BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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Cited by 7 Publications

4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

    (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfnTWM2OD1yLkCzOVgh|ryP M4j2[XNCVkeHUh?=
H9 M4fmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PNTWlEPTB;MD6wOlAyQSEQvF2= MYTTRW5ITVJ?
KARPAS-45 NXHCWHQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml:zTWM2OD1yLkG2OVI2KM7:TR?= NXPCVVJMW0GQR1XS
NCI-H720 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;UTWM2OD1yLkG3NVk1KM7:TR?= MUHTRW5ITVJ?
CTV-1 MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLlTWM2OD1yLkS3PFczKM7:TR?= NFza[nJUSU6JRWK=
DU-4475 Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfJTnU1UUN3ME2wMlUxPDF5IN88US=> MmCzV2FPT0WU
A172 NXvJRZdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwNUG3NFUh|ryP MWLTRW5ITVJ?
EW-18 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTrWFlKSzVyPUCuOlIzOTFizszN M1vSb3NCVkeHUh?=
KU812 M3HtOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zSOGlEPTB;MD62NlYzOyEQvF2= NF\qOY1USU6JRWK=
KP-N-YS MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\STWM2OD1yLk[4NlI{KM7:TR?= NEXFNotUSU6JRWK=
SBC-1 M4LQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorzTWM2OD1yLk[5OVI1KM7:TR?= M2n2VXNCVkeHUh?=
ECC10 NVW4WlJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwN{CwPVQh|ryP M{DyZ3NCVkeHUh?=
GAMG NUnOVVNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXVTHhKSzVyPUCuO|Q4OTdizszN MWnTRW5ITVJ?
NCI-H209 Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPHeYdxUUN3ME2wMlc3QDJizszN MX;TRW5ITVJ?
MC-IXC NFP1[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS0[YVKSzVyPUCuO|k2QDlizszN Ml7PV2FPT0WU
HSC-3 NIPDcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KxfGlEPTB;MD64NVc3QSEQvF2= NGfBfYdUSU6JRWK=
IST-SL1 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1raSWlEPTB;MD64OFU4PCEQvF2= M3HUOHNCVkeHUh?=
LU-139 NIXCbZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHzb5BYUUN3ME2wMlg1QTV6IN88US=> NF;Gb4RUSU6JRWK=
ML-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjuXYdDUUN3ME2wMlg2PTd3IN88US=> MWPTRW5ITVJ?
CAL-62 M2KzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwOEixOVIh|ryP M2nNNXNCVkeHUh?=
HL-60 NX;tO|Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTxPZNKSzVyPUCuPFg{PjJizszN M1nqXHNCVkeHUh?=
KY821 M4POOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf5eJRSUUN3ME2wMlg5QDF{IN88US=> M1nRVnNCVkeHUh?=
ES7 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXLNFVKSzVyPUCuPVE3ODdizszN M3PyOnNCVkeHUh?=
MV-4-11 NGWxTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\OXGlEPTB;MD65O|g6PyEQvF2= MkXYV2FPT0WU
Daoy NHnpc|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\ZPFJIUUN3ME2wMlk5PzZ5IN88US=> NFuyZVdUSU6JRWK=
EoL-1-cell NF[3bmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HFPWlEPTB;MT6wNVg4QCEQvF2= NFXibGtUSU6JRWK=
TGW MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH2e3RYUUN3ME2xMlA2OTJ2IN88US=> Mmj4V2FPT0WU
LAMA-84 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfBVHM4UUN3ME2xMlEzPzl2IN88US=> MmXoV2FPT0WU
KOSC-2 NYnZfZZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TheWlEPTB;MT6xN|M5PSEQvF2= M4D1fHNCVkeHUh?=
A549 NXP3[XNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlf4TWM2OD1zLkOwPVU2KM7:TR?= NVrKOYw4W0GQR1XS
CTB-1 NVHjTYZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjBW3VKSzVyPUGuOFQ3PzlizszN Ml\qV2FPT0WU
NCI-H292 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:zR2VKSzVyPUGuOFYxPjlizszN NVm5TJI{W0GQR1XS
LoVo M4Dsb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorFTWM2OD1zLkS2O|U2KM7:TR?= MXTTRW5ITVJ?
BFTC-905 NHL0W2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojUTWM2OD1zLkW2N|MzKM7:TR?= NX3oU4tmW0GQR1XS
BE-13 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjKendKSzVyPUGuOVg4ODlizszN Ml3mV2FPT0WU
KE-37 NH63PWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITFdGhKSzVyPUGuOVk1PzhizszN NVfHdJRJW0GQR1XS
HN NWXWWIlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3GZ2lKSzVyPUGuOlE{PjhizszN MkjWV2FPT0WU
A3-KAW NUfrXoxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrSbpg2UUN3ME2xMlYzQDN2IN88US=> MWDTRW5ITVJ?
NEC8 NFfXelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y1UWlEPTB;MT63NFEyPSEQvF2= MYjTRW5ITVJ?
Ramos-2G6-4C10 NGXm[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTFwN{C0OFQh|ryP NYT1V5o6W0GQR1XS
NB10 M2HzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXBTWM2OD1zLke3OlMh|ryP Ml7YV2FPT0WU
NBsusSR M1rXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jF[2lEPTB;MT64Nlk3OSEQvF2= MnHvV2FPT0WU
ES4 M3HJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHRc2JCUUN3ME2xMlg2OTR|IN88US=> NWnUR4ZLW0GQR1XS
ES8 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETVb|hKSzVyPUGuPFc4OjRizszN MnnTV2FPT0WU
CHL-1 NWHqfJZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrvRotiUUN3ME2xMlk2Pzl{IN88US=> NIfSUWNUSU6JRWK=
NCI-H2029 NVOzeJNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIToXYRKSzVyPUGuPVczPDFizszN MWnTRW5ITVJ?
YKG-1 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD4TWM2OD1zLkm4OFMzKM7:TR?= M3HoNnNCVkeHUh?=
BV-173 M3HRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDKTWM2OD1zLkm4OlY3KM7:TR?= NGn5NZFUSU6JRWK=
697 MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJwMEKyNlgh|ryP MWTTRW5ITVJ?
SK-NEP-1 M2HwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD0dnkxUUN3ME2yMlA1PCEQvF2= MVHTRW5ITVJ?
LOXIMVI M2Hv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3nVG1KSzVyPUKuNFQ1OzRizszN M1zMfnNCVkeHUh?=
QIMR-WIL NF;yW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVraOYU2UUN3ME2yMlA4QDR7IN88US=> MYjTRW5ITVJ?
DU-145 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJwMUGwOVYh|ryP NHr4eVdUSU6JRWK=
NB14 M{jmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXNZ49KSzVyPUKuNVE{OjFizszN NF\1[ndUSU6JRWK=
G-361 NYnQVYRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFu5bm9KSzVyPUKuNVIzOSEQvF2= MXjTRW5ITVJ?
BPH-1 NFy5W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonFTWM2OD1{LkGyPVU4KM7:TR?= M{\rRXNCVkeHUh?=
KYSE-150 NF7MTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjTXWFKSzVyPUKuNVUzOzRizszN NEXpOmxUSU6JRWK=
HMV-II MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX3dGpCUUN3ME2yMlE3PjN|IN88US=> MVXTRW5ITVJ?
TE-9 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwMUezO|Yh|ryP NGHhTW1USU6JRWK=
8-MG-BA MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHftco9KSzVyPUKuNlM1PjFizszN M{T0[3NCVkeHUh?=
ES5 MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;YTWM2OD1{LkKzOlM{KM7:TR?= MXfTRW5ITVJ?
D-283MED MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLFTWM2OD1{LkKzOlk2KM7:TR?= MXXTRW5ITVJ?
SK-N-AS M{ntemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TacWlEPTB;Mj6yPVA2QSEQvF2= MlrnV2FPT0WU
SW1710 NXLEb4hPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTJwM{C2OlEh|ryP NXzEXphqW0GQR1XS
GCT M1jQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknQTWM2OD1{LkOxN|U5KM7:TR?= NVL1[okyW0GQR1XS
AGS MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG1d41KSzVyPUKuN|Q1ODRizszN MmDCV2FPT0WU
HuO9 NG\SW|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[yVXNKSzVyPUKuN|Y5OjRizszN NIWzZYpUSU6JRWK=
MN-60 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJwNES4PFMh|ryP NVzHXWZwW0GQR1XS
NB6 NXzJblQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHpZodKSzVyPUKuOFU4PzlizszN MXfTRW5ITVJ?
NCI-H1395 NIL4eXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHKT3dvUUN3ME2yMlQ4OTJzIN88US=> NUHpdoFVW0GQR1XS
H4 Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTDTWM2OD1{LkS4N|k{KM7:TR?= NITXS|lUSU6JRWK=
HT-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPh[o9QUUN3ME2yMlUyODJ2IN88US=> MlLZV2FPT0WU
P12-ICHIKAWA NGOxVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz2TWM2OD1{LkWyOVU6KM7:TR?= NUjmXoNxW0GQR1XS
COLO-800 NGraXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJwNUSxOlYh|ryP NIfyW3JUSU6JRWK=
DB MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJwNUWwNVMh|ryP MXXTRW5ITVJ?
LCLC-97TM1 NUW5XmM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mle3TWM2OD1{Lk[wNFI5KM7:TR?= NYj5fWhYW0GQR1XS
Ca9-22 M{TwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorCTWM2OD1{Lk[1PVM{KM7:TR?= NILmOZBUSU6JRWK=
Becker NY\WRVJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwNk[wO|gh|ryP MYTTRW5ITVJ?
ACN M1\ldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLBbVJCUUN3ME2yMlY3PzlizszN MWrTRW5ITVJ?
SJSA-1 M3S2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTydlBKSzVyPUKuOlY5PyEQvF2= M1y1THNCVkeHUh?=
NCI-H1048 NXLEeW04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD4TWM2OD1{Lk[4N|IyKM7:TR?= MWLTRW5ITVJ?
HEL MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJwN{CyOVQh|ryP NFHE[JdUSU6JRWK=
NCI-H69 NHTofWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXpTWM2OD1{LkexOlAyKM7:TR?= M4PpdnNCVkeHUh?=
639-V M{XlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIiyXI9KSzVyPUKuO|E4ODNizszN NWTuemUxW0GQR1XS
U251 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\2TWM2OD1{LkezNFMzKM7:TR?= NWjKO5h2W0GQR1XS
NCI-H1792 NIK4SGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS2TWM2OD1{LkezO|M5KM7:TR?= NX;Yc3VPW0GQR1XS
EW-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHsWHZiUUN3ME2yMlc2OzJ6IN88US=> M2npTXNCVkeHUh?=
ME-180 NULnXY4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHzUJh[UUN3ME2yMlc4PzN4IN88US=> NHzzUpFUSU6JRWK=
HH NE\oc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwOECwNFEh|ryP MVfTRW5ITVJ?
SW954 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLwTWM2OD1{Lki1PFMh|ryP M4THcnNCVkeHUh?=
SF268 M3XjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3mwN2lEPTB;Mj64O|IzPSEQvF2= NXfZTWZ4W0GQR1XS
D-566MG NFXRW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HLfmlEPTB;Mj65NVI6PSEQvF2= MkC4V2FPT0WU
EM-2 NFy4eWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zl[mlEPTB;Mj65NlE6OyEQvF2= M3fve3NCVkeHUh?=
NCI-H1299 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTubGRUUUN3ME2yMlk{PzN4IN88US=> NW\2d3U6W0GQR1XS
PSN1 NX;LVlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLjd5c3UUN3ME2zMlA2Pzh4IN88US=> M4rs[XNCVkeHUh?=
JVM-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTNwME[3OVYh|ryP Mm\sV2FPT0WU
D-502MG NWjYdYp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzJTplKSzVyPUOuNFcxOTlizszN MX3TRW5ITVJ?
SCC-4 M{PaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLLRVNKSzVyPUOuNFkzPzZizszN M2PUUnNCVkeHUh?=
GMS-10 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTNwMEmzPFgh|ryP NILGO4VUSU6JRWK=
A427 M2rwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLCZ|VTUUN3ME2zMlExQDd|IN88US=> MmrQV2FPT0WU
NH-12 NXHYPVE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTNwMUG0OVYh|ryP M3f0TnNCVkeHUh?=
KM12 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLJ[ZpKSzVyPUOuNVIzPzNizszN NFPTXmRUSU6JRWK=
GI-1 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTNwMUWyOVUh|ryP NYLDUFN3W0GQR1XS
TE-8 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXuTWM2OD1|LkG5NlMyKM7:TR?= M2nyOnNCVkeHUh?=
MKN1 Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrrTWM2OD1|LkKwPFc2KM7:TR?= NIjJ[|dUSU6JRWK=
NCI-H810 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHmTWM2OD1|LkKyNVU2KM7:TR?= NWO0XGdyW0GQR1XS
GOTO NXTab3E3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTNwMkiwNFQh|ryP MoT2V2FPT0WU
T98G MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom3TWM2OD1|LkK4NlE3KM7:TR?= MWrTRW5ITVJ?
HD-MY-Z NH[1VY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfHXYtKSzVyPUOuN|Y2PDJizszN MYXTRW5ITVJ?
SNU-C2B NF23TVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rjVWlEPTB;Mz6zPVA6PyEQvF2= MoLwV2FPT0WU
MOLT-4 NWHZd3Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLycpVKSzVyPUOuN|kxQThizszN MoLvV2FPT0WU
RPMI-7951 MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTNwM{m3N{DPxE1? NHHzSYJUSU6JRWK=
EW-11 MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL0S2lKSzVyPUOuOFEzOjRizszN Mnf3V2FPT0WU
RD Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPydGMxUUN3ME2zMlQ{OTN{IN88US=> M3v5SnNCVkeHUh?=
SW48 NH[5Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rvXWlEPTB;Mz60N|M2QCEQvF2= M2fDW3NCVkeHUh?=
BB65-RCC NFzuSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nKTGlEPTB;Mz60OVM6PiEQvF2= NFjGfIRUSU6JRWK=
Ca-Ski NGXUTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjleWhKSzVyPUOuOFc2OTRizszN NEHyOphUSU6JRWK=
CHP-134 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHITWM2OD1|LkS4O|U5KM7:TR?= NV7Xbm1HW0GQR1XS
CAL-33 NELp[|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTNwNUOzOlIh|ryP NIPIbGFUSU6JRWK=
TYK-nu M3PZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO1NJJKSzVyPUOuOVM3PzZizszN M2TQPXNCVkeHUh?=
LB831-BLC NFW1d5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjnOIlFUUN3ME2zMlU1ODF4IN88US=> MoXRV2FPT0WU
KU-19-19 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNwNkCzNFQh|ryP M3fXd3NCVkeHUh?=
KG-1 MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXOTWM2OD1|Lk[xNVA3KM7:TR?= NYPxcHV4W0GQR1XS
COLO-829 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH71VHVKSzVyPUOuOlY3OThizszN MkT1V2FPT0WU
HUTU-80 M3TkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\3WoNKSzVyPUOuOlY3OjFizszN Ml7VV2FPT0WU
NCI-H446 M{fCfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH5VnhKSzVyPUOuOlg{PCEQvF2= NHz6eoNUSU6JRWK=
LB2241-RCC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nxRWlEPTB;Mz62PFYzPSEQvF2= MkHMV2FPT0WU
JEG-3 NWLiRnZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTNwNkmxPUDPxE1? NUTxcZlZW0GQR1XS
LNCaP-Clone-FGC NV;aNZR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDXR|RKSzVyPUOuO|AxPDFizszN MYrTRW5ITVJ?
M059J NF:zN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LRSWlEPTB;Mz63NVQ3QCEQvF2= NFO0cmRUSU6JRWK=
SK-MES-1 NX73Um44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTNwN{OwN{DPxE1? NXu4emZ1W0GQR1XS
GT3TKB Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LVSGlEPTB;Mz63OVYxPCEQvF2= M4PRPXNCVkeHUh?=
DOK MknxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHDNHdvUUN3ME2zMlc3PTJ4IN88US=> NYrWXoJYW0GQR1XS
HO-1-N-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNwN{m4NFEh|ryP MWjTRW5ITVJ?
MZ1-PC NVGwR2ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofoTWM2OD1|LkiyPFg{KM7:TR?= MXPTRW5ITVJ?
8305C MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXGxSo9[UUN3ME2zMlg5QTR|IN88US=> M3jmPXNCVkeHUh?=
CGTH-W-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPzeVRJUUN3ME2zMlk{PTB2IN88US=> MnrLV2FPT0WU
LU-134-A MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvzTWM2OD1|Lkm1OFIzKM7:TR?= MmPwV2FPT0WU
C32 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXTT2JKSzVyPUOuPVY2QDFizszN NVvnfmNOW0GQR1XS
MOLT-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnpT2VWUUN3ME2zMlk3QDV4IN88US=> MmDZV2FPT0WU
A375 NGjJVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXmyXIEyUUN3ME20MlA2OTZ{IN88US=> NYP2RpBJW0GQR1XS
CAL-12T NFK5WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH73ZlBKSzVyPUSuNFU4QTVizszN MkjUV2FPT0WU
IGR-1 NXX5bGcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPN[JU3UUN3ME20MlExOjd2IN88US=> NUjKeYJqW0GQR1XS
LB1047-RCC M1vyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPwbnlKSzVyPUSuNVA1PDFizszN M4HidnNCVkeHUh?=
BHT-101 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRwMUC2PFMh|ryP M1vWOXNCVkeHUh?=
A431 NV\Ce2FRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHlN4VUUUN3ME20MlE1ODhzIN88US=> Mof1V2FPT0WU
EPLC-272H M1vYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjZTWM2OD12LkG3OVk3KM7:TR?= MkGxV2FPT0WU
HT-1376 NF\wd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjhSJNKSzVyPUSuNlMxPTlizszN M4fBUHNCVkeHUh?=
HCC1954 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC5VWR3UUN3ME20MlI2PzR4IN88US=> MYTTRW5ITVJ?
KYSE-510 M3e3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fJZ2lEPTB;ND6yOlA6KM7:TR?= M33MdXNCVkeHUh?=
PANC-03-27 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonHTWM2OD12LkOwNFg{KM7:TR?= M33ibHNCVkeHUh?=
MDA-MB-157 M{m1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTRwM{C2OVYh|ryP NH;aOotUSU6JRWK=
HOP-62 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjYfplKSzVyPUSuN|A5PTZizszN MV\TRW5ITVJ?
ETK-1 M4T4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;2bmlEPTB;ND6zOlIxOyEQvF2= M{XzPXNCVkeHUh?=
MIA-PaCa-2 NHWwSphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTRwM{[yNlch|ryP M1rBc3NCVkeHUh?=
MHH-PREB-1 M3u1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXLTWM2OD12LkO5O|c{KM7:TR?= M1r4b3NCVkeHUh?=
LXF-289 MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTRwNECyNFIh|ryP MkXZV2FPT0WU
ATN-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTtTWM2OD12LkSyN|QyKM7:TR?= MV\TRW5ITVJ?
8505C MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTRwNEW4NlUh|ryP NYfkOnlGW0GQR1XS
HOS NXfuW24yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\OdGlEPTB;ND60OlQ2OyEQvF2= MlPXV2FPT0WU
U-266 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XyXmlEPTB;ND62NVA{OiEQvF2= MlPCV2FPT0WU
5637 NUDHZXNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TPPWlEPTB;ND62NVQ1PCEQvF2= NIjN[mZUSU6JRWK=
GCIY NGC3VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTRwN{GwNVUh|ryP NV3HXoVuW0GQR1XS
MDA-MB-231 NID4[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7iTWM2OD12LkeyNVE2KM7:TR?= MVrTRW5ITVJ?
RKO MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfVTWM2OD12LkeyPFE4KM7:TR?= NYS2WI5EW0GQR1XS
COR-L23 M1ewfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrPO2pKSzVyPUSuO|QzPTZizszN MkmzV2FPT0WU
DJM-1 NXH2XXJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XJN2lEPTB;ND63PVczQSEQvF2= NEi4TI1USU6JRWK=
D-423MG NVi5dlRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTRwOEC4NFMh|ryP NE\3OZJUSU6JRWK=
DMS-114 NWC1dlBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;wTWM2OD12LkixN|g3KM7:TR?= NFrzR4ZUSU6JRWK=
MHH-ES-1 M1PuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj5d45JUUN3ME20MlgzPTB2IN88US=> Mn;1V2FPT0WU
CAL-51 Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NISy[5dKSzVyPUSuPFY5PDNizszN NHu2[|BUSU6JRWK=
SW626 NVexeYlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfzRpRVUUN3ME20Mlg6Pjl5IN88US=> MnrTV2FPT0WU
COLO-824 MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TjemlEPTB;ND65NFQxQCEQvF2= NI\TPXZUSU6JRWK=
NCI-H1437 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTRwOUK5N{DPxE1? MXzTRW5ITVJ?
CAL-39 MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTRwOUO5PFgh|ryP NXvxRVJ3W0GQR1XS
PC-3 NXfLd4lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXoS5B{UUN3ME20Mlk1PjR6IN88US=> MlzDV2FPT0WU
A101D MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTRwOU[4OlUh|ryP M2C2cXNCVkeHUh?=
ES1 M3fw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\vSYxKSzVyPUWuNFAyOyEQvF2= NWX1b2VWW0GQR1XS
TE-1 NWTZZlNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzWXmdKSzVyPUWuNFM3PjZizszN Mke0V2FPT0WU
KP-N-YN NYf6WGk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDDZoV5UUN3ME21MlA2PjdizszN M{faNHNCVkeHUh?=
EFO-27 Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fUU2lEPTB;NT6wOlMzQSEQvF2= M2nldHNCVkeHUh?=
BT-549 Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrzXINKSzVyPUWuNFc4OzZizszN NFLVW5pUSU6JRWK=
HLE M4juVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXZSW17UUN3ME21MlEyPzN2IN88US=> M4LBeXNCVkeHUh?=
SW982 NG[1[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLw[XlKSzVyPUWuNVM{PzRizszN NXzFWnh[W0GQR1XS
SCC-25 M{[xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fke2lEPTB;NT6xPVA1PiEQvF2= Mn;FV2FPT0WU
SK-MEL-28 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe1UpdRUUN3ME21MlIxOzF|IN88US=> MVTTRW5ITVJ?
CaR-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTVwMkC3NlYh|ryP NEDRbYhUSU6JRWK=
MLMA MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfFTWM2OD13LkKzOFM3KM7:TR?= NH3FWZlUSU6JRWK=
VM-CUB-1 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTVwMkO0N|kh|ryP Mmq4V2FPT0WU
KNS-42 M2LvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\weGlEPTB;NT6yOlE3KM7:TR?= MXLTRW5ITVJ?
TK10 NFryNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP3TWM2OD13LkO2NFg3KM7:TR?= M37RSHNCVkeHUh?=
MEG-01 NXzw[2hZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTVwM{[yO|Qh|ryP NYn2eWZuW0GQR1XS
DEL M3L6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i3NWlEPTB;NT6zPVAzOyEQvF2= MmjiV2FPT0WU
SJRH30 NUXnNZJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7UTWM2OD13LkO5NlE{KM7:TR?= MmjIV2FPT0WU
SK-PN-DW NVLtNVNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO2TWM2OD13LkSzOVg6KM7:TR?= MlzwV2FPT0WU
TE-10 M3vHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e2NWlEPTB;NT60OFg6OyEQvF2= M2jZ[XNCVkeHUh?=
KNS-81-FD NG[4Tm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml6xTWM2OD13LkWwNFkzKM7:TR?= NFjFdWlUSU6JRWK=
BHY MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjiXHJzUUN3ME21MlUyODdizszN NYDlNHdpW0GQR1XS
KYSE-270 MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DtbGlEPTB;NT61N|U{PiEQvF2= MlHSV2FPT0WU
NCI-H650 NYn6WpNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTVwNUexNVQh|ryP M{f4cnNCVkeHUh?=
L-363 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHIW45KSzVyPUWuOlk1PzZizszN M4OxXnNCVkeHUh?=
TCCSUP M2O4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XodWlEPTB;NT63NVc4QCEQvF2= NVzFd4lSW0GQR1XS
SCH MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjCTWM2OD13Lke0O|Y4KM7:TR?= MUTTRW5ITVJ?
HTC-C3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmmwTWM2OD13Lke3OlQ1KM7:TR?= M2\4S3NCVkeHUh?=
J-RT3-T3-5 M4HKcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7YTWM2OD13LkiwO|k1KM7:TR?= MXHTRW5ITVJ?
Hs-578-T MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\HeGlEPTB;NT64N|YxPyEQvF2= MVfTRW5ITVJ?
M14 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PGZ2lEPTB;NT64OlczPiEQvF2= MVHTRW5ITVJ?
HT-144 M1rv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TKSGlEPTB;NT64Olg{OiEQvF2= M1zCNnNCVkeHUh?=
CAL-54 NVvVTmp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3lXIJtUUN3ME21Mlk{OzF2IN88US=> M{HqOHNCVkeHUh?=
T47D NGXRN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T0NWlEPTB;NT65OlEzKM7:TR?= M3XYSHNCVkeHUh?=
GB-1 NYTqPG1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP5SpFPUUN3ME22MlAzODZ6IN88US=> MWDTRW5ITVJ?
HSC-2 NXj1PHo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvMVoJxUUN3ME22MlEzOzV|IN88US=> NEPTeIVUSU6JRWK=
SiHa NFHoUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\jNmlEPTB;Nj6xOFA6PyEQvF2= MnH6V2FPT0WU
OMC-1 NHTpdpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XyN2lEPTB;Nj6zOVQ1OSEQvF2= NXXZeJR2W0GQR1XS
HGC-27 NXzhSG5jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfUTWM2OD14LkO1O|g3KM7:TR?= MVzTRW5ITVJ?
FTC-133 MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vxTmlEPTB;Nj60OlU2OSEQvF2= MULTRW5ITVJ?
KS-1 NYP6dopUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTZwNUKxOFch|ryP MXLTRW5ITVJ?
HT-1080 NH7uW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vMdmlEPTB;Nj61OFA1OiEQvF2= M4PzNXNCVkeHUh?=
SKG-IIIa MlPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LC[mlEPTB;Nj61OlI3OyEQvF2= MlO3V2FPT0WU
OCUB-M NVrnU2k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITpVlRKSzVyPU[uOlA4PyEQvF2= M4K3WnNCVkeHUh?=
MDA-MB-175-VII MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEL2elBKSzVyPU[uOlIxQSEQvF2= NGLFN5dUSU6JRWK=
BB30-HNC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTZwNke0OFQh|ryP M2jFb3NCVkeHUh?=
D-542MG NWf2dJRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TFT2lEPTB;Nj63N|A6KM7:TR?= NYfzXYNZW0GQR1XS
NCI-H2405 MoH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm0TWM2OD14Lke0PFU2KM7:TR?= M{nvdnNCVkeHUh?=
SW1573 MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjZTWM2OD14Lke4N|E6KM7:TR?= NEK5[VdUSU6JRWK=
NCI-SNU-1 NX7ncIF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPmZnJKSzVyPU[uO|kxOjJizszN NWfmW211W0GQR1XS
RT-112 NYS3fpdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HSPGlEPTB;Nj63PVQ3OyEQvF2= NH65TWhUSU6JRWK=
COR-L88 NHe3[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTLN2xKSzVyPU[uO|k4QTFizszN MkHvV2FPT0WU
SCC-9 M4TSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTZwOEK1OUDPxE1? MYPTRW5ITVJ?
U-87-MG M4XoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXFc29MUUN3ME22Mlg{QDJ4IN88US=> NWfHd2pRW0GQR1XS
Detroit562 M2X2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7Be|ZuUUN3ME22Mlg2QTlzIN88US=> MWnTRW5ITVJ?
LC-2-ad MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTZwOE[yPVIh|ryP Mn2yV2FPT0WU
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LU-65 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XyS2lEPTB;MUiuOFA1OyEQvF2= MX;TRW5ITVJ?
SK-MEL-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn2TWM2OD1zOD62Olc6KM7:TR?= MXHTRW5ITVJ?
LK-2 NV7GUnNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFSxR2tKSzVyPUG4Mlc4OjNizszN MkfMV2FPT0WU
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COLO-684 M1PEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37F[mlEPTB;MUiuPVk2PiEQvF2= NETF[pVUSU6JRWK=
RPMI-2650 NUjvOGJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3DWXV6UUN3ME2xPU4xOTJizszN MnnwV2FPT0WU
NY NVzvNW05T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mke3TWM2OD1zOT6xOVY4KM7:TR?= NEixV5FUSU6JRWK=
NB7 NVPJd|NKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnNT41qUUN3ME2xPU4yPzV|IN88US=> M2\FWHNCVkeHUh?=
NCI-H358 NIC3ZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nBWGlEPTB;MUmuNlY4OyEQvF2= MV3TRW5ITVJ?
MC116 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHkfWFRUUN3ME2xPU42OzNzIN88US=> MnLaV2FPT0WU
MS-1 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF7Lk[xNFMh|ryP NFXR[XJUSU6JRWK=
NCI-H82 NUHLSYFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zpdGlEPTB;MUmuOlg4QCEQvF2= NWfUbYJ7W0GQR1XS
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LS-123 M2LoWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDaTnVKUUN3ME2yNE4xOTl2IN88US=> NH7CZmdUSU6JRWK=
PC-14 M2nvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJyLkG4N|Qh|ryP M2\3UXNCVkeHUh?=
NCI-H1703 M1rMSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXwR|VKSzVyPUKwMlgyPzNizszN MlXyV2FPT0WU
Calu-6 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG1TWM2OD1{MT6xNFA2KM7:TR?= NGC3dXJUSU6JRWK=
no-11 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH0[FNVUUN3ME2yNU4yPjB{IN88US=> NV;EVot5W0GQR1XS
NCI-H727 NV;nfolbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Pne2lEPTB;MkGuN|Q6OyEQvF2= NV;VW|V3W0GQR1XS
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KYSE-140 M3;tOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fEd2lEPTB;MkGuO|I4OSEQvF2= MX;TRW5ITVJ?
RH-1 NU\Jdm9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfBSpZvUUN3ME2yNU45QDNizszN NXmyd3p7W0GQR1XS
HAL-01 M4m0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLYTWM2OD1{Mj6wOFE5KM7:TR?= NITjfGpUSU6JRWK=
RXF393 M1\jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n2TmlEPTB;MkKuNlc5QSEQvF2= MUnTRW5ITVJ?
LS-411N Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYGyenV[UUN3ME2yNk4zQDZ7IN88US=> MXjTRW5ITVJ?
no-10 M2fxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJ{LkWwNFQh|ryP NXToXXZkW0GQR1XS
MKN7 NIHZbFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jyOmlEPTB;MkKuOlg4KM7:TR?= M3;CcnNCVkeHUh?=
AU565 MoS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrB[HRbUUN3ME2yNk44PDd6IN88US=> NGC3NYRUSU6JRWK=
NUGC-3 M2mwZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\5VllKSzVyPUKzMlEyQTlizszN NHXOfJlUSU6JRWK=
EW-16 M{\aWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTJ2LkC5NlYh|ryP MUfTRW5ITVJ?
HCC70 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vVeWlEPTB;MkSuNVMzOyEQvF2= NUfafIdKW0GQR1XS
RPMI-8226 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTGb3RmUUN3ME2yOE4{OTV3IN88US=> NHvoRY5USU6JRWK=
CFPAC-1 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDsTWM2OD1{ND62NlczKM7:TR?= Mn\HV2FPT0WU
DoTc2-4510 NX:w[HU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2Lke1O|Uh|ryP M1W4RnNCVkeHUh?=
KNS-62 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX0To1RUUN3ME2yOU4xOThizszN NFXz[oJUSU6JRWK=
SK-N-DZ NUG3OVhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn31TWM2OD1{NT6wPVA1KM7:TR?= M3PzbnNCVkeHUh?=
CAL-85-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[5WGlEPTB;MkWuNVU1PCEQvF2= NVz6e2lGW0GQR1XS
JVM-2 NVuzZYFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\nfJdKSzVyPUK1MlIyOjJizszN MlT2V2FPT0WU
NCI-H2347 M1nCe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ3LkSyOFkh|ryP MoPDV2FPT0WU
P30-OHK M2nWeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjSZVluUUN3ME2yOU43OzF6IN88US=> MmSwV2FPT0WU
SK-N-FI Mm[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTJ4LkGxOlIh|ryP Ml;nV2FPT0WU
CAMA-1 NXjRb5dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlL5TWM2OD1{Nj60PFc3KM7:TR?= NHTOdphUSU6JRWK=
MHH-NB-11 M{Hp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom3TWM2OD1{Nj61PFUyKM7:TR?= NXf0e2JDW0GQR1XS
IST-MEL1 NFnGfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ4LkexO|ch|ryP NHPzSJJUSU6JRWK=
KARPAS-299 M4X4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJ5LkS3NFEh|ryP NYXQTnZMW0GQR1XS
TE-11 NGXWe|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PNdWlEPTB;MkeuO|M1OiEQvF2= MoWwV2FPT0WU
769-P M2fVUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjUd5hnUUN3ME2yPE41PTN|IN88US=> M3TtdXNCVkeHUh?=
CAL-72 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXL[4dKSzVyPUK4MlU2PjFizszN MlWwV2FPT0WU
NCI-H2342 MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3KzcmlEPTB;MkmuN|gxOyEQvF2= MnPDV2FPT0WU
NCI-H1651 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPPTWM2OD1{OT64OVA{KM7:TR?= NEfvUlRUSU6JRWK=
OE33 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknNTWM2OD1|MD6xN|QzKM7:TR?= NH3Ve|NUSU6JRWK=
HuP-T4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjlNWR6UUN3ME2zNU41QDN5IN88US=> NXLqfGU3W0GQR1XS
U-118-MG MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjOfJR2UUN3ME2zNk42PDRzIN88US=> MnPpV2FPT0WU
SN12C MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvaR4JKSzVyPUOyMlg5OTVizszN NU\M[lk4W0GQR1XS
TE-5 M2Cy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzTcWNKSzVyPUOzMlE{PjhizszN NEDNNItUSU6JRWK=
KM-H2 M{PGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTN|LkG2PVkh|ryP MWDTRW5ITVJ?
OVCAR-3 NGfmOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrsTJFEUUN3ME2zN{41OTJ5IN88US=> NH:yTm1USU6JRWK=
NCI-H1304 NYPPfoN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfyS5lOUUN3ME2zN{43ODN4IN88US=> MXfTRW5ITVJ?
LU-135 NEXo[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\XNGZKSzVyPUOzMlcxQDZizszN MnjhV2FPT0WU
S-117 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHaPIlVUUN3ME2zN{44Ojh4IN88US=> M2DRe3NCVkeHUh?=
NCI-H1755 M{S1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\jUGlEPTB;M{OuPFEyKM7:TR?= MUDTRW5ITVJ?
Mo-T NUfOb297T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXtTWM2OD1|Mz64OVk{KM7:TR?= NV32OnFbW0GQR1XS
SK-OV-3 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHOc2J[UUN3ME2zN{45QDV2IN88US=> NEHa[WZUSU6JRWK=
RCC10RGB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDVTWM2OD1|Mz65OFM{KM7:TR?= MWDTRW5ITVJ?
COLO-680N NXfRcm5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXuTWM2OD1|ND6xN|k4KM7:TR?= M4[3SXNCVkeHUh?=
KURAMOCHI Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXYdZJjUUN3ME2zOE43PDJ3IN88US=> NWLnPXh7W0GQR1XS
NCI-H661 NEDUWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;6Znh3UUN3ME2zOE45PDR6IN88US=> Ml3FV2FPT0WU
YAPC NX6xW2FyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN3Lkm1N|Mh|ryP MmP1V2FPT0WU
NCI-H526 NHnl[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDrTWM2OD1|Nz6yO|czKM7:TR?= NVHyc3Q1W0GQR1XS
A498 NYDIVHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTMcoI4UUN3ME2zPE4xQTV2IN88US=> NHqzclBUSU6JRWK=
VMRC-RCZ NVj3WIFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN7LkCwOVQh|ryP MVjTRW5ITVJ?
HCT-116 M{D6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnxTWM2OD1|OT6wOVgh|ryP M3XWbnNCVkeHUh?=
COLO-320-HSR M1TnTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKxZYdKSzVyPUSwMlA1OSEQvF2= MYnTRW5ITVJ?
OAW-42 MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\DTlVKSzVyPUSwMlA2PDJizszN NXXkdVdVW0GQR1XS
SK-MEL-1 NHHNfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrwTWM2OD12MD6yPVI4KM7:TR?= NYj1SmtRW0GQR1XS
IST-MES1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRyLke2OVMh|ryP M1fZNnNCVkeHUh?=
CP50-MEL-B Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTlTWM2OD12MT6wO|k4KM7:TR?= M33BOXNCVkeHUh?=
RMG-I NHjOXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETrU|NKSzVyPUSyMlQ6OjFizszN NF\IRodUSU6JRWK=
D-336MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP4TWM2OD12Mz6xNVUzKM7:TR?= MmmxV2FPT0WU
SHP-77 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXDTWM2OD12Mz6xPFI5KM7:TR?= NY\2WFhOW0GQR1XS
SW872 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTR|LkKxNlMh|ryP NFrqN|ZUSU6JRWK=
DBTRG-05MG MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfGfZZKSzVyPUS0MlY6QTZizszN M1:1R3NCVkeHUh?=
COLO-678 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTR3LkewN|Ih|ryP MYnTRW5ITVJ?
EGI-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnMRlRKSzVyPUS3MlE5OzNizszN M2H3PXNCVkeHUh?=
KYSE-70 M121cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmS3TWM2OD12Nz63NlIzKM7:TR?= M1\tT3NCVkeHUh?=
BALL-1 NGjxW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XYcWlEPTB;NEeuPFI2PCEQvF2= MlvhV2FPT0WU
MDA-MB-361 NYDoNG9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\TUppKSzVyPUS4MlA1PiEQvF2= NGHqPWFUSU6JRWK=
NCI-H1838 M4TkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne4TWM2OD12OD6zOFU5KM7:TR?= MYfTRW5ITVJ?
NCI-H1573 NFu0U|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHMTWM2OD12OD62O|g2KM7:TR?= MoLRV2FPT0WU
HCC1395 NH2xSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR6Lkm5NkDPxE1? NXu5dZdmW0GQR1XS
NCI-H2291 M{fVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHVVWhZUUN3ME20PU42QTh6IN88US=> NF;FdnBUSU6JRWK=
RH-18 NHnKRnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTVyLkC4PFQh|ryP MmHiV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID