BI-D1870

For research use only.

Catalog No.S2843

25 publications

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

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Selleck's BI-D1870 has been cited by 25 publications

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NGLMXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3qNpNKSzVyPUCuNFM2QCEQvF2= NIXZRXhUSU6JRWK=
H9 NYT5RZp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Tjd2lEPTB;MD6wOlAyQSEQvF2= MVLTRW5ITVJ?
KARPAS-45 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwMU[1NlUh|ryP NWjaOG1xW0GQR1XS
NCI-H720 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrHR4dSUUN3ME2wMlE4OTl2IN88US=> MXjTRW5ITVJ?
CTV-1 NUS4[opUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPtTWM2OD1yLkS3PFczKM7:TR?= NX24[Yh3W0GQR1XS
DU-4475 M4C0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rBW2lEPTB;MD61NFQyPyEQvF2= M4XJd3NCVkeHUh?=
A172 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3VT|NbUUN3ME2wMlUyPzB3IN88US=> MmHxV2FPT0WU
EW-18 MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvzSVFKSzVyPUCuOlIzOTFizszN MUjTRW5ITVJ?
KU812 NWDjSHAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrFU3JKSzVyPUCuOlI3OjNizszN Mm[yV2FPT0WU
KP-N-YS NWThWXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXDTWM2OD1yLk[4NlI{KM7:TR?= NHnGbYFUSU6JRWK=
SBC-1 MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfpRYNKSzVyPUCuOlk2OjRizszN NFfUU5VUSU6JRWK=
ECC10 NEPvOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnhTWM2OD1yLkewNFk1KM7:TR?= MX\TRW5ITVJ?
GAMG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwN{S3NVch|ryP NYHKWphDW0GQR1XS
NCI-H209 M2fjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPicVJKSzVyPUCuO|Y5OiEQvF2= MkTSV2FPT0WU
MC-IXC M1XmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwN{m1PFkh|ryP MUjTRW5ITVJ?
HSC-3 M{fXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q1SGlEPTB;MD64NVc3QSEQvF2= MmLIV2FPT0WU
IST-SL1 M4fSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SyUmlEPTB;MD64OFU4PCEQvF2= NImydmtUSU6JRWK=
LU-139 Ml65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnRUWpKSzVyPUCuPFQ6PThizszN M3Xv[nNCVkeHUh?=
ML-2 MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LYOGlEPTB;MD64OVU4PSEQvF2= NX;wSW1RW0GQR1XS
CAL-62 M2rFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXwTWM2OD1yLki4NVUzKM7:TR?= M1fwWnNCVkeHUh?=
HL-60 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwOEizOlIh|ryP MmHuV2FPT0WU
KY821 M1jNSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjtVm5rUUN3ME2wMlg5QDF{IN88US=> M{O5UnNCVkeHUh?=
ES7 NYntVJBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DvTWlEPTB;MD65NVYxPyEQvF2= NXz2VWI5W0GQR1XS
MV-4-11 M2fxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;FTWM2OD1yLkm3PFk4KM7:TR?= Mk\xV2FPT0WU
Daoy MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHtTWM2OD1yLkm4O|Y4KM7:TR?= MkPrV2FPT0WU
EoL-1-cell MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH32PGRKSzVyPUGuNFE5PzhizszN Mkm0V2FPT0WU
TGW MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjoTWM2OD1zLkC1NVI1KM7:TR?= NU\1N4dXW0GQR1XS
LAMA-84 NWLGVFlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HhW2lEPTB;MT6xNlc6PCEQvF2= M{LIPHNCVkeHUh?=
KOSC-2 NFnwTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLGTWM2OD1zLkGzN|g2KM7:TR?= MmXCV2FPT0WU
A549 NEnPRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnOyTWM2OD1zLkOwPVU2KM7:TR?= MkH3V2FPT0WU
CTB-1 M{mwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LFcGlEPTB;MT60OFY4QSEQvF2= MXHTRW5ITVJ?
NCI-H292 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XxdmlEPTB;MT60OlA3QSEQvF2= NYGwN2V2W0GQR1XS
LoVo M2C5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHjSmZ{UUN3ME2xMlQ3PzV3IN88US=> MonLV2FPT0WU
BFTC-905 MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwNU[zN|Ih|ryP M4DhOnNCVkeHUh?=
BE-13 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwNUi3NFkh|ryP MlvVV2FPT0WU
KE-37 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jQOGlEPTB;MT61PVQ4QCEQvF2= Mo[xV2FPT0WU
HN M{DEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HHW2lEPTB;MT62NVM3QCEQvF2= NYfjO2xIW0GQR1XS
A3-KAW M{PsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7oSVV5UUN3ME2xMlYzQDN2IN88US=> NITPdVRUSU6JRWK=
NEC8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fwbGlEPTB;MT63NFEyPSEQvF2= NH61fG9USU6JRWK=
Ramos-2G6-4C10 NFfTZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r6dmlEPTB;MT63NFQ1PCEQvF2= MWXTRW5ITVJ?
NB10 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni2TWM2OD1zLke3OlMh|ryP NETQbVhUSU6JRWK=
NBsusSR NHX0cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFwOEK5OlEh|ryP NEP6TlBUSU6JRWK=
ES4 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zLSWlEPTB;MT64OVE1OyEQvF2= MonpV2FPT0WU
ES8 NXXDdpVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHBdJhKSzVyPUGuPFc4OjRizszN M1q1bHNCVkeHUh?=
CHL-1 M{nqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFyzOVdKSzVyPUGuPVU4QTJizszN NY\0T5kyW0GQR1XS
NCI-H2029 M2TXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nZdGlEPTB;MT65O|I1OSEQvF2= NUTr[nBCW0GQR1XS
YKG-1 M4PTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLxflBrUUN3ME2xMlk5PDN{IN88US=> MYrTRW5ITVJ?
BV-173 NHq1V3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXucmpoUUN3ME2xMlk5PjZ4IN88US=> NEXqSZZUSU6JRWK=
697 M{nqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK4OohKSzVyPUKuNFIzOjhizszN MVrTRW5ITVJ?
SK-NEP-1 MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwMES0JO69VQ>? M{\DTXNCVkeHUh?=
LOXIMVI M1exd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfWdItKSzVyPUKuNFQ1OzRizszN M2XYOnNCVkeHUh?=
QIMR-WIL NFvkV3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrDVllkUUN3ME2yMlA4QDR7IN88US=> MYfTRW5ITVJ?
DU-145 MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LpdmlEPTB;Mj6xNVA2PiEQvF2= Moi3V2FPT0WU
NB14 M17lW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTHUFNPUUN3ME2yMlEyOzJzIN88US=> NULsR45qW0GQR1XS
G-361 NEDzOlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTJwMUKyNUDPxE1? Mn3XV2FPT0WU
BPH-1 NVvoTHhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJwMUK5OVch|ryP M1vSdHNCVkeHUh?=
KYSE-150 NIPDTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFT3d2ZKSzVyPUKuNVUzOzRizszN Mo\YV2FPT0WU
HMV-II M3Hzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD5TWM2OD1{LkG2OlM{KM7:TR?= MUjTRW5ITVJ?
TE-9 NIX4bVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDSS2ZtUUN3ME2yMlE4Ozd4IN88US=> M13BO3NCVkeHUh?=
8-MG-BA NIe3WFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\ucm1KSzVyPUKuNlM1PjFizszN NXLhb4liW0GQR1XS
ES5 M4j6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHw[XJ[UUN3ME2yMlI{PjN|IN88US=> M1G0cHNCVkeHUh?=
D-283MED MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nLbmlEPTB;Mj6yN|Y6PSEQvF2= NVHPOWI3W0GQR1XS
SK-N-AS NXW0PWUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj6OHg2UUN3ME2yMlI6ODV7IN88US=> Mn;CV2FPT0WU
SW1710 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3MTWM2OD1{LkOwOlYyKM7:TR?= NILlO|hUSU6JRWK=
GCT M1fHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfEPGRKSzVyPUKuN|E{PThizszN NUjnbmR{W0GQR1XS
AGS M{DR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwM{S0NFQh|ryP M{HjfXNCVkeHUh?=
HuO9 NXnOUppzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDDT4xCUUN3ME2yMlM3QDJ2IN88US=> NUno[mw3W0GQR1XS
MN-60 NFO3[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDjTWM2OD1{LkS0PFg{KM7:TR?= NYTYeYhqW0GQR1XS
NB6 NEDDVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTJwNEW3O|kh|ryP NXW2dJN{W0GQR1XS
NCI-H1395 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwNEexNlEh|ryP M{PFTXNCVkeHUh?=
H4 M3izPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJwNEizPVMh|ryP MkfDV2FPT0WU
HT-3 M{TlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXOdYV4UUN3ME2yMlUyODJ2IN88US=> M1jle3NCVkeHUh?=
P12-ICHIKAWA Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjDNGhKSzVyPUKuOVI2PTlizszN Mnz3V2FPT0WU
COLO-800 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJwNUSxOlYh|ryP MX\TRW5ITVJ?
DB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwNUWwNVMh|ryP MXzTRW5ITVJ?
LCLC-97TM1 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DGe2lEPTB;Mj62NFAzQCEQvF2= M1jSenNCVkeHUh?=
Ca9-22 NEC1OmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3THeGlEPTB;Mj62OVk{OyEQvF2= NIHqTGVUSU6JRWK=
Becker NH3MfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLjTWM2OD1{Lk[2NFc5KM7:TR?= NFPudXFUSU6JRWK=
ACN MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJwNk[3PUDPxE1? NFexW3dUSU6JRWK=
SJSA-1 M1[yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojtTWM2OD1{Lk[2PFch|ryP MmL5V2FPT0WU
NCI-H1048 NIT0b4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSzOYU4UUN3ME2yMlY5OzJzIN88US=> Mn;IV2FPT0WU
HEL MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHSbIF5UUN3ME2yMlcxOjV2IN88US=> MUPTRW5ITVJ?
NCI-H69 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwN{G2NFEh|ryP NIX1VlhUSU6JRWK=
639-V NGP2cmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlywTWM2OD1{LkexO|A{KM7:TR?= NX\uXm9MW0GQR1XS
U251 MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoWxTWM2OD1{LkezNFMzKM7:TR?= NUiyUGliW0GQR1XS
NCI-H1792 NFjTdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;YS5lMUUN3ME2yMlc{PzN6IN88US=> NXf5bZRiW0GQR1XS
EW-1 MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOw[XNKSzVyPUKuO|U{OjhizszN MXfTRW5ITVJ?
ME-180 M2H5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJwN{e3N|Yh|ryP MXPTRW5ITVJ?
HH Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TVTGlEPTB;Mj64NFAxOSEQvF2= MlHnV2FPT0WU
SW954 NXTUfZlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJwOEW4N{DPxE1? MVLTRW5ITVJ?
SF268 M4TZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwOEeyNlUh|ryP MXrTRW5ITVJ?
D-566MG NWSwPZZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG2NodTUUN3ME2yMlkyOjl3IN88US=> NHnyVGZUSU6JRWK=
EM-2 NVLIUVF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJwOUKxPVMh|ryP MYXTRW5ITVJ?
NCI-H1299 NFjIVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHOe2RKSzVyPUKuPVM4OzZizszN NIe3fZJUSU6JRWK=
PSN1 NU\HV4VOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\GfHBKSzVyPUOuNFU4QDZizszN NIfUWJRUSU6JRWK=
JVM-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHVWm1KSzVyPUOuNFY4PTZizszN NI\wSoRUSU6JRWK=
D-502MG MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfCUpRJUUN3ME2zMlA4ODF7IN88US=> MknsV2FPT0WU
SCC-4 NFuxZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\QUXF1UUN3ME2zMlA6Ojd4IN88US=> MlPPV2FPT0WU
GMS-10 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\GeWlEPTB;Mz6wPVM5QCEQvF2= NUHFXXlTW0GQR1XS
A427 MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTNwMUC4O|Mh|ryP MmThV2FPT0WU
NH-12 MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXTTWM2OD1|LkGxOFU3KM7:TR?= MmC3V2FPT0WU
KM12 M3z3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36wNmlEPTB;Mz6xNlI4OyEQvF2= Mmn0V2FPT0WU
GI-1 Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLUXHNKSzVyPUOuNVUzPTVizszN MnfiV2FPT0WU
TE-8 NU[2b3lET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W0[mlEPTB;Mz6xPVI{OSEQvF2= NIfpT2lUSU6JRWK=
MKN1 NVvxfYpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLzTWM2OD1|LkKwPFc2KM7:TR?= MmPsV2FPT0WU
NCI-H810 NXzqR2d1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHr3WG9KSzVyPUOuNlIyPTVizszN MYjTRW5ITVJ?
GOTO M4PFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nzTmlEPTB;Mz6yPFAxPCEQvF2= M1PtfnNCVkeHUh?=
T98G MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjKT4dKUUN3ME2zMlI5OjF4IN88US=> Ml3SV2FPT0WU
HD-MY-Z MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPsNnNKSzVyPUOuN|Y2PDJizszN MnnFV2FPT0WU
SNU-C2B M4Da[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHm4cXJKSzVyPUOuN|kxQTdizszN Mlr2V2FPT0WU
MOLT-4 NX\PO4lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXPWlFFUUN3ME2zMlM6ODl6IN88US=> M1vPWnNCVkeHUh?=
RPMI-7951 NVXFe|lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\ZOWlEPTB;Mz6zPVc{KM7:TR?= MlTrV2FPT0WU
EW-11 NGf0ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfXSFNKSzVyPUOuOFEzOjRizszN NVLRWlcxW0GQR1XS
RD NEnwRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNwNEOxN|Ih|ryP MmfIV2FPT0WU
SW48 M{GzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XTOGlEPTB;Mz60N|M2QCEQvF2= MlK1V2FPT0WU
BB65-RCC NVmz[JVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P4VGlEPTB;Mz60OVM6PiEQvF2= MUXTRW5ITVJ?
Ca-Ski NX:ycmlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTNwNEe1NVQh|ryP MWPTRW5ITVJ?
CHP-134 M4nRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTK[JVKSzVyPUOuOFg4PThizszN NIe5elJUSU6JRWK=
CAL-33 NFjvZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXNTWM2OD1|LkWzN|YzKM7:TR?= NFfkPHdUSU6JRWK=
TYK-nu M1XKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzsPVJtUUN3ME2zMlU{Pjd4IN88US=> MWDTRW5ITVJ?
LB831-BLC NIPSRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\lPVhKSzVyPUOuOVQxOTZizszN M4HCVnNCVkeHUh?=
KU-19-19 M3HMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHezZpJKSzVyPUOuOlA{ODRizszN NV3Fd4hVW0GQR1XS
KG-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\yV2FKSzVyPUOuOlEyODZizszN NUPJcJp[W0GQR1XS
COLO-829 Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX3PXgyUUN3ME2zMlY3PjF6IN88US=> MWXTRW5ITVJ?
HUTU-80 NH64bnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTNwNk[2NlEh|ryP MWTTRW5ITVJ?
NCI-H446 M3PQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTNwNkizOEDPxE1? MUHTRW5ITVJ?
LB2241-RCC MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTNwNki2NlUh|ryP NGXTR3hUSU6JRWK=
JEG-3 NXvVWmh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTNwNkmxPUDPxE1? NELaU|hUSU6JRWK=
LNCaP-Clone-FGC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrvS2l1UUN3ME2zMlcxODRzIN88US=> NEfoWmlUSU6JRWK=
M059J M1LDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnFOGxKSzVyPUOuO|E1PjhizszN MX3TRW5ITVJ?
SK-MES-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fUNGlEPTB;Mz63N|A{KM7:TR?= MXTTRW5ITVJ?
GT3TKB Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfENXZKSzVyPUOuO|U3ODRizszN M1O3U3NCVkeHUh?=
DOK NFrUUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTNwN{[1NlYh|ryP MnzjV2FPT0WU
HO-1-N-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2faZWlEPTB;Mz63PVgxOSEQvF2= NH;kcWRUSU6JRWK=
MZ1-PC NIDLXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXRRYxTUUN3ME2zMlgzQDh|IN88US=> M3nlWnNCVkeHUh?=
8305C MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrFcItFUUN3ME2zMlg5QTR|IN88US=> NH;uZYxUSU6JRWK=
CGTH-W-1 M{OyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTNwOUO1NFQh|ryP MVrTRW5ITVJ?
LU-134-A NIm0OGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL6TWM2OD1|Lkm1OFIzKM7:TR?= NGfZTXpUSU6JRWK=
C32 M3nHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNwOU[1PFEh|ryP NXq5OW5KW0GQR1XS
MOLT-13 NYX1WoY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\JV4w1UUN3ME2zMlk3QDV4IN88US=> MX;TRW5ITVJ?
A375 M3vzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES5OXZKSzVyPUSuNFUyPjJizszN NI\DdoJUSU6JRWK=
CAL-12T MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTFRol7UUN3ME20MlA2Pzl3IN88US=> NE\mRmJUSU6JRWK=
IGR-1 NH3B[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTRwMUCyO|Qh|ryP NU\HdnRQW0GQR1XS
LB1047-RCC M2j2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTRwMUC0OFEh|ryP NHjubVRUSU6JRWK=
BHT-101 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjBVXlKSzVyPUSuNVA3QDNizszN M3;B[HNCVkeHUh?=
A431 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTPTWM2OD12LkG0NFgyKM7:TR?= NYHib5U2W0GQR1XS
EPLC-272H NYW4UmRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXNVmF7UUN3ME20MlE4PTl4IN88US=> MkW1V2FPT0WU
HT-1376 NF3CcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVewc2liUUN3ME20MlI{ODV7IN88US=> NYHpbG5FW0GQR1XS
HCC1954 M{nBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrIPI8zUUN3ME20MlI2PzR4IN88US=> NE[1SI5USU6JRWK=
KYSE-510 M4\abWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr0b45KSzVyPUSuNlYxQSEQvF2= NULib5hpW0GQR1XS
PANC-03-27 NV7GZWZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfPNmFuUUN3ME20MlMxODh|IN88US=> NVWzSlFSW0GQR1XS
MDA-MB-157 NULY[2JZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmX3TWM2OD12LkOwOlU3KM7:TR?= MnnyV2FPT0WU
HOP-62 NXW1fYp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTRwM{C4OVYh|ryP MYHTRW5ITVJ?
ETK-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTRwM{[yNFMh|ryP NX\KU2JJW0GQR1XS
MIA-PaCa-2 NVTPdZZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\aTWM2OD12LkO2NlI4KM7:TR?= NVH6NJFXW0GQR1XS
MHH-PREB-1 NHTi[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTRwM{m3O|Mh|ryP NXPCN|NXW0GQR1XS
LXF-289 NYrDUIdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TJXGlEPTB;ND60NFIxOiEQvF2= MojVV2FPT0WU
ATN-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Dqc2lEPTB;ND60NlM1OSEQvF2= MULTRW5ITVJ?
8505C NWrWZ4htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LDdWlEPTB;ND60OVgzPSEQvF2= NXLaOZNwW0GQR1XS
HOS NHXVeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz0RpBKSzVyPUSuOFY1PTNizszN NEfj[2RUSU6JRWK=
U-266 NFHrPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj6bJJKSzVyPUSuOlExOzJizszN M3W4SnNCVkeHUh?=
5637 NF7HVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjCRVFKSzVyPUSuOlE1PDRizszN MXXTRW5ITVJ?
GCIY M4S1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTIN2tqUUN3ME20MlcyODF3IN88US=> M4rDZnNCVkeHUh?=
MDA-MB-231 NGLmZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX6TWM2OD12LkeyNVE2KM7:TR?= MXLTRW5ITVJ?
RKO M4PJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2r3dWlEPTB;ND63NlgyPyEQvF2= NUPaPINzW0GQR1XS
COR-L23 NU[3[GFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;IWWlEPTB;ND63OFI2PiEQvF2= NG\3VJlUSU6JRWK=
DJM-1 MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELaR4pKSzVyPUSuO|k4OjlizszN NYfPcGQ1W0GQR1XS
D-423MG NVPNVFZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrHWItKSzVyPUSuPFA5ODNizszN Mk\OV2FPT0WU
DMS-114 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfLTWM2OD12LkixN|g3KM7:TR?= NFv1WG9USU6JRWK=
MHH-ES-1 NUXMdJhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknRTWM2OD12LkiyOVA1KM7:TR?= M3\3OHNCVkeHUh?=
CAL-51 M1nJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPlfIZKSzVyPUSuPFY5PDNizszN NFPEV4VUSU6JRWK=
SW626 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWzU2NKSzVyPUSuPFk3QTdizszN M2K3V3NCVkeHUh?=
COLO-824 M321XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLtNW5KSzVyPUSuPVA1ODhizszN NGnNfIhUSU6JRWK=
NCI-H1437 NUjaUppCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LQXWlEPTB;ND65Nlk{KM7:TR?= M3T3NHNCVkeHUh?=
CAL-39 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfQOYVFUUN3ME20Mlk{QTh6IN88US=> MYXTRW5ITVJ?
PC-3 NHTTSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[2[JNlUUN3ME20Mlk1PjR6IN88US=> MmfOV2FPT0WU
A101D MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;WTWM2OD12Lkm2PFY2KM7:TR?= NEnyfJJUSU6JRWK=
ES1 NWjCcm1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDRWmtOUUN3ME21MlAxOTNizszN NXLjdIV4W0GQR1XS
TE-1 NFfRWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nEUGlEPTB;NT6wN|Y3PiEQvF2= NWHWZ2lEW0GQR1XS
KP-N-YN M1zxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjEbY5KSzVyPUWuNFU3PyEQvF2= MXHTRW5ITVJ?
EFO-27 Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\UZ3NtUUN3ME21MlA3OzJ7IN88US=> MVPTRW5ITVJ?
BT-549 NEHvXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zvWGlEPTB;NT6wO|c{PiEQvF2= Mkn3V2FPT0WU
HLE MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDNOWg1UUN3ME21MlEyPzN2IN88US=> MnLnV2FPT0WU
SW982 M{PQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVqzXW9EUUN3ME21MlE{Ozd2IN88US=> NIDubm5USU6JRWK=
SCC-25 NXrlb3dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7NVolsUUN3ME21MlE6ODR4IN88US=> NYfP[Fh{W0GQR1XS
SK-MEL-28 MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO4TWM2OD13LkKwN|E{KM7:TR?= NH3lNIdUSU6JRWK=
CaR-1 NYrFNJRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWxNpJKSzVyPUWuNlA4OjZizszN NIXhUoxUSU6JRWK=
MLMA MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XWcWlEPTB;NT6yN|Q{PiEQvF2= M1y0dXNCVkeHUh?=
VM-CUB-1 MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u2b2lEPTB;NT6yN|Q{QSEQvF2= MULTRW5ITVJ?
KNS-42 M4L0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjSfGpKSzVyPUWuNlYyPiEQvF2= MV3TRW5ITVJ?
TK10 M4LvXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTwTWM2OD13LkO2NFg3KM7:TR?= Ml3zV2FPT0WU
MEG-01 NFTvflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCyTWM2OD13LkO2Nlc1KM7:TR?= M4jNNXNCVkeHUh?=
DEL NF3iUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTVwM{mwNlMh|ryP MlO2V2FPT0WU
SJRH30 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHBOIFjUUN3ME21MlM6OjF|IN88US=> NEX2eJVUSU6JRWK=
SK-PN-DW NVq3OHNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTENpRTUUN3ME21MlQ{PTh7IN88US=> Mn3OV2FPT0WU
TE-10 M3XaR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fzVWlEPTB;NT60OFg6OyEQvF2= NYSzUFhvW0GQR1XS
KNS-81-FD MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTVwNUCwPVIh|ryP MomyV2FPT0WU
BHY NVr3NI9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml20TWM2OD13LkWxNFch|ryP NV\5WFI{W0GQR1XS
KYSE-270 NHH6[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnJOohKSzVyPUWuOVM2OzZizszN NFHFR5JUSU6JRWK=
NCI-H650 M3\1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLzTWM2OD13LkW3NVE1KM7:TR?= MlOwV2FPT0WU
L-363 M4m1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i0NmlEPTB;NT62PVQ4PiEQvF2= MnuzV2FPT0WU
TCCSUP NUDPbm92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTMeo5JUUN3ME21MlcyPzd6IN88US=> M4L3[nNCVkeHUh?=
SCH NWTjUoVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TLUGlEPTB;NT63OFc3PyEQvF2= NXzDRo5OW0GQR1XS
HTC-C3 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHVTWM2OD13Lke3OlQ1KM7:TR?= MYLTRW5ITVJ?
J-RT3-T3-5 NYPXfo52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzkUFdGUUN3ME21MlgxPzl2IN88US=> MY\TRW5ITVJ?
Hs-578-T M332d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHEV3VUUUN3ME21Mlg{PjB5IN88US=> MnS1V2FPT0WU
M14 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{OzV2lEPTB;NT64OlczPiEQvF2= MX\TRW5ITVJ?
HT-144 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTVwOE[4N|Ih|ryP MkjlV2FPT0WU
CAL-54 NX[5d3l2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT5doNKSzVyPUWuPVM{OTRizszN MknCV2FPT0WU
T47D Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK0TWM2OD13Lkm2NVIh|ryP MoniV2FPT0WU
GB-1 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3oTWM2OD14LkCyNFY5KM7:TR?= NGXHOlhUSU6JRWK=
HSC-2 NWO4SHN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\wZWlEPTB;Nj6xNlM2OyEQvF2= MUHTRW5ITVJ?
SiHa NGjJfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HwZ2lEPTB;Nj6xOFA6PyEQvF2= NGrTb2JUSU6JRWK=
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HGC-27 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[3TWM2OD14LkO1O|g3KM7:TR?= M3TWSHNCVkeHUh?=
FTC-133 NUm0PYx7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWyTWM2OD14LkS2OVUyKM7:TR?= MmHjV2FPT0WU
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HT-1080 MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HnO2lEPTB;Nj61OFA1OiEQvF2= NHzlTo5USU6JRWK=
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MDA-MB-175-VII MkPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWO0[lRLUUN3ME22MlYzODlizszN NEezbHdUSU6JRWK=
BB30-HNC M4O3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTZwNke0OFQh|ryP M2XGUnNCVkeHUh?=
D-542MG NIG4cIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL6TWM2OD14LkezNFkh|ryP NXfjS4hFW0GQR1XS
NCI-H2405 NV23e3dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP0TWM2OD14Lke0PFU2KM7:TR?= M2Lh[HNCVkeHUh?=
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RT-112 NU\zfIxPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILMWm1KSzVyPU[uO|k1PjNizszN MX;TRW5ITVJ?
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SCC-9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH4UGVKSzVyPU[uPFI2PSEQvF2= NUPXW4wyW0GQR1XS
U-87-MG M{jXcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\KTFFmUUN3ME22Mlg{QDJ4IN88US=> MmDpV2FPT0WU
Detroit562 NUfS[2oxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXjc2Z1UUN3ME22Mlg2QTlzIN88US=> NFe5VmZUSU6JRWK=
LC-2-ad NX\qNlVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTZwOE[yPVIh|ryP M2DkO3NCVkeHUh?=
IGROV-1 MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTZwOUK1PFMh|ryP MVjTRW5ITVJ?
OVCAR-8 NHGzW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTZwOUSyNlkh|ryP MUTTRW5ITVJ?
SNU-387 NX6zUpZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[wZ2lEPTB;Nj65PVUyPiEQvF2= M4eyWHNCVkeHUh?=
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HEC-1 NH;WOZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj5TpNKSzVyPUeuNlU{QDdizszN M3mxRnNCVkeHUh?=
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KYSE-520 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTdwMkmyPUDPxE1? MULTRW5ITVJ?
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KYSE-450 NVXMeZBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HUd2lEPTB;Nz62N|c6OSEQvF2= MlnhV2FPT0WU
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NCI-H747 NYjS[pVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGy[5RwUUN3ME24MlA1PDV5IN88US=> MmTNV2FPT0WU
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TI-73 NXPXN|dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK5PJh7UUN3ME25MlA{PDl4IN88US=> MnTOV2FPT0WU
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SF539 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\WcZlTUUN3ME2xNE44OTh6IN88US=> M{e0NnNCVkeHUh?=
CAL-120 M{jpZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVztblBqUUN3ME2xNE44PTl5IN88US=> Mlu2V2FPT0WU
GR-ST MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rGTGlEPTB;MUGuNlk5KM7:TR?= NH\IV5hUSU6JRWK=
IA-LM M1LVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rnWWlEPTB;MUGuN|Q5PiEQvF2= NXLDXo1DW0GQR1XS
NCI-H2452 M4nUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrteVdwUUN3ME2xNU4{QTJ5IN88US=> Mn\5V2FPT0WU
NCI-H1648 NY\mVpJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFzLkS2Nlkh|ryP NXjMZpV3W0GQR1XS
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NCI-H2228 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TyU2lEPTB;MUGuOFkzQCEQvF2= M{e2OHNCVkeHUh?=
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SK-HEP-1 MoCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HlV2lEPTB;MUKuNlYyOyEQvF2= M{i0enNCVkeHUh?=
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NCI-H1581 M1LuZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TvSWlEPTB;MUKuNlgyQSEQvF2= MY\TRW5ITVJ?
NCI-H23 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF{LkOxNlUh|ryP NGP5U5FUSU6JRWK=
NCI-H596 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXFWYpYUUN3ME2xNk41Pzl6IN88US=> MWnTRW5ITVJ?
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MDA-MB-415 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TJcGlEPTB;MUOuNVYxQSEQvF2= MWHTRW5ITVJ?
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NCI-H2052 NVHnb|BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O1V2lEPTB;MUOuN|g1QCEQvF2= NILx[YJUSU6JRWK=
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D-392MG M{HYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vDeGlEPTB;MUSuNVIyOSEQvF2= MoixV2FPT0WU
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23132-87 Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF2LkizOVMh|ryP NYjUTm5TW0GQR1XS
Calu-3 NVrLVoFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTGTWM2OD1zND64O|Q{KM7:TR?= MoWxV2FPT0WU
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NCI-SNU-5 M2Pwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTyTWM2OD1zNT61OVg6KM7:TR?= NHm1UYlUSU6JRWK=
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SF126 NEOz[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF3LkeyPFUh|ryP NUG5V412W0GQR1XS
D-247MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[4dWlEPTB;MUWuPFU{OyEQvF2= NUHneGRiW0GQR1XS
UACC-62 NI\NXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF3Lkm2OkDPxE1? MUPTRW5ITVJ?
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HuO-3N1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPXNHNqUUN3ME2xOk4zPDd|IN88US=> NHXvc2JUSU6JRWK=
NCI-H1092 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjCXlRrUUN3ME2xOk43Ojl5IN88US=> MW\TRW5ITVJ?
HCC1187 MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTpTWM2OD1zNj62OVU4KM7:TR?= MojtV2FPT0WU
G-402 M4\2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fLdWlEPTB;MU[uPFU3PSEQvF2= NWjFdmJKW0GQR1XS
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NCI-H2009 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M124dmlEPTB;MU[uPVI3PiEQvF2= MVHTRW5ITVJ?
SH-4 NHfV[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP3RlRKSzVyPUG2Mlk6OiEQvF2= NYexdYpWW0GQR1XS
SW1783 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jiT2lEPTB;MU[uPVk6QCEQvF2= M1jv[HNCVkeHUh?=
HT NYTjfoZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PXTGlEPTB;MUeuNVk3PCEQvF2= MU\TRW5ITVJ?
CP66-MEL MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljMTWM2OD1zNz6zNFEh|ryP M4jzSnNCVkeHUh?=
BEN M4LPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\oWpVKSzVyPUG3MlU3OjZizszN MX;TRW5ITVJ?
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LAN-6 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXpTWM2OD1zNz64OFg2KM7:TR?= NH7TfXZUSU6JRWK=
RERF-LC-MS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvQdHBFUUN3ME2xO{46OTJ7IN88US=> NWHLcFl4W0GQR1XS
NCI-H1770 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3qTWM2OD1zNz65OFkyKM7:TR?= MYPTRW5ITVJ?
LCLC-103H MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF6LkC1NUDPxE1? MYDTRW5ITVJ?
NCI-H520 NYrFTo9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjnTWM2OD1zOD6zNlgyKM7:TR?= MUTTRW5ITVJ?
LU-65 NHOzNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF6LkSwOFMh|ryP M376cXNCVkeHUh?=
SK-MEL-3 M3nQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF6Lk[2O|kh|ryP NFntcoNUSU6JRWK=
LK-2 M{PaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DHZmlEPTB;MUiuO|czOyEQvF2= MWnTRW5ITVJ?
PANC-08-13 NFvEbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzHSFVJUUN3ME2xPE44QDh7IN88US=> NV;2SmZmW0GQR1XS
NCI-H460 NU\aWXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjwXXpKSzVyPUG4Mlg1PjZizszN Mn3PV2FPT0WU
COLO-684 M3\6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\Qb5BJUUN3ME2xPE46QTV4IN88US=> NHOyfWJUSU6JRWK=
RPMI-2650 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfvd4txUUN3ME2xPU4xOTJizszN MlPIV2FPT0WU
NY MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF7LkG1Olch|ryP MUDTRW5ITVJ?
NB7 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX0dVROUUN3ME2xPU4yPzV|IN88US=> MW\TRW5ITVJ?
NCI-H358 NEPi[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor0TWM2OD1zOT6yOlc{KM7:TR?= M2L1enNCVkeHUh?=
MC116 NUTxdmZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILkbnlKSzVyPUG5MlU{OzFizszN NUHNd44xW0GQR1XS
MS-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTF7Lk[xNFMh|ryP NFPQOHdUSU6JRWK=
NCI-H82 NWTqcYExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e3XWlEPTB;MUmuOlg4QCEQvF2= NEeyd4hUSU6JRWK=
OCI-AML2 NXLZRpJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF7LkewN|Ih|ryP M4WwNHNCVkeHUh?=
LS-123 NH6z[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf2TWM2OD1{MD6wNVk1KM7:TR?= MlX2V2FPT0WU
PC-14 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XvZmlEPTB;MkCuNVg{PCEQvF2= NX;2[Yk6W0GQR1XS
NCI-H1703 M4H6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT5WpdKSzVyPUKwMlgyPzNizszN MXrTRW5ITVJ?
Calu-6 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrPc4lVUUN3ME2yNU4yODB3IN88US=> M{DobHNCVkeHUh?=
no-11 M3rSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvNTWM2OD1{MT6xOlAzKM7:TR?= MnHMV2FPT0WU
NCI-H727 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGxTWM2OD1{MT6zOFk{KM7:TR?= MYHTRW5ITVJ?
DSH1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfKXXNEUUN3ME2yNU4{QDd7IN88US=> MW\TRW5ITVJ?
KYSE-140 Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrTR2dKSzVyPUKxMlczPzFizszN MV3TRW5ITVJ?
RH-1 NFfnVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDuTGVKSzVyPUKxMlg5OyEQvF2= NIX3d5JUSU6JRWK=
HAL-01 NHm2S2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jBfWlEPTB;MkKuNFQyQCEQvF2= NELWdnpUSU6JRWK=
RXF393 NIH3SItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nSemlEPTB;MkKuNlc5QSEQvF2= NF7OephUSU6JRWK=
LS-411N MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDhT41UUUN3ME2yNk4zQDZ7IN88US=> NUHud3BKW0GQR1XS
no-10 Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\LcWlEPTB;MkKuOVAxPCEQvF2= M1T6[HNCVkeHUh?=
MKN7 NEi4O|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnD[5VKUUN3ME2yNk43QDdizszN NWOzSGpIW0GQR1XS
AU565 M2HNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HJVmlEPTB;MkKuO|Q4QCEQvF2= MVzTRW5ITVJ?
NUGC-3 M2f5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS0TWM2OD1{Mz6xNVk6KM7:TR?= MVrTRW5ITVJ?
EW-16 NW[5fldTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojkTWM2OD1{ND6wPVI3KM7:TR?= MV3TRW5ITVJ?
HCC70 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLzTFJKSzVyPUK0MlE{OjNizszN NE\jUnhUSU6JRWK=
RPMI-8226 NELqdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\BWZNEUUN3ME2yOE4{OTV3IN88US=> NUnBOIRwW0GQR1XS
CFPAC-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn5[pVKSzVyPUK0MlYzPzJizszN NXXtfmhLW0GQR1XS
DoTc2-4510 NWX5RnVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGxenVPUUN3ME2yOE44PTd3IN88US=> MW\TRW5ITVJ?
KNS-62 MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT3UYxwUUN3ME2yOU4xOThizszN NHqzcJNUSU6JRWK=
SK-N-DZ MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PFSGlEPTB;MkWuNFkxPCEQvF2= MXPTRW5ITVJ?
CAL-85-1 M4\NT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi0UIJzUUN3ME2yOU4yPTR2IN88US=> NUDKXnZ{W0GQR1XS
JVM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ3LkKxNlIh|ryP NYXBPGt3W0GQR1XS
NCI-H2347 NFz3UmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJ3LkSyOFkh|ryP NFjaZnBUSU6JRWK=
P30-OHK NV:xO3p4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJ3Lk[zNVgh|ryP NFrqS|ZUSU6JRWK=
SK-N-FI MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{naTmlEPTB;Mk[uNVE3OiEQvF2= NUDVSVJnW0GQR1XS
CAMA-1 NF6xXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJ4LkS4O|Yh|ryP NXPvTWNxW0GQR1XS
MHH-NB-11 NWHGOoc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXEbIp2UUN3ME2yOk42QDVzIN88US=> M33DXnNCVkeHUh?=
IST-MEL1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjkdIhKSzVyPUK2MlcyPzdizszN NUP0dlRHW0GQR1XS
KARPAS-299 NVvLTIszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ5LkS3NFEh|ryP M1L6ZnNCVkeHUh?=
TE-11 MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\2TmlEPTB;MkeuO|M1OiEQvF2= Ml;XV2FPT0WU
769-P NEXidIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ6LkS1N|Mh|ryP NWrkUHNJW0GQR1XS
CAL-72 MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zobmlEPTB;MkiuOVU3OSEQvF2= MlvzV2FPT0WU
NCI-H2342 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT1cVBSUUN3ME2yPU4{QDB|IN88US=> NHrTRlJUSU6JRWK=
NCI-H1651 NVW5dGhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn34TWM2OD1{OT64OVA{KM7:TR?= Ml;3V2FPT0WU
OE33 NYn4cWhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNyLkGzOFIh|ryP MkjVV2FPT0WU
HuP-T4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfTWG5NUUN3ME2zNU41QDN5IN88US=> MY\TRW5ITVJ?
U-118-MG NIKxbnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4r1VGlEPTB;M{KuOVQ1OSEQvF2= MWjTRW5ITVJ?
SN12C M4nsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e2d2lEPTB;M{KuPFgyPSEQvF2= MYXTRW5ITVJ?
TE-5 M4q1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUiyOJZUUUN3ME2zN{4yOzZ6IN88US=> NUjNNFJRW0GQR1XS
KM-H2 NH;0SmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nYTmlEPTB;M{OuNVY6QSEQvF2= MnHVV2FPT0WU
OVCAR-3 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XSfGlEPTB;M{OuOFEzPyEQvF2= NUizXW5PW0GQR1XS
NCI-H1304 M4G2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nHVmlEPTB;M{OuOlA{PiEQvF2= NVLwemFVW0GQR1XS
LU-135 M2XD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DnT2lEPTB;M{OuO|A5PiEQvF2= MVTTRW5ITVJ?
S-117 NWrJRldHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN|LkeyPFYh|ryP M1S1fnNCVkeHUh?=
NCI-H1755 NUmxfmpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXJTWM2OD1|Mz64NVEh|ryP MlHOV2FPT0WU
Mo-T NGPETZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojFTWM2OD1|Mz64OVk{KM7:TR?= NHjMc49USU6JRWK=
SK-OV-3 NWW4e2Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN|Lki4OVQh|ryP MmnrV2FPT0WU
RCC10RGB M1v4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLxd2VLUUN3ME2zN{46PDN|IN88US=> NILyN4hUSU6JRWK=
COLO-680N M4nvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTN2LkGzPVch|ryP NW\JU5huW0GQR1XS
KURAMOCHI NEPZXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HhbmlEPTB;M{SuOlQzPSEQvF2= M{DnPXNCVkeHUh?=
NCI-H661 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DIcWlEPTB;M{SuPFQ1QCEQvF2= MoLiV2FPT0WU
YAPC NIH4eY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPKVXNsUUN3ME2zOU46PTN|IN88US=> NUnKW5JlW0GQR1XS
NCI-H526 M2P4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHHN5dKSzVyPUO3MlI4PzJizszN NGrRb25USU6JRWK=
A498 M{T5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPJTWM2OD1|OD6wPVU1KM7:TR?= MVLTRW5ITVJ?
VMRC-RCZ NETpVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTN7LkCwOVQh|ryP NUC1UGtPW0GQR1XS
HCT-116 NI\kS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PGNmlEPTB;M{muNFU5KM7:TR?= MVnTRW5ITVJ?
COLO-320-HSR NGXYcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHaeppKSzVyPUSwMlA1OSEQvF2= NVX2XYNZW0GQR1XS
OAW-42 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LlbWlEPTB;NECuNFU1OiEQvF2= NGizR4FUSU6JRWK=
SK-MEL-1 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTRyLkK5Nlch|ryP NGfuOG5USU6JRWK=
IST-MES1 M1PlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzz[3NTUUN3ME20NE44PjV|IN88US=> MXLTRW5ITVJ?
CP50-MEL-B Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XTVWlEPTB;NEGuNFc6PyEQvF2= M1nXfnNCVkeHUh?=
RMG-I NEjscVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTR{LkS5NlEh|ryP M4X0WnNCVkeHUh?=
D-336MG M2C2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DKe2lEPTB;NEOuNVE2OiEQvF2= M{jkOnNCVkeHUh?=
SHP-77 NGLYdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofzTWM2OD12Mz6xPFI5KM7:TR?= NUHnW4gyW0GQR1XS
SW872 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnyTWM2OD12Mz6yNVI{KM7:TR?= NYHuNGljW0GQR1XS
DBTRG-05MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTR2Lk[5PVYh|ryP MYPTRW5ITVJ?
COLO-678 M1y2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTR3LkewN|Ih|ryP MlPIV2FPT0WU
EGI-1 M4\5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rZNmlEPTB;NEeuNVg{OyEQvF2= M1TwO3NCVkeHUh?=
KYSE-70 NI\vO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTTcIExUUN3ME20O{44OjJ{IN88US=> M3;6VnNCVkeHUh?=
BALL-1 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\sT2lEPTB;NEeuPFI2PCEQvF2= MYTTRW5ITVJ?
MDA-MB-361 NYjOSWxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3NTWM2OD12OD6wOFYh|ryP NWLvcWNuW0GQR1XS
NCI-H1838 Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzDTWM2OD12OD6zOFU5KM7:TR?= NXHvSllrW0GQR1XS
NCI-H1573 NHXhe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnYOIlWUUN3ME20PE43Pzh3IN88US=> MULTRW5ITVJ?
HCC1395 MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXTSW9JUUN3ME20PE46QTJizszN MV7TRW5ITVJ?
NCI-H2291 M2O0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPyeYNKSzVyPUS5MlU6QDhizszN NVLRSGNQW0GQR1XS
RH-18 NYrESJNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYG2TIdIUUN3ME21NE4xQDh2IN88US=> M1[0OnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

17040210 28415756 25395420
Immunofluorescence
PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

25002506
Growth inhibition assay
Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

28415756

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A
Smiles CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID