Dactolisib (BEZ235)

For research use only.

Catalog No.S1009 Synonyms: NVP-BEZ235

335 publications

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.

Size Price Stock Quantity  
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Dactolisib (BEZ235) has been cited by 335 publications

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MXXBcpRqdWmlcn;ibYFtKEG|c3H5 NVjHOpR2OThiaB?= MkPGSG1UVw>? MWTBcpRqfHK7cHHuc5NwdWGuIHHjeIl3cXS7IIfpeIghTUN3MDDv[kAxNjByMkWg{txO NFj4THAzPDhyNUm0Oi=>
MCF7 M3XrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlToNE4xOS1zMECg{txO NXvlZlA4PDhiaB?= MlPkSG1UVw>? MmXXTWM2OD1yLkezJO69VQ>? MnK0NlM5PzF7MES=
HCT116 NYKxVHE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUWwMlAyNTFyMDFOwG0> NIjISXY1QCCq NGPaTplFVVOR M3\XVmlEPTB;MT6xOkDPxE1? M3X6XFI{QDdzOUC0
U87MG M320e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVeyd3VYOC5yMT2xNFAh|ryP MV20PEBp MmDjSG1UVw>? MWTJR|UxRTFwM{Kg{txO NVHP[40{OjN6N{G5NFQ>
HBC4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrWV49GOC5yMT2xNFAh|ryP NYW5RYxwPDhiaB?= NITWZZZNd2diR1m1NF0uQC54MTDN NXf0coxQOjJ|M{[yOFY>
BSY1 M{mzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPSTGxSOC5yMT2xNFAh|ryP MlzkOFghcA>? MnLUUI9oKEeLNUC9MVgvPDhiTR?= NEjCeIszOjN|NkK0Oi=>
HBC5 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfDNE4xOS1zMECg{txO Mn;uOFghcA>? MYrMc4chT0l3ME2tO{45PyCP MmfiNlI{OzZ{NE[=
MCF7 NVy4SVRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3qdYoxNjBzLUGwNEDPxE1? NXfXbJRMPDhiaB?= Ml\KUI9oKEeLNUC9MVgvOTZiTR?= MX6yNlM{PjJ2Nh?=
MDA-MB-231 NFvZWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTKNm5rOC5yMT2xNFAh|ryP NES1Umo1QCCq MUTMc4chT0l3ME2tPE4xQSCP MX6yNlM{PjJ2Nh?=
U251 NEnqbnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXVNE4xOS1zMECg{txO NVT2UGZYPDhiaB?= MWLMc4chT0l3ME2tO{43PiCP NFjPUpgzOjN|NkK0Oi=>
SF268 M1vuOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnSNE4xOS1zMECg{txO NU\3WJZ[PDhiaB?= NIfWc|RNd2diR1m1NF0uPy57MjDN NWD6cotkOjJ|M{[yOFY>
SF295 M1zGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml60NE4xOS1zMECg{txO MXi0PEBp NHHTTI5Nd2diR1m1NF0uQC5|MTDN MX[yNlM{PjJ2Nh?=
SF539 M2jyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSwMlAyNTFyMDFOwG0> Mn7BOFghcA>? NGXzWmNNd2diR1m1NF0uQC53OTDN NGrzRoIzOjN|NkK0Oi=>
SNB75 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWwMlAyNTFyMDFOwG0> NUDPbWVEPDhiaB?= NWPjS3ZZVG:pIFfJOVA:NThwNUigUS=> MnKwNlI{OzZ{NE[=
SNB78 NXnuSo86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnCOYl1OC5yMT2xNFAh|ryP MVe0PEBp MU\Mc4chT0l3ME2tPE43PSCP NVfhZ3lHOjJ|M{[yOFY>
HCC2998 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHXUGJ1OC5yMT2xNFAh|ryP M17jW|Q5KGh? NELhenRNd2diR1m1NF0uQC5yNTDN M4\2T|IzOzN4MkS2
KM12 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3KNE4xOS1zMECg{txO MYi0PEBp MkLMUI9oKEeLNUC9MVcvPTRiTR?= NHzPU5QzOjN|NkK0Oi=>
HT-29 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{S3e|AvODFvMUCwJO69VQ>? NX3iV|k4PDhiaB?= M4fPbmxw\yCJSUWwQU04Njd3IF2= M1PmO|IzOzN4MkS2
HCT15 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH5NE4xOS1zMECg{txO M1j3fFQ5KGh? M{nYb2xw\yCJSUWwQU05NjB|IF2= MXSyNlM{PjJ2Nh?=
HCT116 NW\V[mlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTFSIIyOC5yMT2xNFAh|ryP M3nScFQ5KGh? MlywUI9oKEeLNUC9MVcvPjFiTR?= MojvNlI{OzZ{NE[=
NCI-H23 Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmCyNE4xOS1zMECg{txO NGG3VWY1QCCq MmDDUI9oKEeLNUC9MVcvPjRiTR?= MnnmNlI{OzZ{NE[=
NCI-H226 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH4NE4xOS1zMECg{txO NHqzWJM1QCCq NGi0VJVNd2diR1m1NF0uQC52NDDN MoXsNlI{OzZ{NE[=
NCI-H522 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\Y[5ExNjBzLUGwNEDPxE1? M2XXNVQ5KGh? M1rRfGxw\yCJSUWwQU05NjR3IF2= MkTRNlI{OzZ{NE[=
NCI-H438 NXzJPJZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPDe3AxNjBzLUGwNEDPxE1? Mn\1OFghcA>? MmXKUI9oKEeLNUC9MVgvOTFiTR?= M2ruUVIzOzN4MkS2
A549 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHWVXIxNjBzLUGwNEDPxE1? MlnQOFghcA>? M1\sZmxw\yCJSUWwQU05NjB5IF2= NEPhXmUzOjN|NkK0Oi=>
DMS273 M2i3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[1e|AvODFvMUCwJO69VQ>? NULBW4N3PDhiaB?= NEnGbW5Nd2diR1m1NF0uPy56MDDN MnXWNlI{OzZ{NE[=
DMS114 NX3teWZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGUZp2OC5yMT2xNFAh|ryP NILaTms1QCCq MnPPUI9oKEeLNUC9MVgvOzliTR?= M3qyeFIzOzN4MkS2
LOXIMVI NVn5epZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;ENE4xOS1zMECg{txO NHnYcYY1QCCq MnfrUI9oKEeLNUC9MVgvPjZiTR?= MY[yNlM{PjJ2Nh?=
OVCAR3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCwMlAyNTFyMDFOwG0> NXTWeJR7PDhiaB?= NFzhOVNNd2diR1m1NF0uQC5zNzDN NVTTN|I3OjJ|M{[yOFY>
OVCAR4 M1vHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2O4XlAvODFvMUCwJO69VQ>? NWrRTmc4PDhiaB?= Mn75UI9oKEeLNUC9MVgvPThiTR?= NYLsOllpOjJ|M{[yOFY>
OVCAR5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLlNE4xOS1zMECg{txO NVLNRoh{PDhiaB?= MYLMc4chT0l3ME2tO{42PyCP NIq3ZZozOjN|NkK0Oi=>
OVCAR8 NIXFO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvTc5M1OC5yMT2xNFAh|ryP MVO0PEBp NIHSfVNNd2diR1m1NF0uPy56NDDN NXW0cHZ{OjJ|M{[yOFY>
SKOV3 NYn4cmMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC2NE4xOS1zMECg{txO NU\pPZVqPDhiaB?= MWHMc4chT0l3ME2tPE41OSCP NVPnc|NiOjJ|M{[yOFY>
RXF631L MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHIUXUxNjBzLUGwNEDPxE1? M{exW|Q5KGh? NIHpTVFNd2diR1m1NF0uQC5{MTDN NU\6R4t3OjJ|M{[yOFY>
ACHN MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPYNE4xOS1zMECg{txO M3TuSFQ5KGh? MUnMc4chT0l3ME2tO{46PSCP NFTYNmczOjN|NkK0Oi=>
St-4 Mn\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rDelAvODFvMUCwJO69VQ>? MnHzOFghcA>? MVfMc4chT0l3ME2tO{41PyCP NV7wTGlMOjJ|M{[yOFY>
MKN1 NEH3TnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO3fYlvOC5yMT2xNFAh|ryP NYjKO3ZRPDhiaB?= MV3Mc4chT0l3ME2tPE41OSCP NWLqe|ZoOjJ|M{[yOFY>
MKN7 M1TxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLWNE4xOS1zMECg{txO MmfsOFghcA>? MVXMc4chT0l3ME2tO{43QCCP NXLtU4J5OjJ|M{[yOFY>
MKN28 NGfVT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorMNE4xOS1zMECg{txO MXq0PEBp NIn1VVZNd2diR1m1NF0uPy5yNzDN MoXvNlI{OzZ{NE[=
MKN45 MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV[wMlAyNTFyMDFOwG0> NULP[2s3PDhiaB?= NIfTe3JNd2diR1m1NF0uQC5|NDDN MmDWNlI{OzZ{NE[=
MKN74 NYizS4VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\1doIxNjBzLUGwNEDPxE1? NIPlNWk1QCCq NHvQTpJNd2diR1m1NF0uPy52MjDN NVXpNGxoOjJ|M{[yOFY>
DU145 M3K5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnSNE4xOS1zMECg{txO MlnVOFghcA>? M3:1fWxw\yCJSUWwQU05NjF4IF2= MlLINlI{OzZ{NE[=
PC3 M1i4Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW0c2gxNjBzLUGwNEDPxE1? NI\NZVk1QCCq MYfMc4chT0l3ME2tPE43PiCP NH;BNmQzOjN|NkK0Oi=>
Trypanosoma brucei brucei M1f4RmZ2dmO2aX;uJGF{e2G7 MkiyNlAxKG6P NYf5fYw{OTJiaB?= MUnEUXNQ NYD0dYZoTGWlcnXhd4UhcW5icHjvd5Bpd3SrZInsJIlvd3OrdH;sJJBpd3OyaHH0[UBt\X[nbB?= NIrXdHozPDhyNUm0Oi=>
Trypanosoma brucei brucei NXjVe3JMTnWwY4Tpc44hSXO|YYm= M1jjdVE5KGh? NF22bFdFVVOR NFL0THBKdmirYnn0bY9vKG:oIILlZ4VxfG:{LX3l[IlifGWmIHXu[I9kgXSxc3nzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIITyZY5{\mW{cnnuJJVxfGGtZR?= MkTNNlQ5ODV7NE[=
Trypanosoma brucei brucei MXvGeY5kfGmxbjDBd5NigQ>? MUKyNFAhdk1? MUexNkBp NVfxNWNjTE2VTx?= Mme2SYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> M2XUUlI1QDB3OUS2
Trypanosoma brucei brucei M1fwOWZ2dmO2aX;uJGF{e2G7 NXHBTIxwOjByIH7N MVixNkBp M3fme2ROW09? MmKySYZn\WO2IH;uJJBpd3OyaHH0bYR6dGOqb3zpcoUhdGW4ZXy= NUjEW4l2OjR6MEW5OFY>
UM-UC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XFfGlEPTB;M{G1JJBO NGnme4xUSU6JRWK=
SBC-1 NFH3VVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3n0NmlEPTB;N{SyJJBO NYLYdoRZW0GQR1XS
MKN1 M3fyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGyTWM2OD1{Lkigcm0> NHfBeGhUSU6JRWK=
NCI-H720 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHJVGg2UUN3ME2zMlU4KG6P M{jSNXNCVkeHUh?=
BFTC-909 NHKxRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rmNmlEPTB;Mz63NUBvVQ>? M4f3OnNCVkeHUh?=
BPH-1 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y2VGlEPTB;ND63OkBvVQ>? NV\ZW5ZvW0GQR1XS
PC-3 NIO3cmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi0TWM2OD13LkC5JI5O Ml3sV2FPT0WU
AN3-CA MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoKzTWM2OD13LkW2JI5O MVjTRW5ITVJ?
HN NGDJWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTsUG9XUUN3ME21Mlk3KG6P NUmw[XFlW0GQR1XS
HCC2218 NWjsfGdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7EZ5NrUUN3ME22MlYyKG6P MkLPV2FPT0WU
KP-4 MkXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPnTWM2OD15IH7N NFjXO|RUSU6JRWK=
LU-139 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInLe29KSzVyPUeuO|chdk1? MonYV2FPT0WU
ETK-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi2SIVKUUN3ME23Mlg5KG6P NHTEUpBUSU6JRWK=
Ramos-2G6-4C10 NGf1bXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRThwNEmgcm0> MmHpV2FPT0WU
MHH-PREB-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTlwMUKgcm0> NYS1d|l6W0GQR1XS
DU-4475 NEnGRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTlwNESgcm0> MXzTRW5ITVJ?
NCI-H1666 NFHteZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXG3ZZh5UUN3ME25MlcyKG6P NIXyVW9USU6JRWK=
CAMA-1 NXqzfJB2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDX[Y1KSzVyPUmuPEBvVQ>? NEXWdJpUSU6JRWK=
TYK-nu MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LKfWlEPTB;OT65OEBvVQ>? MWfTRW5ITVJ?
MFE-280 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYS1cY5wUUN3ME25Mlk6KG6P MWXTRW5ITVJ?
A549 NXi1e2NjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXjWnFKSzVyPUGwMlE1KG6P NXnWd2FpW0GQR1XS
769-P MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXmcnZKSzVyPUGwMlQ1KG6P M{TXW3NCVkeHUh?=
L-363 NH7OS41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnXR2JKSzVyPUGwMlY6KG6P MoD6V2FPT0WU
ES8 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;ZT2lKSzVyPUGwMlkhdk1? MmG3V2FPT0WU
PA-1 NIH1[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD6TWM2OD1zMT64NkBvVQ>? M2TKfXNCVkeHUh?=
Mewo NUDaeod3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmzTWM2OD1zMT65PUBvVQ>? NXrNVXJxW0GQR1XS
HSC-3 M3LOd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorWTWM2OD1zMj6yNUBvVQ>? NWTwZYhoW0GQR1XS
H4 NUjQSHd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF{Lk[3JI5O NULBR2tzW0GQR1XS
BB65-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;rb4RKSzVyPUGyMlczKG6P MVjTRW5ITVJ?
NCI-H1793 NETrb|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLDNnFbUUN3ME2xNk45OiCwTR?= MV7TRW5ITVJ?
KARPAS-45 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP0do5OUUN3ME2xN{42OSCwTR?= NHjTPI9USU6JRWK=
GCT NG[2T|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTF|Lk[4JI5O MkfSV2FPT0WU
EoL-1 M3O0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF|LkmzJI5O MXnTRW5ITVJ?
LB2241-RCC M3TmWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLG[5BKSzVyPUG0MlAyKG6P NGDXVmRUSU6JRWK=
ES5 MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\xTWM2OD1zND63OEBvVQ>? MXTTRW5ITVJ?
LOXIMVI M4PCdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF2Lkm5JI5O MVPTRW5ITVJ?
COR-L105 NGLKZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXofZVkUUN3ME2xOU4xPCCwTR?= MoDGV2FPT0WU
P12-ICHIKAWA M3L0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTF3LkGgcm0> M1fnZ3NCVkeHUh?=
CHL-1 M3mzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jlT2lEPTB;MUWuOFUhdk1? NXWyPZR4W0GQR1XS
VMRC-RCZ M13ZXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF3Lk[zJI5O Mm\kV2FPT0WU
HH NXnNVot7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ewemlEPTB;MUWuO{BvVQ>? MUjTRW5ITVJ?
NUGC-3 NWfDWo1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFGybnZKSzVyPUG2MlM1KG6P MmXIV2FPT0WU
EGI-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF4LkSzJI5O M3TKW3NCVkeHUh?=
OS-RC-2 NH70fJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF4LkS3JI5O MnnPV2FPT0WU
MOLT-16 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT1TWM2OD1zNz6xOUBvVQ>? M{PpO3NCVkeHUh?=
NCI-H209 NVjlXZNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XBZmlEPTB;MUeuNlkhdk1? NX3LRYdEW0GQR1XS
697 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm1W3RKSzVyPUG3MlQ{KG6P NVLSW5VLW0GQR1XS
D-56MG M4X2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTF5Lk[5JI5O NYnMTY95W0GQR1XS
VA-ES-BJ MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTF5LkizJI5O MXPTRW5ITVJ?
EW-16 M{jUN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF6LkC0JI5O NF7D[ZlUSU6JRWK=
HGC-27 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrvTWM2OD1zOD6wOkBvVQ>? MX7TRW5ITVJ?
ES7 MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzZTWM2OD1zOD6wPUBvVQ>? M2PW[HNCVkeHUh?=
HuH-7 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfMXYpNUUN3ME2xPE41KG6P NFvmbVZUSU6JRWK=
BCPAP NGTGOJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\6[YpKSzVyPUG4MlY2KG6P MUjTRW5ITVJ?
SW1710 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvsTWM2OD1zOD63NkBvVQ>? NYe5emlMW0GQR1XS
IST-MEL1 NYDMdm5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD1[mNyUUN3ME2xPE44PyCwTR?= NWnYSpBYW0GQR1XS
SF295 NIrhe5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX6TWM2OD1zOD65N{BvVQ>? MoXuV2FPT0WU
RPMI-7951 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGeyN25KSzVyPUG5MlI5KG6P NV7ZOIliW0GQR1XS
SF126 NHfVPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF7LkSxJI5O MWnTRW5ITVJ?
GAMG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF7LkS4JI5O MW\TRW5ITVJ?
KNS-81-FD MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTF7LkW0JI5O MYHTRW5ITVJ?
RT-112 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF7Lk[2JI5O MXHTRW5ITVJ?
DEL NYG3eVNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP4TWM2OD1{MD60PUBvVQ>? M{TVVXNCVkeHUh?=
CGTH-W-1 Mnf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPVdXRKSzVyPUKwMlY{KG6P NV3jUm06W0GQR1XS
HOS NEDLSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJzLkC2JI5O NV\YfmJqW0GQR1XS
ES4 NVK0W5AzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjuOI1QUUN3ME2yNU4xQCCwTR?= MoH0V2FPT0WU
RXF393 NEjHbI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJzLkS1JI5O NX\T[og4W0GQR1XS
NCI-H2030 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4TWM2OD1{MT61NkBvVQ>? MkTUV2FPT0WU
YH-13 NGLOWIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDtTWM2OD1{MT64PEBvVQ>? MWLTRW5ITVJ?
HT-1080 M3z4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJzLkmzJI5O NWj5N4txW0GQR1XS
NCI-SNU-1 NGHL[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJzLkm1JI5O NVewNG1CW0GQR1XS
G-402 NF7KSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfBdYNrUUN3ME2yNk4yPiCwTR?= M4HlZ3NCVkeHUh?=
786-0 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TzeGlEPTB;MkKuNlkhdk1? MY\TRW5ITVJ?
ME-180 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzVTWM2OD1{Mj60N{BvVQ>? NGDBTWRUSU6JRWK=
NB69 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ{LkWzJI5O MkXQV2FPT0WU
J-RT3-T3-5 NUOxdppFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3POd2lEPTB;MkKuPVYhdk1? MYHTRW5ITVJ?
TGBC1TKB NVvobldTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPhfVloUUN3ME2yN{4xPSCwTR?= MW\TRW5ITVJ?
SW780 M3;XRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi2TZVlUUN3ME2yN{4yOyCwTR?= NVjMW4FZW0GQR1XS
MG-63 M{\TWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD5fpdkUUN3ME2yN{41PSCwTR?= NWnRNGFLW0GQR1XS
BV-173 NH\kSJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHraclhKSzVyPUKzMlg4KG6P MlXGV2FPT0WU
CAL-51 NUC4SlVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;sSYt1UUN3ME2yN{45QSCwTR?= NIr0ZYZUSU6JRWK=
A375 M4rKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ETWM2OD1{Mz65N{BvVQ>? NFXnRXZUSU6JRWK=
MEL-HO MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\yPVNnUUN3ME2yOE4xPCCwTR?= MWDTRW5ITVJ?
EFO-27 NFvOV45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7JWmc4UUN3ME2yOE4{OyCwTR?= MmrsV2FPT0WU
Hs-578-T NVzPW4tGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWyNYdKSzVyPUK0MlU5KG6P NEDmR|hUSU6JRWK=
NBsusSR NYS0PJc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJ2Lk[gcm0> MoK5V2FPT0WU
CTB-1 Mn;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXSU4tKSzVyPUK0MlY4KG6P Mo\mV2FPT0WU
FTC-133 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTJ3LkGgcm0> MnPFV2FPT0WU
MOLT-4 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\we3NKSzVyPUK1MlEzKG6P NETwSldUSU6JRWK=
HO-1-N-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TrT2lEPTB;MkWuNVUhdk1? NUDYXJZFW0GQR1XS
ES3 NHfsVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqyfWZKUUN3ME2yOU4zOiCwTR?= NV3YZ2tyW0GQR1XS
TI-73 M4fvTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLKPXRNUUN3ME2yOU4zQCCwTR?= NIW0OY9USU6JRWK=
MPP-89 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLiO4xKSzVyPUK1MlMzKG6P MXnTRW5ITVJ?
KYSE-150 M2HvOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7HNYlKSzVyPUK1Mlg6KG6P NXrQVWJSW0GQR1XS
LXF-289 NGX2VIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\URYpsUUN3ME2yOk4xPCCwTR?= M3TJZ3NCVkeHUh?=
SK-LU-1 NGG4c2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfvW41KSzVyPUK2MlE4KG6P NWjrdlZFW0GQR1XS
HOP-92 NWPuN|NDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i0OWlEPTB;Mk[uOFghdk1? M3m4VHNCVkeHUh?=
HuO9 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTJ4Lke2JI5O NXfYTnB6W0GQR1XS
SW962 MlvpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJ4Lke2JI5O NVT1[od6W0GQR1XS
RS4-11 M16wOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;scWlEPTB;Mk[uPVEhdk1? MULTRW5ITVJ?
NCI-H292 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTJ5IH7N MXjTRW5ITVJ?
DB NFnSOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3yTWM2OD1{Nz6zOkBvVQ>? M1yzRXNCVkeHUh?=
SW1088 NIDSWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37qUWlEPTB;MkiuNlkhdk1? M1LvdXNCVkeHUh?=
A204 NVPGWWlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\6UVBKSzVyPUK4MlQ4KG6P NF;1W2pUSU6JRWK=
A3-KAW M2nyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK1VG9KSzVyPUK4MlY1KG6P NG[5b5FUSU6JRWK=
MV-4-11 NYPq[XM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvEVVdKSzVyPUK4Mlchdk1? NYj0OJRRW0GQR1XS
ES1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LSdGlEPTB;MkiuPFQhdk1? NIjTZ4NUSU6JRWK=
ONS-76 M{G2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJ7LkC1JI5O M4n1Z3NCVkeHUh?=
D-263MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT1VXNnUUN3ME2yPU4{PSCwTR?= NIjuc3NUSU6JRWK=
U-2-OS MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ7LkWgcm0> MYLTRW5ITVJ?
T98G NUPhcWs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETPVZFKSzVyPUK5Mlg5KG6P NFTMZnJUSU6JRWK=
GI-ME-N MmfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HJRWlEPTB;MkmuPVEhdk1? MkLJV2FPT0WU
BHT-101 M3;6eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrRTWM2OD1|MD6wOUBvVQ>? MojUV2FPT0WU
NOS-1 NVLZTJdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNyLkGyJI5O NIrSc5RUSU6JRWK=
AsPC-1 M13EW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTNyLkKgcm0> MorVV2FPT0WU
QIMR-WIL NFrw[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnMPJBkUUN3ME2zNE43KG6P MmqxV2FPT0WU
JVM-3 NEXheIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrFTWM2OD1|MD64N{BvVQ>? NGjxeI9USU6JRWK=
KU-19-19 M333V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPoTWM2OD1|MT6xN{BvVQ>? NX\IPFdpW0GQR1XS
OVCAR-8 NIDIVJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGqwVZFKSzVyPUOxMlI3KG6P Ml:5V2FPT0WU
BEN MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrkbohKSzVyPUOxMlY{KG6P MnrQV2FPT0WU
BE-13 NGHxc2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfnTWM2OD1|MT64NkBvVQ>? NFnneVdUSU6JRWK=
EW-18 NYqwdZFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH4TItIUUN3ME2zNU45PiCwTR?= MWDTRW5ITVJ?
ECC10 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW2fnJKSzVyPUOxMlk2KG6P MofhV2FPT0WU
CTV-1 NVLncXhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnTT3NKSzVyPUOyMlgzKG6P MXzTRW5ITVJ?
COLO-800 NILxWnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlyyTWM2OD1|Mj65NkBvVQ>? NVj6bo9uW0GQR1XS
A2058 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTBTWM2OD1|Mz6yOUBvVQ>? NWjQW5Q5W0GQR1XS
VM-CUB-1 NInBW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzuTWM2OD1|Mz60N{BvVQ>? NXOxVFNlW0GQR1XS
Ca9-22 NGDQXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH0TWM2OD1|Mz61OUBvVQ>? MYfTRW5ITVJ?
COLO-684 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfmVXJKSzVyPUOzMlU5KG6P NV35e2F4W0GQR1XS
RPMI-8226 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDjUHFKSzVyPUOzMlgzKG6P MYfTRW5ITVJ?
SK-NEP-1 NIHTV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HnU2lEPTB;M{SuNVUhdk1? NYXOflhsW0GQR1XS
Becker MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTN2LkKxJI5O NWPpWnBQW0GQR1XS
NCI-H28 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnUWWM{UUN3ME2zOE41PCCwTR?= MoLGV2FPT0WU
CAL-120 NYDodWQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTN2LkeyJI5O NX3EbpYxW0GQR1XS
MDA-MB-157 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTN3LkSxJI5O MmLlV2FPT0WU
OVCAR-5 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PKZ2lEPTB;M{WuOFchdk1? NFrsUG5USU6JRWK=
LAMA-84 NFjhU4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfKPZVKSzVyPUO1Mlg4KG6P NXXqOWZQW0GQR1XS
CAKI-1 NWK0UnA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnUSpBKSzVyPUO2MlQ{KG6P MUfTRW5ITVJ?
Daoy M2nIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3UfmNKSzVyPUO2Mlchdk1? M3jpT3NCVkeHUh?=
CAL-62 NWLFWWNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LFO2lEPTB;M{[uPFYhdk1? MnHLV2FPT0WU
8-MG-BA Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHr2SZVKSzVyPUO3MlI2KG6P MmjzV2FPT0WU
8505C NYXBW|M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;UdmJKSzVyPUO3MlUyKG6P NXvnOG5oW0GQR1XS
LNCaP-Clone-FGC MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInDUXRKSzVyPUO3MlU6KG6P NF:2SI5USU6JRWK=
CAL-39 NFXWV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH1bJRKSzVyPUO3Mlkhdk1? MXfTRW5ITVJ?
MN-60 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkGxTWM2OD1|Nz65OkBvVQ>? NEDWbZFUSU6JRWK=
RKO NXnETYpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\JV|dVUUN3ME2zPE4{OyCwTR?= NYTPUmduW0GQR1XS
U251 M3viemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXGemtZUUN3ME2zPE41OyCwTR?= NE[4TmNUSU6JRWK=
SJSA-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj1cWl4UUN3ME2zPE42PCCwTR?= NHz2eGVUSU6JRWK=
CAL-12T MkHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn5PGhKSzVyPUO4MlYhdk1? MVzTRW5ITVJ?
HCC1419 NVizcIlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTN6LkexJI5O MUDTRW5ITVJ?
CO-314 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTsVHRHUUN3ME2zPE44PCCwTR?= MnjiV2FPT0WU
LB1047-RCC NVLGUXU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2q4XGlEPTB;M{iuPFEhdk1? NVTGcnI3W0GQR1XS
A101D NFrZSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTN6Lkm3JI5O NUPYNYVLW0GQR1XS
MDA-MB-175-VII NXTENppUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWqw[XJUUUN3ME2zPU42OSCwTR?= NFGwOIZUSU6JRWK=
MZ2-MEL M{HsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlL4TWM2OD1|OT62OkBvVQ>? NF7yZm1USU6JRWK=
NB5 NXHxbGpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTGTWM2OD12MD62OEBvVQ>? NIroeXNUSU6JRWK=
G-401 M37hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTRyLkiyJI5O Mnv5V2FPT0WU
HT MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPURZdKSzVyPUSxMlAzKG6P NH7wO2xUSU6JRWK=
8305C M2nSW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1myT2lEPTB;NEGuPFchdk1? MljpV2FPT0WU
BHY M{fqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G3UmlEPTB;NEKuO|Ihdk1? M2DvXnNCVkeHUh?=
NTERA-S-cl-D1 NXewfI1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTR|IH7N MlTHV2FPT0WU
T-24 M3HlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvFPWQ2UUN3ME20N{45OyCwTR?= MXfTRW5ITVJ?
EPLC-272H MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfyN2dKSzVyPUS0MlM6KG6P M2rFVHNCVkeHUh?=
PSN1 MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorMTWM2OD12ND60JI5O NGDQR5dUSU6JRWK=
NCI-H2452 NIf6ToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nPW2lEPTB;NESuOVghdk1? MmfVV2FPT0WU
KS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\6c4VKSzVyPUS0MlY3KG6P MYHTRW5ITVJ?
HD-MY-Z MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml36TWM2OD12ND65NkBvVQ>? NFjDcmxUSU6JRWK=
KNS-62 MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmqwTWM2OD12NT6zPEBvVQ>? NHPqUZVUSU6JRWK=
NOMO-1 NHza[3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlryTWM2OD12NT64O{BvVQ>? NX[yVmlSW0GQR1XS
SK-HEP-1 NVzybopOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnwTWM2OD12Nj6wOEBvVQ>? Mn7vV2FPT0WU
IGR-1 NIPXU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1uwNWlEPTB;NE[uNVMhdk1? M4rRRXNCVkeHUh?=
KYSE-180 MnLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPITWM2OD12Nj6xO{BvVQ>? NF;PWohUSU6JRWK=
EW-22 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYG1W3BTUUN3ME20Ok4zKG6P NGLxTVhUSU6JRWK=
NCI-H1355 M1i1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLQNIFKSzVyPUS2MlM1KG6P M3rKcXNCVkeHUh?=
DOHH-2 MlrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTGTWM2OD12Nj6zO{BvVQ>? MoHIV2FPT0WU
A4-Fuk MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnCfoV7UUN3ME20Ok42OiCwTR?= NInJ[2FUSU6JRWK=
PC-14 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPNTWM2OD12Nj61O{BvVQ>? MWrTRW5ITVJ?
TE-5 NIO3cpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnGTWM2OD12Nj64OEBvVQ>? MYnTRW5ITVJ?
LB996-RCC NV\TOZdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PKO2lEPTB;NEeuNVkhdk1? MmP2V2FPT0WU
NCI-H1623 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rBXGlEPTB;NEeuO|Yhdk1? NIT0UpZUSU6JRWK=
NCI-H1155 Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTR6LkOyJI5O Mn74V2FPT0WU
LoVo MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfsOHBKSzVyPUS4MlQhdk1? NUPr[JY3W0GQR1XS
MCF7 Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLmTWM2OD12OD61PEBvVQ>? NEmwWlNUSU6JRWK=
AGS MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XveGlEPTB;NEiuO|chdk1? M2DMUHNCVkeHUh?=
PFSK-1 M3n2Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPmclBzUUN3ME20PU4xPiCwTR?= NWfMN|c{W0GQR1XS
22RV1 NH\NeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\jbHdtUUN3ME20PU4xQSCwTR?= MYfTRW5ITVJ?
COR-L23 NFPxXolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13nUmlEPTB;NEmuNVYhdk1? MoHVV2FPT0WU
D-283MED NGXFZ|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPSbHJKSzVyPUS5MlYyKG6P MlnGV2FPT0WU
SW982 NXTsVHdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrqbHpKSzVyPUS5MlkyKG6P NY\1V|NqW0GQR1XS
SW620 NXnMVFY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPWPVIzUUN3ME21NE4{PiCwTR?= M2m0VXNCVkeHUh?=
KYSE-140 M4X4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPjR2RkUUN3ME21NE42PSCwTR?= NUi1dmNJW0GQR1XS
GCIY M2TtSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrvTWM2OD13MD62O{BvVQ>? NV3Y[nFYW0GQR1XS
MHH-ESS-1 MnHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnkTWM2OD13MT65OUBvVQ>? NVXMc2NzW0GQR1XS
D-423MG NH\CSGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnhT2ZKSzVyPUWyMlA5KG6P NF7TcFhUSU6JRWK=
SF539 NUXNO214T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOwcHdKSzVyPUWyMlM2KG6P M3;MVnNCVkeHUh?=
RPMI-2650 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTV{Lk[5JI5O NV7NbG5EW0GQR1XS
GR-ST MlmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf2WY57UUN3ME21Nk45PyCwTR?= MXjTRW5ITVJ?
YKG-1 NGLHO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjiTWM2OD13MzDuUS=> NIXydWZUSU6JRWK=
SK-MES-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\CWWlEPTB;NUOuNlYhdk1? NIT2PXFUSU6JRWK=
HLE MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrROnFKSzVyPUWzMlQ4KG6P MVLTRW5ITVJ?
RVH-421 M{KwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT2VlRuUUN3ME21N{43PyCwTR?= NYfWR4M2W0GQR1XS
C32 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfFcpc5UUN3ME21N{45OyCwTR?= NGrEdWtUSU6JRWK=
GB-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TiNmlEPTB;NUSuNkBvVQ>? MkDPV2FPT0WU
SNB75 NUXLVWFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXpRZFKSzVyPUW0MlI3KG6P NWC5UYFGW0GQR1XS
EM-2 NXfRT49QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX61Z4p2UUN3ME21OE41KG6P MWrTRW5ITVJ?
RH-1 NVX0dGVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf2NIRKSzVyPUW0Mlchdk1? Mn;PV2FPT0WU
NKM-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fBeGlEPTB;NUSuPFEhdk1? M2OydHNCVkeHUh?=
NCI-H2405 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33kZ2lEPTB;NUSuPFghdk1? NIKzN2lUSU6JRWK=
KYSE-450 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrWTWM2OD13NT6xOkBvVQ>? NH;0O2lUSU6JRWK=
A704 M3jCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTV3LkW5JI5O MmTlV2FPT0WU
HAL-01 NV3zRWRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofTTWM2OD13NT64N{BvVQ>? MUfTRW5ITVJ?
TE-11 NFzIPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTV3Lkm5JI5O NHzDXG1USU6JRWK=
DOK NV7WU2xCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PFRWlEPTB;NU[uNFIhdk1? M3WxfnNCVkeHUh?=
KY821 NXewTpNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzON4dCUUN3ME21Ok4zKG6P M3\BVXNCVkeHUh?=
KGN NFHMPZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTV4LkOyJI5O M3Gxc3NCVkeHUh?=
MC116 M1LaV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXewS5FYUUN3ME21O{45KG6P NGnQUZBUSU6JRWK=
PANC-08-13 NUXtSJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTV6LkCxJI5O MnzCV2FPT0WU
KE-37 NWH1[HVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTV6Lke3JI5O NHTkTWZUSU6JRWK=
KYSE-410 NYm0NoxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTV7LkS3JI5O MmfmV2FPT0WU
RO82-W-1 M4LReWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTV7Lkmgcm0> M1rUVXNCVkeHUh?=
M14 M3TQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjtPFRWUUN3ME22NE4xPCCwTR?= M1rGWHNCVkeHUh?=
GI-1 NF;DR4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\2bmlEPTB;NkCuN{BvVQ>? Mn\KV2FPT0WU
ML-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHUTWM2OD14MD62NkBvVQ>? NWixU|QzW0GQR1XS
BFTC-905 M3vwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LN[mlEPTB;NkCuOlUhdk1? M3u1XHNCVkeHUh?=
DMS-273 MmfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTZyLki3JI5O NV[0UmhlW0GQR1XS
MDA-MB-361 NGHmVIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTZzIH7N M3TCNHNCVkeHUh?=
MSTO-211H MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\0SHFKUUN3ME22N{42OSCwTR?= M4LHWHNCVkeHUh?=
MEG-01 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTZ|LkWyJI5O M4DGeHNCVkeHUh?=
M059J MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C4OWlEPTB;NkOuOVghdk1? M4flNnNCVkeHUh?=
LN-405 NGO3cZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fC[2lEPTB;NkOuPFUhdk1? M3j2TXNCVkeHUh?=
NCI-H1581 MnPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWL3R5RDUUN3ME22OE4xOyCwTR?= NFmyd4xUSU6JRWK=
TCCSUP NFz0eHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjVT5VDUUN3ME22OE42OyCwTR?= MYXTRW5ITVJ?
SW872 NULufXRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nLNmlEPTB;NkSuOVchdk1? NGHpOFJUSU6JRWK=
KYSE-510 M2n3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHjTWM2OD14NT63OUBvVQ>? MlPOV2FPT0WU
NCI-H1792 NIrzWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DOfGlEPTB;Nk[uNVUhdk1? NEDibm5USU6JRWK=
SW13 NF;yVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\SfmlEPTB;Nk[uOUBvVQ>? MkGwV2FPT0WU
TE-8 NVLyT5NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1KzV2lEPTB;Nk[uOVIhdk1? M1vpOXNCVkeHUh?=
SCH NYLDNm1jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjXW4FKSzVyPU[3MlEhdk1? Mnj2V2FPT0WU
NEC8 M2C1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnBU4dnUUN3ME22O{4zPCCwTR?= NW[4dVlEW0GQR1XS
HuO-3N1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX25TGlzUUN3ME22O{4{OSCwTR?= M1:4cXNCVkeHUh?=
EFM-19 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTZ5LkWgcm0> Mo\5V2FPT0WU
HEC-1 NHPaXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTZ5LkWyJI5O MX;TRW5ITVJ?
T47D M{HEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjSXmtKSzVyPU[3Mlg4KG6P MmHTV2FPT0WU
SNU-423 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy0e4FTUUN3ME22O{46QCCwTR?= NYLXR5VoW0GQR1XS
WM-115 MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHQcYFKSzVyPU[4MlE1KG6P NGLtUnNUSU6JRWK=
CaR-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTZ6LkK1JI5O NU\HRlBSW0GQR1XS
KU812 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTWUXFlUUN3ME22PE43QSCwTR?= MlLFV2FPT0WU
AM-38 NHXjTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTZ7LkOxJI5O NUXVelF4W0GQR1XS
KOSC-2 NEfXTIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS0PHhKSzVyPU[5Mlk4KG6P MVfTRW5ITVJ?
MC-IXC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTdyLkC4JI5O MmjDV2FPT0WU
SCC-4 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvQS5FKSzVyPUexMlM5KG6P NVvMU21bW0GQR1XS
Calu-3 NXTFOXVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfkTWM2OD15MT65PEBvVQ>? NVrwUJBQW0GQR1XS
RPMI-8866 NVHhOmNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkH0TWM2OD15Mj64NkBvVQ>? MlXaV2FPT0WU
OVCAR-4 NYPoOZVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnTTWM2OD15Mz6zOkBvVQ>? NIjH[pRUSU6JRWK=
OAW-42 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvEcnBKSzVyPUezMlM6KG6P MVHTRW5ITVJ?
ATN-1 NIC3SHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvOXmRKSzVyPUezMlg4KG6P NUXSPG5xW0GQR1XS
CHP-212 M3LMcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nZd2lEPTB;N{SuPVUhdk1? MV;TRW5ITVJ?
C2BBe1 NVjqUo9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPIWIMyUUN3ME23OU4xOyCwTR?= MV\TRW5ITVJ?
A498 NX\WfXJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH0bWFKSzVyPUe1MlE2KG6P NXvqSGl3W0GQR1XS
SH-4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTd3LkKxJI5O MlrTV2FPT0WU
SNU-449 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUf5[IE{UUN3ME23OU44QSCwTR?= NVHSN3FTW0GQR1XS
RD NUDDcHgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHPTWM2OD15NT64OkBvVQ>? MmLvV2FPT0WU
PANC-03-27 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTd4LkK1JI5O M4jCUXNCVkeHUh?=
S-117 NIfMPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSzfJloUUN3ME23Ok4zPyCwTR?= NFvkSJBUSU6JRWK=
SK-MEL-2 NGDsVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnnWZlKSzVyPUe2Mlc2KG6P NHTJTVBUSU6JRWK=
LK-2 M{TXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTd5LkC1JI5O NV3MXIt2W0GQR1XS
CP50-MEL-B MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HkfWlEPTB;N{euOEBvVQ>? NGfuTYtUSU6JRWK=
647-V MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjqTWM2OD15OD6wO{BvVQ>? NYH6U4MyW0GQR1XS
LU-134-A NVK1UYRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\5VmlEPTB;N{muNFMhdk1? MmrSV2FPT0WU
5637 M{f5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7CTWM2OD15OT6yN{BvVQ>? MmC0V2FPT0WU
NCI-H1437 M2XWUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrhbpZKSzVyPUiwMlUhdk1? NGSwfG1USU6JRWK=
NCI-H460 NEnCdJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1H0SGlEPTB;OEGuNlMhdk1? NWHLWWhKW0GQR1XS
BxPC-3 NXTzdld7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP0UWNKSzVyPUixMlQ3KG6P NHzqN5pUSU6JRWK=
CAN MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPFPI85UUN3ME24NU45PCCwTR?= NWnrVYdtW0GQR1XS
KINGS-1 NUTnSJdwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS2bZJrUUN3ME24Nk4{OiCwTR?= NHHFWlhUSU6JRWK=
OCUB-M MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfMRXNtUUN3ME24Nk41OSCwTR?= NYX5SINiW0GQR1XS
KALS-1 NIXjSG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDGZ4xiUUN3ME24Nk42PCCwTR?= MkfsV2FPT0WU
OCI-AML2 M1fMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKyOYt{UUN3ME24Nk43OSCwTR?= NFL4ZXFUSU6JRWK=
A253 M3;GS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj5d|dKSzVyPUiyMlY2KG6P Mn70V2FPT0WU
LCLC-97TM1 NXvobok1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvRTWM2OD16Mj64OkBvVQ>? NYraSHVrW0GQR1XS
NCI-H520 M2jmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\3cIp2UUN3ME24N{4xPiCwTR?= MV3TRW5ITVJ?
P30-OHK MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XDTGlEPTB;OEOuOUBvVQ>? Ml\rV2FPT0WU
SBC-5 MmXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPzfmdKSzVyPUizMlUzKG6P MV3TRW5ITVJ?
HCE-T MnniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TJZmlEPTB;OEOuO|Qhdk1? NVfWb5duW0GQR1XS
JEG-3 M4DEe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLrXnYzUUN3ME24OE4yKG6P Mk\YV2FPT0WU
KG-1 NV7WcZBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;BTWM2OD16ND6yOEBvVQ>? NUTMSFlMW0GQR1XS
MIA-PaCa-2 NGfydHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzEOpFKSzVyPUi0MlU1KG6P M2XmUnNCVkeHUh?=
CAL-33 M1HXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjOVmVKSzVyPUi1MlA5KG6P NX\K[5dqW0GQR1XS
639-V NFPnbo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\sTWM2OD16NT60NkBvVQ>? M3Xsd3NCVkeHUh?=
NCI-H1048 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTh4LkOxJI5O MYPTRW5ITVJ?
NCI-H1573 M2Pmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuzTWM2OD16Nz60PEBvVQ>? NV7HZ5FFW0GQR1XS
NCI-H2228 NWTkdG5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTh6LkK2JI5O M4ni[HNCVkeHUh?=
NB14 NG\XUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnqRpVtUUN3ME24PE4{KG6P NXXIUZZtW0GQR1XS
SCC-25 M4XIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTWTWM2OD16OT64NkBvVQ>? NH7KXGFUSU6JRWK=
A431 NWnveXg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PKSmlEPTB;OEmuPVchdk1? NVSyUYIzW0GQR1XS
SN12C MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT2boZKSzVyPUmwMlYzKG6P NFnNToZUSU6JRWK=
HuCCT1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrYNZQ5UUN3ME25NE44PiCwTR?= Mlm4V2FPT0WU
LS-123 M{i4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTl{LkG4JI5O M1fWbnNCVkeHUh?=
CAL-85-1 NVHScJVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4L0UGlEPTB;OUKuOFghdk1? NW\ufXNPW0GQR1XS
ES6 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDaTWM2OD17Mj64N{BvVQ>? MXLTRW5ITVJ?
NCI-H650 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljNTWM2OD17ND6wPUBvVQ>? NIfFPYpUSU6JRWK=
NCI-H446 M1nqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG1Nm81UUN3ME25OU4yOiCwTR?= M2P5Z3NCVkeHUh?=
EW-13 NUD4NFhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT6TWM2OD17NT63OUBvVQ>? M{K3U3NCVkeHUh?=
HSC-2 NWG0Ulc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUW0emlpUUN3ME25OU45QSCwTR?= Ml7WV2FPT0WU
U031 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIq0XnNKSzVyPUm2Mlc{KG6P Mn\5V2FPT0WU
EW-11 NYXGbXBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;EfY1MUUN3ME25Ok45QCCwTR?= NXXqcmV[W0GQR1XS
GAK NG\BeFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTncoV7UUN3ME25PE46OyCwTR?= MYnTRW5ITVJ?
SK-OV-3 Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLKTWM2OD1zMECuNFchdk1? M1zrTHNCVkeHUh?=
OMC-1 NYi5[lJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1e5PGlEPTB;MUCwMlE5KG6P MnHQV2FPT0WU
TK10 NXfCW5JET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUf5SJZIUUN3ME2xNFAvOjFibl2= MYrTRW5ITVJ?
EKVX M4TQTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFyMD62JI5O Mn\hV2FPT0WU
Detroit562 NYS4RY9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFyMj6xO{BvVQ>? MUnTRW5ITVJ?
SF268 NX;jU5R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrzWGdTUUN3ME2xNFIvOzRibl2= MmTOV2FPT0WU
SNU-387 M3\J[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDYTWM2OD1zMESuNVchdk1? NVHR[W5IW0GQR1XS
MDA-MB-231 NXHjTJYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vUfGlEPTB;MUC1MlA3KG6P M3OzPXNCVkeHUh?=
NCI-H1563 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17MTmlEPTB;MUC1MlE5KG6P NY\LVIJoW0GQR1XS
D-502MG MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fyUmlEPTB;MUC1Mlchdk1? MkmwV2FPT0WU
A2780 NITO[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\RfmlEPTB;MUC2MlQ4KG6P NYP0VWFrW0GQR1XS
IA-LM MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLMTWM2OD1zMEeuOVEhdk1? NHqwTZdUSU6JRWK=
D-392MG M4Dv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2X3TWlEPTB;MUC3MlU1KG6P NGLWe|dUSU6JRWK=
MS-1 M3PKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTFTWM2OD1zMEeuO|Ehdk1? NFf0THlUSU6JRWK=
SW1990 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTETWM2OD1zMEiuOVQhdk1? M1jMcnNCVkeHUh?=
HEL M4G0cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrvVYtDUUN3ME2xNFkvOjlibl2= MYXTRW5ITVJ?
SW1573 MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;LN21OUUN3ME2xNFkvOzFibl2= NEPFbFZUSU6JRWK=
SW1783 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTFzMD6yNkBvVQ>? MmLsV2FPT0WU
COLO-680N NWK4XGU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFzMD63OkBvVQ>? MkTaV2FPT0WU
NCI-N87 Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LzZWlEPTB;MUGxMlA1KG6P NIPoR|RUSU6JRWK=
SK-MEL-28 NHXlZ4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\ndnV5UUN3ME2xNVEvPTVibl2= Mlj4V2FPT0WU
BT-20 NX\rO|ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFzMj6wNUBvVQ>? NE\qdphUSU6JRWK=
NCI-H1648 NYLvdYNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXwPVlXUUN3ME2xNVMhdk1? NYDJfnRYW0GQR1XS
no-11 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFzMz6yPEBvVQ>? Mm\IV2FPT0WU
MOLT-13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTSNJZXUUN3ME2xNVMvPDRibl2= NVzrTXBsW0GQR1XS
NCI-H2170 M{Tu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qxU2lEPTB;MUG0MlUyKG6P MWfTRW5ITVJ?
HTC-C3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTybXZyUUN3ME2xNVYvQDVibl2= Mmm0V2FPT0WU
LU-99A NYPxcow3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTFzNz6yNUBvVQ>? NYTER4t7W0GQR1XS
HCC2998 NFriR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml24TWM2OD1zMUeuPVIhdk1? MnPMV2FPT0WU
NB13 M3z0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX5UldWUUN3ME2xNVcvQTlibl2= MWnTRW5ITVJ?
GT3TKB MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjXTWM2OD1zMUiuNFghdk1? Mk[wV2FPT0WU
BT-549 NG\NN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzC[pN2UUN3ME2xNVgvQTVibl2= MmrvV2FPT0WU
NCI-H747 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlS0TWM2OD1zMUmuN|Qhdk1? MUXTRW5ITVJ?
EW-1 NG\PTpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF{MD6yJI5O MVfTRW5ITVJ?
LB831-BLC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[3TWM2OD1zMkCuOlMhdk1? M2HCfnNCVkeHUh?=
NMC-G1 NUHhNFVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXLRmtiUUN3ME2xNlEvOTFibl2= NH3PNHpUSU6JRWK=
COLO-679 M4rnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTF{Mj6xOUBvVQ>? NWHyfIZ1W0GQR1XS
HL-60 M{PYZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3mcnlKSzVyPUGyN{4yKG6P MUPTRW5ITVJ?
MKN7 NWDZcWI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTF{Mz64N{BvVQ>? NHnQNFRUSU6JRWK=
RERF-LC-MS NEP3dZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTF{ND6zNUBvVQ>? M4jhZ3NCVkeHUh?=
DMS-114 M2fafmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XtPGlEPTB;MUK1MlA6KG6P NFvoXmpUSU6JRWK=
HuP-T4 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HLdWlEPTB;MUK2Mlk4KG6P Mn35V2FPT0WU
HCC2157 M3HLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfKSnNKSzVyPUGyO{42KG6P M{PmWnNCVkeHUh?=
SKG-IIIa MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF{OD64JI5O NGnn[3JUSU6JRWK=
HCT-116 NYfqZXZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DPN2lEPTB;MUOwMlY1KG6P MW\TRW5ITVJ?
BB30-HNC NEXTTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7mZ3Q{UUN3ME2xN|AvPzhibl2= MULTRW5ITVJ?
KYSE-270 NFu2XoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF|MD64PEBvVQ>? Mly2V2FPT0WU
MFM-223 Ml3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTF|MT61NUBvVQ>? NW\GWG9MW0GQR1XS
NH-12 NHLO[|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[xTWM2OD1zM{KuPVkhdk1? M4fGe3NCVkeHUh?=
U-118-MG NGO4NHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjT[YRKSzVyPUGzN{43OiCwTR?= MlXHV2FPT0WU
ESS-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jJfGlEPTB;MUO1MlE5KG6P M4riO3NCVkeHUh?=
D-247MG Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjnd4FqUUN3ME2xN|UvOjFibl2= NHPKcJZUSU6JRWK=
IGROV-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljqTWM2OD1zM{WuO|Yhdk1? MY\TRW5ITVJ?
C-33-A MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfGcW9KSzVyPUGzOU46PyCwTR?= NGfBNYRUSU6JRWK=
NCI-H1693 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHaUYVKSzVyPUGzOk4yOiCwTR?= M{GzZ3NCVkeHUh?=
MLMA MnLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPKPIZKSzVyPUGzOk42QCCwTR?= Mk\nV2FPT0WU
SK-N-AS NFTvdZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLjTWM2OD1zM{euNVchdk1? M2jZeXNCVkeHUh?=
NCI-H1755 NEnCUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHO0fIdKSzVyPUGzPE45PSCwTR?= NVXWUGJtW0GQR1XS
CHP-134 NUDUbm5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2foVWlEPTB;MUO5MlU2KG6P MlTIV2FPT0WU
LS-513 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPJXnNDUUN3ME2xOFAvQTFicF2= Mk\RV2FPT0WU
TE-12 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ZU5BXUUN3ME2xOFAvQTNibl2= NXTDZZk2W0GQR1XS
KNS-42 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTHTWM2OD1zNESuN{BvVQ>? M1P4U3NCVkeHUh?=
SJRH30 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF2ND60OEBvVQ>? NVSyT|V2W0GQR1XS
NCI-H1092 NHrG[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnoV5pKSzVyPUG0OE42OiCwTR?= M1;ydXNCVkeHUh?=
H-EMC-SS NHLGcJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfGTWM2OD1zNE[uPFEhdk1? MVnTRW5ITVJ?
SK-MEL-3 NIHpXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSzNYtKSzVyPUG0O{42PSCwTR?= NYP4WmdVW0GQR1XS
SK-N-FI M4ewSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoexTWM2OD1zNEeuOVkhdk1? MlK1V2FPT0WU
NCI-H2126 NUnpfJlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF2OD6xOUBvVQ>? NIrNR29USU6JRWK=
NCI-H1299 Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fsWWlEPTB;MUWwMlIzKG6P NHzPR|ZUSU6JRWK=
CFPAC-1 NHnFcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW5eFUyUUN3ME2xOVAvPjZibl2= NUW2cXRGW0GQR1XS
NCI-H661 MnnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\lTWM2OD1zNUGuNlYhdk1? Mo\sV2FPT0WU
KYSE-70 MnjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;MTWM2OD1zNUGuO|khdk1? M3LwXHNCVkeHUh?=
SW900 NFHLdm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF3ND62OUBvVQ>? NYXVd3R[W0GQR1XS
Ca-Ski MoLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvsRWF4UUN3ME2xOVYvOzlibl2= NFW4VldUSU6JRWK=
HPAF-II NWC2[4FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTF3Nj60O{BvVQ>? MkjpV2FPT0WU
LB2518-MEL NInpTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37VdmlEPTB;MUW3MlEhdk1? MY\TRW5ITVJ?
LC-2-ad MoS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;ieHpKSzVyPUG1PE43OiCwTR?= M1i5PHNCVkeHUh?=
HCC1806 NWHFcnNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLFTWM2OD1zNkeuPFghdk1? MVfTRW5ITVJ?
UACC-62 MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPuZWV7UUN3ME2xOlgvODlibl2= NEPjVXRUSU6JRWK=
KM-H2 MnfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfkSnNMUUN3ME2xO|AvPThibl2= M1j6PXNCVkeHUh?=
NCI-H2347 NYTjV5lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLmN|BkUUN3ME2xO|IvPzJibl2= M4rMNXNCVkeHUh?=
SCC-15 NWXBVmNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\vTWM2OD1zN{OuOlYhdk1? MnLEV2FPT0WU
BB49-HNC M1;NVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF5Mz64NUBvVQ>? M4flVnNCVkeHUh?=
GMS-10 NYHVSWtrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF5Mz65OEBvVQ>? MU\TRW5ITVJ?
NCI-H2052 M4DpVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT1U3ZKSzVyPUG3OE46KG6P MXfTRW5ITVJ?
SW626 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml32TWM2OD1zN{[uNFYhdk1? MWHTRW5ITVJ?
MDA-MB-415 NWjlVopGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTF5Nj62NUBvVQ>? MlH5V2FPT0WU
Saos-2 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDaVGJXUUN3ME2xO|kvOzVibl2= NXnqXYNXW0GQR1XS
DK-MG NH7tSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH6b5A3UUN3ME2xPFAvOyCwTR?= MVPTRW5ITVJ?
SNU-C2B NGi2NVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r3W2lEPTB;MUiwMlc{KG6P M{\FUHNCVkeHUh?=
A427 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3QTWM2OD1zOEKuOVchdk1? NIDPcmdUSU6JRWK=
KP-N-YS NFqw[3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrSO3NmUUN3ME2xPFUhdk1? M3zBdnNCVkeHUh?=
J82 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHK4ZWlKSzVyPUG4OU4yQCCwTR?= NXrQWYdwW0GQR1XS
LS-411N NGfCeo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PlTWlEPTB;MUi3MlI5KG6P MWXTRW5ITVJ?
HCC1937 NF73TodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLuSppkUUN3ME2xPFcvPDlibl2= M3LOW3NCVkeHUh?=
OE33 NXjZcVR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTF6OD65O{BvVQ>? MVLTRW5ITVJ?
NB7 NF7IPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfJUZpKSzVyPUG4PU45QSCwTR?= M1SzXnNCVkeHUh?=
SW684 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPibndKSzVyPUG5Ok4yOyCwTR?= M2HNbXNCVkeHUh?=
HT-144 M4LUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTF7Nj6xOUBvVQ>? NHnkWGJUSU6JRWK=
SK-MEL-30 M4LtVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvnTWM2OD1zOU[uNkBvVQ>? M3;ZUnNCVkeHUh?=
DBTRG-05MG NXPBVZRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF7OD60O{BvVQ>? MnXJV2FPT0WU
NCI-H1395 NULWfZJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIm5dYRKSzVyPUG5PE45PSCwTR?= M{\RRXNCVkeHUh?=
NCI-H2122 M3fZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rDeWlEPTB;MkCwMlU6KG6P M1HuOHNCVkeHUh?=
no-10 NF3zbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7UTWM2OD1{MEGuNFQhdk1? MWPTRW5ITVJ?
SW48 M{HjO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTJyMT6zNUBvVQ>? M3zwUXNCVkeHUh?=
NCI-H1650 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJyND6wNUBvVQ>? MYTTRW5ITVJ?
MZ1-PC Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{KyVmlEPTB;MkC1MlU5KG6P NHG2T3lUSU6JRWK=
U-266 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXDTWM2OD1{MEWuO|khdk1? MnfqV2FPT0WU
CAS-1 NXiwe5M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyzTWM2OD1{MEeuOFQhdk1? NF;IOFlUSU6JRWK=
AU565 M4\obGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj6cIpTUUN3ME2yNVIvQDJibl2= M{mxTXNCVkeHUh?=
UACC-257 M4fFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfET|RKSzVyPUKxN{46QSCwTR?= NWHaWFZmW0GQR1XS
CAL-27 NGLRPI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT6TWM2OD1{MUeuNFUhdk1? MXXTRW5ITVJ?
NCI-H23 NHq4SIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LWV2lEPTB;MkG5MlM{KG6P NGfPfoRUSU6JRWK=
TE-6 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTJzOT62PEBvVQ>? MYPTRW5ITVJ?
TGBC24TKB NWnGTJdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvUTWM2OD1{MkKuNVchdk1? M{PKfHNCVkeHUh?=
TE-1 M2[5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TDVWlEPTB;MkKyMlg5KG6P M1jSRnNCVkeHUh?=
RCC10RGB M2fqe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnHeJBmUUN3ME2yNlQvOTlibl2= MmW3V2FPT0WU
NCI-H596 NFTVO5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ{OD6yNkBvVQ>? NXnQV3VDW0GQR1XS
SW954 NWDSfHRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[4TWM2OD1{M{OuPFMhdk1? NVy1cHoxW0GQR1XS
NCI-H2087 NIjFbGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK4NZFKSzVyPUKzOE42OSCwTR?= NVf3PFdCW0GQR1XS
SK-PN-DW MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ|NT6xPUBvVQ>? MVjTRW5ITVJ?
KM12 NHnWTo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vZUmlEPTB;MkO1Mlchdk1? NF2xPHNUSU6JRWK=
BT-474 NFP5cpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7ZTWM2OD1{M{WuO|Mhdk1? MXTTRW5ITVJ?
IST-MES1 NYX6NYQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln6TWM2OD1{M{[uOVchdk1? NG\lUZBUSU6JRWK=
HT-1197 M{fi[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf6PZVKSzVyPUKzPE4xQSCwTR?= NFLXSIFUSU6JRWK=
CAL-54 NUSyS4ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvYNIdKSzVyPUKzPE41QSCwTR?= NV;JblRHW0GQR1XS
NB10 M3fkWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTyTWM2OD1{NECuNFYhdk1? MVXTRW5ITVJ?
PANC-10-05 M{Pqdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknvTWM2OD1{NEWuOVYhdk1? M4izbXNCVkeHUh?=
NCI-H522 NUP3S|UxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHudYdKSzVyPUK0PE4{OSCwTR?= M2LETXNCVkeHUh?=
A388 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnFVopKSzVyPUK0PU45OiCwTR?= MkXJV2FPT0WU
GOTO MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJ3MD6yPUBvVQ>? NUnIO5ZiW0GQR1XS
KLE Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zZZWlEPTB;MkWxMlg4KG6P MojnV2FPT0WU
KYSE-520 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fsU2lEPTB;MkWyMlg3KG6P MVjTRW5ITVJ?
HCE-4 Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLV[o8{UUN3ME2yOlIvPSCwTR?= NX\xPHNQW0GQR1XS
KURAMOCHI NX7UW|g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJ4NT65JI5O MYHTRW5ITVJ?
HCC38 NUmyWZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTJ4Nj60PEBvVQ>? MX\TRW5ITVJ?
FADU M{\ZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTJ4Nj62N{BvVQ>? Mo\hV2FPT0WU
CW-2 MmjUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPQN5ZYUUN3ME2yOlkvQTZibl2= NVz1eIlYW0GQR1XS
L-428 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jwfWlEPTB;Mke1MlE2KG6P M1rUUXNCVkeHUh?=
HCC1569 Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ5NT64OEBvVQ>? MYLTRW5ITVJ?
NCI-H810 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PMcWlEPTB;Mke4MlMyKG6P M1j1cnNCVkeHUh?=
LB771-HNC NHOxUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrPUXN1UUN3ME2yPFUvQDRibl2= MVrTRW5ITVJ?
LCLC-103H Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUmwU2NTUUN3ME2yPFUvQTlibl2= M{W1RXNCVkeHUh?=
EFO-21 M{K3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTJ6Nz62PEBvVQ>? NWPBVIx[W0GQR1XS
CAL-72 NEi4N|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTzO|NKSzVyPUK5N{4yQSCwTR?= NYHyRXh7W0GQR1XS
SCC-9 NHfFd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTJ7Mz6yNkBvVQ>? MlroV2FPT0WU
COLO-829 NYLNfHQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHufJluUUN3ME2yPVYvPSCwTR?= MX;TRW5ITVJ?
U-87-MG MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTNyMD63N{BvVQ>? NXjZT3NRW0GQR1XS
MZ7-mel MmLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL0TmVKSzVyPUOyN{44PiCwTR?= NY[0VXR2W0GQR1XS
NCI-H1770 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTZTWM2OD1|Mk[uO|Qhdk1? NVnhUIM2W0GQR1XS
ChaGo-K-1 M2P6Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTN{OD6xJI5O NHHUPI5USU6JRWK=
SiHa NH;pOGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTN{OT6yOEBvVQ>? NYfhO446W0GQR1XS
NCI-SNU-5 NVOzS|NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLnZYV7UUN3ME2zN|YvPzdibl2= NE[0NWZUSU6JRWK=
DJM-1 M1q2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfyfWg1UUN3ME2zOFAvOzNibl2= MmPqV2FPT0WU
OE19 MkiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvmTWM2OD1|NECuOVMhdk1? MoDOV2FPT0WU
NCI-H1651 NUHNenlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYS3XGVVUUN3ME2zOFQvOThibl2= NFf5TpVUSU6JRWK=
COLO-792 NVfZUVZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XPNWlEPTB;M{W0MlQzKG6P M4C3cHNCVkeHUh?=
ACHN MlLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7WTWM2OD1|NU[uO|Ehdk1? MXvTRW5ITVJ?
TH-3 M2LwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN5OT65OUBvVQ>? NE\BVI9USU6JRWK=
HT-1376 M4fYTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\rcWlEPTB;M{i0Mlg5KG6P MmX3V2FPT0WU
RH-18 NEnLTZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nPcmlEPTB;M{m0Mlc1KG6P NXzOfIJJW0GQR1XS
NB6 NX\mO|JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvnU3lKSzVyPUO5Ok43PiCwTR?= MYTTRW5ITVJ?
COLO-320-HSR MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzOe5I4UUN3ME20NFMvOzdibl2= M1XMdHNCVkeHUh?=
UACC-893 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXqxdIxkUUN3ME20NFYvPDdibl2= M3TjdnNCVkeHUh?=
DSH1 NHzZ[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTRyNj65NUBvVQ>? NEf1S|RUSU6JRWK=
TE-10 MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD1O2o5UUN3ME20NFcvODFibl2= NH;XVoVUSU6JRWK=
HCC70 NXHBeoxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTRyOT6yNUBvVQ>? MmLCV2FPT0WU
TGBC11TKB MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDWTWM2OD12MUCuN|Mhdk1? MWTTRW5ITVJ?
NCI-H727 NFzIb41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle2TWM2OD12MUKuNVEhdk1? MkfjV2FPT0WU
ALL-PO M3v3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnUenVPUUN3ME20NVUvPjlibl2= NGSxOYZUSU6JRWK=
ABC-1 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofzTWM2OD12MkCuOFUhdk1? MnnjV2FPT0WU
NCI-H69 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOzUpNHUUN3ME20NlYvPzZibl2= M3;OOXNCVkeHUh?=
GP5d MlHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTYeHBKSzVyPUSzOE41OSCwTR?= M{j0PHNCVkeHUh?=
UMC-11 M{HyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYn3bVRFUUN3ME20OVgvOzZibl2= NFm0XnZUSU6JRWK=
RMG-I M3PaT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjBWoNKSzVyPUS2O{42PiCwTR?= M4KxNXNCVkeHUh?=
YAPC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLXRWdKSzVyPUS5NE43KG6P M4LFcHNCVkeHUh?=
LS-1034 MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y3VWlEPTB;NEmxMlA3KG6P M4TYTHNCVkeHUh?=
RCM-1 NGHCTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\2SIpKSzVyPUS5Ok43QCCwTR?= NWnQU3pxW0GQR1XS
HCC1954 NGjHc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\uZ2dKSzVyPUWxNk42KG6P Mlz3V2FPT0WU
SK-MEL-24 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TWemlEPTB;NUG2MlUyKG6P M4nIcXNCVkeHUh?=
NB12 NWLuSmN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTV{OD60NkBvVQ>? MkXzV2FPT0WU
SW756 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTV3ND65OkBvVQ>? M2H3R3NCVkeHUh?=
HCC1187 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\GTXBYUUN3ME21O|UvQDNibl2= MVPTRW5ITVJ?
NCI-H2342 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13sUGlEPTB;NUmwMlM6KG6P MlTIV2FPT0WU
NCI-H2291 MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTV7OD6zNUBvVQ>? MXfTRW5ITVJ?
OVCAR-3 Mo\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXxNZVKSzVyPUW5PE46PiCwTR?= M4Hnc3NCVkeHUh?=
MHH-NB-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[1TWM2OD14MkmuNFEhdk1? MVnTRW5ITVJ?
SAS NUD0UVRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnPTWM2OD14NUKuOlchdk1? M4rzbXNCVkeHUh?=
COLO-824 NUPTT29oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nkfWlEPTB;Nki5MlM4KG6P NVHZ[Yh7W0GQR1XS
HCC1395 NXjEeWN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\kTGRSUUN3ME22PVgvPSCwTR?= MnXxV2FPT0WU
COLO-668 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnx[GxKSzVyPUewOk4yKG6P Ml65V2FPT0WU
NCI-H226 NGPTfIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmWxTWM2OD15MEeuPEBvVQ>? NG\DXG1USU6JRWK=
NB17 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[wTWM2OD15MkGuO|Uhdk1? MlPmV2FPT0WU
SW1463 MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnSZ|BKSzVyPUezPU4yQSCwTR?= MmLHV2FPT0WU
TGW NFXuUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD5TWM2OD15NkCuNVUhdk1? MV\TRW5ITVJ?
NCI-H526 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTh{Mz61N{BvVQ>? NXr6V206W0GQR1XS
COR-L88 M1XQVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zvb2lEPTB;OES4MlEzKG6P NUGySHlzW0GQR1XS
NCI-H441 M{TnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyxTWM2OD16OUWuNlIhdk1? MnjOV2FPT0WU
NCI-H630 M2nkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV30dodvUUN3ME25NVIvQTZibl2= MlPuV2FPT0WU
Mo-T NHzQXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO1fld7UUN3ME25OFcvQDhibl2= MWDTRW5ITVJ?
JAR MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGi0fYtKSzVyPUm1Ok4zPCCwTR?= NGDMeolUSU6JRWK=
NCI-H1838 NFHadY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TLWmlEPTB;MT6wNlM5QCEQvF2= M3vBS3NCVkeHUh?=
DoTc2-4510 M2njeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TkR2lEPTB;MT6wO|M4PiEQvF2= MYLTRW5ITVJ?
MKN28 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTFwMEmwNlQh|ryP NHPSUYpUSU6JRWK=
HuP-T3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme5TWM2OD1zLkGxPVA2KM7:TR?= Mlu4V2FPT0WU
TE-9 NV;v[FdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\WUIFPUUN3ME2xMlEzQTd|IN88US=> M1fwXHNCVkeHUh?=
NY MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljBTWM2OD1zLkG2O|kzKM7:TR?= NFrnWXRUSU6JRWK=
HT55 NHfMcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF60ZmZKSzVyPUGuN|E{PDRizszN NX;jfoR1W0GQR1XS
SW837 M2jaVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzOPXp3UUN3ME2xMlMzQTd6IN88US=> MYfTRW5ITVJ?
NCI-H2029 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzGNm9FUUN3ME2xMlQyPzlzIN88US=> NYrKXmFPW0GQR1XS
IST-SL1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzNTWM2OD1zLkS0NlQh|ryP NH7DWm1USU6JRWK=
COLO-741 NX\tUFdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\TbFRLUUN3ME2xMlQ6PzdzIN88US=> M3PpRnNCVkeHUh?=
LU-65 NGjqWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\GXGdFUUN3ME2xMlYzOjR7IN88US=> MX\TRW5ITVJ?
NCI-H1304 NYjwUYNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7rPI9nUUN3ME2xMlY2PDl6IN88US=> M3\0THNCVkeHUh?=
KARPAS-299 MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn1V49KSzVyPUGuO|k1PzlizszN NFPIfZlUSU6JRWK=
NCI-H358 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrMbXpKSzVyPUGuPVU2ODNizszN NEmxbmhUSU6JRWK=
OAW-28 NFrnRo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljBTWM2OD1{LkC2PVE6KM7:TR?= NYDOS4VFW0GQR1XS
C8166 NWnUOm8{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ThS2lEPTB;Mj62N|M6OiEQvF2= NHTrbmFUSU6JRWK=
COLO-678 M2flNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\je4FmUUN3ME2yMlg{PzZ6IN88US=> MYfTRW5ITVJ?
SK-N-DZ NITHenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwOE[zPFEh|ryP MoPYV2FPT0WU
NCI-H82 NVPDeFBMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{n1VGlEPTB;Mj65NFM3QSEQvF2= M3TLTHNCVkeHUh?=
JVM-2 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnyTpFwUUN3ME2zMlA{OTh6IN88US=> NUjKN3RGW0GQR1XS
SW1116 M1;aPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvGTWM2OD1|LkC1OFEyKM7:TR?= MYHTRW5ITVJ?
MDA-MB-453 NFLFe|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPFTWM2OD1|LkGwOFM6KM7:TR?= MXzTRW5ITVJ?
Calu-6 NVLHe3JzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vpOGlEPTB;Mz6xPVk4KM7:TR?= MWfTRW5ITVJ?
SHP-77 M2XW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LyZmlEPTB;Mz61Nlgh|ryP M2L2XXNCVkeHUh?=
Capan-2 NU\TTGhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH63NnVKSzVyPUSuN|I2QDFizszN M2n5dXNCVkeHUh?=
SW948 M2TKPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwN{S3O|kh|ryP NFjTR3JUSU6JRWK=
HDLM-2 NFfFfW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofOTWM2OD13LkC3O|I2KM7:TR?= M4DwdXNCVkeHUh?=
LAN-6 NX3FVpE1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLDOppEUUN3ME22MlIyPDl3IN88US=> MnXOV2FPT0WU
LU-135 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjpUmdlUUN3ME22MlQ{ODd5IN88US=> MX3TRW5ITVJ?
T84 NEfX[FZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHxXGlKSzVyPU[uPVg3PCEQvF2= M1rNbnNCVkeHUh?=
CAPAN-1 NEPKR3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTdwNkKyN|Mh|ryP M{fxSXNCVkeHUh?=
SW1417 MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XGcmlEPTB;Nz65NVc{OSEQvF2= MXfTRW5ITVJ?
BALL-1 M3nUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHniRWJKSzVyPUiuOVA1ODlizszN M1zNcnNCVkeHUh?=
HT-29 NXj6XJJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDnZ3BKSzVyPUmuNFc2QTlizszN NGO2[IdUSU6JRWK=
C3A NILoZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDKTWM2OD17Lki4N|k1KM7:TR?= MnHKV2FPT0WU
NCI-H1993 NYrpcmVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DSW2lEPTB;MUCuOVA5OSEQvF2= NWnaNGZkW0GQR1XS
SK-MEL-1 M3j0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLjUG9KSzVyPUGxMlYzQDlizszN M{\hVnNCVkeHUh?=
DU-145 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXSZZJoUUN3ME2xOE42ODV{IN88US=> MmDUV2FPT0WU
KP-N-YN NF\1[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\ieGlEPTB;MUSuOVExOyEQvF2= MlmzV2FPT0WU
CCRF-CEM Ml35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3yzV2lEPTB;MUSuO|gxQSEQvF2= NYj4UJB5W0GQR1XS
ZR-75-30 NU\OT5dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;Dd3dZUUN3ME2xOk4{OzB|IN88US=> MXvTRW5ITVJ?
A673 NGj5eFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ju[GlEPTB;MkCuOVUxPyEQvF2= MmrkV2FPT0WU
K-562 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HYbmlEPTB;MkiuOFE5OyEQvF2= MmfDV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

- Collapse

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

- Collapse
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

- Collapse
  • Animal Models: Female Harlan athymic nude mice
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+PEG300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms NVP-BEZ235
Smiles CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01856101 Terminated Drug: BEZ235 Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Drug: BEZ235|Drug: Prednisone|Drug: Abiraterone acetate Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01756118 Unknown status Drug: BEZ235 Acute Lymphoblastic Leukemia|Leukemia Myelocytic Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells Johann Wolfgang Goethe University Hospital June 2012 Phase 1
NCT01290406 Withdrawn Drug: BEZ235 Endometrial Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01288092 Withdrawn Drug: BEZ235 Metastatic Breast Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy Dactolisib (BEZ235) | Dactolisib (BEZ235) supplier | purchase Dactolisib (BEZ235) | Dactolisib (BEZ235) cost | Dactolisib (BEZ235) manufacturer | order Dactolisib (BEZ235) | Dactolisib (BEZ235) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID