Dactolisib (BEZ235)

For research use only.

Catalog No.S1009 Synonyms: NVP-BEZ235

297 publications

Dactolisib (BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.

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Selleck's Dactolisib (BEZ235) has been cited by 297 publications

Purity & Quality Control

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Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei M4DRRmFvfGmvaXPyc4Jq[WxiQYPzZZk> NELzPHYyQCCq M3WxcGROW09? NGTxWFRCdnSrdIL5dIFvd3OxbXHsJIFkfGm4aYT5JJdqfGhiRVO1NEBw\iByLkCwNlUh|ryP MlriNlQ5ODV7NE[=
MCF7 M2\tNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;jNE4xOS1zMECg{txO NVXCNWlPPDhiaB?= MY\EUXNQ MVLJR|UxRTBwN{Og{txO NFi5TWwzOzh5MUmwOC=>
HCT116 NWrGRoZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPwNE4xOS1zMECg{txO NUHScVQ3PDhiaB?= NEPlUIxFVVOR M3LxdmlEPTB;MT6xOkDPxE1? MUWyN|g4OTlyNB?=
U87MG NVS4TW5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq1eWIxNjBzLUGwNEDPxE1? NE\DZ4s1QCCq M{XuVWROW09? M33ucGlEPTB;MT6zNkDPxE1? MnXqNlM5PzF7MES=
HBC4 Mk\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\sXFAvODFvMUCwJO69VQ>? NX;UTo1tPDhiaB?= M1zncWxw\yCJSUWwQU05NjZzIF2= M{n4d|IzOzN4MkS2
BSY1 M4jHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DqTlAvODFvMUCwJO69VQ>? Ml3sOFghcA>? MWLMc4chT0l3ME2tPE41QCCP Ml;NNlI{OzZ{NE[=
HBC5 NFzJfoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn1NE4xOS1zMECg{txO M3\WPVQ5KGh? NELSOpRNd2diR1m1NF0uPy56NzDN MXOyNlM{PjJ2Nh?=
MCF7 NWDne5hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13VPVAvODFvMUCwJO69VQ>? MWC0PEBp NXW2PVhIVG:pIFfJOVA:NThwMU[gUS=> MnTPNlI{OzZ{NE[=
MDA-MB-231 NX3aSGs3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUewMlAyNTFyMDFOwG0> MorlOFghcA>? MmPFUI9oKEeLNUC9MVgvODliTR?= MmfwNlI{OzZ{NE[=
U251 M4DqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXQe3IxNjBzLUGwNEDPxE1? MUG0PEBp NH[zcppNd2diR1m1NF0uPy54NjDN MUCyNlM{PjJ2Nh?=
SF268 NIDLZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\YR|AvODFvMUCwJO69VQ>? NF;vVI41QCCq MoLkUI9oKEeLNUC9MVcvQTJiTR?= NXXDOJYxOjJ|M{[yOFY>
SF295 M3\1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPWXHFUOC5yMT2xNFAh|ryP MVy0PEBp MmG0UI9oKEeLNUC9MVgvOzFiTR?= NW\mVZJVOjJ|M{[yOFY>
SF539 NFHucJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHyNE4xOS1zMECg{txO Mnz2OFghcA>? NELxXHlNd2diR1m1NF0uQC53OTDN NETwVI8zOjN|NkK0Oi=>
SNB75 NVTBR2dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[wUVAvODFvMUCwJO69VQ>? M{LCRVQ5KGh? M4jrXWxw\yCJSUWwQU05NjV6IF2= MlnaNlI{OzZ{NE[=
SNB78 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYiwMlAyNTFyMDFOwG0> NGD6[VM1QCCq MUDMc4chT0l3ME2tPE43PSCP NEXTcVUzOjN|NkK0Oi=>
HCC2998 NI\VSYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHniZ5IxNjBzLUGwNEDPxE1? MWG0PEBp MWHMc4chT0l3ME2tPE4xPSCP M4G5NlIzOzN4MkS2
KM12 NEG3VpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTDNE4xOS1zMECg{txO MkXBOFghcA>? NGHvVI5Nd2diR1m1NF0uPy53NDDN M4DQWVIzOzN4MkS2
HT-29 NGTlbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYKwMlAyNTFyMDFOwG0> M3vJ[|Q5KGh? M4TJZ2xw\yCJSUWwQU04Njd3IF2= MXmyNlM{PjJ2Nh?=
HCT15 NYTiVZB3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmwMlAyNTFyMDFOwG0> M4jNcVQ5KGh? NWrtOJp5VG:pIFfJOVA:NThwMEOgUS=> MnjBNlI{OzZ{NE[=
HCT116 Moi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnxNE4xOS1zMECg{txO NU\sbJl4PDhiaB?= NUK1N|RWVG:pIFfJOVA:NTdwNkGgUS=> NXfaTmxWOjJ|M{[yOFY>
NCI-H23 NILnR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfOWplYOC5yMT2xNFAh|ryP NV7tfGNmPDhiaB?= NV63Rmg4VG:pIFfJOVA:NTdwNkSgUS=> M1[4VFIzOzN4MkS2
NCI-H226 NFqzUGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPHOIcxNjBzLUGwNEDPxE1? M2W3e|Q5KGh? M17UPGxw\yCJSUWwQU05NjR2IF2= NVXuPJVuOjJ|M{[yOFY>
NCI-H522 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH2eIUxNjBzLUGwNEDPxE1? NVr6SJRvPDhiaB?= Mn;mUI9oKEeLNUC9MVgvPDViTR?= M3\ydVIzOzN4MkS2
NCI-H438 M4rkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m3dFAvODFvMUCwJO69VQ>? M2TVWVQ5KGh? M2LSZmxw\yCJSUWwQU05NjFzIF2= MkjRNlI{OzZ{NE[=
A549 NGXT[mVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HFdVAvODFvMUCwJO69VQ>? NXi0fHlkPDhiaB?= NHXvbHpNd2diR1m1NF0uQC5yNzDN MmrsNlI{OzZ{NE[=
DMS273 NX3pNmxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYCwMlAyNTFyMDFOwG0> NHnoT|I1QCCq MWfMc4chT0l3ME2tO{45OCCP MWmyNlM{PjJ2Nh?=
DMS114 Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrpNE4xOS1zMECg{txO NFjS[IM1QCCq MVPMc4chT0l3ME2tPE4{QSCP NWe4eXFuOjJ|M{[yOFY>
LOXIMVI MnPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDC[ngxNjBzLUGwNEDPxE1? NInBV4c1QCCq NG\WfWFNd2diR1m1NF0uQC54NjDN M1rCTVIzOzN4MkS2
OVCAR3 NUnhZoQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\ZV2wxNjBzLUGwNEDPxE1? M1TBRlQ5KGh? M4K4b2xw\yCJSUWwQU05NjF5IF2= NUPMdpF7OjJ|M{[yOFY>
OVCAR4 Mn7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfaRVlHOC5yMT2xNFAh|ryP M4PQT|Q5KGh? MonmUI9oKEeLNUC9MVgvPThiTR?= MoTGNlI{OzZ{NE[=
OVCAR5 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHCb|R7OC5yMT2xNFAh|ryP NVPXfFg4PDhiaB?= M1y1OWxw\yCJSUWwQU04NjV5IF2= NF21T28zOjN|NkK0Oi=>
OVCAR8 MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSwc4Q5OC5yMT2xNFAh|ryP NY\MTpNSPDhiaB?= MnjmUI9oKEeLNUC9MVcvQDRiTR?= MXmyNlM{PjJ2Nh?=
SKOV3 NGHxPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnToNE4xOS1zMECg{txO M2fn[lQ5KGh? NEHT[HpNd2diR1m1NF0uQC52MTDN MmLsNlI{OzZ{NE[=
RXF631L MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ftTVAvODFvMUCwJO69VQ>? NEW0UGc1QCCq MmP0UI9oKEeLNUC9MVgvOjFiTR?= Ml2wNlI{OzZ{NE[=
ACHN MnXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLsNE4xOS1zMECg{txO NFf6NI41QCCq NXHCOZA4VG:pIFfJOVA:NTdwOUWgUS=> M1XKO|IzOzN4MkS2
St-4 NYjaSJpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\BRWMxNjBzLUGwNEDPxE1? M36xO|Q5KGh? NV[wbphuVG:pIFfJOVA:NTdwNEegUS=> NEXP[lUzOjN|NkK0Oi=>
MKN1 MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUewMlAyNTFyMDFOwG0> M4C5S|Q5KGh? NWLEV482VG:pIFfJOVA:NThwNEGgUS=> MYeyNlM{PjJ2Nh?=
MKN7 NF[4NZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXKdHAxNjBzLUGwNEDPxE1? MkLaOFghcA>? M2nFdmxw\yCJSUWwQU04NjZ6IF2= NVTkWGNKOjJ|M{[yOFY>
MKN28 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnDNE4xOS1zMECg{txO MoDBOFghcA>? NWD3enRXVG:pIFfJOVA:NTdwMEegUS=> NXm4UIg3OjJ|M{[yOFY>
MKN45 MoLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWOwMlAyNTFyMDFOwG0> M1H1O|Q5KGh? MmHjUI9oKEeLNUC9MVgvOzRiTR?= M1HzSFIzOzN4MkS2
MKN74 M2TK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zkclAvODFvMUCwJO69VQ>? NXvUUnNEPDhiaB?= M4nhR2xw\yCJSUWwQU04NjR{IF2= M4LSNlIzOzN4MkS2
DU145 NX7rV|dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGwMlAyNTFyMDFOwG0> NHf6e4Q1QCCq MWrMc4chT0l3ME2tPE4yPiCP MlrJNlI{OzZ{NE[=
PC3 NETab3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M321flAvODFvMUCwJO69VQ>? M{Xr[|Q5KGh? M1rG[Gxw\yCJSUWwQU05NjZ4IF2= MX6yNlM{PjJ2Nh?=
Trypanosoma brucei brucei NIX1NWpHfW6ldHnvckBCe3OjeR?= NEW0eHczODBibl2= NG\wZVIyOiCq MWfEUXNQ MW\E[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt M3HIdFI1QDB3OUS2
Trypanosoma brucei brucei NWfnbmJZTnWwY4Tpc44hSXO|YYm= NYHsUIpmOThiaB?= MXfEUXNQ M3LMd2lvcGmkaYTpc44hd2ZicnXj[ZB1d3JvbXXkbYF1\WRiZX7kc4N6fG:|aYOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5idILhcpNn\XK{aX6geZB1[Wun M2\4O|I1QDB3OUS2
Trypanosoma brucei brucei NW[3UIxpTnWwY4Tpc44hSXO|YYm= NGOzR|EzODBibl2= MlHxNVIhcA>? NVy4botHTE2VTx?= NHjpT4tG\m[nY4Sgc44he3CqaX7nc416dGWrbjDs[ZZmdA>? NVW2NWZEOjR6MEW5OFY>
Trypanosoma brucei brucei NXz3RZU{TnWwY4Tpc44hSXO|YYm= NHXsbmQzODBibl2= NHqzXYcyOiCq NHHpcG5FVVOR M3rkUmVn\mWldDDvckBxcG:|cHjheIllgWylaH;sbY5mKGyndnXs NWi2TpIxOjR6MEW5OFY>
UM-UC-3 NUjZRWR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPCUXVsUUN3ME2zNVUheE1? NWXRfldMW0GQR1XS
SBC-1 MlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXqXpBIUUN3ME23OFIheE1? NYq1ZWl4W0GQR1XS
MKN1 MkTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfnTWM2OD1{Lkigcm0> MlHlV2FPT0WU
NCI-H720 M4jke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fPcGlEPTB;Mz61O{BvVQ>? NUnkXm06W0GQR1XS
BFTC-909 NFXuU5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;QV29KSzVyPUOuO|Ehdk1? Mn3oV2FPT0WU
BPH-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW3e3pKSzVyPUSuO|Yhdk1? NIfPT4FUSU6JRWK=
PC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nMN2lEPTB;NT6wPUBvVQ>? MlHWV2FPT0WU
AN3-CA NXnJOlZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPqTWM2OD13LkW2JI5O MlTYV2FPT0WU
HN MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHDblZKSzVyPUWuPVYhdk1? NGHUTmVUSU6JRWK=
HCC2218 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoiyTWM2OD14Lk[xJI5O MWrTRW5ITVJ?
KP-4 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDuTWM2OD15IH7N MXfTRW5ITVJ?
LU-139 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDlWZZKSzVyPUeuO|chdk1? MmLnV2FPT0WU
ETK-1 NI\tR3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zCOGlEPTB;Nz64PEBvVQ>? NILiWYZUSU6JRWK=
Ramos-2G6-4C10 NG\m[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnaR4JKSzVyPUiuOFkhdk1? M1TJ[XNCVkeHUh?=
MHH-PREB-1 NUW3d5VST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[xTWM2OD17LkGyJI5O MXHTRW5ITVJ?
DU-4475 NGTUXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37ESmlEPTB;OT60OEBvVQ>? MlzuV2FPT0WU
NCI-H1666 NWjTXnBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\TbHBqUUN3ME25MlcyKG6P MlfUV2FPT0WU
CAMA-1 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTlwODDuUS=> M2nRVXNCVkeHUh?=
TYK-nu M4rEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDCWlJRUUN3ME25Mlk1KG6P MYLTRW5ITVJ?
MFE-280 NVnkUGhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvDfYZtUUN3ME25Mlk6KG6P MkH5V2FPT0WU
A549 MkT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\CN2lEPTB;MUCuNVQhdk1? M37Yc3NCVkeHUh?=
769-P MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuxUWpKSzVyPUGwMlQ1KG6P NIjKT3ZUSU6JRWK=
L-363 MlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLUTWM2OD1zMD62PUBvVQ>? NWP3c3dOW0GQR1XS
ES8 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[1TWM2OD1zMD65JI5O MWTTRW5ITVJ?
PA-1 MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTPfFBOUUN3ME2xNU45OiCwTR?= MkDaV2FPT0WU
Mewo NYToZ3RjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XP[GlEPTB;MUGuPVkhdk1? NXHhR25zW0GQR1XS
HSC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjuTWM2OD1zMj6yNUBvVQ>? MWTTRW5ITVJ?
H4 NWTFW2gxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTQb3JKSzVyPUGyMlY4KG6P NV:wSWJ2W0GQR1XS
BB65-RCC MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjXTWM2OD1zMj63NkBvVQ>? MmDVV2FPT0WU
NCI-H1793 M2S2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXTeXpKSzVyPUGyMlgzKG6P MXrTRW5ITVJ?
KARPAS-45 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7ueW9oUUN3ME2xN{42OSCwTR?= MkTYV2FPT0WU
GCT NHHydFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfaVFFjUUN3ME2xN{43QCCwTR?= M2LDc3NCVkeHUh?=
EoL-1 Mke0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES1U5RKSzVyPUGzMlk{KG6P NVfrfYxNW0GQR1XS
LB2241-RCC MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDSWYhZUUN3ME2xOE4xOSCwTR?= MXfTRW5ITVJ?
ES5 MkLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn5TnlKSzVyPUG0Mlc1KG6P MUDTRW5ITVJ?
LOXIMVI MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjSVZlKSzVyPUG0Mlk6KG6P MWfTRW5ITVJ?
COR-L105 NUW2fHpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXQUpBKSzVyPUG1MlA1KG6P NIH2fYtUSU6JRWK=
P12-ICHIKAWA NYPo[G43T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rpbGlEPTB;MUWuNUBvVQ>? NXrSbWFPW0GQR1XS
CHL-1 NGmwPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL2Vlk6UUN3ME2xOU41PSCwTR?= M{fqPXNCVkeHUh?=
VMRC-RCZ NVnKRpVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTKTWM2OD1zNT62N{BvVQ>? MlLtV2FPT0WU
HH MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF3Lkegcm0> MnrjV2FPT0WU
NUGC-3 M{LnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTF4LkO0JI5O NEHpWldUSU6JRWK=
EGI-1 MlKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ftdmlEPTB;MU[uOFMhdk1? MlrIV2FPT0WU
OS-RC-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF4LkS3JI5O MlvWV2FPT0WU
MOLT-16 NFnyVWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF5LkG1JI5O MVrTRW5ITVJ?
NCI-H209 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrYbJNKSzVyPUG3MlI6KG6P NGL5ZopUSU6JRWK=
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SK-PN-DW NVLpdVJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJ|NT6xPUBvVQ>? M1i1VHNCVkeHUh?=
KM12 NFLqephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\hZ3RDUUN3ME2yN|UvPyCwTR?= MkHXV2FPT0WU
BT-474 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnx[o9KSzVyPUKzOU44OyCwTR?= NHH4OmVUSU6JRWK=
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HT-1197 M4TQXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHKTWM2OD1{M{iuNFkhdk1? M1LLZXNCVkeHUh?=
CAL-54 Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;tbWFKSzVyPUKzPE41QSCwTR?= NYLYWVhbW0GQR1XS
NB10 M3rDOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XtSGlEPTB;MkSwMlA3KG6P NHPiSVVUSU6JRWK=
PANC-10-05 NVH3N21lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjYOYUyUUN3ME2yOFUvPTZibl2= NV31W3FwW0GQR1XS
NCI-H522 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXNR3RKSzVyPUK0PE4{OSCwTR?= MlzSV2FPT0WU
A388 NFW4RYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:4fnhKSzVyPUK0PU45OiCwTR?= M2DhTXNCVkeHUh?=
GOTO M1LUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ3MD6yPUBvVQ>? NGS1ZWtUSU6JRWK=
KLE Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ3MT64O{BvVQ>? NWP1RmxtW0GQR1XS
KYSE-520 NGDyO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XZcWlEPTB;MkWyMlg3KG6P MoDsV2FPT0WU
HCE-4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:4XYxKSzVyPUK2Nk42KG6P M3roc3NCVkeHUh?=
KURAMOCHI M3\yXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvrTWM2OD1{NkWuPUBvVQ>? MnzmV2FPT0WU
HCC38 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf3fohKSzVyPUK2Ok41QCCwTR?= MV;TRW5ITVJ?
FADU MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ4Nj62N{BvVQ>? MYHTRW5ITVJ?
CW-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\acWlEPTB;Mk[5Mlk3KG6P MWLTRW5ITVJ?
L-428 NFXjOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJ5NT6xOUBvVQ>? NVLOUXVEW0GQR1XS
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NCI-H810 NWXvU2pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfCSVJKSzVyPUK3PE4{OSCwTR?= NG\QXWZUSU6JRWK=
LB771-HNC NVrTW4xbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLhTWM2OD1{OEWuPFQhdk1? MkW3V2FPT0WU
LCLC-103H MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\SO2lEPTB;Mki1Mlk6KG6P MkC4V2FPT0WU
EFO-21 M3TESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml25TWM2OD1{OEeuOlghdk1? M3jSOnNCVkeHUh?=
CAL-72 M4W0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJ7Mz6xPUBvVQ>? Mki4V2FPT0WU
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U-87-MG MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LkUmlEPTB;M{CwMlc{KG6P NH\NVWNUSU6JRWK=
MZ7-mel MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnkWVhsUUN3ME2zNlMvPzZibl2= NHLyXYZUSU6JRWK=
NCI-H1770 NGniZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\NVmlEPTB;M{K2Mlc1KG6P M3:0WnNCVkeHUh?=
ChaGo-K-1 NYPPR3RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonETWM2OD1|MkiuNUBvVQ>? NUTiTnNoW0GQR1XS
SiHa MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfBSHRKSzVyPUOyPU4zPCCwTR?= M3;HS3NCVkeHUh?=
NCI-SNU-5 NWC2d21HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\oTWM2OD1|M{[uO|chdk1? M1jKSHNCVkeHUh?=
DJM-1 NXuyVmdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnH[XE2UUN3ME2zOFAvOzNibl2= MV;TRW5ITVJ?
OE19 M2Dnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnKTWlKSzVyPUO0NE42OyCwTR?= MljSV2FPT0WU
NCI-H1651 M3;zdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHfJcoJKSzVyPUO0OE4yQCCwTR?= MVPTRW5ITVJ?
COLO-792 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTN3ND60NkBvVQ>? MVfTRW5ITVJ?
ACHN NX\nWlBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvMbllKSzVyPUO1Ok44OSCwTR?= MYrTRW5ITVJ?
TH-3 NHTrZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTN5OT65OUBvVQ>? NFzjXllUSU6JRWK=
HT-1376 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTN6ND64PEBvVQ>? M2TZeHNCVkeHUh?=
RH-18 NH;FNIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEL6RZFKSzVyPUO5OE44PCCwTR?= M{jsS3NCVkeHUh?=
NB6 NWrQfHNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTN7Nj62OkBvVQ>? MofyV2FPT0WU
COLO-320-HSR NVG4OoJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPOTWM2OD12MEOuN|chdk1? M3jVW3NCVkeHUh?=
UACC-893 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTRyNj60O{BvVQ>? NEfETGNUSU6JRWK=
DSH1 M2HWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWqzbYVsUUN3ME20NFYvQTFibl2= MX7TRW5ITVJ?
TE-10 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDYTWM2OD12MEeuNFEhdk1? NEfCdXBUSU6JRWK=
HCC70 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fuS2lEPTB;NEC5MlIyKG6P NVLHblJyW0GQR1XS
TGBC11TKB NGLLPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHYUW9KSzVyPUSxNE4{OyCwTR?= Mn7tV2FPT0WU
NCI-H727 NEXId|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTRzMj6xNUBvVQ>? NYOzeohjW0GQR1XS
ALL-PO Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTRzNT62PUBvVQ>? MoPVV2FPT0WU
ABC-1 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TCW2lEPTB;NEKwMlQ2KG6P MYTTRW5ITVJ?
NCI-H69 NGnNeVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPEcph5UUN3ME20NlYvPzZibl2= MnnDV2FPT0WU
GP5d MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLxTWM2OD12M{SuOFEhdk1? MVzTRW5ITVJ?
UMC-11 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn1dWk1UUN3ME20OVgvOzZibl2= NHv0No9USU6JRWK=
RMG-I M3flTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{faXmlEPTB;NE[3MlU3KG6P MoPTV2FPT0WU
YAPC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTR7MD62JI5O NG\3dnJUSU6JRWK=
LS-1034 NHq4[3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPzU4g{UUN3ME20PVEvODZibl2= M3LrTHNCVkeHUh?=
RCM-1 M{e1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTPTWM2OD12OU[uOlghdk1? NGSycmxUSU6JRWK=
HCC1954 NFjxUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnVb4JKSzVyPUWxNk42KG6P MWPTRW5ITVJ?
SK-MEL-24 M3rO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD4TWlKSzVyPUWxOk42OSCwTR?= MW\TRW5ITVJ?
NB12 M2rTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXHTWM2OD13MkiuOFIhdk1? M2LyZXNCVkeHUh?=
SW756 M1rGeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3qTWM2OD13NUSuPVYhdk1? NEXXUJJUSU6JRWK=
HCC1187 NF\aXG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTV5NT64N{BvVQ>? NVPU[GpEW0GQR1XS
NCI-H2342 NY\xdVM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3pOmFKSzVyPUW5NE4{QSCwTR?= MX;TRW5ITVJ?
NCI-H2291 NIHr[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnOe2xKSzVyPUW5PE4{OSCwTR?= MYXTRW5ITVJ?
OVCAR-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluwTWM2OD13OUiuPVYhdk1? MV;TRW5ITVJ?
MHH-NB-11 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfzTWM2OD14MkmuNFEhdk1? MkTlV2FPT0WU
SAS NF2xWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfqZYdmUUN3ME22OVIvPjdibl2= NULCV3hFW0GQR1XS
COLO-824 M2DDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HpdmlEPTB;Nki5MlM4KG6P MlLqV2FPT0WU
HCC1395 NYXlVXhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTZ7OD61JI5O NHPtUHFUSU6JRWK=
COLO-668 NEfuSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTdyNj6xJI5O MYrTRW5ITVJ?
NCI-H226 M3nSXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XMW2lEPTB;N{C3Mlghdk1? MmHpV2FPT0WU
NB17 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHz6Z3dKSzVyPUeyNU44PSCwTR?= MWXTRW5ITVJ?
SW1463 NEm4PHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnvWYlDUUN3ME23N|kvOTlibl2= MnzuV2FPT0WU
TGW M{L2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7v[npKSzVyPUe2NE4yPSCwTR?= NEjBXG1USU6JRWK=
NCI-H526 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rVbmlEPTB;OEKzMlU{KG6P MV7TRW5ITVJ?
COR-L88 NXrSepRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTh2OD6xNkBvVQ>? M4fXNnNCVkeHUh?=
NCI-H441 M1nqb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\3OmlEPTB;OEm1MlIzKG6P NWrXWFN{W0GQR1XS
NCI-H630 NHi5XJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzHTWM2OD17MUKuPVYhdk1? NYLoWopkW0GQR1XS
Mo-T Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTl2Nz64PEBvVQ>? M1PDOnNCVkeHUh?=
JAR NVrlV|FbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq4ZldtUUN3ME25OVYvOjRibl2= NHLKVnRUSU6JRWK=
NCI-H1838 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW0TpNKSzVyPUGuNFI{QDhizszN MkTtV2FPT0WU
DoTc2-4510 NEm4elZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M365[GlEPTB;MT6wO|M4PiEQvF2= NIHNV|hUSU6JRWK=
MKN28 M1z5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGKyeIVKSzVyPUGuNFkxOjRizszN NHfNOYhUSU6JRWK=
HuP-T3 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG4TWM2OD1zLkGxPVA2KM7:TR?= NX\LN5NGW0GQR1XS
TE-9 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3JOFNpUUN3ME2xMlEzQTd|IN88US=> NE\RWHFUSU6JRWK=
NY MoTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWxUmY1UUN3ME2xMlE3Pzl{IN88US=> NEPIUWtUSU6JRWK=
HT55 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\USoM{UUN3ME2xMlMyOzR2IN88US=> MmT6V2FPT0WU
SW837 NVPzcZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFwM{K5O|gh|ryP NWDWUnVIW0GQR1XS
NCI-H2029 M4TW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTFwNEG3PVEh|ryP NXjRfHBlW0GQR1XS
IST-SL1 Mnu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXPTWM2OD1zLkS0NlQh|ryP MWDTRW5ITVJ?
COLO-741 M{n1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFwNEm3O|Eh|ryP Ml7NV2FPT0WU
LU-65 NGexVotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXjNFlKSzVyPUGuOlIzPDlizszN MXzTRW5ITVJ?
NCI-H1304 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f1S2lEPTB;MT62OVQ6QCEQvF2= MkP3V2FPT0WU
KARPAS-299 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWzTWM2OD1zLke5OFc6KM7:TR?= M3X1bXNCVkeHUh?=
NCI-H358 NXi4b48zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn2yTWM2OD1zLkm1OVA{KM7:TR?= M{fvT3NCVkeHUh?=
OAW-28 M1jUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjjTWM2OD1{LkC2PVE6KM7:TR?= M4PiNXNCVkeHUh?=
C8166 M{PLVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwNkOzPVIh|ryP MXLTRW5ITVJ?
COLO-678 NF3nXlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHxTWM2OD1{LkizO|Y5KM7:TR?= NW\4PWppW0GQR1XS
SK-N-DZ M3POUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrQbGRKSzVyPUKuPFY{QDFizszN Ml6wV2FPT0WU
NCI-H82 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTJwOUCzOlkh|ryP MWDTRW5ITVJ?
JVM-2 NFjwSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwMEOxPFgh|ryP MWnTRW5ITVJ?
SW1116 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTxTWM2OD1|LkC1OFEyKM7:TR?= NWrq[oVDW0GQR1XS
MDA-MB-453 M4LGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTNwMUC0N|kh|ryP NVnvSpZ7W0GQR1XS
Calu-6 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfMTWM2OD1|LkG5PVch|ryP M3LpeXNCVkeHUh?=
SHP-77 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTNwNUK4JO69VQ>? MVTTRW5ITVJ?
Capan-2 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTRwM{K1PFEh|ryP NHW3d2RUSU6JRWK=
SW948 MkHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTRwN{S3O|kh|ryP MlrtV2FPT0WU
HDLM-2 NIe5cWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jD[2lEPTB;NT6wO|czPSEQvF2= M1rzbXNCVkeHUh?=
LAN-6 M{X1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInPN|dKSzVyPU[uNlE1QTVizszN MUHTRW5ITVJ?
LU-135 NYTWXpBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTZwNEOwO|ch|ryP NEPSZXdUSU6JRWK=
T84 NFHzfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXwWGE2UUN3ME22Mlk5PjRizszN MWLTRW5ITVJ?
CAPAN-1 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX1ZZdKSzVyPUeuOlIzOzNizszN NIPJNYpUSU6JRWK=
SW1417 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTLTWM2OD15LkmxO|MyKM7:TR?= MVXTRW5ITVJ?
BALL-1 NHrGT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXSToRKSzVyPUiuOVA1ODlizszN MVjTRW5ITVJ?
HT-29 MkDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXJTWM2OD17LkC3OVk6KM7:TR?= MXTTRW5ITVJ?
C3A NFHEU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTWTWM2OD17Lki4N|k1KM7:TR?= MXrTRW5ITVJ?
NCI-H1993 NUnSN|lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXmcodKSzVyPUGwMlUxQDFizszN NX6zO4JjW0GQR1XS
SK-MEL-1 NIf2e|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jxc2lEPTB;MUGuOlI5QSEQvF2= MlT6V2FPT0WU
DU-145 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF2LkWwOVIh|ryP NIGydnpUSU6JRWK=
KP-N-YN NWL3fnZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX6fFdKSzVyPUG0MlUyODNizszN NEmyVpZUSU6JRWK=
CCRF-CEM NXvBT49{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF2Lke4NFkh|ryP NVLJfIpWW0GQR1XS
ZR-75-30 NWHyfZJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF4LkOzNFMh|ryP M2fwWXNCVkeHUh?=
A673 NFXRWFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHoTWM2OD1{MD61OVA4KM7:TR?= M37GeXNCVkeHUh?=
K-562 MkDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ6LkSxPFMh|ryP MmW2V2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

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In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

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  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female Harlan athymic nude mice
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+PEG300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms NVP-BEZ235
Smiles CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01856101 Terminated Drug: BEZ235 Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Drug: BEZ235|Drug: Prednisone|Drug: Abiraterone acetate Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01756118 Unknown status Drug: BEZ235 Acute Lymphoblastic Leukemia|Leukemia Myelocytic Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells Johann Wolfgang Goethe University Hospital June 2012 Phase 1
NCT01290406 Withdrawn Drug: BEZ235 Endometrial Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01288092 Withdrawn Drug: BEZ235 Metastatic Breast Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID