BI-D1870

Catalog No.S2843

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Cited by 9 Publications

Cell Rep, 2019, 26(12):3391-3399

PubMed: 30893610 ( click the link to review the publication )

Neurourol Urodyn, 2019, 38(6):1504-1516

PubMed: 31033016 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 37(1):135

PubMed: 29970115 ( click the link to review the publication )

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

4 Customer Reviews

Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

(g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.
HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	NWTYXVE2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1PKZ2lEPTB;MD6wN\|U5KM7:TR?=	NWP1NmRmW0GQR1XS
H9	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRTBwME[wNVkh\|ryP	NIrEcY1USU6JRWK=
KARPAS-45	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV3lfHUzUUN3ME2wMlE3PTJ3IN88US=>	NWf0Z2hnW0GQR1XS
NCI-H720	M4fUeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTBwMUexPVQh\|ryP	NEDVWllUSU6JRWK=
CTV-1	NUDXU2RWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rUdGlEPTB;MD60O\|g4OiEQvF2=	MkPZV2FPT0WU
DU-4475	MnLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXH4b2dmUUN3ME2wMlUxPDF5IN88US=>	M3vmNHNCVkeHUh?=
A172	M2\R[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkS1TWM2OD1yLkWxO\|A2KM7:TR?=	MVnTRW5ITVJ?
EW-18	M17zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4jrcGlEPTB;MD62NlIyOSEQvF2=	NYXMSZprW0GQR1XS
KU812	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzORpR[UUN3ME2wMlYzPjJ\|IN88US=>	MUnTRW5ITVJ?
KP-N-YS	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmTFTWM2OD1yLk[4NlI{KM7:TR?=	MUXTRW5ITVJ?
SBC-1	MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWPl[WxWUUN3ME2wMlY6PTJ2IN88US=>	MknVV2FPT0WU
ECC10	NVTjPXRQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXT3cmNrUUN3ME2wMlcxODl2IN88US=>	NETHe3VUSU6JRWK=
GAMG	M3rTUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX;JR\|UxRTBwN{S3NVch\|ryP	MkDaV2FPT0WU
NCI-H209	MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTBwN{[4NkDPxE1?	NYTBW5RsW0GQR1XS
MC-IXC	NIXWcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHRc3ZKSzVyPUCuO\|k2QDlizszN	MXXTRW5ITVJ?
HSC-3	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LtVmlEPTB;MD64NVc3QSEQvF2=	MoCyV2FPT0WU
IST-SL1	M4n1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYr1WYZ1UUN3ME2wMlg1PTd2IN88US=>	NYjvN\|JPW0GQR1XS
LU-139	NVzT[2t5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX\JR\|UxRTBwOES5OVgh\|ryP	MlzFV2FPT0WU
ML-2	Mom3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWLYNVVbUUN3ME2wMlg2PTd3IN88US=>	NGPCPXpUSU6JRWK=
CAL-62	NGDXXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXrJR\|UxRTBwOEixOVIh\|ryP	NYm0Vpg1W0GQR1XS
HL-60	M2TPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXS5[pNRUUN3ME2wMlg5OzZ{IN88US=>	NXLMVm42W0GQR1XS
KY821	NIHPUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mo\rTWM2OD1yLki4PFEzKM7:TR?=	M2TwcHNCVkeHUh?=
ES7	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIXpSZVKSzVyPUCuPVE3ODdizszN	MXLTRW5ITVJ?
MV-4-11	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnXnTWM2OD1yLkm3PFk4KM7:TR?=	Mn3tV2FPT0WU
Daoy	NXXZ[XN{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHTjTo5KSzVyPUCuPVg4PjdizszN	MXXTRW5ITVJ?
EoL-1-cell	M13QUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIn4TmhKSzVyPUGuNFE5PzhizszN	M4qxU3NCVkeHUh?=
TGW	NXTRO\|RkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHpeWlNUUN3ME2xMlA2OTJ2IN88US=>	MUfTRW5ITVJ?
LAMA-84	M4\GNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHDTWM2OD1zLkGyO\|k1KM7:TR?=	NGLOfXdUSU6JRWK=
KOSC-2	M2DPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVnBOJJYUUN3ME2xMlE{Ozh3IN88US=>	M1r3W3NCVkeHUh?=
A549	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTyTWM2OD1zLkOwPVU2KM7:TR?=	NUTQbmNxW0GQR1XS
CTB-1	M4XENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnriTWM2OD1zLkS0Olc6KM7:TR?=	MYfTRW5ITVJ?
NCI-H292	NHO5T4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mmi3TWM2OD1zLkS2NFY6KM7:TR?=	MYrTRW5ITVJ?
LoVo	MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrLc4lFUUN3ME2xMlQ3PzV3IN88US=>	NEPUXW5USU6JRWK=
BFTC-905	NX;1fGp5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfYXXZGUUN3ME2xMlU3OzN{IN88US=>	MlvTV2FPT0WU
BE-13	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;qTWM2OD1zLkW4O\|A6KM7:TR?=	MWLTRW5ITVJ?
KE-37	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1Htb2lEPTB;MT61PVQ4QCEQvF2=	MVTTRW5ITVJ?
HN	M1\DO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYPpe4MzUUN3ME2xMlYyOzZ6IN88US=>	MlXVV2FPT0WU
A3-KAW	NWm0e4hRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlHBTWM2OD1zLk[yPFM1KM7:TR?=	MULTRW5ITVJ?
NEC8	NFLSeldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3iwVWlEPTB;MT63NFEyPSEQvF2=	MV\TRW5ITVJ?
Ramos-2G6-4C10	NVHtO5QyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPQe2RKSzVyPUGuO\|A1PDRizszN	M3\rcXNCVkeHUh?=
NB10	NVfU[XJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TqSmlEPTB;MT63O\|Y{KM7:TR?=	MoS5V2FPT0WU
NBsusSR	NIjQWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NET3eW5KSzVyPUGuPFI6PjFizszN	NXLwSIhPW0GQR1XS
ES4	MnHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\seGlEPTB;MT64OVE1OyEQvF2=	M3:5NnNCVkeHUh?=
ES8	MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXPobopbUUN3ME2xMlg4PzJ2IN88US=>	MmfFV2FPT0WU
CHL-1	M{K3b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWrkU5ppUUN3ME2xMlk2Pzl{IN88US=>	M3jV[HNCVkeHUh?=
NCI-H2029	Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPsfotRUUN3ME2xMlk4OjRzIN88US=>	MWTTRW5ITVJ?
YKG-1	Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfwdYh1UUN3ME2xMlk5PDN{IN88US=>	NV3PN\|ZoW0GQR1XS
BV-173	MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWDsfIdiUUN3ME2xMlk5PjZ4IN88US=>	NG\PV2FUSU6JRWK=
697	M{\DS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVfqT5FNUUN3ME2yMlAzOjJ6IN88US=>	NX3GVIR7W0GQR1XS
SK-NEP-1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MU\JR\|UxRTJwMES0JO69VQ>?	M2XPbXNCVkeHUh?=
LOXIMVI	M1vucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LCNmlEPTB;Mj6wOFQ{PCEQvF2=	NVy3ZVJNW0GQR1XS
QIMR-WIL	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnnVTWM2OD1{LkC3PFQ6KM7:TR?=	MlHJV2FPT0WU
DU-145	Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYXJR\|UxRTJwMUGwOVYh\|ryP	MnryV2FPT0WU
NB14	NV7aXWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\vOHlKSzVyPUKuNVE{OjFizszN	NUGwWIJZW0GQR1XS
G-361	NFXkWXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTPZ21KSzVyPUKuNVIzOSEQvF2=	M{LoVnNCVkeHUh?=
BPH-1	NIe2dGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlHFTWM2OD1{LkGyPVU4KM7:TR?=	MX3TRW5ITVJ?
KYSE-150	NGnUb5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWnhV4tKUUN3ME2yMlE2OjN2IN88US=>	Ml3LV2FPT0WU
HMV-II	M2rFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXfneHVpUUN3ME2yMlE3PjN\|IN88US=>	MUTTRW5ITVJ?
TE-9	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTSTYhKSzVyPUKuNVc{PzZizszN	MWfTRW5ITVJ?
8-MG-BA	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTJwMkO0OlEh\|ryP	M{nXd3NCVkeHUh?=
ES5	M{HyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnTkTWM2OD1{LkKzOlM{KM7:TR?=	M3\udHNCVkeHUh?=
D-283MED	NXy2c4tOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTJwMkO2PVUh\|ryP	M{LKRXNCVkeHUh?=
SK-N-AS	NHfuTZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWTRWoN[UUN3ME2yMlI6ODV7IN88US=>	MVTTRW5ITVJ?
SW1710	NIq1R4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nTe2lEPTB;Mj6zNFY3OSEQvF2=	M{TyZXNCVkeHUh?=
GCT	Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRTJwM{GzOVgh\|ryP	MkO3V2FPT0WU
AGS	NULmZYZDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIjDdGJKSzVyPUKuN\|Q1ODRizszN	MV;TRW5ITVJ?
HuO9	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTJwM{[4NlQh\|ryP	NHWzNG9USU6JRWK=
MN-60	M37R[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUHJR\|UxRTJwNES4PFMh\|ryP	MlLIV2FPT0WU
NB6	MkLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTJwNEW3O\|kh\|ryP	NW\2XnNwW0GQR1XS
NCI-H1395	MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkP1TWM2OD1{LkS3NVIyKM7:TR?=	MVPTRW5ITVJ?
H4	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYXH[lVEUUN3ME2yMlQ5Ozl\|IN88US=>	MmXpV2FPT0WU
HT-3	MlnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{LyVWlEPTB;Mj61NVAzPCEQvF2=	M4rpbHNCVkeHUh?=
P12-ICHIKAWA	Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4f4V2lEPTB;Mj61NlU2QSEQvF2=	MULTRW5ITVJ?
COLO-800	NXjicWh4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVXLOGNEUUN3ME2yMlU1OTZ4IN88US=>	MX7TRW5ITVJ?
DB	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTJwNUWwNVMh\|ryP	NUTmeWlFW0GQR1XS
LCLC-97TM1	NU\EVWkxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGrROphKSzVyPUKuOlAxOjhizszN	MVHTRW5ITVJ?
Ca9-22	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2DxUmlEPTB;Mj62OVk{OyEQvF2=	NGrEdlZUSU6JRWK=
Becker	MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml75TWM2OD1{Lk[2NFc5KM7:TR?=	MVzTRW5ITVJ?
ACN	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUPXfllHUUN3ME2yMlY3PzlizszN	MnTjV2FPT0WU
SJSA-1	NEfuXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTJwNk[4O{DPxE1?	MYHTRW5ITVJ?
NCI-H1048	M4jiZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV32Z\|Y1UUN3ME2yMlY5OzJzIN88US=>	MYXTRW5ITVJ?
HEL	NFrKO\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXfCNWlrUUN3ME2yMlcxOjV2IN88US=>	Mlq2V2FPT0WU
NCI-H69	MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYLJR\|UxRTJwN{G2NFEh\|ryP	MkXJV2FPT0WU
639-V	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTJwN{G3NFMh\|ryP	MkG5V2FPT0WU
U251	M{T0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTJwN{OwN\|Ih\|ryP	MYHTRW5ITVJ?
NCI-H1792	NWOxZ5h7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXPITokxUUN3ME2yMlc{PzN6IN88US=>	NXfsZ3VOW0GQR1XS
EW-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2Dyc2lEPTB;Mj63OVMzQCEQvF2=	NE\XNYJUSU6JRWK=
ME-180	M3S1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnTnTWM2OD1{Lke3O\|M3KM7:TR?=	MWDTRW5ITVJ?
HH	MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NG[w[GlKSzVyPUKuPFAxODFizszN	M3y5[XNCVkeHUh?=
SW954	MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHvPSZRKSzVyPUKuPFU5OyEQvF2=	M4j1fXNCVkeHUh?=
SF268	NWjSWnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYXUUI1[UUN3ME2yMlg4OjJ3IN88US=>	NEjYR2tUSU6JRWK=
D-566MG	MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mk\HTWM2OD1{LkmxNlk2KM7:TR?=	MlK3V2FPT0WU
EM-2	MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3:3PGlEPTB;Mj65NlE6OyEQvF2=	MonYV2FPT0WU
NCI-H1299	MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoW4TWM2OD1{LkmzO\|M3KM7:TR?=	NF[1VXdUSU6JRWK=
PSN1	NHPpWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIXjbWpKSzVyPUOuNFU4QDZizszN	NYTze49WW0GQR1XS
JVM-3	NYXUW4hGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnPuTWM2OD1\|LkC2O\|U3KM7:TR?=	MmTWV2FPT0WU
D-502MG	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEjRZnNKSzVyPUOuNFcxOTlizszN	M3zXVHNCVkeHUh?=
SCC-4	MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXMTWM2OD1\|LkC5Nlc3KM7:TR?=	MnTYV2FPT0WU
GMS-10	NX3wdpVLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTNwMEmzPFgh\|ryP	MlvpV2FPT0WU
A427	M13oZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYK5VpJkUUN3ME2zMlExQDd\|IN88US=>	M{TCU3NCVkeHUh?=
NH-12	MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXxdVFKSzVyPUOuNVE1PTZizszN	NYPYeYtwW0GQR1XS
KM12	NELKUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXzhXnd7UUN3ME2zMlEzOjd\|IN88US=>	MmTnV2FPT0WU
GI-1	M13SXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoTMTWM2OD1\|LkG1NlU2KM7:TR?=	MW\TRW5ITVJ?
TE-8	NUnmS4t[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLtd2NFUUN3ME2zMlE6OjNzIN88US=>	MkTtV2FPT0WU
MKN1	MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnzvTWM2OD1\|LkKwPFc2KM7:TR?=	Mk\1V2FPT0WU
NCI-H810	NH3UWm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXKTWM2OD1\|LkKyNVU2KM7:TR?=	NYfDWoJFW0GQR1XS
GOTO	NUPjbnl7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYSxeI1xUUN3ME2zMlI5ODB2IN88US=>	Mn\vV2FPT0WU
T98G	NFXBcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1njWmlEPTB;Mz6yPFIyPiEQvF2=	NWXPd3dkW0GQR1XS
HD-MY-Z	M4DGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTNwM{[1OFIh\|ryP	M4\p[nNCVkeHUh?=
SNU-C2B	NH\UbJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoHHTWM2OD1\|LkO5NFk4KM7:TR?=	MXHTRW5ITVJ?
MOLT-4	MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTNwM{mwPVgh\|ryP	Ml;uV2FPT0WU
RPMI-7951	NGHzVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXHGdmpsUUN3ME2zMlM6PzNizszN	MoflV2FPT0WU
EW-11	M3PreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH\V[WlKSzVyPUOuOFEzOjRizszN	NYPh[pV6W0GQR1XS
RD	NVTN[YZbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkDqTWM2OD1\|LkSzNVMzKM7:TR?=	NV3aUY1ZW0GQR1XS
SW48	NGK4b4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkXWTWM2OD1\|LkSzN\|U5KM7:TR?=	NVXRd2x4W0GQR1XS
BB65-RCC	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\qV3QxUUN3ME2zMlQ2Ozl4IN88US=>	MneyV2FPT0WU
Ca-Ski	M1Tibmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoPFTWM2OD1\|LkS3OVE1KM7:TR?=	NHm1WoRUSU6JRWK=
CHP-134	M33GPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXrme5luUUN3ME2zMlQ5PzV6IN88US=>	NE\ye4lUSU6JRWK=
CAL-33	NH7IZoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTQTWM2OD1\|LkWzN\|YzKM7:TR?=	NIC5PJNUSU6JRWK=
TYK-nu	M4nLXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LwfWlEPTB;Mz61N\|Y4PiEQvF2=	NVS4blVvW0GQR1XS
LB831-BLC	NGH2VJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;adWlEPTB;Mz61OFAyPiEQvF2=	M{\JdHNCVkeHUh?=
KU-19-19	MknrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\3c2lEPTB;Mz62NFMxPCEQvF2=	MVnTRW5ITVJ?
KG-1	MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVrJR\|UxRTNwNkGxNFYh\|ryP	NYLtN3JHW0GQR1XS
COLO-829	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYX6WHdHUUN3ME2zMlY3PjF6IN88US=>	NEW2cJdUSU6JRWK=
HUTU-80	Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGC2W3RKSzVyPUOuOlY3OjFizszN	NFPuT5pUSU6JRWK=
NCI-H446	MojiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYrXTHZuUUN3ME2zMlY5OzRizszN	NEfXSZZUSU6JRWK=
LB2241-RCC	M4HHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmPOTWM2OD1\|Lk[4OlI2KM7:TR?=	NULPN5RKW0GQR1XS
JEG-3	NWeyWZc{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoOyTWM2OD1\|Lk[5NVkh\|ryP	Mo\tV2FPT0WU
LNCaP-Clone-FGC	M3ru[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTNwN{CwOFEh\|ryP	NVrm[WhIW0GQR1XS
M059J	NWDQcmt4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlOwTWM2OD1\|LkexOFY5KM7:TR?=	MnPuV2FPT0WU
SK-MES-1	MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTNwN{OwN{DPxE1?	MljiV2FPT0WU
GT3TKB	MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrnPZZjUUN3ME2zMlc2PjB2IN88US=>	MkXoV2FPT0WU
DOK	NEfmOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIPIVYRKSzVyPUOuO\|Y2OjZizszN	MlrvV2FPT0WU
HO-1-N-1	M2XIWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFG4[XJKSzVyPUOuO\|k5ODFizszN	MUfTRW5ITVJ?
MZ1-PC	MmDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLRV\|dKSzVyPUOuPFI5QDNizszN	NWPJTINmW0GQR1XS
8305C	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLUeo9{UUN3ME2zMlg5QTR\|IN88US=>	M1TSbXNCVkeHUh?=
CGTH-W-1	NXT4UopnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\wN4JRUUN3ME2zMlk{PTB2IN88US=>	NWPkRno{W0GQR1XS
LU-134-A	MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn\wTWM2OD1\|Lkm1OFIzKM7:TR?=	MWXTRW5ITVJ?
C32	NEj0ZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH63d\|hKSzVyPUOuPVY2QDFizszN	MXTTRW5ITVJ?
MOLT-13	NYjXT3d{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoLWTWM2OD1\|Lkm2PFU3KM7:TR?=	Mln4V2FPT0WU
A375	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVjJR\|UxRTRwMEWxOlIh\|ryP	NF\6WZVUSU6JRWK=
CAL-12T	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4\PXGlEPTB;ND6wOVc6PSEQvF2=	Mk[3V2FPT0WU
IGR-1	NI\0VXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnHqTWM2OD12LkGwNlc1KM7:TR?=	M1PNPHNCVkeHUh?=
LB1047-RCC	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTRwMUC0OFEh\|ryP	MoW5V2FPT0WU
BHT-101	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnlTWM2OD12LkGwOlg{KM7:TR?=	MWfTRW5ITVJ?
A431	NGfab5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LsR2lEPTB;ND6xOFA5OSEQvF2=	NXLyOZBCW0GQR1XS
EPLC-272H	NYm5foZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7se5ZKSzVyPUSuNVc2QTZizszN	MUPTRW5ITVJ?
HT-1376	NIDReFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnEcIN1UUN3ME20MlI{ODV7IN88US=>	MYPTRW5ITVJ?
HCC1954	NYrIdplnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWPJR\|UxRTRwMkW3OFYh\|ryP	MXfTRW5ITVJ?
KYSE-510	MmPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmixTWM2OD12LkK2NFkh\|ryP	MX;TRW5ITVJ?
PANC-03-27	NWrFTGJIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\XN5NVUUN3ME20MlMxODh\|IN88US=>	M3u0UHNCVkeHUh?=
MDA-MB-157	M3rj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH3HTGRKSzVyPUSuN\|A3PTZizszN	NGjoUoVUSU6JRWK=
HOP-62	MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlXRTWM2OD12LkOwPFU3KM7:TR?=	M1vvfHNCVkeHUh?=
ETK-1	M4jzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4rDVGlEPTB;ND6zOlIxOyEQvF2=	NFX1WGhUSU6JRWK=
MIA-PaCa-2	Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTRwM{[yNlch\|ryP	M1nCbHNCVkeHUh?=
MHH-PREB-1	M4HSNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH3VbIJKSzVyPUSuN\|k4PzNizszN	NVjlO2lWW0GQR1XS
LXF-289	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWP1RWZrUUN3ME20MlQxOjB{IN88US=>	NHfjR2tUSU6JRWK=
ATN-1	NYrmcIo{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4D5TWlEPTB;ND60NlM1OSEQvF2=	NFyyTGtUSU6JRWK=
8505C	NHHwcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlrITWM2OD12LkS1PFI2KM7:TR?=	NXqwW21EW0GQR1XS
HOS	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV;JR\|UxRTRwNE[0OVMh\|ryP	MlTVV2FPT0WU
U-266	MoriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoDjTWM2OD12Lk[xNFMzKM7:TR?=	M4LZeHNCVkeHUh?=
5637	MnyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1Xjc2lEPTB;ND62NVQ1PCEQvF2=	NH63fFJUSU6JRWK=
GCIY	NWTJdFFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWG0WotLUUN3ME20MlcyODF3IN88US=>	NYPzRYVyW0GQR1XS
MDA-MB-231	NHnJRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTRwN{KxNVUh\|ryP	MUTTRW5ITVJ?
RKO	NFviO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HlfmlEPTB;ND63NlgyPyEQvF2=	NIX1UHJUSU6JRWK=
COR-L23	M1vEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUT4Rm9QUUN3ME20Mlc1OjV4IN88US=>	Mn3KV2FPT0WU
DJM-1	M1TBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmHBTWM2OD12Lke5O\|I6KM7:TR?=	NGLYO\|RUSU6JRWK=
D-423MG	NWPx[FRIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVfLT5h3UUN3ME20MlgxQDB\|IN88US=>	M{PzWHNCVkeHUh?=
DMS-114	MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1XXRmlEPTB;ND64NVM5PiEQvF2=	MX7TRW5ITVJ?
MHH-ES-1	NIjNNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXBTWM2OD12LkiyOVA1KM7:TR?=	MmjYV2FPT0WU
CAL-51	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTRwOE[4OFMh\|ryP	MlPKV2FPT0WU
SW626	MkHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M17pZ2lEPTB;ND64PVY6PyEQvF2=	NXzWNlFlW0GQR1XS
COLO-824	NUHJT3pGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWjJR\|UxRTRwOUC0NFgh\|ryP	MUXTRW5ITVJ?
NCI-H1437	MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHu0[3FKSzVyPUSuPVI6OyEQvF2=	MoHyV2FPT0WU
CAL-39	NIfCe3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml;yTWM2OD12LkmzPVg5KM7:TR?=	NEK5XZdUSU6JRWK=
PC-3	NEHhVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTRwOUS2OFgh\|ryP	NUjacIVGW0GQR1XS
A101D	NH7ucFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWK0eGt[UUN3ME20Mlk3QDZ3IN88US=>	NWP5[mVSW0GQR1XS
ES1	Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4iwRWlEPTB;NT6wNFE{KM7:TR?=	MnTaV2FPT0WU
TE-1	NWCzXGd7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjnd41KSzVyPUWuNFM3PjZizszN	M4LPe3NCVkeHUh?=
KP-N-YN	NHyzPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnPUTWM2OD13LkC1Olch\|ryP	NF\vPZBUSU6JRWK=
EFO-27	Ml6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3\vU2lEPTB;NT6wOlMzQSEQvF2=	MXrTRW5ITVJ?
BT-549	M{\tNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmfzTWM2OD13LkC3O\|M3KM7:TR?=	MWfTRW5ITVJ?
HLE	M1vpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGnmdlZKSzVyPUWuNVE4OzRizszN	NEnHTW5USU6JRWK=
SW982	MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGDk[YpKSzVyPUWuNVM{PzRizszN	MkPuV2FPT0WU
SCC-25	M3XSbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWi3WIVYUUN3ME21MlE6ODR4IN88US=>	NV;wXWVpW0GQR1XS
SK-MEL-28	NEToTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnq0TWM2OD13LkKwN\|E{KM7:TR?=	NF6xcoNUSU6JRWK=
CaR-1	NEfrU4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHl[pVFUUN3ME21MlIxPzJ4IN88US=>	M3TzPXNCVkeHUh?=
MLMA	MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4HEfGlEPTB;NT6yN\|Q{PiEQvF2=	NYnZfXlXW0GQR1XS
VM-CUB-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWrJR\|UxRTVwMkO0N\|kh\|ryP	M1e5XHNCVkeHUh?=
KNS-42	NYfQ[4tkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXjKSpY5UUN3ME21MlI3OTZizszN	MXzTRW5ITVJ?
TK10	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NE[3b\|lKSzVyPUWuN\|YxQDZizszN	M{T0NHNCVkeHUh?=
MEG-01	NELHdXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NInoRnpKSzVyPUWuN\|YzPzRizszN	M4Hj[3NCVkeHUh?=
DEL	MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTmTWM2OD13LkO5NFI{KM7:TR?=	MXXTRW5ITVJ?
SJRH30	NY\JVXNPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M13PT2lEPTB;NT6zPVIyOyEQvF2=	M4Ty[nNCVkeHUh?=
SK-PN-DW	M3P1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoLITWM2OD13LkSzOVg6KM7:TR?=	M2DSUHNCVkeHUh?=
TE-10	M3nLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2HleGlEPTB;NT60OFg6OyEQvF2=	NGTzW2hUSU6JRWK=
KNS-81-FD	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHvrOlFKSzVyPUWuOVAxQTJizszN	NXy5[JJrW0GQR1XS
BHY	NHrVOo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFfrRZBKSzVyPUWuOVExPyEQvF2=	MkTGV2FPT0WU
KYSE-270	M2PmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYjJR\|UxRTVwNUO1N\|Yh\|ryP	M{\WSHNCVkeHUh?=
NCI-H650	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV;JR\|UxRTVwNUexNVQh\|ryP	NXnlZ3BwW0GQR1XS
L-363	MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M17aVGlEPTB;NT62PVQ4PiEQvF2=	NVSzbWdUW0GQR1XS
TCCSUP	NInlT49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY\nNZgzUUN3ME21MlcyPzd6IN88US=>	MV;TRW5ITVJ?
SCH	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTVwN{S3Olch\|ryP	MUHTRW5ITVJ?
HTC-C3	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1;xPGlEPTB;NT63O\|Y1PCEQvF2=	MoHGV2FPT0WU
J-RT3-T3-5	NIS2bYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVfJR\|UxRTVwOEC3PVQh\|ryP	NW\aV3ZpW0GQR1XS
Hs-578-T	NF3MZo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPxcXpiUUN3ME21Mlg{PjB5IN88US=>	MnvhV2FPT0WU
M14	M2rrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYnJR\|UxRTVwOE[3NlYh\|ryP	MmPCV2FPT0WU
HT-144	NVv4SGN7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIK2fVJKSzVyPUWuPFY5OzJizszN	MUDTRW5ITVJ?
CAL-54	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTVwOUOzNVQh\|ryP	M3Pjb3NCVkeHUh?=
T47D	NXTiUGUzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnztTWM2OD13Lkm2NVIh\|ryP	MW\TRW5ITVJ?
GB-1	NGTncoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1POVWlEPTB;Nj6wNlA3QCEQvF2=	MkLPV2FPT0WU
HSC-2	M4XoOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml7KTWM2OD14LkGyN\|U{KM7:TR?=	NV\0dplNW0GQR1XS
SiHa	MkT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3nRUWlEPTB;Nj6xOFA6PyEQvF2=	M4TQbXNCVkeHUh?=
OMC-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmHwTWM2OD14LkO1OFQyKM7:TR?=	NYTXPYU5W0GQR1XS
HGC-27	M1TkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTZwM{W3PFYh\|ryP	MYHTRW5ITVJ?
FTC-133	NF7CTldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2DCOWlEPTB;Nj60OlU2OSEQvF2=	M3PmbXNCVkeHUh?=
KS-1	NVrWOIZsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLXTphMUUN3ME22MlUzOTR5IN88US=>	NXLBV4dKW0GQR1XS
HT-1080	M4C4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3\ONWlEPTB;Nj61OFA1OiEQvF2=	NEjIOYxUSU6JRWK=
SKG-IIIa	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUPMdVF6UUN3ME22MlU3OjZ\|IN88US=>	MlzjV2FPT0WU
OCUB-M	MkSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm\MTWM2OD14Lk[wO\|ch\|ryP	M2TUW3NCVkeHUh?=
MDA-MB-175-VII	NF7IUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVvJR\|UxRTZwNkKwPUDPxE1?	NGLZSFhUSU6JRWK=
BB30-HNC	NFzXc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYjJR\|UxRTZwNke0OFQh\|ryP	NFLsRVVUSU6JRWK=
D-542MG	M1f1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEH1blJKSzVyPU[uO\|MxQSEQvF2=	NFrWe\|hUSU6JRWK=
NCI-H2405	M1HsXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYLJR\|UxRTZwN{S4OVUh\|ryP	MoDEV2FPT0WU
SW1573	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVrCR29VUUN3ME22Mlc5OzF7IN88US=>	MXnTRW5ITVJ?
NCI-SNU-1	NET1eHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3m2UGlEPTB;Nj63PVAzOiEQvF2=	NUXpSItVW0GQR1XS
RT-112	NYLTUoFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDYUlluUUN3ME22Mlc6PDZ\|IN88US=>	M{iz[XNCVkeHUh?=
COR-L88	NFf2TndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIPzdHhKSzVyPU[uO\|k4QTFizszN	NFXn[YdUSU6JRWK=
SCC-9	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTZwOEK1OUDPxE1?	M33zOXNCVkeHUh?=
U-87-MG	MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTZwOEO4NlYh\|ryP	NI\qO5VUSU6JRWK=
Detroit562	M3Hjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYfJR\|UxRTZwOEW5PVEh\|ryP	MmPuV2FPT0WU
LC-2-ad	MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnCb2ZKSzVyPU[uPFYzQTJizszN	MVPTRW5ITVJ?
IGROV-1	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTZwOUK1PFMh\|ryP	MlPVV2FPT0WU
OVCAR-8	M2rXS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MonzTWM2OD14Lkm0NlI6KM7:TR?=	MlWzV2FPT0WU
SNU-387	NGq0OI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1LzcWlEPTB;Nj65PVUyPiEQvF2=	MlPqV2FPT0WU
TGBC1TKB	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLmOpdmUUN3ME23MlE2Ojd5IN88US=>	NFHwcFJUSU6JRWK=
NOS-1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTHTWM2OD15LkKwOFE2KM7:TR?=	MofpV2FPT0WU
HEC-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fHdGlEPTB;Nz6yOVM5PyEQvF2=	NIDPPFRUSU6JRWK=
GI-ME-N	M1XTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmG1TWM2OD15LkK5NVU5KM7:TR?=	MmLEV2FPT0WU
KYSE-520	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTdwMkmyPUDPxE1?	MYTTRW5ITVJ?
SNU-423	M4jadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoTnTWM2OD15LkK5OFUzKM7:TR?=	NVjQenZFW0GQR1XS
C-33-A	NV;pUW9DT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{fPS2lEPTB;Nz60O\|gzKM7:TR?=	MX3TRW5ITVJ?
SK-UT-1	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF\Mb2lKSzVyPUeuOVQ5OjlizszN	MWnTRW5ITVJ?
OVCAR-4	NXPUb2prT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGHpdI5KSzVyPUeuOVUzPiEQvF2=	NIrEWJRUSU6JRWK=
KYSE-450	MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{CzPWlEPTB;Nz62N\|c6OSEQvF2=	NGflVnRUSU6JRWK=
RS4-11	M1T1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVjQNGprUUN3ME23MlcxOTl4IN88US=>	NF\ZXmpUSU6JRWK=
OVCAR-5	M1vaXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVnJTWl6UUN3ME23MlgzOzJ7IN88US=>	NVXHN49SW0GQR1XS
K5	NUe0VHVlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4KxNWlEPTB;Nz64O\|QzKM7:TR?=	MXjTRW5ITVJ?
786-0	NXexTlRjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXEeYlFUUN3ME24MlA{ODl3IN88US=>	NIThellUSU6JRWK=
NCI-H747	NIXl[\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mlv6TWM2OD16LkC0OFU4KM7:TR?=	M1r6TXNCVkeHUh?=
CAL-27	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MleyTWM2OD16LkGyO\|Ih\|ryP	MnXhV2FPT0WU
FADU	MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jWeGlEPTB;OD6xO\|U1OyEQvF2=	NUHNPFhyW0GQR1XS
SW780	NXvrbmpOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHLieo9KSzVyPUiuNVg5OjFizszN	M{fU[nNCVkeHUh?=
ACHN	M3zrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFW2SYRKSzVyPUiuNlI2OjlizszN	NVrQRVRkW0GQR1XS
TE-6	NEDrR4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRThwMkO3PFgh\|ryP	MkHDV2FPT0WU
NCI-H2087	M1zHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2DjNGlEPTB;OD6zOlE2QCEQvF2=	NESwZ2dUSU6JRWK=
NCI-H2122	M{jQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHvMOZVKSzVyPUiuOFA1PzlizszN	MULTRW5ITVJ?
SK-LU-1	NYDNVmt[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlXFTWM2OD16LkSzPVk4KM7:TR?=	MknjV2FPT0WU
22RV1	NGXxcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfve3ViUUN3ME24MlYyPzh4IN88US=>	MlXsV2FPT0WU
MEL-JUSO	NGHSXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVPLT3BIUUN3ME24MlY5Pjd3IN88US=>	MoDmV2FPT0WU
UM-UC-3	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX\HTZFJUUN3ME24MlcyOzlizszN	MkTRV2FPT0WU
HuH-7	NUjQbGplT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF;ETGFKSzVyPUiuO\|MxOTJizszN	MVHTRW5ITVJ?
SNU-449	MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoryTWM2OD16Lke1NlY2KM7:TR?=	NXyzc\|dHW0GQR1XS
RVH-421	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;6RWdOUUN3ME24Mlc2Ozl6IN88US=>	NUXqWmE2W0GQR1XS
MFM-223	MlvCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRThwOEC3N\|Uh\|ryP	M2XDZnNCVkeHUh?=
CHP-212	Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRThwOEKyOlch\|ryP	MV7TRW5ITVJ?
NCI-H28	NWe0ZllET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX[xOoN3UUN3ME24Mlg2OTh3IN88US=>	MV;TRW5ITVJ?
C8166	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1freWlEPTB;OD64Olc4OiEQvF2=	NWDUVI1TW0GQR1XS
SCC-15	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{PEOWlEPTB;OD64O\|E6PiEQvF2=	NU\I[GY4W0GQR1XS
DMS-273	NVLQRYxxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIrLOolKSzVyPUiuPFk3OjNizszN	MYnTRW5ITVJ?
MPP-89	NFrFbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojETWM2OD16LkmxN\|QyKM7:TR?=	M1XNc3NCVkeHUh?=
EW-22	NH:zN\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4jSUGlEPTB;OD65NVM5OiEQvF2=	MXzTRW5ITVJ?
RCM-1	NGDFb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUftV4I2UUN3ME24Mlk3PDh4IN88US=>	NEjNS3RUSU6JRWK=
BT-474	Mn;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV\zbZdSUUN3ME24Mlk5QDd{IN88US=>	MYrTRW5ITVJ?
TI-73	NIjkd\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFq3TIhKSzVyPUmuNFM1QTZizszN	NFfnc\|lUSU6JRWK=
ES3	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWHJR\|UxRTlwMEWxOVYh\|ryP	NEfqU3VUSU6JRWK=
NB17	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYnJR\|UxRTlwMUS1N\|Uh\|ryP	MoKzV2FPT0WU
MOLT-16	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUXxV5o1UUN3ME25MlE3PjV3IN88US=>	NFmwe5ZUSU6JRWK=
TGBC11TKB	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInJUYlKSzVyPUmuNVkzODVizszN	MnzlV2FPT0WU
NB12	M3jLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3XITWlEPTB;OT6zOFA5OSEQvF2=	M2j6fHNCVkeHUh?=
MEL-HO	M1zVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2\KR2lEPTB;OT60NFIh\|ryP	NVLTfJF[W0GQR1XS
HuCCT1	M1myRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYHJR\|UxRTlwNEe0NFYh\|ryP	NHvEU45USU6JRWK=
A704	NWfVU2hXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTlwNEe3OFUh\|ryP	NUTBeoozW0GQR1XS
SW756	NVf1fWE5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7XTGRZUUN3ME25MlU2OzZzIN88US=>	MnHwV2FPT0WU
SAS	NGHtOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2PyOmlEPTB;OT61PFQ2PSEQvF2=	MnvUV2FPT0WU
KINGS-1	NX3ObnYxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mmn3TWM2OD17Lk[5N\|ch\|ryP	Ml63V2FPT0WU
NKM-1	NXjNZXpyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlqwTWM2OD17LkizPVY1KM7:TR?=	MnG0V2FPT0WU
C2BBe1	NGfldlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTrToJKSzVyPUmuPFYzODRizszN	MVLTRW5ITVJ?
A204	NGjHbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MW\JR\|UxRTlwOEm3OVUh\|ryP	NG\CV5dUSU6JRWK=
G-401	M1vtWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTlwOUC0OFkh\|ryP	NFzQ[3hUSU6JRWK=
PFSK-1	Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnnXTWM2OD17Lkm1OlY6KM7:TR?=	MWPTRW5ITVJ?
KYSE-410	NYPBcoZGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkjTTWM2OD1zMD6wOlE2KM7:TR?=	MXfTRW5ITVJ?
SK-MEL-2	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTFyLkG1PFgh\|ryP	NUHjclZvW0GQR1XS
NB5	M4PLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXPBU3B6UUN3ME2xNE42PDB3IN88US=>	MkP2V2FPT0WU
NTERA-S-cl-D1	M1LENGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmfNTWM2OD1zMD61OFc2KM7:TR?=	NEXSR2JUSU6JRWK=
MZ2-MEL	NUjWdYU3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVS1TYhPUUN3ME2xNE43PjJizszN	Ml;3V2FPT0WU
SF539	NXm1cngxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1v6b2lEPTB;MUCuO\|E5QCEQvF2=	M{KzXHNCVkeHUh?=
CAL-120	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVXJR\|UxRTFyLke1PVch\|ryP	MnHiV2FPT0WU
GR-ST	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF;1UItKSzVyPUGxMlI6QCEQvF2=	NWPqeI1KW0GQR1XS
IA-LM	MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEG0eFFKSzVyPUGxMlM1QDZizszN	NXTVe2FqW0GQR1XS
NCI-H2452	NVza[pI5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFvWbXVKSzVyPUGxMlM6OjdizszN	NI\M[ldUSU6JRWK=
NCI-H1648	NHHiRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13ydmlEPTB;MUGuOFYzQSEQvF2=	MY\TRW5ITVJ?
YH-13	Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYi0S25NUUN3ME2xNU41PzR{IN88US=>	M3;rUHNCVkeHUh?=
NCI-H2228	NXXBR4R5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTFzLkS5Nlgh\|ryP	MVjTRW5ITVJ?
LN-405	NIHV[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH7mfoxKSzVyPUGxMlU6OjdizszN	MlW5V2FPT0WU
647-V	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XtXGlEPTB;MUGuOVk4PCEQvF2=	NEnPSJdUSU6JRWK=
HCC1806	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlTtTWM2OD1zMT62NVM1KM7:TR?=	NHnlS\|lUSU6JRWK=
HPAF-II	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlfRTWM2OD1zMT64N\|U3KM7:TR?=	NHzMTnpUSU6JRWK=
BB49-HNC	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\vTWM2OD1zMT64N\|c2KM7:TR?=	MkfLV2FPT0WU
KGN	MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTFzLki1PFkh\|ryP	NVPyTYE1W0GQR1XS
NOMO-1	NHPJZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2HCS2lEPTB;MUGuPFU6PyEQvF2=	NHjUTZNUSU6JRWK=
A388	NFHTXppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXXJR\|UxRTFzLki4NFgh\|ryP	M3HHVnNCVkeHUh?=
Saos-2	MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTF{LkKwNFMh\|ryP	M2HwW3NCVkeHUh?=
SK-HEP-1	NXXSVmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnjUno6UUN3ME2xNk4zPjF\|IN88US=>	NHe0RXBUSU6JRWK=
HCE-4	MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXvFRnRJUUN3ME2xNk4zPjl7IN88US=>	MXzTRW5ITVJ?
NCI-H1581	MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4\6XWlEPTB;MUKuNlgyQSEQvF2=	NHvjcndUSU6JRWK=
NCI-H23	NF7OblJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTF{LkOxNlUh\|ryP	NXn3dYFLW0GQR1XS
NCI-H596	NWewNYRQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHURZJnUUN3ME2xNk41Pzl6IN88US=>	MkjwV2FPT0WU
NB69	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fiSWlEPTB;MUKuO\|U5PSEQvF2=	MYTTRW5ITVJ?
ChaGo-K-1	NGrxNllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2jLd2lEPTB;MUKuO\|Y1QSEQvF2=	MlLmV2FPT0WU
EFM-19	NYjwbFgxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUPaPWN1UUN3ME2xNk44PzF5IN88US=>	NIX4ZYNUSU6JRWK=
SW962	Ml:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTOTWM2OD1zMj64NlI{KM7:TR?=	MnzvV2FPT0WU
KALS-1	NH;IZpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkDITWM2OD1zMz6wPVUh\|ryP	NGPLTndUSU6JRWK=
MDA-MB-415	Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXiTWM2OD1zMz6xOlA6KM7:TR?=	NUWxPY16W0GQR1XS
SW684	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M13MVGlEPTB;MUOuNVg3OSEQvF2=	NIrHOWFUSU6JRWK=
NCI-H2052	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3u3dmlEPTB;MUOuN\|g1QCEQvF2=	MoHDV2FPT0WU
HOP-92	NH:zRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYjJR\|UxRTF\|Lke5PVch\|ryP	MVTTRW5ITVJ?
OE19	Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUfJR\|UxRTF2LkCwO\|Uh\|ryP	M3;Rd3NCVkeHUh?=
D-392MG	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIGwTJBKSzVyPUG0MlEzOTFizszN	MomxV2FPT0WU
A253	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX31Z4dRUUN3ME2xOE4zOjVizszN	MnPxV2FPT0WU
NCI-H1155	NH\xbmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGP4TYVKSzVyPUG0MlI4PDdizszN	M1nV[3NCVkeHUh?=
SNB75	MkPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLOfoFKSzVyPUG0MlM5QTNizszN	NUT1fpVjW0GQR1XS
23132-87	NYT1ToNQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojDTWM2OD1zND64N\|U{KM7:TR?=	NF7Z[ZBUSU6JRWK=
Calu-3	NIHnV\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1XHTWlEPTB;MUSuPFc1OyEQvF2=	MXPTRW5ITVJ?
CW-2	M1q4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTF3LkCyNlMh\|ryP	M4DYb3NCVkeHUh?=
COLO-679	NULIeHhNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTNTWM2OD1zNT6xNFE{KM7:TR?=	MYXTRW5ITVJ?
NCI-SNU-5	Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{H4OWlEPTB;MUWuOVU5QSEQvF2=	NIHLbGhUSU6JRWK=
AN3-CA	MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M173fWlEPTB;MUWuOlQ3QCEQvF2=	MUnTRW5ITVJ?
SF126	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkLZTWM2OD1zNT63Nlg2KM7:TR?=	MV3TRW5ITVJ?
D-247MG	M4j2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmiyTWM2OD1zNT64OVM{KM7:TR?=	NWj4dpNWW0GQR1XS
UACC-62	M{HiPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWPJR\|UxRTF3Lkm2OkDPxE1?	MmfvV2FPT0WU
GP5d	NGDaNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTJTWM2OD1zNj6xNVcyKM7:TR?=	MorTV2FPT0WU
HuO-3N1	MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLjTWM2OD1zNj6yOFc{KM7:TR?=	NXKwUWoyW0GQR1XS
NCI-H1092	Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVTKXJFQUUN3ME2xOk43Ojl5IN88US=>	NYLrW2ROW0GQR1XS
HCC1187	NYn5enh3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX3JR\|UxRTF4Lk[1OVch\|ryP	MnLpV2FPT0WU
G-402	M{DFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\XUINbUUN3ME2xOk45PTZ3IN88US=>	MX3TRW5ITVJ?
HT55	M3\jfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2\nS2lEPTB;MU[uPFc2OSEQvF2=	MnzFV2FPT0WU
NCI-H2009	NGizT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnzhTWM2OD1zNj65NlY3KM7:TR?=	NUGwXGs3W0GQR1XS
SH-4	M4fTSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUfJUHNCUUN3ME2xOk46QTJizszN	NUjOVWFwW0GQR1XS
SW1783	NGXseIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTF4Lkm5PVgh\|ryP	MoOyV2FPT0WU
HT	M3HVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTFT2t5UUN3ME2xO{4yQTZ2IN88US=>	MnPLV2FPT0WU
CP66-MEL	MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTF5LkOwNUDPxE1?	M3\1cXNCVkeHUh?=
BEN	M1;GPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLUR\|VRUUN3ME2xO{42PjJ4IN88US=>	M3LyT3NCVkeHUh?=
HCC38	NET0RXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWjJR\|UxRTF5Lke2PVgh\|ryP	MYfTRW5ITVJ?
LAN-6	NITtfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M171NmlEPTB;MUeuPFQ5PSEQvF2=	MWrTRW5ITVJ?
RERF-LC-MS	M13TVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVy1NWQyUUN3ME2xO{46OTJ7IN88US=>	Mn7KV2FPT0WU
NCI-H1770	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXPJR\|UxRTF5Lkm0PVEh\|ryP	NF7WXXpUSU6JRWK=
LCLC-103H	NYDIOngzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX\JR\|UxRTF6LkC1NUDPxE1?	MXjTRW5ITVJ?
NCI-H520	MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTF6LkOyPFEh\|ryP	M132OHNCVkeHUh?=
LU-65	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTF6LkSwOFMh\|ryP	MkmxV2FPT0WU
SK-MEL-3	MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLQTWM2OD1zOD62Olc6KM7:TR?=	NITQe4hUSU6JRWK=
LK-2	M{TQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjtWmhKSzVyPUG4Mlc4OjNizszN	NIOwR4NUSU6JRWK=
PANC-08-13	M3XCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MonVTWM2OD1zOD63PFg6KM7:TR?=	MV\TRW5ITVJ?
NCI-H460	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXuTWM2OD1zOD64OFY3KM7:TR?=	MkO1V2FPT0WU
COLO-684	NIHjT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml3sTWM2OD1zOD65PVU3KM7:TR?=	M2[3[nNCVkeHUh?=
RPMI-2650	MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlzPTWM2OD1zOT6wNVIh\|ryP	NHn4emRUSU6JRWK=
NY	NFHJb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFTkSIxKSzVyPUG5MlE2PjdizszN	MVvTRW5ITVJ?
NB7	M2nwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NETUeohKSzVyPUG5MlE4PTNizszN	NHXxUZhUSU6JRWK=
NCI-H358	M{m0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4LYO2lEPTB;MUmuNlY4OyEQvF2=	NHX4O2tUSU6JRWK=
MC116	M2\xcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1\pNmlEPTB;MUmuOVM{OSEQvF2=	NWTC[YloW0GQR1XS
MS-1	NH\r[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYDuXFhKUUN3ME2xPU43OTB\|IN88US=>	NVfxeJR7W0GQR1XS
NCI-H82	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnnJTWM2OD1zOT62PFc5KM7:TR?=	Mnz6V2FPT0WU
OCI-AML2	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTF7LkewN\|Ih\|ryP	MWjTRW5ITVJ?
LS-123	NGWzTGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVW5fpNvUUN3ME2yNE4xOTl2IN88US=>	MWfTRW5ITVJ?
PC-14	NVnafFRGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3nD[2lEPTB;MkCuNVg{PCEQvF2=	MnTUV2FPT0WU
NCI-H1703	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTJyLkixO\|Mh\|ryP	M3vScXNCVkeHUh?=
Calu-6	M3zvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWTPfXJqUUN3ME2yNU4yODB3IN88US=>	MVTTRW5ITVJ?
no-11	NH;PdGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXjJR\|UxRTJzLkG2NFIh\|ryP	MlTiV2FPT0WU
NCI-H727	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1jGfWlEPTB;MkGuN\|Q6OyEQvF2=	M3\hPHNCVkeHUh?=
DSH1	MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHaNWZXUUN3ME2yNU4{QDd7IN88US=>	M13MTnNCVkeHUh?=
KYSE-140	Mlm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mki4TWM2OD1{MT63NlcyKM7:TR?=	MUXTRW5ITVJ?
RH-1	MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWXq[FFEUUN3ME2yNU45QDNizszN	NYP6UINvW0GQR1XS
HAL-01	Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYfJR\|UxRTJ{LkC0NVgh\|ryP	MYPTRW5ITVJ?
RXF393	NWn3b\|R[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWPXRZhqUUN3ME2yNk4zPzh7IN88US=>	NIfKXnZUSU6JRWK=
LS-411N	M4DVZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPud5lKSzVyPUKyMlI5PjlizszN	NVTEWGltW0GQR1XS
no-10	NFjKWJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M320b2lEPTB;MkKuOVAxPCEQvF2=	NX;OT\|JjW0GQR1XS
MKN7	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Moq0TWM2OD1{Mj62PFch\|ryP	MYrTRW5ITVJ?
AU565	NUXBRXVxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFrTdodKSzVyPUKyMlc1PzhizszN	MoH5V2FPT0WU
NUGC-3	NFniclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFzIOpNKSzVyPUKzMlEyQTlizszN	M3mxc3NCVkeHUh?=
EW-16	Mo\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFH4TZRKSzVyPUK0MlA6OjZizszN	MXnTRW5ITVJ?
HCC70	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3TGT2lEPTB;MkSuNVMzOyEQvF2=	NGTlSpdUSU6JRWK=
RPMI-8226	M{TYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHz6fYtKSzVyPUK0MlMyPTVizszN	MVPTRW5ITVJ?
CFPAC-1	Mnn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rnfGlEPTB;MkSuOlI4OiEQvF2=	M{XTVXNCVkeHUh?=
DoTc2-4510	M{jG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYnmTmg2UUN3ME2yOE44PTd3IN88US=>	NYHubWp[W0GQR1XS
KNS-62	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHr3b\|lKSzVyPUK1MlAyQCEQvF2=	NYq3b4tmW0GQR1XS
SK-N-DZ	M4r3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmfhTWM2OD1{NT6wPVA1KM7:TR?=	NW\TcVg3W0GQR1XS
CAL-85-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUDzNnBkUUN3ME2yOU4yPTR2IN88US=>	M4jTXnNCVkeHUh?=
JVM-2	M1\EXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUG2cohqUUN3ME2yOU4zOTJ{IN88US=>	M{POVXNCVkeHUh?=
NCI-H2347	NVXIO\|BuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zYXmlEPTB;MkWuOFI1QSEQvF2=	NHPwRZdUSU6JRWK=
P30-OHK	M2H5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYnHb\|B[UUN3ME2yOU43OzF6IN88US=>	NUnMPWM{W0GQR1XS
SK-N-FI	NXPRUVQxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2WzUWlEPTB;Mk[uNVE3OiEQvF2=	M{nTcnNCVkeHUh?=
CAMA-1	NFvlVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mon1TWM2OD1{Nj60PFc3KM7:TR?=	M{m4XHNCVkeHUh?=
MHH-NB-11	M2LoSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUPXOXV7UUN3ME2yOk42QDVzIN88US=>	MljrV2FPT0WU
IST-MEL1	M3S4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mnv0TWM2OD1{Nj63NVc4KM7:TR?=	NV7sdoU5W0GQR1XS
KARPAS-299	NHfFUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWHJR\|UxRTJ5LkS3NFEh\|ryP	NWryW2U6W0GQR1XS
TE-11	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MY\JR\|UxRTJ5LkezOFIh\|ryP	MUjTRW5ITVJ?
769-P	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXTLOFQ2UUN3ME2yPE41PTN\|IN88US=>	NHPJU5hUSU6JRWK=
CAL-72	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTJ6LkW1OlEh\|ryP	NVTseGhUW0GQR1XS
NCI-H2342	MmHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn;0TWM2OD1{OT6zPFA{KM7:TR?=	MYLTRW5ITVJ?
NCI-H1651	M1vaRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mlq0TWM2OD1{OT64OVA{KM7:TR?=	NUj2bVBiW0GQR1XS
OE33	M{fqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1;5XWlEPTB;M{CuNVM1OiEQvF2=	NEHIO3JUSU6JRWK=
HuP-T4	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVvjPGdyUUN3ME2zNU41QDN5IN88US=>	MWnTRW5ITVJ?
U-118-MG	M2PIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYLTUIttUUN3ME2zNk42PDRzIN88US=>	Ml\yV2FPT0WU
SN12C	MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vhNmlEPTB;M{KuPFgyPSEQvF2=	NIHvfnpUSU6JRWK=
TE-5	M{Pvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3RTWM2OD1\|Mz6xN\|Y5KM7:TR?=	MojxV2FPT0WU
KM-H2	Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWW2fYpvUUN3ME2zN{4yPjl7IN88US=>	NVrzbHZkW0GQR1XS
OVCAR-3	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYrJR\|UxRTN\|LkSxNlch\|ryP	NFvZZVVUSU6JRWK=
NCI-H1304	NWnZNY1xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYeyU5BSUUN3ME2zN{43ODN4IN88US=>	MkXOV2FPT0WU
LU-135	NIXwfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NW\oZ\|E{UUN3ME2zN{44ODh4IN88US=>	NIq0dW1USU6JRWK=
S-117	NV7KXJQxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MW\JR\|UxRTN\|LkeyPFYh\|ryP	NXGy[FR{W0GQR1XS
NCI-H1755	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYHpeoNlUUN3ME2zN{45OTFizszN	NHfiT5JUSU6JRWK=
Mo-T	NEfDN3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF7HVHhKSzVyPUOzMlg2QTNizszN	NV3qZ\|BDW0GQR1XS
SK-OV-3	MlrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vNNWlEPTB;M{OuPFg2PCEQvF2=	NFH5S4pUSU6JRWK=
RCC10RGB	NFXmUIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlLwTWM2OD1\|Mz65OFM{KM7:TR?=	MoWwV2FPT0WU
COLO-680N	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NETCUoZKSzVyPUO0MlE{QTdizszN	NUfPdW5NW0GQR1XS
KURAMOCHI	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4fTe2lEPTB;M{SuOlQzPSEQvF2=	NG\KSodUSU6JRWK=
NCI-H661	M3vpXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkD3TWM2OD1\|ND64OFQ5KM7:TR?=	MXLTRW5ITVJ?
YAPC	NIjEcoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoDpTWM2OD1\|NT65OVM{KM7:TR?=	NXzYWmo4W0GQR1XS
NCI-H526	NGPv[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRTN5LkK3O\|Ih\|ryP	M3qzPHNCVkeHUh?=
A498	NH7CR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2fBW2lEPTB;M{iuNFk2PCEQvF2=	NYnXd5F7W0GQR1XS
VMRC-RCZ	MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFflbYtKSzVyPUO5MlAxPTRizszN	MVnTRW5ITVJ?
HCT-116	NX7TemllT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIPSeIFKSzVyPUO5MlA2QCEQvF2=	MXHTRW5ITVJ?
COLO-320-HSR	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVXKe4YyUUN3ME20NE4xPDFizszN	MmnVV2FPT0WU
OAW-42	NXyyS4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTRyLkC1OFIh\|ryP	M3Tte3NCVkeHUh?=
SK-MEL-1	NVrLWpFIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1H4cWlEPTB;NECuNlkzPyEQvF2=	M3;HVnNCVkeHUh?=
IST-MES1	NVjLfZJuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnPmTWM2OD12MD63OlU{KM7:TR?=	NF;T[WFUSU6JRWK=
CP50-MEL-B	MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYPJR\|UxRTRzLkC3PVch\|ryP	M3u3RnNCVkeHUh?=
RMG-I	MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlzHTWM2OD12Mj60PVIyKM7:TR?=	MlX3V2FPT0WU
D-336MG	NGTydXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGWxb4xKSzVyPUSzMlEyPTJizszN	M2eyZnNCVkeHUh?=
SHP-77	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVn4XXJ2UUN3ME20N{4yQDJ6IN88US=>	Ml;aV2FPT0WU
SW872	NYXYRWJoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M37iZWlEPTB;NEOuNlEzOyEQvF2=	MYfTRW5ITVJ?
DBTRG-05MG	MnP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkHNTWM2OD12ND62PVk3KM7:TR?=	MYrTRW5ITVJ?
COLO-678	MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUnObIZQUUN3ME20OU44ODN{IN88US=>	NUjYSpZyW0GQR1XS
EGI-1	NHXCe2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUDJR\|UxRTR5LkG4N\|Mh\|ryP	M1LYOHNCVkeHUh?=
KYSE-70	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWWyTJkyUUN3ME20O{44OjJ{IN88US=>	NF;0UJFUSU6JRWK=
BALL-1	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVPJR\|UxRTR5LkiyOVQh\|ryP	MWPTRW5ITVJ?
MDA-MB-361	NEnXR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUjU[G5SUUN3ME20PE4xPDZizszN	MofLV2FPT0WU
NCI-H1838	NV7PPHpnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWHHSZExUUN3ME20PE4{PDV6IN88US=>	NGC1[IJUSU6JRWK=
NCI-H1573	MlXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnjQTWM2OD12OD62O\|g2KM7:TR?=	MVTTRW5ITVJ?
HCC1395	M2rvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX[4OYFbUUN3ME20PE46QTJizszN	M2TuZnNCVkeHUh?=
NCI-H2291	NWXhT5B4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2LIcWlEPTB;NEmuOVk5QCEQvF2=	NX\CeXJYW0GQR1XS
RH-18	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXYTWM2OD13MD6wPFg1KM7:TR?=	MmjFV2FPT0WU

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Assay

Methods	Test Index	PMID
Western blot	p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis. p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.	17040210 28415756 25395420
Immunofluorescence	PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei. PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.	25002506
Growth inhibition assay	Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls. Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.	28415756

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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BI-D1870

Cited by 9 Publications

4 Customer Reviews

Purity & Quality Control

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products

Choose Your Country or Region

By Signaling Pathways

By product type

BI-D1870

Cited by 9 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)