Home JAK/STAT STAT inhibitor - Autophagy activator Niclosamide (BAY2353)

Niclosamide (BAY2353)

Catalog No.S3030 Synonyms: Niclocide, NSC 178296

For research use only.

Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).

Niclosamide (BAY2353) Chemical Structure

CAS No. 50-65-7

Selleck's Niclosamide (BAY2353) has been cited by 31 publications

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Biological Activity

Description Niclosamide (BAY2353, Niclocide, NSC 178296) can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
Targets
STAT3 [1]
(in Hela cells)
0.7 μM
In vitro

Niclosamide (< 5 μM) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 μM in HeLa cells. Niclosamide(< 2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide(< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide(< 10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells. [1] Niclosamide is able to inhibit SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV. [2] Niclosamide(< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells. [3] Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide(125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide(< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB–DNA complex in HL-60 cells. Niclosamide(< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide(500 nM) decreases TNF-induced NF-κB–dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels. [4]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PC3 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M4PZW|EzOCCqcoO= M2fiXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHmeIVzKDF{MDDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTBwNN88US=> M4T0Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
A549 NEOwU21CdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4P1e|EzOCCqcoO= NYDYdHRtSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEGyNEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOO69VQ>? MmO3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
U87MG NI\NOZdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NUS2fYtCOTJyIHjydy=> NUDsS5VZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDVPFdOTyClZXzsd{Bi\nSncjCxNlAhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlTPxE1? M2TONlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NkiwNVU6Lz5zNk[4NFE2QTxxYU6=
LoVo NXrSXIh1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M4ntcFEzOCCqcoO= M2XiVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTH;Wc{Bk\WyuczDh[pRmeiBzMkCgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkhOwG0> MnHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
MIAPaCa2 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NF7UOlAyOjBiaILz MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2LQWDhR4Ez[2WubIOgZYZ1\XJiMUKwJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT6x{txO MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ6MEG1PUc,OTZ4OECxOVk9N2F-
PC3 NFrnRoJHfW6ldHnvckBie3OjeR?= NY\qdpdIOSCqch?= MojQTY5pcWKrdHnvckBw\iCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJJBwfGWwdHnhcEBqdiCqdX3hckBRSzNiY3XscJMh[W[2ZYKgNUBpeg>? MnLmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
HEK293 MWnGeY5kfGmxbjDhd5NigQ>? M4nCWlEhcHJ? M4rSOWlvcGmkaYTpc44hd2ZibXn0c4Npd26mcnnhcEBu\W2kcnHu[UBxd3SnboTpZYwhcW5iaIXtZY4hUEWNMkmzJINmdGy|IHHmeIVzKDFiaIK= Mlj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
neural precursor NVzpOIhLTnWwY4Tpc44h[XO|YYm= M1XHTWlvcGmkaYTpc44hd2ZibnX1do9{eGincnWgdJJwdGmoZYLheIlwdiCxZjDtc5V{\SCwZYXyZYwheHKnY4Xyd49zKGOnbHzzJIJ6KE2WVDDhd5NigQ>? M1jwb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEG3OlMyLz5zN{SxO|Y{OTxxYU6=
Vero E6 MmfqRY51cX[rcnHsJIF{e2G7 NX[1XJk1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhW0GUUzDjc5JwdmG4aYL1d{BqdiCYZYLvJGU3KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZpkhTUyLU1GsJGVEPTB:MD6x{txO MknVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkO1N|koRjF5Nk[zOVM6RC:jPh?=
Vero E6 M4fadWN6fG:2b4jpZ4l1gSCjc4PhfS=> MnP0R5l1d3SxeHnjbZR6KGGpYXnud5QhXmW{bzDFOkBk\WyuczDifUBOXFRiYYPzZZktKEOFNUC9NlIvOc7:TR?= Ml25QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4NkO1N|koRjF5Nk[zOVM6RC:jPh?=
RAW264.7 MUPDfZRweHKxdHXjeIl3\SCjc4PhfS=> MYixNEB2VQ>? Ml3iR5l1d3C{b4TlZ5RqfmViYXP0bZZqfHliYXfhbY5{fCCjboTodoF5KHSxeHnuJIxmfGijbDDmZYN1d3JxcILveIVkfGm4ZTDhcpRq\2WwLXnu[JVk\WRiY3XscEBl\WG2aDDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjdDCxNEB2VSCkeTDNWHQhemWmdXP0bY9vKGG|c3H5 MkP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3NEC3OlQoRjF7NUSwO|Y1RC:jPh?=
CHO MX7DfZRweHKxdHXjeIl3\SCjc4PhfS=> MkHwR5l1d3C{b4TlZ5RqfmViYXP0bZZqfHliYXfhbY5{fCCjboTodoF5KG[3c3nvckB1d3irbjDGVFU6NWmwZIXj[YQh[2WubDDk[YF1cCCrbjDDTG8h[2WubIOgZZN{\XO|ZXSgZZMh[2WubDD2bYFjcWyrdImgZpkhVVSWIILl[JVkfGmxbjDhd5NigQ>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV2MEe2OEc,OTl3NEC3OlQ9N2F-
CHO NVHMXZlvTnWwY4Tpc44h[XO|YYm= NEfzbpRKdmirYnn0bY9vKG:oIFLhZ4ltdHW|IHHueIhz[WOrczDhcpRpemG6IIDyc5Rm[3SrdnWgZY51cWenbjDo[ZB1[W2ncjDwdoUueG:{ZTD0c{Bxd3KnIHPvcpZmenOrb36gbY4hS02JMj3lfJBz\XO|aX7nJGNJVyClZXzsdy=> NYHn[nZrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm1OFA4PjRpPkG5OVQxPzZ2PD;hQi=>
Ava5 NV7s[pdVSW62aY\pdoFtKGG|c3H5 MYCzJIRigXN? NYTFc5M5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOYIHflco91gXCnIEHiJIlv\mWldHXkJIlvKEG4YUWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA{KGSjeYOgZpkh[myxdDDofYJzcWSrenH0bY9vKGGwYXz5d4l{NCCHQ{WwQVAvOTcQvF2= NYr1U5JYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwOVk6QDNpPkKyNFU6QTh|PD;hQi=>
Ava5 M3vuS2FvfGm4aYLhcEBie3OjeR?= MXSzJIRigXN? NEfKRXdCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJS1ZiZ3Xuc5R6eGViMXKgbY5n\WO2ZXSgbY4hSX[jNTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFMh\GG7czDifUBjdG:2IHj5ZpJq\Gm8YYTpc44h[W6jbInzbZMtKEWFOUC9NE44|ryP M3Hxe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEW5PVg{Lz5{MkC1PVk5OzxxYU6=
Ava5 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NWPVO4RHOyCmYYnz M4TXTmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGF3[TViY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JI5mfXS{YXygdoVlKGS7ZTDhd5NigSxiQ1O1NF0yOM7:TR?= MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB3OUm4N{c,OjJyNUm5PFM9N2F-
HFF MV;BcpRq[XCrY3;tdIxmgGGwIHHzd4F6 MmrDNlQhcHK| MorqRY51cWGyaXPvcZBt\XijbjDhZ5Rqfmm2eTDh[4FqdnO2IGTvfI9xdGG|bXGg[49v\GmrIGLIJJRi[2i7en;peIV{KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{BcO0ifLYXyZYNqdCCrbnPvdpBwemG2aX;uJIFnfGW{IEK0JIhzeyCkeTDzZ4lvfGmubHH0bY9vKGy3bXnu[ZNk\W6lZTDjc5VvfGW{LDDNTWM6OD1yLkNOwG0> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl5MEmzO{c,OjJ7N{C5N|c9N2F-
HFF NIHySodCdnSrYYDpZ49ueGyneHHuJIF{e2G7 MXuyOEBpenN? MlTkRY51cWGyaXPvcZBt\XijbjDhZ5Rqfmm2eTDh[4FqdnO2IGTvfI9xdGG|bXGg[49v\GmrIGLIJJRi[2i7en;peIV{KGmwZnXjeIVlKGmwIFjGSkBk\WyuczDhd5Nme3OnZDDhd{BcO0ifLYXyZYNqdCCrbnPvdpBwemG2aX;uJIFnfGW{IEK0JIhzeyCkeTDzZ4lvfGmubHH0bY9vKGy3bXnu[ZNk\W6lZTDjc5VvfGW{LDDNTWM2OD1yLkNOwG0> NHT2XVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm3NFk{Pyd-MkK5O|A6Ozd:L3G+
MDA-MB-231 NV24bI17S3m2b4TvfIlkcXS7IHHzd4F6 MYfDXZRwfG:6aXPpeJkh[WejaX7zeEBGWi2wZXfheIl3\SCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIJ6KE2WUzDhd5NigSxiSVO1NF0xNjd7zszN MoDuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MU[xPVEoRjJ|NEG2NVkyRC:jPh?=
MCF7 M{fVWmN6fG:2b4jpZ4l1gSCjc4PhfS=> NUK5PFBqS1m2b4TvfIlkcXS7IHHnZYlve3RiRWKtdI9{cXSrdnWgbJVu[W5iTVPGO{Bk\WyuczDifUBOXFNiYYPzZZktKEmFNUC9NU4xPs7:TR?= NEL2V3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOlE6OSd-MkO0NVYyQTF:L3G+
AsPC1 Mn\ZR5l1d3SxeHnjbZR6KGG|c3H5 NVOzfpI5S1m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSXOSQ{GgZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyPUGuOFfPxE1? NUXu[nBkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVYyQTFpPkKzOFE3OTlzPD;hQi=>
PANC1 NG\SOYxEgXSxdH;4bYNqfHliYYPzZZk> MYXDXZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQRW5EOSClZXzsd{BjgSCPVGOgZZN{[XluIFnDOVA:OS55M988US=> NW\RW|JZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVYyQTFpPkKzOFE3OTlzPD;hQi=>
HEK293 MmTTSpVv[3Srb36gZZN{[Xl? MmfuPEBpenN? MoHwTY5pcWKrdHnvckBw\iCZboSzRU9j\XSjLXPhd4VqdiC|aXfuZYxqdmdiaX6gTGVMOjl|IHPlcIx{KGGodHXyJFghcHK|IHL5JHRQWG[uYYPoJJJmeG:{dHXyJIF{e2G7LDDJR|UxRTBwNN88US=> MkTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUOwO|MoRjJ|NEWzNFc{RC:jPh?=
U2OS NGe3OGNHfW6ldHnvckBie3OjeR?= NHLuOXoyOi53IIXN NGO2bZY3KGi{cx?= MnzLTY5lfWO2aX;uJI9nKGmwdHXycoFtcXqjdHnvckBw\iCIcnn6foxm\DFvR1\QJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKGi3bXHuJHUzV1NiY3XscJMh[XRiMUKuOUB2VSCjZoTldkA3KGi{czDifUBkd26ob3PhcEBucWO{b4Pjc5B6 MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3M{C3N{c,OjN2NUOwO|M9N2F-
MDA-MB-231 NWDNSFZ7S3m2b4TvfIlkcXS7IHHzd4F6 Mor0O|IhcHK| M3THRWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGVTKG6nZ3H0bZZmKE2GQT3NRk0zOzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlc6|ryP MorLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUm2NVMoRjJ|NEW5OlE{RC:jPh?=
MCF7 Mk\KR5l1d3SxeHnjbZR6KGG|c3H5 NEHn[Zk4OiCqcoO= MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDFVkBxd3OrdHn2[UBOS0Z5IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFNiYYPzZZktKEmFNUC9NU4xPs7:TR?= NWK4dlBIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OVk3OTNpPkKzOFU6PjF|PD;hQi=>
AsPC1 M{\aN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NILCZ484OiCqcoO= MoG3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRZNRSzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2xMlQ4|ryP MmqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUm2NVMoRjJ|NEW5OlE{RC:jPh?=
PANC1 NF3VPIlEgXSxdH;4bYNqfHliYYPzZZk> Mm[2O|IhcHK| MlTTR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VWyCjc4PhfUwhUUN3ME2xMlc{|ryP M1fSb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW5OlE{Lz5{M{S1PVYyOzxxYU6=
MDA-MB-231 MYTBcpRqfHWvb4KgZZN{[Xl? M37YUFc2KG2pL3vn MWq1JIRigXN? Mli4RY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iRWKgcoVo[XSrdnWgUWRCNU2ELUKzNUBk\WyuczD4[Y5w\3KjZoTl[EBqdiCwdXTlJI1wfXOnIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIXtc5Ih\3Kxd4ToJIF1KDd3IH3nM4toNCCybzDx[EBnd3JiNTDkZZl{ M{jmXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEW5OlE{Lz5{M{S1PVYyOzxxYU6=
MDA-MB-231 M3S2RWFvfGm2dX3vdkBie3OjeR?= Mmj0NVIvPSCvZz;r[y=> NHPoUoQ2KGSjeYO= M2HsNmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFXSJI5m\2G2aY\lJG1FSS2PQj2yN|Eh[2WubIOgfIVvd2e{YX\0[YQhcW5iboXk[UBud3W|ZTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT1cY9zKGe{b4f0bEBifCBzMj61JI1oN2upLDDpdEBy\CCob4KgOUBl[Xm| MmC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NUm2NVMoRjJ|NEW5OlE{RC:jPh?=
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MDA-MB-231 NGPwWolHfW6ldHnvckBie3OjeR?= M{Toe|EhfG9iMUCgeW0> MoDJOFghcHK| NFz5PJBKdmS3Y4Tpc44hd2ZibX;ydIhwdG:paXPhcEBkcGGwZ3XzJIlvKGi3bXHuJGVTKG6nZ3H0bZZmKE2GQT3NRk0zOzFiY3XscJMh[XRiMTD0c{AyOCC3TTDh[pRmeiB2ODDodpMh[nlibHnnbJQhdWmlcn;zZ49xcWNiYX7hcJl{cXN? NH7WS|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S1PVYyOyd-MkO0OVk3OTN:L3G+
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MDA-MB-231 NHrGVldHfW6ldHnvckBie3OjeR?= M2HQVlEhfG9iMUCgeW0> NG\Xb2gzPCCqcoO= M{HweWlvcGmkaYTpc44hd2ZiU2TBWFMhcW5iaIXtZY4hTVJibnXnZZRqfmViTVTBMW1DNTJ|MTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YheGixc4Doc5J6dGG2ZXSgV3RCXDNiYYSgWJlzNTdyNTDs[ZZmdCCjdDCxJJRwKDFyIIXNJIFnfGW{IEK0JIhzeyCkeTDX[ZN1\XKwIHLsc5Qh[W6jbInzbZM> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR3OU[xN{c,OjN2NUm2NVM9N2F-
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DU145 NEf5XoJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnLaO|IhcHK| MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKESXMUS1JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC55zszN M1P0UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwNlMyLz5{NEmwNFI{OTxxYU6=
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HeLa MnfFRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NU\xfpB3PzJiaILz NUHpU5lWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MT60{txO MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEKzNUc,OjR7MECyN|E9N2F-
A549 NFHFUItCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M4rzXlczKGi{cx?= Ml7zRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:O87:TR?= MnqzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MECyN|EoRjJ2OUCwNlMyRC:jPh?=
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BT-12 MlvDdWhVWyCjc4PhfS=> M3XtdJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCEVD2xNkBk\Wyucx?= NWHYNGdORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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BT-37 MYnxTHRUKGG|c3H5 NYewe5NDeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhSlRvM{egZ4VtdHN? Mn;3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
TC32 MUjxTHRUKGG|c3H5 M4q0cJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHREOzJiY3XscJM> M3GwWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R) NHTVVGFyUFSVIHHzd4F6 MlztdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgUWchPjNiKE[tWGchWiliY3XscJM> NFrMVGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
fibroblast cells MVTxTHRUKGG|c3H5 M{HwcZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJINwdnS{b3ygTIghf2muZDD0fZBmKG[rYoLvZoxie3RiY3XscJM> NUfzeGVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
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LN229 NWfOZVk{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MofJOUBl[Xm| NYrj[otKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMUlIzQSClZXzsd{Bi\nSncjC1JIRigXNiYomgRYxidWG{Qnz1[UBie3OjeTygTWM2OD1yLkROwG0> NIHP[3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEW4N|I1QCd-M{C1PFMzPDh:L3G+
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KG1 MXHDfZRwfG:6aXPpeJkh[XO|YYm= M{LaWFMh\GG7cx?= Mn3KR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2cyKGOnbHzzJIlv[3WkYYTl[EBnd3JiMzDkZZl{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdnRiYYPzZZktKEmFNUC9NE4{Ps7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJ3M{WyPUc,OzF{NUO1Nlk9N2F-
Jurkat M3mwPWN6fG:2b4jpZ4l1gSCjc4PhfS=> M13jVlMh\GG7cx?= NH7QT3lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBLfXKtYYSgZ4VtdHNiaX7jeYJifGWmIH\vdkA{KGSjeYOgZpkhS2WubGTpeIVzNUeubzDseY1qdmW|Y3XueEBie3OjeTygTWM2OD1yLkVOwG0> MlP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{NUO1NlkoRjNzMkWzOVI6RC:jPh?=
NALM6 MW\DfZRwfG:6aXPpeJkh[XO|YYm= MorxN{Bl[Xm| NH\nbppEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPSUyPNjDj[YxteyCrbnP1ZoF1\WRiZn;yJFMh\GG7czDifUBE\WyuVHn0[ZIuT2yxIHz1cYlv\XOlZX70JIF{e2G7LDDJR|UxRTBwNkNOwG0> NWmzU41sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVM2OjlpPkOxNlU{PTJ7PD;hQi=>
HEK293 NYK2VHN5TnWwY4Tpc44h[XO|YYm= M3rQWVkxKG2rboO= NHTofo5KdmirYnn0bY9vKG:oIFvJXE1TVHWlTjDmeZNm\CCFQmCgLJVvc26xd36gc5Jq\2mwKTDibY5lcW6pIITvJGtKTC2UTIXjR{BnfXOnZDDDVmVDKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gbJVu[W5iSFXLNlk{KGOnbHzzJJBz\WmwY4XiZZRm\CC5aYToJINwdXCxdX7kJFMxKG2rboOgZoVnd3KnIHLl[o9z\SCob4Lzb49tcW5iYXTkbZRqd25iYX7kJI1m[XO3cnXkJIFnfGW{IEmwJI1qdnNiaX6gdJJme2WwY3Wgc4Yh[2:nbHXueIVz[XpuIFnDOVA:OS53M988US=> NWjFb3V1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyOVM2OjlpPkOxNlU{PTJ7PD;hQi=>
293beta5 NVfR[WFuSW62aY\pdoFtKGG|c3H5 NX\lUFFEPyCmYYnz NVq4V5V4SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUHWvYX6gZYRmdm:4aYL1d{A2KGmwZnXjeIVlKGmwIEK5N4JmfGF3IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YheGyjcYXlJIZwem2jdHnvckBqdmO3YnH0[YQh\m:{IEeg[IF6eyCkeTDHSnAhemWyb4L0[ZIh\2WwZTDhd5NigSxiSVO1NF0xNjcQvF2= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OjB2NUKzPUc,OzJyNEWyN|k9N2F-
A549 MYPBcpRqfmm{YXygZZN{[Xl? MoDSOFghcHK| M{LSNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIHHk[Y5wfmm{dYOgOUBqdm[nY4Tl[EBqdiCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXyg[Y51enliYX\0[ZIhPDhiaILzJIJ6KEeIUDDy[ZBwenSncjDn[Y5mKGKjc3XkJIF{e2G7LDDJR|UxRTFwMkNOwG0> MoLxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzJyNEWyN|koRjN{MES1NlM6RC:jPh?=
A549 MV7DfZRwfG:6aXPpeJkh[XO|YYm= M{nhPFQ5KGi{cx?= MVHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZktKEOFNUC9NlIvQc7:TR?= NIf2W2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MkC0OVI{QSd-M{KwOFUzOzl:L3G+
Vero NVTD[3Q3TnWwY4Tpc44h[XO|YYm= MnL0WoVzdyClZXzsd{B3cWGkaXzpeJkheUiWUzDmc5IhYmmtYTD2bZJ2eyCrbnjpZol1d3K| NITyVXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|M{KyPVU1PSd-M{OyNlk2PDV:L3G+
Vero MmDJRY51cX[rcnHsJIF{e2G7 NV:1UlVmOjRiaIK= MUXBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDTRXJUNUOxVj2yJEh3cXKjbDD0bZRmeilibXXhd5Vz\WRiYomgdIxieXWnIHHzd4F6KGmwIG\ldo8h[2WubIOgZZQhVU:LIECuNFEzPSCjZoTldkAzPCCqcjygTWM2OD1yLkK4{txO MmG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVQ1QC9pPlPoSW1DVDxxYU6=
skeletal myoblast cells M3vESWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYHzSIZOPzJiaB?= MmXLSG5FUTpiQ4n0c5RwgGmlaYT5JIlvKF[rdILvMEA4OiCqb4XyMEBqdiC{YYSgd4tmdGW2YXygcZlw[myjc4SgZ4VtdHNuIFnDOVA:Oi5|zszN MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxOFQ5Nyd-Q3jFUWJNRC:jPh?=
VERO-E6 NGq1cWdHfW6ldHnvckBie3OjeR?= M1e0R|Q5KGi{cx?= NX7PdVJ7TGW2ZYLtbY5ifGmxbjDv[kBKSzVyII\hcJVmeyCob4KgbY5pcWKrdHnvckBw\iCVQWLTMWNwXi1{IHnu[JVk\WRiY4n0c5RwgGmlaYT5JI9nKF[HUl:tSVYh[2WubIOgZYZ1\XJiNEigbI92enNiIHX4dI9{fXKnIITvJFAvODFiTV;JJHNCWlNiQ3;WMVIhfmm{dYOgZpkhcGmpaDDjc451\W62IHntZYdqdmduIFnDOVA:PC5zzszN M4PRVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE1PDhxJ{7DbGVOSkx:L3G+
Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot p-STAT3 / STAT3 / c-Myc / Survivin ; p-BCR-ABL / BCR-ABL ; p-STAT5 / STAT5 / p-AKT / AKT / p-ERK / ERK ; β-catenin 25970160 29358661 27652012
Growth inhibition assay Cell viability 28418862
In vivo Niclosamide(40 mg/kg/d, i.p.) inhibits growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors. [4]

Protocol (from reference)

Kinase Assay:

[1]
  • Protein Kinase profiling assay:

    Assay for 22 different proteins kinases is carried out by ProQinase Gmbh. All of the protein kinases are expressed either in Sf9 insect cells or in E.coli as recombinant GST-fusion proteins or His-tagged proteins. Protein kinases are purified by affinity chromatography using either GSH-agarose or Ni_NTH-agarose. A radiometric protein kinase assay is used for measuring the kinase activity of the 22 protein kinases. Briefly, for each protein kinase, 50 μL reaction cocktail containing 60 mM HEPES-NaOH, 3 mM MgCl2, 3 mM MnCl2, 3 μM Na-orthovanadate, 1.2 mM DTT, 50 μg/mL PEG20000, 1 μM [γ-33P]-ATP, Niclosamide, adequate amount of enzyme and its substrate. The PKC-alpha assay additionally contain 1 mM Cacl2, 4 mM EDTA, 5 μg/mL phosphatidylserine and 1 μg/mL 1, 2-Dioleyl-glycerol. The reaction cocktails are incubated at 37 °C for 60 minutes and stop with 50 μL 2% (v/v) H3PO4. Incorporation of 33Pi is determined with a microplate scintillation counter. The activities and the IC50 values are calculated using Quattro Workflow V2.28.
Cell Research:

[1]
  • Cell lines: Hela, A549, Du145, HT-29, A431, PC3 cells
  • Concentrations: 16 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are plated in 96-well culture plates with cell density of 3-4 × 103 cells/well and treat with Niclosamide by adding 100 μL medium containing Niclosamide of various concentrations on the second day. After 72-hour's treatment, MTT is added to each well and incubated for additional 4-5 hours, and the absorbance is measured on a microplate reader at 570nm. Cell growth inhibition is evaluated as the ratio of the absorbance of the sample to that of the control. The results are representative of at least 3 independent experiments.
Animal Research:

[4]
  • Animal Models: nude mice bearing HL-60 xenograft tumors.
  • Dosages: 40 mg/kg
  • Administration: Intraperitoneal injection

Solubility (25°C)

In vitro

 DMF 12 mg/mL warmed
(36.68 mM)
DMSO Insoluble
Water Insoluble

Chemical Information

Molecular Weight 327.12
Formula

C13H8Cl2N2O4
CAS No. 50-65-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05188170 Not yet recruiting Drug: Niclosamide Acute Myeloid Leukemia (AML) Stanford University July 2022 Phase 1
NCT05168644 Recruiting Drug: Niclosamide Inhalation Powder|Drug: Placebo Healthy TFF Pharmaceuticals Inc. November 14 2021 Phase 1
NCT04436458 Not yet recruiting Drug: Niclosamide Oral Tablet|Drug: Placebo COVID First Wave Bio Inc. June 2021 Phase 2
NCT04644705 Completed Drug: Niclosamide|Drug: Placebo Healthy Volunteers Charité Research Organisation GmbH|Bayer November 2 2020 Phase 1
NCT04592835 Not yet recruiting Drug: DWRX2003 COVID-19 Patients Daewoong Pharmaceutical Co. LTD.|Novotech (Australia) Pty Limited October 19 2020 Phase 1
NCT04524052 Not yet recruiting Drug: DWRX2003|Drug: Placebo Healthy Daewoong Pharmaceutical Co. LTD. August 2020 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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