Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

Size Price Stock Quantity  
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 143 Publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MV\BcpRqdWmlcn;ibYFtKEG|c3H5 NI\aN|EyQCCq MVPEUXNQ MlLLRY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTD3bZRpKEWFNUCgc4YhOC5yMEK1JO69VQ>? NF;yNGozPDhyNUm0Oi=>
MCF7 NEDSU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVSwMlAyNTFyMDFOwG0> MYO0PEBp Mme2SG1UVw>? NXPoR5ZIUUN3ME2wMlc{KM7:TR?= MXOyN|g4OTlyNB?=
HCT116 M3HuSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DKSlAvODFvMUCwJO69VQ>? MX20PEBp M325bGROW09? NHTrdpFKSzVyPUGuNVYh|ryP NXX4NGlYOjN6N{G5NFQ>
U87MG NVraNXBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;vXIcxNjBzLUGwNEDPxE1? NYLOUYJTPDhiaB?= MXnEUXNQ MkLMTWM2OD1zLkOyJO69VQ>? NEDPUXczOzh5MUmwOC=>
HBC4 NFPJVmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXKwMlAyNTFyMDFOwG0> MUG0PEBp MnX0UI9oKEeLNUC9MVgvPjFiTR?= MkPwNlI{OzZ{NE[=
BSY1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVr6VoFzOC5yMT2xNFAh|ryP MWC0PEBp MmPaUI9oKEeLNUC9MVgvPDhiTR?= M{fRZVIzOzN4MkS2
HBC5 NIfOc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[yWG5oOC5yMT2xNFAh|ryP MVG0PEBp NE\Jd3lNd2diR1m1NF0uPy56NzDN MUGyNlM{PjJ2Nh?=
MCF7 M4n3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\XSnAxNjBzLUGwNEDPxE1? NYW2WGkxPDhiaB?= M3TmXWxw\yCJSUWwQU05NjF4IF2= NV63c4FVOjJ|M{[yOFY>
MDA-MB-231 NG\UdJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq4NE4xOS1zMECg{txO NXjzU|JYPDhiaB?= NIDoeIxNd2diR1m1NF0uQC5yOTDN MUeyNlM{PjJ2Nh?=
U251 NVH3fYY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYiwMlAyNTFyMDFOwG0> M3vX[VQ5KGh? M3jl[mxw\yCJSUWwQU04NjZ4IF2= NIP1ZXIzOjN|NkK0Oi=>
SF268 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXKwMlAyNTFyMDFOwG0> MkjhOFghcA>? NXTCVms5VG:pIFfJOVA:NTdwOUKgUS=> NYfE[mxCOjJ|M{[yOFY>
SF295 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV2wMlAyNTFyMDFOwG0> MnvtOFghcA>? MV7Mc4chT0l3ME2tPE4{OSCP MUeyNlM{PjJ2Nh?=
SF539 M3Tz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqwMlAyNTFyMDFOwG0> NETRTpY1QCCq M1LzbWxw\yCJSUWwQU05NjV7IF2= M2LNXFIzOzN4MkS2
SNB75 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXmNE4xOS1zMECg{txO NFvSSlM1QCCq NH\u[5BNd2diR1m1NF0uQC53ODDN MoL5NlI{OzZ{NE[=
SNB78 MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HlbFAvODFvMUCwJO69VQ>? NIm4cHY1QCCq NWHX[Il1VG:pIFfJOVA:NThwNkWgUS=> M2To[|IzOzN4MkS2
HCC2998 NUnINoFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT1NE4xOS1zMECg{txO MmLqOFghcA>? NWHlUldxVG:pIFfJOVA:NThwMEWgUS=> M4G0S|IzOzN4MkS2
KM12 NVvB[HZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVGwMlAyNTFyMDFOwG0> M{DFe|Q5KGh? MXXMc4chT0l3ME2tO{42PCCP MX2yNlM{PjJ2Nh?=
HT-29 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;wc2sxNjBzLUGwNEDPxE1? NHv3bGg1QCCq M{fIPGxw\yCJSUWwQU04Njd3IF2= M3\PcFIzOzN4MkS2
HCT15 NWHxR3NOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjWNE4xOS1zMECg{txO NI[zPZU1QCCq M3XQ[Wxw\yCJSUWwQU05NjB|IF2= NH;5[pgzOjN|NkK0Oi=>
HCT116 NUXHWYNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXSwMlAyNTFyMDFOwG0> NULDSmw5PDhiaB?= M3\3UGxw\yCJSUWwQU04NjZzIF2= Ml;vNlI{OzZ{NE[=
NCI-H23 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\3RlAvODFvMUCwJO69VQ>? NFXBXGM1QCCq NYXrVlhrVG:pIFfJOVA:NTdwNkSgUS=> MljzNlI{OzZ{NE[=
NCI-H226 NWnEXpk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYqwMlAyNTFyMDFOwG0> MYK0PEBp NFL6[HFNd2diR1m1NF0uQC52NDDN Mo\HNlI{OzZ{NE[=
NCI-H522 NIrZT3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\Kfm4xNjBzLUGwNEDPxE1? MVu0PEBp MmnUUI9oKEeLNUC9MVgvPDViTR?= M1;yclIzOzN4MkS2
NCI-H438 NXjlZmtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP0TFExNjBzLUGwNEDPxE1? NHnCTlY1QCCq Mki3UI9oKEeLNUC9MVgvOTFiTR?= M2HzSVIzOzN4MkS2
A549 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jNE4xOS1zMECg{txO NIW1cIQ1QCCq NUC3bnpRVG:pIFfJOVA:NThwMEegUS=> NH2wNHUzOjN|NkK0Oi=>
DMS273 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:wdngxNjBzLUGwNEDPxE1? NWrFfYx7PDhiaB?= NIO0cI5Nd2diR1m1NF0uPy56MDDN M{Xoe|IzOzN4MkS2
DMS114 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPiNE4xOS1zMECg{txO MXe0PEBp MY\Mc4chT0l3ME2tPE4{QSCP MV:yNlM{PjJ2Nh?=
LOXIMVI M33LZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\UWFgxNjBzLUGwNEDPxE1? NIK2TGM1QCCq Mn;GUI9oKEeLNUC9MVgvPjZiTR?= M2\YZlIzOzN4MkS2
OVCAR3 M4LnVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWzO5BmOC5yMT2xNFAh|ryP M2LD[FQ5KGh? Mkn0UI9oKEeLNUC9MVgvOTdiTR?= MnrFNlI{OzZ{NE[=
OVCAR4 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH0NE4xOS1zMECg{txO MmfMOFghcA>? NHizO2ZNd2diR1m1NF0uQC53ODDN M370V|IzOzN4MkS2
OVCAR5 M2S0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjVO|AxNjBzLUGwNEDPxE1? NUP4cJI6PDhiaB?= NYXGS5RUVG:pIFfJOVA:NTdwNUegUS=> MUSyNlM{PjJ2Nh?=
OVCAR8 NF;ybmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\n[nYxNjBzLUGwNEDPxE1? NGX4XVY1QCCq NF3hVHpNd2diR1m1NF0uPy56NDDN M2HBUlIzOzN4MkS2
SKOV3 MnOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr6Vm96OC5yMT2xNFAh|ryP NX36SoY4PDhiaB?= NETrOlRNd2diR1m1NF0uQC52MTDN NUfGVGtmOjJ|M{[yOFY>
RXF631L M2TIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG0NE4xOS1zMECg{txO M1;ndVQ5KGh? MmXVUI9oKEeLNUC9MVgvOjFiTR?= MXSyNlM{PjJ2Nh?=
ACHN MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGwMlAyNTFyMDFOwG0> M{LxTlQ5KGh? NH7TVHBNd2diR1m1NF0uPy57NTDN NVrRbWg3OjJ|M{[yOFY>
St-4 NUm5VpNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;jNE4xOS1zMECg{txO NXL2VndIPDhiaB?= M2DOVGxw\yCJSUWwQU04NjR5IF2= NH:zVFMzOjN|NkK0Oi=>
MKN1 M2DBfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXuwMlAyNTFyMDFOwG0> MkjNOFghcA>? NVO3TJlkVG:pIFfJOVA:NThwNEGgUS=> MWqyNlM{PjJ2Nh?=
MKN7 NGe2e3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnRNE4xOS1zMECg{txO NYXHSoN4PDhiaB?= NX;jRlZZVG:pIFfJOVA:NTdwNkigUS=> MWiyNlM{PjJ2Nh?=
MKN28 M{PuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLqNE4xOS1zMECg{txO Mn7POFghcA>? MWPMc4chT0l3ME2tO{4xPyCP MlfyNlI{OzZ{NE[=
MKN45 M1r4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULqUot4OC5yMT2xNFAh|ryP M2LRWlQ5KGh? M4PjZmxw\yCJSUWwQU05NjN2IF2= M{n5bFIzOzN4MkS2
MKN74 Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLHNGcxOC5yMT2xNFAh|ryP NFLjflc1QCCq NVK2cmh4VG:pIFfJOVA:NTdwNEKgUS=> MV6yNlM{PjJ2Nh?=
DU145 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDINE4xOS1zMECg{txO MlHtOFghcA>? NH75fmtNd2diR1m1NF0uQC5zNjDN M3nhflIzOzN4MkS2
PC3 NWXzbG57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWiwMlAyNTFyMDFOwG0> NH2zWWo1QCCq NH7WXnpNd2diR1m1NF0uQC54NjDN MUGyNlM{PjJ2Nh?=
Trypanosoma brucei brucei Mli2SpVv[3Srb36gRZN{[Xl? NIPpT2IzODBibl2= NWTwdmNxOTJiaB?= NW\vPYQ{TE2VTx?= MYfE[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt NIXLUnozPDhyNUm0Oi=>
Trypanosoma brucei brucei NELTUGZHfW6ldHnvckBCe3OjeR?= M3zhb|E5KGh? M1HvR2ROW09? MWXJcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? M3n4dVI1QDB3OUS2
Trypanosoma brucei brucei M{TBVGZ2dmO2aX;uJGF{e2G7 NXuySHZXOjByIH7N M1OyWFEzKGh? NUHVSGVKTE2VTx?= MWDF[oZm[3Rib36gd5BpcW6pb335cIVqdiCuZY\lcC=> NUHzOVBzOjR6MEW5OFY>
Trypanosoma brucei brucei MU\GeY5kfGmxbjDBd5NigQ>? MUeyNFAhdk1? NX6zPHN{OTJiaB?= NHi0co9FVVOR NF[wc4RG\m[nY4Sgc44heGixc4DoZZRq\HmuY3jvcIlv\SCuZY\lcC=> MkjpNlQ5ODV7NE[=
UM-UC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjpU|VZUUN3ME2zNVUheE1? MVjTRW5ITVJ?
SBC-1 NUXSS2R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vTR2lEPTB;N{SyJJBO MYDTRW5ITVJ?
MKN1 NWXBSJVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTsTWM2OD1{Lkigcm0> NGXtOnhUSU6JRWK=
NCI-H720 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPmfY9KSzVyPUOuOVchdk1? MlTSV2FPT0WU
BFTC-909 NEPDbodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTwTWM2OD1|LkexJI5O NGGxb3dUSU6JRWK=
BPH-1 M2nVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\MTWM2OD12Lke2JI5O MVTTRW5ITVJ?
PC-3 NV:yc2hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq3TWM2OD13LkC5JI5O NUCxNoFqW0GQR1XS
AN3-CA M3TFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYf6WGZ2UUN3ME21MlU3KG6P NH\1W|RUSU6JRWK=
HN NUnY[VhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXR[WNKSzVyPUWuPVYhdk1? NHnyfotUSU6JRWK=
HCC2218 M{TER2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjOb2w1UUN3ME22MlYyKG6P M4T3N3NCVkeHUh?=
KP-4 NFnJRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M123NmlEPTB;NzDuUS=> M1nP[nNCVkeHUh?=
LU-139 MnLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXMTG9IUUN3ME23Mlc4KG6P MVPTRW5ITVJ?
ETK-1 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXLV5d[UUN3ME23Mlg5KG6P NYW1WHRyW0GQR1XS
Ramos-2G6-4C10 M{nJN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRThwNEmgcm0> MUfTRW5ITVJ?
MHH-PREB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HSO2lEPTB;OT6xNkBvVQ>? NFzCWoJUSU6JRWK=
DU-4475 M17Hb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHXTWM2OD17LkS0JI5O MVPTRW5ITVJ?
NCI-H1666 M2T3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzvd4tuUUN3ME25MlcyKG6P M4TncHNCVkeHUh?=
CAMA-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvEbXFKSzVyPUmuPEBvVQ>? M{LtWnNCVkeHUh?=
TYK-nu M3P6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmwTWM2OD17Lkm0JI5O NV7MRVJqW0GQR1XS
MFE-280 NWrtSlJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TQWWlEPTB;OT65PUBvVQ>? M3vJOHNCVkeHUh?=
A549 M2iyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHC[mRKSzVyPUGwMlE1KG6P MWLTRW5ITVJ?
769-P NGO2PZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFyLkS0JI5O MmTMV2FPT0WU
L-363 Ml[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTFyLk[5JI5O Mk\hV2FPT0WU
ES8 NED0UpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvrd3FKSzVyPUGwMlkhdk1? MmDhV2FPT0WU
PA-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XYdGlEPTB;MUGuPFIhdk1? Mn:3V2FPT0WU
Mewo M3XUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\QNHlHUUN3ME2xNU46QSCwTR?= MWLTRW5ITVJ?
HSC-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWmwbFFWUUN3ME2xNk4zOSCwTR?= NFXwe2dUSU6JRWK=
H4 M4q2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXITWM2OD1zMj62O{BvVQ>? MonoV2FPT0WU
BB65-RCC NUXwe5pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYe4W3lYUUN3ME2xNk44OiCwTR?= M3W1dnNCVkeHUh?=
NCI-H1793 MkL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF{LkiyJI5O NWjUV2tCW0GQR1XS
KARPAS-45 NUPZPZhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTF|LkWxJI5O NED5botUSU6JRWK=
GCT M3n4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmm4TWM2OD1zMz62PEBvVQ>? M13UWHNCVkeHUh?=
EoL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7VdHRqUUN3ME2xN{46OyCwTR?= MknsV2FPT0WU
LB2241-RCC M3u1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7q[5k5UUN3ME2xOE4xOSCwTR?= MVvTRW5ITVJ?
ES5 M4nmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fCTGlEPTB;MUSuO|Qhdk1? MoTPV2FPT0WU
LOXIMVI NGW5fnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH0TWM2OD1zND65PUBvVQ>? NV3kR|R5W0GQR1XS
COR-L105 M1\xOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDkU5NMUUN3ME2xOU4xPCCwTR?= NX\zPZBHW0GQR1XS
P12-ICHIKAWA M4nCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nERmlEPTB;MUWuNUBvVQ>? NVv3b|Z7W0GQR1XS
CHL-1 M37BbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X2UGlEPTB;MUWuOFUhdk1? NHfoTohUSU6JRWK=
VMRC-RCZ MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW4d|hsUUN3ME2xOU43OyCwTR?= MnvGV2FPT0WU
HH NIjUNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HyNWlEPTB;MUWuO{BvVQ>? MW\TRW5ITVJ?
NUGC-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLOTWM2OD1zNj6zOEBvVQ>? M2CxfXNCVkeHUh?=
EGI-1 NVrCeXNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjLZZRKSzVyPUG2MlQ{KG6P MlHIV2FPT0WU
OS-RC-2 NV:xb5hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF4LkS3JI5O NXPMZXNbW0GQR1XS
MOLT-16 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfEXW9KSzVyPUG3MlE2KG6P MnnYV2FPT0WU
NCI-H209 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\ud2xKSzVyPUG3MlI6KG6P M4jDUXNCVkeHUh?=
697 MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDGOlBKSzVyPUG3MlQ{KG6P MoLHV2FPT0WU
D-56MG MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHJV5dQUUN3ME2xO{43QSCwTR?= MkC3V2FPT0WU
VA-ES-BJ NHzZcoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LmPWlEPTB;MUeuPFMhdk1? M1rFXnNCVkeHUh?=
EW-16 NWPCdlJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHRdZdKSzVyPUG4MlA1KG6P NF\UbINUSU6JRWK=
HGC-27 NF\mdYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjXfWxGUUN3ME2xPE4xPiCwTR?= MlzEV2FPT0WU
ES7 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF6LkC5JI5O M{TrVHNCVkeHUh?=
HuH-7 NGrPTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPF[oRKSzVyPUG4MlQhdk1? M4DHc3NCVkeHUh?=
BCPAP NVLqdlBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLVbId7UUN3ME2xPE43PSCwTR?= NEDCb4ZUSU6JRWK=
SW1710 MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fSSGlEPTB;MUiuO|Ihdk1? M2DnS3NCVkeHUh?=
IST-MEL1 NWrIVHVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvyeGZKSzVyPUG4Mlc4KG6P Mmj3V2FPT0WU
SF295 NIK1SJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DnS2lEPTB;MUiuPVMhdk1? NFvwRYtUSU6JRWK=
RPMI-7951 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF7LkK4JI5O MVzTRW5ITVJ?
SF126 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LZ[2lEPTB;MUmuOFEhdk1? NW[yRlU1W0GQR1XS
GAMG NHjt[nFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXoeVZKSzVyPUG5MlQ5KG6P MkOzV2FPT0WU
KNS-81-FD MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF7LkW0JI5O NFjiSY9USU6JRWK=
RT-112 Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDOe|V2UUN3ME2xPU43PiCwTR?= MYjTRW5ITVJ?
DEL NULqTplJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzVbFltUUN3ME2yNE41QSCwTR?= M1S1OnNCVkeHUh?=
CGTH-W-1 NXrlNoNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTDTGtIUUN3ME2yNE43OyCwTR?= MYLTRW5ITVJ?
HOS NVfYT2RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJzLkC2JI5O NGTtbZJUSU6JRWK=
ES4 NInnd4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXvZYtiUUN3ME2yNU4xQCCwTR?= NVPHSpprW0GQR1XS
RXF393 NGLifIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnWxTWM2OD1{MT60OUBvVQ>? MkmyV2FPT0WU
NCI-H2030 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJzLkWyJI5O MkfaV2FPT0WU
YH-13 M1GxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13SdWlEPTB;MkGuPFghdk1? NGHrcpFUSU6JRWK=
HT-1080 NHHkSotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3OTWM2OD1{MT65N{BvVQ>? NVHuTHRVW0GQR1XS
NCI-SNU-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfR[nh7UUN3ME2yNU46PSCwTR?= MVzTRW5ITVJ?
G-402 NV\ab2ZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\rTWM2OD1{Mj6xOkBvVQ>? NHzG[pBUSU6JRWK=
786-0 NHvuTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\hNmZTUUN3ME2yNk4zQSCwTR?= MnLnV2FPT0WU
ME-180 NGn5bHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[zdlRuUUN3ME2yNk41OyCwTR?= M3K0cnNCVkeHUh?=
NB69 MnvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M331[GlEPTB;MkKuOVMhdk1? Mlz2V2FPT0WU
J-RT3-T3-5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOwT5o{UUN3ME2yNk46PiCwTR?= NF7adIdUSU6JRWK=
TGBC1TKB MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3VXYcyUUN3ME2yN{4xPSCwTR?= MkHBV2FPT0WU
SW780 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXxZ29KSzVyPUKzMlE{KG6P MXTTRW5ITVJ?
MG-63 M{\mRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCxTWM2OD1{Mz60OUBvVQ>? NVr5d2hDW0GQR1XS
BV-173 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnVTWM2OD1{Mz64O{BvVQ>? NHfW[41USU6JRWK=
CAL-51 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH1Sm1tUUN3ME2yN{45QSCwTR?= NHrqcGNUSU6JRWK=
A375 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJ|LkmzJI5O M2CxSHNCVkeHUh?=
MEL-HO MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC0bmJLUUN3ME2yOE4xPCCwTR?= NH24coJUSU6JRWK=
EFO-27 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGqyN|ZKSzVyPUK0MlM{KG6P NVLESFRuW0GQR1XS
Hs-578-T M4HpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHZTWM2OD1{ND61PEBvVQ>? MV3TRW5ITVJ?
NBsusSR MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MluzTWM2OD1{ND62JI5O M3fhfHNCVkeHUh?=
CTB-1 NHf5PYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXniPJh4UUN3ME2yOE43PyCwTR?= MX\TRW5ITVJ?
FTC-133 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ3LkGgcm0> M4foTHNCVkeHUh?=
MOLT-4 MkewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[2Vm1ZUUN3ME2yOU4yOiCwTR?= MmTSV2FPT0WU
HO-1-N-1 NH[ye3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnmSnprUUN3ME2yOU4yPSCwTR?= NUPqNpBYW0GQR1XS
ES3 M1jCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELYN5lKSzVyPUK1MlIzKG6P M3nlPHNCVkeHUh?=
TI-73 M4nlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C1cGlEPTB;MkWuNlghdk1? M2XGRXNCVkeHUh?=
MPP-89 MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rXNmlEPTB;MkWuN|Ihdk1? NGHmd|JUSU6JRWK=
KYSE-150 Ml\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ3Lki5JI5O NFHwdIJUSU6JRWK=
LXF-289 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvYS5h3UUN3ME2yOk4xPCCwTR?= MmjSV2FPT0WU
SK-LU-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3KTWM2OD1{Nj6xO{BvVQ>? NX;FdHNzW0GQR1XS
HOP-92 MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH5TWM2OD1{Nj60PEBvVQ>? MY\TRW5ITVJ?
HuO9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC2TWM2OD1{Nj63OkBvVQ>? Mo\xV2FPT0WU
SW962 NYXINHloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJ4Lke2JI5O NX7CcXdSW0GQR1XS
RS4-11 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7vUpVlUUN3ME2yOk46OSCwTR?= MVHTRW5ITVJ?
NCI-H292 M2S0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{O5WmlEPTB;Mkegcm0> MkfHV2FPT0WU
DB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17PbGlEPTB;MkeuN|Yhdk1? NFn2PY1USU6JRWK=
SW1088 Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJ6LkK5JI5O NXjueVZKW0GQR1XS
A204 M{D6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJ6LkS3JI5O MYDTRW5ITVJ?
A3-KAW M{\2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ6Lk[0JI5O NHnUSotUSU6JRWK=
MV-4-11 M1LWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7LTWM2OD1{OD63JI5O NHy1SllUSU6JRWK=
ES1 NWjpO49YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{G5SmlEPTB;MkiuPFQhdk1? MXrTRW5ITVJ?
ONS-76 NF34T3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fYSWlEPTB;MkmuNFUhdk1? MlHHV2FPT0WU
D-263MG NVXFUmdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTJ7LkO1JI5O NGXmdXNUSU6JRWK=
U-2-OS M3;oO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDqTWM2OD1{OT61JI5O M1XHWnNCVkeHUh?=
T98G M1fHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPXUplKSzVyPUK5Mlg5KG6P MnPaV2FPT0WU
GI-ME-N NWDTTVl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPX[m5KSzVyPUK5MlkyKG6P NHHFV4NUSU6JRWK=
BHT-101 NWHLZWJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnpZVJKSzVyPUOwMlA2KG6P M4PRSXNCVkeHUh?=
NOS-1 M3nRe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojJTWM2OD1|MD6xNkBvVQ>? M4nWNHNCVkeHUh?=
AsPC-1 M2C5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XTZ2lEPTB;M{CuNkBvVQ>? NIGxW2JUSU6JRWK=
QIMR-WIL M3THfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTNyLk[gcm0> NV:zPWNuW0GQR1XS
JVM-3 M1\F[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrmbINKSzVyPUOwMlg{KG6P MX7TRW5ITVJ?
KU-19-19 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrCfGxKSzVyPUOxMlE{KG6P NWTMdXhDW0GQR1XS
OVCAR-8 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq3W5pHUUN3ME2zNU4zPiCwTR?= MYHTRW5ITVJ?
BEN MlTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\ZeFA3UUN3ME2zNU43OyCwTR?= NELhbpVUSU6JRWK=
BE-13 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X3UWlEPTB;M{GuPFIhdk1? M{LaVXNCVkeHUh?=
EW-18 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXhfYhKSzVyPUOxMlg3KG6P M1flZXNCVkeHUh?=
ECC10 MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv4e5ZQUUN3ME2zNU46PSCwTR?= M2fMS3NCVkeHUh?=
CTV-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTN{LkiyJI5O NHjXUYFUSU6JRWK=
COLO-800 M{XsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqxN5ZKSzVyPUOyMlkzKG6P MkHQV2FPT0WU
A2058 NGDOXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUe3bpM1UUN3ME2zN{4zPSCwTR?= Mk\xV2FPT0WU
VM-CUB-1 NX;xfXJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr1W3A4UUN3ME2zN{41OyCwTR?= Mmq5V2FPT0WU
Ca9-22 MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\kTWM2OD1|Mz61OUBvVQ>? MXvTRW5ITVJ?
COLO-684 NUPwWpZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zrWmlEPTB;M{OuOVghdk1? M{DVVXNCVkeHUh?=
RPMI-8226 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLzfXdYUUN3ME2zN{45OiCwTR?= M1zXVnNCVkeHUh?=
SK-NEP-1 M1\4dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW4PYJFUUN3ME2zOE4yPSCwTR?= MonGV2FPT0WU
Becker Mn7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDjTWM2OD1|ND6yNUBvVQ>? M1jhc3NCVkeHUh?=
NCI-H28 NUTpRopOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr4c4FKSzVyPUO0MlQ1KG6P NYWzeZRyW0GQR1XS
CAL-120 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M36xOWlEPTB;M{SuO|Ihdk1? M{LrXXNCVkeHUh?=
MDA-MB-157 NEPqU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD6R3BEUUN3ME2zOU41OSCwTR?= MULTRW5ITVJ?
OVCAR-5 MoXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjKd5pKSzVyPUO1MlQ4KG6P MXXTRW5ITVJ?
LAMA-84 NXOwPGI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rGUGlEPTB;M{WuPFchdk1? NYG3XXFpW0GQR1XS
CAKI-1 MmrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzTTWM2OD1|Nj60N{BvVQ>? MoTQV2FPT0WU
Daoy MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K0dWlEPTB;M{[uO{BvVQ>? M3PPUHNCVkeHUh?=
CAL-62 Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTRdYtQUUN3ME2zOk45PiCwTR?= MnjuV2FPT0WU
8-MG-BA NGTWZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7JTWM2OD1|Nz6yOUBvVQ>? MVjTRW5ITVJ?
8505C NI\KOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XvS2lEPTB;M{euOVEhdk1? MlrjV2FPT0WU
LNCaP-Clone-FGC NXvHVG1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIO3S3dKSzVyPUO3MlU6KG6P NHjuN4RUSU6JRWK=
CAL-39 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKzdGhKUUN3ME2zO{46KG6P MWDTRW5ITVJ?
MN-60 NXPBd4RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7BN45KSzVyPUO3Mlk3KG6P NWHMfpVsW0GQR1XS
RKO NWH5NHRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTN6LkOzJI5O NFGyO|lUSU6JRWK=
U251 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;5fWlEPTB;M{iuOFMhdk1? M2jjVXNCVkeHUh?=
SJSA-1 NH:0S3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTN6LkW0JI5O MorwV2FPT0WU
CAL-12T NUfDbJl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv0TWM2OD1|OD62JI5O M4X6PHNCVkeHUh?=
HCC1419 NXK4RmRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rpemlEPTB;M{iuO|Ehdk1? MlfXV2FPT0WU
CO-314 NFTlTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTLRYpyUUN3ME2zPE44PCCwTR?= NHvmeo9USU6JRWK=
LB1047-RCC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\yXXRKSzVyPUO4MlgyKG6P NFTqeWJUSU6JRWK=
A101D NXHydo1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXCTWM2OD1|OD65O{BvVQ>? M2W5ZXNCVkeHUh?=
MDA-MB-175-VII M37LZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLrOJh4UUN3ME2zPU42OSCwTR?= Mm\2V2FPT0WU
MZ2-MEL M1TVOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLMTWM2OD1|OT62OkBvVQ>? Ml;zV2FPT0WU
NB5 M{PQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC5[IFKSzVyPUSwMlY1KG6P NY\RXWFXW0GQR1XS
G-401 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHIT3NKSzVyPUSwMlgzKG6P NHLsdpdUSU6JRWK=
HT MoXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MortTWM2OD12MT6wNkBvVQ>? NXz6eHg5W0GQR1XS
8305C M2DoUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH64bXBKSzVyPUSxMlg4KG6P M2r4cnNCVkeHUh?=
BHY MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHyTWM2OD12Mj63NkBvVQ>? NW\ld3pTW0GQR1XS
NTERA-S-cl-D1 M3nnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTBTWM2OD12MzDuUS=> MV3TRW5ITVJ?
T-24 NU\ld2psT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPWOIZKSzVyPUSzMlg{KG6P NUTmbnB4W0GQR1XS
EPLC-272H NWDYUVIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHZe|dWUUN3ME20OE4{QSCwTR?= NXPwWmU2W0GQR1XS
PSN1 NYfhdmNqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvrTWM2OD12ND60JI5O MVnTRW5ITVJ?
NCI-H2452 M4jV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPQTWM2OD12ND61PEBvVQ>? NFHCUFRUSU6JRWK=
KS-1 NXLFbFVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCwTYU{UUN3ME20OE43PiCwTR?= M{nZ[HNCVkeHUh?=
HD-MY-Z MmW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTR2LkmyJI5O NUHRUXd1W0GQR1XS
KNS-62 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO3TWM2OD12NT6zPEBvVQ>? M2\LWnNCVkeHUh?=
NOMO-1 NUHtdZR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjETXlqUUN3ME20OU45PyCwTR?= NYPGR25wW0GQR1XS
SK-HEP-1 MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{mwXGlEPTB;NE[uNFQhdk1? Mlm2V2FPT0WU
IGR-1 NIK4T2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTR4LkGzJI5O M1;obHNCVkeHUh?=
KYSE-180 M3\yWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7FNFBKSzVyPUS2MlE4KG6P NETY[mdUSU6JRWK=
EW-22 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHSyWo1KSzVyPUS2MlIhdk1? NH3hcIRUSU6JRWK=
NCI-H1355 M{jUW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljsTWM2OD12Nj6zOEBvVQ>? MVHTRW5ITVJ?
DOHH-2 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\0TWM2OD12Nj6zO{BvVQ>? MU\TRW5ITVJ?
A4-Fuk NEDhZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLlTWM2OD12Nj61NkBvVQ>? NYTMbVFuW0GQR1XS
PC-14 NVS5PJJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTR4LkW3JI5O M2j0XXNCVkeHUh?=
TE-5 NX[ySndzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTR4Lki0JI5O NGK5VFlUSU6JRWK=
LB996-RCC NWfTSpVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O2dWlEPTB;NEeuNVkhdk1? MXjTRW5ITVJ?
NCI-H1623 MmTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTR5Lke2JI5O NV3aVnVpW0GQR1XS
NCI-H1155 NEjkU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL6OItKSzVyPUS4MlMzKG6P NUXXNYxMW0GQR1XS
LoVo MoXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTR6LkSgcm0> NFLXUoZUSU6JRWK=
MCF7 NGfNd3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\K[mZKSzVyPUS4MlU5KG6P MXTTRW5ITVJ?
AGS NGTLXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3u2SmlEPTB;NEiuO|chdk1? MkXjV2FPT0WU
PFSK-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTR7LkC2JI5O M{fzNnNCVkeHUh?=
22RV1 NW\p[m5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzwWXNKSzVyPUS5MlA6KG6P M1\sOXNCVkeHUh?=
COR-L23 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTOTWM2OD12OT6xOkBvVQ>? NIq1RYhUSU6JRWK=
D-283MED MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLnPJVKSzVyPUS5MlYyKG6P NVraWZRSW0GQR1XS
SW982 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\4PZBMUUN3ME20PU46OSCwTR?= NFzOVpJUSU6JRWK=
SW620 MmLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTVyLkO2JI5O MmPjV2FPT0WU
KYSE-140 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\PXpVKSzVyPUWwMlU2KG6P M2i0bHNCVkeHUh?=
GCIY MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHu1RoRKSzVyPUWwMlY4KG6P MXPTRW5ITVJ?
MHH-ESS-1 M3KxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDVHVKSzVyPUWxMlk2KG6P NHzlUmhUSU6JRWK=
D-423MG MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnhTWM2OD13Mj6wPEBvVQ>? MX3TRW5ITVJ?
SF539 MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrXS4VKSzVyPUWyMlM2KG6P M{\xc3NCVkeHUh?=
RPMI-2650 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3sRmpKSzVyPUWyMlY6KG6P MnW4V2FPT0WU
GR-ST NITz[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfWS|l2UUN3ME21Nk45PyCwTR?= MlfmV2FPT0WU
YKG-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvUTVdIUUN3ME21N{BvVQ>? MU\TRW5ITVJ?
SK-MES-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTV|LkK2JI5O NYThRmJVW0GQR1XS
HLE MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\FTXFKSzVyPUWzMlQ4KG6P M{DFSHNCVkeHUh?=
RVH-421 M{mzcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4ixS2lEPTB;NUOuOlchdk1? M3TkRXNCVkeHUh?=
C32 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPvTXhKSzVyPUWzMlg{KG6P NUPITYNTW0GQR1XS
GB-1 Mm\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTV2LkKgcm0> NX;URVFGW0GQR1XS
SNB75 NV:2SFVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHOeJpoUUN3ME21OE4zPiCwTR?= NX25boFYW0GQR1XS
EM-2 M4H4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\yTWM2OD13ND60JI5O M1zCNnNCVkeHUh?=
RH-1 M3jSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3L3bmlEPTB;NUSuO{BvVQ>? MmPRV2FPT0WU
NKM-1 NFv6[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TBd2lEPTB;NUSuPFEhdk1? NXHI[pc2W0GQR1XS
NCI-H2405 NITjb2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX2TWM2OD13ND64PEBvVQ>? MlPOV2FPT0WU
KYSE-450 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXaTWM2OD13NT6xOkBvVQ>? M1zOSHNCVkeHUh?=
A704 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTV3LkW5JI5O NW\FO4I{W0GQR1XS
HAL-01 NUnWXHRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\5UWlEPTB;NUWuPFMhdk1? M3:2OHNCVkeHUh?=
TE-11 NYGwN|hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf2W|RKSzVyPUW1Mlk6KG6P NH\1b21USU6JRWK=
DOK NV7HSlh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHNU|J4UUN3ME21Ok4xOiCwTR?= Ml3pV2FPT0WU
KY821 NEL2ZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfVSGw4UUN3ME21Ok4zKG6P MVjTRW5ITVJ?
KGN MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTV4LkOyJI5O MVHTRW5ITVJ?
MC116 NEO5VWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLDTWM2OD13Nz64JI5O MlywV2FPT0WU
PANC-08-13 M3r1O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTV6LkCxJI5O MWHTRW5ITVJ?
KE-37 NI\5N|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPmeW9xUUN3ME21PE44PyCwTR?= MXjTRW5ITVJ?
KYSE-410 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\kOIo2UUN3ME21PU41PyCwTR?= NXTzUXVwW0GQR1XS
RO82-W-1 M{j1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfWTWM2OD13OT65JI5O M4Tr[nNCVkeHUh?=
M14 NVW1[XhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTZyLkC0JI5O NHjCd25USU6JRWK=
GI-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTZyLkOgcm0> M2LocXNCVkeHUh?=
ML-2 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fhSWlEPTB;NkCuOlIhdk1? NW\xbYs5W0GQR1XS
BFTC-905 NVS1OJpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXiZpdKSzVyPU[wMlY2KG6P NHnPPVhUSU6JRWK=
DMS-273 NXmxOZBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP6R4lKSzVyPU[wMlg4KG6P M2rDN3NCVkeHUh?=
MDA-MB-361 NWXlR5o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknHTWM2OD14MTDuUS=> M4Tue3NCVkeHUh?=
MSTO-211H MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTCNVVwUUN3ME22N{42OSCwTR?= MnrDV2FPT0WU
MEG-01 NGXicIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfGdpRmUUN3ME22N{42OiCwTR?= MUjTRW5ITVJ?
M059J MoDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTZ|LkW4JI5O MoD2V2FPT0WU
LN-405 NXfVS|VlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTZ|Lki1JI5O Mn;wV2FPT0WU
NCI-H1581 M4HG[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTZ2LkCzJI5O MnLyV2FPT0WU
TCCSUP NVnRdZUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljUTWM2OD14ND61N{BvVQ>? Moi1V2FPT0WU
SW872 Mnf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLQRVJSUUN3ME22OE42PyCwTR?= NXvVc3JzW0GQR1XS
KYSE-510 NHG4Nm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\GTm1KSzVyPU[1Mlc2KG6P MV7TRW5ITVJ?
NCI-H1792 M1nWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W1SWlEPTB;Nk[uNVUhdk1? MVPTRW5ITVJ?
SW13 NGnH[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33YUWlEPTB;Nk[uOUBvVQ>? MoLMV2FPT0WU
TE-8 NHvlS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTZ4LkWyJI5O Mnj4V2FPT0WU
SCH NEDGWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ixbmlEPTB;NkeuNUBvVQ>? MXnTRW5ITVJ?
NEC8 M2flN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPxSlBoUUN3ME22O{4zPCCwTR?= M1n5cXNCVkeHUh?=
HuO-3N1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzpOmFKSzVyPU[3MlMyKG6P NX;sOYJDW0GQR1XS
EFM-19 NFTBPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn6xTWM2OD14Nz61JI5O NGnuendUSU6JRWK=
HEC-1 M{fsc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3PWGNKSzVyPU[3MlUzKG6P MoX4V2FPT0WU
T47D NX7XfVJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTZ5Lki3JI5O MV7TRW5ITVJ?
SNU-423 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTZ5Lkm4JI5O MknxV2FPT0WU
WM-115 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HjSmlEPTB;NkiuNVQhdk1? NX:1NoY2W0GQR1XS
CaR-1 M1;UeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULtbndYUUN3ME22PE4zPSCwTR?= M{HHZXNCVkeHUh?=
KU812 NXHuXZd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILRNmhKSzVyPU[4MlY6KG6P NYjmTVN1W0GQR1XS
AM-38 M{GySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTZ7LkOxJI5O NUmyc5NVW0GQR1XS
KOSC-2 M2\Remdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTZ7Lkm3JI5O MlXPV2FPT0WU
MC-IXC NWG5RVZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvpTWM2OD15MD6wPEBvVQ>? M{jTcnNCVkeHUh?=
SCC-4 NVrT[lBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\pfWlEPTB;N{GuN|ghdk1? NXv4bppyW0GQR1XS
Calu-3 NVraeGNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu0NJd{UUN3ME23NU46QCCwTR?= NX3keY1xW0GQR1XS
RPMI-8866 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTd{LkiyJI5O MYDTRW5ITVJ?
OVCAR-4 M2fXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLje3hKSzVyPUezMlM3KG6P NHjxb4pUSU6JRWK=
OAW-42 M3;NNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f4V2lEPTB;N{OuN|khdk1? NE\tdYRUSU6JRWK=
ATN-1 NUOxZ5UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\ObmJ4UUN3ME23N{45PyCwTR?= NESyOphUSU6JRWK=
CHP-212 NGK5WJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTaTWM2OD15ND65OUBvVQ>? M1HLTXNCVkeHUh?=
C2BBe1 MkLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfMOnRQUUN3ME23OU4xOyCwTR?= M3r2dnNCVkeHUh?=
A498 M1vyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjmWnpuUUN3ME23OU4yPSCwTR?= MYHTRW5ITVJ?
SH-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnWWoJKSzVyPUe1MlIyKG6P NYXRVXRSW0GQR1XS
SNU-449 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7KTWM2OD15NT63PUBvVQ>? Ml;pV2FPT0WU
RD NVnLcYVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3noc2lEPTB;N{WuPFYhdk1? MnnQV2FPT0WU
PANC-03-27 NVLVXWVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XDTGlEPTB;N{[uNlUhdk1? NEf4SGZUSU6JRWK=
S-117 NEDRUZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrHcFQzUUN3ME23Ok4zPyCwTR?= NHr2cnhUSU6JRWK=
SK-MEL-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvUOIpKSzVyPUe2Mlc2KG6P MUHTRW5ITVJ?
LK-2 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPrTWM2OD15Nz6wOUBvVQ>? NHrNZYpUSU6JRWK=
CP50-MEL-B MkS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXKcW85UUN3ME23O{41KG6P MnnPV2FPT0WU
647-V M2jNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XmdGlEPTB;N{iuNFchdk1? NVq0VGlKW0GQR1XS
LU-134-A NUnwTWFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWj6foNuUUN3ME23PU4xOyCwTR?= NWLWOmpFW0GQR1XS
5637 NX7jZY9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHzNWZXUUN3ME23PU4zOyCwTR?= MnqyV2FPT0WU
NCI-H1437 MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LqWmlEPTB;OECuOUBvVQ>? M4roc3NCVkeHUh?=
NCI-H460 M4iyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjHcIpKSzVyPUixMlI{KG6P Mn2xV2FPT0WU
BxPC-3 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHJN2NKSzVyPUixMlQ3KG6P Mn2yV2FPT0WU
CAN NYq2c|BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPqTWM2OD16MT64OEBvVQ>? NX;Ic4sxW0GQR1XS
KINGS-1 MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTjTWM2OD16Mj6zNkBvVQ>? NFf1NGFUSU6JRWK=
OCUB-M NIHaXm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2X3NmlEPTB;OEKuOFEhdk1? MkPPV2FPT0WU
KALS-1 NEO5fIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[3bXlPUUN3ME24Nk42PCCwTR?= Mn7JV2FPT0WU
OCI-AML2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LkNWlEPTB;OEKuOlEhdk1? NE\oR5FUSU6JRWK=
A253 NFrj[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\ZOmhKSzVyPUiyMlY2KG6P MVrTRW5ITVJ?
LCLC-97TM1 NFi5ZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jCTmlEPTB;OEKuPFYhdk1? NIi5RZJUSU6JRWK=
NCI-H520 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj3cFNKSzVyPUizMlA3KG6P MXvTRW5ITVJ?
P30-OHK M3nMbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTh|LkWgcm0> MlXRV2FPT0WU
SBC-5 MnzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW2T3RKSzVyPUizMlUzKG6P MYDTRW5ITVJ?
HCE-T NFvJ[VlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTh|Lke0JI5O MVTTRW5ITVJ?
JEG-3 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofxTWM2OD16ND6xJI5O MUPTRW5ITVJ?
KG-1 NWfzbnJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLPVHBnUUN3ME24OE4zPCCwTR?= MYTTRW5ITVJ?
MIA-PaCa-2 M4PO[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3WxdWlEPTB;OESuOVQhdk1? MkTaV2FPT0WU
CAL-33 NWexVGJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHscnhTUUN3ME24OU4xQCCwTR?= MXPTRW5ITVJ?
639-V NYfGUYdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTNbJZKSzVyPUi1MlQzKG6P M3T3fnNCVkeHUh?=
NCI-H1048 NWW1cFR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LVZmlEPTB;OE[uN|Ehdk1? NYS1[JZlW0GQR1XS
NCI-H1573 NHKzT|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIW0WHpKSzVyPUi3MlQ5KG6P NILjcnZUSU6JRWK=
NCI-H2228 NUTrPYZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7uNWdKSzVyPUi4MlI3KG6P M2HCcHNCVkeHUh?=
NB14 Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIiwT3lKSzVyPUi4MlMhdk1? MnfTV2FPT0WU
SCC-25 NVTseVhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTh7LkiyJI5O NIixXndUSU6JRWK=
A431 M1zrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\Ob2V3UUN3ME24PU46PyCwTR?= NHLBUoVUSU6JRWK=
SN12C NVTo[oxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGj1ZYZKSzVyPUmwMlYzKG6P MnrhV2FPT0WU
HuCCT1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTlyLke2JI5O M{XwTHNCVkeHUh?=
LS-123 NYno[XVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzCTWM2OD17Mj6xPEBvVQ>? M{DP[HNCVkeHUh?=
CAL-85-1 M13Fbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPLWmpYUUN3ME25Nk41QCCwTR?= NHLuZ3pUSU6JRWK=
ES6 NI\CfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDXTWM2OD17Mj64N{BvVQ>? NGDEdnZUSU6JRWK=
NCI-H650 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjac3lKSzVyPUm0MlA6KG6P MkTJV2FPT0WU
NCI-H446 NH3YbIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFriSIpKSzVyPUm1MlEzKG6P NEHOV3pUSU6JRWK=
EW-13 M1vNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\kNWtMUUN3ME25OU44PSCwTR?= MX7TRW5ITVJ?
HSC-2 MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3K5T2lEPTB;OUWuPFkhdk1? M3vTWnNCVkeHUh?=
U031 M171Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PQWGlEPTB;OU[uO|Mhdk1? NEfOWmtUSU6JRWK=
EW-11 NHfBOXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHnRmxHUUN3ME25Ok45QCCwTR?= MlP6V2FPT0WU
GAK MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDjTWM2OD17OD65N{BvVQ>? MX;TRW5ITVJ?
SK-OV-3 M1n6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:4ZY91UUN3ME2xNFAvODdibl2= MlfPV2FPT0WU
OMC-1 M3P6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTFyMD6xPEBvVQ>? NILFWIdUSU6JRWK=
TK10 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETNU2xKSzVyPUGwNE4zOSCwTR?= NVPGU4tRW0GQR1XS
EKVX NFrOcY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFyMD62JI5O MVzTRW5ITVJ?
Detroit562 NUXscG9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXIXm5KSzVyPUGwNk4yPyCwTR?= Mo\FV2FPT0WU
SF268 Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFyMj6zOEBvVQ>? NXTaN5FvW0GQR1XS
SNU-387 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLSTWM2OD1zMESuNVchdk1? MUfTRW5ITVJ?
MDA-MB-231 NF\T[VRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPZSlZKSzVyPUGwOU4xPiCwTR?= NIq2bVdUSU6JRWK=
NCI-H1563 M2WxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliwTWM2OD1zMEWuNVghdk1? NVrMTnNpW0GQR1XS
D-502MG M4W5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXiVVNKSzVyPUGwOU44KG6P M17BU3NCVkeHUh?=
A2780 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HWPWlEPTB;MUC2MlQ4KG6P M4TpO3NCVkeHUh?=
IA-LM MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHQTWM2OD1zMEeuOVEhdk1? M2ToeXNCVkeHUh?=
D-392MG NUnqbHdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLpTWM2OD1zMEeuOVQhdk1? NYnZWZVrW0GQR1XS
MS-1 M1HtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz1TWM2OD1zMEeuO|Ehdk1? MkLkV2FPT0WU
SW1990 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHEXpdKSzVyPUGwPE42PCCwTR?= NIn6bYhUSU6JRWK=
HEL NXe3TYZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;yN3dKSzVyPUGwPU4zQSCwTR?= NHTBToFUSU6JRWK=
SW1573 NVS4RpVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS1W2RrUUN3ME2xNFkvOzFibl2= NH\WUmhUSU6JRWK=
SW1783 M4rJNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;rWWlEPTB;MUGwMlIzKG6P M2rUcXNCVkeHUh?=
COLO-680N NELYNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFzMD63OkBvVQ>? MXnTRW5ITVJ?
NCI-N87 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTFzMT6wOEBvVQ>? NV;1fZdoW0GQR1XS
SK-MEL-28 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTFzMT61OUBvVQ>? MoPXV2FPT0WU
BT-20 NH3XenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ZfHdKSzVyPUGxNk4xOSCwTR?= MmTPV2FPT0WU
NCI-H1648 NVXPe2t6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrkUHYyUUN3ME2xNVMhdk1? NHPYbVlUSU6JRWK=
no-11 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fubWlEPTB;MUGzMlI5KG6P NHjCcmNUSU6JRWK=
MOLT-13 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\rTWM2OD1zMUOuOFQhdk1? MmqzV2FPT0WU
NCI-H2170 NX;1U5FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnEcYtKSzVyPUGxOE42OSCwTR?= MojDV2FPT0WU
HTC-C3 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDzTnYzUUN3ME2xNVYvQDVibl2= NFHYb5lUSU6JRWK=
LU-99A M2f0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3SUVRRUUN3ME2xNVcvOjFibl2= NIjifYtUSU6JRWK=
HCC2998 NEHR[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HCZWlEPTB;MUG3MlkzKG6P NVfWU2lWW0GQR1XS
NB13 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH2Z4FKSzVyPUGxO{46QSCwTR?= NGLmUFRUSU6JRWK=
GT3TKB MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO4UFNKSzVyPUGxPE4xQCCwTR?= MmDUV2FPT0WU
BT-549 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ryUWlEPTB;MUG4Mlk2KG6P MVTTRW5ITVJ?
NCI-H747 MofLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi1cVNKSzVyPUGxPU4{PCCwTR?= MVTTRW5ITVJ?
EW-1 M1noPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoCzTWM2OD1zMkCuNkBvVQ>? M1rWOHNCVkeHUh?=
LB831-BLC MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PwSWlEPTB;MUKwMlY{KG6P NFmybJNUSU6JRWK=
NMC-G1 M2P6TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17mWGlEPTB;MUKxMlEyKG6P MYDTRW5ITVJ?
COLO-679 M1Ppc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILIU3lKSzVyPUGyNk4yPSCwTR?= M3PUNHNCVkeHUh?=
HL-60 NWDCXXlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHKR5dKSzVyPUGyN{4yKG6P NHXuW3VUSU6JRWK=
MKN7 NUDP[ox4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7DW|kxUUN3ME2xNlMvQDNibl2= M1HzZXNCVkeHUh?=
RERF-LC-MS NHjTOGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETVZZBKSzVyPUGyOE4{OSCwTR?= MlzOV2FPT0WU
DMS-114 M2TJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\hNVA4UUN3ME2xNlUvODlibl2= NHy4SFRUSU6JRWK=
HuP-T4 M1PUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LCU2lEPTB;MUK2Mlk4KG6P M4HXU3NCVkeHUh?=
HCC2157 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTF{Nz61JI5O M{Dr[nNCVkeHUh?=
SKG-IIIa MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\RV2lEPTB;MUK4Mlghdk1? NG\INJlUSU6JRWK=
HCT-116 NH7LUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW0dVFKSzVyPUGzNE43PCCwTR?= MWnTRW5ITVJ?
BB30-HNC M3Wzbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHZNnVKSzVyPUGzNE44QCCwTR?= MVTTRW5ITVJ?
KYSE-270 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXhTlVwUUN3ME2xN|AvQDhibl2= M4TpTXNCVkeHUh?=
MFM-223 NV3tOZBnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLtZo1KSzVyPUGzNU42OSCwTR?= MUHTRW5ITVJ?
NH-12 M1HtSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPQfFJnUUN3ME2xN|IvQTlibl2= M{\6XHNCVkeHUh?=
U-118-MG NHPkOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXzTWM2OD1zM{OuOlIhdk1? NXf0TFFOW0GQR1XS
ESS-1 NIPqRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;oNoFoUUN3ME2xN|UvOThibl2= MVTTRW5ITVJ?
D-247MG NYTYOHV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzYW3N3UUN3ME2xN|UvOjFibl2= NF\TS2ZUSU6JRWK=
IGROV-1 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF|NT63OkBvVQ>? MlrtV2FPT0WU
C-33-A MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17BOWlEPTB;MUO1Mlk4KG6P MmW2V2FPT0WU
NCI-H1693 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LjTGlEPTB;MUO2MlEzKG6P MWTTRW5ITVJ?
MLMA M4nhXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP1TWM2OD1zM{[uOVghdk1? NHHuV5NUSU6JRWK=
SK-N-AS NILQ[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTF|Nz6xO{BvVQ>? M{jPUXNCVkeHUh?=
NCI-H1755 Mli3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF|OD64OUBvVQ>? NGPOSYtUSU6JRWK=
CHP-134 MoTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXuPHVsUUN3ME2xN|kvPTVibl2= M2q1dHNCVkeHUh?=
LS-513 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\VVmlEPTB;MUSwMlkyKHCP MlzwV2FPT0WU
TE-12 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIT4fpVKSzVyPUG0NE46OyCwTR?= M1LVfHNCVkeHUh?=
KNS-42 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHWXnpsUUN3ME2xOFQvOyCwTR?= MWfTRW5ITVJ?
SJRH30 NIrqS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\LTWM2OD1zNESuOFQhdk1? NXPsXJpRW0GQR1XS
NCI-H1092 NHLKVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXle3prUUN3ME2xOFQvPTJibl2= M1XQcnNCVkeHUh?=
H-EMC-SS MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfjTWM2OD1zNE[uPFEhdk1? NID3WnRUSU6JRWK=
SK-MEL-3 Mlf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\0XmlEPTB;MUS3MlU2KG6P MUXTRW5ITVJ?
SK-N-FI NUWwdYFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jRSWlEPTB;MUS3MlU6KG6P NX7BZYVYW0GQR1XS
NCI-H2126 NXfsT3liT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDqfnZ2UUN3ME2xOFgvOTVibl2= NXvT[pRWW0GQR1XS
NCI-H1299 NHHjfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXTelhKSzVyPUG1NE4zOiCwTR?= M4TjcnNCVkeHUh?=
CFPAC-1 NInG[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PpVmlEPTB;MUWwMlY3KG6P NITn[opUSU6JRWK=
NCI-H661 MoHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzKZ41KSzVyPUG1NU4zPiCwTR?= NHTZW4lUSU6JRWK=
KYSE-70 NF;LNZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF3MT63PUBvVQ>? NGjn[3RUSU6JRWK=
SW900 NXrFeVBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF3ND62OUBvVQ>? Mn7qV2FPT0WU
Ca-Ski Ml2xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjlbIlKSzVyPUG1Ok4{QSCwTR?= NW\rTpBkW0GQR1XS
HPAF-II NX;ZWFc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXIeXl4UUN3ME2xOVYvPDdibl2= M1jkdnNCVkeHUh?=
LB2518-MEL MoWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHYTWM2OD1zNUeuNUBvVQ>? Mk\rV2FPT0WU
LC-2-ad MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjITWM2OD1zNUiuOlIhdk1? MX3TRW5ITVJ?
HCC1806 NFzPe25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HoU2lEPTB;MU[3Mlg5KG6P NFW0[5hUSU6JRWK=
UACC-62 NGrWV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;ZVYVqUUN3ME2xOlgvODlibl2= MWjTRW5ITVJ?
KM-H2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF5MD61PEBvVQ>? NYXrdY5sW0GQR1XS
NCI-H2347 M{\sOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3kcVhiUUN3ME2xO|IvPzJibl2= MVzTRW5ITVJ?
SCC-15 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF5Mz62OkBvVQ>? MXPTRW5ITVJ?
BB49-HNC NF:0UVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3KTWM2OD1zN{OuPFEhdk1? MlvJV2FPT0WU
GMS-10 NIf6PYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fqdGlEPTB;MUezMlk1KG6P MWLTRW5ITVJ?
NCI-H2052 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF5ND65JI5O M4e3NXNCVkeHUh?=
SW626 NFjyZXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljJTWM2OD1zN{[uNFYhdk1? M3rBS3NCVkeHUh?=
MDA-MB-415 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4i4ZWlEPTB;MUe2MlYyKG6P MkDlV2FPT0WU
Saos-2 NXLPV5BbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X1O2lEPTB;MUe5MlM2KG6P NFO0VYNUSU6JRWK=
DK-MG NUjNUGc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzHXJNKSzVyPUG4NE4{KG6P MYHTRW5ITVJ?
SNU-C2B MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXw[|VSUUN3ME2xPFAvPzNibl2= MkK4V2FPT0WU
A427 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi2W|hDUUN3ME2xPFIvPTdibl2= M2PkenNCVkeHUh?=
KP-N-YS NYL5OZl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLkdo5KSzVyPUG4OUBvVQ>? M3fZXHNCVkeHUh?=
J82 MoT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi0ZohKSzVyPUG4OU4yQCCwTR?= NXfnNlJsW0GQR1XS
LS-411N NI\KOHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHWTWM2OD1zOEeuNlghdk1? NWrRTmlHW0GQR1XS
HCC1937 M2DmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33HPWlEPTB;MUi3MlQ6KG6P NUS0N3g2W0GQR1XS
OE33 M2\mVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrmbllSUUN3ME2xPFgvQTdibl2= NXjLWGtzW0GQR1XS
NB7 MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLzSHFKSzVyPUG4PU45QSCwTR?= MYPTRW5ITVJ?
SW684 NUSxPIRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vqbmlEPTB;MUm2MlE{KG6P Mn\MV2FPT0WU
HT-144 M2jHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\YW29vUUN3ME2xPVYvOTVibl2= NVj2c5ZbW0GQR1XS
SK-MEL-30 M1LScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGK4V21KSzVyPUG5Ok4zKG6P M1PueXNCVkeHUh?=
DBTRG-05MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF7OD60O{BvVQ>? MXrTRW5ITVJ?
NCI-H1395 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjqSpFKSzVyPUG5PE45PSCwTR?= MV;TRW5ITVJ?
NCI-H2122 M{O4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGe4TXpKSzVyPUKwNE42QSCwTR?= NGKzVJVUSU6JRWK=
no-10 NV7QVVBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf2TWM2OD1{MEGuNFQhdk1? NHvwfVdUSU6JRWK=
SW48 NEXEOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj0R4RKSzVyPUKwNU4{OSCwTR?= NVe1bndkW0GQR1XS
NCI-H1650 NEjZSGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIL1dVFKSzVyPUKwOE4xOSCwTR?= MkDHV2FPT0WU
MZ1-PC NELVcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTJyNT61PEBvVQ>? NGTRNXBUSU6JRWK=
U-266 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDlTWM2OD1{MEWuO|khdk1? NWXLVYFwW0GQR1XS
CAS-1 M1HjZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O5VmlEPTB;MkC3MlQ1KG6P NFTk[2hUSU6JRWK=
AU565 M3HUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUj4e2poUUN3ME2yNVIvQDJibl2= MnrHV2FPT0WU
UACC-257 M{HucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELlPZZKSzVyPUKxN{46QSCwTR?= MlPFV2FPT0WU
CAL-27 MmLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H3VGlEPTB;MkG3MlA2KG6P NVjBbVZjW0GQR1XS
NCI-H23 MkTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nON2lEPTB;MkG5MlM{KG6P MnfBV2FPT0WU
TE-6 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG3W2lSUUN3ME2yNVkvPjhibl2= NUG2OlhlW0GQR1XS
TGBC24TKB M2qwfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJ{Mj6xO{BvVQ>? M3jTeHNCVkeHUh?=
TE-1 NXHLSoVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nJe2lEPTB;MkKyMlg5KG6P MV;TRW5ITVJ?
RCC10RGB NHrDZXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTJ{ND6xPUBvVQ>? NXL4WoF4W0GQR1XS
NCI-H596 NHPzW3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTJ{OD6yNkBvVQ>? MnmwV2FPT0WU
SW954 NUHGT|FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTJ|Mz64N{BvVQ>? MUDTRW5ITVJ?
NCI-H2087 Mn7BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ|ND61NUBvVQ>? NVrJNZBHW0GQR1XS
SK-PN-DW MnXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTJ|NT6xPUBvVQ>? Mo\0V2FPT0WU
KM12 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS2PXVnUUN3ME2yN|UvPyCwTR?= NUnHNJNjW0GQR1XS
BT-474 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PiW2lEPTB;MkO1Mlc{KG6P M1nZcHNCVkeHUh?=
IST-MES1 MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfEfmdKSzVyPUKzOk42PyCwTR?= MX3TRW5ITVJ?
HT-1197 NIfhfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ|OD6wPUBvVQ>? M{\mdXNCVkeHUh?=
CAL-54 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3r4SGlEPTB;MkO4MlQ6KG6P MVjTRW5ITVJ?
NB10 M13KWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjKVWhKSzVyPUK0NE4xPiCwTR?= M1zHOnNCVkeHUh?=
PANC-10-05 NIjyRY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPJTWM2OD1{NEWuOVYhdk1? NFzYVpRUSU6JRWK=
NCI-H522 NIC0T4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJ2OD6zNUBvVQ>? Mk\ZV2FPT0WU
A388 NGf6UG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULqS4J{UUN3ME2yOFkvQDJibl2= NXu1[mNtW0GQR1XS
GOTO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzadm1KSzVyPUK1NE4zQSCwTR?= NFG2O|FUSU6JRWK=
KLE M1[wUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7qTWM2OD1{NUGuPFchdk1? M3rtNXNCVkeHUh?=
KYSE-520 M4P4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJ3Mj64OkBvVQ>? NFXBdZdUSU6JRWK=
HCE-4 MoXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rWSGlEPTB;Mk[yMlUhdk1? NGjlc3lUSU6JRWK=
KURAMOCHI NF\XdlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIq4OJZKSzVyPUK2OU46KG6P M2q0enNCVkeHUh?=
HCC38 MlXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ4Nj60PEBvVQ>? MmHPV2FPT0WU
FADU MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO1bVRKSzVyPUK2Ok43OyCwTR?= NIXxemtUSU6JRWK=
CW-2 NUSzUlI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjNTWM2OD1{NkmuPVYhdk1? M4e2eHNCVkeHUh?=
L-428 M1\FXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37wcmlEPTB;Mke1MlE2KG6P NFWzdopUSU6JRWK=
HCC1569 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfrTWM2OD1{N{WuPFQhdk1? M1\UdXNCVkeHUh?=
NCI-H810 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTJ5OD6zNUBvVQ>? NVfkS3l7W0GQR1XS
LB771-HNC M1zk[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXkOGJKSzVyPUK4OU45PCCwTR?= NGDkSpVUSU6JRWK=
LCLC-103H NV63[WNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fpOmlEPTB;Mki1Mlk6KG6P NIPEUm9USU6JRWK=
EFO-21 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPtTWM2OD1{OEeuOlghdk1? NYXOUHhbW0GQR1XS
CAL-72 MorDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnafGtbUUN3ME2yPVMvOTlibl2= NIXvZpVUSU6JRWK=
SCC-9 NVr0R|FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTJ7Mz6yNkBvVQ>? MWHTRW5ITVJ?
COLO-829 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XKNGlEPTB;Mkm2MlUhdk1? MYrTRW5ITVJ?
U-87-MG NWfMNWpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzDS2p6UUN3ME2zNFAvPzNibl2= NILYfGFUSU6JRWK=
MZ7-mel Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO1TWM2OD1|MkOuO|Yhdk1? M2LSUnNCVkeHUh?=
NCI-H1770 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3q3SWlEPTB;M{K2Mlc1KG6P NGD1W3pUSU6JRWK=
ChaGo-K-1 M2\jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN{OD6xJI5O NGjRfGNUSU6JRWK=
SiHa NX;mdWVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuz[FhKSzVyPUOyPU4zPCCwTR?= MYXTRW5ITVJ?
NCI-SNU-5 NFTJcHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnOTWM2OD1|M{[uO|chdk1? MVrTRW5ITVJ?
DJM-1 NXnn[JM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3VUG5KSzVyPUO0NE4{OyCwTR?= NHLhOY1USU6JRWK=
OE19 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTN2MD61N{BvVQ>? NFX6W2hUSU6JRWK=
NCI-H1651 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTN2ND6xPEBvVQ>? NH\t[mRUSU6JRWK=
COLO-792 NU\tcmR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTN3ND60NkBvVQ>? M1G5WXNCVkeHUh?=
ACHN NXPIcmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXTeI5KSzVyPUO1Ok44OSCwTR?= NWjTbGdpW0GQR1XS
TH-3 M1:5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDGTWM2OD1|N{muPVUhdk1? NX:0eIpLW0GQR1XS
HT-1376 M3;J[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXkTWM2OD1|OESuPFghdk1? NXixTHlZW0GQR1XS
RH-18 NFHPOZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:1XVVKSzVyPUO5OE44PCCwTR?= M1TFNHNCVkeHUh?=
NB6 M{TKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTN7Nj62OkBvVQ>? NHjrRY1USU6JRWK=
COLO-320-HSR NGTTXJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTRyMz6zO{BvVQ>? MYTTRW5ITVJ?
UACC-893 MnfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnEblA1UUN3ME20NFYvPDdibl2= MXXTRW5ITVJ?
DSH1 NUPuTIhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XOR2lEPTB;NEC2MlkyKG6P MmHZV2FPT0WU
TE-10 M4Hhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKxVW55UUN3ME20NFcvODFibl2= NIfHd4lUSU6JRWK=
HCC70 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTDTWM2OD12MEmuNlEhdk1? NXf0S5pMW0GQR1XS
TGBC11TKB NF7pcVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT1OHpjUUN3ME20NVAvOzNibl2= NYX3d|VKW0GQR1XS
NCI-H727 NHPnNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTRzMj6xNUBvVQ>? NGLscmJUSU6JRWK=
ALL-PO NIOwcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRzNT62PUBvVQ>? NVy1U4M1W0GQR1XS
ABC-1 NXvr[45{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPNTWM2OD12MkCuOFUhdk1? MYLTRW5ITVJ?
NCI-H69 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X2NGlEPTB;NEK2Mlc3KG6P NXzydFlYW0GQR1XS
GP5d NGD2fFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLHR29UUUN3ME20N|QvPDFibl2= NXPmfGppW0GQR1XS
UMC-11 M2DUV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTR3OD6zOkBvVQ>? MoDiV2FPT0WU
RMG-I NVvFc2ZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTR4Nz61OkBvVQ>? NXP3fXliW0GQR1XS
YAPC NWTJdIVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFntW3hKSzVyPUS5NE43KG6P NEX4ZXRUSU6JRWK=
LS-1034 M1rwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHGwWlBKSzVyPUS5NU4xPiCwTR?= NFTUZmRUSU6JRWK=
RCM-1 MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTOUphxUUN3ME20PVYvPjhibl2= MlPwV2FPT0WU
HCC1954 NGTRU5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInBSlVKSzVyPUWxNk42KG6P NEHDS5NUSU6JRWK=
SK-MEL-24 NVTOSmZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTVzNj61NUBvVQ>? M3;xeXNCVkeHUh?=
NB12 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTV{OD60NkBvVQ>? MYTTRW5ITVJ?
SW756 M1fRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnIc3lKSzVyPUW1OE46PiCwTR?= MkPDV2FPT0WU
HCC1187 M{XC[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvUW4FKSzVyPUW3OU45OyCwTR?= NWXpbG5OW0GQR1XS
NCI-H2342 NXjKc4VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTV7MD6zPUBvVQ>? MWHTRW5ITVJ?
NCI-H2291 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPjbXZKSzVyPUW5PE4{OSCwTR?= NFTQWGFUSU6JRWK=
OVCAR-3 M4\zbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTJTWM2OD13OUiuPVYhdk1? MoHuV2FPT0WU
MHH-NB-11 NWHNRphHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTZ{OT6wNUBvVQ>? M3mzR3NCVkeHUh?=
SAS M2HnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDMOZN5UUN3ME22OVIvPjdibl2= NVy4S4lmW0GQR1XS
COLO-824 NXHnfZlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\lR4U5UUN3ME22PFkvOzdibl2= NYPxZW1JW0GQR1XS
HCC1395 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\0eGlEPTB;Nkm4MlUhdk1? NWHVcZAzW0GQR1XS
COLO-668 M1q0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXkXGxKSzVyPUewOk4yKG6P M17Se3NCVkeHUh?=
NCI-H226 M4jFT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfNcFVKSzVyPUewO{45KG6P MVTTRW5ITVJ?
NB17 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjNSmREUUN3ME23NlEvPzVibl2= MoTjV2FPT0WU
SW1463 NGXvT4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTd|OT6xPUBvVQ>? MnfSV2FPT0WU
TGW MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PDU2lEPTB;N{[wMlE2KG6P NUnzNJhmW0GQR1XS
NCI-H526 M{ewT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTh{Mz61N{BvVQ>? NIHYe5JUSU6JRWK=
COR-L88 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3ITI1qUUN3ME24OFgvOTJibl2= M1jXWHNCVkeHUh?=
NCI-H441 NHTjUHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTh7NT6yNkBvVQ>? MmDqV2FPT0WU
NCI-H630 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILYTItKSzVyPUmxNk46PiCwTR?= M{fWRnNCVkeHUh?=
Mo-T NV32O3BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXhfnVvUUN3ME25OFcvQDhibl2= MUnTRW5ITVJ?
JAR MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3OcXZOUUN3ME25OVYvOjRibl2= M4XMXXNCVkeHUh?=
NCI-H1838 NVvKfnBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPYbIVkUUN3ME2xMlAzOzh6IN88US=> M3\4[HNCVkeHUh?=
DoTc2-4510 NHzwV5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTFwMEezO|Yh|ryP NU\HfmxjW0GQR1XS
MKN28 NHf5fYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vGZmlEPTB;MT6wPVAzPCEQvF2= MnnNV2FPT0WU
HuP-T3 NITVOIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvyTWM2OD1zLkGxPVA2KM7:TR?= M2\lbXNCVkeHUh?=
TE-9 NXG0TlhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;OSWlEPTB;MT6xNlk4OyEQvF2= M33zbnNCVkeHUh?=
NY MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzLcZBbUUN3ME2xMlE3Pzl{IN88US=> NYDtb|V1W0GQR1XS
HT55 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwM{GzOFQh|ryP MnL3V2FPT0WU
SW837 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWyN5V5UUN3ME2xMlMzQTd6IN88US=> NW\ZeHc3W0GQR1XS
NCI-H2029 NGP1ZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fEd2lEPTB;MT60NVc6OSEQvF2= NW\oZ2drW0GQR1XS
IST-SL1 Mny1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTFwNESyOEDPxE1? Mk\KV2FPT0WU
COLO-741 NUW3[VZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1zLkS5O|cyKM7:TR?= MoPjV2FPT0WU
LU-65 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L4N2lEPTB;MT62NlI1QSEQvF2= NFL4flBUSU6JRWK=
NCI-H1304 NUTZVGtpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrKTWM2OD1zLk[1OFk5KM7:TR?= MXvTRW5ITVJ?
KARPAS-299 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTETWM2OD1zLke5OFc6KM7:TR?= M2\ab3NCVkeHUh?=
NCI-H358 M3j2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwOUW1NFMh|ryP MYTTRW5ITVJ?
OAW-28 NHzUfI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwME[5NVkh|ryP MW\TRW5ITVJ?
C8166 M{fwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv1TWM2OD1{Lk[zN|kzKM7:TR?= MkLqV2FPT0WU
COLO-678 NHXkcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n6bmlEPTB;Mj64N|c3QCEQvF2= NWrFd4xOW0GQR1XS
SK-N-DZ NEfReHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrvSopKSzVyPUKuPFY{QDFizszN Mo\4V2FPT0WU
NCI-H82 MkTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NImyTpNKSzVyPUKuPVA{PjlizszN Mn\BV2FPT0WU
JVM-2 NWTG[|FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r6dGlEPTB;Mz6wN|E5QCEQvF2= M1\4ZnNCVkeHUh?=
SW1116 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorrTWM2OD1|LkC1OFEyKM7:TR?= NF;YU2hUSU6JRWK=
MDA-MB-453 M4Lj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnJTWM2OD1|LkGwOFM6KM7:TR?= M4HReHNCVkeHUh?=
Calu-6 NHzBS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvleZhwUUN3ME2zMlE6QTdizszN Ml\GV2FPT0WU
SHP-77 NEHLXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nl[2lEPTB;Mz61Nlgh|ryP MkX2V2FPT0WU
Capan-2 Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEW3eGlKSzVyPUSuN|I2QDFizszN M2fVd3NCVkeHUh?=
SW948 NU\CeJpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PNVWlEPTB;ND63OFc4QSEQvF2= NY\GNVl[W0GQR1XS
HDLM-2 M2GwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTVwMEe3NlUh|ryP NGHoNZVUSU6JRWK=
LAN-6 MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFT6NWpKSzVyPU[uNlE1QTVizszN NIXZZoFUSU6JRWK=
LU-135 MkezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTZwNEOwO|ch|ryP M4LmdnNCVkeHUh?=
T84 NGLkenhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zRT2lEPTB;Nj65PFY1KM7:TR?= NV3E[Iw4W0GQR1XS
CAPAN-1 MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrNTWM2OD15Lk[yNlM{KM7:TR?= NVrPeYY1W0GQR1XS
SW1417 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7wOJJKSzVyPUeuPVE4OzFizszN NH61c5hUSU6JRWK=
BALL-1 NXLJWoE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r4e2lEPTB;OD61NFQxQSEQvF2= M37xSHNCVkeHUh?=
HT-29 NF7zcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\HUIxKSzVyPUmuNFc2QTlizszN NVrNRW9pW0GQR1XS
C3A M3y4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrYbppKSzVyPUmuPFg{QTRizszN Mo\BV2FPT0WU
NCI-H1993 NGPX[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LzZ2lEPTB;MUCuOVA5OSEQvF2= M3:zPXNCVkeHUh?=
SK-MEL-1 M4XRbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnNVZp{UUN3ME2xNU43Ojh7IN88US=> NX\wNZRnW0GQR1XS
DU-145 M33SUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnKWYFYUUN3ME2xOE42ODV{IN88US=> NH;1[FNUSU6JRWK=
KP-N-YN NEHGRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXrXIhlUUN3ME2xOE42OTB|IN88US=> NFzKeZBUSU6JRWK=
CCRF-CEM MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLkdXRKSzVyPUG0Mlc5ODlizszN MXHTRW5ITVJ?
ZR-75-30 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF4LkOzNFMh|ryP NEHwdpNUSU6JRWK=
A673 M1XrZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTyTWM2OD1{MD61OVA4KM7:TR?= NWXXU2ZTW0GQR1XS
K-562 NXPaUFlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoW4TWM2OD1{OD60NVg{KM7:TR?= NEeyRXRUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+polyethylene glycol 300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT03373903 Active not recruiting Respiratory Tract Infections Restorbio Inc. November 15 2017 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products5

Tags: buy Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) supplier | purchase Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) cost | Dactolisib (BEZ235, NVP-BEZ235) manufacturer | order Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID