Vorinostat (SAHA)

For research use only. Not for use in humans.

Catalog No.S1047 Synonyms: MK0683

267 publications

Vorinostat (SAHA) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Selleck's Vorinostat (SAHA) has been cited by 267 publications

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Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 MULLbY5ie2ViQYPzZZk> MYSxJIg> MnfNSG1UVw>? MVzhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? MVGxNVk3ODR6OR?=
Friend leukemic cell NVzXTYx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL0N4p2PTBizszN M2HQSFczKGh? NWLVcVBETE2VTx?= NX:0VG9sUUN3ME2wMlk6KM7:TR?= NFXt[msyOjFyOUmxNy=>
K562 NYLRSlJCU2mwYYPlJGF{e2G7 NF;RUmE3KGh? NGTtPGFFVVOR M1;3emlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> NV\WcXIyOTJ2MUmzPFA>
HT1080 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUG3NkBp MXjEUXNQ MYHJR|UxRTJwNDFOwG0> NUDzXJpJOTJ{N{CxO|U>
H1299 NGThV3pMcW6jc3WgRZN{[Xl? NVK0S4VGOjBibXnu M3naUmROW09? Mnz6TY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= M1PTNlE1PTJzNEKy
H1299 MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LoVFczKGh? NEnXUVZFVVOR MkTiTWM2OD15LkK0JO69VQ>? MXWxOFUzOTR{Mh?=
HeLa M2SzTWtqdmG|ZTDBd5NigQ>? NV;QWXRnOzBibXnu M{W4NWlvcGmkaYTvdpkh[2:wY3XueJJifGmxbjDh[4FqdnO2IHjpd5RwdmViZHXhZ4V1gWyjc3Wge4l1cCCLQ{WwJI9nKDBwMkig{txO NUO4VHBEOTV4MEO5OFk>
LOX-IMVI NYf2fmVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVK0PEBp MVLJR|UxRTFwMzFOwG0> MWqxOVcyPTR5MB?=
NCI-H226 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVS0PEBp M3rsd2lEPTB;Mj62JO69VQ>? M3P3S|E2PzF3NEew
RXF-631L NW\jU4xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7DOFghcA>? MWTJR|UxRTJizszN M4PzRVE2PzF3NEew
SNB-78 MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjyOFghcA>? M4jhN2lEPTB;MU[g{txO NFTU[FgyPTdzNUS3NC=>
St-4 MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzrbm1MPDhiaB?= M3zjfWlEPTB;NT6yJO69VQ>? NWfuNmsyOTV5MUW0O|A>
ARP1 NILEc4JHfW6ldHnvckBCe3OjeR?= NV7abIl4OiEQvF2= M2XhVVYhcA>? NWW5V5JVUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NHrwSIgyPDd|NEiwOi=>
CEM M1XmdWtqdmG|ZTDBd5NigQ>? M2rPXVEhcA>? NYjRc3pQTE2VTx?= MoH5TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? MUOxOlQzODB4NB?=
HCT15 NFzNUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX20PEBp M37YdWdKPTB;MD64NkDPxE1? NWC2T2VqOTZ5MkOyNlc>
NCI-H23 NVS0b29ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDrbnY1QCCq M4fPZWdKPTB;MD65NkDPxE1? MlyyNVY4OjN{Mke=
GM15850 NFvGPYJMcW6jc3WgRZN{[Xl? NWDXZYlHOi53IN88US=> MVu5OkBp Mnu0SG1UVw>? MnjiTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MkjUNVY6OjF|Nke=
GM15850 MlfFT4lv[XOnIFHzd4F6 NI\mXVAzNjVizszN M2PUU|k3KGh? NGHGTY9FVVOR NInCSlZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NETqTJYyPjl{MUO2Oy=>
GM15850 M3vFXmtqdmG|ZTDBd5NigQ>? Mm\KNk42KM7:TR?= MlSxPVYhcA>? MYXEUXNQ M2LabWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NYq2UXpqOTZ7MkGzOlc>
GM15850 NELt[5RMcW6jc3WgRZN{[Xl? M{TSVVIvPSEQvF2= NEDUSHc6PiCq MWXEUXNQ NFey[JVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NWD2d|BrOTZ7MkGzOlc>
GM15850 NGPhTXdMcW6jc3WgRZN{[Xl? M3\TO|IvPSEQvF2= NGrHcmo6PiCq M3LydGROW09? MXzJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViODDhZ4V1gWyjdHnvckBw\iCIWF6g[4Vv\Q>? NWnTWZU{OTZ7MkGzOlc>
GM15850 NUS3S|hLU2mwYYPlJGF{e2G7 MWOyMlUh|ryP MWq5OkBp MXLEUXNQ NHHyXZZKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVYh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M2ntTlE3QTJzM{[3
U937 NUnNPFQ5TnWwY4Tpc44hSXO|YYm= NInhUHQ2KM7:TR?= NGfvTGUzPCCq MVPEUXNQ NEfYRotE\WyuIHP5Z4xmKGG{cnXzeEBjgSCjY3P1cZVt[XSrb36gZZQhWy:JMj;NJJBp[XOn MmDQNVcxODR5MUi=
H661 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qyPFQ5KGh? NWLUUGlLUUN3ME2xJO69VQ>? MlLKNVcyPTdyMEm=
U937 MWrGeY5kfGmxbjDBd5NigQ>? NHS1Sm02KM7:TR?= MUKyOEBp NHf3OYtFVVOR MUnJcoNz\WG|ZTDpckBpcXO2b37lJGg{KGGlZYT5cIF1cW:w NIPZPHEyPzR2N{e1NC=>
U937 NHPFUIRHfW6ldHnvckBCe3OjeR?= MXOxJO69VQ>? MWCyOEBp MlfQSG1UVw>? MWHF[oZm[3Rib36gZYxxcGFidIXieYxqdiCjY3X0fYxifGmxbh?= NEHJbpkyPzR2N{e1NC=>
RAW264.7 NV:wZZZVTnWwY4Tpc44hSXO|YYm= M4rUT|ExKM7:TR?= NFrnU4EzPGh? NFXW[mx4[XSnch?= MV3Jcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP Mm\vNVc1Pzd3MUi=
RAW264.7 MULGeY5kfGmxbjDBd5NigQ>? NFTsO5QyOCEQvF2= M2LTWlI1cA>? NFvvNG94[XSnch?= NVHlOGt4UW6qaXLpeIlwdiCxZjDMVHMue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJJdqfGhiSVO1NEBw\iBzLki4JO69VQ>? NIHKN4YyPzR5N{WxPC=>
SC9 NYnITnUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfhVpE1QCCq MlPITWM2OD1yLk[wOkDPxE1? NU\zRnB5OTd3MEeyNVk>
ST14A MUHGeY5kfGmxbjDBd5NigQ>? M{\OblUhdk1? NVLjZ2o4PzJiaB?= NI[3U3BKdmO{ZXHz[UBqdiCURWPUM25TW0ZibWLORUBmgHC{ZYPzbY9v NVy4Z2NrOTd3NkW5PVM>
ST14A M1i0[mZ2dmO2aX;uJGF{e2G7 MWS1JI5O MXi3NkBp M1T6OGlv[3KnYYPlJIlvKEV{RkGgcXJPSSCneIDy[ZN{cW:w NFLxXWMyPzV4NUm5Ny=>
PANC1 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rTflEh|ryP NWG3NmNvUUN3ME2wMlQ2KM7:TR?= MmXyNVc2QDh5NES=
PANC1 M2m1[WZ2dmO2aX;uJGF{e2G7 M1zhV|Eh|ryP MWCyOEBp MlzQTY5kemWjc3WgbY4heDJzV1HGNU9EUVBzIHflcoUh\XiycnXzd4lwdg>? Mn\PNVc2QDh5NES=
PANC1 NHfmZ4tHfW6ldHnvckBCe3OjeR?= MnzaNUDPxE1? M2XleVI1KGh? NIPDZ|dKdmO{ZXHz[UBqdiCyMkfrbZAyKGenbnWg[ZhxemW|c3nvci=> NEjwXJkyPzV6OEe0OC=>
PT45 M{jpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zwfmlEPTB;NDFOwG0> NILWWokyPzV6OEe0OC=>
ACHN Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nGWlIyKGh? M2fadGdKPTB;MD62OUDPxE1? NV\3WoRTOTd4NkK2NFY>
PC3 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYriTm5MOjFiaB?= NIn4OJlIUTVyPUCuO|Eh|ryP MYexO|Y3OjZyNh?=
A431 MWLDfZRwfG:6aXOgRZN{[Xl? NH\yXWg4OiCq NFvKW2RKSzVyPUSuNkDPxE1? NFfqcZoyPzZ7MUe2Ny=>
Cal27 NEjOWldEgXSxdH;4bYMhSXO|YYm= MlTqO|IhcA>? NETpV|ZKSzVyPUOuNkDPxE1? NXP5e3dpOTd4OUG3OlM>
CCRF-CEM MXPDfZRwfG:6aXOgRZN{[Xl? MWC3NkBp MXXJR|UxRTBwODFOwG0> M1zZR|E4PjlzN{[z
EOL1 NU\5SmpNS3m2b4TvfIlkKEG|c3H5 M4nJdlczKGh? NGrIcopKSzVyPUGg{txO MX[xO|Y6OTd4Mx?=
Hec-1-A MoTTR5l1d3SxeHnjJGF{e2G7 MYe3NkBp NXHnOndvUUN3ME2xJO69VQ>? NYHZfHBvOTd4OUG3OlM>
HeLa NGT4UYdMcW6jc3WgRZN{[Xl? NVm5c5hiOTBizszN Mm\qN|AhdWmw NGrQU25FVVOR M{TSfWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgTGRCSzFid3n0bEBKSzVyIH;mJFAvODJizszN NXKx[m5LOTd4OUG3OlM>
RKOp21 NH3WRVBEgXSxdH;4bYMhSXO|YYm= NGPr[os4OiCq Ml;1TWM2OD1zLke2JO69VQ>? NXTUfYI3OTd4OUG3OlM>
Saos2 M1WxZmN6fG:2b4jpZ{BCe3OjeR?= MUS3NkBp MVTJR|UxRTJwMzFOwG0> M4LWV|E4PjlzN{[z
SK-OV-3 MWTDfZRwfG:6aXOgRZN{[Xl? MljPO|IhcA>? MUXJR|UxRTJwMjFOwG0> NWHEVGZ7OTd4OUG3OlM>
U87MG M1Sx[GN6fG:2b4jpZ{BCe3OjeR?= M4\nNFczKGh? NELtUZVKSzVyPUGxJO69VQ>? MV[xO|Y6OTd4Mx?=
NUGC3 M2jYN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXYfYFbPSEQvF2= NXHTfWVlOjRiaB?= NHzTc5RIUTVyPUKuO|kh|ryP Mn3iNVc6ODR6NEO=
CCD1059SK M376NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnEWmQ6UUN3ME20N{42KM7:TR?= NEm1VnAyQDJ2N{W1OC=>
HepG2 NFLufXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7oWZVUUUN3ME2wMlAxODZizszN MlTCNVgzPDd3NUS=
HT1080 MmLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\pbWlEPTB;MD6wNFI1KM7:TR?= NY[1U4ZTOTh{NEe1OVQ>
SKBR3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDTTWM2OD1yLkig{txO MnHrNVgzPDd3NUS=
SNB78 M3viTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;FR|UxRTF4IN88US=> NX3NO4ZyOTh{NEe1OVQ>
SQ20B M3vOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTNizszN NVvyeJpuOTh{NEe1OVQ>
St4 Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXQd5JGSzVyPUWuNkDPxE1? M3r1ZlE5OjR5NUW0
MCF7 MV;GeY5kfGmxbjDBd5NigQ>? M{\xPVExKM7:TR?= MkfEPEBp NFvpc5RFVVOR NF7hWnBKdmS3Y4Tpc44hd2ZidIXieYxqdiCqeYDldoFk\XS7bHH0bY9v M2jVUVE5OjZ7MkK2
HEK293 MnP1T4lv[XOnIFHzd4F6 MoXlNUBp M{DBdmROW09? MnzSTY5pcWKrdHnvckBw\iCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6wN{DPxE1? MY[xPFMxQDV4Mx?=
HEK293 NFTiTnBMcW6jc3WgRZN{[Xl? M{\NVFEhcA>? MnHUSG1UVw>? NU\lSJEzUW6qaXLpeIlwdiCxZjDISGFEOyC5aYToJGlEPTBib3[gNE4xPTdizszN M{KxflE5OzB6NU[z
G401 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVq3NkBp M4jWSGROW09? Mn3vTWM2OD1zIN88US=> MoTTNVg{PzB|N{O=
HeLa MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e2T|czKGh? M{\wNWROW09? M{\TeGlEPTB;MD60OkDPxE1? M33aSlE5OzdyM{ez
Human renal epithelial cell M1r0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVi3NkBp NFXHRpRFVVOR Mn\RTWM2OD1zNDFOwG0> NUDGfpR[OTh|N{CzO|M>
U937 NUL4TWxPTnWwY4Tpc44hSXO|YYm= MUS1JO69VQ>? MWGyOEBp MnHmTY5lfWO2aX;uJI9nKGirc4TvcoUhUDRiaInw[ZJi[2W2eXzheIlwdg>? NX72WGN6OTh|OEGyN|g>
U937 NEXIc|dHfW6ldHnvckBCe3OjeR?= MUW1JO69VQ>? NG[1dpQzPCCq MWnJcoR2[3Srb36gc4Yh[WyyaHGgeJVjfWyrbjDofZBmemGlZYT5cIF1cW:w MWOxPFM5OTJ|OB?=
U937 NHHTR2NHfW6ldHnvckBCe3OjeR?= Mn;FOUDPxE1? NEC0dIozPCCq NFPUOm1KdmS3Y4Tpc44hd2ZicEKxJIV5eHKnc4Ppc44> NV;vTJN{OTh|OEGyN|g>
U937 NUjmTWhETnWwY4Tpc44hSXO|YYm= MmHCOUDPxE1? NX7nW|IxOjRiaB?= M3mwdWlv\HWldHnvckBw\iCjcH;weI9{cXN? M4HWZ|E5OzhzMkO4
U937 NGTXfHZHfW6ldHnvckBCe3OjeR?= MoTvOUDPxE1? NGXRV|YzPCCq MXnJcoR2[3Srb36gc4Yh\3KjboXsc4N6fGmlIHTp[oZmemWwdHnheIlwdg>? NXS5fJR3OTh|OEGyN|g>
U937 M1Kz[2tqdmG|ZTDBd5NigQ>? M4ridlUh|ryP M1LE[FI1KGh? NVu1cnRnUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDNS=> MlnNNVg{QDF{M{i=
U937 NYPkeppMU2mwYYPlJGF{e2G7 MVG1JO69VQ>? MYiyOEBp MkjRTY5pcWKrdHnvckBw\iCqdX3hckBJTEGFNB?= MmjZNVg{QDF{M{i=
HEK-TE NEG5W|RHfW6ldHnvckBCe3OjeR?= NF\nWlY2KM7:TR?= NVLuOXZ7Pmh? MYXEUXNQ MoHsTY5kemWjc3WgbY4hcGm|dH;u[UBJOyCjY3X0fYxifGmxbh?= NYTHcFBPOTh2M{SxOFQ>
HPDE6c7 MVLDfZRwfG:6aXOgRZN{[Xl? NYq3bXBvPTBizszN NVGyWoF5PzJiaB?= Mm\PSG1UVw>? MXTJR|UxRTFwMzFOwG0> NFmwXWwyQDR7NES2Ny=>
Human microvascular epithelial cell NFLlUnFEgXSxdH;4bYMhSXO|YYm= NIHpW5U2OCEQvF2= M3LHOVczKGh? NFz4e5VFVVOR M13oXGlEPTB;MT6zJO69VQ>? MoPENVg1QTR2NkO=
Hup T3 M3HmfmN6fG:2b4jpZ{BCe3OjeR?= M1\YeVUxKM7:TR?= MXe3Nog> MX7EUXNQ MUnJR|UxRTBwODFOwG0> MofZNVg1QTR2NkO=
Mia Paca2 M334NWN6fG:2b4jpZ{BCe3OjeR?= MnKxOVAh|ryP NWjnN2g5PzKq NY[5eXJ3TE2VTx?= NF\ic45KSzVyPUGuNUDPxE1? MX:xPFQ6PDR4Mx?=
Panc 04.03 NUHLWml1S3m2b4TvfIlkKEG|c3H5 MXK1NEDPxE1? NEHsTIU4Omh? MVnEUXNQ MWfJR|UxRTFwMjFOwG0> NYG3WnhHOTh2OUS0OlM>
SU 86.86 NX3BfXhiS3m2b4TvfIlkKEG|c3H5 NWf6UG1RPTBizszN M{[w[VczcA>? NYWxUGhYTE2VTx?= MV3JR|UxRTFwMzFOwG0> MmXxNVg1QTR2NkO=
HEK293 MYTLbY5ie2ViQYPzZZk> M{LUdFMhcA>? MWXJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFjERWM3KGW6cILld5Nqd25id3n0bEBKSzVyIH;mJFAvODF7IN88US=> MorCNVg2PTh4Nkm=
HeLa M2PjPWtqdmG|ZTDBd5NigQ>? NFnLcmQzKGh? NVjp[VZRUW6qaXLpeIlwdiCxZjDueYNt\WG{IFjERWMhf2m2aDDJR|UxKG:oIECuNFg{KM7:TR?= NHOwfo0yQDV3OE[2PS=>
RAW264.7 NFy1[mxHfW6ldHnvckBCe3OjeR?= MWKyJO69VQ>? NHvHNoM{NjViaB?= MorSSG1UVw>? MV\BcpRqdWGuYYLpZYwh[WO2aY\peJkh[WejaX7zeEBRdGG|bX;kbZVuKG[jbHPpdIFzfW1iaX7m[YN1\WRid3n0bEBKSzVyIH;mJFAvOTFizszN M{nOUlE5PjR2OU[5
NB4 NGjV[3Q1QGh? M{TPdGROW09? NXjuWFhWUUN3ME2wMlYh|ryP NIq3Z|QyQDd{M{O0PS=>
HEK293 M4nHbGZ2dmO2aX;uJGF{e2G7 Mn\QNVAh|ryP NGjieXEzPCCq NWHHb|BFTE2VTx?= MlnvRYN1cX[jdHnvckBw\iCvb4Xz[UBYdnR|YTDzbYdv[Wyrbneg[ZhxemW|c3Xk NUnsZXZMOTlyMkK2O|U>
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HeLa MYDDfZRwfG:6aXOgRZN{[Xl? M1rEN|czKGh? NYTFbJA5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyCxdnXy[ZhxemW|c3nu[{BJTEGFIIfpeIghUUN3MDDv[kAyNjVizszN NVS4bHJbOjFyOEC2Nlk>
Sf21 NF65NGNMcW6jc3WgRZN{[Xl? NFOyZ20{KGh? M4LoZWlvcGmkaYTpc44hd2ZiRnzh[{B1[WepZXSgbJVu[W5icnXjc41jcW6jboSgTGRCSzhiZYjwdoV{e2WmIIfpeIghUUN3MDDv[kAyNjJizszN NHTXTlAzOTB6ME[yPS=>
SKBR3 M4njdWN6fG:2b4jpZ{BCe3OjeR?= MYC3NkBp MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP NG\MTpozOTB6ME[yPS=>
SKOV3 MXvDfZRwfG:6aXOgRZN{[Xl? MmDBO|IhcA>? NUKwU5FES3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NHfMNmgzOTB6ME[yPS=>
COR-L23 M1;5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e0bFExKM7:TR?= NWrxOoV5PzJiaB?= NEDqXWlFVVOR MYPHTVUxRTFwMTFOwG0> MVWyNVA5ODZ2Nx?=
DU145 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfK[nVDOTBizszN MnLUO|IhcA>? MlXvSG1UVw>? NETWS|RIUTVyPUGuNFUh|ryP MmftNlExQDB4NEe=
LoVo NF3oZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUGxNEDPxE1? NV3YNGxsPzJiaB?= MnHwSG1UVw>? NXTEUopyT0l3ME2xMlch|ryP NYHxWVBiOjFyOEC2OFc>
MCR5-SV2 NWjwWodIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYWxNEDPxE1? NWrD[YRIPzJiaB?= M4DkPWROW09? MmnxS2k2OD1{LkGg{txO NEjFW|YzOTB6ME[0Oy=>
HCT116 MUnLbY5ie2ViQYPzZZk> MX2zNEDPxE1? NGDDboU{OCCq MWrEUXNQ M3rjO2lvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= NF[xbI4zOTB6ME[0Oy=>
HCT116 M{LLcGtqdmG|ZTDBd5NigQ>? NX3UNlZKOzBizszN MkjJN|AhcA>? NFrnWpBFVVOR NV\kWZJTUW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u MWWyNVA5ODZ2Nx?=
U937 MVfLbY5ie2ViQYPzZZk> NGHqc5I2KM7:TR?= M2SwVlI1KGh? M3X1SmROW09? MmrXTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? MWeyNVI6OjR7Mh?=
U937 M2T5V2tqdmG|ZTDBd5NigQ>? MoTaOUDPxE1? MWiyOEBp NEPZZ5FFVVOR M{Tr[WlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= M3nXbVIyOjl{NEmy
U937 NIrGd3BMcW6jc3WgRZN{[Xl? NFXhOpI2KM7:TR?= MYOyOEBp NVu4eGxwTE2VTx?= MYnJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gdIFvNWGlZYT5cIF1\WRiaHnzeI9v\SCKNDDs[ZZmdA>? M132flIyOjl{NEmy
U937 NYLhemZWU2mwYYPlJGF{e2G7 NF;3dHY2KM7:TR?= NXW3TItrOTVibXnu MknGSG1UVw>? MkXOTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> NXjkcm1IOjF{OUK0PVI>
A2780 NHWxepNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWS5OkBp NICxTmlFVVOR M3jzfWlEPTB;MT62NkDPxE1? M1G2O|IyPjN2NEOw
COLO205 MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XHd|k3KGh? NHvXSopFVVOR MULJR|UxRTJwMUKg{txO MnHwNlE3OzR2M{C=
Hep3B NHzBSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDaOFghcA>? M1KyZWROW09? NE\hN5JIUTVyPUGuNlEh|ryP M1TqTFIyPzF{MUS2
GM11272 MmrESpVv[3Srb36gRZN{[Xl? NVvXZ21yOTByIH7N NULZNph4PzJiaB?= NVjNeGZbTE2VTx?= NIfwPI5T\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O M3zufVIyQDRyN{G2
CFBE41o MYjLbY5ie2ViQYPzZZk> NIjTTW42KM7:TR?= MkK4SG1UVw>? MUjEc5dvKHKnZ4XsZZRqd25ib3[gTGRCSzdiYYSgNE4zKHSxIEWgeW0> MXeyNVk5PDl3OB?=
CFBE41o MVPGeY5kfGmxbjDBd5NigQ>? NF7zNnEyKM7:TR?= MmK3NlQhcA>? MVXEUXNQ MmH3VoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| MYmyNVk5PDl3OB?=
DU145 Mk\yT4lv[XOnIFHzd4F6 NGjyZo4zNjVizszN M1T4U|I1KGh? NHu4eW1FVVOR MnHuTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KHWycnXneYxifGmxbjDv[kBxOjG5YX[xJJBzd3SnaX6g[ZhxemW|c3nvci=> M2XQWFIzOjZyMU[2
DU145 NUeyd4VKU2mwYYPlJGF{e2G7 NGS3cnM2KM7:TR?= Mn;mNlQhcA>? NHjPZVJFVVOR NUHlOFB4UW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHjpd5RwdmViSESgZYNmfHmuYYTpc44> Mnz0NlIzPjBzNk[=
DU145 M4TDVGtqdmG|ZTDBd5NigQ>? M1e3VlUh|ryP MUGyOEBp NFnJVFNFVVOR M3nCTWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? MkLINlIzPjBzNk[=
786-0 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HnV|YvOiEQvF2= NGjJbII4OiCq MojqSG1UVw>? NHOybZBIUTVyPUOuNkDPxE1? M4LxfFIzPDN3Nk[5
A498 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjHXJdOPi5{IN88US=> MonWO|IhcA>? M3PYPGROW09? NUnrW49zT0l3ME2xMlYh|ryP NHfCd4ozOjR|NU[2PS=>
A549/ATCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7EOk4zKM7:TR?= Mkn6O|IhcA>? NFLmUolFVVOR NFnxRXJIUTVyPUGuOkDPxE1? MmHtNlI1OzV4Nkm=
ACHN M{nyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\5OmE3NjJizszN MX23NkBp NWeycJo{TE2VTx?= M4L0PWdKPTB;MT6zJO69VQ>? NHOyfZUzOjR|NU[2PS=>
BT549 NXn3UnJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFy5S|c3NjJizszN MknKO|IhcA>? NXizd3VYTE2VTx?= NH3ieVhIUTVyPUGuN{DPxE1? MVSyNlQ{PTZ4OR?=
EKVX NGP3fFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nWbVYvOiEQvF2= NWPNcGtFPzJiaB?= MXTEUXNQ MnPnS2k2OD1zLkOg{txO MXqyNlQ{PTZ4OR?=
HCT15 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS2T|FxPi5{IN88US=> MnnaO|IhcA>? M3zk[mROW09? NWPmTVNNT0l3ME2yMlUh|ryP NWr4WlNMOjJ2M{W2Olk>
HOP92 MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\sVHc3NjJizszN NGe0Umo4OiCq NIPET5NFVVOR MWHHTVUxRTRizszN MUOyNlQ{PTZ4OR?=
IGROV1 M{XH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L6flYvOiEQvF2= NI\tN2Q4OiCq MmnpSG1UVw>? MXvHTVUxRTFwMzFOwG0> MVOyNlQ{PTZ4OR?=
LOXIMVI MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG2Ok4zKM7:TR?= M{WwPFczKGh? MW\EUXNQ NXS0NG1NT0l3ME2xJO69VQ>? Mm\0NlI1OzV4Nkm=
M14 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\oOk4zKM7:TR?= Mn3NO|IhcA>? MV3EUXNQ NHn6OphIUTVyPUGuN{DPxE1? MXSyNlQ{PTZ4OR?=
MALME-3M M{XWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjmRW03NjJizszN NG\4ZVA4OiCq NU\UTJNyTE2VTx?= M3PnfGdKPTB;MD6zNkDPxE1? MmK5NlI1OzV4Nkm=
MCF10A M3zRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP6Ok4zKM7:TR?= NULReJFOPDhiaB?= M17EdmROW09? MVHHTVUxRTlwNjFOwG0> Mn\0NlI1OzV4Nkm=
MDA-MB-435 NVv1RmtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYi2MlIh|ryP M2e0WlczKGh? Mln4SG1UVw>? NUO1dJl7T0l3ME2wMlUh|ryP NYX6[FFWOjJ2M{W2Olk>
MDA-MB-468 M{G2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWW2MlIh|ryP NHOy[Y44OiCq MX;EUXNQ MorlS2k2OD1yLk[zJO69VQ>? NUTFNlBYOjJ2M{W2Olk>
MOLT4 M{jFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fhR|YvOiEQvF2= NXzMcnljPzJiaB?= Mn;ySG1UVw>? MXfHTVUxRTBwNDFOwG0> Mny2NlI1OzV4Nkm=
NCI-ADR-RES MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDP[JJ6Pi5{IN88US=> M36xNlczKGh? M4DucWROW09? MljlS2k2OD1yLkG2JO69VQ>? NVnOdVVTOjJ2M{W2Olk>
NCI-H23 NUTEWGlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC3Ok4zKM7:TR?= MkTEO|IhcA>? Mlf3SG1UVw>? MXLHTVUxRTFizszN NX;0dmRQOjJ2M{W2Olk>
NCI-H322M NVHsdow3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;ydlYvOiEQvF2= MUW3NkBp NHj6dFFFVVOR NHLTR4dIUTVyPUCuO|kh|ryP MYeyNlQ{PTZ4OR?=
NCI-H460 M1y5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXycY43NjJizszN M173[FczKGh? MXjEUXNQ NVLDXVRPT0l3ME2wMlc6KM7:TR?= MkDtNlI1OzV4Nkm=
NCI-H522 NEjWVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X1c|YvOiEQvF2= M33BZVczKGh? NGTEWIRFVVOR M{PaNWdKPTB;MD61JO69VQ>? NWDaUWZPOjJ2M{W2Olk>
OVCAR3 NUPIeldWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnNOk4zKM7:TR?= NH\KU5g4OiCq NGXTU2ZFVVOR NUXvO2NvT0l3ME2xMlMh|ryP M{m2SlIzPDN3Nk[5
OVCAR4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHBWYdIPi5{IN88US=> M2TXe|czKGh? M1K0c2ROW09? M2ntPGdKPTB;NDFOwG0> NUXjTWlDOjJ2M{W2Olk>
OVCAR5 NH\UfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO1fW9QPi5{IN88US=> NUjOTWhZPzJiaB?= M3;ZPGROW09? NGTpTXZIUTVyPUCuO|kh|ryP NE\JSXYzOjR|NU[2PS=>
OVCAR8 NUHKd5ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;LNIk3NjJizszN MmXPO|IhcA>? M36wOGROW09? Ml3LS2k2OD1yLkWg{txO M3X3b|IzPDN3Nk[5
RXF393 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MleyOk4zKM7:TR?= MVi3NkBp M3fsUWROW09? MXLHTVUxRTFwMzFOwG0> M330c|IzPDN3Nk[5
SF268 NFPqO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECxUmk3NjJizszN M3fFZ|czKGh? NVrxUYJPTE2VTx?= NXX6elZVT0l3ME2xMlYh|ryP NXrxW28zOjJ2M{W2Olk>
SF295 NYP0W|JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVWwb5pGPi5{IN88US=> M3PidlczKGh? NEnpWZVFVVOR M3rNTWdKPTB;MT62JO69VQ>? MYqyNlQ{PTZ4OR?=
SF539 M2XaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUK2MlIh|ryP MUW3NkBp NITTZ|JFVVOR NGPXUJBIUTVyPUKg{txO NF30OXEzOjR|NU[2PS=>
SK-MEL-2 NV\zR4NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWK0OmFNPi5{IN88US=> MVq3NkBp NFHkUItFVVOR Mk\rS2k2OD1zLkOg{txO NE[zSFAzOjR|NU[2PS=>
SK-MEL-28 M1r2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TuXVYvOiEQvF2= NW\GeG9DPzJiaB?= NGrIeGFFVVOR MXjHTVUxRTFizszN NIXVNVgzOjR|NU[2PS=>
SK-MEL-5 NIK4[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDXOk4zKM7:TR?= M3fBR|czKGh? M3LoWGROW09? Moi4S2k2OD1yLk[zJO69VQ>? NYfwNFFzOjJ2M{W2Olk>
SKOV3 NXGyV4l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HNZlYvOiEQvF2= M{HBNVczKGh? MYLEUXNQ M2\OR2dKPTB;MTFOwG0> M2X3elIzPDN3Nk[5
SN12C NHzqTVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUK2MlIh|ryP MUS3NkBp MnTtSG1UVw>? M3u2cmdKPTB;MjFOwG0> MUGyNlQ{PTZ4OR?=
SNB19 NFPFOnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTKOk4zKM7:TR?= MXW3NkBp NULxe2F2TE2VTx?= MWfHTVUxRTBwNkOg{txO MlewNlI1OzV4Nkm=
SNB75 NGnRWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYS2MlIh|ryP MVi3NkBp M32yN2ROW09? NHjCZ3pIUTVyPUCuO|kh|ryP NHru[pYzOjR|NU[2PS=>
SR NGL4NG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\sOk4zKM7:TR?= Moe2O|IhcA>? NYLySVZWTE2VTx?= NGe5UYhIUTVyPUCuOEDPxE1? Mm\RNlI1OzV4Nkm=
T47D M13OU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m4ZlYvOiEQvF2= NXnCbIxTPzJiaB?= M{\ZSGROW09? NIHMXFhIUTVyPUCuOUDPxE1? MkLuNlI1OzV4Nkm=
TK10 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP5cFg3NjJizszN M2PSbVczKGh? MnGySG1UVw>? NYDI[Hh{T0l3ME2wMlY{KM7:TR?= NG\Gc|MzOjR|NU[2PS=>
UACC257 M4\RXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[2MlIh|ryP MkXRO|IhcA>? NIn4THVFVVOR MoDLS2k2OD1yLkWg{txO NEjET|UzOjR|NU[2PS=>
UACC62 NYjVUXNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVi2MlIh|ryP M4WxdFczKGh? M2TvW2ROW09? MUnHTVUxRTBwNDFOwG0> MU[yNlQ{PTZ4OR?=
UO31 NFvCbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnsOk4zKM7:TR?= NFzB[pk4OiCq NXfXPYJNTE2VTx?= MUTHTVUxRTBwNTFOwG0> NU\K[4g5OjJ2M{W2Olk>
Hep3B M13yOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7BZVBtPDhiaB?= MlfhSG1UVw>? NFT2XJNIUTVyPUCuOlkh|ryP MYmyNlQ{QTh4Mx?=
BE(2)-C M1;Mb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLoN3VCPzJiaB?= NVTNfIFWTE2VTx?= M13lb2lEPzB;MjFOwG0> M1f2fFIzQTN{M{G2
Bel7402 NE[0VY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUW3NkBp M3nqO2ROW09? NWTDbo41T0l7ME2xO{DPxE1? MonVNlMxPjF|N{[=
Bel7404 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PBSFczKGh? NILxbpVFVVOR M4O0PGdKQTB;MUig{txO NVjtW5pjOjNyNkGzO|Y>
BGC823 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrSPGw4OiCq Mn\5SG1UVw>? MUXHTVkxRTdwNTFOwG0> M{jITFI{ODZzM{e2
MGC803 M1nRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUW3NkBp MWTEUXNQ NU\5VllnT0l7ME2xNE45KM7:TR?= MWeyN|A3OTN5Nh?=
SGC7901 NVf3[VZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXq3NkBp NVPj[Yx2TE2VTx?= NEm2SINIUTlyPUmuOEDPxE1? NY[4UlM1OjNyNkGzO|Y>
SKHEP1 MmTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDSbGVyPzJiaB?= NET0XopFVVOR Ml20S2k6OD1zNzFOwG0> M3;pUFI{ODZzM{e2
SMMC7721 NYXDfIRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW[3NkBp NE[0fZpFVVOR M3TIemdKQTB;MkCg{txO M3OyO|I{ODZzM{e2
NUGC3 NGnE[HFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\LNVAh|ryP NE\TZWtIUT1{Lkm0JO69VQ>? Mn7mNlMyPjN|M{K=
A2780 CisR M{nN[GtqdmG|ZTDBd5NigQ>? NGfzeHgyQCCq NWnBVnNuUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= NYXjR5pHOjN{NUK2NFM>
CAL27 sens MnS3T4lv[XOnIFHzd4F6 M{jpfFE5KGh? MX7Jcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwM{[g{txO NV\RfnFQOjN{NUK2NFM>
CAL27 CisR M{L4U2tqdmG|ZTDBd5NigQ>? MWixPEBp MljUTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M1\qc|I{OjV{NkCz
KYSE-510 CisR NVHFbVJHU2mwYYPlJGF{e2G7 M2XGcVE5KGh? NGjESHRKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP M4jLUVI{OjV{NkCz
KYSE-510 sens M3ThWWtqdmG|ZTDBd5NigQ>? Mo\FNVghcA>? MXnJcohq[mm2aX;uJI9nKEiGQVOge4l1cCCLQ{WwJI9nKDBwNzFOwG0> NWXLWolYOjN{NUK2NFM>
MDA-MB-231 sens NYPtTZU3U2mwYYPlJGF{e2G7 MWmxPEBp NGjRfYJKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NFnIfYIzOzJ3Mk[wNy=>
MDA-MB-231 CisR NEDxT4ZMcW6jc3WgRZN{[Xl? NYHmSHgyOThiaB?= MoPjTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M17mU|I{OjV{NkCz
ES2 M{fJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PYdlQ5KGh? NYjsOWduTE2VTx?= MmewTWM2OD1zMj63JO69VQ>? MoLoNlM1QTN2NEm=
MDA-MB-231 NVK1cXBRU2mwYYPlJGF{e2G7 MonWNVAh|ryP MU[zNEBucW5? NG[0VIpFVVOR NVntTXNJUW6qaXLpeIlwdiCxZjDISGFEOmF? MlTFNlM1QTN2NEm=
MDA-MB-231 M{DkbWtqdmG|ZTDBd5NigQ>? MmPvNUDPxE1? MYWyOEBp M{Lzc2ROW09? M2[weGlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiYXPleJlt[XSrb36gcIV3\Wy|IH;mJJR2[nWuaX6= M1fueVI{PDl|NES5
HS68 NUjXOHVWS3m2b4TvfIlkKEG|c3H5 MlPuNVAh|ryP MkTBO|IhcA>? NW\5T5N1TE2VTx?= MV7JR|UxRTRwNjFOwG0> NHK1SVIzOzV5MEW0Ni=>
MEF M13M[WN6fG:2b4jpZ{BCe3OjeR?= NGfv[ZUyOCEQvF2= M2L5RlczKGh? NXfpTFVMTE2VTx?= NETWd21KSzVyPUSuOEDPxE1? NXv3c2JrOjN3N{C1OFI>
BGC823 NFLydVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDpeFRFVVOR MWLHTVUxRTNwMEmg{txO NEWyeJozOzZyMUewOi=>
High5 M{PuZWtqdmG|ZTDBd5NigQ>? NUjH[Gk2OjRiaB?= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? NXH4O41YOjN4MEK1NlM>
High5 NELmZplMcW6jc3WgRZN{[Xl? MYqyOEBp NIHZU3lKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= MnHFNlM3ODJ3MkO=
High5 NFHVb2xMcW6jc3WgRZN{[Xl? M3;4flI1KGh? NFvxenFKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= Mn7ENlM3ODJ3MkO=
A549 M3TUOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XhUmROW09? NH74[HVKSzVyPUGuNFc6KM7:TR?= MUCyN|Y1PDJzMB?=
HCT116 NUGweYpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHi4TXBFVVOR MV7JR|UxRTBwN{W3JO69VQ>? MXqyN|Y1PDJzMB?=
K562 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjHOIdFVVOR MmP0TWM2OD1yLk[0OUDPxE1? MUeyN|Y1PDJzMB?=
GBC-SD NIPUc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWf6SoxxPSEQvF2= Mmi0O|IhcA>? NXrYdHQ2TE2VTx?= MX7JR|UxRTF2Lkig{txO Mnq3NlM4ODd{NkC=
HGC27 NV32dWJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXyOUDPxE1? M4DEblczKGh? NGnBV3hFVVOR NEK2e|RKSzVyPUWuOEDPxE1? NIXiclQzOzdyN{K2NC=>
HL60 MmPMT4lv[XOnIFHzd4F6 M3fUN|Uh|ryP M3qzPVI1KGh? NFv3c2tFVVOR MV7Jcohq[mm2aX;uJI9nKEiGQVO= MVqyN|cxPzJ4MB?=
Vero M371O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17KbFczKGh? Moq2SG1UVw>? MUHJR|UxRTBwOTFOwG0> NUP1XoJiOjN5OE[0OVI>
NCI60 MYnDfZRwfG:6aXOgRZN{[Xl? MoHpOFghcA>? NGnW[mRFVVOR NF;mXYtIUT1yLkWzJO69VQ>? NI[xXI4zPDBzNUOyOy=>
SW620 MlXsR5l1d3SxeHnjJGF{e2G7 M4qzVVQ5KGh? NXPxcZFpTE2VTx?= MWHHTV0xNjV2IN88US=> MWCyOFAyPTN{Nx?=
U251 MkfiR5l1d3SxeHnjJGF{e2G7 MknkOFghcA>? NF;PNYJFVVOR NFXwRVlIUT1zLkWzJO69VQ>? Mn7nNlQxOTV|Mke=
KM12 M3jrT2N6fG:2b4jpZ{BCe3OjeR?= M2HtV|Q5KGh? MlfOSG1UVw>? MlGwS2k:OS56ODFOwG0> NUe4[FJROjRyMUWzNlc>
Hs578T MVzDfZRwfG:6aXOgRZN{[Xl? NFTaZnA1QCCq MWPEUXNQ MYLHTV01Njh|IN88US=> NEf6cIwzPDBzNUOyOy=>
MDA-MB-231 NFvHbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13oV|Q5KGh? M4rDR2lEPTB;MD6xOkDPxE1? M2TyUFI1ODl3MEG2
MCF7 NHjIbFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX[0PEBp Mm[zS2k:OC52NTFOwG0> NHTlUHEzPDFzOUW1OS=>
MDA-MB-435 Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPIOIw1QCCq NXm0dnFRT0l;MD64PEDPxE1? NGrXb|czPDFzOUW1OS=>
AsPC1 NFHUVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUezNEDPxE1? NFrxSIs1QCCq NX;JZpljTE2VTx?= MoTLTWM2OD1|Lk[2JO69VQ>? Mo\aNlQyQDV|N{i=
Jurkat E6.1 NUTxW3NjU2mwYYPlJGF{e2G7 MW[yJIg> NHq2UodFVVOR MljZTY5pcWKrdHnvckBw\iCKRFHDOEB4cXSqIFnDOVAhd2ZiMD6wOEDPxE1? NFjpenIzPDJ4MUi2Ni=>
KG1 NGjiO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrJOFghcA>? NFry[GNKSzVyPUGuNVUh|ryP M1\MRVI1PTJ3MECz
HEL M1O3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUC0PEBp M33hUWROW09? NVTtZpFEUUN3ME2wMlQ6KM7:TR?= NEfreGMzPDZ7NEC1OS=>
HSC3 M3no[GN6fG:2b4jpZ{BCe3OjeR?= M4n1cFEzKGh? MlqxSG1UVw>? NWCxV|VGUUN3ME2wMlcyKM7:TR?= MUKyOFc3PjV4MB?=
HT-29 Mm\FR5l1d3SxeHnjJGF{e2G7 NH3DSpEyOiCq M4PRdmROW09? M{TSc2lEPTB;MD63NkDPxE1? NUTtWFZiOjR5Nk[1OlA>
KB NUXHcHFyS3m2b4TvfIlkKEG|c3H5 M{fsd|EzKGh? NIew[nBFVVOR NFi1[HZKSzVyPUCuO|Uh|ryP NEHlXFAzPDd4NkW2NC=>
H460 NYDEOHh[S3m2b4TvfIlkKEG|c3H5 NEXIOXoyOiCq MmrMSG1UVw>? NGr5RmdKSzVyPUCuPFIh|ryP NHjybWQzPDd4NkW2NC=>
MONE1 MoLxR5l1d3SxeHnjJGF{e2G7 NGPDUXQyOiCq MlGzSG1UVw>? MWDJR|UxRTFwMUig{txO NHfUcIMzPDd4NkW2NC=>
MKN45 NVfVb|ZoS3m2b4TvfIlkKEG|c3H5 Mni1NVIhcA>? NIP3OohFVVOR MmHCTWM2OD1zLkK1JO69VQ>? Mn7jNlQ4PjZ3NkC=
TSGH NGr5VWtEgXSxdH;4bYMhSXO|YYm= MmLqNVIhcA>? M1zoOWROW09? NETsNI9KSzVyPUKuNFkh|ryP M{f0NFI1PzZ4NU[w
HL60 M{PE[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{K3NFczKGh? MWTEUXNQ NFnFWGNIUTVyPUCuPVMh|ryP M1PmSVI1QTByNUCw
HEK293 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVO3NkBp MV;EUXNQ NEXRSo1IUTVyPUGzJO69VQ>? MnrmNlQ6ODB3MEC=
Jurkat M{PsbGN6fG:2b4jpZ{BCe3OjeR?= MYqxNFAh|ryP MXO3NkBp NYe0V2oyT0l3ME2wMlkh|ryP MnvmNlQ6ODB5NEO=
GM15850 NHvtSWtMcW6jc3WgRZN{[Xl? M3jTVVIvPSEQvF2= M4LxXVk3KGh? M3GzSmROW09? M3\vcYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> NIH2cXAyPjl{MUO2Oy=>
GM15850 M{jpbWtqdmG|ZTDBd5NigQ>? MV2yMlUh|ryP MoD2PVYhcA>? M2K3NGROW09? MWHkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= MXuxOlkzOTN4Nx?=
GM15850 MoHhT4lv[XOnIFHzd4F6 NWfxSZhNOi53IN88US=> MoG3PVYhcA>? NGX3UJRFVVOR MW\kc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= MXixOlkzOTN4Nx?=
GM15850 MoHXT4lv[XOnIFHzd4F6 MXuyMlUh|ryP NYPQdIJNQTZiaB?= M1LifGROW09? M{GxZYRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NXPVTlVMOTZ7MkGzOlc>
GM15850 NX2xW|JXU2mwYYPlJGF{e2G7 MUeyMlUh|ryP M2fkZ|k3KGh? M2nBWWROW09? NH;kUGhld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhQCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> Mn;WNVY6OjF|Nke=
GM15850 NGO2WWFMcW6jc3WgRZN{[Xl? MnjCNk42KM7:TR?= NV;QT3RJQTZiaB?= NXT5cZN3TE2VTx?= MmD6[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MkPENVY6OjF|Nke=
GM15850 MWjGeY5kfGmxbjDBd5NigQ>? MYG1JO69VQ>? MUixNkBp NXnoVnFvTE2VTx?= NGTKOI9p[XNibn:g[YZn\WO2IH;uJGZZViCvUl7BJIV5eHKnc4Ppc44> NEPPdnkyPjl{MUO2Oy=>
U937 MVHLbY5ie2ViQYPzZZk> MY[1JO69VQ>? M4XrdFI1KGh? Moe0SG1UVw>? MWjoZZMhdm9iZX\m[YN1KG:wIHHsdIhiKHS3YoXsbY4h[WOndInsZZRqd25? NFGxbIUyPzR2N{e1NC=>
U937 MUHLbY5ie2ViQYPzZZk> NELnNowyKM7:TR?= MVmyOEBp NXL0VVRuTE2VTx?= Ml;KbIF{KG6xIHXm[oVkfCCxbjDhcJBp[SC2dXL1cIlvKGGlZYT5cIF1cW:w MoLVNVc1PDd5NUC=
PANC1 MmCxSpVv[3Srb36gRZN{[Xl? NFS2enYyKM7:TR?= NHLJ[|MzPCCq NYjpVmdC\G:nczDuc5QhcW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> NHjJSGUyPzV6OEe0OC=>
PANC1 M320[2Z2dmO2aX;uJGF{e2G7 MYGxJO69VQ>? NXH2d5pxPDhiIHi= MVHkc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= MWexO|U5QDd2NB?=
Caco-2 Ml;4SpVv[3Srb36gRZN{[Xl? MWe1JO69VQ>? NEHlPW0zPCCq NVPx[45FTE2VTx?= MUDkc4V{KG6xdDDpcoR2[2ViUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> NFu2TowzODF2M{i0NC=>
SCC4 M3rPZWZ2dmO2aX;uJGF{e2G7 NHLMbGYyKM7:TR?= M1W4W|ExKG2rbh?= M16wN2ROW09? NV\peFVGcGG|IH7vJIFod26rc4SgZYN1cX[rdImgZZQhXkSUIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCFWWCyOEBo\W6nIHX4dJJme3Orb36= M2rXe|IxPDV{MkK1
A549 NEnoNWRHfW6ldHnvckBCe3OjeR?= NUTpWHZ3PSEQvF2= NI\QNmk{KGh? Ml3ySG1UVw>? NX;hTFVz\G:nczDuc5QhcW6mdXPlJIF2fG:yaHHnfUBie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|NKUQ>? NFzVTIEzODh3NUKwPC=>
HCT116 MnvUT4lv[XOnIFHzd4F6 NVnFXJY4OC5|IN88US=> MUSzNEBp MU\EUXNQ NH32OY5ld2W|IH7veEBqdmirYnn0JGhFSUNzIHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iCqaYP0c45mKEh|S{mgZYNmfHmuYYTpc44> NIT6SYkzOTB6ME[0Oy=>
HepG2 NYP2NZhwTnWwY4Tpc44hSXO|YYm= Mn7GNVAh|ryP M130fVI1KGh? MlzSSG1UVw>? M{XSS4Rw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhcHmyZYLhZ4V1gWyjdHnvckBw\iCyNUO= M{HHWVIyPTR6NUiy
GM11272 NGHOeJdHfW6ldHnvckBCe3OjeR?= Mn3iNE4yKM7:TR?= M3zFW|czKGh? MXfEUXNQ M3zFe4Rw\XNibn;0JJJm[WO2aY\heIUhVWWFcEKgcZV1[W62IHX4dJJme3Orb36= NGPPfXczOTh2MEexOi=>
MDA-MB-231 M4rJc2tqdmG|ZTDBd5NigQ>? NEf2cWMyOCEQvF2= NYfPSpg2PSCvaX6= M4[3RWROW09? MUnkc4V{KG6xdDDpcohq[mm2IFjERWMz[Q>? MX6yN|Q6OzR2OR?=
MDA-MB-231 M{i5PWtqdmG|ZTDBd5NigQ>? MWGxJO69VQ>? NYHnXnVFOjRiaB?= NYHiXmJGTE2VTx?= M4jKVoRw\XNibn;0JIlvcGmkaYSgTGRCSzZiYYPz[ZN{\WRiYYOgZYNmfHmuYYTpc44hdGW4ZXzzJI9nKHS3YoXsbY4> M1vVWlI{PDl|NES5
K562 MYHLbY5ie2ViQYPzZZk> NFnIOGdld2W|IH7veEBqdmirYnn0JGhFSUN? NVfFfGVpOjN3OUGxNVE>
Jurkat NU\EbpZyS3m2b4TvfIlkKEG|c3H5 NEW1SWQzOCEQvF2= NIXjXXQ4OiCq M{DvZ2ROW09? NUTmR41Ndm9iY4n0c5RwgGmlaYT5JIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9v NF;BTFMzPDNyNEO0PC=>
HCT116 NEjmUpZCeG:ydH;zbZMhSXO|YYm= NGPUeI0{KM7:TR?= NUnFbWhbOjRiaB?= NHTRT4FFVVOR MXvkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKHB3MzDwdo91\WmwIHzleoVt M4LJT|I1PzZ4NU[w
KASUMI-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTl7LkG3JI5O MlHUV2FPT0WU
KARPAS-45 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHexTW1KSzVyPUG3N{45QSCwTR?= M1LS[HNCVkeHUh?=
BHT-101 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnaSJBkUUN3ME2yOFQvOThibl2= NGjDVIVUSU6JRWK=
H9 NWDNZmhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCxcFBOUUN3ME2yOVUvODRibl2= M4jkZnNCVkeHUh?=
PA-1 MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPKb2pxUUN3ME2yPFYvOjZibl2= NHrueHNUSU6JRWK=
NEC8 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;qU49nUUN3ME2yPFkvOzhibl2= MXfTRW5ITVJ?
MHH-PREB-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjiWVhKSzVyPUK5OE42OyCwTR?= NG\0U4hUSU6JRWK=
NB7 MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWezeYxnUUN3ME2zOFUvPzRibl2= NX;4T4wyW0GQR1XS
A3-KAW MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTRyMD61PUBvVQ>? MYPTRW5ITVJ?
NB69 M{HqbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrqSpN6UUN3ME20NVEvPzFibl2= NWDHXIV{W0GQR1XS
EoL-1-cell MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTR3NEK1JI5O MVXTRW5ITVJ?
CHP-212 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\pPZRKSzVyPUS1O{42OyCwTR?= M136WXNCVkeHUh?=
C2BBe1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\BTWM2OD12N{KuNVkhdk1? MmLsV2FPT0WU
697 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fyd2lEPTB;NEezMlQyKG6P NIfo[WdUSU6JRWK=
BCPAP MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nLR2lEPTB;NUCxMlQzKG6P M3X5T3NCVkeHUh?=
L-363 NYjn[ZZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH62T2ZKSzVyPUWwN{4yKG6P NFXwU|VUSU6JRWK=
ES8 NVL3[2ttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33XN2lEPTB;NUKzMlU{KG6P MnPEV2FPT0WU
BE-13 NIfTSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jQN2lEPTB;NUK2Mlk3KG6P NVK0OW9DW0GQR1XS
CTB-1 NHXCPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7uPFdKSzVyPUWzO{46OiCwTR?= MmXQV2FPT0WU
HD-MY-Z MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[wSodkUUN3ME21N|gvOTNibl2= MnHGV2FPT0WU
NKM-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL5SHVXUUN3ME21OFQvOjdibl2= MWLTRW5ITVJ?
NCI-H720 NIXRRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;4eGlEPTB;NU[wMlE5KG6P NIPNTmFUSU6JRWK=
KY821 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjCTWM2OD13NkOuNlUhdk1? Mn72V2FPT0WU
OVCAR-5 MkLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTV5Nj6xNUBvVQ>? Mo\tV2FPT0WU
CTV-1 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTV6MT61OkBvVQ>? Mn;YV2FPT0WU
P12-ICHIKAWA MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTV7Nj61NUBvVQ>? M33Fb3NCVkeHUh?=
DB MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\CdmlEPTB;NUm4MlU4KG6P NIThZmtUSU6JRWK=
CHL-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzYVZBKUUN3ME22OFIvODhibl2= MlzkV2FPT0WU
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COLO-320-HSR MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq3SphDUUN3ME2xMlg5OTl5IN88US=> NYS0[Ih3W0GQR1XS
HN NVTZZm02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X3TmlEPTB;MT64PFczPSEQvF2= M33YXHNCVkeHUh?=
HT Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXs[FhKSzVyPUGuPFg6PDdizszN M1;qZnNCVkeHUh?=
LoVo NF7jPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXLTWM2OD1zLki5PFEh|ryP NFT3TYRUSU6JRWK=
CGTH-W-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPoTWM2OD1zLki5PVQ3KM7:TR?= MVzTRW5ITVJ?
NB6 MnviS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwOUGyPVgh|ryP M2PKVnNCVkeHUh?=
EW-22 NGfPTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj1TWM2OD1zLkmyPFg4KM7:TR?= MULTRW5ITVJ?
ES6 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjpcZdKSzVyPUGuPVM3OzFizszN M2nzTXNCVkeHUh?=
SCC-15 M4PkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\RZWlEPTB;MT65N|gyQSEQvF2= MnPQV2FPT0WU
HL-60 M{TB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFWyNHlKSzVyPUGuPVM6ODJizszN MoLOV2FPT0WU
human HOP-92 M1vaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjYTWM2OD1zLkm0NFY2KM7:TR?= NIPweXdUSU6JRWK=
SW626 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j5NmlEPTB;MT65OFg6QSEQvF2= NYriWmpNW0GQR1XS
HEC-1 M373[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXZTWM2OD1zLkm1N|Yh|ryP NXjqPW5VW0GQR1XS
LB2241-RCC M1vpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvmTWM2OD1zLkm4NlMyKM7:TR?= M2HERXNCVkeHUh?=
Ramos-2G6-4C10 M4LrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nBe2lEPTB;MT65PVQ6OyEQvF2= NX6zWWg2W0GQR1XS
A101D MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkW0TWM2OD1{LkKwN|A{KM7:TR?= Mne3V2FPT0WU
NCI-H446 NHnCVmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\uVIRKSzVyPUKuNFQ2QTlizszN M{L1bXNCVkeHUh?=
SBC-5 M3WwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TFU2lEPTB;Mj6wOlE1PyEQvF2= M{nYbnNCVkeHUh?=
HOS NWXXNm5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJwMEe2OVMh|ryP Ml3vV2FPT0WU
K5 NEDRO5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPGTWM2OD1{LkC3PFEyKM7:TR?= MYrTRW5ITVJ?
HLE MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHmwTnNKSzVyPUKuNFg2OjlizszN MmLJV2FPT0WU
HSC-2 NYn4e5B5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXaTWM2OD1{LkGyPFk5KM7:TR?= NX30fVJOW0GQR1XS
LCLC-97TM1 NWf0OJlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwMUS1PFMh|ryP M4HkfHNCVkeHUh?=
DMS-273 NYezZWd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoG4TWM2OD1{LkG0PFM4KM7:TR?= MULTRW5ITVJ?
TE-8 MmHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHHd49KSzVyPUKuNVU4PjVizszN M4XMbnNCVkeHUh?=
DSH1 M4PQOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuxUnBqUUN3ME2yMlE3Ozl6IN88US=> MoHGV2FPT0WU
CAL-51 NF3TR29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7Ubo1sUUN3ME2yMlE3Pjl7IN88US=> MYjTRW5ITVJ?
IST-SL1 NVS2e|dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3zeldKSzVyPUKuNVY5PDRizszN NEe4XHdUSU6JRWK=
GCT M1;Wb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFv4S5dKSzVyPUKuNVc4PyEQvF2= MV;TRW5ITVJ?
SW948 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrB[o41UUN3ME2yMlE5PDV4IN88US=> MWLTRW5ITVJ?
NOMO-1 M{\XZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfDTWM2OD1{LkG5N|E4KM7:TR?= MkHRV2FPT0WU
C8166 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vP[2lEPTB;Mj6yNVM{PCEQvF2= M{DqXXNCVkeHUh?=
OC-314 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwMkOyOVkh|ryP NVv6PGdGW0GQR1XS
CAL-39 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPrTWM2OD1{LkKzOlI3KM7:TR?= MkjqV2FPT0WU
MDA-MB-453 NUXkS|IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwMkSyO|Uh|ryP MWfTRW5ITVJ?
A673 NIXaWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln4TWM2OD1{LkK1PFYzKM7:TR?= MVfTRW5ITVJ?
HTC-C3 NFfte45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknVTWM2OD1{LkK2PFUh|ryP NH\hU3FUSU6JRWK=
NCI-H1666 MkPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfhcnRKSzVyPUKuNlgyOTFizszN NYTGOXRPW0GQR1XS
PSN1 MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvHTWM2OD1{LkK4PVE{KM7:TR?= NUL5TINkW0GQR1XS
GI-1 NVHPRW9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrOTWM2OD1{LkOwOVQ{KM7:TR?= MVXTRW5ITVJ?
HuH-7 NYH4ZXNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPXbVZwUUN3ME2yMlMxPjN5IN88US=> NULpV2p6W0GQR1XS
JAR MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr1Om46UUN3ME2yMlMyQTh5IN88US=> M3PLbXNCVkeHUh?=
5637 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nCNmlEPTB;Mj6zNlEzQSEQvF2= NFm1fGhUSU6JRWK=
GB-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLMTXNbUUN3ME2yMlMzOzN3IN88US=> NHnRcVhUSU6JRWK=
KP-N-YS NIXRSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7sTWM2OD1{LkOyOlE2KM7:TR?= NFf3PYhUSU6JRWK=
OAW-42 NGLnboVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z5RWlEPTB;Mj6zN|QyPiEQvF2= NGfRSJBUSU6JRWK=
8-MG-BA M2qyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj1U3dQUUN3ME2yMlM{QTB4IN88US=> NYHp[2JJW0GQR1XS
RH-18 NXLQXXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PWcGlEPTB;Mj6zOVAzOiEQvF2= MknxV2FPT0WU
NCI-H1155 NFTHblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O0ZmlEPTB;Mj6zOlczPSEQvF2= M2LnSXNCVkeHUh?=
NB17 NFXZOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zOPWlEPTB;Mj6zPFI1OyEQvF2= MnnKV2FPT0WU
NCI-H1437 MoTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7YSnFoUUN3ME2yMlQyQDd|IN88US=> MUnTRW5ITVJ?
SN12C NWjBR|ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rHPGlEPTB;Mj60N|IyPCEQvF2= M1PHSXNCVkeHUh?=
HSC-3 NGPwdVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPaW3g3UUN3ME2yMlQ1PTB7IN88US=> MU\TRW5ITVJ?
GAMG NX3RNlRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfXSog{UUN3ME2yMlQ1PTZzIN88US=> NHvvSpFUSU6JRWK=
HT-1080 NGiwTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi5OIpIUUN3ME2yMlQ1QDZ2IN88US=> MmLrV2FPT0WU
A549 NXfLfmFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[2ZmlEPTB;Mj60OFg6OyEQvF2= MkLjV2FPT0WU
KNS-62 M2\tVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[yTWM2OD1{LkS1NFYyKM7:TR?= M2XQXnNCVkeHUh?=
YKG-1 MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXXU3U2UUN3ME2yMlQ2PDN5IN88US=> NVzSZ5VIW0GQR1XS
LU-134-A M2\yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTJwNEewNFgh|ryP NH3abWdUSU6JRWK=
FADU NEjXdYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJwNEexOlIh|ryP NGizcnRUSU6JRWK=
TGBC11TKB M1PPNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrpTWM2OD1{LkS3NVc4KM7:TR?= M3XL[HNCVkeHUh?=
HT-3 NGPOUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorGTWM2OD1{LkS5OVM2KM7:TR?= NX\ITYppW0GQR1XS
NCI-H2170 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLZ[FhKSzVyPUKuOVA2PDlizszN M1\hbnNCVkeHUh?=
Mo-T MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJwNUC5Nlch|ryP NIroc3FUSU6JRWK=
CCRF-CEM M2m1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJwNUOwOFMh|ryP NVzhNW1FW0GQR1XS
KU-19-19 M{TRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3NTWM2OD1{LkWzOVE{KM7:TR?= M4H1SXNCVkeHUh?=
NCI-H1048 NWf1PGFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTJwNUWwNlUh|ryP MnizV2FPT0WU
KOSC-2 MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rKbmlEPTB;Mj61OlA4PiEQvF2= M{T1fXNCVkeHUh?=
A431 M1XqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwNU[zN|Uh|ryP NVS5SoNMW0GQR1XS
COR-L23 NHG4[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITEdHhKSzVyPUKuOVg2PjZizszN NInTUohUSU6JRWK=
MKN28 NWe0TmhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnMXHdKSzVyPUKuOVkxOzdizszN MojLV2FPT0WU
22RV1 NXzOXHA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFToVHJKSzVyPUKuOVkzPzRizszN NXXmWlRjW0GQR1XS
ABC-1 Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTvRodpUUN3ME2yMlYxPDZizszN NVyybWtlW0GQR1XS
NCI-H2126 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;o[mlEPTB;Mj62NFk5PCEQvF2= MlKyV2FPT0WU
DoTc2-4510 M3TYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XFdGlEPTB;Mj62NlE5PSEQvF2= M131VHNCVkeHUh?=
SCC-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknYTWM2OD1{Lk[zNFEzKM7:TR?= M3TDeXNCVkeHUh?=
NCI-H661 M2XvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnHcVQ1UUN3ME2yMlY1ODh3IN88US=> MU\TRW5ITVJ?
RPMI-2650 NUD6WlU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV:3bXZpUUN3ME2yMlY1OTR|IN88US=> NEWzWHRUSU6JRWK=
NCI-H510A NHu5XFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr2TWM2OD1{Lk[0OFI3KM7:TR?= NUKyZlhyW0GQR1XS
BPH-1 M{D5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJwNkW4OUDPxE1? MlW0V2FPT0WU
M14 NEPGdpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L6SmlEPTB;Mj62Olk6OyEQvF2= MWfTRW5ITVJ?
G-402 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\iTWM2OD1{LkewOFUyKM7:TR?= NEjvd2RUSU6JRWK=
AsPC-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv6c21KSzVyPUKuO|EyPyEQvF2= MknpV2FPT0WU
NB12 NGPJVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJwN{G3NUDPxE1? NHr2PHhUSU6JRWK=
SK-HEP-1 MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJwN{SzPVEh|ryP NFWyNGVUSU6JRWK=
U-266 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL3fIFVUUN3ME2yMlc4OTJzIN88US=> MVzTRW5ITVJ?
AM-38 NWXIfJgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOzN3BMUUN3ME2yMlc4OzV3IN88US=> NWTaXlkxW0GQR1XS
PC-14 NWXY[WZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\U[WJKSzVyPUKuPFA2OSEQvF2= M2rrOXNCVkeHUh?=
EGI-1 M1u5SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXuTWM2OD1{LkixO|Q{KM7:TR?= NWnpXWRVW0GQR1XS
LS-411N MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jrbWlEPTB;Mj64NlM{KM7:TR?= M33oOnNCVkeHUh?=
BFTC-905 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELaem9KSzVyPUKuPFU2OjNizszN NYDtb2JVW0GQR1XS
CaR-1 NVvYWnRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwOE[g{txO MmG1V2FPT0WU
NCI-H292 M1y3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyzTWM2OD1{Lki2OVk3KM7:TR?= MYLTRW5ITVJ?
8305C NIOzbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vpNmlEPTB;Mj64OlY1PSEQvF2= MVXTRW5ITVJ?
SNU-449 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\HeGlEPTB;Mj64PVE5OiEQvF2= NWrTR49YW0GQR1XS
LCLC-103H Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvINnA{UUN3ME2yMlkxPDN6IN88US=> NETUfFBUSU6JRWK=
SW1573 NV7tXWE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV34T2dOUUN3ME2yMlk3ODh{IN88US=> NGDQVG9USU6JRWK=
MLMA MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonNTWM2OD1{Lkm2O|E4KM7:TR?= NGfjVXBUSU6JRWK=
NCI-H1355 M4TSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nqTGlEPTB;Mz6wNFc6PiEQvF2= MYPTRW5ITVJ?
RMG-I MkLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHmTWM2OD1|LkCyOVkzKM7:TR?= MYLTRW5ITVJ?
BB65-RCC NFPZPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPFO2ZKSzVyPUOuNFM{OTRizszN M4HYWnNCVkeHUh?=
PC-3 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoraTWM2OD1|LkCzPFc1KM7:TR?= MULTRW5ITVJ?
SF268 M3XQXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTNwMES1NlMh|ryP M4nKdHNCVkeHUh?=
NCI-H810 MlXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\aVXZKSzVyPUOuNFQ5OjNizszN MVjTRW5ITVJ?
MEG-01 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT5TWM2OD1|LkC2NVY1KM7:TR?= M2\0c3NCVkeHUh?=
SW13 NXLuOIs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTNwMEe4OFch|ryP MWLTRW5ITVJ?
RH-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvsSYQzUUN3ME2zMlExOjd6IN88US=> M1\aUXNCVkeHUh?=
GT3TKB M{G2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;s[nVKSzVyPUOuNVEzQDNizszN Ml7NV2FPT0WU
TK10 NWOy[453T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHOU4RKSzVyPUOuNVM4OjRizszN MX7TRW5ITVJ?
T-24 NXnCe3NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj1TWM2OD1|LkG1NFch|ryP Mlr2V2FPT0WU
A498 MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrLeZZNUUN3ME2zMlIxQDdzIN88US=> Ml7mV2FPT0WU
GR-ST NWXnfVl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNwMkKxN|kh|ryP M3XjOXNCVkeHUh?=
LB2518-MEL MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HnbGlEPTB;Mz6yNlM6QCEQvF2= M4Cy[nNCVkeHUh?=
T47D M3fzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwMkO2Nlch|ryP NXzhUlN7W0GQR1XS
NCI-H1651 M2rYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rVXmlEPTB;Mz6yOFY1PCEQvF2= NX\6RlA1W0GQR1XS
EC-GI-10 NXLW[nFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\N[IpKSzVyPUOuNlYyPTNizszN M{nUbXNCVkeHUh?=
HT-29 NGPUfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTNwMk[2NVQh|ryP NFjwfm9USU6JRWK=
GI-ME-N NWXCOlNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vq[WlEPTB;Mz6yPVUyOSEQvF2= Mmi5V2FPT0WU
SW756 NYTDfmNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7xNVNKSzVyPUOuNlk3OjlizszN MW\TRW5ITVJ?
RKO NWi3bJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\pZW5qUUN3ME2zMlMxPzV5IN88US=> NV;JVItnW0GQR1XS
NCI-H1563 M3v6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTNwM{OwNVgh|ryP NIL1NJJUSU6JRWK=
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SW1417 NXewRm02T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fhbGlEPTB;MkWuNlQ6QCEQvF2= MXLTRW5ITVJ?
NCI-H82 M3fEdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TVbWlEPTB;Mk[uOFI5QCEQvF2= MWjTRW5ITVJ?
COLO-678 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fLV2lEPTB;MkeuOFkyQSEQvF2= M{HXWHNCVkeHUh?=
KURAMOCHI MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzQTWM2OD1{OD6xNlYh|ryP MlrkV2FPT0WU
NCI-H1650 NELjXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBVWlEPTB;M{CuNVkzPCEQvF2= NXXTSIlQW0GQR1XS
HCC1954 NF22dIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K2eGlEPTB;M{GuN|Y3PiEQvF2= Mn[0V2FPT0WU
GAK M4\zZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7jXWxKSzVyPUOyMlI3OTZizszN MWTTRW5ITVJ?
YAPC NWfGTpVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTN|Lke2OFgh|ryP NInj[pBUSU6JRWK=
NCI-H2228 NX\XOoh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofwTWM2OD1|ND6zOlA2KM7:TR?= NFLoOmhUSU6JRWK=
VMRC-RCZ M2\xcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjJOYx5UUN3ME2zOk4{ODJ{IN88US=> NILzcoFUSU6JRWK=
NMC-G1 M4D1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzETWM2OD1|Nz6wOVI6KM7:TR?= NYLLNnFIW0GQR1XS
D-336MG NUKxfnVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInwXFZKSzVyPUSxMlg1PDJizszN MYHTRW5ITVJ?
UACC-62 NF[1PYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXG[VFKSzVyPUSyMlU2ODVizszN M1HvdHNCVkeHUh?=
C-33-A NFXyUVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;zS2lEPTB;NEWuN|I2PiEQvF2= MWrTRW5ITVJ?
HCC1937 NVnpV4ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTNTWM2OD12Nz6xPVU5KM7:TR?= M4K1Z3NCVkeHUh?=
HDLM-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\MTWM2OD12Nz6yNlg4KM7:TR?= MlnJV2FPT0WU
NCI-H727 NVq3SYV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LyT2lEPTB;NEeuNlQ2OSEQvF2= MkLzV2FPT0WU
NY MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXjTYlMUUN3ME20PU4{QTB6IN88US=> NUjnW|FzW0GQR1XS
NCI-H2291 M2\nZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlizTWM2OD12OT64N|AyKM7:TR?= M{L2dHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

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Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

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  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms MK0683
Smiles ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

Bio Calculators

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Suspended Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID