BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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Cited by 9 Publications

4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

    (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NWTYXVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PKZ2lEPTB;MD6wN|U5KM7:TR?= NWP1NmRmW0GQR1XS
H9 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwME[wNVkh|ryP NIrEcY1USU6JRWK=
KARPAS-45 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3lfHUzUUN3ME2wMlE3PTJ3IN88US=> NWf0Z2hnW0GQR1XS
NCI-H720 M4fUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMUexPVQh|ryP NEDVWllUSU6JRWK=
CTV-1 NUDXU2RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rUdGlEPTB;MD60O|g4OiEQvF2= MkPZV2FPT0WU
DU-4475 MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH4b2dmUUN3ME2wMlUxPDF5IN88US=> M3vmNHNCVkeHUh?=
A172 M2\R[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkS1TWM2OD1yLkWxO|A2KM7:TR?= MVnTRW5ITVJ?
EW-18 M17zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jrcGlEPTB;MD62NlIyOSEQvF2= NYXMSZprW0GQR1XS
KU812 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzORpR[UUN3ME2wMlYzPjJ|IN88US=> MUnTRW5ITVJ?
KP-N-YS MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTFTWM2OD1yLk[4NlI{KM7:TR?= MUXTRW5ITVJ?
SBC-1 MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPl[WxWUUN3ME2wMlY6PTJ2IN88US=> MknVV2FPT0WU
ECC10 NVTjPXRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXT3cmNrUUN3ME2wMlcxODl2IN88US=> NETHe3VUSU6JRWK=
GAMG M3rTUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwN{S3NVch|ryP MkDaV2FPT0WU
NCI-H209 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwN{[4NkDPxE1? NYTBW5RsW0GQR1XS
MC-IXC NIXWcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHRc3ZKSzVyPUCuO|k2QDlizszN MXXTRW5ITVJ?
HSC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LtVmlEPTB;MD64NVc3QSEQvF2= MoCyV2FPT0WU
IST-SL1 M4n1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr1WYZ1UUN3ME2wMlg1PTd2IN88US=> NYjvN|JPW0GQR1XS
LU-139 NVzT[2t5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwOES5OVgh|ryP MlzFV2FPT0WU
ML-2 Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLYNVVbUUN3ME2wMlg2PTd3IN88US=> NGPCPXpUSU6JRWK=
CAL-62 NGDXXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwOEixOVIh|ryP NYm0Vpg1W0GQR1XS
HL-60 M2TPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXS5[pNRUUN3ME2wMlg5OzZ{IN88US=> NXLMVm42W0GQR1XS
KY821 NIHPUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\rTWM2OD1yLki4PFEzKM7:TR?= M2TwcHNCVkeHUh?=
ES7 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXpSZVKSzVyPUCuPVE3ODdizszN MXLTRW5ITVJ?
MV-4-11 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXnTWM2OD1yLkm3PFk4KM7:TR?= Mn3tV2FPT0WU
Daoy NXXZ[XN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTjTo5KSzVyPUCuPVg4PjdizszN MXXTRW5ITVJ?
EoL-1-cell M13QUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn4TmhKSzVyPUGuNFE5PzhizszN M4qxU3NCVkeHUh?=
TGW NXTRO|RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHpeWlNUUN3ME2xMlA2OTJ2IN88US=> MUfTRW5ITVJ?
LAMA-84 M4\GNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHDTWM2OD1zLkGyO|k1KM7:TR?= NGLOfXdUSU6JRWK=
KOSC-2 M2DPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnBOJJYUUN3ME2xMlE{Ozh3IN88US=> M1r3W3NCVkeHUh?=
A549 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTyTWM2OD1zLkOwPVU2KM7:TR?= NUTQbmNxW0GQR1XS
CTB-1 M4XENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnriTWM2OD1zLkS0Olc6KM7:TR?= MYfTRW5ITVJ?
NCI-H292 NHO5T4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi3TWM2OD1zLkS2NFY6KM7:TR?= MYrTRW5ITVJ?
LoVo MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrLc4lFUUN3ME2xMlQ3PzV3IN88US=> NEPUXW5USU6JRWK=
BFTC-905 NX;1fGp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfYXXZGUUN3ME2xMlU3OzN{IN88US=> MlvTV2FPT0WU
BE-13 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;qTWM2OD1zLkW4O|A6KM7:TR?= MWLTRW5ITVJ?
KE-37 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Htb2lEPTB;MT61PVQ4QCEQvF2= MVTTRW5ITVJ?
HN M1\DO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPpe4MzUUN3ME2xMlYyOzZ6IN88US=> MlXVV2FPT0WU
A3-KAW NWm0e4hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHBTWM2OD1zLk[yPFM1KM7:TR?= MULTRW5ITVJ?
NEC8 NFLSeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3iwVWlEPTB;MT63NFEyPSEQvF2= MV\TRW5ITVJ?
Ramos-2G6-4C10 NVHtO5QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPQe2RKSzVyPUGuO|A1PDRizszN M3\rcXNCVkeHUh?=
NB10 NVfU[XJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TqSmlEPTB;MT63O|Y{KM7:TR?= MoS5V2FPT0WU
NBsusSR NIjQWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET3eW5KSzVyPUGuPFI6PjFizszN NXLwSIhPW0GQR1XS
ES4 MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\seGlEPTB;MT64OVE1OyEQvF2= M3:5NnNCVkeHUh?=
ES8 MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPobopbUUN3ME2xMlg4PzJ2IN88US=> MmfFV2FPT0WU
CHL-1 M{K3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrkU5ppUUN3ME2xMlk2Pzl{IN88US=> M3jV[HNCVkeHUh?=
NCI-H2029 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPsfotRUUN3ME2xMlk4OjRzIN88US=> MWTTRW5ITVJ?
YKG-1 Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfwdYh1UUN3ME2xMlk5PDN{IN88US=> NV3PN|ZoW0GQR1XS
BV-173 MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDsfIdiUUN3ME2xMlk5PjZ4IN88US=> NG\PV2FUSU6JRWK=
697 M{\DS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfqT5FNUUN3ME2yMlAzOjJ6IN88US=> NX3GVIR7W0GQR1XS
SK-NEP-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJwMES0JO69VQ>? M2XPbXNCVkeHUh?=
LOXIMVI M1vucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LCNmlEPTB;Mj6wOFQ{PCEQvF2= NVy3ZVJNW0GQR1XS
QIMR-WIL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnVTWM2OD1{LkC3PFQ6KM7:TR?= MlHJV2FPT0WU
DU-145 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJwMUGwOVYh|ryP MnryV2FPT0WU
NB14 NV7aXWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\vOHlKSzVyPUKuNVE{OjFizszN NUGwWIJZW0GQR1XS
G-361 NFXkWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTPZ21KSzVyPUKuNVIzOSEQvF2= M{LoVnNCVkeHUh?=
BPH-1 NIe2dGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHFTWM2OD1{LkGyPVU4KM7:TR?= MX3TRW5ITVJ?
KYSE-150 NGnUb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnhV4tKUUN3ME2yMlE2OjN2IN88US=> Ml3LV2FPT0WU
HMV-II M2rFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfneHVpUUN3ME2yMlE3PjN|IN88US=> MUTTRW5ITVJ?
TE-9 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTSTYhKSzVyPUKuNVc{PzZizszN MWfTRW5ITVJ?
8-MG-BA MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJwMkO0OlEh|ryP M{nXd3NCVkeHUh?=
ES5 M{HyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTkTWM2OD1{LkKzOlM{KM7:TR?= M3\udHNCVkeHUh?=
D-283MED NXy2c4tOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwMkO2PVUh|ryP M{LKRXNCVkeHUh?=
SK-N-AS NHfuTZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTRWoN[UUN3ME2yMlI6ODV7IN88US=> MVTTRW5ITVJ?
SW1710 NIq1R4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nTe2lEPTB;Mj6zNFY3OSEQvF2= M{TyZXNCVkeHUh?=
GCT Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJwM{GzOVgh|ryP MkO3V2FPT0WU
AGS NULmZYZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjDdGJKSzVyPUKuN|Q1ODRizszN MV;TRW5ITVJ?
HuO9 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTJwM{[4NlQh|ryP NHWzNG9USU6JRWK=
MN-60 M37R[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJwNES4PFMh|ryP MlLIV2FPT0WU
NB6 MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwNEW3O|kh|ryP NW\2XnNwW0GQR1XS
NCI-H1395 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP1TWM2OD1{LkS3NVIyKM7:TR?= MVPTRW5ITVJ?
H4 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXH[lVEUUN3ME2yMlQ5Ozl|IN88US=> MmXpV2FPT0WU
HT-3 MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LyVWlEPTB;Mj61NVAzPCEQvF2= M4rpbHNCVkeHUh?=
P12-ICHIKAWA Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f4V2lEPTB;Mj61NlU2QSEQvF2= MULTRW5ITVJ?
COLO-800 NXjicWh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXLOGNEUUN3ME2yMlU1OTZ4IN88US=> MX7TRW5ITVJ?
DB MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTJwNUWwNVMh|ryP NUTmeWlFW0GQR1XS
LCLC-97TM1 NU\EVWkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrROphKSzVyPUKuOlAxOjhizszN MVHTRW5ITVJ?
Ca9-22 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DxUmlEPTB;Mj62OVk{OyEQvF2= NGrEdlZUSU6JRWK=
Becker MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml75TWM2OD1{Lk[2NFc5KM7:TR?= MVzTRW5ITVJ?
ACN MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPXfllHUUN3ME2yMlY3PzlizszN MnTjV2FPT0WU
SJSA-1 NEfuXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJwNk[4O{DPxE1? MYHTRW5ITVJ?
NCI-H1048 M4jiZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV32Z|Y1UUN3ME2yMlY5OzJzIN88US=> MYXTRW5ITVJ?
HEL NFrKO|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfCNWlrUUN3ME2yMlcxOjV2IN88US=> Mlq2V2FPT0WU
NCI-H69 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJwN{G2NFEh|ryP MkXJV2FPT0WU
639-V MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJwN{G3NFMh|ryP MkG5V2FPT0WU
U251 M{T0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJwN{OwN|Ih|ryP MYHTRW5ITVJ?
NCI-H1792 NWOxZ5h7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPITokxUUN3ME2yMlc{PzN6IN88US=> NXfsZ3VOW0GQR1XS
EW-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Dyc2lEPTB;Mj63OVMzQCEQvF2= NE\XNYJUSU6JRWK=
ME-180 M3S1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTnTWM2OD1{Lke3O|M3KM7:TR?= MWDTRW5ITVJ?
HH MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[w[GlKSzVyPUKuPFAxODFizszN M3y5[XNCVkeHUh?=
SW954 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvPSZRKSzVyPUKuPFU5OyEQvF2= M4j1fXNCVkeHUh?=
SF268 NWjSWnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXUUI1[UUN3ME2yMlg4OjJ3IN88US=> NEjYR2tUSU6JRWK=
D-566MG MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\HTWM2OD1{LkmxNlk2KM7:TR?= MlK3V2FPT0WU
EM-2 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:3PGlEPTB;Mj65NlE6OyEQvF2= MonYV2FPT0WU
NCI-H1299 MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW4TWM2OD1{LkmzO|M3KM7:TR?= NF[1VXdUSU6JRWK=
PSN1 NHPpWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXjbWpKSzVyPUOuNFU4QDZizszN NYTze49WW0GQR1XS
JVM-3 NYXUW4hGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPuTWM2OD1|LkC2O|U3KM7:TR?= MmTWV2FPT0WU
D-502MG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjRZnNKSzVyPUOuNFcxOTlizszN M3zXVHNCVkeHUh?=
SCC-4 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXMTWM2OD1|LkC5Nlc3KM7:TR?= MnTYV2FPT0WU
GMS-10 NX3wdpVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTNwMEmzPFgh|ryP MlvpV2FPT0WU
A427 M13oZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK5VpJkUUN3ME2zMlExQDd|IN88US=> M{TCU3NCVkeHUh?=
NH-12 MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXxdVFKSzVyPUOuNVE1PTZizszN NYPYeYtwW0GQR1XS
KM12 NELKUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzhXnd7UUN3ME2zMlEzOjd|IN88US=> MmTnV2FPT0WU
GI-1 M13SXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTMTWM2OD1|LkG1NlU2KM7:TR?= MW\TRW5ITVJ?
TE-8 NUnmS4t[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLtd2NFUUN3ME2zMlE6OjNzIN88US=> MkTtV2FPT0WU
MKN1 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzvTWM2OD1|LkKwPFc2KM7:TR?= Mk\1V2FPT0WU
NCI-H810 NH3UWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXKTWM2OD1|LkKyNVU2KM7:TR?= NYfDWoJFW0GQR1XS
GOTO NUPjbnl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYSxeI1xUUN3ME2zMlI5ODB2IN88US=> Mn\vV2FPT0WU
T98G NFXBcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1njWmlEPTB;Mz6yPFIyPiEQvF2= NWXPd3dkW0GQR1XS
HD-MY-Z M4DGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTNwM{[1OFIh|ryP M4\p[nNCVkeHUh?=
SNU-C2B NH\UbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHHTWM2OD1|LkO5NFk4KM7:TR?= MXHTRW5ITVJ?
MOLT-4 MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNwM{mwPVgh|ryP Ml;uV2FPT0WU
RPMI-7951 NGHzVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHGdmpsUUN3ME2zMlM6PzNizszN MoflV2FPT0WU
EW-11 M3PreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\V[WlKSzVyPUOuOFEzOjRizszN NYPh[pV6W0GQR1XS
RD NVTN[YZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDqTWM2OD1|LkSzNVMzKM7:TR?= NV3aUY1ZW0GQR1XS
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BB65-RCC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\qV3QxUUN3ME2zMlQ2Ozl4IN88US=> MneyV2FPT0WU
Ca-Ski M1Tibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPFTWM2OD1|LkS3OVE1KM7:TR?= NHm1WoRUSU6JRWK=
CHP-134 M33GPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrme5luUUN3ME2zMlQ5PzV6IN88US=> NE\ye4lUSU6JRWK=
CAL-33 NH7IZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTQTWM2OD1|LkWzN|YzKM7:TR?= NIC5PJNUSU6JRWK=
TYK-nu M4nLXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LwfWlEPTB;Mz61N|Y4PiEQvF2= NVS4blVvW0GQR1XS
LB831-BLC NGH2VJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;adWlEPTB;Mz61OFAyPiEQvF2= M{\JdHNCVkeHUh?=
KU-19-19 MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\3c2lEPTB;Mz62NFMxPCEQvF2= MVnTRW5ITVJ?
KG-1 MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTNwNkGxNFYh|ryP NYLtN3JHW0GQR1XS
COLO-829 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX6WHdHUUN3ME2zMlY3PjF6IN88US=> NEW2cJdUSU6JRWK=
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LB2241-RCC M4HHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPOTWM2OD1|Lk[4OlI2KM7:TR?= NULPN5RKW0GQR1XS
JEG-3 NWeyWZc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOyTWM2OD1|Lk[5NVkh|ryP Mo\tV2FPT0WU
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SK-MES-1 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTNwN{OwN{DPxE1? MljiV2FPT0WU
GT3TKB MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrnPZZjUUN3ME2zMlc2PjB2IN88US=> MkXoV2FPT0WU
DOK NEfmOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPIVYRKSzVyPUOuO|Y2OjZizszN MlrvV2FPT0WU
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8305C MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLUeo9{UUN3ME2zMlg5QTR|IN88US=> M1TSbXNCVkeHUh?=
CGTH-W-1 NXT4UopnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\wN4JRUUN3ME2zMlk{PTB2IN88US=> NWPkRno{W0GQR1XS
LU-134-A MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\wTWM2OD1|Lkm1OFIzKM7:TR?= MWXTRW5ITVJ?
C32 NEj0ZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH63d|hKSzVyPUOuPVY2QDFizszN MXTTRW5ITVJ?
MOLT-13 NYjXT3d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLWTWM2OD1|Lkm2PFU3KM7:TR?= Mln4V2FPT0WU
A375 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTRwMEWxOlIh|ryP NF\6WZVUSU6JRWK=
CAL-12T MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\PXGlEPTB;ND6wOVc6PSEQvF2= Mk[3V2FPT0WU
IGR-1 NI\0VXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHqTWM2OD12LkGwNlc1KM7:TR?= M1PNPHNCVkeHUh?=
LB1047-RCC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTRwMUC0OFEh|ryP MoW5V2FPT0WU
BHT-101 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnlTWM2OD12LkGwOlg{KM7:TR?= MWfTRW5ITVJ?
A431 NGfab5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LsR2lEPTB;ND6xOFA5OSEQvF2= NXLyOZBCW0GQR1XS
EPLC-272H NYm5foZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7se5ZKSzVyPUSuNVc2QTZizszN MUPTRW5ITVJ?
HT-1376 NIDReFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnEcIN1UUN3ME20MlI{ODV7IN88US=> MYPTRW5ITVJ?
HCC1954 NYrIdplnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTRwMkW3OFYh|ryP MXfTRW5ITVJ?
KYSE-510 MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmixTWM2OD12LkK2NFkh|ryP MX;TRW5ITVJ?
PANC-03-27 NWrFTGJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\XN5NVUUN3ME20MlMxODh|IN88US=> M3u0UHNCVkeHUh?=
MDA-MB-157 M3rj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3HTGRKSzVyPUSuN|A3PTZizszN NGjoUoVUSU6JRWK=
HOP-62 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXRTWM2OD12LkOwPFU3KM7:TR?= M1vvfHNCVkeHUh?=
ETK-1 M4jzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rDVGlEPTB;ND6zOlIxOyEQvF2= NFX1WGhUSU6JRWK=
MIA-PaCa-2 Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTRwM{[yNlch|ryP M1nCbHNCVkeHUh?=
MHH-PREB-1 M4HSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3VbIJKSzVyPUSuN|k4PzNizszN NVjlO2lWW0GQR1XS
LXF-289 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP1RWZrUUN3ME20MlQxOjB{IN88US=> NHfjR2tUSU6JRWK=
ATN-1 NYrmcIo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D5TWlEPTB;ND60NlM1OSEQvF2= NFyyTGtUSU6JRWK=
8505C NHHwcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrITWM2OD12LkS1PFI2KM7:TR?= NXqwW21EW0GQR1XS
HOS MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRwNE[0OVMh|ryP MlTVV2FPT0WU
U-266 MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDjTWM2OD12Lk[xNFMzKM7:TR?= M4LZeHNCVkeHUh?=
5637 MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Xjc2lEPTB;ND62NVQ1PCEQvF2= NH63fFJUSU6JRWK=
GCIY NWTJdFFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWG0WotLUUN3ME20MlcyODF3IN88US=> NYPzRYVyW0GQR1XS
MDA-MB-231 NHnJRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTRwN{KxNVUh|ryP MUTTRW5ITVJ?
RKO NFviO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HlfmlEPTB;ND63NlgyPyEQvF2= NIX1UHJUSU6JRWK=
COR-L23 M1vEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT4Rm9QUUN3ME20Mlc1OjV4IN88US=> Mn3KV2FPT0WU
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D-423MG NWPx[FRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfLT5h3UUN3ME20MlgxQDB|IN88US=> M{PzWHNCVkeHUh?=
DMS-114 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XXRmlEPTB;ND64NVM5PiEQvF2= MX7TRW5ITVJ?
MHH-ES-1 NIjNNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXBTWM2OD12LkiyOVA1KM7:TR?= MmjYV2FPT0WU
CAL-51 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTRwOE[4OFMh|ryP MlPKV2FPT0WU
SW626 MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17pZ2lEPTB;ND64PVY6PyEQvF2= NXzWNlFlW0GQR1XS
COLO-824 NUHJT3pGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwOUC0NFgh|ryP MUXTRW5ITVJ?
NCI-H1437 MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu0[3FKSzVyPUSuPVI6OyEQvF2= MoHyV2FPT0WU
CAL-39 NIfCe3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;yTWM2OD12LkmzPVg5KM7:TR?= NEK5XZdUSU6JRWK=
PC-3 NEHhVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTRwOUS2OFgh|ryP NUjacIVGW0GQR1XS
A101D NH7ucFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK0eGt[UUN3ME20Mlk3QDZ3IN88US=> NWP5[mVSW0GQR1XS
ES1 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4iwRWlEPTB;NT6wNFE{KM7:TR?= MnTaV2FPT0WU
TE-1 NWCzXGd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjnd41KSzVyPUWuNFM3PjZizszN M4LPe3NCVkeHUh?=
KP-N-YN NHyzPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPUTWM2OD13LkC1Olch|ryP NF\vPZBUSU6JRWK=
EFO-27 Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\vU2lEPTB;NT6wOlMzQSEQvF2= MXrTRW5ITVJ?
BT-549 M{\tNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfzTWM2OD13LkC3O|M3KM7:TR?= MWfTRW5ITVJ?
HLE M1vpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnmdlZKSzVyPUWuNVE4OzRizszN NEnHTW5USU6JRWK=
SW982 MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDk[YpKSzVyPUWuNVM{PzRizszN MkPuV2FPT0WU
SCC-25 M3XSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi3WIVYUUN3ME21MlE6ODR4IN88US=> NV;wXWVpW0GQR1XS
SK-MEL-28 NEToTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnq0TWM2OD13LkKwN|E{KM7:TR?= NF6xcoNUSU6JRWK=
CaR-1 NEfrU4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHl[pVFUUN3ME21MlIxPzJ4IN88US=> M3TzPXNCVkeHUh?=
MLMA MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HEfGlEPTB;NT6yN|Q{PiEQvF2= NYnZfXlXW0GQR1XS
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KNS-42 NYfQ[4tkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjKSpY5UUN3ME21MlI3OTZizszN MXzTRW5ITVJ?
TK10 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE[3b|lKSzVyPUWuN|YxQDZizszN M{T0NHNCVkeHUh?=
MEG-01 NELHdXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInoRnpKSzVyPUWuN|YzPzRizszN M4Hj[3NCVkeHUh?=
DEL MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTmTWM2OD13LkO5NFI{KM7:TR?= MXXTRW5ITVJ?
SJRH30 NY\JVXNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13PT2lEPTB;NT6zPVIyOyEQvF2= M4Ty[nNCVkeHUh?=
SK-PN-DW M3P1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLITWM2OD13LkSzOVg6KM7:TR?= M2DSUHNCVkeHUh?=
TE-10 M3nLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HleGlEPTB;NT60OFg6OyEQvF2= NGTzW2hUSU6JRWK=
KNS-81-FD MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvrOlFKSzVyPUWuOVAxQTJizszN NXy5[JJrW0GQR1XS
BHY NHrVOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfrRZBKSzVyPUWuOVExPyEQvF2= MkTGV2FPT0WU
KYSE-270 M2PmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTVwNUO1N|Yh|ryP M{\WSHNCVkeHUh?=
NCI-H650 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTVwNUexNVQh|ryP NXnlZ3BwW0GQR1XS
L-363 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17aVGlEPTB;NT62PVQ4PiEQvF2= NVSzbWdUW0GQR1XS
TCCSUP NInlT49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\nNZgzUUN3ME21MlcyPzd6IN88US=> MV;TRW5ITVJ?
SCH MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTVwN{S3Olch|ryP MUHTRW5ITVJ?
HTC-C3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;xPGlEPTB;NT63O|Y1PCEQvF2= MoHGV2FPT0WU
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Hs-578-T NF3MZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPxcXpiUUN3ME21Mlg{PjB5IN88US=> MnvhV2FPT0WU
M14 M2rrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTVwOE[3NlYh|ryP MmPCV2FPT0WU
HT-144 NVv4SGN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK2fVJKSzVyPUWuPFY5OzJizszN MUDTRW5ITVJ?
CAL-54 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTVwOUOzNVQh|ryP M3Pjb3NCVkeHUh?=
T47D NXTiUGUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnztTWM2OD13Lkm2NVIh|ryP MW\TRW5ITVJ?
GB-1 NGTncoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1POVWlEPTB;Nj6wNlA3QCEQvF2= MkLPV2FPT0WU
HSC-2 M4XoOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7KTWM2OD14LkGyN|U{KM7:TR?= NV\0dplNW0GQR1XS
SiHa MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nRUWlEPTB;Nj6xOFA6PyEQvF2= M4TQbXNCVkeHUh?=
OMC-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHwTWM2OD14LkO1OFQyKM7:TR?= NYTXPYU5W0GQR1XS
HGC-27 M1TkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTZwM{W3PFYh|ryP MYHTRW5ITVJ?
FTC-133 NF7CTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DCOWlEPTB;Nj60OlU2OSEQvF2= M3PmbXNCVkeHUh?=
KS-1 NVrWOIZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLXTphMUUN3ME22MlUzOTR5IN88US=> NXLBV4dKW0GQR1XS
HT-1080 M4C4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\ONWlEPTB;Nj61OFA1OiEQvF2= NEjIOYxUSU6JRWK=
SKG-IIIa MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPMdVF6UUN3ME22MlU3OjZ|IN88US=> MlzjV2FPT0WU
OCUB-M MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\MTWM2OD14Lk[wO|ch|ryP M2TUW3NCVkeHUh?=
MDA-MB-175-VII NF7IUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTZwNkKwPUDPxE1? NGLZSFhUSU6JRWK=
BB30-HNC NFzXc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTZwNke0OFQh|ryP NFLsRVVUSU6JRWK=
D-542MG M1f1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH1blJKSzVyPU[uO|MxQSEQvF2= NFrWe|hUSU6JRWK=
NCI-H2405 M1HsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTZwN{S4OVUh|ryP MoDEV2FPT0WU
SW1573 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrCR29VUUN3ME22Mlc5OzF7IN88US=> MXnTRW5ITVJ?
NCI-SNU-1 NET1eHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m2UGlEPTB;Nj63PVAzOiEQvF2= NUXpSItVW0GQR1XS
RT-112 NYLTUoFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDYUlluUUN3ME22Mlc6PDZ|IN88US=> M{iz[XNCVkeHUh?=
COR-L88 NFf2TndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPzdHhKSzVyPU[uO|k4QTFizszN NFXn[YdUSU6JRWK=
SCC-9 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTZwOEK1OUDPxE1? M33zOXNCVkeHUh?=
U-87-MG MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTZwOEO4NlYh|ryP NI\qO5VUSU6JRWK=
Detroit562 M3Hjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTZwOEW5PVEh|ryP MmPuV2FPT0WU
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IGROV-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTZwOUK1PFMh|ryP MlPVV2FPT0WU
OVCAR-8 M2rXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonzTWM2OD14Lkm0NlI6KM7:TR?= MlWzV2FPT0WU
SNU-387 NGq0OI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LzcWlEPTB;Nj65PVUyPiEQvF2= MlPqV2FPT0WU
TGBC1TKB MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLmOpdmUUN3ME23MlE2Ojd5IN88US=> NFHwcFJUSU6JRWK=
NOS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTHTWM2OD15LkKwOFE2KM7:TR?= MofpV2FPT0WU
HEC-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fHdGlEPTB;Nz6yOVM5PyEQvF2= NIDPPFRUSU6JRWK=
GI-ME-N M1XTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG1TWM2OD15LkK5NVU5KM7:TR?= MmLEV2FPT0WU
KYSE-520 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTdwMkmyPUDPxE1? MYTTRW5ITVJ?
SNU-423 M4jadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTnTWM2OD15LkK5OFUzKM7:TR?= NVjQenZFW0GQR1XS
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SK-UT-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\Mb2lKSzVyPUeuOVQ5OjlizszN MWnTRW5ITVJ?
OVCAR-4 NXPUb2prT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHpdI5KSzVyPUeuOVUzPiEQvF2= NIrEWJRUSU6JRWK=
KYSE-450 MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CzPWlEPTB;Nz62N|c6OSEQvF2= NGflVnRUSU6JRWK=
RS4-11 M1T1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjQNGprUUN3ME23MlcxOTl4IN88US=> NF\ZXmpUSU6JRWK=
OVCAR-5 M1vaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnJTWl6UUN3ME23MlgzOzJ7IN88US=> NVXHN49SW0GQR1XS
K5 NUe0VHVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4KxNWlEPTB;Nz64O|QzKM7:TR?= MXjTRW5ITVJ?
786-0 NXexTlRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXEeYlFUUN3ME24MlA{ODl3IN88US=> NIThellUSU6JRWK=
NCI-H747 NIXl[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlv6TWM2OD16LkC0OFU4KM7:TR?= M1r6TXNCVkeHUh?=
CAL-27 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MleyTWM2OD16LkGyO|Ih|ryP MnXhV2FPT0WU
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NCI-H2087 M1zHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DjNGlEPTB;OD6zOlE2QCEQvF2= NESwZ2dUSU6JRWK=
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MEL-JUSO NGHSXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPLT3BIUUN3ME24MlY5Pjd3IN88US=> MoDmV2FPT0WU
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NCI-H28 NWe0ZllET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[xOoN3UUN3ME24Mlg2OTh3IN88US=> MV;TRW5ITVJ?
C8166 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1freWlEPTB;OD64Olc4OiEQvF2= NWDUVI1TW0GQR1XS
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RCM-1 NGDFb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUftV4I2UUN3ME24Mlk3PDh4IN88US=> NEjNS3RUSU6JRWK=
BT-474 Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\zbZdSUUN3ME24Mlk5QDd{IN88US=> MYrTRW5ITVJ?
TI-73 NIjkd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq3TIhKSzVyPUmuNFM1QTZizszN NFfnc|lUSU6JRWK=
ES3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTlwMEWxOVYh|ryP NEfqU3VUSU6JRWK=
NB17 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTlwMUS1N|Uh|ryP MoKzV2FPT0WU
MOLT-16 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXxV5o1UUN3ME25MlE3PjV3IN88US=> NFmwe5ZUSU6JRWK=
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HuCCT1 M1myRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTlwNEe0NFYh|ryP NHvEU45USU6JRWK=
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A204 NGjHbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTlwOEm3OVUh|ryP NG\CV5dUSU6JRWK=
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PFSK-1 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnXTWM2OD17Lkm1OlY6KM7:TR?= MWPTRW5ITVJ?
KYSE-410 NYPBcoZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjTTWM2OD1zMD6wOlE2KM7:TR?= MXfTRW5ITVJ?
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NB5 M4PLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPBU3B6UUN3ME2xNE42PDB3IN88US=> MkP2V2FPT0WU
NTERA-S-cl-D1 M1LENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfNTWM2OD1zMD61OFc2KM7:TR?= NEXSR2JUSU6JRWK=
MZ2-MEL NUjWdYU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS1TYhPUUN3ME2xNE43PjJizszN Ml;3V2FPT0WU
SF539 NXm1cngxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1v6b2lEPTB;MUCuO|E5QCEQvF2= M{KzXHNCVkeHUh?=
CAL-120 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFyLke1PVch|ryP MnHiV2FPT0WU
GR-ST MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;1UItKSzVyPUGxMlI6QCEQvF2= NWPqeI1KW0GQR1XS
IA-LM MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG0eFFKSzVyPUGxMlM1QDZizszN NXTVe2FqW0GQR1XS
NCI-H2452 NVza[pI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvWbXVKSzVyPUGxMlM6OjdizszN NI\M[ldUSU6JRWK=
NCI-H1648 NHHiRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13ydmlEPTB;MUGuOFYzQSEQvF2= MY\TRW5ITVJ?
YH-13 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi0S25NUUN3ME2xNU41PzR{IN88US=> M3;rUHNCVkeHUh?=
NCI-H2228 NXXBR4R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFzLkS5Nlgh|ryP MVjTRW5ITVJ?
LN-405 NIHV[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7mfoxKSzVyPUGxMlU6OjdizszN MlW5V2FPT0WU
647-V MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XtXGlEPTB;MUGuOVk4PCEQvF2= NEnPSJdUSU6JRWK=
HCC1806 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTtTWM2OD1zMT62NVM1KM7:TR?= NHnlS|lUSU6JRWK=
HPAF-II MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfRTWM2OD1zMT64N|U3KM7:TR?= NHzMTnpUSU6JRWK=
BB49-HNC MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\vTWM2OD1zMT64N|c2KM7:TR?= MkfLV2FPT0WU
KGN MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTFzLki1PFkh|ryP NVPyTYE1W0GQR1XS
NOMO-1 NHPJZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HCS2lEPTB;MUGuPFU6PyEQvF2= NHjUTZNUSU6JRWK=
A388 NFHTXppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFzLki4NFgh|ryP M3HHVnNCVkeHUh?=
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SK-HEP-1 NXXSVmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnjUno6UUN3ME2xNk4zPjF|IN88US=> NHe0RXBUSU6JRWK=
HCE-4 MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvFRnRJUUN3ME2xNk4zPjl7IN88US=> MXzTRW5ITVJ?
NCI-H1581 MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\6XWlEPTB;MUKuNlgyQSEQvF2= NHvjcndUSU6JRWK=
NCI-H23 NF7OblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF{LkOxNlUh|ryP NXn3dYFLW0GQR1XS
NCI-H596 NWewNYRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHURZJnUUN3ME2xNk41Pzl6IN88US=> MkjwV2FPT0WU
NB69 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fiSWlEPTB;MUKuO|U5PSEQvF2= MYTTRW5ITVJ?
ChaGo-K-1 NGrxNllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jLd2lEPTB;MUKuO|Y1QSEQvF2= MlLmV2FPT0WU
EFM-19 NYjwbFgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPaPWN1UUN3ME2xNk44PzF5IN88US=> NIX4ZYNUSU6JRWK=
SW962 Ml:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTOTWM2OD1zMj64NlI{KM7:TR?= MnzvV2FPT0WU
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SW684 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13MVGlEPTB;MUOuNVg3OSEQvF2= NIrHOWFUSU6JRWK=
NCI-H2052 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3u3dmlEPTB;MUOuN|g1QCEQvF2= MoHDV2FPT0WU
HOP-92 NH:zRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF|Lke5PVch|ryP MVTTRW5ITVJ?
OE19 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF2LkCwO|Uh|ryP M3;Rd3NCVkeHUh?=
D-392MG MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGwTJBKSzVyPUG0MlEzOTFizszN MomxV2FPT0WU
A253 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX31Z4dRUUN3ME2xOE4zOjVizszN MnPxV2FPT0WU
NCI-H1155 NH\xbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGP4TYVKSzVyPUG0MlI4PDdizszN M1nV[3NCVkeHUh?=
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Calu-3 NIHnV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XHTWlEPTB;MUSuPFc1OyEQvF2= MXPTRW5ITVJ?
CW-2 M1q4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTF3LkCyNlMh|ryP M4DYb3NCVkeHUh?=
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NCI-SNU-5 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H4OWlEPTB;MUWuOVU5QSEQvF2= NIHLbGhUSU6JRWK=
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SF126 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLZTWM2OD1zNT63Nlg2KM7:TR?= MV3TRW5ITVJ?
D-247MG M4j2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmiyTWM2OD1zNT64OVM{KM7:TR?= NWj4dpNWW0GQR1XS
UACC-62 M{HiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF3Lkm2OkDPxE1? MmfvV2FPT0WU
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NCI-H1092 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTKXJFQUUN3ME2xOk43Ojl5IN88US=> NYLrW2ROW0GQR1XS
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G-402 M{DFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\XUINbUUN3ME2xOk45PTZ3IN88US=> MX3TRW5ITVJ?
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NCI-H2009 NGizT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzhTWM2OD1zNj65NlY3KM7:TR?= NUGwXGs3W0GQR1XS
SH-4 M4fTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfJUHNCUUN3ME2xOk46QTJizszN NUjOVWFwW0GQR1XS
SW1783 NGXseIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF4Lkm5PVgh|ryP MoOyV2FPT0WU
HT M3HVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTFT2t5UUN3ME2xO{4yQTZ2IN88US=> MnPLV2FPT0WU
CP66-MEL MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF5LkOwNUDPxE1? M3\1cXNCVkeHUh?=
BEN M1;GPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLUR|VRUUN3ME2xO{42PjJ4IN88US=> M3LyT3NCVkeHUh?=
HCC38 NET0RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF5Lke2PVgh|ryP MYfTRW5ITVJ?
LAN-6 NITtfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M171NmlEPTB;MUeuPFQ5PSEQvF2= MWrTRW5ITVJ?
RERF-LC-MS M13TVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVy1NWQyUUN3ME2xO{46OTJ7IN88US=> Mn7KV2FPT0WU
NCI-H1770 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTF5Lkm0PVEh|ryP NF7WXXpUSU6JRWK=
LCLC-103H NYDIOngzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF6LkC1NUDPxE1? MXjTRW5ITVJ?
NCI-H520 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF6LkOyPFEh|ryP M132OHNCVkeHUh?=
LU-65 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF6LkSwOFMh|ryP MkmxV2FPT0WU
SK-MEL-3 MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLQTWM2OD1zOD62Olc6KM7:TR?= NITQe4hUSU6JRWK=
LK-2 M{TQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjtWmhKSzVyPUG4Mlc4OjNizszN NIOwR4NUSU6JRWK=
PANC-08-13 M3XCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonVTWM2OD1zOD63PFg6KM7:TR?= MV\TRW5ITVJ?
NCI-H460 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXuTWM2OD1zOD64OFY3KM7:TR?= MkO1V2FPT0WU
COLO-684 NIHjT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3sTWM2OD1zOD65PVU3KM7:TR?= M2[3[nNCVkeHUh?=
RPMI-2650 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzPTWM2OD1zOT6wNVIh|ryP NHn4emRUSU6JRWK=
NY NFHJb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTkSIxKSzVyPUG5MlE2PjdizszN MVvTRW5ITVJ?
NB7 M2nwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETUeohKSzVyPUG5MlE4PTNizszN NHXxUZhUSU6JRWK=
NCI-H358 M{m0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LYO2lEPTB;MUmuNlY4OyEQvF2= NHX4O2tUSU6JRWK=
MC116 M2\xcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\pNmlEPTB;MUmuOVM{OSEQvF2= NWTC[YloW0GQR1XS
MS-1 NH\r[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDuXFhKUUN3ME2xPU43OTB|IN88US=> NVfxeJR7W0GQR1XS
NCI-H82 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnJTWM2OD1zOT62PFc5KM7:TR?= Mnz6V2FPT0WU
OCI-AML2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTF7LkewN|Ih|ryP MWjTRW5ITVJ?
LS-123 NGWzTGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVW5fpNvUUN3ME2yNE4xOTl2IN88US=> MWfTRW5ITVJ?
PC-14 NVnafFRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nD[2lEPTB;MkCuNVg{PCEQvF2= MnTUV2FPT0WU
NCI-H1703 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTJyLkixO|Mh|ryP M3vScXNCVkeHUh?=
Calu-6 M3zvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTPfXJqUUN3ME2yNU4yODB3IN88US=> MVTTRW5ITVJ?
no-11 NH;PdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJzLkG2NFIh|ryP MlTiV2FPT0WU
NCI-H727 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jGfWlEPTB;MkGuN|Q6OyEQvF2= M3\hPHNCVkeHUh?=
DSH1 MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHaNWZXUUN3ME2yNU4{QDd7IN88US=> M13MTnNCVkeHUh?=
KYSE-140 Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mki4TWM2OD1{MT63NlcyKM7:TR?= MUXTRW5ITVJ?
RH-1 MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXq[FFEUUN3ME2yNU45QDNizszN NYP6UINvW0GQR1XS
HAL-01 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJ{LkC0NVgh|ryP MYPTRW5ITVJ?
RXF393 NWn3b|R[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPXRZhqUUN3ME2yNk4zPzh7IN88US=> NIfKXnZUSU6JRWK=
LS-411N M4DVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPud5lKSzVyPUKyMlI5PjlizszN NVTEWGltW0GQR1XS
no-10 NFjKWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M320b2lEPTB;MkKuOVAxPCEQvF2= NX;OT|JjW0GQR1XS
MKN7 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq0TWM2OD1{Mj62PFch|ryP MYrTRW5ITVJ?
AU565 NUXBRXVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrTdodKSzVyPUKyMlc1PzhizszN MoH5V2FPT0WU
NUGC-3 NFniclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzIOpNKSzVyPUKzMlEyQTlizszN M3mxc3NCVkeHUh?=
EW-16 Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH4TZRKSzVyPUK0MlA6OjZizszN MXnTRW5ITVJ?
HCC70 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TGT2lEPTB;MkSuNVMzOyEQvF2= NGTlSpdUSU6JRWK=
RPMI-8226 M{TYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz6fYtKSzVyPUK0MlMyPTVizszN MVPTRW5ITVJ?
CFPAC-1 Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rnfGlEPTB;MkSuOlI4OiEQvF2= M{XTVXNCVkeHUh?=
DoTc2-4510 M{jG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnmTmg2UUN3ME2yOE44PTd3IN88US=> NYHubWp[W0GQR1XS
KNS-62 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr3b|lKSzVyPUK1MlAyQCEQvF2= NYq3b4tmW0GQR1XS
SK-N-DZ M4r3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfhTWM2OD1{NT6wPVA1KM7:TR?= NW\TcVg3W0GQR1XS
CAL-85-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDzNnBkUUN3ME2yOU4yPTR2IN88US=> M4jTXnNCVkeHUh?=
JVM-2 M1\EXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUG2cohqUUN3ME2yOU4zOTJ{IN88US=> M{POVXNCVkeHUh?=
NCI-H2347 NVXIO|BuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zYXmlEPTB;MkWuOFI1QSEQvF2= NHPwRZdUSU6JRWK=
P30-OHK M2H5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnHb|B[UUN3ME2yOU43OzF6IN88US=> NUnMPWM{W0GQR1XS
SK-N-FI NXPRUVQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WzUWlEPTB;Mk[uNVE3OiEQvF2= M{nTcnNCVkeHUh?=
CAMA-1 NFvlVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon1TWM2OD1{Nj60PFc3KM7:TR?= M{m4XHNCVkeHUh?=
MHH-NB-11 M2LoSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPXOXV7UUN3ME2yOk42QDVzIN88US=> MljrV2FPT0WU
IST-MEL1 M3S4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv0TWM2OD1{Nj63NVc4KM7:TR?= NV7sdoU5W0GQR1XS
KARPAS-299 NHfFUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ5LkS3NFEh|ryP NWryW2U6W0GQR1XS
TE-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTJ5LkezOFIh|ryP MUjTRW5ITVJ?
769-P MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTLOFQ2UUN3ME2yPE41PTN|IN88US=> NHPJU5hUSU6JRWK=
CAL-72 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJ6LkW1OlEh|ryP NVTseGhUW0GQR1XS
NCI-H2342 MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;0TWM2OD1{OT6zPFA{KM7:TR?= MYLTRW5ITVJ?
NCI-H1651 M1vaRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq0TWM2OD1{OT64OVA{KM7:TR?= NUj2bVBiW0GQR1XS
OE33 M{fqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;5XWlEPTB;M{CuNVM1OiEQvF2= NEHIO3JUSU6JRWK=
HuP-T4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvjPGdyUUN3ME2zNU41QDN5IN88US=> MWnTRW5ITVJ?
U-118-MG M2PIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLTUIttUUN3ME2zNk42PDRzIN88US=> Ml\yV2FPT0WU
SN12C MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vhNmlEPTB;M{KuPFgyPSEQvF2= NIHvfnpUSU6JRWK=
TE-5 M{Pvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3RTWM2OD1|Mz6xN|Y5KM7:TR?= MojxV2FPT0WU
KM-H2 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW2fYpvUUN3ME2zN{4yPjl7IN88US=> NVrzbHZkW0GQR1XS
OVCAR-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTN|LkSxNlch|ryP NFvZZVVUSU6JRWK=
NCI-H1304 NWnZNY1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYeyU5BSUUN3ME2zN{43ODN4IN88US=> MkXOV2FPT0WU
LU-135 NIXwfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\oZ|E{UUN3ME2zN{44ODh4IN88US=> NIq0dW1USU6JRWK=
S-117 NV7KXJQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTN|LkeyPFYh|ryP NXGy[FR{W0GQR1XS
NCI-H1755 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHpeoNlUUN3ME2zN{45OTFizszN NHfiT5JUSU6JRWK=
Mo-T NEfDN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7HVHhKSzVyPUOzMlg2QTNizszN NV3qZ|BDW0GQR1XS
SK-OV-3 MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vNNWlEPTB;M{OuPFg2PCEQvF2= NFH5S4pUSU6JRWK=
RCC10RGB NFXmUIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLwTWM2OD1|Mz65OFM{KM7:TR?= MoWwV2FPT0WU
COLO-680N MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETCUoZKSzVyPUO0MlE{QTdizszN NUfPdW5NW0GQR1XS
KURAMOCHI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fTe2lEPTB;M{SuOlQzPSEQvF2= NG\KSodUSU6JRWK=
NCI-H661 M3vpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkD3TWM2OD1|ND64OFQ5KM7:TR?= MXLTRW5ITVJ?
YAPC NIjEcoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDpTWM2OD1|NT65OVM{KM7:TR?= NXzYWmo4W0GQR1XS
NCI-H526 NGPv[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN5LkK3O|Ih|ryP M3qzPHNCVkeHUh?=
A498 NH7CR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fBW2lEPTB;M{iuNFk2PCEQvF2= NYnXd5F7W0GQR1XS
VMRC-RCZ MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFflbYtKSzVyPUO5MlAxPTRizszN MVnTRW5ITVJ?
HCT-116 NX7TemllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPSeIFKSzVyPUO5MlA2QCEQvF2= MXHTRW5ITVJ?
COLO-320-HSR MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXKe4YyUUN3ME20NE4xPDFizszN MmnVV2FPT0WU
OAW-42 NXyyS4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTRyLkC1OFIh|ryP M3Tte3NCVkeHUh?=
SK-MEL-1 NVrLWpFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H4cWlEPTB;NECuNlkzPyEQvF2= M3;HVnNCVkeHUh?=
IST-MES1 NVjLfZJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPmTWM2OD12MD63OlU{KM7:TR?= NF;T[WFUSU6JRWK=
CP50-MEL-B MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTRzLkC3PVch|ryP M3u3RnNCVkeHUh?=
RMG-I MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzHTWM2OD12Mj60PVIyKM7:TR?= MlX3V2FPT0WU
D-336MG NGTydXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWxb4xKSzVyPUSzMlEyPTJizszN M2eyZnNCVkeHUh?=
SHP-77 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn4XXJ2UUN3ME20N{4yQDJ6IN88US=> Ml;aV2FPT0WU
SW872 NYXYRWJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37iZWlEPTB;NEOuNlEzOyEQvF2= MYfTRW5ITVJ?
DBTRG-05MG MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHNTWM2OD12ND62PVk3KM7:TR?= MYrTRW5ITVJ?
COLO-678 MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnObIZQUUN3ME20OU44ODN{IN88US=> NUjYSpZyW0GQR1XS
EGI-1 NHXCe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTR5LkG4N|Mh|ryP M1LYOHNCVkeHUh?=
KYSE-70 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWWyTJkyUUN3ME20O{44OjJ{IN88US=> NF;0UJFUSU6JRWK=
BALL-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTR5LkiyOVQh|ryP MWPTRW5ITVJ?
MDA-MB-361 NEnXR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjU[G5SUUN3ME20PE4xPDZizszN MofLV2FPT0WU
NCI-H1838 NV7PPHpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHHSZExUUN3ME20PE4{PDV6IN88US=> NGC1[IJUSU6JRWK=
NCI-H1573 MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjQTWM2OD12OD62O|g2KM7:TR?= MVTTRW5ITVJ?
HCC1395 M2rvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[4OYFbUUN3ME20PE46QTJizszN M2TuZnNCVkeHUh?=
NCI-H2291 NWXhT5B4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LIcWlEPTB;NEmuOVk5QCEQvF2= NX\CeXJYW0GQR1XS
RH-18 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXYTWM2OD13MD6wPFg1KM7:TR?= MmjFV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

17040210 28415756 25395420
Immunofluorescence
PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

25002506
Growth inhibition assay
Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

28415756

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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