BI-D1870

Catalog No.S2843

Molecular Weight(MW): 391.42

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Cited by 7 Publications

Neurourol Urodyn, 2019, 38(6):1504-1516

PubMed: 31033016 ( click the link to review the publication )

Mol Cancer Ther, 2017, 10.1158/1535-7163.MCT-17-0114

PubMed: 28566436 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(5):793-804

PubMed: 28167505 ( click the link to review the publication )

J Biol Chem, 2017, 292(28):11804-11814

PubMed: 28559278 ( click the link to review the publication )

Sci Rep, 2016, 6:36134

PubMed: 27786305 ( click the link to review the publication )

J Biol Chem, 2015, 289(46):31950-9

PubMed: 25278019 ( click the link to review the publication )

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602 ( click the link to review the publication )

4 Customer Reviews

Expressions of active forms of all p90RSK isoforms were assessed by immunoblotting in Control vs. GR cells following treatment with increasing concentrations of BI-D1870 for 24 hours. Actin was included as a loading control.

Mol Cancer Ther, 2017, 16(5):793-804. BI-D1870 purchased from Selleck.

(g) Changes of UBE2R1 expression in cells treated with an RSK inhibitor, BI-D1870, for 6 h.

Sci Rep, 2016, 6:36134.. BI-D1870 purchased from Selleck.
HeLa cells were serum starved for 24 h, and then were treated with MK2206 (1 μM), rapamycin (Rapa; 100 nM), PP242 (1 μM), BEZ235 (0.5 μM), U0126 (U0; 15 μM), BI-D1870 (BI; 10 μM), GNE-652 (1 μM), AZD1208 (3 μM), and the indicated inhibitor combinations for 3 h before insulin (1 g/ml) was added for an additional 30 min. Cell lysates were analyzed by immunoblot assays using the indicated antibodies.

Mol Cell Biol, 2014, 34(13): 2517-32. BI-D1870 purchased from Selleck.

Serum-starved N41/OX1R cells were treated with 50 nM orexin-A for 1 h with or without 1 or 10 μM BI-D1870. Phosphorylation of S6K and S6 as well as MEK1/2, RSK, and Erk1/2 were evaluated by Western blotting.

J Biol Chem, 2014, 289(46): 31950-9. BI-D1870 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description

Targets

RSK4 ^[1] (Cell-free assay)	RSK3 ^[1] (Cell-free assay)	RSK2 ^[1] (Cell-free assay)	RSK1 ^[1] (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

In vitro

BI-D1870 inhibits RSK1, RSK2, RSK3 and RSK4 with an IC50 of 10–30 nM, but does not significantly inhibit ten other AGC kinase members and over 40 other protein kinases tested at 100-fold higher concentrations. BI-D1870 is cell permeant and prevents the RSK-mediated phorbol ester- and EGF -induced phosphorylation of glycogen synthase kinase-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells. BI-D1870 does not affect the agonist-triggered phosphorylation of substrates for six other AGC kinases. Moreover, BI-D1870 does not suppress the phorbol ester- or EGF-induced phosphorylation of CREB. ^[1]

Cell Data

Cell Lines	Assay Type	Activity Description	PMID
EW-3	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmfnTWM2OD1yLkCzOVgh\|ryP	M4j2[XNCVkeHUh?=
H9	M4fmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1PNTWlEPTB;MD6wOlAyQSEQvF2=	MYTTRW5ITVJ?
KARPAS-45	NXHCWHQxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml:zTWM2OD1yLkG2OVI2KM7:TR?=	NXPCVVJMW0GQR1XS
NCI-H720	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml;UTWM2OD1yLkG3NVk1KM7:TR?=	MUHTRW5ITVJ?
CTV-1	MkfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoLlTWM2OD1yLkS3PFczKM7:TR?=	NFza[nJUSU6JRWK=
DU-4475	Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUfJTnU1UUN3ME2wMlUxPDF5IN88US=>	MmCzV2FPT0WU
A172	NXvJRZdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXrJR\|UxRTBwNUG3NFUh\|ryP	MWLTRW5ITVJ?
EW-18	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGTrWFlKSzVyPUCuOlIzOTFizszN	M1vSb3NCVkeHUh?=
KU812	M3HtOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3zSOGlEPTB;MD62NlYzOyEQvF2=	NF\qOY1USU6JRWK=
KP-N-YS	MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn\STWM2OD1yLk[4NlI{KM7:TR?=	NEXFNotUSU6JRWK=
SBC-1	M4LQ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorzTWM2OD1yLk[5OVI1KM7:TR?=	M2n2VXNCVkeHUh?=
ECC10	NVW4WlJQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV3JR\|UxRTBwN{CwPVQh\|ryP	M{DyZ3NCVkeHUh?=
GAMG	NUnOVVNST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFXVTHhKSzVyPUCuO\|Q4OTdizszN	MWnTRW5ITVJ?
NCI-H209	Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NUPHeYdxUUN3ME2wMlc3QDJizszN	MX;TRW5ITVJ?
MC-IXC	NFP1[4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFS0[YVKSzVyPUCuO\|k2QDlizszN	Ml7PV2FPT0WU
HSC-3	NIPDcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2KxfGlEPTB;MD64NVc3QSEQvF2=	NGfBfYdUSU6JRWK=
IST-SL1	MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1raSWlEPTB;MD64OFU4PCEQvF2=	M3HUOHNCVkeHUh?=
LU-139	NIXCbZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUHzb5BYUUN3ME2wMlg1QTV6IN88US=>	NF;Gb4RUSU6JRWK=
ML-2	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVjuXYdDUUN3ME2wMlg2PTd3IN88US=>	MWPTRW5ITVJ?
CAL-62	M2KzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYPJR\|UxRTBwOEixOVIh\|ryP	M2nNNXNCVkeHUh?=
HL-60	NX;tO\|Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFTxPZNKSzVyPUCuPFg{PjJizszN	M1nqXHNCVkeHUh?=
KY821	M4POOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVf5eJRSUUN3ME2wMlg5QDF{IN88US=>	M1nRVnNCVkeHUh?=
ES7	MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFXLNFVKSzVyPUCuPVE3ODdizszN	M3PyOnNCVkeHUh?=
MV-4-11	NGWxTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\OXGlEPTB;MD65O\|g6PyEQvF2=	MkXYV2FPT0WU
Daoy	NHnpc\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NY\ZPFJIUUN3ME2wMlk5PzZ5IN88US=>	NFuyZVdUSU6JRWK=
EoL-1-cell	NF[3bmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HFPWlEPTB;MT6wNVg4QCEQvF2=	NFXibGtUSU6JRWK=
TGW	MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXH2e3RYUUN3ME2xMlA2OTJ2IN88US=>	Mmj4V2FPT0WU
LAMA-84	MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVfBVHM4UUN3ME2xMlEzPzl2IN88US=>	MmXoV2FPT0WU
KOSC-2	NYnZfZZtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3TheWlEPTB;MT6xN\|M5PSEQvF2=	M4D1fHNCVkeHUh?=
A549	NXP3[XNlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mlf4TWM2OD1zLkOwPVU2KM7:TR?=	NVrKOYw4W0GQR1XS
CTB-1	NVHjTYZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NGjBW3VKSzVyPUGuOFQ3PzlizszN	Ml\qV2FPT0WU
NCI-H292	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH:zR2VKSzVyPUGuOFYxPjlizszN	NVm5TJI{W0GQR1XS
LoVo	M4Dsb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorFTWM2OD1zLkS2O\|U2KM7:TR?=	MXTTRW5ITVJ?
BFTC-905	NHL0W2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MojUTWM2OD1zLkW2N\|MzKM7:TR?=	NX3oU4tmW0GQR1XS
BE-13	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NIjKendKSzVyPUGuOVg4ODlizszN	Ml3mV2FPT0WU
KE-37	NH63PWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NITFdGhKSzVyPUGuOVk1PzhizszN	NVfHdJRJW0GQR1XS
HN	NWXWWIlwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NH3GZ2lKSzVyPUGuOlE{PjhizszN	MkjWV2FPT0WU
A3-KAW	NUfrXoxxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYrSbpg2UUN3ME2xMlYzQDN2IN88US=>	MWDTRW5ITVJ?
NEC8	NFfXelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1y1UWlEPTB;MT63NFEyPSEQvF2=	MYjTRW5ITVJ?
Ramos-2G6-4C10	NGXm[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWnJR\|UxRTFwN{C0OFQh\|ryP	NYT1V5o6W0GQR1XS
NB10	M2HzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlXBTWM2OD1zLke3OlMh\|ryP	Ml7YV2FPT0WU
NBsusSR	M1rXUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4jF[2lEPTB;MT64Nlk3OSEQvF2=	MnHvV2FPT0WU
ES4	M3HJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHRc2JCUUN3ME2xMlg2OTR\|IN88US=>	NWnUR4ZLW0GQR1XS
ES8	Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NETVb\|hKSzVyPUGuPFc4OjRizszN	MnnTV2FPT0WU
CHL-1	NWHqfJZCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXrvRotiUUN3ME2xMlk2Pzl{IN88US=>	NIfSUWNUSU6JRWK=
NCI-H2029	NVOzeJNUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIToXYRKSzVyPUGuPVczPDFizszN	MWnTRW5ITVJ?
YKG-1	MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkD4TWM2OD1zLkm4OFMzKM7:TR?=	M3HoNnNCVkeHUh?=
BV-173	M3HRfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoDKTWM2OD1zLkm4OlY3KM7:TR?=	NGn5NZFUSU6JRWK=
697	MmXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXPJR\|UxRTJwMEKyNlgh\|ryP	MWTTRW5ITVJ?
SK-NEP-1	M2HwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYD0dnkxUUN3ME2yMlA1PCEQvF2=	MVHTRW5ITVJ?
LOXIMVI	M2Hv[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NF3nVG1KSzVyPUKuNFQ1OzRizszN	M1zMfnNCVkeHUh?=
QIMR-WIL	NF;yW25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVraOYU2UUN3ME2yMlA4QDR7IN88US=>	MYjTRW5ITVJ?
DU-145	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUDJR\|UxRTJwMUGwOVYh\|ryP	NHr4eVdUSU6JRWK=
NB14	M{jmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEXNZ49KSzVyPUKuNVE{OjFizszN	NF\1[ndUSU6JRWK=
G-361	NYnQVYRRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFu5bm9KSzVyPUKuNVIzOSEQvF2=	MXjTRW5ITVJ?
BPH-1	NFy5W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MonFTWM2OD1{LkGyPVU4KM7:TR?=	M{\rRXNCVkeHUh?=
KYSE-150	NF7MTm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIjTXWFKSzVyPUKuNVUzOzRizszN	NEXpOmxUSU6JRWK=
HMV-II	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYX3dGpCUUN3ME2yMlE3PjN\|IN88US=>	MVXTRW5ITVJ?
TE-9	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXLJR\|UxRTJwMUezO\|Yh\|ryP	NGHhTW1USU6JRWK=
8-MG-BA	MmrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHftco9KSzVyPUKuNlM1PjFizszN	M{T0[3NCVkeHUh?=
ES5	MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn;YTWM2OD1{LkKzOlM{KM7:TR?=	MXfTRW5ITVJ?
D-283MED	MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlLFTWM2OD1{LkKzOlk2KM7:TR?=	MXXTRW5ITVJ?
SK-N-AS	M{ntemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TacWlEPTB;Mj6yPVA2QSEQvF2=	MlrnV2FPT0WU
SW1710	NXLEb4hPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTJwM{C2OlEh\|ryP	NXzEXphqW0GQR1XS
GCT	M1jQd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MknQTWM2OD1{LkOxN\|U5KM7:TR?=	NVL1[okyW0GQR1XS
AGS	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGG1d41KSzVyPUKuN\|Q1ODRizszN	MmDCV2FPT0WU
HuO9	NG\SW\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF[yVXNKSzVyPUKuN\|Y5OjRizszN	NIWzZYpUSU6JRWK=
MN-60	MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWDJR\|UxRTJwNES4PFMh\|ryP	NVzHXWZwW0GQR1XS
NB6	NXzJblQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFHpZodKSzVyPUKuOFU4PzlizszN	MXfTRW5ITVJ?
NCI-H1395	NIL4eXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWHKT3dvUUN3ME2yMlQ4OTJzIN88US=>	NUHpdoFVW0GQR1XS
H4	Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlTDTWM2OD1{LkS4N\|k{KM7:TR?=	NITXS\|lUSU6JRWK=
HT-3	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXPh[o9QUUN3ME2yMlUyODJ2IN88US=>	MlLZV2FPT0WU
P12-ICHIKAWA	NGOxVHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mnz2TWM2OD1{LkWyOVU6KM7:TR?=	NUjmXoNxW0GQR1XS
COLO-800	NGraXmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTJwNUSxOlYh\|ryP	NIfyW3JUSU6JRWK=
DB	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTJwNUWwNVMh\|ryP	MXXTRW5ITVJ?
LCLC-97TM1	NUW5XmM2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mle3TWM2OD1{Lk[wNFI5KM7:TR?=	NYj5fWhYW0GQR1XS
Ca9-22	M{TwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MorCTWM2OD1{Lk[1PVM{KM7:TR?=	NILmOZBUSU6JRWK=
Becker	NY\WRVJrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVrJR\|UxRTJwNk[wO\|gh\|ryP	MYTTRW5ITVJ?
ACN	M1\ldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYLBbVJCUUN3ME2yMlY3PzlizszN	MWrTRW5ITVJ?
SJSA-1	M3S2fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHTydlBKSzVyPUKuOlY5PyEQvF2=	M1y1THNCVkeHUh?=
NCI-H1048	NXLEeW04T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmD4TWM2OD1{Lk[4N\|IyKM7:TR?=	MWLTRW5ITVJ?
HEL	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUjJR\|UxRTJwN{CyOVQh\|ryP	NFHE[JdUSU6JRWK=
NCI-H69	NHTofWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnXpTWM2OD1{LkexOlAyKM7:TR?=	M4PpdnNCVkeHUh?=
639-V	M{XlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIiyXI9KSzVyPUKuO\|E4ODNizszN	NWTuemUxW0GQR1XS
U251	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Ml\2TWM2OD1{LkezNFMzKM7:TR?=	NWjKO5h2W0GQR1XS
NCI-H1792	NIK4SGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkS2TWM2OD1{LkezO\|M5KM7:TR?=	NX;Yc3VPW0GQR1XS
EW-1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWHsWHZiUUN3ME2yMlc2OzJ6IN88US=>	M2npTXNCVkeHUh?=
ME-180	NULnXY4{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHzUJh[UUN3ME2yMlc4PzN4IN88US=>	NHzzUpFUSU6JRWK=
HH	NE\oc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVzJR\|UxRTJwOECwNFEh\|ryP	MVfTRW5ITVJ?
SW954	Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmLwTWM2OD1{Lki1PFMh\|ryP	M4THcnNCVkeHUh?=
SF268	M3XjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3mwN2lEPTB;Mj64O\|IzPSEQvF2=	NXfZTWZ4W0GQR1XS
D-566MG	NFXRW2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1HLfmlEPTB;Mj65NVI6PSEQvF2=	MkC4V2FPT0WU
EM-2	NFy4eWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3zl[mlEPTB;Mj65NlE6OyEQvF2=	M3fve3NCVkeHUh?=
NCI-H1299	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXTubGRUUUN3ME2yMlk{PzN4IN88US=>	NW\2d3U6W0GQR1XS
PSN1	NX;LVlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXLjd5c3UUN3ME2zMlA2Pzh4IN88US=>	M4rs[XNCVkeHUh?=
JVM-3	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYHJR\|UxRTNwME[3OVYh\|ryP	Mm\sV2FPT0WU
D-502MG	NWjYdYp6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFzJTplKSzVyPUOuNFcxOTlizszN	MX3TRW5ITVJ?
SCC-4	M{PaeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHLLRVNKSzVyPUOuNFkzPzZizszN	M2PUUnNCVkeHUh?=
GMS-10	MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYLJR\|UxRTNwMEmzPFgh\|ryP	NILGO4VUSU6JRWK=
A427	M2rwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NVLCZ\|VTUUN3ME2zMlExQDd\|IN88US=>	MmrQV2FPT0WU
NH-12	NXHYPVE3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWTJR\|UxRTNwMUG0OVYh\|ryP	M3f0TnNCVkeHUh?=
KM12	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHLJ[ZpKSzVyPUOuNVIzPzNizszN	NFPTXmRUSU6JRWK=
GI-1	MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVzJR\|UxRTNwMUWyOVUh\|ryP	NYLDUFN3W0GQR1XS
TE-8	MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnXuTWM2OD1\|LkG5NlMyKM7:TR?=	M2nyOnNCVkeHUh?=
MKN1	Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MlrrTWM2OD1\|LkKwPFc2KM7:TR?=	NIjJ[\|dUSU6JRWK=
NCI-H810	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHmTWM2OD1\|LkKyNVU2KM7:TR?=	NWO0XGdyW0GQR1XS
GOTO	NXTab3E3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUjJR\|UxRTNwMkiwNFQh\|ryP	MoT2V2FPT0WU
T98G	MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mom3TWM2OD1\|LkK4NlE3KM7:TR?=	MWrTRW5ITVJ?
HD-MY-Z	NH[1VY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHfHXYtKSzVyPUOuN\|Y2PDJizszN	MYXTRW5ITVJ?
SNU-C2B	NF23TVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1rjVWlEPTB;Mz6zPVA6PyEQvF2=	MoLwV2FPT0WU
MOLT-4	NWHZd3Z{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFLycpVKSzVyPUOuN\|kxQThizszN	MoLvV2FPT0WU
RPMI-7951	MlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYXJR\|UxRTNwM{m3N{DPxE1?	NHHzSYJUSU6JRWK=
EW-11	MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEL0S2lKSzVyPUOuOFEzOjRizszN	Mnf3V2FPT0WU
RD	Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYPydGMxUUN3ME2zMlQ{OTN{IN88US=>	M3v5SnNCVkeHUh?=
SW48	NH[5Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2rvXWlEPTB;Mz60N\|M2QCEQvF2=	M2fDW3NCVkeHUh?=
BB65-RCC	NFzuSpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1nKTGlEPTB;Mz60OVM6PiEQvF2=	NFjGfIRUSU6JRWK=
Ca-Ski	NGXUTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEjleWhKSzVyPUOuOFc2OTRizszN	NEHyOphUSU6JRWK=
CHP-134	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlHITWM2OD1\|LkS4O\|U5KM7:TR?=	NV7Xbm1HW0GQR1XS
CAL-33	NELp[\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MVXJR\|UxRTNwNUOzOlIh\|ryP	NIPIbGFUSU6JRWK=
TYK-nu	M3PZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHO1NJJKSzVyPUOuOVM3PzZizszN	M2TQPXNCVkeHUh?=
LB831-BLC	NFW1d5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVjnOIlFUUN3ME2zMlU1ODF4IN88US=>	MoXRV2FPT0WU
KU-19-19	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTNwNkCzNFQh\|ryP	M3fXd3NCVkeHUh?=
KG-1	MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoXOTWM2OD1\|Lk[xNVA3KM7:TR?=	NYPxcHV4W0GQR1XS
COLO-829	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH71VHVKSzVyPUOuOlY3OThizszN	MkT1V2FPT0WU
HUTU-80	M3TkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NH\3WoNKSzVyPUOuOlY3OjFizszN	Ml7VV2FPT0WU
NCI-H446	M{fCfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIH5VnhKSzVyPUOuOlg{PCEQvF2=	NHz6eoNUSU6JRWK=
LB2241-RCC	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{nxRWlEPTB;Mz62PFYzPSEQvF2=	MkHMV2FPT0WU
JEG-3	NWLiRnZiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWrJR\|UxRTNwNkmxPUDPxE1?	NUTxcZlZW0GQR1XS
LNCaP-Clone-FGC	NV;aNZR7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NIDXR\|RKSzVyPUOuO\|AxPDFizszN	MYrTRW5ITVJ?
M059J	NF:zN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4LRSWlEPTB;Mz63NVQ3QCEQvF2=	NFO0cmRUSU6JRWK=
SK-MES-1	NX73Um44T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWXJR\|UxRTNwN{OwN{DPxE1?	NXu4emZ1W0GQR1XS
GT3TKB	Mm\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4LVSGlEPTB;Mz63OVYxPCEQvF2=	M4PRPXNCVkeHUh?=
DOK	MknxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVHDNHdvUUN3ME2zMlc3PTJ4IN88US=>	NYrWXoJYW0GQR1XS
HO-1-N-1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXfJR\|UxRTNwN{m4NFEh\|ryP	MWjTRW5ITVJ?
MZ1-PC	NVGwR2ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofoTWM2OD1\|LkiyPFg{KM7:TR?=	MXPTRW5ITVJ?
8305C	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXGxSo9[UUN3ME2zMlg5QTR\|IN88US=>	M3jmPXNCVkeHUh?=
CGTH-W-1	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYPzeVRJUUN3ME2zMlk{PTB2IN88US=>	MnrLV2FPT0WU
LU-134-A	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnvzTWM2OD1\|Lkm1OFIzKM7:TR?=	MmPwV2FPT0WU
C32	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGXTT2JKSzVyPUOuPVY2QDFizszN	NVvnfmNOW0GQR1XS
MOLT-13	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXnpT2VWUUN3ME2zMlk3QDV4IN88US=>	MmDZV2FPT0WU
A375	NGjJVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NXmyXIEyUUN3ME20MlA2OTZ{IN88US=>	NYP2RpBJW0GQR1XS
CAL-12T	NFK5WnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH73ZlBKSzVyPUSuNFU4QTVizszN	MkjUV2FPT0WU
IGR-1	NXX5bGcxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVPN[JU3UUN3ME20MlExOjd2IN88US=>	NUjKeYJqW0GQR1XS
LB1047-RCC	M1vyd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGPwbnlKSzVyPUSuNVA1PDFizszN	M4HidnNCVkeHUh?=
BHT-101	Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MX\JR\|UxRTRwMUC2PFMh\|ryP	M1vWOXNCVkeHUh?=
A431	NV\Ce2FRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYHlN4VUUUN3ME20MlE1ODhzIN88US=>	Mof1V2FPT0WU
EPLC-272H	M1vYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmjZTWM2OD12LkG3OVk3KM7:TR?=	MkGxV2FPT0WU
HT-1376	NF\wd5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIjhSJNKSzVyPUSuNlMxPTlizszN	M4fBUHNCVkeHUh?=
HCC1954	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NYC5VWR3UUN3ME20MlI2PzR4IN88US=>	MYTTRW5ITVJ?
KYSE-510	M3e3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4fJZ2lEPTB;ND6yOlA6KM7:TR?=	M33MdXNCVkeHUh?=
PANC-03-27	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MonHTWM2OD12LkOwNFg{KM7:TR?=	M33ibHNCVkeHUh?=
MDA-MB-157	M{m1bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUTJR\|UxRTRwM{C2OVYh\|ryP	NH;aOotUSU6JRWK=
HOP-62	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGjYfplKSzVyPUSuN\|A5PTZizszN	MV\TRW5ITVJ?
ETK-1	M4T4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3;2bmlEPTB;ND6zOlIxOyEQvF2=	M{XzPXNCVkeHUh?=
MIA-PaCa-2	NHWwSphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MXnJR\|UxRTRwM{[yNlch\|ryP	M1rBc3NCVkeHUh?=
MHH-PREB-1	M3u1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlXLTWM2OD12LkO5O\|c{KM7:TR?=	M1r4b3NCVkeHUh?=
LXF-289	MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MY\JR\|UxRTRwNECyNFIh\|ryP	MkXZV2FPT0WU
ATN-1	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoTtTWM2OD12LkSyN\|QyKM7:TR?=	MV\TRW5ITVJ?
8505C	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYrJR\|UxRTRwNEW4NlUh\|ryP	NYfkOnlGW0GQR1XS
HOS	NXfuW24yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M3\OdGlEPTB;ND60OlQ2OyEQvF2=	MlPXV2FPT0WU
U-266	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1XyXmlEPTB;ND62NVA{OiEQvF2=	MlPCV2FPT0WU
5637	NUDHZXNsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1TPPWlEPTB;ND62NVQ1PCEQvF2=	NIjN[mZUSU6JRWK=
GCIY	NGC3VHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MWLJR\|UxRTRwN{GwNVUh\|ryP	NV3HXoVuW0GQR1XS
MDA-MB-231	NID4[ZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mn7iTWM2OD12LkeyNVE2KM7:TR?=	MVrTRW5ITVJ?
RKO	MlzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MnfVTWM2OD12LkeyPFE4KM7:TR?=	NYS2WI5EW0GQR1XS
COR-L23	M1ewfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFrPO2pKSzVyPUSuO\|QzPTZizszN	MkmzV2FPT0WU
DJM-1	NXH2XXJxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2XJN2lEPTB;ND63PVczQSEQvF2=	NEi4TI1USU6JRWK=
D-423MG	NVi5dlRRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MVzJR\|UxRTRwOEC4NFMh\|ryP	NE\3OZJUSU6JRWK=
DMS-114	NWC1dlBIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn;wTWM2OD12LkixN\|g3KM7:TR?=	NFrzR4ZUSU6JRWK=
MHH-ES-1	M1PuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXj5d45JUUN3ME20MlgzPTB2IN88US=>	Mn;1V2FPT0WU
CAL-51	Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NISy[5dKSzVyPUSuPFY5PDNizszN	NHu2[\|BUSU6JRWK=
SW626	NVexeYlLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYfzRpRVUUN3ME20Mlg6Pjl5IN88US=>	MnrTV2FPT0WU
COLO-824	MkHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4TjemlEPTB;ND65NFQxQCEQvF2=	NI\TPXZUSU6JRWK=
NCI-H1437	MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXLJR\|UxRTRwOUK5N{DPxE1?	MXzTRW5ITVJ?
CAL-39	MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MVPJR\|UxRTRwOUO5PFgh\|ryP	NXvxRVJ3W0GQR1XS
PC-3	NXfLd4lGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWXoS5B{UUN3ME20Mlk1PjR6IN88US=>	MlzDV2FPT0WU
A101D	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV\JR\|UxRTRwOU[4OlUh\|ryP	M2C2cXNCVkeHUh?=
ES1	M3fw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NI\vSYxKSzVyPUWuNFAyOyEQvF2=	NWX1b2VWW0GQR1XS
TE-1	NWTZZlNIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NFzWXmdKSzVyPUWuNFM3PjZizszN	Mke0V2FPT0WU
KP-N-YN	NYf6WGk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYDDZoV5UUN3ME21MlA2PjdizszN	M{faNHNCVkeHUh?=
EFO-27	Ml;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4fUU2lEPTB;NT6wOlMzQSEQvF2=	M2nldHNCVkeHUh?=
BT-549	Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NGrzXINKSzVyPUWuNFc4OzZizszN	NFLVW5pUSU6JRWK=
HLE	M4juVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NYXZSW17UUN3ME21MlEyPzN2IN88US=>	M4LBeXNCVkeHUh?=
SW982	NG[1[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NGLw[XlKSzVyPUWuNVM{PzRizszN	NXzFWnh[W0GQR1XS
SCC-25	M{[xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fke2lEPTB;NT6xPVA1PiEQvF2=	Mn;FV2FPT0WU
SK-MEL-28	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXe1UpdRUUN3ME21MlIxOzF\|IN88US=>	MVTTRW5ITVJ?
CaR-1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MUPJR\|UxRTVwMkC3NlYh\|ryP	NEDRbYhUSU6JRWK=
MLMA	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkfFTWM2OD13LkKzOFM3KM7:TR?=	NH3FWZlUSU6JRWK=
VM-CUB-1	MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWLJR\|UxRTVwMkO0N\|kh\|ryP	Mmq4V2FPT0WU
KNS-42	M2LvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4\weGlEPTB;NT6yOlE3KM7:TR?=	MXLTRW5ITVJ?
TK10	NFryNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MnP3TWM2OD13LkO2NFg3KM7:TR?=	M37RSHNCVkeHUh?=
MEG-01	NXzw[2hZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXTJR\|UxRTVwM{[yO\|Qh\|ryP	NYn2eWZuW0GQR1XS
DEL	M3L6fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4i3NWlEPTB;NT6zPVAzOyEQvF2=	MmjiV2FPT0WU
SJRH30	NUXnNZJPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Ml7UTWM2OD13LkO5NlE{KM7:TR?=	MmjIV2FPT0WU
SK-PN-DW	NVLtNVNTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnO2TWM2OD13LkSzOVg6KM7:TR?=	MlzwV2FPT0WU
TE-10	M3vHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3e2NWlEPTB;NT60OFg6OyEQvF2=	M2jZ[XNCVkeHUh?=
KNS-81-FD	NG[4Tm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Ml6xTWM2OD13LkWwNFkzKM7:TR?=	NFjFdWlUSU6JRWK=
BHY	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXjiXHJzUUN3ME21MlUyODdizszN	NYDlNHdpW0GQR1XS
KYSE-270	MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M{DtbGlEPTB;NT61N\|U{PiEQvF2=	MlHSV2FPT0WU
NCI-H650	NYn6WpNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXLJR\|UxRTVwNUexNVQh\|ryP	M{f4cnNCVkeHUh?=
L-363	Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFHIW45KSzVyPUWuOlk1PzZizszN	M4OxXnNCVkeHUh?=
TCCSUP	M2O4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1XodWlEPTB;NT63NVc4QCEQvF2=	NVzFd4lSW0GQR1XS
SCH	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmjCTWM2OD13Lke0O\|Y4KM7:TR?=	MUTTRW5ITVJ?
HTC-C3	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmmwTWM2OD13Lke3OlQ1KM7:TR?=	M2\4S3NCVkeHUh?=
J-RT3-T3-5	M4HKcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Ml7YTWM2OD13LkiwO\|k1KM7:TR?=	MXHTRW5ITVJ?
Hs-578-T	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1\HeGlEPTB;NT64N\|YxPyEQvF2=	MVfTRW5ITVJ?
M14	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{PGZ2lEPTB;NT64OlczPiEQvF2=	MVHTRW5ITVJ?
HT-144	M1rv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1TKSGlEPTB;NT64Olg{OiEQvF2=	M1zCNnNCVkeHUh?=
CAL-54	NVvVTmp7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX3lXIJtUUN3ME21Mlk{OzF2IN88US=>	M{HqOHNCVkeHUh?=
T47D	NGXRN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M4T0NWlEPTB;NT65OlEzKM7:TR?=	M3XYSHNCVkeHUh?=
GB-1	NYTqPG1rT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWP5SpFPUUN3ME22MlAzODZ6IN88US=>	MWDTRW5ITVJ?
HSC-2	NXj1PHo{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVvMVoJxUUN3ME22MlEzOzV\|IN88US=>	NEPTeIVUSU6JRWK=
SiHa	NFHoUHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3\jNmlEPTB;Nj6xOFA6PyEQvF2=	MnH6V2FPT0WU
OMC-1	NHTpdpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2XyN2lEPTB;Nj6zOVQ1OSEQvF2=	NXXZeJR2W0GQR1XS
HGC-27	NXzhSG5jT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkfUTWM2OD14LkO1O\|g3KM7:TR?=	MVzTRW5ITVJ?
FTC-133	MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3vxTmlEPTB;Nj60OlU2OSEQvF2=	MULTRW5ITVJ?
KS-1	NYP6dopUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MV7JR\|UxRTZwNUKxOFch\|ryP	MXLTRW5ITVJ?
HT-1080	NH7uW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M3vMdmlEPTB;Nj61OFA1OiEQvF2=	M4PzNXNCVkeHUh?=
SKG-IIIa	MlPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2LC[mlEPTB;Nj61OlI3OyEQvF2=	MlO3V2FPT0WU
OCUB-M	NVrnU2k5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NITpVlRKSzVyPU[uOlA4PyEQvF2=	M4K3WnNCVkeHUh?=
MDA-MB-175-VII	MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEL2elBKSzVyPU[uOlIxQSEQvF2=	NGLFN5dUSU6JRWK=
BB30-HNC	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MU\JR\|UxRTZwNke0OFQh\|ryP	M2jFb3NCVkeHUh?=
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NCI-H2405	MoH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mlm0TWM2OD14Lke0PFU2KM7:TR?=	M{nvdnNCVkeHUh?=
SW1573	MlHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmjZTWM2OD14Lke4N\|E6KM7:TR?=	NEK5[VdUSU6JRWK=
NCI-SNU-1	NX7ncIF7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEPmZnJKSzVyPU[uO\|kxOjJizszN	NWfmW211W0GQR1XS
RT-112	NYS3fpdMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4HSPGlEPTB;Nj63PVQ3OyEQvF2=	NH65TWhUSU6JRWK=
COR-L88	NHe3[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NFTLN2xKSzVyPU[uO\|k4QTFizszN	MkHvV2FPT0WU
SCC-9	M4TSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYLJR\|UxRTZwOEK1OUDPxE1?	MYPTRW5ITVJ?
U-87-MG	M4XoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXXFc29MUUN3ME22Mlg{QDJ4IN88US=>	NWfHd2pRW0GQR1XS
Detroit562	M2X2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NX7Be\|ZuUUN3ME22Mlg2QTlzIN88US=>	MWnTRW5ITVJ?
LC-2-ad	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVfJR\|UxRTZwOE[yPVIh\|ryP	Mn2yV2FPT0WU
IGROV-1	M{LIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NGXqO3BKSzVyPU[uPVI2QDNizszN	NEX0T2hUSU6JRWK=
OVCAR-8	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVewNYFkUUN3ME22Mlk1OjJ7IN88US=>	MYXTRW5ITVJ?
SNU-387	NFziUlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoPPTWM2OD14Lkm5OVE3KM7:TR?=	MoPkV2FPT0WU
TGBC1TKB	M1Hacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXu2bmpsUUN3ME23MlE2Ojd5IN88US=>	MV\TRW5ITVJ?
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HEC-1	MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NEL3PJRKSzVyPUeuNlU{QDdizszN	NFjGWVFUSU6JRWK=
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KYSE-520	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MYXJR\|UxRTdwMkmyPUDPxE1?	NWLITHdsW0GQR1XS
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OVCAR-4	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGnQSlNKSzVyPUeuOVUzPiEQvF2=	MULTRW5ITVJ?
KYSE-450	M2TRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NEnUPHpKSzVyPUeuOlM4QTFizszN	MYjTRW5ITVJ?
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CAL-27	NFn0OotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWnSWXZ6UUN3ME24MlEzPzJizszN	MnnZV2FPT0WU
FADU	NE\HU4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NEHlWGFKSzVyPUiuNVc2PDNizszN	Ml32V2FPT0WU
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ACHN	M3eyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkXpTWM2OD16LkKyOVI6KM7:TR?=	MmjkV2FPT0WU
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NCI-H2087	M4D2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M4D0d2lEPTB;OD6zOlE2QCEQvF2=	NGXQfVlUSU6JRWK=
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MEL-JUSO	MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M1GwUWlEPTB;OD62PFY4PSEQvF2=	NFXWWmVUSU6JRWK=
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HuH-7	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkL0TWM2OD16LkezNFEzKM7:TR?=	MXfTRW5ITVJ?
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NCI-H28	MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NESwOZhKSzVyPUiuPFUyQDVizszN	NHL3ZVdUSU6JRWK=
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DMS-273	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVf2VHV{UUN3ME24Mlg6PjJ\|IN88US=>	NUjocWtUW0GQR1XS
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BT-474	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	Mn3WTWM2OD16Lkm4PFczKM7:TR?=	MVPTRW5ITVJ?
TI-73	NELWfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUDxZ5Q4UUN3ME25MlA{PDl4IN88US=>	MWLTRW5ITVJ?
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NB17	MoL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MUDJR\|UxRTlwMUS1N\|Uh\|ryP	MoDGV2FPT0WU
MOLT-16	Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTzTWM2OD17LkG2OlU2KM7:TR?=	M3H3RnNCVkeHUh?=
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MEL-HO	M2qyeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MkHFTWM2OD17LkSwNkDPxE1?	MXXTRW5ITVJ?
HuCCT1	MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWXLUmV6UUN3ME25MlQ4PDB4IN88US=>	NV\qWIxtW0GQR1XS
A704	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXzJR\|UxRTlwNEe3OFUh\|ryP	MmTvV2FPT0WU
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NKM-1	NYi5V\|RuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmjzTWM2OD17LkizPVY1KM7:TR?=	NIqySm9USU6JRWK=
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SF539	MoewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MYHJR\|UxRTFyLkexPFgh\|ryP	MUXTRW5ITVJ?
CAL-120	NEe0ZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUnJR\|UxRTFyLke1PVch\|ryP	NV\odnl1W0GQR1XS
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NCI-H2452	NVm4bJVvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NX\sb\|BTUUN3ME2xNU4{QTJ5IN88US=>	NXf5[JJrW0GQR1XS
NCI-H1648	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWLJR\|UxRTFzLkS2Nlkh\|ryP	MoLOV2FPT0WU
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NCI-H2228	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NVTEdphUUUN3ME2xNU41QTJ6IN88US=>	M1LUV3NCVkeHUh?=
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HCC1806	NYfqTmR5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4WzdmlEPTB;MUGuOlE{PCEQvF2=	NYflPXRLW0GQR1XS
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BB49-HNC	M1nZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUDJR\|UxRTFzLkizO\|Uh\|ryP	M4H1WnNCVkeHUh?=
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NOMO-1	M3zUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXfJR\|UxRTFzLki1PVch\|ryP	MnPyV2FPT0WU
A388	NUPIcGR1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlnFTWM2OD1zMT64PFA5KM7:TR?=	MXvTRW5ITVJ?
Saos-2	MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4jhbWlEPTB;MUKuNlAxOyEQvF2=	MnXUV2FPT0WU
SK-HEP-1	NEnOXW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{\odWlEPTB;MUKuNlYyOyEQvF2=	NEPUd29USU6JRWK=
HCE-4	M{\XeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWfJR\|UxRTF{LkK2PVkh\|ryP	M3jrUnNCVkeHUh?=
NCI-H1581	NFruXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoLrTWM2OD1zMj6yPFE6KM7:TR?=	M165enNCVkeHUh?=
NCI-H23	M{npRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXjJR\|UxRTF{LkOxNlUh\|ryP	MoHKV2FPT0WU
NCI-H596	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkLBTWM2OD1zMj60O\|k5KM7:TR?=	NIr4TZpUSU6JRWK=
NB69	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlL3TWM2OD1zMj63OVg2KM7:TR?=	M{fuTXNCVkeHUh?=
ChaGo-K-1	NUjheG5IT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYrsUmlLUUN3ME2xNk44PjR7IN88US=>	MXfTRW5ITVJ?
EFM-19	MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4fxPGlEPTB;MUKuO\|cyPyEQvF2=	MUfTRW5ITVJ?
SW962	NGTUN5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoKxTWM2OD1zMj64NlI{KM7:TR?=	MXnTRW5ITVJ?
KALS-1	NH\2R3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NInnWFBKSzVyPUGzMlA6PSEQvF2=	NGm5SmdUSU6JRWK=
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SW684	Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MULJR\|UxRTF\|LkG4OlEh\|ryP	M1rkPXNCVkeHUh?=
NCI-H2052	MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXHJR\|UxRTF\|LkO4OFgh\|ryP	NHTkZ3lUSU6JRWK=
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A253	MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MXnJR\|UxRTF2LkKyOUDPxE1?	NFvWZY9USU6JRWK=
NCI-H1155	MmP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\QWI9KSzVyPUG0MlI4PDdizszN	NGnv[WtUSU6JRWK=
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23132-87	M1u3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXLJR\|UxRTF2LkizOVMh\|ryP	NELw[FlUSU6JRWK=
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NCI-H82	NUHLSYFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1zpdGlEPTB;MUmuOlg4QCEQvF2=	NWfUbYJ7W0GQR1XS
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PC-14	M2nvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWjJR\|UxRTJyLkG4N\|Qh\|ryP	M2\3UXNCVkeHUh?=
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RPMI-8226	MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXTGb3RmUUN3ME2yOE4{OTV3IN88US=>	NHvoRY5USU6JRWK=
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SK-N-DZ	NUG3OVhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mn31TWM2OD1{NT6wPVA1KM7:TR?=	M3PzbnNCVkeHUh?=
CAL-85-1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2[5WGlEPTB;MkWuNVU1PCEQvF2=	NVz6e2lGW0GQR1XS
JVM-2	NVuzZYFUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NF\nfJdKSzVyPUK1MlIyOjJizszN	MlT2V2FPT0WU
NCI-H2347	M1nCe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MUPJR\|UxRTJ3LkSyOFkh\|ryP	MoPDV2FPT0WU
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CAMA-1	NXjRb5dGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlL5TWM2OD1{Nj60PFc3KM7:TR?=	NHTOdphUSU6JRWK=
MHH-NB-11	M{Hp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mom3TWM2OD1{Nj61PFUyKM7:TR?=	NXf0e2JDW0GQR1XS
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TE-11	NGXWe\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M1PNdWlEPTB;MkeuO\|M1OiEQvF2=	MoWwV2FPT0WU
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CAL-72	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEXL[4dKSzVyPUK4MlU2PjFizszN	MlWwV2FPT0WU
NCI-H2342	MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3KzcmlEPTB;MkmuN\|gxOyEQvF2=	MnPDV2FPT0WU
NCI-H1651	MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoPPTWM2OD1{OT64OVA{KM7:TR?=	NEfvUlRUSU6JRWK=
OE33	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknNTWM2OD1\|MD6xN\|QzKM7:TR?=	NH3Ve\|NUSU6JRWK=
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TE-5	M2Cy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFzTcWNKSzVyPUOzMlE{PjhizszN	NEDNNItUSU6JRWK=
KM-H2	M{PGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWLJR\|UxRTN\|LkG2PVkh\|ryP	MWDTRW5ITVJ?
OVCAR-3	NGfmOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NYrsTJFEUUN3ME2zN{41OTJ5IN88US=>	NH:yTm1USU6JRWK=
NCI-H1304	NYPPfoN3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NYfyS5lOUUN3ME2zN{43ODN4IN88US=>	MXfTRW5ITVJ?
LU-135	NEXo[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH\XNGZKSzVyPUOzMlcxQDZizszN	MnjhV2FPT0WU
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NCI-H1755	M{S1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M3\jUGlEPTB;M{OuPFEyKM7:TR?=	MUDTRW5ITVJ?
Mo-T	NUfOb297T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlXtTWM2OD1\|Mz64OVk{KM7:TR?=	NV32OnFbW0GQR1XS
SK-OV-3	MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVHOc2J[UUN3ME2zN{45QDV2IN88US=>	NEHa[WZUSU6JRWK=
RCC10RGB	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmDVTWM2OD1\|Mz65OFM{KM7:TR?=	MWDTRW5ITVJ?
COLO-680N	NXfRcm5bT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXuTWM2OD1\|ND6xN\|k4KM7:TR?=	M4[3SXNCVkeHUh?=
KURAMOCHI	Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWXYdZJjUUN3ME2zOE43PDJ3IN88US=>	NWLnPXh7W0GQR1XS
NCI-H661	NEDUWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NX;6Znh3UUN3ME2zOE45PDR6IN88US=>	Ml3FV2FPT0WU
YAPC	NX6xW2FyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUHJR\|UxRTN3Lkm1N\|Mh\|ryP	MmP1V2FPT0WU
NCI-H526	NHnl[YZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkDrTWM2OD1\|Nz6yO\|czKM7:TR?=	NVHyc3Q1W0GQR1XS
A498	NYDIVHdJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NWTMcoI4UUN3ME2zPE4xQTV2IN88US=>	NHqzclBUSU6JRWK=
VMRC-RCZ	NVj3WIFPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX7JR\|UxRTN7LkCwOVQh\|ryP	MVjTRW5ITVJ?
HCT-116	M{D6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlnxTWM2OD1\|OT6wOVgh\|ryP	M3XWbnNCVkeHUh?=
COLO-320-HSR	M1TnTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NHKxZYdKSzVyPUSwMlA1OSEQvF2=	MYnTRW5ITVJ?
OAW-42	MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH\DTlVKSzVyPUSwMlA2PDJizszN	NXXkdVdVW0GQR1XS
SK-MEL-1	NHHNfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmrwTWM2OD12MD6yPVI4KM7:TR?=	NYj1SmtRW0GQR1XS
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CP50-MEL-B	Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTlTWM2OD12MT6wO\|k4KM7:TR?=	M33BOXNCVkeHUh?=
RMG-I	NHjOXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NETrU\|NKSzVyPUSyMlQ6OjFizszN	NF\IRodUSU6JRWK=
D-336MG	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MoP4TWM2OD12Mz6xNVUzKM7:TR?=	MmmxV2FPT0WU
SHP-77	Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MkXDTWM2OD12Mz6xPFI5KM7:TR?=	NY\2WFhOW0GQR1XS
SW872	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVHJR\|UxRTR\|LkKxNlMh\|ryP	NFrqN\|ZUSU6JRWK=
DBTRG-05MG	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NGfGfZZKSzVyPUS0MlY6QTZizszN	M1:1R3NCVkeHUh?=
COLO-678	MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWTJR\|UxRTR3LkewN\|Ih\|ryP	MYnTRW5ITVJ?
EGI-1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHnMRlRKSzVyPUS3MlE5OzNizszN	M2H3PXNCVkeHUh?=
KYSE-70	M121cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MmS3TWM2OD12Nz63NlIzKM7:TR?=	M1\tT3NCVkeHUh?=
BALL-1	NGjxW5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M2XYcWlEPTB;NEeuPFI2PCEQvF2=	MlvhV2FPT0WU
MDA-MB-361	NYDoNG9sT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NE\TUppKSzVyPUS4MlA1PiEQvF2=	NGHqPWFUSU6JRWK=
NCI-H1838	M4TkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mne4TWM2OD12OD6zOFU5KM7:TR?=	MYfTRW5ITVJ?
NCI-H1573	NFu0U\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MkHMTWM2OD12OD62O\|g2KM7:TR?=	MoLRV2FPT0WU
HCC1395	NH2xSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV;JR\|UxRTR6Lkm5NkDPxE1?	NXu5dZdmW0GQR1XS
NCI-H2291	M{fVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NXHVVWhZUUN3ME20PU42QTh6IN88US=>	NF;FdnBUSU6JRWK=
RH-18	NHnKRnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX3JR\|UxRTVyLkC4PFQh\|ryP	MmHiV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

References

[1] GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

Solubility (25°C)

In vitro	DMSO	78 mg/mL (199.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 30% PEG400+0.5% Tween80+5% propylene glycol For best results, use promptly after mixing.	30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download BI-D1870 SDF

Molecular Weight	391.42
Formula	C₁₉H₂₃F₂N₅O₂
CAS No.	501437-28-1
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
BI-D1870 (catalog No.S2843) is found as a racemic mixture?
Answer:
Yes, BI-D1870 (catalog No.S2843) is found as a racemic mixture.

S6 Kinase Signaling Pathway Map

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LY2584702 ^New

LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
LY2584702 Tosylate ^New

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
PF-4708671

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with K_i/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Rapamycin (Sirolimus)

Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.
MK-2206 2HCl

MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

Features:The first allosteric small molecule inhibitor of Akt to enter clinical development.
CHIR-99021 (CT99021) HCl

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.
LY294002

LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family.
3-Methyladenine (3-MA)

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. Solutions of 3-MA are best fresh-prepared by heating.
Everolimus (RAD001)

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay.

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BI-D1870

Cited by 7 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

Choose Your Country or Region

By Signaling Pathways

By product type

BI-D1870

Cited by 7 Publications

4 Customer Reviews

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download BI-D1870 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products0

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)