BI-D1870

Name: BI-D1870
Brand: Selleck Chemicals
SKU: S2843
Rating: 5 (25 reviews)

For research use only.

Catalog No.S2843

25 publications

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.

Selleck's BI-D1870 has been cited by 25 publications

EMBO Mol Med, 2020, 12(4):e11177

PubMed: 32115889 ( click the link to review the publication )

J Cell Sci, 2020, 10.1242/jcs.238295

PubMed: 32122945 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 521(2):492-498

PubMed: 31677783 ( click the link to review the publication )

Thyroid, 2020, 10.1089/thy.2019.0728

PubMed: 32762307 ( click the link to review the publication )

Cell Mol Life Sci, 2020, 10.1007/s00018-020-03617-5

PubMed: 32804243 ( click the link to review the publication )

Oncotarget, 2020, 11(25):2387-2403

PubMed: 32637030 ( click the link to review the publication )

Emerg Microbes Infect, 2020, 9(1):1748-1760

PubMed: 32691695 ( click the link to review the publication )

Nat Cell Biol, 2019, 21(6):778-790

PubMed: 31160710 ( click the link to review the publication )

Cell Rep, 2019, 26(12):3391-3399

PubMed: 30893610 ( click the link to review the publication )

Antiviral Res, 2019, 170:104572

PubMed: 31376425 ( click the link to review the publication )

J Biol Chem, 2019, 294(27):10530-10543

PubMed: 31126985 ( click the link to review the publication )

Cell Signal, 2019, 63:109362

PubMed: 31344438 ( click the link to review the publication )

Neurourol Urodyn, 2019, 38(6):1504-1516

PubMed: 31033016 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 37(1):135

PubMed: 29970115 ( click the link to review the publication )

Mol Biol Cell, 2018, 29(10):1258-1269

PubMed: 29540532 ( click the link to review the publication )

Nat Chem Biol, 2017, 13(12):1222-1231

PubMed: 28991240 ( click the link to review the publication )

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

Nat Commun, 2016, 7:11971

PubMed: 27321283 ( click the link to review the publication )

Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

J Immunol, 2015, 195(6):2529-39

PubMed: 26276876 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

PLoS Pathog, 2014, 10(6):e1004195

PubMed: 24945302 ( click the link to review the publication )
Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	NGLMXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF3qNpNKSzVyPUCuNFM2QCEQvF2=	NIXZRXhUSU6JRWK=
H9	NYT5RZp6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4Tjd2lEPTB;MD6wOlAyQSEQvF2=	MVLTRW5ITVJ?
KARPAS-45	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX3JR\|UxRTBwMU[1NlUh\|ryP	NWjaOG1xW0GQR1XS
NCI-H720	MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXrHR4dSUUN3ME2wMlE4OTl2IN88US=>	MXjTRW5ITVJ?
CTV-1	NUS4[opUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmPtTWM2OD1yLkS3PFczKM7:TR?=	NX24[Yh3W0GQR1XS
DU-4475	M4C0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2rBW2lEPTB;MD61NFQyPyEQvF2=	M4XJd3NCVkeHUh?=
A172	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV3VT\|NbUUN3ME2wMlUyPzB3IN88US=>	MmHxV2FPT0WU
EW-18	MnfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFvzSVFKSzVyPUCuOlIzOTFizszN	MUjTRW5ITVJ?
KU812	NWDjSHAyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGrFU3JKSzVyPUCuOlI3OjNizszN	Mm[yV2FPT0WU
KP-N-YS	NWThWXhZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlXDTWM2OD1yLk[4NlI{KM7:TR?=	NHnGbYFUSU6JRWK=
SBC-1	MmjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIfpRYNKSzVyPUCuOlk2OjRizszN	NFfUU5VUSU6JRWK=
ECC10	NEPvOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlnhTWM2OD1yLkewNFk1KM7:TR?=	MX\TRW5ITVJ?
GAMG	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXnJR\|UxRTBwN{S3NVch\|ryP	NYHKWphDW0GQR1XS
NCI-H209	M2fjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPicVJKSzVyPUCuO\|Y5OiEQvF2=	MkTSV2FPT0WU
MC-IXC	M1XmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYDJR\|UxRTBwN{m1PFkh\|ryP	MUjTRW5ITVJ?
HSC-3	M{fXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2q1SGlEPTB;MD64NVc3QSEQvF2=	MmLIV2FPT0WU
IST-SL1	M4fSVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2SyUmlEPTB;MD64OFU4PCEQvF2=	NImydmtUSU6JRWK=
LU-139	Ml65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHnRUWpKSzVyPUCuPFQ6PThizszN	M3Xv[nNCVkeHUh?=
ML-2	MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{LYOGlEPTB;MD64OVU4PSEQvF2=	NX;wSW1RW0GQR1XS
CAL-62	M2rFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXwTWM2OD1yLki4NVUzKM7:TR?=	M1fwWnNCVkeHUh?=
HL-60	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTBwOEizOlIh\|ryP	MmHuV2FPT0WU
KY821	M1jNSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXjtVm5rUUN3ME2wMlg5QDF{IN88US=>	M{O5UnNCVkeHUh?=
ES7	NYntVJBZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4DvTWlEPTB;MD65NVYxPyEQvF2=	NXz2VWI5W0GQR1XS
MV-4-11	M2fxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml;FTWM2OD1yLkm3PFk4KM7:TR?=	Mk\xV2FPT0WU
Daoy	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkHtTWM2OD1yLkm4O\|Y4KM7:TR?=	MkPrV2FPT0WU
EoL-1-cell	MnLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH32PGRKSzVyPUGuNFE5PzhizszN	Mkm0V2FPT0WU
TGW	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjoTWM2OD1zLkC1NVI1KM7:TR?=	NU\1N4dXW0GQR1XS
LAMA-84	NWLGVFlKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3HhW2lEPTB;MT6xNlc6PCEQvF2=	M{LIPHNCVkeHUh?=
KOSC-2	NFnwTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLGTWM2OD1zLkGzN\|g2KM7:TR?=	MmXCV2FPT0WU
A549	NEnPRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnOyTWM2OD1zLkOwPVU2KM7:TR?=	MkH3V2FPT0WU
CTB-1	M{mwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3LFcGlEPTB;MT60OFY4QSEQvF2=	MXHTRW5ITVJ?
NCI-H292	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XxdmlEPTB;MT60OlA3QSEQvF2=	NYGwN2V2W0GQR1XS
LoVo	M2C5Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHjSmZ{UUN3ME2xMlQ3PzV3IN88US=>	MonLV2FPT0WU
BFTC-905	MmjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWfJR\|UxRTFwNU[zN\|Ih\|ryP	M4DhOnNCVkeHUh?=
BE-13	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWPJR\|UxRTFwNUi3NFkh\|ryP	MlvVV2FPT0WU
KE-37	Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3jQOGlEPTB;MT61PVQ4QCEQvF2=	Mo[xV2FPT0WU
HN	M{DEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3HHW2lEPTB;MT62NVM3QCEQvF2=	NYfjO2xIW0GQR1XS
A3-KAW	M{PsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7oSVV5UUN3ME2xMlYzQDN2IN88US=>	NITPdVRUSU6JRWK=
NEC8	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fwbGlEPTB;MT63NFEyPSEQvF2=	NH61fG9USU6JRWK=
Ramos-2G6-4C10	NFfTZVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2r6dmlEPTB;MT63NFQ1PCEQvF2=	MWXTRW5ITVJ?
NB10	MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mni2TWM2OD1zLke3OlMh\|ryP	NETQbVhUSU6JRWK=
NBsusSR	NHX0cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYXJR\|UxRTFwOEK5OlEh\|ryP	NEP6TlBUSU6JRWK=
ES4	MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1zLSWlEPTB;MT64OVE1OyEQvF2=	MonpV2FPT0WU
ES8	NXXDdpVMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHHBdJhKSzVyPUGuPFc4OjRizszN	M1q1bHNCVkeHUh?=
CHL-1	M{nqXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFyzOVdKSzVyPUGuPVU4QTJizszN	NY\0T5kyW0GQR1XS
NCI-H2029	M2TXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4nZdGlEPTB;MT65O\|I1OSEQvF2=	NUTr[nBCW0GQR1XS
YKG-1	M4PTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLxflBrUUN3ME2xMlk5PDN{IN88US=>	MYrTRW5ITVJ?
BV-173	NHq1V3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYXucmpoUUN3ME2xMlk5PjZ4IN88US=>	NEXqSZZUSU6JRWK=
697	M{nqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGK4OohKSzVyPUKuNFIzOjhizszN	MVrTRW5ITVJ?
SK-NEP-1	MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVXJR\|UxRTJwMES0JO69VQ>?	M{\DTXNCVkeHUh?=
LOXIMVI	M1exd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHfWdItKSzVyPUKuNFQ1OzRizszN	M2XYOnNCVkeHUh?=
QIMR-WIL	NFvkV3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVrDVllkUUN3ME2yMlA4QDR7IN88US=>	MYfTRW5ITVJ?
DU-145	MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4LpdmlEPTB;Mj6xNVA2PiEQvF2=	Moi3V2FPT0WU
NB14	M17lW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYTHUFNPUUN3ME2yMlEyOzJzIN88US=>	NULsR45qW0GQR1XS
G-361	NEDzOlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MW\JR\|UxRTJwMUKyNUDPxE1?	Mn3XV2FPT0WU
BPH-1	NVvoTHhwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTJwMUK5OVch\|ryP	M1vSdHNCVkeHUh?=
KYSE-150	NIPDTGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFT3d2ZKSzVyPUKuNVUzOzRizszN	Mo\YV2FPT0WU
HMV-II	M3Hzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkD5TWM2OD1{LkG2OlM{KM7:TR?=	MUjTRW5ITVJ?
TE-9	NIX4bVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYDSS2ZtUUN3ME2yMlE4Ozd4IN88US=>	M13BO3NCVkeHUh?=
8-MG-BA	NIe3WFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\ucm1KSzVyPUKuNlM1PjFizszN	NXLhb4liW0GQR1XS
ES5	M4j6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUHw[XJ[UUN3ME2yMlI{PjN\|IN88US=>	M1G0cHNCVkeHUh?=
D-283MED	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nLbmlEPTB;Mj6yN\|Y6PSEQvF2=	NVHPOWI3W0GQR1XS
SK-N-AS	NXW0PWUxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVj6OHg2UUN3ME2yMlI6ODV7IN88US=>	Mn;CV2FPT0WU
SW1710	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml3MTWM2OD1{LkOwOlYyKM7:TR?=	NILlO\|hUSU6JRWK=
GCT	M1fHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGfEPGRKSzVyPUKuN\|E{PThizszN	NUjnbmR{W0GQR1XS
AGS	M{DR[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTJwM{S0NFQh\|ryP	M{HjfXNCVkeHUh?=
HuO9	NXnOUppzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDDT4xCUUN3ME2yMlM3QDJ2IN88US=>	NUno[mw3W0GQR1XS
MN-60	NFO3[GdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmDjTWM2OD1{LkS0PFg{KM7:TR?=	NYTYeYhqW0GQR1XS
NB6	NEDDVJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX3JR\|UxRTJwNEW3O\|kh\|ryP	NXW2dJN{W0GQR1XS
NCI-H1395	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTJwNEexNlEh\|ryP	M{PFTXNCVkeHUh?=
H4	M3izPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYfJR\|UxRTJwNEizPVMh\|ryP	MkfDV2FPT0WU
HT-3	M{TlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUXOdYV4UUN3ME2yMlUyODJ2IN88US=>	M1jle3NCVkeHUh?=
P12-ICHIKAWA	Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjDNGhKSzVyPUKuOVI2PTlizszN	Mnz3V2FPT0WU
COLO-800	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWrJR\|UxRTJwNUSxOlYh\|ryP	MX\TRW5ITVJ?
DB	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX\JR\|UxRTJwNUWwNVMh\|ryP	MXzTRW5ITVJ?
LCLC-97TM1	MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DGe2lEPTB;Mj62NFAzQCEQvF2=	M1jSenNCVkeHUh?=
Ca9-22	NEC1OmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3THeGlEPTB;Mj62OVk{OyEQvF2=	NIHqTGVUSU6JRWK=
Becker	NH3MfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnLjTWM2OD1{Lk[2NFc5KM7:TR?=	NFPudXFUSU6JRWK=
ACN	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTJwNk[3PUDPxE1?	NFexW3dUSU6JRWK=
SJSA-1	M1[yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MojtTWM2OD1{Lk[2PFch\|ryP	MmL5V2FPT0WU
NCI-H1048	NIT0b4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWSzOYU4UUN3ME2yMlY5OzJzIN88US=>	Mn;IV2FPT0WU
HEL	MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHSbIF5UUN3ME2yMlcxOjV2IN88US=>	MUPTRW5ITVJ?
NCI-H69	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTJwN{G2NFEh\|ryP	NIX1VlhUSU6JRWK=
639-V	NGP2cmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlywTWM2OD1{LkexO\|A{KM7:TR?=	NX\uXm9MW0GQR1XS
U251	MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoWxTWM2OD1{LkezNFMzKM7:TR?=	NUiyUGliW0GQR1XS
NCI-H1792	NFjTdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;YS5lMUUN3ME2yMlc{PzN6IN88US=>	NXf5bZRiW0GQR1XS
EW-1	MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFOw[XNKSzVyPUKuO\|U{OjhizszN	MXfTRW5ITVJ?
ME-180	M2H5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUjJR\|UxRTJwN{e3N\|Yh\|ryP	MXPTRW5ITVJ?
HH	Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2TVTGlEPTB;Mj64NFAxOSEQvF2=	MlHnV2FPT0WU
SW954	NXTUfZlMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTJwOEW4N{DPxE1?	MVLTRW5ITVJ?
SF268	M4TZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXzJR\|UxRTJwOEeyNlUh\|ryP	MXrTRW5ITVJ?
D-566MG	NWSwPZZTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXG2NodTUUN3ME2yMlkyOjl3IN88US=>	NHnyVGZUSU6JRWK=
EM-2	NVLIUVF{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV7JR\|UxRTJwOUKxPVMh\|ryP	MYXTRW5ITVJ?
NCI-H1299	NFjIVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGHOe2RKSzVyPUKuPVM4OzZizszN	NIe3fZJUSU6JRWK=
PSN1	NU\HV4VOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\GfHBKSzVyPUOuNFU4QDZizszN	NIfUWJRUSU6JRWK=
JVM-3	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHHVWm1KSzVyPUOuNFY4PTZizszN	NI\wSoRUSU6JRWK=
D-502MG	MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfCUpRJUUN3ME2zMlA4ODF7IN88US=>	MknsV2FPT0WU
SCC-4	NFuxZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV\QUXF1UUN3ME2zMlA6Ojd4IN88US=>	MlPPV2FPT0WU
GMS-10	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1\GeWlEPTB;Mz6wPVM5QCEQvF2=	NUHFXXlTW0GQR1XS
A427	MknzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTNwMUC4O\|Mh\|ryP	MmThV2FPT0WU
NH-12	MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkXTTWM2OD1\|LkGxOFU3KM7:TR?=	MmC3V2FPT0WU
KM12	M3z3bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M36wNmlEPTB;Mz6xNlI4OyEQvF2=	Mmn0V2FPT0WU
GI-1	Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFLUXHNKSzVyPUOuNVUzPTVizszN	MnfiV2FPT0WU
TE-8	NU[2b3lET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{W0[mlEPTB;Mz6xPVI{OSEQvF2=	NIfpT2lUSU6JRWK=
MKN1	NVvxfYpKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlLzTWM2OD1\|LkKwPFc2KM7:TR?=	MmPsV2FPT0WU
NCI-H810	NXzqR2d1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHr3WG9KSzVyPUOuNlIyPTVizszN	MYjTRW5ITVJ?
GOTO	M4PFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{nzTmlEPTB;Mz6yPFAxPCEQvF2=	M1PtfnNCVkeHUh?=
T98G	MoHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUjKT4dKUUN3ME2zMlI5OjF4IN88US=>	Ml3SV2FPT0WU
HD-MY-Z	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHPsNnNKSzVyPUOuN\|Y2PDJizszN	MnnFV2FPT0WU
SNU-C2B	M4Da[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHm4cXJKSzVyPUOuN\|kxQTdizszN	Mlr2V2FPT0WU
MOLT-4	NX\PO4lHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXPWlFFUUN3ME2zMlM6ODl6IN88US=>	M1vPWnNCVkeHUh?=
RPMI-7951	NVXFe\|lpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\ZOWlEPTB;Mz6zPVc{KM7:TR?=	MlTrV2FPT0WU
EW-11	NGf0ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGfXSFNKSzVyPUOuOFEzOjRizszN	NVLRWlcxW0GQR1XS
RD	NEnwRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTNwNEOxN\|Ih\|ryP	MmfIV2FPT0WU
SW48	M{GzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4XTOGlEPTB;Mz60N\|M2QCEQvF2=	MlK1V2FPT0WU
BB65-RCC	NVmz[JVLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{P4VGlEPTB;Mz60OVM6PiEQvF2=	MUXTRW5ITVJ?
Ca-Ski	NX:ycmlGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXvJR\|UxRTNwNEe1NVQh\|ryP	MWPTRW5ITVJ?
CHP-134	M4nRNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTK[JVKSzVyPUOuOFg4PThizszN	NIe5elJUSU6JRWK=
CAL-33	NFjvZZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoXNTWM2OD1\|LkWzN\|YzKM7:TR?=	NFfkPHdUSU6JRWK=
TYK-nu	M1XKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVzsPVJtUUN3ME2zMlU{Pjd4IN88US=>	MWDTRW5ITVJ?
LB831-BLC	NIPSRZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NG\lPVhKSzVyPUOuOVQxOTZizszN	M4HCVnNCVkeHUh?=
KU-19-19	M3HMOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHezZpJKSzVyPUOuOlA{ODRizszN	NV3Fd4hVW0GQR1XS
KG-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NE\yV2FKSzVyPUOuOlEyODZizszN	NUPJcJp[W0GQR1XS
COLO-829	Mmi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUX3PXgyUUN3ME2zMlY3PjF6IN88US=>	MWXTRW5ITVJ?
HUTU-80	NH64bnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXzJR\|UxRTNwNk[2NlEh\|ryP	MWTTRW5ITVJ?
NCI-H446	M3PQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX3JR\|UxRTNwNkizOEDPxE1?	MUHTRW5ITVJ?
LB2241-RCC	MnTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRTNwNki2NlUh\|ryP	NGXTR3hUSU6JRWK=
JEG-3	NXvVWmh3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYDJR\|UxRTNwNkmxPUDPxE1?	NELaU\|hUSU6JRWK=
LNCaP-Clone-FGC	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWrvS2l1UUN3ME2zMlcxODRzIN88US=>	NEfoWmlUSU6JRWK=
M059J	M1LDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFnFOGxKSzVyPUOuO\|E1PjhizszN	MX3TRW5ITVJ?
SK-MES-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3fUNGlEPTB;Mz63N\|A{KM7:TR?=	MXTTRW5ITVJ?
GT3TKB	Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFfENXZKSzVyPUOuO\|U3ODRizszN	M1O3U3NCVkeHUh?=
DOK	NFrUUXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTNwN{[1NlYh\|ryP	MnzjV2FPT0WU
HO-1-N-1	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2faZWlEPTB;Mz63PVgxOSEQvF2=	NH;kcWRUSU6JRWK=
MZ1-PC	NIDLXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVXRRYxTUUN3ME2zMlgzQDh\|IN88US=>	M3nlWnNCVkeHUh?=
8305C	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVrFcItFUUN3ME2zMlg5QTR\|IN88US=>	NH;uZYxUSU6JRWK=
CGTH-W-1	M{OyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYfJR\|UxRTNwOUO1NFQh\|ryP	MVrTRW5ITVJ?
LU-134-A	NIm0OGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlL6TWM2OD1\|Lkm1OFIzKM7:TR?=	NGfZTXpUSU6JRWK=
C32	M3nHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV;JR\|UxRTNwOU[1PFEh\|ryP	NXq5OW5KW0GQR1XS
MOLT-13	NYX1WoY2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NY\JV4w1UUN3ME2zMlk3QDV4IN88US=>	MX;TRW5ITVJ?
A375	M3vzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NES5OXZKSzVyPUSuNFUyPjJizszN	NI\DdoJUSU6JRWK=
CAL-12T	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVTFRol7UUN3ME20MlA2Pzl3IN88US=>	NE\mRmJUSU6JRWK=
IGR-1	NH3B[4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTRwMUCyO\|Qh\|ryP	NU\HdnRQW0GQR1XS
LB1047-RCC	M2j2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTRwMUC0OFEh\|ryP	NHjubVRUSU6JRWK=
BHT-101	MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHjBVXlKSzVyPUSuNVA3QDNizszN	M3;B[HNCVkeHUh?=
A431	MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTPTWM2OD12LkG0NFgyKM7:TR?=	NYHib5U2W0GQR1XS
EPLC-272H	NYW4UmRiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXNVmF7UUN3ME20MlE4PTl4IN88US=>	MkW1V2FPT0WU
HT-1376	NF3CcJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVewc2liUUN3ME20MlI{ODV7IN88US=>	NYHpbG5FW0GQR1XS
HCC1954	M{nBO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVrIPI8zUUN3ME20MlI2PzR4IN88US=>	NE[1SI5USU6JRWK=
KYSE-510	M4\abWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIr0b45KSzVyPUSuNlYxQSEQvF2=	NULib5hpW0GQR1XS
PANC-03-27	NV7GZWZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVfPNmFuUUN3ME20MlMxODh\|IN88US=>	NVWzSlFSW0GQR1XS
MDA-MB-157	NULY[2JZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmX3TWM2OD12LkOwOlU3KM7:TR?=	MnnyV2FPT0WU
HOP-62	NXW1fYp2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXfJR\|UxRTRwM{C4OVYh\|ryP	MYHTRW5ITVJ?
ETK-1	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTRwM{[yNFMh\|ryP	NX\KU2JJW0GQR1XS
MIA-PaCa-2	NVTPdZZuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mo\aTWM2OD12LkO2NlI4KM7:TR?=	NVH6NJFXW0GQR1XS
MHH-PREB-1	NHTi[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYHJR\|UxRTRwM{m3O\|Mh\|ryP	NXPCN\|NXW0GQR1XS
LXF-289	NYrDUIdvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3TJXGlEPTB;ND60NFIxOiEQvF2=	MojVV2FPT0WU
ATN-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2Dqc2lEPTB;ND60NlM1OSEQvF2=	MULTRW5ITVJ?
8505C	NWrWZ4htT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2LDdWlEPTB;ND60OVgzPSEQvF2=	NXLaOZNwW0GQR1XS
HOS	NHXVeFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFz0RpBKSzVyPUSuOFY1PTNizszN	NEfj[2RUSU6JRWK=
U-266	NFHrPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGj6bJJKSzVyPUSuOlExOzJizszN	M3W4SnNCVkeHUh?=
5637	NF7HVm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIjCRVFKSzVyPUSuOlE1PDRizszN	MXXTRW5ITVJ?
GCIY	M4S1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWTIN2tqUUN3ME20MlcyODF3IN88US=>	M4rDZnNCVkeHUh?=
MDA-MB-231	NGLmZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmX6TWM2OD12LkeyNVE2KM7:TR?=	MXLTRW5ITVJ?
RKO	M4PJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2r3dWlEPTB;ND63NlgyPyEQvF2=	NUPaPINzW0GQR1XS
COR-L23	NU[3[GFMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3;IWWlEPTB;ND63OFI2PiEQvF2=	NG\3VJlUSU6JRWK=
DJM-1	MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NELaR4pKSzVyPUSuO\|k4OjlizszN	NYfPcGQ1W0GQR1XS
D-423MG	NVPNVFZzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrHWItKSzVyPUSuPFA5ODNizszN	Mk\OV2FPT0WU
DMS-114	MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmfLTWM2OD12LkixN\|g3KM7:TR?=	NFv1WG9USU6JRWK=
MHH-ES-1	NUXMdJhWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MknRTWM2OD12LkiyOVA1KM7:TR?=	M3\3OHNCVkeHUh?=
CAL-51	M1nJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPlfIZKSzVyPUSuPFY5PDNizszN	NFPEV4VUSU6JRWK=
SW626	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIWzU2NKSzVyPUSuPFk3QTdizszN	M2K3V3NCVkeHUh?=
COLO-824	M321XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFLtNW5KSzVyPUSuPVA1ODhizszN	NGnNfIhUSU6JRWK=
NCI-H1437	NUjaUppCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3LQXWlEPTB;ND65Nlk{KM7:TR?=	M3T3NHNCVkeHUh?=
CAL-39	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfQOYVFUUN3ME20Mlk{QTh6IN88US=>	MYXTRW5ITVJ?
PC-3	NHTTSJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV[2[JNlUUN3ME20Mlk1PjR6IN88US=>	MmfOV2FPT0WU
A101D	MoXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn;WTWM2OD12Lkm2PFY2KM7:TR?=	NEnyfJJUSU6JRWK=
ES1	NWjCcm1JT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDRWmtOUUN3ME21MlAxOTNizszN	NXLjdIV4W0GQR1XS
TE-1	NFfRWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{nEUGlEPTB;NT6wN\|Y3PiEQvF2=	NWHWZ2lEW0GQR1XS
KP-N-YN	M1zxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjEbY5KSzVyPUWuNFU3PyEQvF2=	MXHTRW5ITVJ?
EFO-27	Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV\UZ3NtUUN3ME21MlA3OzJ7IN88US=>	MVPTRW5ITVJ?
BT-549	NEHvXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3zvWGlEPTB;NT6wO\|c{PiEQvF2=	Mkn3V2FPT0WU
HLE	MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWDNOWg1UUN3ME21MlEyPzN2IN88US=>	MnLnV2FPT0WU
SW982	M{PQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVqzXW9EUUN3ME21MlE{Ozd2IN88US=>	NIDubm5USU6JRWK=
SCC-25	NXrlb3dFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7NVolsUUN3ME21MlE6ODR4IN88US=>	NYfP[Fh{W0GQR1XS
SK-MEL-28	MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnO4TWM2OD13LkKwN\|E{KM7:TR?=	NH3lNIdUSU6JRWK=
CaR-1	NYrFNJRDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGWxNpJKSzVyPUWuNlA4OjZizszN	NIXhUoxUSU6JRWK=
MLMA	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XWcWlEPTB;NT6yN\|Q{PiEQvF2=	M1y0dXNCVkeHUh?=
VM-CUB-1	MoftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3u2b2lEPTB;NT6yN\|Q{QSEQvF2=	MULTRW5ITVJ?
KNS-42	M4L0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHjSfGpKSzVyPUWuNlYyPiEQvF2=	MV3TRW5ITVJ?
TK10	M4LvXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlTwTWM2OD13LkO2NFg3KM7:TR?=	Ml3zV2FPT0WU
MEG-01	NFTvflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoCyTWM2OD13LkO2Nlc1KM7:TR?=	M4jNNXNCVkeHUh?=
DEL	NF3iUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MW\JR\|UxRTVwM{mwNlMh\|ryP	MlO2V2FPT0WU
SJRH30	MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHBOIFjUUN3ME21MlM6OjF\|IN88US=>	NEX2eJVUSU6JRWK=
SK-PN-DW	NVq3OHNGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTENpRTUUN3ME21MlQ{PTh7IN88US=>	Mn3OV2FPT0WU
TE-10	M3XaR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fzVWlEPTB;NT60OFg6OyEQvF2=	NYSzUFhvW0GQR1XS
KNS-81-FD	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTVwNUCwPVIh\|ryP	MomyV2FPT0WU
BHY	NVr3NI9vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml20TWM2OD13LkWxNFch\|ryP	NV\5WFI{W0GQR1XS
KYSE-270	NHH6[HBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEnJOohKSzVyPUWuOVM2OzZizszN	NFHFR5JUSU6JRWK=
NCI-H650	M3\1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoLzTWM2OD13LkW3NVE1KM7:TR?=	MlOwV2FPT0WU
L-363	M4m1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1i0NmlEPTB;NT62PVQ4PiEQvF2=	MnuzV2FPT0WU
TCCSUP	NUDPbm92T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXTMeo5JUUN3ME21MlcyPzd6IN88US=>	M4L3[nNCVkeHUh?=
SCH	NWTjUoVIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4TLUGlEPTB;NT63OFc3PyEQvF2=	NXzDRo5OW0GQR1XS
HTC-C3	MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmHVTWM2OD13Lke3OlQ1KM7:TR?=	MYLTRW5ITVJ?
J-RT3-T3-5	NYPXfo52T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVzkUFdGUUN3ME21MlgxPzl2IN88US=>	MY\TRW5ITVJ?
Hs-578-T	M332d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVHEV3VUUUN3ME21Mlg{PjB5IN88US=>	MnS1V2FPT0WU
M14	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{OzV2lEPTB;NT64OlczPiEQvF2=	MX\TRW5ITVJ?
HT-144	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX;JR\|UxRTVwOE[4N\|Ih\|ryP	MkjlV2FPT0WU
CAL-54	NX[5d3l2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFT5doNKSzVyPUWuPVM{OTRizszN	MknCV2FPT0WU
T47D	Mkm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnK0TWM2OD13Lkm2NVIh\|ryP	MoniV2FPT0WU
GB-1	Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml3oTWM2OD14LkCyNFY5KM7:TR?=	NGXHOlhUSU6JRWK=
HSC-2	NWO4SHN1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1\wZWlEPTB;Nj6xNlM2OyEQvF2=	MUHTRW5ITVJ?
SiHa	NGjJfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HwZ2lEPTB;Nj6xOFA6PyEQvF2=	NGrTb2JUSU6JRWK=
OMC-1	M2nIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4n0UWlEPTB;Nj6zOVQ1OSEQvF2=	NUKzV\|hpW0GQR1XS
HGC-27	MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mm[3TWM2OD14LkO1O\|g3KM7:TR?=	M3TWSHNCVkeHUh?=
FTC-133	NUm0PYx7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnWyTWM2OD14LkS2OVUyKM7:TR?=	MmHjV2FPT0WU
KS-1	NUXrN3hNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnX3TWM2OD14LkWyNVQ4KM7:TR?=	MoH5V2FPT0WU
HT-1080	MlP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2HnO2lEPTB;Nj61OFA1OiEQvF2=	NHzlTo5USU6JRWK=
SKG-IIIa	MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTZwNU[yOlMh\|ryP	NXLmN3NpW0GQR1XS
OCUB-M	MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXvzeYhYUUN3ME22MlYxPzdizszN	M2j0V3NCVkeHUh?=
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Detroit562	NUfS[2oxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXjc2Z1UUN3ME22Mlg2QTlzIN88US=>	NFe5VmZUSU6JRWK=
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IGROV-1	MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUjJR\|UxRTZwOUK1PFMh\|ryP	MVjTRW5ITVJ?
OVCAR-8	NHGzW2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTZwOUSyNlkh\|ryP	MUTTRW5ITVJ?
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KYSE-520	Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTdwMkmyPUDPxE1?	MULTRW5ITVJ?
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OVCAR-4	NHnaXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1zlbWlEPTB;Nz61OVI3KM7:TR?=	NGDmfppUSU6JRWK=
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NCI-H2087	Mk\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1jpSmlEPTB;OD6zOlE2QCEQvF2=	M{faOnNCVkeHUh?=
NCI-H2122	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRThwNEC0O\|kh\|ryP	MYfTRW5ITVJ?
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NCI-H23	MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVTJR\|UxRTF{LkOxNlUh\|ryP	NGP5U5FUSU6JRWK=
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Calu-3	NVrLVoFnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlTGTWM2OD1zND64O\|Q{KM7:TR?=	MoWxV2FPT0WU
CW-2	NYr5eG1PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkL5TWM2OD1zNT6wNlI{KM7:TR?=	MUnTRW5ITVJ?
COLO-679	NF;uWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mlm0TWM2OD1zNT6xNFE{KM7:TR?=	MlywV2FPT0WU
NCI-SNU-5	M2Pwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTyTWM2OD1zNT61OVg6KM7:TR?=	NHm1UYlUSU6JRWK=
AN3-CA	NIDL[41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MljXTWM2OD1zNT62OFY5KM7:TR?=	NX\wb\|I6W0GQR1XS
SF126	NEOz[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTF3LkeyPFUh\|ryP	NUG5V412W0GQR1XS
D-247MG	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{[4dWlEPTB;MUWuPFU{OyEQvF2=	NUHneGRiW0GQR1XS
UACC-62	NI\NXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWDJR\|UxRTF3Lkm2OkDPxE1?	MUPTRW5ITVJ?
GP5d	NIjYXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFHiWFZKSzVyPUG2MlEyPzFizszN	NYfZR4tuW0GQR1XS
HuO-3N1	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWPXNHNqUUN3ME2xOk4zPDd\|IN88US=>	NHXvc2JUSU6JRWK=
NCI-H1092	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYjCXlRrUUN3ME2xOk43Ojl5IN88US=>	MW\TRW5ITVJ?
HCC1187	MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTpTWM2OD1zNj62OVU4KM7:TR?=	MojtV2FPT0WU
G-402	M4\2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fLdWlEPTB;MU[uPFU3PSEQvF2=	NWjFdmJKW0GQR1XS
HT55	NVm0Ulk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlTsTWM2OD1zNj64O\|UyKM7:TR?=	M3nLV3NCVkeHUh?=
NCI-H2009	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M124dmlEPTB;MU[uPVI3PiEQvF2=	MVHTRW5ITVJ?
SH-4	NHfV[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHP3RlRKSzVyPUG2Mlk6OiEQvF2=	NYexdYpWW0GQR1XS
SW1783	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2jiT2lEPTB;MU[uPVk6QCEQvF2=	M1jv[HNCVkeHUh?=
HT	NYTjfoZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1PXTGlEPTB;MUeuNVk3PCEQvF2=	MU\TRW5ITVJ?
CP66-MEL	MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MljMTWM2OD1zNz6zNFEh\|ryP	M4jzSnNCVkeHUh?=
BEN	M4LPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NE\oWpVKSzVyPUG3MlU3OjZizszN	MX;TRW5ITVJ?
HCC38	Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVfJR\|UxRTF5Lke2PVgh\|ryP	MYHTRW5ITVJ?
LAN-6	Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkXpTWM2OD1zNz64OFg2KM7:TR?=	NH7TfXZUSU6JRWK=
RERF-LC-MS	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVvQdHBFUUN3ME2xO{46OTJ7IN88US=>	NWHLcFl4W0GQR1XS
NCI-H1770	MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml3qTWM2OD1zNz65OFkyKM7:TR?=	MYPTRW5ITVJ?
LCLC-103H	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX;JR\|UxRTF6LkC1NUDPxE1?	MYDTRW5ITVJ?
NCI-H520	NYrFTo9VT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnjnTWM2OD1zOD6zNlgyKM7:TR?=	MUTTRW5ITVJ?
LU-65	NHOzNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV3JR\|UxRTF6LkSwOFMh\|ryP	M376cXNCVkeHUh?=
SK-MEL-3	M3nQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXfJR\|UxRTF6Lk[2O\|kh\|ryP	NFntcoNUSU6JRWK=
LK-2	M{PaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2DHZmlEPTB;MUiuO\|czOyEQvF2=	MWnTRW5ITVJ?
PANC-08-13	NFvEbGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXzHSFVJUUN3ME2xPE44QDh7IN88US=>	NV;2SmZmW0GQR1XS
NCI-H460	NU\aWXJYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHjwXXpKSzVyPUG4Mlg1PjZizszN	Mn3PV2FPT0WU
COLO-684	M3\6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NU\Qb5BJUUN3ME2xPE46QTV4IN88US=>	NHOyfWJUSU6JRWK=
RPMI-2650	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfvd4txUUN3ME2xPU4xOTJizszN	MlPIV2FPT0WU
NY	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVLJR\|UxRTF7LkG1Olch\|ryP	MUDTRW5ITVJ?
NB7	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYX0dVROUUN3ME2xPU4yPzV\|IN88US=>	MW\TRW5ITVJ?
NCI-H358	NEPi[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mor0TWM2OD1zOT6yOlc{KM7:TR?=	M2L1enNCVkeHUh?=
MC116	NUTxdmZkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NILkbnlKSzVyPUG5MlU{OzFizszN	NUHNd44xW0GQR1XS
MS-1	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVfJR\|UxRTF7Lk[xNFMh\|ryP	NFPQOHdUSU6JRWK=
NCI-H82	NWTqcYExT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4e3XWlEPTB;MUmuOlg4QCEQvF2=	NEeyd4hUSU6JRWK=
OCI-AML2	NXLZRpJxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUfJR\|UxRTF7LkewN\|Ih\|ryP	M4WwNHNCVkeHUh?=
LS-123	NH6z[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mmf2TWM2OD1{MD6wNVk1KM7:TR?=	MlX2V2FPT0WU
PC-14	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XvZmlEPTB;MkCuNVg{PCEQvF2=	NX;2[Yk6W0GQR1XS
NCI-H1703	M4H6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFT5WpdKSzVyPUKwMlgyPzNizszN	MXrTRW5ITVJ?
Calu-6	MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYrPc4lVUUN3ME2yNU4yODB3IN88US=>	M{DobHNCVkeHUh?=
no-11	M3rSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlvNTWM2OD1{MT6xOlAzKM7:TR?=	MnHMV2FPT0WU
NCI-H727	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnGxTWM2OD1{MT6zOFk{KM7:TR?=	MYHTRW5ITVJ?
DSH1	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUfKXXNEUUN3ME2yNU4{QDd7IN88US=>	MW\TRW5ITVJ?
KYSE-140	Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHrTR2dKSzVyPUKxMlczPzFizszN	MV3TRW5ITVJ?
RH-1	NFfnVHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEDuTGVKSzVyPUKxMlg5OyEQvF2=	NIX3d5JUSU6JRWK=
HAL-01	NHm2S2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3jBfWlEPTB;MkKuNFQyQCEQvF2=	NELWdnpUSU6JRWK=
RXF393	NIH3SItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4nSemlEPTB;MkKuNlc5QSEQvF2=	NF7OephUSU6JRWK=
LS-411N	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYDhT41UUUN3ME2yNk4zQDZ7IN88US=>	NUHud3BKW0GQR1XS
no-10	Mn3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2\LcWlEPTB;MkKuOVAxPCEQvF2=	M1T6[HNCVkeHUh?=
MKN7	NEi4O\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnD[5VKUUN3ME2yNk43QDdizszN	NWOzSGpIW0GQR1XS
AU565	M2HNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{HJVmlEPTB;MkKuO\|Q4QCEQvF2=	MVzTRW5ITVJ?
NUGC-3	M2f5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlS0TWM2OD1{Mz6xNVk6KM7:TR?=	MVrTRW5ITVJ?
EW-16	NW[5fldTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MojkTWM2OD1{ND6wPVI3KM7:TR?=	MV3TRW5ITVJ?
HCC70	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHLzTFJKSzVyPUK0MlE{OjNizszN	NE\jUnhUSU6JRWK=
RPMI-8226	NELqdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\BWZNEUUN3ME2yOE4{OTV3IN88US=>	NUnBOIRwW0GQR1XS
CFPAC-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHn5[pVKSzVyPUK0MlYzPzJizszN	NXXtfmhLW0GQR1XS
DoTc2-4510	NWX5RnVbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUGxenVPUUN3ME2yOE44PTd3IN88US=>	MW\TRW5ITVJ?
KNS-62	MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYT3UYxwUUN3ME2yOU4xOThizszN	NHqzcJNUSU6JRWK=
SK-N-DZ	MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1PFSGlEPTB;MkWuNFkxPCEQvF2=	MXPTRW5ITVJ?
CAL-85-1	M4\NT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXi0UIJzUUN3ME2yOU4yPTR2IN88US=>	NUDKXnZ{W0GQR1XS
JVM-2	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWnJR\|UxRTJ3LkKxNlIh\|ryP	NYXBPGt3W0GQR1XS
NCI-H2347	NFz3UmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVLJR\|UxRTJ3LkSyOFkh\|ryP	NFjaZnBUSU6JRWK=
P30-OHK	NV:xO3p4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVLJR\|UxRTJ3Lk[zNVgh\|ryP	NFrqS\|ZUSU6JRWK=
SK-N-FI	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{naTmlEPTB;Mk[uNVE3OiEQvF2=	NUDVSVJnW0GQR1XS
CAMA-1	NF6xXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXPJR\|UxRTJ4LkS4O\|Yh\|ryP	NXPvTWNxW0GQR1XS
MHH-NB-11	NWHGOoc6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXXEbIp2UUN3ME2yOk42QDVzIN88US=>	M33DXnNCVkeHUh?=
IST-MEL1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGjkdIhKSzVyPUK2MlcyPzdizszN	NUP0dlRHW0GQR1XS
KARPAS-299	NVvLTIszT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV\JR\|UxRTJ5LkS3NFEh\|ryP	M1L6ZnNCVkeHUh?=
TE-11	MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3\2TmlEPTB;MkeuO\|M1OiEQvF2=	Ml;XV2FPT0WU
769-P	NEXidIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX;JR\|UxRTJ6LkS1N\|Mh\|ryP	NWrkUHNJW0GQR1XS
CAL-72	MmDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1zobmlEPTB;MkiuOVU3OSEQvF2=	MlvzV2FPT0WU
NCI-H2342	MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXT1cVBSUUN3ME2yPU4{QDB\|IN88US=>	NHrTRlJUSU6JRWK=
NCI-H1651	NVW5dGhGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn34TWM2OD1{OT64OVA{KM7:TR?=	Ml;3V2FPT0WU
OE33	NYn4cWhlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTNyLkGzOFIh\|ryP	MkjVV2FPT0WU
HuP-T4	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfTWG5NUUN3ME2zNU41QDN5IN88US=>	MY\TRW5ITVJ?
U-118-MG	NIKxbnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4r1VGlEPTB;M{KuOVQ1OSEQvF2=	MWjTRW5ITVJ?
SN12C	M4nsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1e2d2lEPTB;M{KuPFgyPSEQvF2=	MYXTRW5ITVJ?
TE-5	M4q1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NUiyOJZUUUN3ME2zN{4yOzZ6IN88US=>	NUjNNFJRW0GQR1XS
KM-H2	NH;0SmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2nYTmlEPTB;M{OuNVY6QSEQvF2=	MnHVV2FPT0WU
OVCAR-3	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3XSfGlEPTB;M{OuOFEzPyEQvF2=	NUizXW5PW0GQR1XS
NCI-H1304	M4G2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{nHVmlEPTB;M{OuOlA{PiEQvF2=	NVLwemFVW0GQR1XS
LU-135	M2XD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{DnT2lEPTB;M{OuO\|A5PiEQvF2=	MVTTRW5ITVJ?
S-117	NWrJRldHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUnJR\|UxRTN\|LkeyPFYh\|ryP	M1S1fnNCVkeHUh?=
NCI-H1755	NUmxfmpET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkXJTWM2OD1\|Mz64NVEh\|ryP	MlHOV2FPT0WU
Mo-T	NGPETZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojFTWM2OD1\|Mz64OVk{KM7:TR?=	NHjMc49USU6JRWK=
SK-OV-3	NWW4e2Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYTJR\|UxRTN\|Lki4OVQh\|ryP	MmnrV2FPT0WU
RCC10RGB	M1v4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWLxd2VLUUN3ME2zN{46PDN\|IN88US=>	NILyN4hUSU6JRWK=
COLO-680N	M4nvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWHJR\|UxRTN2LkGzPVch\|ryP	NW\JU5huW0GQR1XS
KURAMOCHI	NEPZXJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HhbmlEPTB;M{SuOlQzPSEQvF2=	M{DnPXNCVkeHUh?=
NCI-H661	Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2DIcWlEPTB;M{SuPFQ1QCEQvF2=	MoLiV2FPT0WU
YAPC	NIH4eY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUPKVXNsUUN3ME2zOU46PTN\|IN88US=>	NUnKW5JlW0GQR1XS
NCI-H526	M2P4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHHHN5dKSzVyPUO3MlI4PzJizszN	NGrRb25USU6JRWK=
A498	M{T5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkPJTWM2OD1\|OD6wPVU1KM7:TR?=	MVLTRW5ITVJ?
VMRC-RCZ	NETpVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTN7LkCwOVQh\|ryP	NUC1UGtPW0GQR1XS
HCT-116	NI\kS\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1PGNmlEPTB;M{muNFU5KM7:TR?=	MVnTRW5ITVJ?
COLO-320-HSR	NGXYcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHHaeppKSzVyPUSwMlA1OSEQvF2=	NVX2XYNZW0GQR1XS
OAW-42	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3LlbWlEPTB;NECuNFU1OiEQvF2=	NGizR4FUSU6JRWK=
SK-MEL-1	Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYrJR\|UxRTRyLkK5Nlch\|ryP	NGfuOG5USU6JRWK=
IST-MES1	M1PlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXzz[3NTUUN3ME20NE44PjV\|IN88US=>	MXLTRW5ITVJ?
CP50-MEL-B	Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4XTVWlEPTB;NEGuNFc6PyEQvF2=	M1nXfnNCVkeHUh?=
RMG-I	NEjscVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MULJR\|UxRTR{LkS5NlEh\|ryP	M4X0WnNCVkeHUh?=
D-336MG	M2C2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{DKe2lEPTB;NEOuNVE2OiEQvF2=	M{jkOnNCVkeHUh?=
SHP-77	NGLYdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MofzTWM2OD12Mz6xPFI5KM7:TR?=	NUHnW4gyW0GQR1XS
SW872	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnnyTWM2OD12Mz6yNVI{KM7:TR?=	NYHuNGljW0GQR1XS
DBTRG-05MG	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTR2Lk[5PVYh\|ryP	MYPTRW5ITVJ?
COLO-678	M1y2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTR3LkewN\|Ih\|ryP	MlPIV2FPT0WU
EGI-1	M4\5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4rZNmlEPTB;NEeuNVg{OyEQvF2=	M1TwO3NCVkeHUh?=
KYSE-70	NI\vO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWTTcIExUUN3ME20O{44OjJ{IN88US=>	M3;6VnNCVkeHUh?=
BALL-1	MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1\sT2lEPTB;NEeuPFI2PCEQvF2=	MYTTRW5ITVJ?
MDA-MB-361	NYjOSWxQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml3NTWM2OD12OD6wOFYh\|ryP	NWLvcWNuW0GQR1XS
NCI-H1838	Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlzDTWM2OD12OD6zOFU5KM7:TR?=	NXHvSllrW0GQR1XS
NCI-H1573	NHXhe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXnYOIlWUUN3ME20PE43Pzh3IN88US=>	MULTRW5ITVJ?
HCC1395	MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUXTSW9JUUN3ME20PE46QTJizszN	MV7TRW5ITVJ?
NCI-H2291	M2O0eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPyeYNKSzVyPUS5MlU6QDhizszN	NVLRSGNQW0GQR1XS
RH-18	NYrESJNrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYG2TIdIUUN3ME21NE4xQDh2IN88US=>	M1[0OnNCVkeHUh?=

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Assay

Methods	Test Index	PMID
Western blot	p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis. p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.	17040210 28415756 25395420
Immunofluorescence	PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei. PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.	25002506
Growth inhibition assay	Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls. Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.	28415756

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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The Serial Dilution Calculator Equation

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C2=C1/X	C2:	LOG(C2):
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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

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