BX-795

Catalog No.S1274

BX-795 Chemical Structure

Molecular Weight(MW): 591.47

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

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Cited by 20 Publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell NXmzPXNVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV6y[4VoUW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzZwODDuUS=> NIjXNFZUSU6JRWK=
KRX cells MkDCSpVv[3Srb36gZZN{[Xl? NX36enlpPyCvaX7z MoPwTY5pcWKrdHnvckBw\iCVVV3PMZRi\2enZDDVUGsyKCi3bnvuc5dvKG:{aXfpckkhc2mwYYPlJIRwdWGrbjDlfJBz\XO|ZXSgbY4hU1K[IHPlcIx{KHW|aX7nJHs{OlCfLXfhcY1iNUGWUDDhcoQhdXmnbHnuJIJie2mlIIDyc5RmcW5ic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhPyCvaX7z NIjT[JEzPjJ5NU[4NS=>
human NKM-1 cell NYTrNIV{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXfBNWV5UW6qaXLpeIlwdiCxZjDoeY1idiCQS12tNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOzZzOUSg{txO MX\TRW5ITVJ?
human P30-OHK cell NFnBZ4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGnkSINKdmirYnn0bY9vKG:oIHj1cYFvKFB|MD3PTGsh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTygTWM2OD1yLkS5OlUh|ryP NVf1SmFEW0GQR1XS
human YH-13 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX;Jcohq[mm2aX;uJI9nKGi3bXHuJHlJNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62Nlg5QCEQvF2= MXLTRW5ITVJ?
human LXF-289 cell M1WxcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYnUdpNLUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XlwIFnDOVA:OC54NU[5N{DPxE1? NUXmPIxyW0GQR1XS
human BE-13 cell Mo\5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3zEbGlvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlcxPDd5IN88US=> NXfQenpUW0GQR1XS
human RS4-11 cell NW\aXVV[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYTveYhwUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{NUm0JO69VQ>? M2rwW3NCVkeHUh?=
human A3-KAW cell MkWyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M12weGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44OzB3NTFOwG0> NGrsTmJUSU6JRWK=
human PA-1 cell NFPjOVJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYn0VpY2UW6qaXLpeIlwdiCxZjDoeY1idiCSQT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45ODR{MjFOwG0> NVXyTVQ4W0GQR1XS
human ES7 cell M1;xT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1XtSGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64N|U3PiEQvF2= MXLTRW5ITVJ?
human ES8 cell NV3vN|I2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M37ITGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD64OFM{PiEQvF2= MXrTRW5ITVJ?
human SW982 cell NYrjXWhwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fqNGlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlk2OTJ2IN88US=> NE\3V|FUSU6JRWK=
human VA-ES-BJ cell NWDIenRkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXLvOopyUW6qaXLpeIlwdiCxZjDoeY1idiCYQT3FV{1DUiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOUi0Olch|ryP M2LU[nNCVkeHUh?=
human 697 cell NGfSS5dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\SbY02UW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlAyPjJ|IN88US=> NFnqTHhUSU6JRWK=
human MOLT-4 cell NV3hZ3gyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXfJcohq[mm2aX;uJI9nKGi3bXHuJG1QVFRvNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFMzPDRizszN M1HheXNCVkeHUh?=
human D-283MED cell M{jDR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYPOe4dnUW6qaXLpeIlwdiCxZjDoeY1idiCGLUK4N21GTCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMEO5OFgh|pyv MV;TRW5ITVJ?
human ALL-PO cell NGm2T3ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlPJTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODd|IN88US=> NHzxXpdUSU6JRWK=
human NB14 cell NUX2T3NVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvoTY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= MoXvV2FPT0WU
human NTERA-S-cl-D1 cell M4qz[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3joWmlvcGmkaYTpc44hd2ZiaIXtZY4hVlSHUlGtV{1kdC2GMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNFc4PzVizszN M2i3THNCVkeHUh?=
human BFTC-905 cell M3q1N2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlfzTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO MnLQV2FPT0WU
human H4 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MojUTY5pcWKrdHnvckBw\iCqdX3hckBJPCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUCyNFEh|ryP NFzWUlRUSU6JRWK=
human CHP-212 cell M2LtUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGNJWC1{MUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE1ODN5IN88US=> MWfTRW5ITVJ?
human A204 cell NV\oOXlLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVTWZW1TUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPTR4NzFOwG0> MXfTRW5ITVJ?
human NB69 cell NWjVcZp5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlHITY5pcWKrdHnvckBw\iCqdX3hckBPSjZ7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xOVg3PSEQvF2= NHPLcGxUSU6JRWK=
human P12-ICHIKAWA cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3Xub2lvcGmkaYTpc44hd2ZiaIXtZY4hWDF{LVnDTGlMSVeDIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE4OSEQvF2= NWT3VJA{W0GQR1XS
human L-363 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlzqTY5pcWKrdHnvckBw\iCqdX3hckBNNTN4MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVgyQTdizszN MUHTRW5ITVJ?
human ES5 cell Ml25S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4\pR2lvcGmkaYTpc44hd2ZiaIXtZY4hTVN3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPVM2PCEQvF2= MojaV2FPT0WU
human CAL-51 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmeyTY5pcWKrdHnvckBw\iCqdX3hckBESUxvNUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlIzOTV4IN88US=> MWTTRW5ITVJ?
human NBsusSR cell NUXLSFJGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWrJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI1PTd6IN88US=> NHPQWlVUSU6JRWK=
human HOP-92 cell NF3wdWtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUXJcohq[mm2aX;uJI9nKGi3bXHuJGhQWC17MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNlczQTNizszN M2PKWHNCVkeHUh?=
human DU-4475 cell MmrvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTR2N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlI6OjR3IN88US=> MYXTRW5ITVJ?
human LB1047-RCC cell M1nub2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEPNW3pKdmirYnn0bY9vKG:oIHj1cYFvKEyEMUC0O{1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkK5NlgyKM7:TR?= MVjTRW5ITVJ?
human D-566MG cell NGPvXZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NU\FNXVjUW6qaXLpeIlwdiCxZjDoeY1idiCGLUW2Om1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5|MES0PEDPxE1? MkXqV2FPT0WU
human A375 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLa[3BKdmirYnn0bY9vKG:oIHj1cYFvKEF|N{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlMxQDV6IN88US=> M3LMXnNCVkeHUh?=
human ATN-1 cell MoP6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn7DTY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|cyQDVizszN NYTHNpM1W0GQR1XS
human M059J cell NI\LSHRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3LTdWlvcGmkaYTpc44hd2ZiaIXtZY4hVTB3OVqgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlM4PjV{IN88US=> NXO2O3JLW0GQR1XS
human HSC-3 cell Ml6zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml3wTY5pcWKrdHnvckBw\iCqdX3hckBJW0NvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFQzODhizszN MUDTRW5ITVJ?
human DOHH-2 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYrJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOFU5OTRizszN MoLlV2FPT0WU
human G-402 cell MkTPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGcuPDB{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OlUzPSEQvF2= NY\UfJlXW0GQR1XS
human LC-2-ad cell NGn2[lBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MonOTY5pcWKrdHnvckBw\iCqdX3hckBNSy1{LXHkJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PzF|MjFOwG0> M3n5TnNCVkeHUh?=
human LOXIMVI cell NWjScVRWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnOyTY5pcWKrdHnvckBw\iCqdX3hckBNV1iLTW\JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42ODV3MjFOwG0> MXnTRW5ITVJ?
human DK-MG cell MnzOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlrNTY5pcWKrdHnvckBw\iCqdX3hckBFUy2PRzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOVczQThizszN MXPTRW5ITVJ?
human HOS cell NFPQUpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUjJcohq[mm2aX;uJI9nKGi3bXHuJGhQWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNUezNFkh|ryP NG\Hdo1USU6JRWK=
human BHT-101 cell NY\OfGhlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3Pk[GlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd6N{eg{txO MUTTRW5ITVJ?
human U-2-OS cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlXPTY5pcWKrdHnvckBw\iCqdX3hckBWNTJvT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlU5QDB4IN88US=> NUK1WnNPW0GQR1XS
human D-423MG cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3jBbmlvcGmkaYTpc44hd2ZiaIXtZY4hTC12MkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjB6ME[g{txO NV;6W4FIW0GQR1XS
human AN3-CA cell M3LwfGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH;PS25KdmirYnn0bY9vKG:oIHj1cYFvKEGQMz3DRUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjN7OUGg{txO MojXV2FPT0WU
human TE-11 cell NEDDS2JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVvYW|d1UW6qaXLpeIlwdiCxZjDoeY1idiCWRT2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjV{ODFOwG0> MmDuV2FPT0WU
human SK-NEP-1 cell M{XYTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3Hv[2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ3M{e2JO69VQ>? MmnTV2FPT0WU
human MG-63 cell NHixZoxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWPJcohq[mm2aX;uJI9nKGi3bXHuJG1INTZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62PFU3PyEQvF2= M{\pVnNCVkeHUh?=
human RH-1 cell M2LESWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4fzSGlvcGmkaYTpc44hd2ZiaIXtZY4hWkhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|AzPzRizszN M1rnUnNCVkeHUh?=
human MDA-MB-157 cell MkLIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2xOVch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjdzNke0JO69VQ>? MkDlV2FPT0WU
human A427 cell NUDaU5hzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVfJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOVg6KM7:TR?= NXjUflAzW0GQR1XS
human ES1 cell Mnm1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrXR4JKdmirYnn0bY9vKG:oIHj1cYFvKEWVMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|U1PTFizszN M{KySHNCVkeHUh?=
human C32 cell NX3HR|FzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIfLeJRKdmirYnn0bY9vKG:oIHj1cYFvKEN|MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuO|Y{QSEQvF2= M37iVnNCVkeHUh?=
human LAMA-84 cell NHPLNVZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVHGbnZOUW6qaXLpeIlwdiCxZjDoeY1idiCOQV3BMVg1KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS55Nki3NkDPxE1? M{PlXnNCVkeHUh?=
human YKG-1 cell NX\oSpJFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF3o[YxKdmirYnn0bY9vKG:oIHj1cYFvKFmNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44PzF{NDFOwG0> M2G2[3NCVkeHUh?=
human NCI-H1048 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml\pTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEGwOFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjd6NUC5JO69VQ>? NYLQZ2ZXW0GQR1XS
human KS-1 cell NEHrbldIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mm\tTY5pcWKrdHnvckBw\iCqdX3hckBMWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT64Nlk5KM7:TR?= MVPTRW5ITVJ?
human JVM-3 cell NVvEelNqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml\PTY5pcWKrdHnvckBw\iCqdX3hckBLXk1vMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFY1QTFizszN NFXj[I5USU6JRWK=
human GI-ME-N cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHzFS5RKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO M3TtR3NCVkeHUh?=
human GT3TKB cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVLQbINYUW6qaXLpeIlwdiCxZjDoeY1idiCJVEPUT2Ih[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh7NkSyJO69VQ>? MYfTRW5ITVJ?
human CHL-1 cell M{[wUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFjBcpdKdmirYnn0bY9vKG:oIHj1cYFvKEOKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46OjN5OTFOwG0> MoLzV2FPT0WU
human CHP-134 cell NFT3cVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFSye3FKdmirYnn0bY9vKG:oIHj1cYFvKEOKUD2xN|Qh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl2NE[3JO69VQ>? MUTTRW5ITVJ?
human 8-MG-BA cell M2TZU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYL5b|BTUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57NUe0OEDPxE1? NF;2To5USU6JRWK=
human HO-1-N-1 cell NVzZZWNpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFnSem1KdmirYnn0bY9vKG:oIHj1cYFvKEiRLUGtUk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{GxO{DPxE1? MXTTRW5ITVJ?
human SW1088 cell NGHTdo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX;WXo9jUW6qaXLpeIlwdiCxZjDoeY1idiCVV{GwPFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7NkezJO69VQ>? M3j5bnNCVkeHUh?=
human SW48 cell NFfFbnZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkX1TY5pcWKrdHnvckBw\iCqdX3hckBUXzR6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wNlA3PyEQvF2= MYnTRW5ITVJ?
human VM-CUB-1 cell M3nqRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoLJTY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO MlHaV2FPT0WU
human COLO-800 cell NVzTfXhjT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGHxTGNKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? NWmye3h7W0GQR1XS
human TI-73 cell MmPUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEC1Z5VKdmirYnn0bY9vKG:oIHj1cYFvKFSLLUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOTN7OTFOwG0> MWrTRW5ITVJ?
human HN cell NYLac5hYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4DCcGlvcGmkaYTpc44hd2ZiaIXtZY4hUE5iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNVk5KM7:TR?= M{XZTnNCVkeHUh?=
human DB cell NVHuT2FVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUDJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5zMk[zNUDPxE1? NVrpcFQxW0GQR1XS
human Ca9-22 cell MlTVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWW1N5hbUW6qaXLpeIlwdiCxZjDoeY1idiCFYUmtNlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjF{OES3JO69VQ>? MljSV2FPT0WU
human A549 cell MmTiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2iyfGlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNVM5ODhizszN MV7TRW5ITVJ?
human KGN cell NU\aV3dzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWjJcohq[mm2aX;uJI9nKGi3bXHuJGtIViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMkK1PVUh|ryP Ml;nV2FPT0WU
human BCPAP cell NWLM[JNYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXewTpcyUW6qaXLpeIlwdiCxZjDoeY1idiCEQ2DBVEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjNzNUig{txO MUHTRW5ITVJ?
human Ramos-2G6-4C10 cell M1XMdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6yN|c2QSEQvF2= NGP0N4pUSU6JRWK=
human OVCAR-5 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1nMb2lvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjd5M{Sg{txO MmPmV2FPT0WU
human KG-1 cell MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH7Jd2xKdmirYnn0bY9vKG:oIHj1cYFvKEuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI4Pzl{IN88US=> MorVV2FPT0WU
human CAKI-1 cell NXKxeVVmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoXnTY5pcWKrdHnvckBw\iCqdX3hckBESUuLLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI5ODV6IN88US=> NWjCT|V7W0GQR1XS
human QIMR-WIL cell MmD3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1L6T2lvcGmkaYTpc44hd2ZiaIXtZY4hWUmPUj3XTWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6N{S0JO69VQ>? M1fCfHNCVkeHUh?=
human SW1710 cell NY\Cc2ZYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUTJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTdzMDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlkyPDJizszN NIfrNVJUSU6JRWK=
human SK-UT-1 cell Mm\nS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIjTe4hKdmirYnn0bY9vKG:oIHj1cYFvKFONLWXUMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ7M{O5JO69VQ>? MlfIV2FPT0WU
human IST-SL1 cell NWnLSY84T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> M1;sUXNCVkeHUh?=
human SW962 cell NFHZVYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVnJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zN|c2PyEQvF2= M4HrdnNCVkeHUh?=
human EM-2 cell NHXpSJZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXzGN4ZxUW6qaXLpeIlwdiCxZjDoeY1idiCHTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{PTN|NzFOwG0> NIrvTGFUSU6JRWK=
human D-263MG cell NI\US3pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLsTY5pcWKrdHnvckBw\iCqdX3hckBFNTJ4M13HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4{QDN{NzFOwG0> NVG4cWt4W0GQR1XS
human T98G cell MnTLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3npRmlvcGmkaYTpc44hd2ZiaIXtZY4hXDl6RzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|g5PTdizszN MkPFV2FPT0WU
human CTB-1 cell NFTkWZVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlnJTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|k4PjFizszN NWnC[lhFW0GQR1XS
human Hs-578-T cell NEHpZpRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{\aU2lvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? NFrWcVlUSU6JRWK=
human SF126 cell NYPPfo9LT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHNHOTJ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj60N|YzOSEQvF2= M4q0XHNCVkeHUh?=
human NCI-H460 cell MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWLJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KNE[wJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41Ozl3NTFOwG0> NUHpb2lbW0GQR1XS
human NCI-H1755 cell MmTWS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUe1OUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRyNEOg{txO M4Hlc3NCVkeHUh?=
human HL-60 cell NY\mXlV3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmT3TY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVQyPTlizszN NIPDc2dUSU6JRWK=
human G-401 cell NWX2fGU3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoHkTY5pcWKrdHnvckBw\iCqdX3hckBINTRyMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuOVYxQTlizszN MXPTRW5ITVJ?
human AGS cell MkX2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoHnTY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2NlU4KM7:TR?= M13o[3NCVkeHUh?=
human HuO9 cell M1\VT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFn5SpVKdmirYnn0bY9vKG:oIHj1cYFvKEi3T{mgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlU3PDV4IN88US=> MXXTRW5ITVJ?
human MFE-280 cell MnzCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGX0ZpNKdmirYnn0bY9vKG:oIHj1cYFvKE2IRT2yPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV4Nki2JO69VQ>? MnTuV2FPT0WU
human NCI-H292 cell Mor2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV;Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkmyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42Pzd{MjFOwG0> M3rSc3NCVkeHUh?=
human HuO-3N1 cell NGD0OVVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlTUTY5pcWKrdHnvckBw\iCqdX3hckBJfU9vM16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk43ODNyNzFOwG0> MnPnV2FPT0WU
human ES3 cell NHu4[o9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXHFbmJpUW6qaXLpeIlwdiCxZjDoeY1idiCHU{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYzOjh3IN88US=> NFH4SHJUSU6JRWK=
human LB2241-RCC cell M2TYe2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUW4TYh2UW6qaXLpeIlwdiCxZjDoeY1idiCOQkKyOFEuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62PVA4QSEQvF2= MorYV2FPT0WU
human NCI-H1155 cell M4TuSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1LXNGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVixNVU2KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi54OUSwOUDPxE1? NFuwRlVUSU6JRWK=
human SW872 cell MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVfxbllPUW6qaXLpeIlwdiCxZjDoeY1idiCVV{i3NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzB4N{[g{txO MVrTRW5ITVJ?
human MHH-ES-1 cell Mn3RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoXTTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvRWOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ4M{Og{txO NFLqNoxUSU6JRWK=
human KYSE-150 cell NXW4NnNGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYXJcohq[mm2aX;uJI9nKGi3bXHuJGt[W0VvMUWwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk44Ojl5IN88US=> MX3TRW5ITVJ?
human MC-IXC cell NI\0NotIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJG1ENUm[QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPFk2OyEQvF2= MkfaV2FPT0WU
human HCC1187 cell MoTTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1TwR2lvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUG4O{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQDl4N{eg{txO MkTZV2FPT0WU
human UMC-11 cell MnzIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2TiOmlvcGmkaYTpc44hd2ZiaIXtZY4hXU2FLUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk46ODR5NzFOwG0> NX:0TVN4W0GQR1XS
human NB5 cell NITsSZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH[2eWNKdmirYnn0bY9vKG:oIHj1cYFvKE6ENTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuPVM4OTVizszN M1XtfXNCVkeHUh?=
human A2058 cell NXrKd5pLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVTpZoszUW6qaXLpeIlwdiCxZjDoeY1idiCDMkC1PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvQTd6NESg{txO M2DFUXNCVkeHUh?=
human Becker cell NXvNfINkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF\iN5BKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMvODFzMUKg{txO NHz3c|VUSU6JRWK=
human CAS-1 cell M4fwbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M133VGlvcGmkaYTpc44hd2ZiaIXtZY4hS0GVLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlAyPTZ7IN88US=> M1vJfnNCVkeHUh?=
human SW780 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFLxOG5KdmirYnn0bY9vKG:oIHj1cYFvKFOZN{iwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4zPTZyOTFOwG0> Ml\PV2FPT0WU
human KM12 cell MkfFS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXT5fmhoUW6qaXLpeIlwdiCxZjDoeY1idiCNTUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4{ODF|MjFOwG0> NWSwU5BWW0GQR1XS
human PC-3 cell NH\zdGVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUfJcohq[mm2aX;uJI9nKGi3bXHuJHBENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkG3OFEyKM7:TR?= M1TQfXNCVkeHUh?=
human A253 cell MkD2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVzJcohq[mm2aX;uJI9nKGi3bXHuJGEzPTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkG4PFk{KM7:TR?= NUT4VFAxW0GQR1XS
human NB10 cell NVn6UW5sT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkfHTY5pcWKrdHnvckBw\iCqdX3hckBPSjFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6yNlc4OyEQvF2= NHPM[I1USU6JRWK=
human A172 cell M3;nR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXnJcohq[mm2aX;uJI9nKGi3bXHuJGEyPzJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkS0OVch|ryP M2[2OXNCVkeHUh?=
human A498 cell MnzRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFnRfnZKdmirYnn0bY9vKG:oIHj1cYFvKEF2OUigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlU3Ozh|IN88US=> M{jvZ3NCVkeHUh?=
human SW1573 cell NXL3S4tHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXHJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTV5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uPVA1QTFizszN NFXi[lZUSU6JRWK=
human 5637 cell NGf5VFNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEC4[YVKdmirYnn0bY9vKG:oIHj1cYFvKDV4M{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlA4QTB2IN88US=> MkTsV2FPT0WU
human A388 cell MlnLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjIVW5KdmirYnn0bY9vKG:oIHj1cYFvKEF|OEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yNU4yOzl6IN88US=> MmHyV2FPT0WU
human U251 cell NIe1XnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkTmTY5pcWKrdHnvckBw\iCqdX3hckBWOjVzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkiuNVE4PSEQvF2= NHTteGxUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
+ Expand

Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
+ Expand
  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID