BX-795

For research use only.

Catalog No.S1274

39 publications

BX-795 Chemical Structure

CAS No. 702675-74-9

BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1.

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Selleck's BX-795 has been cited by 39 publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NET4ZnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnLMTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= NVr6dYh3W0GQR1XS
KRX cells NIHRblFHfW6ldHnvckBie3OjeR?= M{\aN|chdWmwcx?= NUHYUoo3UW6qaXLpeIlwdiCxZjDTWW1QNXSjZ3fl[EBWVEtzIDj1cotvd3ewIH;ybYdqdilia3nuZZNmKGSxbXHpckBmgHC{ZYPz[YQhcW5iS2LYJINmdGy|IIXzbY5oKFt|MmDdMYdidW2jLVHUVEBidmRibYnlcIlvKGKjc3njJJBzd3SnaX6gd5Vje3S{YYTlJIlv[3WkYYTl[EBnd3JiNzDtbY5{ NFzpZnozPjJ5NU[4NS=>
human NKM-1 cell M2PEU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnHnTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|YyQTRizszN MVHTRW5ITVJ?
human P30-OHK cell NUTQTGVPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{[4Z2lvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? Mnj5V2FPT0WU
human YH-13 cell NGTqcY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXvJcohq[mm2aX;uJI9nKGi3bXHuJHlJNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62Nlg5QCEQvF2= NF7DUHZUSU6JRWK=
human LXF-289 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnLTTY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NE43PTZ7MzFOwG0> MVnTRW5ITVJ?
human BE-13 cell NFv3bnFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlLBTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|A1PzdizszN NFnKeFFUSU6JRWK=
human RS4-11 cell M{PJbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHJUPC1zMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuO|I2QTRizszN MWnTRW5ITVJ?
human A3-KAW cell NXfqSFBXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1[xOWlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> MorOV2FPT0WU
human PA-1 cell MnTzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWnJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?= NVnJUZB{W0GQR1XS
human ES7 cell NHrvW2lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnnQTY5pcWKrdHnvckBw\iCqdX3hckBGWzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkizOVY3KM7:TR?= MUfTRW5ITVJ?
human ES8 cell M1fsO2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGVUQCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOESzN|Yh|ryP MoXDV2FPT0WU
human SW982 cell NYG5elZtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnGzTY5pcWKrdHnvckBw\iCqdX3hckBUXzl6MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPVUyOjRizszN NX7jdVhDW0GQR1XS
human VA-ES-BJ cell M4LET2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFy5eGhKdmirYnn0bY9vKG:oIHj1cYFvKF[DLVXTMWJLKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC57OES2O{DPxE1? M4DROnNCVkeHUh?=
human 697 cell MmjzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1LKe2lvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVYzOyEQvF2= M{GyZXNCVkeHUh?=
human MOLT-4 cell NFqxfHRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFMzPDRizszN MX;TRW5ITVJ?
human D-283MED cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHu5eWNKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yM{m0PEDPpG1? NVqxNo1lW0GQR1XS
human ALL-PO cell MojWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2Oz[WlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4xPjB5MzFOwG0> NWLHWHFNW0GQR1XS
human NB14 cell M4LKWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoC5TY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= NHvLTFhUSU6JRWK=
human NTERA-S-cl-D1 cell MnzUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoLOTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wO|c4PSEQvF2= M4K0NXNCVkeHUh?=
human BFTC-905 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXi2NXRsUW6qaXLpeIlwdiCxZjDoeY1idiCERmTDMVkxPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEixNFEh|ryP NXTuO4JwW0GQR1XS
human H4 cell M1jjbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3LyTWlvcGmkaYTpc44hd2ZiaIXtZY4hUDRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkGwNlAyKM7:TR?= MVTTRW5ITVJ?
human CHP-212 cell NXzjV5RHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUfJcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1ODN5IN88US=> NHr0TVdUSU6JRWK=
human A204 cell NWe1WZBTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4TFS2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU1PjdizszN NXzMVGM{W0GQR1XS
human NB69 cell NUHHTYpMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn7aTY5pcWKrdHnvckBw\iCqdX3hckBPSjZ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVg3PSEQvF2= NX;0TWNNW0GQR1XS
human P12-ICHIKAWA cell M3zZb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHz4R3ZKdmirYnn0bY9vKG:oIHj1cYFvKFBzMj3JR2hKU0GZQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyPzFizszN M4L6V3NCVkeHUh?=
human L-363 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGO4[GdKdmirYnn0bY9vKG:oIHj1cYFvKExvM{[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yQDF7NzFOwG0> NVPHVm9TW0GQR1XS
human ES5 cell NX7uO25WT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKGi3bXHuJGVUPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUmzOVQh|ryP NHPGfY9USU6JRWK=
human CAL-51 cell NIfrZndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXnXS3I6UW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? M1roU3NCVkeHUh?=
human NBsusSR cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWjJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI1PTd6IN88US=> M2DrRXNCVkeHUh?=
human HOP-92 cell M3i2Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHaXotKdmirYnn0bY9vKG:oIHj1cYFvKEiRUD25NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOjd{OUOg{txO NVz5c2R7W0GQR1XS
human DU-4475 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF7BUWNKdmirYnn0bY9vKG:oIHj1cYFvKESXLUS0O|Uh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkS1JO69VQ>? NICwTGNUSU6JRWK=
human LB1047-RCC cell Mn\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJGxDOTB2Nz3SR2Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkixJO69VQ>? MYHTRW5ITVJ?
human D-566MG cell NWe0OZRFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGfGRmdKdmirYnn0bY9vKG:oIHj1cYFvKERvNU[2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjNyNES4JO69VQ>? NXjXUpF6W0GQR1XS
human A375 cell Mn3qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHzhc4NKdmirYnn0bY9vKG:oIHj1cYFvKEF|N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxQDV6IN88US=> Moq4V2FPT0WU
human ATN-1 cell MlfyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYHlTHdUUW6qaXLpeIlwdiCxZjDoeY1idiCDVF6tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzdzOEWg{txO NGrnelNUSU6JRWK=
human M059J cell M3zVNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Ml34TY5pcWKrdHnvckBw\iCqdX3hckBOODV7SjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|c3PTJizszN MlPuV2FPT0WU
human HSC-3 cell NUDWZVZ7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGhUSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OFIxQCEQvF2= NXXDe3ZxW0GQR1XS
human DOHH-2 cell NEj6e4hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHX0W21KdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDV6MUSg{txO MVLTRW5ITVJ?
human G-402 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mke1TY5pcWKrdHnvckBw\iCqdX3hckBINTRyMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFY2OjVizszN NWGxcpBlW0GQR1XS
human LC-2-ad cell Mo\yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HVUGlvcGmkaYTpc44hd2ZiaIXtZY4hVENvMj3h[EBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDdzM{Kg{txO NWTDfJNMW0GQR1XS
human LOXIMVI cell M3XOb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFrWNlBKdmirYnn0bY9vKG:oIHj1cYFvKEyRWFnNWmkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjVyNUWyJO69VQ>? NVHYW5doW0GQR1XS
human DK-MG cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4iwTmlvcGmkaYTpc44hd2ZiaIXtZY4hTEtvTVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU4Ojl6IN88US=> M1PUZnNCVkeHUh?=
human HOS cell M1LNUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWLJcohq[mm2aX;uJI9nKGi3bXHuJGhQWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNUezNFkh|ryP M1fXWnNCVkeHUh?=
human BHT-101 cell NUHNOVN2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX3OVJo3UW6qaXLpeIlwdiCxZjDoeY1idiCESGStNVAyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS53N{i3O{DPxE1? M1TVcHNCVkeHUh?=
human U-2-OS cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJHUuOi2RUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVg5ODZizszN NVvqTIhyW0GQR1XS
human D-423MG cell MmLXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHHnO|dKdmirYnn0bY9vKG:oIHj1cYFvKERvNEKzUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZyOEC2JO69VQ>? NF7WWJpUSU6JRWK=
human AN3-CA cell MoTFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGFPOy2FQTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlM6QTFizszN MUPTRW5ITVJ?
human TE-11 cell NH;vPHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFnnTFJKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU43PTJ6IN88US=> NUTDWXFiW0GQR1XS
human SK-NEP-1 cell NYHiRVJET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFj4Om1KdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS54NUO3OkDPxE1? NXG1S4c5W0GQR1XS
human MG-63 cell MonqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnjDTY5pcWKrdHnvckBw\iCqdX3hckBOTy14MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlg2PjdizszN MWPTRW5ITVJ?
human RH-1 cell M1Gzemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{e4[GlvcGmkaYTpc44hd2ZiaIXtZY4hWkhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|AzPzRizszN MoC2V2FPT0WU
human MDA-MB-157 cell NY\HfGNpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\KcJF6UW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTV5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVY4PCEQvF2= NYXmc5N5W0GQR1XS
human A427 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHYNFlKdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc{PTh7IN88US=> NFviXW9USU6JRWK=
human ES1 cell MkXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnH4TY5pcWKrdHnvckBw\iCqdX3hckBGWzFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke1OFUyKM7:TR?= MVfTRW5ITVJ?
human C32 cell Mk\aS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnHSTY5pcWKrdHnvckBw\iCqdX3hckBEOzJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLke2N|kh|ryP NEC3UphUSU6JRWK=
human LAMA-84 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4nkbGlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzZ6N{Kg{txO NYTBdJAxW0GQR1XS
human YKG-1 cell NIrGNmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2T2S2lvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTJ2IN88US=> NHLVRphUSU6JRWK=
human NCI-H1048 cell Mk[wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHHV[GhKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVA1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{i1NFkh|ryP NUK0e3RMW0GQR1XS
human KS-1 cell NInSbo9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV\GSlR6UW6qaXLpeIlwdiCxZjDoeY1idiCNUz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45Ojl6IN88US=> MX;TRW5ITVJ?
human JVM-3 cell M4LVR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MX;Jcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64OlQ6OSEQvF2= NFfZPVhUSU6JRWK=
human GI-ME-N cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFzKXJdKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO NXHHeoR4W0GQR1XS
human GT3TKB cell Ml7PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmXyTY5pcWKrdHnvckBw\iCqdX3hckBIXDOWS1KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg6PjR{IN88US=> MmX5V2FPT0WU
human CHL-1 cell Mn;HS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFvZZoZKdmirYnn0bY9vKG:oIHj1cYFvKEOKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46OjN5OTFOwG0> MmL2V2FPT0WU
human CHP-134 cell NVLXSHFsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NEPLUlhKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2xN|Qh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl2NE[3JO69VQ>? NEXYWINUSU6JRWK=
human 8-MG-BA cell NXzjUplVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkLLTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PTd2NDFOwG0> MoHYV2FPT0WU
human HO-1-N-1 cell NIixToNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFe2OGdKdmirYnn0bY9vKG:oIHj1cYFvKEiRLUGtUk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{GxO{DPxE1? M1qzW3NCVkeHUh?=
human SW1088 cell M4Tze2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUT0dnA4UW6qaXLpeIlwdiCxZjDoeY1idiCVV{GwPFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7NkezJO69VQ>? MlnqV2FPT0WU
human SW48 cell NVzlbplST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYrJcohq[mm2aX;uJI9nKGi3bXHuJHNYPDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkCyNFY4KM7:TR?= NX;jSWJUW0GQR1XS
human VM-CUB-1 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJHZONUOXQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPDFzOTFOwG0> M{fsNnNCVkeHUh?=
human COLO-800 cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1\rS2lvcGmkaYTpc44hd2ZiaIXtZY4hS0:OTz24NFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjB3MUO2JO69VQ>? MWfTRW5ITVJ?
human TI-73 cell NIT2e4dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4\PR2lvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEyOzl7IN88US=> M{m1NHNCVkeHUh?=
human HN cell MmXkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJGhPKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMkG5PEDPxE1? M2TqR3NCVkeHUh?=
human DB cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkXOTY5pcWKrdHnvckBw\iCqdX3hckBFSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMUK2N|Eh|ryP MYPTRW5ITVJ?
human Ca9-22 cell MlHmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2HzTWlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> Ml;5V2FPT0WU
human A549 cell NFjSWpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEX2WnlKdmirYnn0bY9vKG:oIHj1cYFvKEF3NEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlE{QDB6IN88US=> Mke5V2FPT0WU
human KGN cell M1XvVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHfwU5pKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN M1XGbnNCVkeHUh?=
human BCPAP cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlvZTY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN MVXTRW5ITVJ?
human Ramos-2G6-4C10 cell NGTrOFVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUnuNmxuUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjN5NUmg{txO NEjZdZlUSU6JRWK=
human OVCAR-5 cell M1XtW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnLzTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd|NDFOwG0> NWfkWlk2W0GQR1XS
human KG-1 cell NEPnVXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlG2TY5pcWKrdHnvckBw\iCqdX3hckBMTy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yO|c6OiEQvF2= MlfLV2FPT0WU
human CAKI-1 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUHJcohq[mm2aX;uJI9nKGi3bXHuJGNCU0lvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlgxPThizszN NVLhV|dwW0GQR1XS
human QIMR-WIL cell NG\FPY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPXN2dFUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP MXTTRW5ITVJ?
human SW1710 cell M2fOWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3LFZWlvcGmkaYTpc44hd2ZiaIXtZY4hW1dzN{GwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zQTF2MjFOwG0> MlX1V2FPT0WU
human SK-UT-1 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NX3r[ndnUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OUOzPUDPxE1? NVLnfHFsW0GQR1XS
human IST-SL1 cell Mo\1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlH6TY5pcWKrdHnvckBw\iCqdX3hckBKW1RvU1yxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{OjF5NDFOwG0> M3jXSXNCVkeHUh?=
human SW962 cell NHmzWGlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHjrc5VKdmirYnn0bY9vKG:oIHj1cYFvKFOZOU[yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{Ozd3NzFOwG0> MmfnV2FPT0WU
human EM-2 cell M4XQXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXO0NpZsUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{PTN|NzFOwG0> NGPEb5NUSU6JRWK=
human D-263MG cell M1npUmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2X4ZWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{NkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOzh|Mkeg{txO MVzTRW5ITVJ?
human T98G cell MlX4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmK0TY5pcWKrdHnvckBw\iCqdX3hckBVQTiJIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPFg2PyEQvF2= MYfTRW5ITVJ?
human CTB-1 cell MkfzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mo\tTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN M1HJW3NCVkeHUh?=
human Hs-578-T cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1vPbGlvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? M{D6WnNCVkeHUh?=
human SF126 cell NXuwRpZtT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zWRWlvcGmkaYTpc44hd2ZiaIXtZY4hW0ZzMk[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlQ{PjJzIN88US=> NWLwPXROW0GQR1XS
human NCI-H460 cell NYTOOmM2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVrJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> MoPmV2FPT0WU
human NCI-H1755 cell NGDvVI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkHMTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEG3OVUh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV2MESzJO69VQ>? NXmwOo1IW0GQR1XS
human HL-60 cell M4jnPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3jTU2lvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU1OTV7IN88US=> NV\WenFTW0GQR1XS
human G-401 cell M2rPOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkTUTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYxQTlizszN M121enNCVkeHUh?=
human AGS cell NYPKNGFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mof2TY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2NlU4KM7:TR?= NF;lUmZUSU6JRWK=
human HuO9 cell NYHORZZHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkSxTY5pcWKrdHnvckBw\iCqdX3hckBJfU97IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlQ2PiEQvF2= MWTTRW5ITVJ?
human MFE-280 cell NIDwe5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1vyR2lvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO NELoZ|dUSU6JRWK=
human NCI-H292 cell MnjMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDUOllKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INlkzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi53N{eyNkDPxE1? MkK3V2FPT0WU
human HuO-3N1 cell NXvDTJRET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlPFTY5pcWKrdHnvckBw\iCqdX3hckBJfU9vM16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43ODNyNzFOwG0> MYfTRW5ITVJ?
human ES3 cell M{m5TGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Moe2TY5pcWKrdHnvckBw\iCqdX3hckBGWzNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[yNlg2KM7:TR?= NG\SR5dUSU6JRWK=
human LB2241-RCC cell M2PEWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnu0TY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUC3PUDPxE1? MXPTRW5ITVJ?
human NCI-H1155 cell Mn\hS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXnQNXI2UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5OFA2KM7:TR?= NV\oOGhQW0GQR1XS
human SW872 cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXX1TlVmUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO NWDKb2dxW0GQR1XS
human MHH-ES-1 cell MonIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWjqWGM6UW6qaXLpeIlwdiCxZjDoeY1idiCPSFitSXMuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwN{K2N|Mh|ryP NF;VcnBUSU6JRWK=
human KYSE-150 cell M4jVbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnvGTY5pcWKrdHnvckBw\iCqdX3hckBMYVOHLUG1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ7NzFOwG0> M4nOeXNCVkeHUh?=
human MC-IXC cell M2PFemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXXleldSUW6qaXLpeIlwdiCxZjDoeY1idiCPQz3JXGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7NUOg{txO NFjKRZJUSU6JRWK=
human HCC1187 cell NX\U[Y1bT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHQdmtpUW6qaXLpeIlwdiCxZjDoeY1idiCKQ1OxNVg4KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi56OU[3O{DPxE1? M{e4R3NCVkeHUh?=
human UMC-11 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mnn4TY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> NG\NeJhUSU6JRWK=
human NB5 cell NIXXUmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXLJcohq[mm2aX;uJI9nKGi3bXHuJG5DPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUO3NVUh|ryP NWLkUnpNW0GQR1XS
human A2058 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIjsR4hKdmirYnn0bY9vKG:oIHj1cYFvKEF{MEW4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46Pzh2NDFOwG0> NVnnfm81W0GQR1XS
human Becker cell NYD5Tlh{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoiyTY5pcWKrdHnvckBw\iCqdX3hckBD\WOtZYKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyOTF{IN88US=> MVnTRW5ITVJ?
human CAS-1 cell NV75e|ZDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1ixbGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyPTZ7IN88US=> MVLTRW5ITVJ?
human SW780 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnSyTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlU3ODlizszN NUfze3l5W0GQR1XS
human KM12 cell MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGtOOTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkOwNVMzKM7:TR?= MWDTRW5ITVJ?
human PC-3 cell M{L6eGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NET6fYFKdmirYnn0bY9vKG:oIHj1cYFvKFCFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlE4PDFzIN88US=> MXvTRW5ITVJ?
human A253 cell NWfvOXJLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVLkb|k2UW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> NF;ZWGlUSU6JRWK=
human NB10 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJG5DOTBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkKyO|c{KM7:TR?= M{nFc3NCVkeHUh?=
human A172 cell MmrTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFnhWolKdmirYnn0bY9vKG:oIHj1cYFvKEFzN{KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlQ1PTdizszN NGfLZ|VUSU6JRWK=
human A498 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIHPOphKdmirYnn0bY9vKG:oIHj1cYFvKEF2OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlU3Ozh|IN88US=> MlmxV2FPT0WU
human SW1573 cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXfrNoNtUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G1O|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjlyNEmxJO69VQ>? Ml\wV2FPT0WU
human 5637 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MW\Jcohq[mm2aX;uJI9nKGi3bXHuJFU3OzdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16LkC3PVA1KM7:TR?= MoPQV2FPT0WU
human A388 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUfJcohq[mm2aX;uJI9nKGi3bXHuJGE{QDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MT6xN|k5KM7:TR?= NHLVR4JUSU6JRWK=
human U251 cell MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mk\PTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= NFH3bFJUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
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  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A
Smiles C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID