BI-D1870

Catalog No.S2843

BI-D1870 Chemical Structure

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

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4 Customer Reviews

  • Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

    Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

    (g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

    Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.

  • HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

    Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

    Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

    J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Targets
RSK4 [1]
(Cell-free assay)
RSK3 [1]
(Cell-free assay)
RSK2 [1]
(Cell-free assay)
RSK1 [1]
(Cell-free assay)
15 nM 18 nM 24 nM 31 nM
In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
EW-3 NID1NpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfBSndKSzVyPUCuNFM2QCEQvF2= MmjIV2FPT0WU
H9 M3j3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzwdHdWUUN3ME2wMlA3ODF7IN88US=> NUTBcJRnW0GQR1XS
KARPAS-45 MmDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDDO4NjUUN3ME2wMlE3PTJ3IN88US=> MYjTRW5ITVJ?
NCI-H720 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jMdmlEPTB;MD6xO|E6PCEQvF2= MoflV2FPT0WU
CTV-1 NGqwTZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwNEe4O|Ih|ryP Mk\RV2FPT0WU
DU-4475 NIP2VXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwNUC0NVch|ryP MkfwV2FPT0WU
A172 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNUG3NFUh|ryP MnfiV2FPT0WU
EW-18 M2C5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvrOHhtUUN3ME2wMlYzOjFzIN88US=> MUfTRW5ITVJ?
KU812 NH\sdnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rGZWlEPTB;MD62NlYzOyEQvF2= NHi5Oo5USU6JRWK=
KP-N-YS MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLZTWM2OD1yLk[4NlI{KM7:TR?= M4P5RnNCVkeHUh?=
SBC-1 NV30eXhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrBSlBKSzVyPUCuOlk2OjRizszN NUPR[ZlzW0GQR1XS
ECC10 M3zNb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHnTWM2OD1yLkewNFk1KM7:TR?= NILXNINUSU6JRWK=
GAMG M4H5dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXNXJdUUUN3ME2wMlc1PzF5IN88US=> NX6wbJdvW0GQR1XS
NCI-H209 NHfvXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;0TWM2OD1yLke2PFIh|ryP NXfxcJlPW0GQR1XS
MC-IXC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwN{m1PFkh|ryP M2njeXNCVkeHUh?=
HSC-3 NUj4bnBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE[wXY9KSzVyPUCuPFE4PjlizszN NYXaWoVoW0GQR1XS
IST-SL1 NXj1cFQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwOES1O|Qh|ryP NX75R|d1W0GQR1XS
LU-139 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOyTWM2OD1yLki0PVU5KM7:TR?= NYrWO4pyW0GQR1XS
ML-2 NYH0N2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPpTWM2OD1yLki1OVc2KM7:TR?= NGTiW4RUSU6JRWK=
CAL-62 NEH3fWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGT5eVNKSzVyPUCuPFgyPTJizszN Ml7lV2FPT0WU
HL-60 M{jWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwOEizOlIh|ryP M4GxXnNCVkeHUh?=
KY821 NGfVVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXz[GNKSzVyPUCuPFg5OTJizszN NVPF[GxTW0GQR1XS
ES7 M3WxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHPcHdqUUN3ME2wMlkyPjB5IN88US=> MnfuV2FPT0WU
MV-4-11 M{PIc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq4Oo9KSzVyPUCuPVc5QTdizszN M{G1PHNCVkeHUh?=
Daoy NGrFRlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnuVY5KSzVyPUCuPVg4PjdizszN MVXTRW5ITVJ?
EoL-1-cell NWLMbGFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Nfm1VUUN3ME2xMlAyQDd6IN88US=> MVTTRW5ITVJ?
TGW NGLhUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfR[ZpNUUN3ME2xMlA2OTJ2IN88US=> M{PsfnNCVkeHUh?=
LAMA-84 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XhdmlEPTB;MT6xNlc6PCEQvF2= M3zHdnNCVkeHUh?=
KOSC-2 NIH2R3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PkemlEPTB;MT6xN|M5PSEQvF2= NXXxT|c3W0GQR1XS
A549 NUS2R|RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTFwM{C5OVUh|ryP Ml;JV2FPT0WU
CTB-1 NITNZZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHKVWhQUUN3ME2xMlQ1Pjd7IN88US=> MkLtV2FPT0WU
NCI-H292 NGS5ZWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwNE[wOlkh|ryP M4C5bXNCVkeHUh?=
LoVo MnLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jtVGlEPTB;MT60Olc2PSEQvF2= NETZZllUSU6JRWK=
BFTC-905 NUTjSIhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7lTWM2OD1zLkW2N|MzKM7:TR?= MkXsV2FPT0WU
BE-13 NW\2NYtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvNWZpKSzVyPUGuOVg4ODlizszN NXLzenpxW0GQR1XS
KE-37 NVPROYZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTFwNUm0O|gh|ryP M3XjUXNCVkeHUh?=
HN NYq5dGVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnrNFBKSzVyPUGuOlE{PjhizszN NWLIcoF4W0GQR1XS
A3-KAW MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTjTWM2OD1zLk[yPFM1KM7:TR?= MoXhV2FPT0WU
NEC8 NUK3S3IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfuTWM2OD1zLkewNVE2KM7:TR?= NX3lTZpPW0GQR1XS
Ramos-2G6-4C10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXSTWM2OD1zLkewOFQ1KM7:TR?= M2j2UXNCVkeHUh?=
NB10 NYnLV|cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nZ[GlEPTB;MT63O|Y{KM7:TR?= MVvTRW5ITVJ?
NBsusSR M4H0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37CTGlEPTB;MT64Nlk3OSEQvF2= MkjMV2FPT0WU
ES4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTXTWM2OD1zLki1NVQ{KM7:TR?= NEnafXZUSU6JRWK=
ES8 NWjRVXp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLZRm9LUUN3ME2xMlg4PzJ2IN88US=> NF\ZOmJUSU6JRWK=
CHL-1 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrncZpVUUN3ME2xMlk2Pzl{IN88US=> MUfTRW5ITVJ?
NCI-H2029 M1L3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVraRYV6UUN3ME2xMlk4OjRzIN88US=> NE\ZWHRUSU6JRWK=
YKG-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXrV5JYUUN3ME2xMlk5PDN{IN88US=> NHr5fYpUSU6JRWK=
BV-173 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWW5S5Q5UUN3ME2xMlk5PjZ4IN88US=> NHjmemtUSU6JRWK=
697 NH\BRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HIV2lEPTB;Mj6wNlIzQCEQvF2= NHTiN5hUSU6JRWK=
SK-NEP-1 NIqxSm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7ZPXdKSzVyPUKuNFQ1KM7:TR?= NXzz[3I3W0GQR1XS
LOXIMVI Mn;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPXTWM2OD1{LkC0OFM1KM7:TR?= MYPTRW5ITVJ?
QIMR-WIL M2j2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjITWM2OD1{LkC3PFQ6KM7:TR?= NUXvZYNXW0GQR1XS
DU-145 M{XId2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXad|RSUUN3ME2yMlEyODV4IN88US=> M1flfHNCVkeHUh?=
NB14 NYjKN2N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DK[2lEPTB;Mj6xNVMzOSEQvF2= MV3TRW5ITVJ?
G-361 M2jk[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zuWGlEPTB;Mj6xNlIyKM7:TR?= M2PMcnNCVkeHUh?=
BPH-1 NUnmeIpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnRTWM2OD1{LkGyPVU4KM7:TR?= MlLzV2FPT0WU
KYSE-150 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwMUWyN|Qh|ryP MnnyV2FPT0WU
HMV-II M3G3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTJwMU[2N|Mh|ryP NF3CXG9USU6JRWK=
TE-9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzzc5NFUUN3ME2yMlE4Ozd4IN88US=> NIP4cZpUSU6JRWK=
8-MG-BA NIW4b5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwMkO0OlEh|ryP NWe0R|M3W0GQR1XS
ES5 NXH3b2lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jvV2lEPTB;Mj6yN|Y{OyEQvF2= NVvHfYhmW0GQR1XS
D-283MED NFXEWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXiTmtFUUN3ME2yMlI{Pjl3IN88US=> NUWwR|RVW0GQR1XS
SK-N-AS NFXzWHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS3TplDUUN3ME2yMlI6ODV7IN88US=> M1jPbXNCVkeHUh?=
SW1710 MnLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXDdFdKSzVyPUKuN|A3PjFizszN MVXTRW5ITVJ?
GCT NIPiRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnDO|FrUUN3ME2yMlMyOzV6IN88US=> NXPmRW9WW0GQR1XS
AGS M3Hib2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC0TWM2OD1{LkO0OFA1KM7:TR?= NWXONHVJW0GQR1XS
HuO9 NX\JO|M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJwM{[4NlQh|ryP M{fNUnNCVkeHUh?=
MN-60 M4LoS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD1ZlNoUUN3ME2yMlQ1QDh|IN88US=> NXrHbGU6W0GQR1XS
NB6 Mnv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDmTWM2OD1{LkS1O|c6KM7:TR?= M2L5OnNCVkeHUh?=
NCI-H1395 NHrZRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4izNGlEPTB;Mj60O|EzOSEQvF2= Ml;2V2FPT0WU
H4 M1e0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\GVYNKSzVyPUKuOFg{QTNizszN NFXXSXpUSU6JRWK=
HT-3 NFnvPXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17MR2lEPTB;Mj61NVAzPCEQvF2= NIDwXlBUSU6JRWK=
P12-ICHIKAWA MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvnRmF2UUN3ME2yMlUzPTV7IN88US=> MnTzV2FPT0WU
COLO-800 M2fldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwNUSxOlYh|ryP MU\TRW5ITVJ?
DB NUDaTYVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIn5fI9KSzVyPUKuOVUxOTNizszN MXfTRW5ITVJ?
LCLC-97TM1 M4To[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zaT2lEPTB;Mj62NFAzQCEQvF2= NHLCeI9USU6JRWK=
Ca9-22 NYnNTmRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7CTWM2OD1{Lk[1PVM{KM7:TR?= NYLCZXhGW0GQR1XS
Becker NEjHXFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS4TWM2OD1{Lk[2NFc5KM7:TR?= M{XiVnNCVkeHUh?=
ACN NYfoZ2J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P2UmlEPTB;Mj62Olc6KM7:TR?= M3my[HNCVkeHUh?=
SJSA-1 MnfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;obmx6UUN3ME2yMlY3QDdizszN NVzqWpBTW0GQR1XS
NCI-H1048 M2DlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHzTWM2OD1{Lk[4N|IyKM7:TR?= NX6zWYE5W0GQR1XS
HEL MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvuWFhoUUN3ME2yMlcxOjV2IN88US=> NYPKNZBuW0GQR1XS
NCI-H69 M1XmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vINGlEPTB;Mj63NVYxOSEQvF2= NG\pdIhUSU6JRWK=
639-V NGPpeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITxVXJKSzVyPUKuO|E4ODNizszN M3rKT3NCVkeHUh?=
U251 NHH2NHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nPR2lEPTB;Mj63N|A{OiEQvF2= NHLXVlZUSU6JRWK=
NCI-H1792 NEe0NmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFuxTlJKSzVyPUKuO|M4OzhizszN NYPpPJJPW0GQR1XS
EW-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTJwN{WzNlgh|ryP MV3TRW5ITVJ?
ME-180 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7mTWM2OD1{Lke3O|M3KM7:TR?= Mk\rV2FPT0WU
HH MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJwOECwNFEh|ryP MYDTRW5ITVJ?
SW954 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XCcGlEPTB;Mj64OVg{KM7:TR?= NYXFeodxW0GQR1XS
SF268 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfNeIRKSzVyPUKuPFczOjVizszN MlHlV2FPT0WU
D-566MG M3PrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJwOUGyPVUh|ryP M3P3RnNCVkeHUh?=
EM-2 M1vPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j4R2lEPTB;Mj65NlE6OyEQvF2= M4\oW3NCVkeHUh?=
NCI-H1299 NGDHU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL6[pFZUUN3ME2yMlk{PzN4IN88US=> NIPxO4FUSU6JRWK=
PSN1 NEf5NZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T6TmlEPTB;Mz6wOVc5PiEQvF2= Mlv4V2FPT0WU
JVM-3 NVLoOlJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLsNlNKSzVyPUOuNFY4PTZizszN M4mxTHNCVkeHUh?=
D-502MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSzRotKSzVyPUOuNFcxOTlizszN MX\TRW5ITVJ?
SCC-4 M1O4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HrfGlEPTB;Mz6wPVI4PiEQvF2= Mn72V2FPT0WU
GMS-10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPtb45OUUN3ME2zMlA6Ozh6IN88US=> NF\qVYpUSU6JRWK=
A427 NHXncmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmr6TWM2OD1|LkGwPFc{KM7:TR?= NHvTZpVUSU6JRWK=
NH-12 NHexWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTNwMUG0OVYh|ryP NH[0OohUSU6JRWK=
KM12 NYHBbHY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrBTJJKSzVyPUOuNVIzPzNizszN MmjhV2FPT0WU
GI-1 M3;V[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P0W2lEPTB;Mz6xOVI2PSEQvF2= M{[4cXNCVkeHUh?=
TE-8 M1f1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXUU4txUUN3ME2zMlE6OjNzIN88US=> MWXTRW5ITVJ?
MKN1 NXrqTpBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzz[5ZKSzVyPUOuNlA5PzVizszN NV7xR5pCW0GQR1XS
NCI-H810 NVfscZo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n3dWlEPTB;Mz6yNlE2PSEQvF2= MUXTRW5ITVJ?
GOTO MmDFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml20TWM2OD1|LkK4NFA1KM7:TR?= MXLTRW5ITVJ?
T98G MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnlXGFKSzVyPUOuNlgzOTZizszN M1zXXHNCVkeHUh?=
HD-MY-Z NX7KVmw{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK5TWM2OD1|LkO2OVQzKM7:TR?= NVmwTol4W0GQR1XS
SNU-C2B NVXOW2R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXIeGtKSzVyPUOuN|kxQTdizszN NUPlSYVkW0GQR1XS
MOLT-4 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTNwM{mwPVgh|ryP MYnTRW5ITVJ?
RPMI-7951 NVzzTYlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nMRmlEPTB;Mz6zPVc{KM7:TR?= NUXB[oxtW0GQR1XS
EW-11 NVjT[G9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7qboVKSzVyPUOuOFEzOjRizszN MnfYV2FPT0WU
RD M2D3Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG5[JVKSzVyPUOuOFMyOzJizszN NH;INpNUSU6JRWK=
SW48 NX7tRY9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjjUGZKSzVyPUOuOFM{PThizszN MWnTRW5ITVJ?
BB65-RCC MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjxNmsxUUN3ME2zMlQ2Ozl4IN88US=> NHzr[|NUSU6JRWK=
Ca-Ski M1HZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTNwNEe1NVQh|ryP MYTTRW5ITVJ?
CHP-134 NWLnNFlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPETWM2OD1|LkS4O|U5KM7:TR?= NYHrcGczW0GQR1XS
CAL-33 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvSXHpoUUN3ME2zMlU{OzZ{IN88US=> Ml3aV2FPT0WU
TYK-nu NY[2[3JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTNwNUO2O|Yh|ryP M1H1UnNCVkeHUh?=
LB831-BLC NUP5S2NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;N[nFEUUN3ME2zMlU1ODF4IN88US=> NYHaW5JkW0GQR1XS
KU-19-19 NE\CNYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13LWGlEPTB;Mz62NFMxPCEQvF2= MVXTRW5ITVJ?
KG-1 NFXDbXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O3O2lEPTB;Mz62NVExPiEQvF2= NHPFeVhUSU6JRWK=
COLO-829 M3nkfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PScWlEPTB;Mz62OlYyQCEQvF2= NX3ZPG1xW0GQR1XS
HUTU-80 M4njNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nWUWlEPTB;Mz62OlYzOSEQvF2= MmPtV2FPT0WU
NCI-H446 NWL1[nNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDaTWM2OD1|Lk[4N|Qh|ryP NYPQdYpFW0GQR1XS
LB2241-RCC M{DPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTNwNki2NlUh|ryP MlLwV2FPT0WU
JEG-3 M2Todmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DOV2lEPTB;Mz62PVE6KM7:TR?= M3TVXXNCVkeHUh?=
LNCaP-Clone-FGC NV\HdldXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKwbW9CUUN3ME2zMlcxODRzIN88US=> Mm\PV2FPT0WU
M059J NF63[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fncmlEPTB;Mz63NVQ3QCEQvF2= NXvjRYJlW0GQR1XS
SK-MES-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLIeXFKSzVyPUOuO|MxOyEQvF2= NEXHSmRUSU6JRWK=
GT3TKB MmfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLycWdKSzVyPUOuO|U3ODRizszN NYqyeFd[W0GQR1XS
DOK MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXe1OI1qUUN3ME2zMlc3PTJ4IN88US=> MofNV2FPT0WU
HO-1-N-1 M{XPc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwN{m4NFEh|ryP M1:zTnNCVkeHUh?=
MZ1-PC M3;Ne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYryeIh3UUN3ME2zMlgzQDh|IN88US=> MknGV2FPT0WU
8305C MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjNZmRKSzVyPUOuPFg6PDNizszN M2XHUXNCVkeHUh?=
CGTH-W-1 NX;NcGtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNwOUO1NFQh|ryP MX7TRW5ITVJ?
LU-134-A MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXSOmx{UUN3ME2zMlk2PDJ{IN88US=> NEHvRnhUSU6JRWK=
C32 Mln2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jMWGlEPTB;Mz65OlU5OSEQvF2= MUHTRW5ITVJ?
MOLT-13 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTNwOU[4OVYh|ryP M1XMXXNCVkeHUh?=
A375 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfDfZhKSzVyPUSuNFUyPjJizszN NIDscVNUSU6JRWK=
CAL-12T MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF:zW4JKSzVyPUSuNFU4QTVizszN M3y2U3NCVkeHUh?=
IGR-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTRwMUCyO|Qh|ryP M2\TXnNCVkeHUh?=
LB1047-RCC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRwMUC0OFEh|ryP MWLTRW5ITVJ?
BHT-101 MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2zT3NKSzVyPUSuNVA3QDNizszN NEW3dotUSU6JRWK=
A431 MoHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r1emlEPTB;ND6xOFA5OSEQvF2= NXTPcZZ[W0GQR1XS
EPLC-272H NHHmNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV6xOohiUUN3ME20MlE4PTl4IN88US=> M1TQ[HNCVkeHUh?=
HT-1376 NGnLdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTRwMkOwOVkh|ryP NFi3O4pUSU6JRWK=
HCC1954 MkHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTRwMkW3OFYh|ryP MVPTRW5ITVJ?
KYSE-510 M4HqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jYNGlEPTB;ND6yOlA6KM7:TR?= NU\CbmhbW0GQR1XS
PANC-03-27 NFKxVmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;zTWM2OD12LkOwNFg{KM7:TR?= NHHjfGZUSU6JRWK=
MDA-MB-157 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTRwM{C2OVYh|ryP NFnh[mVUSU6JRWK=
HOP-62 M4KxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXxbHBKSzVyPUSuN|A5PTZizszN M1j1WXNCVkeHUh?=
ETK-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTRwM{[yNFMh|ryP MlvGV2FPT0WU
MIA-PaCa-2 NHHQWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:1b2JKSzVyPUSuN|YzOjdizszN NWX5UHVEW0GQR1XS
MHH-PREB-1 Mn3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33QNmlEPTB;ND6zPVc4OyEQvF2= MXPTRW5ITVJ?
LXF-289 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nacmlEPTB;ND60NFIxOiEQvF2= M1vKNnNCVkeHUh?=
ATN-1 NF\jb4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnPeXVKSzVyPUSuOFI{PDFizszN NGnhfZVUSU6JRWK=
8505C NVnRWWFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTRwNEW4NlUh|ryP NI\uWYtUSU6JRWK=
HOS NVfYS|ZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP1TY9FUUN3ME20MlQ3PDV|IN88US=> MnLOV2FPT0WU
U-266 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjQTWM2OD12Lk[xNFMzKM7:TR?= MkLnV2FPT0WU
5637 NGm3eWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD3TWM2OD12Lk[xOFQ1KM7:TR?= NWe4Z4VqW0GQR1XS
GCIY NXnzeJRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnESWoyUUN3ME20MlcyODF3IN88US=> M2LvWHNCVkeHUh?=
MDA-MB-231 NUjob2tYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTRwN{KxNVUh|ryP NWS0WIRwW0GQR1XS
RKO NGnxfnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;zTGlEPTB;ND63NlgyPyEQvF2= NYTFbHdwW0GQR1XS
COR-L23 NHPwUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXsUHIzUUN3ME20Mlc1OjV4IN88US=> MWfTRW5ITVJ?
DJM-1 M4LHbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XL[2lEPTB;ND63PVczQSEQvF2= M3;nc3NCVkeHUh?=
D-423MG NEDUfWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mwTmlEPTB;ND64NFgxOyEQvF2= NYXQb5NxW0GQR1XS
DMS-114 NGHy[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DRSmlEPTB;ND64NVM5PiEQvF2= NVHDcWV1W0GQR1XS
MHH-ES-1 M2\4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn4TWM2OD12LkiyOVA1KM7:TR?= MWnTRW5ITVJ?
CAL-51 M1j5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTRwOE[4OFMh|ryP NVPsZ29pW0GQR1XS
SW626 MnnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TVZmlEPTB;ND64PVY6PyEQvF2= M1Hi[nNCVkeHUh?=
COLO-824 M4rLZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorCTWM2OD12LkmwOFA5KM7:TR?= NYT6[pJDW0GQR1XS
NCI-H1437 NILPcXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HEUWlEPTB;ND65Nlk{KM7:TR?= MoruV2FPT0WU
CAL-39 M3jvNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljCTWM2OD12LkmzPVg5KM7:TR?= NG\VWZZUSU6JRWK=
PC-3 NHrsVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLkfYRtUUN3ME20Mlk1PjR6IN88US=> M1\y[nNCVkeHUh?=
A101D MkLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTRwOU[4OlUh|ryP NFzGPFdUSU6JRWK=
ES1 NHeyeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjq[GNHUUN3ME21MlAxOTNizszN M4m0OnNCVkeHUh?=
TE-1 NEXvUFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjscoVkUUN3ME21MlA{PjZ4IN88US=> MYXTRW5ITVJ?
KP-N-YN MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTPTWM2OD13LkC1Olch|ryP MVnTRW5ITVJ?
EFO-27 NXLkSY5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTVwME[zNlkh|ryP MVHTRW5ITVJ?
BT-549 NW\jeoxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrhT|hKSzVyPUWuNFc4OzZizszN MlH6V2FPT0WU
HLE Ml2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DjZmlEPTB;NT6xNVc{PCEQvF2= MXzTRW5ITVJ?
SW982 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrMTWM2OD13LkGzN|c1KM7:TR?= M2rXdXNCVkeHUh?=
SCC-25 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjkTWM2OD13LkG5NFQ3KM7:TR?= M2DDbnNCVkeHUh?=
SK-MEL-28 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\4TWM2OD13LkKwN|E{KM7:TR?= NFK3cHNUSU6JRWK=
CaR-1 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTVwMkC3NlYh|ryP M{HuXnNCVkeHUh?=
MLMA MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXzTWM2OD13LkKzOFM3KM7:TR?= NW\jeFJnW0GQR1XS
VM-CUB-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LaTmlEPTB;NT6yN|Q{QSEQvF2= MnPzV2FPT0WU
KNS-42 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HhT2lEPTB;NT6yOlE3KM7:TR?= Mn;aV2FPT0WU
TK10 M3XHWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHqT4dKSzVyPUWuN|YxQDZizszN NGiyVm9USU6JRWK=
MEG-01 MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfYTWM2OD13LkO2Nlc1KM7:TR?= Mm\TV2FPT0WU
DEL MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G1T2lEPTB;NT6zPVAzOyEQvF2= NGDlNIpUSU6JRWK=
SJRH30 M17Re2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrqTWM2OD13LkO5NlE{KM7:TR?= MXLTRW5ITVJ?
SK-PN-DW NXnne5U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXGTWM2OD13LkSzOVg6KM7:TR?= M3\POnNCVkeHUh?=
TE-10 M{HWb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXDWG1KSzVyPUWuOFQ5QTNizszN M4HCOHNCVkeHUh?=
KNS-81-FD MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj4e5gyUUN3ME21MlUxODl{IN88US=> NGH6OYJUSU6JRWK=
BHY NYLafHlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHexOI9KSzVyPUWuOVExPyEQvF2= MkfSV2FPT0WU
KYSE-270 Mkm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3TbXlNUUN3ME21MlU{PTN4IN88US=> NGT1W|NUSU6JRWK=
NCI-H650 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHxRVFKSzVyPUWuOVcyOTRizszN NH\wWXNUSU6JRWK=
L-363 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XxRmlEPTB;NT62PVQ4PiEQvF2= MUPTRW5ITVJ?
TCCSUP M2LJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTVwN{G3O|gh|ryP NX;EOVlsW0GQR1XS
SCH NE[xVZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfv[|lyUUN3ME21Mlc1PzZ5IN88US=> M3SwOHNCVkeHUh?=
HTC-C3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrRTWM2OD13Lke3OlQ1KM7:TR?= NUHZNpJzW0GQR1XS
J-RT3-T3-5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\STWM2OD13LkiwO|k1KM7:TR?= MVPTRW5ITVJ?
Hs-578-T MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTVwOEO2NFch|ryP NILwZodUSU6JRWK=
M14 NIrlPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DZUWlEPTB;NT64OlczPiEQvF2= MUTTRW5ITVJ?
HT-144 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rMbGlEPTB;NT64Olg{OiEQvF2= NYDqUo96W0GQR1XS
CAL-54 NGfrOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTVwOUOzNVQh|ryP MWXTRW5ITVJ?
T47D NXrvT|hiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfp[VdKSzVyPUWuPVYyOiEQvF2= NYP2TJhsW0GQR1XS
GB-1 NWrMOGFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTZwMEKwOlgh|ryP NIXx[llUSU6JRWK=
HSC-2 NWnXT5BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLGSYd5UUN3ME22MlEzOzV|IN88US=> NV;qZ|dMW0GQR1XS
SiHa M1vDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4izSGlEPTB;Nj6xOFA6PyEQvF2= NX\rUopJW0GQR1XS
OMC-1 Mnn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTZwM{W0OFEh|ryP MofvV2FPT0WU
HGC-27 NYDtO5pZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe5SndlUUN3ME22MlM2Pzh4IN88US=> NVfGZ2JlW0GQR1XS
FTC-133 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVriU4hsUUN3ME22MlQ3PTVzIN88US=> NWm1O4IyW0GQR1XS
KS-1 Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPXbZBtUUN3ME22MlUzOTR5IN88US=> M{jqWnNCVkeHUh?=
HT-1080 M3nGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny3TWM2OD14LkW0NFQzKM7:TR?= NIH6SlJUSU6JRWK=
SKG-IIIa NYnmUZBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj1TWM2OD14LkW2NlY{KM7:TR?= M163NHNCVkeHUh?=
OCUB-M M2jlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1joc2lEPTB;Nj62NFc4KM7:TR?= M37FZnNCVkeHUh?=
MDA-MB-175-VII M2OwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTZwNkKwPUDPxE1? M4LEWHNCVkeHUh?=
BB30-HNC M3;Kd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTZwNke0OFQh|ryP MV;TRW5ITVJ?
D-542MG MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zOTGlEPTB;Nj63N|A6KM7:TR?= NEGze5pUSU6JRWK=
NCI-H2405 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj0OGZKSzVyPU[uO|Q5PTVizszN M{KwW3NCVkeHUh?=
SW1573 Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInvNZZKSzVyPU[uO|g{OTlizszN M320VHNCVkeHUh?=
NCI-SNU-1 NF64eIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;yRWlEPTB;Nj63PVAzOiEQvF2= M4jMfXNCVkeHUh?=
RT-112 MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPqR25KSzVyPU[uO|k1PjNizszN NWTve2w3W0GQR1XS
COR-L88 NWLQSYxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi5TWM2OD14Lke5O|kyKM7:TR?= NUL2blNYW0GQR1XS
SCC-9 M3P0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDCPI5KSzVyPU[uPFI2PSEQvF2= NFPWSZVUSU6JRWK=
U-87-MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXtRYdHUUN3ME22Mlg{QDJ4IN88US=> M1[0TXNCVkeHUh?=
Detroit562 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTZwOEW5PVEh|ryP NF3vcpRUSU6JRWK=
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OE33 NES0O45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HC[2lEPTB;M{CuNVM1OiEQvF2= MWHTRW5ITVJ?
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NCI-H1755 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPWOXFKSzVyPUOzMlgyOSEQvF2= M{\aRXNCVkeHUh?=
Mo-T MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTN|Lki1PVMh|ryP MVTTRW5ITVJ?
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RCC10RGB Mn\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDEZXVKSzVyPUOzMlk1OzNizszN MlHEV2FPT0WU
COLO-680N NH3neFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTN2LkGzPVch|ryP MkXxV2FPT0WU
KURAMOCHI NYrmeZpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jWdGlEPTB;M{SuOlQzPSEQvF2= NUjxZYZnW0GQR1XS
NCI-H661 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\oUZlKSzVyPUO0Mlg1PDhizszN NWrTVlA6W0GQR1XS
YAPC M3zZUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O1[GlEPTB;M{WuPVU{OyEQvF2= M3\P[3NCVkeHUh?=
NCI-H526 M1PzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:wWmlKSzVyPUO3MlI4PzJizszN NIK0eFBUSU6JRWK=
A498 NG[4TGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjG[GdKSzVyPUO4MlA6PTRizszN MYfTRW5ITVJ?
VMRC-RCZ MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfxVWdGUUN3ME2zPU4xODV2IN88US=> M3qyU3NCVkeHUh?=
HCT-116 NH;VdG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOzUndKSzVyPUO5MlA2QCEQvF2= M1W5NnNCVkeHUh?=
COLO-320-HSR NHrVWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHKSWVTUUN3ME20NE4xPDFizszN MW\TRW5ITVJ?
OAW-42 M{Lwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HDcWlEPTB;NECuNFU1OiEQvF2= MkLTV2FPT0WU
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CP50-MEL-B MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PIbGlEPTB;NEGuNFc6PyEQvF2= NFf5OWlUSU6JRWK=
RMG-I NH\QeGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTR{LkS5NlEh|ryP NV[xVZhbW0GQR1XS
D-336MG NF3JfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTR|LkGxOVIh|ryP NIfJTZVUSU6JRWK=
SHP-77 NIXSUo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3MTWM2OD12Mz6xPFI5KM7:TR?= NWnvPYZLW0GQR1XS
SW872 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFKwUlZKSzVyPUSzMlIyOjNizszN MnPlV2FPT0WU
DBTRG-05MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTR2Lk[5PVYh|ryP NYG4fG56W0GQR1XS
COLO-678 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLmTWM2OD12NT63NFMzKM7:TR?= NGG2[4FUSU6JRWK=
EGI-1 M1jKd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjXTFRKSzVyPUS3MlE5OzNizszN NELHS|dUSU6JRWK=
KYSE-70 Mmq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHZPXRlUUN3ME20O{44OjJ{IN88US=> M4rpcnNCVkeHUh?=
BALL-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXmfJdKSzVyPUS3MlgzPTRizszN MVHTRW5ITVJ?
MDA-MB-361 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT5NXRxUUN3ME20PE4xPDZizszN NEjRVldUSU6JRWK=
NCI-H1838 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTR6LkO0OVgh|ryP MYPTRW5ITVJ?
NCI-H1573 NYfreWtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR6Lk[3PFUh|ryP NVnyOlV3W0GQR1XS
HCC1395 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLPfHRKSzVyPUS4Mlk6OiEQvF2= NGnlOoNUSU6JRWK=
NCI-H2291 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDrPFBKSzVyPUS5MlU6QDhizszN MmHMV2FPT0WU
RH-18 MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPTeZRKSzVyPUWwMlA5QDRizszN MkHMV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 78 mg/mL (199.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 391.42
Formula

C19H23F2N5O2

CAS No. 501437-28-1
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    BI-D1870 (catalog No.S2843) is found as a racemic mixture?

  • Answer:

    Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID