Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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In DMSO USD 191 In stock
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Cited by 182 Publications

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M{DBOmtqdmG|ZTDBd5NigQ>? M3LsVlEhcA>? MWDEUXNQ NITWWJNidnSrLVjERWMyKGGldHn2bZR6KHerdHigTWM2OCCxZjCwMlEyOiEQvF2= M{\qdVEyQTZyNEi5
Friend leukemic cell MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrrSpBlPTBizszN NYLxe|VnPzJiaB?= NGe5OZNFVVOR MXPJR|UxRTBwOUmg{txO NUPESY1uOTJzMEm5NVM>
K562 NGjTWo9McW6jc3WgRZN{[Xl? NIm1eJo3KGh? NVnYUHpjTE2VTx?= M1nZWGlvcGmkaYTpc44hd2ZiaIXtZY4hcGm|dH;u[UBl\WGlZYT5cIF{\SBqbXn4eJVz\SCxZjDISGFEOSCjbnSgTGRCSzJrIIfpeIghUUN3MDDv[kAxNjBzIN88US=> M1\hZ|EzPDF7M{iw
HT1080 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH6O|IhcA>? M1XrdGROW09? NF7kcG5KSzVyPUKuOEDPxE1? M{jOSlEzOjdyMUe1
H1299 MV7LbY5ie2ViQYPzZZk> M3HiXFIxKG2rbh?= MoTKSG1UVw>? NEK5cmpKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhUESDQzDlcpp6dWVid3n0bEBKSzVyIH;mJFAvOTl2IN88US=> MVWxOFUzOTR{Mh?=
H1299 M{TnXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrZPJlMPzJiaB?= NYXBUo5pTE2VTx?= MX;JR|UxRTdwMkSg{txO NF62UmQyPDV{MUSyNi=>
HeLa MYfLbY5ie2ViQYPzZZk> NULySIN7OzBibXnu MmXSTY5pcWKrdH;yfUBkd26lZX70doF1cW:wIHHnZYlve3RiaHnzeI9v\SCmZXHj[ZR6dGG|ZTD3bZRpKEmFNUCgc4YhOC5{ODFOwG0> NYDqcmlyOTV4MEO5OFk>
LOX-IMVI MnrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HwW|Q5KGh? NIrzfIZKSzVyPUGuN{DPxE1? MVixOVcyPTR5MB?=
NCI-H226 M{e5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfoT2RiPDhiaB?= Mk\NTWM2OD1{Lk[g{txO NHLPWVMyPTdzNUS3NC=>
RXF-631L NXu1eHFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT1OFghcA>? NFvmN4lKSzVyPUKg{txO NUe5V2t6OTV5MUW0O|A>
SNB-78 M2OwXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL5OFghcA>? MXfJR|UxRTF4IN88US=> MUixOVcyPTR5MB?=
St-4 NInLWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYe0PEBp NWLWPGs{UUN3ME21MlIh|ryP MVqxOVcyPTR5MB?=
ARP1 M2rORmZ2dmO2aX;uJGF{e2G7 MWWyJO69VQ>? NF3MSHQ3KGh? NITwTFFKdmS3Y4Tpc44hd2ZiUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MoXDNVQ4OzR6ME[=
CEM MYnLbY5ie2ViQYPzZZk> NEH0fGwyKGh? M3vTbWROW09? M1rUfGlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zN{DPxE1? MYexOlQzODB4NB?=
HCT15 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmSyOFghcA>? M1fqfmdKPTB;MD64NkDPxE1? M2jofVE3PzJ|MkK3
NCI-H23 NYPzTGdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFKyWJo1QCCq NGjvPZpIUTVyPUCuPVIh|ryP NI\2VXcyPjd{M{KyOy=>
GM15850 NHvhc|VMcW6jc3WgRZN{[Xl? NGPyWoMzNjVizszN MV[5OkBp MYPEUXNQ MlXUTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSEOgcJl{cW6nIEG0JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n MUGxOlkzOTN4Nx?=
GM15850 NEDWdZZMcW6jc3WgRZN{[Xl? NETZPG4zNjVizszN MUW5OkBp M3vIUWROW09? MorZTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHjpd5RwdmViSESgcJl{cW6nIEWgZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? NED0OHYyPjl{MUO2Oy=>
GM15850 MkmwT4lv[XOnIFHzd4F6 NUjrUmtpOi53IN88US=> NUG5XYlYQTZiaB?= M1ryW2ROW09? NYDr[lNoUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFEzKGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l M3WzNFE3QTJzM{[3
GM15850 MX3LbY5ie2ViQYPzZZk> M4HkTFIvPSEQvF2= MXG5OkBp NGPUPWRFVVOR NFfhPJdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgPUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NI\yN2UyPjl{MUO2Oy=>
GM15850 MnTKT4lv[XOnIFHzd4F6 NFm0b2UzNjVizszN M3HTVVk3KGh? NXrXTlZVTE2VTx?= M4r5OWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n NFXGXlIyPjl{MUO2Oy=>
GM15850 NUTpfIhUU2mwYYPlJGF{e2G7 MWKyMlUh|ryP NEXhNVc6PiCq M4LRbmROW09? NUPGWZZxUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFE3KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l MVyxOlkzOTN4Nx?=
U937 MV;GeY5kfGmxbjDBd5NigQ>? NYfVdIZ4PSEQvF2= MorkNlQhcA>? NHnGNHNFVVOR M1rZTmNmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? MYixO|AxPDdzOB?=
H661 M{D5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{GzTVQ5KGh? MnXUTWM2OD1zIN88US=> NUPOOmxFOTdzNUewNFk>
U937 Mmf2SpVv[3Srb36gRZN{[Xl? NXzB[pdvPSEQvF2= M{CzSlI1KGh? M1y5fWROW09? M{LacGlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= MnLnNVc1PDd5NUC=
U937 NX:0bWtwTnWwY4Tpc44hSXO|YYm= MlnYNUDPxE1? M1LyR|I1KGh? NES2TXBFVVOR M1y0bWVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u MnvQNVc1PDd5NUC=
RAW264.7 NF;6O4lHfW6ldHnvckBCe3OjeR?= NI\YcFQyOCEQvF2= MnzlNlRp NWf2dlBmf2G2ZYK= M1jiZ2lvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEheHKxZIXjeIlwdiC5aYToJGlEPTBib3[gNE44PiEQvF2= MXmxO|Q4PzVzOB?=
RAW264.7 Mo[xSpVv[3Srb36gRZN{[Xl? NIDYPYMyOCEQvF2= MoDDNlRp MXj3ZZRmeg>? MnXlTY5pcWKrdHnvckBw\iCOUGOtd5RqdXWuYYTl[EBPVyCycn;keYN1cW:wIIfpeIghUUN3MDDv[kAyNjh6IN88US=> MkTyNVc1Pzd3MUi=
SC9 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYm0PEBp M{jVZ2lEPTB;MD62NFYh|ryP MmW2NVc2ODd{MUm=
ST14A MWLGeY5kfGmxbjDBd5NigQ>? NGnQdnU2KG6P MnS1O|IhcA>? NXP0PWduUW6lcnXhd4UhcW5iUlXTWE9PWlOIIH3SUmEh\XiycnXzd4lwdg>? MUCxO|U3PTl7Mx?=
ST14A M{PjN2Z2dmO2aX;uJGF{e2G7 MmjTOUBvVQ>? NFLPc3Q4OiCq MlXVTY5kemWjc3WgbY4hTTKIMTDtVm5CKGW6cILld5Nqd25? NFzvPGIyPzV4NUm5Ny=>
PANC1 NFH4eGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:yb3lqOSEQvF2= M1nQXWlEPTB;MD60OUDPxE1? MWSxO|U5QDd2NB?=
PANC1 NFHwcHBHfW6ldHnvckBCe3OjeR?= NFPvOVQyKM7:TR?= MomzNlQhcA>? M3nRbWlv[3KnYYPlJIlvKHB{MWfBSlEwS0mSMTDn[Y5mKGW6cILld5Nqd25? NEe2U4kyPzV6OEe0OC=>
PANC1 NFfafIhHfW6ldHnvckBCe3OjeR?= NHPzTIEyKM7:TR?= MkXmNlQhcA>? NVPKVIFnUW6lcnXhd4UhcW5icEK3b4lxOSCpZX7lJIV5eHKnc4Ppc44> MWexO|U5QDd2NB?=
PT45 Mn3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTBdYxKSzVyPUSg{txO MW[xO|U5QDd2NB?=
ACHN NX3JUpdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnBemlvOjFiaB?= NELaZVRIUTVyPUCuOlUh|ryP MofoNVc3PjJ4ME[=
PC3 NFe1VpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTqWZU3OjFiaB?= NIjNZZBIUTVyPUCuO|Eh|ryP M3vFTlE4PjZ{NkC2
A431 NInyNnBEgXSxdH;4bYMhSXO|YYm= M3X4VVczKGh? NX35c4tGUUN3ME20MlIh|ryP NIPSPWQyPzZ7MUe2Ny=>
Cal27 M1m3e2N6fG:2b4jpZ{BCe3OjeR?= NXnGUY5RPzJiaB?= NEDud|dKSzVyPUOuNkDPxE1? MUWxO|Y6OTd4Mx?=
CCRF-CEM M1y3Z2N6fG:2b4jpZ{BCe3OjeR?= MUi3NkBp NUS3cnFsUUN3ME2wMlgh|ryP NF;ySpoyPzZ7MUe2Ny=>
EOL1 NGPLeHREgXSxdH;4bYMhSXO|YYm= M4C2[lczKGh? NYLqXVZ1UUN3ME2xJO69VQ>? NVXCdnVsOTd4OUG3OlM>
Hec-1-A NGPXcldEgXSxdH;4bYMhSXO|YYm= MlfXO|IhcA>? NV6w[3RYUUN3ME2xJO69VQ>? NEnve5gyPzZ7MUe2Ny=>
HeLa MVfLbY5ie2ViQYPzZZk> Mlf6NVAh|ryP M4G3NlMxKG2rbh?= MoTBSG1UVw>? NHyxfG5KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGhFSUNzIIfpeIghUUN3MDDv[kAxNjB{IN88US=> MY[xO|Y6OTd4Mx?=
RKOp21 M1rPUmN6fG:2b4jpZ{BCe3OjeR?= NX7rVIFSPzJiaB?= NXXyNlc5UUN3ME2xMlc3KM7:TR?= NV25eIdJOTd4OUG3OlM>
Saos2 NUjrPYNOS3m2b4TvfIlkKEG|c3H5 NHP5cmY4OiCq M1f1O2lEPTB;Mj6zJO69VQ>? MlXrNVc3QTF5NkO=
SK-OV-3 M1PKdGN6fG:2b4jpZ{BCe3OjeR?= NEL3R2E4OiCq MUHJR|UxRTJwMjFOwG0> M3vWdVE4PjlzN{[z
U87MG NGDYOoREgXSxdH;4bYMhSXO|YYm= NWnmcXA2PzJiaB?= NHXhelZKSzVyPUGxJO69VQ>? MWWxO|Y6OTd4Mx?=
NUGC3 NIXwToVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIGxVXI2KM7:TR?= Ml\NNlQhcA>? MUXHTVUxRTJwN{mg{txO MlrnNVc6ODR6NEO=
CCD1059SK M1:wdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXVZoZKSzVyPUSzMlUh|ryP MUSxPFI1PzV3NB?=
HepG2 NV7OTpdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXhTWM2OD1yLkCwNFYh|ryP MmPmNVgzPDd3NUS=
HT1080 NISxT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMECyOEDPxE1? M2HzVVE5OjR5NUW0
SKBR3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PzZmlEPTB;MD64JO69VQ>? MVexPFI1PzV3NB?=
SNB78 NGr2V4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\iSWM2OD1zNjFOwG0> M3rlflE5OjR5NUW0
SQ20B M2G5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;OemlEPTB;MzFOwG0> NWj4fJZNOTh{NEe1OVQ>
St4 M{LtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\FR|UxRTVwMjFOwG0> NUTsS4VkOTh{NEe1OVQ>
MCF7 NFfKNIpHfW6ldHnvckBCe3OjeR?= Mli0NVAh|ryP M3nIWlghcA>? MVrEUXNQ NGrSS3ZKdmS3Y4Tpc44hd2ZidIXieYxqdiCqeYDldoFk\XS7bHH0bY9v NV7TS2JSOTh{NkmyNlY>
HEK293 NHjlSJNMcW6jc3WgRZN{[Xl? NH64OGIyKGh? Mln4SG1UVw>? NFToXHVKdmirYnn0bY9vKG:oIFjERWMyKHerdHigTWM2OCCxZjCwMlA{KM7:TR?= NXzBT5R3OTh|MEi1OlM>
HEK293 MVXLbY5ie2ViQYPzZZk> MVWxJIg> M{P1R2ROW09? NXq0OW9NUW6qaXLpeIlwdiCxZjDISGFEOyC5aYToJGlEPTBib3[gNE4xPTdizszN MU[xPFMxQDV4Mx?=
G401 NULVcIRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPoXI04OiCq MYHEUXNQ NXPCcJQ1UUN3ME2xJO69VQ>? MUixPFM4ODN5Mx?=
HeLa NGfEemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37OXVczKGh? MUHEUXNQ MVLJR|UxRTBwNE[g{txO MlTwNVg{PzB|N{O=
Human renal epithelial cell NWjHOZE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWW3NkBp NF;5O25FVVOR M4L5cWlEPTB;MUSg{txO MVKxPFM4ODN5Mx?=
U937 M4fYZ2Z2dmO2aX;uJGF{e2G7 M2HHbVUh|ryP MWKyOEBp NGqxU5pKdmS3Y4Tpc44hd2ZiaHnzeI9v\SCKNDDofZBmemGlZYT5cIF1cW:w MXGxPFM5OTJ|OB?=
U937 NUH6U2lxTnWwY4Tpc44hSXO|YYm= NInXXWc2KM7:TR?= MWSyOEBp NHLBN3BKdmS3Y4Tpc44hd2ZiYXzwbIEhfHWkdXzpckBpgXCncnHj[ZR6dGG2aX;u NEnOOFgyQDN6MUKzPC=>
U937 Ml[2SpVv[3Srb36gRZN{[Xl? MWK1JO69VQ>? M4LSPFI1KGh? MmPuTY5lfWO2aX;uJI9nKHB{MTDlfJBz\XO|aX;u MV6xPFM5OTJ|OB?=
U937 MkSzSpVv[3Srb36gRZN{[Xl? M1LrNlUh|ryP NE\XS48zPCCq NU\nV2pYUW6mdXP0bY9vKG:oIHHwc5B1d3Orcx?= NFS2V2UyQDN6MUKzPC=>
U937 NGnCToVHfW6ldHnvckBCe3OjeR?= NUjYSIpPPSEQvF2= NXTPem9KOjRiaB?= M{\5Umlv\HWldHnvckBw\iCpcnHueYxw[3m2aXOg[Iln\mW{ZX70bYF1cW:w MYixPFM5OTJ|OB?=
U937 NXzV[3BRU2mwYYPlJGF{e2G7 NWTWe2RJPSEQvF2= M3e2bFI1KGh? NYHHelhqUW6qaXLpeIlwdiCxZjDoeY1idiCKRFHDNS=> MnX5NVg{QDF{M{i=
U937 M{DT[2tqdmG|ZTDBd5NigQ>? NX;TbldDPSEQvF2= Ml7VNlQhcA>? M{fXT2lvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{S= MlvTNVg{QDF{M{i=
HEK-TE M3fId2Z2dmO2aX;uJGF{e2G7 M{i3XFUh|ryP NF[yWWQ3cA>? Mor3SG1UVw>? NIfmfpBKdmO{ZXHz[UBqdiCqaYP0c45mKEh|IHHj[ZR6dGG2aX;u MXexPFQ{PDF2NB?=
HPDE6c7 NEnKNm5EgXSxdH;4bYMhSXO|YYm= NIfqcW82OCEQvF2= MYm3NkBp NGjnZmJFVVOR NX7hcm1HUUN3ME2xMlMh|ryP NGTsWpMyQDR7NES2Ny=>
Human microvascular epithelial cell M2fldWN6fG:2b4jpZ{BCe3OjeR?= NILoS5M2OCEQvF2= MmH1O|IhcA>? MlOwSG1UVw>? M4HWSWlEPTB;MT6zJO69VQ>? MkDMNVg1QTR2NkO=
Hup T3 M3\MS2N6fG:2b4jpZ{BCe3OjeR?= MVG1NEDPxE1? MV23Nog> MnTzSG1UVw>? M1jke2lEPTB;MD64JO69VQ>? NUm5S5hLOTh2OUS0OlM>
Mia Paca2 M4PQW2N6fG:2b4jpZ{BCe3OjeR?= M3rDZlUxKM7:TR?= NGXGUZo4Omh? NFXINlBFVVOR MYTJR|UxRTFwMTFOwG0> M4fpVVE5PDl2NE[z
Panc 04.03 NHTRZ2hEgXSxdH;4bYMhSXO|YYm= MmrROVAh|ryP NELiZ5c4Omh? NXXyWmlwTE2VTx?= NGPTW4VKSzVyPUGuNkDPxE1? MXexPFQ6PDR4Mx?=
SU 86.86 NV3D[po2S3m2b4TvfIlkKEG|c3H5 M2DvdlUxKM7:TR?= NX:2UWZzPzKq M1vjNWROW09? MW\JR|UxRTFwMzFOwG0> M4DsOFE5PDl2NE[z
HEK293 M4LKN2tqdmG|ZTDBd5NigQ>? NUHyRnprOyCq NUDqW5R{UW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBJTEGFNjDlfJBz\XO|aX;uJJdqfGhiSVO1NEBw\iByLkCxPUDPxE1? NFexWnUyQDV3OE[2PS=>
HeLa M3KwbmtqdmG|ZTDBd5NigQ>? MV2yJIg> MXvJcohq[mm2aX;uJI9nKG63Y3zlZZIhUESDQzD3bZRpKEmFNUCgc4YhOC5yOEOg{txO MX6xPFU2QDZ4OR?=
RAW264.7 NGTMO2JHfW6ldHnvckBCe3OjeR?= MWSyJO69VQ>? MVqzMlUhcA>? M1zTXGROW09? M13TXGFvfGmvYXzhdolidCCjY4Tpeol1gSCjZ3HpcpN1KFCuYYPtc4RqfW1iZnHsZ4lx[XK3bTDpcoZm[3SnZDD3bZRpKEmFNUCgc4YhOC5zMTFOwG0> M3y3VVE5PjR2OU[5
NB4 M{TXPVQ5cA>? M{LRXWROW09? MWTJR|UxRTBwNjFOwG0> NULuPVMzOTh5MkOzOFk>
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CAL27 M3\obmN6fG:2b4jpZ{BCe3OjeR?= MnywO|IhcA>? M3XRcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFMvOiEQvF2= MlOyNlExQDB4Mkm=
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Sf21 MnTvT4lv[XOnIFHzd4F6 MWizJIg> Mm\iTY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= NXOxOWV6OjFyOEC2Nlk>
SKBR3 NFK2[o5EgXSxdH;4bYMhSXO|YYm= Mo[0O|IhcA>? MorlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tDWjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk43KM7:TR?= NH7zcFkzOTB6ME[yPS=>
SKOV3 M4XxfmN6fG:2b4jpZ{BCe3OjeR?= MVS3NkBp NUiwTFdxS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NGqwW5UzOTB6ME[yPS=>
COR-L23 NX\QbJhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj1[olEOTBizszN NX\CUG1rPzJiaB?= MVLEUXNQ NGfieZhIUTVyPUGuNUDPxE1? NXLaRWFrOjFyOEC2OFc>
DU145 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O1b|ExKM7:TR?= M{PyS|czKGh? MoX1SG1UVw>? MnTQS2k2OD1zLkC1JO69VQ>? MonyNlExQDB4NEe=
LoVo M3WxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCxZ4RiOTBizszN NF\4ZoQ4OiCq NHriNIlFVVOR MVXHTVUxRTFwNzFOwG0> NUHSV|lnOjFyOEC2OFc>
MCR5-SV2 NW\Rc3hwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvteYtXOTBizszN NI\nXIc4OiCq M4jhWGROW09? NVTHVIhkT0l3ME2yMlEh|ryP MUKyNVA5ODZ2Nx?=
HCT116 MknxT4lv[XOnIFHzd4F6 NGLUNIo{OCEQvF2= M3jVRlMxKGh? MmjuSG1UVw>? M1fKcWlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MXmyNVA5ODZ2Nx?=
HCT116 M4LEPWtqdmG|ZTDBd5NigQ>? NIjab2s{OCEQvF2= M37yOVMxKGh? NGLZWFdFVVOR NEixbVJKdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= NYjVdnlnOjFyOEC2OFc>
U937 MoDvT4lv[XOnIFHzd4F6 M{PNV|Uh|ryP NFPUTnYzPCCq M13rT2ROW09? NUCyVphlUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGlZYT5cIF1cW:wIH;mJIhqe3SxbnWgTFMh[XRiS{m= M{n6Z|IyOjl{NEmy
U937 M2G0V2tqdmG|ZTDBd5NigQ>? MkHrOUDPxE1? MXSyOEBp MYfEUXNQ M2izbGlvcGmkaYTpc44hd2ZiaHnzeI9v\SCjY3X0fYx1emGwc3\ldoF{\SCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBi[2W2eXzheIlwdiCxZjDobZN1d26nIFizJIF1KEtzOB?= NYXCbnF{OjF{OUK0PVI>
U937 NEe1c5pMcW6jc3WgRZN{[Xl? NHnObow2KM7:TR?= Ml\FNlQhcA>? NFHDXldFVVOR NIP5N|dKdmirYnn0bY9vKG:oIHjpd5RwdmViYXPleJltfHKjboPm[ZJie2ViYYPz[ZN{\WRiYYOgbY5kemWjc3Wgc4YheGGwLXHj[ZR6dGG2ZXSgbIl{fG:wZTDIOEBt\X[nbB?= M4fyO|IyOjl{NEmy
U937 NEP2cYVMcW6jc3WgRZN{[Xl? NEPSNpA2KM7:TR?= NF3RPIYyPSCvaX6= MVrEUXNQ Mn3pTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> M3nGe|IyOjl{NEmy
A2780 NV25e2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7LPVYhcA>? NHy4eINFVVOR NUnSOYtGUUN3ME2xMlYzKM7:TR?= NFOwS2MzOTZ|NESzNC=>
COLO205 NFTHUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TYT|k3KGh? NEXvdVBFVVOR M1\TUmlEPTB;Mj6xNkDPxE1? M2XLWVIyPjN2NEOw
Hep3B M2\TNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrjV5I1QCCq MYfEUXNQ M4jic2dKPTB;MT6yNUDPxE1? M2TwTlIyPzF{MUS2
GM11272 MWLGeY5kfGmxbjDBd5NigQ>? NH64XnMyODBibl2= MVu3NkBp NGnsZnRFVVOR M2fNZnJm[WO2aY\heIlwdiCxZjDN[WNxOiCvdYThcpQh\XiycnXzd4lwdiCjdDCxNEB1dyBzMECgcm0> NXiyVJppOjF6NEC3NVY>
CFBE41o NEDIcoRMcW6jc3WgRZN{[Xl? NE\pbIY2KM7:TR?= M3j1fmROW09? MkD2SI94diC{ZXf1cIF1cW:wIH;mJGhFSUN5IHH0JFAvOiC2bzC1JJVO NYDNRWFJOjF7OES5OVg>
CFBE41o NV21cYRrTnWwY4Tpc44hSXO|YYm= MX6xJO69VQ>? NXLHb5BvOjRiaB?= MVHEUXNQ Ml\tVoV{fG:{YYTpc44hd2ZiQ1\UVkBl\Wy2YV[1NFghdXW2YX70JJRz[W[oaXPrbY5oKHSxIHPlcIwhe3W{ZnHj[UBieyCpbInjc4Zwem2| NV3TSYxOOjF7OES5OVg>
DU145 M2T6SGtqdmG|ZTDBd5NigQ>? MoDBNk42KM7:TR?= NIW5O3QzPCCq NITNNGtFVVOR MX3Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhfXC{ZXf1cIF1cW:wIH;mJJAzOXejZkGgdJJwfGWrbjDlfJBz\XO|aX;u MmXKNlIzPjBzNk[=
DU145 MX7LbY5ie2ViQYPzZZk> MXW1JO69VQ>? NXjNU5luOjRiaB?= NGSzNFVFVVOR Mm\NTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDRiYXPleJlt[XSrb36= MXWyNlI3ODF4Nh?=
DU145 MVLLbY5ie2ViQYPzZZk> Mk\6OUDPxE1? NXfZWpVZOjRiaB?= M1OzUWROW09? M2ryVWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCqaYP0c45mKEh|IHj5dIVz[WOndInsZZRqd25? MX6yNlI3ODF4Nh?=
786-0 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7kR|F{Pi5{IN88US=> MlXkO|IhcA>? M4XwTmROW09? M{Th[WdKPTB;Mz6yJO69VQ>? MU[yNlQ{PTZ4OR?=
A498 NH3BPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXG2MlIh|ryP MVK3NkBp NY\kO4dtTE2VTx?= NWDVZYlmT0l3ME2xMlYh|ryP M3TISVIzPDN3Nk[5
A549/ATCC MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTWWI44Pi5{IN88US=> M1;NSlczKGh? NY\NbVVWTE2VTx?= NIrmUGdIUTVyPUGuOkDPxE1? MViyNlQ{PTZ4OR?=
ACHN M3XBfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LnZ|YvOiEQvF2= M2nOSFczKGh? NIjFR4dFVVOR MYPHTVUxRTFwMzFOwG0> MVuyNlQ{PTZ4OR?=
BT549 NWf2Wm1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TORlYvOiEQvF2= NETNepM4OiCq NEL6UYVFVVOR MVHHTVUxRTFwMzFOwG0> NFqxcnIzOjR|NU[2PS=>
EKVX NHe5dG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVS2MlIh|ryP M3zpelczKGh? M3nzSmROW09? NFTzWmdIUTVyPUGuN{DPxE1? M{XaNlIzPDN3Nk[5
HCT15 NIf1RnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\YSVYvOiEQvF2= NIj5S|I4OiCq Mo\aSG1UVw>? NV[zcIJ5T0l3ME2yMlUh|ryP MkfyNlI1OzV4Nkm=
HOP92 NVXTWFQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jyXFYvOiEQvF2= MWe3NkBp M2TtTmROW09? NV74[YpST0l3ME20JO69VQ>? NX\2THNDOjJ2M{W2Olk>
IGROV1 M33wU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGwOk4zKM7:TR?= M{e5NlczKGh? NWnCVZdRTE2VTx?= NULHfY4xT0l3ME2xMlMh|ryP M2XGR|IzPDN3Nk[5
LOXIMVI M1PMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWq2MlIh|ryP NWXHenpKPzJiaB?= NUD0dnE{TE2VTx?= NIe2clhIUTVyPUGg{txO NV\EZXY2OjJ2M{W2Olk>
M14 MlH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS2[G9jPi5{IN88US=> M4DIVFczKGh? NY[zdWl6TE2VTx?= NGjC[|BIUTVyPUGuN{DPxE1? MX6yNlQ{PTZ4OR?=
MALME-3M MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[2MlIh|ryP M33tUFczKGh? MlLXSG1UVw>? M1ruT2dKPTB;MD6zNkDPxE1? MVyyNlQ{PTZ4OR?=
MCF10A MmHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPXVJFVPi5{IN88US=> MVG0PEBp M{PqWGROW09? MmnPS2k2OD17Lk[g{txO M2PwPFIzPDN3Nk[5
MDA-MB-435 NUX2dIJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDMZ3NlPi5{IN88US=> M1rt[FczKGh? NG\Lc29FVVOR MVjHTVUxRTBwNTFOwG0> NVP0NZJ6OjJ2M{W2Olk>
MDA-MB-468 MlzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV62MlIh|ryP M4XQZlczKGh? MkC2SG1UVw>? MWXHTVUxRTBwNkOg{txO MUOyNlQ{PTZ4OR?=
MOLT4 NFT4UJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki2Ok4zKM7:TR?= M2DjRlczKGh? NWTVdGVFTE2VTx?= NUDTbmNJT0l3ME2wMlQh|ryP MVSyNlQ{PTZ4OR?=
NCI-ADR-RES M4LFe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT6[lJRPi5{IN88US=> Mn3UO|IhcA>? MYrEUXNQ NEjLNY1IUTVyPUCuNVYh|ryP M3LNTVIzPDN3Nk[5
NCI-H23 NVXsUVR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\QVFk3NjJizszN MUK3NkBp M4\I[WROW09? M3\2d2dKPTB;MTFOwG0> NYXK[|d2OjJ2M{W2Olk>
NCI-H322M MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LRdFYvOiEQvF2= NYnBNVNEPzJiaB?= MnzMSG1UVw>? NX7oRYVHT0l3ME2wMlc6KM7:TR?= NIPUUWszOjR|NU[2PS=>
NCI-H460 NX:xOFZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3kOk4zKM7:TR?= MWK3NkBp NYDqV4JoTE2VTx?= MXvHTVUxRTBwN{mg{txO NW\TXmh5OjJ2M{W2Olk>
NCI-H522 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSzOk4zKM7:TR?= NYeyeWdJPzJiaB?= MWHEUXNQ NIr1eWlIUTVyPUCuOUDPxE1? NYfwdlVHOjJ2M{W2Olk>
OVCAR3 NUPWd4lTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH5d4Q3NjJizszN M3mxOVczKGh? NFv4OJFFVVOR NIfHN49IUTVyPUGuN{DPxE1? NIPETZYzOjR|NU[2PS=>
OVCAR4 NGrmNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO5U5o3NjJizszN NHvCfWc4OiCq NVz1PZVETE2VTx?= M1vmTGdKPTB;NDFOwG0> M1HKZlIzPDN3Nk[5
OVCAR5 M{XKeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfY[ZV7Pi5{IN88US=> MUi3NkBp NHq5N|hFVVOR MXXHTVUxRTBwN{mg{txO MmTVNlI1OzV4Nkm=
OVCAR8 MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[1eplVPi5{IN88US=> M1\uOFczKGh? MkTQSG1UVw>? NW\S[mNOT0l3ME2wMlUh|ryP M2fOfVIzPDN3Nk[5
RXF393 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17ae|YvOiEQvF2= MWW3NkBp MUTEUXNQ MXLHTVUxRTFwMzFOwG0> Ml7yNlI1OzV4Nkm=
SF268 M1fGXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[2W|g3NjJizszN MYi3NkBp MUHEUXNQ MXjHTVUxRTFwNjFOwG0> NIXPbVgzOjR|NU[2PS=>
SF295 M1foNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni4Ok4zKM7:TR?= Ml7RO|IhcA>? MXPEUXNQ M3zwfGdKPTB;MT62JO69VQ>? NEjkcWQzOjR|NU[2PS=>
SF539 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fKT|YvOiEQvF2= MXe3NkBp Mmm1SG1UVw>? NIPoOGFIUTVyPUKg{txO NYTZS3BQOjJ2M{W2Olk>
SK-MEL-2 MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWK2MlIh|ryP NH;JOnQ4OiCq M3XCS2ROW09? MonkS2k2OD1zLkOg{txO NFTi[GgzOjR|NU[2PS=>
SK-MEL-28 MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHXc3NmPi5{IN88US=> MVu3NkBp MVLEUXNQ NWrEOlhsT0l3ME2xJO69VQ>? MVOyNlQ{PTZ4OR?=
SK-MEL-5 NIfS[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnibGs3NjJizszN NWfHcFRNPzJiaB?= Mn7qSG1UVw>? MYrHTVUxRTBwNkOg{txO NE\DbVczOjR|NU[2PS=>
SKOV3 NEHicotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDIUGJ{Pi5{IN88US=> MYe3NkBp NXjJXXRqTE2VTx?= NVzjd|ZUT0l3ME2xJO69VQ>? M4\sVVIzPDN3Nk[5
SN12C MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLoOk4zKM7:TR?= NWLo[4tZPzJiaB?= NHPLdoRFVVOR Mn7NS2k2OD1{IN88US=> NYTyT4pTOjJ2M{W2Olk>
SNB19 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TxdlYvOiEQvF2= MYC3NkBp NWL4WYc3TE2VTx?= MkCyS2k2OD1yLk[zJO69VQ>? NGDRO2szOjR|NU[2PS=>
SNB75 Ml\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHae4VuPi5{IN88US=> M4DNNVczKGh? MlvxSG1UVw>? NVHwemRpT0l3ME2wMlc6KM7:TR?= MlrwNlI1OzV4Nkm=
SR NXvlWY1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13oR|YvOiEQvF2= MXm3NkBp MnTmSG1UVw>? MmLQS2k2OD1yLkSg{txO NV\C[HdQOjJ2M{W2Olk>
T47D MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXheW9NPi5{IN88US=> M2nFNFczKGh? NUHieW06TE2VTx?= M1TVVGdKPTB;MD61JO69VQ>? NEfEWW4zOjR|NU[2PS=>
TK10 NVfDW|JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTXTldWPi5{IN88US=> MofJO|IhcA>? M2DVWGROW09? NXTHSWY4T0l3ME2wMlY{KM7:TR?= M4fxV|IzPDN3Nk[5
UACC257 M2C0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfaOk4zKM7:TR?= MWS3NkBp M2K3cmROW09? MmLxS2k2OD1yLkWg{txO NFyz[oYzOjR|NU[2PS=>
UACC62 NYW2R|ZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW[2MlIh|ryP NXfKOFlwPzJiaB?= MnTwSG1UVw>? MXPHTVUxRTBwNDFOwG0> NITJPYszOjR|NU[2PS=>
UO31 NIS5fnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TOelYvOiEQvF2= Mnn4O|IhcA>? MXnEUXNQ MWnHTVUxRTBwNTFOwG0> NHXRZZUzOjR|NU[2PS=>
Hep3B MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfUfpZZPDhiaB?= NI\hb29FVVOR MknQS2k2OD1yLk[5JO69VQ>? M2TaXFIzPDN7OE[z
BE(2)-C NFPKVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjVSHVyPzJiaB?= NVW2S|l4TE2VTx?= M4XqPGlEPzB;MjFOwG0> MoDhNlI6OzJ|MU[=
Bel7402 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfpR3A4OiCq NYT2RYk{TE2VTx?= NUfJN5hHT0l7ME2xO{DPxE1? MkTaNlMxPjF|N{[=
Bel7404 MlfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETsZ2E4OiCq MV;EUXNQ NXL1NpY2T0l7ME2xPEDPxE1? MUSyN|A3OTN5Nh?=
BGC823 M{TDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHiO|IhcA>? MUjEUXNQ M2HrRWdKQTB;Nz61JO69VQ>? NYryVlZXOjNyNkGzO|Y>
MGC803 NY\WZpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjyPYhjPzJiaB?= M2HNSWROW09? MWrHTVkxRTFyLkig{txO M4\1NVI{ODZzM{e2
SGC7901 NXviOHFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXZNXU4OiCq MnLtSG1UVw>? Mmn4S2k6OD17LkSg{txO NYrUeoxmOjNyNkGzO|Y>
SKHEP1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHhUpFnPzJiaB?= MkTrSG1UVw>? NVyxV2Y2T0l7ME2xO{DPxE1? MnH5NlMxPjF|N{[=
SMMC7721 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDi[IhiPzJiaB?= NETM[m5FVVOR NFOxSIxIUTlyPUKwJO69VQ>? NVfwc4VKOjNyNkGzO|Y>
NUGC3 NYqxO5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjFeXoyOCEQvF2= MXjHTV0zNjl2IN88US=> MkDVNlMyPjN|M{K=
A2780 CisR MWLLbY5ie2ViQYPzZZk> M4TKbVE5KGh? NXLH[GFLUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= M2TLO|I{OjV{NkCz
CAL27 sens NGjrUGdMcW6jc3WgRZN{[Xl? NHHyNYQyQCCq NWTQbpJvUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlM3KM7:TR?= M3rSSVI{OjV{NkCz
CAL27 CisR M{nIUWtqdmG|ZTDBd5NigQ>? NFH2cHMyQCCq NH\6c3lKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP NI[4cnUzOzJ3Mk[wNy=>
KYSE-510 CisR NELob3VMcW6jc3WgRZN{[Xl? MUKxPEBp NV\ie|hjUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlU6KM7:TR?= NHHWd4ozOzJ3Mk[wNy=>
KYSE-510 sens MXPLbY5ie2ViQYPzZZk> M3T2[FE5KGh? M2T6VWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD63JO69VQ>? NVn6U2FvOjN{NUK2NFM>
MDA-MB-231 sens NGHVNWlMcW6jc3WgRZN{[Xl? NH;TSGcyQCCq M3n1RmlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD62NUDPxE1? M3m4T|I{OjV{NkCz
MDA-MB-231 CisR MVHLbY5ie2ViQYPzZZk> NWrWSmxSOThiaB?= NGLMNFhKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOlEh|ryP M2jpT|I{OjV{NkCz
ES2 NFLBUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLlZ4RXPDhiaB?= NIq5cZBFVVOR MnnLTWM2OD1zMj63JO69VQ>? NUnOdXBqOjN2OUO0OFk>
MDA-MB-231 MYfLbY5ie2ViQYPzZZk> M2mz[FExKM7:TR?= MUGzNEBucW5? NFrBcYNFVVOR NGSwRYNKdmirYnn0bY9vKG:oIFjERWMz[Q>? MYOyN|Q6OzR2OR?=
MDA-MB-231 NV3kUWIyU2mwYYPlJGF{e2G7 NIPXZZQyKM7:TR?= NHT0[ZgzPCCq NH3GTWVFVVOR NIfnNldKdmirYnn0bY9vKG:oIFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu MnPkNlM1QTN2NEm=
HS68 NYnzb|k2S3m2b4TvfIlkKEG|c3H5 NULMSnF{OTBizszN NFnPS5A4OiCq MYXEUXNQ MU\JR|UxRTRwNjFOwG0> MkXZNlM2PzB3NEK=
MEF MlKyR5l1d3SxeHnjJGF{e2G7 M{\VNlExKM7:TR?= M2PseFczKGh? NUew[nZNTE2VTx?= M2f0TWlEPTB;ND60JO69VQ>? MYCyN|U4ODV2Mh?=
BGC823 NFflS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPVSG1UVw>? Mmq4S2k2OD1|LkC5JO69VQ>? M4j5VVI{PjBzN{C2
High5 Mn;yT4lv[XOnIFHzd4F6 MorPNlQhcA>? NXjLOlRwUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDISGFEPiC5aYToJGlEPTBib3[gNE4xQSEQvF2= MkH1NlM3ODJ3MkO=
High5 MmfRT4lv[XOnIFHzd4F6 NGPmWoszPCCq MnrnTY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCKRFHDNUB4cXSqIFnDOVAhd2ZiMD6xNkDPxE1? M3fFZ|I{PjB{NUKz
High5 NX[xZ2lDU2mwYYPlJGF{e2G7 MYWyOEBp NFnIWJRKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWM{KHerdHigTWM2OCCxZjCwMlE4KM7:TR?= NH3pWnQzOzZyMkWyNy=>
A549 NV;nWoJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\hd4NXTE2VTx?= NGXNe5FKSzVyPUGuNFc6KM7:TR?= Mn\KNlM3PDR{MUC=
HCT116 NWfuSXc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTEUXNQ NFHUVG5KSzVyPUCuO|U4KM7:TR?= MX[yN|Y1PDJzMB?=
K562 NXvjU2dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rjRmROW09? MY\JR|UxRTBwNkS1JO69VQ>? MUOyN|Y1PDJzMB?=
GBC-SD NUe5XIZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWyWXY2KM7:TR?= MlPKO|IhcA>? MYTEUXNQ NG\vdHVKSzVyPUG0Mlgh|ryP NYrVelRqOjN5MEeyOlA>
HGC27 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi4fnl1PSEQvF2= M4Xrd|czKGh? M{LQc2ROW09? NWi4fHBUUUN3ME21MlQh|ryP NXHRbpVoOjN5MEeyOlA>
HL60 NXzzNHM6U2mwYYPlJGF{e2G7 MWC1JO69VQ>? MmTCNlQhcA>? NFXuXnFFVVOR MYPJcohq[mm2aX;uJI9nKEiGQVO= NGf0eVczOzdyN{K2NC=>
Vero MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LUc|czKGh? NVjp[2QyTE2VTx?= MV\JR|UxRTBwOTFOwG0> MofFNlM4QDZ2NUK=
NCI60 M4\yfGN6fG:2b4jpZ{BCe3OjeR?= NIDpVlQ1QCCq M3qxR2ROW09? MV7HTV0xNjV|IN88US=> MmPSNlQxOTV|Mke=
SW620 MXXDfZRwfG:6aXOgRZN{[Xl? MnfZOFghcA>? M3TvTGROW09? M1exZ2dKRTBwNUSg{txO M3TYVlI1ODF3M{K3
U251 NGD3dHBEgXSxdH;4bYMhSXO|YYm= MWK0PEBp MmXHSG1UVw>? NVntRVY5T0l;MT61N{DPxE1? M{DoTlI1ODF3M{K3
KM12 NH64copEgXSxdH;4bYMhSXO|YYm= M3POd|Q5KGh? NV\5VVJqTE2VTx?= MVzHTV0yNjh6IN88US=> NGn5NFgzPDBzNUOyOy=>
Hs578T NHjlfYVEgXSxdH;4bYMhSXO|YYm= MYi0PEBp NGXYWXlFVVOR NYXqfWQxT0l;ND64N{DPxE1? M1L5WFI1ODF3M{K3
MDA-MB-231 M4\lOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOzXWRpPDhiaB?= MXrJR|UxRTBwMU[g{txO MlW4NlQxQTVyMU[=
MCF7 NFXwSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWi0PEBp NGrFPIhIUT1yLkS1JO69VQ>? MoLjNlQyOTl3NUW=
MDA-MB-435 NWHPWHBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jhXlQ5KGh? NVjqbVA2T0l;MD64PEDPxE1? NXv3PJNyOjRzMUm1OVU>
AsPC1 NXzEOI43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TTU|MxKM7:TR?= MVi0PEBp M17nb2ROW09? MVXJR|UxRTNwNk[g{txO NXm4V4x6OjRzOEWzO|g>
Jurkat E6.1 NWXiS|g5U2mwYYPlJGF{e2G7 Mli4NkBp Mmj2SG1UVw>? NFvZeJNKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= Mor3NlQzPjF6NkK=
KG1 NIfifXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWW0PEBp MUTJR|UxRTFwMUWg{txO MYSyOFUzPTByMx?=
HEL MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKwO4M1QCCq M{H1O2ROW09? NXzZZYFpUUN3ME2wMlQ6KM7:TR?= Mom3NlQ3QTRyNUW=
HSC3 MoDmR5l1d3SxeHnjJGF{e2G7 MkTMNVIhcA>? NIroeoZFVVOR MYDJR|UxRTBwN{Gg{txO MkDDNlQ4PjZ3NkC=
HT-29 M37VXWN6fG:2b4jpZ{BCe3OjeR?= M1PObVEzKGh? NHvHcGtFVVOR NFnoZo1KSzVyPUCuO|Ih|ryP NI\4VWYzPDd4NkW2NC=>
KB MmjmR5l1d3SxeHnjJGF{e2G7 Mo\4NVIhcA>? NF:zSoFFVVOR Ml;xTWM2OD1yLke1JO69VQ>? M3zNZlI1PzZ4NU[w
H460 NHvhS2dEgXSxdH;4bYMhSXO|YYm= Mkf4NVIhcA>? MVPEUXNQ MWnJR|UxRTBwOEKg{txO NF;BSI8zPDd4NkW2NC=>
MONE1 NGS5cnlEgXSxdH;4bYMhSXO|YYm= M4T2OFEzKGh? MX;EUXNQ MlrzTWM2OD1zLkG4JO69VQ>? MYSyOFc3PjV4MB?=
MKN45 NUS3T41{S3m2b4TvfIlkKEG|c3H5 NH7Bb4QyOiCq M36xfGROW09? NFPFW3RKSzVyPUGuNlUh|ryP NVzaWY9GOjR5Nk[1OlA>
TSGH NFPrUG5EgXSxdH;4bYMhSXO|YYm= MmK0NVIhcA>? NXPGbW5XTE2VTx?= NYHkZ2FsUUN3ME2yMlA6KM7:TR?= MVmyOFc3PjV4MB?=
HL60 NGnTVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnEfnRNPzJiaB?= M4fqNGROW09? MVvHTVUxRTBwOUOg{txO M4PVR|I1QTByNUCw
HEK293 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILSOnE4OiCq MlPPSG1UVw>? Mon4S2k2OD1zMzFOwG0> NE\VdnkzPDlyMEWwNC=>
Jurkat NWf5VFhTS3m2b4TvfIlkKEG|c3H5 MkPZNVAxKM7:TR?= NF3KTHc4OiCq MnO1S2k2OD1yLkmg{txO MXSyOFkxODd2Mx?=
GM15850 M{jobmtqdmG|ZTDBd5NigQ>? NHnzXWIzNjVizszN M{DRS|k3KGh? NES5R21FVVOR MkHH[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFE1KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l Mof0NVY6OjF|Nke=
GM15850 MXzLbY5ie2ViQYPzZZk> MmnoNk42KM7:TR?= MmTjPVYhcA>? NXS0R3RvTE2VTx?= MVjkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgOUBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= NFfhc5MyPjl{MUO2Oy=>
GM15850 Ml3lT4lv[XOnIFHzd4F6 M33ZWlIvPSEQvF2= MmDwPVYhcA>? MVLEUXNQ MWfkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= M4WzbVE3QTJzM{[3
GM15850 NWf0NZNLU2mwYYPlJGF{e2G7 MUiyMlUh|ryP MYW5OkBp M4\GemROW09? M{nFcoRw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UA6KGGlZYT5cIF1cW:wIH;mJGZZViCpZX7l NWHhWGJOOTZ7MkGzOlc>
GM15850 NEPK[JpMcW6jc3WgRZN{[Xl? M4TFN|IvPSEQvF2= NGHFTG86PiCq NX20VoFwTE2VTx?= MXjkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgPEBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M{C1XlE3QTJzM{[3
GM15850 MW\LbY5ie2ViQYPzZZk> M3TFUlIvPSEQvF2= M{HkRlk3KGh? NHvOd5dFVVOR NHHGcIhld2W|IH7veEBqdmirYnn0JGhFSUNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcGm|dH;u[UBJPCCueYPpcoUhOTZiYXPleJlt[XSrb36gc4YhTliQIHflcoU> MXmxOlkzOTN4Nx?=
GM15850 MV;GeY5kfGmxbjDBd5NigQ>? NWLqfldsPSEQvF2= MoroNVIhcA>? NVHPeXE2TE2VTx?= MkXObIF{KG6xIHXm[oVkfCCxbjDGXG4hdVKQQTDlfJBz\XO|aX;u NU[3[pZnOTZ7MkGzOlc>
U937 MWXLbY5ie2ViQYPzZZk> M2DWOVUh|ryP M4TZOFI1KGh? NGi5W2FFVVOR MVvoZZMhdm9iZX\m[YN1KG:wIHHsdIhiKHS3YoXsbY4h[WOndInsZZRqd25? NGjD[VgyPzR2N{e1NC=>
U937 NWLQTmxVU2mwYYPlJGF{e2G7 MkSxNUDPxE1? M1jBO|I1KGh? NH;3WWhFVVOR NHPZOXVp[XNibn:g[YZn\WO2IH;uJIFteGijIIT1ZpVtcW5iYXPleJlt[XSrb36= MnK3NVc1PDd5NUC=
PANC1 MUTGeY5kfGmxbjDBd5NigQ>? M3HycFEh|ryP NXjheI54OjRiaB?= MYjkc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= NYj0WIxVOTd3OEi3OFQ>
PANC1 NFXBRpZHfW6ldHnvckBCe3OjeR?= M37zflEh|ryP NXWxbJd1PDhiIHi= MVHkc4V{KG6xdDDpcoNz\WG|ZTDpckBxOjetaYCxJIdmdmViZYjwdoV{e2mxbh?= M1niOVE4PTh6N{S0
Caco-2 NFLyeo9HfW6ldHnvckBCe3OjeR?= MVi1JO69VQ>? NWXnWoJtOjRiaB?= NGD1ZZVFVVOR MVnkc4V{KG6xdDDpcoR2[2ViUEKxW2FHOSCpZX7lJIV5eHKnc4Ppc44> MnHZNlAyPDN6NEC=
SCC4 NVHQRYlbTnWwY4Tpc44hSXO|YYm= M1eyeFEh|ryP NEnxSm4yOCCvaX6= NVnCe5B[TE2VTx?= MYroZZMhdm9iYXfvcol{fCCjY4Tpeol1gSCjdDDWSHIh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJGN[WDJ2IHflcoUh\XiycnXzd4lwdg>? NUm2SYZ[OjB2NUKyNlU>
A549 M2Dnd2Z2dmO2aX;uJGF{e2G7 MlXEOUDPxE1? MUizJIg> M{DJUmROW09? MnfJ[I9meyCwb4SgbY5lfWOnIHH1eI9xcGGpeTDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCOQ{PJTS=> MVqyNFg2PTJyOB?=
HCT116 MXvLbY5ie2ViQYPzZZk> NGC5XmwxNjNizszN MVizNEBp NETaUW5FVVOR MkC5[I9meyCwb4SgbY5pcWKrdDDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJO0t7IHHj[ZR6dGG2aX;u NF7Ncm0zOTB6ME[0Oy=>
HepG2 NGHs[GxHfW6ldHnvckBCe3OjeR?= NV\zV|FuOTBizszN NWjyeJVsOjRiaB?= NXLKR5pXTE2VTx?= NIDIbVRld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KGi7cHXyZYNmfHmuYYTpc44hd2ZicEWz MUCyNVU1QDV6Mh?=
GM11272 NY\0N4c{TnWwY4Tpc44hSXO|YYm= M2faVlAvOSEQvF2= NUTyR2NDPzJiaB?= Ml:wSG1UVw>? Mkjl[I9meyCwb4SgdoVi[3SrdnH0[UBO\UOyMjDteZRidnRiZYjwdoV{e2mxbh?= M3OzXVIyQDRyN{G2
MDA-MB-231 M2KydmtqdmG|ZTDBd5NigQ>? NGHG[GwyOCEQvF2= MYO1JI1qdg>? M2HGc2ROW09? Ml\i[I9meyCwb4SgbY5pcWKrdDDISGFEOmF? NE\TcYkzOzR7M{S0PS=>
MDA-MB-231 MkTCT4lv[XOnIFHzd4F6 Ml:4NUDPxE1? MXKyOEBp M4PodGROW09? MXfkc4V{KG6xdDDpcohq[mm2IFjERWM3KGG|c3Xzd4VlKGG|IHHj[ZR6dGG2aX;uJIxmfmWuczDv[kB1fWK3bHnu MnLhNlM1QTN2NEm=
K562 MlXmT4lv[XOnIFHzd4F6 NGO2flRld2W|IH7veEBqdmirYnn0JGhFSUN? NHLLWGkzOzV7MUGxNS=>
Jurkat M3rsZWN6fG:2b4jpZ{BCe3OjeR?= MV[yNEDPxE1? MoPJO|IhcA>? NHnZdnVFVVOR M1\QUo5wKGO7dH;0c5hq[2m2eTDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvci=> NHTsPIIzPDNyNEO0PC=>
HCT116 MXTBdI9xfG:|aYOgRZN{[Xl? NIfK[ZQ{KM7:TR?= MWmyOEBp MXHEUXNQ NYLGSGxY\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDwOVMheHKxdHXpckBt\X[nbB?= NHHlb5QzPDd4NkW2NC=>
KASUMI-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV63b2lmUUN3ME25PU4yPyCwTR?= M1P5ZXNCVkeHUh?=
KARPAS-45 NYjhSoRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjoTWM2OD1zN{OuPFkhdk1? M4Sw[HNCVkeHUh?=
BHT-101 NFLkfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rT[GlEPTB;MkS0MlE5KG6P NEjHUWtUSU6JRWK=
H9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJ3NT6wOEBvVQ>? MUHTRW5ITVJ?
PA-1 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\mTWM2OD1{OE[uNlYhdk1? NH;ON5JUSU6JRWK=
NEC8 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1WwN2lEPTB;Mki5MlM5KG6P MVTTRW5ITVJ?
MHH-PREB-1 NWfGTYl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLCTWM2OD1{OUSuOVMhdk1? MoLnV2FPT0WU
NB7 NX;HVJJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvmTWM2OD1|NEWuO|Qhdk1? M3y1OnNCVkeHUh?=
A3-KAW M3HQ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTRyMD61PUBvVQ>? MUPTRW5ITVJ?
NB69 NILzc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn3e4pKSzVyPUSxNU44OSCwTR?= NEPmfoxUSU6JRWK=
EoL-1-cell NXHmWJNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTR3NEK1JI5O NH3uN|JUSU6JRWK=
CHP-212 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLNTWM2OD12NUeuOVMhdk1? MVrTRW5ITVJ?
C2BBe1 NYfOTldVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH2TWM2OD12N{KuNVkhdk1? M2\TeXNCVkeHUh?=
697 NH;u[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\ib2dYUUN3ME20O|MvPDFibl2= MV;TRW5ITVJ?
BCPAP NUPOeZhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTVyMT60NkBvVQ>? MnG2V2FPT0WU
L-363 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrrfodKSzVyPUWwN{4yKG6P MXrTRW5ITVJ?
ES8 NHPvO2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rafGlEPTB;NUKzMlU{KG6P MXPTRW5ITVJ?
BE-13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rtSmlEPTB;NUK2Mlk3KG6P MYrTRW5ITVJ?
CTB-1 NWrabGE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEOxWHFKSzVyPUWzO{46OiCwTR?= NFLifnRUSU6JRWK=
HD-MY-Z NFLuW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\IWmJKSzVyPUWzPE4yOyCwTR?= NGTHS2VUSU6JRWK=
NKM-1 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTWO2ZKSzVyPUW0OE4zPyCwTR?= M4fwWnNCVkeHUh?=
NCI-H720 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljoTWM2OD13NkCuNVghdk1? NEjrenRUSU6JRWK=
KY821 M4\BWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTV4Mz6yOUBvVQ>? M2HacnNCVkeHUh?=
OVCAR-5 MlvsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LuN2lEPTB;NUe2MlEyKG6P NEjrXZlUSU6JRWK=
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JVM-3 NVPUSZJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTye5RrUUN3ME2xMlg2PDVzIN88US=> NFO1WIhUSU6JRWK=
OS-RC-2 NEnHS5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HZSWlEPTB;MT64O|E2OSEQvF2= NH35UYxUSU6JRWK=
COLO-320-HSR NWjtWJhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPKO5lGUUN3ME2xMlg5OTl5IN88US=> NIXqS3dUSU6JRWK=
HN MlPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\ZNopKSzVyPUGuPFg4OjVizszN MYjTRW5ITVJ?
HT NUnqTW9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mwT2lEPTB;MT64PFk1PyEQvF2= M{nkSnNCVkeHUh?=
LoVo NHPobGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwOEm4NUDPxE1? NYLBTWZFW0GQR1XS
CGTH-W-1 M1T1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\oZ2lEPTB;MT64PVk1PiEQvF2= NGL6[FlUSU6JRWK=
NB6 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTFwOUGyPVgh|ryP M1nGfXNCVkeHUh?=
EW-22 MnK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfBTWM2OD1zLkmyPFg4KM7:TR?= MknLV2FPT0WU
ES6 Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPSfYFTUUN3ME2xMlk{PjNzIN88US=> Mk\NV2FPT0WU
SCC-15 NGfRdXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFwOUO4NVkh|ryP NH75eYlUSU6JRWK=
HL-60 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFwOUO5NFIh|ryP NFnWWHBUSU6JRWK=
human HOP-92 M1XtPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFwOUSwOlUh|ryP MmfwV2FPT0WU
SW626 MnjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\VPGhZUUN3ME2xMlk1QDl7IN88US=> Mo\XV2FPT0WU
HEC-1 NUTNN5JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfMdJV{UUN3ME2xMlk2OzZizszN NU[4PVF6W0GQR1XS
LB2241-RCC NGe4UoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwOUiyN|Eh|ryP NWDVdFQzW0GQR1XS
Ramos-2G6-4C10 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7KTW85UUN3ME2xMlk6PDl|IN88US=> NVzzT2JFW0GQR1XS
A101D M33h[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoH3TWM2OD1{LkKwN|A{KM7:TR?= M2HlcXNCVkeHUh?=
NCI-H446 NXm3OVR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PtRmlEPTB;Mj6wOFU6QSEQvF2= NYXnSJpsW0GQR1XS
SBC-5 M3PjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX61O2JIUUN3ME2yMlA3OTR5IN88US=> NEPONHJUSU6JRWK=
HOS MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzTbXRKSzVyPUKuNFc3PTNizszN MVzTRW5ITVJ?
K5 M4LwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfLTWM2OD1{LkC3PFEyKM7:TR?= NVzvOng2W0GQR1XS
HLE MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rD[mlEPTB;Mj6wPFUzQSEQvF2= NHvKZ5BUSU6JRWK=
HSC-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzKW4FtUUN3ME2yMlEzQDl6IN88US=> NFXpNnFUSU6JRWK=
LCLC-97TM1 NITDfYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJwMUS1PFMh|ryP NFXMWmFUSU6JRWK=
DMS-273 M4ez[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnaXlFwUUN3ME2yMlE1QDN5IN88US=> NES5OFNUSU6JRWK=
TE-8 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTJwMUW3OlUh|ryP MonBV2FPT0WU
DSH1 M4S1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fTXmlEPTB;Mj6xOlM6QCEQvF2= M36yc3NCVkeHUh?=
CAL-51 NEe4cYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j1fmlEPTB;Mj6xOlY6QSEQvF2= MWPTRW5ITVJ?
IST-SL1 NGPLN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXT1dphOUUN3ME2yMlE3QDR2IN88US=> NWfHSpZbW0GQR1XS
GCT Ml73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC0TWM2OD1{LkG3O|ch|ryP MXrTRW5ITVJ?
SW948 NIrqO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwMUi0OVYh|ryP NFfpO3hUSU6JRWK=
NOMO-1 M1KxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP1XodKSzVyPUKuNVk{OTdizszN NH7VTIFUSU6JRWK=
C8166 Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfMRWFKSzVyPUKuNlE{OzRizszN MoP2V2FPT0WU
OC-314 NHTiXVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LnR2lEPTB;Mj6yN|I2QSEQvF2= M1OyPHNCVkeHUh?=
CAL-39 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rEUGlEPTB;Mj6yN|YzPiEQvF2= MnriV2FPT0WU
MDA-MB-453 M2XUSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwMkSyO|Uh|ryP M1TzbnNCVkeHUh?=
A673 MmDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{ftNGlEPTB;Mj6yOVg3OiEQvF2= NWiyVXp1W0GQR1XS
HTC-C3 NWHaSYY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\IWmlEPTB;Mj6yOlg2KM7:TR?= NGLGZVJUSU6JRWK=
NCI-H1666 NYnufmkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7TTWM2OD1{LkK4NVEyKM7:TR?= Moq3V2FPT0WU
PSN1 M335VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHpdpZKSzVyPUKuNlg6OTNizszN MVzTRW5ITVJ?
GI-1 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrFfFM1UUN3ME2yMlMxPTR|IN88US=> MXnTRW5ITVJ?
HuH-7 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFntNW5KSzVyPUKuN|A3OzdizszN M{m2N3NCVkeHUh?=
JAR MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLjTWM2OD1{LkOxPVg4KM7:TR?= MUPTRW5ITVJ?
5637 NYDySoR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\HbnBuUUN3ME2yMlMzOTJ7IN88US=> M1XlTHNCVkeHUh?=
GB-1 M33qTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\EU5JRUUN3ME2yMlMzOzN3IN88US=> NIDmfphUSU6JRWK=
KP-N-YS NFPjdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHxXHlLUUN3ME2yMlMzPjF3IN88US=> MnPZV2FPT0WU
OAW-42 NUPXc3BST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEe1dYZKSzVyPUKuN|M1OTZizszN M1\oVnNCVkeHUh?=
8-MG-BA MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHjRoZKSzVyPUKuN|M6ODZizszN NWqzWGVQW0GQR1XS
RH-18 M{XKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HOS2lEPTB;Mj6zOVAzOiEQvF2= NEjRSHlUSU6JRWK=
NCI-H1155 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHtTWM2OD1{LkO2O|I2KM7:TR?= MoTGV2FPT0WU
NB17 NH24SW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi4[nNpUUN3ME2yMlM5OjR|IN88US=> NYjNVok{W0GQR1XS
NCI-H1437 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJwNEG4O|Mh|ryP NWH1NG5sW0GQR1XS
SN12C MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwNEOyNVQh|ryP M2rTOXNCVkeHUh?=
HSC-3 NGDJSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTJwNES1NFkh|ryP NF7aOoRUSU6JRWK=
GAMG M37kUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X6NmlEPTB;Mj60OFU3OSEQvF2= MnThV2FPT0WU
HT-1080 NGmzSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXoS21UUUN3ME2yMlQ1QDZ2IN88US=> M4nRWnNCVkeHUh?=
A549 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfnfJpDUUN3ME2yMlQ1QDl|IN88US=> NGnTVVBUSU6JRWK=
KNS-62 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHjcWM3UUN3ME2yMlQ2ODZzIN88US=> MUDTRW5ITVJ?
YKG-1 NUDD[ZZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJwNEW0N|ch|ryP MnrkV2FPT0WU
LU-134-A MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYixWVVKUUN3ME2yMlQ4ODB6IN88US=> NEPJbHZUSU6JRWK=
FADU MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DH[mlEPTB;Mj60O|E3OiEQvF2= MYLTRW5ITVJ?
TGBC11TKB MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHubWtmUUN3ME2yMlQ4OTd5IN88US=> M17nO3NCVkeHUh?=
HT-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFflOIVKSzVyPUKuOFk2OzVizszN Mn\uV2FPT0WU
NCI-H2170 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLMTWM2OD1{LkWwOVQ6KM7:TR?= MnTmV2FPT0WU
Mo-T MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwNUC5Nlch|ryP MmXGV2FPT0WU
CCRF-CEM NUe3dIlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDjdY97UUN3ME2yMlU{ODR|IN88US=> M3nmXXNCVkeHUh?=
KU-19-19 M3v3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLqOo85UUN3ME2yMlU{PTF|IN88US=> M2n1UXNCVkeHUh?=
NCI-H1048 NYfHWGJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP0TWM2OD1{LkW1NFI2KM7:TR?= NET1d21USU6JRWK=
KOSC-2 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULOW2R4UUN3ME2yMlU3ODd4IN88US=> NITsNHBUSU6JRWK=
A431 NI\xW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHlTWM2OD1{LkW2N|M2KM7:TR?= M{i3bXNCVkeHUh?=
COR-L23 NEezdW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\mTWM2OD1{LkW4OVY3KM7:TR?= MkjzV2FPT0WU
MKN28 M3LPcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;hOWlEPTB;Mj61PVA{PyEQvF2= M1zRe3NCVkeHUh?=
22RV1 NXnpR2h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfWTWM2OD1{LkW5Nlc1KM7:TR?= NXq1Z2t[W0GQR1XS
ABC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jxc2lEPTB;Mj62NFQ3KM7:TR?= MojaV2FPT0WU
NCI-H2126 Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTJwNkC5PFQh|ryP M33pTHNCVkeHUh?=
DoTc2-4510 M4jvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP5e2FQUUN3ME2yMlYzOTh3IN88US=> M4XFPHNCVkeHUh?=
SCC-4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXJepNKSzVyPUKuOlMxOTJizszN MV;TRW5ITVJ?
NCI-H661 NE\LUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\4cpVKSzVyPUKuOlQxQDVizszN M4D3b3NCVkeHUh?=
RPMI-2650 NHPadGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwNkSxOFMh|ryP NXu4e2ZuW0GQR1XS
NCI-H510A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzBcIlKSzVyPUKuOlQ1OjZizszN MYLTRW5ITVJ?
BPH-1 NEXtN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnhTWM2OD1{Lk[1PFUh|ryP MnzoV2FPT0WU
M14 Ml\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLlXlRKSzVyPUKuOlY6QTNizszN NIf0SG1USU6JRWK=
G-402 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJwN{C0OVEh|ryP NGG3Uo9USU6JRWK=
AsPC-1 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1frXGlEPTB;Mj63NVE4KM7:TR?= MYPTRW5ITVJ?
NB12 M4j1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwN{G3NUDPxE1? M3PhRnNCVkeHUh?=
SK-HEP-1 M174NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfZUVRKSzVyPUKuO|Q{QTFizszN MXHTRW5ITVJ?
U-266 M1SwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fwbmlEPTB;Mj63O|EzOSEQvF2= M1XhVXNCVkeHUh?=
AM-38 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\1R4hLUUN3ME2yMlc4OzV3IN88US=> M1n1T3NCVkeHUh?=
PC-14 M2e5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPod2MyUUN3ME2yMlgxPTFizszN M{fwT3NCVkeHUh?=
EGI-1 M3ridWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwOEG3OFMh|ryP MmrTV2FPT0WU
LS-411N NE[3cI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJwOEKzN{DPxE1? MY\TRW5ITVJ?
BFTC-905 NHSwUGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHjZZBKSzVyPUKuPFU2OjNizszN M{f1Z3NCVkeHUh?=
CaR-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\TdYlIUUN3ME2yMlg3KM7:TR?= MnnhV2FPT0WU
NCI-H292 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnmcYpmUUN3ME2yMlg3PTl4IN88US=> MlvvV2FPT0WU
8305C M1zKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDPdXJGUUN3ME2yMlg3PjR3IN88US=> MX\TRW5ITVJ?
SNU-449 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwOEmxPFIh|ryP NVnLcWxxW0GQR1XS
LCLC-103H MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO1XmJKSzVyPUKuPVA1OzhizszN NIHue|NUSU6JRWK=
SW1573 M3jsd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzoXGFoUUN3ME2yMlk3ODh{IN88US=> NXjMWm5rW0GQR1XS
MLMA NFrOeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHlWXJ4UUN3ME2yMlk3PzF5IN88US=> NGHsN|dUSU6JRWK=
NCI-H1355 NGXCNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzUWWZKSzVyPUOuNFA4QTZizszN MlfjV2FPT0WU
RMG-I MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvR[IE1UUN3ME2zMlAzPTl{IN88US=> Mn7rV2FPT0WU
BB65-RCC NVvJ[JZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;vZ4RJUUN3ME2zMlA{OzF2IN88US=> NUjucGlFW0GQR1XS
PC-3 M4PGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\PUWlEPTB;Mz6wN|g4PCEQvF2= NYLGeWVtW0GQR1XS
SF268 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf6TWM2OD1|LkC0OVI{KM7:TR?= NWr1bo97W0GQR1XS
NCI-H810 M3;zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwMES4NlMh|ryP MX7TRW5ITVJ?
MEG-01 MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjhTWM2OD1|LkC2NVY1KM7:TR?= NFXjNGZUSU6JRWK=
SW13 MlTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXsNHZ1UUN3ME2zMlA4QDR5IN88US=> NGDLbHlUSU6JRWK=
RH-1 M3nkTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz0e4toUUN3ME2zMlExOjd6IN88US=> M4XCeXNCVkeHUh?=
GT3TKB NYnoTIxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfD[JBKSzVyPUOuNVEzQDNizszN MWPTRW5ITVJ?
TK10 NI\WdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTNwMUO3NlQh|ryP MXnTRW5ITVJ?
T-24 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnkT3ZKSzVyPUOuNVUxPyEQvF2= MojhV2FPT0WU
A498 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TIUGlEPTB;Mz6yNFg4OSEQvF2= NVXGfIh5W0GQR1XS
GR-ST MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLGcJBHUUN3ME2zMlIzOTN7IN88US=> M4\ONHNCVkeHUh?=
LB2518-MEL M3X4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{[4TmlEPTB;Mz6yNlM6QCEQvF2= M3j1cHNCVkeHUh?=
T47D MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTNwMkO2Nlch|ryP M4HSXHNCVkeHUh?=
NCI-H1651 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTNwMkS2OFQh|ryP NIO2ZolUSU6JRWK=
EC-GI-10 Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvWeYJKSzVyPUOuNlYyPTNizszN NFq2W4RUSU6JRWK=
HT-29 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHtTWM2OD1|LkK2OlE1KM7:TR?= MofqV2FPT0WU
GI-ME-N M{mwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTNwMkm1NVEh|ryP MXrTRW5ITVJ?
SW756 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX0TWM2OD1|LkK5OlI6KM7:TR?= NULKcYduW0GQR1XS
RKO M2H3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOwbHhkUUN3ME2zMlMxPzV5IN88US=> NFWzdldUSU6JRWK=
NCI-H1563 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\XTWM2OD1|LkOzNFE5KM7:TR?= NI\LWpdUSU6JRWK=
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NCI-H596 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXrTWM2OD1{Mz65NFU2KM7:TR?= MVXTRW5ITVJ?
MZ1-PC NX3W[G9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTJ2Lk[3OVkh|ryP NHHQT5VUSU6JRWK=
SW1417 NYGzWml5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJ3LkK0PVgh|ryP MV3TRW5ITVJ?
NCI-H82 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTJ4LkSyPFgh|ryP MYfTRW5ITVJ?
COLO-678 NHTLS3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJ5LkS5NVkh|ryP MoHkV2FPT0WU
KURAMOCHI M3Hsb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS4TWM2OD1{OD6xNlYh|ryP NIr2XYpUSU6JRWK=
NCI-H1650 NFLQfJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXuTWM2OD1|MD6xPVI1KM7:TR?= NF;lcHdUSU6JRWK=
HCC1954 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNzLkO2OlYh|ryP MlXTV2FPT0WU
GAK NIr1ZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnGfG5VUUN3ME2zNk4zPjF4IN88US=> MnrtV2FPT0WU
YAPC M3rTU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTN|Lke2OFgh|ryP NGruT2pUSU6JRWK=
NCI-H2228 NUTQOnh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTN2LkO2NFUh|ryP Mm\1V2FPT0WU
VMRC-RCZ M{DYe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDkbJRKSzVyPUO2MlMxOjJizszN NFX0S4tUSU6JRWK=
NMC-G1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrZUotKSzVyPUO3MlA2OjlizszN NVPifZdoW0GQR1XS
D-336MG M1rSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjCTWM2OD12MT64OFQzKM7:TR?= MmK3V2FPT0WU
UACC-62 NFeyZoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTR{LkW1NFUh|ryP M{T6THNCVkeHUh?=
C-33-A NXrJNHpOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHvTHFHUUN3ME20OU4{OjV4IN88US=> M2\yTHNCVkeHUh?=
HCC1937 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrwPIZ4UUN3ME20O{4yQTV6IN88US=> NVHPbnJGW0GQR1XS
HDLM-2 M{TIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLRfFM4UUN3ME20O{4zOjh5IN88US=> M1:0e3NCVkeHUh?=
NCI-H727 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTR5LkK0OVEh|ryP MnjsV2FPT0WU
NY MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTR7LkO5NFgh|ryP MWnTRW5ITVJ?
NCI-H2291 NVLTOWk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DYWmlEPTB;NEmuPFMxOSEQvF2= NYPOT|dNW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Ac-Histone H4 / Ac-Histone H3; 

PubMed: 21598070     


D54 and U87 glioma cells were treated with lower concentrations (1-3 µM) of vorinostat. The effects on histone acetylation was assessed by immunoblotting. 

phospho-CDK1; 

PubMed: 21598070     


Changes in level of inhibitory phosphorylation of cdk1 after treatment with vorinostat was determined at 24 and 48 h (using a Tyr-15 residue phospho-specific antibody) along with total cdk1 as loading control. 

phospho-Cdc25c / Cdc25c; 

PubMed: 21598070     


Time course of changes in phospho-cdc25c levels after exposure to vorinostat (5 µM).

Cyclin B1; 

PubMed: 21598070     


Cyclin B1 levels were determined in D54 and U87 cells after treatment with various doses of vorinostat at 24 and 48 h.

c-Myc / c-Raf / Akt / Cyclin D1 / CDK4; 

PubMed: 19440035     


Cell lysates from JeKo-1 and Mo2058 cells exposed to vorinostat  were immunoblotted for c-Myc, c-Raf, AKT, cyclin D1, CDK4 and acetylated histone H3. The levels of β-actin served as the loading control.

p-eIF2α / ATF4 / CHOP ; 

PubMed: 20072656     


Western blot was performed to evaluate activated eIF2α (P-eIF2α), translational up-regulation of ATF4, and CHOP expression in U251 cells after vorinostat exposure.

p21; 

PubMed: 21598070     


To determine the dose response relationship to vorinostat, cells were exposed to various higher concentrations (5–10 µM) of the agent and the levels of p21 determined by immunoblotting.

21598070 19440035 20072656
Immunofluorescence
HDAC1 / CK19; 

PubMed: 29917299     


Immunocytochemistry to detect the expression of HDAC1 and CK 19 in PDAC cells with/without Vorinostat treatment. HDAC1 and CK19 were stained red and green, respectively. The Hoechst‐stained nuclei appear blue. Scale bar: 100 μm. The CK19 expression in PSN1 and MiaPaCa2 was increased by Vorinostat treatment.

Nrf2; 

PubMed: 20566897     


Vorinostat induced translocation of Nrf2 from cytosol to nucleus. U937 cells were treated with 2μM vorinostat for 18 hours and then cytospun. Cells were fixed and labeled for Nrf2 protein (red) and nucleus (blue, 4,6-diamidino-2-phenylindole) as described in “Immunofluorescence and confocal microscopy.” Images were taken by Nikon Eclipse TE2000 confocal microscope with 40×/1.30 numeric aperture oil objective lens. Ctrl indicates control cells without treatment; and Vor, vorinostat.

α-SMA; 

PubMed: 26330748     


Representative immunofluorescence images and the quantification graph showing the effect of vorinostat (2.5 µM), TGIF1, and TGIF2 siRNA knockdown on αSMA. Control human corneal fibroblast cultures (-TGFβ) showed no αSMA staining. Cultures treated with TGFβ1 (5 ng/ml) showed a robust αSMA staining. Vorinostat treatment markedly attenuated TGFβ-evoked αSMA staining. The knockdown of TGIF1 (+TGFβ+vorinostat+TGIF1siRNA) and TGIF2 alone (+TGFβ+vorinostat+TGIF2siRNA) or in combination (+TGFβ +vorinostat +TGIF1 +2siRNA) markedly blocked the effect of vorinostat on αSMA. Scale bar=100 μm.

Ac-STAT3 / IGF2; 

PubMed: 27086926     


Immunofluorescence staining of Ac-STAT3 and IGF2 after vorinostat treatment.

29917299 20566897 26330748 27086926
Growth inhibition assay
Cell apoptosis; 

PubMed: 19440035     


Cells were treated with indicated concentrations of vorinostat for 48 hours. Following this, the percentage of annexin-V-stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are the mean of 3 experiments plus or minus the standard error (SE)

Cell viability; 

PubMed: 27086926     


The effects of vorinostat on the viability of the indicated NSCLC cell lines and their corresponding acquired VoR sublines. Cell viability was determined by the MTT assay (n = 3).

19440035 27086926
ELISA
IGF2; 

PubMed: 27086926     


Determination of vorinostat-induced IGF2 production by ELISA (n = 3). The conditioned mediums (CMs) obtained from cells treated with vorinostat (5 μM) for 2 days were used for ELISA. 

IL-13 / IL-10 / IL-5; 

PubMed: 18541724     


Effect of vorinostat on TH1/TH2 cytokine secretion in HL cell lines. Cells were incubated with medium or vorinostat (5 μM) for 24 hours and supernatants were examined for cytokine levels by ELISA. Each value represents a mean of 3 independent experiments done in triplicate (± SEM).

M-CSF; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for M-CSF  secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

MMP-9; 

PubMed: 23042302     


Primary PyMT tumor cells were treated with SAHA (0-1000nM) for varying time points (8–48h), and supernatants were assayed by ELISA for MMP-9 secretion. *P < 0.05 and **P < 0.001 versus control treatment. 

27086926 18541724 23042302
In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03022565 Suspended Drug: Vorinostat Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center January 2020 Early Phase 1
NCT03167437 Recruiting Drug: Vorinostat Crohn''s Disease National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) October 30 2017 Phase 1|Phase 2
NCT03056495 Recruiting Drug: N-hydroxy-N''-phenyl-octanediamide (Vorinostat) Alzheimer Disease German Center for Neurodegenerative Diseases (DZNE)|University Hospital Bonn|University of Göttingen September 28 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID