BI-D1870

For research use only. Not for use in humans.

Catalog No.S2843

15 publications

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Size Price Stock Quantity  
USD 170 In stock
USD 270 In stock
USD 670 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's BI-D1870 has been cited by 15 publications

4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

  • (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

  • Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NGDrfllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[4W|FKSzVyPUCuNFM2QCEQvF2= MmW4V2FPT0WU
H9 MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoriTWM2OD1yLkC2NFE6KM7:TR?= NXSybYt3W0GQR1XS
KARPAS-45 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HCc2lEPTB;MD6xOlUzPSEQvF2= MoCyV2FPT0WU
NCI-H720 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMUexPVQh|ryP M3uwcHNCVkeHUh?=
CTV-1 M{TCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j4eGlEPTB;MD60O|g4OiEQvF2= NIfxRolUSU6JRWK=
DU-4475 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwNUC0NVch|ryP MUnTRW5ITVJ?
A172 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fQXWlEPTB;MD61NVcxPSEQvF2= M2PIWXNCVkeHUh?=
EW-18 MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHIUGFzUUN3ME2wMlYzOjFzIN88US=> NX3FT5NsW0GQR1XS
KU812 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrIfpVKSzVyPUCuOlI3OjNizszN NWO1U4FxW0GQR1XS
KP-N-YS MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNkiyNlMh|ryP M1X4dHNCVkeHUh?=
SBC-1 NYLsVWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{S4e2lEPTB;MD62PVUzPCEQvF2= NEj0d5NUSU6JRWK=
ECC10 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGyT4lKSzVyPUCuO|AxQTRizszN MkfZV2FPT0WU
GAMG NF[5d|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnG0TWM2OD1yLke0O|E4KM7:TR?= M1vyc3NCVkeHUh?=
NCI-H209 NGm5SIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDhfZpKSzVyPUCuO|Y5OiEQvF2= MnrMV2FPT0WU
MC-IXC MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHJTVVCUUN3ME2wMlc6PTh7IN88US=> NFz2XlJUSU6JRWK=
HSC-3 NIjTeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTnTWM2OD1yLkixO|Y6KM7:TR?= NHjQbYtUSU6JRWK=
IST-SL1 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL2Z5lKSzVyPUCuPFQ2PzRizszN NIDVNo5USU6JRWK=
LU-139 M{LQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwOES5OVgh|ryP M3HQN3NCVkeHUh?=
ML-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;zToNKSzVyPUCuPFU2PzVizszN MnWzV2FPT0WU
CAL-62 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLhdHljUUN3ME2wMlg5OTV{IN88US=> M1TqPXNCVkeHUh?=
HL-60 NHjF[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\3RmlEPTB;MD64PFM3OiEQvF2= Mn;WV2FPT0WU
KY821 NFzFenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwOEi4NVIh|ryP NInacnVUSU6JRWK=
ES7 NWr6O|RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYWzWW9CUUN3ME2wMlkyPjB5IN88US=> MYrTRW5ITVJ?
MV-4-11 M2HQdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwOUe4PVch|ryP NVTGcFlJW0GQR1XS
Daoy MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nadmlEPTB;MD65PFc3PyEQvF2= M4LLW3NCVkeHUh?=
EoL-1-cell NIWwZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\4SHM2UUN3ME2xMlAyQDd6IN88US=> NIDlcIRUSU6JRWK=
TGW NELIfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fNUWlEPTB;MT6wOVEzPCEQvF2= MlnYV2FPT0WU
LAMA-84 M4HNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXaTWM2OD1zLkGyO|k1KM7:TR?= NYHDfJl[W0GQR1XS
KOSC-2 M4C4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHDc45KSzVyPUGuNVM{QDVizszN M4PBVnNCVkeHUh?=
A549 NVK4UYZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDCdnVHUUN3ME2xMlMxQTV3IN88US=> NXrn[FRNW0GQR1XS
CTB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;GTWM2OD1zLkS0Olc6KM7:TR?= MXLTRW5ITVJ?
NCI-H292 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwNE[wOlkh|ryP M{OwdHNCVkeHUh?=
LoVo MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1iwW2lEPTB;MT60Olc2PSEQvF2= M3jqR3NCVkeHUh?=
BFTC-905 NWTCVGRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPVdY1UUUN3ME2xMlU3OzN{IN88US=> NH\VcGJUSU6JRWK=
BE-13 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFwNUi3NFkh|ryP MlPzV2FPT0WU
KE-37 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFwNUm0O|gh|ryP NFLJOYhUSU6JRWK=
HN Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLHOlBKSzVyPUGuOlE{PjhizszN M13rS3NCVkeHUh?=
A3-KAW NF;qPZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTCTWM2OD1zLk[yPFM1KM7:TR?= NFXpeZBUSU6JRWK=
NEC8 M1jjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFwN{CxNVUh|ryP M1r2dXNCVkeHUh?=
Ramos-2G6-4C10 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq4bHByUUN3ME2xMlcxPDR2IN88US=> MYPTRW5ITVJ?
NB10 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXu4ZopqUUN3ME2xMlc4PjNizszN NYL4XHNlW0GQR1XS
NBsusSR MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULP[3NHUUN3ME2xMlgzQTZzIN88US=> MYjTRW5ITVJ?
ES4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:we2lEPTB;MT64OVE1OyEQvF2= MknYV2FPT0WU
ES8 NFrPS41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDTWmhKSzVyPUGuPFc4OjRizszN MoTDV2FPT0WU
CHL-1 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwOUW3PVIh|ryP M2PLW3NCVkeHUh?=
NCI-H2029 NYPVOIM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC3dJFKSzVyPUGuPVczPDFizszN M3jWbXNCVkeHUh?=
YKG-1 NVHoNZEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTFwOUi0N|Ih|ryP NWnVb5FtW0GQR1XS
BV-173 NVHXbpRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTFwOUi2OlYh|ryP NHvTO2xUSU6JRWK=
697 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwMEKyNlgh|ryP NUTnfWtVW0GQR1XS
SK-NEP-1 M{nufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofpTWM2OD1{LkC0OEDPxE1? MkX1V2FPT0WU
LOXIMVI NFHSb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfKTWM2OD1{LkC0OFM1KM7:TR?= Mn7FV2FPT0WU
QIMR-WIL NY\Xe|NNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwMEe4OFkh|ryP M1jXVHNCVkeHUh?=
DU-145 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXQeXRKSzVyPUKuNVExPTZizszN NXmyT3BDW0GQR1XS
NB14 M4\wb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP4SFdGUUN3ME2yMlEyOzJzIN88US=> NG\BfoxUSU6JRWK=
G-361 M3\qZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG0dFBPUUN3ME2yMlEzOjFizszN M3nqVHNCVkeHUh?=
BPH-1 NHHTOpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHZPHVKSzVyPUKuNVI6PTdizszN M1K2VXNCVkeHUh?=
KYSE-150 NW\kSmlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTJwMUWyN|Qh|ryP MUTTRW5ITVJ?
HMV-II NEjD[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;DV2lEPTB;Mj6xOlY{OyEQvF2= M4nSZ3NCVkeHUh?=
TE-9 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzaTWM2OD1{LkG3N|c3KM7:TR?= M1XYbHNCVkeHUh?=
8-MG-BA NX3rTXRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnvWW5lUUN3ME2yMlI{PDZzIN88US=> MXrTRW5ITVJ?
ES5 NGi0PYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[wc4tKSzVyPUKuNlM3OzNizszN MmX0V2FPT0WU
D-283MED M4PQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq4O5R[UUN3ME2yMlI{Pjl3IN88US=> NUHrXWhYW0GQR1XS
SK-N-AS NHPKc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT2TWM2OD1{LkK5NFU6KM7:TR?= NUO2VGdnW0GQR1XS
SW1710 NHHye3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjmSnJjUUN3ME2yMlMxPjZzIN88US=> M1fabHNCVkeHUh?=
GCT NH23bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOxTWM2OD1{LkOxN|U5KM7:TR?= NFzMNphUSU6JRWK=
AGS NXvxO5hYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnX1TWM2OD1{LkO0OFA1KM7:TR?= MorXV2FPT0WU
HuO9 NI\qZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33pWWlEPTB;Mj6zOlgzPCEQvF2= NEjYRlZUSU6JRWK=
MN-60 M4HEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJwNES4PFMh|ryP MX7TRW5ITVJ?
NB6 NH;TO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqyTWM2OD1{LkS1O|c6KM7:TR?= M2XlTHNCVkeHUh?=
NCI-H1395 M1yyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH65bFNKSzVyPUKuOFcyOjFizszN NYryXot[W0GQR1XS
H4 M13RbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fiPGlEPTB;Mj60PFM6OyEQvF2= MXfTRW5ITVJ?
HT-3 M3Lxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17Qc2lEPTB;Mj61NVAzPCEQvF2= NHPPd21USU6JRWK=
P12-ICHIKAWA NGnSeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDyT4tIUUN3ME2yMlUzPTV7IN88US=> M3HHW3NCVkeHUh?=
COLO-800 MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\UTWM2OD1{LkW0NVY3KM7:TR?= M3zrT3NCVkeHUh?=
DB NIDZcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\CTWM2OD1{LkW1NFE{KM7:TR?= NHmyfZhUSU6JRWK=
LCLC-97TM1 NGD3cJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwNkCwNlgh|ryP MUnTRW5ITVJ?
Ca9-22 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJwNkW5N|Mh|ryP MVLTRW5ITVJ?
Becker Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3K[4NKSzVyPUKuOlYxPzhizszN M2rYVHNCVkeHUh?=
ACN NYDETmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL3TWM2OD1{Lk[2O|kh|ryP MYDTRW5ITVJ?
SJSA-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[1TWM2OD1{Lk[2PFch|ryP MXXTRW5ITVJ?
NCI-H1048 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDwNYtKSzVyPUKuOlg{OjFizszN MXfTRW5ITVJ?
HEL NU\SNI9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj6TWM2OD1{LkewNlU1KM7:TR?= MmXsV2FPT0WU
NCI-H69 M3TjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJwN{G2NFEh|ryP MnHDV2FPT0WU
639-V NUn3S2pNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHjTWM2OD1{LkexO|A{KM7:TR?= Mle5V2FPT0WU
U251 NX7VdW1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzZTWM2OD1{LkezNFMzKM7:TR?= NESxV4JUSU6JRWK=
NCI-H1792 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrzd|ZvUUN3ME2yMlc{PzN6IN88US=> M{LhXnNCVkeHUh?=
EW-1 NVXyToR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q2[GlEPTB;Mj63OVMzQCEQvF2= M2fhPXNCVkeHUh?=
ME-180 NV;abnhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwN{e3N|Yh|ryP NUmzRlhOW0GQR1XS
HH MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfXbZNMUUN3ME2yMlgxODBzIN88US=> M{Dxb3NCVkeHUh?=
SW954 NG\RZ3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jGcGlEPTB;Mj64OVg{KM7:TR?= MVTTRW5ITVJ?
SF268 NE\tW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLyUYtKSzVyPUKuPFczOjVizszN MWrTRW5ITVJ?
D-566MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jl[GlEPTB;Mj65NVI6PSEQvF2= NHy4XmtUSU6JRWK=
EM-2 M3LzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPqOW06UUN3ME2yMlkzOTl|IN88US=> M1\xcnNCVkeHUh?=
NCI-H1299 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLOTWM2OD1{LkmzO|M3KM7:TR?= NYDC[lRZW0GQR1XS
PSN1 NGTrO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUiydXBXUUN3ME2zMlA2Pzh4IN88US=> NFzXOolUSU6JRWK=
JVM-3 NW\XfG04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HMZ2lEPTB;Mz6wOlc2PiEQvF2= MVvTRW5ITVJ?
D-502MG M1jQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDj[4hPUUN3ME2zMlA4ODF7IN88US=> MUDTRW5ITVJ?
SCC-4 NXPWd3ptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXvS|N7UUN3ME2zMlA6Ojd4IN88US=> MV\TRW5ITVJ?
GMS-10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTNwMEmzPFgh|ryP MlvRV2FPT0WU
A427 M4PyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwMUC4O|Mh|ryP NV\JTXRjW0GQR1XS
NH-12 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwMUG0OVYh|ryP NV7hfmo6W0GQR1XS
KM12 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrkTWM2OD1|LkGyNlc{KM7:TR?= NFn5co5USU6JRWK=
GI-1 M{PGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETZemxKSzVyPUOuNVUzPTVizszN M13CWXNCVkeHUh?=
TE-8 M{XsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWxVWgzUUN3ME2zMlE6OjNzIN88US=> M3;oTnNCVkeHUh?=
MKN1 NYHt[3l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:ybXFKSzVyPUOuNlA5PzVizszN MWDTRW5ITVJ?
NCI-H810 NEXleoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DSOGlEPTB;Mz6yNlE2PSEQvF2= NVXZe4NFW0GQR1XS
GOTO NX3NV2RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW3TWM2OD1|LkK4NFA1KM7:TR?= MUjTRW5ITVJ?
T98G M3u0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfJZphtUUN3ME2zMlI5OjF4IN88US=> NHXNXGdUSU6JRWK=
HD-MY-Z NULxV5Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD6TWM2OD1|LkO2OVQzKM7:TR?= MXzTRW5ITVJ?
SNU-C2B NXv0V3BXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPVTWM2OD1|LkO5NFk4KM7:TR?= MlL2V2FPT0WU
MOLT-4 NIjYSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XnPGlEPTB;Mz6zPVA6QCEQvF2= MlfHV2FPT0WU
RPMI-7951 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUm3fYFpUUN3ME2zMlM6PzNizszN M3zvbnNCVkeHUh?=
EW-11 NXm1S5BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLHUopKSzVyPUOuOFEzOjRizszN NWPJZWxwW0GQR1XS
RD NU\hfm9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTNwNEOxN|Ih|ryP MmLDV2FPT0WU
SW48 M2Dabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\4VmlEPTB;Mz60N|M2QCEQvF2= NWXFZm45W0GQR1XS
BB65-RCC MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHocm9LUUN3ME2zMlQ2Ozl4IN88US=> MlzzV2FPT0WU
Ca-Ski NIC0colIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r1bmlEPTB;Mz60O|UyPCEQvF2= NIXZdYZUSU6JRWK=
CHP-134 NXnLNnZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTNwNEi3OVgh|ryP MWnTRW5ITVJ?
CAL-33 M4nUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTNwNUOzOlIh|ryP M4DHRXNCVkeHUh?=
TYK-nu NYKxNmtmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7hS|FKSzVyPUOuOVM3PzZizszN NID1UI9USU6JRWK=
LB831-BLC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP1TWM2OD1|LkW0NFE3KM7:TR?= NHLNd5lUSU6JRWK=
KU-19-19 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{WwdGlEPTB;Mz62NFMxPCEQvF2= MlPnV2FPT0WU
KG-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HwW2lEPTB;Mz62NVExPiEQvF2= M1y0RXNCVkeHUh?=
COLO-829 NX;GcXJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DkbGlEPTB;Mz62OlYyQCEQvF2= NHnyV5ZUSU6JRWK=
HUTU-80 M4SxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTNwNk[2NlEh|ryP NVTwOnlqW0GQR1XS
NCI-H446 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTNwNkizOEDPxE1? NHjGVpFUSU6JRWK=
LB2241-RCC M3Xp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL6TWM2OD1|Lk[4OlI2KM7:TR?= NYfuWpRnW0GQR1XS
JEG-3 NVz4OGRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vhWmlEPTB;Mz62PVE6KM7:TR?= NV3WOoxHW0GQR1XS
LNCaP-Clone-FGC M3\4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTNwN{CwOFEh|ryP NYDWUHdXW0GQR1XS
M059J MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom2TWM2OD1|LkexOFY5KM7:TR?= NXzHZYRCW0GQR1XS
SK-MES-1 Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjwTWM2OD1|LkezNFMh|ryP NWPxd|A3W0GQR1XS
GT3TKB NGrqcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zRZmlEPTB;Mz63OVYxPCEQvF2= NW\iOZZCW0GQR1XS
DOK NVXXWGRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwN{[1NlYh|ryP MX3TRW5ITVJ?
HO-1-N-1 NVPz[HI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXV[41KSzVyPUOuO|k5ODFizszN NI\5VpFUSU6JRWK=
MZ1-PC M3S1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTNwOEK4PFMh|ryP MYLTRW5ITVJ?
8305C MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P2U2lEPTB;Mz64PFk1OyEQvF2= MXPTRW5ITVJ?
CGTH-W-1 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTNwOUO1NFQh|ryP MVjTRW5ITVJ?
LU-134-A NFzZOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3pbFQ1UUN3ME2zMlk2PDJ{IN88US=> Mln6V2FPT0WU
C32 NF\yPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPMcJgzUUN3ME2zMlk3PThzIN88US=> M4rkeHNCVkeHUh?=
MOLT-13 NUX2XYl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTNwOU[4OVYh|ryP M1P5WXNCVkeHUh?=
A375 Ml\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTRwMEWxOlIh|ryP NHfmN4tUSU6JRWK=
CAL-12T NUPsc21sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H0dGlEPTB;ND6wOVc6PSEQvF2= NXvXO205W0GQR1XS
IGR-1 NUPoVJE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTlTWM2OD12LkGwNlc1KM7:TR?= NWm2eFd2W0GQR1XS
LB1047-RCC MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;xWpJZUUN3ME20MlExPDRzIN88US=> M2TXVnNCVkeHUh?=
BHT-101 M1;5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfEe2NKSzVyPUSuNVA3QDNizszN MX\TRW5ITVJ?
A431 MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn1WI1KSzVyPUSuNVQxQDFizszN M4TLVXNCVkeHUh?=
EPLC-272H NHvVOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3YdpFRUUN3ME20MlE4PTl4IN88US=> NInUd5hUSU6JRWK=
HT-1376 NWnQNJFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1niT2lEPTB;ND6yN|A2QSEQvF2= NV;4cHhWW0GQR1XS
HCC1954 NH;JWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwMkW3OFYh|ryP NEC5PIFUSU6JRWK=
KYSE-510 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfWXYFKSzVyPUSuNlYxQSEQvF2= NHfKdGhUSU6JRWK=
PANC-03-27 M2rjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofWTWM2OD12LkOwNFg{KM7:TR?= NFPOZYtUSU6JRWK=
MDA-MB-157 NHm1cmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LqPWlEPTB;ND6zNFY2PiEQvF2= NYXSdVhxW0GQR1XS
HOP-62 NEnHUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfONWgyUUN3ME20MlMxQDV4IN88US=> MmnxV2FPT0WU
ETK-1 NXvEOo4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rtU2lEPTB;ND6zOlIxOyEQvF2= NVXLfIdqW0GQR1XS
MIA-PaCa-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;wTWM2OD12LkO2NlI4KM7:TR?= NXr1[WNSW0GQR1XS
MHH-PREB-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTRwM{m3O|Mh|ryP MlXDV2FPT0WU
LXF-289 NYSzOlJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3MU3NKSzVyPUSuOFAzODJizszN NXG2XIk{W0GQR1XS
ATN-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4SxemlEPTB;ND60NlM1OSEQvF2= M2XUNnNCVkeHUh?=
8505C NHq0b5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHBV3lKSzVyPUSuOFU5OjVizszN NWTEdXF{W0GQR1XS
HOS MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfsTWM2OD12LkS2OFU{KM7:TR?= MnHRV2FPT0WU
U-266 NWD0fnc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGS4[5pKSzVyPUSuOlExOzJizszN MknxV2FPT0WU
5637 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnYSFlzUUN3ME20MlYyPDR2IN88US=> MWnTRW5ITVJ?
GCIY MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLFXVR2UUN3ME20MlcyODF3IN88US=> MYDTRW5ITVJ?
MDA-MB-231 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTRwN{KxNVUh|ryP NU\tNmhxW0GQR1XS
RKO NUHFZoNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDFPIpFUUN3ME20MlczQDF5IN88US=> NFj5RndUSU6JRWK=
COR-L23 M{DIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrORYkzUUN3ME20Mlc1OjV4IN88US=> MUnTRW5ITVJ?
DJM-1 NIfvcHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonOTWM2OD12Lke5O|I6KM7:TR?= MlzYV2FPT0WU
D-423MG MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTRwOEC4NFMh|ryP NFPwfXRUSU6JRWK=
DMS-114 NGD1b2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\u[WlEPTB;ND64NVM5PiEQvF2= M17DVnNCVkeHUh?=
MHH-ES-1 NFTydFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX6TWM2OD12LkiyOVA1KM7:TR?= MWTTRW5ITVJ?
CAL-51 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTpeoVOUUN3ME20Mlg3QDR|IN88US=> NGjIXmNUSU6JRWK=
SW626 NEHXSI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRwOEm2PVch|ryP MVXTRW5ITVJ?
COLO-824 NXXSWHE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDmTJJUUUN3ME20MlkxPDB6IN88US=> Ml;XV2FPT0WU
NCI-H1437 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXBPG9bUUN3ME20MlkzQTNizszN NEjZWXJUSU6JRWK=
CAL-39 NInQSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHYWZJKSzVyPUSuPVM6QDhizszN NFvDb4VUSU6JRWK=
PC-3 Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zrR2lEPTB;ND65OFY1QCEQvF2= NFq1dpRUSU6JRWK=
A101D M1LESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PzZmlEPTB;ND65Olg3PSEQvF2= NHPFTFRUSU6JRWK=
ES1 NYf6eJhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;nTWM2OD13LkCwNVMh|ryP M2K5PHNCVkeHUh?=
TE-1 M2jFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTVwMEO2OlYh|ryP NHXKXohUSU6JRWK=
KP-N-YN Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm1TI1KSzVyPUWuNFU3PyEQvF2= MmLGV2FPT0WU
EFO-27 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH64O3hKSzVyPUWuNFY{OjlizszN MmXmV2FPT0WU
BT-549 M4TTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\hZpVKSzVyPUWuNFc4OzZizszN NWPWZYpiW0GQR1XS
HLE MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\nOYZKSzVyPUWuNVE4OzRizszN MlXlV2FPT0WU
SW982 NI\ifY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\lb|A3UUN3ME21MlE{Ozd2IN88US=> Mlv1V2FPT0WU
SCC-25 NG\u[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmwO|ZKSzVyPUWuNVkxPDZizszN MmfLV2FPT0WU
SK-MEL-28 NUK3PYQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTVwMkCzNVMh|ryP MoTlV2FPT0WU
CaR-1 M{ThbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTVwMkC3NlYh|ryP Ml;vV2FPT0WU
MLMA NYfO[VRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W0PGlEPTB;NT6yN|Q{PiEQvF2= MmTyV2FPT0WU
VM-CUB-1 NVf6XpBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XDfGlEPTB;NT6yN|Q{QSEQvF2= NHG5SIlUSU6JRWK=
KNS-42 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTNPYtDUUN3ME21MlI3OTZizszN NWrIc3ZnW0GQR1XS
TK10 MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LifGlEPTB;NT6zOlA5PiEQvF2= Mo\WV2FPT0WU
MEG-01 NX2wNmw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnUUFNKSzVyPUWuN|YzPzRizszN MmHhV2FPT0WU
DEL NU\pZmttT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO5WYExUUN3ME21MlM6ODJ|IN88US=> MV\TRW5ITVJ?
SJRH30 NIDieXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDiTWM2OD13LkO5NlE{KM7:TR?= NV35NHBJW0GQR1XS
SK-PN-DW NXmyRXRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13COWlEPTB;NT60N|U5QSEQvF2= Ml23V2FPT0WU
TE-10 NEfZcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W4UWlEPTB;NT60OFg6OyEQvF2= NVHzOXR7W0GQR1XS
KNS-81-FD NU\tcYloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fNZWlEPTB;NT61NFA6OiEQvF2= NVHkRWJ[W0GQR1XS
BHY NGLTcppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTVwNUGwO{DPxE1? M2D5THNCVkeHUh?=
KYSE-270 NVvpNZBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVwNUO1N|Yh|ryP MVTTRW5ITVJ?
NCI-H650 MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXGxeVc3UUN3ME21MlU4OTF2IN88US=> NFK3[HFUSU6JRWK=
L-363 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4naVmlEPTB;NT62PVQ4PiEQvF2= MkXNV2FPT0WU
TCCSUP M4HSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zxOmlEPTB;NT63NVc4QCEQvF2= NX73eGY1W0GQR1XS
SCH M4XqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTVwN{S3Olch|ryP MmTYV2FPT0WU
HTC-C3 M{PMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfjT3dOUUN3ME21Mlc4PjR2IN88US=> M3G2U3NCVkeHUh?=
J-RT3-T3-5 NUHjS2xlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3RTWM2OD13LkiwO|k1KM7:TR?= MoHkV2FPT0WU
Hs-578-T MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljsTWM2OD13LkizOlA4KM7:TR?= MnWyV2FPT0WU
M14 MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVwOE[3NlYh|ryP NFfQN4lUSU6JRWK=
HT-144 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq2WVMzUUN3ME21Mlg3QDN{IN88US=> NEfq[|FUSU6JRWK=
CAL-54 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzBcXRzUUN3ME21Mlk{OzF2IN88US=> MmHyV2FPT0WU
T47D MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XXZmlEPTB;NT65OlEzKM7:TR?= MmHUV2FPT0WU
GB-1 MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTZwMEKwOlgh|ryP M4CycnNCVkeHUh?=
HSC-2 M3fUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK0TWM2OD14LkGyN|U{KM7:TR?= NIO4c5VUSU6JRWK=
SiHa NWLLPI85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jVTWlEPTB;Nj6xOFA6PyEQvF2= M{fIc3NCVkeHUh?=
OMC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjrTWM2OD14LkO1OFQyKM7:TR?= M3XOVnNCVkeHUh?=
HGC-27 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m2eWlEPTB;Nj6zOVc5PiEQvF2= MnG5V2FPT0WU
FTC-133 NGTvenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXWVnRKSzVyPU[uOFY2PTFizszN NHvGT3hUSU6JRWK=
KS-1 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTZwNUKxOFch|ryP MWfTRW5ITVJ?
HT-1080 MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnudGtKUUN3ME22MlU1ODR{IN88US=> MlT2V2FPT0WU
SKG-IIIa NULCdG5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTZwNU[yOlMh|ryP MmHvV2FPT0WU
OCUB-M MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED4b4RKSzVyPU[uOlA4PyEQvF2= NF7HbmhUSU6JRWK=
MDA-MB-175-VII M{jaVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PM[WlEPTB;Nj62NlA6KM7:TR?= MoniV2FPT0WU
BB30-HNC NVn2WZpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfwTWM2OD14Lk[3OFQ1KM7:TR?= NVSySXNtW0GQR1XS
D-542MG NHnpV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH63dHlKSzVyPU[uO|MxQSEQvF2= Mki0V2FPT0WU
NCI-H2405 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIqzU|NKSzVyPU[uO|Q5PTVizszN NV\CVII2W0GQR1XS
SW1573 NGDSbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTZwN{izNVkh|ryP M3O2SnNCVkeHUh?=
NCI-SNU-1 NWLCN3R7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTZwN{mwNlIh|ryP NG\4O|FUSU6JRWK=
RT-112 NF7yNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTZwN{m0OlMh|ryP NFHCSFFUSU6JRWK=
COR-L88 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\VPVVKSzVyPU[uO|k4QTFizszN NGHkPFZUSU6JRWK=
SCC-9 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PacWlEPTB;Nj64NlU2KM7:TR?= MlvjV2FPT0WU
U-87-MG MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3XdW9yUUN3ME22Mlg{QDJ4IN88US=> MmW4V2FPT0WU
Detroit562 NFHUWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nYcWlEPTB;Nj64OVk6OSEQvF2= NHfXUI1USU6JRWK=
LC-2-ad MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLaTWM2OD14Lki2NlkzKM7:TR?= NEnyTG1USU6JRWK=
IGROV-1 NHLWe4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEixeotKSzVyPU[uPVI2QDNizszN MV;TRW5ITVJ?
OVCAR-8 NX\PVW1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofHTWM2OD14Lkm0NlI6KM7:TR?= NUn5RYpYW0GQR1XS
SNU-387 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzO[ZpVUUN3ME22Mlk6PTF4IN88US=> NGizZXRUSU6JRWK=
TGBC1TKB NFHLfXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z3TGlEPTB;Nz6xOVI4PyEQvF2= M{nsenNCVkeHUh?=
NOS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fnNmlEPTB;Nz6yNFQyPSEQvF2= NXyyd2t{W0GQR1XS
HEC-1 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTdwMkWzPFch|ryP NGjncIlUSU6JRWK=
GI-ME-N NUnDdVBwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvFT4pOUUN3ME23MlI6OTV6IN88US=> MmjCV2FPT0WU
KYSE-520 NFu1UopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni0TWM2OD15LkK5Nlkh|ryP MnL5V2FPT0WU
SNU-423 M13XbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLudpZpUUN3ME23MlI6PDV{IN88US=> MVHTRW5ITVJ?
C-33-A MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUSzdXAyUUN3ME23MlQ4QDJizszN NIPK[ZJUSU6JRWK=
SK-UT-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;3fpo6UUN3ME23MlU1QDJ7IN88US=> MWjTRW5ITVJ?
OVCAR-4 M1XYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLkTJhKSzVyPUeuOVUzPiEQvF2= NYTDR4p[W0GQR1XS
KYSE-450 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTdwNkO3PVEh|ryP MVrTRW5ITVJ?
RS4-11 M{[zNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fNSWlEPTB;Nz63NFE6PiEQvF2= MYTTRW5ITVJ?
OVCAR-5 Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfOV4RKUUN3ME23MlgzOzJ7IN88US=> MnLKV2FPT0WU
K5 NYHiPZN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M371fGlEPTB;Nz64O|QzKM7:TR?= NEXHbZpUSU6JRWK=
786-0 M{\YfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzOcpdHUUN3ME24MlA{ODl3IN88US=> NXGwe5FCW0GQR1XS
NCI-H747 MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qwPGlEPTB;OD6wOFQ2PyEQvF2= MWfTRW5ITVJ?
CAL-27 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES3dGxKSzVyPUiuNVI4OiEQvF2= NHj1eYVUSU6JRWK=
FADU NYTxbIZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrFTWM2OD16LkG3OVQ{KM7:TR?= M1fRV3NCVkeHUh?=
SW780 M2fqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;DTWM2OD16LkG4PFIyKM7:TR?= NVzhU40yW0GQR1XS
ACHN NGDaUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRThwMkK1Nlkh|ryP MWnTRW5ITVJ?
TE-6 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRThwMkO3PFgh|ryP NUnue3BZW0GQR1XS
NCI-H2087 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTaTG1HUUN3ME24MlM3OTV6IN88US=> MVrTRW5ITVJ?
NCI-H2122 MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\ITWM2OD16LkSwOFc6KM7:TR?= MoX6V2FPT0WU
SK-LU-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGOw[XZKSzVyPUiuOFM6QTdizszN Mn[zV2FPT0WU
22RV1 NH\TbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH2NJJKSzVyPUiuOlE4QDZizszN NHjkU|dUSU6JRWK=
MEL-JUSO NIfVZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDrWGdKSzVyPUiuOlg3PzVizszN MUjTRW5ITVJ?
UM-UC-3 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHHdpUxUUN3ME24MlcyOzlizszN NEj5c|RUSU6JRWK=
HuH-7 NEnQSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHDTWM2OD16LkezNFEzKM7:TR?= M{WzVXNCVkeHUh?=
SNU-449 MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRThwN{WyOlUh|ryP MlfTV2FPT0WU
RVH-421 NXTQeZF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrm[ZA5UUN3ME24Mlc2Ozl6IN88US=> MUfTRW5ITVJ?
MFM-223 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTJNXNKSzVyPUiuPFA4OzVizszN MWXTRW5ITVJ?
CHP-212 MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\JW3A1UUN3ME24MlgzOjZ5IN88US=> NHXFNXFUSU6JRWK=
NCI-H28 NVP1VXQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfoSmQ4UUN3ME24Mlg2OTh3IN88US=> MmHHV2FPT0WU
C8166 NIrvZ5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljiTWM2OD16Lki2O|czKM7:TR?= M{[1V3NCVkeHUh?=
SCC-15 M{jnTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfh[IFKSzVyPUiuPFcyQTZizszN NIjvc4hUSU6JRWK=
DMS-273 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRThwOEm2NlMh|ryP MX\TRW5ITVJ?
MPP-89 M1P2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWH5N3JMUUN3ME24MlkyOzRzIN88US=> MnXqV2FPT0WU
EW-22 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLhU4k4UUN3ME24MlkyOzh{IN88US=> NITBS4xUSU6JRWK=
RCM-1 NHTqWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jwXGlEPTB;OD65OlQ5PiEQvF2= M3OxW3NCVkeHUh?=
BT-474 NFn5fFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;sTWM2OD16Lkm4PFczKM7:TR?= NFnuTI5USU6JRWK=
TI-73 M17vemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTlwMEO0PVYh|ryP NGPabo9USU6JRWK=
ES3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H6b2lEPTB;OT6wOVE2PiEQvF2= MV\TRW5ITVJ?
NB17 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfm[m5KSzVyPUmuNVQ2OzVizszN NGnJSItUSU6JRWK=
MOLT-16 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf1eJQ2UUN3ME25MlE3PjV3IN88US=> NX7qRZNvW0GQR1XS
TGBC11TKB NYHQdplrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrBSIdKSzVyPUmuNVkzODVizszN MnPiV2FPT0WU
NB12 NXy2NnNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTlwM{SwPFEh|ryP M4HWXHNCVkeHUh?=
MEL-HO NU[2PZdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVO4TnRCUUN3ME25MlQxOiEQvF2= MXvTRW5ITVJ?
HuCCT1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2raTmlEPTB;OT60O|QxPiEQvF2= MUPTRW5ITVJ?
A704 NXL2VlFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTlwNEe3OFUh|ryP NIXwOWlUSU6JRWK=
SW756 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTlwNUWzOlEh|ryP Ml7QV2FPT0WU
SAS M1fudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkThTWM2OD17LkW4OFU2KM7:TR?= MVvTRW5ITVJ?
KINGS-1 M4K5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPmZ5FKSzVyPUmuOlk{PyEQvF2= NXzHdIV[W0GQR1XS
NKM-1 Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOxU4pKSzVyPUmuPFM6PjRizszN MoT1V2FPT0WU
C2BBe1 MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfUTWM2OD17Lki2NlA1KM7:TR?= M17qNnNCVkeHUh?=
A204 NULoVpFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzVTWM2OD17Lki5O|U2KM7:TR?= Mkf6V2FPT0WU
G-401 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTlwOUC0OFkh|ryP NX\oUGpsW0GQR1XS
PFSK-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTlwOUW2Olkh|ryP M3z4OXNCVkeHUh?=
KYSE-410 NIC4bpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj2PG9KSzVyPUGwMlA3OTVizszN MXPTRW5ITVJ?
SK-MEL-2 NXHLfIEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlr5TWM2OD1zMD6xOVg5KM7:TR?= MUnTRW5ITVJ?
NB5 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFyLkW0NFUh|ryP NVTZOItMW0GQR1XS
NTERA-S-cl-D1 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[0UGlEPTB;MUCuOVQ4PSEQvF2= M4XuTHNCVkeHUh?=
MZ2-MEL M{XDbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkj5TWM2OD1zMD62OlIh|ryP MYDTRW5ITVJ?
SF539 M{W2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmGxTWM2OD1zMD63NVg5KM7:TR?= M1:xenNCVkeHUh?=
CAL-120 MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LtPWlEPTB;MUCuO|U6PyEQvF2= M2XBXnNCVkeHUh?=
GR-ST NFSye45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS2U|hKSzVyPUGxMlI6QCEQvF2= M4\XRnNCVkeHUh?=
IA-LM NVr2TY9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PDc2lEPTB;MUGuN|Q5PiEQvF2= NWTndVZ1W0GQR1XS
NCI-H2452 NHrYUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTNU4RtUUN3ME2xNU4{QTJ5IN88US=> M{WxVnNCVkeHUh?=
NCI-H1648 NELQVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFzLkS2Nlkh|ryP MoXHV2FPT0WU
YH-13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LrVmlEPTB;MUGuOFc1OiEQvF2= M{DzcnNCVkeHUh?=
NCI-H2228 NX7rSY5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XJN2lEPTB;MUGuOFkzQCEQvF2= NHfJUmhUSU6JRWK=
LN-405 M4DwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[0TXZVUUN3ME2xNU42QTJ5IN88US=> M{D2fXNCVkeHUh?=
647-V MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnj1TWM2OD1zMT61PVc1KM7:TR?= MVzTRW5ITVJ?
HCC1806 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTKN3JKSzVyPUGxMlYyOzRizszN M3jRcnNCVkeHUh?=
HPAF-II MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzDSphKSzVyPUGxMlg{PTZizszN M4C3bHNCVkeHUh?=
BB49-HNC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHznR|BKSzVyPUGxMlg{PzVizszN NX;ac5FJW0GQR1XS
KGN MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPlTWM2OD1zMT64OVg6KM7:TR?= NFjsVJZUSU6JRWK=
NOMO-1 Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[1NVFKSzVyPUGxMlg2QTdizszN NFjye4VUSU6JRWK=
A388 MmXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFzLki4NFgh|ryP NX;V[2FTW0GQR1XS
Saos-2 NF\zPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF{LkKwNFMh|ryP NH\2VohUSU6JRWK=
SK-HEP-1 MlXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTF{LkK2NVMh|ryP NHz2OFZUSU6JRWK=
HCE-4 NGD2fodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLMNlV1UUN3ME2xNk4zPjl7IN88US=> MnnBV2FPT0WU
NCI-H1581 NFLzPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;tXWlEPTB;MUKuNlgyQSEQvF2= M{TJNXNCVkeHUh?=
NCI-H23 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f1SGlEPTB;MUKuN|EzPSEQvF2= M4DJfnNCVkeHUh?=
NCI-H596 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfNcoZWUUN3ME2xNk41Pzl6IN88US=> NWHpXXc{W0GQR1XS
NB69 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfae5FuUUN3ME2xNk44PTh3IN88US=> MUnTRW5ITVJ?
ChaGo-K-1 NYPBe2IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3FTWM2OD1zMj63OlQ6KM7:TR?= NE\yU2RUSU6JRWK=
EFM-19 NFrxfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\STWM2OD1zMj63O|E4KM7:TR?= MkfHV2FPT0WU
SW962 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTW[5RXUUN3ME2xNk45OjJ|IN88US=> M3zJTnNCVkeHUh?=
KALS-1 NH3Cc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluxTWM2OD1zMz6wPVUh|ryP NYTUfYdLW0GQR1XS
MDA-MB-415 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW4TWM2OD1zMz6xOlA6KM7:TR?= MojKV2FPT0WU
SW684 NGP6[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ZUJVKSzVyPUGzMlE5PjFizszN NGfRcnpUSU6JRWK=
NCI-H2052 NEP2fJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF|LkO4OFgh|ryP MoDHV2FPT0WU
HOP-92 NEXibFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:zOlBGUUN3ME2xN{44QTl5IN88US=> M3fuNXNCVkeHUh?=
OE19 NITNenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPhfItKSzVyPUG0MlAxPzVizszN NUi2O4xsW0GQR1XS
D-392MG M{X6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK0TWM2OD1zND6xNlEyKM7:TR?= M3nINXNCVkeHUh?=
A253 NI\GdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjvO3dKUUN3ME2xOE4zOjVizszN M4TkPXNCVkeHUh?=
NCI-H1155 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nZUGlEPTB;MUSuNlc1PyEQvF2= M1vKOnNCVkeHUh?=
SNB75 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ixOWlEPTB;MUSuN|g6OyEQvF2= NWPsW45kW0GQR1XS
23132-87 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTF2LkizOVMh|ryP MknrV2FPT0WU
Calu-3 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2e3dWlEPTB;MUSuPFc1OyEQvF2= M13QR3NCVkeHUh?=
CW-2 M3X0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTUTWM2OD1zNT6wNlI{KM7:TR?= MYnTRW5ITVJ?
COLO-679 NFPQN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILQcmhKSzVyPUG1MlExOTNizszN NV3sc49qW0GQR1XS
NCI-SNU-5 NVrmc2RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF3LkW1PFkh|ryP NFHlWnlUSU6JRWK=
AN3-CA M17xXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[xNGlEPTB;MUWuOlQ3QCEQvF2= MlTuV2FPT0WU
SF126 NIjjSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF3LkeyPFUh|ryP MXTTRW5ITVJ?
D-247MG M4XxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H5b2lEPTB;MUWuPFU{OyEQvF2= MVPTRW5ITVJ?
UACC-62 M3LBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1q1VGlEPTB;MUWuPVY3KM7:TR?= NUTOfHZ6W0GQR1XS
GP5d M4S4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF4LkGxO|Eh|ryP MoDzV2FPT0WU
HuO-3N1 NILrfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfy[o06UUN3ME2xOk4zPDd|IN88US=> MV\TRW5ITVJ?
NCI-H1092 M3e3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIeySIpKSzVyPUG2MlYzQTdizszN MYnTRW5ITVJ?
HCC1187 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHVPI5VUUN3ME2xOk43PTV5IN88US=> NXS5eFNSW0GQR1XS
G-402 M1ixT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofTTWM2OD1zNj64OVY2KM7:TR?= NXTpdW0zW0GQR1XS
HT55 M4nGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlraTWM2OD1zNj64O|UyKM7:TR?= NXLFemRNW0GQR1XS
NCI-H2009 NEjEcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\vSmlEPTB;MU[uPVI3PiEQvF2= MmnqV2FPT0WU
SH-4 M3v6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1H6dWlEPTB;MU[uPVkzKM7:TR?= NITwO5JUSU6JRWK=
SW1783 MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnsW2xKSzVyPUG2Mlk6QThizszN NHq3bWJUSU6JRWK=
HT Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF5LkG5OlQh|ryP M2HIfnNCVkeHUh?=
CP66-MEL M3\mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF5LkOwNUDPxE1? M1vibXNCVkeHUh?=
BEN NGTMS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2O5bGlEPTB;MUeuOVYzPiEQvF2= MVXTRW5ITVJ?
HCC38 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXPNYZZUUN3ME2xO{44Pjl6IN88US=> MWPTRW5ITVJ?
LAN-6 NILFTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknTTWM2OD1zNz64OFg2KM7:TR?= NET3RZNUSU6JRWK=
RERF-LC-MS MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF5LkmxNlkh|ryP M2jaeXNCVkeHUh?=
NCI-H1770 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTF5Lkm0PVEh|ryP NVvyVpY1W0GQR1XS
LCLC-103H Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXSSnByUUN3ME2xPE4xPTFizszN M132SHNCVkeHUh?=
NCI-H520 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nnTmlEPTB;MUiuN|I5OSEQvF2= MVfTRW5ITVJ?
LU-65 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTF6LkSwOFMh|ryP NEDabHpUSU6JRWK=
SK-MEL-3 NXjEfIp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17zZmlEPTB;MUiuOlY4QSEQvF2= NU\4c25[W0GQR1XS
LK-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\Bc3RKSzVyPUG4Mlc4OjNizszN NGTseotUSU6JRWK=
PANC-08-13 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF6Lke4PFkh|ryP MnHRV2FPT0WU
NCI-H460 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj6TWM2OD1zOD64OFY3KM7:TR?= NHnMfmdUSU6JRWK=
COLO-684 MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfFbZNKSzVyPUG4Mlk6PTZizszN M2rBNHNCVkeHUh?=
RPMI-2650 M133WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF7LkCxNkDPxE1? NIPmfI1USU6JRWK=
NY NX\ZWW5oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5XYhZUUN3ME2xPU4yPTZ5IN88US=> NEjsZ2VUSU6JRWK=
NB7 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v4T2lEPTB;MUmuNVc2OyEQvF2= NHHrUmhUSU6JRWK=
NCI-H358 NHnYWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\sTWM2OD1zOT6yOlc{KM7:TR?= M{HYPXNCVkeHUh?=
MC116 M3LhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTF7LkWzN|Eh|ryP MWXTRW5ITVJ?
MS-1 NEjmXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTF7Lk[xNFMh|ryP MYXTRW5ITVJ?
NCI-H82 NUe4THlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XkZWlEPTB;MUmuOlg4QCEQvF2= M3LYdHNCVkeHUh?=
OCI-AML2 NFu1R3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG4flVOUUN3ME2xPU44ODN{IN88US=> MoD5V2FPT0WU
LS-123 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJyLkCxPVQh|ryP NIPrSmRUSU6JRWK=
PC-14 NYrVNpoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIeydnhKSzVyPUKwMlE5OzRizszN M3r2NXNCVkeHUh?=
NCI-H1703 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\BTmlEPTB;MkCuPFE4OyEQvF2= NFLiZm5USU6JRWK=
Calu-6 NFSyNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJzLkGwNFUh|ryP MYXTRW5ITVJ?
no-11 NX:0cGVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnnPFlpUUN3ME2yNU4yPjB{IN88US=> NVvIVFNRW0GQR1XS
NCI-H727 MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\H[WlEPTB;MkGuN|Q6OyEQvF2= NUTLVZhCW0GQR1XS
DSH1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInuVndKSzVyPUKxMlM5PzlizszN MXTTRW5ITVJ?
KYSE-140 M3r5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJzLkeyO|Eh|ryP NIXRS4ZUSU6JRWK=
RH-1 NEXpV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJzLki4N{DPxE1? NWLRfYNiW0GQR1XS
HAL-01 NHHOXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJ{LkC0NVgh|ryP NIHBepVUSU6JRWK=
RXF393 MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H5fWlEPTB;MkKuNlc5QSEQvF2= M3\YNnNCVkeHUh?=
LS-411N NY\rU4tQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qxNGlEPTB;MkKuNlg3QSEQvF2= MoPJV2FPT0WU
no-10 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPEc5hKSzVyPUKyMlUxODRizszN NUjaV25WW0GQR1XS
MKN7 NH:4bXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHZdY8yUUN3ME2yNk43QDdizszN MV\TRW5ITVJ?
AU565 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;EOZg2UUN3ME2yNk44PDd6IN88US=> NYTVdolWW0GQR1XS
NUGC-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ|LkGxPVkh|ryP M2m5V3NCVkeHUh?=
EW-16 M1PkcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TxWGlEPTB;MkSuNFkzPiEQvF2= MUDTRW5ITVJ?
HCC70 M3vl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTaRmFKSzVyPUK0MlE{OjNizszN NVLkWYt3W0GQR1XS
RPMI-8226 NIrRcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJ2LkOxOVUh|ryP MV7TRW5ITVJ?
CFPAC-1 M{f5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nKdmlEPTB;MkSuOlI4OiEQvF2= MV\TRW5ITVJ?
DoTc2-4510 NVL1eZdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorNTWM2OD1{ND63OVc2KM7:TR?= NI[1c3dUSU6JRWK=
KNS-62 NXfNRldUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrPUZNKSzVyPUK1MlAyQCEQvF2= M3\lcXNCVkeHUh?=
SK-N-DZ MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULl[GpQUUN3ME2yOU4xQTB2IN88US=> MVjTRW5ITVJ?
CAL-85-1 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;1TWM2OD1{NT6xOVQ1KM7:TR?= M1HENHNCVkeHUh?=
JVM-2 M33zZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7PTWM2OD1{NT6yNVIzKM7:TR?= M1n1RnNCVkeHUh?=
NCI-H2347 M2TiOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHexNWlKSzVyPUK1MlQzPDlizszN MkDHV2FPT0WU
P30-OHK NHTSXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\W[GNKSzVyPUK1MlY{OThizszN NHKyVpFUSU6JRWK=
SK-N-FI MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH6TWM2OD1{Nj6xNVYzKM7:TR?= MXjTRW5ITVJ?
CAMA-1 NYPDSZg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjHTWM2OD1{Nj60PFc3KM7:TR?= MXXTRW5ITVJ?
MHH-NB-11 NWnveo9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn1TWM2OD1{Nj61PFUyKM7:TR?= NIPJNW5USU6JRWK=
IST-MEL1 NUTMe4k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fGOmlEPTB;Mk[uO|E4PyEQvF2= MWPTRW5ITVJ?
KARPAS-299 M{Tqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PWS2lEPTB;MkeuOFcxOSEQvF2= NWXp[|M4W0GQR1XS
TE-11 M2W2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf3TWM2OD1{Nz63N|QzKM7:TR?= NVvVUFV4W0GQR1XS
769-P NELTTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnXWIdEUUN3ME2yPE41PTN|IN88US=> MkC0V2FPT0WU
CAL-72 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzqe41tUUN3ME2yPE42PTZzIN88US=> M3zuNnNCVkeHUh?=
NCI-H2342 NVu5R3FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC2TWM2OD1{OT6zPFA{KM7:TR?= NV\2UY9rW0GQR1XS
NCI-H1651 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGyPWpuUUN3ME2yPU45PTB|IN88US=> MoLxV2FPT0WU
OE33 NGr1co5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTNyLkGzOFIh|ryP NGWybFNUSU6JRWK=
HuP-T4 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD1|MT60PFM4KM7:TR?= MY\TRW5ITVJ?
U-118-MG M4rnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnaXmZEUUN3ME2zNk42PDRzIN88US=> MV3TRW5ITVJ?
SN12C NEL4OWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLaPVNKSzVyPUOyMlg5OTVizszN M1fONHNCVkeHUh?=
TE-5 NI\4N41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkewTWM2OD1|Mz6xN|Y5KM7:TR?= M1\COHNCVkeHUh?=
KM-H2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP0TWM2OD1|Mz6xOlk6KM7:TR?= NHzETZVUSU6JRWK=
OVCAR-3 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHzTWM2OD1|Mz60NVI4KM7:TR?= NWHMV|NmW0GQR1XS
NCI-H1304 M1vYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIniSZpKSzVyPUOzMlYxOzZizszN M{PMd3NCVkeHUh?=
LU-135 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;6S4dKSzVyPUOzMlcxQDZizszN NGrY[|BUSU6JRWK=
S-117 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUewS29GUUN3ME2zN{44Ojh4IN88US=> M3X5PHNCVkeHUh?=
NCI-H1755 NY[2W5M2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LTT2lEPTB;M{OuPFEyKM7:TR?= MnnSV2FPT0WU
Mo-T MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\RPY9mUUN3ME2zN{45PTl|IN88US=> MW\TRW5ITVJ?
SK-OV-3 M1\ZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYm4UGVEUUN3ME2zN{45QDV2IN88US=> NGW5cGtUSU6JRWK=
RCC10RGB NWrv[|I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfwVINkUUN3ME2zN{46PDN|IN88US=> M2Li[3NCVkeHUh?=
COLO-680N M3jEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i3[WlEPTB;M{SuNVM6PyEQvF2= NHzSdnpUSU6JRWK=
KURAMOCHI M3jt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz0TWM2OD1|ND62OFI2KM7:TR?= NVPhRmdbW0GQR1XS
NCI-H661 NHPTO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorvTWM2OD1|ND64OFQ5KM7:TR?= MWPTRW5ITVJ?
YAPC MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTsepNFUUN3ME2zOU46PTN|IN88US=> NGjvUVJUSU6JRWK=
NCI-H526 NFPadGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfFfGVKSzVyPUO3MlI4PzJizszN NIX0VpBUSU6JRWK=
A498 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\oNmlEPTB;M{iuNFk2PCEQvF2= M4fiT3NCVkeHUh?=
VMRC-RCZ NF\mXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnRXZZZUUN3ME2zPU4xODV2IN88US=> M2PacnNCVkeHUh?=
HCT-116 MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTN7LkC1PEDPxE1? M3zQenNCVkeHUh?=
COLO-320-HSR MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTRyLkC0NUDPxE1? M{H1R3NCVkeHUh?=
OAW-42 M2jOemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XjOGlEPTB;NECuNFU1OiEQvF2= NXHEb5JFW0GQR1XS
SK-MEL-1 NIruSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTsc5pKSzVyPUSwMlI6OjdizszN M3nuWnNCVkeHUh?=
IST-MES1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nWZWlEPTB;NECuO|Y2OyEQvF2= NVLTU|AxW0GQR1XS
CP50-MEL-B MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LLO2lEPTB;NEGuNFc6PyEQvF2= NVjCZopJW0GQR1XS
RMG-I NYfQcm1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf3NWk3UUN3ME20Nk41QTJzIN88US=> MUTTRW5ITVJ?
D-336MG NFfFNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjtTWM2OD12Mz6xNVUzKM7:TR?= MnnZV2FPT0WU
SHP-77 M3Ts[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR|LkG4Nlgh|ryP NUG0TYFXW0GQR1XS
SW872 NHXYcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moe0TWM2OD12Mz6yNVI{KM7:TR?= MYDTRW5ITVJ?
DBTRG-05MG MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfzcHNKSzVyPUS0MlY6QTZizszN MWfTRW5ITVJ?
COLO-678 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTzUm5KSzVyPUS1MlcxOzJizszN M{\tTXNCVkeHUh?=
EGI-1 NXywNnlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTR5LkG4N|Mh|ryP MUXTRW5ITVJ?
KYSE-70 NHXxXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTxRlRKSzVyPUS3MlczOjJizszN NFj5NXZUSU6JRWK=
BALL-1 NI\VfIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TuPGlEPTB;NEeuPFI2PCEQvF2= NWPoW2xuW0GQR1XS
MDA-MB-361 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvCN|JKSzVyPUS4MlA1PiEQvF2= NEjHZ41USU6JRWK=
NCI-H1838 NW\CdW95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvJTWM2OD12OD6zOFU5KM7:TR?= NGXXTnlUSU6JRWK=
NCI-H1573 NYXuWJZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7rTXQ3UUN3ME20PE43Pzh3IN88US=> MWDTRW5ITVJ?
HCC1395 NH3LZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHBTWM2OD12OD65PVIh|ryP NGewdFhUSU6JRWK=
NCI-H2291 M3vwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPCbVhRUUN3ME20PU42QTh6IN88US=> MnnDV2FPT0WU
RH-18 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH2TWM2OD13MD6wPFg1KM7:TR?= MXvTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

17040210 28415756 25395420
Immunofluorescence
PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

25002506
Growth inhibition assay
Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

28415756

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products

Tags: buy BI-D1870 | BI-D1870 supplier | purchase BI-D1870 | BI-D1870 cost | BI-D1870 manufacturer | order BI-D1870 | BI-D1870 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID