KU-55933 (ATM Kinase Inhibitor)

Name: KU-55933 (ATM Kinase Inhibitor)
Brand: Selleck Chemicals
SKU: S1092
Rating: 5 (234 reviews)

For research use only.

Catalog No.S1092

234 publications

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/K_i of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.

Selleck's KU-55933 (ATM Kinase Inhibitor) has been cited by 234 publications

Cancer Cell, 2021, S1535-6108(20)30658-9

PubMed: 33450196 ( click the link to review the publication )

Cell, 2019, 178(2):361-373

PubMed: 31204100 ( click the link to review the publication )

Cancer Cell, 2019, 35(5):752-766

PubMed: 31085176 ( click the link to review the publication )

Nature, 2018, 560(7716):112-116

PubMed: 30022158 ( click the link to review the publication )

Cancer Cell, 2017, 32(3):342-359

PubMed: 28898696 ( click the link to review the publication )

Science, 2016, 352(6283):353-8

PubMed: 27013428 ( click the link to review the publication )

Nature, 2015, 528(7582):422-6

PubMed: 26649820 ( click the link to review the publication )

Nature, 2015, 10.1038/nature14328

PubMed: 25799992 ( click the link to review the publication )

Cell, 2013, 155(5):1088-103

PubMed: 24267891 ( click the link to review the publication )

Cancer Discov, 2012, 2(11):1048-63

PubMed: 22915751 ( click the link to review the publication )

Mol Cell, 2021, S1097-2765(20)30951-5

PubMed: 33453166 ( click the link to review the publication )

Nucleic Acids Res, 2021, gkaa1290

PubMed: 33469661 ( click the link to review the publication )

J Cell Biol, 2021, 220(2)e201807163

PubMed: 33404608 ( click the link to review the publication )

Cell Rep, 2021, 34(7):108713

PubMed: 33596428 ( click the link to review the publication )

Cell Rep, 2021, 34(9):108808

PubMed: 33657372 ( click the link to review the publication )

Carcinogenesis, 2021, bgab002

PubMed: 33417668 ( click the link to review the publication )

Cancer Invest, 2021, 1-12

PubMed: 33683975 ( click the link to review the publication )

FEBS Open Bio, 2021, 10.1002/2211-5463.13152

PubMed: 33742560 ( click the link to review the publication )

Cell Death Differ, 2021, 10.1038/s41418-020-00733-4

PubMed: 33531658 ( click the link to review the publication )

EMBO J, 2021, e106336

PubMed: 33595114 ( click the link to review the publication )

Research Square, 2021, 10.21203/rs.3.rs-162979/v1

PubMed: N/A ( click the link to review the publication )

Cell Rep, 2021, 34(7):108744

PubMed: 33596421 ( click the link to review the publication )

Adv Sci (Weinh), 2020, 7(20):2000157

PubMed: 33101843 ( click the link to review the publication )

Mol Cell, 2020, S1097-2765(20)30723-1

PubMed: 33152268 ( click the link to review the publication )
Mol Cell, 2020, 22 pii: S1097-2765(20)30231-8

PubMed: 32353258 ( click the link to review the publication )

Nat Commun, 2020, 11(1):6178

PubMed: 33268790 ( click the link to review the publication )

Nat Commun, 2020, 11(1):5775

PubMed: 33188175 ( click the link to review the publication )

Nat Commun, 2020, 26;11(1):2641

PubMed: 32457376 ( click the link to review the publication )

Nat Commun, 2020, 8;11(1):2876

PubMed: 32513994 ( click the link to review the publication )

Nucleic Acids Res, 2020, 6;48(6):2982-3000

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Cell-Rep, 2020, 18;30-7-:2402-2415-e5

PubMed: 32075772 ( click the link to review the publication )

Cell Rep, 2020, 18;30(7):2083-2093 e5

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Cell Rep, 2020, 14;31(2):107518

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Cell Rep, 2020, 32(9):108080

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Cell Rep, 2020, 31(10):107745

PubMed: 32521270 ( click the link to review the publication )

Elife, 2020, 30;9:e51466

PubMed: 32223892 ( click the link to review the publication )

Cell Mol Life Sci, 2020, 77(4):735-749

PubMed: 31297568 ( click the link to review the publication )

mBio, 2020, 11(1)

PubMed: 32071277 ( click the link to review the publication )

mBio, 2020, 11(3):e01190-20

PubMed: 32546626 ( click the link to review the publication )

Cancers (Basel), 2020, 28;12(6):E1388

PubMed: 32481544 ( click the link to review the publication )

Cancers (Basel), 2020, 12(9)E2467

PubMed: 32878283 ( click the link to review the publication )

PLoS Pathog, 2020, 16(6):e1008514

PubMed: 32479542 ( click the link to review the publication )

Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315206

PubMed: 33356386 ( click the link to review the publication )

Arch Toxicol, 2020, 10.1007/s00204-020-02712-7

PubMed: 32189037 ( click the link to review the publication )

Mol Oncol, 2020, 26

PubMed: 32336009 ( click the link to review the publication )

Aging (Albany NY), 2020, 22;12(6):4688-4710

PubMed: 32201398 ( click the link to review the publication )

DNA Repair (Amst), 2020, 87:102803

PubMed: 31991288 ( click the link to review the publication )

Sci Rep, 2020, 10(1):14455

PubMed: 32879366 ( click the link to review the publication )
Front Pharmacol, 2020, 11:601468

PubMed: 33628174 ( click the link to review the publication )

Cell Mol Biol Lett, 2020,

PubMed: 32874188 ( click the link to review the publication )

PLoS One, 2020, 15(1):e0223463

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Int J Radiat Biol, 2020, 96(4):461-468

PubMed: 31859574 ( click the link to review the publication )

Sci Rep, 2020, 10(1):2200

PubMed: 32042076 ( click the link to review the publication )

Cancers (Basel), 2020, 12(6):1490

PubMed: 32517381 ( click the link to review the publication )

Cancers (Basel), 2020, 12(9):E2356

PubMed: 32825402 ( click the link to review the publication )

Nat Chem Biol, 2020, 10.1038/s41589-020-0600-3

PubMed: 32719556 ( click the link to review the publication )

J Biol Chem, 2020, 295(1):125-137

PubMed: 31753920 ( click the link to review the publication )

Nat Commun, 2020, 11(1):123

PubMed: 31913317 ( click the link to review the publication )

Med Mol Morphol, 2020, 10.1007/s00795-020-00264-4

PubMed: 32816116 ( click the link to review the publication )

Mol Cell, 2019, 75(6):1299-1314

PubMed: 31353207 ( click the link to review the publication )

Mol Cell, 2019, 74(4):651-663.e8

PubMed: 30954402 ( click the link to review the publication )

Nat Commun, 2019, 10(1):2910

PubMed: 31266951 ( click the link to review the publication )

Nat Commun, 2019, 10(1):1577

PubMed: 30952868 ( click the link to review the publication )

Nat Commun, 2019, 10(1):87

PubMed: 30622252 ( click the link to review the publication )

Nucleic Acids Res, 2019, 10.1093/nar/gkz518

PubMed: 31184714 ( click the link to review the publication )

Cancer Res, 2019, 10.1158/0008-5472.CAN-18-3388

PubMed: 31515237 ( click the link to review the publication )

J Cell Biol, 2019, 218(7):2113-2123

PubMed: 31123184 ( click the link to review the publication )

Cell Rep, 2019, 26(8):2194-2211.e6

PubMed: 30784599 ( click the link to review the publication )

Cell Rep, 2019, 28(3):735-745

PubMed: 31315051 ( click the link to review the publication )

Cell Death Differ, 2019, 10.1038/s41418-019-0393-7

PubMed: 31320750 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)

PubMed: 31766690 ( click the link to review the publication )

Cancer Discov, 2019, 9(9):1306-1323

PubMed: 31217297 ( click the link to review the publication )
Mol Cancer Ther, 2019, 18(8):1439-1450

PubMed: 31142662 ( click the link to review the publication )

Mol Oncol, 2019, 13(2):290-306

PubMed: 30422399 ( click the link to review the publication )

Neoplasia, 2019, 21(12):1143-1150

PubMed: 31759252 ( click the link to review the publication )

Oxid Med Cell Longev, 2019, 2019:8535163

PubMed: 31641425 ( click the link to review the publication )

J Cell Physiol, 2019, 234(11):21294-21306

PubMed: 31054162 ( click the link to review the publication )

J Virol, 2019, 93(14)

PubMed: 31043526 ( click the link to review the publication )

Sci Rep, 2019, 9(1):13097

PubMed: 31511540 ( click the link to review the publication )

J Biol Chem, 2019, 294(17):7037-7045

PubMed: 30858175 ( click the link to review the publication )

J Biol Chem, 2019, 294(8):2827-2838

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Retrovirology, 2019, 16(1):13

PubMed: 31036006 ( click the link to review the publication )

Sci Adv, 2019, 5(3):eaav1118

PubMed: 30944854 ( click the link to review the publication )

Sci Adv, 2019, 5(5):eaav3235

PubMed: 31086816 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2018.215210

PubMed: 31727767 ( click the link to review the publication )

Nucleic Acids Res, 2019, 47(10):5243-5259

PubMed: 30976812 ( click the link to review the publication )

Nucleic Acids Res, 2019, 47(21):10977-10993

PubMed: 31612207 ( click the link to review the publication )

Int J Radiat Oncol Biol Phys, 2019, 105(4):861-874

PubMed: 31419512 ( click the link to review the publication )

J Exp Med, 2019, 216(7):1648-1663

PubMed: 31097467 ( click the link to review the publication )

J Pineal Res, 2019, 67(4):e12603

PubMed: 31370106 ( click the link to review the publication )

Nat Cell Biol, 2018, 20(4):413-421

PubMed: 29531308 ( click the link to review the publication )

Cell Res, 2018, 28(7):756-770

PubMed: 29844578 ( click the link to review the publication )

Mol Cell, 2018, 71(2):332-342

PubMed: 30017584 ( click the link to review the publication )

Mol Cell, 2018, 69(5):879-892.e5

PubMed: 29478807 ( click the link to review the publication )

Nat Struct Mol Biol, 2018, 25(3):261-269

PubMed: 29483652 ( click the link to review the publication )

Nat Commun, 2018, 9(1):5351

PubMed: 30559436 ( click the link to review the publication )
Nat Commun, 2018, 9(1):697

PubMed: 29449575 ( click the link to review the publication )

Nat Commun, 2018, 9(1):1317

PubMed: 29615613 ( click the link to review the publication )

Nat Commun, 2018, 13;9(1):2720

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Nucleic Acids Res, 2018, 46(19):10119-10131

PubMed: 30165463 ( click the link to review the publication )

Sci Adv, 2018, 4(12):eaat5077

PubMed: 30585287 ( click the link to review the publication )

Cancer Res, 2018, 78(18):5363-5374

PubMed: 30054334 ( click the link to review the publication )

Cell Rep, 2018, 24(13):3393-3403.e5

PubMed: 30257201 ( click the link to review the publication )

Int J Cancer, 2018,

PubMed: 29363109 ( click the link to review the publication )

Redox Biol, 2018, 14:645-655

PubMed: 29172151 ( click the link to review the publication )

Cancer Lett, 2018, 419:280-290

PubMed: 29378238 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):164

PubMed: 29415984 ( click the link to review the publication )

Cell Death Dis, 2018, 9(6):660

PubMed: 29855474 ( click the link to review the publication )

FASEB J, 2018, 32(4):1818-1829

PubMed: 29162700 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(12):2551-2563

PubMed: 30217967 ( click the link to review the publication )

Hum Mol Genet, 2018, 27(23):4024-4035

PubMed: 30107443 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 39(10):1645-1660

PubMed: 29849127 ( click the link to review the publication )

Acta Pharmacol Sin, 2018, 39(12):1874-1884

PubMed: 29921885 ( click the link to review the publication )

Int J Oncol, 2018, 52(3):709-720

PubMed: 29328365 ( click the link to review the publication )

Virology, 2018, 523:121-128

PubMed: 30119013 ( click the link to review the publication )

Arch Biochem Biophys, 2018, 644:93-99

PubMed: 29352966 ( click the link to review the publication )

Transl Oncol, 2018, 11(4):988-998

PubMed: 29940414 ( click the link to review the publication )

Oncol Rep, 2018, 39(5):2071-2080

PubMed: 29565449 ( click the link to review the publication )

Oncol Rep, 2018, 40(4):2363-2370

PubMed: 30066882 ( click the link to review the publication )

Radiat Res, 2018, 189(5):505-518

PubMed: 29474155 ( click the link to review the publication )
Oncol Lett, 2018, 16(5):6608-6614

PubMed: 30405800 ( click the link to review the publication )

Am J Cancer Res, 2018, 8(9):1697-1711

PubMed: 30323964 ( click the link to review the publication )

Nucleic Acids Res, 2018, 46(16):8311-8325

PubMed: 30010936 ( click the link to review the publication )

Blood, 2017, 129(21):2882-2895

PubMed: 28283481 ( click the link to review the publication )

Nat Commun, 2017, 8(1):2039

PubMed: 29229926 ( click the link to review the publication )

EMBO J, 2017, 2;36(9):1261-1278

PubMed: 28320736 ( click the link to review the publication )

Genes Dev, 2017, 31(7):648-659

PubMed: 28446595 ( click the link to review the publication )

Genes Dev, 2017, 31(3):318-332

PubMed: 28242626 ( click the link to review the publication )

Cancer Res, 2017, 77(17):4567-4578

PubMed: 28698210 ( click the link to review the publication )

J Cell Biol, 2017, 216(3):623-639

PubMed: 28228534 ( click the link to review the publication )

EMBO Rep, 2017, 18(5):781-796

PubMed: 28325772 ( click the link to review the publication )

Cancer Lett, 2017, 390:48-57

PubMed: 28093285 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):133

PubMed: 28950914 ( click the link to review the publication )

Free Radic Biol Med, 2017, 108:750-759

PubMed: 28431961 ( click the link to review the publication )

Cell Death Dis, 2017, 8(8):e3019

PubMed: 28837154 ( click the link to review the publication )

Cell Death Dis, 2017,

PubMed: 28518141 ( click the link to review the publication )

Stem Cells Transl Med, 2017, 6(6):1504-1514

PubMed: 28544661 ( click the link to review the publication )

Sci Total Environ, 2017, 1599:375-390

PubMed: 28477133 ( click the link to review the publication )

Sci Rep, 2017, 7(1):16115

PubMed: 29170437 ( click the link to review the publication )

J Biol Chem, 2017, 292(30):12424-12435

PubMed: 28592488 ( click the link to review the publication )

Int J Oncol, 2017, 50(1):290-296

PubMed: 27959407 ( click the link to review the publication )

Eur J Pharm Sci, 2017, 109:223-232

PubMed: 28822757 ( click the link to review the publication )

Am J Physiol Cell Physiol, 2017, 313(5):C501-C515

PubMed: 28794108 ( click the link to review the publication )

Virology, 2017, 510:9-21

PubMed: 28689087 ( click the link to review the publication )
BMC Cancer, 2017, 17(1):338

PubMed: 28521819 ( click the link to review the publication )

Oncol Rep, 2017, 38(1):591-597

PubMed: 28560404 ( click the link to review the publication )

PLoS One, 2017, 12(7):e0181530

PubMed: 28746371 ( click the link to review the publication )

Nutr Cancer, 2017, 69(8):1281-1289

PubMed: 29111814 ( click the link to review the publication )

Nucleic Acids Res, 2017, 45(18):10564-10582

PubMed: 28985345 ( click the link to review the publication )

Genome Biol, 2017, 18(1):224

PubMed: 29178945 ( click the link to review the publication )

Nat Cell Biol, 2016, 18(12):1357-1366

PubMed: 27820601 ( click the link to review the publication )

Mol Cell, 2016, 61(3):405-418

PubMed: 26774285 ( click the link to review the publication )

Nucleic Acids Res, 2016, 44(10):4745-62

PubMed: 26939887 ( click the link to review the publication )

Genes Dev, 2016, 30(3):321-36

PubMed: 26833731 ( click the link to review the publication )

J Cell Biol, 2016, 212(4):399-408

PubMed: 26880199 ( click the link to review the publication )

Elife, 2016, 10.7554/eLife.15129

PubMed: 27269284 ( click the link to review the publication )

Oncogene, 2016, 35(5):567-76

PubMed: 25893301 ( click the link to review the publication )

Cell Death Discov, 2016, 2:16011

PubMed: 27551505 ( click the link to review the publication )

Cell Death Discovery, 2016, 10.1038/cddiscovery.2016.11

PubMed: ( click the link to review the publication )

FASEB J, 2016, 30(8):2899-914

PubMed: 27142525 ( click the link to review the publication )

Oxid Med Cell Longev, 2016, 2016:4313204

PubMed: 28042385 ( click the link to review the publication )

Cell Discov, 2016, 2:16016

PubMed: 27462463 ( click the link to review the publication )

J Immunol, 2016, 197(7):2918-29

PubMed: 27559048 ( click the link to review the publication )

J Cell Sci, 2016, 129(16):3167-77

PubMed: 27383768 ( click the link to review the publication )

Toxicol Appl Pharmacol, 2016, 292:65-74

PubMed: 26708502 ( click the link to review the publication )

Chem Res Toxicol, 2016, 29(1):26-39

PubMed: 26630137 ( click the link to review the publication )

Cell Cycle, 2016, 15(1):84-94

PubMed: 26771713 ( click the link to review the publication )

BMC Cancer, 2016, 16(1):725

PubMed: 27613518 ( click the link to review the publication )
Cancer Chemother Pharmacol, 2016, 77(1):169-80

PubMed: 26590990 ( click the link to review the publication )

PLoS One, 2016, 11(12):e0167454

PubMed: 27907109 ( click the link to review the publication )

Oncotarget, 2016, 7(38):60807-60822

PubMed: 27602502 ( click the link to review the publication )

Sci Rep, 2016, 6:27379

PubMed: 27271479 ( click the link to review the publication )

Oncotarget, 2016, 7(20):29359-70

PubMed: 27121065 ( click the link to review the publication )

Oncotarget, 2016, 7(31):49800-49818

PubMed: 27391441 ( click the link to review the publication )

Mutat Res Genet Toxicol Environ Mutagen, 2016, 795:1-6

PubMed: 26774662 ( click the link to review the publication )

Nat Cell Biol, 2015, 17(8):1004-13

PubMed: 26214134 ( click the link to review the publication )

Nat Cell Biol, 2015, 17(11):1446-57

PubMed: 26502055 ( click the link to review the publication )

Leukemia, 2015, 29(5):1133-42

PubMed: 25371178 ( click the link to review the publication )

Genes Dev, 2015, 29(11):1151-63

PubMed: 26019174 ( click the link to review the publication )

Nanoscale, 2015, 7(47):20211-9

PubMed: 26575637 ( click the link to review the publication )

Oncogene, 2015, 34(23):2978-90

PubMed: 25132270 ( click the link to review the publication )

Arch Toxicol, 2015, 89(11):2015-25

PubMed: 25294323 ( click the link to review the publication )

PLoS Genet, 2015, 11(10):e1005563

PubMed: 26430909 ( click the link to review the publication )

Am J Cancer Res, 2015, 5(5):1649-64

PubMed: 26175935 ( click the link to review the publication )

Mol Cancer Res, 2015, 13(1):120-9

PubMed: ( click the link to review the publication )

Mol Cancer Res, 2015, 13(1):120-9

PubMed: 25232030 ( click the link to review the publication )

Mol Biol Cell, 2015, 26(12):2217-26

PubMed: 25904336 ( click the link to review the publication )

Sci Rep, 2015, 5:11465

PubMed: 26095524 ( click the link to review the publication )

J Biol Chem, 2015, 290(46):27545-56

PubMed: 26420486 ( click the link to review the publication )

Cell Signal, 2015, 27(5):951-60

PubMed: 25683911 ( click the link to review the publication )

Cancer Biol Ther, 2015, 16(11):1585-92

PubMed: 26382920 ( click the link to review the publication )

Cell Cycle, 2015, 14(4):648-55

PubMed: ( click the link to review the publication )
Cell Cycle, 2015, 14(20):3248-60

PubMed: 26312527 ( click the link to review the publication )

Cell Cycle, 2015, 14(4):648-55

PubMed: 25590338 ( click the link to review the publication )

PLoS One, 2015, 10(11):e0142561

PubMed: 26556501 ( click the link to review the publication )

PLoS One, 2015, 10(12):e0145994

PubMed: 26717578 ( click the link to review the publication )

Int J Radiat Biol, 2015, 10.3109/09553002.2015.1029595

PubMed: 25912236 ( click the link to review the publication )

Cell Biol Int, 2015, 10.1002/cbin.10439

PubMed: 25598069 ( click the link to review the publication )

Anticancer Res, 2015, 35(7):3829-38

PubMed: 26124328 ( click the link to review the publication )

Nat Neurosci, 2014, 17(6):813-21

PubMed: 24793032 ( click the link to review the publication )

Cell Death Differ, 2014, 10.1038/cdd.2014.159

PubMed: 25301067 ( click the link to review the publication )

Mol Cancer, 2014, 13:36

PubMed: 24568192 ( click the link to review the publication )

Oncogene, 2014, 10.1038/onc.2014.268

PubMed: 25132265 ( click the link to review the publication )

Cancer Discov, 2014, 4(10):1198-213

PubMed: 25100205 ( click the link to review the publication )

DNA Repair , 2014, 21:140-7

PubMed: 24795278 ( click the link to review the publication )

Biochim Biophys Acta, 2014, 1843(5):934-44

PubMed: 24480460 ( click the link to review the publication )

Biochim Biophys Acta, 2014, 1842(7):1071-9

PubMed: 24726882 ( click the link to review the publication )

Biochim Biophys Acta, 2014, 1842(7):1088-96

PubMed: 24726884 ( click the link to review the publication )

J Biol Chem, 2014, 289(23):16072-84

PubMed: 24782314 ( click the link to review the publication )

Toxicol Appl Pharm, 2014, 282(2):227-236

PubMed: 25450480 ( click the link to review the publication )

Cell Cycle, 2014, 13(11):1777-87

PubMed: 24732096 ( click the link to review the publication )

Neurotox Res, 2014, 25(2):193-207

PubMed: 23996700 ( click the link to review the publication )

Radiat Res, 2014, 181(6):650-8

PubMed: 24785587 ( click the link to review the publication )

Theriogenology, 2014, 12(5):e1001856

PubMed: 24800743 ( click the link to review the publication )

Proteomes, 2014, 2, 451-467

PubMed: ( click the link to review the publication )

Julius Maximilians Universit, 2014, Kumari G

PubMed: ( click the link to review the publication )
Proteomes, 2014, 2(3):451-467

PubMed: 28250390 ( click the link to review the publication )

PLoS One, 2014, 9(6):e98891

PubMed: 24902048 ( click the link to review the publication )

Nucleic Acids Res, 2013, 41(22):10157-69

PubMed: 24021630 ( click the link to review the publication )

Sci Signal, 2013, 6(259):ra5

PubMed: 23354688 ( click the link to review the publication )

FEBS Lett, 2013, 587(21):3437-43

PubMed: 24021642 ( click the link to review the publication )

PLoS One, 2013, 9(1):e84899

PubMed: 24454762 ( click the link to review the publication )

PLoS One, 2013, 8(11):e80313

PubMed: 24282534 ( click the link to review the publication )

J Gen Virol, 2013, 94(Pt 12):2664-2669

PubMed: 24045107 ( click the link to review the publication )

Cell Cycle, 2013, 12(7):1105-18

PubMed: 23462183 ( click the link to review the publication )

Autophagy, 2012, 8(2):236-51

PubMed: 22240589 ( click the link to review the publication )

J Immunol, 2012, 188(5):2266-75

PubMed: 22287717 ( click the link to review the publication )

J Biol Chem, 2012, 287(26):22112-22

PubMed: 22566699 ( click the link to review the publication )

J Biol Chem, 2012, 287(12):8803-15

PubMed: 22270370 ( click the link to review the publication )

Food Chem Toxicol, 2012, 55:214-21

PubMed: 23274058 ( click the link to review the publication )

Int J Radiat Biol, 2012, 88(7):507-14

PubMed: 22449004 ( click the link to review the publication )

J Virol, 2011, 85(23):12547-56

PubMed: 21917957 ( click the link to review the publication )

J Biol Chem, 2011, 286(10):8394-404

PubMed: 21148313 ( click the link to review the publication )

Mech Ageing Dev, 2011, 132(11-12):543-51

PubMed: 21945951 ( click the link to review the publication )

Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Biological Activity

Description

Targets

ATM ^[1]
(Cell-free assay)

12.9 nM

In vitro

KU-55933 inhibits DNA-PK and PI3K with IC50 of 2.5 μM and 16.6 μM, respectively. Besides, KU-55933 also prevents the activity of mTOR with IC50 of 9.3 μM. KU-55933 is active at the cellular level in ablating a well-characterized ATM-dependent phosphorylation event. KU-55933 has a dose-dependent effect in inhibiting this ATM-dependent phosphorylation event with IC50 of 300 nM. KU-58050 does not prevent the ATM-dependent phosphorylation of p53 serine 15 until a dose of 30 μM. Addition of KU-55933 has no appreciable effects on UV-induced phosphorylation of H2AX on serine 139, NBS1 on serine 343, CHK1 on serine 345, and SMC1 on serine 966. In stark contrast to the UV responses, KU-55933 ablates the ionizing radiation-induced phosphorylation of these ATM substrates. KU-55933 sensitizes HeLa cells to a range of ionizing radiation doses. ^[1] KU-55933 inhibits the phosphorylation of Akt induced by growth factors in cancer cells. KU-55933 suppresses the proliferation of cancer cells. Furthermore, suppression of ATM by KU-55933 improves survival, probably via prevention of downstream activation of TAp63α. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
DU-145	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXjJR\|UxRTNwMkezOVIh\|ryP	MoDRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuO-3N1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVPJR\|UxRTRwMUexOFIh\|ryP	M{XER\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LAMA-84	M1jEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIPobGlKSzVyPUSuOVg1PjVizszN	NFj4eI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CAL-72	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NU\QZ4V[UUN3ME21MlQ5ODh2IN88US=>	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
LoVo	NV\LdmhvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4SydWlEPTB;Nj65N\|I{QSEQvF2=	NIi2O5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HH	M1j6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGHhc\|RKSzVyPUiuNlc3PzFizszN	NY\UNGJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-MEL-3	M{jBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVXic5ZxUUN3ME24MlI5PTd3IN88US=>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
KM12	M2m2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoCyTWM2OD17LkKxNVQzKM7:TR?=	NV31c4ZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H1437	M4jvUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEm0TpVKSzVyPUmuPFA6PyEQvF2=	M1fJZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
NCI-H1838	M3nuVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXX2OGI3UUN3ME2xNU4yQDZ3IN88US=>	NGLzclU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
J-RT3-T3-5	NHW1XYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnLJTWM2OD1zMT6yOFE4KM7:TR?=	NGXtZno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
GOTO	MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmXrTWM2OD1zMT62PVk3KM7:TR?=	NVrSN3lURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LB2241-RCC	NFjCeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVPJR\|UxRTFzLkexPFYh\|ryP	M1PadVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
ES7	NGLWcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUX5WGtKUUN3ME2xNU44QDhizszN	NWfVXlBFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KP-N-YS	MnzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXfJR\|UxRTF{Lk[zOVQh\|ryP	MlXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-12T	NHLr[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVTxVI5KUUN3ME2xN{43OTdizszN	MojoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
COLO-684	NEPMOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX3BdVJxUUN3ME2xOE4yPTZ7IN88US=>	NHG0VoU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
DOK	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVK0Xo9uUUN3ME2xOU4{OzJ7IN88US=>	NISwOWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
Hs-578-T	M3rsTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUPaO4lUUUN3ME2xOU41OTh{IN88US=>	MkPjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
D-423MG	NH\ObVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mk\UTWM2OD1zNT61NlM3KM7:TR?=	NFn4WGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
DBTRG-05MG	NHOweHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVK1ZYJyUUN3ME2xOU43OTFzIN88US=>	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
VM-CUB-1	M2rwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkjETWM2OD1zNT65PFQ6KM7:TR?=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
KG-1	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWTJR\|UxRTF4LkC5PVYh\|ryP	M1SwTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
8305C	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHW4VYxKSzVyPUG2MlE5QDlizszN	M1yxNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HuH-7	NU\NZ5cxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEDKcYpKSzVyPUG2MlI3PzRizszN	NH:5R4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
LXF-289	Ml3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{L0S2lEPTB;MU[uNlc1PyEQvF2=	Ml;EQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1793	NHrEZmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUW2fmhMUUN3ME2xOk41PzF{IN88US=>	NELEZW09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
ChaGo-K-1	NW[y[Gp7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2fQSmlEPTB;MU[uOlU3QCEQvF2=	NHHsfGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
GCIY	MnjTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkTCTWM2OD1zNj63PVA2KM7:TR?=	NUToUmRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
SK-MEL-28	NIOy[oRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXfJR\|UxRTF5LkC0O\|Uh\|ryP	NXnWeot3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-SNU-1	NY\q[npVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVzJR\|UxRTF5LkGyOlkh\|ryP	NGDm[Wc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CTB-1	NIfhZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlXmTWM2OD1zNz6yNlU6KM7:TR?=	MnHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H82	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX\zXHR7UUN3ME2xO{41PTd\|IN88US=>	NVryfpB3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HCC2998	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVXJNHdHUUN3ME2xO{43PzN\|IN88US=>	NH\W[Is9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
NCI-H2030	M4PGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHHxVXRKSzVyPUG4MlE6QTdizszN	NGLUO5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HuP-T3	M3XHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWrJR\|UxRTF6LkW4PFgh\|ryP	MmS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
697	NIPvT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4LORWlEPTB;MUmuNFIxOSEQvF2=	NYL2WllIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
MLMA	NFLoOW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnTDTWM2OD1zOT6wOVU4KM7:TR?=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HCC70	NV64c5duT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoSwTWM2OD1zOT60PFkh\|ryP	NEj0boU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
A704	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1;oVWlEPTB;MUmuPFMxPSEQvF2=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
D-283MED	NXTreoQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH:yenpKSzVyPUKwMlU{OzlizszN	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
U031	NIXEb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYDnb2xpUUN3ME2yNU4yPDh7IN88US=>	MkewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HSC-3	NHLkT2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF3pRZJKSzVyPUKxMlE5OzVizszN	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
JVM-3	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml;STWM2OD1{Mj61NFYh\|ryP	M2TiXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
Mewo	NHzMXVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4rx[2lEPTB;MkKuOVA4OyEQvF2=	NI\TUGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
YH-13	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DDNWlEPTB;MkKuOVEzOyEQvF2=	NX;JOVVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
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EPLC-272H	M{Dqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFrib2NKSzVyPUS2Mlk2ODNizszN	NXG2N3NURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
BALL-1	NE\ZcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV3JR\|UxRTR5LkizNkDPxE1?	M{HGXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
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IMR-32	MomySpVv[3Srb36gRZN{[Xl?	NVvIUppSOTEEoN88UeKh	M4fxWlI1KGh?		NYPVRYQzcW6qaXLpeJMh[2yrb4H1bY5wdC2rbnT1Z4VlKHCqb4PwbI9zgWyjdHnvckBw\iCyNUO=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ{N{K5OEc,OjJ4MkeyPVQ9N2F-
A549	MmXVSpVv[3Srb36gRZN{[Xl?	MlLHNVDDqM7:TdMg	MWqxJIg>		NHLo[\|V{fXCycnXzd4V{KE6jbn:tR48ucW6mdXPl[EBxPTNiYXPjeY12dGG2aX;u	M4r0T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUW5N\|IyLz5{MkW1PVMzOTxxYU6=
T47D	M2fHSWZ2dmO2aX;uJGF{e2G7	MX:yNOKhdU1?	M4\FOlI1KGh?	M{fTUmROW09?	MmXYdJJmfmWwdIOgTXIucW6mdXPl[EBl\We{YXTheIlwdiCxZjDJ{tpD\|rF?	M2LkdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMUS0PFA2Lz5{MUG0OFgxPTxxYU6=
A29 MEF	M4r1bWZ2dmO2aX;uJGF{e2G7	MYOxNOKh\|ryPwrC=	M1LVPFFp		Ml\DZoxw[2u\|wrD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGtdDDheEBU\XJ2N{RCpC=>	NXyxWY1WRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
MDA-MB-453	NE\3TYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	Mom0OU01OCEQvF2=	NYi2eJVvPzJiaB?=		NFXac3pKSzVyIH;mJFExKM7:TR?=	MnPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNUO3PFEoRjJyMEWzO\|gyRC:jPh?=
PC-3	NHfKSGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NIm3RWU2NTRyIN88US=>	MonjO\|IhcA>?		NF\JS5pKSzVyIH;mJFExKM7:TR?=	NVrpbZZRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
U2OS	MYTGeY5kfGmxbjDhd5NigQ>?				NIi0V2JKdmirYnn0bY9vKG:oIFHUUUBqdiCqdX3hckBWOk:VIHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YheDV\|IIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIyPSC{ZYPp[JVmNCCLQ{WwJF0hOC5{NTFOwG0v	M1HM[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
MCF7	M3i2V2Z2dmO2aX;uJIF{e2G7		MofLNUBpeg>?		MU\Jcohq[mm2aX;uJI9nKEGWTTDrbY5ie2ViaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiBzIHjyJIJ6KGmvbYXuc4ZtfW:{ZYPj[Y5k\SCjc4PhfUwhUUN3MDC9JFAvOyEQvF2u	MojQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{K5OlUoRjJ4NkOyPVY2RC:jPh?=
BJ	MlLqSpVv[3Srb36gZZN{[Xl?	MUKxNEB2VQ>?	MlLkNVAh\GG7cx?=		M{fY[HN2eHC{ZYPzbY9vKG:oIIPlcoV{[2WwY3WgbY4hcHWvYX6gRmoh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iY3XscEBvfW2kZYKgZZQhOTBidV2gZYZ1\XJiMUCg[IF6eyCkeTDz[Y5me2OnbnPlJJJmfmW{c3HsJIF{e2G7	NILpWFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke2O\|A5PSd-MU[3OlcxQDV:L3G+
BJ	MoT5SpVv[3Srb36gZZN{[Xl?	MmHtNVAhfU1?	Ml;INVAh\GG7cx?=		NYrnSHZIUW6qaXLpeIlwdiCxZjDheIF5cWFidHXsZY5ocWWldHHzbYEudXW2YYTl[EBqdiCqdX3hckBDUiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDj[YxtKG63bXLldkBifCBzMDD1UUBi\nSncjCxNEBl[Xm\|IHL5JJNmdmW\|Y3XuZ4UhemW4ZYLzZYwh[XO\|YYm=	Mn3FQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5NkewPFUoRjF4N{[3NFg2RC:jPh?=
MCF7	NHrGclBHfW6ldHnvckBie3OjeR?=	Mlz4NVAhfU1?	M2eyXVExKG2rboO=		NWfIXlN1W2Wwc3n0bZpifGmxbjDv[kBqdm[{YYLl[E1qdmS3Y3XkJGRPSSCmYX3h[4UhcW5iaIXtZY4hVUOINzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2:ub375JIZwem2jdHnvckBifCBzMDD1UUBxemW2cnXheIVlKG[xcjCxNEBucW6\|IH\vcIxwf2WmIHL5JIlzemGmaXH0bY9vKG[xcjC0JIhzeyCvZXHzeZJm\CCjZoTldkAyOCCmYYnzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nJIFv[Wy7c3nz	MkLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{K5OlUoRjJ4NkOyPVY2RC:jPh?=
SK-N-MC	MWDxTHRUKGG\|c3H5				NGS5dHhyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=>	NYHnfGNxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>

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Assay

Methods	Test Index	PMID
Western blot	p-AKT(Ser473) / p-AKT(Thr308); PubMed: 22739265 Chin J Cancer Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖 PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; PubMed: 22739265 Chin J Cancer ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤 ATM-S1981 / ATM / p-p53(S15) / p53 ; PubMed: 20639198 J Biol Chem Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖 p21 / p27 / p53 ; PubMed: 20177072 J Biol Chem HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.	22739265 20639198 20177072
Immunofluorescence	p-S824 KAP1 / ZEBRA ; PubMed: 28249048 PLoS Pathog HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.	28249048

In vivo

Suppression of ATM-dependent STAT3 activation by KU-55933 enhances TRAIL-mediated apoptosis through up-regulation of surface DR5 expression, whereas suppression of both STAT3 and NF-κB appeares to be involved in down-regulation of cFLIP accompanied by an additional increase in apoptotic levels. The ATM inhibitor KU-55933 affectes TRAIL-mediated apoptosis more strongly than the JAK2 inhibitor, AG490, or overexpression of STAT3β. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse Purified enzyme assays: ATM for use in the in vitro assay is obtained from HeLa nuclear extract by immunoprecipitation with rabbit polyclonal antiserum raised to the COOH-terminal 400 amino acids of ATM in buffer containing 25 mM HEPES (pH 7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v glycerol, and 0.1% v/v Igepal. ATM-antibody complexes are isolated from nuclear extract by incubating with protein A-Sepharose beads for 1 hour and then through centrifugation to recover the beads. In the well of a 96-well plate, ATM-containing Sepharose beads are incubated with 1 μg of substrate glutathione S-transferase–p53N66 (NH₂-terminal 66 amino acids of p53 fused to glutathione S-transferase) in ATM assay buffer [25 mM HEPES (pH 7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT, and 5% v/v glycerol] at 37 °C in the presence or absence of inhibitor. After 10 minutes with gentle shaking, ATP is added to a final concentration of 50 μM and the reaction continued at 37 °C for an additional 1 hour. The plate is centrifuged at 250 × g for 10 minutes (4 °C) to remove the ATM-containing beads, and the supernatant is removed and transferred to a white opaque 96-well plate and incubated at room temperature for 1.5 hours to allow glutathione S-transferase-p53N66 binding. This plate is then washed with PBS, blotted dry, and analyzed by a standard ELISA technique with a phospho-serine 15 p53 antibody. The detection of phosphorylated glutathione S-transferase-p53N66 substrate is performed in combination with a goat antimouse horseradish peroxidase-conjugated secondary antibody. Enhanced chemiluminescence solution is used to produce a signal and chemiluminescent detection is carried out.
Cell Research: ^[1]	- Collapse Cell lines: U2OS cells Concentrations: 10 μM Incubation Time: 2 hours Method: U2OS cells are exposed to ionizing radiation (3, 5, or 15 Gy) or UV (5 or 50 J/m²) and the ATM response determined by Western blot analysis of p53 serine 15 phosphorylation and stabilization of wild-type p53. Whole cell extracts are obtained from each time point, proteins separated by SDS-PAGE, and the ATM-specific increase in phosphorylated serine 15 measured with a p53 phospho-serine 15 specific antibody. Overall p53 stabilization with time is also observed with a p53-specific antibody (DO-1). Similarly, for studying ATM-dependent phosphorylations on H2AX, CHK1, NBS1, and SMC1, the following antibodies are used: CHK1 phospho-serine 345 and NBS1 phospho-serine 343 antibodies. Histone H2A (H-124) and CHK1 antibodies are also used, as well as SMC1 and SMC1 phospho-serine 966 antibodies. For determination of a cellular IC50 for KU-55933, the peak response time for p53 serine 15 phosphorylation of 2 hours is used to monitor inhibition of ATM. KU-55933 is titrated onto cells and preincubated for 1 hour before ionizing radiation. Using scanning densitometry, the percentage inhibition relative to vehicle control is calculated, and the IC50 value is calculated as for the in vitro determinations. (Only for Reference)
Animal Research: ^[3]	- Collapse Animal Models: BALB/c nu/nu nude mice bearing LU1205 cells Dosages: 10 μM Administration: -- (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	33 mg/mL (83.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	3.95 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download KU-55933 (ATM Kinase Inhibitor) SDF

Molecular Weight	395.49
Formula	C₂₁H₁₇NO₃S₂
CAS No.	587871-26-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

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ATM/ATR Signaling Pathway Map

ATM/ATR Inhibitors with Unique Features

Pan ATM/ATR Inhibitor

CGK 733 : Dual ATM/ATR inhibitor, IC50=~200 nM.
Most Potent ATM/ATR Inhibitor

AZ20 ^New : ATR, IC50=5 nM.
ATM/ATR Inhibitor in Clinical Trial

BEZ235 (NVP-BEZ235, Dactolisib) : Phase II for Advanced Endometrial Carcinoma.
Newest ATM/ATR Inhibitor

VE-822 ^New : ATR inhibitor with IC50 of 19 nM.

Related ATM/ATR Products

Ceralasertib (AZD6738) ^New

Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2.
CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
Dorsomorphin (Compound C) ^New

Dorsomorphin (Compound C, BML-275) is a potent, reversible, selective AMPK inhibitor with K_i of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For animal testing, the water-soluble S7306 Dorsomorphin (Compound C) 2HCl is recommended.
VE-821

VE-821 is a potent and selective ATP competitive inhibitor of ATR with K_i/IC50 of 13 nM/26 nM in cell-free assays, shows inhibition of H2AX phosphorylation, minimal activity against PIKKs ATM, DNA-PK, mTOR and PI3Kγ.
KU-60019

KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.

Features:Improved analog of KU-55933, and is more effective at blocking ATM-mediated DDR events.
Berzosertib (VE-822)

Berzosertib (VE-822, VX970, M6620) is an ATR inhibitor with IC50 of 19 nM in HT29 cells.

Features:VE-822 is a highly selective and potent derivative of the ATR inhibitor VE-821.
Chloroquine diphosphate

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Chloroquine is also an inhibitor of toll-like receptors (TLRs).
AZ20

AZ20 is a novel potent and selective inhibitor of ATR kinase with IC50 of 5 nM in a cell-free assay, 8-fold selectivity over mTOR.

Features:AZ20 is the first reported inhibitor of ATR protein kinase demonstrating tumor growth inhibition in vivo.
CP-466722

CP-466722 is a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.
ETP-46464

ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.

Features:Selective ATR inhibitor and particularly toxic to p53-deficient cancer cells. Often used as a pharmacologic probe due to its ideal pharmacological properties.

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KU-55933 (ATM Kinase Inhibitor)