Nilotinib hydrochloride monohydrate

Catalog No.S4895 Synonyms: Tasigna, AMN-107 hydrochloride monohydrate

For research use only.

Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.

Nilotinib hydrochloride monohydrate Chemical Structure

CAS No. 923288-90-8

Selleck's Nilotinib hydrochloride monohydrate has been cited by 9 Publications

Purity & Quality Control

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Biological Activity

Description Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition.
Targets
AMPK [1]
()
Bcr-Abl [1]
(in Murine myeloid progenitor cells)
30 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(171.23 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 583.99
Formula

C28H25ClF3N7O2

CAS No. 923288-90-8
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05185947 Not yet recruiting Drug: Paclitaxel|Drug: Nilotinib Peritoneal Carcinomatosis|Peritoneal Neoplasms|Ovarian Cancer|Ovarian Neoplasms|Colorectal Cancer|Colorectal Neoplasms|Appendiceal Cancer|Appendiceal Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 18 2022 Phase 2
NCT04326933 Not yet recruiting Drug: Tyrosine kinase Inhibitors (Imatinib & Nilotinib) Patients Diagnosed as Chronic Meyloid Leukemia Assiut University October 20 2020 --
NCT04002674 Recruiting Drug: Placebo oral capsule|Drug: Nilotinib Oral Capsule Dementia With Lewy Bodies Georgetown University|National Institutes of Health (NIH) January 10 2020 Phase 2
NCT03942094 Recruiting Drug: Nilotinib Chronic Myeloid Leukemia Chronic Phase|Nilotinib Shenzhen Second People''s Hospital|Zhongshan City People''s Hospital|Affiliated Hospital of Guangdong Medical University|Huazhong University of Science and Technology Union Shenzhen Hospital|Dongguan People''s Hospital|Longgang District Central Hospital of Shenzhen June 1 2019 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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