BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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Cited by 15 Publications

4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

  • (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

  • Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LKOWlEPTB;MD6wN|U5KM7:TR?= MoXJV2FPT0WU
H9 NEnTT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwME[wNVkh|ryP NWfzcYM2W0GQR1XS
KARPAS-45 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMU[1NlUh|ryP NVXrWm1bW0GQR1XS
NCI-H720 NXvjNG5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1myNGlEPTB;MD6xO|E6PCEQvF2= NIHHeYJUSU6JRWK=
CTV-1 M4DUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwNEe4O|Ih|ryP MnmyV2FPT0WU
DU-4475 NGDlSZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNUC0NVch|ryP NV60dFBRW0GQR1XS
A172 MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\HbGlEPTB;MD61NVcxPSEQvF2= MlXtV2FPT0WU
EW-18 NWi5XWpRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jnR2lEPTB;MD62NlIyOSEQvF2= M2\tNXNCVkeHUh?=
KU812 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr0bHhXUUN3ME2wMlYzPjJ|IN88US=> NYiyeFlHW0GQR1XS
KP-N-YS NHq2Z|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fPNWlEPTB;MD62PFIzOyEQvF2= MoO5V2FPT0WU
SBC-1 NV7t[|hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwNkm1NlQh|ryP NHTkWJZUSU6JRWK=
ECC10 NEfl[nVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwN{CwPVQh|ryP NYHU[5FrW0GQR1XS
GAMG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjzdJBUUUN3ME2wMlc1PzF5IN88US=> MUDTRW5ITVJ?
NCI-H209 NFLxRZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ESWlEPTB;MD63OlgzKM7:TR?= MkDLV2FPT0WU
MC-IXC NFPPSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHXfotKSzVyPUCuO|k2QDlizszN M17TOXNCVkeHUh?=
HSC-3 NY[zR4VqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\5TWM2OD1yLkixO|Y6KM7:TR?= M{nZdHNCVkeHUh?=
IST-SL1 NHzlTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjTc|lKSzVyPUCuPFQ2PzRizszN MYHTRW5ITVJ?
LU-139 NGD2RoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X6PGlEPTB;MD64OFk2QCEQvF2= MUPTRW5ITVJ?
ML-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGGzUIhKSzVyPUCuPFU2PzVizszN NFiwRWZUSU6JRWK=
CAL-62 NX;U[XNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3xNoRKUUN3ME2wMlg5OTV{IN88US=> M{W2PHNCVkeHUh?=
HL-60 MlnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLrO4RKSzVyPUCuPFg{PjJizszN MXnTRW5ITVJ?
KY821 Mn;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnpT|lKSzVyPUCuPFg5OTJizszN M1G3SXNCVkeHUh?=
ES7 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL6TWM2OD1yLkmxOlA4KM7:TR?= MYPTRW5ITVJ?
MV-4-11 NUnuVZJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjvepZKSzVyPUCuPVc5QTdizszN MU\TRW5ITVJ?
Daoy NEHqXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorETWM2OD1yLkm4O|Y4KM7:TR?= MlG1V2FPT0WU
EoL-1-cell NVfkNGlFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfydHMyUUN3ME2xMlAyQDd6IN88US=> MXLTRW5ITVJ?
TGW NVHFfJNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe0VnZKSzVyPUGuNFUyOjRizszN MnrqV2FPT0WU
LAMA-84 NF76U2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LuUGlEPTB;MT6xNlc6PCEQvF2= NGPQOYZUSU6JRWK=
KOSC-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2raXGlEPTB;MT6xN|M5PSEQvF2= M2roNXNCVkeHUh?=
A549 NWjE[4wzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXrWZc{UUN3ME2xMlMxQTV3IN88US=> MVXTRW5ITVJ?
CTB-1 M2Dn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLXTWM2OD1zLkS0Olc6KM7:TR?= MV\TRW5ITVJ?
NCI-H292 NV;MelVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTwXlRUUUN3ME2xMlQ3ODZ7IN88US=> Mme1V2FPT0WU
LoVo M1O5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHQOW5KSzVyPUGuOFY4PTVizszN NIrXfZpUSU6JRWK=
BFTC-905 NV6yPYFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vMRmlEPTB;MT61OlM{OiEQvF2= Mlr4V2FPT0WU
BE-13 M1;mN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVni[HlGUUN3ME2xMlU5PzB7IN88US=> MmGzV2FPT0WU
KE-37 NI\CfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nTZWlEPTB;MT61PVQ4QCEQvF2= MXPTRW5ITVJ?
HN NGPxRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIWzVlNKSzVyPUGuOlE{PjhizszN MVPTRW5ITVJ?
A3-KAW MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:xPXNKSzVyPUGuOlI5OzRizszN NHv2eHdUSU6JRWK=
NEC8 NVXOVphwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfTcZVKSzVyPUGuO|AyOTVizszN MYXTRW5ITVJ?
Ramos-2G6-4C10 NGL6TmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlz4TWM2OD1zLkewOFQ1KM7:TR?= MVnTRW5ITVJ?
NB10 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLqT5pYUUN3ME2xMlc4PjNizszN MV7TRW5ITVJ?
NBsusSR M4i3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\qXnA2UUN3ME2xMlgzQTZzIN88US=> MW\TRW5ITVJ?
ES4 NXnHbItET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jtU2lEPTB;MT64OVE1OyEQvF2= MW\TRW5ITVJ?
ES8 NXXINWxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3MZ|ZKSzVyPUGuPFc4OjRizszN MkfpV2FPT0WU
CHL-1 NXXpSY9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TwVmlEPTB;MT65OVc6OiEQvF2= NFHxW3dUSU6JRWK=
NCI-H2029 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LJT2lEPTB;MT65O|I1OSEQvF2= M1zsOnNCVkeHUh?=
YKG-1 MnWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TGV2lEPTB;MT65PFQ{OiEQvF2= NELDVGlUSU6JRWK=
BV-173 NYLJdllmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv4PXJGUUN3ME2xMlk5PjZ4IN88US=> NXzmOoJQW0GQR1XS
697 NVTOTG5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnwVphKSzVyPUKuNFIzOjhizszN NUHoSlROW0GQR1XS
SK-NEP-1 NVLIO3VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjwe3NKSzVyPUKuNFQ1KM7:TR?= MkL4V2FPT0WU
LOXIMVI NGr1ZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGe5bphKSzVyPUKuNFQ1OzRizszN Mn7WV2FPT0WU
QIMR-WIL NFjVOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPPXFd[UUN3ME2yMlA4QDR7IN88US=> M1jqUXNCVkeHUh?=
DU-145 MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHuTWM2OD1{LkGxNFU3KM7:TR?= NVK0S3FuW0GQR1XS
NB14 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmriTWM2OD1{LkGxN|IyKM7:TR?= MkDSV2FPT0WU
G-361 NXi5N4RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfQZmtKSzVyPUKuNVIzOSEQvF2= MoPEV2FPT0WU
BPH-1 NWDnUVJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwMUK5OVch|ryP NX64SWt4W0GQR1XS
KYSE-150 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfMTWM2OD1{LkG1NlM1KM7:TR?= MX\TRW5ITVJ?
HMV-II NV;2Z3RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e3bWlEPTB;Mj6xOlY{OyEQvF2= MmXqV2FPT0WU
TE-9 M3HOSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TNNWlEPTB;Mj6xO|M4PiEQvF2= M3XsOHNCVkeHUh?=
8-MG-BA MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK4XIYyUUN3ME2yMlI{PDZzIN88US=> NE\xN5JUSU6JRWK=
ES5 NU\lXYM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnOTWM2OD1{LkKzOlM{KM7:TR?= NVLtZpd6W0GQR1XS
D-283MED NUW0SlliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;UbZBKSzVyPUKuNlM3QTVizszN NEiyWYJUSU6JRWK=
SK-N-AS NFnzXJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK3U2lKSzVyPUKuNlkxPTlizszN M2DKZnNCVkeHUh?=
SW1710 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLF[XNKSzVyPUKuN|A3PjFizszN NUTYfVBjW0GQR1XS
GCT NF3PV4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n4e2lEPTB;Mj6zNVM2QCEQvF2= MlXKV2FPT0WU
AGS Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rhTGlEPTB;Mj6zOFQxPCEQvF2= MXfTRW5ITVJ?
HuO9 M3qyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG2TWM2OD1{LkO2PFI1KM7:TR?= MX3TRW5ITVJ?
MN-60 M1fNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\x[FdKSzVyPUKuOFQ5QDNizszN NHqyPIlUSU6JRWK=
NB6 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\KXWlKSzVyPUKuOFU4PzlizszN NGOwVHpUSU6JRWK=
NCI-H1395 NEK2eHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJwNEexNlEh|ryP NWLOephRW0GQR1XS
H4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnpPHpkUUN3ME2yMlQ5Ozl|IN88US=> NIW2cHNUSU6JRWK=
HT-3 NFX1b4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fkXGlEPTB;Mj61NVAzPCEQvF2= NYjtUmN3W0GQR1XS
P12-ICHIKAWA MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XpbWlEPTB;Mj61NlU2QSEQvF2= NIPMOZVUSU6JRWK=
COLO-800 M{XVSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7PTWM2OD1{LkW0NVY3KM7:TR?= MmT5V2FPT0WU
DB Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwNUWwNVMh|ryP MnvZV2FPT0WU
LCLC-97TM1 M1:3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTJwNkCwNlgh|ryP NEXqdolUSU6JRWK=
Ca9-22 M4e0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkntTWM2OD1{Lk[1PVM{KM7:TR?= M1zKfXNCVkeHUh?=
Becker MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW1TGtKSzVyPUKuOlYxPzhizszN NY\zWJdtW0GQR1XS
ACN MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLLTWM2OD1{Lk[2O|kh|ryP MVnTRW5ITVJ?
SJSA-1 M3XwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTJwNk[4O{DPxE1? NIjVSlRUSU6JRWK=
NCI-H1048 Ml3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K0R2lEPTB;Mj62PFMzOSEQvF2= MVHTRW5ITVJ?
HEL MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvOdJVKSzVyPUKuO|AzPTRizszN MlnUV2FPT0WU
NCI-H69 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfjdppKSzVyPUKuO|E3ODFizszN NVT2d5B7W0GQR1XS
639-V MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1faOmlEPTB;Mj63NVcxOyEQvF2= M3SweHNCVkeHUh?=
U251 MoDDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJwN{OwN|Ih|ryP NUSzXZBJW0GQR1XS
NCI-H1792 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJwN{O3N|gh|ryP M{W4ZXNCVkeHUh?=
EW-1 MnHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXjTWM2OD1{Lke1N|I5KM7:TR?= NVTCdYJvW0GQR1XS
ME-180 NYLabVFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJwN{e3N|Yh|ryP M33VV3NCVkeHUh?=
HH MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L0cWlEPTB;Mj64NFAxOSEQvF2= M3n5bnNCVkeHUh?=
SW954 Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj4PI5KSzVyPUKuPFU5OyEQvF2= M4L4NXNCVkeHUh?=
SF268 NUewOGx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJwOEeyNlUh|ryP M2TU[nNCVkeHUh?=
D-566MG M{OwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPab3AzUUN3ME2yMlkyOjl3IN88US=> NGXPOFJUSU6JRWK=
EM-2 M2[yRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFr1N4NKSzVyPUKuPVIyQTNizszN MULTRW5ITVJ?
NCI-H1299 M4DnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TEVGlEPTB;Mj65N|c{PiEQvF2= MV\TRW5ITVJ?
PSN1 NEXzdJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXmUXFKSzVyPUOuNFU4QDZizszN M3\hNnNCVkeHUh?=
JVM-3 NH7icWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnhWG1{UUN3ME2zMlA3PzV4IN88US=> M1n0[nNCVkeHUh?=
D-502MG MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;nPWlEPTB;Mz6wO|AyQSEQvF2= NGj5Uo1USU6JRWK=
SCC-4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlviTWM2OD1|LkC5Nlc3KM7:TR?= MlnPV2FPT0WU
GMS-10 NHLEWI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf5TWM2OD1|LkC5N|g5KM7:TR?= NI\DUmFUSU6JRWK=
A427 NHT5XFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW5XY5KSzVyPUOuNVA5PzNizszN M4\ZeHNCVkeHUh?=
NH-12 NVjoepJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH2fnRJUUN3ME2zMlEyPDV4IN88US=> NFHUb4NUSU6JRWK=
KM12 NUTtPGdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNwMUKyO|Mh|ryP MVXTRW5ITVJ?
GI-1 M3yyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfhT5d2UUN3ME2zMlE2OjV3IN88US=> NGqzNZZUSU6JRWK=
TE-8 Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDzTWM2OD1|LkG5NlMyKM7:TR?= MoTrV2FPT0WU
MKN1 NYS5PXRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC2eXRMUUN3ME2zMlIxQDd3IN88US=> MVnTRW5ITVJ?
NCI-H810 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PFNmlEPTB;Mz6yNlE2PSEQvF2= NYXZSpVnW0GQR1XS
GOTO MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNwMkiwNFQh|ryP M2e5WnNCVkeHUh?=
T98G NUDueG1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHMTWM2OD1|LkK4NlE3KM7:TR?= MYXTRW5ITVJ?
HD-MY-Z NFnvelJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPETWM2OD1|LkO2OVQzKM7:TR?= MWnTRW5ITVJ?
SNU-C2B NVrUS|N[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PRR2lEPTB;Mz6zPVA6PyEQvF2= NFi4OXFUSU6JRWK=
MOLT-4 NHvITHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PURmlEPTB;Mz6zPVA6QCEQvF2= M{DHN3NCVkeHUh?=
RPMI-7951 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;6TWM2OD1|LkO5O|Mh|ryP MVXTRW5ITVJ?
EW-11 NGXQOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTNwNEGyNlQh|ryP M13wbnNCVkeHUh?=
RD NYLJOmtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37BfmlEPTB;Mz60N|E{OiEQvF2= M3jCNHNCVkeHUh?=
SW48 M3nTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;VOG1KSzVyPUOuOFM{PThizszN MYTTRW5ITVJ?
BB65-RCC NYLz[pY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rw[mlEPTB;Mz60OVM6PiEQvF2= MkK5V2FPT0WU
Ca-Ski NILyWIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS0[FVKSzVyPUOuOFc2OTRizszN MkXsV2FPT0WU
CHP-134 M3HwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4CwdWlEPTB;Mz60PFc2QCEQvF2= Mnf1V2FPT0WU
CAL-33 NV76S4QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPHTWM2OD1|LkWzN|YzKM7:TR?= NHXYblFUSU6JRWK=
TYK-nu Mo\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTNwNUO2O|Yh|ryP M{Wy[3NCVkeHUh?=
LB831-BLC MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNwNUSwNVYh|ryP NGP0fIJUSU6JRWK=
KU-19-19 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTNwNkCzNFQh|ryP NFLxWY1USU6JRWK=
KG-1 NXHleppnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTNwNkGxNFYh|ryP MWjTRW5ITVJ?
COLO-829 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzsTWM2OD1|Lk[2OlE5KM7:TR?= NETLV5FUSU6JRWK=
HUTU-80 MmnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[y[mlEPTB;Mz62OlYzOSEQvF2= NX7CdWhoW0GQR1XS
NCI-H446 M3fqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmxTWM2OD1|Lk[4N|Qh|ryP Mn\TV2FPT0WU
LB2241-RCC M{nVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTNwNki2NlUh|ryP MmjTV2FPT0WU
JEG-3 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTNwNkmxPUDPxE1? M3\Nd3NCVkeHUh?=
LNCaP-Clone-FGC NV3kWopHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ize2lEPTB;Mz63NFA1OSEQvF2= NFfVbolUSU6JRWK=
M059J MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX2xepJmUUN3ME2zMlcyPDZ6IN88US=> Mo\nV2FPT0WU
SK-MES-1 M4jCbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjEXnFKSzVyPUOuO|MxOyEQvF2= M{fsc3NCVkeHUh?=
GT3TKB Mn3hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m5TmlEPTB;Mz63OVYxPCEQvF2= NWDjXWZjW0GQR1XS
DOK Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf3TWM2OD1|Lke2OVI3KM7:TR?= NFq5[WFUSU6JRWK=
HO-1-N-1 M3S2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;3U3NKSzVyPUOuO|k5ODFizszN NE\ETVhUSU6JRWK=
MZ1-PC NHPCUIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrXd5NKSzVyPUOuPFI5QDNizszN NYTrNplQW0GQR1XS
8305C NUK4OpJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnzTWM2OD1|Lki4PVQ{KM7:TR?= MnHSV2FPT0WU
CGTH-W-1 NXzxOnk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHqOnJKSzVyPUOuPVM2ODRizszN MUfTRW5ITVJ?
LU-134-A MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW2TWM2OD1|Lkm1OFIzKM7:TR?= NUHVVVhHW0GQR1XS
C32 NGTJRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvmdG56UUN3ME2zMlk3PThzIN88US=> M{jlZXNCVkeHUh?=
MOLT-13 NEDPT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNwOU[4OVYh|ryP MXvTRW5ITVJ?
A375 NXvtS495T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj4cJRYUUN3ME20MlA2OTZ{IN88US=> NYLvOJF{W0GQR1XS
CAL-12T NIDte4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvzRZd[UUN3ME20MlA2Pzl3IN88US=> NVe2XnBjW0GQR1XS
IGR-1 M2H2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW0dG8xUUN3ME20MlExOjd2IN88US=> M4rZe3NCVkeHUh?=
LB1047-RCC MofBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3yVHVKSzVyPUSuNVA1PDFizszN MXvTRW5ITVJ?
BHT-101 M2H1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTRwMUC2PFMh|ryP NHPN[VRUSU6JRWK=
A431 M{PuR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\0TWlEPTB;ND6xOFA5OSEQvF2= MVrTRW5ITVJ?
EPLC-272H MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{POO2lEPTB;ND6xO|U6PiEQvF2= NXXmOm1SW0GQR1XS
HT-1376 M2HVZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr6SXBKSzVyPUSuNlMxPTlizszN M1HUeHNCVkeHUh?=
HCC1954 NXvOUo9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrJS4JuUUN3ME20MlI2PzR4IN88US=> NW\jVZJ5W0GQR1XS
KYSE-510 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTRwMk[wPUDPxE1? M3KxRnNCVkeHUh?=
PANC-03-27 M1HyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XmeWlEPTB;ND6zNFA5OyEQvF2= MW\TRW5ITVJ?
MDA-MB-157 NGCyNoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fXdGlEPTB;ND6zNFY2PiEQvF2= M{\jVXNCVkeHUh?=
HOP-62 MlrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D2O2lEPTB;ND6zNFg2PiEQvF2= NXXlb29nW0GQR1XS
ETK-1 M2Twbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonDTWM2OD12LkO2NlA{KM7:TR?= NHTt[IVUSU6JRWK=
MIA-PaCa-2 M13jWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jRO2lEPTB;ND6zOlIzPyEQvF2= MVPTRW5ITVJ?
MHH-PREB-1 NHq3dGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvnU3lKSzVyPUSuN|k4PzNizszN MnPHV2FPT0WU
LXF-289 NEWyNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWwNYQ3UUN3ME20MlQxOjB{IN88US=> MUDTRW5ITVJ?
ATN-1 MnXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe1Wmc1UUN3ME20MlQzOzRzIN88US=> NFroXWFUSU6JRWK=
8505C MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\ITWlEPTB;ND60OVgzPSEQvF2= NGT1WGJUSU6JRWK=
HOS M3GyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3QTWM2OD12LkS2OFU{KM7:TR?= MWrTRW5ITVJ?
U-266 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTRwNkGwN|Ih|ryP NVfJO2p7W0GQR1XS
5637 NHm3VWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LH[2lEPTB;ND62NVQ1PCEQvF2= M1TJb3NCVkeHUh?=
GCIY NVeybWxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmzd5NKSzVyPUSuO|ExOTVizszN NX;pOVhkW0GQR1XS
MDA-MB-231 NH;yb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnETWM2OD12LkeyNVE2KM7:TR?= MXjTRW5ITVJ?
RKO MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvZR4g2UUN3ME20MlczQDF5IN88US=> Mn;5V2FPT0WU
COR-L23 M{LUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvFeYlKSzVyPUSuO|QzPTZizszN M2jhfnNCVkeHUh?=
DJM-1 NIXZNJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7HdWtKSzVyPUSuO|k4OjlizszN M1:zPHNCVkeHUh?=
D-423MG M3TZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnztTWM2OD12LkiwPFA{KM7:TR?= NW\SNZNYW0GQR1XS
DMS-114 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHmzOIlKSzVyPUSuPFE{QDZizszN NXrlXXlnW0GQR1XS
MHH-ES-1 M1\LZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTNdnc3UUN3ME20MlgzPTB2IN88US=> MX;TRW5ITVJ?
CAL-51 NVvRNFBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjFTWM2OD12Lki2PFQ{KM7:TR?= MkT1V2FPT0WU
SW626 MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvhbYRKSzVyPUSuPFk3QTdizszN MXjTRW5ITVJ?
COLO-824 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;0WJJKSzVyPUSuPVA1ODhizszN NYG3SXB1W0GQR1XS
NCI-H1437 NVHuTm51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;jSWg{UUN3ME20MlkzQTNizszN NYLodGpxW0GQR1XS
CAL-39 M3v5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwOUO5PFgh|ryP MVXTRW5ITVJ?
PC-3 M{Tt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTRwOUS2OFgh|ryP NXXYe|hnW0GQR1XS
A101D Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jjSmlEPTB;ND65Olg3PSEQvF2= MoXtV2FPT0WU
ES1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTVwMECxN{DPxE1? Mlr3V2FPT0WU
TE-1 NG\SVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;uTWM2OD13LkCzOlY3KM7:TR?= NXPUTmNQW0GQR1XS
KP-N-YN NULxVJM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTVwMEW2O{DPxE1? MVvTRW5ITVJ?
EFO-27 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLvTWM2OD13LkC2N|I6KM7:TR?= MkDSV2FPT0WU
BT-549 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLmTWM2OD13LkC3O|M3KM7:TR?= M1;udHNCVkeHUh?=
HLE NGT4bo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLvRVUzUUN3ME21MlEyPzN2IN88US=> M2TZdHNCVkeHUh?=
SW982 M{[w[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwMUOzO|Qh|ryP NF\6RWVUSU6JRWK=
SCC-25 M1TsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fDWWlEPTB;NT6xPVA1PiEQvF2= M4PJRnNCVkeHUh?=
SK-MEL-28 NGnyb49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTVwMkCzNVMh|ryP M4XS[XNCVkeHUh?=
CaR-1 M2LLfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULOfVBkUUN3ME21MlIxPzJ4IN88US=> NIXkZ5hUSU6JRWK=
MLMA NYmxXHNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTVwMkO0N|Yh|ryP NYPiR4xJW0GQR1XS
VM-CUB-1 M4jM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnSUYJ1UUN3ME21MlI{PDN7IN88US=> MV7TRW5ITVJ?
KNS-42 M4LMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LWR2lEPTB;NT6yOlE3KM7:TR?= NI\BNVlUSU6JRWK=
TK10 NEKyc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnGTWM2OD13LkO2NFg3KM7:TR?= MlixV2FPT0WU
MEG-01 NFzRXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfDe2lKSzVyPUWuN|YzPzRizszN NHX3OHRUSU6JRWK=
DEL NIW4bINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u2R2lEPTB;NT6zPVAzOyEQvF2= NV;aNHByW0GQR1XS
SJRH30 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLDTWM2OD13LkO5NlE{KM7:TR?= NIHvT2RUSU6JRWK=
SK-PN-DW NXiyRYdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPoTWM2OD13LkSzOVg6KM7:TR?= NIG3fVBUSU6JRWK=
TE-10 NWHUS5ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPBTWM2OD13LkS0PFk{KM7:TR?= MlzpV2FPT0WU
KNS-81-FD M3iw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\pWmxKSzVyPUWuOVAxQTJizszN M2L6eXNCVkeHUh?=
BHY NXi2fWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnntTWM2OD13LkWxNFch|ryP NXXtUlBxW0GQR1XS
KYSE-270 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTpTWM2OD13LkWzOVM3KM7:TR?= M4jwUHNCVkeHUh?=
NCI-H650 M37OSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmzeXBkUUN3ME21MlU4OTF2IN88US=> NXPUUIZ2W0GQR1XS
L-363 M37ldmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfyTGVJUUN3ME21MlY6PDd4IN88US=> NWT3NlVDW0GQR1XS
TCCSUP NHLTN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofJTWM2OD13LkexO|c5KM7:TR?= NGnROYRUSU6JRWK=
SCH NHXNfWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HpeGlEPTB;NT63OFc3PyEQvF2= MULTRW5ITVJ?
HTC-C3 NHToNFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVeyU29qUUN3ME21Mlc4PjR2IN88US=> MoHUV2FPT0WU
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Hs-578-T M2mxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;UPFJjUUN3ME21Mlg{PjB5IN88US=> NX3hdlh4W0GQR1XS
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HT-144 Mkf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SzeWlEPTB;NT64Olg{OiEQvF2= NWexdphwW0GQR1XS
CAL-54 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUKyTId6UUN3ME21Mlk{OzF2IN88US=> NE\PbYRUSU6JRWK=
T47D MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;mO3NKSzVyPUWuPVYyOiEQvF2= M4CyfHNCVkeHUh?=
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HSC-2 M37qdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGmzV3NKSzVyPU[uNVI{PTNizszN M{XxOnNCVkeHUh?=
SiHa MkLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjkWplKSzVyPU[uNVQxQTdizszN NV\QZlM3W0GQR1XS
OMC-1 NV\K[INyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HtV2lEPTB;Nj6zOVQ1OSEQvF2= Mn6yV2FPT0WU
HGC-27 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTlc5VKSzVyPU[uN|U4QDZizszN M3KxbXNCVkeHUh?=
FTC-133 MmrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTZwNE[1OVEh|ryP MmSyV2FPT0WU
KS-1 M33sTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\1XGRKSzVyPU[uOVIyPDdizszN MmXWV2FPT0WU
HT-1080 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzBTWM2OD14LkW0NFQzKM7:TR?= NIHQc4pUSU6JRWK=
SKG-IIIa NF7TSYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTZwNU[yOlMh|ryP MX\TRW5ITVJ?
OCUB-M NXnMN|BET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvoRmFmUUN3ME22MlYxPzdizszN MX3TRW5ITVJ?
MDA-MB-175-VII NVmxcWdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTEeZd6UUN3ME22MlYzODlizszN NHHNbGRUSU6JRWK=
BB30-HNC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTZwNke0OFQh|ryP MkL2V2FPT0WU
D-542MG NY\WSZVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTC[JlFUUN3ME22Mlc{ODlizszN NUiyeVFPW0GQR1XS
NCI-H2405 NUnx[VBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HHfmlEPTB;Nj63OFg2PSEQvF2= M1nwRnNCVkeHUh?=
SW1573 NFPKWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTZwN{izNVkh|ryP NX7TOVZPW0GQR1XS
NCI-SNU-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWycYpKSzVyPU[uO|kxOjJizszN NVn3VpJ7W0GQR1XS
RT-112 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPrTWM2OD14Lke5OFY{KM7:TR?= M2\0R3NCVkeHUh?=
COR-L88 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXQZW1KSzVyPU[uO|k4QTFizszN NEPmeZZUSU6JRWK=
SCC-9 M4PMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfvSG9KSzVyPU[uPFI2PSEQvF2= NWLGV3VZW0GQR1XS
U-87-MG MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\2VmRJUUN3ME22Mlg{QDJ4IN88US=> M2DzN3NCVkeHUh?=
Detroit562 NGXDS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTZwOEW5PVEh|ryP M{faeXNCVkeHUh?=
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LCLC-103H M2XTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXriSVF3UUN3ME2xPE4xPTFizszN M{DFPHNCVkeHUh?=
NCI-H520 NXraRld6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjnWoJiUUN3ME2xPE4{OjhzIN88US=> M3TyVXNCVkeHUh?=
LU-65 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF6LkSwOFMh|ryP M{LUS3NCVkeHUh?=
SK-MEL-3 NEjJZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTQNm5KSzVyPUG4MlY3PzlizszN MW\TRW5ITVJ?
LK-2 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF6Lke3NlMh|ryP NV;Pe4d1W0GQR1XS
PANC-08-13 M4DpO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF6Lke4PFkh|ryP NYP5R2pUW0GQR1XS
NCI-H460 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\0dGlEPTB;MUiuPFQ3PiEQvF2= M2HXXXNCVkeHUh?=
COLO-684 NVXNN2xrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnFTWM2OD1zOD65PVU3KM7:TR?= MlHSV2FPT0WU
RPMI-2650 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr0W253UUN3ME2xPU4xOTJizszN MoTIV2FPT0WU
NY M4TQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULweYp3UUN3ME2xPU4yPTZ5IN88US=> MYDTRW5ITVJ?
NB7 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPkTWM2OD1zOT6xO|U{KM7:TR?= M4XJTXNCVkeHUh?=
NCI-H358 MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\PTWM2OD1zOT6yOlc{KM7:TR?= M4nTcnNCVkeHUh?=
MC116 NVzxd4o{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF7LkWzN|Eh|ryP MXvTRW5ITVJ?
MS-1 NHTWbYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fONWlEPTB;MUmuOlExOyEQvF2= NW\oTXYzW0GQR1XS
NCI-H82 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF7Lk[4O|gh|ryP NVqwfIhlW0GQR1XS
OCI-AML2 M3uzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTF7LkewN|Ih|ryP NEPyc25USU6JRWK=
LS-123 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;XTWM2OD1{MD6wNVk1KM7:TR?= NUe2WWtjW0GQR1XS
PC-14 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHt[4JKSzVyPUKwMlE5OzRizszN NVP0Z|BkW0GQR1XS
NCI-H1703 MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yxOGlEPTB;MkCuPFE4OyEQvF2= MX\TRW5ITVJ?
Calu-6 NYrYdmhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC5V|FmUUN3ME2yNU4yODB3IN88US=> NVXkV2FSW0GQR1XS
no-11 NH7NcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTaZnVTUUN3ME2yNU4yPjB{IN88US=> NVzkdnZYW0GQR1XS
NCI-H727 MmnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XsT2lEPTB;MkGuN|Q6OyEQvF2= NIHiN2RUSU6JRWK=
DSH1 M4XVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJzLkO4O|kh|ryP MkPnV2FPT0WU
KYSE-140 M3nWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7iUJRKSzVyPUKxMlczPzFizszN NU[4U21TW0GQR1XS
RH-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HoZ2lEPTB;MkGuPFg{KM7:TR?= M{XvUHNCVkeHUh?=
HAL-01 NFS2XFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfVTWM2OD1{Mj6wOFE5KM7:TR?= Ml;zV2FPT0WU
RXF393 NYTLWnFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\ETWM2OD1{Mj6yO|g6KM7:TR?= NEDa[2FUSU6JRWK=
LS-411N NVn6[4V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fOdWlEPTB;MkKuNlg3QSEQvF2= MmC1V2FPT0WU
no-10 NVy1WGx5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ{LkWwNFQh|ryP MoPjV2FPT0WU
MKN7 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi4d5RKSzVyPUKyMlY5PyEQvF2= NGjqfG1USU6JRWK=
AU565 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjxPXJKSzVyPUKyMlc1PzhizszN MXXTRW5ITVJ?
NUGC-3 NUHaXGs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLBdFVKSzVyPUKzMlEyQTlizszN NGfuTYFUSU6JRWK=
EW-16 NFzuVlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv4SGRKSzVyPUK0MlA6OjZizszN M2r3U3NCVkeHUh?=
HCC70 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\TVJM1UUN3ME2yOE4yOzJ|IN88US=> MYPTRW5ITVJ?
RPMI-8226 NWrkWI5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ2LkOxOVUh|ryP NVTCTGd2W0GQR1XS
CFPAC-1 NGfzU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PYdWlEPTB;MkSuOlI4OiEQvF2= Mke5V2FPT0WU
DoTc2-4510 M2rpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJ2Lke1O|Uh|ryP NV:0b456W0GQR1XS
KNS-62 NWr5WZhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ3LkCxPEDPxE1? NImxPGNUSU6JRWK=
SK-N-DZ MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ3LkC5NFQh|ryP NILIUW5USU6JRWK=
CAL-85-1 NWjneoV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIe4dWdKSzVyPUK1MlE2PDRizszN NXriWZp4W0GQR1XS
JVM-2 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ3LkKxNlIh|ryP NUHtOGQ6W0GQR1XS
NCI-H2347 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjndm1KSzVyPUK1MlQzPDlizszN M1G1NXNCVkeHUh?=
P30-OHK NFvxSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3LTWM2OD1{NT62N|E5KM7:TR?= MX7TRW5ITVJ?
SK-N-FI MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;4ZWw3UUN3ME2yOk4yOTZ{IN88US=> MnvIV2FPT0WU
CAMA-1 NIPVbFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfU[5AzUUN3ME2yOk41QDd4IN88US=> MnfGV2FPT0WU
MHH-NB-11 NEniV5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ4LkW4OVEh|ryP NXvndWVQW0GQR1XS
IST-MEL1 NELLUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HYb2lEPTB;Mk[uO|E4PyEQvF2= NHHvZllUSU6JRWK=
KARPAS-299 NInDSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXGTWM2OD1{Nz60O|AyKM7:TR?= MlTKV2FPT0WU
TE-11 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTJ5LkezOFIh|ryP Mn;GV2FPT0WU
769-P Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T6XGlEPTB;MkiuOFU{OyEQvF2= MYrTRW5ITVJ?
CAL-72 NXy0TnR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DnSmlEPTB;MkiuOVU3OSEQvF2= MV7TRW5ITVJ?
NCI-H2342 NFzTXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\iT2FKSzVyPUK5MlM5ODNizszN NH\UTVNUSU6JRWK=
NCI-H1651 M4LrcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\JOGVxUUN3ME2yPU45PTB|IN88US=> NVTDW4w3W0GQR1XS
OE33 M3P2emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTNyLkGzOFIh|ryP MU\TRW5ITVJ?
HuP-T4 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTRTWM2OD1|MT60PFM4KM7:TR?= NVPFO5JFW0GQR1XS
U-118-MG MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfKNGw{UUN3ME2zNk42PDRzIN88US=> NGHITlRUSU6JRWK=
SN12C M{jkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHu[opKSzVyPUOyMlg5OTVizszN MXXTRW5ITVJ?
TE-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[2TWM2OD1|Mz6xN|Y5KM7:TR?= NIPmOnZUSU6JRWK=
KM-H2 NILvN3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUf5fW4xUUN3ME2zN{4yPjl7IN88US=> M{PRVXNCVkeHUh?=
OVCAR-3 NYnkTZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[zTWM2OD1|Mz60NVI4KM7:TR?= M{fl[HNCVkeHUh?=
NCI-H1304 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rQ[GlEPTB;M{OuOlA{PiEQvF2= M3LjcnNCVkeHUh?=
LU-135 NY\sNJZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTN|LkewPFYh|ryP MU\TRW5ITVJ?
S-117 NFvxN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLrTGZVUUN3ME2zN{44Ojh4IN88US=> NIX3TpZUSU6JRWK=
NCI-H1755 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LRdmlEPTB;M{OuPFEyKM7:TR?= M1P0VnNCVkeHUh?=
Mo-T NXf6UFFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\5OlVKSzVyPUOzMlg2QTNizszN NHvYNmNUSU6JRWK=
SK-OV-3 M1HxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTN|Lki4OVQh|ryP NXPwSm81W0GQR1XS
RCC10RGB M3Tzfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXKOHVkUUN3ME2zN{46PDN|IN88US=> MXjTRW5ITVJ?
COLO-680N MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\ZeFdKSzVyPUO0MlE{QTdizszN M3P3WHNCVkeHUh?=
KURAMOCHI MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnBVm5KSzVyPUO0MlY1OjVizszN Mn7BV2FPT0WU
NCI-H661 NYfXW4F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnjfmU2UUN3ME2zOE45PDR6IN88US=> NUDDVVVRW0GQR1XS
YAPC M4T5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYL4VldEUUN3ME2zOU46PTN|IN88US=> NGWzepNUSU6JRWK=
NCI-H526 MljwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTN5LkK3O|Ih|ryP MYrTRW5ITVJ?
A498 NEPQRnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoC0TWM2OD1|OD6wPVU1KM7:TR?= NUnjSVByW0GQR1XS
VMRC-RCZ MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTN7LkCwOVQh|ryP NUjwcG0zW0GQR1XS
HCT-116 M4LuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuycm5oUUN3ME2zPU4xPThizszN M17ybXNCVkeHUh?=
COLO-320-HSR NHWzSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;sTWM2OD12MD6wOFEh|ryP MUHTRW5ITVJ?
OAW-42 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLhc3lZUUN3ME20NE4xPTR{IN88US=> M2PlZXNCVkeHUh?=
SK-MEL-1 NED2VHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTRyLkK5Nlch|ryP M4m1XXNCVkeHUh?=
IST-MES1 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITLUFZKSzVyPUSwMlc3PTNizszN M3[5OXNCVkeHUh?=
CP50-MEL-B M4O5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyyV5B{UUN3ME20NU4xPzl5IN88US=> MlrHV2FPT0WU
RMG-I NXzufG1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTR{LkS5NlEh|ryP MnvnV2FPT0WU
D-336MG M4jvNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPMTWM2OD12Mz6xNVUzKM7:TR?= NVnRcVBZW0GQR1XS
SHP-77 M{DwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\zcZRXUUN3ME20N{4yQDJ6IN88US=> MonUV2FPT0WU
SW872 MoPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:zPWFVUUN3ME20N{4zOTJ|IN88US=> M{X5N3NCVkeHUh?=
DBTRG-05MG NF[1WlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\MTWM2OD12ND62PVk3KM7:TR?= Mk\GV2FPT0WU
COLO-678 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLqcJFWUUN3ME20OU44ODN{IN88US=> M3zQbXNCVkeHUh?=
EGI-1 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfQVHpKSzVyPUS3MlE5OzNizszN NI\2[FlUSU6JRWK=
KYSE-70 NV;aZXhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLTV|dKSzVyPUS3MlczOjJizszN M3W0fnNCVkeHUh?=
BALL-1 NFzXelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\jPXVFUUN3ME20O{45OjV2IN88US=> NFvkTIxUSU6JRWK=
MDA-MB-361 NWr2dGY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PZWGlEPTB;NEiuNFQ3KM7:TR?= Moi1V2FPT0WU
NCI-H1838 NWL4WGFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2C4XGlEPTB;NEiuN|Q2QCEQvF2= NFzrVWxUSU6JRWK=
NCI-H1573 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PiNmlEPTB;NEiuOlc5PSEQvF2= MYjTRW5ITVJ?
HCC1395 NWOxSYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTVTWM2OD12OD65PVIh|ryP NFT1fopUSU6JRWK=
NCI-H2291 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfQN|F7UUN3ME20PU42QTh6IN88US=> Ml7BV2FPT0WU
RH-18 MnnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4eyfGlEPTB;NUCuNFg5PCEQvF2= M13IUXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

17040210 28415756 25395420
Immunofluorescence
PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

25002506
Growth inhibition assay
Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

28415756

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

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