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Niclosamide

For research use only.

Catalog No.S3030 Synonyms: Niclocide

26 publications

Niclosamide Chemical Structure

CAS No. 50-65-7

Niclosamide (Niclocide) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).

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Selleck's Niclosamide has been cited by 26 publications

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Choose Selective STAT Inhibitors

Biological Activity

Description Niclosamide (Niclocide) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
Targets
STAT3 [1]
(in Hela cells)
0.7 μM
In vitro

Niclosamide (< 5 μM) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 μM in HeLa cells. Niclosamide(< 2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide(< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide(< 10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells. [1] Niclosamide is able to inhibit SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV. [2] Niclosamide(< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells. [3] Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide(125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide(< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB–DNA complex in HL-60 cells. Niclosamide(< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide(500 nM) decreases TNF-induced NF-κB–dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Vero E6 cells MkPSSpVv[3Srb36gZZN{[Xl? NIrnN2lCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBUSVKVIHPvdo9v[X[rcoXzJIlvKF[ncn:gSVYh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDifUBGVEmVQTygSWM2OD1yLkGg{txO Mo\0NVc3PjN3M{m=
human blood cancer cells M3fiRmN6fG:2b4jpZ:Kh[XO|YYm= MmfxO|IhcA>? MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDicI9w\CClYX7j[ZIh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGxiVHn0[ZIhT2yxIFHzd4F6NCCLQ{WwQVAvOTNizszN NVPPSYRiOjZ{N{KwN|I>
human pancreatic cancer cells NHPkSpFEgXSxdH;4bYPDqGG|c3H5 M3r0WFczKGh? MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDwZY5kemWjdHnjJINidmOncjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscEBVcXSncjDHcI8hSXO|YYmsJGlEPTB;MD6xN{DPxE1? NYDiOY9{OjZ{N{KwN|I>
human ovarian cancer cells MYnDfZRwfG:6aXRCpIF{e2G7 NYH5dJk3PzJiaB?= NFvTNY9EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBwfmG{aXHuJINidmOncjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscEBVcXSncjDHcI8hSXO|YYmsJGlEPTB;MD6xN{DPxE1? M4jrdlI3Ojd{MEOy
human lung cancer cells M3rqUWN6fG:2b4jpZ:Kh[XO|YYm= MUG3NkBp Mn2yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gcJVv\yClYX7j[ZIh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JGNmdGxiVHn0[ZIhT2yxIFHzd4F6NCCLQ{WwQVAvOTNizszN MoTxNlYzPzJyM{K=
human colon cancer cells NXm3S|Y6S3m2b4TvfIlkyqCjc4PhfS=> NETFTWk4OiCq M2jSUmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJINwdG:wIHPhcoNmeiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkhS2WubDDUbZRmeiCJbH:gRZN{[XluIFnDOVA:OC5zMzFOwG0> Ml;WNlYzPzJyM{K=
human prostate cancer cells MoXOR5l1d3SxeHnjxsBie3OjeR?= MmHsO|IhcA>? MmfwR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gdJJwe3SjdHWgZ4Fv[2W{IHPlcIx{KGG|c3Xzd4VlKGG|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsJHRqfGW{IFfsc{BCe3OjeTygTWM2OD1yLkGzJO69VQ>? MYOyOlI4OjB|Mh?=
human breast cancer cells M1mxTWN6fG:2b4jpZ:Kh[XO|YYm= NV:zfJZZPzJiaB?= NYn1VZp3S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4h[nKnYYP0JINidmOncjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscEBVcXSncjDHcI8hSXO|YYmsJGlEPTB;MD6xN{DPxE1? MUWyOlI4OjB|Mh?=
human HeLa cells NEPXW4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIOzZokzPCCq NE\hb2lKdmirYnn0bY9vKG:oIGPURXQ{KGmwIHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1yLkK1JO69VQ>? NUHwc3YyOjR7MECyN|E>
HEK293 cells NV22N25RTnWwY4Tpc44h[XO|YYm= NHjpPYk5KGh? M3j6PGlvcGmkaYTpc44hd2ZiV370M4JmfGFvY3H0[Y5qdiCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBYdnR|QT3zeIlufWyjdHXkJHRQWE[uYYPoJIFkfGm4aYT5JIFnfGW{IEigbJJ{NCCLQ{WwQVAvOzRizszN NYLKeFdtOjZ{N{KwN|I>
human PC3 cells NGnNNVRRem:uaX\ldoF1cW:wIHHzd4F6 Mn;iNVIxKGh? M3i5WGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDF{MDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNDFOwG0> NUfHcml7OTZ4OECxOVk>
HEK293 cells M3nSRWZ2dmO2aX;uJIF{e2G7 MomzPEBp M{LEV2lvcGmkaYTpc44hd2ZiV370N2Ew[mW2YT3jZZNmcW5ic3nncoFtcW6pIHnuJGhGUzJ7MzDj[YxteyCjZoTldkA5KGi{czDifUBVV1CobHHzbEBz\XCxcoTldkBie3OjeTygTWM2OD1yLkSg{txO MlvNNlM1PTNyN{O=
human A549 cells MkTaVJJwdGmoZYLheIlwdiCjc4PhfS=> NEfyWnYyOjBiaB?= Ml\ZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDF{MDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNDFOwG0> NF;VN2wyPjZ6MEG1PS=>
human U87MG cells NXToV5l{WHKxbHnm[ZJifGmxbjDhd5NigQ>? MVuxNlAhcA>? MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFV6N13HJINmdGy|IHHmeIVzKDF{MDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNDFOwG0> MnXYNVY3QDBzNUm=
human HCT116 cells Mm[0R5l1d3SxeHnjxsBie3OjeR?= NXjjPXNrPzJiaB?= NIrURY5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IF3UV{Bie3OjeTygTWM2OD1yLkS1JO69VQ>? NVG5TZp3OjZ{N{KwN|I>
human DU145 cells M17LWHBzd2yrZnXyZZRqd25iYYPzZZk> Mo\XO|IhcA>? MmPsRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCGVUG0OUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNzFOwG0> MUCyOFkxODJ|MR?=
human LoVo cells NVn1ZVRIWHKxbHnm[ZJifGmxbjDhd5NigQ>? NGfEfGsyOjBiaB?= NFvZZVZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzvWo8h[2WubIOgZYZ1\XJiMUKwJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD63JO69VQ>? MnP0NVY3QDBzNUm=
human MCF7 cells NGD1bnlEgXSxdH;4bYPDqGG|c3H5 NFLhUHdEgXSxdH;4bYNqfHliYXfhbY5{fCCHUj3wc5NqfGm4ZTDoeY1idiCPQ1[3JINmdGy|IHL5JG1VWyCjc4PhfUwhUUN3MDC9NU4xPiEQvF2= NXe1UItHOjN2MU[xPVE>
human MIAPaCa2 cells M{nxcHBzd2yrZnXyZZRqd25iYYPzZZk> NEf2RnAyOjBiaB?= NFHhNXhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3JRXBiS2F{IHPlcIx{KGGodHXyJFEzOCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVEvOSEQvF2= NGfSZ3MyPjZ6MEG1PS=>
MDA-MB-231 cells NWD6cmk2S3m2b4TvfIlkyqCjc4PhfS=> NIfydlM4OiCq M1HvdmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVTKG6nZ3H0bZZmKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlc6KM7:TR?= MlnZNlM1PTl4MUO=
human HeLa cells NH;1RZFRem:uaX\ldoF1cW:wIHHzd4F6 MYe3NkBp M{frTmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXMZUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTFwNDFOwG0> M3rQVFI1QTByMkOx
human AsPC1 cells NEHCfotEgXSxdH;4bYPDqGG|c3H5 NV7CXFgzPzJiaB?= NVy2VXVtS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSXOSQ{GgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WUzDhd5NigSxiSVO1NF0yNjR5IN88US=> MXGyN|Q2QTZzMx?=
human PANC1 cells MUjDfZRwfG:6aXRCpIF{e2G7 MV:3NkBp M1SybWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBCVkNzIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9NU44OyEQvF2= MYWyN|Q2QTZzMx?=
human A549 cells  M{f4SHBzd2yrZnXyZZRqd25iYYPzZZk> NVrvbHRFPzJiaB?= NXTYdVJ7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MzFOwG0> NIDDOmkzPDlyMEKzNS=>
human HT-29 cells MnXJVJJwdGmoZYLheIlwdiCjc4PhfS=> Moj4O|IhcA>? NGPHVmVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUMVI6KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;Nz6yJO69VQ>? NGnINGgzPDlyMEKzNS=>
human A431 cells M{jaNXBzd2yrZnXyZZRqd25iYYPzZZk> MXy3NkBp M{i0RWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRThwODFOwG0> MlnPNlQ6ODB{M{G=
human Ava5 cells MlrtR5l1d3SxeHnjxsBie3OjeR?= NH:wSpU{KGSjeYO= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBeoE2KGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDu[ZV1emGuIILl[EBlgWViYYPzZZktKEOFNUC9NVAh|ryP NHXB[mwzOjB3OUm4Ny=>
human PC3 cells NGfVe3VRem:uaX\ldoF1cW:wIHHzd4F6 NGPkUnE4OiCq NWf4XWxiSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMT63JO69VQ>? MWWyOFkxODJ|MR?=
mouse RAW264.7 cells M1TobWZ2dmO2aX;uJIF{e2G7 M2\i[FExKM7:TR?= NVz5UWFmS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgZYdicW6|dDDhcpRpemG6IITvfIlvKGyndHjhcEBn[WO2b4KvdJJwfGWldHn2[UBidnSrZ3XuMYlv\HWlZXSgZ4VtdCCmZXH0bEBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEAyOCC3TTDifUBOXFRicnXkeYN1cW:wIHHzd4F6 M{n1PVE6PTRyN{[0
CHO cells Mn;KSpVv[3Srb36gZZN{[Xl? M1znUWN6fG:ycn;0[YN1cX[nIHHjeIl3cXS7IHHnZYlve3RiYX70bJJigCCodYPpc44hfG:6aX6gSnA2QS2rbnT1Z4VlKGOnbHyg[IVifGhiaX6gR2hQKGOnbHzzJIF{e2W|c3XkJIF{KGOnbHygeoli[mmuaYT5JIJ6KE2WVDDy[YR2[3Srb36gZZN{[Xl? NVvVbXZsOTl3NEC3OlQ>
human HeLa cells NWPv[5g3TnWwY4Tpc44h[XO|YYm= MnLyOUDPxE1? NEPpcm0zPCCq M3\2VGlvcGmkaYTpc44hd2ZiU2TBWFMhcW5iaIXtZY4hUGWOYTDj[YxteyCjdDC1JJVOKGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? NFjuUY8zPDlyMEKzNS=>
human U2OS cells MWLGeY5kfGmxbjDhd5NigQ>? MX:xNk42KM7:TR?= MVO2JIg> MonLTY5lfWO2aX;uJI9nKGmwdHXycoFtcXqjdHnvckBw\iCIcnn6foxm\DFvR1\QJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKGi3bXHuJHUzV1NiY3XscJMh[XRiMUKuOUB2VSCjZoTldkA3KGi{czDifUBkd26ob3PhcEBucWO{b4Pjc5B6 MkjVNlM1PTNyN{O=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-STAT3 / STAT3 / c-Myc / Survivin ; 

PubMed: 25970160     


LNCaP, C4-2B or DU145 cells were treated with DMSO, 0.5 μM or 1 μM niclosamide overnight, cells were then stimulated with 10 ng/mL of IL6 for 30 minutes. Whole cell lysates were prepared and subjected to Western blot analysis using antibodies as indicated.

p-BCR-ABL / BCR-ABL ; 

PubMed: 29358661     


KBM5 cells harboring wild-type or T315I-BCR-ABL and K562 cell were exposed to different concentrations of niclosamide, and then analyzed by Western blotting analysis.

p-STAT5 / STAT5 / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 29358661     


CML cells were treated with increasing concentrations of niclosamide for 48 h and subjected to Western blotting analysis. Actin served as a loading control for blots above, which were performed sequentially.

β-catenin; 

PubMed: 27652012     


Niclosamide decreases intracellular β-catenin levels in A-498 and SW-839 cells. Cells were treated with niclosamide for 24 h prior to WB analysis.

25970160 29358661 27652012
Growth inhibition assay
Cell viability; 

PubMed: 28418862     


Cell viability of colon cancer cells after treatment of niclosamide for a 48-h period. Cell viability was determined by trypan blue exclusion assay from triplicate experiments.

28418862
In vivo Niclosamide(40 mg/kg/d, i.p.) inhibits growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors. [4]

Protocol

Kinase Assay:

[1]

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Protein Kinase profiling assay:

Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.
Cell Research:

[1]

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  • Cell lines: Hela, A549, Du145, HT-29, A431, PC3 cells
  • Concentrations: 16 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are plated in 96-well culture plates with cell density of 3-4 × 103 cells/well and treat with Niclosamide by adding 100 μL medium containing Niclosamide of various concentrations on the second day. After 72-hour's treatment, MTT is added to each well and incubated for additional 4-5 hours, and the absorbance is measured on a microplate reader at 570nm. Cell growth inhibition is evaluated as the ratio of the absorbance of the sample to that of the control. The results are representative of at least 3 independent experiments.


    (Only for Reference)
Animal Research:

[4]

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  • Animal Models: nude mice bearing HL-60 xenograft tumors.
  • Dosages: 40 mg/kg
  • Administration: Intraperitoneal injection
    (Only for Reference)

Solubility (25°C)

In vitro DMF 12 mg/mL warmed (36.68 mM)
DMSO Insoluble
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 327.12
Formula

C13H8Cl2N2O4

CAS No. 50-65-7
Storage powder
in solvent
Synonyms Niclocide
Smiles C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04436458 Not yet recruiting Drug: Niclosamide Oral Tablet|Drug: Placebo COVID First Wave Bio Inc. December 2020 Phase 2
NCT04644705 Recruiting Drug: Niclosamide|Drug: Placebo Healthy Volunteers Charité Research Organisation GmbH|Bayer November 2 2020 Phase 1
NCT04592835 Not yet recruiting Drug: DWRX2003 COVID-19 Patients Daewoong Pharmaceutical Co. LTD.|Novotech (Australia) Pty Limited October 19 2020 Phase 1
NCT04524052 Not yet recruiting Drug: DWRX2003|Drug: Placebo Healthy Daewoong Pharmaceutical Co. LTD. August 2020 Phase 1
NCT03521232 Recruiting Drug: Niclosamide Ulcerative Colitis|Ulcerative Proctitis|Ulcerative Proctosigmoiditis First Wave Bio Inc. May 15 2018 Phase 1|Phase 2
NCT02687009 Terminated Drug: Niclosamide Colon Cancer Michael Morse MD|Duke University November 7 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID