BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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Cited by 19 Publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NVfPfGhOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIjtVY5KdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi56IH7N MoPRV2FPT0WU
KRX cells NV7Vd|E5TnWwY4Tpc44h[XO|YYm= NXzmPHgyPyCvaX7z MkC1TY5pcWKrdHnvckBw\iCVVV3PMZRi\2enZDDVUGsyKCi3bnvuc5dvKG:{aXfpckkhc2mwYYPlJIRwdWGrbjDlfJBz\XO|ZXSgbY4hU1K[IHPlcIx{KHW|aX7nJHs{OlCfLXfhcY1iNUGWUDDhcoQhdXmnbHnuJIJie2mlIIDyc5RmcW5ic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhPyCvaX7z MnPDNlYzPzV4OEG=
human NKM-1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGW1WHpKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PjF7NDFOwG0> M4TFTnNCVkeHUh?=
human P30-OHK cell Mn:0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzqNpNzUW6qaXLpeIlwdiCxZjDoeY1idiCSM{CtU2hMKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImsJGlEPTB;MD60PVY2KM7:TR?= NIrsZlVUSU6JRWK=
human YH-13 cell M2\B[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1TtXGlvcGmkaYTpc44hd2ZiaIXtZY4hYUhvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDh6IN88US=> MWjTRW5ITVJ?
human LXF-289 cell NFLQOlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkH5TY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NE43PTZ7MzFOwG0> MVPTRW5ITVJ?
human BE-13 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXriZ4E5UW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB2N{eg{txO MV7TRW5ITVJ?
human RS4-11 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmTXTY5pcWKrdHnvckBw\iCqdX3hckBTWzRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlczPTl2IN88US=> NXHV[XVKW0GQR1XS
human A3-KAW cell M{TmSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGPjVFVKdmirYnn0bY9vKG:oIHj1cYFvKEF|LVvBW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzNyNUWg{txO MkjpV2FPT0WU
human PA-1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmPhTY5pcWKrdHnvckBw\iCqdX3hckBRSS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64NFQzOiEQvF2= MVrTRW5ITVJ?
human ES7 cell NWjqdXd4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MknPTY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkizOVY3KM7:TR?= MX;TRW5ITVJ?
human ES8 cell NXrGfZVqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M162SWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= NXrVd2FkW0GQR1XS
human SW982 cell NXTtPI1xT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4D6SmlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2OTJ2IN88US=> M3LxSHNCVkeHUh?=
human VA-ES-BJ cell M3rG[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2DvO2lvcGmkaYTpc44hd2ZiaIXtZY4hXkFvRWOtRmoh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjl6NE[3JO69VQ>? Mm\RV2FPT0WU
human 697 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVHjWG5{UW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyPjJ|IN88US=> NVrnR5BWW0GQR1XS
human MOLT-4 cell M2jsTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkD1TY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA{OjR2IN88US=> NXnzeYNpW0GQR1XS
human D-283MED cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2rzUGlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|OUS4JO6ddQ>? M2SySHNCVkeHUh?=
human ALL-PO cell M3vDV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVrlNnVDUW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB4MEezJO69VQ>? MXvTRW5ITVJ?
human NB14 cell M4HBeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HNXWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxQDFizszN NWeyeWNNW0GQR1XS
human NTERA-S-cl-D1 cell NVyxSFJVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MofKTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wO|c4PSEQvF2= M{\PeXNCVkeHUh?=
human BFTC-905 cell MmDCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKGi3bXHuJGJHXENvOUC1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xQDFyMTFOwG0> MWTTRW5ITVJ?
human H4 cell NFjROnlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXzJcohq[mm2aX;uJI9nKGi3bXHuJGg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zMEKwNUDPxE1? MmDzV2FPT0WU
human CHP-212 cell MljOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYXJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1ODN5IN88US=> MnHXV2FPT0WU
human A204 cell MoTrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4\1dmlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU1PjdizszN MUjTRW5ITVJ?
human NB69 cell Ml;FS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGToXJBKdmirYnn0bY9vKG:oIHj1cYFvKE6ENkmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE2QDZ3IN88US=> M3vHfnNCVkeHUh?=
human P12-ICHIKAWA cell Mn;jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjxc5Z3UW6qaXLpeIlwdiCxZjDoeY1idiCSMUKtTWNJUUuDV1GgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE5OTdzIN88US=> NVn3ZnBNW0GQR1XS
human L-363 cell Mo\ZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYrCT5F7UW6qaXLpeIlwdiCxZjDoeY1idiCOLUO2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOThzOUeg{txO NGPhbIpUSU6JRWK=
human ES5 cell M3Hsc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1T0WWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPVM2PCEQvF2= M1nrcHNCVkeHUh?=
human CAL-51 cell M2XHWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLJcohq[mm2aX;uJI9nKGi3bXHuJGNCVC13MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlIyPTZizszN M4HyPHNCVkeHUh?=
human NBsusSR cell NIT3d4pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TBVWlvcGmkaYTpc44hd2ZiaIXtZY4hVkK|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjR3N{ig{txO MmPQV2FPT0WU
human HOP-92 cell NFjlTVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\ZVFVKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD25NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd{OUOg{txO M{LIOXNCVkeHUh?=
human DU-4475 cell M3q2UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1jz[WlvcGmkaYTpc44hd2ZiaIXtZY4hTFVvNES3OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjl{NEWg{txO NIrlNXFUSU6JRWK=
human LB1047-RCC cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkixJO69VQ>? MlvMV2FPT0WU
human D-566MG cell NVL0cZBGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF7QZplKdmirYnn0bY9vKG:oIHj1cYFvKERvNU[2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjNyNES4JO69VQ>? MWnTRW5ITVJ?
human A375 cell MoD6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUnYZpQyUW6qaXLpeIlwdiCxZjDoeY1idiCDM{e1JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODh3ODFOwG0> MnTVV2FPT0WU
human ATN-1 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml2xTY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|cyQDVizszN MnfqV2FPT0WU
human M059J cell M1PlWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYLJcohq[mm2aX;uJI9nKGi3bXHuJG0xPTmMIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zO|Y2OiEQvF2= M2\QUnNCVkeHUh?=
human HSC-3 cell M1jkOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mki1TY5pcWKrdHnvckBw\iCqdX3hckBJW0NvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFQzODhizszN MknCV2FPT0WU
human DOHH-2 cell MmjwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFU5OTRizszN NITpTGpUSU6JRWK=
human G-402 cell NX3afpNxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MonRTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFY2OjVizszN MkTGV2FPT0WU
human LC-2-ad cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFz6[pBKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR5MUOyJO69VQ>? MUTTRW5ITVJ?
human LOXIMVI cell NGP4bI1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3TyTGlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTB3NUKg{txO M2rqO3NCVkeHUh?=
human DK-MG cell NVyzOXBRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;YT2lvcGmkaYTpc44hd2ZiaIXtZY4hTEtvTVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4Ojl6IN88US=> M1:0c3NCVkeHUh?=
human HOS cell NX\aUGdWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2L6VmlvcGmkaYTpc44hd2ZiaIXtZY4hUE:VIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|MxQSEQvF2= MmHkV2FPT0WU
human BHT-101 cell MluxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1raSGlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd6N{eg{txO MWrTRW5ITVJ?
human U-2-OS cell NHT3[VZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVizbm1HUW6qaXLpeIlwdiCxZjDoeY1idiCXLUKtU3Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV6OEC2JO69VQ>? NGXsdFFUSU6JRWK=
human D-423MG cell NWrMXW4zT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXrJcohq[mm2aX;uJI9nKGi3bXHuJGQuPDJ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxQDB4IN88US=> Mn3uV2FPT0WU
human AN3-CA cell MoLjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4T5XGlvcGmkaYTpc44hd2ZiaIXtZY4hSU5|LVPBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43Ozl7MTFOwG0> MmnGV2FPT0WU
human TE-11 cell NXi3flZDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXCfGNCUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV{ODFOwG0> MoX3V2FPT0WU
human SK-NEP-1 cell NFrIPGpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M161c2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ3M{e2JO69VQ>? MVLTRW5ITVJ?
human MG-63 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVHLZm5lUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO MXrTRW5ITVJ?
human RH-1 cell M3HIeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NETPdIRKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlcxOjd2IN88US=> MWTTRW5ITVJ?
human MDA-MB-157 cell NIfPPIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXzKVZVWUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTV5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVY4PCEQvF2= NXn5PFZvW0GQR1XS
human A427 cell MnjXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlvJTY5pcWKrdHnvckBw\iCqdX3hckBCPDJ5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63N|U5QSEQvF2= MULTRW5ITVJ?
human ES1 cell NH\UdmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\rbo5KdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|U1PTFizszN MojwV2FPT0WU
human C32 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLJcohq[mm2aX;uJI9nKGi3bXHuJGM{OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{[zPUDPxE1? NGq1c3lUSU6JRWK=
human LAMA-84 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1P0fWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzZ6N{Kg{txO MnPpV2FPT0WU
human YKG-1 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mmr2TY5pcWKrdHnvckBw\iCqdX3hckB[U0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|cyOjRizszN NFfmc2xUSU6JRWK=
human NCI-H1048 cell MmfKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVrvdHZuUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFExPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke4OVA6KM7:TR?= M3zmcHNCVkeHUh?=
human KS-1 cell NH;GfXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP NVHZPFQ4W0GQR1XS
human JVM-3 cell NEXLfmFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;1bHlKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjR7MTFOwG0> MXvTRW5ITVJ?
human GI-ME-N cell M1HObGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEWyNFlKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO MV7TRW5ITVJ?
human GT3TKB cell M2jvVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2G5TWlvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QTZ2MjFOwG0> M4Dv[nNCVkeHUh?=
human CHL-1 cell MknzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGNJVC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT65NlM4QSEQvF2= NGHOPYdUSU6JRWK=
human CHP-134 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYL5e3UyUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVM1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NES2O{DPxE1? MVzTRW5ITVJ?
human 8-MG-BA cell MlzTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYrJcohq[mm2aX;uJI9nKGi3bXHuJFguVUdvQlGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk2PzR2IN88US=> MWfTRW5ITVJ?
human HO-1-N-1 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYHJcohq[mm2aX;uJI9nKGi3bXHuJGhQNTFvTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PzFzNzFOwG0> NXryZVA2W0GQR1XS
human SW1088 cell MofPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXPYPJhYUW6qaXLpeIlwdiCxZjDoeY1idiCVV{GwPFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7NkezJO69VQ>? NUjtOlRoW0GQR1XS
human SW48 cell M{HsPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGTQRmdKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlAzODZ5IN88US=> NIWwZZJUSU6JRWK=
human VM-CUB-1 cell NGXTfYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorCTY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO NWLpN2FNW0GQR1XS
human COLO-800 cell M2j0cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFjoNWxKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? MVzTRW5ITVJ?
human TI-73 cell MmrJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJHRKNTd|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNVM6QSEQvF2= M4rFRXNCVkeHUh?=
human HN cell NXLOd2FlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfoVXhHUW6qaXLpeIlwdiCxZjDoeY1idiCKTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVIyQThizszN M1uyc3NCVkeHUh?=
human DB cell NHfmT|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NI\FPY9KdmirYnn0bY9vKG:oIHj1cYFvKESEIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlY{OSEQvF2= MV\TRW5ITVJ?
human Ca9-22 cell MofrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoTKTY5pcWKrdHnvckBw\iCqdX3hckBE[TlvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEzQDR5IN88US=> MnSzV2FPT0WU
human A549 cell NXTsW|NLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= MUfTRW5ITVJ?
human KGN cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX7UeWZ6UW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=> NVH0OpdUW0GQR1XS
human BCPAP cell NV;3XG5TT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2\ucmlvcGmkaYTpc44hd2ZiaIXtZY4hSkOSQWCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI{OTV6IN88US=> MV;TRW5ITVJ?
human Ramos-2G6-4C10 cell M2fxSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NULRfYpWUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjN5NUmg{txO NFrTZ5FUSU6JRWK=
human OVCAR-5 cell NV\MfWhsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M361T2lvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjd5M{Sg{txO M2nyc3NCVkeHUh?=
human KG-1 cell M3rBWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1;FOWlvcGmkaYTpc44hd2ZiaIXtZY4hU0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlc4QTJizszN NXPVd3k4W0GQR1XS
human CAKI-1 cell NYPZ[oQ4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXvJcohq[mm2aX;uJI9nKGi3bXHuJGNCU0lvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlgxPThizszN MVnTRW5ITVJ?
human QIMR-WIL cell NE\6NmZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvHVWhqUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP MnLYV2FPT0WU
human SW1710 cell NGP1SYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJHNYOTdzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlkyPDJizszN MW\TRW5ITVJ?
human SK-UT-1 cell MlPBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfCdXJbUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OUOzPUDPxE1? MXzTRW5ITVJ?
human IST-SL1 cell NG\SRWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXHJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> M1nMdnNCVkeHUh?=
human SW962 cell MlL6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX\QZY9{UW6qaXLpeIlwdiCxZjDoeY1idiCVV{m2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzN5NUeg{txO NXr0cHE4W0GQR1XS
human EM-2 cell NUXWcXBuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEDEZVRKdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM2OzN5IN88US=> NH\PXFRUSU6JRWK=
human D-263MG cell M4LNOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWPJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjZ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5OzJ5IN88US=> NFfPNYZUSU6JRWK=
human T98G cell M3ewcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmHqTY5pcWKrdHnvckBw\iCqdX3hckBVQTiJIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPFg2PyEQvF2= MX7TRW5ITVJ?
human CTB-1 cell NFzX[oxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPVc3OSEQvF2= NHjUZVdUSU6JRWK=
human Hs-578-T cell M1\VZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13ZN2lvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? Mlf4V2FPT0WU
human SF126 cell M{fwcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfTbYVKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OzZ{MTFOwG0> MVXTRW5ITVJ?
human NCI-H460 cell NXi5W5NTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWjWfY5RUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFQ3OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNEO5OVUh|ryP MXXTRW5ITVJ?
human NCI-H1755 cell Mn7US5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoLKTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV2MESzJO69VQ>? NHniUXhUSU6JRWK=
human HL-60 cell NIrOd4RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1LkTmlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> NGS4VppUSU6JRWK=
human G-401 cell NGjqcXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUTJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDBzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlA6QSEQvF2= M{Dib3NCVkeHUh?=
human AGS cell M4TUUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW\CbWt6UW6qaXLpeIlwdiCxZjDoeY1idiCDR2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3OjV5IN88US=> MnTNV2FPT0WU
human HuO9 cell Ml3qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGh2VzliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2OFU3KM7:TR?= MV;TRW5ITVJ?
human MFE-280 cell MkPlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnKxTY5pcWKrdHnvckBw\iCqdX3hckBOTkVvMkiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjZ6NjFOwG0> NInCZ3hUSU6JRWK=
human NCI-H292 cell Mn2wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVv1WHBiUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFI6OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUe3NlIh|ryP NUjvNIZOW0GQR1XS
human HuO-3N1 cell Mk\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTPe4ZCUW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54MEOwO{DPxE1? M3;zUHNCVkeHUh?=
human ES3 cell NWX1R3VnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3;DfGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62NlI5PSEQvF2= NYLRcIJOW0GQR1XS
human LB2241-RCC cell MnL2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3;V[WlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkmwO|kh|ryP Mn7tV2FPT0WU
human NCI-H1155 cell M1[5UWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1HvXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? NIe5eolUSU6JRWK=
human SW872 cell NVXjfYVmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEXwOXZKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44ODZ5NjFOwG0> MojHV2FPT0WU
human MHH-ES-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmnFTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ4M{Og{txO MkGyV2FPT0WU
human KYSE-150 cell M4riVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELzWFhKdmirYnn0bY9vKG:oIHj1cYFvKEu\U1WtNVUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mkm3JO69VQ>? MnPMV2FPT0WU
human MC-IXC cell M2XPW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NE\GUXVKdmirYnn0bY9vKG:oIHj1cYFvKE2FLVnYR{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl3MzFOwG0> NF7Bd5BUSU6JRWK=
human HCC1187 cell NV\a[ndqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1;s[mlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO M4DafnNCVkeHUh?=
human UMC-11 cell NYPOU3VkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGi3bXHuJHVOSy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVA1PzdizszN NXX6NIp7W0GQR1XS
human NB5 cell Mlu4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NETkeVJKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVM4OTVizszN MmjxV2FPT0WU
human A2058 cell M2W5OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{HvPGlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk4QDR2IN88US=> M1S0dnNCVkeHUh?=
human Becker cell MmnYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkHnTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyOTF{IN88US=> Mnj5V2FPT0WU
human CAS-1 cell MlTiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M37IXGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyPTZ7IN88US=> NYDWZlZNW0GQR1XS
human SW780 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mn;FTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlU3ODlizszN NHm3d2ZUSU6JRWK=
human KM12 cell NWWzcYYyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1\a[mlvcGmkaYTpc44hd2ZiaIXtZY4hU01zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|AyOzJizszN MlvxV2FPT0WU
human PC-3 cell MmHHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4\zUGlvcGmkaYTpc44hd2ZiaIXtZY4hWENvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNVc1OTFizszN M4jWPXNCVkeHUh?=
human A253 cell NXG4T2xDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\vNJVKdmirYnn0bY9vKG:oIHj1cYFvKEF{NUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE5QDl|IN88US=> MXnTRW5ITVJ?
human NB10 cell Mon1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NULHc3RMUW6qaXLpeIlwdiCxZjDoeY1idiCQQkGwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4zOjd5MzFOwG0> NXjlOYxHW0GQR1XS
human A172 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWrJcohq[mm2aX;uJI9nKGi3bXHuJGEyPzJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS0OVch|ryP NHPNPZVUSU6JRWK=
human A498 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HENWlvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOVY{QDNizszN MUDTRW5ITVJ?
human SW1573 cell M1\wTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NES1dWRKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUW3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQTB2OUGg{txO MXXTRW5ITVJ?
human 5637 cell M3Pqbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoDyTY5pcWKrdHnvckBw\iCqdX3hckA2PjN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6wO|kxPCEQvF2= MYnTRW5ITVJ?
human A388 cell MoHBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXPkeJhvUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0> NVvTXpZMW0GQR1XS
human U251 cell MnjMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJHUzPTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{OD6xNVc2KM7:TR?= NXixW3lYW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID