BI-D1870

Name: BI-D1870
Brand: Selleck Chemicals
SKU: S2843
Rating: 5 (15 reviews)

For research use only. Not for use in humans.

Catalog No.S2843

15 publications

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Selleck's BI-D1870 has been cited by 15 publications

Nat Cell Biol, 2019, 21(6):778-790

PubMed: 31160710 ( click the link to review the publication )

Cell Rep, 2019, 26(12):3391-3399

PubMed: 30893610 ( click the link to review the publication )

Antiviral Res, 2019, 170:104572

PubMed: 31376425 ( click the link to review the publication )

J Biol Chem, 2019, 294(27):10530-10543

PubMed: 31126985 ( click the link to review the publication )

Neurourol Urodyn, 2019, 38(6):1504-1516

PubMed: 31033016 ( click the link to review the publication )

J Exp Clin Cancer Res, 2018, 37(1):135

PubMed: 29970115 ( click the link to review the publication )

Mol Biol Cell, 2018, 29(10):1258-1269

PubMed: 29540532 ( click the link to review the publication )

Nat Chem Biol, 2017, 13(12):1222-1231

PubMed: 28991240 ( click the link to review the publication )

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

Nat Commun, 2016, 7:11971

PubMed: 27321283 ( click the link to review the publication )

Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

4 Customer Reviews

Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.
(g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.
HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.
Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	NGDrfllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NE[4W\|FKSzVyPUCuNFM2QCEQvF2=	MmW4V2FPT0WU
H9	MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoriTWM2OD1yLkC2NFE6KM7:TR?=	NXSybYt3W0GQR1XS
KARPAS-45	Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{HCc2lEPTB;MD6xOlUzPSEQvF2=	MoCyV2FPT0WU
NCI-H720	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTBwMUexPVQh\|ryP	M3uwcHNCVkeHUh?=
CTV-1	M{TCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{j4eGlEPTB;MD60O\|g4OiEQvF2=	NIfxRolUSU6JRWK=
DU-4475	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTBwNUC0NVch\|ryP	MUnTRW5ITVJ?
A172	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2fQXWlEPTB;MD61NVcxPSEQvF2=	M2PIWXNCVkeHUh?=
EW-18	MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHIUGFzUUN3ME2wMlYzOjFzIN88US=>	NX3FT5NsW0GQR1XS
KU812	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGrIfpVKSzVyPUCuOlI3OjNizszN	NWO1U4FxW0GQR1XS
KP-N-YS	MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWXJR\|UxRTBwNkiyNlMh\|ryP	M1X4dHNCVkeHUh?=
SBC-1	NYLsVWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{S4e2lEPTB;MD62PVUzPCEQvF2=	NEj0d5NUSU6JRWK=
ECC10	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFGyT4lKSzVyPUCuO\|AxQTRizszN	MkfZV2FPT0WU
GAMG	NF[5d\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnG0TWM2OD1yLke0O\|E4KM7:TR?=	M1vyc3NCVkeHUh?=
NCI-H209	NGm5SIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGDhfZpKSzVyPUCuO\|Y5OiEQvF2=	MnrMV2FPT0WU
MC-IXC	MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWHJTVVCUUN3ME2wMlc6PTh7IN88US=>	NFz2XlJUSU6JRWK=
HSC-3	NIjTeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoTnTWM2OD1yLkixO\|Y6KM7:TR?=	NHjQbYtUSU6JRWK=
IST-SL1	MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEL2Z5lKSzVyPUCuPFQ2PzRizszN	NIDVNo5USU6JRWK=
LU-139	M{LQeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTBwOES5OVgh\|ryP	M3HQN3NCVkeHUh?=
ML-2	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH;zToNKSzVyPUCuPFU2PzVizszN	MnWzV2FPT0WU
CAL-62	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVLhdHljUUN3ME2wMlg5OTV{IN88US=>	M1TqPXNCVkeHUh?=
HL-60	NHjF[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\3RmlEPTB;MD64PFM3OiEQvF2=	Mn;WV2FPT0WU
KY821	NFzFenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYrJR\|UxRTBwOEi4NVIh\|ryP	NInacnVUSU6JRWK=
ES7	NWr6O\|RWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYWzWW9CUUN3ME2wMlkyPjB5IN88US=>	MYrTRW5ITVJ?
MV-4-11	M2HQdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVzJR\|UxRTBwOUe4PVch\|ryP	NVTGcFlJW0GQR1XS
Daoy	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nadmlEPTB;MD65PFc3PyEQvF2=	M4LLW3NCVkeHUh?=
EoL-1-cell	NIWwZ3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX\4SHM2UUN3ME2xMlAyQDd6IN88US=>	NIDlcIRUSU6JRWK=
TGW	NELIfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4fNUWlEPTB;MT6wOVEzPCEQvF2=	MlnYV2FPT0WU
LAMA-84	M4HNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MnXaTWM2OD1zLkGyO\|k1KM7:TR?=	NYHDfJl[W0GQR1XS
KOSC-2	M4C4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGHDc45KSzVyPUGuNVM{QDVizszN	M4PBVnNCVkeHUh?=
A549	NVK4UYZbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDCdnVHUUN3ME2xMlMxQTV3IN88US=>	NXrn[FRNW0GQR1XS
CTB-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;GTWM2OD1zLkS0Olc6KM7:TR?=	MXLTRW5ITVJ?
NCI-H292	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MU\JR\|UxRTFwNE[wOlkh\|ryP	M{OwdHNCVkeHUh?=
LoVo	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1iwW2lEPTB;MT60Olc2PSEQvF2=	M3jqR3NCVkeHUh?=
BFTC-905	NWTCVGRVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXPVdY1UUUN3ME2xMlU3OzN{IN88US=>	NH\VcGJUSU6JRWK=
BE-13	MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYDJR\|UxRTFwNUi3NFkh\|ryP	MlPzV2FPT0WU
KE-37	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXXJR\|UxRTFwNUm0O\|gh\|ryP	NFLJOYhUSU6JRWK=
HN	Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGLHOlBKSzVyPUGuOlE{PjhizszN	M13rS3NCVkeHUh?=
A3-KAW	NF;qPZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnTCTWM2OD1zLk[yPFM1KM7:TR?=	NFXpeZBUSU6JRWK=
NEC8	M1jjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTFwN{CxNVUh\|ryP	M1r2dXNCVkeHUh?=
Ramos-2G6-4C10	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXq4bHByUUN3ME2xMlcxPDR2IN88US=>	MYPTRW5ITVJ?
NB10	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXu4ZopqUUN3ME2xMlc4PjNizszN	NYL4XHNlW0GQR1XS
NBsusSR	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULP[3NHUUN3ME2xMlgzQTZzIN88US=>	MYjTRW5ITVJ?
ES4	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3:we2lEPTB;MT64OVE1OyEQvF2=	MknYV2FPT0WU
ES8	NFrPS41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIDTWmhKSzVyPUGuPFc4OjRizszN	MoTDV2FPT0WU
CHL-1	MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTFwOUW3PVIh\|ryP	M2PLW3NCVkeHUh?=
NCI-H2029	NYPVOIM5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIC3dJFKSzVyPUGuPVczPDFizszN	M3jWbXNCVkeHUh?=
YKG-1	NVHoNZEzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTFwOUi0N\|Ih\|ryP	NWnVb5FtW0GQR1XS
BV-173	NVHXbpRRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWnJR\|UxRTFwOUi2OlYh\|ryP	NHvTO2xUSU6JRWK=
697	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVnJR\|UxRTJwMEKyNlgh\|ryP	NUTnfWtVW0GQR1XS
SK-NEP-1	M{nufmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofpTWM2OD1{LkC0OEDPxE1?	MkX1V2FPT0WU
LOXIMVI	NFHSb5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnfKTWM2OD1{LkC0OFM1KM7:TR?=	Mn7FV2FPT0WU
QIMR-WIL	NY\Xe\|NNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MY\JR\|UxRTJwMEe4OFkh\|ryP	M1jXVHNCVkeHUh?=
DU-145	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGXQeXRKSzVyPUKuNVExPTZizszN	NXmyT3BDW0GQR1XS
NB14	M4\wb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYP4SFdGUUN3ME2yMlEyOzJzIN88US=>	NG\BfoxUSU6JRWK=
G-361	M3\qZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWG0dFBPUUN3ME2yMlEzOjFizszN	M3nqVHNCVkeHUh?=
BPH-1	NHHTOpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHHZPHVKSzVyPUKuNVI6PTdizszN	M1K2VXNCVkeHUh?=
KYSE-150	NW\kSmlET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTJwMUWyN\|Qh\|ryP	MUTTRW5ITVJ?
HMV-II	NEjD[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1;DV2lEPTB;Mj6xOlY{OyEQvF2=	M4nSZ3NCVkeHUh?=
TE-9	MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnzaTWM2OD1{LkG3N\|c3KM7:TR?=	M1XYbHNCVkeHUh?=
8-MG-BA	NX3rTXRjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYnvWW5lUUN3ME2yMlI{PDZzIN88US=>	MXrTRW5ITVJ?
ES5	NGi0PYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF[wc4tKSzVyPUKuNlM3OzNizszN	MmX0V2FPT0WU
D-283MED	M4PQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXq4O5R[UUN3ME2yMlI{Pjl3IN88US=>	NUHrXWhYW0GQR1XS
SK-N-AS	NHPKc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MlT2TWM2OD1{LkK5NFU6KM7:TR?=	NUO2VGdnW0GQR1XS
SW1710	NHHye3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVjmSnJjUUN3ME2yMlMxPjZzIN88US=>	M1fabHNCVkeHUh?=
GCT	NH23bpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoOxTWM2OD1{LkOxN\|U5KM7:TR?=	NFzMNphUSU6JRWK=
AGS	NXvxO5hYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnX1TWM2OD1{LkO0OFA1KM7:TR?=	MorXV2FPT0WU
HuO9	NI\qZYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M33pWWlEPTB;Mj6zOlgzPCEQvF2=	NEjYRlZUSU6JRWK=
MN-60	M4HEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVvJR\|UxRTJwNES4PFMh\|ryP	MX7TRW5ITVJ?
NB6	NH;TO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoqyTWM2OD1{LkS1O\|c6KM7:TR?=	M2XlTHNCVkeHUh?=
NCI-H1395	M1yyU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH65bFNKSzVyPUKuOFcyOjFizszN	NYryXot[W0GQR1XS
H4	M13RbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fiPGlEPTB;Mj60PFM6OyEQvF2=	MXfTRW5ITVJ?
HT-3	M3Lxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M17Qc2lEPTB;Mj61NVAzPCEQvF2=	NHPPd21USU6JRWK=
P12-ICHIKAWA	NGnSeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWDyT4tIUUN3ME2yMlUzPTV7IN88US=>	M3HHW3NCVkeHUh?=
COLO-800	MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Ml\UTWM2OD1{LkW0NVY3KM7:TR?=	M3zrT3NCVkeHUh?=
DB	NIDZcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\CTWM2OD1{LkW1NFE{KM7:TR?=	NHmyfZhUSU6JRWK=
LCLC-97TM1	NGD3cJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXfJR\|UxRTJwNkCwNlgh\|ryP	MUnTRW5ITVJ?
Ca9-22	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXrJR\|UxRTJwNkW5N\|Mh\|ryP	MVLTRW5ITVJ?
Becker	Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH3K[4NKSzVyPUKuOlYxPzhizszN	M2rYVHNCVkeHUh?=
ACN	NYDETmFwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MoL3TWM2OD1{Lk[2O\|kh\|ryP	MYDTRW5ITVJ?
SJSA-1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mk[1TWM2OD1{Lk[2PFch\|ryP	MXXTRW5ITVJ?
NCI-H1048	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGDwNYtKSzVyPUKuOlg{OjFizszN	MXfTRW5ITVJ?
HEL	NU\SNI9lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Moj6TWM2OD1{LkewNlU1KM7:TR?=	MmXsV2FPT0WU
NCI-H69	M3TjUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYnJR\|UxRTJwN{G2NFEh\|ryP	MnHDV2FPT0WU
639-V	NUn3S2pNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmHjTWM2OD1{LkexO\|A{KM7:TR?=	Mle5V2FPT0WU
U251	NX7VdW1GT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnzZTWM2OD1{LkezNFMzKM7:TR?=	NESxV4JUSU6JRWK=
NCI-H1792	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYrzd\|ZvUUN3ME2yMlc{PzN6IN88US=>	M{LhXnNCVkeHUh?=
EW-1	NVXyToR{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3q2[GlEPTB;Mj63OVMzQCEQvF2=	M2fhPXNCVkeHUh?=
ME-180	NV;abnhUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYnJR\|UxRTJwN{e3N\|Yh\|ryP	NUmzRlhOW0GQR1XS
HH	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXfXbZNMUUN3ME2yMlgxODBzIN88US=>	M{Dxb3NCVkeHUh?=
SW954	NG\RZ3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2jGcGlEPTB;Mj64OVg{KM7:TR?=	MVTTRW5ITVJ?
SF268	NE\tW2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHLyUYtKSzVyPUKuPFczOjVizszN	MWrTRW5ITVJ?
D-566MG	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{jl[GlEPTB;Mj65NVI6PSEQvF2=	NHy4XmtUSU6JRWK=
EM-2	M3LzcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYPqOW06UUN3ME2yMlkzOTl\|IN88US=>	M1\xcnNCVkeHUh?=
NCI-H1299	MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmLOTWM2OD1{LkmzO\|M3KM7:TR?=	NYDC[lRZW0GQR1XS
PSN1	NGTrO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUiydXBXUUN3ME2zMlA2Pzh4IN88US=>	NFzXOolUSU6JRWK=
JVM-3	NW\XfG04T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1HMZ2lEPTB;Mz6wOlc2PiEQvF2=	MVvTRW5ITVJ?
D-502MG	M1jQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYDj[4hPUUN3ME2zMlA4ODF7IN88US=>	MUDTRW5ITVJ?
SCC-4	NXPWd3ptT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVXvS\|N7UUN3ME2zMlA6Ojd4IN88US=>	MV\TRW5ITVJ?
GMS-10	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVrJR\|UxRTNwMEmzPFgh\|ryP	MlvRV2FPT0WU
A427	M4PyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWrJR\|UxRTNwMUC4O\|Mh\|ryP	NV\JTXRjW0GQR1XS
NH-12	MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTNwMUG0OVYh\|ryP	NV7hfmo6W0GQR1XS
KM12	MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrkTWM2OD1\|LkGyNlc{KM7:TR?=	NFn5co5USU6JRWK=
GI-1	M{PGW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NETZemxKSzVyPUOuNVUzPTVizszN	M13CWXNCVkeHUh?=
TE-8	M{XsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWWxVWgzUUN3ME2zMlE6OjNzIN88US=>	M3;oTnNCVkeHUh?=
MKN1	NYHt[3l[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF:ybXFKSzVyPUOuNlA5PzVizszN	MWDTRW5ITVJ?
NCI-H810	NEXleoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4DSOGlEPTB;Mz6yNlE2PSEQvF2=	NVXZe4NFW0GQR1XS
GOTO	NX3NV2RmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlW3TWM2OD1\|LkK4NFA1KM7:TR?=	MUjTRW5ITVJ?
T98G	M3u0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXfJZphtUUN3ME2zMlI5OjF4IN88US=>	NHXNXGdUSU6JRWK=
HD-MY-Z	NULxV5Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmD6TWM2OD1\|LkO2OVQzKM7:TR?=	MXzTRW5ITVJ?
SNU-C2B	NXv0V3BXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPVTWM2OD1\|LkO5NFk4KM7:TR?=	MlL2V2FPT0WU
MOLT-4	NIjYSZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1XnPGlEPTB;Mz6zPVA6QCEQvF2=	MlfHV2FPT0WU
RPMI-7951	Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUm3fYFpUUN3ME2zMlM6PzNizszN	M3zvbnNCVkeHUh?=
EW-11	NXm1S5BvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHLHUopKSzVyPUOuOFEzOjRizszN	NWPJZWxwW0GQR1XS
RD	NU\hfm9zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVrJR\|UxRTNwNEOxN\|Ih\|ryP	MmLDV2FPT0WU
SW48	M2Dabmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1\4VmlEPTB;Mz60N\|M2QCEQvF2=	NWXFZm45W0GQR1XS
BB65-RCC	MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUHocm9LUUN3ME2zMlQ2Ozl4IN88US=>	MlzzV2FPT0WU
Ca-Ski	NIC0colIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2r1bmlEPTB;Mz60O\|UyPCEQvF2=	NIXZdYZUSU6JRWK=
CHP-134	NXnLNnZMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUPJR\|UxRTNwNEi3OVgh\|ryP	MWnTRW5ITVJ?
CAL-33	M4nUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYfJR\|UxRTNwNUOzOlIh\|ryP	M4DHRXNCVkeHUh?=
TYK-nu	NYKxNmtmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF7hS\|FKSzVyPUOuOVM3PzZizszN	NID1UI9USU6JRWK=
LB831-BLC	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlP1TWM2OD1\|LkW0NFE3KM7:TR?=	NHLNd5lUSU6JRWK=
KU-19-19	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{WwdGlEPTB;Mz62NFMxPCEQvF2=	MlPnV2FPT0WU
KG-1	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3HwW2lEPTB;Mz62NVExPiEQvF2=	M1y0RXNCVkeHUh?=
COLO-829	NX;GcXJzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2DkbGlEPTB;Mz62OlYyQCEQvF2=	NHnyV5ZUSU6JRWK=
HUTU-80	M4SxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWHJR\|UxRTNwNk[2NlEh\|ryP	NVTwOnlqW0GQR1XS
NCI-H446	MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYjJR\|UxRTNwNkizOEDPxE1?	NHjGVpFUSU6JRWK=
LB2241-RCC	M3Xp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmL6TWM2OD1\|Lk[4OlI2KM7:TR?=	NYfuWpRnW0GQR1XS
JEG-3	NVz4OGRHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1vhWmlEPTB;Mz62PVE6KM7:TR?=	NV3WOoxHW0GQR1XS
LNCaP-Clone-FGC	M3\4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXXJR\|UxRTNwN{CwOFEh\|ryP	NYDWUHdXW0GQR1XS
M059J	MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mom2TWM2OD1\|LkexOFY5KM7:TR?=	NXzHZYRCW0GQR1XS
SK-MES-1	Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkjwTWM2OD1\|LkezNFMh\|ryP	NWPxd\|A3W0GQR1XS
GT3TKB	NGrqcIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1zRZmlEPTB;Mz63OVYxPCEQvF2=	NW\iOZZCW0GQR1XS
DOK	NVXXWGRET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYXJR\|UxRTNwN{[1NlYh\|ryP	MX3TRW5ITVJ?
HO-1-N-1	NVPz[HI{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGXV[41KSzVyPUOuO\|k5ODFizszN	NI\5VpFUSU6JRWK=
MZ1-PC	M3S1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVnJR\|UxRTNwOEK4PFMh\|ryP	MYLTRW5ITVJ?
8305C	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2P2U2lEPTB;Mz64PFk1OyEQvF2=	MXPTRW5ITVJ?
CGTH-W-1	MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTNwOUO1NFQh\|ryP	MVjTRW5ITVJ?
LU-134-A	NFzZOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX3pbFQ1UUN3ME2zMlk2PDJ{IN88US=>	Mln6V2FPT0WU
C32	NF\yPVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYPMcJgzUUN3ME2zMlk3PThzIN88US=>	M4rkeHNCVkeHUh?=
MOLT-13	NUX2XYl4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV7JR\|UxRTNwOU[4OVYh\|ryP	M1P5WXNCVkeHUh?=
A375	Ml\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXfJR\|UxRTRwMEWxOlIh\|ryP	NHfmN4tUSU6JRWK=
CAL-12T	NUPsc21sT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4H0dGlEPTB;ND6wOVc6PSEQvF2=	NXvXO205W0GQR1XS
IGR-1	NUPoVJE{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnTlTWM2OD12LkGwNlc1KM7:TR?=	NWm2eFd2W0GQR1XS
LB1047-RCC	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NV;xWpJZUUN3ME20MlExPDRzIN88US=>	M2TXVnNCVkeHUh?=
BHT-101	M1;5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGfEe2NKSzVyPUSuNVA3QDNizszN	MX\TRW5ITVJ?
A431	MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEn1WI1KSzVyPUSuNVQxQDFizszN	M4TLVXNCVkeHUh?=
EPLC-272H	NHvVOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV3YdpFRUUN3ME20MlE4PTl4IN88US=>	NInUd5hUSU6JRWK=
HT-1376	NWnQNJFlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1niT2lEPTB;ND6yN\|A2QSEQvF2=	NV;4cHhWW0GQR1XS
HCC1954	NH;JWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX3JR\|UxRTRwMkW3OFYh\|ryP	NEC5PIFUSU6JRWK=
KYSE-510	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEfWXYFKSzVyPUSuNlYxQSEQvF2=	NHfKdGhUSU6JRWK=
PANC-03-27	M2rjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofWTWM2OD12LkOwNFg{KM7:TR?=	NFPOZYtUSU6JRWK=
MDA-MB-157	NHm1cmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LqPWlEPTB;ND6zNFY2PiEQvF2=	NYXSdVhxW0GQR1XS
HOP-62	NEnHUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYfONWgyUUN3ME20MlMxQDV4IN88US=>	MmnxV2FPT0WU
ETK-1	NXvEOo4xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1rtU2lEPTB;ND6zOlIxOyEQvF2=	NVXLfIdqW0GQR1XS
MIA-PaCa-2	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;wTWM2OD12LkO2NlI4KM7:TR?=	NXr1[WNSW0GQR1XS
MHH-PREB-1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVnJR\|UxRTRwM{m3O\|Mh\|ryP	MlXDV2FPT0WU
LXF-289	NYSzOlJCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH3MU3NKSzVyPUSuOFAzODJizszN	NXG2XIk{W0GQR1XS
ATN-1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4SxemlEPTB;ND60NlM1OSEQvF2=	M2XUNnNCVkeHUh?=
8505C	NHq0b5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHHBV3lKSzVyPUSuOFU5OjVizszN	NWTEdXF{W0GQR1XS
HOS	MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlfsTWM2OD12LkS2OFU{KM7:TR?=	MnHRV2FPT0WU
U-266	NWD0fnc4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGS4[5pKSzVyPUSuOlExOzJizszN	MknxV2FPT0WU
5637	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXnYSFlzUUN3ME20MlYyPDR2IN88US=>	MWnTRW5ITVJ?
GCIY	MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXLFXVR2UUN3ME20MlcyODF3IN88US=>	MYDTRW5ITVJ?
MDA-MB-231	MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTRwN{KxNVUh\|ryP	NU\tNmhxW0GQR1XS
RKO	NUHFZoNUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUDFPIpFUUN3ME20MlczQDF5IN88US=>	NFj5RndUSU6JRWK=
COR-L23	M{DIOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYrORYkzUUN3ME20Mlc1OjV4IN88US=>	MUnTRW5ITVJ?
DJM-1	NIfvcHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MonOTWM2OD12Lke5O\|I6KM7:TR?=	MlzYV2FPT0WU
D-423MG	MnT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTRwOEC4NFMh\|ryP	NFPwfXRUSU6JRWK=
DMS-114	NGD1b2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\u[WlEPTB;ND64NVM5PiEQvF2=	M17DVnNCVkeHUh?=
MHH-ES-1	NFTydFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkX6TWM2OD12LkiyOVA1KM7:TR?=	MWTTRW5ITVJ?
CAL-51	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUTpeoVOUUN3ME20Mlg3QDR\|IN88US=>	NGjIXmNUSU6JRWK=
SW626	NEHXSI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUHJR\|UxRTRwOEm2PVch\|ryP	MVXTRW5ITVJ?
COLO-824	NXXSWHE1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDmTJJUUUN3ME20MlkxPDB6IN88US=>	Ml;XV2FPT0WU
NCI-H1437	MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUXBPG9bUUN3ME20MlkzQTNizszN	NEjZWXJUSU6JRWK=
CAL-39	NInQSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFHYWZJKSzVyPUSuPVM6QDhizszN	NFvDb4VUSU6JRWK=
PC-3	Mn;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3zrR2lEPTB;ND65OFY1QCEQvF2=	NFq1dpRUSU6JRWK=
A101D	M1LESmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2PzZmlEPTB;ND65Olg3PSEQvF2=	NHPFTFRUSU6JRWK=
ES1	NYf6eJhwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;nTWM2OD13LkCwNVMh\|ryP	M2K5PHNCVkeHUh?=
TE-1	M2jFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MU\JR\|UxRTVwMEO2OlYh\|ryP	NHXKXohUSU6JRWK=
KP-N-YN	Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFm1TI1KSzVyPUWuNFU3PyEQvF2=	MmLGV2FPT0WU
EFO-27	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH64O3hKSzVyPUWuNFY{OjlizszN	MmXmV2FPT0WU
BT-549	M4TTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NE\hZpVKSzVyPUWuNFc4OzZizszN	NWPWZYpiW0GQR1XS
HLE	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NI\nOYZKSzVyPUWuNVE4OzRizszN	MlXlV2FPT0WU
SW982	NI\ifY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV\lb\|A3UUN3ME21MlE{Ozd2IN88US=>	Mlv1V2FPT0WU
SCC-25	NG\u[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGmwO\|ZKSzVyPUWuNVkxPDZizszN	MmfLV2FPT0WU
SK-MEL-28	NUK3PYQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXHJR\|UxRTVwMkCzNVMh\|ryP	MoTlV2FPT0WU
CaR-1	M{ThbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVjJR\|UxRTVwMkC3NlYh\|ryP	Ml;vV2FPT0WU
MLMA	NYfO[VRlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{W0PGlEPTB;NT6yN\|Q{PiEQvF2=	MmTyV2FPT0WU
VM-CUB-1	NVf6XpBkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XDfGlEPTB;NT6yN\|Q{QSEQvF2=	NHG5SIlUSU6JRWK=
KNS-42	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWTNPYtDUUN3ME21MlI3OTZizszN	NWrIc3ZnW0GQR1XS
TK10	MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4LifGlEPTB;NT6zOlA5PiEQvF2=	Mo\WV2FPT0WU
MEG-01	NX2wNmw2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGnUUFNKSzVyPUWuN\|YzPzRizszN	MmHhV2FPT0WU
DEL	NU\pZmttT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWO5WYExUUN3ME21MlM6ODJ\|IN88US=>	MV\TRW5ITVJ?
SJRH30	NIDieXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmDiTWM2OD13LkO5NlE{KM7:TR?=	NV35NHBJW0GQR1XS
SK-PN-DW	NXmyRXRvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M13COWlEPTB;NT60N\|U5QSEQvF2=	Ml23V2FPT0WU
TE-10	NEfZcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{W4UWlEPTB;NT60OFg6OyEQvF2=	NVHzOXR7W0GQR1XS
KNS-81-FD	NU\tcYloT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2fNZWlEPTB;NT61NFA6OiEQvF2=	NVHkRWJ[W0GQR1XS
BHY	NGLTcppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVrJR\|UxRTVwNUGwO{DPxE1?	M2D5THNCVkeHUh?=
KYSE-270	NVvpNZBiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVvJR\|UxRTVwNUO1N\|Yh\|ryP	MVTTRW5ITVJ?
NCI-H650	MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXGxeVc3UUN3ME21MlU4OTF2IN88US=>	NFK3[HFUSU6JRWK=
L-363	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4naVmlEPTB;NT62PVQ4PiEQvF2=	MkXNV2FPT0WU
TCCSUP	M4HSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1zxOmlEPTB;NT63NVc4QCEQvF2=	NX73eGY1W0GQR1XS
SCH	M4XqV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXHJR\|UxRTVwN{S3Olch\|ryP	MmTYV2FPT0WU
HTC-C3	M{PMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXfjT3dOUUN3ME21Mlc4PjR2IN88US=>	M3G2U3NCVkeHUh?=
J-RT3-T3-5	NUHjS2xlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml3RTWM2OD13LkiwO\|k1KM7:TR?=	MoHkV2FPT0WU
Hs-578-T	MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MljsTWM2OD13LkizOlA4KM7:TR?=	MnWyV2FPT0WU
M14	MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUTJR\|UxRTVwOE[3NlYh\|ryP	NFfQN4lUSU6JRWK=
HT-144	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVq2WVMzUUN3ME21Mlg3QDN{IN88US=>	NEfq[\|FUSU6JRWK=
CAL-54	Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXzBcXRzUUN3ME21Mlk{OzF2IN88US=>	MmHyV2FPT0WU
T47D	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{XXZmlEPTB;NT65OlEzKM7:TR?=	MmHUV2FPT0WU
GB-1	MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWPJR\|UxRTZwMEKwOlgh\|ryP	M4CycnNCVkeHUh?=
HSC-2	M3fUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmK0TWM2OD14LkGyN\|U{KM7:TR?=	NIO4c5VUSU6JRWK=
SiHa	NWLLPI85T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jVTWlEPTB;Nj6xOFA6PyEQvF2=	M{fIc3NCVkeHUh?=
OMC-1	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnjrTWM2OD14LkO1OFQyKM7:TR?=	M3XOVnNCVkeHUh?=
HGC-27	MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{m2eWlEPTB;Nj6zOVc5PiEQvF2=	MnG5V2FPT0WU
FTC-133	NGTvenNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIXWVnRKSzVyPU[uOFY2PTFizszN	NHvGT3hUSU6JRWK=
KS-1	MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MW\JR\|UxRTZwNUKxOFch\|ryP	MWfTRW5ITVJ?
HT-1080	MnvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXnudGtKUUN3ME22MlU1ODR{IN88US=>	MlT2V2FPT0WU
SKG-IIIa	NULCdG5yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWPJR\|UxRTZwNU[yOlMh\|ryP	MmHvV2FPT0WU
OCUB-M	MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NED4b4RKSzVyPU[uOlA4PyEQvF2=	NF7HbmhUSU6JRWK=
MDA-MB-175-VII	M{jaVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{PM[WlEPTB;Nj62NlA6KM7:TR?=	MoniV2FPT0WU
BB30-HNC	NVn2WZpWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmfwTWM2OD14Lk[3OFQ1KM7:TR?=	NVSySXNtW0GQR1XS
D-542MG	NHnpV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH63dHlKSzVyPU[uO\|MxQSEQvF2=	Mki0V2FPT0WU
NCI-H2405	MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIqzU\|NKSzVyPU[uO\|Q5PTVizszN	NV\CVII2W0GQR1XS
SW1573	NGDSbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV\JR\|UxRTZwN{izNVkh\|ryP	M3O2SnNCVkeHUh?=
NCI-SNU-1	NWLCN3R7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXLJR\|UxRTZwN{mwNlIh\|ryP	NG\4O\|FUSU6JRWK=
RT-112	NF7yNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTZwN{m0OlMh\|ryP	NFHCSFFUSU6JRWK=
COR-L88	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NF\VPVVKSzVyPU[uO\|k4QTFizszN	NGHkPFZUSU6JRWK=
SCC-9	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4PacWlEPTB;Nj64NlU2KM7:TR?=	MlvjV2FPT0WU
U-87-MG	MlfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NX3XdW9yUUN3ME22Mlg{QDJ4IN88US=>	MmW4V2FPT0WU
Detroit562	NFHUWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2nYcWlEPTB;Nj64OVk6OSEQvF2=	NHfXUI1USU6JRWK=
LC-2-ad	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnLaTWM2OD14Lki2NlkzKM7:TR?=	NEnyTG1USU6JRWK=
IGROV-1	NHLWe4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEixeotKSzVyPU[uPVI2QDNizszN	MV;TRW5ITVJ?
OVCAR-8	NX\PVW1LT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofHTWM2OD14Lkm0NlI6KM7:TR?=	NUn5RYpYW0GQR1XS
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NOS-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4fnNmlEPTB;Nz6yNFQyPSEQvF2=	NXyyd2t{W0GQR1XS
HEC-1	Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTdwMkWzPFch\|ryP	NGjncIlUSU6JRWK=
GI-ME-N	NUnDdVBwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvFT4pOUUN3ME23MlI6OTV6IN88US=>	MmjCV2FPT0WU
KYSE-520	NFu1UopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mni0TWM2OD15LkK5Nlkh\|ryP	MnL5V2FPT0WU
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C-33-A	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUSzdXAyUUN3ME23MlQ4QDJizszN	NIPK[ZJUSU6JRWK=
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OVCAR-4	M1XYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLkTJhKSzVyPUeuOVUzPiEQvF2=	NYTDR4p[W0GQR1XS
KYSE-450	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUXJR\|UxRTdwNkO3PVEh\|ryP	MVrTRW5ITVJ?
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OVCAR-5	Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVfOV4RKUUN3ME23MlgzOzJ7IN88US=>	MnLKV2FPT0WU
K5	NYHiPZN6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M371fGlEPTB;Nz64O\|QzKM7:TR?=	NEXHbZpUSU6JRWK=
786-0	M{\YfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXzOcpdHUUN3ME24MlA{ODl3IN88US=>	NXGwe5FCW0GQR1XS
NCI-H747	MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2qwPGlEPTB;OD6wOFQ2PyEQvF2=	MWfTRW5ITVJ?
CAL-27	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NES3dGxKSzVyPUiuNVI4OiEQvF2=	NHj1eYVUSU6JRWK=
FADU	NYTxbIZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlrFTWM2OD16LkG3OVQ{KM7:TR?=	M1fRV3NCVkeHUh?=
SW780	M2fqO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn;DTWM2OD16LkG4PFIyKM7:TR?=	NVzhU40yW0GQR1XS
ACHN	NGDaUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXjJR\|UxRThwMkK1Nlkh\|ryP	MWnTRW5ITVJ?
TE-6	Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVHJR\|UxRThwMkO3PFgh\|ryP	NUnue3BZW0GQR1XS
NCI-H2087	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYTaTG1HUUN3ME24MlM3OTV6IN88US=>	MVrTRW5ITVJ?
NCI-H2122	MlXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\ITWM2OD16LkSwOFc6KM7:TR?=	MoX6V2FPT0WU
SK-LU-1	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGOw[XZKSzVyPUiuOFM6QTdizszN	Mn[zV2FPT0WU
22RV1	NH\TbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFH2NJJKSzVyPUiuOlE4QDZizszN	NHjkU\|dUSU6JRWK=
MEL-JUSO	NIfVZ25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGDrWGdKSzVyPUiuOlg3PzVizszN	MUjTRW5ITVJ?
UM-UC-3	MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVHHdpUxUUN3ME24MlcyOzlizszN	NEj5c\|RUSU6JRWK=
HuH-7	NEnQSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkHDTWM2OD16LkezNFEzKM7:TR?=	M{WzVXNCVkeHUh?=
SNU-449	MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRThwN{WyOlUh\|ryP	MlfTV2FPT0WU
RVH-421	NXTQeZF4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrm[ZA5UUN3ME24Mlc2Ozl6IN88US=>	MUfTRW5ITVJ?
MFM-223	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTJNXNKSzVyPUiuPFA4OzVizszN	MWXTRW5ITVJ?
CHP-212	MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NY\JW3A1UUN3ME24MlgzOjZ5IN88US=>	NHXFNXFUSU6JRWK=
NCI-H28	NVP1VXQyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfoSmQ4UUN3ME24Mlg2OTh3IN88US=>	MmHHV2FPT0WU
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DMS-273	Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MV;JR\|UxRThwOEm2NlMh\|ryP	MX\TRW5ITVJ?
MPP-89	M1P2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWH5N3JMUUN3ME24MlkyOzRzIN88US=>	MnXqV2FPT0WU
EW-22	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYLhU4k4UUN3ME24MlkyOzh{IN88US=>	NITBS4xUSU6JRWK=
RCM-1	NHTqWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1jwXGlEPTB;OD65OlQ5PiEQvF2=	M3OxW3NCVkeHUh?=
BT-474	NFn5fFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn;sTWM2OD16Lkm4PFczKM7:TR?=	NFnuTI5USU6JRWK=
TI-73	M17vemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MV\JR\|UxRTlwMEO0PVYh\|ryP	NGPabo9USU6JRWK=
ES3	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1H6b2lEPTB;OT6wOVE2PiEQvF2=	MV\TRW5ITVJ?
NB17	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFfm[m5KSzVyPUmuNVQ2OzVizszN	NGnJSItUSU6JRWK=
MOLT-16	MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUf1eJQ2UUN3ME25MlE3PjV3IN88US=>	NX7qRZNvW0GQR1XS
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NB12	NXy2NnNpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYrJR\|UxRTlwM{SwPFEh\|ryP	M4HWXHNCVkeHUh?=
MEL-HO	NU[2PZdyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVO4TnRCUUN3ME25MlQxOiEQvF2=	MXvTRW5ITVJ?
HuCCT1	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2raTmlEPTB;OT60O\|QxPiEQvF2=	MUPTRW5ITVJ?
A704	NXL2VlFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVXJR\|UxRTlwNEe3OFUh\|ryP	NIXwOWlUSU6JRWK=
SW756	Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWjJR\|UxRTlwNUWzOlEh\|ryP	Ml7QV2FPT0WU
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KINGS-1	M4K5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFPmZ5FKSzVyPUmuOlk{PyEQvF2=	NXzHdIV[W0GQR1XS
NKM-1	Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHOxU4pKSzVyPUmuPFM6PjRizszN	MoT1V2FPT0WU
C2BBe1	MmXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlfUTWM2OD17Lki2NlA1KM7:TR?=	M17qNnNCVkeHUh?=
A204	NULoVpFzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnzVTWM2OD17Lki5O\|U2KM7:TR?=	Mkf6V2FPT0WU
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PFSK-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYPJR\|UxRTlwOUW2Olkh\|ryP	M3z4OXNCVkeHUh?=
KYSE-410	NIC4bpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEj2PG9KSzVyPUGwMlA3OTVizszN	MXPTRW5ITVJ?
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NB5	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXHJR\|UxRTFyLkW0NFUh\|ryP	NVTZOItMW0GQR1XS
NTERA-S-cl-D1	MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4[0UGlEPTB;MUCuOVQ4PSEQvF2=	M4XuTHNCVkeHUh?=
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SF539	M{W2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmGxTWM2OD1zMD63NVg5KM7:TR?=	M1:xenNCVkeHUh?=
CAL-120	MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3LtPWlEPTB;MUCuO\|U6PyEQvF2=	M2XBXnNCVkeHUh?=
GR-ST	NFSye45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFS2U\|hKSzVyPUGxMlI6QCEQvF2=	M4\XRnNCVkeHUh?=
IA-LM	NVr2TY9yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2PDc2lEPTB;MUGuN\|Q5PiEQvF2=	NWTndVZ1W0GQR1XS
NCI-H2452	NHrYUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYTNU4RtUUN3ME2xNU4{QTJ5IN88US=>	M{WxVnNCVkeHUh?=
NCI-H1648	NELQVoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUPJR\|UxRTFzLkS2Nlkh\|ryP	MoXHV2FPT0WU
YH-13	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2LrVmlEPTB;MUGuOFc1OiEQvF2=	M{DzcnNCVkeHUh?=
NCI-H2228	NX7rSY5FT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3XJN2lEPTB;MUGuOFkzQCEQvF2=	NHfJUmhUSU6JRWK=
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647-V	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mnj1TWM2OD1zMT61PVc1KM7:TR?=	MVzTRW5ITVJ?
HCC1806	MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFTKN3JKSzVyPUGxMlYyOzRizszN	M3jRcnNCVkeHUh?=
HPAF-II	MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHzDSphKSzVyPUGxMlg{PTZizszN	M4C3bHNCVkeHUh?=
BB49-HNC	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHznR\|BKSzVyPUGxMlg{PzVizszN	NX;ac5FJW0GQR1XS
KGN	MmP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmPlTWM2OD1zMT64OVg6KM7:TR?=	NFjsVJZUSU6JRWK=
NOMO-1	Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NE[1NVFKSzVyPUGxMlg2QTdizszN	NFjye4VUSU6JRWK=
A388	MmXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTFzLki4NFgh\|ryP	NX;V[2FTW0GQR1XS
Saos-2	NF\zPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTF{LkKwNFMh\|ryP	NH\2VohUSU6JRWK=
SK-HEP-1	MlXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTF{LkK2NVMh\|ryP	NHz2OFZUSU6JRWK=
HCE-4	NGD2fodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWLMNlV1UUN3ME2xNk4zPjl7IN88US=>	MnnBV2FPT0WU
NCI-H1581	NFLzPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3;tXWlEPTB;MUKuNlgyQSEQvF2=	M{TJNXNCVkeHUh?=
NCI-H23	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3f1SGlEPTB;MUKuN\|EzPSEQvF2=	M4DJfnNCVkeHUh?=
NCI-H596	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVfNcoZWUUN3ME2xNk41Pzl6IN88US=>	NWHpXXc{W0GQR1XS
NB69	Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfae5FuUUN3ME2xNk44PTh3IN88US=>	MUnTRW5ITVJ?
ChaGo-K-1	NYPBe2IzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml3FTWM2OD1zMj63OlQ6KM7:TR?=	NE\yU2RUSU6JRWK=
EFM-19	NFrxfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mm\STWM2OD1zMj63O\|E4KM7:TR?=	MkfHV2FPT0WU
SW962	Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVTW[5RXUUN3ME2xNk45OjJ\|IN88US=>	M3zJTnNCVkeHUh?=
KALS-1	NH3Cc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MluxTWM2OD1zMz6wPVUh\|ryP	NYTUfYdLW0GQR1XS
MDA-MB-415	MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkW4TWM2OD1zMz6xOlA6KM7:TR?=	MojKV2FPT0WU
SW684	NGP6[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF\ZUJVKSzVyPUGzMlE5PjFizszN	NGfRcnpUSU6JRWK=
NCI-H2052	NEP2fJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVTJR\|UxRTF\|LkO4OFgh\|ryP	MoDHV2FPT0WU
HOP-92	NEXibFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NV:zOlBGUUN3ME2xN{44QTl5IN88US=>	M3fuNXNCVkeHUh?=
OE19	NITNenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIPhfItKSzVyPUG0MlAxPzVizszN	NUi2O4xsW0GQR1XS
D-392MG	M{X6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmK0TWM2OD1zND6xNlEyKM7:TR?=	M3nINXNCVkeHUh?=
A253	NI\GdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWjvO3dKUUN3ME2xOE4zOjVizszN	M4TkPXNCVkeHUh?=
NCI-H1155	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nZUGlEPTB;MUSuNlc1PyEQvF2=	M1vKOnNCVkeHUh?=
SNB75	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2ixOWlEPTB;MUSuN\|g6OyEQvF2=	NWPsW45kW0GQR1XS
23132-87	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWTJR\|UxRTF2LkizOVMh\|ryP	MknrV2FPT0WU
Calu-3	Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2e3dWlEPTB;MUSuPFc1OyEQvF2=	M13QR3NCVkeHUh?=
CW-2	M3X0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmTUTWM2OD1zNT6wNlI{KM7:TR?=	MYnTRW5ITVJ?
COLO-679	NFPQN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NILQcmhKSzVyPUG1MlExOTNizszN	NV3sc49qW0GQR1XS
NCI-SNU-5	NVrmc2RxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWrJR\|UxRTF3LkW1PFkh\|ryP	NFHlWnlUSU6JRWK=
AN3-CA	M17xXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1[xNGlEPTB;MUWuOlQ3QCEQvF2=	MlTuV2FPT0WU
SF126	NIjjSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYnJR\|UxRTF3LkeyPFUh\|ryP	MXTTRW5ITVJ?
D-247MG	M4XxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{H5b2lEPTB;MUWuPFU{OyEQvF2=	MVPTRW5ITVJ?
UACC-62	M3LBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1q1VGlEPTB;MUWuPVY3KM7:TR?=	NUTOfHZ6W0GQR1XS
GP5d	M4S4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXPJR\|UxRTF4LkGxO\|Eh\|ryP	MoDzV2FPT0WU
HuO-3N1	NILrfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfy[o06UUN3ME2xOk4zPDd\|IN88US=>	MV\TRW5ITVJ?
NCI-H1092	M3e3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIeySIpKSzVyPUG2MlYzQTdizszN	MYnTRW5ITVJ?
HCC1187	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXHVPI5VUUN3ME2xOk43PTV5IN88US=>	NXS5eFNSW0GQR1XS
G-402	M1ixT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MofTTWM2OD1zNj64OVY2KM7:TR?=	NXTpdW0zW0GQR1XS
HT55	M4nGOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlraTWM2OD1zNj64O\|UyKM7:TR?=	NXLFemRNW0GQR1XS
NCI-H2009	NEjEcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2\vSmlEPTB;MU[uPVI3PiEQvF2=	MmnqV2FPT0WU
SH-4	M3v6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1H6dWlEPTB;MU[uPVkzKM7:TR?=	NITwO5JUSU6JRWK=
SW1783	MlvuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFnsW2xKSzVyPUG2Mlk6QThizszN	NHq3bWJUSU6JRWK=
HT	Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXTJR\|UxRTF5LkG5OlQh\|ryP	M2HIfnNCVkeHUh?=
CP66-MEL	M3\mcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXTJR\|UxRTF5LkOwNUDPxE1?	M1vibXNCVkeHUh?=
BEN	NGTMS45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2O5bGlEPTB;MUeuOVYzPiEQvF2=	MVXTRW5ITVJ?
HCC38	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVXPNYZZUUN3ME2xO{44Pjl6IN88US=>	MWPTRW5ITVJ?
LAN-6	NILFTWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MknTTWM2OD1zNz64OFg2KM7:TR?=	NET3RZNUSU6JRWK=
RERF-LC-MS	MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX3JR\|UxRTF5LkmxNlkh\|ryP	M2jaeXNCVkeHUh?=
NCI-H1770	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWTJR\|UxRTF5Lkm0PVEh\|ryP	NVvyVpY1W0GQR1XS
LCLC-103H	Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXXSSnByUUN3ME2xPE4xPTFizszN	M132SHNCVkeHUh?=
NCI-H520	MojwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2nnTmlEPTB;MUiuN\|I5OSEQvF2=	MVfTRW5ITVJ?
LU-65	Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTF6LkSwOFMh\|ryP	NEDabHpUSU6JRWK=
SK-MEL-3	NXjEfIp7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M17zZmlEPTB;MUiuOlY4QSEQvF2=	NU\4c25[W0GQR1XS
LK-2	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NG\Bc3RKSzVyPUG4Mlc4OjNizszN	NGTseotUSU6JRWK=
PANC-08-13	Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTF6Lke4PFkh\|ryP	MnHRV2FPT0WU
NCI-H460	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mkj6TWM2OD1zOD64OFY3KM7:TR?=	NHnMfmdUSU6JRWK=
COLO-684	MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHfFbZNKSzVyPUG4Mlk6PTZizszN	M2rBNHNCVkeHUh?=
RPMI-2650	M133WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXnJR\|UxRTF7LkCxNkDPxE1?	NIPmfI1USU6JRWK=
NY	NX\ZWW5oT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXn5XYhZUUN3ME2xPU4yPTZ5IN88US=>	NEjsZ2VUSU6JRWK=
NB7	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3v4T2lEPTB;MUmuNVc2OyEQvF2=	NHHrUmhUSU6JRWK=
NCI-H358	NHnYWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mk\sTWM2OD1zOT6yOlc{KM7:TR?=	M{HYPXNCVkeHUh?=
MC116	M3LhVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MY\JR\|UxRTF7LkWzN\|Eh\|ryP	MWXTRW5ITVJ?
MS-1	NEjmXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYPJR\|UxRTF7Lk[xNFMh\|ryP	MYXTRW5ITVJ?
NCI-H82	NUe4THlHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4XkZWlEPTB;MUmuOlg4QCEQvF2=	M3LYdHNCVkeHUh?=
OCI-AML2	NFu1R3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWG4flVOUUN3ME2xPU44ODN{IN88US=>	MoD5V2FPT0WU
LS-123	MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTJyLkCxPVQh\|ryP	NIPrSmRUSU6JRWK=
PC-14	NYrVNpoyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIeydnhKSzVyPUKwMlE5OzRizszN	M3r2NXNCVkeHUh?=
NCI-H1703	MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{\BTmlEPTB;MkCuPFE4OyEQvF2=	NFLiZm5USU6JRWK=
Calu-6	NFSyNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV7JR\|UxRTJzLkGwNFUh\|ryP	MYXTRW5ITVJ?
no-11	NX:0cGVWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUnnPFlpUUN3ME2yNU4yPjB{IN88US=>	NVvIVFNRW0GQR1XS
NCI-H727	MoDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3\H[WlEPTB;MkGuN\|Q6OyEQvF2=	NUTLVZhCW0GQR1XS
DSH1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NInuVndKSzVyPUKxMlM5PzlizszN	MXTTRW5ITVJ?
KYSE-140	M3r5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVLJR\|UxRTJzLkeyO\|Eh\|ryP	NIXRS4ZUSU6JRWK=
RH-1	NEXpV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXfJR\|UxRTJzLki4N{DPxE1?	NWLRfYNiW0GQR1XS
HAL-01	NHHOXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWPJR\|UxRTJ{LkC0NVgh\|ryP	NIHBepVUSU6JRWK=
RXF393	MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2H5fWlEPTB;MkKuNlc5QSEQvF2=	M3\YNnNCVkeHUh?=
LS-411N	NY\rU4tQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3qxNGlEPTB;MkKuNlg3QSEQvF2=	MoPJV2FPT0WU
no-10	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHPEc5hKSzVyPUKyMlUxODRizszN	NUjaV25WW0GQR1XS
MKN7	NH:4bXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHZdY8yUUN3ME2yNk43QDdizszN	MV\TRW5ITVJ?
AU565	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NX;EOZg2UUN3ME2yNk44PDd6IN88US=>	NYTVdolWW0GQR1XS
NUGC-3	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWDJR\|UxRTJ\|LkGxPVkh\|ryP	M2m5V3NCVkeHUh?=
EW-16	M1PkcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3TxWGlEPTB;MkSuNFkzPiEQvF2=	MUDTRW5ITVJ?
HCC70	M3vl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFTaRmFKSzVyPUK0MlE{OjNizszN	NVLkWYt3W0GQR1XS
RPMI-8226	NIrRcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MW\JR\|UxRTJ2LkOxOVUh\|ryP	MV7TRW5ITVJ?
CFPAC-1	M{f5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{nKdmlEPTB;MkSuOlI4OiEQvF2=	MV\TRW5ITVJ?
DoTc2-4510	NVL1eZdkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MorNTWM2OD1{ND63OVc2KM7:TR?=	NI[1c3dUSU6JRWK=
KNS-62	NXfNRldUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHrPUZNKSzVyPUK1MlAyQCEQvF2=	M3\lcXNCVkeHUh?=
SK-N-DZ	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NULl[GpQUUN3ME2yOU4xQTB2IN88US=>	MVjTRW5ITVJ?
CAL-85-1	Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn;1TWM2OD1{NT6xOVQ1KM7:TR?=	M1HENHNCVkeHUh?=
JVM-2	M33zZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml7PTWM2OD1{NT6yNVIzKM7:TR?=	M1n1RnNCVkeHUh?=
NCI-H2347	M2TiOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHexNWlKSzVyPUK1MlQzPDlizszN	MkDHV2FPT0WU
P30-OHK	NHTSXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NI\W[GNKSzVyPUK1MlY{OThizszN	NHKyVpFUSU6JRWK=
SK-N-FI	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmH6TWM2OD1{Nj6xNVYzKM7:TR?=	MXjTRW5ITVJ?
CAMA-1	NYPDSZg6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkjHTWM2OD1{Nj60PFc3KM7:TR?=	MXXTRW5ITVJ?
MHH-NB-11	NWnveo9YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mnn1TWM2OD1{Nj61PFUyKM7:TR?=	NIPJNW5USU6JRWK=
IST-MEL1	NUTMe4k2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1fGOmlEPTB;Mk[uO\|E4PyEQvF2=	MWPTRW5ITVJ?
KARPAS-299	M{Tqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2PWS2lEPTB;MkeuOFcxOSEQvF2=	NWXp[\|M4W0GQR1XS
TE-11	M2W2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mmf3TWM2OD1{Nz63N\|QzKM7:TR?=	NVvVUFV4W0GQR1XS
769-P	NELTTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYnXWIdEUUN3ME2yPE41PTN\|IN88US=>	MkC0V2FPT0WU
CAL-72	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVzqe41tUUN3ME2yPE42PTZzIN88US=>	M3zuNnNCVkeHUh?=
NCI-H2342	NVu5R3FPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkC2TWM2OD1{OT6zPFA{KM7:TR?=	NV\2UY9rW0GQR1XS
NCI-H1651	MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUGyPWpuUUN3ME2yPU45PTB\|IN88US=>	MoLxV2FPT0WU
OE33	NGr1co5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXvJR\|UxRTNyLkGzOFIh\|ryP	NGWybFNUSU6JRWK=
HuP-T4	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTVTWM2OD1\|MT60PFM4KM7:TR?=	MY\TRW5ITVJ?
U-118-MG	M4rnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXnaXmZEUUN3ME2zNk42PDRzIN88US=>	MV3TRW5ITVJ?
SN12C	NEL4OWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFLaPVNKSzVyPUOyMlg5OTVizszN	M1fONHNCVkeHUh?=
TE-5	NI\4N41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkewTWM2OD1\|Mz6xN\|Y5KM7:TR?=	M1\COHNCVkeHUh?=
KM-H2	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkP0TWM2OD1\|Mz6xOlk6KM7:TR?=	NHzETZVUSU6JRWK=
OVCAR-3	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmHzTWM2OD1\|Mz60NVI4KM7:TR?=	NWHMV\|NmW0GQR1XS
NCI-H1304	M1vYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIniSZpKSzVyPUOzMlYxOzZizszN	M{PMd3NCVkeHUh?=
LU-135	MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NF;6S4dKSzVyPUOzMlcxQDZizszN	NGrY[\|BUSU6JRWK=
S-117	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUewS29GUUN3ME2zN{44Ojh4IN88US=>	M3X5PHNCVkeHUh?=
NCI-H1755	NY[2W5M2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2LTT2lEPTB;M{OuPFEyKM7:TR?=	MnnSV2FPT0WU
Mo-T	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NU\RPY9mUUN3ME2zN{45PTl\|IN88US=>	MW\TRW5ITVJ?
SK-OV-3	M1\ZOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYm4UGVEUUN3ME2zN{45QDV2IN88US=>	NGW5cGtUSU6JRWK=
RCC10RGB	NWrv[\|I2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWfwVINkUUN3ME2zN{46PDN\|IN88US=>	M2Li[3NCVkeHUh?=
COLO-680N	M3jEbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M{i3[WlEPTB;M{SuNVM6PyEQvF2=	NHzSdnpUSU6JRWK=
KURAMOCHI	M3jt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mlz0TWM2OD1\|ND62OFI2KM7:TR?=	NVPhRmdbW0GQR1XS
NCI-H661	NHPTO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MorvTWM2OD1\|ND64OFQ5KM7:TR?=	MWPTRW5ITVJ?
YAPC	MnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUTsepNFUUN3ME2zOU46PTN\|IN88US=>	NGjvUVJUSU6JRWK=
NCI-H526	NFPadGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHfFfGVKSzVyPUO3MlI4PzJizszN	NIX0VpBUSU6JRWK=
A498	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2\oNmlEPTB;M{iuNFk2PCEQvF2=	M4fiT3NCVkeHUh?=
VMRC-RCZ	NF\mXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVnRXZZZUUN3ME2zPU4xODV2IN88US=>	M2PacnNCVkeHUh?=
HCT-116	MkjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYrJR\|UxRTN7LkC1PEDPxE1?	M3zQenNCVkeHUh?=
COLO-320-HSR	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MW\JR\|UxRTRyLkC0NUDPxE1?	M{H1R3NCVkeHUh?=
OAW-42	M2jOemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4XjOGlEPTB;NECuNFU1OiEQvF2=	NXHEb5JFW0GQR1XS
SK-MEL-1	NIruSmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGTsc5pKSzVyPUSwMlI6OjdizszN	M3nuWnNCVkeHUh?=
IST-MES1	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3nWZWlEPTB;NECuO\|Y2OyEQvF2=	NVLTU\|AxW0GQR1XS
CP50-MEL-B	MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{LLO2lEPTB;NEGuNFc6PyEQvF2=	NVjCZopJW0GQR1XS
RMG-I	NYfQcm1lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUf3NWk3UUN3ME20Nk41QTJzIN88US=>	MUTTRW5ITVJ?
D-336MG	NFfFNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmjtTWM2OD12Mz6xNVUzKM7:TR?=	MnnZV2FPT0WU
SHP-77	M3Ts[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTR\|LkG4Nlgh\|ryP	NUG0TYFXW0GQR1XS
SW872	NHXYcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Moe0TWM2OD12Mz6yNVI{KM7:TR?=	MYDTRW5ITVJ?
DBTRG-05MG	MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NIfzcHNKSzVyPUS0MlY6QTZizszN	MWfTRW5ITVJ?
COLO-678	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTzUm5KSzVyPUS1MlcxOzJizszN	M{\tTXNCVkeHUh?=
EGI-1	NXywNnlrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVHJR\|UxRTR5LkG4N\|Mh\|ryP	MUXTRW5ITVJ?
KYSE-70	NHXxXo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHTxRlRKSzVyPUS3MlczOjJizszN	NFj5NXZUSU6JRWK=
BALL-1	NI\VfIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2TuPGlEPTB;NEeuPFI2PCEQvF2=	NWPoW2xuW0GQR1XS
MDA-MB-361	MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFvCN\|JKSzVyPUS4MlA1PiEQvF2=	NEjHZ41USU6JRWK=
NCI-H1838	NW\CdW95T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlvJTWM2OD12OD6zOFU5KM7:TR?=	NGXXTnlUSU6JRWK=
NCI-H1573	NYXuWJZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX7rTXQ3UUN3ME20PE43Pzh3IN88US=>	MWDTRW5ITVJ?
HCC1395	NH3LZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmHBTWM2OD12OD65PVIh\|ryP	NGewdFhUSU6JRWK=
NCI-H2291	M3vwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYPCbVhRUUN3ME20PU42QTh6IN88US=>	MnnDV2FPT0WU
RH-18	MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkH2TWM2OD13MD6wPFg1KM7:TR?=	MXvTRW5ITVJ?

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Assay

Methods	Test Index	PMID
Western blot	p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1 ; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (PS102-YB-1, PS112-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis. p-GSK3 / p-ERK / ERK / p-CREB / CREB / p-S6 / p-LKB1 / LKB1; PubMed: 17040210 Biochem J (A) HEK-293 cells that had been deprived of serum for 16 h, were incubated in the absence or presence of 10 μM BI-D1870 for the indicated times, then stimulated with 400 ng/ml PMA (TPA) for 20 min. The cells were lysed and the lysates were immunoblotted with the indicated antibodies as described in the Materials and methods section. (B) As in (A), except that cells were incubated for 30 min with the indicated concentrations of BI-D1870 prior to stimulation with PMA. Similar results were obtained in two separate experiments. p-YB1 / YB1 / p-Bad / Bad / p-RSK / RSK ; PubMed: 28415756 Oncotarget Western Blot analysis of RSK activity (P(S102)-YB-1, P(S112)-Bad) of double resistant SKMel28 RR after treatment with increasing concentrations of BI-D1870 for 24 h. GAPDH was detected as a loading control. IRF4 / MYC / MCL-1 / PARP ; PubMed: 25395420 Blood (B) H929 cells were incubated with BI-D1870 (BI, 3 μM) at indicated time points, followed by immunoblotting analysis. (C) JJN3 cells were incubated with BI-D1870 at indicated doses for 6 hours, followed by immunoblotting analysis.	17040210 28415756 25395420
Immunofluorescence	PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in E were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei. PDCD4 / F-actin ; PubMed: 25002506 Proc Natl Acad Sci U S A A375 cells treated as in (E) were imaged using immunofluorescence microscopy. Cells were stained with anti-PDCD4 antibodies to visualize endogenous PDCD4, phalloidin to visualize F-actin, and DAPI to visualize nuclei.	25002506
Growth inhibition assay	Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls. Cell viability; PubMed: 28415756 Oncotarget (D–F) Cell viability (MUH assay) of double resistant melanoma cells after a 72 h-treatment with increasing concentrations of vemurafenib (D), trametinib (E) or vemurafenib and trametinib (F), as well as of BI-D1870 and the combination of MAPK inhibitors and BI-D1870 (n = 6; mean ± SD). Signals were normalized to the DMSO-treated controls.	28415756

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A
Smiles	CC(C)CCN1C(C)C(=O)N(C)C2=C1N=C(NC3=CC(=C(O)C(=C3)F)F)N=C2

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

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