BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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Cited by 15 Publications

4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

  • (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

  • Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 M4SyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n0cGlEPTB;MD6wN|U5KM7:TR?= NF\FVoxUSU6JRWK=
H9 NHvpUXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vSPGlEPTB;MD6wOlAyQSEQvF2= NHTIV2xUSU6JRWK=
KARPAS-45 M1PXc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLZTWM2OD1yLkG2OVI2KM7:TR?= NUXU[IN3W0GQR1XS
NCI-H720 NUToR2Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHtTWM2OD1yLkG3NVk1KM7:TR?= MVjTRW5ITVJ?
CTV-1 M3yzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv3TWM2OD1yLkS3PFczKM7:TR?= NFXpd5NUSU6JRWK=
DU-4475 M3;yZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13GV2lEPTB;MD61NFQyPyEQvF2= MmO5V2FPT0WU
A172 M2\6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny0TWM2OD1yLkWxO|A2KM7:TR?= NGHLNG5USU6JRWK=
EW-18 NUm1WW9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{iwUGlEPTB;MD62NlIyOSEQvF2= MYrTRW5ITVJ?
KU812 M3WyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNkK2NlMh|ryP NEKz[XRUSU6JRWK=
KP-N-YS M{nvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLHW5JCUUN3ME2wMlY5OjJ|IN88US=> NEni[3VUSU6JRWK=
SBC-1 NWjWXXl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fUWWlEPTB;MD62PVUzPCEQvF2= M1;HWnNCVkeHUh?=
ECC10 NELBRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nSdmlEPTB;MD63NFA6PCEQvF2= NEHjWHpUSU6JRWK=
GAMG NIXpc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPQeHJKSzVyPUCuO|Q4OTdizszN NGHTNYNUSU6JRWK=
NCI-H209 Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwN{[4NkDPxE1? Ml31V2FPT0WU
MC-IXC NF\XUGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjOTFBKSzVyPUCuO|k2QDlizszN MkS0V2FPT0WU
HSC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3hOodKSzVyPUCuPFE4PjlizszN MWTTRW5ITVJ?
IST-SL1 NVvvbJBNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnicYNDUUN3ME2wMlg1PTd2IN88US=> MljSV2FPT0WU
LU-139 NUTqcIZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW5flhXUUN3ME2wMlg1QTV6IN88US=> MUHTRW5ITVJ?
ML-2 MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP5UFFqUUN3ME2wMlg2PTd3IN88US=> M1vYfHNCVkeHUh?=
CAL-62 NFu2bI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwOEixOVIh|ryP MkH2V2FPT0WU
HL-60 NVLLPHMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn6NoNKSzVyPUCuPFg{PjJizszN M3HuVXNCVkeHUh?=
KY821 NFzDVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3iwOmlEPTB;MD64PFgyOiEQvF2= NIPkO2VUSU6JRWK=
ES7 NYS4eVFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnG2TWM2OD1yLkmxOlA4KM7:TR?= NWC1UYlwW0GQR1XS
MV-4-11 NG\WT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2frUmlEPTB;MD65O|g6PyEQvF2= NF\UfnVUSU6JRWK=
Daoy MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUe3OI9xUUN3ME2wMlk5PzZ5IN88US=> MmHFV2FPT0WU
EoL-1-cell NU\tenVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXJTWM2OD1zLkCxPFc5KM7:TR?= NHm3fZNUSU6JRWK=
TGW Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zJU2lEPTB;MT6wOVEzPCEQvF2= NXOxfFhMW0GQR1XS
LAMA-84 NVPQTZFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XEWGlEPTB;MT6xNlc6PCEQvF2= NFHuO2ZUSU6JRWK=
KOSC-2 NVPTNmdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfQRm1KSzVyPUGuNVM{QDVizszN NFzkeVNUSU6JRWK=
A549 NVPQZWNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTJTFF[UUN3ME2xMlMxQTV3IN88US=> MYPTRW5ITVJ?
CTB-1 NH;YeVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwNES2O|kh|ryP NYPuNm5wW0GQR1XS
NCI-H292 MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;ITWM2OD1zLkS2NFY6KM7:TR?= MXPTRW5ITVJ?
LoVo NULaVm9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3STWM2OD1zLkS2O|U2KM7:TR?= NILTNlhUSU6JRWK=
BFTC-905 NUOwUmp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfRPYZKSzVyPUGuOVY{OzJizszN MnPOV2FPT0WU
BE-13 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFwNUi3NFkh|ryP NGe4clBUSU6JRWK=
KE-37 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:5XGlEPTB;MT61PVQ4QCEQvF2= NXrFS2xEW0GQR1XS
HN MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\FTWM2OD1zLk[xN|Y5KM7:TR?= NF;uOWJUSU6JRWK=
A3-KAW NHHKUlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\Ib4FKSzVyPUGuOlI5OzRizszN NXewR4x6W0GQR1XS
NEC8 M1[0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTFwN{CxNVUh|ryP M1PjT3NCVkeHUh?=
Ramos-2G6-4C10 NFHv[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;vVJZKSzVyPUGuO|A1PDRizszN MUXTRW5ITVJ?
NB10 NF7XV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PsXmlEPTB;MT63O|Y{KM7:TR?= M1OySnNCVkeHUh?=
NBsusSR NFfkVZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjjZ442UUN3ME2xMlgzQTZzIN88US=> MnG1V2FPT0WU
ES4 NGjYSHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTFwOEWxOFMh|ryP MXXTRW5ITVJ?
ES8 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTFwOEe3NlQh|ryP MkO5V2FPT0WU
CHL-1 M{Xxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzER5BKSzVyPUGuPVU4QTJizszN NGLsb5hUSU6JRWK=
NCI-H2029 NVjieXJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj5TWM2OD1zLkm3NlQyKM7:TR?= MUnTRW5ITVJ?
YKG-1 M2Ptemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO0V|lYUUN3ME2xMlk5PDN{IN88US=> M3fCVHNCVkeHUh?=
BV-173 NGTRXI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS2TWM2OD1zLkm4OlY3KM7:TR?= MULTRW5ITVJ?
697 NIPMSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDxfZZKSzVyPUKuNFIzOjhizszN MVfTRW5ITVJ?
SK-NEP-1 M2LIOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzlTWM2OD1{LkC0OEDPxE1? M3THeXNCVkeHUh?=
LOXIMVI NGPLe45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HpU2lEPTB;Mj6wOFQ{PCEQvF2= MkP6V2FPT0WU
QIMR-WIL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWzTWM2OD1{LkC3PFQ6KM7:TR?= NWjrNFlKW0GQR1XS
DU-145 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoO1TWM2OD1{LkGxNFU3KM7:TR?= MYLTRW5ITVJ?
NB14 NGHxdI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDlTWM2OD1{LkGxN|IyKM7:TR?= NUHlUYR1W0GQR1XS
G-361 NFj1eIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\acmlEPTB;Mj6xNlIyKM7:TR?= Mo\IV2FPT0WU
BPH-1 M3\3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXOTWM2OD1{LkGyPVU4KM7:TR?= NUPkfZRwW0GQR1XS
KYSE-150 M4HNO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\vfJhrUUN3ME2yMlE2OjN2IN88US=> NFzMTIpUSU6JRWK=
HMV-II MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n5NGlEPTB;Mj6xOlY{OyEQvF2= NYW4dpREW0GQR1XS
TE-9 M3rQXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXITWM2OD1{LkG3N|c3KM7:TR?= M1v6RnNCVkeHUh?=
8-MG-BA M1vRemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfXb|JKSzVyPUKuNlM1PjFizszN NW\6[lhzW0GQR1XS
ES5 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTwVFZvUUN3ME2yMlI{PjN|IN88US=> NYS0WZVVW0GQR1XS
D-283MED MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LvVmlEPTB;Mj6yN|Y6PSEQvF2= Mn\mV2FPT0WU
SK-N-AS NELDdYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDGcm5KSzVyPUKuNlkxPTlizszN Mn3sV2FPT0WU
SW1710 NGLm[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Htb2lEPTB;Mj6zNFY3OSEQvF2= M1KzZXNCVkeHUh?=
GCT M1nSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELPXZVKSzVyPUKuN|E{PThizszN NXyxZmZ1W0GQR1XS
AGS M1LRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwM{S0NFQh|ryP MnviV2FPT0WU
HuO9 M{DRfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJwM{[4NlQh|ryP NY\hTJUzW0GQR1XS
MN-60 M3LBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnPfplKSzVyPUKuOFQ5QDNizszN Mor3V2FPT0WU
NB6 NF7m[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DpOGlEPTB;Mj60OVc4QSEQvF2= M2fBXnNCVkeHUh?=
NCI-H1395 M2nSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnuRWVuUUN3ME2yMlQ4OTJzIN88US=> NHrPfGtUSU6JRWK=
H4 NYfi[I5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELPdGZKSzVyPUKuOFg{QTNizszN MVLTRW5ITVJ?
HT-3 NF\oVXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELsfGxKSzVyPUKuOVExOjRizszN MXrTRW5ITVJ?
P12-ICHIKAWA M1T1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fEUmlEPTB;Mj61NlU2QSEQvF2= MULTRW5ITVJ?
COLO-800 M{nZ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PUemlEPTB;Mj61OFE3PiEQvF2= MVTTRW5ITVJ?
DB MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwNUWwNVMh|ryP Mmq0V2FPT0WU
LCLC-97TM1 M3vUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrFTWM2OD1{Lk[wNFI5KM7:TR?= NGL1V3JUSU6JRWK=
Ca9-22 NYnHR2RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\aRWxYUUN3ME2yMlY2QTN|IN88US=> MnzhV2FPT0WU
Becker MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwNk[wO|gh|ryP M13LcnNCVkeHUh?=
ACN NFnPbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzITWM2OD1{Lk[2O|kh|ryP M{HHVHNCVkeHUh?=
SJSA-1 M1XITmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PCc2lEPTB;Mj62Olg4KM7:TR?= MlfCV2FPT0WU
NCI-H1048 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPWUWZKSzVyPUKuOlg{OjFizszN NHnGV29USU6JRWK=
HEL MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJwN{CyOVQh|ryP NUDLdXFVW0GQR1XS
NCI-H69 NUXlN4tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoroTWM2OD1{LkexOlAyKM7:TR?= Ml;TV2FPT0WU
639-V Mn7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTJwN{G3NFMh|ryP MmX6V2FPT0WU
U251 NWrx[GZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPGTWM2OD1{LkezNFMzKM7:TR?= M{fIPXNCVkeHUh?=
NCI-H1792 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;idmhVUUN3ME2yMlc{PzN6IN88US=> MkH1V2FPT0WU
EW-1 NH\ydHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nwXGlEPTB;Mj63OVMzQCEQvF2= NHW0eW1USU6JRWK=
ME-180 M{H2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mni2TWM2OD1{Lke3O|M3KM7:TR?= MUHTRW5ITVJ?
HH NUKwZ2RYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mxcmlEPTB;Mj64NFAxOSEQvF2= NUTOeVhUW0GQR1XS
SW954 NUHIRZY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH1TWM2OD1{Lki1PFMh|ryP NFiyV4pUSU6JRWK=
SF268 NYLY[mlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLCXXprUUN3ME2yMlg4OjJ3IN88US=> MVzTRW5ITVJ?
D-566MG M{fLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LkWmlEPTB;Mj65NVI6PSEQvF2= NHHNVJlUSU6JRWK=
EM-2 Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XZTmlEPTB;Mj65NlE6OyEQvF2= NYDaN5BnW0GQR1XS
NCI-H1299 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJwOUO3N|Yh|ryP NUHSVVczW0GQR1XS
PSN1 NWn5dVIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTNwMEW3PFYh|ryP M1nSeHNCVkeHUh?=
JVM-3 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\CWJUyUUN3ME2zMlA3PzV4IN88US=> M2q2NXNCVkeHUh?=
D-502MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwMEewNVkh|ryP MV3TRW5ITVJ?
SCC-4 NVv3Oo1MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTNwMEmyO|Yh|ryP NUX3PG9uW0GQR1XS
GMS-10 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L2fGlEPTB;Mz6wPVM5QCEQvF2= M1\2NnNCVkeHUh?=
A427 NELRZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX4V41KSzVyPUOuNVA5PzNizszN MXjTRW5ITVJ?
NH-12 MoLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;jTWM2OD1|LkGxOFU3KM7:TR?= NI[5R5RUSU6JRWK=
KM12 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrCNnNKSzVyPUOuNVIzPzNizszN MY\TRW5ITVJ?
GI-1 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnKdnN6UUN3ME2zMlE2OjV3IN88US=> MYnTRW5ITVJ?
TE-8 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPsPZpuUUN3ME2zMlE6OjNzIN88US=> M4fHeHNCVkeHUh?=
MKN1 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4SzO2lEPTB;Mz6yNFg4PSEQvF2= NX\XZ3U6W0GQR1XS
NCI-H810 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv6bW5xUUN3ME2zMlIzOTV3IN88US=> NIHTWYtUSU6JRWK=
GOTO MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jzN2lEPTB;Mz6yPFAxPCEQvF2= M2L3WHNCVkeHUh?=
T98G MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P3ZWlEPTB;Mz6yPFIyPiEQvF2= MnjmV2FPT0WU
HD-MY-Z NWPPXGs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TmR2lEPTB;Mz6zOlU1OiEQvF2= NIr5[YhUSU6JRWK=
SNU-C2B NXjmcJp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XhVWlEPTB;Mz6zPVA6PyEQvF2= NX;ER|B7W0GQR1XS
MOLT-4 NY\Nb5hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjROnlWUUN3ME2zMlM6ODl6IN88US=> MWfTRW5ITVJ?
RPMI-7951 NIr4NHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfiW29CUUN3ME2zMlM6PzNizszN M4rsSnNCVkeHUh?=
EW-11 NWf3WXhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDyVnFCUUN3ME2zMlQyOjJ2IN88US=> NI\ITVlUSU6JRWK=
RD MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrITWM2OD1|LkSzNVMzKM7:TR?= NYfI[lZ7W0GQR1XS
SW48 NVe5OItRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLocoE2UUN3ME2zMlQ{OzV6IN88US=> MYDTRW5ITVJ?
BB65-RCC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Tx[mlEPTB;Mz60OVM6PiEQvF2= NYfteVZqW0GQR1XS
Ca-Ski M{LM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXGcHB2UUN3ME2zMlQ4PTF2IN88US=> M2PXTnNCVkeHUh?=
CHP-134 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVqwc41mUUN3ME2zMlQ5PzV6IN88US=> M3jBbnNCVkeHUh?=
CAL-33 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zoUmlEPTB;Mz61N|M3OiEQvF2= NGDMV2tUSU6JRWK=
TYK-nu MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfy[nhKSzVyPUOuOVM3PzZizszN MV3TRW5ITVJ?
LB831-BLC MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljyTWM2OD1|LkW0NFE3KM7:TR?= NITi[HFUSU6JRWK=
KU-19-19 MnjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LJXmlEPTB;Mz62NFMxPCEQvF2= MWjTRW5ITVJ?
KG-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnmyTWM2OD1|Lk[xNVA3KM7:TR?= NX3sUlRZW0GQR1XS
COLO-829 M3vP[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHKRYJKSzVyPUOuOlY3OThizszN M1\aOXNCVkeHUh?=
HUTU-80 M2D4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknNTWM2OD1|Lk[2OlIyKM7:TR?= NYLrfHRCW0GQR1XS
NCI-H446 M{Duc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTNwNkizOEDPxE1? NFHye5ZUSU6JRWK=
LB2241-RCC NY[3eWw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj0dHpKSzVyPUOuOlg3OjVizszN MYHTRW5ITVJ?
JEG-3 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXNTpB2UUN3ME2zMlY6OTlizszN M3TEPXNCVkeHUh?=
LNCaP-Clone-FGC NWPUW|dZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvPbWc4UUN3ME2zMlcxODRzIN88US=> MWfTRW5ITVJ?
M059J M3fFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHzPZRKSzVyPUOuO|E1PjhizszN NF70bWhUSU6JRWK=
SK-MES-1 M3XwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLLTWM2OD1|LkezNFMh|ryP NGjUcYRUSU6JRWK=
GT3TKB NFqxd5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjxU5B5UUN3ME2zMlc2PjB2IN88US=> MXPTRW5ITVJ?
DOK MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYezPWxqUUN3ME2zMlc3PTJ4IN88US=> MlztV2FPT0WU
HO-1-N-1 NGDqe2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHw[ppKSzVyPUOuO|k5ODFizszN M17sR3NCVkeHUh?=
MZ1-PC NUPzT4EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTTfIN5UUN3ME2zMlgzQDh|IN88US=> M1nEVnNCVkeHUh?=
8305C M3PUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwOEi5OFMh|ryP NUfw[2VsW0GQR1XS
CGTH-W-1 NF65c29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXtTWM2OD1|LkmzOVA1KM7:TR?= NIC1W2xUSU6JRWK=
LU-134-A M3zjWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PDZ2lEPTB;Mz65OVQzOiEQvF2= M3W1enNCVkeHUh?=
C32 NUnEOVluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PGVGlEPTB;Mz65OlU5OSEQvF2= NWX5WWdSW0GQR1XS
MOLT-13 MkTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNwOU[4OVYh|ryP MnfaV2FPT0WU
A375 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTRwMEWxOlIh|ryP M3:2V3NCVkeHUh?=
CAL-12T M3OzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jjVmlEPTB;ND6wOVc6PSEQvF2= NHviS5pUSU6JRWK=
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LB1047-RCC NYDDbVNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrifVRKSzVyPUSuNVA1PDFizszN MUHTRW5ITVJ?
BHT-101 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWxdFZKSzVyPUSuNVA3QDNizszN NVzSV4d3W0GQR1XS
A431 M2O2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjmXpJKSzVyPUSuNVQxQDFizszN MknyV2FPT0WU
EPLC-272H MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTRwMUe1PVYh|ryP MYDTRW5ITVJ?
HT-1376 M3jVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTRwMkOwOVkh|ryP NG\jOnBUSU6JRWK=
HCC1954 NGjWW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTRwMkW3OFYh|ryP MVfTRW5ITVJ?
KYSE-510 NH7ocG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nPSmlEPTB;ND6yOlA6KM7:TR?= M3;SXnNCVkeHUh?=
PANC-03-27 MonZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHUdJlOUUN3ME20MlMxODh|IN88US=> M375NXNCVkeHUh?=
MDA-MB-157 NHn1ZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnyxTWM2OD12LkOwOlU3KM7:TR?= MYTTRW5ITVJ?
HOP-62 NFXQTIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfhTWM2OD12LkOwPFU3KM7:TR?= NGGwO4VUSU6JRWK=
ETK-1 NVz6OYpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTRwM{[yNFMh|ryP Mn60V2FPT0WU
MIA-PaCa-2 M4m1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrOTWM2OD12LkO2NlI4KM7:TR?= M3XGWHNCVkeHUh?=
MHH-PREB-1 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrZVpdKSzVyPUSuN|k4PzNizszN MmDuV2FPT0WU
LXF-289 M4jyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jQW2lEPTB;ND60NFIxOiEQvF2= MYDTRW5ITVJ?
ATN-1 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTvTWM2OD12LkSyN|QyKM7:TR?= MVnTRW5ITVJ?
8505C M{H5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTRwNEW4NlUh|ryP MmTYV2FPT0WU
HOS NHnjOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfuTWM2OD12LkS2OFU{KM7:TR?= M{nscXNCVkeHUh?=
U-266 NUH5eHFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDub|Q{UUN3ME20MlYyODN{IN88US=> M1vRWnNCVkeHUh?=
5637 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWryflVMUUN3ME20MlYyPDR2IN88US=> NUmyboNYW0GQR1XS
GCIY NELzcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRwN{GwNVUh|ryP M3K5bXNCVkeHUh?=
MDA-MB-231 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P1UGlEPTB;ND63NlEyPSEQvF2= NIDGcZZUSU6JRWK=
RKO MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfCfYFKSzVyPUSuO|I5OTdizszN Mn;kV2FPT0WU
COR-L23 NHfDZoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;pUW9[UUN3ME20Mlc1OjV4IN88US=> MnfFV2FPT0WU
DJM-1 Mn\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf3PYtKSzVyPUSuO|k4OjlizszN NEDRcHhUSU6JRWK=
D-423MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;l[3FKSzVyPUSuPFA5ODNizszN NX;JXFZ2W0GQR1XS
DMS-114 Ml3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LqbmlEPTB;ND64NVM5PiEQvF2= M2XSXnNCVkeHUh?=
MHH-ES-1 NVjhOph7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DjT2lEPTB;ND64NlUxPCEQvF2= M3TOPXNCVkeHUh?=
CAL-51 MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;oTWM2OD12Lki2PFQ{KM7:TR?= MYjTRW5ITVJ?
SW626 M1f6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\TXJNpUUN3ME20Mlg6Pjl5IN88US=> NIDFSWhUSU6JRWK=
COLO-824 M3zlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHznenpKSzVyPUSuPVA1ODhizszN M1PCRXNCVkeHUh?=
NCI-H1437 NYT4fZNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTRwOUK5N{DPxE1? MkDEV2FPT0WU
CAL-39 NVqwemtkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TJUGlEPTB;ND65N|k5QCEQvF2= M1O0XnNCVkeHUh?=
PC-3 M2CwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTRwOUS2OFgh|ryP Mk[3V2FPT0WU
A101D NHzJT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nINGlEPTB;ND65Olg3PSEQvF2= NW\mNpJpW0GQR1XS
ES1 NIDkXXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPMTooyUUN3ME21MlAxOTNizszN MXPTRW5ITVJ?
TE-1 NWOyXXF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTVwMEO2OlYh|ryP M3f4WnNCVkeHUh?=
KP-N-YN MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTCTWM2OD13LkC1Olch|ryP Ml\KV2FPT0WU
EFO-27 NYPGTWNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTVwME[zNlkh|ryP MXvTRW5ITVJ?
BT-549 NEe2eXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPETJB4UUN3ME21MlA4PzN4IN88US=> NIDyTJFUSU6JRWK=
HLE MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTVwMUG3N|Qh|ryP MlriV2FPT0WU
SW982 NYDvW49kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTVwMUOzO|Qh|ryP M2P2[nNCVkeHUh?=
SCC-25 M1v0fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWxb2tFUUN3ME21MlE6ODR4IN88US=> MlPVV2FPT0WU
SK-MEL-28 M2m1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzqTWM2OD13LkKwN|E{KM7:TR?= M1;FRnNCVkeHUh?=
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MLMA M3G2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13oVWlEPTB;NT6yN|Q{PiEQvF2= NWLWW2k6W0GQR1XS
VM-CUB-1 M3LpTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu5dnJMUUN3ME21MlI{PDN7IN88US=> MYXTRW5ITVJ?
KNS-42 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjmTWM2OD13LkK2NVYh|ryP MVzTRW5ITVJ?
TK10 NIL3ZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDTXoJDUUN3ME21MlM3ODh4IN88US=> NXXkUXZQW0GQR1XS
MEG-01 M2XHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILn[WRKSzVyPUWuN|YzPzRizszN MX;TRW5ITVJ?
DEL NIXDWZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP3cpdKSzVyPUWuN|kxOjNizszN NYX4SGc5W0GQR1XS
SJRH30 NETXXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYX3RVZsUUN3ME21MlM6OjF|IN88US=> NXTqWG5OW0GQR1XS
SK-PN-DW M3HPbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXJTWM2OD13LkSzOVg6KM7:TR?= NHnEXHBUSU6JRWK=
TE-10 NIT1T4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPJenFQUUN3ME21MlQ1QDl|IN88US=> MlTxV2FPT0WU
KNS-81-FD NVjCfodQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTVwNUCwPVIh|ryP MkPoV2FPT0WU
BHY M3fsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTVwNUGwO{DPxE1? NIrTTZZUSU6JRWK=
KYSE-270 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTWTWM2OD13LkWzOVM3KM7:TR?= MmnCV2FPT0WU
NCI-H650 NUHMSFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTVwNUexNVQh|ryP NULsdYdsW0GQR1XS
L-363 NHvrZm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTVwNkm0O|Yh|ryP NGrTTVNUSU6JRWK=
TCCSUP NFHxN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml73TWM2OD13LkexO|c5KM7:TR?= M{S1UHNCVkeHUh?=
SCH MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3XfGNKSzVyPUWuO|Q4PjdizszN NX3GZ4xCW0GQR1XS
HTC-C3 M{nsUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTVwN{e2OFQh|ryP MnjqV2FPT0WU
J-RT3-T3-5 NY\2NohGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDkZW1JUUN3ME21MlgxPzl2IN88US=> NFe5dmlUSU6JRWK=
Hs-578-T MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnUUI5KSzVyPUWuPFM3ODdizszN NFzT[|VUSU6JRWK=
M14 M4[0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fQWmlEPTB;NT64OlczPiEQvF2= NXe0ZVZqW0GQR1XS
HT-144 M2LZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTVwOE[4N|Ih|ryP NWfVUYFEW0GQR1XS
CAL-54 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTVwOUOzNVQh|ryP MUDTRW5ITVJ?
T47D MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX3b49FUUN3ME21Mlk3OTJizszN NUTic|IxW0GQR1XS
GB-1 M1e0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TM[GlEPTB;Nj6wNlA3QCEQvF2= M1;jNnNCVkeHUh?=
HSC-2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\IeI9oUUN3ME22MlEzOzV|IN88US=> NYLYdJVkW0GQR1XS
SiHa MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPpXGxFUUN3ME22MlE1ODl5IN88US=> MX7TRW5ITVJ?
OMC-1 NHnPN2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLwTWM2OD14LkO1OFQyKM7:TR?= NUK4UYtOW0GQR1XS
HGC-27 NIT2U2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVN2lEPTB;Nj6zOVc5PiEQvF2= MV7TRW5ITVJ?
FTC-133 M3m3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NED3RoFKSzVyPU[uOFY2PTFizszN MWTTRW5ITVJ?
KS-1 MoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnSbGk5UUN3ME22MlUzOTR5IN88US=> MXjTRW5ITVJ?
HT-1080 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vhTGlEPTB;Nj61OFA1OiEQvF2= NIDueYJUSU6JRWK=
SKG-IIIa MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3DSmcxUUN3ME22MlU3OjZ|IN88US=> NFry[3hUSU6JRWK=
OCUB-M M1rRN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTOVpRKSzVyPU[uOlA4PyEQvF2= NWHMc2lyW0GQR1XS
MDA-MB-175-VII NGDGfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jqRmlEPTB;Nj62NlA6KM7:TR?= NWj0NopHW0GQR1XS
BB30-HNC MnuzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[4XIRjUUN3ME22MlY4PDR2IN88US=> M2m2bHNCVkeHUh?=
D-542MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL6bIxKSzVyPU[uO|MxQSEQvF2= M{T1V3NCVkeHUh?=
NCI-H2405 NXLxfYtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTZwN{S4OVUh|ryP Mnq2V2FPT0WU
SW1573 NUHwWFNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWyTWM2OD14Lke4N|E6KM7:TR?= NYP3NoFJW0GQR1XS
NCI-SNU-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjzU|lpUUN3ME22Mlc6ODJ{IN88US=> NV7IVJl1W0GQR1XS
RT-112 NVT1W2I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:xNIlKSzVyPU[uO|k1PjNizszN NHrwco1USU6JRWK=
COR-L88 NYGyfZpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTZwN{m3PVEh|ryP M2n2R3NCVkeHUh?=
SCC-9 NWLi[nJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LqXGlEPTB;Nj64NlU2KM7:TR?= NVzKN4RuW0GQR1XS
U-87-MG NIXqbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rBeWlEPTB;Nj64N|gzPiEQvF2= Ml3zV2FPT0WU
Detroit562 M1facWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\XOlZKSzVyPU[uPFU6QTFizszN MX\TRW5ITVJ?
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NCI-H1770 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF5Lkm0PVEh|ryP M33kTnNCVkeHUh?=
LCLC-103H NUD0U2ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDNXJNKSzVyPUG4MlA2OSEQvF2= NFTRc5VUSU6JRWK=
NCI-H520 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS5TWM2OD1zOD6zNlgyKM7:TR?= MojLV2FPT0WU
LU-65 NUD0Z4c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH1dpZKSzVyPUG4MlQxPDNizszN M2HBbHNCVkeHUh?=
SK-MEL-3 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF6Lk[2O|kh|ryP NUf0[IxxW0GQR1XS
LK-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF6Lke3NlMh|ryP MX7TRW5ITVJ?
PANC-08-13 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnoW4lKSzVyPUG4Mlc5QDlizszN M{PQSnNCVkeHUh?=
NCI-H460 M3LQZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrCNZJKSzVyPUG4Mlg1PjZizszN NW\N[otLW0GQR1XS
COLO-684 M2XNWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HPOWlEPTB;MUiuPVk2PiEQvF2= NWDhZZpVW0GQR1XS
RPMI-2650 MlnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDNSHZoUUN3ME2xPU4xOTJizszN Ml23V2FPT0WU
NY NUjzcFlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLX[WZvUUN3ME2xPU4yPTZ5IN88US=> MkXOV2FPT0WU
NB7 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[0TWM2OD1zOT6xO|U{KM7:TR?= NXvGXHZIW0GQR1XS
NCI-H358 NWW2fHFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nJOGlEPTB;MUmuNlY4OyEQvF2= NYXzNWU5W0GQR1XS
MC116 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P6RWlEPTB;MUmuOVM{OSEQvF2= MXTTRW5ITVJ?
MS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13keGlEPTB;MUmuOlExOyEQvF2= MlrnV2FPT0WU
NCI-H82 NHfoZWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf4PVhbUUN3ME2xPU43QDd6IN88US=> NH65[IlUSU6JRWK=
OCI-AML2 NIDJWHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zibmlEPTB;MUmuO|A{OiEQvF2= Mmn5V2FPT0WU
LS-123 NV2yZZdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnX[4RKSzVyPUKwMlAyQTRizszN MVTTRW5ITVJ?
PC-14 Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHJTWM2OD1{MD6xPFM1KM7:TR?= M4PzTHNCVkeHUh?=
NCI-H1703 NVLWZpRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvSTWM2OD1{MD64NVc{KM7:TR?= NIXacFdUSU6JRWK=
Calu-6 M2ezW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X6O2lEPTB;MkGuNVAxPSEQvF2= M3;ZWHNCVkeHUh?=
no-11 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPZc2NDUUN3ME2yNU4yPjB{IN88US=> MUHTRW5ITVJ?
NCI-H727 NGHkO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJzLkO0PVMh|ryP NWnRTW82W0GQR1XS
DSH1 NHHWbJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvybGdKSzVyPUKxMlM5PzlizszN NYLSeVJRW0GQR1XS
KYSE-140 M2nSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHUcI9KSzVyPUKxMlczPzFizszN NUfVfHZZW0GQR1XS
RH-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJzLki4N{DPxE1? M1P6VXNCVkeHUh?=
HAL-01 M4n4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjlTWM2OD1{Mj6wOFE5KM7:TR?= NUjYbmU5W0GQR1XS
RXF393 NIn0UplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJ{LkK3PFkh|ryP MVLTRW5ITVJ?
LS-411N NGnCOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnyU2p1UUN3ME2yNk4zQDZ7IN88US=> MYfTRW5ITVJ?
no-10 M3TSV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPTNIs3UUN3ME2yNk42ODB2IN88US=> NXv1fGdlW0GQR1XS
MKN7 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvDTWM2OD1{Mj62PFch|ryP MWLTRW5ITVJ?
AU565 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHqyV5hKSzVyPUKyMlc1PzhizszN NXLvbZVFW0GQR1XS
NUGC-3 NFXFV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS3fmVbUUN3ME2yN{4yOTl7IN88US=> NWDaTXpEW0GQR1XS
EW-16 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELwcmdKSzVyPUK0MlA6OjZizszN NVv0SZBxW0GQR1XS
HCC70 Ml3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP6TWM2OD1{ND6xN|I{KM7:TR?= NHXLc3VUSU6JRWK=
RPMI-8226 M1PFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL6NIgxUUN3ME2yOE4{OTV3IN88US=> NGLobHNUSU6JRWK=
CFPAC-1 M2jLVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmiwTWM2OD1{ND62NlczKM7:TR?= NXy3[IZ5W0GQR1XS
DoTc2-4510 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXsPFdLUUN3ME2yOE44PTd3IN88US=> M4TQWnNCVkeHUh?=
KNS-62 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfMT25KSzVyPUK1MlAyQCEQvF2= M4PlSXNCVkeHUh?=
SK-N-DZ MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LR[mlEPTB;MkWuNFkxPCEQvF2= NWKzb3loW0GQR1XS
CAL-85-1 NGf4V2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ3LkG1OFQh|ryP MnPpV2FPT0WU
JVM-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfKUWxoUUN3ME2yOU4zOTJ{IN88US=> NHjQZolUSU6JRWK=
NCI-H2347 NEnLcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXydoJKSzVyPUK1MlQzPDlizszN NYPpPVlpW0GQR1XS
P30-OHK M4XwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3nOlFKSzVyPUK1MlY{OThizszN M2fDN3NCVkeHUh?=
SK-N-FI MontS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLxTWM2OD1{Nj6xNVYzKM7:TR?= NELoTo9USU6JRWK=
CAMA-1 M4foOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fMbWlEPTB;Mk[uOFg4PiEQvF2= NInZO4xUSU6JRWK=
MHH-NB-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nwSWlEPTB;Mk[uOVg2OSEQvF2= NG\UN2dUSU6JRWK=
IST-MEL1 NWD5fG9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy0dpdXUUN3ME2yOk44OTd5IN88US=> NH\2SIVUSU6JRWK=
KARPAS-299 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXEWHVKSzVyPUK3MlQ4ODFizszN NU\NdJQxW0GQR1XS
TE-11 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJ5LkezOFIh|ryP M3vDb3NCVkeHUh?=
769-P NFKyfllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjYU5ZkUUN3ME2yPE41PTN|IN88US=> MnvqV2FPT0WU
CAL-72 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ6LkW1OlEh|ryP NFW1dHFUSU6JRWK=
NCI-H2342 M1nKTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXMdHZKSzVyPUK5MlM5ODNizszN MX3TRW5ITVJ?
NCI-H1651 M{TSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJ7Lki1NFMh|ryP NHW5TZhUSU6JRWK=
OE33 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDSR5F{UUN3ME2zNE4yOzR{IN88US=> MXvTRW5ITVJ?
HuP-T4 M3q2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTNzLkS4N|ch|ryP NUPu[IEzW0GQR1XS
U-118-MG MlizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj2eFFKSzVyPUOyMlU1PDFizszN NVHMXpBUW0GQR1XS
SN12C M{PU[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrmdFk2UUN3ME2zNk45QDF3IN88US=> NH\YV3BUSU6JRWK=
TE-5 M1nsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\POWlEPTB;M{OuNVM3QCEQvF2= NX;kO4ZGW0GQR1XS
KM-H2 M1e3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nKTmlEPTB;M{OuNVY6QSEQvF2= M{DCfXNCVkeHUh?=
OVCAR-3 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVe3SY9CUUN3ME2zN{41OTJ5IN88US=> NGrQdm1USU6JRWK=
NCI-H1304 NUDGe4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTN|Lk[wN|Yh|ryP M3\2S3NCVkeHUh?=
LU-135 M{iyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDw[2VLUUN3ME2zN{44ODh4IN88US=> NILLRo9USU6JRWK=
S-117 M36zXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN|LkeyPFYh|ryP NGXTVYVUSU6JRWK=
NCI-H1755 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrYTWM2OD1|Mz64NVEh|ryP MVjTRW5ITVJ?
Mo-T MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljXTWM2OD1|Mz64OVk{KM7:TR?= NUHoTGxlW0GQR1XS
SK-OV-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXjbJpKSzVyPUOzMlg5PTRizszN MXLTRW5ITVJ?
RCC10RGB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPlTWM2OD1|Mz65OFM{KM7:TR?= MlXRV2FPT0WU
COLO-680N NIrtfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDGS|lGUUN3ME2zOE4yOzl5IN88US=> M1zMbHNCVkeHUh?=
KURAMOCHI MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTN2Lk[0NlUh|ryP MX3TRW5ITVJ?
NCI-H661 MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN2Lki0OFgh|ryP M2rWWXNCVkeHUh?=
YAPC NF75O|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\rTWM2OD1|NT65OVM{KM7:TR?= M4LDV3NCVkeHUh?=
NCI-H526 M3\OUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPFTWM2OD1|Nz6yO|czKM7:TR?= Mk\HV2FPT0WU
A498 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTWeGhmUUN3ME2zPE4xQTV2IN88US=> NU\jc3NxW0GQR1XS
VMRC-RCZ M1;ucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLQTY5NUUN3ME2zPU4xODV2IN88US=> NITadoJUSU6JRWK=
HCT-116 NGPH[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXiXY1SUUN3ME2zPU4xPThizszN NFHIOZdUSU6JRWK=
COLO-320-HSR M{LCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HLdGlEPTB;NECuNFQyKM7:TR?= MYjTRW5ITVJ?
OAW-42 MkPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7WSJJCUUN3ME20NE4xPTR{IN88US=> M1zKdXNCVkeHUh?=
SK-MEL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTRyLkK5Nlch|ryP NIHaSlFUSU6JRWK=
IST-MES1 NWXLU5NxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTRyLke2OVMh|ryP Ml7FV2FPT0WU
CP50-MEL-B MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfrSGZEUUN3ME20NU4xPzl5IN88US=> MWHTRW5ITVJ?
RMG-I MoC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLUTWM2OD12Mj60PVIyKM7:TR?= MomyV2FPT0WU
D-336MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPOO4xCUUN3ME20N{4yOTV{IN88US=> MWDTRW5ITVJ?
SHP-77 NFfE[IxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3VcnExUUN3ME20N{4yQDJ6IN88US=> MYjTRW5ITVJ?
SW872 NEPrOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NES3V5dKSzVyPUSzMlIyOjNizszN MYrTRW5ITVJ?
DBTRG-05MG NEDJbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;JZpQ4UUN3ME20OE43QTl4IN88US=> Ml;TV2FPT0WU
COLO-678 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S1dWlEPTB;NEWuO|A{OiEQvF2= NWXHWo9zW0GQR1XS
EGI-1 M{jIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7Ub2FKSzVyPUS3MlE5OzNizszN MlHyV2FPT0WU
KYSE-70 M{LhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH6wdIVKSzVyPUS3MlczOjJizszN MV;TRW5ITVJ?
BALL-1 MnzuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL2WpFKSzVyPUS3MlgzPTRizszN NX3iO5VGW0GQR1XS
MDA-MB-361 M1zGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTR6LkC0OkDPxE1? NIrEUlVUSU6JRWK=
NCI-H1838 NYnNZXU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjm[IJKSzVyPUS4MlM1PThizszN NInH[4lUSU6JRWK=
NCI-H1573 M13nVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3noTmlEPTB;NEiuOlc5PSEQvF2= NWLLUJZxW0GQR1XS
HCC1395 MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rPRWlEPTB;NEiuPVkzKM7:TR?= NXezSFZtW0GQR1XS
NCI-H2291 M4X2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D2UWlEPTB;NEmuOVk5QCEQvF2= MXHTRW5ITVJ?
RH-18 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrBTWM2OD13MD6wPFg1KM7:TR?= NVfiZnBRW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; 

PubMed: 17040210     


(A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments.

p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; 

PubMed: 28415756     


Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control.

IRF4 / MYC / MCL-1 / PARP ; 

PubMed: 25395420     


(B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.

17040210 28415756 25395420
Immunofluorescence
PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

PDCD4 / F-actin ; 

PubMed: 25002506     


A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.

25002506
Growth inhibition assay
Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

Cell viability; 

PubMed: 28415756     


(D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.

28415756

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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