Dactolisib (BEZ235)

For research use only. Not for use in humans.

Catalog No.S1009 Synonyms: NVP-BEZ235

258 publications

Dactolisib (BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

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Selleck's Dactolisib (BEZ235) has been cited by 258 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NFqzVWpCdnSrbXnjdo9jcWGuIFHzd4F6 M1fGdFE5KGh? NIj6bWFFVVOR NUj6UZVjSW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= M4C4UVI1QDB3OUS2
MCF7 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF[ybFQxNjBzLUGwNEDPxE1? M4rDWFQ5KGh? MoPESG1UVw>? MWTJR|UxRTBwN{Og{txO M1O2UVI{QDdzOUC0
HCT116 NYn3eZlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUewMlAyNTFyMDFOwG0> MWm0PEBp NG\IT2pFVVOR MX7JR|UxRTFwMU[g{txO MmTNNlM5PzF7MES=
U87MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL5OllsOC5yMT2xNFAh|ryP NVy4XG5ZPDhiaB?= NYnsUIp{TE2VTx?= M3XTZ2lEPTB;MT6zNkDPxE1? MUGyN|g4OTlyNB?=
HBC4 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHBO3o3OC5yMT2xNFAh|ryP NEXhSXQ1QCCq M4fQfGxw\yCJSUWwQU05NjZzIF2= NV3kfmduOjJ|M{[yOFY>
BSY1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrF[YUyOC5yMT2xNFAh|ryP MlnQOFghcA>? MmrnUI9oKEeLNUC9MVgvPDhiTR?= NXPZc2xrOjJ|M{[yOFY>
HBC5 MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[xRlAvODFvMUCwJO69VQ>? NEi3e|E1QCCq M13tN2xw\yCJSUWwQU04Njh5IF2= M3fzblIzOzN4MkS2
MCF7 MnX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3LdmtZOC5yMT2xNFAh|ryP NEPtW5c1QCCq NWP0bYtOVG:pIFfJOVA:NThwMU[gUS=> MX[yNlM{PjJ2Nh?=
MDA-MB-231 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnlNE4xOS1zMECg{txO MYC0PEBp NUPJSWtwVG:pIFfJOVA:NThwMEmgUS=> NF7G[XEzOjN|NkK0Oi=>
U251 M4L6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTCNE4xOS1zMECg{txO MkfCOFghcA>? Mnr0UI9oKEeLNUC9MVcvPjZiTR?= MYiyNlM{PjJ2Nh?=
SF268 NYmzUpVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPWNE4xOS1zMECg{txO M3HvdVQ5KGh? MmP0UI9oKEeLNUC9MVcvQTJiTR?= NEnwZ4kzOjN|NkK0Oi=>
SF295 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqwWYgxNjBzLUGwNEDPxE1? MWS0PEBp NVi4eHlLVG:pIFfJOVA:NThwM{GgUS=> MUSyNlM{PjJ2Nh?=
SF539 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSwMlAyNTFyMDFOwG0> M{e3[FQ5KGh? MkjmUI9oKEeLNUC9MVgvPTliTR?= NH75cIQzOjN|NkK0Oi=>
SNB75 NXj2VlEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWGwMlAyNTFyMDFOwG0> M4nQWVQ5KGh? NWrie45xVG:pIFfJOVA:NThwNUigUS=> NGDhNFUzOjN|NkK0Oi=>
SNB78 NWLJNIM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nhb|AvODFvMUCwJO69VQ>? MVy0PEBp NE\EZWRNd2diR1m1NF0uQC54NTDN MX2yNlM{PjJ2Nh?=
HCC2998 NXy2WZlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmqyNE4xOS1zMECg{txO M13Ec|Q5KGh? MX\Mc4chT0l3ME2tPE4xPSCP NHHvUlIzOjN|NkK0Oi=>
KM12 NF\nd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:wMlAyNTFyMDFOwG0> MXe0PEBp NHrqeJBNd2diR1m1NF0uPy53NDDN Ml3nNlI{OzZ{NE[=
HT-29 NGHhXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfLSWg4OC5yMT2xNFAh|ryP NUD1R4F{PDhiaB?= M3n1RWxw\yCJSUWwQU04Njd3IF2= NUD6PWZvOjJ|M{[yOFY>
HCT15 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYi2b5BzOC5yMT2xNFAh|ryP MWK0PEBp NV;DfFlYVG:pIFfJOVA:NThwMEOgUS=> NGrBR5ozOjN|NkK0Oi=>
HCT116 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWmwMlAyNTFyMDFOwG0> NXXWPW5NPDhiaB?= MnTOUI9oKEeLNUC9MVcvPjFiTR?= NUfpPWtJOjJ|M{[yOFY>
NCI-H23 M3ryNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf4[XRmOC5yMT2xNFAh|ryP M3LP[|Q5KGh? M3TPNGxw\yCJSUWwQU04NjZ2IF2= NH:xNWEzOjN|NkK0Oi=>
NCI-H226 NW\mT5hVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrSUJMxNjBzLUGwNEDPxE1? M1;6dVQ5KGh? Mof1UI9oKEeLNUC9MVgvPDRiTR?= NIHYdVYzOjN|NkK0Oi=>
NCI-H522 NWPrcWs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK3NE4xOS1zMECg{txO NFvDcoU1QCCq MmLIUI9oKEeLNUC9MVgvPDViTR?= NGT0NpYzOjN|NkK0Oi=>
NCI-H438 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP5NE4xOS1zMECg{txO MUO0PEBp M1r6cGxw\yCJSUWwQU05NjFzIF2= M2S1e|IzOzN4MkS2
A549 NF;2dFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfSNE4xOS1zMECg{txO M3XDZ|Q5KGh? MlvXUI9oKEeLNUC9MVgvODdiTR?= MlfKNlI{OzZ{NE[=
DMS273 M1qw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TKOlAvODFvMUCwJO69VQ>? M4jYR|Q5KGh? MorWUI9oKEeLNUC9MVcvQDBiTR?= MmHFNlI{OzZ{NE[=
DMS114 NFfmPWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDk[nYxNjBzLUGwNEDPxE1? NWHtR21ZPDhiaB?= NWH6T4duVG:pIFfJOVA:NThwM{mgUS=> NXfx[JVFOjJ|M{[yOFY>
LOXIMVI M{TsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi1U4czOC5yMT2xNFAh|ryP M37oNFQ5KGh? NVPHVZlpVG:pIFfJOVA:NThwNk[gUS=> NVnsOohDOjJ|M{[yOFY>
OVCAR3 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LRe|AvODFvMUCwJO69VQ>? M1zMRVQ5KGh? M3SwfGxw\yCJSUWwQU05NjF5IF2= MkfhNlI{OzZ{NE[=
OVCAR4 NX3kT3VET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nINVAvODFvMUCwJO69VQ>? M1jPUFQ5KGh? NUnkZpRvVG:pIFfJOVA:NThwNUigUS=> MWqyNlM{PjJ2Nh?=
OVCAR5 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3W2NlAvODFvMUCwJO69VQ>? NEDXOFM1QCCq MlXHUI9oKEeLNUC9MVcvPTdiTR?= Mn2wNlI{OzZ{NE[=
OVCAR8 NHy3d2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPqUYFZOC5yMT2xNFAh|ryP Mm\zOFghcA>? M2nnW2xw\yCJSUWwQU04Njh2IF2= NFnrd3UzOjN|NkK0Oi=>
SKOV3 M3T5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHvWJpGOC5yMT2xNFAh|ryP M2nae|Q5KGh? MkDxUI9oKEeLNUC9MVgvPDFiTR?= M1XkV|IzOzN4MkS2
RXF631L M2nVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mli0NE4xOS1zMECg{txO M1K0V|Q5KGh? NYr0WoFGVG:pIFfJOVA:NThwMkGgUS=> NH3pemQzOjN|NkK0Oi=>
ACHN Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUiwMlAyNTFyMDFOwG0> M4XwRlQ5KGh? NFzuOVFNd2diR1m1NF0uPy57NTDN MoTvNlI{OzZ{NE[=
St-4 NXL6Vlg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnqWmp7OC5yMT2xNFAh|ryP NWGzRll3PDhiaB?= MkHFUI9oKEeLNUC9MVcvPDdiTR?= NV\JWZFJOjJ|M{[yOFY>
MKN1 M3LVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DPNVAvODFvMUCwJO69VQ>? NXjiRmxVPDhiaB?= NUDqe44{VG:pIFfJOVA:NThwNEGgUS=> MXGyNlM{PjJ2Nh?=
MKN7 NHLBTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr5cFIxNjBzLUGwNEDPxE1? MYe0PEBp NIC2W5lNd2diR1m1NF0uPy54ODDN MUeyNlM{PjJ2Nh?=
MKN28 NIXmSotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYewMlAyNTFyMDFOwG0> NWSyPWNRPDhiaB?= M{XaW2xw\yCJSUWwQU04NjB5IF2= MVGyNlM{PjJ2Nh?=
MKN45 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGwMlAyNTFyMDFOwG0> NWrzdXBzPDhiaB?= NUjOWFdjVG:pIFfJOVA:NThwM{SgUS=> NVzoeINCOjJ|M{[yOFY>
MKN74 NYnJTFdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrUXnUxNjBzLUGwNEDPxE1? MXG0PEBp M3;ROmxw\yCJSUWwQU04NjR{IF2= NETyOm4zOjN|NkK0Oi=>
DU145 MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYToNW85OC5yMT2xNFAh|ryP MYq0PEBp MlXWUI9oKEeLNUC9MVgvOTZiTR?= M3ftcFIzOzN4MkS2
PC3 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknFNE4xOS1zMECg{txO MXK0PEBp NVvxe3ByVG:pIFfJOVA:NThwNk[gUS=> M3r1blIzOzN4MkS2
Trypanosoma brucei brucei NWHUXXRzTnWwY4Tpc44hSXO|YYm= MUeyNFAhdk1? MmrFNVIhcA>? NX:xXo5xTE2VTx?= MUfE[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt NEnWV4kzPDhyNUm0Oi=>
Trypanosoma brucei brucei M2Dy[GZ2dmO2aX;uJGF{e2G7 M1;wS|E5KGh? NHz1OpZFVVOR MlrnTY5pcWKrdHnvckBw\iC{ZXPldJRwei2vZXTpZZRm\CCnbnTvZ5l1d3OrczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC2cnHud4ZmenKrbjD1dJRic2V? MorzNlQ5ODV7NE[=
Trypanosoma brucei brucei MmXTSpVv[3Srb36gRZN{[Xl? MXuyNFAhdk1? MU[xNkBp M1T1T2ROW09? MUXF[oZm[3Rib36gd5BpcW6pb335cIVqdiCuZY\lcC=> NWDGeGd7OjR6MEW5OFY>
Trypanosoma brucei brucei NGP6coZHfW6ldHnvckBCe3OjeR?= NIHJPJozODBibl2= NFewfVQyOiCq NWTtOVI3TE2VTx?= NI\2N4FG\m[nY4Sgc44heGixc4DoZZRq\HmuY3jvcIlv\SCuZY\lcC=> NETpdFkzPDhyNUm0Oi=>
UM-UC-3 MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTNzNTDwUS=> NH;m[5hUSU6JRWK=
SBC-1 M1j0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7HTWM2OD15NEKgdG0> MWfTRW5ITVJ?
MKN1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELFRoNKSzVyPUKuPEBvVQ>? M1zIfnNCVkeHUh?=
NCI-H720 MnO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTNwNUegcm0> MV;TRW5ITVJ?
BFTC-909 M{DZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjveZRRUUN3ME2zMlcyKG6P MVjTRW5ITVJ?
BPH-1 NFLMfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\xR2lEPTB;ND63OkBvVQ>? MXPTRW5ITVJ?
PC-3 NFnPZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfRcFZKSzVyPUWuNFkhdk1? NGjkcllUSU6JRWK=
AN3-CA MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTVwNU[gcm0> M{\Kc3NCVkeHUh?=
HN MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfYVY5TUUN3ME21Mlk3KG6P MX7TRW5ITVJ?
HCC2218 MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfJ[XFZUUN3ME22MlYyKG6P NX\Sclc2W0GQR1XS
KP-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoraTWM2OD15IH7N MoT6V2FPT0WU
LU-139 NWCxRXZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTdwN{egcm0> MYTTRW5ITVJ?
ETK-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPNTmJKSzVyPUeuPFghdk1? M33RZ3NCVkeHUh?=
Ramos-2G6-4C10 NV3DRXNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRThwNEmgcm0> MnjpV2FPT0WU
MHH-PREB-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTlwMUKgcm0> NGnIcVdUSU6JRWK=
DU-4475 NEX6VFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH1XFZYUUN3ME25MlQ1KG6P M{PRU3NCVkeHUh?=
NCI-H1666 NV7sbod3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzwZ4s6UUN3ME25MlcyKG6P MUnTRW5ITVJ?
CAMA-1 M{X0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rNV2lEPTB;OT64JI5O M4TneHNCVkeHUh?=
TYK-nu NGrEZYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPwbJhKSzVyPUmuPVQhdk1? NIXLZoJUSU6JRWK=
MFE-280 NVrN[pVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTlwOUmgcm0> Mn\PV2FPT0WU
A549 NV\ifI5ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoW0TWM2OD1zMD6xOEBvVQ>? MXvTRW5ITVJ?
769-P M3mxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjXNW5kUUN3ME2xNE41PCCwTR?= MmrnV2FPT0WU
L-363 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LPRmlEPTB;MUCuOlkhdk1? MVPTRW5ITVJ?
ES8 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PxZWlEPTB;MUCuPUBvVQ>? NX3YZYpKW0GQR1XS
PA-1 NFrPc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrUTWM2OD1zMT64NkBvVQ>? NFf2V4tUSU6JRWK=
Mewo MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFzLkm5JI5O MmS1V2FPT0WU
HSC-3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPUTWM2OD1zMj6yNUBvVQ>? NF\UVlZUSU6JRWK=
H4 M{m1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULQNmFvUUN3ME2xNk43PyCwTR?= NFjlU2RUSU6JRWK=
BB65-RCC NGDlbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF{LkeyJI5O NUTofYdlW0GQR1XS
NCI-H1793 NHjuR5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPLTWM2OD1zMj64NkBvVQ>? NH73VmNUSU6JRWK=
KARPAS-45 NYjtTXF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjtSGd{UUN3ME2xN{42OSCwTR?= M1zjfnNCVkeHUh?=
GCT NU[0WYNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInZSJBKSzVyPUGzMlY5KG6P NGfsRVhUSU6JRWK=
EoL-1 NVrWem1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TXOGlEPTB;MUOuPVMhdk1? NWj2SYI5W0GQR1XS
LB2241-RCC M{HMO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF2LkCxJI5O MlTqV2FPT0WU
ES5 NFP6XVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PicmlEPTB;MUSuO|Qhdk1? MWHTRW5ITVJ?
LOXIMVI M3\Fe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXJelFKSzVyPUG0Mlk6KG6P NFizb2lUSU6JRWK=
COR-L105 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPITWM2OD1zNT6wOEBvVQ>? M2C5T3NCVkeHUh?=
P12-ICHIKAWA MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO3codKSzVyPUG1MlEhdk1? NXfjd2w6W0GQR1XS
CHL-1 NFjVcGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13LWWlEPTB;MUWuOFUhdk1? MW\TRW5ITVJ?
VMRC-RCZ MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LGUmlEPTB;MUWuOlMhdk1? MnvUV2FPT0WU
HH MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF3Lkegcm0> M1TOZXNCVkeHUh?=
NUGC-3 M1exdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF4LkO0JI5O Mn72V2FPT0WU
EGI-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Txd2lEPTB;MU[uOFMhdk1? MmfzV2FPT0WU
OS-RC-2 NU\FRmtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\xdnNKSzVyPUG2MlQ4KG6P MUjTRW5ITVJ?
MOLT-16 M{iycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGiz[GNKSzVyPUG3MlE2KG6P MoHFV2FPT0WU
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KM12 NHPqdoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\6TWM2OD1{M{WuO{BvVQ>? NIXtWpBUSU6JRWK=
BT-474 NX;IZngxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ|NT63N{BvVQ>? NU\NZlNIW0GQR1XS
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CAL-54 M2eye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnewTWM2OD1{M{iuOFkhdk1? NF[4PWVUSU6JRWK=
NB10 NYHFRlVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPMOo1ZUUN3ME2yOFAvODZibl2= MlftV2FPT0WU
PANC-10-05 Moq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WzUGlEPTB;MkS1MlU3KG6P NXflWJBpW0GQR1XS
NCI-H522 NIPUN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTPPIx3UUN3ME2yOFgvOzFibl2= MXzTRW5ITVJ?
A388 MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ2OT64NkBvVQ>? NWOwfXQ3W0GQR1XS
GOTO Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fzWWlEPTB;MkWwMlI6KG6P MXzTRW5ITVJ?
KLE MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfUU4lrUUN3ME2yOVEvQDdibl2= MWDTRW5ITVJ?
KYSE-520 NHzBcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fCZmlEPTB;MkWyMlg3KG6P M{P1d3NCVkeHUh?=
HCE-4 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\FO4s5UUN3ME2yOlIvPSCwTR?= NIHlSm5USU6JRWK=
KURAMOCHI NXvMNphFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\GW5VCUUN3ME2yOlUvQSCwTR?= Mo\nV2FPT0WU
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FADU NHvoNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXhR5pKSzVyPUK2Ok43OyCwTR?= Mn;RV2FPT0WU
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HCC1569 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVThdGZ2UUN3ME2yO|UvQDRibl2= NIPJdZNUSU6JRWK=
NCI-H810 NYLOWXVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17GV2lEPTB;Mke4MlMyKG6P NH;ZPVRUSU6JRWK=
LB771-HNC NYnycY5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXrTWM2OD1{OEWuPFQhdk1? NH3aNppUSU6JRWK=
LCLC-103H MkOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3FU49KSzVyPUK4OU46QSCwTR?= Mnq4V2FPT0WU
EFO-21 NFOzVYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHH5OXBKSzVyPUK4O{43QCCwTR?= MmW0V2FPT0WU
CAL-72 NGXjW|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j5UmlEPTB;MkmzMlE6KG6P NIPJRVhUSU6JRWK=
SCC-9 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;jTJFrUUN3ME2yPVMvOjJibl2= NHizS3hUSU6JRWK=
COLO-829 NWfJb213T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvRZphDUUN3ME2yPVYvPSCwTR?= NEjCPItUSU6JRWK=
U-87-MG NVjrSWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNyMD63N{BvVQ>? MojBV2FPT0WU
MZ7-mel NGP5T5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGexe41KSzVyPUOyN{44PiCwTR?= NVK3d3FyW0GQR1XS
NCI-H1770 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTN{Nj63OEBvVQ>? MVzTRW5ITVJ?
ChaGo-K-1 NI\3cWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGyT2htUUN3ME2zNlgvOSCwTR?= NGHPeIpUSU6JRWK=
SiHa NFrwWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi5OVdoUUN3ME2zNlkvOjRibl2= NUjqZ4hOW0GQR1XS
NCI-SNU-5 NFjwRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[1XGFSUUN3ME2zN|YvPzdibl2= Ml\xV2FPT0WU
DJM-1 NV6yc5d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXZTWM2OD1|NECuN|Mhdk1? MW\TRW5ITVJ?
OE19 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPjWFMzUUN3ME2zOFAvPTNibl2= M2LjSnNCVkeHUh?=
NCI-H1651 MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLEZWFKSzVyPUO0OE4yQCCwTR?= NVTXXIp1W0GQR1XS
COLO-792 M{mwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7EbVM3UUN3ME2zOVQvPDJibl2= MYjTRW5ITVJ?
ACHN NVT6SHNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTN3Nj63NUBvVQ>? NXjnNVViW0GQR1XS
TH-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTN5OT65OUBvVQ>? MnPKV2FPT0WU
HT-1376 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nEOWlEPTB;M{i0Mlg5KG6P MlnlV2FPT0WU
RH-18 NFS3[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLDTWM2OD1|OUSuO|Qhdk1? M2XvO3NCVkeHUh?=
NB6 NEfJfHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n1PWlEPTB;M{m2MlY3KG6P Mn3KV2FPT0WU
COLO-320-HSR NH7QbGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOwTWM2OD12MEOuN|chdk1? MYXTRW5ITVJ?
UACC-893 NHHsRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLjeHdKSzVyPUSwOk41PyCwTR?= NXrod2FkW0GQR1XS
DSH1 NUHUV3JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDLNIlKSzVyPUSwOk46OSCwTR?= MlHGV2FPT0WU
TE-10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X2PWlEPTB;NEC3MlAyKG6P NX\X[ZdJW0GQR1XS
HCC70 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XrRmlEPTB;NEC5MlIyKG6P NVXDc4Z1W0GQR1XS
TGBC11TKB NEXtRpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnflTWM2OD12MUCuN|Mhdk1? MkXNV2FPT0WU
NCI-H727 MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTRzMj6xNUBvVQ>? Ml;YV2FPT0WU
ALL-PO MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXwOHRzUUN3ME20NVUvPjlibl2= NYPJblhCW0GQR1XS
ABC-1 M2e4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTR{MD60OUBvVQ>? M2rvfHNCVkeHUh?=
NCI-H69 NV;yVHlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y5NmlEPTB;NEK2Mlc3KG6P MonKV2FPT0WU
GP5d MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7WV3FKSzVyPUSzOE41OSCwTR?= NVfJeIh5W0GQR1XS
UMC-11 NF;TbIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTnOWNKSzVyPUS1PE4{PiCwTR?= M13m[XNCVkeHUh?=
RMG-I NYDtfmdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFflWVJKSzVyPUS2O{42PiCwTR?= NFm3ToVUSU6JRWK=
YAPC M1W3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jpNmlEPTB;NEmwMlYhdk1? M3PZXnNCVkeHUh?=
LS-1034 NI\VeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETsNHBKSzVyPUS5NU4xPiCwTR?= MYTTRW5ITVJ?
RCM-1 M1H1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTR7Nj62PEBvVQ>? MoDuV2FPT0WU
HCC1954 NELzOotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTVzMj61JI5O MnvGV2FPT0WU
SK-MEL-24 NVvJcXJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvBWGJKSzVyPUWxOk42OSCwTR?= MnK2V2FPT0WU
NB12 Mlj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;xV5A3UUN3ME21NlgvPDJibl2= NUL0fGJQW0GQR1XS
SW756 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrLd2VKSzVyPUW1OE46PiCwTR?= MkXQV2FPT0WU
HCC1187 NIXVboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PjZ2lEPTB;NUe1Mlg{KG6P MVHTRW5ITVJ?
NCI-H2342 M2[yemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjsSmx3UUN3ME21PVAvOzlibl2= NV3aOIpbW0GQR1XS
NCI-H2291 M1LVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\kTWM2OD13OUiuN|Ehdk1? MWXTRW5ITVJ?
OVCAR-3 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33wXGlEPTB;NUm4Mlk3KG6P MU\TRW5ITVJ?
MHH-NB-11 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXZUGhsUUN3ME22NlkvODFibl2= NXi4SW5GW0GQR1XS
SAS NX7OfJdJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknyTWM2OD14NUKuOlchdk1? MVPTRW5ITVJ?
COLO-824 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXWTWM2OD14OEmuN|chdk1? NGixToNUSU6JRWK=
HCC1395 Ml7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjUfYJ2UUN3ME22PVgvPSCwTR?= MmTXV2FPT0WU
COLO-668 M36xOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXSO4dyUUN3ME23NFYvOSCwTR?= NWfFRotqW0GQR1XS
NCI-H226 MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLpSIZKSzVyPUewO{45KG6P Ml;vV2FPT0WU
NB17 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTd{MT63OUBvVQ>? MlLnV2FPT0WU
SW1463 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[wUY9KSzVyPUezPU4yQSCwTR?= NF3mN3ZUSU6JRWK=
TGW M4TJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTd4MD6xOUBvVQ>? MnTyV2FPT0WU
NCI-H526 NVHIOWhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTBe|lUUUN3ME24NlMvPTNibl2= NXzJfG9{W0GQR1XS
COR-L88 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPFfllKSzVyPUi0PE4yOiCwTR?= M3XhV3NCVkeHUh?=
NCI-H441 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTh7NT6yNkBvVQ>? NIqzeZBUSU6JRWK=
NCI-H630 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr5OGtKSzVyPUmxNk46PiCwTR?= MonHV2FPT0WU
Mo-T MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTl2Nz64PEBvVQ>? NVW2fGdHW0GQR1XS
JAR MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fXUGlEPTB;OUW2MlI1KG6P MmTaV2FPT0WU
NCI-H1838 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwMEKzPFgh|ryP NHjwd2hUSU6JRWK=
DoTc2-4510 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1T3RmlEPTB;MT6wO|M4PiEQvF2= NInRTGRUSU6JRWK=
MKN28 NGf0cWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS3W|ZKSzVyPUGuNFkxOjRizszN MYDTRW5ITVJ?
HuP-T3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGG5W5RKSzVyPUGuNVE6ODVizszN NGnYeIZUSU6JRWK=
TE-9 Mk\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTFwMUK5O|Mh|ryP M{\re3NCVkeHUh?=
NY MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnETWM2OD1zLkG2O|kzKM7:TR?= MVnTRW5ITVJ?
HT55 M4HCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0UXh1UUN3ME2xMlMyOzR2IN88US=> M4rtVHNCVkeHUh?=
SW837 M1rNdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrvS4hKSzVyPUGuN|I6PzhizszN NY[3OYZRW0GQR1XS
NCI-H2029 NV\Z[GdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPkN2R5UUN3ME2xMlQyPzlzIN88US=> M3PtUXNCVkeHUh?=
IST-SL1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTFwNESyOEDPxE1? NEjyTlBUSU6JRWK=
COLO-741 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVe0Z3VUUUN3ME2xMlQ6PzdzIN88US=> NUHJUWhUW0GQR1XS
LU-65 M3[yXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjpTWM2OD1zLk[yNlQ6KM7:TR?= MYTTRW5ITVJ?
NCI-H1304 NV;5S5UyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjyTWM2OD1zLk[1OFk5KM7:TR?= M3fN[HNCVkeHUh?=
KARPAS-299 NXq1PVFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7MTWM2OD1zLke5OFc6KM7:TR?= MV;TRW5ITVJ?
NCI-H358 NYPKTmJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXBbIlKSzVyPUGuPVU2ODNizszN M3fFO3NCVkeHUh?=
OAW-28 MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDpco97UUN3ME2yMlA3QTF7IN88US=> MnfUV2FPT0WU
C8166 NUDX[GZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvvfI9qUUN3ME2yMlY{Ozl{IN88US=> MkT4V2FPT0WU
COLO-678 M1HyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zC[mlEPTB;Mj64N|c3QCEQvF2= MnvjV2FPT0WU
SK-N-DZ MlfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\KTI94UUN3ME2yMlg3OzhzIN88US=> MUTTRW5ITVJ?
NCI-H82 M3\lcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInDZZNKSzVyPUKuPVA{PjlizszN NWfUeHF3W0GQR1XS
JVM-2 MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnGxTWM2OD1|LkCzNVg5KM7:TR?= NVTJO3RuW0GQR1XS
SW1116 NGfsW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTNwMEW0NVEh|ryP NVX0NFl6W0GQR1XS
MDA-MB-453 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG1SlYxUUN3ME2zMlExPDN7IN88US=> NGm3dXlUSU6JRWK=
Calu-6 NFrDVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WxWmlEPTB;Mz6xPVk4KM7:TR?= MnexV2FPT0WU
SHP-77 NWnrcoY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3H1R2lEPTB;Mz61Nlgh|ryP M{Pze3NCVkeHUh?=
Capan-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3Lb5BKSzVyPUSuN|I2QDFizszN MljuV2FPT0WU
SW948 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfnTWM2OD12Lke0O|c6KM7:TR?= NYHldYVMW0GQR1XS
HDLM-2 M1z4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2ezS2lEPTB;NT6wO|czPSEQvF2= NFHYTZlUSU6JRWK=
LAN-6 M4rodmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nhdmlEPTB;Nj6yNVQ6PSEQvF2= M4TBSHNCVkeHUh?=
LU-135 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC4TWM2OD14LkSzNFc4KM7:TR?= MnXMV2FPT0WU
T84 M1[xT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jNd2lEPTB;Nj65PFY1KM7:TR?= M1Lxb3NCVkeHUh?=
CAPAN-1 NHzWO|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7kRmc2UUN3ME23MlYzOjN|IN88US=> MV7TRW5ITVJ?
SW1417 MlP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3uVIg{UUN3ME23MlkyPzNzIN88US=> MYXTRW5ITVJ?
BALL-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nTVmlEPTB;OD61NFQxQSEQvF2= MnfoV2FPT0WU
HT-29 M{i2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTlwMEe1PVkh|ryP M1[xT3NCVkeHUh?=
C3A M3jGSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jMdmlEPTB;OT64PFM6PCEQvF2= NV;ze49pW0GQR1XS
NCI-H1993 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjVNpdKSzVyPUGwMlUxQDFizszN M1fzeXNCVkeHUh?=
SK-MEL-1 NYriWXkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFzLk[yPFkh|ryP NHyxVZZUSU6JRWK=
DU-145 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7NWGF1UUN3ME2xOE42ODV{IN88US=> MmDuV2FPT0WU
KP-N-YN M3jhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfRPJRyUUN3ME2xOE42OTB|IN88US=> MnjwV2FPT0WU
CCRF-CEM NEjCTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT0ZnRKSzVyPUG0Mlc5ODlizszN M3LBd3NCVkeHUh?=
ZR-75-30 NHPuNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHhTWM2OD1zNj6zN|A{KM7:TR?= Moi0V2FPT0WU
A673 NY[0[lBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfiTWM2OD1{MD61OVA4KM7:TR?= MWLTRW5ITVJ?
K-562 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzJWnBXUUN3ME2yPE41OTh|IN88US=> MkfFV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

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In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

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  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+PEG300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms NVP-BEZ235

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01856101 Terminated Drug: BEZ235 Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Drug: BEZ235|Drug: Prednisone|Drug: Abiraterone acetate Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01756118 Unknown status Drug: BEZ235 Acute Lymphoblastic Leukemia|Leukemia Myelocytic Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells Johann Wolfgang Goethe University Hospital June 2012 Phase 1
NCT01290406 Withdrawn Drug: BEZ235 Endometrial Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01288092 Withdrawn Drug: BEZ235 Metastatic Breast Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01482156 Completed Drug: RAD001 + BEZ235 Advanced Solid Tumors|Metastatic Breast Cancer|Metastatic Renal Cell Carcinoma Novartis Pharmaceuticals|Novartis January 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID