BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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Cited by 31 Publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NFX3NYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJG1XNTRvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zOk45KG6P NHn6bXpUSU6JRWK=
KRX cells Ml7iSpVv[3Srb36gZZN{[Xl? MkfSO{BucW6| M4LzbGlvcGmkaYTpc44hd2ZiU2XNU{11[WepZXSgWWxMOSBqdX7rco94diCxcnnnbY4qKGurbnHz[UBld22jaX6g[ZhxemW|c3XkJIlvKEuUWDDj[YxteyC3c3nu[{BcOzKSXT3nZY1u[S2DVGCgZY5lKG27ZXzpckBj[XOrYzDwdo91\WmwIIP1ZpN1emG2ZTDpcoN2[mG2ZXSg[o9zKDdibXnudy=> MXGyOlI4PTZ6MR?=
human NKM-1 cell M1e4T2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfuWoZKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4{PjF7NDFOwG0> MoPZV2FPT0WU
human P30-OHK cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2HTV2lvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? NWrqbXo3W0GQR1XS
human YH-13 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2jqXWlvcGmkaYTpc44hd2ZiaIXtZY4hYUhvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDh6IN88US=> NXPoOVFFW0GQR1XS
human LXF-289 cell NWLQRndRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU4hUUN3ME2wMlY2Pjl|IN88US=> MUTTRW5ITVJ?
human BE-13 cell M1P6[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nUXWlvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlcxPDd5IN88US=> NFrETGNUSU6JRWK=
human RS4-11 cell NX3kZndHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|I2QTRizszN M2LUdHNCVkeHUh?=
human A3-KAW cell NWO0e2IxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXfJcohq[mm2aX;uJI9nKGi3bXHuJGE{NUuDVzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|MxPTVizszN MnflV2FPT0WU
human PA-1 cell NHjvT|VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?= Mm[2V2FPT0WU
human ES7 cell MkHBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjWSZdKdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFM2PjZizszN M1XUSnNCVkeHUh?=
human ES8 cell NInIUG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3uzNWlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= M1TTeXNCVkeHUh?=
human SW982 cell NXjXSXdzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnyxTY5pcWKrdHnvckBw\iCqdX3hckBUXzl6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVUyOjRizszN NYT0VZl7W0GQR1XS
human VA-ES-BJ cell NV\0eI1XT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIHoWHpKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OES2O{DPxE1? MYTTRW5ITVJ?
human 697 cell NYTuTZU5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mk\qTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCxOlI{KM7:TR?= NHzIe2dUSU6JRWK=
human MOLT-4 cell M13uUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFMzPDRizszN NVjzUVQ2W0GQR1XS
human D-283MED cell NX7NOZVKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXLJcohq[mm2aX;uJI9nKGi3bXHuJGQuOjh|TVXEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xOzl2ODFOoI0> MmT3V2FPT0WU
human ALL-PO cell M3L0cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlG2TY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODd|IN88US=> Mo\6V2FPT0WU
human NB14 cell NVXmSFVLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC2NFgyKM7:TR?= NGG1PGdUSU6JRWK=
human NTERA-S-cl-D1 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV\xU|BIUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPzd5NTFOwG0> M1\2U3NCVkeHUh?=
human BFTC-905 cell NIrtU2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELuWGFKdmirYnn0bY9vKG:oIHj1cYFvKEKIVFOtPVA2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yOEGwNUDPxE1? NYD2WYpGW0GQR1XS
human H4 cell M2LvUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2jsU2lvcGmkaYTpc44hd2ZiaIXtZY4hUDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkGwNlAyKM7:TR?= M2\IbHNCVkeHUh?=
human CHP-212 cell NFSwcopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjVTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMkGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPDB|NzFOwG0> M1nafHNCVkeHUh?=
human A204 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{K2[GlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU1PjdizszN MoLZV2FPT0WU
human NB69 cell M1LwNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1PPT2lvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU5PjVizszN MUXTRW5ITVJ?
human P12-ICHIKAWA cell MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUixO|Eh|ryP M1zJZXNCVkeHUh?=
human L-363 cell NEHkOHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE6PyEQvF2= NWjLRogxW0GQR1XS
human ES5 cell M3fBZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIXrc4FKdmirYnn0bY9vKG:oIHj1cYFvKEWVNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVk{PTRizszN NXzNO4F6W0GQR1XS
human CAL-51 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEPSTIRKdmirYnn0bY9vKG:oIHj1cYFvKEODTD21NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjJzNU[g{txO NVTxW|ltW0GQR1XS
human NBsusSR cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVfJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI1PTd6IN88US=> MlWwV2FPT0WU
human HOP-92 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXHCb414UW6qaXLpeIlwdiCxZjDoeY1idiCKT2CtPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ5MkmzJO69VQ>? MVXTRW5ITVJ?
human DU-4475 cell NV;NdHFrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\PTHVXUW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK0OUDPxE1? NH;sUIVUSU6JRWK=
human LB1047-RCC cell M4TLWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfUTY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK4NUDPxE1? MlLTV2FPT0WU
human D-566MG cell NWTDV5pzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml7UTY5pcWKrdHnvckBw\iCqdX3hckBFNTV4Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{ODR2ODFOwG0> MoW3V2FPT0WU
human A375 cell NHzXSFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2fqVGlvcGmkaYTpc44hd2ZiaIXtZY4hSTN5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|A5PThizszN M3;MXHNCVkeHUh?=
human ATN-1 cell MnrvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX;uclU4UW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzdzOEWg{txO MUPTRW5ITVJ?
human M059J cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUW2ZnM1UW6qaXLpeIlwdiCxZjDoeY1idiCPMEW5TkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzd4NUKg{txO NWLXOG5DW0GQR1XS
human HSC-3 cell Mli4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1[4b2lvcGmkaYTpc44hd2ZiaIXtZY4hUFOFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1OjB6IN88US=> MX\TRW5ITVJ?
human DOHH-2 cell MmXqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFSzc3hKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDV6MUSg{txO NU\rd|MyW0GQR1XS
human G-402 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnPwTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFY2OjVizszN M3e0XnNCVkeHUh?=
human LC-2-ad cell MofsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGxENTJvYXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ4OTN{IN88US=> MoHGV2FPT0WU
human LOXIMVI cell NHjwNZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYWz[3Q1UW6qaXLpeIlwdiCxZjDoeY1idiCOT2jJUXZKKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53MEW1NkDPxE1? MYHTRW5ITVJ?
human DK-MG cell M1HpfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MULJcohq[mm2aX;uJI9nKGi3bXHuJGRMNU2JIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|I6QCEQvF2= NVHWW5B7W0GQR1XS
human HOS cell NYG0doptT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVLoT3VlUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4OzB7IN88US=> M{jQRnNCVkeHUh?=
human BHT-101 cell M{XGdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HkcWlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd6N{eg{txO NXLkUGdKW0GQR1XS
human U-2-OS cell NUm5SldtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlWzTY5pcWKrdHnvckBw\iCqdX3hckBWNTJvT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU5QDB4IN88US=> NEDrNpJUSU6JRWK=
human D-423MG cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXzJcohq[mm2aX;uJI9nKGi3bXHuJGQuPDJ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxQDB4IN88US=> MmLEV2FPT0WU
human AN3-CA cell Mm\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVPpN5lyUW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ|OUmxJO69VQ>? NEL5TmtUSU6JRWK=
human TE-11 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUPIfmxtUW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV{ODFOwG0> NHX4bVhUSU6JRWK=
human SK-NEP-1 cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWXJcohq[mm2aX;uJI9nKGi3bXHuJHNMNU6HUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PTN5NjFOwG0> NHrVZmxUSU6JRWK=
human MG-63 cell MlXVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mm[wTY5pcWKrdHnvckBw\iCqdX3hckBOTy14MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlg2PjdizszN MoTjV2FPT0WU
human RH-1 cell Mn\IS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYf6b5g1UW6qaXLpeIlwdiCxZjDoeY1idiCUSD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44ODJ5NDFOwG0> M2Pu[3NCVkeHUh?=
human MDA-MB-157 cell NGnkU4RIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2xOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjdzNke0JO69VQ>? MWrTRW5ITVJ?
human A427 cell NIS0PVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOVg6KM7:TR?= Ml\WV2FPT0WU
human ES1 cell NIXYfHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJGVUOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{W0OVEh|ryP NYrlVFRyW0GQR1XS
human C32 cell NXK2XpRjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{nKdWlvcGmkaYTpc44hd2ZiaIXtZY4hSzN{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OlM6KM7:TR?= NFf2emlUSU6JRWK=
human LAMA-84 cell M{\obmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH;q[oJKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd4OEeyJO69VQ>? MXrTRW5ITVJ?
human YKG-1 cell Mn\uS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3G2NmlvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTJ2IN88US=> NVjB[mw2W0GQR1XS
human NCI-H1048 cell MonNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\TT5lKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVA1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{i1NFkh|ryP M3fROnNCVkeHUh?=
human KS-1 cell NG[zR5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXxOFdpUW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45Ojl6IN88US=> NIPKc5BUSU6JRWK=
human JVM-3 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoPmTY5pcWKrdHnvckBw\iCqdX3hckBLXk1vMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFY1QTFizszN NVL2cHlmW0GQR1XS
human GI-ME-N cell M{njcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHLhc4VKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO M4XzXXNCVkeHUh?=
human GT3TKB cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJGdVO1SNQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFk3PDJizszN MnG1V2FPT0WU
human CHL-1 cell NVvFe4NZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1[zWGlvcGmkaYTpc44hd2ZiaIXtZY4hS0iOLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlkzOzd7IN88US=> NH;DTIhUSU6JRWK=
human CHP-134 cell NHrs[YhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH[zWJhKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2xN|Qh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl2NE[3JO69VQ>? NH\uWYpUSU6JRWK=
human 8-MG-BA cell NX3YUG5vT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIi3T2pKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl3N{S0JO69VQ>? MmLEV2FPT0WU
human HO-1-N-1 cell NVOyemJ5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGHQ[G5KdmirYnn0bY9vKG:oIHj1cYFvKEiRLUGtUk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{GxO{DPxE1? Mn[3V2FPT0WU
human SW1088 cell MoPqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1HaZmlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzMEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46QTZ5MzFOwG0> NHn2OJdUSU6JRWK=
human SW48 cell NV\xT4NZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGOyO2JKdmirYnn0bY9vKG:oIHj1cYFvKFOZNEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlAzODZ5IN88US=> NVKwbnR{W0GQR1XS
human VM-CUB-1 cell NFWyUlFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{\3XmlvcGmkaYTpc44hd2ZiaIXtZY4hXk1vQ2XCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB2MUG5JO69VQ>? MXTTRW5ITVJ?
human COLO-800 cell MlTHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlHCTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRLUiwNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODVzM{[g{txO M3f4cnNCVkeHUh?=
human TI-73 cell MnPwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnLVIJKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOTN7OTFOwG0> M4LmN3NCVkeHUh?=
human HN cell NGfGfGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHHkWIlKdmirYnn0bY9vKG:oIHj1cYFvKEiQIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlE6QCEQvF2= NITWVpVUSU6JRWK=
human DB cell NVrQRlZQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2WyPGlvcGmkaYTpc44hd2ZiaIXtZY4hTEJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyOlMyKM7:TR?= NXnjTIlrW0GQR1XS
human Ca9-22 cell NF21To5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGPISYVKdmirYnn0bY9vKG:oIHj1cYFvKEOjOT2yNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOTJ6NEeg{txO NHHPd|dUSU6JRWK=
human A549 cell M1u4bmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVfJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= MVzTRW5ITVJ?
human KGN cell NGju[mFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\0TY5pcWKrdHnvckBw\iCqdX3hckBMT05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkKyOVk2KM7:TR?= MUTTRW5ITVJ?
human BCPAP cell NWrz[ohDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGJEWEGSIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yN|E2QCEQvF2= Ml3jV2FPT0WU
human Ramos-2G6-4C10 cell M4LTNGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYDJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yN|c2QSEQvF2= NYPXOGpvW0GQR1XS
human OVCAR-5 cell M1LLT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mkf0TY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd|NDFOwG0> MUjTRW5ITVJ?
human KG-1 cell M3uycmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2XIb2lvcGmkaYTpc44hd2ZiaIXtZY4hU0dvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlc4QTJizszN MlnOV2FPT0WU
human CAKI-1 cell NGTmeFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEDFWZFKdmirYnn0bY9vKG:oIHj1cYFvKEODS1mtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjhyNUig{txO MmPsV2FPT0WU
human QIMR-WIL cell NYWwN|VNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jZbGlvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6N{S0JO69VQ>? NH:zfppUSU6JRWK=
human SW1710 cell NFKwS2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUXaUJV2UW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3NVAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ7MUSyJO69VQ>? MlnuV2FPT0WU
human SK-UT-1 cell NVLFZllZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHNMNVWWLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OzN7IN88US=> M4TPeXNCVkeHUh?=
human IST-SL1 cell MoTwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1TMSGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzJzN{Sg{txO NYOzdHBPW0GQR1XS
human SW962 cell M3fQcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{DPS2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d7NkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM{PzV5IN88US=> NHzLRm1USU6JRWK=
human EM-2 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWfJcohq[mm2aX;uJI9nKGi3bXHuJGVONTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkO1N|M4KM7:TR?= MoGyV2FPT0WU
human D-263MG cell NIP0U4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2HaZmlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzh|Mkeg{txO MoP2V2FPT0WU
human T98G cell NH6zXINIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3foSGlvcGmkaYTpc44hd2ZiaIXtZY4hXDl6RzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|g5PTdizszN NHfpOXlUSU6JRWK=
human CTB-1 cell NET3NYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn;STY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN MWLTRW5ITVJ?
human Hs-578-T cell M3HnZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYTJcohq[mm2aX;uJI9nKGi3bXHuJGh{NTV5OD3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OTV6NzFOwG0> M2KzRnNCVkeHUh?=
human SF126 cell MVrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX\Mc|dTUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO NGLzSpFUSU6JRWK=
human NCI-H460 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{C3N2lvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi0OlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjR|OUW1JO69VQ>? M3i0VXNCVkeHUh?=
human NCI-H1755 cell M{W2[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MY\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRyNEOg{txO NIf3XlJUSU6JRWK=
human HL-60 cell NUXSdJZbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3H4TmlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> NIK4eYpUSU6JRWK=
human G-401 cell NX[0SZpvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDBzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlA6QSEQvF2= NGOyVXdUSU6JRWK=
human AGS cell M2PRTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jkeGlvcGmkaYTpc44hd2ZiaIXtZY4hSUeVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlI2PyEQvF2= NHi4SnhUSU6JRWK=
human HuO9 cell MkXZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NULP[HJ6UW6qaXLpeIlwdiCxZjDoeY1idiCKdV:5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PjR3NjFOwG0> Ml7ZV2FPT0WU
human MFE-280 cell NF7WcoNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUHJcohq[mm2aX;uJI9nKGi3bXHuJG1HTS1{OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3Pjh4IN88US=> M4\uOnNCVkeHUh?=
human NCI-H292 cell MlPPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHnGWJVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53N{eyNkDPxE1? NFn5OlFUSU6JRWK=
human HuO-3N1 cell NHTueYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYDIW2J[UW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54MEOwO{DPxE1? MV7TRW5ITVJ?
human ES3 cell NHjl[|BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUf5bWJpUW6qaXLpeIlwdiCxZjDoeY1idiCHU{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYzOjh3IN88US=> M4DM[XNCVkeHUh?=
human LB2241-RCC cell NVvQWpdpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFzFfZBKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5NFc6KM7:TR?= MoDwV2FPT0WU
human NCI-H1155 cell NW\jeZBiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUPKPZVGUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5OFA2KM7:TR?= MXnTRW5ITVJ?
human SW872 cell M{W5eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEL3ZWxKdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44ODZ5NjFOwG0> MXvTRW5ITVJ?
human MHH-ES-1 cell M3PMb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIr0bnVKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mk[zN{DPxE1? M4r5[XNCVkeHUh?=
human KYSE-150 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVPYXlhJUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVE2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K5O{DPxE1? MX\TRW5ITVJ?
human MC-IXC cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;QTY5pcWKrdHnvckBw\iCqdX3hckBOSy2LWFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6PTNizszN MkG2V2FPT0WU
human HCC1187 cell NE\ubJFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVvs[Hp4UW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxNVg4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi56OU[3O{DPxE1? Mn;OV2FPT0WU
human UMC-11 cell NW\TenRkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXq1XI5KUW6qaXLpeIlwdiCxZjDoeY1idiCXTVOtNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjlyNEe3JO69VQ>? MV\TRW5ITVJ?
human NB5 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkO0TY5pcWKrdHnvckBw\iCqdX3hckBPSjViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkmzO|E2KM7:TR?= Ml\6V2FPT0WU
human A2058 cell NHrxb4NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NULWNItxUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC1PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTd6NESg{txO NEPIcpdUSU6JRWK=
human Becker cell NXT0e2xsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{jM[2lvcGmkaYTpc44hd2ZiaIXtZY4hSmWla3XyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTFzMjFOwG0> M{TCdnNCVkeHUh?=
human CAS-1 cell M1ezN2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVexd29EUW6qaXLpeIlwdiCxZjDoeY1idiCFQWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODF3Nkmg{txO MmHNV2FPT0WU
human SW780 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjyTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlU3ODlizszN MWDTRW5ITVJ?
human KM12 cell M3PrOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlPDTY5pcWKrdHnvckBw\iCqdX3hckBMVTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zNFE{OiEQvF2= MVrTRW5ITVJ?
human PC-3 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHF[41KdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE4PDFzIN88US=> Mle2V2FPT0WU
human A253 cell M2DkU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXjxXVduUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> NWjEOoJ2W0GQR1XS
human NB10 cell M2iwTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13CeGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNlI4PzNizszN NVH3N4E{W0GQR1XS
human A172 cell M3XVeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGf0[mZKdmirYnn0bY9vKG:oIHj1cYFvKEFzN{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ1PTdizszN NEXVUIpUSU6JRWK=
human A498 cell M4L0W2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M17BUGlvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOVY{QDNizszN M4jTdnNCVkeHUh?=
human SW1573 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3X4UWlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzNUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok46ODR7MTFOwG0> NX:zb5ZtW0GQR1XS
human 5637 cell M{C2d2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYrJcohq[mm2aX;uJI9nKGi3bXHuJFU3OzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkC3PVA1KM7:TR?= NUT5TY5GW0GQR1XS
human A388 cell NVqybnRET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV;CfZdRUW6qaXLpeIlwdiCxZjDoeY1idiCDM{i4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlEvOTN7ODFOwG0> MUDTRW5ITVJ?
human U251 cell MmnkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rkXGlvcGmkaYTpc44hd2ZiaIXtZY4hXTJ3MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK4MlEyPzVizszN MnnZV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
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  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID