BI-D1870

For research use only.

Catalog No.S2843

21 publications

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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Selleck's BI-D1870 has been cited by 21 publications

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NX3JOJIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ISGRLUUN3ME2wMlA{PThizszN MUnTRW5ITVJ?
H9 MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIO2T2RKSzVyPUCuNFYxOTlizszN M1mwSXNCVkeHUh?=
KARPAS-45 NVT6e3JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[3XGlEPTB;MD6xOlUzPSEQvF2= MkjnV2FPT0WU
NCI-H720 M17wT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTMSWtWUUN3ME2wMlE4OTl2IN88US=> M16xSnNCVkeHUh?=
CTV-1 M4jVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf1U457UUN3ME2wMlQ4QDd{IN88US=> NUDl[WNkW0GQR1XS
DU-4475 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwNUC0NVch|ryP M3\wVXNCVkeHUh?=
A172 M4nMdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG1WHlKSzVyPUCuOVE4ODVizszN NIPr[|dUSU6JRWK=
EW-18 NFG5UGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwNkKyNVEh|ryP MYTTRW5ITVJ?
KU812 NGK5PHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnqNW5rUUN3ME2wMlYzPjJ|IN88US=> NHLpcI5USU6JRWK=
KP-N-YS MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G0fGlEPTB;MD62PFIzOyEQvF2= MWTTRW5ITVJ?
SBC-1 NYLzXplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTzeppKSzVyPUCuOlk2OjRizszN MWTTRW5ITVJ?
ECC10 NE\QdVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGeyOY1KSzVyPUCuO|AxQTRizszN M3;3OnNCVkeHUh?=
GAMG NUnP[lRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwN{S3NVch|ryP M3PBdHNCVkeHUh?=
NCI-H209 NYrqTHpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjkT5VtUUN3ME2wMlc3QDJizszN MVzTRW5ITVJ?
MC-IXC M1PYR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGGwdmVKSzVyPUCuO|k2QDlizszN MWHTRW5ITVJ?
HSC-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDETWM2OD1yLkixO|Y6KM7:TR?= M4DORnNCVkeHUh?=
IST-SL1 M1TKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwOES1O|Qh|ryP M4HjcXNCVkeHUh?=
LU-139 NGG1SXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwOES5OVgh|ryP NEXKVHRUSU6JRWK=
ML-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zafmlEPTB;MD64OVU4PSEQvF2= NWW2RoE3W0GQR1XS
CAL-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHGTWM2OD1yLki4NVUzKM7:TR?= NXrkXGpHW0GQR1XS
HL-60 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfCSXFoUUN3ME2wMlg5OzZ{IN88US=> NWLQXZFZW0GQR1XS
KY821 MkHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwOEi4NVIh|ryP MYHTRW5ITVJ?
ES7 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwOUG2NFch|ryP MXLTRW5ITVJ?
MV-4-11 M2\4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwOUe4PVch|ryP MkXkV2FPT0WU
Daoy NYfZemU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPG[|FTUUN3ME2wMlk5PzZ5IN88US=> MmSyV2FPT0WU
EoL-1-cell NHriPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGe5cIFKSzVyPUGuNFE5PzhizszN M2TY[XNCVkeHUh?=
TGW M1TqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;mTWM2OD1zLkC1NVI1KM7:TR?= M3LaZXNCVkeHUh?=
LAMA-84 M4HXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1WxR2lEPTB;MT6xNlc6PCEQvF2= NEDvNodUSU6JRWK=
KOSC-2 NXToOXgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnm3TWM2OD1zLkGzN|g2KM7:TR?= M3HwWXNCVkeHUh?=
A549 M2XBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwM{C5OVUh|ryP NIn1c21USU6JRWK=
CTB-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjHTWM2OD1zLkS0Olc6KM7:TR?= MU\TRW5ITVJ?
NCI-H292 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PIOGlEPTB;MT60OlA3QSEQvF2= MYLTRW5ITVJ?
LoVo NXvTU|NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPwTWM2OD1zLkS2O|U2KM7:TR?= MoLHV2FPT0WU
BFTC-905 NXK4OW9GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjVbWlKSzVyPUGuOVY{OzJizszN MWPTRW5ITVJ?
BE-13 NVfGcoZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTmNZBXUUN3ME2xMlU5PzB7IN88US=> M2rOSXNCVkeHUh?=
KE-37 NWHlWldCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf0fGZKSzVyPUGuOVk1PzhizszN M4PPfXNCVkeHUh?=
HN NIrvOWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXHZ|NzUUN3ME2xMlYyOzZ6IN88US=> M2[yO3NCVkeHUh?=
A3-KAW M1vjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2flUGlEPTB;MT62Nlg{PCEQvF2= MlmwV2FPT0WU
NEC8 NG\ncphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXvTWM2OD1zLkewNVE2KM7:TR?= MW\TRW5ITVJ?
Ramos-2G6-4C10 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoCyTWM2OD1zLkewOFQ1KM7:TR?= MkPXV2FPT0WU
NB10 NFfnTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFwN{e2N{DPxE1? MmHiV2FPT0WU
NBsusSR NUCxTVhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rFPWlEPTB;MT64Nlk3OSEQvF2= M1exS3NCVkeHUh?=
ES4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3aTWM2OD1zLki1NVQ{KM7:TR?= M1Ta[XNCVkeHUh?=
ES8 NXLpZpoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHvTWM2OD1zLki3O|I1KM7:TR?= NYCwc2dwW0GQR1XS
CHL-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwOUW3PVIh|ryP NHi1b5lUSU6JRWK=
NCI-H2029 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvPcoRKSzVyPUGuPVczPDFizszN NF[3OIxUSU6JRWK=
YKG-1 M2\yfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfPTWM2OD1zLkm4OFMzKM7:TR?= NFH4UItUSU6JRWK=
BV-173 M4fIfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzEOFl3UUN3ME2xMlk5PjZ4IN88US=> NUexN3Z4W0GQR1XS
697 Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TkSGlEPTB;Mj6wNlIzQCEQvF2= M3zDfXNCVkeHUh?=
SK-NEP-1 MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3LRpRbUUN3ME2yMlA1PCEQvF2= MmDDV2FPT0WU
LOXIMVI MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJwMES0N|Qh|ryP MXrTRW5ITVJ?
QIMR-WIL NFe5Z|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPZUZhKSzVyPUKuNFc5PDlizszN NYnBV41rW0GQR1XS
DU-145 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVmwcW9YUUN3ME2yMlEyODV4IN88US=> NEXzNpJUSU6JRWK=
NB14 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnITYpKSzVyPUKuNVE{OjFizszN NXzlcXQ5W0GQR1XS
G-361 NHHQdIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4W4OWlEPTB;Mj6xNlIyKM7:TR?= M4TQSnNCVkeHUh?=
BPH-1 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJwMUK5OVch|ryP MUHTRW5ITVJ?
KYSE-150 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Moq1TWM2OD1{LkG1NlM1KM7:TR?= NFjqSY9USU6JRWK=
HMV-II M4Xz[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3T1d2lEPTB;Mj6xOlY{OyEQvF2= MVvTRW5ITVJ?
TE-9 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYq1UHVMUUN3ME2yMlE4Ozd4IN88US=> MXnTRW5ITVJ?
8-MG-BA M3nUdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJwMkO0OlEh|ryP MnW0V2FPT0WU
ES5 Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwMkO2N|Mh|ryP MVzTRW5ITVJ?
D-283MED NFjlVmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK1TWM2OD1{LkKzOlk2KM7:TR?= MkjFV2FPT0WU
SK-N-AS MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvPSG9JUUN3ME2yMlI6ODV7IN88US=> M1;Y[3NCVkeHUh?=
SW1710 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\sWJg5UUN3ME2yMlMxPjZzIN88US=> MYrTRW5ITVJ?
GCT NXHWelV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJwM{GzOVgh|ryP MonuV2FPT0WU
AGS NH71NJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LsdWlEPTB;Mj6zOFQxPCEQvF2= MXTTRW5ITVJ?
HuO9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PzV2lEPTB;Mj6zOlgzPCEQvF2= NFnKVY1USU6JRWK=
MN-60 M374dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFj0[FBKSzVyPUKuOFQ5QDNizszN NUH6dY5FW0GQR1XS
NB6 NYHqVI9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnm[XJKSzVyPUKuOFU4PzlizszN NWLidnU2W0GQR1XS
NCI-H1395 NEfZPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTJwNEexNlEh|ryP NFn3O5FUSU6JRWK=
H4 NIfhWndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHpUXNKSzVyPUKuOFg{QTNizszN NGG4VY5USU6JRWK=
HT-3 NV7zdJRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rjdWlEPTB;Mj61NVAzPCEQvF2= NWqwWWFrW0GQR1XS
P12-ICHIKAWA MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi1[JdsUUN3ME2yMlUzPTV7IN88US=> NUnWRVI4W0GQR1XS
COLO-800 NWXaSnd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO4TWM2OD1{LkW0NVY3KM7:TR?= Mne3V2FPT0WU
DB NXnPN5NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrHbJBKSzVyPUKuOVUxOTNizszN NFHCZWZUSU6JRWK=
LCLC-97TM1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WweWlEPTB;Mj62NFAzQCEQvF2= NXf2cG5JW0GQR1XS
Ca9-22 MnOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2noRWlEPTB;Mj62OVk{OyEQvF2= M1HPe3NCVkeHUh?=
Becker MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrQTWM2OD1{Lk[2NFc5KM7:TR?= NH72TYxUSU6JRWK=
ACN Mn3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jzbGlEPTB;Mj62Olc6KM7:TR?= NHjlPGZUSU6JRWK=
SJSA-1 NHG5[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknZTWM2OD1{Lk[2PFch|ryP M1u3WXNCVkeHUh?=
NCI-H1048 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLOfVBKUUN3ME2yMlY5OzJzIN88US=> MYDTRW5ITVJ?
HEL MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJwN{CyOVQh|ryP MonMV2FPT0WU
NCI-H69 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwN{G2NFEh|ryP M2nS[XNCVkeHUh?=
639-V MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjNenpNUUN3ME2yMlcyPzB|IN88US=> NGfpfHlUSU6JRWK=
U251 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrsSWM2UUN3ME2yMlc{ODN{IN88US=> MVvTRW5ITVJ?
NCI-H1792 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W3b2lEPTB;Mj63N|c{QCEQvF2= MUXTRW5ITVJ?
EW-1 M2THcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP2SGJKSzVyPUKuO|U{OjhizszN M{nPT3NCVkeHUh?=
ME-180 NHvqfZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnGTWM2OD1{Lke3O|M3KM7:TR?= MYDTRW5ITVJ?
HH NGjFOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoflTWM2OD1{LkiwNFAyKM7:TR?= M{TTb3NCVkeHUh?=
SW954 MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln2TWM2OD1{Lki1PFMh|ryP M2LKdXNCVkeHUh?=
SF268 NHfSPJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHXWpRKSzVyPUKuPFczOjVizszN M4HQO3NCVkeHUh?=
D-566MG Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT4NItCUUN3ME2yMlkyOjl3IN88US=> NULuV3lZW0GQR1XS
EM-2 M3XSWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTvTWM2OD1{LkmyNVk{KM7:TR?= NIXDZ2hUSU6JRWK=
NCI-H1299 NWG5R245T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvnTWM2OD1{LkmzO|M3KM7:TR?= MYrTRW5ITVJ?
PSN1 NGflfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHrPWFvUUN3ME2zMlA2Pzh4IN88US=> M2TMb3NCVkeHUh?=
JVM-3 MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq5T3NrUUN3ME2zMlA3PzV4IN88US=> M4HV[3NCVkeHUh?=
D-502MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\QbmlEPTB;Mz6wO|AyQSEQvF2= NWns[GFUW0GQR1XS
SCC-4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvpXWhJUUN3ME2zMlA6Ojd4IN88US=> NVXQW|JEW0GQR1XS
GMS-10 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT5e45NUUN3ME2zMlA6Ozh6IN88US=> NIHNSYZUSU6JRWK=
A427 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGL3N4FKSzVyPUOuNVA5PzNizszN NGXFZ41USU6JRWK=
NH-12 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TJc2lEPTB;Mz6xNVQ2PiEQvF2= NW\IV4RNW0GQR1XS
KM12 M2P4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LjW2lEPTB;Mz6xNlI4OyEQvF2= NHfUcolUSU6JRWK=
GI-1 NITmfnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTNwMUWyOVUh|ryP NXjmWmdsW0GQR1XS
TE-8 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L3e2lEPTB;Mz6xPVI{OSEQvF2= NISx[2VUSU6JRWK=
MKN1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTNwMkC4O|Uh|ryP M1S0RXNCVkeHUh?=
NCI-H810 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17FOmlEPTB;Mz6yNlE2PSEQvF2= NELDW5NUSU6JRWK=
GOTO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTNwMkiwNFQh|ryP NXXvVphCW0GQR1XS
T98G NHXoeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Ho[2lEPTB;Mz6yPFIyPiEQvF2= NYXnNoh7W0GQR1XS
HD-MY-Z NUDpPFYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz3NXRKSzVyPUOuN|Y2PDJizszN NEjrdJdUSU6JRWK=
SNU-C2B MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzhTWM2OD1|LkO5NFk4KM7:TR?= NGnyN|NUSU6JRWK=
MOLT-4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX1SXJtUUN3ME2zMlM6ODl6IN88US=> MX\TRW5ITVJ?
RPMI-7951 NXntSWc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNwM{m3N{DPxE1? NIf4S2RUSU6JRWK=
EW-11 M3TFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nGVmlEPTB;Mz60NVIzPCEQvF2= NEHySZdUSU6JRWK=
RD M4ezcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;KPXMzUUN3ME2zMlQ{OTN{IN88US=> MWTTRW5ITVJ?
SW48 NEDjOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z4[GlEPTB;Mz60N|M2QCEQvF2= M3jq[nNCVkeHUh?=
BB65-RCC MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPzc|JVUUN3ME2zMlQ2Ozl4IN88US=> MWPTRW5ITVJ?
Ca-Ski MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLLTWM2OD1|LkS3OVE1KM7:TR?= MnfoV2FPT0WU
CHP-134 MkXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHiTWM2OD1|LkS4O|U5KM7:TR?= MVPTRW5ITVJ?
CAL-33 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[4PZdKSzVyPUOuOVM{PjJizszN M{HZPXNCVkeHUh?=
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LB831-BLC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTNwNUSwNVYh|ryP M175UXNCVkeHUh?=
KU-19-19 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TPbGlEPTB;Mz62NFMxPCEQvF2= MXjTRW5ITVJ?
KG-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNwNkGxNFYh|ryP NX\vfFY4W0GQR1XS
COLO-829 M{DVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTNwNk[2NVgh|ryP NVnJZ45NW0GQR1XS
HUTU-80 NUnNOoRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTMTWM2OD1|Lk[2OlIyKM7:TR?= M1T0bXNCVkeHUh?=
NCI-H446 MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7BZ3VKSzVyPUOuOlg{PCEQvF2= M4TEU3NCVkeHUh?=
LB2241-RCC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fUfmlEPTB;Mz62PFYzPSEQvF2= NF\mPXRUSU6JRWK=
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LNCaP-Clone-FGC Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTKN|lwUUN3ME2zMlcxODRzIN88US=> MkG1V2FPT0WU
M059J M1fUR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTNwN{G0Olgh|ryP MofEV2FPT0WU
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HO-1-N-1 NHH1RmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLQUG9jUUN3ME2zMlc6QDBzIN88US=> M3LPbnNCVkeHUh?=
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C32 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDGeHpKUUN3ME2zMlk3PThzIN88US=> MWjTRW5ITVJ?
MOLT-13 NIm0NW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTWc3REUUN3ME2zMlk3QDV4IN88US=> Ml22V2FPT0WU
A375 NWjORlRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\UV5dFUUN3ME20MlA2OTZ{IN88US=> MWrTRW5ITVJ?
CAL-12T MmHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfaWHZKSzVyPUSuNFU4QTVizszN MVHTRW5ITVJ?
IGR-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTRwMUCyO|Qh|ryP MVXTRW5ITVJ?
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EPLC-272H NGjBZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi4RlQ4UUN3ME20MlE4PTl4IN88US=> M4[3W3NCVkeHUh?=
HT-1376 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjFTWM2OD12LkKzNFU6KM7:TR?= NGTMc|NUSU6JRWK=
HCC1954 MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\SU216UUN3ME20MlI2PzR4IN88US=> MXfTRW5ITVJ?
KYSE-510 NXjKeVBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnGVHZKSzVyPUSuNlYxQSEQvF2= NW[1RVlLW0GQR1XS
PANC-03-27 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWriVXhpUUN3ME20MlMxODh|IN88US=> MX3TRW5ITVJ?
MDA-MB-157 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX4Rm1oUUN3ME20MlMxPjV4IN88US=> NXzVXZVRW0GQR1XS
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ATN-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLwTWM2OD12LkSyN|QyKM7:TR?= MnHoV2FPT0WU
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U-266 NFK1NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;SZXBuUUN3ME20MlYyODN{IN88US=> MX\TRW5ITVJ?
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GCIY MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTZfWNCUUN3ME20MlcyODF3IN88US=> M3v6UXNCVkeHUh?=
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D-423MG MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K2[GlEPTB;ND64NFgxOyEQvF2= NGDnXYdUSU6JRWK=
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CAL-51 NV[4fIRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn5WJVKSzVyPUSuPFY5PDNizszN NGqxbFdUSU6JRWK=
SW626 M3vhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf0VY5kUUN3ME20Mlg6Pjl5IN88US=> MWPTRW5ITVJ?
COLO-824 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LrPWlEPTB;ND65NFQxQCEQvF2= MWPTRW5ITVJ?
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NCI-H460 NGHI[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTF6Lki0OlYh|ryP MYTTRW5ITVJ?
COLO-684 M3\Me2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGwcnpYUUN3ME2xPE46QTV4IN88US=> NVvzOndwW0GQR1XS
RPMI-2650 M1j6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXvNFJKSzVyPUG5MlAyOiEQvF2= NHr1NIZUSU6JRWK=
NY NEfidZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXoU4hKSzVyPUG5MlE2PjdizszN NVXWXFJVW0GQR1XS
NB7 M1T3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETqPGpKSzVyPUG5MlE4PTNizszN M{TTb3NCVkeHUh?=
NCI-H358 NFPN[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjHVYh4UUN3ME2xPU4zPjd|IN88US=> M1XTV3NCVkeHUh?=
MC116 NEm5XY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj0OWJKSzVyPUG5MlU{OzFizszN NHfMTJlUSU6JRWK=
MS-1 M3vLTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnwTWM2OD1zOT62NVA{KM7:TR?= Mn33V2FPT0WU
NCI-H82 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmi1TWM2OD1zOT62PFc5KM7:TR?= MYfTRW5ITVJ?
OCI-AML2 NI\OTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTF7LkewN|Ih|ryP Mo[4V2FPT0WU
LS-123 NEXHUVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfJSYZUUUN3ME2yNE4xOTl2IN88US=> NEPK[YpUSU6JRWK=
PC-14 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHaTWM2OD1{MD6xPFM1KM7:TR?= NH;HOWlUSU6JRWK=
NCI-H1703 M1zhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKxNnR5UUN3ME2yNE45OTd|IN88US=> MnTnV2FPT0WU
Calu-6 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXK4eJVCUUN3ME2yNU4yODB3IN88US=> MlzNV2FPT0WU
no-11 M1Pnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml23TWM2OD1{MT6xOlAzKM7:TR?= NHnON45USU6JRWK=
NCI-H727 NXfReo1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\WTWM2OD1{MT6zOFk{KM7:TR?= MlLhV2FPT0WU
DSH1 NEjOPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme0TWM2OD1{MT6zPFc6KM7:TR?= MlzIV2FPT0WU
KYSE-140 NHryRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\xWHJbUUN3ME2yNU44OjdzIN88US=> Mm\iV2FPT0WU
RH-1 M{nZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D4S2lEPTB;MkGuPFg{KM7:TR?= MorFV2FPT0WU
HAL-01 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jnWmlEPTB;MkKuNFQyQCEQvF2= NGnybGVUSU6JRWK=
RXF393 M1njPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[zfFFKSzVyPUKyMlI4QDlizszN NYTlfJRvW0GQR1XS
LS-411N NUfENldrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\4e4FKSzVyPUKyMlI5PjlizszN NYPne4w1W0GQR1XS
no-10 NVXQfnVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTNTWM2OD1{Mj61NFA1KM7:TR?= Mli0V2FPT0WU
MKN7 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJ{Lk[4O{DPxE1? NVzSNFNtW0GQR1XS
AU565 NGO0XYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ{Lke0O|gh|ryP M4\PXHNCVkeHUh?=
NUGC-3 MlmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HMSmlEPTB;MkOuNVE6QSEQvF2= MXvTRW5ITVJ?
EW-16 M2TCUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnkSWJKSzVyPUK0MlA6OjZizszN NFe1U5dUSU6JRWK=
HCC70 NUjjO3BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\CWGlEPTB;MkSuNVMzOyEQvF2= M2jlRXNCVkeHUh?=
RPMI-8226 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlv5TWM2OD1{ND6zNVU2KM7:TR?= NUfvW4drW0GQR1XS
CFPAC-1 NHv0ZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnLTWM2OD1{ND62NlczKM7:TR?= MXnTRW5ITVJ?
DoTc2-4510 M3;UTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDYWZAzUUN3ME2yOE44PTd3IN88US=> NGXueZdUSU6JRWK=
KNS-62 NXzjSoVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJ3LkCxPEDPxE1? MkLYV2FPT0WU
SK-N-DZ NUnNc2M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXVTWM2OD1{NT6wPVA1KM7:TR?= NWq1NoZDW0GQR1XS
CAL-85-1 NGrJ[JZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjVdGJKSzVyPUK1MlE2PDRizszN MnLhV2FPT0WU
JVM-2 M{XlT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmeyTWM2OD1{NT6yNVIzKM7:TR?= NX;sRoJxW0GQR1XS
NCI-H2347 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnxSIhMUUN3ME2yOU41OjR7IN88US=> NVfQeXdHW0GQR1XS
P30-OHK Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJ3Lk[zNVgh|ryP MWLTRW5ITVJ?
SK-N-FI M1z1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf1ZXNKSzVyPUK2MlEyPjJizszN M4HNb3NCVkeHUh?=
CAMA-1 NXfnVFBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPWTWM2OD1{Nj60PFc3KM7:TR?= NILVR|ZUSU6JRWK=
MHH-NB-11 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXoRo5KSzVyPUK2MlU5PTFizszN MlnkV2FPT0WU
IST-MEL1 NUnhZYczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJ4LkexO|ch|ryP NGHKfnRUSU6JRWK=
KARPAS-299 NIfWbWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWzcI1KSzVyPUK3MlQ4ODFizszN NVTQRpZuW0GQR1XS
TE-11 M2jhe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPWS|Y2UUN3ME2yO{44OzR{IN88US=> NGLp[JJUSU6JRWK=
769-P NHXufVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDSd5dKSzVyPUK4MlQ2OzNizszN NFixdnNUSU6JRWK=
CAL-72 M1XxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnQ[49KSzVyPUK4MlU2PjFizszN MnLjV2FPT0WU
NCI-H2342 NFfsNGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvYTWM2OD1{OT6zPFA{KM7:TR?= NVnhRphYW0GQR1XS
NCI-H1651 NHnrSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJ7Lki1NFMh|ryP MXPTRW5ITVJ?
OE33 NFfMeZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTNyLkGzOFIh|ryP M33jN3NCVkeHUh?=
HuP-T4 NInnVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\3TWM2OD1|MT60PFM4KM7:TR?= NHjlWnNUSU6JRWK=
U-118-MG NILvNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTN{LkW0OFEh|ryP NELJ[I1USU6JRWK=
SN12C NEfPVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDuTWM2OD1|Mj64PFE2KM7:TR?= M3H4ZXNCVkeHUh?=
TE-5 MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3lR3RuUUN3ME2zN{4yOzZ6IN88US=> NYCxd4R4W0GQR1XS
KM-H2 NIWxbpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTN|LkG2PVkh|ryP M{H6XXNCVkeHUh?=
OVCAR-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXUTWM2OD1|Mz60NVI4KM7:TR?= NEf1TI1USU6JRWK=
NCI-H1304 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzVTHJKSzVyPUOzMlYxOzZizszN M1TTN3NCVkeHUh?=
LU-135 M3jGV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH5dmxKSzVyPUOzMlcxQDZizszN MVLTRW5ITVJ?
S-117 NUfVNFAyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTN|LkeyPFYh|ryP MoPlV2FPT0WU
NCI-H1755 NHKybYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTOTWM2OD1|Mz64NVEh|ryP MUnTRW5ITVJ?
Mo-T MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofqTWM2OD1|Mz64OVk{KM7:TR?= M{nUSHNCVkeHUh?=
SK-OV-3 NWLsVWhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn3eGVjUUN3ME2zN{45QDV2IN88US=> MlH6V2FPT0WU
RCC10RGB M1qxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTN|Lkm0N|Mh|ryP NHfSUmJUSU6JRWK=
COLO-680N MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1GxZWlEPTB;M{SuNVM6PyEQvF2= MkP6V2FPT0WU
KURAMOCHI M2S4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPMelM6UUN3ME2zOE43PDJ3IN88US=> NGLyZ2JUSU6JRWK=
NCI-H661 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHsTWM2OD1|ND64OFQ5KM7:TR?= M1\JNnNCVkeHUh?=
YAPC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\Ue4pKSzVyPUO1Mlk2OzNizszN MnSyV2FPT0WU
NCI-H526 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL0VnpKSzVyPUO3MlI4PzJizszN M3jtNHNCVkeHUh?=
A498 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjFU2RKSzVyPUO4MlA6PTRizszN Mkm3V2FPT0WU
VMRC-RCZ MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHK2co9KSzVyPUO5MlAxPTRizszN NF7zOZlUSU6JRWK=
HCT-116 M4[zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmG4TWM2OD1|OT6wOVgh|ryP Ml\JV2FPT0WU
COLO-320-HSR NELFboFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknoTWM2OD12MD6wOFEh|ryP M2rQbnNCVkeHUh?=
OAW-42 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG0dHZKSzVyPUSwMlA2PDJizszN M3zBd3NCVkeHUh?=
SK-MEL-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTXUZBKSzVyPUSwMlI6OjdizszN MnL2V2FPT0WU
IST-MES1 NXrUUHlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnld5NKSzVyPUSwMlc3PTNizszN NEL2fGNUSU6JRWK=
CP50-MEL-B NHe0fFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTRzLkC3PVch|ryP M4TIeHNCVkeHUh?=
RMG-I MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTR{LkS5NlEh|ryP MXvTRW5ITVJ?
D-336MG NHO4R4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1f3SmlEPTB;NEOuNVE2OiEQvF2= NHXRRpZUSU6JRWK=
SHP-77 NGPjS2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TybWlEPTB;NEOuNVgzQCEQvF2= M3nBTHNCVkeHUh?=
SW872 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILmdohKSzVyPUSzMlIyOjNizszN NV61V5RYW0GQR1XS
DBTRG-05MG MlnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLNTWM2OD12ND62PVk3KM7:TR?= NX\DcVB2W0GQR1XS
COLO-678 NVjnelJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvz[FdKUUN3ME20OU44ODN{IN88US=> NXS5b25IW0GQR1XS
EGI-1 NV\YRo9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml64TWM2OD12Nz6xPFM{KM7:TR?= NVn3XINJW0GQR1XS
KYSE-70 M{\iT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrDTWM2OD12Nz63NlIzKM7:TR?= M{iwPHNCVkeHUh?=
BALL-1 NHnlVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLETWM2OD12Nz64NlU1KM7:TR?= MWLTRW5ITVJ?
MDA-MB-361 M2T0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr6dFRKSzVyPUS4MlA1PiEQvF2= MmXlV2FPT0WU
NCI-H1838 MkXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;SOZBKSzVyPUS4MlM1PThizszN NILjTXlUSU6JRWK=
NCI-H1573 NH72WHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnvcmhrUUN3ME20PE43Pzh3IN88US=> NWnv[lJ5W0GQR1XS
HCC1395 NVSxOok6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zaRWlEPTB;NEiuPVkzKM7:TR?= Ml7QV2FPT0WU
NCI-H2291 Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfmU|hkUUN3ME20PU42QTh6IN88US=> MWPTRW5ITVJ?
RH-18 M4rvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTVyLkC4PFQh|ryP M{PsbHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

17040210 28415756 25395420
Immunofluorescence
PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

25002506
Growth inhibition assay
Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

28415756

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID