BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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Cited by 27 Publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NUK5TW9sT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\HTnpKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Pi56IH7N MWjTRW5ITVJ?
KRX cells NYiwVJNMTnWwY4Tpc44h[XO|YYm= MnH3O{BucW6| NGnXRYVKdmirYnn0bY9vKG:oIGPVUW8ufGGpZ3XkJHVNUzFiKIXub45wf25ib4Lp[4lvMSCtaX7hd4Uh\G:vYXnuJIV5eHKnc4Pl[EBqdiCNUmigZ4VtdHNidYPpcochYzN{UG2t[4FudWFvQWTQJIFv\CCveXXsbY4h[mG|aXOgdJJwfGWrbjDzeYJ{fHKjdHWgbY5kfWKjdHXkJIZweiB5IH3pcpM> MUeyOlI4PTZ6MR?=
human NKM-1 cell NIPU[ZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYm0clA6UW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzZzOUSg{txO NVjlVGh6W0GQR1XS
human P30-OHK cell NWTXdWxMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHPGfWNKdmirYnn0bY9vKG:oIHj1cYFvKFB|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTygTWM2OD1yLkS5OlUh|ryP NWLwTnJOW0GQR1XS
human YH-13 cell NGnuc|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXkfmVKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE43Ojh6ODFOwG0> M{D2THNCVkeHUh?=
human LXF-289 cell NFjNPZZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mo\vTY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NE43PTZ7MzFOwG0> NEnZWHlUSU6JRWK=
human BE-13 cell NUDYdIFkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVKyOm9XUW6qaXLpeIlwdiCxZjDoeY1idiCERT2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzB2N{eg{txO M2m0SHNCVkeHUh?=
human RS4-11 cell NYLGcIpOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYPJcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|I2QTRizszN M{DSdXNCVkeHUh?=
human A3-KAW cell MnniS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjFeXRKdmirYnn0bY9vKG:oIHj1cYFvKEF|LVvBW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzNyNUWg{txO NV\QOlNWW0GQR1XS
human PA-1 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVq1OGxrUW6qaXLpeIlwdiCxZjDoeY1idiCSQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45ODR{MjFOwG0> MojzV2FPT0WU
human ES7 cell MoDxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1[0emlvcGmkaYTpc44hd2ZiaIXtZY4hTVN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64N|U3PiEQvF2= NEHJT3lUSU6JRWK=
human ES8 cell MoO3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDYW2pKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFQ{OzZizszN NVjoTmZUW0GQR1XS
human SW982 cell MnztS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlrMTY5pcWKrdHnvckBw\iCqdX3hckBUXzl6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVUyOjRizszN MkPxV2FPT0WU
human VA-ES-BJ cell M2PwdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXro[|l7UW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUi0Olch|ryP M37Bc3NCVkeHUh?=
human 697 cell NH6yZ3VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkPpTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkCxOlI{KM7:TR?= NGH2T5ZUSU6JRWK=
human MOLT-4 cell NHHLUmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3PTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA{OjR2IN88US=> NGTDZYtUSU6JRWK=
human D-283MED cell NFHMfIxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NE[xfmZKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yM{m0PEDPpG1? NY[3[WtXW0GQR1XS
human ALL-PO cell NITV[WZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxPzNizszN MoLUV2FPT0WU
human NB14 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1z5OWlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFYxQDFizszN NIrxW5NUSU6JRWK=
human NTERA-S-cl-D1 cell MkfCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3nRTmlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFc4PzVizszN Mmj0V2FPT0WU
human BFTC-905 cell NYjnT4xiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnzwTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO MWfTRW5ITVJ?
human H4 cell MmTqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4T1[2lvcGmkaYTpc44hd2ZiaIXtZY4hUDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkGwNlAyKM7:TR?= MWjTRW5ITVJ?
human CHP-212 cell NVKweGZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{\wfWlvcGmkaYTpc44hd2ZiaIXtZY4hS0iSLUKxNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOTRyM{eg{txO NEnsWZlUSU6JRWK=
human A204 cell NIjnRoJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DOWmlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU1PjdizszN MVnTRW5ITVJ?
human NB69 cell MmXYS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkXKTY5pcWKrdHnvckBw\iCqdX3hckBPSjZ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVg3PSEQvF2= MVXTRW5ITVJ?
human P12-ICHIKAWA cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUixO|Eh|ryP NGLPZ3NUSU6JRWK=
human L-363 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjYTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyQTdizszN NUnHXoRYW0GQR1XS
human ES5 cell NXiwXG9xT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1Hle2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPVM2PCEQvF2= NFnMNpRUSU6JRWK=
human CAL-51 cell MlfLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXfLZm1vUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? NUfoV2xmW0GQR1XS
human NBsusSR cell M1ztU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkK3TY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> NE\mUIxUSU6JRWK=
human HOP-92 cell Mm\DS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYTJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC17MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlczQTNizszN NVvhOoh4W0GQR1XS
human DU-4475 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;yR2Q3UW6qaXLpeIlwdiCxZjDoeY1idiCGVT20OFc2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK0OUDPxE1? M4PCPXNCVkeHUh?=
human LB1047-RCC cell MlLyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjoTY5pcWKrdHnvckBw\iCqdX3hckBNSjFyNEetVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5{OUK4NUDPxE1? M324[XNCVkeHUh?=
human D-566MG cell M1:4XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUHKcY4{UW6qaXLpeIlwdiCxZjDoeY1idiCGLUW2Om1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|MES0PEDPxE1? NGr3NoZUSU6JRWK=
human A375 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{XwU2lvcGmkaYTpc44hd2ZiaIXtZY4hSTN5NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|A5PThizszN M4\QNnNCVkeHUh?=
human ATN-1 cell MnjHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlj4TY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|cyQDVizszN NXjUVJBtW0GQR1XS
human M059J cell NGjHUZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{jSUGlvcGmkaYTpc44hd2ZiaIXtZY4hVTB3OVqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4PjV{IN88US=> NWfIXG1FW0GQR1XS
human HSC-3 cell Ml7sS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGhUSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OFIxQCEQvF2= M4DWRXNCVkeHUh?=
human DOHH-2 cell M4jsfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3n4TmlvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PThzNDFOwG0> M1;yPHNCVkeHUh?=
human G-402 cell MoSxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV\iNXpCUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDZ3MkWg{txO MoDnV2FPT0WU
human LC-2-ad cell MmfmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3TMc2lvcGmkaYTpc44hd2ZiaIXtZY4hVENvMj3h[EBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDdzM{Kg{txO MVzTRW5ITVJ?
human LOXIMVI cell NHnEdWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGnTR|dKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>? NFvNTo5USU6JRWK=
human DK-MG cell M2TDUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{LTbGlvcGmkaYTpc44hd2ZiaIXtZY4hTEtvTVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4Ojl6IN88US=> MY\TRW5ITVJ?
human HOS cell NXzndXlkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIO3VotKdmirYnn0bY9vKG:oIHj1cYFvKEiRUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVc{ODlizszN MY\TRW5ITVJ?
human BHT-101 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2TycGlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd6N{eg{txO NEPZWoJUSU6JRWK=
human U-2-OS cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmL5TY5pcWKrdHnvckBw\iCqdX3hckBWNTJvT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU5QDB4IN88US=> NFXJb3VUSU6JRWK=
human D-423MG cell NEDFXHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGQuPDJ|TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlYxQDB4IN88US=> NUHjO4ZvW0GQR1XS
human AN3-CA cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLRNpBKdmirYnn0bY9vKG:oIHj1cYFvKEGQMz3DRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjN7OUGg{txO MmH0V2FPT0WU
human TE-11 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OVI5KM7:TR?= MkLZV2FPT0WU
human SK-NEP-1 cell M17ofWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4rXWmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ3M{e2JO69VQ>? NETJUZNUSU6JRWK=
human MG-63 cell NV6zbVBbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUfTe2oxUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO NFPSTpdUSU6JRWK=
human RH-1 cell MoHiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NE\iPYpKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlcxOjd2IN88US=> M2Dwc3NCVkeHUh?=
human MDA-MB-157 cell M4nmb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXrJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2xOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjdzNke0JO69VQ>? NFfaOYhUSU6JRWK=
human A427 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGnxWJdKdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{PTh7IN88US=> NUDFPGlOW0GQR1XS
human ES1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4nXb2lvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OVQ2OSEQvF2= M1jxdHNCVkeHUh?=
human C32 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnmzTY5pcWKrdHnvckBw\iCqdX3hckBEOzJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke2N|kh|ryP NIHDU2JUSU6JRWK=
human LAMA-84 cell MmrGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYLOU5JiUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? NHznRZJUSU6JRWK=
human YKG-1 cell NFnnfVhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4fI[WlvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTJ2IN88US=> M4Dj[XNCVkeHUh?=
human NCI-H1048 cell NFXsdYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEKzd5FKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVA1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{i1NFkh|ryP MmjtV2FPT0WU
human KS-1 cell MlL6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYnJcohq[mm2aX;uJI9nKGi3bXHuJGtUNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkiyPVgh|ryP NUXzWVg4W0GQR1XS
human JVM-3 cell NIPFS4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFPZ[ohKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjR7MTFOwG0> NF70WoJUSU6JRWK=
human GI-ME-N cell MkftS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mk[0TY5pcWKrdHnvckBw\iCqdX3hckBIUS2PRT3OJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjV|IN88US=> NHTD[2JUSU6JRWK=
human GT3TKB cell NUPxXJFqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnzhTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg6PjR{IN88US=> Mne1V2FPT0WU
human CHL-1 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGNJVC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT65NlM4QSEQvF2= M1[wSXNCVkeHUh?=
human CHP-134 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1zM{SgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlk1PDZ5IN88US=> MUTTRW5ITVJ?
human 8-MG-BA cell NH:0PIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXzxO21TUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1? M1nSc3NCVkeHUh?=
human HO-1-N-1 cell NGjvdHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3uTY5pcWKrdHnvckBw\iCqdX3hckBJVy1zLV6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTdzMUeg{txO Mnz4V2FPT0WU
human SW1088 cell M4Hoc2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3tTXl7UW6qaXLpeIlwdiCxZjDoeY1idiCVV{GwPFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7NkezJO69VQ>? MULTRW5ITVJ?
human SW48 cell M2CzUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3G5b2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d2ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFIxPjdizszN MX7TRW5ITVJ?
human VM-CUB-1 cell NGnGeFJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXLjWVJYUW6qaXLpeIlwdiCxZjDoeY1idiCYTT3DWWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMESxNVkh|ryP NEH6cVlUSU6JRWK=
human COLO-800 cell M{PnVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NELUd5dKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? MlriV2FPT0WU
human TI-73 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHW5[JFKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOTN7OTFOwG0> M3LQfXNCVkeHUh?=
human HN cell M4\zbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{\KWmlvcGmkaYTpc44hd2ZiaIXtZY4hUE5iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNVk5KM7:TR?= MoTyV2FPT0WU
human DB cell M1LWTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF\VPJRKdmirYnn0bY9vKG:oIHj1cYFvKESEIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNlY{OSEQvF2= M4fEeHNCVkeHUh?=
human Ca9-22 cell MnnuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2f1NWlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> MUfTRW5ITVJ?
human A549 cell NWnwUHdPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M37RN2lvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVM5ODhizszN M3jN[HNCVkeHUh?=
human KGN cell NUDWXmptT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYDFdYtKUW6qaXLpeIlwdiCxZjDoeY1idiCNR16gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlIzPTl3IN88US=> M3THcHNCVkeHUh?=
human BCPAP cell NFjzTGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoTrTY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN NEHRd|BUSU6JRWK=
human Ramos-2G6-4C10 cell NHXqNVJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yN|c2QSEQvF2= MkHmV2FPT0WU
human OVCAR-5 cell MnPjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4PzN2IN88US=> NVTFUZlWW0GQR1XS
human KG-1 cell MmLLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI[0UnJKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4Pzl{IN88US=> MV;TRW5ITVJ?
human CAKI-1 cell Moi0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\s[2lvcGmkaYTpc44hd2ZiaIXtZY4hS0GNST2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQDB3ODFOwG0> Mmq1V2FPT0WU
human QIMR-WIL cell NHTJT41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHFKVVJvV1nMJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQDd2NDFOwG0> NYm3[Y5GW0GQR1XS
human SW1710 cell M3TOWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnzwTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=> MnrzV2FPT0WU
human SK-UT-1 cell M4rxOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4C0[WlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjl|M{mg{txO Ml:1V2FPT0WU
human IST-SL1 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH;TSodKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjN{MUe0JO69VQ>? NEDtR4FUSU6JRWK=
human SW962 cell NUfX[nhET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mo\LTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|M4PTdizszN NEDtT3VUSU6JRWK=
human EM-2 cell NVL4N2MzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NW\UUpZ5UW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{PTN|NzFOwG0> NGmx[G1USU6JRWK=
human D-263MG cell M4LWVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXHB[GhDUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK2N21IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5|OEOyO{DPxE1? NUPiWYRiW0GQR1XS
human T98G cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUHUeIgyUW6qaXLpeIlwdiCxZjDoeY1idiCWOUjHJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{QDh3NzFOwG0> NIS0[pNUSU6JRWK=
human CTB-1 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2jI[GlvcGmkaYTpc44hd2ZiaIXtZY4hS1SELUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM6PzZzIN88US=> MYDTRW5ITVJ?
human Hs-578-T cell NYe2NJFzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnjwTY5pcWKrdHnvckBw\iCqdX3hckBJey13N{itWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDF3OEeg{txO MlvjV2FPT0WU
human SF126 cell NIHMR2hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2DTPWlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ{PjJzIN88US=> MX3TRW5ITVJ?
human NCI-H460 cell NIG4VWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> MlHVV2FPT0WU
human NCI-H1755 cell M4H6NGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1naPGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixO|U2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53NEC0N{DPxE1? M4OyRXNCVkeHUh?=
human HL-60 cell MmnUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjENnV6UW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRzNUmg{txO NWrTd5FGW0GQR1XS
human G-401 cell NY[1TXJ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4XiPGlvcGmkaYTpc44hd2ZiaIXtZY4hTy12MEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3ODl7IN88US=> NVPqTmpFW0GQR1XS
human AGS cell NFi2UYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1LmeWlvcGmkaYTpc44hd2ZiaIXtZY4hSUeVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlI2PyEQvF2= M1\2[XNCVkeHUh?=
human HuO9 cell M3fVWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHv0eVNKdmirYnn0bY9vKG:oIHj1cYFvKEi3T{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3PDV4IN88US=> MUXTRW5ITVJ?
human MFE-280 cell NXTFWldIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXL5Xoc3UW6qaXLpeIlwdiCxZjDoeY1idiCPRlWtNlgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53Nk[4OkDPxE1? MULTRW5ITVJ?
human NCI-H292 cell NFm1eWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLHTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTd5MkKg{txO MVvTRW5ITVJ?
human HuO-3N1 cell NWPoPJczT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1yyfWlvcGmkaYTpc44hd2ZiaIXtZY4hUHWRLUPONUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjB|MEeg{txO M2DVPHNCVkeHUh?=
human ES3 cell M4DOU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVjJcohq[mm2aX;uJI9nKGi3bXHuJGVUOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkKyPFUh|ryP NV3MeJZ{W0GQR1XS
human LB2241-RCC cell NVXyVmpIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHXQ[mRKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5NFc6KM7:TR?= NEnzeI5USU6JRWK=
human NCI-H1155 cell NHzFNndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{PiRWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? MojKV2FPT0WU
human SW872 cell M1TxUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj63NFY4PiEQvF2= NFLDToZUSU6JRWK=
human MHH-ES-1 cell NVXKfolqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlS5TY5pcWKrdHnvckBw\iCqdX3hckBOUEhvRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ4M{Og{txO MXTTRW5ITVJ?
human KYSE-150 cell NUW1e4E1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MojCTY5pcWKrdHnvckBw\iCqdX3hckBMYVOHLUG1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ7NzFOwG0> NX3HclZvW0GQR1XS
human MC-IXC cell NEHxSGZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn3oTY5pcWKrdHnvckBw\iCqdX3hckBOSy2LWFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6PTNizszN NU\vSI54W0GQR1XS
human HCC1187 cell NYnXRmNtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYjJcohq[mm2aX;uJI9nKGi3bXHuJGhESzFzOEegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlg6Pjd5IN88US=> M{Hw[XNCVkeHUh?=
human UMC-11 cell MnLkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJHVOSy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVA1PzdizszN NH3ZRYRUSU6JRWK=
human NB5 cell M2Pnfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NU\q[mxzUW6qaXLpeIlwdiCxZjDoeY1idiCQQkWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk{PzF3IN88US=> NETMVI5USU6JRWK=
human A2058 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUnnWoFTUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC1PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTd6NESg{txO NWTjOlg2W0GQR1XS
human Becker cell NXjvbJRyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFvtWHJKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO NV34SoVuW0GQR1XS
human CAS-1 cell M4W5UGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJGNCWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wNVU3QSEQvF2= M372N3NCVkeHUh?=
human SW780 cell M160PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFv1[nRKdmirYnn0bY9vKG:oIHj1cYFvKFOZN{iwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zPTZyOTFOwG0> M3:3RXNCVkeHUh?=
human KM12 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1yzOGlvcGmkaYTpc44hd2ZiaIXtZY4hU01zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|AyOzJizszN NFrXRWVUSU6JRWK=
human PC-3 cell MmXES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkD6TY5pcWKrdHnvckBw\iCqdX3hckBRSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xO|QyOSEQvF2= M2rIRnNCVkeHUh?=
human A253 cell M4f6SWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnn1TY5pcWKrdHnvckBw\iCqdX3hckBCOjV|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xPFg6OyEQvF2= MVHTRW5ITVJ?
human NB10 cell NXfFNnBIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzqNIpKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPzd|IN88US=> Mne1V2FPT0WU
human A172 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NET2OWFKdmirYnn0bY9vKG:oIHj1cYFvKEFzN{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ1PTdizszN NEjGO4hUSU6JRWK=
human A498 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUjJcohq[mm2aX;uJI9nKGi3bXHuJGE1QThiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkW2N|g{KM7:TR?= MY\TRW5ITVJ?
human SW1573 cell MoCyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUHwcFVLUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G1O|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjlyNEmxJO69VQ>? Mkf6V2FPT0WU
human 5637 cell NXHYd4RbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVvVR3lIUW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> MUjTRW5ITVJ?
human A388 cell NV2yWFFbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{PPV2lvcGmkaYTpc44hd2ZiaIXtZY4hSTN6ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKxMlE{QThizszN NHXBNXNUSU6JRWK=
human U251 cell MoDnS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGLIOXBKdmirYnn0bY9vKG:oIHj1cYFvKFV{NUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPE4yOTd3IN88US=> NI\ERXhUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
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  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID