Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

Size Price Stock Quantity  
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 84 Publications

11 Customer Reviews

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei M3nNU2FvfGmvaXPyc4Jq[WxiQYPzZZk> NX;wbHNsOThiaB?= MXrEUXNQ NEDQe3dCdnSrdIL5dIFvd3OxbXHsJIFkfGm4aYT5JJdqfGhiRVO1NEBw\iByLkCwNlUh|ryP M37EdFI1QDB3OUS2
MCF7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXiwMlAyNTFyMDFOwG0> NYqwbHFZPDhiaB?= M1vDUWROW09? NICyeJBKSzVyPUCuO|Mh|ryP MV:yN|g4OTlyNB?=
HCT116 NUDaUXlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXywMlAyNTFyMDFOwG0> NFjS[nM1QCCq NWLPZnNqTE2VTx?= MXrJR|UxRTFwMU[g{txO NV3RemFIOjN6N{G5NFQ>
U87MG MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTCNE4xOS1zMECg{txO MoPZOFghcA>? M2q1c2ROW09? MU\JR|UxRTFwM{Kg{txO NEnhOm8zOzh5MUmwOC=>
HBC4 NYrhUmFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXqeldmOC5yMT2xNFAh|ryP MXu0PEBp Mof6UI9oKEeLNUC9MVgvPjFiTR?= MUCyNlM{PjJ2Nh?=
BSY1 M2HkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:wMlAyNTFyMDFOwG0> NWjCSHhmPDhiaB?= MmfiUI9oKEeLNUC9MVgvPDhiTR?= MkXFNlI{OzZ{NE[=
HBC5 NXzWcnB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHoS|JWOC5yMT2xNFAh|ryP M4ex[|Q5KGh? MW\Mc4chT0l3ME2tO{45PyCP M2LxblIzOzN4MkS2
MCF7 NF3h[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHYTWExNjBzLUGwNEDPxE1? NVmye2g2PDhiaB?= MkXMUI9oKEeLNUC9MVgvOTZiTR?= NEPoS5kzOjN|NkK0Oi=>
MDA-MB-231 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHqbIRJOC5yMT2xNFAh|ryP NV62WWhpPDhiaB?= NYCwXZhuVG:pIFfJOVA:NThwMEmgUS=> NHSwOnYzOjN|NkK0Oi=>
U251 NGnlZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHCNE4xOS1zMECg{txO NHTIUJo1QCCq MX\Mc4chT0l3ME2tO{43PiCP MVqyNlM{PjJ2Nh?=
SF268 NIfjPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nGOVAvODFvMUCwJO69VQ>? M1zJfFQ5KGh? NF:2TWhNd2diR1m1NF0uPy57MjDN MmLiNlI{OzZ{NE[=
SF295 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\NUVAvODFvMUCwJO69VQ>? NIDkTWg1QCCq M4D1N2xw\yCJSUWwQU05NjNzIF2= Mn\wNlI{OzZ{NE[=
SF539 M3u2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHTfW4xNjBzLUGwNEDPxE1? MmjKOFghcA>? NITj[W1Nd2diR1m1NF0uQC53OTDN NHnMWpozOjN|NkK0Oi=>
SNB75 MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjLfodUOC5yMT2xNFAh|ryP MknmOFghcA>? NX7DTVdPVG:pIFfJOVA:NThwNUigUS=> NFHnTlczOjN|NkK0Oi=>
SNB78 M3\RRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV:wMlAyNTFyMDFOwG0> M{HufVQ5KGh? NEf2Z5NNd2diR1m1NF0uQC54NTDN M{[5dlIzOzN4MkS2
HCC2998 MmLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr1OXMxNjBzLUGwNEDPxE1? NVf4Voo6PDhiaB?= M3yxbGxw\yCJSUWwQU05NjB3IF2= Mn\PNlI{OzZ{NE[=
KM12 M3X1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLmZ4kxNjBzLUGwNEDPxE1? MkTKOFghcA>? M1;mRmxw\yCJSUWwQU04NjV2IF2= NFTEdZgzOjN|NkK0Oi=>
HT-29 NWDDNoY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjONE4xOS1zMECg{txO MlzPOFghcA>? M2\jXWxw\yCJSUWwQU04Njd3IF2= MUOyNlM{PjJ2Nh?=
HCT15 NETse2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHLUWpGOC5yMT2xNFAh|ryP Mk\IOFghcA>? NGi5SohNd2diR1m1NF0uQC5yMzDN NGSxWnIzOjN|NkK0Oi=>
HCT116 NHvtXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPiNE4xOS1zMECg{txO Mn7vOFghcA>? NHPYXpBNd2diR1m1NF0uPy54MTDN M3u5N|IzOzN4MkS2
NCI-H23 NFzCS2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17TeVAvODFvMUCwJO69VQ>? M1ToXlQ5KGh? NUXi[ZNEVG:pIFfJOVA:NTdwNkSgUS=> MViyNlM{PjJ2Nh?=
NCI-H226 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7ONE4xOS1zMECg{txO MlzMOFghcA>? MWjMc4chT0l3ME2tPE41PCCP NGjWbIkzOjN|NkK0Oi=>
NCI-H522 NUTqV5k5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLrNE4xOS1zMECg{txO MYi0PEBp NYfJUHZ3VG:pIFfJOVA:NThwNEWgUS=> NE\UflMzOjN|NkK0Oi=>
NCI-H438 MnP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[xbIJDOC5yMT2xNFAh|ryP NVziWVZJPDhiaB?= M{LXV2xw\yCJSUWwQU05NjFzIF2= NGTIfFkzOjN|NkK0Oi=>
A549 NF2zVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfCZWtEOC5yMT2xNFAh|ryP MmL4OFghcA>? M1LDTmxw\yCJSUWwQU05NjB5IF2= MYCyNlM{PjJ2Nh?=
DMS273 NFPncJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjZc4k1OC5yMT2xNFAh|ryP NYXGZXhYPDhiaB?= Mk[5UI9oKEeLNUC9MVcvQDBiTR?= NYrPW2hHOjJ|M{[yOFY>
DMS114 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn36NE4xOS1zMECg{txO MlXiOFghcA>? M4PkU2xw\yCJSUWwQU05NjN7IF2= MkXENlI{OzZ{NE[=
LOXIMVI NGDKd49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XRNVAvODFvMUCwJO69VQ>? M3PJSVQ5KGh? MlHYUI9oKEeLNUC9MVgvPjZiTR?= NFXjZ3EzOjN|NkK0Oi=>
OVCAR3 Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3TcHcxNjBzLUGwNEDPxE1? NGTjTJE1QCCq NYGwOJF[VG:pIFfJOVA:NThwMUegUS=> Mn30NlI{OzZ{NE[=
OVCAR4 NGnBd5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLMeWYxNjBzLUGwNEDPxE1? NXjRT|QxPDhiaB?= NILLc3ZNd2diR1m1NF0uQC53ODDN MoDFNlI{OzZ{NE[=
OVCAR5 NFHlW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n0OFAvODFvMUCwJO69VQ>? M1ryclQ5KGh? MnPhUI9oKEeLNUC9MVcvPTdiTR?= NELsPHAzOjN|NkK0Oi=>
OVCAR8 MnTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;5PJhOOC5yMT2xNFAh|ryP MUK0PEBp MVvMc4chT0l3ME2tO{45PCCP NUfKT2FkOjJ|M{[yOFY>
SKOV3 MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXuwMlAyNTFyMDFOwG0> M3zVTFQ5KGh? NIHvcopNd2diR1m1NF0uQC52MTDN MnzGNlI{OzZ{NE[=
RXF631L M2m4e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnBSWVWOC5yMT2xNFAh|ryP Ml3YOFghcA>? NW\ldWx{VG:pIFfJOVA:NThwMkGgUS=> NX71ZVB{OjJ|M{[yOFY>
ACHN NFjYeXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DwW|AvODFvMUCwJO69VQ>? NYr5WZEzPDhiaB?= M2LCdmxw\yCJSUWwQU04Njl3IF2= MoW4NlI{OzZ{NE[=
St-4 NVT6e2JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvWNE4xOS1zMECg{txO M1m0RlQ5KGh? NH2xTmlNd2diR1m1NF0uPy52NzDN MYOyNlM{PjJ2Nh?=
MKN1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzkWoExNjBzLUGwNEDPxE1? Mn35OFghcA>? M{LxSmxw\yCJSUWwQU05NjRzIF2= NVW1NIJVOjJ|M{[yOFY>
MKN7 NV7DN4pvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH1WpY1OC5yMT2xNFAh|ryP M4PHU|Q5KGh? NHrrNpNNd2diR1m1NF0uPy54ODDN MnXONlI{OzZ{NE[=
MKN28 NGrsfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m5R|AvODFvMUCwJO69VQ>? MWS0PEBp M4nyUWxw\yCJSUWwQU04NjB5IF2= MnfBNlI{OzZ{NE[=
MKN45 NF3Xd|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXJS3UxNjBzLUGwNEDPxE1? M1qxOVQ5KGh? MYfMc4chT0l3ME2tPE4{PCCP NFLrR|YzOjN|NkK0Oi=>
MKN74 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[zbVAvODFvMUCwJO69VQ>? MXq0PEBp NGnMXFJNd2diR1m1NF0uPy52MjDN M3zTflIzOzN4MkS2
DU145 NU\YRnRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f0TFAvODFvMUCwJO69VQ>? NILy[Gs1QCCq NV\kfmFrVG:pIFfJOVA:NThwMU[gUS=> NVyxR2h3OjJ|M{[yOFY>
PC3 MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnH[2tDOC5yMT2xNFAh|ryP NXT4fYQzPDhiaB?= MVvMc4chT0l3ME2tPE43PiCP MVSyNlM{PjJ2Nh?=
Trypanosoma brucei brucei M2DQ[2Z2dmO2aX;uJGF{e2G7 M3\iZlIxOCCwTR?= MX6xNkBp MXHEUXNQ M3zQV2Rm[3KnYYPlJIlvKHCqb4PwbI91cWS7bDDpco9{cXSxbDDwbI9{eGijdHWgcIV3\Wx? M37L[VI1QDB3OUS2
Trypanosoma brucei brucei NVjjeHU4TnWwY4Tpc44hSXO|YYm= NHL5Oo0yQCCq NXG2cZJqTE2VTx?= NWnsU|dJUW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= MlfkNlQ5ODV7NE[=
Trypanosoma brucei brucei MXXGeY5kfGmxbjDBd5NigQ>? MWOyNFAhdk1? M3r1UVEzKGh? NGC2eIRFVVOR NG\DPXJG\m[nY4Sgc44he3CqaX7nc416dGWrbjDs[ZZmdA>? NIi1TmozPDhyNUm0Oi=>
Trypanosoma brucei brucei NFHaR3hHfW6ldHnvckBCe3OjeR?= MmH1NlAxKG6P NILxWnkyOiCq M1vJTWROW09? MoLkSYZn\WO2IH;uJJBpd3OyaHH0bYR6dGOqb3zpcoUhdGW4ZXy= NYfKZnkxOjR6MEW5OFY>
UM-UC-3 NF7CRVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNzNTDwUS=> M3SxTnNCVkeHUh?=
SBC-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7HTWM2OD15NEKgdG0> M1izXXNCVkeHUh?=
MKN1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTJwODDuUS=> MnvjV2FPT0WU
NCI-H720 NWT2N2VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j5Z2lEPTB;Mz61O{BvVQ>? M{XRN3NCVkeHUh?=
BFTC-909 NY\GTWhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;Vd21rUUN3ME2zMlcyKG6P MoniV2FPT0WU
BPH-1 M2OxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnyWmxKSzVyPUSuO|Yhdk1? MnvOV2FPT0WU
PC-3 M1HEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHITWM2OD13LkC5JI5O M1XJb3NCVkeHUh?=
AN3-CA MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XrSmlEPTB;NT61OkBvVQ>? NGPubllUSU6JRWK=
HN MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHQZm5TUUN3ME21Mlk3KG6P M4DTTXNCVkeHUh?=
HCC2218 M3;iXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;WSY5KSzVyPU[uOlEhdk1? MlO3V2FPT0WU
KP-4 NULpe2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X5V2lEPTB;NzDuUS=> NEfGSoVUSU6JRWK=
LU-139 NXfK[4ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDTcVlKSzVyPUeuO|chdk1? NYXqepNZW0GQR1XS
ETK-1 NVHRT3ZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\BZnhNUUN3ME23Mlg5KG6P MmDaV2FPT0WU
Ramos-2G6-4C10 M{f4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRThwNEmgcm0> MYnTRW5ITVJ?
MHH-PREB-1 M3\4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3PW2RKSzVyPUmuNVIhdk1? M3j3cnNCVkeHUh?=
DU-4475 NEf3c5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT2TWM2OD17LkS0JI5O M2O0V3NCVkeHUh?=
NCI-H1666 M4Wyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnBdIlLUUN3ME25MlcyKG6P MVjTRW5ITVJ?
CAMA-1 NVrROFRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[0cYFFUUN3ME25Mlghdk1? NVHGfVU6W0GQR1XS
TYK-nu M3PiSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rFSWlEPTB;OT65OEBvVQ>? NHLxNnRUSU6JRWK=
MFE-280 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn65TWM2OD17Lkm5JI5O MVPTRW5ITVJ?
A549 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFyLkG0JI5O M2\WOnNCVkeHUh?=
769-P NWfYRmZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHtWIFKSzVyPUGwMlQ1KG6P NHHOfoZUSU6JRWK=
L-363 Mo\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjNbnRKSzVyPUGwMlY6KG6P NUnQbmxPW0GQR1XS
ES8 M2jYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;OS2lEPTB;MUCuPUBvVQ>? MVHTRW5ITVJ?
PA-1 M2rLXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPLTWM2OD1zMT64NkBvVQ>? MWPTRW5ITVJ?
Mewo MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFzLkm5JI5O MWTTRW5ITVJ?
HSC-3 NHjOem1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELFVpZKSzVyPUGyMlIyKG6P NWmwPZhqW0GQR1XS
H4 NIC1RmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\CcYdKSzVyPUGyMlY4KG6P MlLEV2FPT0WU
BB65-RCC MnzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHXU21KSzVyPUGyMlczKG6P MUXTRW5ITVJ?
NCI-H1793 MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjGbmtKSzVyPUGyMlgzKG6P M372TXNCVkeHUh?=
KARPAS-45 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XncGlEPTB;MUOuOVEhdk1? NEnFUXRUSU6JRWK=
GCT NVPRW4F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHQTWM2OD1zMz62PEBvVQ>? NXHufnNGW0GQR1XS
EoL-1 M2jRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S3dGlEPTB;MUOuPVMhdk1? NYHj[odFW0GQR1XS
LB2241-RCC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7WPIRKSzVyPUG0MlAyKG6P MmH1V2FPT0WU
ES5 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H6VGlEPTB;MUSuO|Qhdk1? MlvvV2FPT0WU
LOXIMVI MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF2Lkm5JI5O M4r3XHNCVkeHUh?=
COR-L105 MkDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLuR|lKSzVyPUG1MlA1KG6P NGqxXHVUSU6JRWK=
P12-ICHIKAWA NF[xfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITuNJdKSzVyPUG1MlEhdk1? NGjhXWJUSU6JRWK=
CHL-1 M3XadWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HsUWlEPTB;MUWuOFUhdk1? NF;3fGxUSU6JRWK=
VMRC-RCZ NX7vOINIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTF3Lk[zJI5O Mnz2V2FPT0WU
HH MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXoPWZbUUN3ME2xOU44KG6P NHnB[3RUSU6JRWK=
NUGC-3 NHL5Z2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF4LkO0JI5O NHTpem9USU6JRWK=
EGI-1 M3LmRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\FTYhKSzVyPUG2MlQ{KG6P MlX1V2FPT0WU
OS-RC-2 NEPPUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnwTWM2OD1zNj60O{BvVQ>? M{\jVXNCVkeHUh?=
MOLT-16 MonuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;hcmlEPTB;MUeuNVUhdk1? NInwbGtUSU6JRWK=
NCI-H209 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEm2T|dKSzVyPUG3MlI6KG6P MWPTRW5ITVJ?
697 NHPr[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvycIJKSzVyPUG3MlQ{KG6P MlLsV2FPT0WU
D-56MG M3jzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTF5Lk[5JI5O M{fBdnNCVkeHUh?=
VA-ES-BJ NUTuZo1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L4NmlEPTB;MUeuPFMhdk1? M2nXPHNCVkeHUh?=
EW-16 M2fnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF6LkC0JI5O M4DyeHNCVkeHUh?=
HGC-27 NW\vSYpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDqV2FFUUN3ME2xPE4xPiCwTR?= NHWyb|FUSU6JRWK=
ES7 M2n5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j1bmlEPTB;MUiuNFkhdk1? NX\zUJBKW0GQR1XS
HuH-7 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\OTWM2OD1zOD60JI5O NIjiWXRUSU6JRWK=
BCPAP NIDHS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fwVWlEPTB;MUiuOlUhdk1? Mor5V2FPT0WU
SW1710 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTGTWM2OD1zOD63NkBvVQ>? NE\WTFFUSU6JRWK=
IST-MEL1 NUXDW3M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TWZWlEPTB;MUiuO|chdk1? NIjuWYtUSU6JRWK=
SF295 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnW1TWM2OD1zOD65N{BvVQ>? MVPTRW5ITVJ?
RPMI-7951 NY\SdZJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;JZ2lEPTB;MUmuNlghdk1? M1fVW3NCVkeHUh?=
SF126 M{jEZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[0S|EzUUN3ME2xPU41OSCwTR?= M2DVOXNCVkeHUh?=
GAMG M{DaOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHOfnZKSzVyPUG5MlQ5KG6P NWL5VGtoW0GQR1XS
KNS-81-FD MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF7LkW0JI5O M2DNOHNCVkeHUh?=
RT-112 NUXnRXNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF7Lk[2JI5O MXLTRW5ITVJ?
DEL NW\HdZJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJyLkS5JI5O Mk[3V2FPT0WU
CGTH-W-1 MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjWZoNCUUN3ME2yNE43OyCwTR?= NV74T|VIW0GQR1XS
HOS NWTiSXJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjmZphKSzVyPUKxMlA3KG6P MlHSV2FPT0WU
ES4 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjKT4ZKSzVyPUKxMlA5KG6P MnviV2FPT0WU
RXF393 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInpR21KSzVyPUKxMlQ2KG6P NEW2NXNUSU6JRWK=
NCI-H2030 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r2NGlEPTB;MkGuOVIhdk1? MWnTRW5ITVJ?
YH-13 MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn21TWM2OD1{MT64PEBvVQ>? M{\sVXNCVkeHUh?=
HT-1080 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFO2V5RKSzVyPUKxMlk{KG6P M{\uZXNCVkeHUh?=
NCI-SNU-1 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ITWM2OD1{MT65OUBvVQ>? MorLV2FPT0WU
G-402 NG[2bmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTJ{LkG2JI5O MVHTRW5ITVJ?
786-0 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn4fFhKSzVyPUKyMlI6KG6P MmXZV2FPT0WU
ME-180 NEnHOmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzSTWM2OD1{Mj60N{BvVQ>? NISzZphUSU6JRWK=
NB69 MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32zTWlEPTB;MkKuOVMhdk1? Mn7XV2FPT0WU
J-RT3-T3-5 MmLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ucFlKSzVyPUKyMlk3KG6P MX3TRW5ITVJ?
TGBC1TKB NXTEVIpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M362fmlEPTB;MkOuNFUhdk1? MkjaV2FPT0WU
SW780 M3K0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTJ|LkGzJI5O MWrTRW5ITVJ?
MG-63 M{TPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ|LkS1JI5O NULGbm1YW0GQR1XS
BV-173 M3TpcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j5Z2lEPTB;MkOuPFchdk1? NFq1T4RUSU6JRWK=
CAL-51 M{fMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnkTWM2OD1{Mz64PUBvVQ>? MWLTRW5ITVJ?
A375 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LlbWlEPTB;MkOuPVMhdk1? NInwWIxUSU6JRWK=
MEL-HO MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTJ2LkC0JI5O MUTTRW5ITVJ?
EFO-27 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfDNY9KSzVyPUK0MlM{KG6P NEH1W3ZUSU6JRWK=
Hs-578-T M1L3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTsN3BiUUN3ME2yOE42QCCwTR?= MkLBV2FPT0WU
NBsusSR M3fpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXzW|VKSzVyPUK0MlYhdk1? M4T1THNCVkeHUh?=
CTB-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJ2Lk[3JI5O MkLOV2FPT0WU
FTC-133 NH;PcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ3LkGgcm0> M4LqS3NCVkeHUh?=
MOLT-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m2fmlEPTB;MkWuNVIhdk1? MYDTRW5ITVJ?
HO-1-N-1 NYTtWJVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:0RmlEPTB;MkWuNVUhdk1? NVL1R|B4W0GQR1XS
ES3 M2nWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3LSGRGUUN3ME2yOU4zOiCwTR?= MUHTRW5ITVJ?
TI-73 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJ3LkK4JI5O M1rGUHNCVkeHUh?=
MPP-89 M{TzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfoTWM2OD1{NT6zNkBvVQ>? MkHCV2FPT0WU
KYSE-150 NX7zOYxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7xNpNKSzVyPUK1Mlg6KG6P MYfTRW5ITVJ?
LXF-289 NXTBWoxMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTYWFVNUUN3ME2yOk4xPCCwTR?= MXzTRW5ITVJ?
SK-LU-1 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\lXmtKSzVyPUK2MlE4KG6P M{\NbnNCVkeHUh?=
HOP-92 M133c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJ4LkS4JI5O NHfjTmFUSU6JRWK=
HuO9 M3PLZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnv4TWM2OD1{Nj63OkBvVQ>? NH76S2lUSU6JRWK=
SW962 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPjWndKSzVyPUK2Mlc3KG6P NGiwR|FUSU6JRWK=
RS4-11 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD2TWM2OD1{Nj65NUBvVQ>? NITBSGpUSU6JRWK=
NCI-H292 NULuVYxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLoTWM2OD1{NzDuUS=> MVvTRW5ITVJ?
DB MnvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLreHJSUUN3ME2yO{4{PiCwTR?= MXzTRW5ITVJ?
SW1088 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4n4VGlEPTB;MkiuNlkhdk1? NFrENnVUSU6JRWK=
A204 NVflbFBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT5XVlKSzVyPUK4MlQ4KG6P MWPTRW5ITVJ?
A3-KAW MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJ6Lk[0JI5O MVnTRW5ITVJ?
MV-4-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ6Lkegcm0> MWTTRW5ITVJ?
ES1 MmflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXmySYRDUUN3ME2yPE45PCCwTR?= NWDhZottW0GQR1XS
ONS-76 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJ7LkC1JI5O MXnTRW5ITVJ?
D-263MG NVnsZ4tET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ7LkO1JI5O NH3QeVFUSU6JRWK=
U-2-OS MoTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTTTWM2OD1{OT61JI5O MVzTRW5ITVJ?
T98G M1XrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;1fYR1UUN3ME2yPU45QCCwTR?= NGDudGdUSU6JRWK=
GI-ME-N MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17weWlEPTB;MkmuPVEhdk1? MlrIV2FPT0WU
BHT-101 NWLKXGlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\mR2hDUUN3ME2zNE4xPSCwTR?= MWrTRW5ITVJ?
NOS-1 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInGWo1KSzVyPUOwMlEzKG6P MWXTRW5ITVJ?
AsPC-1 M4nHTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYeyT5NmUUN3ME2zNE4zKG6P M4O0bXNCVkeHUh?=
QIMR-WIL MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzZT401UUN3ME2zNE43KG6P MY\TRW5ITVJ?
JVM-3 NFe2cHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;RTWM2OD1|MD64N{BvVQ>? NIrwNY1USU6JRWK=
KU-19-19 NFvGO4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm1XmhKSzVyPUOxMlE{KG6P NHSzZnNUSU6JRWK=
OVCAR-8 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HvemlEPTB;M{GuNlYhdk1? MlvyV2FPT0WU
BEN MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFznV3ZKSzVyPUOxMlY{KG6P M4eybnNCVkeHUh?=
BE-13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrsSYlKSzVyPUOxMlgzKG6P NUL0T4lHW0GQR1XS
EW-18 NI\0c|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX30fHF4UUN3ME2zNU45PiCwTR?= NUjqRVZWW0GQR1XS
ECC10 M1rhe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7UfWVpUUN3ME2zNU46PSCwTR?= MmTzV2FPT0WU
CTV-1 NVf1NodbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jrRmlEPTB;M{KuPFIhdk1? M1LGd3NCVkeHUh?=
COLO-800 NETwZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnDc2dYUUN3ME2zNk46OiCwTR?= NXv2eFVvW0GQR1XS
A2058 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrSTWM2OD1|Mz6yOUBvVQ>? MVvTRW5ITVJ?
VM-CUB-1 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrGTGZQUUN3ME2zN{41OyCwTR?= NECwVYNUSU6JRWK=
Ca9-22 NYrTWVJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnwN5FKSzVyPUOzMlU2KG6P NH3pN4FUSU6JRWK=
COLO-684 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljGTWM2OD1|Mz61PEBvVQ>? MXHTRW5ITVJ?
RPMI-8226 NFHzN|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIP1dm1KSzVyPUOzMlgzKG6P NFS4SHJUSU6JRWK=
SK-NEP-1 MoPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fXfGlEPTB;M{SuNVUhdk1? NIHzVHRUSU6JRWK=
Becker M1TQSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTN2LkKxJI5O NHPsWVRUSU6JRWK=
NCI-H28 NWjWSYtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPWXGpKSzVyPUO0MlQ1KG6P NHvzfY9USU6JRWK=
CAL-120 NYX2UIxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnDTWM2OD1|ND63NkBvVQ>? MkewV2FPT0WU
MDA-MB-157 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTN3LkSxJI5O M1PpSnNCVkeHUh?=
OVCAR-5 M1PhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTlc|dPUUN3ME2zOU41PyCwTR?= NWPEU4tCW0GQR1XS
LAMA-84 NV;0OHZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTNTWM2OD1|NT64O{BvVQ>? MVXTRW5ITVJ?
CAKI-1 M3jhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;TVpFKSzVyPUO2MlQ{KG6P MnfRV2FPT0WU
Daoy NH;2cHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInUeotKSzVyPUO2Mlchdk1? MWTTRW5ITVJ?
CAL-62 Mlq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfCTmlKSzVyPUO2Mlg3KG6P M1q3fXNCVkeHUh?=
8-MG-BA NXPLT4g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjYfZFjUUN3ME2zO{4zPSCwTR?= MWLTRW5ITVJ?
8505C MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fsZmlEPTB;M{euOVEhdk1? MVrTRW5ITVJ?
LNCaP-Clone-FGC Mo\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTN5LkW5JI5O NGO0VmFUSU6JRWK=
CAL-39 NXvYeIUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPMOI1[UUN3ME2zO{46KG6P NHyw[3lUSU6JRWK=
MN-60 NF\L[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u3dGlEPTB;M{euPVYhdk1? MlLnV2FPT0WU
RKO NIDHW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfGZpdKSzVyPUO4MlM{KG6P NXn3e2dPW0GQR1XS
U251 NVO3dmVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN6LkSzJI5O M3mxeHNCVkeHUh?=
SJSA-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPqTWM2OD1|OD61OEBvVQ>? Mmf3V2FPT0WU
CAL-12T M1f1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTN6Lk[gcm0> M3PsbnNCVkeHUh?=
HCC1419 Ml7jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTN6LkexJI5O NHrNepBUSU6JRWK=
CO-314 NHGxTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvTOGtKSzVyPUO4Mlc1KG6P NG\P[YtUSU6JRWK=
LB1047-RCC NU\l[I9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rLOGlEPTB;M{iuPFEhdk1? NY\KXXlRW0GQR1XS
A101D M1;FXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHsdZJKSzVyPUO4Mlk4KG6P NYrCRnM5W0GQR1XS
MDA-MB-175-VII MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XUSmlEPTB;M{muOVEhdk1? NIXU[lRUSU6JRWK=
MZ2-MEL NV3qNGtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LmVGlEPTB;M{muOlYhdk1? MXTTRW5ITVJ?
NB5 NIe1XG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXFTWM2OD12MD62OEBvVQ>? NWHjWIJ4W0GQR1XS
G-401 NX3Udo9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTRyLkiyJI5O MXTTRW5ITVJ?
HT MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjXOIxHUUN3ME20NU4xOiCwTR?= NV7BS|Z1W0GQR1XS
8305C NXPLWGxNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTRzLki3JI5O NFHTUWlUSU6JRWK=
BHY MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrzSmpjUUN3ME20Nk44OiCwTR?= MmHPV2FPT0WU
NTERA-S-cl-D1 MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{f4cWlEPTB;NEOgcm0> NYDYSZdVW0GQR1XS
T-24 NELMfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD1N2syUUN3ME20N{45OyCwTR?= MoX3V2FPT0WU
EPLC-272H MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTR2LkO5JI5O NU\rRlhbW0GQR1XS
PSN1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXDTIE1UUN3ME20OE41KG6P NInuU2pUSU6JRWK=
NCI-H2452 NEXmU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP6bHdKSzVyPUS0MlU5KG6P MXfTRW5ITVJ?
KS-1 M3zsVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR2Lk[2JI5O NHjpfmFUSU6JRWK=
HD-MY-Z NY\YNFI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUP1dZhGUUN3ME20OE46OiCwTR?= MmTJV2FPT0WU
KNS-62 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXQVoJUUUN3ME20OU4{QCCwTR?= M2rZ[HNCVkeHUh?=
NOMO-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\XSY9KSzVyPUS1Mlg4KG6P MY\TRW5ITVJ?
SK-HEP-1 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXW[WxYUUN3ME20Ok4xPCCwTR?= M3TQcnNCVkeHUh?=
IGR-1 NXLFeYM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHneWZKSzVyPUS2MlE{KG6P NXjNc4FJW0GQR1XS
KYSE-180 NFThUGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR4LkG3JI5O MX3TRW5ITVJ?
EW-22 Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTuTWM2OD12Nj6yJI5O MVzTRW5ITVJ?
NCI-H1355 Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1GwTWlEPTB;NE[uN|Qhdk1? MWDTRW5ITVJ?
DOHH-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofETWM2OD12Nj6zO{BvVQ>? NWD0b2VWW0GQR1XS
A4-Fuk NH\5ZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHezV3FKSzVyPUS2MlUzKG6P NWHOb2hEW0GQR1XS
PC-14 M37CWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PHZWlEPTB;NE[uOVchdk1? NE\j[W1USU6JRWK=
TE-5 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zNW2lEPTB;NE[uPFQhdk1? M3vxU3NCVkeHUh?=
LB996-RCC NUT0cJEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfFTWM2OD12Nz6xPUBvVQ>? M3XyV3NCVkeHUh?=
NCI-H1623 M3\2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXKfmhFUUN3ME20O{44PiCwTR?= MlW2V2FPT0WU
NCI-H1155 NX;VdplHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK5TWM2OD12OD6zNkBvVQ>? NH\XS4NUSU6JRWK=
LoVo MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPZbHZKSzVyPUS4MlQhdk1? NVTjc5BsW0GQR1XS
MCF7 MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnxXm5KSzVyPUS4MlU5KG6P NXnVbXpoW0GQR1XS
AGS MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXMT5JKSzVyPUS4Mlc4KG6P M2Ow[3NCVkeHUh?=
PFSK-1 M4Ht[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13jWmlEPTB;NEmuNFYhdk1? Mn23V2FPT0WU
22RV1 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHjTWM2OD12OT6wPUBvVQ>? MVHTRW5ITVJ?
COR-L23 NI\uWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTR7LkG2JI5O MljaV2FPT0WU
D-283MED M4CwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7BTWM2OD12OT62NUBvVQ>? NITQZYFUSU6JRWK=
SW982 NU[yPIdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XsRmlEPTB;NEmuPVEhdk1? NUK5WFJjW0GQR1XS
SW620 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPQSFRyUUN3ME21NE4{PiCwTR?= MYXTRW5ITVJ?
KYSE-140 NXjtRok4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XUTGlEPTB;NUCuOVUhdk1? MoLsV2FPT0WU
GCIY MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTuTWM2OD13MD62O{BvVQ>? NUP1d2prW0GQR1XS
MHH-ESS-1 MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTVzLkm1JI5O MU\TRW5ITVJ?
D-423MG NFrRfGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\ZOGlEPTB;NUKuNFghdk1? MVPTRW5ITVJ?
SF539 NFToemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\SOXdKSzVyPUWyMlM2KG6P M{DtbHNCVkeHUh?=
RPMI-2650 NHTpW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPj[JZKSzVyPUWyMlY6KG6P MlzxV2FPT0WU
GR-ST MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTV{Lki3JI5O NXKyV3VzW0GQR1XS
YKG-1 NIDoWJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml22TWM2OD13MzDuUS=> NH2xPGhUSU6JRWK=
SK-MES-1 MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTV|LkK2JI5O NFzuOWRUSU6JRWK=
HLE MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TxdWlEPTB;NUOuOFchdk1? NVj1c2o2W0GQR1XS
RVH-421 Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzzUYVKSzVyPUWzMlY4KG6P NXfVdGhqW0GQR1XS
C32 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;kTWM2OD13Mz64N{BvVQ>? NEO5To1USU6JRWK=
GB-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTV2LkKgcm0> NEi2fWNUSU6JRWK=
SNB75 NXjINFJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTV2LkK2JI5O NWSxO4RxW0GQR1XS
EM-2 NF:xfpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPOTWM2OD13ND60JI5O MmnQV2FPT0WU
RH-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLKVGxKSzVyPUW0Mlchdk1? M{jQ[nNCVkeHUh?=
NKM-1 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPOT49mUUN3ME21OE45OSCwTR?= NG\aZoNUSU6JRWK=
NCI-H2405 MoTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnOTWM2OD13ND64PEBvVQ>? MXLTRW5ITVJ?
KYSE-450 NIrvTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLPTWM2OD13NT6xOkBvVQ>? NYKwW5Z2W0GQR1XS
A704 NYPKSXlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTV3LkW5JI5O NXHOe29IW0GQR1XS
HAL-01 NX7YfVNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\kfnVKSzVyPUW1Mlg{KG6P MXnTRW5ITVJ?
TE-11 NF7rUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrQXpNvUUN3ME21OU46QSCwTR?= NWPXdmdNW0GQR1XS
DOK Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7sRXdKSzVyPUW2MlAzKG6P NHnCR|BUSU6JRWK=
KY821 NH7LNHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq3TWM2OD13Nj6yJI5O MlG3V2FPT0WU
KGN NGiw[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfSTWM2OD13Nj6zNkBvVQ>? M3HaWHNCVkeHUh?=
MC116 NFHXPZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7FUoN{UUN3ME21O{45KG6P MkK5V2FPT0WU
PANC-08-13 M3zZ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zke2lEPTB;NUiuNFEhdk1? MnHkV2FPT0WU
KE-37 NEXvVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTV6Lke3JI5O NGLHfWtUSU6JRWK=
KYSE-410 NGHWS3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjlW45OUUN3ME21PU41PyCwTR?= NEf2bWJUSU6JRWK=
RO82-W-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1KybmlEPTB;NUmuPUBvVQ>? Mo[2V2FPT0WU
M14 MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PyfWlEPTB;NkCuNFQhdk1? M3u4XXNCVkeHUh?=
GI-1 M3\hPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLsTWM2OD14MD6zJI5O M{LRd3NCVkeHUh?=
ML-2 MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofaTWM2OD14MD62NkBvVQ>? M2\KVXNCVkeHUh?=
BFTC-905 M4\2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTZyLk[1JI5O NXjHVGVXW0GQR1XS
DMS-273 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTZyLki3JI5O NHfMemZUSU6JRWK=
MDA-MB-361 M37BeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vaXWlEPTB;NkGgcm0> NGDYXZZUSU6JRWK=
MSTO-211H NVn3PIkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLWdnRnUUN3ME22N{42OSCwTR?= NXzmOGpiW0GQR1XS
MEG-01 NETucWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xxe2lEPTB;NkOuOVIhdk1? M{TGXHNCVkeHUh?=
M059J M{XQSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTZ|LkW4JI5O MX\TRW5ITVJ?
LN-405 NXuxOplYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTZ|Lki1JI5O NILnUFhUSU6JRWK=
NCI-H1581 M3;tcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLWfpBKUUN3ME22OE4xOyCwTR?= NHnSU2RUSU6JRWK=
TCCSUP NYOxfVB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljoTWM2OD14ND61N{BvVQ>? M1fsbHNCVkeHUh?=
SW872 NIDhN2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZ2LkW3JI5O MX;TRW5ITVJ?
KYSE-510 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K2NWlEPTB;NkWuO|Uhdk1? NX\2Z5BlW0GQR1XS
NCI-H1792 NXPjS|dxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTZ4LkG1JI5O M{i0XXNCVkeHUh?=
SW13 NIjHcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jkT2lEPTB;Nk[uOUBvVQ>? M17HXnNCVkeHUh?=
TE-8 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\jR2tKSzVyPU[2MlUzKG6P M3nuNHNCVkeHUh?=
SCH MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGS0b4hKSzVyPU[3MlEhdk1? M3XPR3NCVkeHUh?=
NEC8 M4Tob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3sTWM2OD14Nz6yOEBvVQ>? NXLrV3J[W0GQR1XS
HuO-3N1 NGX5NXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\OcWlEPTB;NkeuN|Ehdk1? NIrBSGxUSU6JRWK=
EFM-19 M3v6bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;WTWM2OD14Nz61JI5O M{\ZSnNCVkeHUh?=
HEC-1 NFPqPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHPdFdKSzVyPU[3MlUzKG6P NIP1W|VUSU6JRWK=
T47D NUH6cYdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTmc5lKSzVyPU[3Mlg4KG6P MWLTRW5ITVJ?
SNU-423 M4LJVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHKZlc{UUN3ME22O{46QCCwTR?= NIjoWVhUSU6JRWK=
WM-115 M{njPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTZ6LkG0JI5O MYXTRW5ITVJ?
CaR-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7BWHJKSzVyPU[4MlI2KG6P MUTTRW5ITVJ?
KU812 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknWTWM2OD14OD62PUBvVQ>? NEPFd2hUSU6JRWK=
AM-38 NVfW[XdqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnKPGpKSzVyPU[5MlMyKG6P MYLTRW5ITVJ?
KOSC-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTZ7Lkm3JI5O NYDQU4Y4W0GQR1XS
MC-IXC M2LIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7ETWM2OD15MD6wPEBvVQ>? NETFe5RUSU6JRWK=
SCC-4 NIDwNHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTZNIFKSzVyPUexMlM5KG6P MYnTRW5ITVJ?
Calu-3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPWVVdHUUN3ME23NU46QCCwTR?= Mn\aV2FPT0WU
RPMI-8866 M3m5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTd{LkiyJI5O NGjieW9USU6JRWK=
OVCAR-4 NXXYZZNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7ZTWM2OD15Mz6zOkBvVQ>? M1rrbXNCVkeHUh?=
OAW-42 NXToXWRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\EcXdKSzVyPUezMlM6KG6P MlXVV2FPT0WU
ATN-1 NWfwbItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknDTWM2OD15Mz64O{BvVQ>? NXTPeYRlW0GQR1XS
CHP-212 M4TOZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLkTWM2OD15ND65OUBvVQ>? MXPTRW5ITVJ?
C2BBe1 M{i2SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTd3LkCzJI5O NXyzbZpxW0GQR1XS
A498 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPSTWM2OD15NT6xOUBvVQ>? NUfjW3hzW0GQR1XS
SH-4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqwTWM2OD15NT6yNUBvVQ>? NFnXWIdUSU6JRWK=
SNU-449 NUnXW4JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTd3Lke5JI5O NGTO[pBUSU6JRWK=
RD NWPKcFRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlftTWM2OD15NT64OkBvVQ>? NETCNG1USU6JRWK=
PANC-03-27 NFXWfppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[2SYo2UUN3ME23Ok4zPSCwTR?= Mn3OV2FPT0WU
S-117 NYTCS3o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\PNWdKSzVyPUe2MlI4KG6P MXvTRW5ITVJ?
SK-MEL-2 MmThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTSTWM2OD15Nj63OUBvVQ>? M3nafHNCVkeHUh?=
LK-2 MkDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L6ZmlEPTB;N{euNFUhdk1? NV3KW2d4W0GQR1XS
CP50-MEL-B MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLxcJpGUUN3ME23O{41KG6P NGq2NVZUSU6JRWK=
647-V NGHYTnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvUfoc2UUN3ME23PE4xPyCwTR?= NY\ZfJVbW0GQR1XS
LU-134-A MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M373cWlEPTB;N{muNFMhdk1? NHTucZZUSU6JRWK=
5637 M4D3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTsO4M{UUN3ME23PU4zOyCwTR?= MXjTRW5ITVJ?
NCI-H1437 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr0d|NNUUN3ME24NE42KG6P NFHaU3JUSU6JRWK=
NCI-H460 MoPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDnTWM2OD16MT6yN{BvVQ>? NUHWNJB3W0GQR1XS
BxPC-3 MliwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PFOWlEPTB;OEGuOFYhdk1? NILzepBUSU6JRWK=
CAN Mlf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVeyVXNRUUN3ME24NU45PCCwTR?= MofyV2FPT0WU
KINGS-1 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPXPG1KSzVyPUiyMlMzKG6P Mn65V2FPT0WU
OCUB-M NXviR|Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3npN2lEPTB;OEKuOFEhdk1? Mmi2V2FPT0WU
KALS-1 M{e2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjNdWJKSzVyPUiyMlU1KG6P NWjMWWNSW0GQR1XS
OCI-AML2 NX\WVZJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnRRVlKSzVyPUiyMlYyKG6P NXvHblVrW0GQR1XS
A253 NH73Z|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[xb|ZJUUN3ME24Nk43PSCwTR?= MXjTRW5ITVJ?
LCLC-97TM1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTh{Lki2JI5O Ml\4V2FPT0WU
NCI-H520 M4\HeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXIdnlKSzVyPUizMlA3KG6P NYm1Z|ZWW0GQR1XS
P30-OHK NXfFfmZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW1TWM2OD16Mz61JI5O NHK4fFRUSU6JRWK=
SBC-5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPMTWM2OD16Mz61NkBvVQ>? NXXrPGZuW0GQR1XS
HCE-T NXzxN2pyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTh|Lke0JI5O NFrwVZJUSU6JRWK=
JEG-3 NXzPc|JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XX[2lEPTB;OESuNUBvVQ>? NGnnNY9USU6JRWK=
KG-1 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP1VVJKSzVyPUi0MlI1KG6P NVXFZWRDW0GQR1XS
MIA-PaCa-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLZ[XExUUN3ME24OE42PCCwTR?= MmniV2FPT0WU
CAL-33 NYLKOZpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTh3LkC4JI5O NFjWNpNUSU6JRWK=
639-V NV;XdHprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTh3LkSyJI5O MUPTRW5ITVJ?
NCI-H1048 NIrTSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTh4LkOxJI5O MnTGV2FPT0WU
NCI-H1573 NX;5b25KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzvTWM2OD16Nz60PEBvVQ>? Mn7YV2FPT0WU
NCI-H2228 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Swd2lEPTB;OEiuNlYhdk1? NUTKU2NbW0GQR1XS
NB14 NHjE[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X6XmlEPTB;OEiuN{BvVQ>? MWfTRW5ITVJ?
SCC-25 NHizR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu3dWRKSzVyPUi5MlgzKG6P NYLqbYlPW0GQR1XS
A431 Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITwWGdKSzVyPUi5Mlk4KG6P NGqzVVJUSU6JRWK=
SN12C MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTlyLk[yJI5O Mor6V2FPT0WU
HuCCT1 NFvxW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTBTWM2OD17MD63OkBvVQ>? NFnaNmNUSU6JRWK=
LS-123 NFvGV|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6yTWM2OD17Mj6xPEBvVQ>? MomzV2FPT0WU
CAL-85-1 NHHm[o9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPRd41KSzVyPUmyMlQ5KG6P NHX0[nVUSU6JRWK=
ES6 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXSPY5KSzVyPUmyMlg{KG6P Mle3V2FPT0WU
NCI-H650 NIDiO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTl2LkC5JI5O NGW0UGRUSU6JRWK=
NCI-H446 NET1SY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTl3LkGyJI5O M{\pUnNCVkeHUh?=
EW-13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTl3Lke1JI5O Ml;QV2FPT0WU
HSC-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmyTWM2OD17NT64PUBvVQ>? NVHheFNGW0GQR1XS
U031 Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\wTWM2OD17Nj63N{BvVQ>? M1;Lb3NCVkeHUh?=
EW-11 M2XUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTl4Lki4JI5O M2PmenNCVkeHUh?=
GAK MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfQNWdOUUN3ME25PE46OyCwTR?= M{XQXXNCVkeHUh?=
SK-OV-3 M2Hifmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrXWWZCUUN3ME2xNFAvODdibl2= NH;ZWWpUSU6JRWK=
OMC-1 NYHscW44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PUeWlEPTB;MUCwMlE5KG6P NGrnUmdUSU6JRWK=
TK10 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\YfWlEPTB;MUCwMlIyKG6P M4TTR3NCVkeHUh?=
EKVX MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofMTWM2OD1zMECuOkBvVQ>? NFjZWFRUSU6JRWK=
Detroit562 MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moi2TWM2OD1zMEKuNVchdk1? MXfTRW5ITVJ?
SF268 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFyMj6zOEBvVQ>? M2\KN3NCVkeHUh?=
SNU-387 NUXleVM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\nVIlKUUN3ME2xNFQvOTdibl2= M{TkT3NCVkeHUh?=
MDA-MB-231 MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTFyNT6wOkBvVQ>? MnPpV2FPT0WU
NCI-H1563 M2L0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFyNT6xPEBvVQ>? NFTnRWVUSU6JRWK=
D-502MG M33YeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\WRnJpUUN3ME2xNFUvPyCwTR?= NHyzfpdUSU6JRWK=
A2780 NWLofoNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjDRod[UUN3ME2xNFYvPDdibl2= M{O2RXNCVkeHUh?=
IA-LM MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u0cWlEPTB;MUC3MlUyKG6P NEO2W3dUSU6JRWK=
D-392MG MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4D1VmlEPTB;MUC3MlU1KG6P NIrBOVRUSU6JRWK=
MS-1 NYDUNGIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\KTWM2OD1zMEeuO|Ehdk1? MXnTRW5ITVJ?
SW1990 M4SxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17wZ2lEPTB;MUC4MlU1KG6P MkT6V2FPT0WU
HEL MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLUTWM2OD1zMEmuNlkhdk1? MmXNV2FPT0WU
SW1573 NHPRSGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PiemlEPTB;MUC5MlMyKG6P MmrCV2FPT0WU
SW1783 NHXvUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjMfnpvUUN3ME2xNVAvOjJibl2= M1TITnNCVkeHUh?=
COLO-680N MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv4OoNKSzVyPUGxNE44PiCwTR?= MWLTRW5ITVJ?
NCI-N87 M3W2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFzMT6wOEBvVQ>? M{XzeXNCVkeHUh?=
SK-MEL-28 M325eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFzMT61OUBvVQ>? MXTTRW5ITVJ?
BT-20 NXjvXlNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz3TWM2OD1zMUKuNFEhdk1? M1\MVXNCVkeHUh?=
NCI-H1648 MnfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrqXm0yUUN3ME2xNVMhdk1? MojyV2FPT0WU
no-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnWTWM2OD1zMUOuNlghdk1? MmHCV2FPT0WU
MOLT-13 NV;HRW5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33acmlEPTB;MUGzMlQ1KG6P NX3BO25HW0GQR1XS
NCI-H2170 MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrl[npKSzVyPUGxOE42OSCwTR?= M2\qOHNCVkeHUh?=
HTC-C3 NHfDSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTFzNj64OUBvVQ>? MmPzV2FPT0WU
LU-99A Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37BPWlEPTB;MUG3MlIyKG6P MkW4V2FPT0WU
HCC2998 MkfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PlbGlEPTB;MUG3MlkzKG6P MljrV2FPT0WU
NB13 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m3dmlEPTB;MUG3Mlk6KG6P MnviV2FPT0WU
GT3TKB Ml\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7hd2hKSzVyPUGxPE4xQCCwTR?= MkLFV2FPT0WU
BT-549 M17rUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v5WmlEPTB;MUG4Mlk2KG6P NH;0U|BUSU6JRWK=
NCI-H747 NF7vSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFzOT6zOEBvVQ>? MVnTRW5ITVJ?
EW-1 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF{MD6yJI5O MkK4V2FPT0WU
LB831-BLC MlnqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPDTWM2OD1zMkCuOlMhdk1? NXvNellbW0GQR1XS
NMC-G1 NUDQVnRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvneGRKSzVyPUGyNU4yOSCwTR?= MVLTRW5ITVJ?
COLO-679 MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXxTWM2OD1zMkKuNVUhdk1? MlLzV2FPT0WU
HL-60 NYnIfo96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq3SY9FUUN3ME2xNlMvOSCwTR?= NE\OcYhUSU6JRWK=
MKN7 M{jpdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LLTWlEPTB;MUKzMlg{KG6P M{fqc3NCVkeHUh?=
RERF-LC-MS NWnaNXljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfLZ4R3UUN3ME2xNlQvOzFibl2= M2TRcnNCVkeHUh?=
DMS-114 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TPfGlEPTB;MUK1MlA6KG6P MlnLV2FPT0WU
HuP-T4 MoTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF{Nj65O{BvVQ>? Mle0V2FPT0WU
HCC2157 NGjIUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLMclVKSzVyPUGyO{42KG6P MVHTRW5ITVJ?
SKG-IIIa MmP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofNTWM2OD1zMkiuPEBvVQ>? M2\nXHNCVkeHUh?=
HCT-116 NUPzeFBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWixVY45UUN3ME2xN|AvPjRibl2= MljxV2FPT0WU
BB30-HNC NWD2fWlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe2R2ZKSzVyPUGzNE44QCCwTR?= M3HBXXNCVkeHUh?=
KYSE-270 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWKzVmJqUUN3ME2xN|AvQDhibl2= NV63SFZUW0GQR1XS
MFM-223 NXLTfId7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW2TWM2OD1zM{GuOVEhdk1? NWq3eZhLW0GQR1XS
NH-12 M4W2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjy[YdKSzVyPUGzNk46QSCwTR?= NGj3bItUSU6JRWK=
U-118-MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvTZ5hKSzVyPUGzN{43OiCwTR?= NYe2[VIxW0GQR1XS
ESS-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K4XGlEPTB;MUO1MlE5KG6P MmPNV2FPT0WU
D-247MG MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonjTWM2OD1zM{WuNlEhdk1? Mk\pV2FPT0WU
IGROV-1 M2XKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7OTWM2OD1zM{WuO|Yhdk1? MUXTRW5ITVJ?
C-33-A NFLDV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTF|NT65O{BvVQ>? M2W0dXNCVkeHUh?=
NCI-H1693 NX3sNoQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TETGlEPTB;MUO2MlEzKG6P NXvpd|hjW0GQR1XS
MLMA M{XPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTF|Nj61PEBvVQ>? NWDGVnUxW0GQR1XS
SK-N-AS M{jxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTF|Nz6xO{BvVQ>? Mo\iV2FPT0WU
NCI-H1755 M4rIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHKfoRxUUN3ME2xN|gvQDVibl2= M1PkTnNCVkeHUh?=
CHP-134 NHjoSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jpOGlEPTB;MUO5MlU2KG6P M2nLUHNCVkeHUh?=
LS-513 NW\HOW1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\lTWM2OD1zNECuPVEheE1? MmDIV2FPT0WU
TE-12 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULKdmpSUUN3ME2xOFAvQTNibl2= MVHTRW5ITVJ?
KNS-42 MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LkUWlEPTB;MUS0MlMhdk1? MmrnV2FPT0WU
SJRH30 NEnqNGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfT[3pKSzVyPUG0OE41PCCwTR?= M2DFTXNCVkeHUh?=
NCI-H1092 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHJcY5KSzVyPUG0OE42OiCwTR?= M3X2eXNCVkeHUh?=
H-EMC-SS NHWxOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjoTWM2OD1zNE[uPFEhdk1? NUjWVnpQW0GQR1XS
SK-MEL-3 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF2Nz61OUBvVQ>? NYq5NYVXW0GQR1XS
SK-N-FI NF7pc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF2Nz61PUBvVQ>? NWSzc4RyW0GQR1XS
NCI-H2126 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLxTWM2OD1zNEiuNVUhdk1? M3rkNnNCVkeHUh?=
NCI-H1299 M170fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO5VnlVUUN3ME2xOVAvOjJibl2= Mn7sV2FPT0WU
CFPAC-1 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL2[ZJKSzVyPUG1NE43PiCwTR?= MYDTRW5ITVJ?
NCI-H661 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTETWM2OD1zNUGuNlYhdk1? M{HtOXNCVkeHUh?=
KYSE-70 NUPVfVdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnuTWM2OD1zNUGuO|khdk1? MVvTRW5ITVJ?
SW900 M4\Gbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTF3ND62OUBvVQ>? NIrSVpNUSU6JRWK=
Ca-Ski MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTF3Nj6zPUBvVQ>? M4TGOHNCVkeHUh?=
HPAF-II MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnpWIZ7UUN3ME2xOVYvPDdibl2= MlzqV2FPT0WU
LB2518-MEL MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPLPGhKSzVyPUG1O{4yKG6P MkPwV2FPT0WU
LC-2-ad MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1ryPWlEPTB;MUW4MlYzKG6P NG[4UFNUSU6JRWK=
HCC1806 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fXPWlEPTB;MU[3Mlg5KG6P MVLTRW5ITVJ?
UACC-62 NFXzRWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXhWmNKSzVyPUG2PE4xQSCwTR?= NUXNWGRoW0GQR1XS
KM-H2 M2XPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i4TGlEPTB;MUewMlU5KG6P MVHTRW5ITVJ?
NCI-H2347 M1jrb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrzXo5KSzVyPUG3Nk44OiCwTR?= MY\TRW5ITVJ?
SCC-15 NF\j[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTF5Mz62OkBvVQ>? MnzXV2FPT0WU
BB49-HNC Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV31UmMyUUN3ME2xO|MvQDFibl2= MYfTRW5ITVJ?
GMS-10 M3\vW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nPcmlEPTB;MUezMlk1KG6P Mk[wV2FPT0WU
NCI-H2052 M3TLNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKx[GlKSzVyPUG3OE46KG6P NF7idItUSU6JRWK=
SW626 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrhTWM2OD1zN{[uNFYhdk1? M{XnSnNCVkeHUh?=
MDA-MB-415 NFO2OFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjhTWM2OD1zN{[uOlEhdk1? NGrEOVhUSU6JRWK=
Saos-2 NFHwPG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\yTWM2OD1zN{muN|Uhdk1? MVHTRW5ITVJ?
DK-MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv4[2E3UUN3ME2xPFAvOyCwTR?= M1vyTnNCVkeHUh?=
SNU-C2B MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\JTWM2OD1zOECuO|Mhdk1? NGXkfYhUSU6JRWK=
A427 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF6Mj61O{BvVQ>? M4rKPXNCVkeHUh?=
KP-N-YS MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;CW4pKSzVyPUG4OUBvVQ>? M2rSc3NCVkeHUh?=
J82 NXvTfWU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vXU2lEPTB;MUi1MlE5KG6P M3zs[HNCVkeHUh?=
LS-411N M3XoTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnXS|Q2UUN3ME2xPFcvOjhibl2= MVHTRW5ITVJ?
HCC1937 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF6Nz60PUBvVQ>? MYPTRW5ITVJ?
OE33 NVzMUJpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz0TWM2OD1zOEiuPVchdk1? NYmxSHlZW0GQR1XS
NB7 Mn31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnKNGdHUUN3ME2xPFkvQDlibl2= MWfTRW5ITVJ?
SW684 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3G1eWlEPTB;MUm2MlE{KG6P MVvTRW5ITVJ?
HT-144 M1Xl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF7Nj6xOUBvVQ>? NFjBNoxUSU6JRWK=
SK-MEL-30 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvqZ5dKSzVyPUG5Ok4zKG6P MljsV2FPT0WU
DBTRG-05MG NV3USmtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILvS41KSzVyPUG5PE41PyCwTR?= NEe5SYJUSU6JRWK=
NCI-H1395 NWftN2JXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\mVHdKSzVyPUG5PE45PSCwTR?= MmnjV2FPT0WU
NCI-H2122 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXrTWM2OD1{MECuOVkhdk1? MXTTRW5ITVJ?
no-10 M2L1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zTV2lEPTB;MkCxMlA1KG6P MYjTRW5ITVJ?
SW48 M2T2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M132TmlEPTB;MkCxMlMyKG6P M4DkOnNCVkeHUh?=
NCI-H1650 M1rG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13rUGlEPTB;MkC0MlAyKG6P M{fTc3NCVkeHUh?=
MZ1-PC NUPGNZZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrUUmVKSzVyPUKwOU42QCCwTR?= Mmm2V2FPT0WU
U-266 NGniWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzX[FN2UUN3ME2yNFUvPzlibl2= NGTLTW5USU6JRWK=
CAS-1 NHHkcHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJyNz60OEBvVQ>? NE\Ec4ZUSU6JRWK=
AU565 NX3n[lI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTKUo1KSzVyPUKxNk45OiCwTR?= Mnv3V2FPT0WU
UACC-257 NEC5R4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HSfmlEPTB;MkGzMlk6KG6P NGPHfY9USU6JRWK=
CAL-27 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fkU2lEPTB;MkG3MlA2KG6P Mm\QV2FPT0WU
NCI-H23 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TmdGlEPTB;MkG5MlM{KG6P NGm5T2lUSU6JRWK=
TE-6 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jMV2lEPTB;MkG5MlY5KG6P MVTTRW5ITVJ?
TGBC24TKB MoCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S3SGlEPTB;MkKyMlE4KG6P MUjTRW5ITVJ?
TE-1 NED1SmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m3RWlEPTB;MkKyMlg5KG6P MnPzV2FPT0WU
RCC10RGB M4jl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjBU2FZUUN3ME2yNlQvOTlibl2= M13wfnNCVkeHUh?=
NCI-H596 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXyTG1sUUN3ME2yNlgvOjJibl2= NVPhbW54W0GQR1XS
SW954 NHLvTXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLvemVZUUN3ME2yN|MvQDNibl2= NFj0WHJUSU6JRWK=
NCI-H2087 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjrTWM2OD1{M{SuOVEhdk1? NYfiOm94W0GQR1XS
SK-PN-DW MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4izcmlEPTB;MkO1MlE6KG6P M{fUenNCVkeHUh?=
KM12 NGL2bldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDpcYR4UUN3ME2yN|UvPyCwTR?= M3HseHNCVkeHUh?=
BT-474 M3nHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjRVnNKSzVyPUKzOU44OyCwTR?= MWfTRW5ITVJ?
IST-MES1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJ|Nj61O{BvVQ>? NI\0[49USU6JRWK=
HT-1197 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDUTWM2OD1{M{iuNFkhdk1? M4eweHNCVkeHUh?=
CAL-54 NYfJ[lM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrXXWN{UUN3ME2yN|gvPDlibl2= MUPTRW5ITVJ?
NB10 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXXV4ZKSzVyPUK0NE4xPiCwTR?= NEft[WVUSU6JRWK=
PANC-10-05 NFvYVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ2NT61OkBvVQ>? M1u0SXNCVkeHUh?=
NCI-H522 NX\XXo5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITYVJNKSzVyPUK0PE4{OSCwTR?= MmPlV2FPT0WU
A388 M4DSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELZbJBKSzVyPUK0PU45OiCwTR?= MUfTRW5ITVJ?
GOTO NW[x[lNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULFPWhUUUN3ME2yOVAvOjlibl2= NEfJcY9USU6JRWK=
KLE M1jwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm3R3EyUUN3ME2yOVEvQDdibl2= MVvTRW5ITVJ?
KYSE-520 NF65boZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq1bYNCUUN3ME2yOVIvQDZibl2= MWXTRW5ITVJ?
HCE-4 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjFbpJVUUN3ME2yOlIvPSCwTR?= M1z6fHNCVkeHUh?=
KURAMOCHI NGnIT|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13lOGlEPTB;Mk[1Mlkhdk1? Mmi2V2FPT0WU
HCC38 NHLxSXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvVTIZKSzVyPUK2Ok41QCCwTR?= M3jkWHNCVkeHUh?=
FADU NY\WTVhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:wTWM2OD1{Nk[uOlMhdk1? MYTTRW5ITVJ?
CW-2 M3X4NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJ4OT65OkBvVQ>? MkHVV2FPT0WU
L-428 NFLafIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn1RXdKSzVyPUK3OU4yPSCwTR?= MoT4V2FPT0WU
HCC1569 NH31VG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG3TWM2OD1{N{WuPFQhdk1? MYjTRW5ITVJ?
NCI-H810 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHMenFKSzVyPUK3PE4{OSCwTR?= M1\yfHNCVkeHUh?=
LB771-HNC NV[2eGMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO2TWM2OD1{OEWuPFQhdk1? NEfIemJUSU6JRWK=
LCLC-103H M{PsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M165W2lEPTB;Mki1Mlk6KG6P NWDmTY05W0GQR1XS
EFO-21 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vpdmlEPTB;Mki3MlY5KG6P NFn0VHNUSU6JRWK=
CAL-72 MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XCZWlEPTB;MkmzMlE6KG6P MV\TRW5ITVJ?
SCC-9 M1q5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\FTWM2OD1{OUOuNlIhdk1? MXPTRW5ITVJ?
COLO-829 NVX1NZpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zyS2lEPTB;Mkm2MlUhdk1? NFHqWm9USU6JRWK=
U-87-MG M1HxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTNyMD63N{BvVQ>? NYThZll6W0GQR1XS
MZ7-mel MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfnTWM2OD1|MkOuO|Yhdk1? Ml3VV2FPT0WU
NCI-H1770 MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[xVmlEPTB;M{K2Mlc1KG6P NWmyXXVyW0GQR1XS
ChaGo-K-1 M4TW[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTN{OD6xJI5O NFvMVppUSU6JRWK=
SiHa NEmyT2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T1VWlEPTB;M{K5MlI1KG6P MXzTRW5ITVJ?
NCI-SNU-5 M1TUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN|Nj63O{BvVQ>? NXnxbYZzW0GQR1XS
DJM-1 M{POdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HHb2lEPTB;M{SwMlM{KG6P M4iwdnNCVkeHUh?=
OE19 NEL2c5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEWzV4FKSzVyPUO0NE42OyCwTR?= NEm0UHBUSU6JRWK=
NCI-H1651 NWXRUodUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XFfmlEPTB;M{S0MlE5KG6P M1:2fXNCVkeHUh?=
COLO-792 M3H0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN3ND60NkBvVQ>? M2X1bXNCVkeHUh?=
ACHN MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jteGlEPTB;M{W2MlcyKG6P MYTTRW5ITVJ?
TH-3 NFWxPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnoVpJKSzVyPUO3PU46PSCwTR?= NHrrV2VUSU6JRWK=
HT-1376 M{\qfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHQRmNsUUN3ME2zPFQvQDhibl2= NU\0cYtFW0GQR1XS
RH-18 NF;G[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPWWnVKSzVyPUO5OE44PCCwTR?= M{XWVHNCVkeHUh?=
NB6 NEnCOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfOXY1{UUN3ME2zPVYvPjZibl2= NWnubVY5W0GQR1XS
COLO-320-HSR NYfBSG56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLMTWM2OD12MEOuN|chdk1? MXnTRW5ITVJ?
UACC-893 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfp[Fl[UUN3ME20NFYvPDdibl2= M2jBR3NCVkeHUh?=
DSH1 M1\KXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofPTWM2OD12ME[uPVEhdk1? M1vte3NCVkeHUh?=
TE-10 M4X5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[3ZmlEPTB;NEC3MlAyKG6P MlL2V2FPT0WU
HCC70 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH2zbZpKSzVyPUSwPU4zOSCwTR?= MlP4V2FPT0WU
TGBC11TKB NWOwXGFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnkVHFKSzVyPUSxNE4{OyCwTR?= NHL0ZmFUSU6JRWK=
NCI-H727 MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjRNnFKSzVyPUSxNk4yOSCwTR?= MlzyV2FPT0WU
ALL-PO NXnyW2xmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXy1RWlHUUN3ME20NVUvPjlibl2= NVPado1[W0GQR1XS
ABC-1 Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\lfFMzUUN3ME20NlAvPDVibl2= MmTJV2FPT0WU
NCI-H69 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fRN2lEPTB;NEK2Mlc3KG6P MV3TRW5ITVJ?
GP5d MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfQUpBGUUN3ME20N|QvPDFibl2= MWPTRW5ITVJ?
UMC-11 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL0TWM2OD12NUiuN|Yhdk1? MWTTRW5ITVJ?
RMG-I MlyzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTR4Nz61OkBvVQ>? NUjzSIVxW0GQR1XS
YAPC NVqyU5lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTZV3BLUUN3ME20PVAvPiCwTR?= M4PsS3NCVkeHUh?=
LS-1034 M2rRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HRZmlEPTB;NEmxMlA3KG6P NVvuRpFQW0GQR1XS
RCM-1 NEDId3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkThTWM2OD12OU[uOlghdk1? Mn3zV2FPT0WU
HCC1954 NYfVdJR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTVzMj61JI5O NETEe3pUSU6JRWK=
SK-MEL-24 Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;PTWM2OD13MU[uOVEhdk1? MULTRW5ITVJ?
NB12 NIfGcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrrUnRxUUN3ME21NlgvPDJibl2= NVviOVd4W0GQR1XS
SW756 NHXMdHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTV3ND65OkBvVQ>? NXTyTYpwW0GQR1XS
HCC1187 NVrHXGtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnOzTWM2OD13N{WuPFMhdk1? MlHwV2FPT0WU
NCI-H2342 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\5ZmVKSzVyPUW5NE4{QSCwTR?= MnTDV2FPT0WU
NCI-H2291 NVHFW4JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzSTWM2OD13OUiuN|Ehdk1? MVvTRW5ITVJ?
OVCAR-3 NXTkXmZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3WTIZ2UUN3ME21PVgvQTZibl2= NUDlWphXW0GQR1XS
MHH-NB-11 NW\6d|lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP2TWRKSzVyPU[yPU4xOSCwTR?= NFfXdZlUSU6JRWK=
SAS NHrpfZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjpcpRKUUN3ME22OVIvPjdibl2= M2PuOXNCVkeHUh?=
COLO-824 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Hhd2lEPTB;Nki5MlM4KG6P NUSx[YRwW0GQR1XS
HCC1395 NY\DbWZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTZ7OD61JI5O NH;LNY5USU6JRWK=
COLO-668 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL3TWM2OD15ME[uNUBvVQ>? Mne3V2FPT0WU
NCI-H226 NXKye3FFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjUdnRKSzVyPUewO{45KG6P NYXtfnNuW0GQR1XS
NB17 NH[5ZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HuTmlEPTB;N{KxMlc2KG6P M2n6UnNCVkeHUh?=
SW1463 NXjDSohpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlj3TWM2OD15M{muNVkhdk1? Mnj3V2FPT0WU
TGW NFrOXXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3qRXJKSzVyPUe2NE4yPSCwTR?= MoDmV2FPT0WU
NCI-H526 NHzSeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml75TWM2OD16MkOuOVMhdk1? M1TtSHNCVkeHUh?=
COR-L88 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f6TWlEPTB;OES4MlEzKG6P MnnYV2FPT0WU
NCI-H441 MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTh7NT6yNkBvVQ>? NXvYbVFpW0GQR1XS
NCI-H630 NVq4S2o1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTlzMj65OkBvVQ>? MYPTRW5ITVJ?
Mo-T MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{e4S2lEPTB;OUS3Mlg5KG6P NXO4codrW0GQR1XS
JAR NHvjXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DhbWlEPTB;OUW2MlI1KG6P NVLu[oNRW0GQR1XS
NCI-H1838 NFjUblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2WzV2lEPTB;MT6wNlM5QCEQvF2= M1TRfHNCVkeHUh?=
DoTc2-4510 Mk\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTFwMEezO|Yh|ryP NF[4d4lUSU6JRWK=
MKN28 M2PPemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XaVWlEPTB;MT6wPVAzPCEQvF2= NE\VN2ZUSU6JRWK=
HuP-T3 M3uwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn5O4V{UUN3ME2xMlEyQTB3IN88US=> NXHwOWh[W0GQR1XS
TE-9 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFwMUK5O|Mh|ryP M3rpVnNCVkeHUh?=
NY MoH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWiwd5Z3UUN3ME2xMlE3Pzl{IN88US=> NV;5W3JsW0GQR1XS
HT55 M{LRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm5SVVJUUN3ME2xMlMyOzR2IN88US=> MljVV2FPT0WU
SW837 NV3VOHVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXGd3ZSUUN3ME2xMlMzQTd6IN88US=> M{S5S3NCVkeHUh?=
NCI-H2029 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjKUVlKSzVyPUGuOFE4QTFizszN MXzTRW5ITVJ?
IST-SL1 NFrnVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjRTWM2OD1zLkS0NlQh|ryP NYTEXZV5W0GQR1XS
COLO-741 M2XrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTFwNEm3O|Eh|ryP MXnTRW5ITVJ?
LU-65 NGXLUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUW3cXNvUUN3ME2xMlYzOjR7IN88US=> NEHwdYJUSU6JRWK=
NCI-H1304 M1vO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwNkW0PVgh|ryP M3fXPHNCVkeHUh?=
KARPAS-299 NIXMNZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTFwN{m0O|kh|ryP NHLJPJNUSU6JRWK=
NCI-H358 M2Cxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[1TIhDUUN3ME2xMlk2PTB|IN88US=> MXzTRW5ITVJ?
OAW-28 NEK1eZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fP[WlEPTB;Mj6wOlkyQSEQvF2= MmfxV2FPT0WU
C8166 NFi1PHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3sbXdKSzVyPUKuOlM{QTJizszN M{TjXHNCVkeHUh?=
COLO-678 M1LMVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjX[Y5xUUN3ME2yMlg{PzZ6IN88US=> NH;MdG5USU6JRWK=
SK-N-DZ NXznU4R5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJwOE[zPFEh|ryP NFPy[VVUSU6JRWK=
NCI-H82 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni5TWM2OD1{LkmwN|Y6KM7:TR?= MWnTRW5ITVJ?
JVM-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTNwMEOxPFgh|ryP NHvie2pUSU6JRWK=
SW1116 Mn:1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrwTWM2OD1|LkC1OFEyKM7:TR?= NWTXcWdrW0GQR1XS
MDA-MB-453 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDYZW9KSzVyPUOuNVA1OzlizszN MY\TRW5ITVJ?
Calu-6 M2\HWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHJTnBRUUN3ME2zMlE6QTdizszN M2C4R3NCVkeHUh?=
SHP-77 M1vCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTNwNUK4JO69VQ>? NUT1VVF6W0GQR1XS
Capan-2 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrjS2lKSzVyPUSuN|I2QDFizszN MXvTRW5ITVJ?
SW948 M2\vVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnDTG41UUN3ME20Mlc1Pzd7IN88US=> MYLTRW5ITVJ?
HDLM-2 M{PyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\GXnZKSzVyPUWuNFc4OjVizszN NWXWNXc6W0GQR1XS
LAN-6 NX76ZmtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTZwMkG0PVUh|ryP NWT2TlJnW0GQR1XS
LU-135 NFzndYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D0T2lEPTB;Nj60N|A4PyEQvF2= MUfTRW5ITVJ?
T84 MknOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TVTGlEPTB;Nj65PFY1KM7:TR?= MkmzV2FPT0WU
CAPAN-1 NV;afnZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XhZ2lEPTB;Nz62NlI{OyEQvF2= NFTCfWNUSU6JRWK=
SW1417 M{\0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTnZXZbUUN3ME23MlkyPzNzIN88US=> NWfrZXd[W0GQR1XS
BALL-1 M2[wNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj5TWM2OD16LkWwOFA6KM7:TR?= NXTCN4pTW0GQR1XS
HT-29 NYT3clB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTlwMEe1PVkh|ryP M{\xfHNCVkeHUh?=
C3A NY\rTZRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHBTWM2OD17Lki4N|k1KM7:TR?= MoGwV2FPT0WU
NCI-H1993 NYDqR4ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnhTWM2OD1zMD61NFgyKM7:TR?= NIfFW4RUSU6JRWK=
SK-MEL-1 NFnwfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfGTWM2OD1zMT62Nlg6KM7:TR?= MVHTRW5ITVJ?
DU-145 NHfLdVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDOTWM2OD1zND61NFUzKM7:TR?= M2PPeXNCVkeHUh?=
KP-N-YN MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPjbFFYUUN3ME2xOE42OTB|IN88US=> NVPvb|dwW0GQR1XS
CCRF-CEM M{\v[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jBUGlEPTB;MUSuO|gxQSEQvF2= Ml;QV2FPT0WU
ZR-75-30 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDUVWRKSzVyPUG2MlM{ODNizszN MYPTRW5ITVJ?
A673 MkPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrTSXpKSzVyPUKwMlU2ODdizszN MUfTRW5ITVJ?
K-562 NWLWWWZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV22WlduUUN3ME2yPE41OTh|IN88US=> NUX4TJBXW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+polyethylene glycol 300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products5

Tags: buy Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) supplier | purchase Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) cost | Dactolisib (BEZ235, NVP-BEZ235) manufacturer | order Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID