BI-D1870

Catalog No.S2843

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Cited by 7 Publications

Neurourol Urodyn, 2019, 38(6):1504-1516

PubMed: 31033016 ( click the link to review the publication )

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

4 Customer Reviews

Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

(g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.
HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	Mlu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTBwMEO1PEDPxE1?	Mn\mV2FPT0WU
H9	MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTBwME[wNVkh\|ryP	MUnTRW5ITVJ?
KARPAS-45	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXHJR\|UxRTBwMU[1NlUh\|ryP	Mn:5V2FPT0WU
NCI-H720	NYX6RphxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUWxTXc4UUN3ME2wMlE4OTl2IN88US=>	NVnBd5lMW0GQR1XS
CTV-1	MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnjuTWM2OD1yLkS3PFczKM7:TR?=	NUftSohvW0GQR1XS
DU-4475	Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUnJR\|UxRTBwNUC0NVch\|ryP	M1;4bHNCVkeHUh?=
A172	NF;l[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE[3[YJKSzVyPUCuOVE4ODVizszN	M1vydnNCVkeHUh?=
EW-18	M3y1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTBwNkKyNVEh\|ryP	MWfTRW5ITVJ?
KU812	NXH5UlQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlWyTWM2OD1yLk[yOlI{KM7:TR?=	Ml7tV2FPT0WU
KP-N-YS	M1TJT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXz6T3FiUUN3ME2wMlY5OjJ\|IN88US=>	MojRV2FPT0WU
SBC-1	M2LDUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTmVndKSzVyPUCuOlk2OjRizszN	NUC2R3FtW0GQR1XS
ECC10	MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3XUV2lEPTB;MD63NFA6PCEQvF2=	MUHTRW5ITVJ?
GAMG	M2\zUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTBwN{S3NVch\|ryP	NWC0ZoFVW0GQR1XS
NCI-H209	M2Hubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3;MSGlEPTB;MD63OlgzKM7:TR?=	M{PTc3NCVkeHUh?=
MC-IXC	NULBc3JXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUW5ZmltUUN3ME2wMlc6PTh7IN88US=>	NX:1XIpSW0GQR1XS
HSC-3	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2XZTmlEPTB;MD64NVc3QSEQvF2=	NUXIb\|FFW0GQR1XS
IST-SL1	NEjpd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2nzWWlEPTB;MD64OFU4PCEQvF2=	MYnTRW5ITVJ?
LU-139	NFzSclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUnpW4Q6UUN3ME2wMlg1QTV6IN88US=>	MXfTRW5ITVJ?
ML-2	NEH5e25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTBwOEW1O\|Uh\|ryP	NEHFcYJUSU6JRWK=
CAL-62	M4nNOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWHJR\|UxRTBwOEixOVIh\|ryP	NYqwdoMxW0GQR1XS
HL-60	NWTzNYhIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnfTTWM2OD1yLki4N\|YzKM7:TR?=	NXX5V4c5W0GQR1XS
KY821	M3rhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYjPfYl3UUN3ME2wMlg5QDF{IN88US=>	MoXOV2FPT0WU
ES7	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYfJR\|UxRTBwOUG2NFch\|ryP	M4nzZnNCVkeHUh?=
MV-4-11	M2L4c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnTmTWM2OD1yLkm3PFk4KM7:TR?=	NE\kZ2hUSU6JRWK=
Daoy	NHH4fXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY\nUZQ{UUN3ME2wMlk5PzZ5IN88US=>	NHznd2ZUSU6JRWK=
EoL-1-cell	M2XKeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHQTWM2OD1zLkCxPFc5KM7:TR?=	Moq2V2FPT0WU
TGW	M2TJS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlPXTWM2OD1zLkC1NVI1KM7:TR?=	MoLBV2FPT0WU
LAMA-84	NGfIOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTFwMUK3PVQh\|ryP	MVnTRW5ITVJ?
KOSC-2	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XseWlEPTB;MT6xN\|M5PSEQvF2=	MXPTRW5ITVJ?
A549	M1nkdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7wUWxPUUN3ME2xMlMxQTV3IN88US=>	MoqwV2FPT0WU
CTB-1	NG\2V2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYCxd4ppUUN3ME2xMlQ1Pjd7IN88US=>	MkLLV2FPT0WU
NCI-H292	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVrnSldJUUN3ME2xMlQ3ODZ7IN88US=>	NV6zbow4W0GQR1XS
LoVo	NEjTO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEnle5FKSzVyPUGuOFY4PTVizszN	NHfzeJlUSU6JRWK=
BFTC-905	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVTLOpdpUUN3ME2xMlU3OzN{IN88US=>	Mk\yV2FPT0WU
BE-13	M4PoZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml23TWM2OD1zLkW4O\|A6KM7:TR?=	NIXZUYVUSU6JRWK=
KE-37	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRTFwNUm0O\|gh\|ryP	NHnmOIFUSU6JRWK=
HN	NXHMSHdKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX;JR\|UxRTFwNkGzOlgh\|ryP	M{KxXnNCVkeHUh?=
A3-KAW	NID0VmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn3qTWM2OD1zLk[yPFM1KM7:TR?=	MYnTRW5ITVJ?
NEC8	NFGw[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGSxTZRKSzVyPUGuO\|AyOTVizszN	NIjodphUSU6JRWK=
Ramos-2G6-4C10	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlS0TWM2OD1zLkewOFQ1KM7:TR?=	NYrieXpJW0GQR1XS
NB10	M4n6NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkezTWM2OD1zLke3OlMh\|ryP	M3OxVnNCVkeHUh?=
NBsusSR	M3LPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXfJR\|UxRTFwOEK5OlEh\|ryP	M3jJOXNCVkeHUh?=
ES4	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXTGbYhjUUN3ME2xMlg2OTR\|IN88US=>	MkfhV2FPT0WU
ES8	NVnlXJFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXvJR\|UxRTFwOEe3NlQh\|ryP	MXLTRW5ITVJ?
CHL-1	NWmyb5hyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWfJR\|UxRTFwOUW3PVIh\|ryP	M1fafXNCVkeHUh?=
NCI-H2029	NGPmUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2HGc2lEPTB;MT65O\|I1OSEQvF2=	M2jMXXNCVkeHUh?=
YKG-1	NELrb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXL4OpB1UUN3ME2xMlk5PDN{IN88US=>	MUjTRW5ITVJ?
BV-173	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFPOO2FKSzVyPUGuPVg3PjZizszN	MVfTRW5ITVJ?
697	NFvKb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{P6NmlEPTB;Mj6wNlIzQCEQvF2=	NF;VenFUSU6JRWK=
SK-NEP-1	NGD3ZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTJwMES0JO69VQ>?	MorlV2FPT0WU
LOXIMVI	M3PQZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTJwMES0N\|Qh\|ryP	MWLTRW5ITVJ?
QIMR-WIL	NF63fYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn:1TWM2OD1{LkC3PFQ6KM7:TR?=	M3v2OHNCVkeHUh?=
DU-145	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF73SItKSzVyPUKuNVExPTZizszN	MlyyV2FPT0WU
NB14	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mkj1TWM2OD1{LkGxN\|IyKM7:TR?=	MoDUV2FPT0WU
G-361	MoTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTJwMUKyNUDPxE1?	MWjTRW5ITVJ?
BPH-1	NVqwdowzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV\JR\|UxRTJwMUK5OVch\|ryP	NFLPZW5USU6JRWK=
KYSE-150	NYCw[2RpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVe1SGE3UUN3ME2yMlE2OjN2IN88US=>	M3nRUnNCVkeHUh?=
HMV-II	M4HNN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTJwMU[2N\|Mh\|ryP	NX3iSmNJW0GQR1XS
TE-9	MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3rY[mlEPTB;Mj6xO\|M4PiEQvF2=	M3;Vd3NCVkeHUh?=
8-MG-BA	MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF\QR4tKSzVyPUKuNlM1PjFizszN	MVLTRW5ITVJ?
ES5	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3fx[GlEPTB;Mj6yN\|Y{OyEQvF2=	NVvBOVBkW0GQR1XS
D-283MED	M4jmV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF25cXpKSzVyPUKuNlM3QTVizszN	NYLRempjW0GQR1XS
SK-N-AS	NYnJdIZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\KfZBoUUN3ME2yMlI6ODV7IN88US=>	MlXCV2FPT0WU
SW1710	MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVLBNlAzUUN3ME2yMlMxPjZzIN88US=>	NUfDTY1YW0GQR1XS
GCT	MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTJwM{GzOVgh\|ryP	NYXYXYNbW0GQR1XS
AGS	NV\yW294T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnzqTWM2OD1{LkO0OFA1KM7:TR?=	MkjBV2FPT0WU
HuO9	NILjb3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXvJR\|UxRTJwM{[4NlQh\|ryP	M4TJcXNCVkeHUh?=
MN-60	MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rw[2lEPTB;Mj60OFg5OyEQvF2=	M{nzR3NCVkeHUh?=
NB6	NW\jcVB4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkP0TWM2OD1{LkS1O\|c6KM7:TR?=	Mn\TV2FPT0WU
NCI-H1395	M3PCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fOZmlEPTB;Mj60O\|EzOSEQvF2=	MYrTRW5ITVJ?
H4	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;Q[mlEPTB;Mj60PFM6OyEQvF2=	M4fOZ3NCVkeHUh?=
HT-3	Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlLFTWM2OD1{LkWxNFI1KM7:TR?=	M2naSXNCVkeHUh?=
P12-ICHIKAWA	MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYi3XI5pUUN3ME2yMlUzPTV7IN88US=>	MXjTRW5ITVJ?
COLO-800	MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoG1TWM2OD1{LkW0NVY3KM7:TR?=	NFf6eJFUSU6JRWK=
DB	Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{PnVGlEPTB;Mj61OVAyOyEQvF2=	NEn6e5NUSU6JRWK=
LCLC-97TM1	M2[x[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2r4[GlEPTB;Mj62NFAzQCEQvF2=	MnfpV2FPT0WU
Ca9-22	NXrveHJtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrPSlFKSzVyPUKuOlU6OzNizszN	NEDNVlRUSU6JRWK=
Becker	NEf2VGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXrkdXBMUUN3ME2yMlY3ODd6IN88US=>	M3i4eXNCVkeHUh?=
ACN	NHfm[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7DTWM2OD1{Lk[2O\|kh\|ryP	MVrTRW5ITVJ?
SJSA-1	MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVWxeGhrUUN3ME2yMlY3QDdizszN	M2HOOnNCVkeHUh?=
NCI-H1048	M17sTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHrQb5ZKSzVyPUKuOlg{OjFizszN	M4HzZ3NCVkeHUh?=
HEL	NUDab40yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPTTWM2OD1{LkewNlU1KM7:TR?=	NH;2dm5USU6JRWK=
NCI-H69	MmLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MU\JR\|UxRTJwN{G2NFEh\|ryP	NHe1Z49USU6JRWK=
639-V	M3LI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorMTWM2OD1{LkexO\|A{KM7:TR?=	Mn3UV2FPT0WU
U251	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYjJR\|UxRTJwN{OwN\|Ih\|ryP	NWTHUGZTW0GQR1XS
NCI-H1792	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1HTeGlEPTB;Mj63N\|c{QCEQvF2=	MmrDV2FPT0WU
EW-1	NXX2Z\|VkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn\4TWM2OD1{Lke1N\|I5KM7:TR?=	NVe5fIZGW0GQR1XS
ME-180	NXfrXWpKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3PMSGlEPTB;Mj63O\|c{PiEQvF2=	MYLTRW5ITVJ?
HH	NHXzS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVHJR\|UxRTJwOECwNFEh\|ryP	M1TmfXNCVkeHUh?=
SW954	M{j4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3SycmlEPTB;Mj64OVg{KM7:TR?=	NUHMVGlJW0GQR1XS
SF268	NYDsdIZRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3lXmc2UUN3ME2yMlg4OjJ3IN88US=>	NHHEXJVUSU6JRWK=
D-566MG	NGiwSZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjNV21KSzVyPUKuPVEzQTVizszN	MoLzV2FPT0WU
EM-2	NYLmcHBwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTJwOUKxPVMh\|ryP	NELVWmFUSU6JRWK=
NCI-H1299	NGrZdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3HaNWlEPTB;Mj65N\|c{PiEQvF2=	MXXTRW5ITVJ?
PSN1	M{nMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{W0bWlEPTB;Mz6wOVc5PiEQvF2=	NF7FOI9USU6JRWK=
JVM-3	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjsTWM2OD1\|LkC2O\|U3KM7:TR?=	NXW4WWx5W0GQR1XS
D-502MG	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYjIV4lzUUN3ME2zMlA4ODF7IN88US=>	NXz1Z5pXW0GQR1XS
SCC-4	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4fmTWlEPTB;Mz6wPVI4PiEQvF2=	NVHidpRuW0GQR1XS
GMS-10	NF7xVlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWO4SYY6UUN3ME2zMlA6Ozh6IN88US=>	M4rGS3NCVkeHUh?=
A427	NHG5SG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HvdGlEPTB;Mz6xNFg4OyEQvF2=	MV3TRW5ITVJ?
NH-12	NFexN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTNwMUG0OVYh\|ryP	NIf6RmhUSU6JRWK=
KM12	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLhO3g4UUN3ME2zMlEzOjd\|IN88US=>	NVnkSI5GW0GQR1XS
GI-1	M33hfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV3JR\|UxRTNwMUWyOVUh\|ryP	NGLUU2pUSU6JRWK=
TE-8	MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NG\KNWNKSzVyPUOuNVkzOzFizszN	MnTkV2FPT0WU
MKN1	MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHyTWM2OD1\|LkKwPFc2KM7:TR?=	NHvFN5lUSU6JRWK=
NCI-H810	Mn3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnjFTWM2OD1\|LkKyNVU2KM7:TR?=	MYnTRW5ITVJ?
GOTO	NEHQN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnrVTWM2OD1\|LkK4NFA1KM7:TR?=	NYHlbllGW0GQR1XS
T98G	Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUS0bZRrUUN3ME2zMlI5OjF4IN88US=>	NYTreHk4W0GQR1XS
HD-MY-Z	M{LobGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTNwM{[1OFIh\|ryP	NV3lNZNWW0GQR1XS
SNU-C2B	M4O0NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF3OS3JKSzVyPUOuN\|kxQTdizszN	NX;MWXZyW0GQR1XS
MOLT-4	NGrBSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{fxUmlEPTB;Mz6zPVA6QCEQvF2=	NV:4R\|I6W0GQR1XS
RPMI-7951	NWDuPXVTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mli1TWM2OD1\|LkO5O\|Mh\|ryP	M2[3TnNCVkeHUh?=
EW-11	MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2jJRmlEPTB;Mz60NVIzPCEQvF2=	NHLrTndUSU6JRWK=
RD	MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPVTWM2OD1\|LkSzNVMzKM7:TR?=	NVHjXIxFW0GQR1XS
SW48	NELUUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHu3V29KSzVyPUOuOFM{PThizszN	NUCxVI5UW0GQR1XS
BB65-RCC	MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2njRWlEPTB;Mz60OVM6PiEQvF2=	MVLTRW5ITVJ?
Ca-Ski	M1PVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mo\UTWM2OD1\|LkS3OVE1KM7:TR?=	Mn;FV2FPT0WU
CHP-134	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTETWM2OD1\|LkS4O\|U5KM7:TR?=	NIjwfJhUSU6JRWK=
CAL-33	NXzqO25xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEnNRnJKSzVyPUOuOVM{PjJizszN	NF[5e\|BUSU6JRWK=
TYK-nu	M2HPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUjuVYFoUUN3ME2zMlU{Pjd4IN88US=>	M1HEeXNCVkeHUh?=
LB831-BLC	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3n1b2lEPTB;Mz61OFAyPiEQvF2=	MoTlV2FPT0WU
KU-19-19	Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjoTWM2OD1\|Lk[wN\|A1KM7:TR?=	MnjjV2FPT0WU
KG-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTNwNkGxNFYh\|ryP	MkLRV2FPT0WU
COLO-829	M1HvU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4qz[WlEPTB;Mz62OlYyQCEQvF2=	MXvTRW5ITVJ?
HUTU-80	MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFfDWndKSzVyPUOuOlY3OjFizszN	Ml7LV2FPT0WU
NCI-H446	NETtXJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXnye25yUUN3ME2zMlY5OzRizszN	MXvTRW5ITVJ?
LB2241-RCC	M1zlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEHxPI1KSzVyPUOuOlg3OjVizszN	NWHmZYZQW0GQR1XS
JEG-3	NX6wRWlFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mny0TWM2OD1\|Lk[5NVkh\|ryP	Ml7zV2FPT0WU
LNCaP-Clone-FGC	M4\CO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnf1TWM2OD1\|LkewNFQyKM7:TR?=	NFn2So5USU6JRWK=
M059J	Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWPrPFB1UUN3ME2zMlcyPDZ6IN88US=>	Ml[1V2FPT0WU
SK-MES-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYTYU4ZDUUN3ME2zMlc{ODNizszN	Mlu5V2FPT0WU
GT3TKB	M3XBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Moq1TWM2OD1\|Lke1OlA1KM7:TR?=	NGjxNnVUSU6JRWK=
DOK	M4n3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1\oOWlEPTB;Mz63OlUzPiEQvF2=	M3r0e3NCVkeHUh?=
HO-1-N-1	NGjtSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXfJR\|UxRTNwN{m4NFEh\|ryP	M1T4OnNCVkeHUh?=
MZ1-PC	NVPBenZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7FRXVXUUN3ME2zMlgzQDh\|IN88US=>	M325TXNCVkeHUh?=
8305C	MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MojnTWM2OD1\|Lki4PVQ{KM7:TR?=	MnfOV2FPT0WU
CGTH-W-1	MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYfJR\|UxRTNwOUO1NFQh\|ryP	MkTqV2FPT0WU
LU-134-A	NF;qc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTNwOUW0NlIh\|ryP	MV\TRW5ITVJ?
C32	NYrGWGNIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\kXmlEPTB;Mz65OlU5OSEQvF2=	Mnz0V2FPT0WU
MOLT-13	Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTNwOU[4OVYh\|ryP	MX7TRW5ITVJ?
A375	MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFzPTIJKSzVyPUSuNFUyPjJizszN	NFPjO4hUSU6JRWK=
CAL-12T	NYLLbIdqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1q0R2lEPTB;ND6wOVc6PSEQvF2=	MXjTRW5ITVJ?
IGR-1	NFj0VZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTRwMUCyO\|Qh\|ryP	MUnTRW5ITVJ?
LB1047-RCC	MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTRwMUC0OFEh\|ryP	MWrTRW5ITVJ?
BHT-101	M1LVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1XMd2lEPTB;ND6xNFY5OyEQvF2=	NYrxO4tuW0GQR1XS
A431	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTRwMUSwPFEh\|ryP	NUfRXGVnW0GQR1XS
EPLC-272H	M1zaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWP4RXZSUUN3ME20MlE4PTl4IN88US=>	NFLFU4tUSU6JRWK=
HT-1376	NYD4SWd1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2nqWGlEPTB;ND6yN\|A2QSEQvF2=	MoCxV2FPT0WU
HCC1954	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFHkOoFKSzVyPUSuNlU4PDZizszN	MmfMV2FPT0WU
KYSE-510	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXf1WnhrUUN3ME20MlI3ODlizszN	NXLUemJmW0GQR1XS
PANC-03-27	MmH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmToTWM2OD12LkOwNFg{KM7:TR?=	MUXTRW5ITVJ?
MDA-MB-157	MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPhTWM2OD12LkOwOlU3KM7:TR?=	MV3TRW5ITVJ?
HOP-62	NVjNbmdYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVv6OFhrUUN3ME20MlMxQDV4IN88US=>	MUfTRW5ITVJ?
ETK-1	NUXWSmdWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV\OZ\|JWUUN3ME20MlM3OjB\|IN88US=>	NEnEe4ZUSU6JRWK=
MIA-PaCa-2	NFvFVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmjMTWM2OD12LkO2NlI4KM7:TR?=	NVHsOYZIW0GQR1XS
MHH-PREB-1	M2CzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3\rWWlEPTB;ND6zPVc4OyEQvF2=	NEjLZlhUSU6JRWK=
LXF-289	MnvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\DSmJKSzVyPUSuOFAzODJizszN	NYnvcmxtW0GQR1XS
ATN-1	NWi5bVJqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\PTWM2OD12LkSyN\|QyKM7:TR?=	M3;3R3NCVkeHUh?=
8505C	MnvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkPmTWM2OD12LkS1PFI2KM7:TR?=	NUfmOZFqW0GQR1XS
HOS	NGX6XoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfIUHpVUUN3ME20MlQ3PDV\|IN88US=>	M1ztWnNCVkeHUh?=
U-266	Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVTH[5Y6UUN3ME20MlYyODN{IN88US=>	NVrMe3FuW0GQR1XS
5637	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFHzUmxKSzVyPUSuOlE1PDRizszN	MVjTRW5ITVJ?
GCIY	NYHBUZVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofrTWM2OD12LkexNFE2KM7:TR?=	M3PKT3NCVkeHUh?=
MDA-MB-231	NF3hS\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NELvWmFKSzVyPUSuO\|IyOTVizszN	M4PMUHNCVkeHUh?=
RKO	MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkC1TWM2OD12LkeyPFE4KM7:TR?=	MkmxV2FPT0WU
COR-L23	Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXfwT5RsUUN3ME20Mlc1OjV4IN88US=>	MWLTRW5ITVJ?
DJM-1	Mon4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTRwN{m3Nlkh\|ryP	NVX2d4FnW0GQR1XS
D-423MG	Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NELEPI5KSzVyPUSuPFA5ODNizszN	NXjCb2M5W0GQR1XS
DMS-114	NWToNI5KT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\FO2ZKSzVyPUSuPFE{QDZizszN	M1S1SnNCVkeHUh?=
MHH-ES-1	NXy0Z5dGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXjJR\|UxRTRwOEK1NFQh\|ryP	NXnRcWc6W0GQR1XS
CAL-51	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrOSYlVUUN3ME20Mlg3QDR\|IN88US=>	NYf2fWhjW0GQR1XS
SW626	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYLJR\|UxRTRwOEm2PVch\|ryP	NFv4O2pUSU6JRWK=
COLO-824	MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITQR3NKSzVyPUSuPVA1ODhizszN	MnLZV2FPT0WU
NCI-H1437	M3jkUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYPUVHVUUUN3ME20MlkzQTNizszN	MnvwV2FPT0WU
CAL-39	M33xcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGnQUFdKSzVyPUSuPVM6QDhizszN	NUnCb4xXW0GQR1XS
PC-3	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEm2R\|dKSzVyPUSuPVQ3PDhizszN	M1nJPHNCVkeHUh?=
A101D	NYfpXIxVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHXDbJRKSzVyPUSuPVY5PjVizszN	NG\oR41USU6JRWK=
ES1	MlTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NE\MN4pKSzVyPUWuNFAyOyEQvF2=	MkH3V2FPT0WU
TE-1	M{LYbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFnJSmxKSzVyPUWuNFM3PjZizszN	NF7xe5JUSU6JRWK=
KP-N-YN	M4nQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{i5XmlEPTB;NT6wOVY4KM7:TR?=	M{XtWnNCVkeHUh?=
EFO-27	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTnTWM2OD13LkC2N\|I6KM7:TR?=	MY\TRW5ITVJ?
BT-549	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWLFU2lsUUN3ME21MlA4PzN4IN88US=>	Mlv5V2FPT0WU
HLE	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTVwMUG3N\|Qh\|ryP	NH;wb2hUSU6JRWK=
SW982	NECybIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nyWGlEPTB;NT6xN\|M4PCEQvF2=	NHe0Sm1USU6JRWK=
SCC-25	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX\aR\|U2UUN3ME21MlE6ODR4IN88US=>	NVO1coxQW0GQR1XS
SK-MEL-28	NFvsdWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFfQeWtKSzVyPUWuNlA{OTNizszN	MX3TRW5ITVJ?
CaR-1	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\qTWM2OD13LkKwO\|I3KM7:TR?=	M1iwTnNCVkeHUh?=
MLMA	M{Hkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkjDTWM2OD13LkKzOFM3KM7:TR?=	NVHpbIVTW0GQR1XS
VM-CUB-1	M3zlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2D4cWlEPTB;NT6yN\|Q{QSEQvF2=	NEHjWJhUSU6JRWK=
KNS-42	NUO2OVRkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFXUXIdKSzVyPUWuNlYyPiEQvF2=	Mme3V2FPT0WU
TK10	M2XsOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV;2SodvUUN3ME21MlM3ODh4IN88US=>	MUDTRW5ITVJ?
MEG-01	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnuxTWM2OD13LkO2Nlc1KM7:TR?=	MknDV2FPT0WU
DEL	MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NID4[WhKSzVyPUWuN\|kxOjNizszN	M3H3fHNCVkeHUh?=
SJRH30	M3j5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFz3b2ZKSzVyPUWuN\|kzOTNizszN	M4rvZ3NCVkeHUh?=
SK-PN-DW	NYj4NZMyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M33lUmlEPTB;NT60N\|U5QSEQvF2=	NELQPFBUSU6JRWK=
TE-10	M3uxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXvJR\|UxRTVwNES4PVMh\|ryP	MXHTRW5ITVJ?
KNS-81-FD	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3S0VWlEPTB;NT61NFA6OiEQvF2=	NEOyRYpUSU6JRWK=
BHY	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX:5Sot1UUN3ME21MlUyODdizszN	NYfaWG1tW0GQR1XS
KYSE-270	NFTwTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml3MTWM2OD13LkWzOVM3KM7:TR?=	M2rUUnNCVkeHUh?=
NCI-H650	NHL2N3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH7aVGhKSzVyPUWuOVcyOTRizszN	MoXnV2FPT0WU
L-363	Mmj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHnvdGhKSzVyPUWuOlk1PzZizszN	MWfTRW5ITVJ?
TCCSUP	NXvoc2pPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfuSplVUUN3ME21MlcyPzd6IN88US=>	MoqyV2FPT0WU
SCH	MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DjOWlEPTB;NT63OFc3PyEQvF2=	M{fUSnNCVkeHUh?=
HTC-C3	MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTVwN{e2OFQh\|ryP	M2HIVnNCVkeHUh?=
J-RT3-T3-5	NYmx[5lGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUTOVJFMUUN3ME21MlgxPzl2IN88US=>	M2fwOHNCVkeHUh?=
Hs-578-T	M3\3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV7JR\|UxRTVwOEO2NFch\|ryP	Mo\nV2FPT0WU
M14	NHTzXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTVwOE[3NlYh\|ryP	NHP0blhUSU6JRWK=
HT-144	Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFH6XnhKSzVyPUWuPFY5OzJizszN	MX7TRW5ITVJ?
CAL-54	MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{Tpe2lEPTB;NT65N\|MyPCEQvF2=	MnH0V2FPT0WU
T47D	NH\NVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIHJWXFKSzVyPUWuPVYyOiEQvF2=	NWHobItWW0GQR1XS
GB-1	M1ftZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTxNo1wUUN3ME22MlAzODZ6IN88US=>	M3\veHNCVkeHUh?=
HSC-2	MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXLMUVdUUUN3ME22MlEzOzV\|IN88US=>	MWPTRW5ITVJ?
SiHa	M{OyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFvPdY9KSzVyPU[uNVQxQTdizszN	MVLTRW5ITVJ?
OMC-1	NFPrcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnfCTWM2OD14LkO1OFQyKM7:TR?=	M1XEO3NCVkeHUh?=
HGC-27	NUXNblZwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWTYSld5UUN3ME22MlM2Pzh4IN88US=>	MmLnV2FPT0WU
FTC-133	M4Xv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NELibGhKSzVyPU[uOFY2PTFizszN	NYHEcmpwW0GQR1XS
KS-1	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXaTWM2OD14LkWyNVQ4KM7:TR?=	M4jFTHNCVkeHUh?=
HT-1080	NYHCV4I5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4jSOGlEPTB;Nj61OFA1OiEQvF2=	MnWxV2FPT0WU
SKG-IIIa	NH3FSmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlLwTWM2OD14LkW2NlY{KM7:TR?=	M3rP[3NCVkeHUh?=
OCUB-M	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnvKTWM2OD14Lk[wO\|ch\|ryP	NEG1RmRUSU6JRWK=
MDA-MB-175-VII	NYLZcYJJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{XhUmlEPTB;Nj62NlA6KM7:TR?=	MlTMV2FPT0WU
BB30-HNC	M3rzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGTWe2RKSzVyPU[uOlc1PDRizszN	MWXTRW5ITVJ?
D-542MG	NXTudI1VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFT0Uo5KSzVyPU[uO\|MxQSEQvF2=	MYXTRW5ITVJ?
NCI-H2405	M3qxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M33NZWlEPTB;Nj63OFg2PSEQvF2=	NHLLSFZUSU6JRWK=
SW1573	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTZwN{izNVkh\|ryP	NYTJdoVvW0GQR1XS
NCI-SNU-1	MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1fIW2lEPTB;Nj63PVAzOiEQvF2=	NVrNOINrW0GQR1XS
RT-112	NEX3SYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2HsO2lEPTB;Nj63PVQ3OyEQvF2=	M3zJT3NCVkeHUh?=
COR-L88	NGXXUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvkS2VWUUN3ME22Mlc6PzlzIN88US=>	NG\JeXhUSU6JRWK=
SCC-9	MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4\wOmlEPTB;Nj64NlU2KM7:TR?=	NVGzeJJwW0GQR1XS
U-87-MG	MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MormTWM2OD14LkizPFI3KM7:TR?=	MmDvV2FPT0WU
Detroit562	MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1L3Z2lEPTB;Nj64OVk6OSEQvF2=	NIe2fZhUSU6JRWK=
LC-2-ad	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmTXTWM2OD14Lki2NlkzKM7:TR?=	NW\rSW5SW0GQR1XS
IGROV-1	NWP6SFFwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTZwOUK1PFMh\|ryP	M1TOfnNCVkeHUh?=
OVCAR-8	M2jRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlK3TWM2OD14Lkm0NlI6KM7:TR?=	M2XQSHNCVkeHUh?=
SNU-387	M4rxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrMd41VUUN3ME22Mlk6PTF4IN88US=>	Mle5V2FPT0WU
TGBC1TKB	NEPCTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTdwMUWyO\|ch\|ryP	MXzTRW5ITVJ?
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HEC-1	NXLPXJcyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTdwMkWzPFch\|ryP	NISxUlJUSU6JRWK=
GI-ME-N	MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXrJR\|UxRTdwMkmxOVgh\|ryP	MnrxV2FPT0WU
KYSE-520	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYDJR\|UxRTdwMkmyPUDPxE1?	NY\vfmZYW0GQR1XS
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CAL-27	NWHsV5hST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjkTWM2OD16LkGyO\|Ih\|ryP	Mlm2V2FPT0WU
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NCI-H2087	MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnvKTWM2OD16LkO2NVU5KM7:TR?=	Mn;SV2FPT0WU
NCI-H2122	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkWwTWM2OD16LkSwOFc6KM7:TR?=	MljVV2FPT0WU
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DMS-273	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlX4TWM2OD16Lki5OlI{KM7:TR?=	MnOwV2FPT0WU
MPP-89	MnfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXnMfWJ2UUN3ME24MlkyOzRzIN88US=>	M33iRnNCVkeHUh?=
EW-22	NV7WWYxTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3uSYp[UUN3ME24MlkyOzh{IN88US=>	Mm\FV2FPT0WU
RCM-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{jYRWlEPTB;OD65OlQ5PiEQvF2=	MmHhV2FPT0WU
BT-474	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlizTWM2OD16Lkm4PFczKM7:TR?=	MlvCV2FPT0WU
TI-73	NEDLOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWPJR\|UxRTlwMEO0PVYh\|ryP	NIXKZVRUSU6JRWK=
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NB17	M37oUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2DkbmlEPTB;OT6xOFU{PSEQvF2=	NXy1c5FYW0GQR1XS
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HuCCT1	NHz2emJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;uTpNCUUN3ME25MlQ4PDB4IN88US=>	MmjCV2FPT0WU
A704	NIDhTJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEHIfm5KSzVyPUmuOFc4PDVizszN	MmjOV2FPT0WU
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KINGS-1	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUHLUlB3UUN3ME25MlY6OzdizszN	MYnTRW5ITVJ?
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KYSE-410	M3TMRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{fMSGlEPTB;MUCuNFYyPSEQvF2=	M1v2O3NCVkeHUh?=
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NB5	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fRemlEPTB;MUCuOVQxPSEQvF2=	NGrHRmZUSU6JRWK=
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SF539	NGHO[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPZTWM2OD1zMD63NVg5KM7:TR?=	NGKycoNUSU6JRWK=
CAL-120	M{LMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XXcmlEPTB;MUCuO\|U6PyEQvF2=	NYTaOFN{W0GQR1XS
GR-ST	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1W4RmlEPTB;MUGuNlk5KM7:TR?=	MmqyV2FPT0WU
IA-LM	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mmm2TWM2OD1zMT6zOFg3KM7:TR?=	MY\TRW5ITVJ?
NCI-H2452	M3zQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX76W\|F[UUN3ME2xNU4{QTJ5IN88US=>	MW\TRW5ITVJ?
NCI-H1648	MnnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIrnUIxKSzVyPUGxMlQ3OjlizszN	NUfoOo9LW0GQR1XS
YH-13	MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M33id2lEPTB;MUGuOFc1OiEQvF2=	Ml7pV2FPT0WU
NCI-H2228	NFvRNodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX64WGh{UUN3ME2xNU41QTJ6IN88US=>	MXHTRW5ITVJ?
LN-405	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUHJR\|UxRTFzLkW5Nlch\|ryP	M{TOfHNCVkeHUh?=
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HPAF-II	MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3UPYdOUUN3ME2xNU45OzV4IN88US=>	NWHS[GRSW0GQR1XS
BB49-HNC	NH3ybVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M370N2lEPTB;MUGuPFM4PSEQvF2=	MoL3V2FPT0WU
KGN	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLKTWM2OD1zMT64OVg6KM7:TR?=	M4\rTHNCVkeHUh?=
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SK-HEP-1	M3PjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTF{LkK2NVMh\|ryP	MmHDV2FPT0WU
HCE-4	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mln5TWM2OD1zMj6yOlk6KM7:TR?=	NYHzU2ViW0GQR1XS
NCI-H1581	M3;FZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MknzTWM2OD1zMj6yPFE6KM7:TR?=	MnnvV2FPT0WU
NCI-H23	MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWXJR\|UxRTF{LkOxNlUh\|ryP	MUHTRW5ITVJ?
NCI-H596	MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIXNPY5KSzVyPUGyMlQ4QThizszN	NYjqfmdIW0GQR1XS
NB69	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVTJR\|UxRTF{Lke1PFUh\|ryP	MXnTRW5ITVJ?
ChaGo-K-1	M3HWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XGeGlEPTB;MUKuO\|Y1QSEQvF2=	M2nGcnNCVkeHUh?=
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KALS-1	NXS3NI9DT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4XnTmlEPTB;MUOuNFk2KM7:TR?=	MnnLV2FPT0WU
MDA-MB-415	NEHvZWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37uSWlEPTB;MUOuNVYxQSEQvF2=	NXLibYR3W0GQR1XS
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NCI-H2052	NUTLW4VmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4nyW2lEPTB;MUOuN\|g1QCEQvF2=	M{LpNXNCVkeHUh?=
HOP-92	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFuzNGhKSzVyPUGzMlc6QTdizszN	M2e1WHNCVkeHUh?=
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A253	Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\BfGlEPTB;MUSuNlI2KM7:TR?=	M3O1VXNCVkeHUh?=
NCI-H1155	MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTF2LkK3OFch\|ryP	MXrTRW5ITVJ?
SNB75	NHvBZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHZTWM2OD1zND6zPFk{KM7:TR?=	M2P5Z3NCVkeHUh?=
23132-87	NIXQOHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlX5TWM2OD1zND64N\|U{KM7:TR?=	M{fuZXNCVkeHUh?=
Calu-3	NGnTfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVHJR\|UxRTF2Lki3OFMh\|ryP	MXfTRW5ITVJ?
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SF126	MnzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Moe1TWM2OD1zNT63Nlg2KM7:TR?=	MWrTRW5ITVJ?
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NCI-H526	NWTvb2k2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXvJR\|UxRTN5LkK3O\|Ih\|ryP	MV\TRW5ITVJ?
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SHP-77	NYDPRnhbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkH4TWM2OD12Mz6xPFI5KM7:TR?=	Mln4V2FPT0WU
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DBTRG-05MG	MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M13FbmlEPTB;NESuOlk6PiEQvF2=	M1HsRnNCVkeHUh?=
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KYSE-70	NHrEU3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1LPT2lEPTB;NEeuO\|IzOiEQvF2=	MVHTRW5ITVJ?
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NCI-H1838	MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTR6LkO0OVgh\|ryP	Mo\2V2FPT0WU
NCI-H1573	NH:wb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWKzU2k1UUN3ME20PE43Pzh3IN88US=>	NHTxW4JUSU6JRWK=
HCC1395	NX\OWHNtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTR6Lkm5NkDPxE1?	NHvFT5pUSU6JRWK=
NCI-H2291	NYT6VGVST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmHaTWM2OD12OT61PVg5KM7:TR?=	NVi2O4V3W0GQR1XS
RH-18	NYX5UFJoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXnQNnlNUUN3ME21NE4xQDh2IN88US=>	NXz4cWRFW0GQR1XS

... Click to View More Cell Line Experimental Data

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
PF-4708671

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with K_i/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
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CHIR-99021 (CT99021) HCl

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.
LY294002

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3-Methyladenine (3-MA)

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BI-D1870

Cited by 7 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

Choose Your Country or Region

By Signaling Pathways

By product type

BI-D1870

Cited by 7 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)