Vorinostat (SAHA, MK0683)

Catalog No.S1047 Synonyms: SAHA, MK0683, suberoylanilide hydroxamic acid

Vorinostat (SAHA, MK0683) Chemical Structure

Molecular Weight(MW): 264.3

Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.

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Cited by 103 Publications

20 Customer Reviews

  • Activity of vorinostat in Jurkat and Peer T-ALL cell lines in an MTT cell viability assay. Cells were treated with increasing drug concentrations for 72 h. The data are plotted as the mean % of DMSO-treated control cells against the corresponding drug concentration. The error bars are the standard error. For each drug and cell line, 3-4 independent experiments were performed with 6 replicates at each drug concentration.

    Nature 2011 471, 235-9. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Differential effects of HDAC inhibitors on histone and tubulin acetylation. Immunofluorescence analysis of histone H3 (K9ac/K14ac) and tubulin acetylation in HeLa cells treated for 4 h with vehicle, SAHA (10 μM), tacedinaline (50 μM), PCI-24781 (20 μM. (a) Mapping of histone acetylation in K562 cells treated with HDAC inhibitors by LC-MS/MS. Cells were treated with TSA (10 μM), SAHA (5 μM), PCI-24781 (2 μM), tacedinaline (50 μM) for 6 h. Histones were extracted from cells and acetylated peptides were quantified after isobaric tagging.

    Nat Biotechnol 2011 29, 255-265. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Western blot analysis of histone H3 acetylation in the spleen of untreated and vorinostat-treated hNF-E2 tg mice (n = 4 of each genotype).

    J Exp Med 2012 209, 35-50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA down-regulates c-FLIP expression and increases the sensitivity of CaP cells to undergo apoptosis in the presence of bicalutamide (A) Bar graph illustrating the sub-G0/G1 cell population in 22Rv1 (left panel) and LNCaP (right panel) cells in the absence and presence of 10μM bicalutamide, administered as a single agent or in ombination with increasing concentrations of the HDAC inhibitor, SAHA. (B) Immunoblots demonstrating the single agent activity of bicalutamide or SAHA, or effect upon their combined administration on the expression of c-FLIP and/or the processing of PARP. Equal protein loading was confirmed by GAPDH. (C) Bar graph illustrating the effect of bicalutamide and SAHA upon the induction of caspase-8 or caspase-3/7 activity in 22Rv1 cells (left panel) and LNCaP cells (right panel). (D) Immunoblots characterizing the impact of SAHA and/or bicalutamide upon the induction of PARP cleavage, in the absence or presence of the pan-caspase inhibitor, ZIETD. ZIETD was incubated with the cells for 12 h prior to the experiment. All data points shown in (A) and (C) represent the mean ± S.E.M. value, calculated from four independent experiments.

    Clin Cancer Res 2012 18, 3822-33. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Analyses of efficacy, potency and IC50 of HDAC inhibitors point toward HDACs 1–3 as relevant candidates for beta cell protection. Ranking and raw data on ITF drugs (Table 3) and commercial HDAC inhibitors (Table 4) underlying the heat maps of Fig. 1 (A and B). The HDAC inhibitor compounds were tested using a HDAC activity kit and recombinant proteins to determine IC50 values on each individual HDAC (right part of the table). Each drug was further tested using Real-Time Cell Analysis (RTCA) to score their maximal effective concentration (ECmax) as well as the corresponding rescue percentage of cytokine treated INS-1 cells. The drugs were ranked according to % rescue. * DMSO alone controls were included in each experiment, but not shown here. The results indicate that the highest concentrations of DMSO used here (1:1,000) were slightly potentiating the proliferation of the cells. The effects observed in this group of compounds were ascribed to the DMSO.?

    Diabetologia 2012 55, 2421-2431. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Suberoylanilide hydroxyamic acid (SAHA) preserves CFP (+) expression in mouse optic nerves (MONs) from older mice. (a) CFP (+) mitochondria were longer and thicker in MONs from 12-month-old Thy-1 CFP mice (inset; scale bar = 2 μm). Oxygen–glucose deprivation (OGD) consistently reduced CFP pixel intensity in 12-month-old MONs despite longer and brighter CFP ( +) mitochondria (yellow arrows). (b) Blockade of AMPA/kain ate receptors with NBQX (30 μM), or pan-Histone deacetylase (HDAC) inhibition with SAHA (5 μM), effectively preserved CFP pixel intensity during OGD. The preservation of CFP (+) mitochondria correlates with protection of the CAP area during OGD and profound recovery.

    J Neurochem 2012 123 Suppl 2, 108-15. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • D and E, Regression of IL-13Ra 2-negative pancreatic tumors treated with SAHA and/or IL-13-PE. Mice were treated daily with i.p. injection of SAHA (25 mg/kg) from day 4 after tumor implantation for two weeks followed by i.t. injection of IL-13-PE (100 μ g/kg) from day 5 for two weeks. F and G, Regression of IL-13Ra 2-posotive pancreatic tumors (HS766T and MIA-PaCa2) treated with SAHA and/or IL-13-PE. The schedule of treatment was similar as in panel D and E. Statistical significances are shown by *: P < 0.05,†: P < 0.001.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

    IL-13Rα2 expression is upregulated in pancreatic tumors but not in organs of mice after treatment with HDAC inhibi tor, SAHA. A, qRT-PCR of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. Tumors were harvested next day after IL-13-PE treatment and total RNA extracted. Data shown is ratio of human IL-13Rα2/β-actin expression and multiplied by 1000 for convenience. Bars , SD of triplicate determinations. B, qRT-PCR of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Tissues were harvested at the same time point as in panel A and total RNA extracted. Data shown is ratio of mouse IL-13Rα2/β-actin expression and multiplied by 100 for convenience. C, IHC of human IL-13Rα2 in implanted pancreatic tumors after SAHA and IL-13-PE treatment. D, IHC of mouse IL-13Rα2 in mice organs after SAHA and IL-13-PE treatment. Liver, brain, kidney, pancreas, lung and spleen were fixed for immunostaining of mouse IL-13Rα2 as visualized by Alexa555. Nucleus was counterstained by DAPI.

    J Transl Med 2011 9, 37. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Proliferation o f HT29 and HCT116 cells after 48 h of butyrate or SAHA treatment. Proliferation measurements using the xCEL Ligence RTCA DP instrument (Roche) in cells treated with increasing doses of butyrate or SAHA, compared with control medium cells (0) (*P < 0.05). The mean ?SEM of three cell culture replicates is shown.

    Mol Carcinog 2012 52, 459-74. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA induces the down-regulation of cFLIP expression and promotes TRAIL-mediated activation of a mitochondrial-operated apoptotic pathway. a BT-474 cells were treated as indicated in Fig. 1 and the cells were then harvested to analyse caspase-8, Bid, caspase-9, caspase-3 and PARP expression, using GAPDH as the protein loading control. b BT-474 cells were treated with SAHA for 8 h at the doses indicated and subsequently, the cells were harvested and the apoptosis-related proteins were analysed in western blots as described in the "Materials and Methods". The results shown are representative of at least three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Treatment with SAHA sensitizes breast cancer cells to TRAILinduced apoptosis. BT-474 and MDA-MB-231 cells were incubated for 8 h with SAHA at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some of the cultures for an additional 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content as described in the "Materials and methods". The results show the mean and S.E.M. of three independent experiments

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    SAHA facilitates the Itch/AIP4-independent proteasomal degradation of cFLIP proteins in breast cancer cells. a BT-474 cells were treated with SAHA (5 μM) for 8 h in the presence or absence of the proteasome inhibitors MG132 or epoxomicin (at the doses indicated), and they were then harvested and the cFLIP content was analysed in western blots. b BT-474 cells were transfected with either the siRNA oligonucleotides targeting Itch/AIP4 or the non-targeting RNA oligonucleotide (scrambled) for 48 h as described in the "Materials and Methods". Subsequently, the cells were treated with SAHA (5 μM) for 8 h and then cFLIP and Itch/AIP4 expression was analysed in immunoblots

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • cFLIP down-regulation following SAHA treatment is responsible for the sensitization of breast cancer cells to TRAIL. a BT-474 cells were transfected with either different siRNAs directed against the cFLIP isoforms or the non-targeting RNA oligonucleotide (scrambled) as described in the "Materials and Methods". After 24 h, the cells were treated with TRAIL (500 ng/ml) for a further 15 h and apoptosis was then measured as the percentage of cells with subG1 DNA content. The results show the mean and S.E.M. of three independent experiments. To verify protein knockdown, cells were harvested 24 h after transfection and the cFLIP levels were assessed in immunoblots. b. BT-474 cells overexpressing Cflipl (pBABE-FLIPL) or control cells (pBABE) were treated with SAHA for 8 h at the doses indicated. After this time, TRAIL (500 ng/ml) was added to some cultures for 15 h. Apoptosis was measured as the percentage of cells with subG1 DNA content and the results show the mean and range of two independent experiments. Western blots show the cFLIP levels after SAHA treatment in pBABE and pBABE-FLIPL cells.

    Invest New Drugs 2012 30, 541-547. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Vorinostat inhibits the tumor growth. NOD ⁄ SCID-B2m-/-mice were injected s.c. with 1×106 MyLa2059 cells into both flanks. When the mice had developed established palpable tumors treatment was initiated (day 1). The mice received either vehicle (black line) or 60 mg ⁄ kg vorinostat (grey line) i.p. five days a week. In total, there were four mice in the group receiving vehicle and three mice in the group receiving vorinostat. The length and width of the tumors were measured continuously until the experiment was terminated on day 20 post treatment initiation. The tumor volume was calculated using the formula V = (a×b2)/2, where a defines the length (mm) and b the width (mm) of the tumor. The histogram shows the average tumor volume per flank ± SEM. * denotes a significant difference (P < 0.05) in the average tumor volume per flank between mice treated with vehicle and vorinostat at the given time-point both by using a one-tailed two samples test with Welch, scorrection and a Mann-Whitney U test.

     

     

    Exp Dermatol 2010 19, 1096-1102. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Western blot of whole cell extracts demonstrates SAHA and NaB treatment result in increased levels of acetylated histone H3 compared to vehicle controls. (b) Light micrographs of HDACi/vehicle treated cultures illustrate the paucity of neurospheres in HDACi-treated cultures. (c) Quantitative analysis confirms SAHA and NaB inhibit the formation of neurospheres (diameter ≥ 50 μm) and increase the prevalence of small cell clusters (≥ 4 cell, diameter < 50 μm). (d) Flow cytometry using LIVE/DEAD cell stain confirms SAHA and NaB are minimally toxic compared to vehicle controls (n = 3). Scale bar = 100 μm.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    (a) EdU flow cytometry of live cell-gated adult mouse NSCs demonstrates SAHA (**p < 0.01) and NaB (***p < 0.001) significantly inhibit DNA synthesis. (b) Analysis of DNA content by flow cytometry reveals significant accumulation of adult mouse NSCs in G1phase of the cell cycle following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (c) Correspondingly the proportion of cells in G2/M phase is significantly reduced following SAHA (*p < 0.05) and NaB (*p < 0.05) treatment. (d) Fluorescence micrographs of HDACi/vehicle treated adult NSCs pulse-labeled with EdU for flow cytometry. Scale bar = 50 μm. Statistical comparisons performed using one-way ANOVA with post hoc Newman-Keuls multiple comparison tests.

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • (a) Immunofluorescence labeling of NeuN, GFAP and Olig2 cell fate markers reveals reduced expression of GFAP (*p < 0.001) and Olig2 (*p < 0.05) in adult mouse NSCs treated with SAHA for 48 hours under proliferation culture conditions and then induced to differentiate for 14 days in culture (two-way ANOVA with Bonferroni post-tests). (b) Western blot of β-catenin protein in nuclear and cytoplasmic fractions of adult mouse NSCs treated with HDACi/vehicle control under proliferation culture conditions. Gapdh and lamin A/C blots are included as loading controls. (c) SAHA and NaB do not significantly alter nuclear/cytoplasmic levels of β-catenin in adult mouse NSCs. Histogram of β-catenin Western blot signal intensities normalized to loading controls (n = 4).

    BMC Neurosci 2011 12, 50. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Morphological changes and histone H3 phosphorylation of HB cells treated with a combination of VX-680 and SAHA. HUH6 and HepT1 were incubated with VX-680 (6 μM) and SAHA (0.5 μM). Nuclei diameter (a) and cell diameter (b) were determined 72 h later by DAPI staining and microscopy. Data represent mean±SD of the diameters from 20 cells in each experiment. (* Two-way ANOVA, Bonferroni test, p \0.05). c Western blot analysis on HUH6 and HepT1 cells were carried out with an anti-phospho-Histone H3 (Ser 10) antibody (p-H3) 24 h after incubation with VX-680 (10 μM), SAHA (0.2 μM) or a combination of both. Controls were left untreated. Western blot analysis showed a decrease in p–H3 after treatment with VX-680 ( lane 2 ) relative to controls ( lane 1 ) and an increase when SAHA was added ( lane 3 ). For the combination of VX-680 and SAHA (lane 4 ) no p-H3 was detected.

    Pediatr Surg Int 2012 28, 579-89. Vorinostat (SAHA, MK0683) purchased from Selleck.

  • Vorinostat promotes C2C12 differentiation.In the image, the red is the myotube indicating differentiation ,the blue is the nuclei.

     

     

    Dr. Akihiko Yoshimura of Akihiko Yoshimura. Vorinostat (SAHA, MK0683) purchased from Selleck.

    Western blot analysis of Acetyl-H3 and H3. 0-20μM SAHA was added.

     

     

    Dr. Zhang of Tianjin Medical University. Vorinostat (SAHA, MK0683) purchased from Selleck.

Purity & Quality Control

Choose Selective HDAC Inhibitors

Biological Activity

Description Vorinostat (suberoylanilide hydroxamic acid, SAHA) is an HDAC inhibitor with IC50 of ~10 nM in a cell-free assay.
Targets
HDAC [1]
(Cell-free assay)
~10 nM
In vitro

Vorinostat inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively. Vorinostat also results in a marked hyperacetylation of histone H4. [1] Vorinostat inhibits the growth of three prostate cancer cell lines LNCaP, PC-3 and TSU-Pr1 at micromolar concentrations (2.5-7.5 μM), and induces dose-dependent cell death in LNCaP cells. [2] Vorinostat treatment in MCF-7 cells inhibits cell proliferation at an IC50 of 0.75 μM resulting in the accumulation of cells in the G1 and G2-M phase of the cell cycle. Vorinostat also induces differentiation in the estrogen receptor-negative cell line SKBr-3 and the retinoblastoma-negative cell line MDA-468. [3] Vorinostat treatment at 1 μM for 8 hours or more is sufficient to irreversibly induce apoptosis of human multiple myeloma (MM) cells. The gene expression profiles of Vorinostat treated MM cells are not hallmarked by global transcriptional activation, but by coordinated transcriptional changes of specific functional groups of genes such as cytokine-induced proliferative/survival signaling cascades, oncogenes-tumor suppressor genes, regulators of apoptosis, DNA synthesis-repair and cell cycle, and proteasome-ubiquitin function. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
A20 M4CwcWtqdmG|ZTDBd5NigQ>? MVexJIg> NWXUU|dmTE2VTx?= MVLhcpRqNUiGQVOxJIFkfGm4aYT5JJdqfGhiSVO1NEBw\iByLkGxNkDPxE1? M{nkelEyQTZyNEi5
Friend leukemic cell M{T0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjLeow2OCEQvF2= M2PoS|czKGh? MVTEUXNQ NFfuNGVKSzVyPUCuPVkh|ryP M4Czd|EzOTB7OUGz
K562 NYDBbGpxU2mwYYPlJGF{e2G7 NUHmdnJoPiCq M3XJbWROW09? MkDyTY5pcWKrdHnvckBw\iCqdX3hckBpcXO2b37lJIRm[WOndInsZZNmKCivaYj0eZJmKG:oIFjERWMyKGGwZDDISGFEOilid3n0bEBKSzVyIH;mJFAvODFizszN MV:xNlQyQTN6MB?=
HT1080 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnZWZM4OiCq MnjPSG1UVw>? MV7JR|UxRTJwNDFOwG0> NID6UGkyOjJ5MEG3OS=>
H1299 NW\rb2NXU2mwYYPlJGF{e2G7 NEnVOXEzOCCvaX6= MojpSG1UVw>? Mn3JTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGhFSUNiZX76fY1mKHerdHigTWM2OCCxZjCwMlE6PCEQvF2= M1THclE1PTJzNEKy
H1299 M2XtXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7QO|IhcA>? NEjHNJpFVVOR MmDrTWM2OD15LkK0JO69VQ>? MVWxOFUzOTR{Mh?=
HeLa MV;LbY5ie2ViQYPzZZk> MXSzNEBucW5? NXzW[YRnUW6qaXLpeI9zgSClb37j[Y51emG2aX;uJIFo[Wmwc4SgbIl{fG:wZTDk[YFk\XS7bHHz[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? MmfBNVU3ODN7NEm=
LOX-IMVI NF3xZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmzOFghcA>? NEj3S21KSzVyPUGuN{DPxE1? NXPNemxFOTV5MUW0O|A>
NCI-H226 NI\icnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX20PEBp NEO1S4JKSzVyPUKuOkDPxE1? MUmxOVcyPTR5MB?=
RXF-631L M2DsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7FbYoxPDhiaB?= Mnq0TWM2OD1{IN88US=> M{PUT|E2PzF3NEew
SNB-78 M4PpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jtZ|Q5KGh? M3OxSWlEPTB;MU[g{txO NUPST5RYOTV5MUW0O|A>
St-4 MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUi0PEBp MoPuTWM2OD13LkKg{txO MkfuNVU4OTV2N{C=
ARP1 M3;KZmZ2dmO2aX;uJGF{e2G7 MofjNkDPxE1? NF7WWm43KGh? NYjWWGhFUW6mdXP0bY9vKG:oIGCyNXdCTjFiZ3Xu[UBmgHC{ZYPzbY9v NXLueWE3OTR5M{S4NFY>
CEM MoHUT4lv[XOnIFHzd4F6 MmTpNUBp MVXEUXNQ Mn:xTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLkOzJO69VQ>? NGPQPZoyPjR{MEC2OC=>
HCT15 NXe4TWZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXi0PEBp MXvHTVUxRTBwOEKg{txO MmXkNVY4OjN{Mke=
NCI-H23 MnLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoKxOFghcA>? NV;MPYM3T0l3ME2wMlkzKM7:TR?= MXmxOlczOzJ{Nx?=
GM15850 Mk\OT4lv[XOnIFHzd4F6 M1rHWVIvPSEQvF2= MYW5OkBp MkLCSG1UVw>? NHvIPIdKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIN{BtgXOrbnWgNVQh[WOndInsZZRqd25ib3[gSnhPKGenbnW= Mn3xNVY6OjF|Nke=
GM15850 M{HxUWtqdmG|ZTDBd5NigQ>? MUmyMlUh|ryP M2fsdFk3KGh? NVyxO2ZpTE2VTx?= M2PsXmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC1JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n M1\VOVE3QTJzM{[3
GM15850 NEK0d2ZMcW6jc3WgRZN{[Xl? NXnCNGlVOi53IN88US=> MoXIPVYhcA>? NWLKeHZvTE2VTx?= M3nufWlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTCxNkBi[2W2eXzheIlwdiCxZjDGXG4h\2WwZR?= M1X3OVE3QTJzM{[3
GM15850 NF;IUZpMcW6jc3WgRZN{[Xl? NIHKfVgzNjVizszN NUPHUGo6QTZiaB?= MmHiSG1UVw>? NYHzS21tUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NYn3enh7OTZ7MkGzOlc>
GM15850 MlnsT4lv[XOnIFHzd4F6 M1vwfFIvPSEQvF2= MnGyPVYhcA>? NILGUJRFVVOR M3f6UGlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFi0JIx6e2mwZTC4JIFk\XS7bHH0bY9vKG:oIF\YUkBo\W6n Mo\nNVY6OjF|Nke=
GM15850 M1\0OmtqdmG|ZTDBd5NigQ>? Mmm3Nk42KM7:TR?= NU\i[FNwQTZiaB?= NEDyU2tFVVOR MV;Jcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaHnzeI9v\SCKNDDsfZNqdmViMU[gZYNmfHmuYYTpc44hd2ZiRmjOJIdmdmV? MoPoNVY6OjF|Nke=
U937 MkHUSpVv[3Srb36gRZN{[Xl? MV[1JO69VQ>? NX3RPGZQOjRiaB?= MW\EUXNQ M2DzfmNmdGxiY4njcIUh[XK{ZYP0JIJ6KGGlY4XteYxifGmxbjDheEBUN0d{L12gdIhie2V? M4\BO|E4ODB2N{G4
H661 NXnURVQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLDb3M1QCCq MmOxTWM2OD1zIN88US=> NFrtSngyPzF3N{CwPS=>
U937 NHnwT25HfW6ldHnvckBCe3OjeR?= MkLEOUDPxE1? Mnm4NlQhcA>? NVnMbHVNTE2VTx?= M33ERWlv[3KnYYPlJIlvKGirc4TvcoUhUDNiYXPleJlt[XSrb36= NVzF[FBbOTd2NEe3OVA>
U937 NYi4NYdsTnWwY4Tpc44hSXO|YYm= MVWxJO69VQ>? NILLWG4zPCCq MYXEUXNQ M4q4dWVn\mWldDDvckBidHCqYTD0eYJ2dGmwIHHj[ZR6dGG2aX;u MW[xO|Q1Pzd3MB?=
RAW264.7 MUXGeY5kfGmxbjDBd5NigQ>? MXuxNEDPxE1? NWHTelczOjSq Mnr3e4F1\XJ? MYfJcohq[mm2aX;uJI9nKEySUz3zeIlufWyjdHXkJHRPTmGucHjhJJBzd2S3Y4Tpc44hf2m2aDDJR|UxKG:oIECuO|Yh|ryP NF7FVXgyPzR5N{WxPC=>
RAW264.7 M{LnU2Z2dmO2aX;uJGF{e2G7 MUmxNEDPxE1? M13ER|I1cA>? M{mwfpdifGW{ NHfsVJFKdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKE6RIIDyc4R2[3Srb36ge4l1cCCLQ{WwJI9nKDFwOEig{txO MnGzNVc1Pzd3MUi=
SC9 NEPTWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPIV5VXPDhiaB?= MVvJR|UxRTBwNkC2JO69VQ>? Mlz6NVc2ODd{MUm=
ST14A M3HJR2Z2dmO2aX;uJGF{e2G7 MXe1JI5O NVv0c3o5PzJiaB?= MYnJcoNz\WG|ZTDpckBTTVOWL17SV2YhdVKQQTDlfJBz\XO|aX;u M4fnZlE4PTZ3OUmz
ST14A M1rBZmZ2dmO2aX;uJGF{e2G7 NInUUoE2KG6P MkTwO|IhcA>? MV3JcoNz\WG|ZTDpckBGOkZzIH3SUmEh\XiycnXzd4lwdg>? MWGxO|U3PTl7Mx?=
PANC1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX4[WFXOSEQvF2= MnjJTWM2OD1yLkS1JO69VQ>? Ml;5NVc2QDh5NES=
PANC1 MV7GeY5kfGmxbjDBd5NigQ>? MYCxJO69VQ>? M1nafVI1KGh? NWHtWm91UW6lcnXhd4UhcW5icEKxW2FHOS:FSWCxJIdmdmViZYjwdoV{e2mxbh?= NH;jflEyPzV6OEe0OC=>
PANC1 MYHGeY5kfGmxbjDBd5NigQ>? M{DzTFEh|ryP M2rnO|I1KGh? M{\ZW2lv[3KnYYPlJIlvKHB{N3vpdFEh\2WwZTDlfJBz\XO|aX;u M4TyWVE4PTh6N{S0
PT45 NVvqUHptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTZTWM2OD12IN88US=> NVm3c29SOTd3OEi3OFQ>
ACHN Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4S5OFIyKGh? M4DxV2dKPTB;MD62OUDPxE1? M2fEbVE4PjZ{NkC2
PC3 M{PoNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXMdZB6OjFiaB?= M13tcGdKPTB;MD63NUDPxE1? Mle2NVc3PjJ4ME[=
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SKHEP1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\lWWU4OiCq NF;EVZNKSzVyPUOuOFYh|ryP NHX5b2EzODF2M{e3PC=>
BJ NUHJW|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr2UY8yODBizszN MXK0PEBp M3HrR2ROW09? NHfkbXhIem:5dHigbY5pcWKrdHnvckBifCByLkC1JJRwKDFyMDD1US=> NV\IU2tDOjBzNEO4OFA>
MUF MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXSxNFAh|ryP MVy0PEBp MnPvSG1UVw>? NVrReGx6T3Kxd4ToJIlvcGmkaYTpc44h[XRiMD6wOUB1dyBzMECgeW0> M3rFc|IxOTR|OESw
Caco-2 NIK2U5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jpVlExOCEQvF2= MYG0PIg> MmXNSG1UVw>? MXTJR|UxRThwMTFOwG0> M1OxZlIxOTR|OESw
Caco-2 NGrJT3NMcW6jc3WgRZN{[Xl? NFfBdJk2KM7:TR?= MV[0JIg> M1rV[GROW09? NV;KOoQ1UW6mdXP0bY9vKG:oIFjERWMudWWmaXH0[YQhcGm|dH;u[UBi[2W2eXzheIlwdiCLQ{WwJI9nKDBwMEO3JO69VQ>? M{H2NFIxOTR|OESw
Caco-2 M1L3UmtqdmG|ZTDBd5NigQ>? MUGwMlMyPiCwTTD0c{A{OS54IN88US=> MnTTOEBp M3PpTWROW09? NI[xb2xGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Gge4l1cCCLQ{WwJI9nKDBwMUG5JO69VQ>? MXSyNFE1Ozh2MB?=
Caco-2 NFTac5JMcW6jc3WgRZN{[Xl? NHf3WmUxNjNzNjDuUUB1dyB|MT62JO69VQ>? M4\FN|QhcA>? MVfEUXNQ NIjKNZhGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{Oge4l1cCCLQ{WwJI9nKDBwMUS3JO69VQ>? NYnLc2R{OjBzNEO4OFA>
Caco-2 NV7uVI05U2mwYYPlJGF{e2G7 MYi2MlMzKG6PIITvJFY{OiEQvF2= MnzqOEBp NHXlZVlFVVOR MYjFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzVid3n0bEBKSzVyIH;mJFEzNjZizszN MojmNlAyPDN6NEC=
Caco-2 M3vrbmtqdmG|ZTDBd5NigQ>? NGLMRYM3NjN{IH7NJJRwKDZ|MjFOwG0> MoDEOEBp MmTkSG1UVw>? MXvFfEB3cX[xIHnubIljcXSrb36gc4YhcHWvYX6gTGRCSzdid3n0bEBKSzVyIH;mJFQyKM7:TR?= NH\MNVUzODF2M{i0NC=>
Caco-2 M3\tNGtqdmG|ZTDBd5NigQ>? MnnUNE4{OTZibl2geI8hOzFwNjFOwG0> NYPXepFMPCCq NUGwNYlnTE2VTx?= NICxUVhGgCC4aY\vJIlvcGmkaYTpc44hd2ZiaIXtZY4hUESDQ{[= M{L5dlIxOTR|OESw
HepG2 M3u1bmtqdmG|ZTDBd5NigQ>? M{\EeVUh|ryP NUDPdWxPPmh? MYfEUXNQ NFTYWpRKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIFk\XS7bHH0bY9v MVuyNFE1Ozh2MB?=
HepG2 NF[3UJBMcW6jc3WgRZN{[Xl? NX60dIV4PSEQvF2= M3W2PFZp M1\rOGROW09? NFe5TpZKdmS3Y4Tpc44hd2ZiSFTBR{1u\WSrYYTl[EBpcXO2b37lJIh6eGW{YXPleJlt[XSrb36= MUmyNFE1Ozh2MB?=
HepG2 NY\YbFhSU2mwYYPlJGF{e2G7 MWW1JO69VQ>? NUTzeYlPPmh? M{nBUmROW09? M3SzVmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MYWyNFE1Ozh2MB?=
HepG2 NXHnRoJ6U2mwYYPlJGF{e2G7 M3H1fFUh|ryP NGDC[GU3cA>? Mn3hSG1UVw>? M4Lhdmlv\HWldHnvckBw\iCKRFHDMY1m\GmjdHXkJGg{N0h2IHjpd5RwdmViYXPleJlt[XSrb36= NE[4PZMzODF2M{i0NC=>
COLO205 NGKyclRMcW6jc3WgRZN{[Xl? NYmzeXZ[OTBizszN M3HG[FI1KGh? Ml;zSG1UVw>? NVGwcHB{UW6qaXLpeIlwdiCxZjDISGFEOSCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhcGm|dH;u[UBJOyCjY3X0fYxifGmxbjD3bZRpKEmFNUCgc4YhOi5{IN88US=> NY\pZZV{OjB2NUGzO|g>
SCC4 NVnCOoV1U2mwYYPlJGF{e2G7 NICzPXAyKM7:TR?= Mmf0NlRp NFPB[JFKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6geJVjfWyrbjDhZ4V1gWyjdHnvci=> M1XH[FIxPDV{MkK1
SCC4 MkfsT4lv[XOnIFHzd4F6 NXjZc|BiOSEQvF2= MVKyOIg> NF6wTYVKdmirYnn0bY9vKG:oIFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDhZ4V1gWyjdHnvci=> Ml3DNlA1PTJ{MkW=
SCC4 MoTOSpVv[3Srb36gRZN{[Xl? M2nBflEh|ryP M4fiOlUhdWmw MXLB[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhS1mSMkSg[4Vv\SCneIDy[ZN{cW:w MW[yNFQ2OjJ{NR?=
NB4 NUP4UGIyTnWwY4Tpc44hSXO|YYm= NF3yTIg2KM7:TR?= NHTjfXgzPCCq M3vlfWROW09? MVLD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCjY3P1cZVt[XSrb36gZZQheHKnLVexJJBp[XOn Mle5NlA1QTF2NEC=
NB4 MkLnT4lv[XOnIFHzd4F6 NWn0dXlsPSEQvF2= MlLYNlQhcA>? MYDEUXNQ NVrUc4VMUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIFk\XS7bHH0[UB1fWK3bHnuJIxmfmWu NXn0R4pvOjB2OUG0OFA>
NB4 M3vTc2Z2dmO2aX;uJGF{e2G7 MkHJOUDPxE1? MnLLNlQhcA>? M3zMNmROW09? M1nDR2lv\HWldHnvckBw\iCyMkHXRWYyN0OLUEGg[ZhxemW|c3nvci=> NVzsVppGOjB2OUG0OFA>
NB4 NYHaT3ZMU2mwYYPlJGF{e2G7 MojYOUDPxE1? NXXKXGtFOjRiaB?= M3KwRWROW09? M1XwcmlvcGmkaYTpc44hd2ZiSFTBR{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDobZN1d26nIFizJIFk\XS7bHH0bY9v MVGyNFQ6OTR2MB?=
NUGC3 NIfzeYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\4XJhxT0l3ME2yMlk1KM7:TR?= MnjzNlA5PTB7N{G=
A549 MWHGeY5kfGmxbjDBd5NigQ>? NGmz[3o2KM7:TR?= MnXaN{Bp M2i0XGROW09? MmOyTY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKEyFM1nJ M3PwTlIxQDV3MkC4
HUT78 M{\WfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;o[lczKGh? NGDqVZhFVVOR NF;BXXlIUTVyPUCuN{DPxE1? M1TVUVIxQDh2MkC4
U937 NEjpWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnkNJo4OiCq M2nMXGROW09? NXj3N5gzT0l3ME2wMlM6KM7:TR?= NHv0O48zODh6NEKwPC=>
A431 MnzqR5l1d3SxeHnjJGF{e2G7 NH;lR4s4OiCq NFvTc3ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGVITlJid3n0bEBKSzVyIH;mJFQvOiEQvF2= M3rrVVIyODhyNkK5
A549 MWnDfZRwfG:6aXOgRZN{[Xl? M3rVb|czKGh? NHjpT41EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvQCEQvF2= MkjsNlExQDB4Mkm=
CAL27 MYPDfZRwfG:6aXOgRZN{[Xl? MkW0O|IhcA>? MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDDRWwzPyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKHerdHigTWM2OCCxZjCzMlIh|ryP NUDwdIs1OjFyOEC2Nlk>
HeLa MnrzR5l1d3SxeHnjJGF{e2G7 NIP5T2Q4OiCq NIT6WJREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\UyjIHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNid3n0bEBKSzVyIH;mJFEvPSEQvF2= M1zlNFIyODhyNkK5
Sf21 NGjOb4ZMcW6jc3WgRZN{[Xl? NELUT5A{KGh? MnmxTY5pcWKrdHnvckBw\iCIbHHnJJRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDISGFEQCCneIDy[ZN{\WRid3n0bEBKSzVyIH;mJFEvOiEQvF2= NYftfZNSOjFyOEC2Nlk>
SKBR3 MlzYR5l1d3SxeHnjJGF{e2G7 MmHJO|IhcA>? MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKHerdHigTWM2OCCxZjCyMlYh|ryP NGXEUmEzOTB6ME[yPS=>
SKOV3 NY\vSZBsS3m2b4TvfIlkKEG|c3H5 M2mwVVczKGh? MoDsR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV2tQXjNiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTOiC5aYToJGlEPTBib3[gNk4zKM7:TR?= M{fUXFIyODhyNkK5
COR-L23 NGq0d41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nnd|ExKM7:TR?= NUf4R5hxPzJiaB?= MnzvSG1UVw>? M{HF[mdKPTB;MT6xJO69VQ>? NUX5dHg5OjFyOEC2OFc>
DU145 NVHEW3EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\kNVAh|ryP MnvuO|IhcA>? NI[2T2lFVVOR Mly5S2k2OD1zLkC1JO69VQ>? M{HuN|IyODhyNkS3
LoVo M1HYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUmxNEDPxE1? NFPMUHU4OiCq NFvue3VFVVOR MUfHTVUxRTFwNzFOwG0> MnLlNlExQDB4NEe=
MCR5-SV2 NYX3cIdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHtXIlKOTBizszN NXS1NotUPzJiaB?= NH;IOlJFVVOR NVvtZpVFT0l3ME2yMlEh|ryP NVPH[XUxOjFyOEC2OFc>
HCT116 M3HTVGtqdmG|ZTDBd5NigQ>? M{C3VFMxKM7:TR?= MoS5N|AhcA>? MmfjSG1UVw>? M{\WOWlvcGmkaYTpc44hd2ZiSFTBR|Yh[XO|ZYPz[YQh[XNiaX7keYN1cW:wIH;mJIFteGijLYT1ZpVtcW5iYXPleJlt[XSrb36= MVeyNVA5ODZ2Nx?=
HCT116 M4Phc2tqdmG|ZTDBd5NigQ>? M4nzb|MxKM7:TR?= MmHZN|AhcA>? NHvlU5hFVVOR NGna[G9KdmirYnn0bY9vKG:oIFjERWMyKGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBpcXO2b37lJGg{UzliYXPleJlt[XSrb36= MVSyNVA5ODZ2Nx?=
U937 NIrmW4ZMcW6jc3WgRZN{[Xl? NXW3bZBbPSEQvF2= M{W2[FI1KGh? NEn6THhFVVOR Ml3FTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIFk\XS7bHH0bY9vKG:oIHjpd5RwdmViSEOgZZQhUzl? NYnBR24xOjF{OUK0PVI>
U937 M3\NR2tqdmG|ZTDBd5NigQ>? MXK1JO69VQ>? NVHLPZdGOjRiaB?= NFHJSXFFVVOR MXPJcohq[mm2aX;uJI9nKGirc4TvcoUh[WOndInseJJidnOoZYLhd4Uh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[gZYNmfHmuYYTpc44hd2ZiaHnzeI9v\SCKMzDheEBMOTh? MnrTNlEzQTJ2OUK=
U937 MWLLbY5ie2ViQYPzZZk> NHX6[2Q2KM7:TR?= NXS2cFdZOjRiaB?= MWDEUXNQ NYDhUHhqUW6qaXLpeIlwdiCxZjDobZN1d26nIHHj[ZR6dHS{YX7z[oVz[XOnIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHCjbj3hZ4V1gWyjdHXkJIhqe3SxbnWgTFQhdGW4ZXy= MUiyNVI6OjR7Mh?=
U937 MVjLbY5ie2ViQYPzZZk> M{TwN|Uh|ryP NUezdINnOTVibXnu NI[2VmVFVVOR MnzSTY5pcWKrdHnvckBw\iCqaYP0c45mKGGlZYT5cJRz[W6|ZnXyZZNmKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIH;mJIhqe3SxbnWgTFMh[WOndInsZZRqd25ibHX2[Yw> MlHtNlEzQTJ2OUK=
A2780 NVXBWolkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL6PVYhcA>? MoTmSG1UVw>? MYHJR|UxRTFwNkKg{txO M3LrTlIyPjN2NEOw
COLO205 MoPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7sNFQ{QTZiaB?= MWnEUXNQ M1TlWGlEPTB;Mj6xNkDPxE1? NFu4dXEzOTZ|NESzNC=>
Hep3B NVn3Ro1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVO0PEBp NUe5dGRmTE2VTx?= Mk\zS2k2OD1zLkKxJO69VQ>? NV7UTpBkOjF5MUKxOFY>
GM11272 M2D1[WZ2dmO2aX;uJGF{e2G7 NUHjc4tkOTByIH7N MlK3O|IhcA>? NUn3dVRHTE2VTx?= NGnpOG9T\WGldHn2ZZRqd25ib3[gUYVEeDJibYX0ZY51KGW6cILld5Nqd25iYYSgNVAhfG9iMUCwJI5O MkjYNlE5PDB5MU[=
CFBE41o M1naUGtqdmG|ZTDBd5NigQ>? M1flelUh|ryP NGTxZ2FFVVOR M1zDRWRwf25icnXneYxifGmxbjDv[kBJTEGFNzDheEAxNjJidH:gOUB2VQ>? M1fIUVIyQTh2OUW4
CFBE41o M{THUWZ2dmO2aX;uJGF{e2G7 NEfV[|kyKM7:TR?= NEPzWXczPCCq MXTEUXNQ NEPWWXlT\XO2b4LheIlwdiCxZjDDSnRTKGSnbIThSlUxQCCvdYThcpQhfHKjZn\pZ4tqdmdidH:gZ4VtdCC|dYLmZYNmKGG|IHfsfYNw\m:{bYO= M3HWWVIyQTh2OUW4
DU145 NX\mcYlxU2mwYYPlJGF{e2G7 MViyMlUh|ryP MYCyOEBp NXn0[oRrTE2VTx?= NWf3[JdyUW6qaXLpeIlwdiCxZjDISGFEKGG|c3Xzd4VlKGG|IIXwdoVofWyjdHnvckBw\iCyMkH3ZYYyKHC{b4TlbY4h\XiycnXzd4lwdg>? NUnTd2tmOjJ{NkCxOlY>
DU145 MV;LbY5ie2ViQYPzZZk> NV;aOIpSPSEQvF2= M4fR[lI1KGh? NUPP[lk4TE2VTx?= MWXJcohq[mm2aX;uJI9nKEiGQVOgZZN{\XO|ZXSgZZMhcGm|dH;u[UBJPCCjY3X0fYxifGmxbh?= NWfQZVY{OjJ{NkCxOlY>
DU145 M3f3eGtqdmG|ZTDBd5NigQ>? MkTkOUDPxE1? M2nqdFI1KGh? MnO4SG1UVw>? Mm\NTY5pcWKrdHnvckBw\iCKRFHDJIF{e2W|c3XkJIF{KGirc4TvcoUhUDNiaInw[ZJi[2W2eXzheIlwdg>? MX2yNlI3ODF4Nh?=
786-0 NUHUSW97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HL[VYvOiEQvF2= MVO3NkBp MYPEUXNQ MlfrS2k2OD1|LkKg{txO MXuyNlQ{PTZ4OR?=
A498 M1TwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3BOk4zKM7:TR?= MVe3NkBp M3n6c2ROW09? NGrhNGpIUTVyPUGuOkDPxE1? NFSzWJgzOjR|NU[2PS=>
A549/ATCC NETjbW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUe2MlIh|ryP Mn7pO|IhcA>? NV7ZeINwTE2VTx?= MojJS2k2OD1zLk[g{txO MX6yNlQ{PTZ4OR?=
ACHN NF\peYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfPPYFFPi5{IN88US=> M3qwXFczKGh? MmTrSG1UVw>? NHH2epFIUTVyPUGuN{DPxE1? NYTVbW06OjJ2M{W2Olk>
BT549 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPzdIc3NjJizszN M4DNOVczKGh? MkXHSG1UVw>? NGS4N2VIUTVyPUGuN{DPxE1? NHPuXGIzOjR|NU[2PS=>
EKVX NH\iWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnScmlpPi5{IN88US=> NEe5Xoo4OiCq MWnEUXNQ MWTHTVUxRTFwMzFOwG0> MkDGNlI1OzV4Nkm=
HCT15 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHYOk4zKM7:TR?= MVm3NkBp MlHDSG1UVw>? MlLyS2k2OD1{LkWg{txO NHv3clQzOjR|NU[2PS=>
HOP92 M1T5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjV[m9WPi5{IN88US=> NX7mRZlIPzJiaB?= M2H2[WROW09? M2m3TmdKPTB;NDFOwG0> M4qyWlIzPDN3Nk[5
IGROV1 NFz2OI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVy2MlIh|ryP NG\OTVA4OiCq MUXEUXNQ Mli4S2k2OD1zLkOg{txO NU\xeHRiOjJ2M{W2Olk>
LOXIMVI MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vqe|YvOiEQvF2= MVK3NkBp NIr3SHdFVVOR MnzqS2k2OD1zIN88US=> Mn;uNlI1OzV4Nkm=
M14 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfFOk4zKM7:TR?= M2nn[FczKGh? MXzEUXNQ NFjRN3FIUTVyPUGuN{DPxE1? NV:4SFdlOjJ2M{W2Olk>
MALME-3M NFntToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrU[2k3NjJizszN NIfkSFc4OiCq MXvEUXNQ MXrHTVUxRTBwM{Kg{txO MWOyNlQ{PTZ4OR?=
MCF10A M3;kUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUe2MlIh|ryP Ml\uOFghcA>? M3r0[GROW09? M1P1WGdKPTB;OT62JO69VQ>? M2WwO|IzPDN3Nk[5
MDA-MB-435 M1y0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjo[XU3NjJizszN MYm3NkBp MnH6SG1UVw>? NEDKcXdIUTVyPUCuOUDPxE1? MVqyNlQ{PTZ4OR?=
MDA-MB-468 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoP6Ok4zKM7:TR?= MWS3NkBp NFO4OXdFVVOR NHi0[GlIUTVyPUCuOlMh|ryP NXTaRpRoOjJ2M{W2Olk>
MOLT4 NWXVO5d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYK2MlIh|ryP NWTjSFBOPzJiaB?= NIfMUWhFVVOR MY\HTVUxRTBwNDFOwG0> NXfBcnNrOjJ2M{W2Olk>
NCI-ADR-RES NYfkcWc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV22MlIh|ryP MVK3NkBp NHz1Z4RFVVOR NWLPTnRIT0l3ME2wMlE3KM7:TR?= NIXhNmIzOjR|NU[2PS=>
NCI-H23 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoniOk4zKM7:TR?= NUCzN413PzJiaB?= MXzEUXNQ MV;HTVUxRTFizszN NGLXRXkzOjR|NU[2PS=>
NCI-H322M NWD0fIdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XvPVYvOiEQvF2= MX63NkBp Ml2ySG1UVw>? NUnVOVhMT0l3ME2wMlc6KM7:TR?= NVPzfHJbOjJ2M{W2Olk>
NCI-H460 MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHWdII3NjJizszN NHf2TFk4OiCq MUjEUXNQ NISzUJlIUTVyPUCuO|kh|ryP MVWyNlQ{PTZ4OR?=
NCI-H522 NIK1V|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\JNXA3NjJizszN NVXDfmxJPzJiaB?= M1m5VmROW09? MVLHTVUxRTBwNTFOwG0> NWXPbGQ3OjJ2M{W2Olk>
OVCAR3 NVHNRWpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILnVo43NjJizszN NV7VZVVKPzJiaB?= NVTQfYRiTE2VTx?= MkCxS2k2OD1zLkOg{txO MVeyNlQ{PTZ4OR?=
OVCAR4 NIDsZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorMOk4zKM7:TR?= NHH4cWU4OiCq Ml7vSG1UVw>? NXLyS2lqT0l3ME20JO69VQ>? M1;nRVIzPDN3Nk[5
OVCAR5 M3;PR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUO2MlIh|ryP M4jSOFczKGh? MUHEUXNQ NGPkc49IUTVyPUCuO|kh|ryP MkK0NlI1OzV4Nkm=
OVCAR8 NHO3dFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3hOk4zKM7:TR?= NXv0cWhsPzJiaB?= NF25Xm5FVVOR NYXVPXE6T0l3ME2wMlUh|ryP MXiyNlQ{PTZ4OR?=
RXF393 NHrlPIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDwXnA3NjJizszN MWq3NkBp MXzEUXNQ M1\FbGdKPTB;MT6zJO69VQ>? MVKyNlQ{PTZ4OR?=
SF268 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P0UlYvOiEQvF2= MVe3NkBp NXu5fIw3TE2VTx?= NVnSOolHT0l3ME2xMlYh|ryP Mnv6NlI1OzV4Nkm=
SF295 NWfUVZRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrvOk4zKM7:TR?= MWS3NkBp NHLNfoNFVVOR NFLMXHhIUTVyPUGuOkDPxE1? NWDZXWR[OjJ2M{W2Olk>
SF539 M2PLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWS2MlIh|ryP M{LGV|czKGh? M2rvTWROW09? M4nGfWdKPTB;MjFOwG0> MVWyNlQ{PTZ4OR?=
SK-MEL-2 NGHNS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O0fFYvOiEQvF2= M4SzRlczKGh? NV7jZ5U{TE2VTx?= MkjaS2k2OD1zLkOg{txO MYqyNlQ{PTZ4OR?=
SK-MEL-28 Ml3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXnOk4zKM7:TR?= NFfuOYo4OiCq M1r1SmROW09? M37YOGdKPTB;MTFOwG0> NYTZNnplOjJ2M{W2Olk>
SK-MEL-5 MojPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULxclgyPi5{IN88US=> NHu3[W04OiCq NWfqfVJOTE2VTx?= NUD5Sm5RT0l3ME2wMlY{KM7:TR?= NF7zfo8zOjR|NU[2PS=>
SKOV3 NEC5N2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUK2MlIh|ryP M4jJbVczKGh? NYnncVJNTE2VTx?= Mnn0S2k2OD1zIN88US=> NVXybZhFOjJ2M{W2Olk>
SN12C NEDZS5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS5cWY3Pi5{IN88US=> M4jSU|czKGh? MYnEUXNQ MojVS2k2OD1{IN88US=> NVj4cWk1OjJ2M{W2Olk>
SNB19 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonYOk4zKM7:TR?= MUm3NkBp NWC4RZNqTE2VTx?= NFvoR|lIUTVyPUCuOlMh|ryP NV3iNoVOOjJ2M{W2Olk>
SNB75 M1TI[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGzOk4zKM7:TR?= NYfHSI53PzJiaB?= NVvxcWFITE2VTx?= Mk\JS2k2OD1yLke5JO69VQ>? NY\nW2k{OjJ2M{W2Olk>
SR NHPpZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LnN|YvOiEQvF2= MXW3NkBp NIHXUI1FVVOR Mnz2S2k2OD1yLkSg{txO MVOyNlQ{PTZ4OR?=
T47D M{PTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHQdpY3NjJizszN NYHjOZJTPzJiaB?= NFX1bmlFVVOR NInUcWhIUTVyPUCuOUDPxE1? MVeyNlQ{PTZ4OR?=
TK10 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrnRWI{Pi5{IN88US=> NHnPVVQ4OiCq MUTEUXNQ NWO0cHhkT0l3ME2wMlY{KM7:TR?= NH3wOnQzOjR|NU[2PS=>
UACC257 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWzTGNqPi5{IN88US=> NWXMXItyPzJiaB?= NIDuZY1FVVOR NGfiSHVIUTVyPUCuOUDPxE1? M4Lw[|IzPDN3Nk[5
UACC62 MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1niclYvOiEQvF2= NVXJfFRDPzJiaB?= MkjDSG1UVw>? M{P5ZmdKPTB;MD60JO69VQ>? M2\uOlIzPDN3Nk[5
UO31 M{nFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPNOk4zKM7:TR?= M1\OOlczKGh? MkfQSG1UVw>? MUnHTVUxRTBwNTFOwG0> M1;RSVIzPDN3Nk[5
Hep3B NFzKNldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37nRVQ5KGh? MXrEUXNQ NWTDTFR2T0l3ME2wMlY6KM7:TR?= NV;6UIFDOjJ2M{m4OlM>
BE(2)-C NEfJ[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\QW2J1PzJiaB?= Mmi0SG1UVw>? NHPqTFBKSzdyPUKg{txO NFvxeHczOjl|MkOxOi=>
Bel7402 MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzndJA4OiCq MnTLSG1UVw>? MXfHTVkxRTF5IN88US=> Mk\BNlMxPjF|N{[=
Bel7404 Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYm3NkBp MWTEUXNQ NFnHV2NIUTlyPUG4JO69VQ>? NX25Om9[OjNyNkGzO|Y>
BGC823 MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVj1NFhXPzJiaB?= M3XDU2ROW09? Mn;XS2k6OD15LkWg{txO Mo\KNlMxPjF|N{[=
MGC803 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:3NkBp Mm\5SG1UVw>? M4Tm[WdKQTB;MUCuPEDPxE1? M{PUZlI{ODZzM{e2
SGC7901 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jOO|czKGh? NUXH[npkTE2VTx?= MoLtS2k6OD17LkSg{txO NW\4U2JROjNyNkGzO|Y>
SKHEP1 NGX3T5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{noUlczKGh? NFjsfVRFVVOR NW\jfGlKT0l7ME2xO{DPxE1? NVnmdHpoOjNyNkGzO|Y>
SMMC7721 NFrsUnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrwcJZrPzJiaB?= NEjveYNFVVOR MmPZS2k6OD1{MDFOwG0> NXLmb|VMOjNyNkGzO|Y>
NUGC3 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:1OIlHOTBizszN NXe2WFRRT0l;Mj65OEDPxE1? MUmyN|E3OzN|Mh?=
A2780 CisR MlnKT4lv[XOnIFHzd4F6 M1zyOVE5KGh? NV3tUGRxUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlQ1KM7:TR?= MYGyN|I2OjZyMx?=
CAL27 sens MkTYT4lv[XOnIFHzd4F6 M1vCVVE5KGh? M4jyNWlvcGmkaYTpc44hd2ZiSFTBR{B4cXSqIFnDOVAhd2ZiMD6zOkDPxE1? M3zwb|I{OjV{NkCz
CAL27 CisR M4TBU2tqdmG|ZTDBd5NigQ>? M2L5VFE5KGh? Mn;0TY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M1fCXlI{OjV{NkCz
KYSE-510 CisR NF7qcpVMcW6jc3WgRZN{[Xl? NVTYdYt1OThiaB?= NIr3PWVKdmirYnn0bY9vKG:oIFjERWMhf2m2aDDJR|UxKG:oIECuOVkh|ryP Ml;hNlMzPTJ4MEO=
KYSE-510 sens M{HjPWtqdmG|ZTDBd5NigQ>? NHzLVHEyQCCq NVTzTFYyUW6qaXLpeIlwdiCxZjDISGFEKHerdHigTWM2OCCxZjCwMlch|ryP Mlq0NlMzPTJ4MEO=
MDA-MB-231 sens NXfJdIIyU2mwYYPlJGF{e2G7 NFnqRW4yQCCq MoPOTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? M33nRlI{OjV{NkCz
MDA-MB-231 CisR MX;LbY5ie2ViQYPzZZk> NUnJbIpjOThiaB?= MmHFTY5pcWKrdHnvckBw\iCKRFHDJJdqfGhiSVO1NEBw\iByLk[xJO69VQ>? MWSyN|I2OjZyMx?=
ES2 M{jPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[0[2VLPDhiaB?= MnfLSG1UVw>? MlniTWM2OD1zMj63JO69VQ>? NV;rXmY5OjN2OUO0OFk>
MDA-MB-231 MVvLbY5ie2ViQYPzZZk> M3OxUVExKM7:TR?= NF;BZlU{OCCvaX6= M1PTWWROW09? M4HJfGlvcGmkaYTpc44hd2ZiSFTBR|Ji NI\FPIIzOzR7M{S0PS=>
MDA-MB-231 NFzYRnVMcW6jc3WgRZN{[Xl? NVnRdXplOSEQvF2= NVewclMyOjRiaB?= MWTEUXNQ MnntTY5pcWKrdHnvckBw\iCKRFHDOkBie3Onc4Pl[EBieyCjY3X0fYxifGmxbjDs[ZZmdHNib3[geJVjfWyrbh?= MYOyN|Q6OzR2OR?=
HS68 MlT2R5l1d3SxeHnjJGF{e2G7 NGm4VmIyOCEQvF2= NXfNd2tFPzJiaB?= M2DMWWROW09? MWXJR|UxRTRwNjFOwG0> M4DuN|I{PTdyNUSy
MEF M{fCSGN6fG:2b4jpZ{BCe3OjeR?= M3v0TFExKM7:TR?= MlPRO|IhcA>? MWPEUXNQ NYfaRY9HUUN3ME20MlQh|ryP NEjS[VEzOzV5MEW0Ni=>
BGC823 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXFe|BFVVOR MVzHTVUxRTNwMEmg{txO MWGyN|YxOTdyNh?=
High5 MlOxT4lv[XOnIFHzd4F6 NHHZW5QzPCCq MYPJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVO2JJdqfGhiSVO1NEBw\iByLkC5JO69VQ>? MX6yN|YxOjV{Mx?=
High5 MoG3T4lv[XOnIFHzd4F6 M1T0ZlI1KGh? NH\L[4JKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IFjERWMyKHerdHigTWM2OCCxZjCwMlEzKM7:TR?= M4TaZ|I{PjB{NUKz
High5 MXfLbY5ie2ViQYPzZZk> M{fYN|I1KGh? MUfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KEiGQVOzJJdqfGhiSVO1NEBw\iByLkG3JO69VQ>? MYmyN|YxOjV{Mx?=
A549 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfXSG1UVw>? M1qzV2lEPTB;MT6wO|kh|ryP NIDT[ZEzOzZ2NEKxNC=>
HCT116 M{\nW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKzUFdWTE2VTx?= NUTMUHF4UUN3ME2wMlc2PyEQvF2= NFvp[XEzOzZ2NEKxNC=>
K562 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW5SG1UVw>? MYDJR|UxRTBwNkS1JO69VQ>? MUeyN|Y1PDJzMB?=
GBC-SD Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:2TXg2KM7:TR?= MXq3NkBp NGjuTmxFVVOR M2HUbWlEPTB;MUSuPEDPxE1? NFHNdIozOzdyN{K2NC=>
HGC27 NWnDPZVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHpNphoPSEQvF2= MV[3NkBp M2PYO2ROW09? NF7NWoxKSzVyPUWuOEDPxE1? Mn7ONlM4ODd{NkC=
HL60 M1\S[2tqdmG|ZTDBd5NigQ>? MkDTOUDPxE1? M1ux[VI1KGh? NYTLTopOTE2VTx?= M3PVd2lvcGmkaYTpc44hd2ZiSFTBRy=> NU\0RYd3OjN5MEeyOlA>
Vero MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULmXXpFPzJiaB?= MX7EUXNQ Mo\4TWM2OD1yLkmg{txO NX\JXGdbOjN5OE[0OVI>
NCI60 MkTwR5l1d3SxeHnjJGF{e2G7 NGHmbI01QCCq MkXWSG1UVw>? M3;PTmdKRTBwNUOg{txO M2C3WFI1ODF3M{K3
SW620 MnezR5l1d3SxeHnjJGF{e2G7 NWjPcGx{PDhiaB?= MlvSSG1UVw>? NX;xZ41RT0l;MD61OEDPxE1? NFLrPWwzPDBzNUOyOy=>
U251 NIDMR2tEgXSxdH;4bYMhSXO|YYm= NUD4PFRwPDhiaB?= MoH5SG1UVw>? NG\je4dIUT1zLkWzJO69VQ>? MYSyOFAyPTN{Nx?=
KM12 Mmq2R5l1d3SxeHnjJGF{e2G7 NVX4UmZMPDhiaB?= NXTsSFRNTE2VTx?= MmmxS2k:OS56ODFOwG0> MVyyOFAyPTN{Nx?=
Hs578T MVrDfZRwfG:6aXOgRZN{[Xl? MXu0PEBp MlL6SG1UVw>? MnThS2k:PC56MzFOwG0> M2TPRlI1ODF3M{K3
MDA-MB-231 NI\hcVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzZPZk1QCCq NUOwPZBnUUN3ME2wMlE3KM7:TR?= NH7yfW4zPDB7NUCxOi=>
MCF7 NV7VbJFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG0PEBp NIXnV4VIUT1yLkS1JO69VQ>? M1zrSlI1OTF7NUW1
MDA-MB-435 NGPXUnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DsXlQ5KGh? NYi2XW1yT0l;MD64PEDPxE1? NIHSdoIzPDFzOUW1OS=>
AsPC1 Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUSzNEDPxE1? M12x[FQ5KGh? MnHHSG1UVw>? M37Y[mlEPTB;Mz62OkDPxE1? NFzNenAzPDF6NUO3PC=>
Jurkat E6.1 MYHLbY5ie2ViQYPzZZk> NXrUUop3OiCq M{KxU2ROW09? NITqZ|ZKdmirYnn0bY9vKG:oIFjERWM1KHerdHigTWM2OCCxZjCwMlA1KM7:TR?= NUnHcHo{OjR{NkG4OlI>
KG1 NELXXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TzcFQ5KGh? MWrJR|UxRTFwMUWg{txO NVLDWWNtOjR3MkWwNFM>
HEL MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTqcHQ1QCCq MknoSG1UVw>? M{\lTmlEPTB;MD60PUDPxE1? NIf5ZoIzPDZ7NEC1OS=>
HSC3 NVnsTGw4S3m2b4TvfIlkKEG|c3H5 MmPrNVIhcA>? MnfsSG1UVw>? M3zW[2lEPTB;MD63NUDPxE1? MoG2NlQ4PjZ3NkC=
HT-29 MmfQR5l1d3SxeHnjJGF{e2G7 MWixNkBp MYDEUXNQ NWfqSpNyUUN3ME2wMlczKM7:TR?= NV3UXYZXOjR5Nk[1OlA>
KB MU\DfZRwfG:6aXOgRZN{[Xl? MUCxNkBp M2PCVmROW09? NFzvW29KSzVyPUCuO|Uh|ryP M3vhb|I1PzZ4NU[w
H460 NWLhV5RNS3m2b4TvfIlkKEG|c3H5 NX\NT5dSOTJiaB?= M3jkWmROW09? M3;kcGlEPTB;MD64NkDPxE1? M1HqcVI1PzZ4NU[w
MONE1 NEDMUlREgXSxdH;4bYMhSXO|YYm= MnzFNVIhcA>? NUi3WJJxTE2VTx?= Mnf1TWM2OD1zLkG4JO69VQ>? NV\jR4hTOjR5Nk[1OlA>
MKN45 NUnjcWNES3m2b4TvfIlkKEG|c3H5 MYixNkBp MojBSG1UVw>? MkL6TWM2OD1zLkK1JO69VQ>? MWWyOFc3PjV4MB?=
TSGH Mn73R5l1d3SxeHnjJGF{e2G7 M3PZOFEzKGh? M1e5TmROW09? MXHJR|UxRTJwMEmg{txO NGW2cGczPDd4NkW2NC=>
HL60 M2rSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfkeG44OiCq MmXBSG1UVw>? NX3XcYZVT0l3ME2wMlk{KM7:TR?= NYi5XpVxOjR7MEC1NFA>
HEK293 NWTMT2VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUC3NkBp NXP6ZpBiTE2VTx?= NUO2SGtXT0l3ME2xN{DPxE1? Mof3NlQ6ODB3MEC=
Jurkat MmTNR5l1d3SxeHnjJGF{e2G7 NYe2eHNtOTByIN88US=> NXj3XpdEPzJiaB?= M1y0SmdKPTB;MD65JO69VQ>? MUOyOFkxODd2Mx?=
GM15850 NIjjdFFMcW6jc3WgRZN{[Xl? MlPjNk42KM7:TR?= MU[5OkBp MmntSG1UVw>? M33Cb4Rw\XNibn;0JIlvcGmkaYSgTGRCSyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBpcXO2b37lJGg{KGy7c3nu[UAyPCCjY3X0fYxifGmxbjDv[kBHYE5iZ3Xu[S=> MXmxOlkzOTN4Nx?=
GM15850 MXfLbY5ie2ViQYPzZZk> MojuNk42KM7:TR?= NYXP[YVRQTZiaB?= NY\OR5ZLTE2VTx?= MoTk[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFQhdHm|aX7lJFUh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NIizNnIyPjl{MUO2Oy=>
GM15850 MoLrT4lv[XOnIFHzd4F6 Mon2Nk42KM7:TR?= MoHiPVYhcA>? NXjRd3ZxTE2VTx?= MXfkc4V{KG6xdDDpcohq[mm2IFjERWMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbIl{fG:wZTDIOEBtgXOrbnWgNVIh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NELRbWIyPjl{MUO2Oy=>
GM15850 NGnwU|lMcW6jc3WgRZN{[Xl? NUO1dmZqOi53IN88US=> Mnr3PVYhcA>? M2PufGROW09? MoLl[I9meyCwb4SgbY5pcWKrdDDISGFEKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIhqe3SxbnWgTFMhdHm|aX7lJFkh[WOndInsZZRqd25ib3[gSnhPKGenbnW= NXftV4h7OTZ7MkGzOlc>
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NCI-H1048 NX7ZVWU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnaTIxVUUN3ME2yMlU2ODJ3IN88US=> NVHhcHRKW0GQR1XS
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COR-L23 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO0SmY3UUN3ME2yMlU5PTZ4IN88US=> NIf3O4pUSU6JRWK=
MKN28 NHOycJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWntbndVUUN3ME2yMlU6ODN5IN88US=> NEH1bpRUSU6JRWK=
22RV1 NX[4OJJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHtbGExUUN3ME2yMlU6Ojd2IN88US=> MYTTRW5ITVJ?
ABC-1 NU\RPYhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLxUpBKSzVyPUKuOlA1PiEQvF2= NVT5TZRYW0GQR1XS
NCI-H2126 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPDTWM2OD1{Lk[wPVg1KM7:TR?= M2O4[nNCVkeHUh?=
DoTc2-4510 NHLRU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPoUGw{UUN3ME2yMlYzOTh3IN88US=> NE\LSphUSU6JRWK=
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NCI-H510A MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwNkS0NlYh|ryP Mle5V2FPT0WU
BPH-1 NHP2UJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLaUmNKSzVyPUKuOlU5PSEQvF2= MkDlV2FPT0WU
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NB12 MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HRWmlEPTB;Mj63NVcyKM7:TR?= NVzidJM4W0GQR1XS
SK-HEP-1 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTRTlRKSzVyPUKuO|Q{QTFizszN M{XVNHNCVkeHUh?=
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AM-38 NF\MR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rsOGlEPTB;Mj63O|M2PSEQvF2= MY\TRW5ITVJ?
PC-14 M3nIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJwOEC1NUDPxE1? MlrpV2FPT0WU
EGI-1 NVKwUHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7ySnZKSzVyPUKuPFE4PDNizszN NFu0cG5USU6JRWK=
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BFTC-905 MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTJwOEW1NlMh|ryP Mn6zV2FPT0WU
CaR-1 MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvvfFV2UUN3ME2yMlg3KM7:TR?= NF7Cd45USU6JRWK=
NCI-H292 NVH4WI5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;pb3dKSzVyPUKuPFY2QTZizszN NXGwfIp5W0GQR1XS
8305C NHLDPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJwOE[2OFUh|ryP MXPTRW5ITVJ?
SNU-449 NUHLbm46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXhTWM2OD1{Lki5NVgzKM7:TR?= MmntV2FPT0WU
LCLC-103H NGPLOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwOUC0N|gh|ryP NYTsblN1W0GQR1XS
SW1573 MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXuTYxKSzVyPUKuPVYxQDJizszN NGmwUI5USU6JRWK=
MLMA M4fkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLpTWM2OD1{Lkm2O|E4KM7:TR?= M1XWXnNCVkeHUh?=
NCI-H1355 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf1VYdDUUN3ME2zMlAxPzl4IN88US=> M174cHNCVkeHUh?=
RMG-I M1[2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTNwMEK1PVIh|ryP NHz3[|JUSU6JRWK=
BB65-RCC M3vlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjiT|RKSzVyPUOuNFM{OTRizszN MYXTRW5ITVJ?
PC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjHbZR{UUN3ME2zMlA{QDd2IN88US=> NVqyZVlUW0GQR1XS
SF268 M4rNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTNwMES1NlMh|ryP NEe0bmVUSU6JRWK=
NCI-H810 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXqSndYUUN3ME2zMlA1QDJ|IN88US=> Mo\GV2FPT0WU
MEG-01 M1HNS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3G1TWlEPTB;Mz6wOlE3PCEQvF2= NHPoZpBUSU6JRWK=
SW13 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ywd2lEPTB;Mz6wO|g1PyEQvF2= MXLTRW5ITVJ?
RH-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTNwMUCyO|gh|ryP NGryPVhUSU6JRWK=
GT3TKB MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vvXmlEPTB;Mz6xNVI5OyEQvF2= M{WzZXNCVkeHUh?=
TK10 NGfK[pBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTNwMUO3NlQh|ryP MVPTRW5ITVJ?
T-24 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTNwMUWwO{DPxE1? M3WxSnNCVkeHUh?=
A498 MneyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjQTWM2OD1|LkKwPFcyKM7:TR?= MlryV2FPT0WU
GR-ST MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\STWM2OD1|LkKyNVM6KM7:TR?= NX7tUJREW0GQR1XS
LB2518-MEL NEjSdYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzYXVdKSzVyPUOuNlI{QThizszN NVrFS4ViW0GQR1XS
T47D M4Dpemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTNwMkO2Nlch|ryP Mlv6V2FPT0WU
NCI-H1651 MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\DOWlEPTB;Mz6yOFY1PCEQvF2= M2PB[nNCVkeHUh?=
EC-GI-10 MnzJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\Ve25CUUN3ME2zMlI3OTV|IN88US=> NVfrRZloW0GQR1XS
HT-29 NYLXT457T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTNwMk[2NVQh|ryP M3HHR3NCVkeHUh?=
GI-ME-N NVzNOoliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK1TWM2OD1|LkK5OVEyKM7:TR?= MnfkV2FPT0WU
SW756 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLHTWM2OD1|LkK5OlI6KM7:TR?= MmTxV2FPT0WU
RKO MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\3bGlEPTB;Mz6zNFc2PyEQvF2= NI\4VGVUSU6JRWK=
NCI-H1563 M{fGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnROYxKSzVyPUOuN|MxOThizszN M2rFOnNCVkeHUh?=
DJM-1 NVi2RWdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmwOlJKSzVyPUOuN|c3PzRizszN M4XofXNCVkeHUh?=
L-428 NYLpTFJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfneWVGUUN3ME2zMlQxODR3IN88US=> Mn2wV2FPT0WU
NCI-H2122 NXX0fmVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvFc3NoUUN3ME2zMlQyOzF{IN88US=> NHviZlVUSU6JRWK=
Ca-Ski MmDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTNwNEW0N{DPxE1? NED6[VNUSU6JRWK=
639-V Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\zTWM2OD1|LkS2NFU4KM7:TR?= NF[5ZY5USU6JRWK=
SW1116 M3;qPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr6TWM2OD1|LkS2NlY6KM7:TR?= M2fiXXNCVkeHUh?=
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MZ2-MEL MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nSemlEPTB;Mz60O|Y5OSEQvF2= MYnTRW5ITVJ?
COLO-829 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jPR2lEPTB;Mz61NFA4OyEQvF2= NXvYfXMyW0GQR1XS
J82 MlnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTNwNUC1O{DPxE1? MlzBV2FPT0WU
EW-13 M{TKTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvoTWM2OD1|LkWyOVEh|ryP NWL4T2t3W0GQR1XS
RXF393 NVT5NI85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrS[XFxUUN3ME2zMlU{Ojl2IN88US=> MmXFV2FPT0WU
CAL-62 MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDBTWM2OD1|LkW0OVE1KM7:TR?= MXHTRW5ITVJ?
OCUB-M MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXWc|dnUUN3ME2zMlU1PjZ3IN88US=> NX\xbGlyW0GQR1XS
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KYSE-180 M{ewN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPS[lZ5UUN3ME2zMlY{Ozd{IN88US=> NU\YNHBJW0GQR1XS
NCI-H650 M33uNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfwTWM2OD1|Lk[0Nlg4KM7:TR?= M{\1UnNCVkeHUh?=
Detroit562 M3zUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTNwNkWwNlIh|ryP NX;I[mpDW0GQR1XS
SW48 NIK2N2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLIUVZzUUN3ME2zMlY2PjV5IN88US=> NFjZNXZUSU6JRWK=
KYSE-450 Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXBWVBKSzVyPUOuOlg2QDJizszN MX3TRW5ITVJ?
KYSE-510 NH;kW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzsOZBKSzVyPUOuO|IyQDFizszN M2[ycHNCVkeHUh?=
GP5d NF\RNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvjS3h1UUN3ME2zMlczQTVizszN MXvTRW5ITVJ?
RPMI-7951 MnPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvIRpdHUUN3ME2zMlc1PzJ|IN88US=> MonCV2FPT0WU
Becker M2\Pemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTMTWM2OD1|Lke1NFEzKM7:TR?= MXrTRW5ITVJ?
WM-115 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPITWM2OD1|Lke4NVk2KM7:TR?= NYqwVXVKW0GQR1XS
G-401 NV62ZYpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPGTWM2OD1|Lke5NFg2KM7:TR?= NVnpNYlyW0GQR1XS
PANC-08-13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z5eGlEPTB;Mz63PVYxOiEQvF2= NVz5VmtNW0GQR1XS
SW982 NX3Id2ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTNwOEC1OVEh|ryP M2KyTHNCVkeHUh?=
D-263MG NGfZVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3STWM2OD1|LkiyNFUyKM7:TR?= MojLV2FPT0WU
KM-H2 M{T0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHkTWM2OD1|LkiyOlI1KM7:TR?= MWPTRW5ITVJ?
SK-MEL-3 M2HwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyxW3VRUUN3ME2zMlgzQDRzIN88US=> NX\selJoW0GQR1XS
NCI-H1581 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3oTWM2OD1|Lki0OFg5KM7:TR?= M{faRnNCVkeHUh?=
LS-123 MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUj5XoM3UUN3ME2zMlg4QTB7IN88US=> MX\TRW5ITVJ?
CAKI-1 M1r0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHhTWM2OD1|Lki5NFUzKM7:TR?= MUXTRW5ITVJ?
MEL-JUSO NY\XPYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvpemJKSzVyPUOuPFkyPTNizszN NIC0TnpUSU6JRWK=
HCE-4 NFjBSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTYOJV4UUN3ME2zMlkyPjZ|IN88US=> NGf5NnNUSU6JRWK=
TE-10 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PFTGlEPTB;Mz65NlAyKM7:TR?= NWjDeYc2W0GQR1XS
OVCAR-4 M1fKWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;nTWM2OD1|LkmyPFg6KM7:TR?= NFPUTYVUSU6JRWK=
ETK-1 NUXue45PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK2RpZTUUN3ME2zMlk1PjN3IN88US=> Mo\QV2FPT0WU
A2780 M{nvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLsWG1KSzVyPUSuNFU6PjZizszN MnjoV2FPT0WU
LU-65 NHLje5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTRwMEe2N|Mh|ryP NYDsOpV[W0GQR1XS
BHY MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfCS4l[UUN3ME20MlEzPDl3IN88US=> NVmwc3JuW0GQR1XS
COR-L105 M2fwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jhdGlEPTB;ND6xN|A2OSEQvF2= M3LRUHNCVkeHUh?=
CAL-12T MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTuVY11UUN3ME20MlE{OTB|IN88US=> MYjTRW5ITVJ?
SCH Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;wcZM6UUN3ME20MlE2PzR|IN88US=> NVL0UlBsW0GQR1XS
CW-2 NF;DZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T5c2lEPTB;ND6xPVAxOSEQvF2= NHnYRXBUSU6JRWK=
HCC1806 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTUVFFlUUN3ME20MlIxOzF{IN88US=> NITGb4VUSU6JRWK=
KP-N-YN Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jySGlEPTB;ND6yNFkzPyEQvF2= M3H1W3NCVkeHUh?=
T98G NX7PZ2x4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofyTWM2OD12LkKyNVU4KM7:TR?= M3G0fHNCVkeHUh?=
CAL-54 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXsOZVmUUN3ME20MlIzOzhzIN88US=> NFnNTHZUSU6JRWK=
CAL-33 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK5OIRVUUN3ME20MlI{ODZ2IN88US=> MlmzV2FPT0WU
SNU-C2B NVvnU4ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTRwMkS3Olkh|ryP NX;LeHBVW0GQR1XS
NUGC-3 MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DRRWlEPTB;ND6yOVUxPSEQvF2= NYTvSG1wW0GQR1XS
DOK NH3U[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TSZ2lEPTB;ND6yOlU6OyEQvF2= MonDV2FPT0WU
MMAC-SF NIHCWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrpbmVKSzVyPUSuNlY5PTlizszN NGD6RWxUSU6JRWK=
KYSE-70 NFHtc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3seJg2UUN3ME20MlI6OzRizszN NUPifYhtW0GQR1XS
A204 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRwM{W4NFMh|ryP NFXTeWJUSU6JRWK=
SCC-25 MlfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TpeGlEPTB;ND6zOVgyQSEQvF2= NGLqUFJUSU6JRWK=
EPLC-272H NEjLNVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;vfWlEPTB;ND6zPFk2KM7:TR?= NEn4UJdUSU6JRWK=
CAL-120 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTRwM{i5PVIh|ryP NHHxbnVUSU6JRWK=
LS-513 NF76eZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m3VWlEPTB;ND60NlE6QCEQvF2= NXrVO4NKW0GQR1XS
CAPAN-1 NH2wZ|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFviZmlKSzVyPUSuOFI{QDJizszN M1XNN3NCVkeHUh?=
ESS-1 M3LNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDPVoZKSzVyPUSuOFI4OjRizszN NXLrPYxoW0GQR1XS
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SK-MEL-28 NIW3VYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX2WlZKSzVyPUGwMlAyQTNizszN M1LNVXNCVkeHUh?=
NCI-H2452 M4D4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3JNI1CUUN3ME2xNE4yPiEQvF2= MXnTRW5ITVJ?
NCI-H1395 NITiZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPTS3JnUUN3ME2xNE4yPzhizszN MkGwV2FPT0WU
NCI-H2052 NWfkRWZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvyNFdTUUN3ME2xNE4yQDh{IN88US=> M2PXdXNCVkeHUh?=
A375 MoXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTFyLkK0OVIh|ryP MXjTRW5ITVJ?
HCC38 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPCVVNSUUN3ME2xNE4{OjJizszN NUDOWFZkW0GQR1XS
LK-2 M{jvTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjWTWM2OD1zMD60NlA5KM7:TR?= NY\hTGdUW0GQR1XS
SF126 M3XPd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEn2PW9KSzVyPUGwMlQ4OjdizszN MWPTRW5ITVJ?
SK-MEL-1 NYTGbY54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHSTWM2OD1zMD63PFM5KM7:TR?= MlfSV2FPT0WU
ACN MlH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\COmlEPTB;MUCuPFY4QSEQvF2= NHXGV|hUSU6JRWK=
BB30-HNC NHX4[HFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFyLki3NVEh|ryP MVHTRW5ITVJ?
NCI-H747 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFyLki3OFYh|ryP MnXqV2FPT0WU
KYSE-150 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLINZUzUUN3ME2xNU4xOzh5IN88US=> NUTmUnVRW0GQR1XS
D-247MG NX;rT4JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDkTVhKSzVyPUGxMlExODlizszN MmTVV2FPT0WU
BxPC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDsbWJsUUN3ME2xNU4{PzR5IN88US=> M1XXWHNCVkeHUh?=
SK-MEL-30 M33QfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPVTWM2OD1zMT60NFc6KM7:TR?= MlK3V2FPT0WU
CAS-1 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rmN2lEPTB;MUGuOFExQSEQvF2= MlrXV2FPT0WU
no-10 NYLyTlBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzEcllKSzVyPUGyMlEzOTdizszN MUDTRW5ITVJ?
NCI-H2405 M3\tdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLETWM2OD1zMj6yNFM3KM7:TR?= MWrTRW5ITVJ?
KGN NHztTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS2TWM2OD1zMj6yPVAyKM7:TR?= MVvTRW5ITVJ?
BB49-HNC M1:wR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTKTWM2OD1zMj6zPVU3KM7:TR?= MkHSV2FPT0WU
NCI-H1693 MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LPc2lEPTB;MUKuOVgyPiEQvF2= MmfEV2FPT0WU
RO82-W-1 NF;5N3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPzTWM2OD1zMz6wOlQ6KM7:TR?= NYXNUZJoW0GQR1XS
CAL-85-1 NUHURpFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTF|LkSzPVkh|ryP MlXpV2FPT0WU
H-EMC-SS NWXDWIdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPkTWM2OD1zMz65NVA1KM7:TR?= MniwV2FPT0WU
SW1783 MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF2LkKzPVEh|ryP NY\jWpN4W0GQR1XS
LB771-HNC MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF2LkSxPUDPxE1? MYDTRW5ITVJ?
HCC70 NF3WWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki5TWM2OD1zND60NlM{KM7:TR?= M4\VOXNCVkeHUh?=
KNS-81-FD MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLOTWM2OD1zND63NFQ2KM7:TR?= Moq3V2FPT0WU
KYSE-520 M4S0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLHTWM2OD1zND65Nlch|ryP MXHTRW5ITVJ?
TGBC24TKB NHfDRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17MUmlEPTB;MUSuPVU{QSEQvF2= MYjTRW5ITVJ?
SNB75 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPqTWM2OD1zNT6wO|I6KM7:TR?= M1rvXnNCVkeHUh?=
SW872 NW\FXGxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLOPVJHUUN3ME2xOU4zOjF6IN88US=> NYXycYpnW0GQR1XS
U031 M33aSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ewSGlEPTB;MUWuPFAzQCEQvF2= MoTQV2FPT0WU
ChaGo-K-1 NIHpNlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD3WFY1UUN3ME2xOU45OzV7IN88US=> MoHPV2FPT0WU
NCI-H441 NGf4dXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIG0RoRKSzVyPUG2MlAxOzlizszN MnPGV2FPT0WU
TE-12 NXrieY01T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\sTWM2OD1zNj6xPFc{KM7:TR?= MkHOV2FPT0WU
NCI-H1755 NIS1WINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXQTWM2OD1zNj61O|Mh|ryP MUnTRW5ITVJ?
KNS-42 NY\JemN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfYPYtKSzVyPUG2MlY2QDlizszN MkXKV2FPT0WU
SK-PN-DW NVTzNHRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHOW3NtUUN3ME2xO{41OjBzIN88US=> M37RfHNCVkeHUh?=
NCI-H226 NVrDXVRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV36XFdTUUN3ME2xO{46OzR3IN88US=> MXLTRW5ITVJ?
K-562 M33kO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHIT4ZKSzVyPUG4MlY{OTdizszN MXXTRW5ITVJ?
A388 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DXdmlEPTB;MUmuNFMxOyEQvF2= M2DCZnNCVkeHUh?=
ZR-75-30 Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnYS|BTUUN3ME2xPU4xQTZ6IN88US=> M2f0ZXNCVkeHUh?=
LU-135 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\2TWM2OD1zOT6yOlM3KM7:TR?= Ml;LV2FPT0WU
NCI-H2029 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTF7Lk[wNlEh|ryP NGHt[HRUSU6JRWK=
HT-1197 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPGTWM2OD1zOT65NlI4KM7:TR?= MXrTRW5ITVJ?
IGR-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrucnhvUUN3ME2yNE4{OTF5IN88US=> NIS3O3RUSU6JRWK=
U-87-MG NHrhZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTC[nQ4UUN3ME2yNE43PDF|IN88US=> NFHReGxUSU6JRWK=
NCI-H1304 M33zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTJyLke1NFEh|ryP Mnr3V2FPT0WU
RCC10RGB M2DVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHiZm1KSzVyPUKxMlI5OjlizszN M1vkenNCVkeHUh?=
NCI-H520 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3rdY5JUUN3ME2yNk44PjFzIN88US=> MlLjV2FPT0WU
SK-LU-1 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL5dGhKSzVyPUKzMlA4OThizszN M{\qNnNCVkeHUh?=
UACC-893 NWjhbWdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTNV2ZKSzVyPUKzMlExOzhizszN MUXTRW5ITVJ?
NCI-H2347 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJ|LkK2O|Qh|ryP MUPTRW5ITVJ?
U-118-MG MkPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ|LkeyNVch|ryP MWnTRW5ITVJ?
NCI-H596 NIWzOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nneWlEPTB;MkOuPVA2PSEQvF2= MXvTRW5ITVJ?
MZ1-PC M3\HRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nmRmlEPTB;MkSuOlc2QSEQvF2= MYrTRW5ITVJ?
SW1417 NV;3fWc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PVTmlEPTB;MkWuNlQ6QCEQvF2= MlzxV2FPT0WU
NCI-H82 NYLyR4ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\kWodbUUN3ME2yOk41Ojh6IN88US=> MV;TRW5ITVJ?
COLO-678 NFrUNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvFd4pKSzVyPUK3MlQ6OTlizszN NVvkZoloW0GQR1XS
KURAMOCHI NHLW[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPNblRZUUN3ME2yPE4yOjZizszN M3nmO3NCVkeHUh?=
NCI-H1650 NX\WdZk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXoeW5KSzVyPUOwMlE6OjRizszN MXHTRW5ITVJ?
HCC1954 MmPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TjUGlEPTB;M{GuN|Y3PiEQvF2= Ml3xV2FPT0WU
GAK MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLOTWM2OD1|Mj6yOlE3KM7:TR?= MUXTRW5ITVJ?
YAPC NX22O|lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fFXmlEPTB;M{OuO|Y1QCEQvF2= NFLMSYZUSU6JRWK=
NCI-H2228 NEOwe4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jDS2lEPTB;M{SuN|YxPSEQvF2= NX3JdplqW0GQR1XS
VMRC-RCZ MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm3cYZ6UUN3ME2zOk4{ODJ{IN88US=> Ml;sV2FPT0WU
NMC-G1 NFTkc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHvbnNKSzVyPUO3MlA2OjlizszN MXvTRW5ITVJ?
D-336MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTRzLki0OFIh|ryP MULTRW5ITVJ?
UACC-62 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHlSJZKSzVyPUSyMlU2ODVizszN NHvFS2RUSU6JRWK=
C-33-A MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[3TWM2OD12NT6zNlU3KM7:TR?= NVjOWnk3W0GQR1XS
HCC1937 M2jlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFizN|FKSzVyPUS3MlE6PThizszN MU\TRW5ITVJ?
HDLM-2 NXrWWWN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDiemJtUUN3ME20O{4zOjh5IN88US=> NVTxZ|NZW0GQR1XS
NCI-H727 NELRNnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGzNXFsUUN3ME20O{4zPDVzIN88US=> NGrMXnJUSU6JRWK=
NY M3T2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qyO2lEPTB;NEmuN|kxQCEQvF2= NWTmfYdiW0GQR1XS
NCI-H2291 NE\kO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LKc2lEPTB;NEmuPFMxOSEQvF2= MofHV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Administration of Vorinostat (~100 mg/kg/day) significantly inhibits the growth of CWR22 human prostate xenografts in nude mice with tumor reductions of 78%, 97% and 97%, at doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively, compared with control. Vorinostat induces the accumulation of acetylated core histones and prostate-specific antigen mRNA expression in CWR22 cells, resulting in higher levels of serum prostate-specific antigen than predicted from tumor volume alone. [2] Oral administration of Vorinostat (0.67g/L) crosses the blood-brain barrier, increases histone acetylation in the brain, and dramatically improves the motor impairment in the R6/2 mice model of Huntington's disease. [5]

Protocol

Kinase Assay:

[1]

+ Expand

Immunoprecipitation-HDAC assays:

The lysate of Jurkat cells is incubated for 1 hour on ice and cleared by centrifugation at 12,000 g for 10 minutes at 4 °C. Supernatants are precleared with 30 μL of 50% protein G-Sepharose slurry for 1 hour at 4 °C. Beads are pelleted by centrifugation and supernatants are incubated for 1 hour at 4 °C with 10 μg of IgG fraction from anti-HDAC1 or HDAC3 polyclonal antisera (preincubated 2 hours at room temperature with either the homologous or heterologous immunizing peptide). Both antisera are raised in rabbits against the carboxylterminal peptide of HDAC1 and HDAC3 by using synthetic peptides coupled to keyhole limpet hemocyanin. 30 μL of 50% protein G-Sepharose slurry is added for 1 hour at 4 °C. Immune complexes are pelleted by centrifugation and washed three times with 1 mL of lysis buffer. Beads are resuspended in 200 μL of HDAC buffer (20 mM Tris-HCl, pH 8.0/150 mM NaCl/10% glycerol), and the HDAC assay is performed with an 3H-acetylated peptide corresponding to amino acids 1-24 of histone H4. Released [3H]acetic acid is quantified by scintillation counting. For inhibitions studies, the immunoprecipitated complexes are preincubated with the different concentrations of Vorinostat for 30 minutes at 4 °C.
Cell Research:

[2]

+ Expand
  • Cell lines: LNCaP, PC-3, and TSU-Pr1
  • Concentrations: Dissolved in DMSO, final concentrations ~7.5 μM
  • Incubation Time: 1, 2, 3 and 4 days
  • Method:

    Cells are exposed to various concentrations of Vorinostat for 1, 2, 3 and 4 days. Cell viability is assessed by trypan blue dye exclusion.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Male BALB/c nude (nu/nu) mice implanted with CWR22 tumor cells
  • Formulation: Dissolved in DMSO
  • Dosages: ~100 mg/kg/day
  • Administration: Injection i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 52 mg/mL (196.74 mM)
Ethanol 3 mg/mL (11.35 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 264.3
Formula

C14H20N2O3

CAS No. 149647-78-9
Storage powder
in solvent
Synonyms SAHA, MK0683, suberoylanilide hydroxamic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03742245 Not yet recruiting Breast Cancer Metastatic|Breast Cancer Jenny C. Chang MD|AstraZeneca|The Methodist Hospital System March 1 2019 Phase 1
NCT03022565 Recruiting Uveal Melanoma University of Miami|University of Miami Sylvester Comprehensive Cancer Center December 2018 Early Phase 1
NCT03263533 Recruiting Schizophrenia Virginia Commonwealth University December 1 2018 Early Phase 1
NCT03259503 Not yet recruiting Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic|Lymphoma M.D. Anderson Cancer Center|AstraZeneca November 2018 Phase 1|Phase 2
NCT03713320 Recruiting Cutaneous T-Cell Lymphoma/Mycosis Fungoides miRagen Therapeutics Inc. October 2018 Phase 2
NCT03382834 Active not recruiting HIV Infections National Institute of Allergy and Infectious Diseases (NIAID) April 26 2018 Early Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    We recommend the following vehicle for S1047: 2% DMSO, 40% PEG 300, 5% Propylene glycol, 1% Tween 80 at 5 mg/mL.

HDAC Signaling Pathway Map

HDAC Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID