJGF{e2G7 NV[1[m55PTBizszN M3flblczcA>? NF;0UmZFVVOR M2DqUmlEPTB;MT6yJO69VQ>? NVS2VXd1OTh2OUS0OlM>
SU 86.86 MmHSR5l1d3SxeHnjJGF{e2G7 M2DTSlUxKM7:TR?= NYjGcYZ7PzKq NUj3WJV{TE2VTx?= NFrhd3FKSzVyPUGuN{DPxE1? M4TtR|E5PDl2NE[z
HEK293 NVHjfnJ6U2mwYYPlJGF{e2G7 MoG3N{Bp M1HpVGlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgTGRCSzZiZYjwdoV{e2mxbjD3bZRpKEmFNUCgc4YhOC5yMUmg{txO NX;XfY81OTh3NUi2Olk>
HeLa Mmj1T4lv[XOnIFHzd4F6 NWDFToY2OiCq NUm5PHJqUW6qaXLpeIlwdiCxZjDueYNt\WG{IFjERWMhf2m2aDDJR|UxKG:oIECuNFg{KM7:TR?= NV\3NHduOTh3NUi2Olk>
RAW264.7 MVrGeY5kfGmxbjDBd5NigQ>? MlHDNkDPxE1? M1XwdVMvPSCq NYDpeoFUTE2VTx?= MkP3RY51cW2jbHHybYFtKGGldHn2bZR6KGGpYXnud5QhWGyjc33v[Il2dSCoYXzjbZBienWvIHnu[oVkfGWmIIfpeIghUUN3MDDv[kAxNjFzIN88US=> NEmwV28yQDZ2NEm2PS=>
NB4 M1nMVFQ5cA>? NGHubplFVVOR NVLzW41jUUN3ME2wMlYh|ryP NGjGOIIyQDd{M{O0PS=>
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Sf21 NY\hbFVlU2mwYYPlJGF{e2G7 NFfYXnM{KGh? M3zZXWlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN M3Ty[VIyODhyNkK5
SKBR3 NETPPZdEgXSxdH;4bYMhSXO|YYm= NUjDW3F7PzJiaB?= NHjSSFNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTVJ{IIfpeIghUUN3MDDv[kAzNjZizszN NWTrV3l1OjFyOEC2Nlk>
SKOV3 Ml;sR5l1d3SxeHnjJGF{e2G7 MlfyO|IhcA>? MlP2R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= M1vaelIyODhyNkK5
COR-L23 MoLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnP6NVAh|ryP MXm3NkBp NE\5UHFFVVOR MVvHTVUxRTFwMTFOwG0> NULPOXRkOjFyOEC2OFc>
DU145 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HmSlExKM7:TR?= MUm3NkBp MXnEUXNQ NETaNpJIUTVyPUGuNFUh|ryP M{m5c|IyODhyNkS3
LoVo M{ntc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;oNGp2OTBizszN MoPXO|IhcA>? NHrJV4xFVVOR M2C0TmdKPTB;MT63JO69VQ>? MkC1NlExQDB4NEe=
MCR5-SV2 NYTZdXNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3mSZMyOCEQvF2= NFv0XFU4OiCq M1K0[GROW09? MYDHTVUxRTJwMTFOwG0> MWCyNVA5ODZ2Nx?=
HCT116 M3O5UmtqdmG|ZTDBd5NigQ>? NWrzZmhyOzBizszN M2HLNVMxKGh? MWXEUXNQ MVHJcohq[mm2aX;uJI9nKEiGQVO2JIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDhcJBp[S22dXL1cIlvKGGlZYT5cIF1cW:w Ml7INlExQDB4NEe=
HCT116 M3H2[mtqdmG|ZTDBd5NigQ>? NGO2NXY{OCEQvF2= NUf1VpoxOzBiaB?= MXPEUXNQ NVzsZWdPUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u NXX2eJdZOjFyOEC2OFc>
U937 MW\LbY5ie2ViQYPzZZk> NEf5VVA2KM7:TR?= MkTPNlQhcA>? NEiwenFFVVOR NFTVZXhKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNOR?= M{fpcVIyOjl{NEmy
U937 MoXvT4lv[XOnIFHzd4F6 M3rzc|Uh|ryP NETpNGczPCCq MVzEUXNQ NG\oW|lKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4Yh[WOndInsZZRqd25ib3[gbIl{fG:wZTDIN{BifCCNMUi= MXSyNVI6OjR7Mh?=
U937 NIG4bmNMcW6jc3WgRZN{[Xl? NHLrTVc2KM7:TR?= NUHmSZVxOjRiaB?= NGfEdGxFVVOR NGXBeHJKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= MYWyNVI6OjR7Mh?=
U937 MUDLbY5ie2ViQYPzZZk> NWTpToR5PSEQvF2= NHexbHMyPSCvaX6= MWLEUXNQ NYjlSodPUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGirc4TvcoUhUDNiYXPleJlt[XSrb36gcIV3\Wx? MmG0NlEzQTJ2OUK=
A2780 NHrBdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfJU4N2QTZiaB?= NEfyZXlFVVOR NYr0Z3pOUUN3ME2xMlYzKM7:TR?= MXOyNVY{PDR|MB?=
COLO205 NXPqcG5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjjTmo6PiCq NWm2[3FYTE2VTx?= NVjXOmFGUUN3ME2yMlEzKM7:TR?= NX3USGh6OjF4M{S0N|A>
Hep3B M2jUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjXWoplPDhiaB?= NWX3VY9xTE2VTx?= NG\KXlhIUTVyPUGuNlEh|ryP M2HWSlIyPzF{MUS2
GM11272 NYXPb2FmTnWwY4Tpc44hSXO|YYm= Mmm4NVAxKG6P MYm3NkBp NWTve2R{TE2VTx?= M{HGWXJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> MYeyNVg1ODdzNh?=
CFBE41o MVfLbY5ie2ViQYPzZZk> MXK1JO69VQ>? MVzEUXNQ M2fTWWRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? MXWyNVk5PDl3OB?=
CFBE41o M3SwUWZ2dmO2aX;uJGF{e2G7 MYCxJO69VQ>? NUfrSXdZOjRiaB?= MV3EUXNQ NF;LTmRT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= NV\oSlJpOjF7OES5OVg>
DU145 MkOwT4lv[XOnIFHzd4F6 NHvyXJkzNjVizszN MnjpNlQhcA>? MWPEUXNQ NIn0fY5KdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNidYDy[Yd2dGG2aX;uJI9nKHB{MYfh[lEheHKxdHXpckBmgHC{ZYPzbY9v M13YdVIzOjZyMU[2
DU145 Mk\PT4lv[XOnIFHzd4F6 MmrmOUDPxE1? Mmn5NlQhcA>? NFLQXFdFVVOR Mmn1TY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= Ml;GNlIzPjBzNk[=
DU145 M1XQN2tqdmG|ZTDBd5NigQ>? M3XLclUh|ryP MkPCNlQhcA>? Mny3SG1UVw>? NEnwZ2JKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaHnzeI9v\SCKMzDofZBmemGlZYT5cIF1cW:w NXH6Z2FGOjJ{NkCxOlY>
786-0 M2\Bemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X1dlYvOiEQvF2= NEDubJY4OiCq Ml6wSG1UVw>? M4f2bmdKPTB;Mz6yJO69VQ>? NH2xSpczOjR|NU[2PS=>
A498 M1HpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonKOk4zKM7:TR?= MV[3NkBp MWLEUXNQ M4G1dGdKPTB;MT62JO69VQ>? NFTMOXczOjR|NU[2PS=>
A549/ATCC NVnqdm5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zsWFYvOiEQvF2= NFz3bXk4OiCq MnfSSG1UVw>? NIj0e2lIUTVyPUGuOkDPxE1? M37SUVIzPDN3Nk[5
ACHN NIric|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\SeVRnPi5{IN88US=> MoXPO|IhcA>? M1q5fWROW09? NI\SRo5IUTVyPUGuN{DPxE1? Mn;vNlI1OzV4Nkm=
BT549 NX\JbWI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\SXJg3NjJizszN NGXOU244OiCq M33USWROW09? NFL5cFJIUTVyPUGuN{DPxE1? MnnENlI1OzV4Nkm=
EKVX MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\hR|YvOiEQvF2= MWC3NkBp MkXVSG1UVw>? MnX1S2k2OD1zLkOg{txO MXSyNlQ{PTZ4OR?=
HCT15 M1Hj[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTBVVFTPi5{IN88US=> NH3BU3k4OiCq M2PpdWROW09? NYHqeHUxT0l3ME2yMlUh|ryP NYmwWI41OjJ2M{W2Olk>
HOP92 NFq2bVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX22MlIh|ryP NWLZcpB[PzJiaB?= NXnpUZJsTE2VTx?= M3GwPGdKPTB;NDFOwG0> MWKyNlQ{PTZ4OR?=
IGROV1 NW\xWYh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULXRVBzPi5{IN88US=> NIDQO2Y4OiCq MVTEUXNQ MWfHTVUxRTFwMzFOwG0> MXuyNlQ{PTZ4OR?=
LOXIMVI MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnuwOk4zKM7:TR?= NUXWPGlTPzJiaB?= NWDsWY0zTE2VTx?= MWrHTVUxRTFizszN MmXCNlI1OzV4Nkm=
M14 NELzUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXQSXg3NjJizszN NV34[G1RPzJiaB?= NUjLdG1lTE2VTx?= MmfxS2k2OD1zLkOg{txO MlSzNlI1OzV4Nkm=
MALME-3M NXzId|R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;KS3B4Pi5{IN88US=> NIrO[JI4OiCq M33EemROW09? MYnHTVUxRTBwM{Kg{txO MWmyNlQ{PTZ4OR?=
MCF10A NUm4e3ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknEOk4zKM7:TR?= NV7PN3FlPDhiaB?= NEPr[WpFVVOR MXPHTVUxRTlwNjFOwG0> Mn\LNlI1OzV4Nkm=
MDA-MB-435 M3Ttfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIC0NJA3NjJizszN MV63NkBp Mkm0SG1UVw>? NEXlRmJIUTVyPUCuOUDPxE1? NGiwfFAzOjR|NU[2PS=>
MDA-MB-468 M1nGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL5Ok4zKM7:TR?= NFrm[oM4OiCq NFLNdlhFVVOR NFfadXpIUTVyPUCuOlMh|ryP NVGzNYhLOjJ2M{W2Olk>
MOLT4 M4LRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jnPFYvOiEQvF2= NYq3T5NvPzJiaB?= M2jy[mROW09? M2Hmb2dKPTB;MD60JO69VQ>? NGnMfGozOjR|NU[2PS=>
NCI-ADR-RES MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDBNHI3NjJizszN M1T4R|czKGh? M{m4e2ROW09? MUnHTVUxRTBwMU[g{txO M{eyTVIzPDN3Nk[5
NCI-H23 NFzWPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVO2MlIh|ryP MmfZO|IhcA>? MWDEUXNQ M3m1d2dKPTB;MTFOwG0> MWiyNlQ{PTZ4OR?=
NCI-H322M MnTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvQOk4zKM7:TR?= NFLKd444OiCq NGfDSWJFVVOR MoTwS2k2OD1yLke5JO69VQ>? NW\2VIE{OjJ2M{W2Olk>
NCI-H460 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVi2MlIh|ryP NG\mem84OiCq M4X0eGROW09? MUHHTVUxRTBwN{mg{txO MUSyNlQ{PTZ4OR?=
NCI-H522 MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17MUFYvOiEQvF2= MWS3NkBp NU[yXGcyTE2VTx?= M1nSRWdKPTB;MD61JO69VQ>? M4PpPVIzPDN3Nk[5
OVCAR3 MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HaXVYvOiEQvF2= MX63NkBp NWf5Z5Z6TE2VTx?= NX;IfXo2T0l3ME2xMlMh|ryP MoTtNlI1OzV4Nkm=
OVCAR4 M2Hk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzifJUxPi5{IN88US=> MofhO|IhcA>? M3XqeGROW09? NWTLfolwT0l3ME20JO69VQ>? NVrqZZlDOjJ2M{W2Olk>
OVCAR5 NXztcGtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\oboo3NjJizszN NGPCTGM4OiCq NFftbIRFVVOR M{[zTWdKPTB;MD63PUDPxE1? M2HtVFIzPDN3Nk[5
OVCAR8 MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXVVGE3NjJizszN M3qyfFczKGh? MoT6SG1UVw>? MlLRS2k2OD1yLkWg{txO NVTrOXFjOjJ2M{W2Olk>
RXF393 NFy5eJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv3Ok4zKM7:TR?= NXPCU4tZPzJiaB?= NYjjdJB{TE2VTx?= NELnOGNIUTVyPUGuN{DPxE1? M4PuPFIzPDN3Nk[5
SF268 NXPJfJF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnTd|I3NjJizszN MnLjO|IhcA>? NHGwT4pFVVOR NETQ[YRIUTVyPUGuOkDPxE1? MYiyNlQ{PTZ4OR?=
SF295 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PvVFYvOiEQvF2= NEXLN|c4OiCq MoLDSG1UVw>? NFvWcI5IUTVyPUGuOkDPxE1? M1vTSFIzPDN3Nk[5
SF539 NX7aeIRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPVOk4zKM7:TR?= NGjNOIM4OiCq NIrzfm5FVVOR NXrDSXM5T0l3ME2yJO69VQ>? MUeyNlQ{PTZ4OR?=
SK-MEL-2 NUTZWXBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGqyOXk3NjJizszN NILxfXQ4OiCq NHvxd2JFVVOR MXvHTVUxRTFwMzFOwG0> MlXZNlI1OzV4Nkm=
SK-MEL-28 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrFOk4zKM7:TR?= NYnjXFVVPzJiaB?= NYnMclFLTE2VTx?= Mkf6S2k2OD1zIN88US=> NHrlVFgzOjR|NU[2PS=>
SK-MEL-5 M4nhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;w[|YvOiEQvF2= NGXZdYE4OiCq NEKyNFlFVVOR MmPQS2k2OD1yLk[zJO69VQ>? NWnw[|JzOjJ2M{W2Olk>
SKOV3 NVz3SFAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HEXFYvOiEQvF2= NGCyfm04OiCq MmWzSG1UVw>? M4Hr[GdKPTB;MTFOwG0> MUCyNlQ{PTZ4OR?=
SN12C MkjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUW2MlIh|ryP NH7jZ444OiCq NYTp[2xMTE2VTx?= NXLSUVJbT0l3ME2yJO69VQ>? NETHNngzOjR|NU[2PS=>
SNB19 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[2MlIh|ryP M1XmV|czKGh? NEC4VmdFVVOR MX7HTVUxRTBwNkOg{txO M4j4S|IzPDN3Nk[5
SNB75 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYO2MlIh|ryP MWO3NkBp NH;scHdFVVOR NYXV[HR2T0l3ME2wMlc6KM7:TR?= NX2w[FQzOjJ2M{W2Olk>
SR NYraVYRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnCS45HPi5{IN88US=> NUG5cXh1PzJiaB?= MXjEUXNQ MVfHTVUxRTBwNDFOwG0> M3rjSlIzPDN3Nk[5
T47D NWm5So5NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXW2MlIh|ryP Moi3O|IhcA>? M3rSTWROW09? NYe1S3h5T0l3ME2wMlUh|ryP NVW5WFJbOjJ2M{W2Olk>
TK10 NFXD[2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTDNpRjPi5{IN88US=> NVGxNFN3PzJiaB?= MoTUSG1UVw>? M17pc2dKPTB;MD62N{DPxE1? NG\seFYzOjR|NU[2PS=>
UACC257 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[yelYvOiEQvF2= NHrEbJU4OiCq MkDkSG1UVw>? NU\TTJJkT0l3ME2wMlUh|ryP MonwNlI1OzV4Nkm=
UACC62 NGLiclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW2MlIh|ryP MUO3NkBp MV3EUXNQ NWWzfFFQT0l3ME2wMlQh|ryP MoCyNlI1OzV4Nkm=
UO31 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjsdHA3NjJizszN NX3lflA4PzJiaB?= M4nWfGROW09? Mn7CS2k2OD1yLkWg{txO M17qRlIzPDN3Nk[5
Hep3B NH\UWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rVPVQ5KGh? NVXNO4tUTE2VTx?= MmXZS2k2OD1yLk[5JO69VQ>? MoX0NlI1Ozl6NkO=
BE(2)-C NGfm[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWO3NkBp MXzEUXNQ M4X3VmlEPzB;MjFOwG0> NEPTWIQzOjl|MkOxOi=>
Bel7402 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu5bHJSPzJiaB?= Mom0SG1UVw>? MXjHTVkxRTF5IN88US=> NYqxWJFzOjNyNkGzO|Y>
Bel7404 NF34R3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT5TJBRPzJiaB?= MkjPSG1UVw>? NEjZb|VIUTlyPUG4JO69VQ>? NYG5TpR1OjNyNkGzO|Y>
BGC823 NHP5d4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Pp[VczKGh? MUHEUXNQ NIXIdJJIUTlyPUeuOUDPxE1? NFjIWY0zOzB4MUO3Oi=>
MGC803 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PLbVczKGh? NIXPSWxFVVOR MnjlS2k6OD1zMD64JO69VQ>? NXHST453OjNyNkGzO|Y>
SGC7901 NFX4NHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHqyT4I4OiCq MUDEUXNQ MV;HTVkxRTlwNDFOwG0> NFrwRVgzOzB4MUO3Oi=>
SKHEP1 NGXvU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfOTYk4OiCq MmDKSG1UVw>? M4qxd2dKQTB;MUeg{txO MUGyN|A3OTN5Nh?=
SMMC7721 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYC3NkBp MVXEUXNQ NF;ISm5IUTlyPUKwJO69VQ>? MnvMNlMxPjF|N{[=
NUGC3 NIP0V|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG4cnkyOTBizszN Mn[5S2k:Oi57NDFOwG0> NFizU4wzOzF4M{OzNi=>
A2780 CisR M3ryc2tqdmG|ZTDBd5NigQ>? NUm0W5pOOThiaB?= NHXvSYZKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOFQh|ryP NXzhVXJ6OjN{NUK2NFM>
CAL27 sens MmDkT4lv[XOnIFHzd4F6 MkfpNVghcA>? Mnv5TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkO2JO69VQ>? MoTrNlMzPTJ4MEO=
CAL27 CisR MVnLbY5ie2ViQYPzZZk> NFW5TGIyQCCq MoO5TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NUSzRVhwOjN{NUK2NFM>
KYSE-510 CisR MUDLbY5ie2ViQYPzZZk> NHSwdHAyQCCq M2K3c2lvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD61PUDPxE1? MU[yN|I2OjZyMx?=
KYSE-510 sens MX;LbY5ie2ViQYPzZZk> MVSxPEBp M4DiTGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? NV;xXXpSOjN{NUK2NFM>
MDA-MB-231 sens MXrLbY5ie2ViQYPzZZk> MYSxPEBp NFjQSZFKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP MlLDNlMzPTJ4MEO=
MDA-MB-231 CisR MWrLbY5ie2ViQYPzZZk> MmfuNVghcA>? Ml\vTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? NVHwWVNVOjN{NUK2NFM>
ES2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK0OFghcA>? MYPEUXNQ NWHu[25GUUN3ME2xNk44KM7:TR?= NYLpcW9bOjN2OUO0OFk>
MDA-MB-231 M{P3[WtqdmG|ZTDBd5NigQ>? M3W0NlExKM7:TR?= M{nxNFMxKG2rbh?= NEGz[WFFVVOR MoSzTY5pcWKrdHnvckBw\iCKRFHDNoE> Mn\VNlM1QTN2NEm=
MDA-MB-231 MX;LbY5ie2ViQYPzZZk> NHn5ZYEyKM7:TR?= NUTYN4I6OjRiaB?= Mn3GSG1UVw>? NX\VbJhCUW6qaXLpeIlwdiCxZjDISGFEPiCjc4Pld5Nm\CCjczDhZ4V1gWyjdHnvckBt\X[nbIOgc4YhfHWkdXzpci=> NUi4cHJUOjN2OUO0OFk>
HS68 NVfFN5NpS3m2b4TvfIlkKEG|c3H5 M4nl[FExKM7:TR?= MVi3NkBp NE[yUIFFVVOR MYDJR|UxRTRwNjFOwG0> NXq2NFZLOjN3N{C1OFI>
MEF NXPZV5dWS3m2b4TvfIlkKEG|c3H5 NWXP[GlHOTBizszN NFz3b244OiCq MmDmSG1UVw>? MX\JR|UxRTRwNDFOwG0> MWeyN|U4ODV2Mh?=
BGC823 NYP3PYlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr6SG1UVw>? M3fyVmdKPTB;Mz6wPUDPxE1? MVmyN|YxOTdyNh?=
High5 M3TpOGtqdmG|ZTDBd5NigQ>? M3jWSFI1KGh? M{jLUmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Yhf2m2aDDJR|UxKG:oIECuNFkh|ryP M2LYdFI{PjB{NUKz
High5 NXXqXmFsU2mwYYPlJGF{e2G7 MX6yOEBp M4HhPGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiSFTBR|Ehf2m2aDDJR|UxKG:oIECuNVIh|ryP Ml7ZNlM3ODJ3MkO=
High5 Ml71T4lv[XOnIFHzd4F6 NFXQXpczPCCq MV7Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? Mo\iNlM3ODJ3MkO=
A549 M{C3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jGcmROW09? MY\JR|UxRTFwMEe5JO69VQ>? NYfDXpNCOjN4NESyNVA>
HCT116 NYPJRmJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWwSG1UVw>? NH;idlZKSzVyPUCuO|U4KM7:TR?= NYPucXZFOjN4NESyNVA>
K562 M{XBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TtNWROW09? NVLaOJFnUUN3ME2wMlY1PSEQvF2= NEjyO2ozOzZ2NEKxNC=>
GBC-SD NEXhVZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoWxOUDPxE1? NUjoTYw3PzJiaB?= M2TnbGROW09? MWXJR|UxRTF2Lkig{txO MWCyN|cxPzJ4MB?=
HGC27 MofZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYO1JO69VQ>? M33RTlczKGh? MV7EUXNQ NF[zRpVKSzVyPUWuOEDPxE1? Mkm1NlM4ODd{NkC=
HL60 NGnMfFFMcW6jc3WgRZN{[Xl? M2DJVlUh|ryP MnToNlQhcA>? M1HkTWROW09? MWnJcohq[mm2aX;uJI9nKEiGQVO= MUSyN|cxPzJ4MB?=
Vero M2H2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjNd5A4OiCq MlX1SG1UVw>? MXHJR|UxRTBwOTFOwG0> M{XXd|I{Pzh4NEWy
NCI60 MXfDfZRwfG:6aXOgRZN{[Xl? NYizfoduPDhiaB?= NE\5dnVFVVOR NFuxcXRIUT1yLkWzJO69VQ>? NVPqW4FGOjRyMUWzNlc>
SW620 M3\semN6fG:2b4jpZ{BCe3OjeR?= M3XoblQ5KGh? NF;hSFZFVVOR M{LKdGdKRTBwNUSg{txO NIXvSHgzPDBzNUOyOy=>
U251 NGn2N5lEgXSxdH;4bYMhSXO|YYm= MkfoOFghcA>? M{HnOGROW09? M2[wT2dKRTFwNUOg{txO MonWNlQxOTV|Mke=
KM12 MYjDfZRwfG:6aXOgRZN{[Xl? NHG1XFY1QCCq M324TmROW09? NX32[G11T0l;MT64PEDPxE1? NHXYcJQzPDBzNUOyOy=>
Hs578T MoG2R5l1d3SxeHnjJGF{e2G7 NXzp[VlrPDhiaB?= NHvhcIVFVVOR MXfHTV01Njh|IN88US=> NUnQcXhQOjRyMUWzNlc>
MDA-MB-231 NVXrW5Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG3PWlmPDhiaB?= M1zvdGlEPTB;MD6xOkDPxE1? MUOyOFA6PTBzNh?=
MCF7 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPzWmFsPDhiaB?= Ml;1S2k:OC52NTFOwG0> MXeyOFEyQTV3NR?=
MDA-MB-435 NEPvNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnxVFY1QCCq MXPHTV0xNjh6IN88US=> MWOyOFEyQTV3NR?=
AsPC1 NWrPTpZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvvdXk1OzBizszN MYq0PEBp NVXUZZZ6TE2VTx?= M2fwSGlEPTB;Mz62OkDPxE1? M2HKfFI1OTh3M{e4
Jurkat E6.1 NV7uPYhsU2mwYYPlJGF{e2G7 NUf2fVF4OiCq M2T0XGROW09? MlPZTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? M1SyfFI1OjZzOE[y
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HEL Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjXOmlUPDhiaB?= Ml3TSG1UVw>? M1f6cWlEPTB;MD60PUDPxE1? NHS4TYszPDZ7NEC1OS=>
HSC3 MknyR5l1d3SxeHnjJGF{e2G7 NV;pSYlNOTJiaB?= MW\EUXNQ M{frXmlEPTB;MD63NUDPxE1? M4LFWlI1PzZ4NU[w
HT-29 MVnDfZRwfG:6aXOgRZN{[Xl? M1jtPFEzKGh? M1ny[mROW09? MkDwTWM2OD1yLkeyJO69VQ>? NWPEUpI3OjR5Nk[1OlA>
KB M4DrcWN6fG:2b4jpZ{BCe3OjeR?= MWKxNkBp NV3oNW1WTE2VTx?= MYfJR|UxRTBwN{Wg{txO M3\RUFI1PzZ4NU[w
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MONE1 NILOT5JEgXSxdH;4bYMhSXO|YYm= MX6xNkBp NXP5NVBTTE2VTx?= M4C0SmlEPTB;MT6xPEDPxE1? M2nNelI1PzZ4NU[w
MKN45 NW[zR5RlS3m2b4TvfIlkKEG|c3H5 MVuxNkBp NYjGXoVsTE2VTx?= M2\LXmlEPTB;MT6yOUDPxE1? MYCyOFc3PjV4MB?=
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HEK293 NFjaS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[1TJY4OiCq NEPZfGdFVVOR MlvsS2k2OD1zMzFOwG0> M4TOR|I1QTByNUCw
Jurkat Mm\oR5l1d3SxeHnjJGF{e2G7 NELQUFgyODBizszN NFv5UGQ4OiCq NFj0O29IUTVyPUCuPUDPxE1? M1G0TlI1QTByN{Sz
GM15850 NVTGe3o3U2mwYYPlJGF{e2G7 MXyyMlUh|ryP NFfsdIk6PiCq M{LUWWROW09? NWm5eZJm\G:nczDuc5QhcW6qaXLpeEBJTEGFIHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGirc4TvcoUhUDNibInzbY5mKDF2IHHj[ZR6dGG2aX;uJI9nKE[[TjDn[Y5m MWSxOlkzOTN4Nx?=
GM15850 NHfiO|VMcW6jc3WgRZN{[Xl? M{HCN|IvPSEQvF2= NEHodIU6PiCq M1e5VGROW09? MmrC[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NVnFOpkyOTZ7MkGzOlc>
GM15850 MXTLbY5ie2ViQYPzZZk> NXmzVmpIOi53IN88US=> MlvjPVYhcA>? NHXIfmJFVVOR M3XJW4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UAyOiCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MoTpNVY6OjF|Nke=
GM15850 M{H5ZWtqdmG|ZTDBd5NigQ>? NF3wXYUzNjVizszN MlrXPVYhcA>? NX3JW5B[TE2VTx?= MXvkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NV\2U4dMOTZ7MkGzOlc>
GM15850 M2i4UGtqdmG|ZTDBd5NigQ>? NEHXZ4IzNjVizszN MXO5OkBp Mkf4SG1UVw>? M2DaR4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg1KGy7c3nu[UA5KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M2L4dVE3QTJzM{[3
GM15850 MnnwT4lv[XOnIFHzd4F6 MmrONk42KM7:TR?= NH71SHU6PiCq MV7EUXNQ NG\0eJFld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTZiYXPleJlt[XSrb36gc4YhTliQIHflcoU> NX;xVJBVOTZ7MkGzOlc>
GM15850 MWPGeY5kfGmxbjDBd5NigQ>? NGfZSmE2KM7:TR?= MkewNVIhcA>? M4f5Z2ROW09? Mm\XbIF{KG6xIHXm[oVkfCCxbjDGXG4hdVKQQTDlfJBz\XO|aX;u MmrSNVY6OjF|Nke=
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PANC1 M1XFPGZ2dmO2aX;uJGF{e2G7 NFXidJQyKM7:TR?= NWLsT5M6PDhiIHi= M2TWeoRw\XNibn;0JIlv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u NY\2N2MzOTd3OEi3OFQ>
Caco-2 NWrsW2dzTnWwY4Tpc44hSXO|YYm= NXvFdVlzPSEQvF2= MXuyOEBp NX64PWNvTE2VTx?= MoTj[I9meyCwb4SgbY5lfWOnIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v MYKyNFE1Ozh2MB?=
SCC4 M2PvdGZ2dmO2aX;uJGF{e2G7 NE\oZ28yKM7:TR?= NUTRVopjOTBibXnu NY\vTWFnTE2VTx?= NGniZVhp[XNibn:gZYdwdmm|dDDhZ5Rqfmm2eTDheEBXTFJiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKEO\UEK0JIdmdmViZYjwdoV{e2mxbh?= M4jZdVIxPDV{MkK1
A549 NVnCUohbTnWwY4Tpc44hSXO|YYm= Mn7OOUDPxE1? NGjtSYs{KGh? M1\He2ROW09? MV7kc4V{KG6xdDDpcoR2[2ViYYX0c5Bp[We7IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEyFM1nJ NV7HdXVDOjB6NUWyNFg>
HCT116 NVr2eIM4U2mwYYPlJGF{e2G7 NEjYSIIxNjNizszN NXToe4FmOzBiaB?= MojpSG1UVw>? MnLz[I9meyCwb4SgbY5pcWKrdDDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u MVKyNVA5ODZ2Nx?=
HepG2 MkXYSpVv[3Srb36gRZN{[Xl? Mk\WNVAh|ryP M1vGWFI1KGh? MWjEUXNQ Mn;W[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BpgXCncnHj[ZR6dGG2aX;uJI9nKHB3Mx?= NHTmT|kzOTV2OEW4Ni=>
GM11272 MUDGeY5kfGmxbjDBd5NigQ>? MVWwMlEh|ryP MkPtO|IhcA>? NHvHeGJFVVOR NUnkfFlm\G:nczDuc5QhemWjY4TpeoF1\SCPZVPwNkBufXSjboSg[ZhxemW|c3nvci=> NHv1WpUzOTh2MEexOi=>
MDA-MB-231 NIDlUJNMcW6jc3WgRZN{[Xl? MnPUNVAh|ryP M{PKU|UhdWmw M1G1bmROW09? MoW1[I9meyCwb4SgbY5pcWKrdDDISGFEOmF? NX7meZJ1OjN2OUO0OFk>
MDA-MB-231 NYLHc2dxU2mwYYPlJGF{e2G7 NYP0eHhqOSEQvF2= NGDzZWkzPCCq NHftPWpFVVOR M1f6XYRw\XNibn;0JIlvcGmkaYSgTGRCSzZiYYPz[ZN{\WRiYYOgZYNmfHmuYYTpc44hdGW4ZXzzJI9nKHS3YoXsbY4> NVvTVXhOOjN2OUO0OFk>
K562 M4r3cGtqdmG|ZTDBd5NigQ>? NGfHcJlld2W|IH7veEBqdmirYnn0JGhFSUN? NFTiRW8zOzV7MUGxNS=>
Jurkat MlvBR5l1d3SxeHnjJGF{e2G7 MlnwNlAh|ryP NWHUe5M{PzJiaB?= Ml;5SG1UVw>? Mlfuco8h[3m2b4TvfIlkcXS7IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;u Ml3KNlQ{ODR|NEi=
HCT116 NYHjc2lkSXCxcITvd4l{KEG|c3H5 NYHoTmZOOyEQvF2= NWPrXndTOjRiaB?= MV\EUXNQ NGfwOXRld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIIC1N{Bxem:2ZXnuJIxmfmWu NF;Ke48zPDd4NkW2NC=>
KASUMI-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq4TWM2OD17OT6xO{BvVQ>? NYTa[GFZW0GQR1XS
KARPAS-45 M2LUT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF5Mz64PUBvVQ>? MnjHV2FPT0WU
BHT-101 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ2ND6xPEBvVQ>? MVfTRW5ITVJ?
H9 NYfK[5hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPsUG1tUUN3ME2yOVUvODRibl2= NFjwcmVUSU6JRWK=
PA-1 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HoO2lEPTB;Mki2MlI3KG6P NHjvXHZUSU6JRWK=
NEC8 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJ6OT6zPEBvVQ>? NEPEcVZUSU6JRWK=
MHH-PREB-1 NXzQW2F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\pTWM2OD1{OUSuOVMhdk1? MUXTRW5ITVJ?
NB7 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTN2NT63OEBvVQ>? NFGxSWRUSU6JRWK=
A3-KAW M{XQfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPvNnRvUUN3ME20NFAvPTlibl2= MkG2V2FPT0WU
NB69 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrnTXhwUUN3ME20NVEvPzFibl2= M3[wSnNCVkeHUh?=
EoL-1-cell NVLzcoxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHhZVBKSzVyPUS1OFI2KG6P MoLEV2FPT0WU
CHP-212 NWnzVZNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXsTWM2OD12NUeuOVMhdk1? NGrWd4ZUSU6JRWK=
C2BBe1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr1NYw4UUN3ME20O|IvOTlibl2= M1\p[3NCVkeHUh?=
697 MlnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonUTWM2OD12N{OuOFEhdk1? NWDvTJR2W0GQR1XS
BCPAP NW\mfIFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHUTWM2OD13MEGuOFIhdk1? NGHFO25USU6JRWK=
L-363 NHnvT|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\iTWM2OD13MEOuNUBvVQ>? MY\TRW5ITVJ?
ES8 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHweIpSUUN3ME21NlMvPTNibl2= MkLQV2FPT0WU
BE-13 M3Lxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDEO|Q6UUN3ME21NlYvQTZibl2= MnO1V2FPT0WU
CTB-1 NFruVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnLOHZCUUN3ME21N|cvQTJibl2= MVHTRW5ITVJ?
HD-MY-Z MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnJTWM2OD13M{iuNVMhdk1? NXLT[mZ6W0GQR1XS
NKM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITYXolKSzVyPUW0OE4zPyCwTR?= M4eweXNCVkeHUh?=
NCI-H720 NF3TXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnlTWM2OD13NkCuNVghdk1? MomwV2FPT0WU
KY821 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTV4Mz6yOUBvVQ>? MVzTRW5ITVJ?
OVCAR-5 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTV5Nj6xNUBvVQ>? NF;tVHJUSU6JRWK=
CTV-1 Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTV6MT61OkBvVQ>? M1L4SnNCVkeHUh?=
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COLO-320-HSR Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny1TWM2OD1zLki4NVk4KM7:TR?= M4q0fHNCVkeHUh?=
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HT MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\BfXZFUUN3ME2xMlg5QTR5IN88US=> NGXVe4VUSU6JRWK=
LoVo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13PR2lEPTB;MT64PVgyKM7:TR?= MUHTRW5ITVJ?
CGTH-W-1 NXvseYk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf6TWM2OD1zLki5PVQ3KM7:TR?= MlHFV2FPT0WU
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EW-22 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmz[IZQUUN3ME2xMlkzQDh5IN88US=> MkXvV2FPT0WU
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HL-60 M1exbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnNNYVKSzVyPUGuPVM6ODJizszN Mn:xV2FPT0WU
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SW626 M13DXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTFwOUS4PVkh|ryP M3rxO3NCVkeHUh?=
HEC-1 NYLifWQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi5UnZJUUN3ME2xMlk2OzZizszN NEXWRWlUSU6JRWK=
LB2241-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnmTWM2OD1zLkm4NlMyKM7:TR?= M{T3OnNCVkeHUh?=
Ramos-2G6-4C10 MmS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTFwOUm0PVMh|ryP NXnRO4N4W0GQR1XS
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NCI-H446 M2\LcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn70TWM2OD1{LkC0OVk6KM7:TR?= NYnQfoxvW0GQR1XS
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HOS MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\weXdQUUN3ME2yMlA4PjV|IN88US=> MnK0V2FPT0WU
K5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnsfJdOUUN3ME2yMlA4QDFzIN88US=> MoXJV2FPT0WU
HLE MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zNRmlEPTB;Mj6wPFUzQSEQvF2= MVrTRW5ITVJ?
HSC-2 Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ThUWlEPTB;Mj6xNlg6QCEQvF2= NHrLWXpUSU6JRWK=
LCLC-97TM1 NF61XmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnPd3BKSzVyPUKuNVQ2QDNizszN M1naPHNCVkeHUh?=
DMS-273 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXNeW5pUUN3ME2yMlE1QDN5IN88US=> NHrhSYJUSU6JRWK=
TE-8 M4Pjfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfQTWM2OD1{LkG1O|Y2KM7:TR?= MV;TRW5ITVJ?
DSH1 NWnTeFhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrWN4xpUUN3ME2yMlE3Ozl6IN88US=> MoG0V2FPT0WU
CAL-51 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1uwN2lEPTB;Mj6xOlY6QSEQvF2= MVvTRW5ITVJ?
IST-SL1 M1HPSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PReGlEPTB;Mj6xOlg1PCEQvF2= MVzTRW5ITVJ?
GCT MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1roWWlEPTB;Mj6xO|c4KM7:TR?= NYHrd5hwW0GQR1XS
SW948 NFTOcnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\qTWM2OD1{LkG4OFU3KM7:TR?= Mo[wV2FPT0WU
NOMO-1 M{DGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHQW5RKSzVyPUKuNVk{OTdizszN M4ezb3NCVkeHUh?=
C8166 NV3qU4NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwMkGzN|Qh|ryP MoHDV2FPT0WU
OC-314 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe0UYFTUUN3ME2yMlI{OjV7IN88US=> NHj6fmFUSU6JRWK=
CAL-39 MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jve2lEPTB;Mj6yN|YzPiEQvF2= M33RdXNCVkeHUh?=
MDA-MB-453 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fheGlEPTB;Mj6yOFI4PSEQvF2= NHv3bYZUSU6JRWK=
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NCI-H1666 M4Owbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHp[oRKSzVyPUKuNlgyOTFizszN NYO0NnFQW0GQR1XS
PSN1 M2PMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPSbFVnUUN3ME2yMlI5QTF|IN88US=> M2HqfHNCVkeHUh?=
GI-1 M1PKXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS4TWM2OD1{LkOwOVQ{KM7:TR?= NXz2WmplW0GQR1XS
HuH-7 NVezUY1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP4TWM2OD1{LkOwOlM4KM7:TR?= NVrnNYw6W0GQR1XS
JAR M4jQcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LiPWlEPTB;Mj6zNVk5PyEQvF2= MkHGV2FPT0WU
5637 NX7DfmR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXXTWM2OD1{LkOyNVI6KM7:TR?= M1q1XHNCVkeHUh?=
GB-1 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJwM{KzN|Uh|ryP M2CxU3NCVkeHUh?=
KP-N-YS Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHhTWM2OD1{LkOyOlE2KM7:TR?= MULTRW5ITVJ?
OAW-42 NIHRRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJwM{O0NVYh|ryP MVfTRW5ITVJ?
8-MG-BA MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\Kd2lEPTB;Mj6zN|kxPiEQvF2= NWjVblJGW0GQR1XS
RH-18 M4SxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJwM{WwNlIh|ryP NEDX[|JUSU6JRWK=
NCI-H1155 MmfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[0TGlEPTB;Mj6zOlczPSEQvF2= M3n5PXNCVkeHUh?=
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NCI-H1437 M{ftN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\zdlhKSzVyPUKuOFE5PzNizszN MkDUV2FPT0WU
SN12C MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJwNEOyNVQh|ryP MmX6V2FPT0WU
HSC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwNES1NFkh|ryP MVHTRW5ITVJ?
GAMG M{TTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqy[HB[UUN3ME2yMlQ1PTZzIN88US=> NFHQbmVUSU6JRWK=
HT-1080 M2LQeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnBW4tqUUN3ME2yMlQ1QDZ2IN88US=> NYi4PVRpW0GQR1XS
A549 M37OOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLVcopKSzVyPUKuOFQ5QTNizszN NWHnVFk{W0GQR1XS
KNS-62 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jzUGlEPTB;Mj60OVA3OSEQvF2= NVHSdohiW0GQR1XS
YKG-1 NUX5TG5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwNEW0N|ch|ryP MWrTRW5ITVJ?
LU-134-A NGjQOGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\DVWlEPTB;Mj60O|AxQCEQvF2= M{PRV3NCVkeHUh?=
FADU NImyVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjaNGpKSzVyPUKuOFcyPjJizszN NEDDfGVUSU6JRWK=
TGBC11TKB MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzCTWM2OD1{LkS3NVc4KM7:TR?= MX\TRW5ITVJ?
HT-3 NWPrVHh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEC0R2dKSzVyPUKuOFk2OzVizszN MYDTRW5ITVJ?
NCI-H2170 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[1UWd5UUN3ME2yMlUxPTR7IN88US=> NFywWJJUSU6JRWK=
Mo-T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYqyUVV1UUN3ME2yMlUxQTJ5IN88US=> NIHSTWZUSU6JRWK=
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KU-19-19 M4TEcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf6TWM2OD1{LkWzOVE{KM7:TR?= MXLTRW5ITVJ?
NCI-H1048 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjhfGpKSzVyPUKuOVUxOjVizszN NVXL[I5xW0GQR1XS
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MKN28 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjvfFNYUUN3ME2yMlU6ODN5IN88US=> MXvTRW5ITVJ?
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ABC-1 NY\5UY5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPHTWM2OD1{Lk[wOFYh|ryP MXnTRW5ITVJ?
NCI-H2126 NHrzSXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzqVldpUUN3ME2yMlYxQTh2IN88US=> MUfTRW5ITVJ?
DoTc2-4510 M17GSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJwNkKxPFUh|ryP NUHFdYlVW0GQR1XS
SCC-4 NYHJbIJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLrXodKSzVyPUKuOlMxOTJizszN MlH1V2FPT0WU
NCI-H661 NWThfFdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvXOVNKSzVyPUKuOlQxQDVizszN MVXTRW5ITVJ?
RPMI-2650 M{\WWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\0RlhKSzVyPUKuOlQyPDNizszN Ml;PV2FPT0WU
NCI-H510A NYrIc3Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jQNmlEPTB;Mj62OFQzPiEQvF2= NIHuNFRUSU6JRWK=
BPH-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPLTWM2OD1{Lk[1PFUh|ryP MonGV2FPT0WU
M14 NY\tO2x[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPIclVKSzVyPUKuOlY6QTNizszN MVPTRW5ITVJ?
G-402 MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\4TmlEPTB;Mj63NFQ2OSEQvF2= M4\kdHNCVkeHUh?=
AsPC-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHBTWM2OD1{LkexNVch|ryP NWrwVmNRW0GQR1XS
NB12 NH;SO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HHT2lEPTB;Mj63NVcyKM7:TR?= MX\TRW5ITVJ?
SK-HEP-1 NUPveXhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO3TWM2OD1{Lke0N|kyKM7:TR?= NV7x[HBtW0GQR1XS
U-266 NVjVdGR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TDbGlEPTB;Mj63O|EzOSEQvF2= NUHYfYttW0GQR1XS
AM-38 NF7UbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwN{ezOVUh|ryP MUPTRW5ITVJ?
PC-14 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zofmlEPTB;Mj64NFUyKM7:TR?= M2n5XHNCVkeHUh?=
EGI-1 NG\F[YFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfLR5RjUUN3ME2yMlgyPzR|IN88US=> MmDDV2FPT0WU
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BFTC-905 NHezT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TmUWlEPTB;Mj64OVUzOyEQvF2= NEfrdoJUSU6JRWK=
CaR-1 NG[0XYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnDO|VKSzVyPUKuPFYh|ryP NITUT|FUSU6JRWK=
NCI-H292 NI\HS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KwfWlEPTB;Mj64OlU6PiEQvF2= MknNV2FPT0WU
8305C MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr0bFZpUUN3ME2yMlg3PjR3IN88US=> NYLMeHQ6W0GQR1XS
SNU-449 MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXwfVRKSzVyPUKuPFkyQDJizszN MmTiV2FPT0WU
LCLC-103H M4[5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXm0TGlzUUN3ME2yMlkxPDN6IN88US=> NELZd3JUSU6JRWK=
SW1573 NGrRcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq5TWM2OD1{Lkm2NFgzKM7:TR?= NVHZNXg{W0GQR1XS
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NCI-H1355 M1fCfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr4VZBKSzVyPUOuNFA4QTZizszN NHznWZdUSU6JRWK=
RMG-I NEnjc2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLDTWM2OD1|LkCyOVkzKM7:TR?= NYLibXN7W0GQR1XS
BB65-RCC NYDoZokxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rTe2lEPTB;Mz6wN|MyPCEQvF2= NHvRT21USU6JRWK=
PC-3 NULpe41vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwMEO4O|Qh|ryP MoLYV2FPT0WU
SF268 NU\PSVFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TVWmlEPTB;Mz6wOFUzOyEQvF2= M{\tSnNCVkeHUh?=
NCI-H810 MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTNwMES4NlMh|ryP NFHad4xUSU6JRWK=
MEG-01 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfQdolMUUN3ME2zMlA3OTZ2IN88US=> MUDTRW5ITVJ?
SW13 MnS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TBTmlEPTB;Mz6wO|g1PyEQvF2= M{\ncnNCVkeHUh?=
RH-1 NVP1XZRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwMUCyO|gh|ryP MnjzV2FPT0WU
GT3TKB MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwMUGyPFMh|ryP MmrYV2FPT0WU
TK10 NXu5eFl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17JTmlEPTB;Mz6xN|czPCEQvF2= NUHq[25OW0GQR1XS
T-24 NFzKOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlmwTWM2OD1|LkG1NFch|ryP M1Lkb3NCVkeHUh?=
A498 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPLVVZXUUN3ME2zMlIxQDdzIN88US=> M3nNVnNCVkeHUh?=
GR-ST NGnsUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnEbnZ4UUN3ME2zMlIzOTN7IN88US=> NGfrSVVUSU6JRWK=
LB2518-MEL MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTNwMkKzPVgh|ryP NGfrbo1USU6JRWK=
T47D M1LuWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTNwMkO2Nlch|ryP NUPOToh6W0GQR1XS
NCI-H1651 NYXtWJB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fze2lEPTB;Mz6yOFY1PCEQvF2= MoTQV2FPT0WU
EC-GI-10 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSzTWM2OD1|LkK2NVU{KM7:TR?= MlzwV2FPT0WU
HT-29 NGPLb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK4e5BVUUN3ME2zMlI3PjF2IN88US=> MUDTRW5ITVJ?
GI-ME-N MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3NTWM2OD1|LkK5OVEyKM7:TR?= MnG4V2FPT0WU
SW756 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;TO4lmUUN3ME2zMlI6PjJ7IN88US=> NUnaTZJPW0GQR1XS
RKO NHLkc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHE[oREUUN3ME2zMlMxPzV5IN88US=> MULTRW5ITVJ?
NCI-H1563 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTNwM{OwNVgh|ryP MX7TRW5ITVJ?
DJM-1 Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTNwM{e2O|Qh|ryP NF3kcnNUSU6JRWK=
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NCI-H82 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ4LkSyPFgh|ryP Ml3kV2FPT0WU
COLO-678 NEfKU3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXyTWM2OD1{Nz60PVE6KM7:TR?= NEDDcFdUSU6JRWK=
KURAMOCHI NInKbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWntRlIyUUN3ME2yPE4yOjZizszN NHW3eIpUSU6JRWK=
NCI-H1650 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXKTWM2OD1|MD6xPVI1KM7:TR?= M3LUUHNCVkeHUh?=
HCC1954 NITIRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHYcYozUUN3ME2zNU4{PjZ4IN88US=> M1;WU3NCVkeHUh?=
GAK NEDkOFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTSU3NQUUN3ME2zNk4zPjF4IN88US=> NXXZ[nU6W0GQR1XS
YAPC M3\acWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fpW2lEPTB;M{OuO|Y1QCEQvF2= M2jCZnNCVkeHUh?=
NCI-H2228 M2LTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTN2LkO2NFUh|ryP NFG3em5USU6JRWK=
VMRC-RCZ Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTN4LkOwNlIh|ryP NHm2b4JUSU6JRWK=
NMC-G1 M4ryeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrnNmhKSzVyPUO3MlA2OjlizszN Mm\kV2FPT0WU
D-336MG NF[xTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3tTYVKSzVyPUSxMlg1PDJizszN NIfPeJZUSU6JRWK=
UACC-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTR{LkW1NFUh|ryP NHnQb4dUSU6JRWK=
C-33-A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTR3LkOyOVYh|ryP M3q2PHNCVkeHUh?=
HCC1937 NHH4d2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTR5LkG5OVgh|ryP NUXTNYN[W0GQR1XS
HDLM-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTR5LkKyPFch|ryP MkHuV2FPT0WU
NCI-H727 NVyw[YF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXnZnlSUUN3ME20O{4zPDVzIN88US=> M1fTZnNCVkeHUh?=
NY NH65TGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn4b4ZKSzVyPUS5MlM6ODhizszN MnvoV2FPT0WU
NCI-H2291 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DB[mlEPTB;NEmuPFMxOSEQvF2= MWXTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Suspended Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID