BX-795

For research use only.

Catalog No.S1274

36 publications

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1.

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Selleck's BX-795 has been cited by 36 publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MlHPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MknOTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= NGrseJFUSU6JRWK=
KRX cells NV\OdlZzTnWwY4Tpc44h[XO|YYm= M{e5WFchdWmwcx?= MXLJcohq[mm2aX;uJI9nKFOXTV:teIFo\2WmIGXMT|EhMHWwa37ve44hd3KrZ3nuLUBscW6jc3Wg[I9u[WmwIHX4dJJme3OnZDDpckBMWlhiY3XscJMhfXOrbnegX|MzWF1vZ3HtcYEuSVSSIHHu[EBugWWuaX6gZoF{cWNicILveIVqdiC|dXLzeJJifGViaX7jeYJifGWmIH\vdkA4KG2rboO= M3\1b|I3Ojd3Nkix
human NKM-1 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVzvcFNoUW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzZzOUSg{txO M3jPTnNCVkeHUh?=
human P30-OHK cell NH\xNWdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlzlTY5pcWKrdHnvckBw\iCqdX3hckBROzBvT1jLJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHluIFnDOVA:OC52OU[1JO69VQ>? MoXDV2FPT0WU
human YH-13 cell NGXQZWJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1:2U2lvcGmkaYTpc44hd2ZiaIXtZY4hYUhvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlYzQDh6IN88US=> NVvV[mpXW0GQR1XS
human LXF-289 cell Mlu5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEjqO2RKdmirYnn0bY9vKG:oIHj1cYFvKEy[Rj2yPFkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigS5iSVO1NF0xNjZ3NkmzJO69VQ>? MXLTRW5ITVJ?
human BE-13 cell MnjlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{HON2lvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlcxPDd5IN88US=> MnzaV2FPT0WU
human RS4-11 cell NXyxWZRZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4ntXGlvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OjV7NDFOwG0> M2jFS3NCVkeHUh?=
human A3-KAW cell MkL5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{mwcGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> MnvBV2FPT0WU
human PA-1 cell NHfoPWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?= MnTNV2FPT0WU
human ES7 cell NWPLTGE3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGnJOI1KdmirYnn0bY9vKG:oIHj1cYFvKEWVNzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFM2PjZizszN NWXLeYhIW0GQR1XS
human ES8 cell M3;ReWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3HKT2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= M{jLU3NCVkeHUh?=
human SW982 cell M3rDSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2DZdWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2OTJ2IN88US=> NVO1RnBpW0GQR1XS
human VA-ES-BJ cell NI\mZWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MorFTY5pcWKrdHnvckBw\iCqdX3hckBXSS2HUz3CTkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTh2Nkeg{txO MX\TRW5ITVJ?
human 697 cell NV\BU2ZzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV34XYJLUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyPjJ|IN88US=> Mm\vV2FPT0WU
human MOLT-4 cell Mn3HS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1HNR2lvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xOzJ2NDFOwG0> MkLCV2FPT0WU
human D-283MED cell M{X5dWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1PWWmlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|OUS4JO6ddQ>? NXXJXmFzW0GQR1XS
human ALL-PO cell M3jYV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3xSFI1UW6qaXLpeIlwdiCxZjDoeY1idiCDTFytVG8h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB4MEezJO69VQ>? Mmq1V2FPT0WU
human NB14 cell MmnCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH7tPIhKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODhzIN88US=> MVrTRW5ITVJ?
human NTERA-S-cl-D1 cell NWnoWVR5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYPm[YkzUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPzd5NTFOwG0> NWDTTZFOW0GQR1XS
human BFTC-905 cell MkXTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTJTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO NV;oPXlYW0GQR1XS
human H4 cell NGm2d3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWX4bJB4UW6qaXLpeIlwdiCxZjDoeY1idiCKNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVAzODFizszN Moq1V2FPT0WU
human CHP-212 cell MonmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXnweFExUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNlEzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zNECzO{DPxE1? NXTtd|V6W0GQR1XS
human A204 cell MkTBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7EUotSUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTR4NzFOwG0> M3K2UHNCVkeHUh?=
human NB69 cell M1HjV2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5DPjliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG1PFY2KM7:TR?= MlG5V2FPT0WU
human P12-ICHIKAWA cell M3XmPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEjnRoVKdmirYnn0bY9vKG:oIHj1cYFvKFBzMj3JR2hKU0GZQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyPzFizszN NHHPUWZUSU6JRWK=
human L-363 cell M3\RSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUPJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE6PyEQvF2= MoPlV2FPT0WU
human ES5 cell NG\aRZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYrJcohq[mm2aX;uJI9nKGi3bXHuJGVUPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUmzOVQh|ryP MYTTRW5ITVJ?
human CAL-51 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYj4RW5SUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? M4rqbXNCVkeHUh?=
human NBsusSR cell MlHsS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGrub5pKdmirYnn0bY9vKG:oIHj1cYFvKE6Ec4XzV3Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ2NUe4JO69VQ>? MYPTRW5ITVJ?
human HOP-92 cell MojES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NE\mbWpKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD25NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd{OUOg{txO M3LEW3NCVkeHUh?=
human DU-4475 cell MmXhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI\FfmlKdmirYnn0bY9vKG:oIHj1cYFvKESXLUS0O|Uh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkS1JO69VQ>? MUjTRW5ITVJ?
human LB1047-RCC cell NUS0TWRXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fsZmlvcGmkaYTpc44hd2ZiaIXtZY4hVEJzMES3MXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMkmyPFEh|ryP NGPWeoVUSU6JRWK=
human D-566MG cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTZ4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxPDR6IN88US=> Ml7kV2FPT0WU
human A375 cell NHf4OJNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjZTY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zNFg2QCEQvF2= MVPTRW5ITVJ?
human ATN-1 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2Pn[mlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4OTh3IN88US=> MWPTRW5ITVJ?
human M059J cell M4PGZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlXKTY5pcWKrdHnvckBw\iCqdX3hckBOODV7SjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|c3PTJizszN NWXpb3ZNW0GQR1XS
human HSC-3 cell M1[2[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYjoNVRDUW6qaXLpeIlwdiCxZjDoeY1idiCKU1OtN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDR{MEig{txO MXHTRW5ITVJ?
human DOHH-2 cell NFOwOGFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1\wc2lvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PThzNDFOwG0> M33WSXNCVkeHUh?=
human G-402 cell Mk\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmPJTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFY2OjVizszN MWPTRW5ITVJ?
human LC-2-ad cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{LNe2lvcGmkaYTpc44hd2ZiaIXtZY4hVENvMj3h[EBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDdzM{Kg{txO NVjSNGZVW0GQR1XS
human LOXIMVI cell NV;SWmQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4r0UGlvcGmkaYTpc44hd2ZiaIXtZY4hVE:[SV3WTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTB3NUKg{txO MWDTRW5ITVJ?
human DK-MG cell MnrSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnXhTY5pcWKrdHnvckBw\iCqdX3hckBFUy2PRzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVczQThizszN MUPTRW5ITVJ?
human HOS cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1m5WGlvcGmkaYTpc44hd2ZiaIXtZY4hUE:VIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT61O|MxQSEQvF2= NV\oPYZUW0GQR1XS
human BHT-101 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkO2TY5pcWKrdHnvckBw\iCqdX3hckBDUFRvMUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42Pzh5NzFOwG0> M3v0eHNCVkeHUh?=
human U-2-OS cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFvXeoZKdmirYnn0bY9vKG:oIHj1cYFvKFVvMj3PV{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTh6ME[g{txO NGi2emRUSU6JRWK=
human D-423MG cell NYPhV4ZsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fI[mlvcGmkaYTpc44hd2ZiaIXtZY4hTC12MkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjB6ME[g{txO M1\TenNCVkeHUh?=
human AN3-CA cell MnrkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2jXc2lvcGmkaYTpc44hd2ZiaIXtZY4hSU5|LVPBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43Ozl7MTFOwG0> MXPTRW5ITVJ?
human TE-11 cell NYm2O202T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OVI5KM7:TR?= MnHCV2FPT0WU
human SK-NEP-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVzpdWE5UW6qaXLpeIlwdiCxZjDoeY1idiCVSz3OSXAuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNkWzO|Yh|ryP M3[wc3NCVkeHUh?=
human MG-63 cell M4fzcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHS5OW9KdmirYnn0bY9vKG:oIHj1cYFvKE2JLU[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43QDV4NzFOwG0> MlH2V2FPT0WU
human RH-1 cell MYrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDuTY5pcWKrdHnvckBw\iCqdX3hckBTUC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NFI4PCEQvF2= MofCV2FPT0WU
human MDA-MB-157 cell NInWRlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4DpfmlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVE2PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{G2O|Qh|ryP MnnjV2FPT0WU
human A427 cell M3zCe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOVg6KM7:TR?= MlHUV2FPT0WU
human ES1 cell MnfuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGVUOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{W0OVEh|ryP NVLyWlBXW0GQR1XS
human C32 cell NUTtelZ3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1T0cGlvcGmkaYTpc44hd2ZiaIXtZY4hSzN{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OlM6KM7:TR?= MWnTRW5ITVJ?
human LAMA-84 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NET0OXJKdmirYnn0bY9vKG:oIHj1cYFvKEyDTVGtPFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd4OEeyJO69VQ>? M3HmZXNCVkeHUh?=
human YKG-1 cell MlvoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTRVo1KdmirYnn0bY9vKG:oIHj1cYFvKFmNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44PzF{NDFOwG0> M2PvXHNCVkeHUh?=
human NCI-H1048 cell MnnoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzh3MEmg{txO NX6zV5RpW0GQR1XS
human KS-1 cell NUjNXHFIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVjxZlVSUW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45Ojl6IN88US=> M3TuV3NCVkeHUh?=
human JVM-3 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIjsSmJKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjR7MTFOwG0> M3jwZXNCVkeHUh?=
human GI-ME-N cell NGiwSlRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlvETY5pcWKrdHnvckBw\iCqdX3hckBIUS2PRT3OJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45PjV|IN88US=> M4HCTHNCVkeHUh?=
human GT3TKB cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XxW2lvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QTZ2MjFOwG0> M2P1OnNCVkeHUh?=
human CHL-1 cell NVHBNolzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUex[3Q1UW6qaXLpeIlwdiCxZjDoeY1idiCFSFytNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTJ|N{mg{txO NWHnU|htW0GQR1XS
human CHP-134 cell M2\CRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVj1UWt{UW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNVM1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NES2O{DPxE1? M13ZfXNCVkeHUh?=
human 8-MG-BA cell NGTRN5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mn7lTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PTd2NDFOwG0> NYniNnJjW0GQR1XS
human HO-1-N-1 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoLlTY5pcWKrdHnvckBw\iCqdX3hckBJVy1zLV6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvQTdzMUeg{txO MkD3V2FPT0WU
human SW1088 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3m3ZmlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzMEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46QTZ5MzFOwG0> MX3TRW5ITVJ?
human SW48 cell NVnmb25XT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXzJcohq[mm2aX;uJI9nKGi3bXHuJHNYPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkCyNFY4KM7:TR?= NUHIdGFtW0GQR1XS
human VM-CUB-1 cell NWPC[2ZPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHZONUOXQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPDFzOTFOwG0> NVXZNlJiW0GQR1XS
human COLO-800 cell NIDINnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIG3fJBKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? MkXTV2FPT0WU
human TI-73 cell M2XT[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXHJcohq[mm2aX;uJI9nKGi3bXHuJHRKNTd|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6xNVM6QSEQvF2= NIXL[5JUSU6JRWK=
human HN cell MmrpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml;hTY5pcWKrdHnvckBw\iCqdX3hckBJViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUKxPVgh|ryP MnGzV2FPT0WU
human DB cell NX7OWVduT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWPn[pZRUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVI3OzFizszN MY\TRW5ITVJ?
human Ca9-22 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4njSGlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> MojyV2FPT0WU
human A549 cell MmnqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF2xPGNKdmirYnn0bY9vKG:oIHj1cYFvKEF3NEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlE{QDB6IN88US=> NUXzeZpyW0GQR1XS
human KGN cell M2K3TWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnXoTY5pcWKrdHnvckBw\iCqdX3hckBMT05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkKyOVk2KM7:TR?= NXLG[Gt7W0GQR1XS
human BCPAP cell NWXxUYVZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmHLTY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN NIDESYdUSU6JRWK=
human Ramos-2G6-4C10 cell NIT3T3dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWjJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yN|c2QSEQvF2= NY\GNJlDW0GQR1XS
human OVCAR-5 cell MlPQS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUnt[FZlUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{N{ezOEDPxE1? MVfTRW5ITVJ?
human KG-1 cell NV\aTJBYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKGi3bXHuJGtINTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkK3O|kzKM7:TR?= NUjXW4pTW0GQR1XS
human CAKI-1 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoDETY5pcWKrdHnvckBw\iCqdX3hckBESUuLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI5ODV6IN88US=> NYjIRoRwW0GQR1XS
human QIMR-WIL cell MoTFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFjoWoRKdmirYnn0bY9vKG:oIHj1cYFvKFGLTWKtW2lNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OEe0OEDPxE1? NUfEXllNW0GQR1XS
human SW1710 cell NVnOPIdGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3fnbWlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTF2MjFOwG0> M{TzS3NCVkeHUh?=
human SK-UT-1 cell NX3ueZpUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3LkWmlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjl|M{mg{txO MoftV2FPT0WU
human IST-SL1 cell NH7Db2NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXjJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> MYDTRW5ITVJ?
human SW962 cell M{jZeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX;YSGhTUW6qaXLpeIlwdiCxZjDoeY1idiCVV{m2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzN5NUeg{txO NWPLN5RLW0GQR1XS
human EM-2 cell NUe5d4hDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHzUZY9KdmirYnn0bY9vKG:oIHj1cYFvKEWPLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM2OzN5IN88US=> M1m2[3NCVkeHUh?=
human D-263MG cell NYfXO4xPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1:xU2lvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzh|Mkeg{txO MYPTRW5ITVJ?
human T98G cell NV\tZ3dRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoTMTY5pcWKrdHnvckBw\iCqdX3hckBVQTiJIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPFg2PyEQvF2= Moi2V2FPT0WU
human CTB-1 cell M1PNS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mo\ITY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN MYrTRW5ITVJ?
human Hs-578-T cell M2jodGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1vLWWlvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? NVzISVMxW0GQR1XS
human SF126 cell MUjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWfERlVsUW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPDN4MkGg{txO NFz1OXFUSU6JRWK=
human NCI-H460 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> MlPIV2FPT0WU
human NCI-H1755 cell MlvHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF;wdJZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVc2PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUSwOFMh|ryP NX7pUlY1W0GQR1XS
human HL-60 cell NH32cWNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLHXIpKdmirYnn0bY9vKG:oIHj1cYFvKEiOLU[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42PDF3OTFOwG0> NXjJV2wyW0GQR1XS
human G-401 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmHPTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYxQTlizszN M3zwbnNCVkeHUh?=
human AGS cell MoXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJGFIWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNU[yOVch|ryP MnuyV2FPT0WU
human HuO9 cell MnvpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV3Jcohq[mm2aX;uJI9nKGi3bXHuJGh2VzliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2OFU3KM7:TR?= Mn;LV2FPT0WU
human MFE-280 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG1HTS1{OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3Pjh4IN88US=> MnTUV2FPT0WU
human NCI-H292 cell NWPhc3pST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnvkTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEK5NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTd5MkKg{txO MWjTRW5ITVJ?
human HuO-3N1 cell NEPJfIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF22bmJKdmirYnn0bY9vKG:oIHj1cYFvKEi3Tz2zUlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjZyM{C3JO69VQ>? NXjWWHBJW0GQR1XS
human ES3 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVTJcohq[mm2aX;uJI9nKGi3bXHuJGVUOyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkKyPFUh|ryP M3\ocXNCVkeHUh?=
human LB2241-RCC cell Mm\WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4P2R2lvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNkmwO|kh|ryP MW\TRW5ITVJ?
human NCI-H1155 cell NW\wdGZwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWTIdXduUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5OFA2KM7:TR?= M4XqbHNCVkeHUh?=
human SW872 cell MnnES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXvJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj63NFY4PiEQvF2= Mn;GV2FPT0WU
human MHH-ES-1 cell NHewOHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYfzNm0xUW6qaXLpeIlwdiCxZjDoeY1idiCPSFitSXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K2N|Mh|ryP MkPZV2FPT0WU
human KYSE-150 cell M{nHVGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUTwZ3lwUW6qaXLpeIlwdiCxZjDoeY1idiCNWWPFMVE2OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K5O{DPxE1? Mn\4V2FPT0WU
human MC-IXC cell NEm1PIdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3PKfWlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTV|IN88US=> M2nDOnNCVkeHUh?=
human HCC1187 cell M1XE[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M33CNGlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO NVTBU5VVW0GQR1XS
human UMC-11 cell NFnLS|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJHVOSy1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVA1PzdizszN M2nXUHNCVkeHUh?=
human NB5 cell M13ZcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWXDUGl7UW6qaXLpeIlwdiCxZjDoeY1idiCQQkWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlk{PzF3IN88US=> NILYN5NUSU6JRWK=
human A2058 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmHrTY5pcWKrdHnvckBw\iCqdX3hckBCOjB3ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVc5PDRizszN MmHuV2FPT0WU
human Becker cell MlPxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIHKU4xKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO MofvV2FPT0WU
human CAS-1 cell MnLtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGL3U4RKdmirYnn0bY9vKG:oIHj1cYFvKEODUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTV4OTFOwG0> NYDVZ3ByW0GQR1XS
human SW780 cell M33r[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXXJcohq[mm2aX;uJI9nKGi3bXHuJHNYPzhyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6yOVYxQSEQvF2= NHjaWFBUSU6JRWK=
human KM12 cell NHz2ZlVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVXJeWVGUW6qaXLpeIlwdiCxZjDoeY1idiCNTUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4{ODF|MjFOwG0> NYjqVpE5W0GQR1XS
human PC-3 cell MoLxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXXJcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkG3OFEyKM7:TR?= NWfvbWdvW0GQR1XS
human A253 cell NGnJXZBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIPyXGVKdmirYnn0bY9vKG:oIHj1cYFvKEF{NUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE5QDl|IN88US=> NYrJPZJ[W0GQR1XS
human NB10 cell M2LUdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIPjVVhKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPzd|IN88US=> M1TxV3NCVkeHUh?=
human A172 cell Ml;PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoqzTY5pcWKrdHnvckBw\iCqdX3hckBCOTd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60OFU4KM7:TR?= NV3TPGdIW0GQR1XS
human A498 cell M2rRSGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfUTY5pcWKrdHnvckBw\iCqdX3hckBCPDl6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND61OlM5OyEQvF2= NGSxU5VUSU6JRWK=
human SW1573 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGq1N|BKdmirYnn0bY9vKG:oIHj1cYFvKFOZMUW3N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVYvQTB2OUGg{txO NWTzOYljW0GQR1XS
human 5637 cell M1vZe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3jvNGlvcGmkaYTpc44hd2ZiaIXtZY4hPTZ|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNFc6ODRizszN M4nrdHNCVkeHUh?=
human A388 cell NXvte3dRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYLJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= NUT3WGg1W0GQR1XS
human U251 cell M1mxXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MofWTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= MXvTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
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  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A
Smiles IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID