Niclosamide

Catalog No.S3030 Synonyms: Niclocide

Niclosamide Chemical Structure

Molecular Weight(MW): 327.12

Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).

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  • Bacterial infection in IPEC-J2 cells. The invasion and attachment of EHECO157:H7 was increased in the IPEC-J2 cells in the presence of 1 μM niclosamide. Data are expressed as the mean ± SEM (n= 6). Differences between groups were determined by paired samples t-test. *P<0.05 compared with the control.

    Int Immunopharmacol, 2016, 36:199-204.. Niclosamide purchased from Selleck.

    Inhibition of STAT3 phosphorylation by niclosamide in colon cancer cells HCT116 and SW620. Notes: (A) SW620 cells were treated with niclosamide (5 µM) for different lengths of time (0, 2, 4, 6, 8, and 12 h). Total protein was extracted, and the expression levels of P-STAT3, STAT3, and GAPDH proteins were detected by Western blot analysis. (B) HCT116 cells were treated with niclosamide (5 µM) for different lengths of time (0, 2, 4, 6, 8, and 12 h). Total protein was extracted, and the expression levels of P-STAT3, STAT3, and GAPDH proteins were detected by Western blot analysis. (C) SW620 cells were treated with niclosamide at different concentrations (0.5, 1, 2.5, 5, and 10 µM) or vehicle control (DMSO) for 12 h. (D) HCT116 cells were treated with niclosamide at different concentrations (0.5, 1, 2.5, 5, and 10 µM) or vehicle control (DMSO) for 12 h. Total protein was then extracted and detected by Western blot analysis. The data were obtained from 3 independent experiments. *P<0.05.

    Onco Targets Ther, 2017, 10:1767-1776. Niclosamide purchased from Selleck.

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Choose Selective STAT Inhibitors

Biological Activity

Description Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
Targets
STAT3 [1]
(in Hela cells)
0.7 μM
In vitro

Niclosamide (< 5 μM) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 μM in HeLa cells. Niclosamide(< 2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide(< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide(< 10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells. [1] Niclosamide is able to inhibit SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV. [2] Niclosamide(< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells. [3] Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide(125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide(< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB–DNA complex in HL-60 cells. Niclosamide(< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide(500 nM) decreases TNF-induced NF-κB–dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Vero E6 cells MVXGeY5kfGmxbjDhd5NigQ>? M33heGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHNCWlNiY3;yc45ifmm{dYOgbY4hXmW{bzDFOkBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHL5JGVNUVODLDDFR|UxRTBwMTFOwG0> NVnkOXhDOTd4NkO1N|k>
human blood cancer cells M1PRVGN6fG:2b4jpZ:Kh[XO|YYm= MmnVO|IhcA>? M4PXN2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJIJtd2:mIHPhcoNmeiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubDDUbZRmeiCJbH:gRZN{[XluIFnDOVA:OC5zMzFOwG0> NGr0clAzPjJ5MkCzNi=>
human pancreatic cancer cells MYLDfZRwfG:6aXRCpIF{e2G7 NX3PNWhqPzJiaB?= M{HwNGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJJBidmO{ZXH0bYMh[2GwY3XyJINmdGy|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtKFSrdHXyJGdtdyCDc4PhfUwhUUN3ME2wMlE{KM7:TR?= M2jrV|I3Ojd{MEOy
human ovarian cancer cells Mlm0R5l1d3SxeHnjxsBie3OjeR?= NV7SRmdHPzJiaB?= MoDZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gc5ZiemmjbjDjZY5k\XJiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHygWIl1\XJiR3zvJGF{e2G7LDDJR|UxRTBwMUOg{txO MV6yOlI4OjB|Mh?=
human lung cancer cells NGXlT3NEgXSxdH;4bYPDqGG|c3H5 MX23NkBp NFvNTGNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBtfW6pIHPhcoNmeiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubDDUbZRmeiCJbH:gRZN{[XluIFnDOVA:OC5zMzFOwG0> NVqwT|hkOjZ{N{KwN|I>
human colon cancer cells Mlv6R5l1d3SxeHnjxsBie3OjeR?= MVi3NkBp MnPiR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZ49td25iY3HuZ4VzKGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBE\WyuIGTpeIVzKEeubzDBd5NigSxiSVO1NF0xNjF|IN88US=> NYXEeYI3OjZ{N{KwN|I>
human prostate cancer cells NULwb|ZpS3m2b4TvfIlkyqCjc4PhfS=> MX23NkBp MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwdo9{fGG2ZTDjZY5k\XJiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHygWIl1\XJiR3zvJGF{e2G7LDDJR|UxRTBwMUOg{txO MXSyOlI4OjB|Mh?=
human breast cancer cells NYrSdoRUS3m2b4TvfIlkyqCjc4PhfS=> MWW3NkBp Ml\6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gZpJm[XO2IHPhcoNmeiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubDDUbZRmeiCJbH:gRZN{[XluIFnDOVA:OC5zMzFOwG0> NUewRm1lOjZ{N{KwN|I>
human HeLa cells MoHtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGHDeHozPCCq M2T5RmlvcGmkaYTpc44hd2ZiU2TBWFMhcW5iaIXtZY4hUGWOYTDj[YxteyCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMkWg{txO NY\qSo95OjR7MECyN|E>
HEK293 cells MV3GeY5kfGmxbjDhd5NigQ>? NHnZVWc5KGh? NFnzOZpKdmirYnn0bY9vKG:oIGfueE9j\XSjLXPheIVvcW5iaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhX262M1Gtd5RqdXWuYYTl[EBVV1CIbHHzbEBi[3Srdnn0fUBi\nSncjC4JIhzeyxiSVO1NF0xNjN2IN88US=> MXeyOlI4OjB|Mh?=
human PC3 cells MnXPVJJwdGmoZYLheIlwdiCjc4PhfS=> Mn;ONVIxKGh? MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjZoTldkAyOjBiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjRizszN MkXmNVY3QDBzNUm=
HEK293 cells MVrGeY5kfGmxbjDhd5NigQ>? NVvYN4MyQCCq NETZdnhKdmirYnn0bY9vKG:oIGfueFNCN2KndHGtZ4F{\WmwIIPp[45idGmwZzDpckBJTUt{OUOgZ4VtdHNiYX\0[ZIhQCCqcoOgZpkhXE:SZnzhd4ghemWyb4L0[ZIh[XO|YYmsJGlEPTB;MD60JO69VQ>? NF\FUW8zOzR3M{C3Ny=>
human A549 cells M4HpVXBzd2yrZnXyZZRqd25iYYPzZZk> NYLUfppmOTJyIHi= MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiYX\0[ZIhOTJyIHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC52IN88US=> MkTBNVY3QDBzNUm=
human U87MG cells M2HOZnBzd2yrZnXyZZRqd25iYYPzZZk> Mn\yNVIxKGh? MoLDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOEfNS{Bk\WyuczDh[pRmeiBzMkCgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkSg{txO NFHiUpIyPjZ6MEG1PS=>
human HCT116 cells NYexRpRkS3m2b4TvfIlkyqCjc4PhfS=> NHLpdVA4OiCq M4i1fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7LDDJR|UxRTBwNEWg{txO NXvNU|dDOjZ{N{KwN|I>
human DU145 cells M2jGfXBzd2yrZnXyZZRqd25iYYPzZZk> NFPJdWM4OiCq NEDP[lNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFTVNVQ2KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD63JO69VQ>? NHf6dFIzPDlyMEKzNS=>
human LoVo cells NEPl[2pRem:uaX\ldoF1cW:wIHHzd4F6 M4jHWVEzOCCq Mm\WRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCOb2\vJINmdGy|IHHmeIVzKDF{MDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNzFOwG0> NIW1WWMyPjZ6MEG1PS=>
human MCF7 cells M1y3OmN6fG:2b4jpZ:Kh[XO|YYm= M{X4VWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KEWULYDvd4l1cX[nIHj1cYFvKE2FRkegZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyIE2xMlA3KM7:TR?= MWKyN|QyPjF7MR?=
human MIAPaCa2 cells M1HQfnBzd2yrZnXyZZRqd25iYYPzZZk> MUWxNlAhcA>? M2TKVWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVnBVIFE[TJiY3XscJMh[W[2ZYKgNVIxKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NU4yKM7:TR?= NILNbJkyPjZ6MEG1PS=>
MDA-MB-231 cells NXH5cYNlS3m2b4TvfIlkyqCjc4PhfS=> Mn[2O|IhcA>? Mk\SR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSXIhdmWpYYTpeoUhVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUCuO|kh|ryP NIC0VpYzOzR3OU[xNy=>
human HeLa cells MkHyVJJwdGmoZYLheIlwdiCjc4PhfS=> NEC0PFA4OiCq NGjzO21CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjlUIEh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zLkSg{txO NIn4cIMzPDlyMEKzNS=>
human AsPC1 cells NF7zSZREgXSxdH;4bYPDqGG|c3H5 Ml3vO|IhcA>? M4njR2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF{WENzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9NU41PyEQvF2= MV6yN|Q2QTZzMx?=
human PANC1 cells MUTDfZRwfG:6aXRCpIF{e2G7 NXLBe5hnPzJiaB?= MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQRW5EOSClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRUKGG|c3H5MEBKSzVyPUGuO|Mh|ryP NET3WXQzOzR3OU[xNy=>
human A549 cells  MUHQdo9tcW[ncnH0bY9vKGG|c3H5 M1;zdlczKGh? MkDPRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OyEQvF2= NULRbo01OjR7MECyN|E>
human HT-29 cells M2THVHBzd2yrZnXyZZRqd25iYYPzZZk> MWC3NkBp NFL4PZlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Nz6yJO69VQ>? NV\aRYRVOjR7MECyN|E>
human A431 cells NHywd29Rem:uaX\ldoF1cW:wIHHzd4F6 NW\HVYc1PzJiaB?= MU\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF2M{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF05NjhizszN M2ridFI1QTByMkOx
human Ava5 cells MX;DfZRwfG:6aXRCpIF{e2G7 NEjuVGw{KGSjeYO= M4q0SmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF3[TViY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JI5mfXS{YXygdoVlKGS7ZTDhd5NigSxiQ1O1NF0yOCEQvF2= NVGxSpQ5OjJyNUm5PFM>
human PC3 cells NIH6V41Rem:uaX\ldoF1cW:wIHHzd4F6 M4PMVFczKGh? MnXGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOS55IN88US=> M3zwe|I1QTByMkOx
mouse RAW264.7 cells MUPGeY5kfGmxbjDhd5NigQ>? NXTFTFJCOTBizszN NHjOc2FEgXSxcILveIVkfGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHHueIhz[XhidH;4bY4hdGW2aHHsJIZi[3Sxcj;wdo91\WO2aY\lJIFvfGmpZX6tbY5lfWOnZDDj[YxtKGSnYYToJIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHH0JFExKHWPIHL5JG1VXCC{ZXT1Z5Rqd25iYYPzZZk> MmjFNVk2PDB5NkS=
CHO cells MkjwSpVv[3Srb36gZZN{[Xl? NYK1fHpmS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDhcpRpemG6IH\1d4lwdiC2b4jpckBHWDV7LXnu[JVk\WRiY3XscEBl\WG2aDDpckBEUE9iY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[nliTWTUJJJm\HWldHnvckBie3OjeR?= MoPzNVk2PDB5NkS=
human HeLa cells NILCW2dHfW6ldHnvckBie3OjeR?= MVK1JO69VQ>? NUO3dplwOjRiaB?= M1;nc2lvcGmkaYTpc44hd2ZiU2TBWFMhcW5iaIXtZY4hUGWOYTDj[YxteyCjdDC1JJVOKGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? MoDpNlQ6ODB{M{G=
human U2OS cells NF7xeZlHfW6ldHnvckBie3OjeR?= M4fDXlEzNjVizszN MlnnOkBp MUjJcoR2[3Srb36gc4YhcW62ZYLuZYxqgmG2aX;uJI9nKE[{aYr6cIVlOS2JRmCgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hcHWvYX6gWVJQWyClZXzsd{BifCBzMj61JJVOKGGodHXyJFYhcHK|IHL5JINwdm[xY3HsJI1q[3Kxc3PvdJk> NXHTW3NXOjN2NUOwO|M>

... Click to View More Cell Line Experimental Data

In vivo Niclosamide(40 mg/kg/d, i.p.) inhibits growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors. [4]

Protocol

Kinase Assay:

[1]

+ Expand

Protein Kinase profiling assay:

Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.
Cell Research:

[1]

+ Expand
  • Cell lines: Hela, A549, Du145, HT-29, A431, PC3 cells
  • Concentrations: 16 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are plated in 96-well culture plates with cell density of 3-4 × 103 cells/well and treat with Niclosamide by adding 100 μL medium containing Niclosamide of various concentrations on the second day. After 72-hour's treatment, MTT is added to each well and incubated for additional 4-5 hours, and the absorbance is measured on a microplate reader at 570nm. Cell growth inhibition is evaluated as the ratio of the absorbance of the sample to that of the control. The results are representative of at least 3 independent experiments.


    (Only for Reference)
Animal Research:

[4]

+ Expand
  • Animal Models: nude mice bearing HL-60 xenograft tumors.
  • Formulation: DMSO
  • Dosages: 40 mg/kg
  • Administration: Intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro DMF 12 mg/mL warmed (36.68 mM)
DMSO Insoluble
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
1% DMSO+30% polyethylene glycol+1% Tween 80
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 327.12
Formula

C13H8Cl2N2O4

CAS No. 50-65-7
Storage powder
in solvent
Synonyms Niclocide

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03123978 Recruiting Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer University of California Davis|National Cancer Institute (NCI)|Pandomedx January 9 2017 Phase 1
NCT02687009 Recruiting Colon Cancer Michael Morse MD|Duke University November 7 2017 Phase 1
NCT02532114 Completed Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Adenocarcinoma University of Washington|National Cancer Institute (NCI) December 31 2015 Phase 1
NCT02807805 Recruiting Metastatic Prostate Carcinoma|Recurrent Prostate Carcinoma|Stage IV Prostate Cancer Chong-xian Pan|National Cancer Institute (NCI)|University of California Davis September 2016 Phase 2
NCT02519582 Recruiting Colorectal Cancer Charite University Berlin Germany|Center for Molecular Medicine August 2015 Phase 2
NCT03521232 Recruiting Ulcerative Colitis|Ulcerative Proctitis|Ulcerative Proctosigmoiditis First Wave Bio Inc. May 15 2018 Phase 1|Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID