BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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Cited by 10 Publications

4 Customer Reviews

  • Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

    Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

  • (A) Washed human platelets were untreated or pretreated with the PDK1 inhibitor BX-795 (1 μM) for 5 min, and this was followed by stimulation with 2-methylthio-ADP (2MeSADP) (50 nM) under stirring for 5 min. Western blots were then probed for phosphorylated Akt (Thr308), Akt (Ser473), glycogen synthase kinase 3b (GSK3b) (Ser9), mitogen-activated protein kinase kinase 1/2 (MEK1/2) (Ser217/221), extracellular signal-regulated kinase 1/2 (ERK1/2) (Thr202/Tyr204), and cytosolic phospholipase A2 (cPLA2) (Ser505). The western blots shown are representative of three independent experiments.

    J Thromb Haemost, 2018, 16(6):1211-1225. BX-795 purchased from Selleck.

    Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NInRPHNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIfQPW9KdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi56IH7N NH;hNlBUSU6JRWK=
KRX cells M13yPGZ2dmO2aX;uJIF{e2G7 Ml\WO{BucW6| M4jQbmlvcGmkaYTpc44hd2ZiU2XNU{11[WepZXSgWWxMOSBqdX7rco94diCxcnnnbY4qKGurbnHz[UBld22jaX6g[ZhxemW|c3XkJIlvKEuUWDDj[YxteyC3c3nu[{BcOzKSXT3nZY1u[S2DVGCgZY5lKG27ZXzpckBj[XOrYzDwdo91\WmwIIP1ZpN1emG2ZTDpcoN2[mG2ZXSg[o9zKDdibXnudy=> NFP3NJEzPjJ5NU[4NS=>
human NKM-1 cell NELwcopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOlE6PCEQvF2= MYnTRW5ITVJ?
human P30-OHK cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVX0NHFkUW6qaXLpeIlwdiCxZjDoeY1idiCSM{CtU2hMKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImsJGlEPTB;MD60PVY2KM7:TR?= MonOV2FPT0WU
human YH-13 cell NXvjV|RCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml2wTY5pcWKrdHnvckBw\iCqdX3hckB[UC1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOlI5QDhizszN MV7TRW5ITVJ?
human LXF-289 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYDJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU4hUUN3ME2wMlY2Pjl|IN88US=> NEPlSlBUSU6JRWK=
human BE-13 cell NYT2VnRzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnniTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A1PzdizszN M{TTZ3NCVkeHUh?=
human RS4-11 cell Mn:5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17CV2lvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OjV7NDFOwG0> M4ezdnNCVkeHUh?=
human A3-KAW cell NGXHSm5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mmn3TY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc{ODV3IN88US=> MUnTRW5ITVJ?
human PA-1 cell NHrIVGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml7hTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64NFQzOiEQvF2= M1\PZnNCVkeHUh?=
human ES7 cell NY\ubGRZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEO1OlYh|ryP MnW5V2FPT0WU
human ES8 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUO5d|lUUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg1OzN4IN88US=> MXrTRW5ITVJ?
human SW982 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NG\ZenpKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46PTF{NDFOwG0> MoHMV2FPT0WU
human VA-ES-BJ cell NETGbohIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MknLTY5pcWKrdHnvckBw\iCqdX3hckBXSS2HUz3CTkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTh2Nkeg{txO MoLwV2FPT0WU
human 697 cell NHfJOYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUftTXpVUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyPjJ|IN88US=> M1;mS3NCVkeHUh?=
human MOLT-4 cell Moj0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrwemJKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODN{NESg{txO M2\oSnNCVkeHUh?=
human D-283MED cell NGnlXmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmDETY5pcWKrdHnvckBw\iCqdX3hckBFNTJ6M13FSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODN7NEig{rxu M4nJVHNCVkeHUh?=
human ALL-PO cell M2K1Vmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn7zTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODd|IN88US=> NGn2cmxUSU6JRWK=
human NB14 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC2NFgyKM7:TR?= NVT4[5JGW0GQR1XS
human NTERA-S-cl-D1 cell NVnUboFjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHrqW5hKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA4Pzd3IN88US=> NXLGbWsxW0GQR1XS
human BFTC-905 cell M1jDS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUTJcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDFyMTFOwG0> MYjTRW5ITVJ?
human H4 cell Mmr0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVHJcohq[mm2aX;uJI9nKGi3bXHuJGg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zMEKwNUDPxE1? M2PzdnNCVkeHUh?=
human CHP-212 cell NHrwfWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXnoZnBRUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNlEzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zNECzO{DPxE1? M3TKOXNCVkeHUh?=
human A204 cell NFrqbJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3[2NWlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU1PjdizszN MVLTRW5ITVJ?
human NB69 cell M3\4bGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnL4TY5pcWKrdHnvckBw\iCqdX3hckBPSjZ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVg3PSEQvF2= NHLodnBUSU6JRWK=
human P12-ICHIKAWA cell NIjPWWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fCbGlvcGmkaYTpc44hd2ZiaIXtZY4hWDF{LVnDTGlMSVeDIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE4OSEQvF2= MXzTRW5ITVJ?
human L-363 cell M3nnVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4LmbGlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTl5IN88US=> NFHqWYlUSU6JRWK=
human ES5 cell M3m5Z2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13ZZmlvcGmkaYTpc44hd2ZiaIXtZY4hTVN3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPVM2PCEQvF2= MX3TRW5ITVJ?
human CAL-51 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3TWVmlvcGmkaYTpc44hd2ZiaIXtZY4hS0GOLUWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zOjF3NjFOwG0> NEnSeZRUSU6JRWK=
human NBsusSR cell MmXTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk\BTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> NVHTbHpMW0GQR1XS
human HOP-92 cell NVrCR3JjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoH3TY5pcWKrdHnvckBw\iCqdX3hckBJV1BvOUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI4Ojl|IN88US=> M3nPUHNCVkeHUh?=
human DU-4475 cell NVTqelJWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLjdINjUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK0OUDPxE1? NGrSRYlUSU6JRWK=
human LB1047-RCC cell M2WzSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH7GS|VKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkK5NlgyKM7:TR?= MYrTRW5ITVJ?
human D-566MG cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3jSNmlvcGmkaYTpc44hd2ZiaIXtZY4hTC13Nk\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzB2NEig{txO MnrXV2FPT0WU
human A375 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX7ObWtNUW6qaXLpeIlwdiCxZjDoeY1idiCDM{e1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODh3ODFOwG0> Mmi1V2FPT0WU
human ATN-1 cell MonHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXCO5NKdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzF6NTFOwG0> MXLTRW5ITVJ?
human M059J cell NHPNdWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjwV5hKdmirYnn0bY9vKG:oIHj1cYFvKE1yNUnKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzZ3MjFOwG0> MV;TRW5ITVJ?
human HSC-3 cell MlTRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF\NOmxKdmirYnn0bY9vKG:oIHj1cYFvKEiVQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDJyODFOwG0> MnWzV2FPT0WU
human DOHH-2 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{jPbmlvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PThzNDFOwG0> NHzj[HdUSU6JRWK=
human G-402 cell MmLOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1;0eGlvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ3PTJ3IN88US=> M4L0eXNCVkeHUh?=
human LC-2-ad cell MlzlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkHUTY5pcWKrdHnvckBw\iCqdX3hckBNSy1{LXHkJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PzF|MjFOwG0> NIW4[Y1USU6JRWK=
human LOXIMVI cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHTtWWlKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>? NX\SfZNmW0GQR1XS
human DK-MG cell M33pOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mlj3TY5pcWKrdHnvckBw\iCqdX3hckBFUy2PRzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVczQThizszN M{HTUXNCVkeHUh?=
human HOS cell NELKb5RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\yb3VUUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=> MXnTRW5ITVJ?
human BHT-101 cell NV:4bI5RT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkLTTY5pcWKrdHnvckBw\iCqdX3hckBDUFRvMUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42Pzh5NzFOwG0> MXLTRW5ITVJ?
human U-2-OS cell NXjXT3ZET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4XxPWlvcGmkaYTpc44hd2ZiaIXtZY4hXS1{LV;TJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42QDhyNjFOwG0> MWDTRW5ITVJ?
human D-423MG cell Mn7XS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmjXTY5pcWKrdHnvckBw\iCqdX3hckBFNTR{M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODhyNjFOwG0> M3\6WnNCVkeHUh?=
human AN3-CA cell NXrWPGdOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{LDbWlvcGmkaYTpc44hd2ZiaIXtZY4hSU5|LVPBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43Ozl7MTFOwG0> MUDTRW5ITVJ?
human TE-11 cell NFHtbmxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3zRd2lvcGmkaYTpc44hd2ZiaIXtZY4hXEVvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlY2OjhizszN NVftdYhWW0GQR1XS
human SK-NEP-1 cell Mm[xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HiTWlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ3M{e2JO69VQ>? MWfTRW5ITVJ?
human MG-63 cell MlXSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPnSHNsUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO NVzIVnNyW0GQR1XS
human RH-1 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3r6NGlvcGmkaYTpc44hd2ZiaIXtZY4hWkhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|AzPzRizszN NW[5Tld5W0GQR1XS
human MDA-MB-157 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkDkTY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNVU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55MU[3OEDPxE1? M3\VSXNCVkeHUh?=
human A427 cell MlGzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOVg6KM7:TR?= MWfTRW5ITVJ?
human ES1 cell NVm0T4c2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MonHTY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke1OFUyKM7:TR?= NVH3NGNjW0GQR1XS
human C32 cell NUjlR3hET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGM{OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{[zPUDPxE1? NGLEc5ZUSU6JRWK=
human LAMA-84 cell NHvVemVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUPG[Y1yUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? MlSxV2FPT0WU
human YKG-1 cell M4nRWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUf0Z|dDUW6qaXLpeIlwdiCxZjDoeY1idiC\S1etNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzdzMkSg{txO NF:2bZdUSU6JRWK=
human NCI-H1048 cell NE\rZnlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzh3MEmg{txO MVXTRW5ITVJ?
human KS-1 cell M3zHeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIDHdJFKdmirYnn0bY9vKG:oIHj1cYFvKEuVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlgzQThizszN MmX5V2FPT0WU
human JVM-3 cell M{nSXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= MXTTRW5ITVJ?
human GI-ME-N cell MkLpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PTNizszN NV3TTZN2W0GQR1XS
human GT3TKB cell Mor4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPWNVRKdmirYnn0bY9vKG:oIHj1cYFvKEeWM2TLRkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDl4NEKg{txO MVvTRW5ITVJ?
human CHL-1 cell NHf6NoxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUH4fmtkUW6qaXLpeIlwdiCxZjDoeY1idiCFSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTJ|N{mg{txO M4LiXnNCVkeHUh?=
human CHP-134 cell NWn4WmV[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlHKTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> MonkV2FPT0WU
human 8-MG-BA cell MlTRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJFguVUdvQlGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk2PzR2IN88US=> NXLBWJNJW0GQR1XS
human HO-1-N-1 cell M3PwRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> NX;oVXJLW0GQR1XS
human SW1088 cell M{j0UGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWnJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTB6ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVk3PzNizszN NVPOXZpxW0GQR1XS
human SW48 cell M3PwWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHzKVWhKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlAzODZ5IN88US=> NX[wZYFZW0GQR1XS
human VM-CUB-1 cell Ml61S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWDxPZhrUW6qaXLpeIlwdiCxZjDoeY1idiCYTT3DWWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMESxNVkh|ryP MX\TRW5ITVJ?
human COLO-800 cell NULkfYYyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmrPTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiwNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODVzM{[g{txO Moj0V2FPT0WU
human TI-73 cell M4jHW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVTRVm5iUW6qaXLpeIlwdiCxZjDoeY1idiCWST23N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTF|OUmg{txO M1;HTHNCVkeHUh?=
human HN cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGhPKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMkG5PEDPxE1? MVjTRW5ITVJ?
human DB cell MnnuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMk[zNUDPxE1? NH3BT5VUSU6JRWK=
human Ca9-22 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkjZTY5pcWKrdHnvckBw\iCqdX3hckBE[TlvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEzQDR5IN88US=> Ml7WV2FPT0WU
human A549 cell NGPVSVJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLITY5pcWKrdHnvckBw\iCqdX3hckBCPTR7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xN|gxQCEQvF2= MmfPV2FPT0WU
human KGN cell NUnGTXp4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWDJcohq[mm2aX;uJI9nKGi3bXHuJGtIViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMkK1PVUh|ryP NG\5N3JUSU6JRWK=
human BCPAP cell M1\FS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoX1TY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN MmrQV2FPT0WU
human Ramos-2G6-4C10 cell NH2yRnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M13UR2lvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{PzV7IN88US=> M3\HUXNCVkeHUh?=
human OVCAR-5 cell NUPQRWc4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk\UTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd|NDFOwG0> NGTNeopUSU6JRWK=
human KG-1 cell Moq4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnmyTY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yO|c6OiEQvF2= MX3TRW5ITVJ?
human CAKI-1 cell NI\PUWZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfkd3NKdmirYnn0bY9vKG:oIHj1cYFvKEODS1mtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjhyNUig{txO M3;IenNCVkeHUh?=
human QIMR-WIL cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3jv[mlvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6N{S0JO69VQ>? NIfDbWFUSU6JRWK=
human SW1710 cell NITic4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGK2[oNKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUexNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjlzNEKg{txO M4TyWHNCVkeHUh?=
human SK-UT-1 cell NX\OdGNJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzRZYpKdmirYnn0bY9vKG:oIHj1cYFvKFONLWXUMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ7M{O5JO69VQ>? M3PDPHNCVkeHUh?=
human IST-SL1 cell NHTkWJNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2rFVmlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzJzN{Sg{txO MYPTRW5ITVJ?
human SW962 cell MnXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zN|c2PyEQvF2= M1LMNnNCVkeHUh?=
human EM-2 cell NHTXNHNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnrTTY5pcWKrdHnvckBw\iCqdX3hckBGVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zOVM{PyEQvF2= Mn;nV2FPT0WU
human D-263MG cell Mn;5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWXiT4VsUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|OEOyO{DPxE1? M2HpSHNCVkeHUh?=
human T98G cell MlXNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlXYTY5pcWKrdHnvckBw\iCqdX3hckBVQTiJIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPFg2PyEQvF2= MnvyV2FPT0WU
human CTB-1 cell NY\nOYdOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPVc3OSEQvF2= NXrNOpZNW0GQR1XS
human Hs-578-T cell MmPIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGh{NTV5OD3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OTV6NzFOwG0> MVvTRW5ITVJ?
human SF126 cell NGXhdmFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjnTY5pcWKrdHnvckBw\iCqdX3hckBUTjF{NjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOFM3OjFizszN MYfTRW5ITVJ?
human NCI-H460 cell NVvEWnFrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mke0TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSES2NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN7NUWg{txO NEXTZ|NUSU6JRWK=
human NCI-H1755 cell NImzSlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGn4Xm5KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUSwOFMh|ryP MnnUV2FPT0WU
human HL-60 cell MojxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYK1SG5{UW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRzNUmg{txO NHLRbpZUSU6JRWK=
human G-401 cell M2OyUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3PnUGlvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3ODl7IN88US=> MVnTRW5ITVJ?
human AGS cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGFIWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNU[yOVch|ryP Mor1V2FPT0WU
human HuO9 cell MljKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnzTTY5pcWKrdHnvckBw\iCqdX3hckBJfU97IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlQ2PiEQvF2= NVfFOIdTW0GQR1XS
human MFE-280 cell M2OzNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\tTGlvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO MlPTV2FPT0WU
human NCI-H292 cell NEGzO2xIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlzjTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTd5MkKg{txO Mn;RV2FPT0WU
human HuO-3N1 cell NWjGVll4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF[0XlhKdmirYnn0bY9vKG:oIHj1cYFvKEi3Tz2zUlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZyM{C3JO69VQ>? M4HRT3NCVkeHUh?=
human ES3 cell MnK0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEf2PYxKdmirYnn0bY9vKG:oIHj1cYFvKEWVMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOlIzQDVizszN NUnySIpVW0GQR1XS
human LB2241-RCC cell NEjBRWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn32TY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUC3PUDPxE1? NILLd4hUSU6JRWK=
human NCI-H1155 cell M{jxXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUXIRlJbUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5OFA2KM7:TR?= NELJTJhUSU6JRWK=
human SW872 cell M1;CO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHvzc|hKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44ODZ5NjFOwG0> MonmV2FPT0WU
human MHH-ES-1 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGDid|ZKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mk[zN{DPxE1? NXj3[FIxW0GQR1XS
human KYSE-150 cell M{XPOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1LySGlvcGmkaYTpc44hd2ZiaIXtZY4hU1mVRT2xOVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjd{OUeg{txO Mke1V2FPT0WU
human MC-IXC cell M3TPRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NInIXVdKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl3MzFOwG0> NYX4NVJ{W0GQR1XS
human HCC1187 cell M3KzeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJGhESzFzOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6Pjd5IN88US=> NWfJV2VIW0GQR1XS
human UMC-11 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnGyTY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> MVHTRW5ITVJ?
human NB5 cell M2DiR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDXTY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO|E2KM7:TR?= NUfYVWZqW0GQR1XS
human A2058 cell NH;J[49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHTY[VVKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0> MW\TRW5ITVJ?
human Becker cell NIG3T3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFHnV3RKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO MYXTRW5ITVJ?
human CAS-1 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGnZRmdKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTV4OTFOwG0> MnrNV2FPT0WU
human SW780 cell NWXW[lVNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHNYPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6yOVYxQSEQvF2= NWD1cItnW0GQR1XS
human KM12 cell NVzxPFZlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlrsTY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= NXTSXFNFW0GQR1XS
human PC-3 cell Mn\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlW4TY5pcWKrdHnvckBw\iCqdX3hckBRSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xO|QyOSEQvF2= MnfwV2FPT0WU
human A253 cell M{HpVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHywS2lKdmirYnn0bY9vKG:oIHj1cYFvKEF{NUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE5QDl|IN88US=> Mn;CV2FPT0WU
human NB10 cell MmPDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7sVWk6UW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zOjd5MzFOwG0> NX\OTYd5W0GQR1XS
human A172 cell MonTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGf5[WhKdmirYnn0bY9vKG:oIHj1cYFvKEFzN{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ1PTdizszN MnPzV2FPT0WU
human A498 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoC0TY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61OlM5OyEQvF2= MoDkV2FPT0WU
human SW1573 cell NVX5NmlGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVzv[2RQUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G1O|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjlyNEmxJO69VQ>? NYPnTlFSW0GQR1XS
human 5637 cell M4X6T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnu2TY5pcWKrdHnvckBw\iCqdX3hckA2PjN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6wO|kxPCEQvF2= NGrrToJUSU6JRWK=
human A388 cell M1\M[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVWxdoZkUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0> Ml\lV2FPT0WU
human U251 cell M1[1Rmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnHtTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= M{Hv[HNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
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    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID