BI-D1870

Catalog No.S2843

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Cited by 6 Publications

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

4 Customer Reviews

Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

(g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.
HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGP1VmVKSzVyPUCuNFM2QCEQvF2=	MVrTRW5ITVJ?
H9	NXXn[m4zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmDQTWM2OD1yLkC2NFE6KM7:TR?=	MoG2V2FPT0WU
KARPAS-45	NXrjRWVOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;zTWM2OD1yLkG2OVI2KM7:TR?=	NUTxWJJRW0GQR1XS
NCI-H720	MnS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTmTWM2OD1yLkG3NVk1KM7:TR?=	M2\lNHNCVkeHUh?=
CTV-1	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwNEe4O\|Ih\|ryP	M3nHUXNCVkeHUh?=
DU-4475	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjCTWM2OD1yLkWwOFE4KM7:TR?=	MkL1V2FPT0WU
A172	MmHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTBwNUG3NFUh\|ryP	M{\5b3NCVkeHUh?=
EW-18	NHzlSVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnzkTWM2OD1yLk[yNlEyKM7:TR?=	M2i1T3NCVkeHUh?=
KU812	NFrIOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXsTWM2OD1yLk[yOlI{KM7:TR?=	NFPiR4JUSU6JRWK=
KP-N-YS	MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV7JR\|UxRTBwNkiyNlMh\|ryP	MV\TRW5ITVJ?
SBC-1	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXTJR\|UxRTBwNkm1NlQh\|ryP	NF\h[mpUSU6JRWK=
ECC10	M3u4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mk[4TWM2OD1yLkewNFk1KM7:TR?=	NI\OeZRUSU6JRWK=
GAMG	NHnaeW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nJW2lEPTB;MD63OFcyPyEQvF2=	NXLDUIhpW0GQR1XS
NCI-H209	Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXjJR\|UxRTBwN{[4NkDPxE1?	NW\Xb5BvW0GQR1XS
MC-IXC	Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV3acnpiUUN3ME2wMlc6PTh7IN88US=>	MnjjV2FPT0WU
HSC-3	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXrpZpQ4UUN3ME2wMlgyPzZ7IN88US=>	MULTRW5ITVJ?
IST-SL1	NH63WoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXLJR\|UxRTBwOES1O\|Qh\|ryP	MULTRW5ITVJ?
LU-139	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVzvNohrUUN3ME2wMlg1QTV6IN88US=>	M3;kO3NCVkeHUh?=
ML-2	MnvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUL1SVJHUUN3ME2wMlg2PTd3IN88US=>	NXLoN4t1W0GQR1XS
CAL-62	M122cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnL4TWM2OD1yLki4NVUzKM7:TR?=	MmmxV2FPT0WU
HL-60	M1jQVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVXJR\|UxRTBwOEizOlIh\|ryP	M2joTHNCVkeHUh?=
KY821	NYrCZWprT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXi4c3FkUUN3ME2wMlg5QDF{IN88US=>	NU\nRWtsW0GQR1XS
ES7	M4[0WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVvLVZZuUUN3ME2wMlkyPjB5IN88US=>	M1;1[3NCVkeHUh?=
MV-4-11	NYL4fINvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGjBVWJKSzVyPUCuPVc5QTdizszN	M1HsWXNCVkeHUh?=
Daoy	Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYnMXYhHUUN3ME2wMlk5PzZ5IN88US=>	M2focXNCVkeHUh?=
EoL-1-cell	MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1PQSWlEPTB;MT6wNVg4QCEQvF2=	MmDhV2FPT0WU
TGW	M1zubmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NV;zOJpyUUN3ME2xMlA2OTJ2IN88US=>	M4X6TXNCVkeHUh?=
LAMA-84	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWrJR\|UxRTFwMUK3PVQh\|ryP	MlrRV2FPT0WU
KOSC-2	M1L6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIPFdWNKSzVyPUGuNVM{QDVizszN	NF3OT2xUSU6JRWK=
A549	M{PhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3Pi[GlEPTB;MT6zNFk2PSEQvF2=	NFT2T\|dUSU6JRWK=
CTB-1	MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHnse3BKSzVyPUGuOFQ3PzlizszN	MkX1V2FPT0WU
NCI-H292	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFvodYFKSzVyPUGuOFYxPjlizszN	NV3Pb3RvW0GQR1XS
LoVo	M3TVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWn2[GF7UUN3ME2xMlQ3PzV3IN88US=>	M4q3OHNCVkeHUh?=
BFTC-905	NV\HSnh7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXfYTVdwUUN3ME2xMlU3OzN{IN88US=>	MXzTRW5ITVJ?
BE-13	M3H6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVjJR\|UxRTFwNUi3NFkh\|ryP	M3rESXNCVkeHUh?=
KE-37	NXXhXHFbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTFwNUm0O\|gh\|ryP	NV[zXnpjW0GQR1XS
HN	MnjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGnZXVVKSzVyPUGuOlE{PjhizszN	M1XFc3NCVkeHUh?=
A3-KAW	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTFwNkK4N\|Qh\|ryP	M4faZ3NCVkeHUh?=
NEC8	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M17tbGlEPTB;MT63NFEyPSEQvF2=	M4HFPXNCVkeHUh?=
Ramos-2G6-4C10	M2G2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUnJR\|UxRTFwN{C0OFQh\|ryP	NX3qNXoyW0GQR1XS
NB10	MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjJTWM2OD1zLke3OlMh\|ryP	MnzIV2FPT0WU
NBsusSR	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnvCTWM2OD1zLkiyPVYyKM7:TR?=	MXfTRW5ITVJ?
ES4	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoHITWM2OD1zLki1NVQ{KM7:TR?=	NH\QUmdUSU6JRWK=
ES8	M3jVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYHJR\|UxRTFwOEe3NlQh\|ryP	M{PLPHNCVkeHUh?=
CHL-1	NV7pRYpFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4f2VGlEPTB;MT65OVc6OiEQvF2=	MYfTRW5ITVJ?
NCI-H2029	MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF;6dGhKSzVyPUGuPVczPDFizszN	M4HUcHNCVkeHUh?=
YKG-1	M2CzZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVfWSZhLUUN3ME2xMlk5PDN{IN88US=>	MoPyV2FPT0WU
BV-173	M4XLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVTJR\|UxRTFwOUi2OlYh\|ryP	MUDTRW5ITVJ?
697	NHe4XopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M123fWlEPTB;Mj6wNlIzQCEQvF2=	NETq[\|RUSU6JRWK=
SK-NEP-1	MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnrRTWM2OD1{LkC0OEDPxE1?	NWrrVFIxW0GQR1XS
LOXIMVI	M2KyWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHnTfmhKSzVyPUKuNFQ1OzRizszN	MknOV2FPT0WU
QIMR-WIL	MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3fNfWlEPTB;Mj6wO\|g1QSEQvF2=	Mo[zV2FPT0WU
DU-145	NXfGT4p{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NV3HPFRjUUN3ME2yMlEyODV4IN88US=>	NV:5bZVqW0GQR1XS
NB14	NFTqWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmXwTWM2OD1{LkGxN\|IyKM7:TR?=	NI\we3lUSU6JRWK=
G-361	NYTzWYlZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4TZbmlEPTB;Mj6xNlIyKM7:TR?=	M3r5bXNCVkeHUh?=
BPH-1	M2\rNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEPXO5RKSzVyPUKuNVI6PTdizszN	MX3TRW5ITVJ?
KYSE-150	NVu4[HV3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TzRmlEPTB;Mj6xOVI{PCEQvF2=	MlfjV2FPT0WU
HMV-II	M3u4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{[1RWlEPTB;Mj6xOlY{OyEQvF2=	Ml;HV2FPT0WU
TE-9	MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGXlS5ZKSzVyPUKuNVc{PzZizszN	M2XGcnNCVkeHUh?=
8-MG-BA	NW[1b4VPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFnIRWxKSzVyPUKuNlM1PjFizszN	MlTCV2FPT0WU
ES5	NVX5TWJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXWS3B5UUN3ME2yMlI{PjN\|IN88US=>	NE\ndIpUSU6JRWK=
D-283MED	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFr3XmlKSzVyPUKuNlM3QTVizszN	M4fqfXNCVkeHUh?=
SK-N-AS	NXKxcGx[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYLYTHBsUUN3ME2yMlI6ODV7IN88US=>	MX3TRW5ITVJ?
SW1710	NEm3T2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIjlUYJKSzVyPUKuN\|A3PjFizszN	NUDteHdCW0GQR1XS
GCT	NXrzWllyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH7NNIdKSzVyPUKuN\|E{PThizszN	M1u2dHNCVkeHUh?=
AGS	NY[3R4xNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\TR2dKSzVyPUKuN\|Q1ODRizszN	NFnW[5dUSU6JRWK=
HuO9	NVO1dFh1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVfoPFJ{UUN3ME2yMlM3QDJ2IN88US=>	MV7TRW5ITVJ?
MN-60	NUjIfFNjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYTySGJbUUN3ME2yMlQ1QDh\|IN88US=>	NEL5RphUSU6JRWK=
NB6	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXPJR\|UxRTJwNEW3O\|kh\|ryP	NYKyfYZ5W0GQR1XS
NCI-H1395	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2XrWWlEPTB;Mj60O\|EzOSEQvF2=	NYjhS2RjW0GQR1XS
H4	MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHrWSmlKSzVyPUKuOFg{QTNizszN	M{PnZ3NCVkeHUh?=
HT-3	NXXhW4piT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX3GWJc6UUN3ME2yMlUyODJ2IN88US=>	NGTPRnpUSU6JRWK=
P12-ICHIKAWA	NX:xVo9DT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3HGUmlEPTB;Mj61NlU2QSEQvF2=	Mlq1V2FPT0WU
COLO-800	NVLtPJRkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTJwNUSxOlYh\|ryP	MYXTRW5ITVJ?
DB	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mlr1TWM2OD1{LkW1NFE{KM7:TR?=	NIHzdIJUSU6JRWK=
LCLC-97TM1	NVjY[WxnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mmn6TWM2OD1{Lk[wNFI5KM7:TR?=	NEDvVIhUSU6JRWK=
Ca9-22	NVfHZmQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVvaW3B6UUN3ME2yMlY2QTN\|IN88US=>	MYHTRW5ITVJ?
Becker	NX;GO5o5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jLTWlEPTB;Mj62OlA4QCEQvF2=	NF31[pNUSU6JRWK=
ACN	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MljPTWM2OD1{Lk[2O\|kh\|ryP	MYXTRW5ITVJ?
SJSA-1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3;aOWlEPTB;Mj62Olg4KM7:TR?=	MXHTRW5ITVJ?
NCI-H1048	MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHvLTlNKSzVyPUKuOlg{OjFizszN	M{W5dnNCVkeHUh?=
HEL	NGnPXWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2GwbmlEPTB;Mj63NFI2PCEQvF2=	NUPURWlMW0GQR1XS
NCI-H69	NXf5fohjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFHpN3RKSzVyPUKuO\|E3ODFizszN	NWixOFZvW0GQR1XS
639-V	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3Tse2lEPTB;Mj63NVcxOyEQvF2=	NWPaZlFMW0GQR1XS
U251	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX3WWZRMUUN3ME2yMlc{ODN{IN88US=>	M1TmVHNCVkeHUh?=
NCI-H1792	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFfxeVNKSzVyPUKuO\|M4OzhizszN	MoXGV2FPT0WU
EW-1	MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWHJR\|UxRTJwN{WzNlgh\|ryP	MWHTRW5ITVJ?
ME-180	MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTJwN{e3N\|Yh\|ryP	NUWyUJRxW0GQR1XS
HH	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1[0WmlEPTB;Mj64NFAxOSEQvF2=	NUHwcIdzW0GQR1XS
SW954	M{Toemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLVZ3BRUUN3ME2yMlg2QDNizszN	NYD5dnoxW0GQR1XS
SF268	NF7R[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoDCTWM2OD1{Lki3NlI2KM7:TR?=	NIjzfmdUSU6JRWK=
D-566MG	NGK0RYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWfJR\|UxRTJwOUGyPVUh\|ryP	NELvUW9USU6JRWK=
EM-2	NVjDbldXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoKxTWM2OD1{LkmyNVk{KM7:TR?=	MoTLV2FPT0WU
NCI-H1299	M{TNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MULJR\|UxRTJwOUO3N\|Yh\|ryP	M4PRPHNCVkeHUh?=
PSN1	MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVX6fHNMUUN3ME2zMlA2Pzh4IN88US=>	M1jpUXNCVkeHUh?=
JVM-3	NGDRXHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jSOmlEPTB;Mz6wOlc2PiEQvF2=	Ml;CV2FPT0WU
D-502MG	NFPVNlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTNwMEewNVkh\|ryP	MYHTRW5ITVJ?
SCC-4	NILHVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTNwMEmyO\|Yh\|ryP	NYn3S455W0GQR1XS
GMS-10	NUfQeVl7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4rlR2lEPTB;Mz6wPVM5QCEQvF2=	NIDHZXhUSU6JRWK=
A427	NX\BR2F5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\pdIpKSzVyPUOuNVA5PzNizszN	NGDISJhUSU6JRWK=
NH-12	NXrJZ3lCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmXOTWM2OD1\|LkGxOFU3KM7:TR?=	MXzTRW5ITVJ?
KM12	NE\JSYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWrJR\|UxRTNwMUKyO\|Mh\|ryP	MonVV2FPT0WU
GI-1	M2TYOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4f6UGlEPTB;Mz6xOVI2PSEQvF2=	NFv0VolUSU6JRWK=
TE-8	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmLsTWM2OD1\|LkG5NlMyKM7:TR?=	NHv1cXRUSU6JRWK=
MKN1	Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXXwUIhsUUN3ME2zMlIxQDd3IN88US=>	NV25NVFUW0GQR1XS
NCI-H810	M2ToNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTNwMkKxOVUh\|ryP	NEXIOpVUSU6JRWK=
GOTO	NET1OYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXH2eWZSUUN3ME2zMlI5ODB2IN88US=>	NXHOV29wW0GQR1XS
T98G	M3LSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofTTWM2OD1\|LkK4NlE3KM7:TR?=	M{Tkc3NCVkeHUh?=
HD-MY-Z	M1[2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTNwM{[1OFIh\|ryP	MUXTRW5ITVJ?
SNU-C2B	NXryXYI1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlzyTWM2OD1\|LkO5NFk4KM7:TR?=	MoOxV2FPT0WU
MOLT-4	NXL6SnZKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTNwM{mwPVgh\|ryP	M3nydnNCVkeHUh?=
RPMI-7951	MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYHOOXA6UUN3ME2zMlM6PzNizszN	NHzlTVRUSU6JRWK=
EW-11	MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn\OTWM2OD1\|LkSxNlI1KM7:TR?=	NUPqcm1CW0GQR1XS
RD	M2\2cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2nVZWlEPTB;Mz60N\|E{OiEQvF2=	M2HQc3NCVkeHUh?=
SW48	NELhV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmL4TWM2OD1\|LkSzN\|U5KM7:TR?=	Mki3V2FPT0WU
BB65-RCC	NHfDVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFjLOHRKSzVyPUOuOFU{QTZizszN	NFPmO5dUSU6JRWK=
Ca-Ski	MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mnr1TWM2OD1\|LkS3OVE1KM7:TR?=	M1nETXNCVkeHUh?=
CHP-134	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUTJR\|UxRTNwNEi3OVgh\|ryP	NFfxempUSU6JRWK=
CAL-33	NV\Jc2hET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPrTWM2OD1\|LkWzN\|YzKM7:TR?=	NWPyT2d{W0GQR1XS
TYK-nu	NF;sUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXsW\|RKSzVyPUOuOVM3PzZizszN	M{jxb3NCVkeHUh?=
LB831-BLC	MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlG5TWM2OD1\|LkW0NFE3KM7:TR?=	M{LYWXNCVkeHUh?=
KU-19-19	NFX5bFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoW5TWM2OD1\|Lk[wN\|A1KM7:TR?=	MlztV2FPT0WU
KG-1	NG\DZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVvoOVhuUUN3ME2zMlYyOTB4IN88US=>	MW\TRW5ITVJ?
COLO-829	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUW5Z3E{UUN3ME2zMlY3PjF6IN88US=>	M3L2PHNCVkeHUh?=
HUTU-80	M2HpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVfJR\|UxRTNwNk[2NlEh\|ryP	NEH5co1USU6JRWK=
NCI-H446	M2SwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVfuXpVUUUN3ME2zMlY5OzRizszN	MlHqV2FPT0WU
LB2241-RCC	NUDkWXNnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH6zRXRKSzVyPUOuOlg3OjVizszN	M{e4UnNCVkeHUh?=
JEG-3	M4fNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrteIMyUUN3ME2zMlY6OTlizszN	M3XIWnNCVkeHUh?=
LNCaP-Clone-FGC	MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTNwN{CwOFEh\|ryP	NXm2XpNxW0GQR1XS
M059J	Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF;jSJNKSzVyPUOuO\|E1PjhizszN	NHzNZm5USU6JRWK=
SK-MES-1	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF75XJFKSzVyPUOuO\|MxOyEQvF2=	MXTTRW5ITVJ?
GT3TKB	NGPuOIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\HfWlEPTB;Mz63OVYxPCEQvF2=	MVHTRW5ITVJ?
DOK	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHaTWM2OD1\|Lke2OVI3KM7:TR?=	NW\VTJdJW0GQR1XS
HO-1-N-1	MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3HHWGlEPTB;Mz63PVgxOSEQvF2=	NF\OZWhUSU6JRWK=
MZ1-PC	M3q2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWnJR\|UxRTNwOEK4PFMh\|ryP	MojGV2FPT0WU
8305C	NH;TdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFzCWI9KSzVyPUOuPFg6PDNizszN	MmjPV2FPT0WU
CGTH-W-1	M4\2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{KyPWlEPTB;Mz65N\|UxPCEQvF2=	NVjiWIVUW0GQR1XS
LU-134-A	Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFfKXJBKSzVyPUOuPVU1OjJizszN	Mn\0V2FPT0WU
C32	M3H3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUjtUpU{UUN3ME2zMlk3PThzIN88US=>	MYnTRW5ITVJ?
MOLT-13	NWTIUVFCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnFTItXUUN3ME2zMlk3QDV4IN88US=>	M1:yfnNCVkeHUh?=
A375	NIXYZlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlPXTWM2OD12LkC1NVYzKM7:TR?=	MYHTRW5ITVJ?
CAL-12T	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1PUU2lEPTB;ND6wOVc6PSEQvF2=	NV;XXmpWW0GQR1XS
IGR-1	NFPUc2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIrST3JKSzVyPUSuNVAzPzRizszN	MVzTRW5ITVJ?
LB1047-RCC	NVfl[2xDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYDJR\|UxRTRwMUC0OFEh\|ryP	MYHTRW5ITVJ?
BHT-101	NFG2[\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnj5TWM2OD12LkGwOlg{KM7:TR?=	MVTTRW5ITVJ?
A431	NF3xRXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUXJR\|UxRTRwMUSwPFEh\|ryP	MWTTRW5ITVJ?
EPLC-272H	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3KTWM2OD12LkG3OVk3KM7:TR?=	NIjSZ3pUSU6JRWK=
HT-1376	NUfKPJk{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEXIdXRKSzVyPUSuNlMxPTlizszN	MXrTRW5ITVJ?
HCC1954	NY\R[o9kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTRwMkW3OFYh\|ryP	NYe5[XNHW0GQR1XS
KYSE-510	M1fBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmPxTWM2OD12LkK2NFkh\|ryP	NGDlWnhUSU6JRWK=
PANC-03-27	NHTYTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4T1b2lEPTB;ND6zNFA5OyEQvF2=	NIDqNFdUSU6JRWK=
MDA-MB-157	M4jBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3fn[2lEPTB;ND6zNFY2PiEQvF2=	M4X2PXNCVkeHUh?=
HOP-62	NFrHe3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\yTWM2OD12LkOwPFU3KM7:TR?=	MlvqV2FPT0WU
ETK-1	MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mmm5TWM2OD12LkO2NlA{KM7:TR?=	M3LUSnNCVkeHUh?=
MIA-PaCa-2	NIDzRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4HrSWlEPTB;ND6zOlIzPyEQvF2=	NUDSWYFLW0GQR1XS
MHH-PREB-1	NWfpRVBiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlS1TWM2OD12LkO5O\|c{KM7:TR?=	M3\zUnNCVkeHUh?=
LXF-289	M2\XUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHVTGdbUUN3ME20MlQxOjB{IN88US=>	NEHNSHlUSU6JRWK=
ATN-1	Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYe4fmN3UUN3ME20MlQzOzRzIN88US=>	MVjTRW5ITVJ?
8505C	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDQdnBKSzVyPUSuOFU5OjVizszN	NUXUcYJ2W0GQR1XS
HOS	NH3UflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NITPd3FKSzVyPUSuOFY1PTNizszN	M3\0ZXNCVkeHUh?=
U-266	MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEDqeo1KSzVyPUSuOlExOzJizszN	NGfxZ4ZUSU6JRWK=
5637	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3P1NGlEPTB;ND62NVQ1PCEQvF2=	NEDJS3RUSU6JRWK=
GCIY	MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTRwN{GwNVUh\|ryP	M4GwU3NCVkeHUh?=
MDA-MB-231	NG\Je5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnjTTWM2OD12LkeyNVE2KM7:TR?=	MkPlV2FPT0WU
RKO	NUWyV3NCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVPJR\|UxRTRwN{K4NVch\|ryP	NH2zbGpUSU6JRWK=
COR-L23	NHLHT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nPNGlEPTB;ND63OFI2PiEQvF2=	NFHkWHBUSU6JRWK=
DJM-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWXJR\|UxRTRwN{m3Nlkh\|ryP	MVvTRW5ITVJ?
D-423MG	M1vVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGm0bnBKSzVyPUSuPFA5ODNizszN	NWDQXpBPW0GQR1XS
DMS-114	NUHvcG5pT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHT1cZNKSzVyPUSuPFE{QDZizszN	MVLTRW5ITVJ?
MHH-ES-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkXnTWM2OD12LkiyOVA1KM7:TR?=	Mli2V2FPT0WU
CAL-51	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHfyW\|JKSzVyPUSuPFY5PDNizszN	M3TiTXNCVkeHUh?=
SW626	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHqTWM2OD12Lki5Olk4KM7:TR?=	NHjtO25USU6JRWK=
COLO-824	NYHaOZlQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUG5VJBvUUN3ME20MlkxPDB6IN88US=>	MWHTRW5ITVJ?
NCI-H1437	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYXsUZplUUN3ME20MlkzQTNizszN	M4TIVHNCVkeHUh?=
CAL-39	MnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYjJR\|UxRTRwOUO5PFgh\|ryP	MVPTRW5ITVJ?
PC-3	NGDnTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkPrTWM2OD12Lkm0OlQ5KM7:TR?=	Ml6zV2FPT0WU
A101D	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nZc2lEPTB;ND65Olg3PSEQvF2=	NXvrVHFVW0GQR1XS
ES1	NUfRfnlGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXsVZJZUUN3ME21MlAxOTNizszN	MYjTRW5ITVJ?
TE-1	M3iwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTVwMEO2OlYh\|ryP	NHrIU4hUSU6JRWK=
KP-N-YN	M3XnWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M321b2lEPTB;NT6wOVY4KM7:TR?=	NF34XlNUSU6JRWK=
EFO-27	MlmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYrJR3p5UUN3ME21MlA3OzJ7IN88US=>	MUnTRW5ITVJ?
BT-549	M1LVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVXw[JF6UUN3ME21MlA4PzN4IN88US=>	NFH2PGdUSU6JRWK=
HLE	MnHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUPJR\|UxRTVwMUG3N\|Qh\|ryP	Mlf4V2FPT0WU
SW982	M4iyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYHJR\|UxRTVwMUOzO\|Qh\|ryP	M17WSnNCVkeHUh?=
SCC-25	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTVwMUmwOFYh\|ryP	NFT4dG5USU6JRWK=
SK-MEL-28	M4\NPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGnXdotKSzVyPUWuNlA{OTNizszN	NIjwXFRUSU6JRWK=
CaR-1	M2fHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2PCdmlEPTB;NT6yNFczPiEQvF2=	MnjOV2FPT0WU
MLMA	MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYO1cJVTUUN3ME21MlI{PDN4IN88US=>	MnjyV2FPT0WU
VM-CUB-1	NF3DSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn\6TWM2OD13LkKzOFM6KM7:TR?=	NI\kVJFUSU6JRWK=
KNS-42	NVnSc29UT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\CTWlEPTB;NT6yOlE3KM7:TR?=	NEHaVWpUSU6JRWK=
TK10	MnLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV\JR\|UxRTVwM{[wPFYh\|ryP	NYHGTmxvW0GQR1XS
MEG-01	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnxTWM2OD13LkO2Nlc1KM7:TR?=	NH;0blZUSU6JRWK=
DEL	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoflTWM2OD13LkO5NFI{KM7:TR?=	NHP3No1USU6JRWK=
SJRH30	Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFrTXpNKSzVyPUWuN\|kzOTNizszN	MkT5V2FPT0WU
SK-PN-DW	MmfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmrlTWM2OD13LkSzOVg6KM7:TR?=	Mn73V2FPT0WU
TE-10	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV3JR\|UxRTVwNES4PVMh\|ryP	M{K5XXNCVkeHUh?=
KNS-81-FD	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3H0fGlEPTB;NT61NFA6OiEQvF2=	NWrEcI1TW0GQR1XS
BHY	NWnodVY4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVPlRlJXUUN3ME21MlUyODdizszN	NXPYV4d2W0GQR1XS
KYSE-270	MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFzNNphKSzVyPUWuOVM2OzZizszN	MljWV2FPT0WU
NCI-H650	MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmnVTWM2OD13LkW3NVE1KM7:TR?=	MoDMV2FPT0WU
L-363	Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MofWTWM2OD13Lk[5OFc3KM7:TR?=	NGqwdW9USU6JRWK=
TCCSUP	NF7QPWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGS0NJdKSzVyPUWuO\|E4PzhizszN	M3;ZZnNCVkeHUh?=
SCH	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYG0UHp2UUN3ME21Mlc1PzZ5IN88US=>	M4DnfXNCVkeHUh?=
HTC-C3	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGey[XVKSzVyPUWuO\|c3PDRizszN	MUTTRW5ITVJ?
J-RT3-T3-5	M4LBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4X0XmlEPTB;NT64NFc6PCEQvF2=	NWr0ZZR{W0GQR1XS
Hs-578-T	MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWrJR\|UxRTVwOEO2NFch\|ryP	NX;G[4tTW0GQR1XS
M14	NUX1bmliT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7vXWNzUUN3ME21Mlg3PzJ4IN88US=>	M2\0WXNCVkeHUh?=
HT-144	NYjBfmhqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVTJR\|UxRTVwOE[4N\|Ih\|ryP	MlvxV2FPT0WU
CAL-54	NXP1enNzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn\ZTWM2OD13LkmzN\|E1KM7:TR?=	NXHyVYVOW0GQR1XS
T47D	NHHIOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTVwOU[xNkDPxE1?	NGLqWnNUSU6JRWK=
GB-1	M2TWSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{PEfGlEPTB;Nj6wNlA3QCEQvF2=	MV;TRW5ITVJ?
HSC-2	M4DSNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NY\QVoZVUUN3ME22MlEzOzV\|IN88US=>	MXrTRW5ITVJ?
SiHa	NXO1UHlHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M13Ge2lEPTB;Nj6xOFA6PyEQvF2=	M{TRdHNCVkeHUh?=
OMC-1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoXlTWM2OD14LkO1OFQyKM7:TR?=	NUXZWGh7W0GQR1XS
HGC-27	M2HobWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3T3N2lEPTB;Nj6zOVc5PiEQvF2=	NYS1c3lyW0GQR1XS
FTC-133	NELnSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVX0XHpGUUN3ME22MlQ3PTVzIN88US=>	MYfTRW5ITVJ?
KS-1	NF\LW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4P6eWlEPTB;Nj61NlE1PyEQvF2=	NEfBephUSU6JRWK=
HT-1080	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3HGUmlEPTB;Nj61OFA1OiEQvF2=	NIGzS2hUSU6JRWK=
SKG-IIIa	NHOxdJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3XJemlEPTB;Nj61OlI3OyEQvF2=	NVTLcJAyW0GQR1XS
OCUB-M	MlXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTZwNkC3O{DPxE1?	M{nWT3NCVkeHUh?=
MDA-MB-175-VII	NELzSlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTZwNkKwPUDPxE1?	M1nCSHNCVkeHUh?=
BB30-HNC	NWCxU5N{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGfnSIdKSzVyPU[uOlc1PDRizszN	MmfZV2FPT0WU
D-542MG	MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlLITWM2OD14LkezNFkh\|ryP	NULvWlB3W0GQR1XS
NCI-H2405	M{fD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWTJR\|UxRTZwN{S4OVUh\|ryP	NFKzeY1USU6JRWK=
SW1573	MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV\JR\|UxRTZwN{izNVkh\|ryP	M4LHcnNCVkeHUh?=
NCI-SNU-1	M1LlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH6yWXdKSzVyPU[uO\|kxOjJizszN	M1nqbHNCVkeHUh?=
RT-112	NVTpcmk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTZwN{m0OlMh\|ryP	M1LrV3NCVkeHUh?=
COR-L88	M2TMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUTJR\|UxRTZwN{m3PVEh\|ryP	M4LPXnNCVkeHUh?=
SCC-9	MnHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\ke2lEPTB;Nj64NlU2KM7:TR?=	MUXTRW5ITVJ?
U-87-MG	NIPSW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXOzNG42UUN3ME22Mlg{QDJ4IN88US=>	M2rNS3NCVkeHUh?=
Detroit562	MlnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2fxT2lEPTB;Nj64OVk6OSEQvF2=	NIXY[mdUSU6JRWK=
LC-2-ad	NELLclZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWPTOmFzUUN3ME22Mlg3Ojl{IN88US=>	NXyzdoFpW0GQR1XS
IGROV-1	MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFTOWmhKSzVyPU[uPVI2QDNizszN	NEToTIlUSU6JRWK=
OVCAR-8	NYfBcHE{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2S3cGlEPTB;Nj65OFIzQSEQvF2=	MYPTRW5ITVJ?
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NCI-H747	M{DXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX[4WGl3UUN3ME24MlA1PDV5IN88US=>	MmL4V2FPT0WU
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NCI-H2087	NWjVb2oyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DGeWlEPTB;OD6zOlE2QCEQvF2=	MWnTRW5ITVJ?
NCI-H2122	MlvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVOxZ4NpUUN3ME24MlQxPDd7IN88US=>	MlXVV2FPT0WU
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MEL-JUSO	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGe0TGZKSzVyPUiuOlg3PzVizszN	M1nicHNCVkeHUh?=
UM-UC-3	NF3HbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRThwN{GzPUDPxE1?	MkLFV2FPT0WU
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MFM-223	NWqxTpJpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWTyRnNRUUN3ME24MlgxPzN3IN88US=>	MWjTRW5ITVJ?
CHP-212	MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mmf0TWM2OD16LkiyNlY4KM7:TR?=	NGLJNlhUSU6JRWK=
NCI-H28	NGSxRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkjQTWM2OD16Lki1NVg2KM7:TR?=	M173UXNCVkeHUh?=
C8166	M{GwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVTRbWFFUUN3ME24Mlg3Pzd{IN88US=>	MUXTRW5ITVJ?
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DMS-273	M4K2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIPGUYFKSzVyPUiuPFk3OjNizszN	MojrV2FPT0WU
MPP-89	NXPZT4JPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoTHTWM2OD16LkmxN\|QyKM7:TR?=	Mm\1V2FPT0WU
EW-22	NVjXUWoyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojXTWM2OD16LkmxN\|gzKM7:TR?=	M4D4dHNCVkeHUh?=
RCM-1	MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnezTWM2OD16Lkm2OFg3KM7:TR?=	NVTkUo5jW0GQR1XS
BT-474	NIPjVY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXTScoF4UUN3ME24Mlk5QDd{IN88US=>	NWPqdGNNW0GQR1XS
TI-73	M1XPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIHEdW5KSzVyPUmuNFM1QTZizszN	M{LIPXNCVkeHUh?=
ES3	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVzJR\|UxRTlwMEWxOVYh\|ryP	MY\TRW5ITVJ?
NB17	NHXnOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoP0TWM2OD17LkG0OVM2KM7:TR?=	MYrTRW5ITVJ?
MOLT-16	NUXtZpRwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYPSRpRbUUN3ME25MlE3PjV3IN88US=>	M3LPTXNCVkeHUh?=
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NB12	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUPJR\|UxRTlwM{SwPFEh\|ryP	MWXTRW5ITVJ?
MEL-HO	MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWTjVJl2UUN3ME25MlQxOiEQvF2=	M1jGSXNCVkeHUh?=
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KINGS-1	NULD[lIxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH3G[nNKSzVyPUmuOlk{PyEQvF2=	NWrUZmduW0GQR1XS
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A204	Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYLJR\|UxRTlwOEm3OVUh\|ryP	NHTUO2VUSU6JRWK=
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PFSK-1	M{jVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH30WY9KSzVyPUmuPVU3PjlizszN	NX7jZo9ZW0GQR1XS
KYSE-410	M4eySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXrlTnY2UUN3ME2xNE4xPjF3IN88US=>	Mn;KV2FPT0WU
SK-MEL-2	MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1;M[mlEPTB;MUCuNVU5QCEQvF2=	NWK2cHpEW0GQR1XS
NB5	NFnLbpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYfpW5JGUUN3ME2xNE42PDB3IN88US=>	MXnTRW5ITVJ?
NTERA-S-cl-D1	MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUfrTHoxUUN3ME2xNE42PDd3IN88US=>	NWLCOYREW0GQR1XS
MZ2-MEL	MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{nNWmlEPTB;MUCuOlYzKM7:TR?=	NETTVppUSU6JRWK=
SF539	NUjV[VFlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTFyLkexPFgh\|ryP	NX\ITYlsW0GQR1XS
CAL-120	NIrK[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXtPZFKSzVyPUGwMlc2QTdizszN	NFHGVndUSU6JRWK=
GR-ST	NIHCWVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2CyT2lEPTB;MUGuNlk5KM7:TR?=	MnrnV2FPT0WU
IA-LM	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nibmlEPTB;MUGuN\|Q5PiEQvF2=	NH6zR49USU6JRWK=
NCI-H2452	M2fVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1naW2lEPTB;MUGuN\|kzPyEQvF2=	MVHTRW5ITVJ?
NCI-H1648	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHsTWM2OD1zMT60OlI6KM7:TR?=	M3vpR3NCVkeHUh?=
YH-13	NHy0N2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH60dotKSzVyPUGxMlQ4PDJizszN	NHnQZY1USU6JRWK=
NCI-H2228	NHjYVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWn2d\|VIUUN3ME2xNU41QTJ6IN88US=>	MoLOV2FPT0WU
LN-405	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1;TPWlEPTB;MUGuOVkzPyEQvF2=	NWfPTXVrW0GQR1XS
647-V	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3STWM2OD1zMT61PVc1KM7:TR?=	NV;Gb2M6W0GQR1XS
HCC1806	NVHJUVNZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXfmWZZoUUN3ME2xNU43OTN2IN88US=>	MkTKV2FPT0WU
HPAF-II	Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTFzLkizOVYh\|ryP	M1vkSnNCVkeHUh?=
BB49-HNC	NEK1OHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2X3ZWlEPTB;MUGuPFM4PSEQvF2=	M1HTTHNCVkeHUh?=
KGN	NX7NPWEyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVvPd4g6UUN3ME2xNU45PTh7IN88US=>	MkC5V2FPT0WU
NOMO-1	M1vkSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIDJ[lRKSzVyPUGxMlg2QTdizszN	MWfTRW5ITVJ?
A388	NVvMfGx2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF33S4NKSzVyPUGxMlg5ODhizszN	MoP1V2FPT0WU
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SK-HEP-1	NIXOOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVjJR\|UxRTF{LkK2NVMh\|ryP	MnTsV2FPT0WU
HCE-4	M3vVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTF{LkK2PVkh\|ryP	NYHZTnE1W0GQR1XS
NCI-H1581	M3nSR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3rW[mlEPTB;MUKuNlgyQSEQvF2=	Mn62V2FPT0WU
NCI-H23	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4DJUGlEPTB;MUKuN\|EzPSEQvF2=	MnHtV2FPT0WU
NCI-H596	MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVzs[lZxUUN3ME2xNk41Pzl6IN88US=>	MnKyV2FPT0WU
NB69	NGTvfodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTF{Lke1PFUh\|ryP	M13qTnNCVkeHUh?=
ChaGo-K-1	MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnLLTWM2OD1zMj63OlQ6KM7:TR?=	M1i2ZnNCVkeHUh?=
EFM-19	MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYPyRnJSUUN3ME2xNk44PzF5IN88US=>	M3;qZXNCVkeHUh?=
SW962	M1rTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkTXTWM2OD1zMj64NlI{KM7:TR?=	MlrWV2FPT0WU
KALS-1	Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXPJR\|UxRTF\|LkC5OUDPxE1?	NH7Vc5hUSU6JRWK=
MDA-MB-415	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXHvOVBCUUN3ME2xN{4yPjB7IN88US=>	M{TaOHNCVkeHUh?=
SW684	NFuwZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFHQNXBKSzVyPUGzMlE5PjFizszN	MnXlV2FPT0WU
NCI-H2052	NUKyWZdmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIDyc2RKSzVyPUGzMlM5PDhizszN	MkPSV2FPT0WU
HOP-92	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTF\|Lke5PVch\|ryP	M4SxTnNCVkeHUh?=
OE19	M1PZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVTJR\|UxRTF2LkCwO\|Uh\|ryP	M1jXXnNCVkeHUh?=
D-392MG	NIrNVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4HWNWlEPTB;MUSuNVIyOSEQvF2=	MXTTRW5ITVJ?
A253	NH7wfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX3JR\|UxRTF2LkKyOUDPxE1?	MUPTRW5ITVJ?
NCI-H1155	MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mnm5TWM2OD1zND6yO\|Q4KM7:TR?=	MX\TRW5ITVJ?
SNB75	MmTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4rEbmlEPTB;MUSuN\|g6OyEQvF2=	MlXzV2FPT0WU
23132-87	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTF2LkizOVMh\|ryP	NH75cXlUSU6JRWK=
Calu-3	M4LxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml33TWM2OD1zND64O\|Q{KM7:TR?=	NUXtTFExW0GQR1XS
CW-2	NXT6cpZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTsTWM2OD1zNT6wNlI{KM7:TR?=	M{jpeHNCVkeHUh?=
COLO-679	NVzEWnB{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVnKNGFwUUN3ME2xOU4yODF\|IN88US=>	MUnTRW5ITVJ?
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AN3-CA	NYX1cJFFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXK5b21pUUN3ME2xOU43PDZ6IN88US=>	MofBV2FPT0WU
SF126	M17jPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mof6TWM2OD1zNT63Nlg2KM7:TR?=	NGLWUGZUSU6JRWK=
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CAL-85-1	M3H6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoexTWM2OD1{NT6xOVQ1KM7:TR?=	MlP4V2FPT0WU
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NCI-H1304	NY\zfG5KT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mkn6TWM2OD1\|Mz62NFM3KM7:TR?=	Mn\iV2FPT0WU
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RCC10RGB	NV;RRVdVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXLcZhFUUN3ME2zN{46PDN\|IN88US=>	NYX4eWJtW0GQR1XS
COLO-680N	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYjJR\|UxRTN2LkGzPVch\|ryP	NE\yfIJUSU6JRWK=
KURAMOCHI	NYfSe5VlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF;OSHdKSzVyPUO0MlY1OjVizszN	NXLOfottW0GQR1XS
NCI-H661	NIrFeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFXMOYZKSzVyPUO0Mlg1PDhizszN	M2L6WHNCVkeHUh?=
YAPC	MlfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkLqTWM2OD1\|NT65OVM{KM7:TR?=	NVqzPYxEW0GQR1XS
NCI-H526	MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTN5LkK3O\|Ih\|ryP	M1\HOHNCVkeHUh?=
A498	NVXNZ2N5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1vBS2lEPTB;M{iuNFk2PCEQvF2=	MmfVV2FPT0WU
VMRC-RCZ	NUjKc3F[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\6fY95UUN3ME2zPU4xODV2IN88US=>	MmnkV2FPT0WU
HCT-116	NHuwSHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXHJR\|UxRTN7LkC1PEDPxE1?	MXvTRW5ITVJ?
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OAW-42	Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2C0S2lEPTB;NECuNFU1OiEQvF2=	NXLHPVRDW0GQR1XS
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D-336MG	MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlLtTWM2OD12Mz6xNVUzKM7:TR?=	M{jJWHNCVkeHUh?=
SHP-77	M4\OeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTR\|LkG4Nlgh\|ryP	NUjHeZk5W0GQR1XS
SW872	Mn\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NInxZ4pKSzVyPUSzMlIyOjNizszN	NIDmRoZUSU6JRWK=
DBTRG-05MG	NFnSW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVLR[Jl3UUN3ME20OE43QTl4IN88US=>	MnnqV2FPT0WU
COLO-678	NFq5U4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MULJR\|UxRTR3LkewN\|Ih\|ryP	NYq1T2ZFW0GQR1XS
EGI-1	NXTFfWRyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVfJR\|UxRTR5LkG4N\|Mh\|ryP	Ml:4V2FPT0WU
KYSE-70	NFzBblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\HT2lEPTB;NEeuO\|IzOiEQvF2=	Mm[wV2FPT0WU
BALL-1	Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkfaTWM2OD12Nz64NlU1KM7:TR?=	NYTjVFdXW0GQR1XS
MDA-MB-361	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlnTTWM2OD12OD6wOFYh\|ryP	NXK4N\|hjW0GQR1XS
NCI-H1838	NEf2PXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{TpRWlEPTB;NEiuN\|Q2QCEQvF2=	NWnjVHZXW0GQR1XS
NCI-H1573	NXf3V2pbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\OdoFKSzVyPUS4MlY4QDVizszN	NXvnXmJWW0GQR1XS
HCC1395	Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV\JR\|UxRTR6Lkm5NkDPxE1?	NWXsPHk2W0GQR1XS
NCI-H2291	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmnOTWM2OD12OT61PVg5KM7:TR?=	MVHTRW5ITVJ?
RH-18	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmjBTWM2OD13MD6wPFg1KM7:TR?=	MWrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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LY2584702 ^New

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
LY2584702 Tosylate ^New

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
PF-4708671

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with K_i/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Rapamycin (Sirolimus)

Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.
MK-2206 2HCl

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

Features:The first allosteric small molecule inhibitor of Akt to enter clinical development.
CHIR-99021 (CT99021) HCl

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.
LY294002

LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family.
3-Methyladenine (3-MA)

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. Solutions of 3-MA are best fresh-prepared by heating.
Everolimus (RAD001)

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay.

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BI-D1870

Cited by 6 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

Choose Your Country or Region

By Signaling Pathways

By product type

BI-D1870

Cited by 6 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)