BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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Cited by 10 Publications

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  • (A) Washed human platelets were untreated or pretreated with the PDK1 inhibitor BX-795 (1 μM) for 5 min, and this was followed by stimulation with 2-methylthio-ADP (2MeSADP) (50 nM) under stirring for 5 min. Western blots were then probed for phosphorylated Akt (Thr308), Akt (Ser473), glycogen synthase kinase 3b (GSK3b) (Ser9), mitogen-activated protein kinase kinase 1/2 (MEK1/2) (Ser217/221), extracellular signal-regulated kinase 1/2 (ERK1/2) (Thr202/Tyr204), and cytosolic phospholipase A2 (cPLA2) (Ser505). The western blots shown are representative of three independent experiments.

    J Thromb Haemost, 2018, 16(6):1211-1225. BX-795 purchased from Selleck.

    Induction of basal p62 Ser403 phosphorylation in ULK1/2-deficient MEF was suppressed by BX-795, an inhibitor of TBK1. WT ( Ulk1 +/+/Ulk2 +/+) and Ulk1 -/- /Ulk2 -/-(KO) MEF were treated with NaCl/Pi (Con) or 10 uM BX-795 for 6 h, and subjected to immunoblotting with indicated antibodies.

    FEBS J 2014 281(17), 3816-27. BX-795 purchased from Selleck.

  • Virology 2014 450-451, 182-95. BX-795 purchased from Selleck.

    Western blot analysis of pPRAS40 (T246), pS6 (S240/S244), and pS6 (S235/S236) proteins in (A) HeyA8 cells and (B) SKOV3 cells treated with 3.33 μM or 10 μM inhibitors (BX795 or CCT128930) in three-dimensional cell culture for 24 hours. Ten percent fetal bovine serum was used in A and B.

    PLoS One, 2016, 11(5):e0155052. . BX-795 purchased from Selleck.

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XQVmlvcGmkaYTpc44hd2ZiaIXtZY4hVVZvND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM3Njhibl2= NV3kTpJ[W0GQR1XS
KRX cells M4[5dmZ2dmO2aX;uJIF{e2G7 NFnVfVM4KG2rboO= NHjZXYJKdmirYnn0bY9vKG:oIGPVUW8ufGGpZ3XkJHVNUzFiKIXub45wf25ib4Lp[4lvMSCtaX7hd4Uh\G:vYXnuJIV5eHKnc4Pl[EBqdiCNUmigZ4VtdHNidYPpcochYzN{UG2t[4FudWFvQWTQJIFv\CCveXXsbY4h[mG|aXOgdJJwfGWrbjDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiB5IH3pcpM> MVWyOlI4PTZ6MR?=
human NKM-1 cell NYT2c5B4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVnJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6zOlE6PCEQvF2= MkSwV2FPT0WU
human P30-OHK cell M{jORmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUTlSo1CUW6qaXLpeIlwdiCxZjDoeY1idiCSM{CtU2hMKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImsJGlEPTB;MD60PVY2KM7:TR?= NEPSfGJUSU6JRWK=
human YH-13 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4DweWlvcGmkaYTpc44hd2ZiaIXtZY4hYUhvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDh6IN88US=> Ml\LV2FPT0WU
human LXF-289 cell M4rMVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2e4TmlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NiCLQ{WwQVAvPjV4OUOg{txO MoHNV2FPT0WU
human BE-13 cell NHfTdYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTzTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A1PzdizszN NYrTU5NXW0GQR1XS
human RS4-11 cell MoL5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYL4VWZyUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{NUm0JO69VQ>? NXXtS5dzW0GQR1XS
human A3-KAW cell M{KyOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml\1TY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc{ODV3IN88US=> MXTTRW5ITVJ?
human PA-1 cell NWC0fmM1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzHOHBKdmirYnn0bY9vKG:oIHj1cYFvKFCDLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlgxPDJ{IN88US=> M1rPOnNCVkeHUh?=
human ES7 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVrtXFVVUW6qaXLpeIlwdiCxZjDoeY1idiCHU{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlg{PTZ4IN88US=> NV7IenJnW0GQR1XS
human ES8 cell M2PsT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlPyTY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLki0N|M3KM7:TR?= M4nqRXNCVkeHUh?=
human SW982 cell NW[5[ncyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGTkPHFKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE46PTF{NDFOwG0> MYnTRW5ITVJ?
human VA-ES-BJ cell NHPSWIRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHnCVVVKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OES2O{DPxE1? NUnsSmZuW0GQR1XS
human 697 cell M{HBSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\VTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCxOlI{KM7:TR?= MU\TRW5ITVJ?
human MOLT-4 cell M2LpWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFMzPDRizszN NEjIfHFUSU6JRWK=
human D-283MED cell M2WyXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rwN2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|OUS4JO6ddQ>? MlnrV2FPT0WU
human ALL-PO cell M{PMfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHq[|RKdmirYnn0bY9vKG:oIHj1cYFvKEGOTD3QU{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODZyN{Og{txO M1zKVHNCVkeHUh?=
human NB14 cell NGnFOo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmnRTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= MWTTRW5ITVJ?
human NTERA-S-cl-D1 cell M{W2cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlWzTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wO|c4PSEQvF2= NUeyN5d[W0GQR1XS
human BFTC-905 cell Mlv5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGHvWm5KdmirYnn0bY9vKG:oIHj1cYFvKEKIVFOtPVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yOEGwNUDPxE1? NVXJe25HW0GQR1XS
human H4 cell M{fUVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnf6TY5pcWKrdHnvckBw\iCqdX3hckBJPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUCyNFEh|ryP Mk\MV2FPT0WU
human CHP-212 cell NX62O29yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnHHTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPDB|NzFOwG0> MlzZV2FPT0WU
human A204 cell M2DhT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm[xTY5pcWKrdHnvckBw\iCqdX3hckBCOjB2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVQ3PyEQvF2= NF;5VJpUSU6JRWK=
human NB69 cell NEjIW|FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXzHbpFKUW6qaXLpeIlwdiCxZjDoeY1idiCQQk[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTh4NTFOwG0> NHrBVYtUSU6JRWK=
human P12-ICHIKAWA cell M{jlUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUi4V2h[UW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTdzIN88US=> NEKzenJUSU6JRWK=
human L-363 cell Mof2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmPYTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyQTdizszN NGHpfGRUSU6JRWK=
human ES5 cell M3z4emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGVUPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUmzOVQh|ryP NEXqfotUSU6JRWK=
human CAL-51 cell Mn7SS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV3NV2RZUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? NXm3VplIW0GQR1XS
human NBsusSR cell MlHrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF7CUIpKdmirYnn0bY9vKG:oIHj1cYFvKE6Ec4XzV3Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ2NUe4JO69VQ>? MX\TRW5ITVJ?
human HOP-92 cell M2\ldGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\RfYRKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD25NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd{OUOg{txO MV3TRW5ITVJ?
human DU-4475 cell M1fCNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnroTY5pcWKrdHnvckBw\iCqdX3hckBFXS12NEe1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zQTJ2NTFOwG0> NVXFdYNGW0GQR1XS
human LB1047-RCC cell NX7xcXZST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkixJO69VQ>? NWTPSHhSW0GQR1XS
human D-566MG cell NGfTO2RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWrDU2p1UW6qaXLpeIlwdiCxZjDoeY1idiCGLUW2Om1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|MES0PEDPxE1? M2P3THNCVkeHUh?=
human A375 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1S2TmlvcGmkaYTpc44hd2ZiaIXtZY4hSTN5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|A5PThizszN NGHTPJdUSU6JRWK=
human ATN-1 cell Ml3nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3m4VWlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4OTh3IN88US=> NYDOeHN2W0GQR1XS
human M059J cell M{HieGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHewSVZKdmirYnn0bY9vKG:oIHj1cYFvKE1yNUnKJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzZ3MjFOwG0> NETre5NUSU6JRWK=
human HSC-3 cell NWHpRYZkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jwWGlvcGmkaYTpc44hd2ZiaIXtZY4hUFOFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1OjB6IN88US=> MWnTRW5ITVJ?
human DOHH-2 cell NVG1bIw1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlmzTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ2QDF2IN88US=> M17DNHNCVkeHUh?=
human G-402 cell M1fk[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW[zNow{UW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDZ3MkWg{txO MXfTRW5ITVJ?
human LC-2-ad cell NF;aSmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGnLO5BKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR5MUOyJO69VQ>? MYDTRW5ITVJ?
human LOXIMVI cell NFLNVGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVr3VYxmUW6qaXLpeIlwdiCxZjDoeY1idiCOT2jJUXZKKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53MEW1NkDPxE1? NUjwblJMW0GQR1XS
human DK-MG cell M3PncWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX;p[m9XUW6qaXLpeIlwdiCxZjDoeY1idiCGSz3NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd{OUig{txO M4XtU3NCVkeHUh?=
human HOS cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYPnNIVUUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=> MmCyV2FPT0WU
human BHT-101 cell MknlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUDJcohq[mm2aX;uJI9nKGi3bXHuJGJJXC1zMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4QDd5IN88US=> MlHXV2FPT0WU
human U-2-OS cell NGrnSVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NE\3[FJKdmirYnn0bY9vKG:oIHj1cYFvKFVvMj3PV{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTh6ME[g{txO NWDhTI82W0GQR1XS
human D-423MG cell Ml\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkLwTY5pcWKrdHnvckBw\iCqdX3hckBFNTR{M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43ODhyNjFOwG0> NG\WbmZUSU6JRWK=
human AN3-CA cell Ml\iS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUDmN4p[UW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ|OUmxJO69VQ>? MnTrV2FPT0WU
human TE-11 cell NFfFdWRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGjFeppKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PTJ6IN88US=> NEnhbJdUSU6JRWK=
human SK-NEP-1 cell NXjCbJc6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkP0TY5pcWKrdHnvckBw\iCqdX3hckBUUy2QRWCtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV|N{[g{txO M4n4SHNCVkeHUh?=
human MG-63 cell NY\TbFB3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGi3bXHuJG1INTZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62PFU3PyEQvF2= NYm5NnRrW0GQR1XS
human RH-1 cell M3\YeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\GbmlvcGmkaYTpc44hd2ZiaIXtZY4hWkhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|AzPzRizszN MVrTRW5ITVJ?
human MDA-MB-157 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkGzTY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNVU4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55MU[3OEDPxE1? MV3TRW5ITVJ?
human A427 cell NUL1V3ZiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH7JPXRKdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{PTh7IN88US=> M1:wNXNCVkeHUh?=
human ES1 cell NYDtdZRPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGVUOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{W0OVEh|ryP NHr1TJZUSU6JRWK=
human C32 cell MnTxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHLL[4RKdmirYnn0bY9vKG:oIHj1cYFvKEN|MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|Y{QSEQvF2= MXHTRW5ITVJ?
human LAMA-84 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfXe5h6UW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? NWLCfHNPW0GQR1XS
human YKG-1 cell MnflS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HvS2lvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTJ2IN88US=> MVPTRW5ITVJ?
human NCI-H1048 cell M2Oxc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmDUTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd6NUC5JO69VQ>? MXHTRW5ITVJ?
human KS-1 cell M2LRTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP NIXNNGFUSU6JRWK=
human JVM-3 cell MlnYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXzTSXhlUW6qaXLpeIlwdiCxZjDoeY1idiCMVl2tN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQDZ2OUGg{txO NU\h[mF{W0GQR1XS
human GI-ME-N cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGdKNU2HLV6gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PTNizszN MWDTRW5ITVJ?
human GT3TKB cell NXLibpExT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2O3OmlvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QTZ2MjFOwG0> M1TxfHNCVkeHUh?=
human CHL-1 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;YN3FSUW6qaXLpeIlwdiCxZjDoeY1idiCFSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTJ|N{mg{txO NGDBTnhUSU6JRWK=
human CHP-134 cell M3PtPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn\mTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> MVrTRW5ITVJ?
human 8-MG-BA cell NV7Ee3g{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DONmlvcGmkaYTpc44hd2ZiaIXtZY4hQC2PRz3CRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTV5NESg{txO NUfoPVNGW0GQR1XS
human HO-1-N-1 cell NWDjfpptT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> NXS2fGpnW0GQR1XS
human SW1088 cell NVzOfVV3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTB6ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPVk3PzNizszN NUHlcnJSW0GQR1XS
human SW48 cell M4HObGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKGi3bXHuJHNYPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkCyNFY4KM7:TR?= M1;wTHNCVkeHUh?=
human VM-CUB-1 cell M3[0emdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MofJTY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO NVW4O2NnW0GQR1XS
human COLO-800 cell M3:3b2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mlf4TY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiwNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODVzM{[g{txO MY\TRW5ITVJ?
human TI-73 cell M2nQd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3[wZmlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEyOzl7IN88US=> MmfUV2FPT0WU
human HN cell MonrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2PzcWlvcGmkaYTpc44hd2ZiaIXtZY4hUE5iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNVk5KM7:TR?= MX7TRW5ITVJ?
human DB cell M2r3T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3PKV2lvcGmkaYTpc44hd2ZiaIXtZY4hTEJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyOlMyKM7:TR?= MkD5V2FPT0WU
human Ca9-22 cell NFf4[3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIfLS5pKdmirYnn0bY9vKG:oIHj1cYFvKEOjOT2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTJ6NEeg{txO M3\6dXNCVkeHUh?=
human A549 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{XJRWlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVM5ODhizszN NE\ZTpJUSU6JRWK=
human KGN cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPPWZFKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN NUS3Tm05W0GQR1XS
human BCPAP cell NXO2RWtlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUXCUJY3UW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO NGHxenlUSU6JRWK=
human Ramos-2G6-4C10 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnuS3N3UW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjN5NUmg{txO MYrTRW5ITVJ?
human OVCAR-5 cell NG[zPFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MULJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4PzN2IN88US=> NXfrdoJZW0GQR1XS
human KG-1 cell Ml;4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXe1[VV7UW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd7MjFOwG0> NFXNTm5USU6JRWK=
human CAKI-1 cell NHnN[YdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml[3TY5pcWKrdHnvckBw\iCqdX3hckBESUuLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI5ODV6IN88US=> Mk\TV2FPT0WU
human QIMR-WIL cell MlvuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXv5fYZnUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP M3H5cXNCVkeHUh?=
human SW1710 cell NYixU4t[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{XXfWlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTF2MjFOwG0> NF;z[lZUSU6JRWK=
human SK-UT-1 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NULoenlVUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OUOzPUDPxE1? MVvTRW5ITVJ?
human IST-SL1 cell M2TiUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> NIDldFZUSU6JRWK=
human SW962 cell M1vPUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nvSGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM{PzV5IN88US=> M2nudHNCVkeHUh?=
human EM-2 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO1N|M4KM7:TR?= NUO3dFlbW0GQR1XS
human D-263MG cell MojGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5OzJ5IN88US=> MonWV2FPT0WU
human T98G cell NGjzdIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVf0cHJZUW6qaXLpeIlwdiCxZjDoeY1idiCWOUjHJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{QDh3NzFOwG0> MVXTRW5ITVJ?
human CTB-1 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLH[ZRzUW6qaXLpeIlwdiCxZjDoeY1idiCFVFKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzl5NkGg{txO M2HYeHNCVkeHUh?=
human Hs-578-T cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGh{NTV5OD3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OTV6NzFOwG0> MX;TRW5ITVJ?
human SF126 cell NHPaOVRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXKxblZMUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO NIqwT3BUSU6JRWK=
human NCI-H460 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXHJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> MYHTRW5ITVJ?
human NCI-H1755 cell M2PDbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRyNEOg{txO MYHTRW5ITVJ?
human HL-60 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OFE2QSEQvF2= MnXJV2FPT0WU
human G-401 cell Mny3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDBzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlA6QSEQvF2= MlnNV2FPT0WU
human AGS cell NX3hT|l2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIDWe4ZKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYzPTdizszN NUT6V4tZW0GQR1XS
human HuO9 cell NEXaTphIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3uxdWlvcGmkaYTpc44hd2ZiaIXtZY4hUHWROTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVY1PTZizszN NEfMNXVUSU6JRWK=
human MFE-280 cell NEXhVI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWPTVFNsUW6qaXLpeIlwdiCxZjDoeY1idiCPRlWtNlgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53Nk[4OkDPxE1? NV71R|N{W0GQR1XS
human NCI-H292 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42Pzd{MjFOwG0> M2D1e3NCVkeHUh?=
human HuO-3N1 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3n1fmlvcGmkaYTpc44hd2ZiaIXtZY4hUHWRLUPONUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjB|MEeg{txO M37sPHNCVkeHUh?=
human ES3 cell NYK1eW9xT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1naUGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62NlI5PSEQvF2= MlHTV2FPT0WU
human LB2241-RCC cell M37VPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoTpTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUC3PUDPxE1? M3zmTnNCVkeHUh?=
human NCI-H1155 cell NYnh[2ZmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUG1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjl2MEWg{txO NV3VSFZ5W0GQR1XS
human SW872 cell MlruS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj63NFY4PiEQvF2= MkfxV2FPT0WU
human MHH-ES-1 cell Ml75S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWHJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2HUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44OjZ|MzFOwG0> M4TFS3NCVkeHUh?=
human KYSE-150 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml31TY5pcWKrdHnvckBw\iCqdX3hckBMYVOHLUG1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ7NzFOwG0> M3rnXnNCVkeHUh?=
human MC-IXC cell NHznb2pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4LDVmlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTV|IN88US=> NVrtb4hkW0GQR1XS
human HCC1187 cell NXztNIlST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHHGb2FKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{GxPFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7Nke3JO69VQ>? M2nLVnNCVkeHUh?=
human UMC-11 cell NFP3S5lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmDaTY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> NEnnO2VUSU6JRWK=
human NB5 cell NIHRdodIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmrSTY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO|E2KM7:TR?= MnjJV2FPT0WU
human A2058 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnTVTY5pcWKrdHnvckBw\iCqdX3hckBCOjB3ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVc5PDRizszN NFHhfphUSU6JRWK=
human Becker cell MlTHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHX0c2xKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO Mk\iV2FPT0WU
human CAS-1 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFfqNYNKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTV4OTFOwG0> NIXXUHdUSU6JRWK=
human SW780 cell Mof6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV;JfpNFUW6qaXLpeIlwdiCxZjDoeY1idiCVV{e4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvOjV4MEmg{txO MWLTRW5ITVJ?
human KM12 cell NGjpSFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEi2OWpKdmirYnn0bY9vKG:oIHj1cYFvKEuPMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlMxOTN{IN88US=> Ml6yV2FPT0WU
human PC-3 cell MojWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFrwR5FKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE4PDFzIN88US=> NWi2NGkyW0GQR1XS
human A253 cell NHqwW3lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVr5NpdHUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> M17PPXNCVkeHUh?=
human NB10 cell NYfXZnFJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1vqeWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PzNizszN MnOxV2FPT0WU
human A172 cell M1XHRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJGEyPzJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS0OVch|ryP NGG4bI9USU6JRWK=
human A498 cell NI[2bHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2D0N2lvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOVY{QDNizszN NX\RN|Z1W0GQR1XS
human SW1573 cell NW\yUmNLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTV5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uPVA1QTFizszN NUf2O2JuW0GQR1XS
human 5637 cell M3vqbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJFU3OzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkC3PVA1KM7:TR?= M{X6[nNCVkeHUh?=
human A388 cell NG\IcYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= M3eyb3NCVkeHUh?=
human U251 cell NUfn[ohOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXZOXhTUW6qaXLpeIlwdiCxZjDoeY1idiCXMkWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvOTF5NTFOwG0> MnLnV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID