BX-795

For research use only.

Catalog No.S1274

43 publications

BX-795 Chemical Structure

CAS No. 702675-74-9

BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1.

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Selleck's BX-795 has been cited by 43 publications

Purity & Quality Control

Choose Selective PDK Inhibitors

Biological Activity

Description BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1.
Targets
PDK-1 [1]
(Cell-free assay)
c-Kit [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
Chk1 [1]
(Cell-free assay)
6 nM 320 nM 430 nM 510 nM
In vitro

BX-795 effectively blocks PDK1 activity in PC-3 cells, as shown by their ability to block phosphorylation of S6K1, Akt, PKCδ, and GSK3β. BX-795 potently inhibits tumor cell growth on plastic with IC50 of 1.6, 1.4, and 1.9 μM for MDA-468, HCT-116 and MiaPaca cells, respectively. In soft agar, BX-795 displays higher growth inhibition with IC50 of 0.72, and 0.25 μM for MDA-468, and PC-3 cells, respectively. [1] In addition, BX-795, as an inhibitor of the TBK1/IKKɛ, blocks TBK1- and IKKε-mediated activation of IRF3 and production of IFN-β. [2] In platelet physiological responses, BX795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation, ATP secretion and thromboxane generation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MV-4-11 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjyTY5pcWKrdHnvckBw\iCqdX3hckBOXi12LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N|YvQCCwTR?= M2Ppc3NCVkeHUh?=
KRX cells MlvnSpVv[3Srb36gZZN{[Xl? NHLmWmY4KG2rboO= MnX4TY5pcWKrdHnvckBw\iCVVV3PMZRi\2enZDDVUGsyKCi3bnvuc5dvKG:{aXfpckkhc2mwYYPlJIRwdWGrbjDlfJBz\XO|ZXSgbY4hU1K[IHPlcIx{KHW|aX7nJHs{OlCfLXfhcY1iNUGWUDDhcoQhdXmnbHnuJIJie2mlIIDyc5RmcW5ic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhPyCvaX7z MXeyOlI4PTZ6MR?=
human NKM-1 cell NYHzcWh[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml7VTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuN|YyQTRizszN MXHTRW5ITVJ?
human P30-OHK cell NWLVdXhKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M37LeWlvcGmkaYTpc44hd2ZiaIXtZY4hWDNyLV;IT{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7LDDJR|UxRTBwNEm2OUDPxE1? Mly1V2FPT0WU
human YH-13 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MU\Jcohq[mm2aX;uJI9nKGi3bXHuJHlJNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD62Nlg5QCEQvF2= NVvRfZJNW0GQR1XS
human LXF-289 cell NWPhV4s4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1mwVGlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NiCLQ{WwQVAvPjV4OUOg{txO M162e3NCVkeHUh?=
human BE-13 cell NGPsRnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEXrW2RKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE44ODR5NzFOwG0> MXzTRW5ITVJ?
human RS4-11 cell M2DFXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHT1V4hKdmirYnn0bY9vKG:oIHj1cYFvKFKVND2xNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzJ3OUSg{txO MoLuV2FPT0WU
human A3-KAW cell M3fGeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkDqTY5pcWKrdHnvckBw\iCqdX3hckBCOy2NQWegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlc{ODV3IN88US=> MXnTRW5ITVJ?
human PA-1 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYrJcohq[mm2aX;uJI9nKGi3bXHuJHBCNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkiwOFIzKM7:TR?= NU[4R|YyW0GQR1XS
human ES7 cell M{GxeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJGVUPyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwOEO1OlYh|ryP NVnUOIhjW0GQR1XS
human ES8 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjrO2NKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuPFQ{OzZizszN M1HEPXNCVkeHUh?=
human SW982 cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJHNYQTh{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD65OVEzPCEQvF2= MnO5V2FPT0WU
human VA-ES-BJ cell M4Xzd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmjzTY5pcWKrdHnvckBw\iCqdX3hckBXSS2HUz3CTkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTh2Nkeg{txO MV\TRW5ITVJ?
human 697 cell NWG2e|hlT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vuR2lvcGmkaYTpc44hd2ZiaIXtZY4hPjl5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wNVYzOyEQvF2= NWjSclRrW0GQR1XS
human MOLT-4 cell NHHqdIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUX6XohLUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB|MkS0JO69VQ>? NFvocI9USU6JRWK=
human D-283MED cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHHsW3ZKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yM{m0PEDPpG1? M2n4TnNCVkeHUh?=
human ALL-PO cell NYH1NmlET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnvUTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA3ODd|IN88US=> M4Ha[HNCVkeHUh?=
human NB14 cell MmnvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn35TY5pcWKrdHnvckBw\iCqdX3hckBPSjF2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6wOlA5OSEQvF2= M{DBOnNCVkeHUh?=
human NTERA-S-cl-D1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVnJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC3O|c2KM7:TR?= M33GNnNCVkeHUh?=
human BFTC-905 cell NXjjfYhkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlPXTY5pcWKrdHnvckBw\iCqdX3hckBDTlSFLUmwOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvODhzMEGg{txO MVLTRW5ITVJ?
human H4 cell NWn5NnFST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NITVU3FKdmirYnn0bY9vKG:oIHj1cYFvKEh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xNFIxOSEQvF2= MoH4V2FPT0WU
human CHP-212 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXzMdHRRUW6qaXLpeIlwdiCxZjDoeY1idiCFSGCtNlEzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zNECzO{DPxE1? NHrTWHRUSU6JRWK=
human A204 cell MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGEzODRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkG1OFY4KM7:TR?= NYDROoR2W0GQR1XS
human NB69 cell MlvOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1PJNGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJ4OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuNVU5PjVizszN NGrz[G1USU6JRWK=
human P12-ICHIKAWA cell NXTwXmZPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJHAyOi2LQ1jJT2FYSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwMUixO|Eh|ryP MknhV2FPT0WU
human L-363 cell MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xPFE6PyEQvF2= Ml\2V2FPT0WU
human ES5 cell NUPndZZZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLLOZNnUW6qaXLpeIlwdiCxZjDoeY1idiCHU{WgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlE6OzV2IN88US=> MVnTRW5ITVJ?
human CAL-51 cell NHfHdVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrVXYpQUW6qaXLpeIlwdiCxZjDoeY1idiCFQVytOVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ{MUW2JO69VQ>? NF;TemRUSU6JRWK=
human NBsusSR cell MmDDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoHHTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4zPDV5ODFOwG0> MVrTRW5ITVJ?
human HOP-92 cell M2LleGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfMVlVtUW6qaXLpeIlwdiCxZjDoeY1idiCKT2CtPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ5MkmzJO69VQ>? MUPTRW5ITVJ?
human DU-4475 cell MnntS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHXPVZJKdmirYnn0bY9vKG:oIHj1cYFvKESXLUS0O|Uh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjJ7MkS1JO69VQ>? M3L5WHNCVkeHUh?=
human LB1047-RCC cell M{HkcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXf6RpBGUW6qaXLpeIlwdiCxZjDoeY1idiCOQkGwOFcuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6yPVI5OSEQvF2= MmC0V2FPT0WU
human D-566MG cell M3nVbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1LSZ2lvcGmkaYTpc44hd2ZiaIXtZY4hTC13Nk\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvOzB2NEig{txO MX;TRW5ITVJ?
human A375 cell M33mR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnnhTY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6zNFg2QCEQvF2= M2\VOXNCVkeHUh?=
human ATN-1 cell MnfKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFnIbY9KdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4{PzF6NTFOwG0> NFu0VIFUSU6JRWK=
human M059J cell M2DHZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlzjTY5pcWKrdHnvckBw\iCqdX3hckBOODV7SjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuN|c3PTJizszN Ml:zV2FPT0WU
human HSC-3 cell M{fyXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUfJcohq[mm2aX;uJI9nKGi3bXHuJGhUSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT60OFIxQCEQvF2= MWnTRW5ITVJ?
human DOHH-2 cell MmDxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvCfoVKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDV6MUSg{txO M4rKe3NCVkeHUh?=
human G-402 cell MlSzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHny[HpKdmirYnn0bY9vKG:oIHj1cYFvKEdvNECyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PjV{NTFOwG0> NF7KPZBUSU6JRWK=
human LC-2-ad cell Mn3vS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGX1SZhKdmirYnn0bY9vKG:oIHj1cYFvKEyFLUKtZYQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjR5MUOyJO69VQ>? NFTESHhUSU6JRWK=
human LOXIMVI cell M1;ZZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVnJcohq[mm2aX;uJI9nKGi3bXHuJGxQYEmPVlmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlUxPTV{IN88US=> NV3LTVlRW0GQR1XS
human DK-MG cell NXHWR|lHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV;iSoUyUW6qaXLpeIlwdiCxZjDoeY1idiCGSz3NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTd{OUig{txO MlewV2FPT0WU
human HOS cell NWnwSXdTT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvWTY5pcWKrdHnvckBw\iCqdX3hckBJV1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkW3N|A6KM7:TR?= NFfCOmVUSU6JRWK=
human BHT-101 cell NWPWT5liT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Moi1TY5pcWKrdHnvckBw\iCqdX3hckBDUFRvMUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42Pzh5NzFOwG0> MlHZV2FPT0WU
human U-2-OS cell Mne4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFq3XYxKdmirYnn0bY9vKG:oIHj1cYFvKFVvMj3PV{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPTh6ME[g{txO NVfWPY52W0GQR1XS
human D-423MG cell NY\xWVBNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4fIdGlvcGmkaYTpc44hd2ZiaIXtZY4hTC12MkPNS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjB6ME[g{txO NGHBV2JUSU6JRWK=
human AN3-CA cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWnqdm81UW6qaXLpeIlwdiCxZjDoeY1idiCDTkOtR2Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ|OUmxJO69VQ>? NUXtd5Z6W0GQR1XS
human TE-11 cell MnXRS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYXJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTFzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT62OVI5KM7:TR?= NHvFRoZUSU6JRWK=
human SK-NEP-1 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{\q[GlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjZ3M{e2JO69VQ>? NE\PcmlUSU6JRWK=
human MG-63 cell M3H5PGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX\YOYVuUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPjh3Nkeg{txO MYPTRW5ITVJ?
human RH-1 cell MmPLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIXuSoRKdmirYnn0bY9vKG:oIHj1cYFvKFKKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlcxOjd2IN88US=> M2riUHNCVkeHUh?=
human MDA-MB-157 cell NHyzRmhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX\jTlRQUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOTV5IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63NVY4PCEQvF2= NVTyfG5mW0GQR1XS
human A427 cell NEXMbpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYDJcohq[mm2aX;uJI9nKGi3bXHuJGE1OjdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkezOVg6KM7:TR?= MVPTRW5ITVJ?
human ES1 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1i1d2lvcGmkaYTpc44hd2ZiaIXtZY4hTVNzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT63OVQ2OSEQvF2= NFrHOFdUSU6JRWK=
human C32 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnJcohq[mm2aX;uJI9nKGi3bXHuJGM{OiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwN{[zPUDPxE1? MUXTRW5ITVJ?
human LAMA-84 cell MknzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn\tTY5pcWKrdHnvckBw\iCqdX3hckBNSU2DLUi0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU44Pjh5MjFOwG0> NVWyUlkyW0GQR1XS
human YKG-1 cell M1u5Xmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3yzXmlvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlc4OTJ2IN88US=> M{PSOnNCVkeHUh?=
human NCI-H1048 cell M3fk[Gdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXPJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUC0PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPzh3MEmg{txO M2nTenNCVkeHUh?=
human KS-1 cell NGDY[VlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fvWGlvcGmkaYTpc44hd2ZiaIXtZY4hU1NvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuPFI6QCEQvF2= NUXXSFFWW0GQR1XS
human JVM-3 cell MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1X4TGlvcGmkaYTpc44hd2ZiaIXtZY4hUl[PLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlg3PDlzIN88US=> MlPZV2FPT0WU
human GI-ME-N cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHTlTHVKdmirYnn0bY9vKG:oIHj1cYFvKEeLLV3FMW4h[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjh4NUOg{txO NYC2bXQ6W0GQR1XS
human GT3TKB cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{nFWmlvcGmkaYTpc44hd2ZiaIXtZY4hT1R|VFvCJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU45QTZ2MjFOwG0> M{PJPXNCVkeHUh?=
human CHL-1 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFK2OoVKdmirYnn0bY9vKG:oIHj1cYFvKEOKTD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46OjN5OTFOwG0> MV\TRW5ITVJ?
human CHP-134 cell NWH4R2J7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoqwTY5pcWKrdHnvckBw\iCqdX3hckBEUFBvMUO0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU46PDR4NzFOwG0> NVv3O5RYW0GQR1XS
human 8-MG-BA cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHG1bG5KdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl3N{S0JO69VQ>? MXPTRW5ITVJ?
human HO-1-N-1 cell NXj0OmF7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGTkUXVKdmirYnn0bY9vKG:oIHj1cYFvKEiRLUGtUk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS57N{GxO{DPxE1? M1\jWnNCVkeHUh?=
human SW1088 cell NEPvUHBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWX5dmhKUW6qaXLpeIlwdiCxZjDoeY1idiCVV{GwPFgh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjl7NkezJO69VQ>? Ml;JV2FPT0WU
human SW48 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1O5[2lvcGmkaYTpc44hd2ZiaIXtZY4hW1d2ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNFIxPjdizszN MWLTRW5ITVJ?
human VM-CUB-1 cell NXnhbVZqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlPnTY5pcWKrdHnvckBw\iCqdX3hckBXVS2FVVKtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvODRzMUmg{txO MnLzV2FPT0WU
human COLO-800 cell NF;YXFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHvYemZKdmirYnn0bY9vKG:oIHj1cYFvKEORTF:tPFAxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5yNUGzOkDPxE1? NV3FNVVnW0GQR1XS
human TI-73 cell MorlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4PlcGlvcGmkaYTpc44hd2ZiaIXtZY4hXElvN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlEyOzl7IN88US=> M2m2ZXNCVkeHUh?=
human HN cell NIS0cWVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{nJSmlvcGmkaYTpc44hd2ZiaIXtZY4hUE5iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyNVk5KM7:TR?= M{PrOnNCVkeHUh?=
human DB cell NV3oZoc4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jqUmlvcGmkaYTpc44hd2ZiaIXtZY4hTEJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGyOlMyKM7:TR?= M13BN3NCVkeHUh?=
human Ca9-22 cell NX3sdGhqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4CyUmlvcGmkaYTpc44hd2ZiaIXtZY4hS2F7LUKyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4yOjh2NzFOwG0> MXPTRW5ITVJ?
human A549 cell MoXCS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MULJcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkGzPFA5KM7:TR?= M3\EUHNCVkeHUh?=
human KGN cell M2jlS2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHW1O3dKdmirYnn0bY9vKG:oIHj1cYFvKEuJTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlI2QTVizszN M4TpVXNCVkeHUh?=
human BCPAP cell NXnUZ41uT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlXWTY5pcWKrdHnvckBw\iCqdX3hckBDS1CDUDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuNlMyPThizszN M1zoSnNCVkeHUh?=
human Ramos-2G6-4C10 cell NX;xOJVGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVHN[XlvUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvOjN5NUmg{txO NGHyOXZUSU6JRWK=
human OVCAR-5 cell NH;hT4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWfVSpdMUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{N{ezOEDPxE1? NFOzWWVUSU6JRWK=
human KG-1 cell M2\YXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYj6PWNQUW6qaXLpeIlwdiCxZjDoeY1idiCNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPzd7MjFOwG0> NX3ESFFrW0GQR1XS
human CAKI-1 cell MVfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NUTvNodTUW6qaXLpeIlwdiCxZjDoeY1idiCFQVvJMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjJ6MEW4JO69VQ>? M2PWcXNCVkeHUh?=
human QIMR-WIL cell NX3T[oVGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUG5SItjUW6qaXLpeIlwdiCxZjDoeY1idiCTSV3SMXdKVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwMki3OFQh|ryP NH\UVFBUSU6JRWK=
human SW1710 cell M2LmVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlnXTY5pcWKrdHnvckBw\iCqdX3hckBUXzF5MUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlI6OTR{IN88US=> M2n1cnNCVkeHUh?=
human SK-UT-1 cell NXXzcIQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWr4NG5rUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3VWE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{OUOzPUDPxE1? MV7TRW5ITVJ?
human IST-SL1 cell M3vrOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlMzOTd2IN88US=> NVnkOoVuW0GQR1XS
human SW962 cell MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDHTY5pcWKrdHnvckBw\iCqdX3hckBUXzl4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|M4PTdizszN NFXtNWFUSU6JRWK=
human EM-2 cell MnyxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3XoeGlvcGmkaYTpc44hd2ZiaIXtZY4hTU1vMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|U{OzdizszN MV3TRW5ITVJ?
human D-263MG cell NYTrO2tET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NE\TOVhKdmirYnn0bY9vKG:oIHj1cYFvKERvMk[zUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjN6M{K3JO69VQ>? NUXlXFJKW0GQR1XS
human T98G cell MVvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3XNXGlvcGmkaYTpc44hd2ZiaIXtZY4hXDl6RzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUKuN|g5PTdizszN MnTJV2FPT0WU
human CTB-1 cell NWPXdJNNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MVfJcohq[mm2aX;uJI9nKGi3bXHuJGNVSi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6zPVc3OSEQvF2= NUHscZZXW0GQR1XS
human Hs-578-T cell M3jXPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{nhTWlvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjRzNUi3JO69VQ>? MmPVV2FPT0WU
human SF126 cell NI\lPXJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEDjcFhKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk41OzZ{MTFOwG0> M3jN[HNCVkeHUh?=
human NCI-H460 cell NWDrW3dpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIfNeWxKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOFYxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi52M{m1OUDPxE1? NEjHO2lUSU6JRWK=
human NCI-H1755 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjiNopiUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE4PTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW0NFQ{KM7:TR?= NGPSb3NUSU6JRWK=
human HL-60 cell NVrhNpMyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnBeVZ{UW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTRzNUmg{txO MWHTRW5ITVJ?
human G-401 cell NEXhXoZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV3KZVBuUW6qaXLpeIlwdiCxZjDoeY1idiCJLUSwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZyOUmg{txO NEDGdItUSU6JRWK=
human AGS cell M{\vVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mnu1TY5pcWKrdHnvckBw\iCqdX3hckBCT1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW2NlU4KM7:TR?= NGT4d4JUSU6JRWK=
human HuO9 cell MlWwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnO0TY5pcWKrdHnvckBw\iCqdX3hckBJfU97IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj61OlQ2PiEQvF2= NWr0emRxW0GQR1XS
human MFE-280 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1qxcWlvcGmkaYTpc44hd2ZiaIXtZY4hVU[HLUK4NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPTZ4OE[g{txO MV7TRW5ITVJ?
human NCI-H292 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1HBemlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyPVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjV5N{KyJO69VQ>? NXXOc2N7W0GQR1XS
human HuO-3N1 cell M3Oxdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2PtbWlvcGmkaYTpc44hd2ZiaIXtZY4hUHWRLUPONUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPjB|MEeg{txO MWDTRW5ITVJ?
human ES3 cell NVO4T4o4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NY\PeYE3UW6qaXLpeIlwdiCxZjDoeY1idiCHU{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlYzOjh3IN88US=> NWjEN4d[W0GQR1XS
human LB2241-RCC cell M3\mTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV7kfVBrUW6qaXLpeIlwdiCxZjDoeY1idiCOQkKyOFEuWkOFIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj62PVA4QSEQvF2= MXvTRW5ITVJ?
human NCI-H1155 cell NFnMeIpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXj3d|FOUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFEyPTViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[5OFA2KM7:TR?= NEnZ[Y5USU6JRWK=
human SW872 cell NUHSSVl3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MX7Jcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj63NFY4PiEQvF2= MXnTRW5ITVJ?
human MHH-ES-1 cell NIP4flFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLjeZFKdmirYnn0bY9vKG:oIHj1cYFvKE2KSD3FV{0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi55Mk[zN{DPxE1? MXnTRW5ITVJ?
human KYSE-150 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlHRTY5pcWKrdHnvckBw\iCqdX3hckBMYVOHLUG1NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIvPzJ7NzFOwG0> NFjRSolUSU6JRWK=
human MC-IXC cell NYTMN5VKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jOOGlvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk45QTV|IN88US=> NWfhZo5kW0GQR1XS
human HCC1187 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEnXfJJKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{GxPFch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zNjh7Nke3JO69VQ>? NVzzSIR{W0GQR1XS
human UMC-11 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlK4TY5pcWKrdHnvckBw\iCqdX3hckBWVUNvMUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlkxPDd5IN88US=> MmXVV2FPT0WU
human NB5 cell NWC3U4pmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWTJcohq[mm2aX;uJI9nKGi3bXHuJG5DPSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwOUO3NVUh|ryP MlS5V2FPT0WU
human A2058 cell MlqxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MV\Jcohq[mm2aX;uJI9nKGi3bXHuJGEzODV6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj65O|g1PCEQvF2= MnHZV2FPT0WU
human Becker cell NULZW5pNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3n4fmlvcGmkaYTpc44hd2ZiaIXtZY4hSmWla3XyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4xOTFzMjFOwG0> MYLTRW5ITVJ?
human CAS-1 cell M{LmbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYfJcohq[mm2aX;uJI9nKGi3bXHuJGNCWy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6wNVU3QSEQvF2= NH\ubFFUSU6JRWK=
human SW780 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkXhTY5pcWKrdHnvckBw\iCqdX3hckBUXzd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuNlU3ODlizszN MV3TRW5ITVJ?
human KM12 cell NYrkcWhNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NF;xR49KdmirYnn0bY9vKG:oIHj1cYFvKEuPMUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlMxOTN{IN88US=> NH\EPWhUSU6JRWK=
human PC-3 cell NH63U|dIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml7kTY5pcWKrdHnvckBw\iCqdX3hckBRSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xO|QyOSEQvF2= NXvNO|JRW0GQR1XS
human A253 cell NYnBbZN1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX;hNFBIUW6qaXLpeIlwdiCxZjDoeY1idiCDMkWzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yQDh7MzFOwG0> NITseG1USU6JRWK=
human NB10 cell Mor6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHvhRoNKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlIzPzd|IN88US=> MWrTRW5ITVJ?
human A172 cell MmS3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoLVTY5pcWKrdHnvckBw\iCqdX3hckBCOTd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND60OFU4KM7:TR?= M4iyVXNCVkeHUh?=
human A498 cell MmLDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2rDeGlvcGmkaYTpc44hd2ZiaIXtZY4hSTR7ODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOVY{QDNizszN MnHRV2FPT0WU
human SW1573 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWroZ|VlUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G1O|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03NjlyNEmxJO69VQ>? MUXTRW5ITVJ?
human 5637 cell NH:wXVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NU\obldVUW6qaXLpeIlwdiCxZjDoeY1idiB3NkO3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4xPzlyNDFOwG0> MlfXV2FPT0WU
human A388 cell M{nHU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoSxTY5pcWKrdHnvckBw\iCqdX3hckBCOzh6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MkGuNVM6QCEQvF2= MlfmV2FPT0WU
human U251 cell Mlf0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYP5d2h3UW6qaXLpeIlwdiCxZjDoeY1idiCXMkWxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlgvOTF5NTFOwG0> NVLETplGW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-p38 / p38 / p-JNK / JNK / gD-2 ; 

PubMed: 28112176     


BX-795 inhibition on HSV replication attenuated by overexpression of p38/JNK. HeLa cells with or without JNK1 or p38 overexpression were infected with HSV-2 and total cellular protein was prepared for WB analysis. gD-2, the phosphorylation level of p38 MA䲧疝Ỵ疞㧀疜膉痘 瘿뙠ෆᾰƌෆĀ 㺣痖帉痖Ѐ瑖堘

pTBK1 / TBK1 / pPLK1 / PLK1; 

PubMed: 26772203     


TBK1 mediated activation of the mitotic kinase PLK1. SW210.5 cells were treated with indicated TBK1 inhibitors for 1 hour and then exposed to 50 ng/mL of nocodazole for 18 hours. Western blot detected the signaling change using indicated antibodies, and β䲧疝Ỵ疞㧀疜膉痘 瘿⟸෕ᾰƌ෕Ð 㺣痖帉痖Ѐ

28112176 26772203
Growth inhibition assay
Cell viability ; 

PubMed: 26772203     


Four SCLC cell lines with no MYC amplification were treated with TBK1 inhibitor BX-795 at the titration concentration. Cell viability was performed by CellTiter Glo 4 days after treatment. The growth curve was constructed by GraphPad Prism 6. 

26772203

Protocol

Kinase Assay:[1]
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Kinase assays:

PDK1 is assayed in a direct kinase assay and a coupled assay format measuring PDK1- and PtdIns-3,4-P2-mediated activation of AKT2. For the coupled assay, the final assay mixture (60 μL) contained: 15 mM MOPS, pH 7.2, 1 mg/mL bovine serum albumin, 18 mM β-glycerol phosphate, 0.7 mM dithiothreitol, 3 mM EGTA, 10 mM MgOAc, 7.5 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM biotinylated peptide substrate (biotin-ARRRDGGGAQPFRPRAATF), 0.5 μL of PtdIns-3,4-P2-containing phospholipid vesicles, 60 pg of purified recombinant human PDK1, and 172 ng of purified recombinant human AKT2. After incubation for 2 h at room temperature, the biotin-labeled peptide is captured from 10 μl of the assay mixture on streptavidin-coated SPA beads, and product formation is measured by scintillation proximity in a Wallac MicroBeta counter. The product formed is proportional to the time of incubation and to the amount of PDK1 and inactive AKT2 added. PDK1 is added at suboptimal levels so that the assay could sensitively detect inhibitors of AKT2 activation as well as direct inhibitors of PDK1 or AKT2. To measure PDK1 activity directly, the final assay mixture (60 μL) contained 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1 mM EDTA, 0.1% β-mercaptoethanol, 1 mg/mL bovine serum albumin, 10 mM MgOAc, 10 μM ATP, 0.2 μCi of [γ-33P]ATP, 7.5 μM substrate peptide (H2N-ARRRGVTTKTFCGT), and 60 ng of purified recombinant human PDK1. After 4 h at room temperature, we add 25 mM EDTA and spotted a portion of the reaction mixture on Whatman P81 phosphocellulose paper. The filter paper is washed three times with 0.75% phosphoric acid and once with acetone. After drying, the filter-bound labeled peptide is quantified using a Fuji phosphorimager.
Cell Research:[1]
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  • Cell lines: MDA-468, PC-3, HCT-116 and MiaPaca cells
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method: Cells seeded at a low density (1,500–3,000 cells/well, 0.1 mL/well, 96-well plates) are incubated overnight. Compound treatments are made by adding 10 μL/well of the compound in 1% dimethyl sulfoxide and growth medium (final concentration of dimethyl sulfoxide, 0.1%), followed by brief shaking. Treated cells are incubated for 72 hours, and viability is measured by the addition of 10 μL of the metabolic dye WST-1. The WST-1 signal is read in a plate reader at 450 nm, and a no cell, or zero time cell, background is subtracted to calculate the net signal. Results are reported as the average ± S.E. of two or more replicates.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (169.07 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG +2% Tween 80+ddH2O
For best results, use promptly after mixing.
4mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 591.47
Formula

C23H26IN7O2S

CAS No. 702675-74-9
Storage powder
in solvent
Synonyms N/A
Smiles C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S1274 for animal studies?

  • Answer:

    We recommend to use the vehicle 2% DMSO+30% PEG +2% Tween 80+ddH2O for in vivo study.

PDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID