Dactolisib (BEZ235)

For research use only. Not for use in humans.

Catalog No.S1009 Synonyms: NVP-BEZ235

258 publications

Dactolisib (BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

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Selleck's Dactolisib (BEZ235) has been cited by 258 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MW\BcpRqdWmlcn;ibYFtKEG|c3H5 NGrUSnMyQCCq NUfOemZmTE2VTx?= NFnlbHZCdnSrdIL5dIFvd3OxbXHsJIFkfGm4aYT5JJdqfGhiRVO1NEBw\iByLkCwNlUh|ryP NH75O3AzPDhyNUm0Oi=>
MCF7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXKwMlAyNTFyMDFOwG0> MmrMOFghcA>? MYDEUXNQ M{iyXWlEPTB;MD63N{DPxE1? MVKyN|g4OTlyNB?=
HCT116 NXrvR4tIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HVTFAvODFvMUCwJO69VQ>? NUHHTGVPPDhiaB?= MlrZSG1UVw>? NWPVU5dvUUN3ME2xMlE3KM7:TR?= NFHIUYYzOzh5MUmwOC=>
U87MG M{j1R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTFT3poOC5yMT2xNFAh|ryP NFLFepk1QCCq NFfXZmVFVVOR NXHFRnczUUN3ME2xMlMzKM7:TR?= NXnydpdCOjN6N{G5NFQ>
HBC4 NUTjNYJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rFXlAvODFvMUCwJO69VQ>? MlXlOFghcA>? NIDQd2pNd2diR1m1NF0uQC54MTDN NEjYW2UzOjN|NkK0Oi=>
BSY1 M4nQWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrvZoZYOC5yMT2xNFAh|ryP NGixS|E1QCCq Ml72UI9oKEeLNUC9MVgvPDhiTR?= NGHTN4ozOjN|NkK0Oi=>
HBC5 M3zObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFmwZoQxNjBzLUGwNEDPxE1? MmTqOFghcA>? NIPYTFRNd2diR1m1NF0uPy56NzDN M{DyflIzOzN4MkS2
MCF7 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrsN413OC5yMT2xNFAh|ryP NXTZc3pvPDhiaB?= NFvPbmlNd2diR1m1NF0uQC5zNjDN Mmi4NlI{OzZ{NE[=
MDA-MB-231 NW\vNXdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVWwMlAyNTFyMDFOwG0> NVfJOIk5PDhiaB?= NIPTNVVNd2diR1m1NF0uQC5yOTDN M{PoVFIzOzN4MkS2
U251 MkLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfq[pAxNjBzLUGwNEDPxE1? M2jMVlQ5KGh? M2\mZ2xw\yCJSUWwQU04NjZ4IF2= NFTmS2YzOjN|NkK0Oi=>
SF268 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfFNE4xOS1zMECg{txO MXK0PEBp Mn\oUI9oKEeLNUC9MVcvQTJiTR?= NUHuNY1tOjJ|M{[yOFY>
SF295 M4P1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH0d2gxNjBzLUGwNEDPxE1? M3;xWVQ5KGh? M{n5cmxw\yCJSUWwQU05NjNzIF2= M{LKXVIzOzN4MkS2
SF539 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DKZ|AvODFvMUCwJO69VQ>? MnfLOFghcA>? M{TCc2xw\yCJSUWwQU05NjV7IF2= NXr5VXZjOjJ|M{[yOFY>
SNB75 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3uNE4xOS1zMECg{txO NEL1PVk1QCCq NYCz[2l2VG:pIFfJOVA:NThwNUigUS=> M2r3R|IzOzN4MkS2
SNB78 NHq5fWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13pfVAvODFvMUCwJO69VQ>? NUTGfWxTPDhiaB?= MXzMc4chT0l3ME2tPE43PSCP NGXzXlAzOjN|NkK0Oi=>
HCC2998 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXewMlAyNTFyMDFOwG0> NGLOWHg1QCCq NFPNUodNd2diR1m1NF0uQC5yNTDN MV:yNlM{PjJ2Nh?=
KM12 M{DEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXywMlAyNTFyMDFOwG0> NFiyPIk1QCCq NXPoPZFQVG:pIFfJOVA:NTdwNUSgUS=> MYmyNlM{PjJ2Nh?=
HT-29 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXENE4xOS1zMECg{txO Mkf3OFghcA>? MUHMc4chT0l3ME2tO{44PSCP NXj1foZyOjJ|M{[yOFY>
HCT15 M2\wWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M130clAvODFvMUCwJO69VQ>? MX20PEBp MWDMc4chT0l3ME2tPE4xOyCP MVeyNlM{PjJ2Nh?=
HCT116 NUXxSIJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLCNE4xOS1zMECg{txO Mo\ROFghcA>? MVLMc4chT0l3ME2tO{43OSCP M2XueFIzOzN4MkS2
NCI-H23 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\y[FNoOC5yMT2xNFAh|ryP NWP3[nVmPDhiaB?= NW\GfFFbVG:pIFfJOVA:NTdwNkSgUS=> M{PCd|IzOzN4MkS2
NCI-H226 NFfFR5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjONE4xOS1zMECg{txO M2jBTlQ5KGh? NWTacHdRVG:pIFfJOVA:NThwNESgUS=> MkfrNlI{OzZ{NE[=
NCI-H522 M4nxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrDNE4xOS1zMECg{txO M2TQW|Q5KGh? NFzCTVFNd2diR1m1NF0uQC52NTDN NFPOSIszOjN|NkK0Oi=>
NCI-H438 NHrBOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWwMlAyNTFyMDFOwG0> NU\XU5k4PDhiaB?= NULYelc1VG:pIFfJOVA:NThwMUGgUS=> MVqyNlM{PjJ2Nh?=
A549 Mn3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HId|AvODFvMUCwJO69VQ>? NULUXGtxPDhiaB?= NF62S3RNd2diR1m1NF0uQC5yNzDN NYX0fZRIOjJ|M{[yOFY>
DMS273 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWOwMlAyNTFyMDFOwG0> NEfQcZY1QCCq MkPHUI9oKEeLNUC9MVcvQDBiTR?= NYDPOXd7OjJ|M{[yOFY>
DMS114 NWjZPHVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLwbGpLOC5yMT2xNFAh|ryP NVO3d|cyPDhiaB?= NWrKSYJCVG:pIFfJOVA:NThwM{mgUS=> NXXUSHhkOjJ|M{[yOFY>
LOXIMVI MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHVTJExNjBzLUGwNEDPxE1? NGPKdoE1QCCq NE\rUppNd2diR1m1NF0uQC54NjDN NEP1fIIzOjN|NkK0Oi=>
OVCAR3 NYHLXJpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f5dFAvODFvMUCwJO69VQ>? M{\KWlQ5KGh? MUjMc4chT0l3ME2tPE4yPyCP MYeyNlM{PjJ2Nh?=
OVCAR4 M2D0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Hh[lAvODFvMUCwJO69VQ>? NV7LNY0yPDhiaB?= NELBe4xNd2diR1m1NF0uQC53ODDN M4W0WVIzOzN4MkS2
OVCAR5 M4PZcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTQNE4xOS1zMECg{txO NUf6fVkzPDhiaB?= MmXTUI9oKEeLNUC9MVcvPTdiTR?= Mn;pNlI{OzZ{NE[=
OVCAR8 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXaNE4xOS1zMECg{txO NWL6TmJxPDhiaB?= NGjHUJBNd2diR1m1NF0uPy56NDDN MXmyNlM{PjJ2Nh?=
SKOV3 NV6zTHlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M132T|AvODFvMUCwJO69VQ>? MUW0PEBp NXqwRY5[VG:pIFfJOVA:NThwNEGgUS=> NY\pV4ExOjJ|M{[yOFY>
RXF631L NF6xR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPJZ3YxNjBzLUGwNEDPxE1? MorjOFghcA>? NUjDWVNZVG:pIFfJOVA:NThwMkGgUS=> M3n3O|IzOzN4MkS2
ACHN NH\tRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXywMlAyNTFyMDFOwG0> NV71OJlbPDhiaB?= MVTMc4chT0l3ME2tO{46PSCP NU\EenlkOjJ|M{[yOFY>
St-4 NVH1TW9VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuzTJoxNjBzLUGwNEDPxE1? MYm0PEBp NUPzOY5WVG:pIFfJOVA:NTdwNEegUS=> MmruNlI{OzZ{NE[=
MKN1 NHjlZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV60dJplOC5yMT2xNFAh|ryP M3XtRlQ5KGh? NFvwdndNd2diR1m1NF0uQC52MTDN NVTE[FRqOjJ|M{[yOFY>
MKN7 MnezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[0b|AvODFvMUCwJO69VQ>? NY[xZmZ4PDhiaB?= M2fJWGxw\yCJSUWwQU04NjZ6IF2= MWKyNlM{PjJ2Nh?=
MKN28 M2j1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MViwMlAyNTFyMDFOwG0> MUG0PEBp MXPMc4chT0l3ME2tO{4xPyCP M4fPUFIzOzN4MkS2
MKN45 NH\YSlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDuXpFyOC5yMT2xNFAh|ryP NHKxNXE1QCCq MWjMc4chT0l3ME2tPE4{PCCP M2TkflIzOzN4MkS2
MKN74 NVzPVoJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVKwMlAyNTFyMDFOwG0> M4DLelQ5KGh? NIPpNoxNd2diR1m1NF0uPy52MjDN NYHBXJozOjJ|M{[yOFY>
DU145 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnZZoxyOC5yMT2xNFAh|ryP M{npe|Q5KGh? NUHJeoVjVG:pIFfJOVA:NThwMU[gUS=> NW\yUWNbOjJ|M{[yOFY>
PC3 M4q1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PGN|AvODFvMUCwJO69VQ>? M{GwfFQ5KGh? NFr6[ItNd2diR1m1NF0uQC54NjDN NXqwNlZGOjJ|M{[yOFY>
Trypanosoma brucei brucei Ml;lSpVv[3Srb36gRZN{[Xl? NHWydGgzODBibl2= NUT5ZnFbOTJiaB?= MlS3SG1UVw>? NWCydJpDTGWlcnXhd4UhcW5icHjvd5Bpd3SrZInsJIlvd3OrdH;sJJBpd3OyaHH0[UBt\X[nbB?= M1:5cVI1QDB3OUS2
Trypanosoma brucei brucei NECxO41HfW6ldHnvckBCe3OjeR?= NWXRfHZLOThiaB?= M3HoRWROW09? MUPJcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? NH25U5czPDhyNUm0Oi=>
Trypanosoma brucei brucei MkDKSpVv[3Srb36gRZN{[Xl? NIi0NWUzODBibl2= NV:5SGdSOTJiaB?= MlHVSG1UVw>? MlzkSYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> MnruNlQ5ODV7NE[=
Trypanosoma brucei brucei MlzlSpVv[3Srb36gRZN{[Xl? MlG5NlAxKG6P MnjYNVIhcA>? NFT3PYpFVVOR M2[5eGVn\mWldDDvckBxcG:|cHjheIllgWylaH;sbY5mKGyndnXs NEnPVGozPDhyNUm0Oi=>
UM-UC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTNzNTDwUS=> MXrTRW5ITVJ?
SBC-1 NWLx[3NtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTd2MjDwUS=> NH3IPYxUSU6JRWK=
MKN1 NIL4dYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vhVmlEPTB;Mj64JI5O MlflV2FPT0WU
NCI-H720 NUfkN|cyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC1TItKSzVyPUOuOVchdk1? MVzTRW5ITVJ?
BFTC-909 M4L3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;5fpBVUUN3ME2zMlcyKG6P M4\mVXNCVkeHUh?=
BPH-1 M4jxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGWz[HJKSzVyPUSuO|Yhdk1? MlvQV2FPT0WU
PC-3 Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH21S4dKSzVyPUWuNFkhdk1? MnfKV2FPT0WU
AN3-CA M{PIcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC4TWM2OD13LkW2JI5O NXvteoN7W0GQR1XS
HN MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTVwOU[gcm0> MnTnV2FPT0WU
HCC2218 M2fWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XVRWlEPTB;Nj62NUBvVQ>? NHLQNXNUSU6JRWK=
KP-4 M1q0Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;NToJKSzVyPUegcm0> NGrydppUSU6JRWK=
LU-139 NX\KTVl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTdwN{egcm0> NWHUbG1qW0GQR1XS
ETK-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jN[WlEPTB;Nz64PEBvVQ>? NHnBOmpUSU6JRWK=
Ramos-2G6-4C10 NY\aPVBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DIUWlEPTB;OD60PUBvVQ>? MWfTRW5ITVJ?
MHH-PREB-1 NUDFXHdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPT[npKSzVyPUmuNVIhdk1? M2[4eXNCVkeHUh?=
DU-4475 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DLWGlEPTB;OT60OEBvVQ>? Mny2V2FPT0WU
NCI-H1666 Mnz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTlwN{Ggcm0> M1O1U3NCVkeHUh?=
CAMA-1 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknUTWM2OD17Lkigcm0> MUPTRW5ITVJ?
TYK-nu NF7QTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;STWM2OD17Lkm0JI5O M3qyZ3NCVkeHUh?=
MFE-280 NXjiN2FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XtN2lEPTB;OT65PUBvVQ>? MYfTRW5ITVJ?
A549 M4nPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13UVmlEPTB;MUCuNVQhdk1? NHLHW4NUSU6JRWK=
769-P MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{GyW2lEPTB;MUCuOFQhdk1? MXHTRW5ITVJ?
L-363 NVjYOVJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvnTWM2OD1zMD62PUBvVQ>? MorkV2FPT0WU
ES8 MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLJTWM2OD1zMD65JI5O MofoV2FPT0WU
PA-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXS[GdKSzVyPUGxMlgzKG6P NXLOco5NW0GQR1XS
Mewo M1:5b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljmTWM2OD1zMT65PUBvVQ>? MYXTRW5ITVJ?
HSC-3 M{CyO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfvTWM2OD1zMj6yNUBvVQ>? M3LtT3NCVkeHUh?=
H4 Mn32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HNbGlEPTB;MUKuOlchdk1? M{Dze3NCVkeHUh?=
BB65-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\uPFFHUUN3ME2xNk44OiCwTR?= M33nbHNCVkeHUh?=
NCI-H1793 MljmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPNOGRKSzVyPUGyMlgzKG6P NFnqXFNUSU6JRWK=
KARPAS-45 NVLnNHdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[wTWM2OD1zMz61NUBvVQ>? M3vE[HNCVkeHUh?=
GCT MlvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF|Lk[4JI5O MXrTRW5ITVJ?
EoL-1 Ml60S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHGUFNSUUN3ME2xN{46OyCwTR?= NVW5S4Z[W0GQR1XS
LB2241-RCC MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4P1TmlEPTB;MUSuNFEhdk1? NV\acVhHW0GQR1XS
ES5 NVLEZ5htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTF2Lke0JI5O M1XOWHNCVkeHUh?=
LOXIMVI NWHwS3k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO1TWM2OD1zND65PUBvVQ>? M4XESXNCVkeHUh?=
COR-L105 MnfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrJZpRKSzVyPUG1MlA1KG6P M2e0UnNCVkeHUh?=
P12-ICHIKAWA NFnKboVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF3LkGgcm0> MlHkV2FPT0WU
CHL-1 NEDTV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH70dFVKSzVyPUG1MlQ2KG6P MUDTRW5ITVJ?
VMRC-RCZ NYWxRZc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O4SWlEPTB;MUWuOlMhdk1? Mnv3V2FPT0WU
HH NG\aNYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L6RmlEPTB;MUWuO{BvVQ>? Mo\rV2FPT0WU
NUGC-3 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjofVhjUUN3ME2xOk4{PCCwTR?= NWryXG5vW0GQR1XS
EGI-1 MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:3TWM2OD1zNj60N{BvVQ>? MY\TRW5ITVJ?
OS-RC-2 Mn;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF4LkS3JI5O MYDTRW5ITVJ?
MOLT-16 MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofLTWM2OD1zNz6xOUBvVQ>? NH3I[mNUSU6JRWK=
NCI-H209 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTF5LkK5JI5O MknnV2FPT0WU
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BT-474 NXS1W2lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m0UmlEPTB;MkO1Mlc{KG6P M1LnfHNCVkeHUh?=
IST-MES1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XNXGlEPTB;MkO2MlU4KG6P Mor2V2FPT0WU
HT-1197 M3\XZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTWTWM2OD1{M{iuNFkhdk1? MWLTRW5ITVJ?
CAL-54 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJ|OD60PUBvVQ>? NHzhPZZUSU6JRWK=
NB10 M1\4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfWVGhRUUN3ME2yOFAvODZibl2= Mn\CV2FPT0WU
PANC-10-05 NUTvS4dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfUfnVKSzVyPUK0OU42PiCwTR?= NYTBUFRFW0GQR1XS
NCI-H522 M1LQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XvVWlEPTB;MkS4MlMyKG6P M1:zd3NCVkeHUh?=
A388 M2\NUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPGNlYyUUN3ME2yOFkvQDJibl2= MlTrV2FPT0WU
GOTO M3\VUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJ3MD6yPUBvVQ>? MUPTRW5ITVJ?
KLE MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrVeXZ2UUN3ME2yOVEvQDdibl2= MoWxV2FPT0WU
KYSE-520 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\mUWlEPTB;MkWyMlg3KG6P NGLm[5FUSU6JRWK=
HCE-4 M4\uZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i5cGlEPTB;Mk[yMlUhdk1? MULTRW5ITVJ?
KURAMOCHI MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTW[YpKSzVyPUK2OU46KG6P Moi4V2FPT0WU
HCC38 NVHrWVFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTFOotKSzVyPUK2Ok41QCCwTR?= NVfkblBWW0GQR1XS
FADU NHvIcHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\OVFdKSzVyPUK2Ok43OyCwTR?= NEDhSWZUSU6JRWK=
CW-2 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7MNGVKSzVyPUK2PU46PiCwTR?= M3vTdnNCVkeHUh?=
L-428 M4DqNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nOZWlEPTB;Mke1MlE2KG6P NUXJN2RqW0GQR1XS
HCC1569 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjmTWM2OD1{N{WuPFQhdk1? Mny3V2FPT0WU
NCI-H810 NF\ISXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXiTWM2OD1{N{iuN|Ehdk1? MkTzV2FPT0WU
LB771-HNC Mn22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfKVXJqUUN3ME2yPFUvQDRibl2= NH:2OoNUSU6JRWK=
LCLC-103H NWXCVIpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLITWM2OD1{OEWuPVkhdk1? MYXTRW5ITVJ?
EFO-21 M4K0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;qO2pKSzVyPUK4O{43QCCwTR?= NFT3bFBUSU6JRWK=
CAL-72 NXjsO45nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LMSGlEPTB;MkmzMlE6KG6P MUTTRW5ITVJ?
SCC-9 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjXR49KSzVyPUK5N{4zOiCwTR?= M4DqSXNCVkeHUh?=
COLO-829 M1jG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPhR5RXUUN3ME2yPVYvPSCwTR?= NYDudGt5W0GQR1XS
U-87-MG M4Hjb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvOTWM2OD1|MECuO|Mhdk1? M4fZSXNCVkeHUh?=
MZ7-mel M2X6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n3NGlEPTB;M{KzMlc3KG6P MX\TRW5ITVJ?
NCI-H1770 NVP3epQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1r6T2lEPTB;M{K2Mlc1KG6P NV\TcI5tW0GQR1XS
ChaGo-K-1 NHfqbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrzTWM2OD1|MkiuNUBvVQ>? M{jRe3NCVkeHUh?=
SiHa Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzvPI1KSzVyPUOyPU4zPCCwTR?= MXPTRW5ITVJ?
NCI-SNU-5 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3VTWM2OD1|M{[uO|chdk1? MVjTRW5ITVJ?
DJM-1 M4PNNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN2MD6zN{BvVQ>? NVrHcpB6W0GQR1XS
OE19 NH\xe5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfOZ4V5UUN3ME2zOFAvPTNibl2= MVLTRW5ITVJ?
NCI-H1651 NUmwb2ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPndnVKSzVyPUO0OE4yQCCwTR?= MWTTRW5ITVJ?
COLO-792 NWPQNGRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3zTWM2OD1|NUSuOFIhdk1? M{W5WXNCVkeHUh?=
ACHN NXO4[nhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDxTWM2OD1|NU[uO|Ehdk1? NUX6WGsxW0GQR1XS
TH-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP0V5h4UUN3ME2zO|kvQTVibl2= MkjmV2FPT0WU
HT-1376 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfiTWM2OD1|OESuPFghdk1? M3;4fXNCVkeHUh?=
RH-18 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN7ND63OEBvVQ>? NELETZhUSU6JRWK=
NB6 Mn;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfuTXg1UUN3ME2zPVYvPjZibl2= NX\wUFB4W0GQR1XS
COLO-320-HSR NF\u[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFOzTXRKSzVyPUSwN{4{PyCwTR?= M{OzZnNCVkeHUh?=
UACC-893 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTRyNj60O{BvVQ>? MlrwV2FPT0WU
DSH1 NEf2eGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPk[lRQUUN3ME20NFYvQTFibl2= M2DHS3NCVkeHUh?=
TE-10 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3YTXlKSzVyPUSwO{4xOSCwTR?= M{jkWXNCVkeHUh?=
HCC70 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnCUVdKSzVyPUSwPU4zOSCwTR?= NVPLXXBrW0GQR1XS
TGBC11TKB MlzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInFT2xKSzVyPUSxNE4{OyCwTR?= M17CVXNCVkeHUh?=
NCI-H727 NVu5cndvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\GTWM2OD12MUKuNVEhdk1? NYTUeY9[W0GQR1XS
ALL-PO MoHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknqTWM2OD12MUWuOlkhdk1? MXzTRW5ITVJ?
ABC-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlX3TWM2OD12MkCuOFUhdk1? NX7KVodwW0GQR1XS
NCI-H69 NUf5VJo{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLy[XRKSzVyPUSyOk44PiCwTR?= NYr4W3hJW0GQR1XS
GP5d MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPoOVJyUUN3ME20N|QvPDFibl2= NFH5VoNUSU6JRWK=
UMC-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTR3OD6zOkBvVQ>? NFrnT2VUSU6JRWK=
RMG-I M3n5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWexO4l[UUN3ME20OlcvPTZibl2= M3;kfHNCVkeHUh?=
YAPC MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfvTpFSUUN3ME20PVAvPiCwTR?= Ml:1V2FPT0WU
LS-1034 NIfDdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr4OYpyUUN3ME20PVEvODZibl2= NWnnTIxKW0GQR1XS
RCM-1 M3LBV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTR7Nj62PEBvVQ>? MXrTRW5ITVJ?
HCC1954 M4fp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jsdmlEPTB;NUGyMlUhdk1? MV;TRW5ITVJ?
SK-MEL-24 MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\6SYIzUUN3ME21NVYvPTFibl2= Mlf2V2FPT0WU
NB12 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr4TWM2OD13MkiuOFIhdk1? NWjZR2lSW0GQR1XS
SW756 NWi5UlQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTZd5lKSzVyPUW1OE46PiCwTR?= M{THWHNCVkeHUh?=
HCC1187 Mlv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIqxPXBKSzVyPUW3OU45OyCwTR?= NYPCcnV4W0GQR1XS
NCI-H2342 M13CNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC3TWM2OD13OUCuN|khdk1? MnzwV2FPT0WU
NCI-H2291 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXRN3JKSzVyPUW5PE4{OSCwTR?= M2\YeXNCVkeHUh?=
OVCAR-3 NF[4R4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTVTWM2OD13OUiuPVYhdk1? NYe5O3lPW0GQR1XS
MHH-NB-11 NYHGb5JHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLETWM2OD14MkmuNFEhdk1? MnrjV2FPT0WU
SAS M33D[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PXOGlEPTB;NkWyMlY4KG6P NFnDVVhUSU6JRWK=
COLO-824 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHkflJJUUN3ME22PFkvOzdibl2= NWjleGVWW0GQR1XS
HCC1395 M2jsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXIW4c2UUN3ME22PVgvPSCwTR?= Mn30V2FPT0WU
COLO-668 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LXWWlEPTB;N{C2MlEhdk1? MXTTRW5ITVJ?
NCI-H226 MlnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHXfHI1UUN3ME23NFcvQCCwTR?= MXfTRW5ITVJ?
NB17 NEDpUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTd{MT63OUBvVQ>? MnriV2FPT0WU
SW1463 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr0VZZKSzVyPUezPU4yQSCwTR?= MnG0V2FPT0WU
TGW MlK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTd4MD6xOUBvVQ>? MkHCV2FPT0WU
NCI-H526 NY\zRmZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2S0PGlEPTB;OEKzMlU{KG6P MmLsV2FPT0WU
COR-L88 MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET2O5dKSzVyPUi0PE4yOiCwTR?= M37xO3NCVkeHUh?=
NCI-H441 NHLIXI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX3TWM2OD16OUWuNlIhdk1? NEHNXJlUSU6JRWK=
NCI-H630 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHaTWM2OD17MUKuPVYhdk1? MkGyV2FPT0WU
Mo-T NG\KWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLKTWM2OD17NEeuPFghdk1? M{TMNnNCVkeHUh?=
JAR MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn0SnlwUUN3ME25OVYvOjRibl2= NHP6U3VUSU6JRWK=
NCI-H1838 Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fmOGlEPTB;MT6wNlM5QCEQvF2= NUXaV3hSW0GQR1XS
DoTc2-4510 M1q3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfWR|JKSzVyPUGuNFc{PzZizszN MoPnV2FPT0WU
MKN28 NVXO[3hZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\v[YNKSzVyPUGuNFkxOjRizszN NXvLbm85W0GQR1XS
HuP-T3 NVzpeVFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7nTWM2OD1zLkGxPVA2KM7:TR?= NIjYcIhUSU6JRWK=
TE-9 NF\meG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTFwMUK5O|Mh|ryP MWPTRW5ITVJ?
NY M1v0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPnS5VKSzVyPUGuNVY4QTJizszN M133NXNCVkeHUh?=
HT55 M4XYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTFwM{GzOFQh|ryP M3r2PHNCVkeHUh?=
SW837 NXvTRWpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqzOVdpUUN3ME2xMlMzQTd6IN88US=> NHLuOJdUSU6JRWK=
NCI-H2029 MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFwNEG3PVEh|ryP NVjVWlBGW0GQR1XS
IST-SL1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTFwNESyOEDPxE1? M3LvdHNCVkeHUh?=
COLO-741 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGwUXZKSzVyPUGuOFk4PzFizszN M{m2PXNCVkeHUh?=
LU-65 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvp[2NKSzVyPUGuOlIzPDlizszN NFLiXnpUSU6JRWK=
NCI-H1304 NHvPVpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPQTWM2OD1zLk[1OFk5KM7:TR?= NX7F[IZGW0GQR1XS
KARPAS-299 NIHST|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP5TWM2OD1zLke5OFc6KM7:TR?= NFPnWGNUSU6JRWK=
NCI-H358 NIjzPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmz[FJNUUN3ME2xMlk2PTB|IN88US=> MmjRV2FPT0WU
OAW-28 NYP5S5NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXq4UIcyUUN3ME2yMlA3QTF7IN88US=> NWDyUIFbW0GQR1XS
C8166 NEiwdGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfnfZpTUUN3ME2yMlY{Ozl{IN88US=> MX7TRW5ITVJ?
COLO-678 NUfGTXlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xxc2lEPTB;Mj64N|c3QCEQvF2= MknOV2FPT0WU
SK-N-DZ MofqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXlVnVKSzVyPUKuPFY{QDFizszN MWPTRW5ITVJ?
NCI-H82 NEnN[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NImzbXBKSzVyPUKuPVA{PjlizszN MYfTRW5ITVJ?
JVM-2 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrvTWM2OD1|LkCzNVg5KM7:TR?= M{\qTXNCVkeHUh?=
SW1116 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTNwMEW0NVEh|ryP MmfyV2FPT0WU
MDA-MB-453 NF76TZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULQU|NQUUN3ME2zMlExPDN7IN88US=> M{iyRXNCVkeHUh?=
Calu-6 M4\4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT1TWM2OD1|LkG5PVch|ryP MnjZV2FPT0WU
SHP-77 NYrSflFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\2TWM2OD1|LkWyPEDPxE1? M4e5TXNCVkeHUh?=
Capan-2 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[wNWlEPTB;ND6zNlU5OSEQvF2= NGXHXYFUSU6JRWK=
SW948 NFu1NVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRwN{S3O|kh|ryP M2W5WXNCVkeHUh?=
HDLM-2 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PXSWlEPTB;NT6wO|czPSEQvF2= NUjadZVOW0GQR1XS
LAN-6 MneyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\RUGlEPTB;Nj6yNVQ6PSEQvF2= MVzTRW5ITVJ?
LU-135 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HOSGlEPTB;Nj60N|A4PyEQvF2= MlrIV2FPT0WU
T84 NVi3NnlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIL4Z|lKSzVyPU[uPVg3PCEQvF2= Ml;aV2FPT0WU
CAPAN-1 M335[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXLTYRKSzVyPUeuOlIzOzNizszN NUThW4p4W0GQR1XS
SW1417 NIDsdVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjZW21TUUN3ME23MlkyPzNzIN88US=> M1rzUHNCVkeHUh?=
BALL-1 NVjhc49iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PBd2lEPTB;OD61NFQxQSEQvF2= MWPTRW5ITVJ?
HT-29 M4DFPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknvTWM2OD17LkC3OVk6KM7:TR?= MULTRW5ITVJ?
C3A MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnGTWM2OD17Lki4N|k1KM7:TR?= NFjGS5ZUSU6JRWK=
NCI-H1993 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2f1[WlEPTB;MUCuOVA5OSEQvF2= MWDTRW5ITVJ?
SK-MEL-1 NImyWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFzLk[yPFkh|ryP M1nXTHNCVkeHUh?=
DU-145 M2ThVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S0VGlEPTB;MUSuOVA2OiEQvF2= NF[1[2dUSU6JRWK=
KP-N-YN Mlj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrGTWM2OD1zND61NVA{KM7:TR?= NH\qfWFUSU6JRWK=
CCRF-CEM NIDsZW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;3PJVKSzVyPUG0Mlc5ODlizszN MlOyV2FPT0WU
ZR-75-30 MkfmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF4LkOzNFMh|ryP NGP6dppUSU6JRWK=
A673 M{TlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TL[2lEPTB;MkCuOVUxPyEQvF2= NYXXfHhCW0GQR1XS
K-562 NWDERmlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljGTWM2OD1{OD60NVg{KM7:TR?= NWXMXVJ5W0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

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In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

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  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+PEG300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms NVP-BEZ235

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01856101 Terminated Drug: BEZ235 Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Drug: BEZ235|Drug: Prednisone|Drug: Abiraterone acetate Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01756118 Unknown status Drug: BEZ235 Acute Lymphoblastic Leukemia|Leukemia Myelocytic Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells Johann Wolfgang Goethe University Hospital June 2012 Phase 1
NCT01290406 Withdrawn Drug: BEZ235 Endometrial Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01288092 Withdrawn Drug: BEZ235 Metastatic Breast Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01482156 Completed Drug: RAD001 + BEZ235 Advanced Solid Tumors|Metastatic Breast Cancer|Metastatic Renal Cell Carcinoma Novartis Pharmaceuticals|Novartis January 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID