BI-D1870

Name: BI-D1870
Brand: Selleck Chemicals
SKU: S2843
Rating: 5 (29 reviews)

For research use only.

Catalog No.S2843

29 publications

CAS No. 501437-28-1

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

Selleck's BI-D1870 has been cited by 29 publications

EMBO Mol Med, 2020, 12(4):e11177

PubMed: 32115889 ( click the link to review the publication )

J Exp Clin Cancer Res, 2020, 39(1):217

PubMed: 33059733 ( click the link to review the publication )

J Cell Sci, 2020, 10.1242/jcs.238295

PubMed: 32122945 ( click the link to review the publication )

Environ Toxicol Pharmacol, 2020, S1382-6689(20)30217-9

PubMed: 33161113 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 521(2):492-498

PubMed: 31677783 ( click the link to review the publication )

Thyroid, 2020, 10.1089/thy.2019.0728

PubMed: 32762307 ( click the link to review the publication )

Cell Mol Life Sci, 2020, 10.1007/s00018-020-03617-5

PubMed: 32804243 ( click the link to review the publication )

Oncotarget, 2020, 11(25):2387-2403

PubMed: 32637030 ( click the link to review the publication )

Emerg Microbes Infect, 2020, 9(1):1748-1760

PubMed: 32691695 ( click the link to review the publication )

Nat Cell Biol, 2019, 21(6):778-790

PubMed: 31160710 ( click the link to review the publication )

Cell Rep, 2019, 26(12):3391-3399

PubMed: 30893610 ( click the link to review the publication )

Antiviral Res, 2019, 170:104572

PubMed: 31376425 ( click the link to review the publication )

J Biol Chem, 2019, 294(27):10530-10543

PubMed: 31126985 ( click the link to review the publication )

Cell Signal, 2019, 63:109362

PubMed: 31344438 ( click the link to review the publication )

Neurourol Urodyn, 2019, 38(6):1504-1516

PubMed: 31033016 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 37(1):135

PubMed: 29970115 ( click the link to review the publication )

Mol Biol Cell, 2018, 29(10):1258-1269

PubMed: 29540532 ( click the link to review the publication )

Nat Chem Biol, 2017, 13(12):1222-1231

PubMed: 28991240 ( click the link to review the publication )

PLoS Pathog, 2017, 13(6):e1006367

PubMed: 28570642 ( click the link to review the publication )

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

Clin Exp Allergy, 2017, 47(4):488-498

PubMed: 28000949 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

Nat Commun, 2016, 7:11971

PubMed: 27321283 ( click the link to review the publication )
Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

J Immunol, 2015, 195(6):2529-39

PubMed: 26276876 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

PLoS Pathog, 2014, 10(6):e1004195

PubMed: 24945302 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoPoTWM2OD1yLkCzOVgh\|ryP	MUPTRW5ITVJ?
H9	MkjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1nWSGlEPTB;MD6wOlAyQSEQvF2=	M3fxWHNCVkeHUh?=
KARPAS-45	MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVqzdVFFUUN3ME2wMlE3PTJ3IN88US=>	NFjL[HpUSU6JRWK=
NCI-H720	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU[2c41EUUN3ME2wMlE4OTl2IN88US=>	NGrte4hUSU6JRWK=
CTV-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXLWPGNIUUN3ME2wMlQ4QDd{IN88US=>	MmGyV2FPT0WU
DU-4475	MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTBwNUC0NVch\|ryP	NUj1VopNW0GQR1XS
A172	MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXXJR\|UxRTBwNUG3NFUh\|ryP	NGnVXHJUSU6JRWK=
EW-18	NUPVW4E5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWfJR\|UxRTBwNkKyNVEh\|ryP	M4LLUXNCVkeHUh?=
KU812	MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYTJR\|UxRTBwNkK2NlMh\|ryP	NFz0cWFUSU6JRWK=
KP-N-YS	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1fsTmlEPTB;MD62PFIzOyEQvF2=	MUHTRW5ITVJ?
SBC-1	MlPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnHITWM2OD1yLk[5OVI1KM7:TR?=	MUHTRW5ITVJ?
ECC10	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmL2TWM2OD1yLkewNFk1KM7:TR?=	M1rKOHNCVkeHUh?=
GAMG	Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4TVXWlEPTB;MD63OFcyPyEQvF2=	MoDJV2FPT0WU
NCI-H209	Ml71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX\lOmFOUUN3ME2wMlc3QDJizszN	NULoNJQzW0GQR1XS
MC-IXC	NVHvRnR2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn32TWM2OD1yLke5OVg6KM7:TR?=	NIC3[oZUSU6JRWK=
HSC-3	M16w[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrxZm1WUUN3ME2wMlgyPzZ7IN88US=>	NFPEPFJUSU6JRWK=
IST-SL1	NEXmTXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHnTPZFKSzVyPUCuPFQ2PzRizszN	M{jQOHNCVkeHUh?=
LU-139	NF3sWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFixdXBKSzVyPUCuPFQ6PThizszN	NUm2N5NiW0GQR1XS
ML-2	NVTHRpVnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M17FWWlEPTB;MD64OVU4PSEQvF2=	M3PzbnNCVkeHUh?=
CAL-62	M1XKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHrMc4RKSzVyPUCuPFgyPTJizszN	MVLTRW5ITVJ?
HL-60	NUDvXo9ET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUT1Ro9mUUN3ME2wMlg5OzZ{IN88US=>	MW\TRW5ITVJ?
KY821	NHzmeY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF35T4FKSzVyPUCuPFg5OTJizszN	M{X2[3NCVkeHUh?=
ES7	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRTBwOUG2NFch\|ryP	M3TVOHNCVkeHUh?=
MV-4-11	M3\Wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUCxcZl[UUN3ME2wMlk4QDl5IN88US=>	MmjoV2FPT0WU
Daoy	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;kTWM2OD1yLkm4O\|Y4KM7:TR?=	NUHVTmRZW0GQR1XS
EoL-1-cell	NFvkdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHzkbnRKSzVyPUGuNFE5PzhizszN	MnTmV2FPT0WU
TGW	MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTFwMEWxNlQh\|ryP	M2LXW3NCVkeHUh?=
LAMA-84	NE\JUZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml7wTWM2OD1zLkGyO\|k1KM7:TR?=	NWH5dWFKW0GQR1XS
KOSC-2	M1jqS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVTNUHI5UUN3ME2xMlE{Ozh3IN88US=>	MWrTRW5ITVJ?
A549	Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX;JR\|UxRTFwM{C5OVUh\|ryP	M3\qe3NCVkeHUh?=
CTB-1	NH;2bndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1PmTmlEPTB;MT60OFY4QSEQvF2=	NFTNTmtUSU6JRWK=
NCI-H292	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHXsR2VKSzVyPUGuOFYxPjlizszN	Mm\HV2FPT0WU
LoVo	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWTJR\|UxRTFwNE[3OVUh\|ryP	M{TzNHNCVkeHUh?=
BFTC-905	NGnkd4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoftTWM2OD1zLkW2N\|MzKM7:TR?=	MVLTRW5ITVJ?
BE-13	NWTkNZRsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M125V2lEPTB;MT61PFcxQSEQvF2=	NXfxdoxMW0GQR1XS
KE-37	MlixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1joe2lEPTB;MT61PVQ4QCEQvF2=	Mo\vV2FPT0WU
HN	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXfJR\|UxRTFwNkGzOlgh\|ryP	NVXDN4xFW0GQR1XS
A3-KAW	Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFfkSY9KSzVyPUGuOlI5OzRizszN	NX;RdYFRW0GQR1XS
NEC8	M1XEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUTZTZprUUN3ME2xMlcxOTF3IN88US=>	NGK5UXVUSU6JRWK=
Ramos-2G6-4C10	M{S1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn3lTWM2OD1zLkewOFQ1KM7:TR?=	M4HwO3NCVkeHUh?=
NB10	M4fVVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fLPWlEPTB;MT63O\|Y{KM7:TR?=	Mkj1V2FPT0WU
NBsusSR	NHTodWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NETnWI1KSzVyPUGuPFI6PjFizszN	MnHtV2FPT0WU
ES4	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIDN[\|dKSzVyPUGuPFUyPDNizszN	NF7FVW5USU6JRWK=
ES8	NEnDd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWPJR\|UxRTFwOEe3NlQh\|ryP	M2PUOnNCVkeHUh?=
CHL-1	M{\BcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{fmWmlEPTB;MT65OVc6OiEQvF2=	NULKb4VQW0GQR1XS
NCI-H2029	M4nke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWXJR\|UxRTFwOUeyOFEh\|ryP	MUfTRW5ITVJ?
YKG-1	M1zBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEfGcopKSzVyPUGuPVg1OzJizszN	MWLTRW5ITVJ?
BV-173	MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mne5TWM2OD1zLkm4OlY3KM7:TR?=	NWroO2dlW0GQR1XS
697	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1jTWWlEPTB;Mj6wNlIzQCEQvF2=	Mnf1V2FPT0WU
SK-NEP-1	NYrETVBxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mly0TWM2OD1{LkC0OEDPxE1?	MWfTRW5ITVJ?
LOXIMVI	M2i0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVfJR\|UxRTJwMES0N\|Qh\|ryP	MXPTRW5ITVJ?
QIMR-WIL	M{naV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2\2[GlEPTB;Mj6wO\|g1QSEQvF2=	M{\N[3NCVkeHUh?=
DU-145	MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4XxWmlEPTB;Mj6xNVA2PiEQvF2=	NF62[4dUSU6JRWK=
NB14	Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTJwMUGzNlEh\|ryP	M2C1XXNCVkeHUh?=
G-361	NXLQdoQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoTGTWM2OD1{LkGyNlEh\|ryP	Mn\mV2FPT0WU
BPH-1	NV3zV3RtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rSOWlEPTB;Mj6xNlk2PyEQvF2=	M{mzeXNCVkeHUh?=
KYSE-150	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTJwMUWyN\|Qh\|ryP	MnS4V2FPT0WU
HMV-II	MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGjnb3hKSzVyPUKuNVY3OzNizszN	MUHTRW5ITVJ?
TE-9	NGnPPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWXJR\|UxRTJwMUezO\|Yh\|ryP	NH\LdXlUSU6JRWK=
8-MG-BA	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEfPZmtKSzVyPUKuNlM1PjFizszN	NU\oN4pwW0GQR1XS
ES5	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWXnSHB2UUN3ME2yMlI{PjN\|IN88US=>	MUTTRW5ITVJ?
D-283MED	NF6zOoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIDBVZNKSzVyPUKuNlM3QTVizszN	MUnTRW5ITVJ?
SK-N-AS	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfWeJRiUUN3ME2yMlI6ODV7IN88US=>	NYfNO4Z1W0GQR1XS
SW1710	M1;DXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkLiTWM2OD1{LkOwOlYyKM7:TR?=	NUfzZmFJW0GQR1XS
GCT	NVyyUlhiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3O0[mlEPTB;Mj6zNVM2QCEQvF2=	MYfTRW5ITVJ?
AGS	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnzvTWM2OD1{LkO0OFA1KM7:TR?=	NYGyfINRW0GQR1XS
HuO9	NXL0VYI5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mk\WTWM2OD1{LkO2PFI1KM7:TR?=	MnvzV2FPT0WU
MN-60	NYK0eVhbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXvJR\|UxRTJwNES4PFMh\|ryP	MX;TRW5ITVJ?
NB6	M3zkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTJwNEW3O\|kh\|ryP	MWLTRW5ITVJ?
NCI-H1395	NIDr[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV\uPHFjUUN3ME2yMlQ4OTJzIN88US=>	M{TGcHNCVkeHUh?=
H4	NFv0fVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV7zcVJyUUN3ME2yMlQ5Ozl\|IN88US=>	NFHYRXZUSU6JRWK=
HT-3	MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYrWOHRXUUN3ME2yMlUyODJ2IN88US=>	M2jQVHNCVkeHUh?=
P12-ICHIKAWA	NVHybVJST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmP1TWM2OD1{LkWyOVU6KM7:TR?=	M{jo[XNCVkeHUh?=
COLO-800	MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlO4TWM2OD1{LkW0NVY3KM7:TR?=	MWDTRW5ITVJ?
DB	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRTJwNUWwNVMh\|ryP	NH;WZ2tUSU6JRWK=
LCLC-97TM1	MlH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTJwNkCwNlgh\|ryP	M{G4bnNCVkeHUh?=
Ca9-22	NFnaNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUL4dJlCUUN3ME2yMlY2QTN\|IN88US=>	MXjTRW5ITVJ?
Becker	Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnPsTWM2OD1{Lk[2NFc5KM7:TR?=	M1fwN3NCVkeHUh?=
ACN	NH;zbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFL6VopKSzVyPUKuOlY4QSEQvF2=	NYDCeolxW0GQR1XS
SJSA-1	MlXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXzJR\|UxRTJwNk[4O{DPxE1?	MXHTRW5ITVJ?
NCI-H1048	M1zEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4TRd2lEPTB;Mj62PFMzOSEQvF2=	M2LjfXNCVkeHUh?=
HEL	Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1PZb2lEPTB;Mj63NFI2PCEQvF2=	NXP1Rlh[W0GQR1XS
NCI-H69	Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7lO\|VKSzVyPUKuO\|E3ODFizszN	NWrRfm14W0GQR1XS
639-V	NF3XNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYix[FRRUUN3ME2yMlcyPzB\|IN88US=>	NGjaXXRUSU6JRWK=
U251	Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHziNGRKSzVyPUKuO\|MxOzJizszN	MlHkV2FPT0WU
NCI-H1792	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3vyVGlEPTB;Mj63N\|c{QCEQvF2=	NEj3SFVUSU6JRWK=
EW-1	NUHYdJZWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoPuTWM2OD1{Lke1N\|I5KM7:TR?=	NVjBW3VYW0GQR1XS
ME-180	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{DnO2lEPTB;Mj63O\|c{PiEQvF2=	MnT3V2FPT0WU
HH	NGDWOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkHXTWM2OD1{LkiwNFAyKM7:TR?=	M3\GWHNCVkeHUh?=
SW954	M1fqNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVfJR\|UxRTJwOEW4N{DPxE1?	MknSV2FPT0WU
SF268	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUXhRVhbUUN3ME2yMlg4OjJ3IN88US=>	NFjG[4FUSU6JRWK=
D-566MG	NWLQ[\|F5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3rdW5bUUN3ME2yMlkyOjl3IN88US=>	NXn4T4Z1W0GQR1XS
EM-2	NF;lUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYXJR\|UxRTJwOUKxPVMh\|ryP	MV3TRW5ITVJ?
NCI-H1299	MnTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M365UWlEPTB;Mj65N\|c{PiEQvF2=	MXTTRW5ITVJ?
PSN1	NHHtXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXTJR\|UxRTNwMEW3PFYh\|ryP	MlfoV2FPT0WU
JVM-3	NX\uS3pvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MU\JR\|UxRTNwME[3OVYh\|ryP	MWPTRW5ITVJ?
D-502MG	M1izN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2rNRmlEPTB;Mz6wO\|AyQSEQvF2=	M3m0XnNCVkeHUh?=
SCC-4	MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV63b3pqUUN3ME2zMlA6Ojd4IN88US=>	NVTT[YZKW0GQR1XS
GMS-10	NV3SSWpUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrs[ZZKSzVyPUOuNFk{QDhizszN	MXfTRW5ITVJ?
A427	Ml3iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH:3WlNKSzVyPUOuNVA5PzNizszN	MYnTRW5ITVJ?
NH-12	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NY\hTFNJUUN3ME2zMlEyPDV4IN88US=>	M{e0TXNCVkeHUh?=
KM12	Mn60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHHoT4tKSzVyPUOuNVIzPzNizszN	M1LPdHNCVkeHUh?=
GI-1	Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn\ZTWM2OD1\|LkG1NlU2KM7:TR?=	NUn6TGY1W0GQR1XS
TE-8	NVv1UJcyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWrJR\|UxRTNwMUmyN\|Eh\|ryP	NHHGNWxUSU6JRWK=
MKN1	M{TLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3K2VmlEPTB;Mz6yNFg4PSEQvF2=	MVTTRW5ITVJ?
NCI-H810	M2LHOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVPJR\|UxRTNwMkKxOVUh\|ryP	Mlj1V2FPT0WU
GOTO	NX6xSYtPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M13WNWlEPTB;Mz6yPFAxPCEQvF2=	NEO2[WtUSU6JRWK=
T98G	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTNwMkiyNVYh\|ryP	NFjS[nNUSU6JRWK=
HD-MY-Z	M{fpdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVm1PWZEUUN3ME2zMlM3PTR{IN88US=>	NV\uSXp{W0GQR1XS
SNU-C2B	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1THZmlEPTB;Mz6zPVA6PyEQvF2=	M{fJT3NCVkeHUh?=
MOLT-4	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVvBfVYyUUN3ME2zMlM6ODl6IN88US=>	NXrXVnZZW0GQR1XS
RPMI-7951	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo\1TWM2OD1\|LkO5O\|Mh\|ryP	NVHzTnRrW0GQR1XS
EW-11	MlTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVnJR\|UxRTNwNEGyNlQh\|ryP	MWPTRW5ITVJ?
RD	M{XsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmDwTWM2OD1\|LkSzNVMzKM7:TR?=	NUnl[3ZMW0GQR1XS
SW48	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml7sTWM2OD1\|LkSzN\|U5KM7:TR?=	MX7TRW5ITVJ?
BB65-RCC	NWPZTGtLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTNwNEWzPVYh\|ryP	MV3TRW5ITVJ?
Ca-Ski	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1;mPWlEPTB;Mz60O\|UyPCEQvF2=	Ml3tV2FPT0WU
CHP-134	NH\VSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mlm4TWM2OD1\|LkS4O\|U5KM7:TR?=	M{H4NnNCVkeHUh?=
CAL-33	MnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nXN2lEPTB;Mz61N\|M3OiEQvF2=	MX\TRW5ITVJ?
TYK-nu	Mlu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTNwNUO2O\|Yh\|ryP	NXHwPJZjW0GQR1XS
LB831-BLC	MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnGTWM2OD1\|LkW0NFE3KM7:TR?=	NIrveGFUSU6JRWK=
KU-19-19	NEDje2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTHN4Q3UUN3ME2zMlYxOzB2IN88US=>	NETk[I9USU6JRWK=
KG-1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTNwNkGxNFYh\|ryP	M1n3[HNCVkeHUh?=
COLO-829	NYHhZXdCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTNwNk[2NVgh\|ryP	NIHDPJRUSU6JRWK=
HUTU-80	M1zBOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn;tTWM2OD1\|Lk[2OlIyKM7:TR?=	M4HiWnNCVkeHUh?=
NCI-H446	MkTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTNwNkizOEDPxE1?	M{TDXXNCVkeHUh?=
LB2241-RCC	M3jUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmC0TWM2OD1\|Lk[4OlI2KM7:TR?=	NXTVW\|U5W0GQR1XS
JEG-3	NFXFTnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTNwNkmxPUDPxE1?	M2j5b3NCVkeHUh?=
LNCaP-Clone-FGC	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUfQSIpqUUN3ME2zMlcxODRzIN88US=>	Mnv2V2FPT0WU
M059J	M1G0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTNwN{G0Olgh\|ryP	M13PcHNCVkeHUh?=
SK-MES-1	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MULJR\|UxRTNwN{OwN{DPxE1?	M1ztXnNCVkeHUh?=
GT3TKB	MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{[1NmlEPTB;Mz63OVYxPCEQvF2=	MnzyV2FPT0WU
DOK	NIPyVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH;t[lZKSzVyPUOuO\|Y2OjZizszN	MkXDV2FPT0WU
HO-1-N-1	NGOzToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MY\JR\|UxRTNwN{m4NFEh\|ryP	M1TBRnNCVkeHUh?=
MZ1-PC	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWDrN5FCUUN3ME2zMlgzQDh\|IN88US=>	M3jlVnNCVkeHUh?=
8305C	NVjnOGpuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH\6c4tKSzVyPUOuPFg6PDNizszN	M3n3eHNCVkeHUh?=
CGTH-W-1	NEHsXGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml\WTWM2OD1\|LkmzOVA1KM7:TR?=	MV3TRW5ITVJ?
LU-134-A	MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWfBbJgzUUN3ME2zMlk2PDJ{IN88US=>	M1zxN3NCVkeHUh?=
C32	NFLmWYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4TPeGlEPTB;Mz65OlU5OSEQvF2=	Mlq0V2FPT0WU
MOLT-13	MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF3jOnBKSzVyPUOuPVY5PTZizszN	NHLDXYhUSU6JRWK=
A375	NGficYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrDUmh4UUN3ME20MlA2OTZ{IN88US=>	M375TXNCVkeHUh?=
CAL-12T	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVKzNJU{UUN3ME20MlA2Pzl3IN88US=>	NGrnToZUSU6JRWK=
IGR-1	M1izO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIC0RnpKSzVyPUSuNVAzPzRizszN	NEX2dXhUSU6JRWK=
LB1047-RCC	M1z0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2XubGlEPTB;ND6xNFQ1OSEQvF2=	NYHHVZJNW0GQR1XS
BHT-101	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXToflZtUUN3ME20MlExPjh\|IN88US=>	NV7pXVlKW0GQR1XS
A431	M2rWW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEnHUJdKSzVyPUSuNVQxQDFizszN	MWPTRW5ITVJ?
EPLC-272H	MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV7JR\|UxRTRwMUe1PVYh\|ryP	NXq1dYs{W0GQR1XS
HT-1376	NF;uUmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmPjTWM2OD12LkKzNFU6KM7:TR?=	NGL1VXZUSU6JRWK=
HCC1954	MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTRwMkW3OFYh\|ryP	NHPuR49USU6JRWK=
KYSE-510	NXXtUYx3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGDKe49KSzVyPUSuNlYxQSEQvF2=	M3ToV3NCVkeHUh?=
PANC-03-27	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFjqVnZKSzVyPUSuN\|AxQDNizszN	NF;QPFNUSU6JRWK=
MDA-MB-157	MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXuwRW1IUUN3ME20MlMxPjV4IN88US=>	NYjJT2p{W0GQR1XS
HOP-62	Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4XxfGlEPTB;ND6zNFg2PiEQvF2=	MYfTRW5ITVJ?
ETK-1	NHXxfVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLEW5BpUUN3ME20MlM3OjB\|IN88US=>	Mn:zV2FPT0WU
MIA-PaCa-2	NXnDdnhjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTRwM{[yNlch\|ryP	MlrEV2FPT0WU
MHH-PREB-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUi5cIVGUUN3ME20MlM6Pzd\|IN88US=>	MX;TRW5ITVJ?
LXF-289	Mm\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGX2RoFKSzVyPUSuOFAzODJizszN	MVjTRW5ITVJ?
ATN-1	M4fFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml7RTWM2OD12LkSyN\|QyKM7:TR?=	NVzZcIpuW0GQR1XS
8505C	MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTRwNEW4NlUh\|ryP	M1fH[XNCVkeHUh?=
HOS	MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEnhT4VKSzVyPUSuOFY1PTNizszN	MYrTRW5ITVJ?
U-266	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVXwRoZNUUN3ME20MlYyODN{IN88US=>	NFf3VnBUSU6JRWK=
5637	MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnnOTWM2OD12Lk[xOFQ1KM7:TR?=	NETxSGZUSU6JRWK=
GCIY	MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1L4PWlEPTB;ND63NVAyPSEQvF2=	M1zpTHNCVkeHUh?=
MDA-MB-231	MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWTJSZJjUUN3ME20MlczOTF3IN88US=>	NFq4[\|RUSU6JRWK=
RKO	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn7VTWM2OD12LkeyPFE4KM7:TR?=	Mkf1V2FPT0WU
COR-L23	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVTJR\|UxRTRwN{SyOVYh\|ryP	Mk\IV2FPT0WU
DJM-1	MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4K5S2lEPTB;ND63PVczQSEQvF2=	Mn\TV2FPT0WU
D-423MG	Mn\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\BdmlEPTB;ND64NFgxOyEQvF2=	MWPTRW5ITVJ?
DMS-114	M4G0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV3JR\|UxRTRwOEGzPFYh\|ryP	NYTyb5FzW0GQR1XS
MHH-ES-1	Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXv0U3N6UUN3ME20MlgzPTB2IN88US=>	M1nq[3NCVkeHUh?=
CAL-51	MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWnJR\|UxRTRwOE[4OFMh\|ryP	MWnTRW5ITVJ?
SW626	NIG3R4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3jh[GlEPTB;ND64PVY6PyEQvF2=	MXHTRW5ITVJ?
COLO-824	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVnVd5p1UUN3ME20MlkxPDB6IN88US=>	NVT6XVN7W0GQR1XS
NCI-H1437	MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWG5U4RuUUN3ME20MlkzQTNizszN	M1HJRnNCVkeHUh?=
CAL-39	MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlLYTWM2OD12LkmzPVg5KM7:TR?=	MX3TRW5ITVJ?
PC-3	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mke3TWM2OD12Lkm0OlQ5KM7:TR?=	MljaV2FPT0WU
A101D	NV\IWItLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWHO[ol1UUN3ME20Mlk3QDZ3IN88US=>	NEHKVopUSU6JRWK=
ES1	NFjNfplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{f4UWlEPTB;NT6wNFE{KM7:TR?=	NX;sRWZFW0GQR1XS
TE-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFvMSHFKSzVyPUWuNFM3PjZizszN	M4jU[nNCVkeHUh?=
KP-N-YN	M{LxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NW\3OVg3UUN3ME21MlA2PjdizszN	NFvkPFNUSU6JRWK=
EFO-27	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFrYSItKSzVyPUWuNFY{OjlizszN	M1HMe3NCVkeHUh?=
BT-549	MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NU\1UXBUUUN3ME21MlA4PzN4IN88US=>	M4\ke3NCVkeHUh?=
HLE	Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoPjTWM2OD13LkGxO\|M1KM7:TR?=	NHz0ZWlUSU6JRWK=
SW982	NHm1fplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkfpTWM2OD13LkGzN\|c1KM7:TR?=	MmXxV2FPT0WU
SCC-25	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmS0TWM2OD13LkG5NFQ3KM7:TR?=	NVflZZFYW0GQR1XS
SK-MEL-28	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF3UZ21KSzVyPUWuNlA{OTNizszN	MXTTRW5ITVJ?
CaR-1	M4jyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYnsWZZyUUN3ME21MlIxPzJ4IN88US=>	MYjTRW5ITVJ?
MLMA	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF;2WIZKSzVyPUWuNlM1OzZizszN	MULTRW5ITVJ?
VM-CUB-1	NYDoZYlnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUDJR\|UxRTVwMkO0N\|kh\|ryP	NIDxUFhUSU6JRWK=
KNS-42	MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MofSTWM2OD13LkK2NVYh\|ryP	MonDV2FPT0WU
TK10	NF7KXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWPJR\|UxRTVwM{[wPFYh\|ryP	M2LwZXNCVkeHUh?=
MEG-01	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV2xU5NmUUN3ME21MlM3Ojd2IN88US=>	NIjNepJUSU6JRWK=
DEL	NIG5cXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHLkTFFKSzVyPUWuN\|kxOjNizszN	MXrTRW5ITVJ?
SJRH30	M1zId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHIdG9YUUN3ME21MlM6OjF\|IN88US=>	Mlr5V2FPT0WU
SK-PN-DW	NF2zdZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHjDT\|lKSzVyPUWuOFM2QDlizszN	NVHke2JYW0GQR1XS
TE-10	NHvMdHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHrFe29KSzVyPUWuOFQ5QTNizszN	NGD0NY9USU6JRWK=
KNS-81-FD	Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYrTTI5YUUN3ME21MlUxODl{IN88US=>	NEnpO4VUSU6JRWK=
BHY	NXi0eYU1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTVwNUGwO{DPxE1?	NWK2ZmxRW0GQR1XS
KYSE-270	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NE[zeJRKSzVyPUWuOVM2OzZizszN	NGjnd\|VUSU6JRWK=
NCI-H650	NWnMTm1qT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnOwTWM2OD13LkW3NVE1KM7:TR?=	Ml;kV2FPT0WU
L-363	NFe2enZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGDhUolKSzVyPUWuOlk1PzZizszN	MULTRW5ITVJ?
TCCSUP	M3vVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDITWM2OD13LkexO\|c5KM7:TR?=	MYnTRW5ITVJ?
SCH	NFjsNZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTVwN{S3Olch\|ryP	MWLTRW5ITVJ?
HTC-C3	M{TiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUT0[4dnUUN3ME21Mlc4PjR2IN88US=>	Mkm1V2FPT0WU
J-RT3-T3-5	M1Tab2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mm\jTWM2OD13LkiwO\|k1KM7:TR?=	NXn2RWJ7W0GQR1XS
Hs-578-T	NWrmNnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn72TWM2OD13LkizOlA4KM7:TR?=	NGDIW2ZUSU6JRWK=
M14	MmrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXXTWM2OD13Lki2O\|I3KM7:TR?=	NWj0b4lzW0GQR1XS
HT-144	NXrFOoFnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV;mR5BXUUN3ME21Mlg3QDN{IN88US=>	MlnwV2FPT0WU
CAL-54	NIO1O4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1PYbWlEPTB;NT65N\|MyPCEQvF2=	M1LJUHNCVkeHUh?=
T47D	M{\US2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MomyTWM2OD13Lkm2NVIh\|ryP	MljzV2FPT0WU
GB-1	NGT4VWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVfJR\|UxRTZwMEKwOlgh\|ryP	NGnjWZZUSU6JRWK=
HSC-2	NV3IT\|B{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4HOdWlEPTB;Nj6xNlM2OyEQvF2=	NYn5eZRZW0GQR1XS
SiHa	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mo\tTWM2OD14LkG0NFk4KM7:TR?=	MYTTRW5ITVJ?
OMC-1	Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1rjdmlEPTB;Nj6zOVQ1OSEQvF2=	NV7Ncno2W0GQR1XS
HGC-27	NILJcIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUTJR\|UxRTZwM{W3PFYh\|ryP	NFO1bYhUSU6JRWK=
FTC-133	NH;wS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX64VZhEUUN3ME22MlQ3PTVzIN88US=>	NELFTVRUSU6JRWK=
KS-1	M1TCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4XCV2lEPTB;Nj61NlE1PyEQvF2=	NFvLcHVUSU6JRWK=
HT-1080	MoPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTZwNUSwOFIh\|ryP	M4XWS3NCVkeHUh?=
SKG-IIIa	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLnTWM2OD14LkW2NlY{KM7:TR?=	NInDc5RUSU6JRWK=
OCUB-M	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTZwNkC3O{DPxE1?	M3jHS3NCVkeHUh?=
MDA-MB-175-VII	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWPCc3N[UUN3ME22MlYzODlizszN	MWjTRW5ITVJ?
BB30-HNC	NXe2VHdHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTZwNke0OFQh\|ryP	M3viTHNCVkeHUh?=
D-542MG	M2\JdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWHJR\|UxRTZwN{OwPUDPxE1?	M{DMR3NCVkeHUh?=
NCI-H2405	NFLpWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH3t[GlKSzVyPU[uO\|Q5PTVizszN	NFXF[lhUSU6JRWK=
SW1573	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWjJR\|UxRTZwN{izNVkh\|ryP	NEf1b2xUSU6JRWK=
NCI-SNU-1	NGHuWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX75VINUUUN3ME22Mlc6ODJ{IN88US=>	MlX5V2FPT0WU
RT-112	Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmLqTWM2OD14Lke5OFY{KM7:TR?=	MVXTRW5ITVJ?
COR-L88	NWH4c2t2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIH6bIFKSzVyPU[uO\|k4QTFizszN	NGXJVIdUSU6JRWK=
SCC-9	Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYe3PJZWUUN3ME22MlgzPTVizszN	MnLmV2FPT0WU
U-87-MG	NGXiSZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV[yWoxtUUN3ME22Mlg{QDJ4IN88US=>	MVHTRW5ITVJ?
Detroit562	NF7yPHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mlr3TWM2OD14Lki1PVkyKM7:TR?=	NGPJNotUSU6JRWK=
LC-2-ad	NWDCNWJNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoOzTWM2OD14Lki2NlkzKM7:TR?=	NUe3UXREW0GQR1XS
IGROV-1	NHTLT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX3NcYptUUN3ME22MlkzPTh\|IN88US=>	NVzoZpNqW0GQR1XS
OVCAR-8	NX3hUnhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYfJR\|UxRTZwOUSyNlkh\|ryP	NWj4PFhVW0GQR1XS
SNU-387	Mnv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTZwOUm1NVYh\|ryP	M3vBbHNCVkeHUh?=
TGBC1TKB	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmXwTWM2OD15LkG1Nlc4KM7:TR?=	NIS0e\|FUSU6JRWK=
NOS-1	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{D0XWlEPTB;Nz6yNFQyPSEQvF2=	M{KzTnNCVkeHUh?=
HEC-1	NHjINYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{HBRmlEPTB;Nz6yOVM5PyEQvF2=	MoDEV2FPT0WU
GI-ME-N	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFzzS3lKSzVyPUeuNlkyPThizszN	MkW0V2FPT0WU
KYSE-520	NE[4fnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4m3NWlEPTB;Nz6yPVI6KM7:TR?=	NV6w[\|REW0GQR1XS
SNU-423	M4Pa[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zNdWlEPTB;Nz6yPVQ2OiEQvF2=	NHPrTlRUSU6JRWK=
C-33-A	Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEDRU2dKSzVyPUeuOFc5OiEQvF2=	MnLlV2FPT0WU
SK-UT-1	Mmj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrXTWJzUUN3ME23MlU1QDJ7IN88US=>	Ml2xV2FPT0WU
OVCAR-4	MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmD3TWM2OD15LkW1NlYh\|ryP	MXrTRW5ITVJ?
KYSE-450	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlT4TWM2OD15Lk[zO\|kyKM7:TR?=	M{fTfXNCVkeHUh?=
RS4-11	MorNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHLZoVPUUN3ME23MlcxOTl4IN88US=>	MlyzV2FPT0WU
OVCAR-5	M3HES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmToTWM2OD15LkiyN\|I6KM7:TR?=	NEPEXnJUSU6JRWK=
K5	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV\JUIx2UUN3ME23Mlg4PDJizszN	MX3TRW5ITVJ?
786-0	MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkH1TWM2OD16LkCzNFk2KM7:TR?=	MYnTRW5ITVJ?
NCI-H747	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXzad20xUUN3ME24MlA1PDV5IN88US=>	M1X0N3NCVkeHUh?=
CAL-27	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYW2c2Z[UUN3ME24MlEzPzJizszN	Mn3mV2FPT0WU
FADU	MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUjGfo5uUUN3ME24MlE4PTR\|IN88US=>	MWPTRW5ITVJ?
SW780	MlrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUXJR\|UxRThwMUi4NlEh\|ryP	M2qzNnNCVkeHUh?=
ACHN	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfFZ2tsUUN3ME24MlIzPTJ7IN88US=>	NVHGUmZRW0GQR1XS
TE-6	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEfafnhKSzVyPUiuNlM4QDhizszN	M4Lt[nNCVkeHUh?=
NCI-H2087	NHjJflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRThwM{[xOVgh\|ryP	Mo\0V2FPT0WU
NCI-H2122	NIHQTFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLyNHdEUUN3ME24MlQxPDd7IN88US=>	NHPqUnJUSU6JRWK=
SK-LU-1	M{S5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7Dbnd{UUN3ME24MlQ{QTl5IN88US=>	NF;JbWtUSU6JRWK=
22RV1	NVj0VGl{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrIT3ZKSzVyPUiuOlE4QDZizszN	MXvTRW5ITVJ?
MEL-JUSO	M3vqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{DXOmlEPTB;OD62PFY4PSEQvF2=	M{LnTnNCVkeHUh?=
UM-UC-3	MlfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1HiUWlEPTB;OD63NVM6KM7:TR?=	NWrnVpB7W0GQR1XS
HuH-7	NGDvbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIn1Um1KSzVyPUiuO\|MxOTJizszN	Mk\BV2FPT0WU
SNU-449	NXjnWZYzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLQT2c5UUN3ME24Mlc2OjZ3IN88US=>	NXHGdpB{W0GQR1XS
RVH-421	M2CzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIDSfohKSzVyPUiuO\|U{QThizszN	MVTTRW5ITVJ?
MFM-223	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MorHTWM2OD16LkiwO\|M2KM7:TR?=	MYXTRW5ITVJ?
CHP-212	M{LlV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;1TWM2OD16LkiyNlY4KM7:TR?=	M1P5N3NCVkeHUh?=
NCI-H28	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRThwOEWxPFUh\|ryP	MoLSV2FPT0WU
C8166	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVTwb3hkUUN3ME24Mlg3Pzd{IN88US=>	NVjqe2tuW0GQR1XS
SCC-15	NWTp[G5vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYXjb4l2UUN3ME24Mlg4OTl4IN88US=>	NYrwTHgzW0GQR1XS
DMS-273	NWrZfJRrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3HObmlEPTB;OD64PVYzOyEQvF2=	NH20S49USU6JRWK=
MPP-89	NX3HWIlZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHv5[FRKSzVyPUiuPVE{PDFizszN	M2rpd3NCVkeHUh?=
EW-22	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHrTWM2OD16LkmxN\|gzKM7:TR?=	MnjzV2FPT0WU
RCM-1	M3;QSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkfrTWM2OD16Lkm2OFg3KM7:TR?=	NF;6cm5USU6JRWK=
BT-474	NV;EW29nT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRThwOUi4O\|Ih\|ryP	NEOxVVFUSU6JRWK=
TI-73	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH31V\|VKSzVyPUmuNFM1QTZizszN	NWTPdm5bW0GQR1XS
ES3	NGG4eohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1rXOGlEPTB;OT6wOVE2PiEQvF2=	MYrTRW5ITVJ?
NB17	M2nlemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTlwMUS1N\|Uh\|ryP	MmHDV2FPT0WU
MOLT-16	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkTZTWM2OD17LkG2OlU2KM7:TR?=	NVPNR3BJW0GQR1XS
TGBC11TKB	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLlTWM2OD17LkG5NlA2KM7:TR?=	NHLvO\|ZUSU6JRWK=
NB12	M3PFS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4PESGlEPTB;OT6zOFA5OSEQvF2=	NYrQOXpnW0GQR1XS
MEL-HO	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYHj[VMzUUN3ME25MlQxOiEQvF2=	M3LJWXNCVkeHUh?=
HuCCT1	NIDM[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXPbINKSzVyPUmuOFc1ODZizszN	M1jOTXNCVkeHUh?=
A704	NGOzOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlTmTWM2OD17LkS3O\|Q2KM7:TR?=	M4HyTHNCVkeHUh?=
SW756	NYPJN24{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUHCO\|Z{UUN3ME25MlU2OzZzIN88US=>	NFvZUZBUSU6JRWK=
SAS	M17KPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkmyTWM2OD17LkW4OFU2KM7:TR?=	MUXTRW5ITVJ?
KINGS-1	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVHJR\|UxRTlwNkmzO{DPxE1?	MYHTRW5ITVJ?
NKM-1	MkfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4LROmlEPTB;OT64N\|k3PCEQvF2=	MlH0V2FPT0WU
C2BBe1	Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkXYTWM2OD17Lki2NlA1KM7:TR?=	Ml\CV2FPT0WU
A204	M4Xsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWX2UY1pUUN3ME25Mlg6PzV3IN88US=>	NWnWcIZrW0GQR1XS
G-401	M3TZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH:2U49KSzVyPUmuPVA1PDlizszN	NHnTbYtUSU6JRWK=
PFSK-1	NIO0elNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mo\uTWM2OD17Lkm1OlY6KM7:TR?=	MV7TRW5ITVJ?
KYSE-410	M33C[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmLVTWM2OD1zMD6wOlE2KM7:TR?=	M3fSSXNCVkeHUh?=
SK-MEL-2	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWr5dphNUUN3ME2xNE4yPTh6IN88US=>	MoDuV2FPT0WU
NB5	Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPlTWM2OD1zMD61OFA2KM7:TR?=	NIm2OXNUSU6JRWK=
NTERA-S-cl-D1	MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{TWfGlEPTB;MUCuOVQ4PSEQvF2=	NUXyeYFbW0GQR1XS
MZ2-MEL	NWL1N3dVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHwNpVIUUN3ME2xNE43PjJizszN	NIDhOGxUSU6JRWK=
SF539	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2O2PWlEPTB;MUCuO\|E5QCEQvF2=	NVrHfHB7W0GQR1XS
CAL-120	NIW4N4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4q3XGlEPTB;MUCuO\|U6PyEQvF2=	M1;BRXNCVkeHUh?=
GR-ST	NX25W3Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH;5OZNKSzVyPUGxMlI6QCEQvF2=	NXW0SoU4W0GQR1XS
IA-LM	NF\IV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXvJR\|UxRTFzLkO0PFYh\|ryP	Mn[yV2FPT0WU
NCI-H2452	NYCy[od6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofqTWM2OD1zMT6zPVI4KM7:TR?=	NWnk[ZhqW0GQR1XS
NCI-H1648	M2jmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnHkTWM2OD1zMT60OlI6KM7:TR?=	MnXXV2FPT0WU
YH-13	NFnHRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmL6TWM2OD1zMT60O\|QzKM7:TR?=	NV\NcpVpW0GQR1XS
NCI-H2228	M4j4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTFzLkS5Nlgh\|ryP	MYHTRW5ITVJ?
LN-405	M2n6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmj3TWM2OD1zMT61PVI4KM7:TR?=	MVrTRW5ITVJ?
647-V	NXv6dmRJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mlm5TWM2OD1zMT61PVc1KM7:TR?=	MUPTRW5ITVJ?
HCC1806	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXvJR\|UxRTFzLk[xN\|Qh\|ryP	M3TIdXNCVkeHUh?=
HPAF-II	M4fOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlHTTWM2OD1zMT64N\|U3KM7:TR?=	NWjL[JZ1W0GQR1XS
BB49-HNC	Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUXXR\|JQUUN3ME2xNU45Ozd3IN88US=>	M4nFenNCVkeHUh?=
KGN	NHH4UFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M37ONGlEPTB;MUGuPFU5QSEQvF2=	NXjLe3NpW0GQR1XS
NOMO-1	M{nL[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4HQR2lEPTB;MUGuPFU6PyEQvF2=	NHv3cmxUSU6JRWK=
A388	NVHZRpdST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHO3[\|dKSzVyPUGxMlg5ODhizszN	NVi1Z\|QxW0GQR1XS
Saos-2	MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4\PUmlEPTB;MUKuNlAxOyEQvF2=	MWTTRW5ITVJ?
SK-HEP-1	MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYnJR\|UxRTF{LkK2NVMh\|ryP	MYjTRW5ITVJ?
HCE-4	M{PYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TZfGlEPTB;MUKuNlY6QSEQvF2=	MlLaV2FPT0WU
NCI-H1581	NGLhc4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGrk[5dKSzVyPUGyMlI5OTlizszN	M2LL[nNCVkeHUh?=
NCI-H23	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWDJWHc1UUN3ME2xNk4{OTJ3IN88US=>	Mn[4V2FPT0WU
NCI-H596	NFvnTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWTJR\|UxRTF{LkS3PVgh\|ryP	MYHTRW5ITVJ?
NB69	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nkPGlEPTB;MUKuO\|U5PSEQvF2=	M1fjcXNCVkeHUh?=
ChaGo-K-1	NGn6RpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLtTWM2OD1zMj63OlQ6KM7:TR?=	MlPsV2FPT0WU
EFM-19	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MorFTWM2OD1zMj63O\|E4KM7:TR?=	NVPnRYl3W0GQR1XS
SW962	MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnTSTWM2OD1zMj64NlI{KM7:TR?=	NVS4dItCW0GQR1XS
KALS-1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYO2[opZUUN3ME2xN{4xQTVizszN	NX\ufWFyW0GQR1XS
MDA-MB-415	Mm[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4HJZmlEPTB;MUOuNVYxQSEQvF2=	M3vqVHNCVkeHUh?=
SW684	NYS4[IJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlnXTWM2OD1zMz6xPFYyKM7:TR?=	M2ruSXNCVkeHUh?=
NCI-H2052	M2rSZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX\JR\|UxRTF\|LkO4OFgh\|ryP	MlWwV2FPT0WU
HOP-92	MkXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlO5TWM2OD1zMz63PVk4KM7:TR?=	MlXuV2FPT0WU
OE19	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIr2VFVKSzVyPUG0MlAxPzVizszN	MkL6V2FPT0WU
D-392MG	M{\Zdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHu3NXFKSzVyPUG0MlEzOTFizszN	MV3TRW5ITVJ?
A253	NW\mcYF1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoXtTWM2OD1zND6yNlUh\|ryP	MoPUV2FPT0WU
NCI-H1155	Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVTQNJRFUUN3ME2xOE4zPzR5IN88US=>	NX3pO2lnW0GQR1XS
SNB75	NHK2WI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYfJR\|UxRTF2LkO4PVMh\|ryP	M{HtZ3NCVkeHUh?=
23132-87	NHS5PWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml;DTWM2OD1zND64N\|U{KM7:TR?=	NEHaOJFUSU6JRWK=
Calu-3	MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn72TWM2OD1zND64O\|Q{KM7:TR?=	MlL5V2FPT0WU
CW-2	MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3ruVmlEPTB;MUWuNFIzOyEQvF2=	NH\Hd4JUSU6JRWK=
COLO-679	NUe2SnR6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXzaWYVRUUN3ME2xOU4yODF\|IN88US=>	NVXjNXVLW0GQR1XS
NCI-SNU-5	NXroUYM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnrSTWM2OD1zNT61OVg6KM7:TR?=	M13lU3NCVkeHUh?=
AN3-CA	M1\rVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYm1TVZjUUN3ME2xOU43PDZ6IN88US=>	NGnicVhUSU6JRWK=
SF126	NWfKNJFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUPrSGhNUUN3ME2xOU44Ojh3IN88US=>	NWnwUWVSW0GQR1XS
D-247MG	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWq1ZlZkUUN3ME2xOU45PTN\|IN88US=>	MULTRW5ITVJ?
UACC-62	NEfPN49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLqTWM2OD1zNT65OlYh\|ryP	NGDTUG1USU6JRWK=
GP5d	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUDDOJZ3UUN3ME2xOk4yOTdzIN88US=>	MoPJV2FPT0WU
HuO-3N1	MmTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHO0[XhKSzVyPUG2MlI1PzNizszN	NF2wTpdUSU6JRWK=
NCI-H1092	M2fremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHudmJqUUN3ME2xOk43Ojl5IN88US=>	NH3TWo5USU6JRWK=
HCC1187	NXLjV4pNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkDmTWM2OD1zNj62OVU4KM7:TR?=	M{\MUXNCVkeHUh?=
G-402	NXjqXXV6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFSzXVlKSzVyPUG2Mlg2PjVizszN	MWHTRW5ITVJ?
HT55	M{PrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFHDS3hKSzVyPUG2Mlg4PTFizszN	NYHOUW97W0GQR1XS
NCI-H2009	NH7yUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MniyTWM2OD1zNj65NlY3KM7:TR?=	Mn34V2FPT0WU
SH-4	M3jwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV63[oFlUUN3ME2xOk46QTJizszN	MmTXV2FPT0WU
SW1783	MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkfaTWM2OD1zNj65PVk5KM7:TR?=	M1fSVHNCVkeHUh?=
HT	MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4ruZmlEPTB;MUeuNVk3PCEQvF2=	Mo[zV2FPT0WU
CP66-MEL	MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXHTWM2OD1zNz6zNFEh\|ryP	NVjpV2hRW0GQR1XS
BEN	NFXrWmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnrXTWM2OD1zNz61OlI3KM7:TR?=	NGD3PW5USU6JRWK=
HCC38	NHnP[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTF5Lke2PVgh\|ryP	M2PNSHNCVkeHUh?=
LAN-6	Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{DXNWlEPTB;MUeuPFQ5PSEQvF2=	MkD1V2FPT0WU
RERF-LC-MS	NIO0W41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXvWPI84UUN3ME2xO{46OTJ7IN88US=>	M4LIPXNCVkeHUh?=
NCI-H1770	MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnrhTWM2OD1zNz65OFkyKM7:TR?=	MlvOV2FPT0WU
LCLC-103H	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;BT4JKSzVyPUG4MlA2OSEQvF2=	NIjQbldUSU6JRWK=
NCI-H520	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nSNGlEPTB;MUiuN\|I5OSEQvF2=	NFfXWWJUSU6JRWK=
LU-65	MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInsZVNKSzVyPUG4MlQxPDNizszN	NXTmSHpKW0GQR1XS
SK-MEL-3	NYfDfVBXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmjFTWM2OD1zOD62Olc6KM7:TR?=	NHny[ldUSU6JRWK=
LK-2	M37Gc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1LENGlEPTB;MUiuO\|czOyEQvF2=	M{T2OXNCVkeHUh?=
PANC-08-13	NV;OUIVjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGTmUW5KSzVyPUG4Mlc5QDlizszN	NYDJW5NGW0GQR1XS
NCI-H460	NHP3fJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX7JR\|UxRTF6Lki0OlYh\|ryP	NV;4UWY{W0GQR1XS
COLO-684	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGe3NYVKSzVyPUG4Mlk6PTZizszN	M3i1UnNCVkeHUh?=
RPMI-2650	NYrMeHRGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV7lTohpUUN3ME2xPU4xOTJizszN	NFrMWJdUSU6JRWK=
NY	M1T5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{nNdWlEPTB;MUmuNVU3PyEQvF2=	NIrGXmtUSU6JRWK=
NB7	MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX3JR\|UxRTF7LkG3OVMh\|ryP	M2XZSnNCVkeHUh?=
NCI-H358	M2flWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPmOo5KSzVyPUG5MlI3PzNizszN	MUTTRW5ITVJ?
MC116	M4nCXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlHITWM2OD1zOT61N\|MyKM7:TR?=	MWLTRW5ITVJ?
MS-1	M4TzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV7JR\|UxRTF7Lk[xNFMh\|ryP	MVfTRW5ITVJ?
NCI-H82	NULTU2ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFXub\|hKSzVyPUG5MlY5PzhizszN	MVTTRW5ITVJ?
OCI-AML2	MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2PTb2lEPTB;MUmuO\|A{OiEQvF2=	M3Hv[nNCVkeHUh?=
LS-123	NFvGeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;uNoxmUUN3ME2yNE4xOTl2IN88US=>	MVzTRW5ITVJ?
PC-14	NFrDd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2DobmlEPTB;MkCuNVg{PCEQvF2=	M3WzUHNCVkeHUh?=
NCI-H1703	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHrQUopKSzVyPUKwMlgyPzNizszN	MofwV2FPT0WU
Calu-6	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mmn1TWM2OD1{MT6xNFA2KM7:TR?=	MVHTRW5ITVJ?
no-11	NXLl[pVXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGLwXpBKSzVyPUKxMlE3ODJizszN	NITWbpNUSU6JRWK=
NCI-H727	NX\nXGVwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\2OIIxUUN3ME2yNU4{PDl\|IN88US=>	Mnj6V2FPT0WU
DSH1	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoLWTWM2OD1{MT6zPFc6KM7:TR?=	NVHQSZJbW0GQR1XS
KYSE-140	NHnvZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUTreYp7UUN3ME2yNU44OjdzIN88US=>	MUjTRW5ITVJ?
RH-1	NFPyOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV7vUHM5UUN3ME2yNU45QDNizszN	MXvTRW5ITVJ?
HAL-01	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYrUWmlkUUN3ME2yNk4xPDF6IN88US=>	NEnZfoFUSU6JRWK=
RXF393	NUj4UI4{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTTbIZEUUN3ME2yNk4zPzh7IN88US=>	M3\wWXNCVkeHUh?=
LS-411N	NWPIPWpmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXzJR\|UxRTJ{LkK4Olkh\|ryP	NXvONWszW0GQR1XS
no-10	NHS3W49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn:wTWM2OD1{Mj61NFA1KM7:TR?=	NV\2OY9FW0GQR1XS
MKN7	MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF3wb2hKSzVyPUKyMlY5PyEQvF2=	MUfTRW5ITVJ?
AU565	NXW2Z4NKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVrJR\|UxRTJ{Lke0O\|gh\|ryP	M4DM[3NCVkeHUh?=
NUGC-3	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDvNI5KSzVyPUKzMlEyQTlizszN	NX;WeINzW0GQR1XS
EW-16	NHe0fFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX\JR\|UxRTJ2LkC5NlYh\|ryP	NWrCc4pGW0GQR1XS
HCC70	MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXHJR\|UxRTJ2LkGzNlMh\|ryP	MnLjV2FPT0WU
RPMI-8226	M{jDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2TJO2lEPTB;MkSuN\|E2PSEQvF2=	NWn1d2tLW0GQR1XS
CFPAC-1	NUX2SJRqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TMbWlEPTB;MkSuOlI4OiEQvF2=	NUjIT21SW0GQR1XS
DoTc2-4510	NG\yVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF65e5NKSzVyPUK0Mlc2PzVizszN	M{LHNXNCVkeHUh?=
KNS-62	MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV\JR\|UxRTJ3LkCxPEDPxE1?	NXK0TYFRW0GQR1XS
SK-N-DZ	MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIW3e5ZKSzVyPUK1MlA6ODRizszN	NHPkT41USU6JRWK=
CAL-85-1	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWSzXoxkUUN3ME2yOU4yPTR2IN88US=>	NYPqOXdrW0GQR1XS
JVM-2	Mkn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYrST5BIUUN3ME2yOU4zOTJ{IN88US=>	MYLTRW5ITVJ?
NCI-H2347	NEPLVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2LmfGlEPTB;MkWuOFI1QSEQvF2=	MXvTRW5ITVJ?
P30-OHK	NGnhfWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoHyTWM2OD1{NT62N\|E5KM7:TR?=	NGe0XHRUSU6JRWK=
SK-N-FI	NH33dIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jXfmlEPTB;Mk[uNVE3OiEQvF2=	Mmm0V2FPT0WU
CAMA-1	MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWDlV21JUUN3ME2yOk41QDd4IN88US=>	MlrSV2FPT0WU
MHH-NB-11	MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGXyT\|JKSzVyPUK2MlU5PTFizszN	MWHTRW5ITVJ?
IST-MEL1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4rh[WlEPTB;Mk[uO\|E4PyEQvF2=	MlvPV2FPT0WU
KARPAS-299	M1ntSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHPmcJRKSzVyPUK3MlQ4ODFizszN	NI\zW3VUSU6JRWK=
TE-11	MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTJ5LkezOFIh\|ryP	NFfGTVRUSU6JRWK=
769-P	NHLmVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\2WFFKSzVyPUK4MlQ2OzNizszN	NGnIOnlUSU6JRWK=
CAL-72	NX;5fnJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIDuOZFKSzVyPUK4MlU2PjFizszN	NEfQZ2tUSU6JRWK=
NCI-H2342	NICxNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH;EfoNKSzVyPUK5MlM5ODNizszN	MVXTRW5ITVJ?
NCI-H1651	Ml\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVHMd2xHUUN3ME2yPU45PTB\|IN88US=>	MnTVV2FPT0WU
OE33	NIP6SIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\xeWlEPTB;M{CuNVM1OiEQvF2=	NHrPOXpUSU6JRWK=
HuP-T4	NUTxdW9OT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFHVZXhKSzVyPUOxMlQ5OzdizszN	NWS2fXVlW0GQR1XS
U-118-MG	NXvZb4poT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIfpVm5KSzVyPUOyMlU1PDFizszN	MVzTRW5ITVJ?
SN12C	MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFzh[WRKSzVyPUOyMlg5OTVizszN	NY\RR3ZCW0GQR1XS
TE-5	NVjwd5RVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjWTWM2OD1\|Mz6xN\|Y5KM7:TR?=	Ml7tV2FPT0WU
KM-H2	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHvLOFBKSzVyPUOzMlE3QTlizszN	M3H0SHNCVkeHUh?=
OVCAR-3	NGLicZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVTJR\|UxRTN\|LkSxNlch\|ryP	Ml;0V2FPT0WU
NCI-H1304	Mm\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUnJR\|UxRTN\|Lk[wN\|Yh\|ryP	M2rVW3NCVkeHUh?=
LU-135	M{PnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoThTWM2OD1\|Mz63NFg3KM7:TR?=	MnPYV2FPT0WU
S-117	NIHiWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVOwTmVbUUN3ME2zN{44Ojh4IN88US=>	M{KwVXNCVkeHUh?=
NCI-H1755	M1z0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTN\|LkixNUDPxE1?	NYHvfI5HW0GQR1XS
Mo-T	NHXMd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1:0d2lEPTB;M{OuPFU6OyEQvF2=	NVLlUllxW0GQR1XS
SK-OV-3	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;hNXVFUUN3ME2zN{45QDV2IN88US=>	MYPTRW5ITVJ?
RCC10RGB	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfybHVkUUN3ME2zN{46PDN\|IN88US=>	Mo\CV2FPT0WU
COLO-680N	NH:xeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGjz[WZKSzVyPUO0MlE{QTdizszN	M3zCeHNCVkeHUh?=
KURAMOCHI	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnf6TWM2OD1\|ND62OFI2KM7:TR?=	M3XLbHNCVkeHUh?=
NCI-H661	MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmDBTWM2OD1\|ND64OFQ5KM7:TR?=	MXHTRW5ITVJ?
YAPC	MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFq0[FRKSzVyPUO1Mlk2OzNizszN	MmrXV2FPT0WU
NCI-H526	M1rBe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX3YeI1WUUN3ME2zO{4zPzd{IN88US=>	Mn3KV2FPT0WU
A498	MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLTVHdKSzVyPUO4MlA6PTRizszN	NFPiZotUSU6JRWK=
VMRC-RCZ	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3TWS2lEPTB;M{muNFA2PCEQvF2=	MWLTRW5ITVJ?
HCT-116	M4rXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTOV2VKSzVyPUO5MlA2QCEQvF2=	MonuV2FPT0WU
COLO-320-HSR	MkHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFjtOldKSzVyPUSwMlA1OSEQvF2=	M{HoeXNCVkeHUh?=
OAW-42	NYHvVYo3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVjjV5V5UUN3ME20NE4xPTR{IN88US=>	M{HJN3NCVkeHUh?=
SK-MEL-1	MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHHINohKSzVyPUSwMlI6OjdizszN	NGTPPJVUSU6JRWK=
IST-MES1	NInvWXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4[wW2lEPTB;NECuO\|Y2OyEQvF2=	NUTGO2JQW0GQR1XS
CP50-MEL-B	M2rWNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWfxOotnUUN3ME20NU4xPzl5IN88US=>	NYDvR3Q4W0GQR1XS
RMG-I	NEjGWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFvpNINKSzVyPUSyMlQ6OjFizszN	MmGxV2FPT0WU
D-336MG	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;6NWlEPTB;NEOuNVE2OiEQvF2=	MmrPV2FPT0WU
SHP-77	M4LzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{nuR2lEPTB;NEOuNVgzQCEQvF2=	M1jUS3NCVkeHUh?=
SW872	NVK4dWpET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIfte3dKSzVyPUSzMlIyOjNizszN	NEmwTphUSU6JRWK=
DBTRG-05MG	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mlv2TWM2OD12ND62PVk3KM7:TR?=	NUHNW5JCW0GQR1XS
COLO-678	M4TNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fUSGlEPTB;NEWuO\|A{OiEQvF2=	MlLkV2FPT0WU
EGI-1	NYjSUoVMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHvzSplKSzVyPUS3MlE5OzNizszN	Mkn1V2FPT0WU
KYSE-70	M2XvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVLJR\|UxRTR5LkeyNlIh\|ryP	M{nj[3NCVkeHUh?=
BALL-1	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;iXIlKSzVyPUS3MlgzPTRizszN	NXi1c4VlW0GQR1XS
MDA-MB-361	MkW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4nDb2lEPTB;NEiuNFQ3KM7:TR?=	MlX4V2FPT0WU
NCI-H1838	MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M37vZWlEPTB;NEiuN\|Q2QCEQvF2=	MnvoV2FPT0WU
NCI-H1573	NIDtRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTR6Lk[3PFUh\|ryP	NGHEUZhUSU6JRWK=
HCC1395	NEDnUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV3K[GtCUUN3ME20PE46QTJizszN	NEjpd5NUSU6JRWK=
NCI-H2291	NXHPN4k3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYPLTXFEUUN3ME20PU42QTh6IN88US=>	MULTRW5ITVJ?
RH-18	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{HHeGlEPTB;NUCuNFg5PCEQvF2=	MYDTRW5ITVJ?

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Assay

Methods	Test Index	PMID
Western blot	p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis. p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.	17040210 28415756 25395420
Immunofluorescence	PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei. PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.	25002506
Growth inhibition assay	Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls. Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.	28415756

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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The Serial Dilution Calculator Equation

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C2=C1/X	C2:	LOG(C2):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

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