KU-55933 (ATM Kinase Inhibitor)

Name: KU-55933 (ATM Kinase Inhibitor)
Brand: Selleck Chemicals
SKU: S1092
Rating: 5 (250 reviews)

For research use only.

Catalog No.S1092

250 publications

KU-55933 (ATM Kinase Inhibitor) Chemical Structure

CAS No. 587871-26-9

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/K_i of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.

Selleck's KU-55933 (ATM Kinase Inhibitor) has been cited by 250 publications

Cancer Cell, 2021, S1535-6108(20)30658-9

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Cell, 2019, 178(2):361-373

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Cancer Cell, 2019, 35(5):752-766

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Nature, 2018, 560(7716):112-116

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Cancer Cell, 2017, 32(3):342-359

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Science, 2016, 352(6283):353-8

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Cell, 2016, 167(6):1571-1585.e18

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Nature, 2015, 528(7582):422-6

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Nature, 2015, 10.1038/nature14328

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Cell, 2013, 155(5):1088-103

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Cancer Discov, 2012, 2(11):1048-63

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Mol Cell, 2021, S1097-2765(21)00315-4

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Mol Cell, 2021, S1097-2765(20)30951-5

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Sci Adv, 2021, 7(25)eabd9208

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Nat Commun, 2021, 12(1):3827

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Nucleic Acids Res, 2021, gkaa1290

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Nucleic Acids Res, 2021, gkab584

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J Cell Biol, 2021, 220(2)e201807163

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Cell Rep, 2021, 34(7):108713

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Cell Rep, 2021, 35(13):109306

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Autophagy, 2021, 10.1080/15548627.2021.1936932

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J Exp Clin Cancer Res, 2021, 40(1):224

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Front Cell Dev Biol, 2021, 9:649328

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Carcinogenesis, 2021, bgab002

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DNA Repair (Amst), 2021, 104:103136

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J Cell Mol Med, 2021, 10.1111/jcmm.16751

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Eur J Pharmacol, 2021, 907:174303

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Cancer Invest, 2021, 1-12

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FEBS Open Bio, 2021, 10.1002/2211-5463.13152

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Cell Death Differ, 2021, 10.1038/s41418-020-00733-4

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Commun Biol, 2021, 4(1):484

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Research Square, 2021, 10.21203/rs.3.rs-162979/v1

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EMBO J, 2021, e106336

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Research Square, 2021, 10.21203/rs.3.rs-162979/v1

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Cell Rep, 2021, 34(7):108744

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Adv Sci (Weinh), 2020, 7(20):2000157

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Mol Cell, 2020, S1097-2765(20)30723-1

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Mol Cell, 2020, 22 pii: S1097-2765(20)30231-8

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Nat Commun, 2020, 11(1):6178

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Nat Commun, 2020, 26;11(1):2641

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Nat Commun, 2020, 8;11(1):2876

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Nucleic Acids Res, 2020, 6;48(6):2982-3000

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Cell-Rep, 2020, 18;30-7-:2402-2415-e5

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Cell Rep, 2020, 14;31(2):107518

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Elife, 2020, 30;9:e51466

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Cell Mol Life Sci, 2020, 77(4):735-749

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mBio, 2020, 11(1)

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mBio, 2020, 11(3):e01190-20

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Cancers (Basel), 2020, 28;12(6):E1388

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Cancers (Basel), 2020, 12(9)E2467

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PLoS Pathog, 2020, 16(6):e1008514

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Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315206

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Arch Toxicol, 2020, 10.1007/s00204-020-02712-7

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Mol Oncol, 2020, 26

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Aging (Albany NY), 2020, 22;12(6):4688-4710

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DNA Repair (Amst), 2020, 87:102803

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Sci Rep, 2020, 10(1):14455

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Front Pharmacol, 2020, 11:601468

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Cell Mol Biol Lett, 2020,

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PLoS One, 2020, 15(1):e0223463

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Int J Radiat Biol, 2020, 96(4):461-468

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Sci Rep, 2020, 10(1):2200

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Cancers (Basel), 2020, 12(6):1490

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Cancers (Basel), 2020, 12(9):E2356

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Nat Chem Biol, 2020, 10.1038/s41589-020-0600-3

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J Biol Chem, 2020, 295(1):125-137

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Nat Commun, 2020, 11(1):123

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Mol Cell, 2019, 75(6):1299-1314

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Nat Commun, 2019, 10(1):2910

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Nat Commun, 2019, 10(1):1577

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Nat Commun, 2019, 10(1):87

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Nucleic Acids Res, 2019, 10.1093/nar/gkz518

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Cancer Res, 2019, 10.1158/0008-5472.CAN-18-3388

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J Cell Biol, 2019, 218(7):2113-2123

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Cell Rep, 2019, 26(8):2194-2211.e6

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Cell Rep, 2019, 28(3):735-745

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Cell Death Differ, 2019, 10.1038/s41418-019-0393-7

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Cancers (Basel), 2019, 11(12)

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Cancer Discov, 2019, 9(9):1306-1323

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Mol Cancer Ther, 2019, 18(8):1439-1450

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Mol Oncol, 2019, 13(2):290-306

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Neoplasia, 2019, 21(12):1143-1150

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Oxid Med Cell Longev, 2019, 2019:8535163

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J Cell Physiol, 2019, 234(11):21294-21306

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J Virol, 2019, 93(14)

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Sci Rep, 2019, 9(1):13097

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Retrovirology, 2019, 16(1):13

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Haematologica, 2019, 10.3324/haematol.2018.215210

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Nucleic Acids Res, 2019, 47(10):5243-5259

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Nucleic Acids Res, 2019, 47(21):10977-10993

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Int J Radiat Oncol Biol Phys, 2019, 105(4):861-874

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J Pineal Res, 2019, 67(4):e12603

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Nat Cell Biol, 2018, 20(4):413-421

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Cell Res, 2018, 28(7):756-770

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Mol Cell, 2018, 71(2):332-342

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Mol Cell, 2018, 69(5):879-892.e5

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Nat Struct Mol Biol, 2018, 25(3):261-269

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Nat Commun, 2018, 9(1):5351

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Nat Commun, 2018, 9(1):697

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Nat Commun, 2018, 9(1):1317

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Nat Commun, 2018, 13;9(1):2720

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Nucleic Acids Res, 2018, 46(19):10119-10131

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Sci Adv, 2018, 4(12):eaat5077

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Cancer Res, 2018, 78(18):5363-5374

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Cell Rep, 2018, 24(13):3393-3403.e5

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Int J Cancer, 2018,

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Redox Biol, 2018, 14:645-655

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Cancer Lett, 2018, 419:280-290

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Cell Death Dis, 2018, 9(2):164

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Cell Death Dis, 2018, 9(6):660

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FASEB J, 2018, 32(4):1818-1829

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Mol Cancer Ther, 2018, 17(12):2551-2563

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Hum Mol Genet, 2018, 27(23):4024-4035

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Acta Pharmacol Sin, 2018, 39(10):1645-1660

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Acta Pharmacol Sin, 2018, 39(12):1874-1884

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Int J Oncol, 2018, 52(3):709-720

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Virology, 2018, 523:121-128

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Transl Oncol, 2018, 11(4):988-998

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Oncol Rep, 2018, 39(5):2071-2080

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Oncol Rep, 2018, 40(4):2363-2370

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Radiat Res, 2018, 189(5):505-518

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Oncol Lett, 2018, 16(5):6608-6614

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Nucleic Acids Res, 2018, 46(16):8311-8325

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Blood, 2017, 129(21):2882-2895

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Nat Commun, 2017, 8(1):2039

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EMBO J, 2017, 2;36(9):1261-1278

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Genes Dev, 2017, 31(7):648-659

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Genes Dev, 2017, 31(3):318-332

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Cancer Res, 2017, 77(17):4567-4578

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J Cell Biol, 2017, 216(3):623-639

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EMBO Rep, 2017, 18(5):781-796

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Cancer Lett, 2017, 390:48-57

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J Exp Clin Cancer Res, 2017, 36(1):133

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Free Radic Biol Med, 2017, 108:750-759

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Cell Death Dis, 2017, 8(8):e3019

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Cell Death Dis, 2017,

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Stem Cells Transl Med, 2017, 6(6):1504-1514

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Sci Total Environ, 2017, 1599:375-390

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Sci Rep, 2017, 7(1):16115

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Int J Oncol, 2017, 50(1):290-296

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Eur J Pharm Sci, 2017, 109:223-232

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Am J Physiol Cell Physiol, 2017, 313(5):C501-C515

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Virology, 2017, 510:9-21

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BMC Cancer, 2017, 17(1):338

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Oncol Rep, 2017, 38(1):591-597

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PLoS One, 2017, 12(7):e0181530

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Nutr Cancer, 2017, 69(8):1281-1289

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Nucleic Acids Res, 2017, 45(18):10564-10582

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Genome Biol, 2017, 18(1):224

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Nat Cell Biol, 2016, 18(12):1357-1366

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Mol Cell, 2016, 61(3):405-418

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Nucleic Acids Res, 2016, 44(10):4745-62

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Genes Dev, 2016, 30(3):321-36

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J Cell Biol, 2016, 212(4):399-408

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Elife, 2016, 10.7554/eLife.15129

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Oncogene, 2016, 35(5):567-76

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Cell Death Discov, 2016, 2:16011

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Cell Death Discovery, 2016, 10.1038/cddiscovery.2016.11

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FASEB J, 2016, 30(8):2899-914

PubMed: 27142525 ( click the link to review the publication )

Oxid Med Cell Longev, 2016, 2016:4313204

PubMed: 28042385 ( click the link to review the publication )

Cell Discov, 2016, 2:16016

PubMed: 27462463 ( click the link to review the publication )

J Immunol, 2016, 197(7):2918-29

PubMed: 27559048 ( click the link to review the publication )

J Cell Sci, 2016, 129(16):3167-77

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Sci Rep, 2016, 6:22972

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Toxicol Appl Pharmacol, 2016, 292:65-74

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Chem Res Toxicol, 2016, 29(1):26-39

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Cell Cycle, 2016, 15(1):84-94

PubMed: 26771713 ( click the link to review the publication )

BMC Cancer, 2016, 16(1):725

PubMed: 27613518 ( click the link to review the publication )

Cancer Chemother Pharmacol, 2016, 77(1):169-80

PubMed: 26590990 ( click the link to review the publication )

PLoS One, 2016, 11(12):e0167454

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Oncotarget, 2016, 7(38):60807-60822

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Sci Rep, 2016, 6:27379

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Oncotarget, 2016, 7(20):29359-70

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Oncotarget, 2016, 7(31):49800-49818

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Mutat Res Genet Toxicol Environ Mutagen, 2016, 795:1-6

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Nat Cell Biol, 2015, 17(8):1004-13

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Nat Cell Biol, 2015, 17(11):1446-57

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Leukemia, 2015, 29(5):1133-42

PubMed: 25371178 ( click the link to review the publication )

Genes Dev, 2015, 29(11):1151-63

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Nanoscale, 2015, 7(47):20211-9

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Oncogene, 2015, 34(23):2978-90

PubMed: 25132270 ( click the link to review the publication )

Arch Toxicol, 2015, 89(11):2015-25

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PLoS Genet, 2015, 11(10):e1005563

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Am J Cancer Res, 2015, 5(5):1649-64

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Mol Cancer Res, 2015, 13(1):120-9

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Mol Cancer Res, 2015, 13(1):120-9

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Mol Biol Cell, 2015, 26(12):2217-26

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Sci Rep, 2015, 5:11465

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J Biol Chem, 2015, 290(46):27545-56

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Cell Signal, 2015, 27(5):951-60

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Cancer Biol Ther, 2015, 16(11):1585-92

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Cell Cycle, 2015, 14(4):648-55

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Cell Cycle, 2015, 14(20):3248-60

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Cell Cycle, 2015, 14(4):648-55

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PLoS One, 2015, 10(11):e0142561

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PLoS One, 2015, 10(12):e0145994

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Int J Radiat Biol, 2015, 10.3109/09553002.2015.1029595

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Cell Biol Int, 2015, 10.1002/cbin.10439

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Anticancer Res, 2015, 35(7):3829-38

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Nat Neurosci, 2014, 17(6):813-21

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Cell Death Differ, 2014, 10.1038/cdd.2014.159

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Mol Cancer, 2014, 13:36

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Oncogene, 2014, 10.1038/onc.2014.268

PubMed: 25132265 ( click the link to review the publication )

Cancer Discov, 2014, 4(10):1198-213

PubMed: 25100205 ( click the link to review the publication )

DNA Repair , 2014, 21:140-7

PubMed: 24795278 ( click the link to review the publication )

Biochim Biophys Acta, 2014, 1843(5):934-44

PubMed: 24480460 ( click the link to review the publication )

Biochim Biophys Acta, 2014, 1842(7):1071-9

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Biochim Biophys Acta, 2014, 1842(7):1088-96

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J Biol Chem, 2014, 289(23):16072-84

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Toxicol Appl Pharm, 2014, 282(2):227-236

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Cell Cycle, 2014, 13(11):1777-87

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Neurotox Res, 2014, 25(2):193-207

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Radiat Res, 2014, 181(6):650-8

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Theriogenology, 2014, 12(5):e1001856

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Proteomes, 2014, 2, 451-467

PubMed: ( click the link to review the publication )

Julius Maximilians Universit, 2014, Kumari G

PubMed: ( click the link to review the publication )

Proteomes, 2014, 2(3):451-467

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PLoS One, 2014, 9(6):e98891

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Nucleic Acids Res, 2013, 41(22):10157-69

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Sci Signal, 2013, 6(259):ra5

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FEBS Lett, 2013, 587(21):3437-43

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PLoS One, 2013, 9(1):e84899

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Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Biological Activity

Description

Targets

ATM ^[1]
(Cell-free assay)

12.9 nM

In vitro

KU-55933 inhibits DNA-PK and PI3K with IC50 of 2.5 μM and 16.6 μM, respectively. Besides, KU-55933 also prevents the activity of mTOR with IC50 of 9.3 μM. KU-55933 is active at the cellular level in ablating a well-characterized ATM-dependent phosphorylation event. KU-55933 has a dose-dependent effect in inhibiting this ATM-dependent phosphorylation event with IC50 of 300 nM. KU-58050 does not prevent the ATM-dependent phosphorylation of p53 serine 15 until a dose of 30 μM. Addition of KU-55933 has no appreciable effects on UV-induced phosphorylation of H2AX on serine 139, NBS1 on serine 343, CHK1 on serine 345, and SMC1 on serine 966. In stark contrast to the UV responses, KU-55933 ablates the ionizing radiation-induced phosphorylation of these ATM substrates. KU-55933 sensitizes HeLa cells to a range of ionizing radiation doses. ^[1] KU-55933 inhibits the phosphorylation of Akt induced by growth factors in cancer cells. KU-55933 suppresses the proliferation of cancer cells. Furthermore, suppression of ATM by KU-55933 improves survival, probably via prevention of downstream activation of TAp63α. ^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
DU-145	NF\1RVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LTNGlEPTB;Mz6yO\|M2OiEQvF2=	NInVW3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
HuO-3N1	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3noUmlEPTB;ND6xO\|E1OiEQvF2=	MlTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
LAMA-84	NXfqRoVwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkTJTWM2OD12LkW4OFY2KM7:TR?=	NFjxe\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
CAL-72	NEHGS\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NULCcYlLUUN3ME21MlQ5ODh2IN88US=>	NFHueWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
LoVo	NV[yXFlwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVr0R2VnUUN3ME22Mlk{OjN7IN88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HH	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV7EXIM5UUN3ME24MlI4PjdzIN88US=>	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-MEL-3	NIC0S4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3HoTmlEPTB;OD6yPFU4PSEQvF2=	NWrVfoRwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
KM12	MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWfkdIJ3UUN3ME25MlIyOTR{IN88US=>	Mk\lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1437	NVLtOJlNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWXBV5JyUUN3ME25MlgxQTdizszN	NEj5ZYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
NCI-H1838	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlfETWM2OD1zMT6xPFY2KM7:TR?=	NIPS[nE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
J-RT3-T3-5	NIn5bXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUfw[YZjUUN3ME2xNU4zPDF5IN88US=>	MnroQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
GOTO	NVfuZ3I1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2PGeWlEPTB;MUGuOlk6PiEQvF2=	NHjENWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
LB2241-RCC	NGH3c49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkflTWM2OD1zMT63NVg3KM7:TR?=	NF7oOnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
ES7	NGHCPXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWnJR\|UxRTFzLke4PEDPxE1?	M{jXd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KP-N-YS	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRTF{Lk[zOVQh\|ryP	MmnzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
CAL-12T	MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{PiOmlEPTB;MUOuOlE4KM7:TR?=	M{XsT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
COLO-684	Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlvtTWM2OD1zND6xOVY6KM7:TR?=	MonUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
DOK	NGXlNYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2L6fmlEPTB;MUWuN\|MzQSEQvF2=	M13tWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
Hs-578-T	NILTS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2XHbmlEPTB;MUWuOFE5OiEQvF2=	M2nFclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
D-423MG	NV7JZYwyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3vGNmlEPTB;MUWuOVI{PiEQvF2=	M3OwWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
DBTRG-05MG	MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYnJR\|UxRTF3Lk[xNVEh\|ryP	M4X1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
VM-CUB-1	MlzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIOzOoVKSzVyPUG1Mlk5PDlizszN	M1:2WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
KG-1	NXrFenRMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml;1TWM2OD1zNj6wPVk3KM7:TR?=	NV3oNnRjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
8305C	M3y5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmTuTWM2OD1zNj6xPFg6KM7:TR?=	M37ER\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HuH-7	MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml\GTWM2OD1zNj6yOlc1KM7:TR?=	M4qxUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
LXF-289	NULaNWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3TpW2lEPTB;MU[uNlc1PyEQvF2=	Mk[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-H1793	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3nvZ2lEPTB;MU[uOFcyOiEQvF2=	NYH0UGJtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
ChaGo-K-1	NYjTNGdTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX\JR\|UxRTF4Lk[1Olgh\|ryP	NGf2eGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
GCIY	M{HP[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTF4Lke5NFUh\|ryP	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
SK-MEL-28	M2rBWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXfJR\|UxRTF5LkC0O\|Uh\|ryP	MnvpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
NCI-SNU-1	M4PBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{PSO2lEPTB;MUeuNVI3QSEQvF2=	NYHLUYdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
CTB-1	M{jLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2S0SWlEPTB;MUeuNlI2QSEQvF2=	NX7DUokzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
NCI-H82	NGDUPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mmr4TWM2OD1zNz60OVc{KM7:TR?=	M1XTWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
HCC2998	MlSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoXqTWM2OD1zNz62O\|M{KM7:TR?=	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
NCI-H2030	MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHHuXY9KSzVyPUG4MlE6QTdizszN	MlfVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
HuP-T3	MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXXRc\|V7UUN3ME2xPE42QDh6IN88US=>	M1rv[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFIzOjFyMj:nQnNCVkeHUkyvZV4>
697	MlnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUPJR\|UxRTF7LkCyNFEh\|ryP	NHXkSmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
MLMA	NHfBSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIe0[VRKSzVyPUG5MlA2PTdizszN	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
HCC70	M3f2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NILub\|VKSzVyPUG5MlQ5QSEQvF2=	MkWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
A704	NFLsUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEn4N29KSzVyPUG5Mlg{ODVizszN	NE\HU489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
D-283MED	NVLYcXRbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWfJR\|UxRTJyLkWzN\|kh\|ryP	NX\kU3BoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
U031	M373PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVjsZpRlUUN3ME2yNU4yPDh7IN88US=>	NX61NpdvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
HSC-3	NIL6XXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXnJR\|UxRTJzLkG4N\|Uh\|ryP	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNlIyODJxJ{7TRW5ITVJ:L3G+
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KARPAS-299	NVPGSGIyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXP5T4t{UUN3ME20Ok4{PTF4IN88US=>	NX\LNo5DRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
RS4-11	Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\zUmlEPTB;NE[uOVQzKM7:TR?=	NFzvPVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwzOjJzMEKvK\|5USU6JRWK8M4E,
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EPLC-272H	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWm2bIJRUUN3ME20Ok46PTB\|IN88US=>	NWDST4xjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
BALL-1	M{TXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUPJR\|UxRTR5LkizNkDPxE1?	NYTzeo9kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOjJ{MUCyM{c,W0GQR1XSQE9iRg>?
LCLC-97TM1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1XNVGlEPTB;NEiuNlAzKM7:TR?=	Mo\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNlIzOTB{Lze+V2FPT0WUPD;hQi=>
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HepG2	MmHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NYfQ[lQ6OTEEoN88US=>	NVzSdIpHOjRiaB?=		M3fFZYJtd2OtczDTR{1KUUl\|LXnu[JVk\WRiUzDwbIF{\SCjcoLld5Q>	MlPRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkexNlMoRjJ3NUK3NVI{RC:jPh?=
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IMR-32	MXPGeY5kfGmxbjDBd5NigQ>?	MW[xNOKh\|ryPwrC=	NYDxNHczOjRiaB?=		MXXpcohq[mm2czDjcIlweXWrbn;sMYlv\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJJA2Ow>?	NEnQNVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[yO\|I6PCd-MkK2NlczQTR:L3G+
A549	MW\GeY5kfGmxbjDBd5NigQ>?	MVOxNOKh\|ryPwrC=	NUPSVWw2OSCq		NX\vNmh3e3WycILld5NmeyCQYX7vMWNwNWmwZIXj[YQheDV\|IHHjZ5VufWyjdHnvci=>	M1yzdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUW5N\|IyLz5{MkW1PVMzOTxxYU6=
T47D	MkfRSpVv[3Srb36gRZN{[Xl?	M1zHXFIxyqCvTR?=	NWfoWHBrOjRiaB?=	MlXGSG1UVw>?	NIjQRVhxemW4ZX70d{BKWi2rbnT1Z4VlKGSnZ4Lh[IF1cW:wIH;mJGnPwkMQsR?=	NUfNbYZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGxOFQ5ODVpPkKxNVQ1QDB3PD;hQi=>
A29 MEF	MWXGeY5kfGmxbjDBd5NigQ>?	MXSxNOKh\|ryPwrC=	MkTyNYg>		MVHicI9kc3QEoITo[UBxcG:\|cHjvdplt[XSrb36gc4YhSWu2IHH0JHNmejR5M9Mg	M2rtRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMEWzO\|gyLz5{MEC1N\|c5OTxxYU6=
MDA-MB-453	M4\rPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWDtR3B{PS12MDFOwG0>	M3X3SFczKGh?		MlPoTWM2OCCxZjCxNEDPxE1?	MmD6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjByNUO3PFEoRjJyMEWzO\|gyRC:jPh?=
PC-3	NFzHS4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHXRRVM2NTRyIN88US=>	M1jEcFczKGh?		NX;qWJFiUUN3MDDv[kAyOCEQvF2=	NXzIbpNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCwOVM4QDFpPkKwNFU{PzhzPD;hQi=>
U2OS	MUXGeY5kfGmxbjDhd5NigQ>?				MljTTY5pcWKrdHnvckBw\iCDVF2gbY4hcHWvYX6gWVJQWyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJA2OyCyaH;zdIhwenmuYYTpc44h[XRiU3XyNVUhemW\|aXT1[UwhUUN3MDC9JFAvOjVizszNMi=>	M{fqUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOyPVY2Lz5{Nk[zNlk3PTxxYU6=
MCF7	Mni2SpVv[3Srb36gZZN{[Xl?		MXuxJIhz		M4PQ[2lvcGmkaYTpc44hd2ZiQWTNJItqdmG\|ZTDpckBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEGgbJIh[nliaX3teY5w\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwJF0hOC5\|IN88UU4>	NGm1eW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNlk3PSd-Mk[2N\|I6PjV:L3G+
BJ	MUPGeY5kfGmxbjDhd5NigQ>?	MmD1NVAhfU1?	M1ruPFExKGSjeYO=		M2\oZ3N2eHC{ZYPzbY9vKG:oIIPlcoV{[2WwY3WgbY4hcHWvYX6gRmoh[2WubIOgZZN{\XO\|ZXSgZZMhcW6lcnXhd4UhcW5iY3XscEBvfW2kZYKgZZQhOTBidV2gZYZ1\XJiMUCg[IF6eyCkeTDz[Y5me2OnbnPlJJJmfmW{c3HsJIF{e2G7	MlLoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ5NkewPFUoRjF4N{[3NFg2RC:jPh?=
BJ	NV;ON3hXTnWwY4Tpc44h[XO\|YYm=	MYCxNEB2VQ>?	M4Toe\|ExKGSjeYO=		MYDJcohq[mm2aX;uJI9nKGG2YYjpZUB1\Wyjbnfp[YN1[XOrYT3teZRifGWmIHnuJIh2dWGwIFLKJINmdGy\|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOnbHygcpVu[mW{IHH0JFExKHWPIHHmeIVzKDFyIHThfZMh[nlic3Xu[ZNk\W6lZTDy[ZZmenOjbDDhd5NigQ>?	NX7jSYdtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3OlcxQDVpPkG2O\|Y4ODh3PD;hQi=>
MCF7	NF;V[GFHfW6ldHnvckBie3OjeR?=	MmHYNVAhfU1?	Mm\kNVAhdWmwcx?=		MV3T[Y5{cXSrenH0bY9vKG:oIHnu[pJiemWmLXnu[JVk\WRiRF7BJIRidWGpZTDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W\|c3XkJIF{KHKnZIXjeIlwdiCrbjDjc4xwdnliZn;ycYF1cW:wIHH0JFExKHWPIIDy[ZRz\WG2ZXSg[o9zKDFyIH3pcpMh\m:ubH;3[YQh[nliaYLyZYRq[XSrb36g[o9zKDRiaILzJI1m[XO3cnXkJIFnfGW{IEGwJIRigXNiYomgZ5J6e3SjbDD2bY9t\XRic4ThbY5qdmdiYX7hcJl{cXN?	NYX6W2FCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N\|I6PjVpPkK2OlMzQTZ3PD;hQi=>
SK-N-MC	M2fmUpFJXFNiYYPzZZk>				NWnIdm1LeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC\|Y4Ll[Y4h\m:{IGPLMW4uVUNiY3XscJM>	NUK5T4M6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N\|UyOzlpPkK5OFM2OTN7PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-AKT(Ser473) / p-AKT(Thr308); PubMed: 22739265 Chin J Cancer Cells were serum-starved for 6 h and treated with KU-55933 (10 µmol/L) for 1 h before treatment with insulin (100 nmol/L) for 45 min. Cells were lysed, and cell lysates were subjected to SDS-PAGE and Western blotting for the detection of phospho-Akt at Se䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖 PARP / Cleaved PARP / Caspase-3 / Cleaved caspase-3 ; PubMed: 22739265 Chin J Cancer ATM inhibition by KU-55933 induces apoptosis in differentiated but not undifferentiated SH-SY5Y cells. Cells were starved for 6 h in serum-free medium. KU-55933 (10 µmol/L) was added 1 h before insulin (100 nmol/L) treatment. After 3 h of insulin stimulat䲧疝Ỵ疞㧀疜膉痘 瘿�෋ᾰƌ෋à 㺣痖帉痖Ѐ瑖堘𢡄빢᎒෋à鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤 ATM-S1981 / ATM / p-p53(S15) / p53 ; PubMed: 20639198 J Biol Chem Antioxidant and ATM inhibitors blocked phosphorylation of ATM-S1981, Akt-S473, and p53-S15 as stimulated by H2O2 exposure. Cells were treated with 100 μm H2O2 for 30 min in the absence or presence of KU-55933. Whole cell lysates were subjected to Western 䲧疝Ỵ疞㧀疜膉痘 瘿뾠ՂᾰƌՂĀ 㺣痖 p21 / p27 / p53 ; PubMed: 20177072 J Biol Chem HMGE cells were incubated for the indicated times with 1 μm KU-55933 or DMSO. Total protein extracts were analyzed by Western blotting for p21WAF1/CIP1, p27KIP1, p53, or β-actin.	22739265 20639198 20177072
Immunofluorescence	p-S824 KAP1 / ZEBRA ; PubMed: 28249048 PLoS Pathog HH514-16 cells were treated with NaB (upper panel) or NaB plus KU-55933 (1μM; middle panel) or NaB plus Torin1 (0.5μM; lower panel) for 24 hours and stained with anti-phospho KAP1 (S824) plus anti-ZEBRA antibodies and visualized at 1000X magnification.	28249048

In vivo

Suppression of ATM-dependent STAT3 activation by KU-55933 enhances TRAIL-mediated apoptosis through up-regulation of surface DR5 expression, whereas suppression of both STAT3 and NF-κB appeares to be involved in down-regulation of cFLIP accompanied by an additional increase in apoptotic levels. The ATM inhibitor KU-55933 affectes TRAIL-mediated apoptosis more strongly than the JAK2 inhibitor, AG490, or overexpression of STAT3β. ^[3]

Protocol

Kinase Assay: ^[1]	- Collapse Purified enzyme assays: ATM for use in the in vitro assay is obtained from HeLa nuclear extract by immunoprecipitation with rabbit polyclonal antiserum raised to the COOH-terminal 400 amino acids of ATM in buffer containing 25 mM HEPES (pH 7.4), 2 mM MgCl₂, 250 mM KCl, 500 μM EDTA, 100 μM Na₃VO₄, 10% v/v glycerol, and 0.1% v/v Igepal. ATM-antibody complexes are isolated from nuclear extract by incubating with protein A-Sepharose beads for 1 hour and then through centrifugation to recover the beads. In the well of a 96-well plate, ATM-containing Sepharose beads are incubated with 1 μg of substrate glutathione S-transferase–p53N66 (NH₂-terminal 66 amino acids of p53 fused to glutathione S-transferase) in ATM assay buffer [25 mM HEPES (pH 7.4), 75 mM NaCl, 3 mM MgCl₂, 2 mM MnCl₂, 50 μM Na₃VO₄, 500 μM DTT, and 5% v/v glycerol] at 37 °C in the presence or absence of inhibitor. After 10 minutes with gentle shaking, ATP is added to a final concentration of 50 μM and the reaction continued at 37 °C for an additional 1 hour. The plate is centrifuged at 250 × g for 10 minutes (4 °C) to remove the ATM-containing beads, and the supernatant is removed and transferred to a white opaque 96-well plate and incubated at room temperature for 1.5 hours to allow glutathione S-transferase-p53N66 binding. This plate is then washed with PBS, blotted dry, and analyzed by a standard ELISA technique with a phospho-serine 15 p53 antibody. The detection of phosphorylated glutathione S-transferase-p53N66 substrate is performed in combination with a goat antimouse horseradish peroxidase-conjugated secondary antibody. Enhanced chemiluminescence solution is used to produce a signal and chemiluminescent detection is carried out.
Cell Research: ^[1]	- Collapse Cell lines: U2OS cells Concentrations: 10 μM Incubation Time: 2 hours Method: U2OS cells are exposed to ionizing radiation (3, 5, or 15 Gy) or UV (5 or 50 J/m²) and the ATM response determined by Western blot analysis of p53 serine 15 phosphorylation and stabilization of wild-type p53. Whole cell extracts are obtained from each time point, proteins separated by SDS-PAGE, and the ATM-specific increase in phosphorylated serine 15 measured with a p53 phospho-serine 15 specific antibody. Overall p53 stabilization with time is also observed with a p53-specific antibody (DO-1). Similarly, for studying ATM-dependent phosphorylations on H2AX, CHK1, NBS1, and SMC1, the following antibodies are used: CHK1 phospho-serine 345 and NBS1 phospho-serine 343 antibodies. Histone H2A (H-124) and CHK1 antibodies are also used, as well as SMC1 and SMC1 phospho-serine 966 antibodies. For determination of a cellular IC50 for KU-55933, the peak response time for p53 serine 15 phosphorylation of 2 hours is used to monitor inhibition of ATM. KU-55933 is titrated onto cells and preincubated for 1 hour before ionizing radiation. Using scanning densitometry, the percentage inhibition relative to vehicle control is calculated, and the IC50 value is calculated as for the in vitro determinations. (Only for Reference)
Animal Research: ^[3]	- Collapse Animal Models: BALB/c nu/nu nude mice bearing LU1205 cells Dosages: 10 μM Administration: -- (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	33 mg/mL (83.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5%DMSO+40%PEG300+5%Tween80+50%ddH2O For best results, use promptly after mixing.	3.95 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download KU-55933 (ATM Kinase Inhibitor) SDF

Molecular Weight	395.49
Formula	C₂₁H₁₇NO₃S₂
CAS No.	587871-26-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

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KU-55933 (ATM Kinase Inhibitor)