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BI-D1870

Name: BI-D1870
Brand: Selleck Chemicals
SKU: S2843
Rating: 5 (56 reviews)

Catalog No.S2843 Purity:99.75%

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

BI-D1870 Chemical Structure

CAS No. 501437-28-1

Purity & Quality Control

Batch: Purity: 99.75%

99.75

BI-D1870 Related Products

Related Targets	p70 S6K p70 S6K1 RSK1 RSK2 RSK3 RSK4	Click to Expand
Related Products	PF-4708671 LY2584702 LY2584702 Tosylate LJI308 LJH685	Click to Expand
Related Compound Libraries	Kinase Inhibitor Library PI3K/Akt Inhibitor Library Apoptosis Compound Library Cell Cycle compound library NF-κB Signaling Compound Library	Click to Expand

Signaling Pathway

S6 Kinase Signaling Pathway

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	Growth Inhibition Assay	Inhibition of human EW-3 cell growth in a cell viability assay, IC50 = 0.0358 μM.	SANGER
H9	Growth Inhibition Assay	Inhibition of human H9 cell growth in a cell viability assay, IC50 = 0.06019 μM.	SANGER
KARPAS-45	Growth Inhibition Assay	Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50 = 0.16525 μM.	SANGER
NCI-H720	Growth Inhibition Assay	Inhibition of human NCI-H720 cell growth in a cell viability assay, IC50 = 0.17194 μM.	SANGER
CTV-1	Growth Inhibition Assay	Inhibition of human CTV-1 cell growth in a cell viability assay, IC50 = 0.47872 μM.	SANGER
DU-4475	Growth Inhibition Assay	Inhibition of human DU-4475 cell growth in a cell viability assay, IC50 = 0.50417 μM.	SANGER
A172	Growth Inhibition Assay	Inhibition of human A172 cell growth in a cell viability assay, IC50 = 0.51705 μM.	SANGER
EW-18	Growth Inhibition Assay	Inhibition of human EW-18 cell growth in a cell viability assay, IC50 = 0.62211 μM.	SANGER
KU812	Growth Inhibition Assay	Inhibition of human KU812 cell growth in a cell viability assay, IC50 = 0.62623 μM.	SANGER
KP-N-YS	Growth Inhibition Assay	Inhibition of human KP-N-YS cell growth in a cell viability assay, IC50 = 0.68223 μM.	SANGER
SBC-1	Growth Inhibition Assay	Inhibition of human SBC-1 cell growth in a cell viability assay, IC50 = 0.69524 μM.	SANGER
ECC10	Growth Inhibition Assay	Inhibition of human ECC10 cell growth in a cell viability assay, IC50 = 0.70094 μM.	SANGER
GAMG	Growth Inhibition Assay	Inhibition of human GAMG cell growth in a cell viability assay, IC50 = 0.74717 μM.	SANGER
NCI-H209	Growth Inhibition Assay	Inhibition of human NCI-H209 cell growth in a cell viability assay, IC50 = 0.7682 μM.	SANGER
MC-IXC	Growth Inhibition Assay	Inhibition of human MC-IXC cell growth in a cell viability assay, IC50 = 0.79589 μM.	SANGER
HSC-3	Growth Inhibition Assay	Inhibition of human HSC-3 cell growth in a cell viability assay, IC50 = 0.81769 μM.	SANGER
IST-SL1	Growth Inhibition Assay	Inhibition of human IST-SL1 cell growth in a cell viability assay, IC50 = 0.84574 μM.	SANGER
LU-139	Growth Inhibition Assay	Inhibition of human LU-139 cell growth in a cell viability assay, IC50 = 0.84958 μM.	SANGER
ML-2	Growth Inhibition Assay	Inhibition of human ML-2 cell growth in a cell viability assay, IC50 = 0.85575 μM.	SANGER
CAL-62	Growth Inhibition Assay	Inhibition of human CAL-62 cell growth in a cell viability assay, IC50 = 0.88152 μM.	SANGER
HL-60	Growth Inhibition Assay	Inhibition of human HL-60 cell growth in a cell viability assay, IC50 = 0.88362 μM.	SANGER
KY821	Growth Inhibition Assay	Inhibition of human KY821 cell growth in a cell viability assay, IC50 = 0.88812 μM.	SANGER
ES7	Growth Inhibition Assay	Inhibition of human ES7 cell growth in a cell viability assay, IC50 = 0.91607 μM.	SANGER
MV-4-11	Growth Inhibition Assay	Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50 = 0.97897 μM.	SANGER
Daoy	Growth Inhibition Assay	Inhibition of human Daoy cell growth in a cell viability assay, IC50 = 0.98767 μM.	SANGER
EoL-1-cell	Growth Inhibition Assay	Inhibition of human EoL-1-cell cell growth in a cell viability assay, IC50 = 1.01878 μM.	SANGER
TGW	Growth Inhibition Assay	Inhibition of human TGW cell growth in a cell viability assay, IC50 = 1.05124 μM.	SANGER
LAMA-84	Growth Inhibition Assay	Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50 = 1.12794 μM.	SANGER
KOSC-2	Growth Inhibition Assay	Inhibition of human KOSC-2 cell growth in a cell viability assay, IC50 = 1.13385 μM.	SANGER
A549	Growth Inhibition Assay	Inhibition of human A549 cell growth in a cell viability assay, IC50 = 1.30955 μM.	SANGER
CTB-1	Growth Inhibition Assay	Inhibition of human CTB-1 cell growth in a cell viability assay, IC50 = 1.44679 μM.	SANGER
NCI-H292	Growth Inhibition Assay	Inhibition of human NCI-H292 cell growth in a cell viability assay, IC50 = 1.46069 μM.	SANGER
LoVo	Growth Inhibition Assay	Inhibition of human LoVo cell growth in a cell viability assay, IC50 = 1.46755 μM.	SANGER
BFTC-905	Growth Inhibition Assay	Inhibition of human BFTC-905 cell growth in a cell viability assay, IC50 = 1.56332 μM.	SANGER
BE-13	Growth Inhibition Assay	Inhibition of human BE-13 cell growth in a cell viability assay, IC50 = 1.58709 μM.	SANGER
KE-37	Growth Inhibition Assay	Inhibition of human KE-37 cell growth in a cell viability assay, IC50 = 1.59478 μM.	SANGER
HN	Growth Inhibition Assay	Inhibition of human HN cell growth in a cell viability assay, IC50 = 1.61368 μM.	SANGER
A3-KAW	Growth Inhibition Assay	Inhibition of human A3-KAW cell growth in a cell viability assay, IC50 = 1.62834 μM.	SANGER
NEC8	Growth Inhibition Assay	Inhibition of human NEC8 cell growth in a cell viability assay, IC50 = 1.70115 μM.	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay	Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay, IC50 = 1.70444 μM.	SANGER
NB10	Growth Inhibition Assay	Inhibition of human NB10 cell growth in a cell viability assay, IC50 = 1.7763 μM.	SANGER
NBsusSR	Growth Inhibition Assay	Inhibition of human NBsusSR cell growth in a cell viability assay, IC50 = 1.82961 μM.	SANGER
ES4	Growth Inhibition Assay	Inhibition of human ES4 cell growth in a cell viability assay, IC50 = 1.85143 μM.	SANGER
ES8	Growth Inhibition Assay	Inhibition of human ES8 cell growth in a cell viability assay, IC50 = 1.87724 μM.	SANGER
CHL-1	Growth Inhibition Assay	Inhibition of human CHL-1 cell growth in a cell viability assay, IC50 = 1.95792 μM.	SANGER
NCI-H2029	Growth Inhibition Assay	Inhibition of human NCI-H2029 cell growth in a cell viability assay, IC50 = 1.97241 μM.	SANGER
YKG-1	Growth Inhibition Assay	Inhibition of human YKG-1 cell growth in a cell viability assay, IC50 = 1.98432 μM.	SANGER
BV-173	Growth Inhibition Assay	Inhibition of human BV-173 cell growth in a cell viability assay, IC50 = 1.98666 μM.	SANGER
697	Growth Inhibition Assay	Inhibition of human 697 cell growth in a cell viability assay, IC50 = 2.02228 μM.	SANGER
SK-NEP-1	Growth Inhibition Assay	Inhibition of human SK-NEP-1 cell growth in a cell viability assay, IC50 = 2.044 μM.	SANGER
LOXIMVI	Growth Inhibition Assay	Inhibition of human LOXIMVI cell growth in a cell viability assay, IC50 = 2.04434 μM.	SANGER
QIMR-WIL	Growth Inhibition Assay	Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50 = 2.07849 μM.	SANGER
DU-145	Growth Inhibition Assay	Inhibition of human DU-145 cell growth in a cell viability assay, IC50 = 2.11056 μM.	SANGER
NB14	Growth Inhibition Assay	Inhibition of human NB14 cell growth in a cell viability assay, IC50 = 2.11321 μM.	SANGER
G-361	Growth Inhibition Assay	Inhibition of human G-361 cell growth in a cell viability assay, IC50 = 2.1221 μM.	SANGER
BPH-1	Growth Inhibition Assay	Inhibition of human BPH-1 cell growth in a cell viability assay, IC50 = 2.12957 μM.	SANGER
KYSE-150	Growth Inhibition Assay	Inhibition of human KYSE-150 cell growth in a cell viability assay, IC50 = 2.15234 μM.	SANGER
HMV-II	Growth Inhibition Assay	Inhibition of human HMV-II cell growth in a cell viability assay, IC50 = 2.16633 μM.	SANGER
TE-9	Growth Inhibition Assay	Inhibition of human TE-9 cell growth in a cell viability assay, IC50 = 2.17376 μM.	SANGER
8-MG-BA	Growth Inhibition Assay	Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50 = 2.23461 μM.	SANGER
ES5	Growth Inhibition Assay	Inhibition of human ES5 cell growth in a cell viability assay, IC50 = 2.23633 μM.	SANGER
D-283MED	Growth Inhibition Assay	Inhibition of human D-283MED cell growth in a cell viability assay, IC50 = 2.23695 μM.	SANGER
SK-N-AS	Growth Inhibition Assay	Inhibition of human SK-N-AS cell growth in a cell viability assay, IC50 = 2.29059 μM.	SANGER
SW1710	Growth Inhibition Assay	Inhibition of human SW1710 cell growth in a cell viability assay, IC50 = 2.30661 μM.	SANGER
GCT	Growth Inhibition Assay	Inhibition of human GCT cell growth in a cell viability assay, IC50 = 2.31358 μM.	SANGER
AGS	Growth Inhibition Assay	Inhibition of human AGS cell growth in a cell viability assay, IC50 = 2.34404 μM.	SANGER
HuO9	Growth Inhibition Assay	Inhibition of human HuO9 cell growth in a cell viability assay, IC50 = 2.36824 μM.	SANGER
MN-60	Growth Inhibition Assay	Inhibition of human MN-60 cell growth in a cell viability assay, IC50 = 2.44883 μM.	SANGER
NB6	Growth Inhibition Assay	Inhibition of human NB6 cell growth in a cell viability assay, IC50 = 2.45779 μM.	SANGER
NCI-H1395	Growth Inhibition Assay	Inhibition of human NCI-H1395 cell growth in a cell viability assay, IC50 = 2.47121 μM.	SANGER
H4	Growth Inhibition Assay	Inhibition of human H4 cell growth in a cell viability assay, IC50 = 2.48393 μM.	SANGER
HT-3	Growth Inhibition Assay	Inhibition of human HT-3 cell growth in a cell viability assay, IC50 = 2.51024 μM.	SANGER
P12-ICHIKAWA	Growth Inhibition Assay	Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay, IC50 = 2.52559 μM.	SANGER
COLO-800	Growth Inhibition Assay	Inhibition of human COLO-800 cell growth in a cell viability assay, IC50 = 2.54166 μM.	SANGER
DB	Growth Inhibition Assay	Inhibition of human DB cell growth in a cell viability assay, IC50 = 2.55013 μM.	SANGER
LCLC-97TM1	Growth Inhibition Assay	Inhibition of human LCLC-97TM1 cell growth in a cell viability assay, IC50 = 2.60028 μM.	SANGER
Ca9-22	Growth Inhibition Assay	Inhibition of human Ca9-22 cell growth in a cell viability assay, IC50 = 2.65933 μM.	SANGER
Becker	Growth Inhibition Assay	Inhibition of human Becker cell growth in a cell viability assay, IC50 = 2.66078 μM.	SANGER
ACN	Growth Inhibition Assay	Inhibition of human ACN cell growth in a cell viability assay, IC50 = 2.6679 μM.	SANGER
SJSA-1	Growth Inhibition Assay	Inhibition of human SJSA-1 cell growth in a cell viability assay, IC50 = 2.6687 μM.	SANGER
NCI-H1048	Growth Inhibition Assay	Inhibition of human NCI-H1048 cell growth in a cell viability assay, IC50 = 2.68321 μM.	SANGER
HEL	Growth Inhibition Assay	Inhibition of human HEL cell growth in a cell viability assay, IC50 = 2.70254 μM.	SANGER
NCI-H69	Growth Inhibition Assay	Inhibition of human NCI-H69 cell growth in a cell viability assay, IC50 = 2.71601 μM.	SANGER
639-V	Growth Inhibition Assay	Inhibition of human 639-V cell growth in a cell viability assay, IC50 = 2.71703 μM.	SANGER
U251	Growth Inhibition Assay	Inhibition of human U251 cell growth in a cell viability assay, IC50 = 2.73032 μM.	SANGER
NCI-H1792	Growth Inhibition Assay	Inhibition of human NCI-H1792 cell growth in a cell viability assay, IC50 = 2.73738 μM.	SANGER
EW-1	Growth Inhibition Assay	Inhibition of human EW-1 cell growth in a cell viability assay, IC50 = 2.75328 μM.	SANGER
ME-180	Growth Inhibition Assay	Inhibition of human ME-180 cell growth in a cell viability assay, IC50 = 2.77736 μM.	SANGER
HH	Growth Inhibition Assay	Inhibition of human HH cell growth in a cell viability assay, IC50 = 2.80001 μM.	SANGER
SW954	Growth Inhibition Assay	Inhibition of human SW954 cell growth in a cell viability assay, IC50 = 2.8583 μM.	SANGER
SF268	Growth Inhibition Assay	Inhibition of human SF268 cell growth in a cell viability assay, IC50 = 2.87225 μM.	SANGER
D-566MG	Growth Inhibition Assay	Inhibition of human D-566MG cell growth in a cell viability assay, IC50 = 2.91295 μM.	SANGER
EM-2	Growth Inhibition Assay	Inhibition of human EM-2 cell growth in a cell viability assay, IC50 = 2.92193 μM.	SANGER
NCI-H1299	Growth Inhibition Assay	Inhibition of human NCI-H1299 cell growth in a cell viability assay, IC50 = 2.93736 μM.	SANGER
PSN1	Growth Inhibition Assay	Inhibition of human PSN1 cell growth in a cell viability assay, IC50 = 3.05786 μM.	SANGER
JVM-3	Growth Inhibition Assay	Inhibition of human JVM-3 cell growth in a cell viability assay, IC50 = 3.06756 μM.	SANGER
D-502MG	Growth Inhibition Assay	Inhibition of human D-502MG cell growth in a cell viability assay, IC50 = 3.07019 μM.	SANGER
SCC-4	Growth Inhibition Assay	Inhibition of human SCC-4 cell growth in a cell viability assay, IC50 = 3.09276 μM.	SANGER
GMS-10	Growth Inhibition Assay	Inhibition of human GMS-10 cell growth in a cell viability assay, IC50 = 3.09388 μM.	SANGER
A427	Growth Inhibition Assay	Inhibition of human A427 cell growth in a cell viability assay, IC50 = 3.10873 μM.	SANGER
NH-12	Growth Inhibition Assay	Inhibition of human NH-12 cell growth in a cell viability assay, IC50 = 3.11456 μM.	SANGER
KM12	Growth Inhibition Assay	Inhibition of human KM12 cell growth in a cell viability assay, IC50 = 3.12273 μM.	SANGER
GI-1	Growth Inhibition Assay	Inhibition of human GI-1 cell growth in a cell viability assay, IC50 = 3.15255 μM.	SANGER
TE-8	Growth Inhibition Assay	Inhibition of human TE-8 cell growth in a cell viability assay, IC50 = 3.19231 μM.	SANGER
MKN1	Growth Inhibition Assay	Inhibition of human MKN1 cell growth in a cell viability assay, IC50 = 3.20875 μM.	SANGER
NCI-H810	Growth Inhibition Assay	Inhibition of human NCI-H810 cell growth in a cell viability assay, IC50 = 3.22155 μM.	SANGER
GOTO	Growth Inhibition Assay	Inhibition of human GOTO cell growth in a cell viability assay, IC50 = 3.28004 μM.	SANGER
T98G	Growth Inhibition Assay	Inhibition of human T98G cell growth in a cell viability assay, IC50 = 3.28216 μM.	SANGER
HD-MY-Z	Growth Inhibition Assay	Inhibition of human HD-MY-Z cell growth in a cell viability assay, IC50 = 3.36542 μM.	SANGER
SNU-C2B	Growth Inhibition Assay	Inhibition of human SNU-C2B cell growth in a cell viability assay, IC50 = 3.39097 μM.	SANGER
MOLT-4	Growth Inhibition Assay	Inhibition of human MOLT-4 cell growth in a cell viability assay, IC50 = 3.39098 μM.	SANGER
RPMI-7951	Growth Inhibition Assay	Inhibition of human RPMI-7951 cell growth in a cell viability assay, IC50 = 3.3973 μM.	SANGER
EW-11	Growth Inhibition Assay	Inhibition of human EW-11 cell growth in a cell viability assay, IC50 = 3.41224 μM.	SANGER
RD	Growth Inhibition Assay	Inhibition of human RD cell growth in a cell viability assay, IC50 = 3.43132 μM.	SANGER
SW48	Growth Inhibition Assay	Inhibition of human SW48 cell growth in a cell viability assay, IC50 = 3.43358 μM.	SANGER
BB65-RCC	Growth Inhibition Assay	Inhibition of human BB65-RCC cell growth in a cell viability assay, IC50 = 3.45396 μM.	SANGER
Ca-Ski	Growth Inhibition Assay	Inhibition of human Ca-Ski cell growth in a cell viability assay, IC50 = 3.47514 μM.	SANGER
CHP-134	Growth Inhibition Assay	Inhibition of human CHP-134 cell growth in a cell viability assay, IC50 = 3.48758 μM.	SANGER
CAL-33	Growth Inhibition Assay	Inhibition of human CAL-33 cell growth in a cell viability assay, IC50 = 3.53362 μM.	SANGER
TYK-nu	Growth Inhibition Assay	Inhibition of human TYK-nu cell growth in a cell viability assay, IC50 = 3.53676 μM.	SANGER
LB831-BLC	Growth Inhibition Assay	Inhibition of human LB831-BLC cell growth in a cell viability assay, IC50 = 3.54016 μM.	SANGER
KU-19-19	Growth Inhibition Assay	Inhibition of human KU-19-19 cell growth in a cell viability assay, IC50 = 3.60304 μM.	SANGER
KG-1	Growth Inhibition Assay	Inhibition of human KG-1 cell growth in a cell viability assay, IC50 = 3.61106 μM.	SANGER
COLO-829	Growth Inhibition Assay	Inhibition of human COLO-829 cell growth in a cell viability assay, IC50 = 3.66618 μM.	SANGER
HUTU-80	Growth Inhibition Assay	Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50 = 3.66621 μM.	SANGER
NCI-H446	Growth Inhibition Assay	Inhibition of human NCI-H446 cell growth in a cell viability assay, IC50 = 3.6834 μM.	SANGER
LB2241-RCC	Growth Inhibition Assay	Inhibition of human LB2241-RCC cell growth in a cell viability assay, IC50 = 3.68625 μM.	SANGER
JEG-3	Growth Inhibition Assay	Inhibition of human JEG-3 cell growth in a cell viability assay, IC50 = 3.6919 μM.	SANGER
LNCaP-Clone-FGC	Growth Inhibition Assay	Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay, IC50 = 3.70041 μM.	SANGER
M059J	Growth Inhibition Assay	Inhibition of human M059J cell growth in a cell viability assay, IC50 = 3.71468 μM.	SANGER
SK-MES-1	Growth Inhibition Assay	Inhibition of human SK-MES-1 cell growth in a cell viability assay, IC50 = 3.7303 μM.	SANGER
GT3TKB	Growth Inhibition Assay	Inhibition of human GT3TKB cell growth in a cell viability assay, IC50 = 3.75604 μM.	SANGER
DOK	Growth Inhibition Assay	Inhibition of human DOK cell growth in a cell viability assay, IC50 = 3.76526 μM.	SANGER
HO-1-N-1	Growth Inhibition Assay	Inhibition of human HO-1-N-1 cell growth in a cell viability assay, IC50 = 3.79801 μM.	SANGER
MZ1-PC	Growth Inhibition Assay	Inhibition of human MZ1-PC cell growth in a cell viability assay, IC50 = 3.82883 μM.	SANGER
8305C	Growth Inhibition Assay	Inhibition of human 8305C cell growth in a cell viability assay, IC50 = 3.88943 μM.	SANGER
CGTH-W-1	Growth Inhibition Assay	Inhibition of human CGTH-W-1 cell growth in a cell viability assay, IC50 = 3.93504 μM.	SANGER
LU-134-A	Growth Inhibition Assay	Inhibition of human LU-134-A cell growth in a cell viability assay, IC50 = 3.95422 μM.	SANGER
C32	Growth Inhibition Assay	Inhibition of human C32 cell growth in a cell viability assay, IC50 = 3.96581 μM.	SANGER
MOLT-13	Growth Inhibition Assay	Inhibition of human MOLT-13 cell growth in a cell viability assay, IC50 = 3.96856 μM.	SANGER
A375	Growth Inhibition Assay	Inhibition of human A375 cell growth in a cell viability assay, IC50 = 4.05162 μM.	SANGER
CAL-12T	Growth Inhibition Assay	Inhibition of human CAL-12T cell growth in a cell viability assay, IC50 = 4.05795 μM.	SANGER
IGR-1	Growth Inhibition Assay	Inhibition of human IGR-1 cell growth in a cell viability assay, IC50 = 4.10274 μM.	SANGER
LB1047-RCC	Growth Inhibition Assay	Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50 = 4.10441 μM.	SANGER
BHT-101	Growth Inhibition Assay	Inhibition of human BHT-101 cell growth in a cell viability assay, IC50 = 4.10683 μM.	SANGER
A431	Growth Inhibition Assay	Inhibition of human A431 cell growth in a cell viability assay, IC50 = 4.14081 μM.	SANGER
EPLC-272H	Growth Inhibition Assay	Inhibition of human EPLC-272H cell growth in a cell viability assay, IC50 = 4.17596 μM.	SANGER
HT-1376	Growth Inhibition Assay	Inhibition of human HT-1376 cell growth in a cell viability assay, IC50 = 4.23059 μM.	SANGER
HCC1954	Growth Inhibition Assay	Inhibition of human HCC1954 cell growth in a cell viability assay, IC50 = 4.25746 μM.	SANGER
KYSE-510	Growth Inhibition Assay	Inhibition of human KYSE-510 cell growth in a cell viability assay, IC50 = 4.2609 μM.	SANGER
PANC-03-27	Growth Inhibition Assay	Inhibition of human PANC-03-27 cell growth in a cell viability assay, IC50 = 4.30083 μM.	SANGER
MDA-MB-157	Growth Inhibition Assay	Inhibition of human MDA-MB-157 cell growth in a cell viability assay, IC50 = 4.30656 μM.	SANGER
HOP-62	Growth Inhibition Assay	Inhibition of human HOP-62 cell growth in a cell viability assay, IC50 = 4.30856 μM.	SANGER
ETK-1	Growth Inhibition Assay	Inhibition of human ETK-1 cell growth in a cell viability assay, IC50 = 4.36203 μM.	SANGER
MIA-PaCa-2	Growth Inhibition Assay	Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay, IC50 = 4.36227 μM.	SANGER
MHH-PREB-1	Growth Inhibition Assay	Inhibition of human MHH-PREB-1 cell growth in a cell viability assay, IC50 = 4.39773 μM.	SANGER
LXF-289	Growth Inhibition Assay	Inhibition of human LXF-289 cell growth in a cell viability assay, IC50 = 4.40202 μM.	SANGER
ATN-1	Growth Inhibition Assay	Inhibition of human ATN-1 cell growth in a cell viability assay, IC50 = 4.42341 μM.	SANGER
8505C	Growth Inhibition Assay	Inhibition of human 8505C cell growth in a cell viability assay, IC50 = 4.45825 μM.	SANGER
HOS	Growth Inhibition Assay	Inhibition of human HOS cell growth in a cell viability assay, IC50 = 4.46453 μM.	SANGER
U-266	Growth Inhibition Assay	Inhibition of human U-266 cell growth in a cell viability assay, IC50 = 4.61032 μM.	SANGER
5637	Growth Inhibition Assay	Inhibition of human 5637 cell growth in a cell viability assay, IC50 = 4.61444 μM.	SANGER
GCIY	Growth Inhibition Assay	Inhibition of human GCIY cell growth in a cell viability assay, IC50 = 4.71015 μM.	SANGER
MDA-MB-231	Growth Inhibition Assay	Inhibition of human MDA-MB-231 cell growth in a cell viability assay, IC50 = 4.72115 μM.	SANGER
RKO	Growth Inhibition Assay	Inhibition of human RKO cell growth in a cell viability assay, IC50 = 4.72817 μM.	SANGER
COR-L23	Growth Inhibition Assay	Inhibition of human COR-L23 cell growth in a cell viability assay, IC50 = 4.74256 μM.	SANGER
DJM-1	Growth Inhibition Assay	Inhibition of human DJM-1 cell growth in a cell viability assay, IC50 = 4.79729 μM.	SANGER
D-423MG	Growth Inhibition Assay	Inhibition of human D-423MG cell growth in a cell viability assay, IC50 = 4.80803 μM.	SANGER
DMS-114	Growth Inhibition Assay	Inhibition of human DMS-114 cell growth in a cell viability assay, IC50 = 4.81386 μM.	SANGER
MHH-ES-1	Growth Inhibition Assay	Inhibition of human MHH-ES-1 cell growth in a cell viability assay, IC50 = 4.82504 μM.	SANGER
CAL-51	Growth Inhibition Assay	Inhibition of human CAL-51 cell growth in a cell viability assay, IC50 = 4.86843 μM.	SANGER
SW626	Growth Inhibition Assay	Inhibition of human SW626 cell growth in a cell viability assay, IC50 = 4.89697 μM.	SANGER
COLO-824	Growth Inhibition Assay	Inhibition of human COLO-824 cell growth in a cell viability assay, IC50 = 4.90408 μM.	SANGER
NCI-H1437	Growth Inhibition Assay	Inhibition of human NCI-H1437 cell growth in a cell viability assay, IC50 = 4.9293 μM.	SANGER
CAL-39	Growth Inhibition Assay	Inhibition of human CAL-39 cell growth in a cell viability assay, IC50 = 4.93988 μM.	SANGER
PC-3	Growth Inhibition Assay	Inhibition of human PC-3 cell growth in a cell viability assay, IC50 = 4.94648 μM.	SANGER
A101D	Growth Inhibition Assay	Inhibition of human A101D cell growth in a cell viability assay, IC50 = 4.96865 μM.	SANGER
ES1	Growth Inhibition Assay	Inhibition of human ES1 cell growth in a cell viability assay, IC50 = 5.0013 μM.	SANGER
TE-1	Growth Inhibition Assay	Inhibition of human TE-1 cell growth in a cell viability assay, IC50 = 5.03666 μM.	SANGER
KP-N-YN	Growth Inhibition Assay	Inhibition of human KP-N-YN cell growth in a cell viability assay, IC50 = 5.0567 μM.	SANGER
EFO-27	Growth Inhibition Assay	Inhibition of human EFO-27 cell growth in a cell viability assay, IC50 = 5.06329 μM.	SANGER
BT-549	Growth Inhibition Assay	Inhibition of human BT-549 cell growth in a cell viability assay, IC50 = 5.07736 μM.	SANGER
HLE	Growth Inhibition Assay	Inhibition of human HLE cell growth in a cell viability assay, IC50 = 5.11734 μM.	SANGER
SW982	Growth Inhibition Assay	Inhibition of human SW982 cell growth in a cell viability assay, IC50 = 5.13374 μM.	SANGER
SCC-25	Growth Inhibition Assay	Inhibition of human SCC-25 cell growth in a cell viability assay, IC50 = 5.19046 μM.	SANGER
SK-MEL-28	Growth Inhibition Assay	Inhibition of human SK-MEL-28 cell growth in a cell viability assay, IC50 = 5.20313 μM.	SANGER
CaR-1	Growth Inhibition Assay	Inhibition of human CaR-1 cell growth in a cell viability assay, IC50 = 5.20726 μM.	SANGER
MLMA	Growth Inhibition Assay	Inhibition of human MLMA cell growth in a cell viability assay, IC50 = 5.23436 μM.	SANGER
VM-CUB-1	Growth Inhibition Assay	Inhibition of human VM-CUB-1 cell growth in a cell viability assay, IC50 = 5.23439 μM.	SANGER
KNS-42	Growth Inhibition Assay	Inhibition of human KNS-42 cell growth in a cell viability assay, IC50 = 5.2616 μM.	SANGER
TK10	Growth Inhibition Assay	Inhibition of human TK10 cell growth in a cell viability assay, IC50 = 5.36086 μM.	SANGER
MEG-01	Growth Inhibition Assay	Inhibition of human MEG-01 cell growth in a cell viability assay, IC50 = 5.36274 μM.	SANGER
DEL	Growth Inhibition Assay	Inhibition of human DEL cell growth in a cell viability assay, IC50 = 5.39023 μM.	SANGER
SJRH30	Growth Inhibition Assay	Inhibition of human SJRH30 cell growth in a cell viability assay, IC50 = 5.39213 μM.	SANGER
SK-PN-DW	Growth Inhibition Assay	Inhibition of human SK-PN-DW cell growth in a cell viability assay, IC50 = 5.43589 μM.	SANGER
TE-10	Growth Inhibition Assay	Inhibition of human TE-10 cell growth in a cell viability assay, IC50 = 5.44893 μM.	SANGER
KNS-81-FD	Growth Inhibition Assay	Inhibition of human KNS-81-FD cell growth in a cell viability assay, IC50 = 5.50092 μM.	SANGER
BHY	Growth Inhibition Assay	Inhibition of human BHY cell growth in a cell viability assay, IC50 = 5.5107 μM.	SANGER
KYSE-270	Growth Inhibition Assay	Inhibition of human KYSE-270 cell growth in a cell viability assay, IC50 = 5.53536 μM.	SANGER
NCI-H650	Growth Inhibition Assay	Inhibition of human NCI-H650 cell growth in a cell viability assay, IC50 = 5.57114 μM.	SANGER
L-363	Growth Inhibition Assay	Inhibition of human L-363 cell growth in a cell viability assay, IC50 = 5.69476 μM.	SANGER
TCCSUP	Growth Inhibition Assay	Inhibition of human TCCSUP cell growth in a cell viability assay, IC50 = 5.71778 μM.	SANGER
SCH	Growth Inhibition Assay	Inhibition of human SCH cell growth in a cell viability assay, IC50 = 5.74767 μM.	SANGER
HTC-C3	Growth Inhibition Assay	Inhibition of human HTC-C3 cell growth in a cell viability assay, IC50 = 5.77644 μM.	SANGER
J-RT3-T3-5	Growth Inhibition Assay	Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay, IC50 = 5.80794 μM.	SANGER
Hs-578-T	Growth Inhibition Assay	Inhibition of human Hs-578-T cell growth in a cell viability assay, IC50 = 5.83607 μM.	SANGER
M14	Growth Inhibition Assay	Inhibition of human M14 cell growth in a cell viability assay, IC50 = 5.86726 μM.	SANGER
HT-144	Growth Inhibition Assay	Inhibition of human HT-144 cell growth in a cell viability assay, IC50 = 5.86832 μM.	SANGER
CAL-54	Growth Inhibition Assay	Inhibition of human CAL-54 cell growth in a cell viability assay, IC50 = 5.93314 μM.	SANGER
T47D	Growth Inhibition Assay	Inhibition of human T47D cell growth in a cell viability assay, IC50 = 5.9612 μM.	SANGER
GB-1	Growth Inhibition Assay	Inhibition of human GB-1 cell growth in a cell viability assay, IC50 = 6.02068 μM.	SANGER
HSC-2	Growth Inhibition Assay	Inhibition of human HSC-2 cell growth in a cell viability assay, IC50 = 6.12353 μM.	SANGER
SiHa	Growth Inhibition Assay	Inhibition of human SiHa cell growth in a cell viability assay, IC50 = 6.14097 μM.	SANGER
OMC-1	Growth Inhibition Assay	Inhibition of human OMC-1 cell growth in a cell viability assay, IC50 = 6.35441 μM.	SANGER
HGC-27	Growth Inhibition Assay	Inhibition of human HGC-27 cell growth in a cell viability assay, IC50 = 6.35786 μM.	SANGER
FTC-133	Growth Inhibition Assay	Inhibition of human FTC-133 cell growth in a cell viability assay, IC50 = 6.46551 μM.	SANGER
KS-1	Growth Inhibition Assay	Inhibition of human KS-1 cell growth in a cell viability assay, IC50 = 6.52147 μM.	SANGER
HT-1080	Growth Inhibition Assay	Inhibition of human HT-1080 cell growth in a cell viability assay, IC50 = 6.54042 μM.	SANGER
SKG-IIIa	Growth Inhibition Assay	Inhibition of human SKG-IIIa cell growth in a cell viability assay, IC50 = 6.56263 μM.	SANGER
OCUB-M	Growth Inhibition Assay	Inhibition of human OCUB-M cell growth in a cell viability assay, IC50 = 6.6077 μM.	SANGER
MDA-MB-175-VII	Growth Inhibition Assay	Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay, IC50 = 6.6209 μM.	SANGER
BB30-HNC	Growth Inhibition Assay	Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50 = 6.67444 μM.	SANGER
D-542MG	Growth Inhibition Assay	Inhibition of human D-542MG cell growth in a cell viability assay, IC50 = 6.7309 μM.	SANGER
NCI-H2405	Growth Inhibition Assay	Inhibition of human NCI-H2405 cell growth in a cell viability assay, IC50 = 6.74855 μM.	SANGER
SW1573	Growth Inhibition Assay	Inhibition of human SW1573 cell growth in a cell viability assay, IC50 = 6.78319 μM.	SANGER
NCI-SNU-1	Growth Inhibition Assay	Inhibition of human NCI-SNU-1 cell growth in a cell viability assay, IC50 = 6.79022 μM.	SANGER
RT-112	Growth Inhibition Assay	Inhibition of human RT-112 cell growth in a cell viability assay, IC50 = 6.79463 μM.	SANGER
COR-L88	Growth Inhibition Assay	Inhibition of human COR-L88 cell growth in a cell viability assay, IC50 = 6.79791 μM.	SANGER
SCC-9	Growth Inhibition Assay	Inhibition of human SCC-9 cell growth in a cell viability assay, IC50 = 6.8255 μM.	SANGER
U-87-MG	Growth Inhibition Assay	Inhibition of human U-87-MG cell growth in a cell viability assay, IC50 = 6.83826 μM.	SANGER
Detroit562	Growth Inhibition Assay	Inhibition of human Detroit562 cell growth in a cell viability assay, IC50 = 6.85991 μM.	SANGER
LC-2-ad	Growth Inhibition Assay	Inhibition of human LC-2-ad cell growth in a cell viability assay, IC50 = 6.86292 μM.	SANGER
IGROV-1	Growth Inhibition Assay	Inhibition of human IGROV-1 cell growth in a cell viability assay, IC50 = 6.92583 μM.	SANGER
OVCAR-8	Growth Inhibition Assay	Inhibition of human OVCAR-8 cell growth in a cell viability assay, IC50 = 6.94229 μM.	SANGER
SNU-387	Growth Inhibition Assay	Inhibition of human SNU-387 cell growth in a cell viability assay, IC50 = 6.99516 μM.	SANGER
TGBC1TKB	Growth Inhibition Assay	Inhibition of human TGBC1TKB cell growth in a cell viability assay, IC50 = 7.15277 μM.	SANGER
NOS-1	Growth Inhibition Assay	Inhibition of human NOS-1 cell growth in a cell viability assay, IC50 = 7.20415 μM.	SANGER
HEC-1	Growth Inhibition Assay	Inhibition of human HEC-1 cell growth in a cell viability assay, IC50 = 7.25387 μM.	SANGER
GI-ME-N	Growth Inhibition Assay	Inhibition of human GI-ME-N cell growth in a cell viability assay, IC50 = 7.29158 μM.	SANGER
KYSE-520	Growth Inhibition Assay	Inhibition of human KYSE-520 cell growth in a cell viability assay, IC50 = 7.2929 μM.	SANGER
SNU-423	Growth Inhibition Assay	Inhibition of human SNU-423 cell growth in a cell viability assay, IC50 = 7.29452 μM.	SANGER
C-33-A	Growth Inhibition Assay	Inhibition of human C-33-A cell growth in a cell viability assay, IC50 = 7.4782 μM.	SANGER
SK-UT-1	Growth Inhibition Assay	Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50 = 7.54829 μM.	SANGER
OVCAR-4	Growth Inhibition Assay	Inhibition of human OVCAR-4 cell growth in a cell viability assay, IC50 = 7.5526 μM.	SANGER
KYSE-450	Growth Inhibition Assay	Inhibition of human KYSE-450 cell growth in a cell viability assay, IC50 = 7.63791 μM.	SANGER
RS4-11	Growth Inhibition Assay	Inhibition of human RS4-11 cell growth in a cell viability assay, IC50 = 7.70196 μM.	SANGER
OVCAR-5	Growth Inhibition Assay	Inhibition of human OVCAR-5 cell growth in a cell viability assay, IC50 = 7.82329 μM.	SANGER
K5	Growth Inhibition Assay	Inhibition of human K5 cell growth in a cell viability assay, IC50 = 7.8742 μM.	SANGER
786-0	Growth Inhibition Assay	Inhibition of human 786-0 cell growth in a cell viability assay, IC50 = 8.03095 μM.	SANGER
NCI-H747	Growth Inhibition Assay	Inhibition of human NCI-H747 cell growth in a cell viability assay, IC50 = 8.04457 μM.	SANGER
CAL-27	Growth Inhibition Assay	Inhibition of human CAL-27 cell growth in a cell viability assay, IC50 = 8.1272 μM.	SANGER
FADU	Growth Inhibition Assay	Inhibition of human FADU cell growth in a cell viability assay, IC50 = 8.17543 μM.	SANGER
SW780	Growth Inhibition Assay	Inhibition of human SW780 cell growth in a cell viability assay, IC50 = 8.18821 μM.	SANGER
ACHN	Growth Inhibition Assay	Inhibition of human ACHN cell growth in a cell viability assay, IC50 = 8.22529 μM.	SANGER
TE-6	Growth Inhibition Assay	Inhibition of human TE-6 cell growth in a cell viability assay, IC50 = 8.23788 μM.	SANGER
NCI-H2087	Growth Inhibition Assay	Inhibition of human NCI-H2087 cell growth in a cell viability assay, IC50 = 8.36158 μM.	SANGER
NCI-H2122	Growth Inhibition Assay	Inhibition of human NCI-H2122 cell growth in a cell viability assay, IC50 = 8.40479 μM.	SANGER
SK-LU-1	Growth Inhibition Assay	Inhibition of human SK-LU-1 cell growth in a cell viability assay, IC50 = 8.43997 μM.	SANGER
22RV1	Growth Inhibition Assay	Inhibition of human 22RV1 cell growth in a cell viability assay, IC50 = 8.61786 μM.	SANGER
MEL-JUSO	Growth Inhibition Assay	Inhibition of human MEL-JUSO cell growth in a cell viability assay, IC50 = 8.68675 μM.	SANGER
UM-UC-3	Growth Inhibition Assay	Inhibition of human UM-UC-3 cell growth in a cell viability assay, IC50 = 8.7139 μM.	SANGER
HuH-7	Growth Inhibition Assay	Inhibition of human HuH-7 cell growth in a cell viability assay, IC50 = 8.73012 μM.	SANGER
SNU-449	Growth Inhibition Assay	Inhibition of human SNU-449 cell growth in a cell viability assay, IC50 = 8.75265 μM.	SANGER
RVH-421	Growth Inhibition Assay	Inhibition of human RVH-421 cell growth in a cell viability assay, IC50 = 8.75398 μM.	SANGER
MFM-223	Growth Inhibition Assay	Inhibition of human MFM-223 cell growth in a cell viability assay, IC50 = 8.80735 μM.	SANGER
CHP-212	Growth Inhibition Assay	Inhibition of human CHP-212 cell growth in a cell viability assay, IC50 = 8.82267 μM.	SANGER
NCI-H28	Growth Inhibition Assay	Inhibition of human NCI-H28 cell growth in a cell viability assay, IC50 = 8.85185 μM.	SANGER
C8166	Growth Inhibition Assay	Inhibition of human C8166 cell growth in a cell viability assay, IC50 = 8.86772 μM.	SANGER
SCC-15	Growth Inhibition Assay	Inhibition of human SCC-15 cell growth in a cell viability assay, IC50 = 8.87196 μM.	SANGER
DMS-273	Growth Inhibition Assay	Inhibition of human DMS-273 cell growth in a cell viability assay, IC50 = 8.89623 μM.	SANGER
MPP-89	Growth Inhibition Assay	Inhibition of human MPP-89 cell growth in a cell viability assay, IC50 = 8.91341 μM.	SANGER
EW-22	Growth Inhibition Assay	Inhibition of human EW-22 cell growth in a cell viability assay, IC50 = 8.91382 μM.	SANGER
RCM-1	Growth Inhibition Assay	Inhibition of human RCM-1 cell growth in a cell viability assay, IC50 = 8.96486 μM.	SANGER
BT-474	Growth Inhibition Assay	Inhibition of human BT-474 cell growth in a cell viability assay, IC50 = 8.98872 μM.	SANGER
TI-73	Growth Inhibition Assay	Inhibition of human TI-73 cell growth in a cell viability assay, IC50 = 9.03496 μM.	SANGER
ES3	Growth Inhibition Assay	Inhibition of human ES3 cell growth in a cell viability assay, IC50 = 9.05156 μM.	SANGER
NB17	Growth Inhibition Assay	Inhibition of human NB17 cell growth in a cell viability assay, IC50 = 9.14535 μM.	SANGER
MOLT-16	Growth Inhibition Assay	Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50 = 9.16655 μM.	SANGER
TGBC11TKB	Growth Inhibition Assay	Inhibition of human TGBC11TKB cell growth in a cell viability assay, IC50 = 9.19205 μM.	SANGER
NB12	Growth Inhibition Assay	Inhibition of human NB12 cell growth in a cell viability assay, IC50 = 9.34081 μM.	SANGER
MEL-HO	Growth Inhibition Assay	Inhibition of human MEL-HO cell growth in a cell viability assay, IC50 = 9.402 μM.	SANGER
HuCCT1	Growth Inhibition Assay	Inhibition of human HuCCT1 cell growth in a cell viability assay, IC50 = 9.47406 μM.	SANGER
A704	Growth Inhibition Assay	Inhibition of human A704 cell growth in a cell viability assay, IC50 = 9.47745 μM.	SANGER
SW756	Growth Inhibition Assay	Inhibition of human SW756 cell growth in a cell viability assay, IC50 = 9.55361 μM.	SANGER
SAS	Growth Inhibition Assay	Inhibition of human SAS cell growth in a cell viability assay, IC50 = 9.58455 μM.	SANGER
KINGS-1	Growth Inhibition Assay	Inhibition of human KINGS-1 cell growth in a cell viability assay, IC50 = 9.6937 μM.	SANGER
NKM-1	Growth Inhibition Assay	Inhibition of human NKM-1 cell growth in a cell viability assay, IC50 = 9.83964 μM.	SANGER
C2BBe1	Growth Inhibition Assay	Inhibition of human C2BBe1 cell growth in a cell viability assay, IC50 = 9.86204 μM.	SANGER
A204	Growth Inhibition Assay	Inhibition of human A204 cell growth in a cell viability assay, IC50 = 9.89755 μM.	SANGER
G-401	Growth Inhibition Assay	Inhibition of human G-401 cell growth in a cell viability assay, IC50 = 9.90449 μM.	SANGER
PFSK-1	Growth Inhibition Assay	Inhibition of human PFSK-1 cell growth in a cell viability assay, IC50 = 9.95669 μM.	SANGER
KYSE-410	Growth Inhibition Assay	Inhibition of human KYSE-410 cell growth in a cell viability assay, IC50 = 10.0615 μM.	SANGER
SK-MEL-2	Growth Inhibition Assay	Inhibition of human SK-MEL-2 cell growth in a cell viability assay, IC50 = 10.1588 μM.	SANGER
NB5	Growth Inhibition Assay	Inhibition of human NB5 cell growth in a cell viability assay, IC50 = 10.5405 μM.	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay	Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50 = 10.5475 μM.	SANGER
MZ2-MEL	Growth Inhibition Assay	Inhibition of human MZ2-MEL cell growth in a cell viability assay, IC50 = 10.662 μM.	SANGER
SF539	Growth Inhibition Assay	Inhibition of human SF539 cell growth in a cell viability assay, IC50 = 10.7188 μM.	SANGER
CAL-120	Growth Inhibition Assay	Inhibition of human CAL-120 cell growth in a cell viability assay, IC50 = 10.7597 μM.	SANGER
GR-ST	Growth Inhibition Assay	Inhibition of human GR-ST cell growth in a cell viability assay, IC50 = 11.298 μM.	SANGER
IA-LM	Growth Inhibition Assay	Inhibition of human IA-LM cell growth in a cell viability assay, IC50 = 11.3486 μM.	SANGER
NCI-H2452	Growth Inhibition Assay	Inhibition of human NCI-H2452 cell growth in a cell viability assay, IC50 = 11.3927 μM.	SANGER
NCI-H1648	Growth Inhibition Assay	Inhibition of human NCI-H1648 cell growth in a cell viability assay, IC50 = 11.4629 μM.	SANGER
YH-13	Growth Inhibition Assay	Inhibition of human YH-13 cell growth in a cell viability assay, IC50 = 11.4742 μM.	SANGER
NCI-H2228	Growth Inhibition Assay	Inhibition of human NCI-H2228 cell growth in a cell viability assay, IC50 = 11.4928 μM.	SANGER
LN-405	Growth Inhibition Assay	Inhibition of human LN-405 cell growth in a cell viability assay, IC50 = 11.5927 μM.	SANGER
647-V	Growth Inhibition Assay	Inhibition of human 647-V cell growth in a cell viability assay, IC50 = 11.5974 μM.	SANGER
HCC1806	Growth Inhibition Assay	Inhibition of human HCC1806 cell growth in a cell viability assay, IC50 = 11.6134 μM.	SANGER
HPAF-II	Growth Inhibition Assay	Inhibition of human HPAF-II cell growth in a cell viability assay, IC50 = 11.8356 μM.	SANGER
BB49-HNC	Growth Inhibition Assay	Inhibition of human BB49-HNC cell growth in a cell viability assay, IC50 = 11.8375 μM.	SANGER
KGN	Growth Inhibition Assay	Inhibition of human KGN cell growth in a cell viability assay, IC50 = 11.859 μM.	SANGER
NOMO-1	Growth Inhibition Assay	Inhibition of human NOMO-1 cell growth in a cell viability assay, IC50 = 11.8597 μM.	SANGER
A388	Growth Inhibition Assay	Inhibition of human A388 cell growth in a cell viability assay, IC50 = 11.8808 μM.	SANGER
Saos-2	Growth Inhibition Assay	Inhibition of human Saos-2 cell growth in a cell viability assay, IC50 = 12.2004 μM.	SANGER
SK-HEP-1	Growth Inhibition Assay	Inhibition of human SK-HEP-1 cell growth in a cell viability assay, IC50 = 12.2613 μM.	SANGER
HCE-4	Growth Inhibition Assay	Inhibition of human HCE-4 cell growth in a cell viability assay, IC50 = 12.27 μM.	SANGER
NCI-H1581	Growth Inhibition Assay	Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50 = 12.2819 μM.	SANGER
NCI-H23	Growth Inhibition Assay	Inhibition of human NCI-H23 cell growth in a cell viability assay, IC50 = 12.3125 μM.	SANGER
NCI-H596	Growth Inhibition Assay	Inhibition of human NCI-H596 cell growth in a cell viability assay, IC50 = 12.4798 μM.	SANGER
NB69	Growth Inhibition Assay	Inhibition of human NB69 cell growth in a cell viability assay, IC50 = 12.7585 μM.	SANGER
ChaGo-K-1	Growth Inhibition Assay	Inhibition of human ChaGo-K-1 cell growth in a cell viability assay, IC50 = 12.7649 μM.	SANGER
EFM-19	Growth Inhibition Assay	Inhibition of human EFM-19 cell growth in a cell viability assay, IC50 = 12.7717 μM.	SANGER
SW962	Growth Inhibition Assay	Inhibition of human SW962 cell growth in a cell viability assay, IC50 = 12.8223 μM.	SANGER
KALS-1	Growth Inhibition Assay	Inhibition of human KALS-1 cell growth in a cell viability assay, IC50 = 13.095 μM.	SANGER
MDA-MB-415	Growth Inhibition Assay	Inhibition of human MDA-MB-415 cell growth in a cell viability assay, IC50 = 13.1609 μM.	SANGER
SW684	Growth Inhibition Assay	Inhibition of human SW684 cell growth in a cell viability assay, IC50 = 13.1861 μM.	SANGER
NCI-H2052	Growth Inhibition Assay	Inhibition of human NCI-H2052 cell growth in a cell viability assay, IC50 = 13.3848 μM.	SANGER
HOP-92	Growth Inhibition Assay	Inhibition of human HOP-92 cell growth in a cell viability assay, IC50 = 13.7996 μM.	SANGER
OE19	Growth Inhibition Assay	Inhibition of human OE19 cell growth in a cell viability assay, IC50 = 14.0075 μM.	SANGER
D-392MG	Growth Inhibition Assay	Inhibition of human D-392MG cell growth in a cell viability assay, IC50 = 14.1211 μM.	SANGER
A253	Growth Inhibition Assay	Inhibition of human A253 cell growth in a cell viability assay, IC50 = 14.225 μM.	SANGER
NCI-H1155	Growth Inhibition Assay	Inhibition of human NCI-H1155 cell growth in a cell viability assay, IC50 = 14.2747 μM.	SANGER
SNB75	Growth Inhibition Assay	Inhibition of human SNB75 cell growth in a cell viability assay, IC50 = 14.3893 μM.	SANGER
23132-87	Growth Inhibition Assay	Inhibition of human 23132-87 cell growth in a cell viability assay, IC50 = 14.8353 μM.	SANGER
Calu-3	Growth Inhibition Assay	Inhibition of human Calu-3 cell growth in a cell viability assay, IC50 = 14.8743 μM.	SANGER
CW-2	Growth Inhibition Assay	Inhibition of human CW-2 cell growth in a cell viability assay, IC50 = 15.0223 μM.	SANGER
COLO-679	Growth Inhibition Assay	Inhibition of human COLO-679 cell growth in a cell viability assay, IC50 = 15.1013 μM.	SANGER
NCI-SNU-5	Growth Inhibition Assay	Inhibition of human NCI-SNU-5 cell growth in a cell viability assay, IC50 = 15.5589 μM.	SANGER
AN3-CA	Growth Inhibition Assay	Inhibition of human AN3-CA cell growth in a cell viability assay, IC50 = 15.6468 μM.	SANGER
SF126	Growth Inhibition Assay	Inhibition of human SF126 cell growth in a cell viability assay, IC50 = 15.7285 μM.	SANGER
D-247MG	Growth Inhibition Assay	Inhibition of human D-247MG cell growth in a cell viability assay, IC50 = 15.8534 μM.	SANGER
UACC-62	Growth Inhibition Assay	Inhibition of human UACC-62 cell growth in a cell viability assay, IC50 = 15.966 μM.	SANGER
GP5d	Growth Inhibition Assay	Inhibition of human GP5d cell growth in a cell viability assay, IC50 = 16.1171 μM.	SANGER
HuO-3N1	Growth Inhibition Assay	Inhibition of human HuO-3N1 cell growth in a cell viability assay, IC50 = 16.2473 μM.	SANGER
NCI-H1092	Growth Inhibition Assay	Inhibition of human NCI-H1092 cell growth in a cell viability assay, IC50 = 16.6297 μM.	SANGER
HCC1187	Growth Inhibition Assay	Inhibition of human HCC1187 cell growth in a cell viability assay, IC50 = 16.6557 μM.	SANGER
G-402	Growth Inhibition Assay	Inhibition of human G-402 cell growth in a cell viability assay, IC50 = 16.8565 μM.	SANGER
HT55	Growth Inhibition Assay	Inhibition of human HT55 cell growth in a cell viability assay, IC50 = 16.8751 μM.	SANGER
NCI-H2009	Growth Inhibition Assay	Inhibition of human NCI-H2009 cell growth in a cell viability assay, IC50 = 16.9266 μM.	SANGER
SH-4	Growth Inhibition Assay	Inhibition of human SH-4 cell growth in a cell viability assay, IC50 = 16.992 μM.	SANGER
SW1783	Growth Inhibition Assay	Inhibition of human SW1783 cell growth in a cell viability assay, IC50 = 16.9998 μM.	SANGER
HT	Growth Inhibition Assay	Inhibition of human HT cell growth in a cell viability assay, IC50 = 17.1964 μM.	SANGER
CP66-MEL	Growth Inhibition Assay	Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50 = 17.301 μM.	SANGER
BEN	Growth Inhibition Assay	Inhibition of human BEN cell growth in a cell viability assay, IC50 = 17.5626 μM.	SANGER
HCC38	Growth Inhibition Assay	Inhibition of human HCC38 cell growth in a cell viability assay, IC50 = 17.7698 μM.	SANGER
LAN-6	Growth Inhibition Assay	Inhibition of human LAN-6 cell growth in a cell viability assay, IC50 = 17.8485 μM.	SANGER
RERF-LC-MS	Growth Inhibition Assay	Inhibition of human RERF-LC-MS cell growth in a cell viability assay, IC50 = 17.9129 μM.	SANGER
NCI-H1770	Growth Inhibition Assay	Inhibition of human NCI-H1770 cell growth in a cell viability assay, IC50 = 17.9491 μM.	SANGER
LCLC-103H	Growth Inhibition Assay	Inhibition of human LCLC-103H cell growth in a cell viability assay, IC50 = 18.051 μM.	SANGER
NCI-H520	Growth Inhibition Assay	Inhibition of human NCI-H520 cell growth in a cell viability assay, IC50 = 18.3282 μM.	SANGER
LU-65	Growth Inhibition Assay	Inhibition of human LU-65 cell growth in a cell viability assay, IC50 = 18.4043 μM.	SANGER
SK-MEL-3	Growth Inhibition Assay	Inhibition of human SK-MEL-3 cell growth in a cell viability assay, IC50 = 18.668 μM.	SANGER
LK-2	Growth Inhibition Assay	Inhibition of human LK-2 cell growth in a cell viability assay, IC50 = 18.7723 μM.	SANGER
PANC-08-13	Growth Inhibition Assay	Inhibition of human PANC-08-13 cell growth in a cell viability assay, IC50 = 18.7889 μM.	SANGER
NCI-H460	Growth Inhibition Assay	Inhibition of human NCI-H460 cell growth in a cell viability assay, IC50 = 18.8467 μM.	SANGER
COLO-684	Growth Inhibition Assay	Inhibition of human COLO-684 cell growth in a cell viability assay, IC50 = 18.9956 μM.	SANGER
RPMI-2650	Growth Inhibition Assay	Inhibition of human RPMI-2650 cell growth in a cell viability assay, IC50 = 19.012 μM.	SANGER
NY	Growth Inhibition Assay	Inhibition of human NY cell growth in a cell viability assay, IC50 = 19.1567 μM.	SANGER
NB7	Growth Inhibition Assay	Inhibition of human NB7 cell growth in a cell viability assay, IC50 = 19.1753 μM.	SANGER
NCI-H358	Growth Inhibition Assay	Inhibition of human NCI-H358 cell growth in a cell viability assay, IC50 = 19.2673 μM.	SANGER
MC116	Growth Inhibition Assay	Inhibition of human MC116 cell growth in a cell viability assay, IC50 = 19.533 μM.	SANGER
MS-1	Growth Inhibition Assay	Inhibition of human MS-1 cell growth in a cell viability assay, IC50 = 19.6103 μM.	SANGER
NCI-H82	Growth Inhibition Assay	Inhibition of human NCI-H82 cell growth in a cell viability assay, IC50 = 19.6878 μM.	SANGER
OCI-AML2	Growth Inhibition Assay	Inhibition of human OCI-AML2 cell growth in a cell viability assay, IC50 = 19.7032 μM.	SANGER
LS-123	Growth Inhibition Assay	Inhibition of human LS-123 cell growth in a cell viability assay, IC50 = 20.0194 μM.	SANGER
PC-14	Growth Inhibition Assay	Inhibition of human PC-14 cell growth in a cell viability assay, IC50 = 20.1834 μM.	SANGER
NCI-H1703	Growth Inhibition Assay	Inhibition of human NCI-H1703 cell growth in a cell viability assay, IC50 = 20.8173 μM.	SANGER
Calu-6	Growth Inhibition Assay	Inhibition of human Calu-6 cell growth in a cell viability assay, IC50 = 21.1005 μM.	SANGER
no-11	Growth Inhibition Assay	Inhibition of human no-11 cell growth in a cell viability assay, IC50 = 21.1602 μM.	SANGER
NCI-H727	Growth Inhibition Assay	Inhibition of human NCI-H727 cell growth in a cell viability assay, IC50 = 21.3493 μM.	SANGER
DSH1	Growth Inhibition Assay	Inhibition of human DSH1 cell growth in a cell viability assay, IC50 = 21.3879 μM.	SANGER
KYSE-140	Growth Inhibition Assay	Inhibition of human KYSE-140 cell growth in a cell viability assay, IC50 = 21.7271 μM.	SANGER
RH-1	Growth Inhibition Assay	Inhibition of human RH-1 cell growth in a cell viability assay, IC50 = 21.883 μM.	SANGER
HAL-01	Growth Inhibition Assay	Inhibition of human HAL-01 cell growth in a cell viability assay, IC50 = 22.0419 μM.	SANGER
RXF393	Growth Inhibition Assay	Inhibition of human RXF393 cell growth in a cell viability assay, IC50 = 22.2788 μM.	SANGER
LS-411N	Growth Inhibition Assay	Inhibition of human LS-411N cell growth in a cell viability assay, IC50 = 22.2869 μM.	SANGER
no-10	Growth Inhibition Assay	Inhibition of human no-10 cell growth in a cell viability assay, IC50 = 22.5004 μM.	SANGER
MKN7	Growth Inhibition Assay	Inhibition of human MKN7 cell growth in a cell viability assay, IC50 = 22.6869 μM.	SANGER
AU565	Growth Inhibition Assay	Inhibition of human AU565 cell growth in a cell viability assay, IC50 = 22.7478 μM.	SANGER
NUGC-3	Growth Inhibition Assay	Inhibition of human NUGC-3 cell growth in a cell viability assay, IC50 = 23.1199 μM.	SANGER
EW-16	Growth Inhibition Assay	Inhibition of human EW-16 cell growth in a cell viability assay, IC50 = 24.0926 μM.	SANGER
HCC70	Growth Inhibition Assay	Inhibition of human HCC70 cell growth in a cell viability assay, IC50 = 24.1323 μM.	SANGER
RPMI-8226	Growth Inhibition Assay	Inhibition of human RPMI-8226 cell growth in a cell viability assay, IC50 = 24.3155 μM.	SANGER
CFPAC-1	Growth Inhibition Assay	Inhibition of human CFPAC-1 cell growth in a cell viability assay, IC50 = 24.6272 μM.	SANGER
DoTc2-4510	Growth Inhibition Assay	Inhibition of human DoTc2-4510 cell growth in a cell viability assay, IC50 = 24.7575 μM.	SANGER
KNS-62	Growth Inhibition Assay	Inhibition of human KNS-62 cell growth in a cell viability assay, IC50 = 25.018 μM.	SANGER
SK-N-DZ	Growth Inhibition Assay	Inhibition of human SK-N-DZ cell growth in a cell viability assay, IC50 = 25.0904 μM.	SANGER
CAL-85-1	Growth Inhibition Assay	Inhibition of human CAL-85-1 cell growth in a cell viability assay, IC50 = 25.1544 μM.	SANGER
JVM-2	Growth Inhibition Assay	Inhibition of human JVM-2 cell growth in a cell viability assay, IC50 = 25.2122 μM.	SANGER
NCI-H2347	Growth Inhibition Assay	Inhibition of human NCI-H2347 cell growth in a cell viability assay, IC50 = 25.4248 μM.	SANGER
P30-OHK	Growth Inhibition Assay	Inhibition of human P30-OHK cell growth in a cell viability assay, IC50 = 25.6318 μM.	SANGER
SK-N-FI	Growth Inhibition Assay	Inhibition of human SK-N-FI cell growth in a cell viability assay, IC50 = 26.1162 μM.	SANGER
CAMA-1	Growth Inhibition Assay	Inhibition of human CAMA-1 cell growth in a cell viability assay, IC50 = 26.4876 μM.	SANGER
MHH-NB-11	Growth Inhibition Assay	Inhibition of human MHH-NB-11 cell growth in a cell viability assay, IC50 = 26.5851 μM.	SANGER
IST-MEL1	Growth Inhibition Assay	Inhibition of human IST-MEL1 cell growth in a cell viability assay, IC50 = 26.7177 μM.	SANGER
KARPAS-299	Growth Inhibition Assay	Inhibition of human KARPAS-299 cell growth in a cell viability assay, IC50 = 27.4702 μM.	SANGER
TE-11	Growth Inhibition Assay	Inhibition of human TE-11 cell growth in a cell viability assay, IC50 = 27.7342 μM.	SANGER
769-P	Growth Inhibition Assay	Inhibition of human 769-P cell growth in a cell viability assay, IC50 = 28.4533 μM.	SANGER
CAL-72	Growth Inhibition Assay	Inhibition of human CAL-72 cell growth in a cell viability assay, IC50 = 28.5561 μM.	SANGER
NCI-H2342	Growth Inhibition Assay	Inhibition of human NCI-H2342 cell growth in a cell viability assay, IC50 = 29.3803 μM.	SANGER
NCI-H1651	Growth Inhibition Assay	Inhibition of human NCI-H1651 cell growth in a cell viability assay, IC50 = 29.8503 μM.	SANGER
OE33	Growth Inhibition Assay	Inhibition of human OE33 cell growth in a cell viability assay, IC50 = 30.1342 μM.	SANGER
HuP-T4	Growth Inhibition Assay	Inhibition of human HuP-T4 cell growth in a cell viability assay, IC50 = 31.4837 μM.	SANGER
U-118-MG	Growth Inhibition Assay	Inhibition of human U-118-MG cell growth in a cell viability assay, IC50 = 32.5441 μM.	SANGER
SN12C	Growth Inhibition Assay	Inhibition of human SN12C cell growth in a cell viability assay, IC50 = 32.8815 μM.	SANGER
TE-5	Growth Inhibition Assay	Inhibition of human TE-5 cell growth in a cell viability assay, IC50 = 33.1368 μM.	SANGER
KM-H2	Growth Inhibition Assay	Inhibition of human KM-H2 cell growth in a cell viability assay, IC50 = 33.1699 μM.	SANGER
OVCAR-3	Growth Inhibition Assay	Inhibition of human OVCAR-3 cell growth in a cell viability assay, IC50 = 33.4127 μM.	SANGER
NCI-H1304	Growth Inhibition Assay	Inhibition of human NCI-H1304 cell growth in a cell viability assay, IC50 = 33.6036 μM.	SANGER
LU-135	Growth Inhibition Assay	Inhibition of human LU-135 cell growth in a cell viability assay, IC50 = 33.7086 μM.	SANGER
S-117	Growth Inhibition Assay	Inhibition of human S-117 cell growth in a cell viability assay, IC50 = 33.7286 μM.	SANGER
NCI-H1755	Growth Inhibition Assay	Inhibition of human NCI-H1755 cell growth in a cell viability assay, IC50 = 33.811 μM.	SANGER
SK-OV-3	Growth Inhibition Assay	Inhibition of human SK-OV-3 cell growth in a cell viability assay, IC50 = 33.8854 μM.	SANGER
RCC10RGB	Growth Inhibition Assay	Inhibition of human RCC10RGB cell growth in a cell viability assay, IC50 = 33.9433 μM.	SANGER
COLO-680N	Growth Inhibition Assay	Inhibition of human COLO-680N cell growth in a cell viability assay, IC50 = 34.1397 μM.	SANGER
KURAMOCHI	Growth Inhibition Assay	Inhibition of human KURAMOCHI cell growth in a cell viability assay, IC50 = 34.6425 μM.	SANGER
NCI-H661	Growth Inhibition Assay	Inhibition of human NCI-H661 cell growth in a cell viability assay, IC50 = 34.8448 μM.	SANGER
YAPC	Growth Inhibition Assay	Inhibition of human YAPC cell growth in a cell viability assay, IC50 = 35.9533 μM.	SANGER
NCI-H526	Growth Inhibition Assay	Inhibition of human NCI-H526 cell growth in a cell viability assay, IC50 = 37.2772 μM.	SANGER
A498	Growth Inhibition Assay	Inhibition of human A498 cell growth in a cell viability assay, IC50 = 38.0954 μM.	SANGER
VMRC-RCZ	Growth Inhibition Assay	Inhibition of human VMRC-RCZ cell growth in a cell viability assay, IC50 = 39.0054 μM.	SANGER
HCT-116	Growth Inhibition Assay	Inhibition of human HCT-116 cell growth in a cell viability assay, IC50 = 39.058 μM.	SANGER
COLO-320-HSR	Growth Inhibition Assay	Inhibition of human COLO-320-HSR cell growth in a cell viability assay, IC50 = 40.041 μM.	SANGER
OAW-42	Growth Inhibition Assay	Inhibition of human OAW-42 cell growth in a cell viability assay, IC50 = 40.0542 μM.	SANGER
SK-MEL-1	Growth Inhibition Assay	Inhibition of human SK-MEL-1 cell growth in a cell viability assay, IC50 = 40.2927 μM.	SANGER
IST-MES1	Growth Inhibition Assay	Inhibition of human IST-MES1 cell growth in a cell viability assay, IC50 = 40.7653 μM.	SANGER
CP50-MEL-B	Growth Inhibition Assay	Inhibition of human CP50-MEL-B cell growth in a cell viability assay, IC50 = 41.0797 μM.	SANGER
RMG-I	Growth Inhibition Assay	Inhibition of human RMG-I cell growth in a cell viability assay, IC50 = 42.4921 μM.	SANGER
D-336MG	Growth Inhibition Assay	Inhibition of human D-336MG cell growth in a cell viability assay, IC50 = 43.1152 μM.	SANGER
SHP-77	Growth Inhibition Assay	Inhibition of human SHP-77 cell growth in a cell viability assay, IC50 = 43.1828 μM.	SANGER
SW872	Growth Inhibition Assay	Inhibition of human SW872 cell growth in a cell viability assay, IC50 = 43.2123 μM.	SANGER
DBTRG-05MG	Growth Inhibition Assay	Inhibition of human DBTRG-05MG cell growth in a cell viability assay, IC50 = 44.6996 μM.	SANGER
COLO-678	Growth Inhibition Assay	Inhibition of human COLO-678 cell growth in a cell viability assay, IC50 = 45.7032 μM.	SANGER
EGI-1	Growth Inhibition Assay	Inhibition of human EGI-1 cell growth in a cell viability assay, IC50 = 47.1833 μM.	SANGER
KYSE-70	Growth Inhibition Assay	Inhibition of human KYSE-70 cell growth in a cell viability assay, IC50 = 47.7222 μM.	SANGER
BALL-1	Growth Inhibition Assay	Inhibition of human BALL-1 cell growth in a cell viability assay, IC50 = 47.8254 μM.	SANGER
MDA-MB-361	Growth Inhibition Assay	Inhibition of human MDA-MB-361 cell growth in a cell viability assay, IC50 = 48.046 μM.	SANGER
NCI-H1838	Growth Inhibition Assay	Inhibition of human NCI-H1838 cell growth in a cell viability assay, IC50 = 48.3458 μM.	SANGER
NCI-H1573	Growth Inhibition Assay	Inhibition of human NCI-H1573 cell growth in a cell viability assay, IC50 = 48.6785 μM.	SANGER
HCC1395	Growth Inhibition Assay	Inhibition of human HCC1395 cell growth in a cell viability assay, IC50 = 48.9919 μM.	SANGER
NCI-H2291	Growth Inhibition Assay	Inhibition of human NCI-H2291 cell growth in a cell viability assay, IC50 = 49.5988 μM.	SANGER
RH-18	Growth Inhibition Assay	Inhibition of human RH-18 cell growth in a cell viability assay, IC50 = 50.0884 μM.	SANGER
LU-99A	Growth Inhibition Assay	Inhibition of human LU-99A cell growth in a cell viability assay, IC50 = 51.6128 μM.	SANGER
NCI-H1693	Growth Inhibition Assay	Inhibition of human NCI-H1693 cell growth in a cell viability assay, IC50 = 52.0101 μM.	SANGER
TE-12	Growth Inhibition Assay	Inhibition of human TE-12 cell growth in a cell viability assay, IC50 = 52.3319 μM.	SANGER
MCF7	Growth Inhibition Assay	Inhibition of human MCF7 cell growth in a cell viability assay, IC50 = 52.8847 μM.	SANGER
MMAC-SF	Growth Inhibition Assay	Inhibition of human MMAC-SF cell growth in a cell viability assay, IC50 = 53.558 μM.	SANGER
COLO-792	Growth Inhibition Assay	Inhibition of human COLO-792 cell growth in a cell viability assay, IC50 = 53.686 μM.	SANGER
MKN28	Growth Inhibition Assay	Inhibition of human MKN28 cell growth in a cell viability assay, IC50 = 54.4187 μM.	SANGER
PA-1	Growth Inhibition Assay	Inhibition of human PA-1 cell growth in a cell viability assay, IC50 = 54.6183 μM.	SANGER
SW1088	Growth Inhibition Assay	Inhibition of human SW1088 cell growth in a cell viability assay, IC50 = 56.932 μM.	SANGER
NB13	Growth Inhibition Assay	Inhibition of human NB13 cell growth in a cell viability assay, IC50 = 57.5442 μM.	SANGER
KLE	Growth Inhibition Assay	Inhibition of human KLE cell growth in a cell viability assay, IC50 = 58.3946 μM.	SANGER
KYSE-180	Growth Inhibition Assay	Inhibition of human KYSE-180 cell growth in a cell viability assay, IC50 = 58.7833 μM.	SANGER
NCI-H1355	Growth Inhibition Assay	Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50 = 59.2853 μM.	SANGER
LB2518-MEL	Growth Inhibition Assay	Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50 = 59.8763 μM.	SANGER
MFE-280	Growth Inhibition Assay	Inhibition of human MFE-280 cell growth in a cell viability assay, IC50 = 60.9372 μM.	SANGER
ALL-PO	Growth Inhibition Assay	Inhibition of human ALL-PO cell growth in a cell viability assay, IC50 = 61.2463 μM.	SANGER
NCI-H1650	Growth Inhibition Assay	Inhibition of human NCI-H1650 cell growth in a cell viability assay, IC50 = 62.3298 μM.	SANGER
HCC2218	Growth Inhibition Assay	Inhibition of human HCC2218 cell growth in a cell viability assay, IC50 = 63.3887 μM.	SANGER
UMC-11	Growth Inhibition Assay	Inhibition of human UMC-11 cell growth in a cell viability assay, IC50 = 65.4468 μM.	SANGER
CCRF-CEM	Growth Inhibition Assay	Inhibition of human CCRF-CEM cell growth in a cell viability assay, IC50 = 65.4541 μM.	SANGER
NCI-H2030	Growth Inhibition Assay	Inhibition of human NCI-H2030 cell growth in a cell viability assay, IC50 = 66.5634 μM.	SANGER
EKVX	Growth Inhibition Assay	Inhibition of human EKVX cell growth in a cell viability assay, IC50 = 68.1743 μM.	SANGER
MSTO-211H	Growth Inhibition Assay	Inhibition of human MSTO-211H cell growth in a cell viability assay, IC50 = 68.4406 μM.	SANGER
A2058	Growth Inhibition Assay	Inhibition of human A2058 cell growth in a cell viability assay, IC50 = 68.4821 μM.	SANGER
MG-63	Growth Inhibition Assay	Inhibition of human MG-63 cell growth in a cell viability assay, IC50 = 69.7565 μM.	SANGER
NCI-H630	Growth Inhibition Assay	Inhibition of human NCI-H630 cell growth in a cell viability assay, IC50 = 70.4213 μM.	SANGER
HCC1569	Growth Inhibition Assay	Inhibition of human HCC1569 cell growth in a cell viability assay, IC50 = 71.0089 μM.	SANGER
Capan-2	Growth Inhibition Assay	Inhibition of human Capan-2 cell growth in a cell viability assay, IC50 = 71.0614 μM.	SANGER
NCI-H2126	Growth Inhibition Assay	Inhibition of human NCI-H2126 cell growth in a cell viability assay, IC50 = 73.4725 μM.	SANGER
OS-RC-2	Growth Inhibition Assay	Inhibition of human OS-RC-2 cell growth in a cell viability assay, IC50 = 73.6568 μM.	SANGER
COLO-741	Growth Inhibition Assay	Inhibition of human COLO-741 cell growth in a cell viability assay, IC50 = 78.9707 μM.	SANGER
ES6	Growth Inhibition Assay	Inhibition of human ES6 cell growth in a cell viability assay, IC50 = 79.1431 μM.	SANGER
VA-ES-BJ	Growth Inhibition Assay	Inhibition of human VA-ES-BJ cell growth in a cell viability assay, IC50 = 80.7811 μM.	SANGER
Mewo	Growth Inhibition Assay	Inhibition of human Mewo cell growth in a cell viability assay, IC50 = 80.9653 μM.	SANGER
EW-13	Growth Inhibition Assay	Inhibition of human EW-13 cell growth in a cell viability assay, IC50 = 82.0084 μM.	SANGER
SK-MEL-30	Growth Inhibition Assay	Inhibition of human SK-MEL-30 cell growth in a cell viability assay, IC50 = 82.0855 μM.	SANGER
MFH-ino	Growth Inhibition Assay	Inhibition of human MFH-ino cell growth in a cell viability assay, IC50 = 83.5284 μM.	SANGER
SW1116	Growth Inhibition Assay	Inhibition of human SW1116 cell growth in a cell viability assay, IC50 = 85.4856 μM.	SANGER
LS-513	Growth Inhibition Assay	Inhibition of human LS-513 cell growth in a cell viability assay, IC50 = 88.7976 μM.	SANGER
SW1463	Growth Inhibition Assay	Inhibition of human SW1463 cell growth in a cell viability assay, IC50 = 91.6713 μM.	SANGER
WM-115	Growth Inhibition Assay	Inhibition of human WM-115 cell growth in a cell viability assay, IC50 = 92.9267 μM.	SANGER
A2780	Growth Inhibition Assay	Inhibition of human A2780 cell growth in a cell viability assay, IC50 = 93.6595 μM.	SANGER
PANC-10-05	Growth Inhibition Assay	Inhibition of human PANC-10-05 cell growth in a cell viability assay, IC50 = 93.9708 μM.	SANGER
NCI-H1623	Growth Inhibition Assay	Inhibition of human NCI-H1623 cell growth in a cell viability assay, IC50 = 95.7976 μM.	SANGER
COLO-668	Growth Inhibition Assay	Inhibition of human COLO-668 cell growth in a cell viability assay, IC50 = 96.9094 μM.	SANGER
HCC2157	Growth Inhibition Assay	Inhibition of human HCC2157 cell growth in a cell viability assay, IC50 = 97.0782 μM.	SANGER
OC-314	Growth Inhibition Assay	Inhibition of human OC-314 cell growth in a cell viability assay, IC50 = 98.494 μM.	SANGER
SK-MEL-24	Growth Inhibition Assay	Inhibition of human SK-MEL-24 cell growth in a cell viability assay, IC50 = 99.3301 μM.	SANGER
HCC2998	Growth Inhibition Assay	Inhibition of human HCC2998 cell growth in a cell viability assay, IC50 = 101.05 μM.	SANGER
NCI-H2170	Growth Inhibition Assay	Inhibition of human NCI-H2170 cell growth in a cell viability assay, IC50 = 102.933 μM.	SANGER
HT-1197	Growth Inhibition Assay	Inhibition of human HT-1197 cell growth in a cell viability assay, IC50 = 103.494 μM.	SANGER
HCT-15	Growth Inhibition Assay	Inhibition of human HCT-15 cell growth in a cell viability assay, IC50 = 105.399 μM.	SANGER
MKN45	Growth Inhibition Assay	Inhibition of human MKN45 cell growth in a cell viability assay, IC50 = 105.597 μM.	SANGER
SW13	Growth Inhibition Assay	Inhibition of human SW13 cell growth in a cell viability assay, IC50 = 105.968 μM.	SANGER
RO82-W-1	Growth Inhibition Assay	Inhibition of human RO82-W-1 cell growth in a cell viability assay, IC50 = 107.765 μM.	SANGER
JAR	Growth Inhibition Assay	Inhibition of human JAR cell growth in a cell viability assay, IC50 = 108.694 μM.	SANGER
ESS-1	Growth Inhibition Assay	Inhibition of human ESS-1 cell growth in a cell viability assay, IC50 = 114.118 μM.	SANGER
LS-1034	Growth Inhibition Assay	Inhibition of human LS-1034 cell growth in a cell viability assay, IC50 = 118.609 μM.	SANGER
BFTC-909	Growth Inhibition Assay	Inhibition of human BFTC-909 cell growth in a cell viability assay, IC50 = 120.485 μM.	SANGER
TGBC24TKB	Growth Inhibition Assay	Inhibition of human TGBC24TKB cell growth in a cell viability assay, IC50 = 124.298 μM.	SANGER
T-24	Growth Inhibition Assay	Inhibition of human T-24 cell growth in a cell viability assay, IC50 = 125.66 μM.	SANGER
J82	Growth Inhibition Assay	Inhibition of human J82 cell growth in a cell viability assay, IC50 = 129.014 μM.	SANGER
AM-38	Growth Inhibition Assay	Inhibition of human AM-38 cell growth in a cell viability assay, IC50 = 129.407 μM.	SANGER
MDA-MB-453	Growth Inhibition Assay	Inhibition of human MDA-MB-453 cell growth in a cell viability assay, IC50 = 130.177 μM.	SANGER
U-2-OS	Growth Inhibition Assay	Inhibition of human U-2-OS cell growth in a cell viability assay, IC50 = 130.803 μM.	SANGER
NCI-H1666	Growth Inhibition Assay	Inhibition of human NCI-H1666 cell growth in a cell viability assay, IC50 = 131.615 μM.	SANGER
DOHH-2	Growth Inhibition Assay	Inhibition of human DOHH-2 cell growth in a cell viability assay, IC50 = 131.981 μM.	SANGER
U031	Growth Inhibition Assay	Inhibition of human U031 cell growth in a cell viability assay, IC50 = 139.51 μM.	SANGER
A673	Growth Inhibition Assay	Inhibition of human A673 cell growth in a cell viability assay, IC50 = 140.714 μM.	SANGER
NCI-H1793	Growth Inhibition Assay	Inhibition of human NCI-H1793 cell growth in a cell viability assay, IC50 = 142.235 μM.	SANGER
BxPC-3	Growth Inhibition Assay	Inhibition of human BxPC-3 cell growth in a cell viability assay, IC50 = 144.449 μM.	SANGER
SW837	Growth Inhibition Assay	Inhibition of human SW837 cell growth in a cell viability assay, IC50 = 145.887 μM.	SANGER
HT-29	Growth Inhibition Assay	Inhibition of human HT-29 cell growth in a cell viability assay, IC50 = 148.287 μM.	SANGER
MZ7-mel	Growth Inhibition Assay	Inhibition of human MZ7-mel cell growth in a cell viability assay, IC50 = 149.332 μM.	SANGER
SW620	Growth Inhibition Assay	Inhibition of human SW620 cell growth in a cell viability assay, IC50 = 152.783 μM.	SANGER
GAK	Growth Inhibition Assay	Inhibition of human GAK cell growth in a cell viability assay, IC50 = 157.274 μM.	SANGER
CAS-1	Growth Inhibition Assay	Inhibition of human CAS-1 cell growth in a cell viability assay, IC50 = 161.861 μM.	SANGER
HuP-T3	Growth Inhibition Assay	Inhibition of human HuP-T3 cell growth in a cell viability assay, IC50 = 164.025 μM.	SANGER
K-562	Growth Inhibition Assay	Inhibition of human K-562 cell growth in a cell viability assay, IC50 = 166.999 μM.	SANGER
KP-4	Growth Inhibition Assay	Inhibition of human KP-4 cell growth in a cell viability assay, IC50 = 176.133 μM.	SANGER
LB771-HNC	Growth Inhibition Assay	Inhibition of human LB771-HNC cell growth in a cell viability assay, IC50 = 177.514 μM.	SANGER
BCPAP	Growth Inhibition Assay	Inhibition of human BCPAP cell growth in a cell viability assay, IC50 = 178.122 μM.	SANGER
NCI-N87	Growth Inhibition Assay	Inhibition of human NCI-N87 cell growth in a cell viability assay, IC50 = 181.488 μM.	SANGER
H-EMC-SS	Growth Inhibition Assay	Inhibition of human H-EMC-SS cell growth in a cell viability assay, IC50 = 202.692 μM.	SANGER
D-263MG	Growth Inhibition Assay	Inhibition of human D-263MG cell growth in a cell viability assay, IC50 = 207.067 μM.	SANGER
LB373-MEL-D	Growth Inhibition Assay	Inhibition of human LB373-MEL-D cell growth in a cell viability assay, IC50 = 207.487 μM.	SANGER
SF295	Growth Inhibition Assay	Inhibition of human SF295 cell growth in a cell viability assay, IC50 = 212.709 μM.	SANGER
BT-20	Growth Inhibition Assay	Inhibition of human BT-20 cell growth in a cell viability assay, IC50 = 214.977 μM.	SANGER
SK-LMS-1	Growth Inhibition Assay	Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50 = 217.946 μM.	SANGER
HCE-T	Growth Inhibition Assay	Inhibition of human HCE-T cell growth in a cell viability assay, IC50 = 220.414 μM.	SANGER
NCI-H522	Growth Inhibition Assay	Inhibition of human NCI-H522 cell growth in a cell viability assay, IC50 = 220.593 μM.	SANGER
DK-MG	Growth Inhibition Assay	Inhibition of human DK-MG cell growth in a cell viability assay, IC50 = 228.077 μM.	SANGER
HDLM-2	Growth Inhibition Assay	Inhibition of human HDLM-2 cell growth in a cell viability assay, IC50 = 228.889 μM.	SANGER
RPMI-8866	Growth Inhibition Assay	Inhibition of human RPMI-8866 cell growth in a cell viability assay, IC50 = 234.422 μM.	SANGER
SBC-5	Growth Inhibition Assay	Inhibition of human SBC-5 cell growth in a cell viability assay, IC50 = 235.457 μM.	SANGER
NCI-H441	Growth Inhibition Assay	Inhibition of human NCI-H441 cell growth in a cell viability assay, IC50 = 241.801 μM.	SANGER
HCC1937	Growth Inhibition Assay	Inhibition of human HCC1937 cell growth in a cell viability assay, IC50 = 244.754 μM.	SANGER
CAKI-1	Growth Inhibition Assay	Inhibition of human CAKI-1 cell growth in a cell viability assay, IC50 = 256.034 μM.	SANGER
SW1417	Growth Inhibition Assay	Inhibition of human SW1417 cell growth in a cell viability assay, IC50 = 259.036 μM.	SANGER
ONS-76	Growth Inhibition Assay	Inhibition of human ONS-76 cell growth in a cell viability assay, IC50 = 265.052 μM.	SANGER
HCC1419	Growth Inhibition Assay	Inhibition of human HCC1419 cell growth in a cell viability assay, IC50 = 266.025 μM.	SANGER
A4-Fuk	Growth Inhibition Assay	Inhibition of human A4-Fuk cell growth in a cell viability assay, IC50 = 266.655 μM.	SANGER
SW1990	Growth Inhibition Assay	Inhibition of human SW1990 cell growth in a cell viability assay, IC50 = 270.481 μM.	SANGER
EFO-21	Growth Inhibition Assay	Inhibition of human EFO-21 cell growth in a cell viability assay, IC50 = 279.176 μM.	SANGER
COR-L105	Growth Inhibition Assay	Inhibition of human COR-L105 cell growth in a cell viability assay, IC50 = 303.984 μM.	SANGER
AsPC-1	Growth Inhibition Assay	Inhibition of human AsPC-1 cell growth in a cell viability assay, IC50 = 316.889 μM.	SANGER
T84	Growth Inhibition Assay	Inhibition of human T84 cell growth in a cell viability assay, IC50 = 325.443 μM.	SANGER
ABC-1	Growth Inhibition Assay	Inhibition of human ABC-1 cell growth in a cell viability assay, IC50 = 335.897 μM.	SANGER
NCI-H226	Growth Inhibition Assay	Inhibition of human NCI-H226 cell growth in a cell viability assay, IC50 = 366.683 μM.	SANGER
UACC-893	Growth Inhibition Assay	Inhibition of human UACC-893 cell growth in a cell viability assay, IC50 = 368.948 μM.	SANGER
OAW-28	Growth Inhibition Assay	Inhibition of human OAW-28 cell growth in a cell viability assay, IC50 = 383.493 μM.	SANGER
NMC-G1	Growth Inhibition Assay	Inhibition of human NMC-G1 cell growth in a cell viability assay, IC50 = 395.947 μM.	SANGER
NCI-H1563	Growth Inhibition Assay	Inhibition of human NCI-H1563 cell growth in a cell viability assay, IC50 = 398.096 μM.	SANGER
SW900	Growth Inhibition Assay	Inhibition of human SW900 cell growth in a cell viability assay, IC50 = 401.326 μM.	SANGER
SW948	Growth Inhibition Assay	Inhibition of human SW948 cell growth in a cell viability assay, IC50 = 411.094 μM.	SANGER
CAPAN-1	Growth Inhibition Assay	Inhibition of human CAPAN-1 cell growth in a cell viability assay, IC50 = 411.292 μM.	SANGER
UACC-257	Growth Inhibition Assay	Inhibition of human UACC-257 cell growth in a cell viability assay, IC50 = 433.155 μM.	SANGER
ZR-75-30	Growth Inhibition Assay	Inhibition of human ZR-75-30 cell growth in a cell viability assay, IC50 = 449.934 μM.	SANGER
NCI-H1993	Growth Inhibition Assay	Inhibition of human NCI-H1993 cell growth in a cell viability assay, IC50 = 480.264 μM.	SANGER
LB996-RCC	Growth Inhibition Assay	Inhibition of human LB996-RCC cell growth in a cell viability assay, IC50 = 495.241 μM.	SANGER
L-428	Growth Inhibition Assay	Inhibition of human L-428 cell growth in a cell viability assay, IC50 = 554.78 μM.	SANGER
C3A	Growth Inhibition Assay	Inhibition of human C3A cell growth in a cell viability assay, IC50 = 563.78 μM.	SANGER
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Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro
In vitro	BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]
Kinase Assay	Protein kinase assays
Kinase Assay	Purified His6–RSK1, His6–RSK2 or GST–RSK2^{1–389:S381E} (1–2 units/mL) are assayed for 10 min at 30 °C in a 50 μL assay mixture in Buffer A containing 30 μM substrate peptide (KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK), 10 mM magnesium acetate and 100 μM of [γ-³²P]ATP. Reactions are terminated and analysed as described previously. The amount of enzyme that catalysed the phosphorylation of 1 nmol of substrate peptide in 1 min is termed one unit. In order to assay RSK and MSK1 in HEK-293 or Rat-2 cell lysates, these kinases are immunoprecipitated from the cell lysates (0.1 mg of lysate protein for RSK and 0.3 mg for MSK1) and for RSK assays the immunoprecipitates are washed twice with Buffer A containing 1 mM ATP and twice with Buffer A prior to the assay, as a precaution to ensure dissociation of BI-D1870 from the RSK isoforms.
Experimental Result Images	Methods	Biomarkers	Images	PMID
	Western blot	p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK IRF4 / MYC / MCL-1 / PARP p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK IRF4 / MYC / MCL-1 / PARP		17040210
	Immunofluorescence	PDCD4 / F-actin PDCD4 / F-actin		25002506
	Growth inhibition assay	Cell viability Cell viability		28415756

References

Chemical Information & Solubility

Molecular Weight	391.42	Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1	SDF	Download BI-D1870 SDF
Smiles	CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 78 mg/mL ( (199.27 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo Batch: Add solvents to the product individually and in order.				In vivo Formulation Calculator
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.250mg/ml (3.19mM)	Taking the 1 mL working solution as an example, add 50 μL 25 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

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Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?

Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

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