Dactolisib (BEZ235)

For research use only.

Catalog No.S1009 Synonyms: NVP-BEZ235

408 publications

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.

Selleck's Dactolisib (BEZ235) has been cited by 408 publications

Purity & Quality Control

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Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NEDqXm9CdnSrbXnjdo9jcWGuIFHzd4F6 MnvwNVghcA>? M3fBSGROW09? MYDBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDhyNUm0Okc,OjR6MEW5OFY9N2F-
MCF7 NXvPSlRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXqwMlAyNTFyMDFOwG0> MlL4OFghcA>? NUTvbm1uTE2VTx?= NYj3Uoh1UUN3ME2wMlc{KM7:TR?= MkDmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{G5NFQoRjJ|OEexPVA1RC:jPh?=
HCT116 NELjT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXZbYQxNjBzLUGwNEDPxE1? NVra[ZJCPDhiaB?= NVLMVm9PTE2VTx?= MnLrTWM2OD1zLkG2JO69VQ>? M1;1SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEexPVA1Lz5{M{i3NVkxPDxxYU6=
U87MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPZOZoxNjBzLUGwNEDPxE1? MnTPOFghcA>? MYrEUXNQ NFXoWVFKSzVyPUGuN|Ih|ryP NXHzdXNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|E6ODRpPkKzPFcyQTB2PD;hQi=>
HBC4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\tdVAvODFvMUCwJO69VQ>? M1zkc|Q5KGh? NHPGTGRNd2diR1m1NF0uQC54MTDN MlHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
BSY1 M1qzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\EVFAvODFvMUCwJO69VQ>? M1XtblQ5KGh? MWjMc4chT0l3ME2tPE41QCCP MoTkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
HBC5 NXfXdVZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3eyOlAvODFvMUCwJO69VQ>? M4XmTFQ5KGh? NWH6[413VG:pIFfJOVA:NTdwOEegUS=> M3rCW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MCF7 Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuwMlAyNTFyMDFOwG0> MoDZOFghcA>? M1;zc2xw\yCJSUWwQU05NjF4IF2= M1m1PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MDA-MB-231 M{HzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PGeFAvODFvMUCwJO69VQ>? MnLqOFghcA>? MX\Mc4chT0l3ME2tPE4xQSCP MmDxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
U251 NEPF[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj2NE4xOS1zMECg{txO NYLyTHZpPDhiaB?= M2jmW2xw\yCJSUWwQU04NjZ4IF2= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SF268 NIDNb3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvSNE4xOS1zMECg{txO M1XLflQ5KGh? NXGyZ2RyVG:pIFfJOVA:NTdwOUKgUS=> Mnf4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SF295 NYL3fnJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHUdW1zOC5yMT2xNFAh|ryP MmnNOFghcA>? MkLkUI9oKEeLNUC9MVgvOzFiTR?= NFHEPYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SF539 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XwNlAvODFvMUCwJO69VQ>? Ml;vOFghcA>? NIPrNmNNd2diR1m1NF0uQC53OTDN MljYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
SNB75 NHr0Z4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGwOYsxNjBzLUGwNEDPxE1? MV[0PEBp NGe1OmZNd2diR1m1NF0uQC53ODDN NHLsNo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
SNB78 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVGwMlAyNTFyMDFOwG0> NFfZbGE1QCCq MUHMc4chT0l3ME2tPE43PSCP MlPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
HCC2998 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljyNE4xOS1zMECg{txO M4DqZVQ5KGh? NH;mOm5Nd2diR1m1NF0uQC5yNTDN M2PwbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
KM12 NFy5O|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU[wMlAyNTFyMDFOwG0> NIOxWpg1QCCq NG[3bmRNd2diR1m1NF0uPy53NDDN M3L6R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HT-29 M1;mOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWiwMlAyNTFyMDFOwG0> MXq0PEBp NVXJO5pmVG:pIFfJOVA:NTdwN{WgUS=> NIjMZpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
HCT15 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHP6WYgxNjBzLUGwNEDPxE1? MmXTOFghcA>? MnHoUI9oKEeLNUC9MVgvODNiTR?= M2HrWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
HCT116 M1zvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHXT2JnOC5yMT2xNFAh|ryP M3zIfVQ5KGh? NYjzd5BtVG:pIFfJOVA:NTdwNkGgUS=> M2PvOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
NCI-H23 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;INE4xOS1zMECg{txO Mon3OFghcA>? NWPsWVAxVG:pIFfJOVA:NTdwNkSgUS=> NF7uPHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H226 M3jEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDYV|UxNjBzLUGwNEDPxE1? NGXkWXM1QCCq NU\uZWdnVG:pIFfJOVA:NThwNESgUS=> NF;IfHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H522 MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3NE4xOS1zMECg{txO NEDQTpA1QCCq MkLaUI9oKEeLNUC9MVgvPDViTR?= NG\0PXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
NCI-H438 NHPNe2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TKUFAvODFvMUCwJO69VQ>? NXfEcZJ5PDhiaB?= NHvRWlJNd2diR1m1NF0uQC5zMTDN NFjsWGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
A549 NH7weZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLiPY13OC5yMT2xNFAh|ryP MorNOFghcA>? NIO5Z3VNd2diR1m1NF0uQC5yNzDN NWLtNJM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
DMS273 NWT6PGdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXKwMlAyNTFyMDFOwG0> MXy0PEBp MoHrUI9oKEeLNUC9MVcvQDBiTR?= NULpTpFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
DMS114 M3fVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX2wMlAyNTFyMDFOwG0> NU[xbpJ{PDhiaB?= MV7Mc4chT0l3ME2tPE4{QSCP NV7ZVXFCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
LOXIMVI M{X0V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6xeJYxNjBzLUGwNEDPxE1? Mlf3OFghcA>? NHzRfGFNd2diR1m1NF0uQC54NjDN MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
OVCAR3 M3vZc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojiNE4xOS1zMECg{txO Mn35OFghcA>? MX;Mc4chT0l3ME2tPE4yPyCP M1vmNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
OVCAR4 NUDLTWlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XqdFAvODFvMUCwJO69VQ>? NUPQTIFjPDhiaB?= MmXjUI9oKEeLNUC9MVgvPThiTR?= NVHxbW1HRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzN|YzPDZpPkKyN|M3OjR4PD;hQi=>
OVCAR5 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rkPFAvODFvMUCwJO69VQ>? NEflOmU1QCCq M1H5Tmxw\yCJSUWwQU04NjV5IF2= NH;HcZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
OVCAR8 NXPCOXc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HYbVAvODFvMUCwJO69VQ>? MmCyOFghcA>? MkG2UI9oKEeLNUC9MVcvQDRiTR?= MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
SKOV3 NYrVNHhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnztNE4xOS1zMECg{txO MkHwOFghcA>? NVnnc|F3VG:pIFfJOVA:NThwNEGgUS=> MknYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
RXF631L NVLHfmRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvOcIl{OC5yMT2xNFAh|ryP MkHNOFghcA>? M3LCeGxw\yCJSUWwQU05NjJzIF2= M2TwTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
ACHN NVrqSm5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWNE4xOS1zMECg{txO NVrDRYt3PDhiaB?= M13XU2xw\yCJSUWwQU04Njl3IF2= MorUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
St-4 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7TNE4xOS1zMECg{txO NFrPb3Y1QCCq MoKyUI9oKEeLNUC9MVcvPDdiTR?= NF\IWlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTMeZFZOC5yMT2xNFAh|ryP NITK[ZQ1QCCq NXrHb5NFVG:pIFfJOVA:NThwNEGgUS=> NIPBNG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN7 M3[3TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULTXJhFOC5yMT2xNFAh|ryP M{DsSFQ5KGh? NHvWT|ZNd2diR1m1NF0uPy54ODDN NF;ZZow9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOzOlI1Pid-MkKzN|YzPDZ:L3G+
MKN28 M1m1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYSwMlAyNTFyMDFOwG0> NFn2Smg1QCCq MmX1UI9oKEeLNUC9MVcvODdiTR?= M3nwVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
MKN45 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYmwMlAyNTFyMDFOwG0> Mn3kOFghcA>? NHTMeWdNd2diR1m1NF0uQC5|NDDN MoDBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|M{[yOFYoRjJ{M{O2NlQ3RC:jPh?=
MKN74 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnG[WMxNjBzLUGwNEDPxE1? MmDuOFghcA>? MlXnUI9oKEeLNUC9MVcvPDJiTR?= M2\2W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{O2NlQ3Lz5{MkOzOlI1PjxxYU6=
DU145 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vnflAvODFvMUCwJO69VQ>? NIj4WHo1QCCq NHq0SoRNd2diR1m1NF0uQC5zNjDN MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN|NkK0Okc,OjJ|M{[yOFY9N2F-
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Trypanosoma brucei brucei M2HwTWZ2dmO2aX;uJGF{e2G7 MkHMNlAxKG6P MmfJNVIhcA>? NEjPb4FFVVOR NFPhR4FG\m[nY4Sgc44heGixc4DoZZRq\HmuY3jvcIlv\SCuZY\lcC=> Mn\lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6MEW5OFYoRjJ2OEC1PVQ3RC:jPh?=
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SBC-1 M4e1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG0emdKSzVyPUe0NkBxVQ>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
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NCI-H720 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmr3TWM2OD1|LkW3JI5O NHfWc|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
BFTC-909 M3zFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfzTWM2OD1|LkexJI5O MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
BPH-1 NHnMUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTRwN{[gcm0> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
PC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnFRnlKSzVyPUWuNFkhdk1? NF;ueWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
AN3-CA MmTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHRcYx5UUN3ME21MlU3KG6P NXH5S5N{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
HN NGTxNGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXPPVNJUUN3ME21Mlk3KG6P MmfKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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KP-4 MkDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTdibl2= M{PWZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
LU-139 M3;2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTdwN{egcm0> NXvpUIVQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
ETK-1 Ml7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Lw[WlEPTB;Nz64PEBvVQ>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
Ramos-2G6-4C10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzXc|lKSzVyPUiuOFkhdk1? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
MHH-PREB-1 NUfqRWZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz4UpFKSzVyPUmuNVIhdk1? NIOxeWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
DU-4475 MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TrdmlEPTB;OT60OEBvVQ>? M2X0T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
NCI-H1666 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzmOpVKSzVyPUmuO|Ehdk1? MlXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
CAMA-1 NW\1NW5YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTIV25qUUN3ME25Mlghdk1? Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
TYK-nu NHP0ZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H5Z2lEPTB;OT65OEBvVQ>? NF\mVGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
MFE-280 M2DJbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:wXWlEPTB;OT65PUBvVQ>? NGX3TWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
A549 NFv3eVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TURWlEPTB;MUCuNVQhdk1? NFLSbo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
769-P NIntOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX3O2hsUUN3ME2xNE41PCCwTR?= M3;zUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
L-363 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTCbIg4UUN3ME2xNE43QSCwTR?= MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
ES8 NGXpcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWC3fVlMUUN3ME2xNE46KG6P NGrxOI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
PA-1 M13IWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fKUGlEPTB;MUGuPFIhdk1? NXH0PG9JRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
Mewo MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTFzLkm5JI5O NXviOoduRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
HSC-3 NGTGU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF{LkKxJI5O MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
H4 NIT5dplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mke1TWM2OD1zMj62O{BvVQ>? Ml3HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
BB65-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fWRWlEPTB;MUKuO|Ihdk1? NHzRXJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
NCI-H1793 MnK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7lWZBKSzVyPUGyMlgzKG6P NH[5[GI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
KARPAS-45 M2PsbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP0cJE6UUN3ME2xN{42OSCwTR?= MmDlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
GCT NGTZd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTF|Lk[4JI5O MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
EoL-1 NGXndFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLqTWM2OD1zMz65N{BvVQ>? NXnnSXpURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
LB2241-RCC Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF2LkCxJI5O NHe3[2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
ES5 MnHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvsTWM2OD1zND63OEBvVQ>? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
LOXIMVI MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fjdWlEPTB;MUSuPVkhdk1? M175dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
COR-L105 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXRTWM2OD1zNT6wOEBvVQ>? M3vyOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
P12-ICHIKAWA MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHNTWM2OD1zNT6xJI5O MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
CHL-1 NVHpPYo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TjcmlEPTB;MUWuOFUhdk1? Ml\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
VMRC-RCZ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXLb2lKSzVyPUG1MlY{KG6P NIPiVmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
HH M2n3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlX6TWM2OD1zNT63JI5O NGHMVno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
NUGC-3 MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rHc2lEPTB;MU[uN|Qhdk1? NUDxUnhQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
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OVCAR-5 M{m5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXsTWM2OD1|NT60O{BvVQ>? Mn3PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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CAL-39 NFSwcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jaTmlEPTB;M{euPUBvVQ>? Mn\vQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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SJSA-1 NGn2[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr1TWM2OD1|OD61OEBvVQ>? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
CAL-12T MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7SUYlJUUN3ME2zPE43KG6P MlTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
HCC1419 MmP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n4fWlEPTB;M{iuO|Ehdk1? NUXJSJJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
CO-314 M33rWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T6PWlEPTB;M{iuO|Qhdk1? MnPPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
LB1047-RCC NEO5SGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rZZWlEPTB;M{iuPFEhdk1? M4P5RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
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MZ2-MEL MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXhW5JEUUN3ME2zPU43PiCwTR?= NHfaS3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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G-401 MoT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTRyLkiyJI5O M{HBT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
HT MkT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vCT2lEPTB;NEGuNFIhdk1? NFjx[Xg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
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NTERA-S-cl-D1 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nSfWlEPTB;NEOgcm0> NVnVSWoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
T-24 M4TKO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnhTppYUUN3ME20N{45OyCwTR?= MnzGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
EPLC-272H MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3KVJJKSzVyPUS0MlM6KG6P MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
PSN1 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvBXGhHUUN3ME20OE41KG6P NWTiN41PRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
NCI-H2452 NWX1[ZNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXiPJpKSzVyPUS0MlU5KG6P M2DmOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
KS-1 NHfDSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH33emtKSzVyPUS0MlY3KG6P M3PYSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
HD-MY-Z NHXiRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jSS2lEPTB;NESuPVIhdk1? NGfMZ4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
KNS-62 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;1UZByUUN3ME20OU4{QCCwTR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
NOMO-1 NF7rcW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HKSWlEPTB;NEWuPFchdk1? NYXWcJJkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
SK-HEP-1 MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX6d|JKSzVyPUS2MlA1KG6P M2PHbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
IGR-1 Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HVUmlEPTB;NE[uNVMhdk1? M3zuSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
KYSE-180 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7CWWlWUUN3ME20Ok4yPyCwTR?= MnuwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
EW-22 Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HMRmlEPTB;NE[uNkBvVQ>? M2TVdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
NCI-H1355 MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2j0dWlEPTB;NE[uN|Qhdk1? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
DOHH-2 NH\CZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTR4LkO3JI5O MmH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
A4-Fuk NWHpZXFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTOfGRLUUN3ME20Ok42OiCwTR?= Mn[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
PC-14 MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[4UFNQUUN3ME20Ok42PyCwTR?= Mlv6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
TE-5 M1XLSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTR4Lki0JI5O MmPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
LB996-RCC M2LXfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLOdHQ4UUN3ME20O{4yQSCwTR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
NCI-H1623 NVPWZ41{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTR5Lke2JI5O NFPvNog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
NCI-H1155 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojTTWM2OD12OD6zNkBvVQ>? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
LoVo MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVS4b|RIUUN3ME20PE41KG6P MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
MCF7 NFLxdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPLZ2lWUUN3ME20PE42QCCwTR?= NEfoV|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
AGS NWH0[YxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDOTWM2OD12OD63O{BvVQ>? NGHBVXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
PFSK-1 M4LPXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHJTWM2OD12OT6wOkBvVQ>? M1HZ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
22RV1 NF6yc3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Pld2lEPTB;NEmuNFkhdk1? MmDGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
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OAW-28 NXHvc|lST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzOWZhKUUN3ME2yMlA3QTF7IN88US=> MmnkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
C8166 NXO1OYJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofaTWM2OD1{Lk[zN|kzKM7:TR?= NXi2VYRKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
COLO-678 M2fuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHOdXRKSzVyPUKuPFM4PjhizszN MmjQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
SK-N-DZ M2fveGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJwOE[zPFEh|ryP NFnh[VM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
NCI-H82 NXqx[2hzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHETWM2OD1{LkmwN|Y6KM7:TR?= MlvVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
JVM-2 M4jsR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETUN2JKSzVyPUOuNFMyQDhizszN M4KxU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
SW1116 NF;nT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwMEW0NVEh|ryP MkPHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
MDA-MB-453 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfTSnFKSzVyPUOuNVA1OzlizszN MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
Calu-6 NUO5[oJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P5RWlEPTB;Mz6xPVk4KM7:TR?= NVXVXFhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
SHP-77 NWq5dmpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnPUXhKSzVyPUOuOVI5KM7:TR?= NGTaOmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
Capan-2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTRwM{K1PFEh|ryP M4TvV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
SW948 M{L2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLLTWM2OD12Lke0O|c6KM7:TR?= NH3ZO5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
HDLM-2 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTYbmpKSzVyPUWuNFc4OjVizszN M{XtPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
LAN-6 MmHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTZwMkG0PVUh|ryP NXzGfWZsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
LU-135 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPzTWM2OD14LkSzNFc4KM7:TR?= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
T84 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnnTWM2OD14Lkm4OlQh|ryP MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
CAPAN-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfTbHRtUUN3ME23MlYzOjN|IN88US=> NYLQboJwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
SW1417 M2POcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTdwOUG3N|Eh|ryP Mkj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
BALL-1 NFv1Zo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRThwNUC0NFkh|ryP NWfqcWNuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNOTh5OUS2N{8oRlODTlfFVlww[T5?
HT-29 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTlwMEe1PVkh|ryP M{D1UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
C3A NF3LfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3xWFBKSzVyPUmuPFg{QTRizszN MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVg4QTR4Mz:nQnNCVkeHUkyvZV4>
NCI-H1993 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[wWmlEPTB;MUCuOVA5OSEQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
SK-MEL-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFzLk[yPFkh|ryP NFXxOnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
DU-145 M4mxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7xfY15UUN3ME2xOE42ODV{IN88US=> M2[2dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
KP-N-YN NVK1TYVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPNTWM2OD1zND61NVA{KM7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyxPFc6PDZ|Lze+V2FPT0WUPD;hQi=>
CCRF-CEM NYjpZ5NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX3eXdKSzVyPUG0Mlc5ODlizszN M3HVeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,
ZR-75-30 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITSfoxKSzVyPUG2MlM{ODNizszN NIH0O5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
A673 NWTDXGJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q4O2lEPTB;MkCuOVUxPyEQvF2= NF76U|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmwyQDd7NE[zM{c,W0GQR1XSQE9iRg>?
K-562 NV:4RnZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Oc2JKSzVyPUK4MlQyQDNizszN M4nS[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFE5Pzl2NkOvK|5USU6JRWK8M4E,

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

- Collapse

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

- Collapse
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female Harlan athymic nude mice
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+PEG300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms NVP-BEZ235
Smiles CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01856101 Terminated Drug: BEZ235 Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Drug: BEZ235|Drug: Prednisone|Drug: Abiraterone acetate Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01756118 Unknown status Drug: BEZ235 Acute Lymphoblastic Leukemia|Leukemia Myelocytic Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells Johann Wolfgang Goethe University Hospital June 2012 Phase 1
NCT01290406 Withdrawn Drug: BEZ235 Endometrial Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01288092 Withdrawn Drug: BEZ235 Metastatic Breast Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID