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Dactolisib (BEZ235)

For research use only.

Catalog No.S1009 Synonyms: NVP-BEZ235

375 publications

Dactolisib (BEZ235) Chemical Structure

CAS No. 915019-65-7

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.

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Selleck's Dactolisib (BEZ235) has been cited by 375 publications

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Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. Dactolisib induces autophagy and suppresses HIV-1 replication. Phase 2.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MnfERY51cW2rY4LvZolidCCDc4PhfS=> MYCxPEBp NUL2elNITE2VTx?= NY\kc2dFSW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= MViyOFgxPTl2Nh?=
MCF7 NVfxTG95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[wMlAyNTFyMDFOwG0> MVW0PEBp M1;SeGROW09? NH;zUoNKSzVyPUCuO|Mh|ryP NWC5U4I5OjN6N{G5NFQ>
HCT116 NFfmWHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvJTJcyOC5yMT2xNFAh|ryP MUS0PEBp NVq5NWNLTE2VTx?= MmfXTWM2OD1zLkG2JO69VQ>? NF3mc|gzOzh5MUmwOC=>
U87MG Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPENE4xOS1zMECg{txO M1rCfFQ5KGh? NF\rTZZFVVOR Ml23TWM2OD1zLkOyJO69VQ>? NXTXdJBEOjN6N{G5NFQ>
HBC4 Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDPSJgxNjBzLUGwNEDPxE1? NHXKRWk1QCCq MUXMc4chT0l3ME2tPE43OSCP MnjNNlI{OzZ{NE[=
BSY1 M3rrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS5NE4xOS1zMECg{txO NILXbWc1QCCq NH;TeVlNd2diR1m1NF0uQC52ODDN M1vxR|IzOzN4MkS2
HBC5 NY\LPYNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\XSlAvODFvMUCwJO69VQ>? NH;xXVI1QCCq NGrmPJlNd2diR1m1NF0uPy56NzDN MXeyNlM{PjJ2Nh?=
MCF7 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOwMlAyNTFyMDFOwG0> NVvoWGtLPDhiaB?= NHTVbItNd2diR1m1NF0uQC5zNjDN MYWyNlM{PjJ2Nh?=
MDA-MB-231 NWTKUpp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvZNlk6OC5yMT2xNFAh|ryP MkiwOFghcA>? M2HkfGxw\yCJSUWwQU05NjB7IF2= MkHjNlI{OzZ{NE[=
U251 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjuc|ZTOC5yMT2xNFAh|ryP MoHKOFghcA>? Mn;hUI9oKEeLNUC9MVcvPjZiTR?= MnrHNlI{OzZ{NE[=
SF268 NX\2elVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW1NE4xOS1zMECg{txO MYG0PEBp MlTiUI9oKEeLNUC9MVcvQTJiTR?= MnTjNlI{OzZ{NE[=
SF295 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWKwMlAyNTFyMDFOwG0> MVm0PEBp NEjpPG1Nd2diR1m1NF0uQC5|MTDN Ml;HNlI{OzZ{NE[=
SF539 NV3BTIw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O0T|AvODFvMUCwJO69VQ>? NHrUe4w1QCCq M2Wwemxw\yCJSUWwQU05NjV7IF2= Mkj2NlI{OzZ{NE[=
SNB75 NY\LZpBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LsPFAvODFvMUCwJO69VQ>? MX:0PEBp MlL3UI9oKEeLNUC9MVgvPThiTR?= M4G2d|IzOzN4MkS2
SNB78 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLLNE4xOS1zMECg{txO NXXkOWdjPDhiaB?= M4TPeGxw\yCJSUWwQU05NjZ3IF2= MlTWNlI{OzZ{NE[=
HCC2998 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjFN3cxNjBzLUGwNEDPxE1? NYLtVohuPDhiaB?= Mmf6UI9oKEeLNUC9MVgvODViTR?= M4XacFIzOzN4MkS2
KM12 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYOwMlAyNTFyMDFOwG0> NEPpOlg1QCCq M1\3bWxw\yCJSUWwQU04NjV2IF2= MlfaNlI{OzZ{NE[=
HT-29 NGrxeItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L4WVAvODFvMUCwJO69VQ>? MmG3OFghcA>? M3u1WGxw\yCJSUWwQU04Njd3IF2= MoHUNlI{OzZ{NE[=
HCT15 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH5fVkxNjBzLUGwNEDPxE1? NFfsWGw1QCCq NWrJXGN2VG:pIFfJOVA:NThwMEOgUS=> NIO5[ZMzOjN|NkK0Oi=>
HCT116 NXfiW2FtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLSNE4xOS1zMECg{txO MorjOFghcA>? NGjmWI9Nd2diR1m1NF0uPy54MTDN MmLJNlI{OzZ{NE[=
NCI-H23 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33TPFAvODFvMUCwJO69VQ>? M{LiZ|Q5KGh? NFj4TXFNd2diR1m1NF0uPy54NDDN MnPNNlI{OzZ{NE[=
NCI-H226 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEftR|cxNjBzLUGwNEDPxE1? MlzkOFghcA>? NXj2VoE5VG:pIFfJOVA:NThwNESgUS=> MVWyNlM{PjJ2Nh?=
NCI-H522 Mn3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPSNldoOC5yMT2xNFAh|ryP Ml\qOFghcA>? M{HK[Wxw\yCJSUWwQU05NjR3IF2= MmnZNlI{OzZ{NE[=
NCI-H438 M1vBbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDtZocxNjBzLUGwNEDPxE1? NVr5dlBRPDhiaB?= NGfIRpVNd2diR1m1NF0uQC5zMTDN Mn6wNlI{OzZ{NE[=
A549 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DLWlAvODFvMUCwJO69VQ>? Ml\QOFghcA>? MV7Mc4chT0l3ME2tPE4xPyCP M2DQWlIzOzN4MkS2
DMS273 NWO5OHRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKwMlAyNTFyMDFOwG0> MmnPOFghcA>? MkHQUI9oKEeLNUC9MVcvQDBiTR?= NUX3W3hPOjJ|M{[yOFY>
DMS114 NGnB[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVmwMlAyNTFyMDFOwG0> NGXodZU1QCCq MX7Mc4chT0l3ME2tPE4{QSCP MYeyNlM{PjJ2Nh?=
LOXIMVI MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWKwMlAyNTFyMDFOwG0> NH;6VmY1QCCq MoXtUI9oKEeLNUC9MVgvPjZiTR?= MYiyNlM{PjJ2Nh?=
OVCAR3 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWiwMlAyNTFyMDFOwG0> M{D0fVQ5KGh? MUjMc4chT0l3ME2tPE4yPyCP MXuyNlM{PjJ2Nh?=
OVCAR4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrGNE4xOS1zMECg{txO NYHmZmhkPDhiaB?= NIni[29Nd2diR1m1NF0uQC53ODDN NGjBUlYzOjN|NkK0Oi=>
OVCAR5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f2dlAvODFvMUCwJO69VQ>? MmTjOFghcA>? NGLlSJhNd2diR1m1NF0uPy53NzDN MoXVNlI{OzZ{NE[=
OVCAR8 NGTrXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPuTVlGOC5yMT2xNFAh|ryP MUK0PEBp NUTmNZFjVG:pIFfJOVA:NTdwOESgUS=> NFTMVJgzOjN|NkK0Oi=>
SKOV3 MoPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHoepNNOC5yMT2xNFAh|ryP M{\ubVQ5KGh? MWrMc4chT0l3ME2tPE41OSCP M{m2NVIzOzN4MkS2
RXF631L NEXKUlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;LO3QxNjBzLUGwNEDPxE1? NFP4N2g1QCCq MWHMc4chT0l3ME2tPE4zOSCP NFTu[3gzOjN|NkK0Oi=>
ACHN M2L1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPFXG5EOC5yMT2xNFAh|ryP NG\FVmI1QCCq M1\Oe2xw\yCJSUWwQU04Njl3IF2= Mk\DNlI{OzZ{NE[=
St-4 NUfpNIRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYiwMlAyNTFyMDFOwG0> NV76dmJvPDhiaB?= NGm4UVNNd2diR1m1NF0uPy52NzDN NVLVOnNzOjJ|M{[yOFY>
MKN1 NHK1XZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHqNE4xOS1zMECg{txO NH7UXGY1QCCq M4LtZmxw\yCJSUWwQU05NjRzIF2= M4rTO|IzOzN4MkS2
MKN7 NH3CO3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYqwMlAyNTFyMDFOwG0> MYS0PEBp NIXqN|NNd2diR1m1NF0uPy54ODDN NHHUZnAzOjN|NkK0Oi=>
MKN28 NVjFXHY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvmcFNNOC5yMT2xNFAh|ryP NUHh[HFUPDhiaB?= NV3zT4x[VG:pIFfJOVA:NTdwMEegUS=> NWjYeVhOOjJ|M{[yOFY>
MKN45 Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K2SVAvODFvMUCwJO69VQ>? MVm0PEBp MUDMc4chT0l3ME2tPE4{PCCP NEH2UVkzOjN|NkK0Oi=>
MKN74 NGPXdGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofoNE4xOS1zMECg{txO NXmyenloPDhiaB?= NIrqd3BNd2diR1m1NF0uPy52MjDN NWHxTIJ4OjJ|M{[yOFY>
DU145 Ml3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUOwMlAyNTFyMDFOwG0> MUS0PEBp NV;UepFVVG:pIFfJOVA:NThwMU[gUS=> M3XnS|IzOzN4MkS2
PC3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV6wMlAyNTFyMDFOwG0> MWi0PEBp NFrwXZlNd2diR1m1NF0uQC54NjDN MX6yNlM{PjJ2Nh?=
Trypanosoma brucei brucei MVfGeY5kfGmxbjDBd5NigQ>? NFe0Om4zODBibl2= NHXJT2wyOiCq MkHmSG1UVw>? MkCxSIVkemWjc3WgbY4heGixc4Doc5Rq\HmuIHnuc5NqfG:uIIDoc5NxcGG2ZTDs[ZZmdA>? NVKwc|QxOjR6MEW5OFY>
Trypanosoma brucei brucei Mk\lSpVv[3Srb36gRZN{[Xl? MXixPEBp NXjCUFdDTE2VTx?= NVvJ[WFYUW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= M2P0fFI1QDB3OUS2
Trypanosoma brucei brucei M1z5b2Z2dmO2aX;uJGF{e2G7 NYLjeW5KOjByIH7N MlHINVIhcA>? NYTDOmZkTE2VTx?= MljPSYZn\WO2IH;uJJNxcGmwZ3;tfYxmcW5ibHX2[Yw> NIf0bFQzPDhyNUm0Oi=>
Trypanosoma brucei brucei M1;wOmZ2dmO2aX;uJGF{e2G7 NYfuWmRjOjByIH7N MYmxNkBp M4T3c2ROW09? MoDSSYZn\WO2IH;uJJBpd3OyaHH0bYR6dGOqb3zpcoUhdGW4ZXy= MXiyOFgxPTl2Nh?=
UM-UC-3 NI[2R2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:y[ZlKSzVyPUOxOUBxVQ>? MY\TRW5ITVJ?
SBC-1 Ml\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTd2MjDwUS=> NWrtRYo2W0GQR1XS
MKN1 NG\TOHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULVcJJMUUN3ME2yMlghdk1? NHXXSplUSU6JRWK=
NCI-H720 M3TNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXH6TJJxUUN3ME2zMlU4KG6P NXnYWYFPW0GQR1XS
BFTC-909 NH3Ve|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX5OVRtUUN3ME2zMlcyKG6P M{\4V3NCVkeHUh?=
BPH-1 NITuXIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\2fmd2UUN3ME20Mlc3KG6P M1i3WXNCVkeHUh?=
PC-3 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{n6U2lEPTB;NT6wPUBvVQ>? M1HwOHNCVkeHUh?=
AN3-CA M3jFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjLXYlKSzVyPUWuOVYhdk1? MVfTRW5ITVJ?
HN NFPHS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPscolKSzVyPUWuPVYhdk1? M2CzeHNCVkeHUh?=
HCC2218 M1:0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjUTWM2OD14Lk[xJI5O NXPKNW5ZW0GQR1XS
KP-4 NYjudWFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnNO3RTUUN3ME23JI5O MnLpV2FPT0WU
LU-139 M4fUUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnqWXlGUUN3ME23Mlc4KG6P M4PM[HNCVkeHUh?=
ETK-1 MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTBdoFKSzVyPUeuPFghdk1? MX\TRW5ITVJ?
Ramos-2G6-4C10 M1\uV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXThVpFHUUN3ME24MlQ6KG6P MUfTRW5ITVJ?
MHH-PREB-1 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD2Ulc1UUN3ME25MlEzKG6P Mkj6V2FPT0WU
DU-4475 NXTadmV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7PTWM2OD17LkS0JI5O M2jjVnNCVkeHUh?=
NCI-H1666 NYfwfVlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfyN5NKUUN3ME25MlcyKG6P M3HOTXNCVkeHUh?=
CAMA-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTlwODDuUS=> M1jKcXNCVkeHUh?=
TYK-nu MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTlwOUSgcm0> NGf1d2FUSU6JRWK=
MFE-280 NX7pNGZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nVemlEPTB;OT65PUBvVQ>? NGXOV4VUSU6JRWK=
A549 M3TJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPQTppiUUN3ME2xNE4yPCCwTR?= MoHjV2FPT0WU
769-P NGXiPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTYSmJKSzVyPUGwMlQ1KG6P NWrjNnhDW0GQR1XS
L-363 M3;1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PNRWlEPTB;MUCuOlkhdk1? MVrTRW5ITVJ?
ES8 MonkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW1clJKSzVyPUGwMlkhdk1? MmDpV2FPT0WU
PA-1 M4W2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFzLkiyJI5O NGrremhUSU6JRWK=
Mewo M3jMNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFzLkm5JI5O NYfxe2V5W0GQR1XS
HSC-3 NVr0PVN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPoTWM2OD1zMj6yNUBvVQ>? NIjOcXdUSU6JRWK=
H4 NEPvS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULZVYZLUUN3ME2xNk43PyCwTR?= NVfkT4NUW0GQR1XS
BB65-RCC NYjPV4UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF{LkeyJI5O MUnTRW5ITVJ?
NCI-H1793 NVO3ZnVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DNVWlEPTB;MUKuPFIhdk1? Mly4V2FPT0WU
KARPAS-45 NWLr[FdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLpTWM2OD1zMz61NUBvVQ>? M1fHOXNCVkeHUh?=
GCT NEXHPFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEThUWxKSzVyPUGzMlY5KG6P MYnTRW5ITVJ?
EoL-1 NFTC[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LVUmlEPTB;MUOuPVMhdk1? NXntfo9UW0GQR1XS
LB2241-RCC MmHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTF2LkCxJI5O Mn7LV2FPT0WU
ES5 NH;WO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;kW2lEPTB;MUSuO|Qhdk1? M3fVcnNCVkeHUh?=
LOXIMVI NWPQS2RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVyzWlZbUUN3ME2xOE46QSCwTR?= MXrTRW5ITVJ?
COR-L105 M3vvTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGmzXYFKSzVyPUG1MlA1KG6P NWD0UYFCW0GQR1XS
P12-ICHIKAWA NUHydFdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWn0UGZQUUN3ME2xOU4yKG6P MWnTRW5ITVJ?
CHL-1 NUTyeIFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnO3TWM2OD1zNT60OUBvVQ>? M{fEUnNCVkeHUh?=
VMRC-RCZ NYjRWYt6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTrbplKSzVyPUG1MlY{KG6P NHvhNFBUSU6JRWK=
HH M3fWNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz6V21{UUN3ME2xOU44KG6P M3voenNCVkeHUh?=
NUGC-3 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF4LkO0JI5O M1joSnNCVkeHUh?=
EGI-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTlTWM2OD1zNj60N{BvVQ>? MXnTRW5ITVJ?
OS-RC-2 NX;Y[5ljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLpTWM2OD1zNj60O{BvVQ>? MWjTRW5ITVJ?
MOLT-16 MkD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi2[lVbUUN3ME2xO{4yPSCwTR?= MljjV2FPT0WU
NCI-H209 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF5LkK5JI5O M4ixcnNCVkeHUh?=
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NCI-H2087 M1u4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fL[2lEPTB;MkO0MlUyKG6P NFGyZ|RUSU6JRWK=
SK-PN-DW NXLDe2dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIH4[GxKSzVyPUKzOU4yQSCwTR?= NUDXS446W0GQR1XS
KM12 NFP2fJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXGTWM2OD1{M{WuO{BvVQ>? MlHzV2FPT0WU
BT-474 NFv4VVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ|NT63N{BvVQ>? M{jKWHNCVkeHUh?=
IST-MES1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHIO2lKSzVyPUKzOk42PyCwTR?= NF3qSFFUSU6JRWK=
HT-1197 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfRU25KSzVyPUKzPE4xQSCwTR?= MkLPV2FPT0WU
CAL-54 NWTQbGdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDtcotKSzVyPUKzPE41QSCwTR?= NVXld21lW0GQR1XS
NB10 NXm0VmN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzsc|JKSzVyPUK0NE4xPiCwTR?= M2HTU3NCVkeHUh?=
PANC-10-05 NFv1cnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\PNWlEPTB;MkS1MlU3KG6P NYjQTFkzW0GQR1XS
NCI-H522 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTJ2OD6zNUBvVQ>? NV:wOHBnW0GQR1XS
A388 NHf0OVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJ2OT64NkBvVQ>? MlXmV2FPT0WU
GOTO MluwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7sTWM2OD1{NUCuNlkhdk1? Mmr4V2FPT0WU
KLE M4HYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33tPWlEPTB;MkWxMlg4KG6P MlfuV2FPT0WU
KYSE-520 NYfHTnhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ3Mj64OkBvVQ>? NGrmW2ZUSU6JRWK=
HCE-4 NUX0RZRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH64XHBKSzVyPUK2Nk42KG6P MWrTRW5ITVJ?
KURAMOCHI MkTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\GOnB5UUN3ME2yOlUvQSCwTR?= Mn[2V2FPT0WU
HCC38 M3K2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i1XmlEPTB;Mk[2MlQ5KG6P Mn3yV2FPT0WU
FADU MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDpT3FKSzVyPUK2Ok43OyCwTR?= MX7TRW5ITVJ?
CW-2 NFThdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1q0VmlEPTB;Mk[5Mlk3KG6P M{nlNnNCVkeHUh?=
L-428 NF3GTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTJ5NT6xOUBvVQ>? NUe2SXY5W0GQR1XS
HCC1569 NGXNZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD6UJF{UUN3ME2yO|UvQDRibl2= M4iyOnNCVkeHUh?=
NCI-H810 MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnOTWM2OD1{N{iuN|Ehdk1? M1vxXHNCVkeHUh?=
LB771-HNC NHvoOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\V[2FiUUN3ME2yPFUvQDRibl2= MUXTRW5ITVJ?
LCLC-103H MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r0emlEPTB;Mki1Mlk6KG6P MX3TRW5ITVJ?
EFO-21 M3nwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7RUXNpUUN3ME2yPFcvPjhibl2= NVi5flBbW0GQR1XS
CAL-72 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;ZPW5vUUN3ME2yPVMvOTlibl2= NYHyXZBrW0GQR1XS
SCC-9 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnV[phmUUN3ME2yPVMvOjJibl2= MWTTRW5ITVJ?
COLO-829 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7pTWM2OD1{OU[uOUBvVQ>? MVzTRW5ITVJ?
U-87-MG NWrZfG8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTNyMD63N{BvVQ>? NYDYNpRxW0GQR1XS
MZ7-mel Mn64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7nTWM2OD1|MkOuO|Yhdk1? NHPLNFBUSU6JRWK=
NCI-H1770 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTiTWM2OD1|Mk[uO|Qhdk1? NWKwN4JCW0GQR1XS
ChaGo-K-1 NWDKZlZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\5PZVKSzVyPUOyPE4yKG6P NFS1fItUSU6JRWK=
SiHa M1LrU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDR[|BKSzVyPUOyPU4zPCCwTR?= NH3FR2dUSU6JRWK=
NCI-SNU-5 M2P1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTMWHlKSzVyPUOzOk44PyCwTR?= M2rvO3NCVkeHUh?=
DJM-1 NX7hcZA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\uXJRKSzVyPUO0NE4{OyCwTR?= MXnTRW5ITVJ?
OE19 M3Wyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF6xVYZKSzVyPUO0NE42OyCwTR?= MnW0V2FPT0WU
NCI-H1651 M3TlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvkTXZKSzVyPUO0OE4yQCCwTR?= NIHXTGhUSU6JRWK=
COLO-792 NFHyPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrGTWM2OD1|NUSuOFIhdk1? NXHvXFNvW0GQR1XS
ACHN NWq0VZJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnBfHZzUUN3ME2zOVYvPzFibl2= MknDV2FPT0WU
TH-3 NFz4THFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTN5OT65OUBvVQ>? Mn36V2FPT0WU
HT-1376 NHvqU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzLfHlKSzVyPUO4OE45QCCwTR?= M{L0NHNCVkeHUh?=
RH-18 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTEeI5ZUUN3ME2zPVQvPzRibl2= MoLrV2FPT0WU
NB6 NVLIRXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTN7Nj62OkBvVQ>? NHzhN41USU6JRWK=
COLO-320-HSR M4PuS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLOW4lKSzVyPUSwN{4{PyCwTR?= M2X0dXNCVkeHUh?=
UACC-893 NV3iZ3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELDOo1KSzVyPUSwOk41PyCwTR?= MmHrV2FPT0WU
DSH1 NUK1TGNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFP0bY5KSzVyPUSwOk46OSCwTR?= NEnZ[oJUSU6JRWK=
TE-10 NVLycIZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jsfWlEPTB;NEC3MlAyKG6P NXXwVHJCW0GQR1XS
HCC70 M{TzUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGxTWM2OD12MEmuNlEhdk1? M3z4b3NCVkeHUh?=
TGBC11TKB NEmxTmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7mTWM2OD12MUCuN|Mhdk1? NVP5bmo6W0GQR1XS
NCI-H727 MoDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTRzMj6xNUBvVQ>? MXfTRW5ITVJ?
ALL-PO NHmweVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjRcmVKSzVyPUSxOU43QSCwTR?= MmPZV2FPT0WU
ABC-1 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HPWGlEPTB;NEKwMlQ2KG6P MkG5V2FPT0WU
NCI-H69 MmLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFztSnJKSzVyPUSyOk44PiCwTR?= MmP3V2FPT0WU
GP5d MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jBc2lEPTB;NEO0MlQyKG6P MYjTRW5ITVJ?
UMC-11 NHrDc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7MN5RrUUN3ME20OVgvOzZibl2= MWrTRW5ITVJ?
RMG-I MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHtTWM2OD12NkeuOVYhdk1? Mo\uV2FPT0WU
YAPC NELIUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfVe2JKSzVyPUS5NE43KG6P MWjTRW5ITVJ?
LS-1034 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTR7MT6wOkBvVQ>? NXvQRW1rW0GQR1XS
RCM-1 NFXue|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLZTWM2OD12OU[uOlghdk1? NWjiZXhzW0GQR1XS
HCC1954 NXL6N5NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTVzMj61JI5O M{nRS3NCVkeHUh?=
SK-MEL-24 NH;GRodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTVzNj61NUBvVQ>? MlTTV2FPT0WU
NB12 NXTzPJluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHwNmNKSzVyPUWyPE41OiCwTR?= NHPVSlBUSU6JRWK=
SW756 M2rzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkCyTWM2OD13NUSuPVYhdk1? NIPid4xUSU6JRWK=
HCC1187 M{fZOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTV5NT64N{BvVQ>? M1W4NHNCVkeHUh?=
NCI-H2342 M2DjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHOfXBKSzVyPUW5NE4{QSCwTR?= NVTSb|FqW0GQR1XS
NCI-H2291 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXLTWM2OD13OUiuN|Ehdk1? M2DYcHNCVkeHUh?=
OVCAR-3 M1PTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTV7OD65OkBvVQ>? NWrrcJBPW0GQR1XS
MHH-NB-11 NIm5flhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPIc|Z1UUN3ME22NlkvODFibl2= NIH5XJFUSU6JRWK=
SAS MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XFfWlEPTB;NkWyMlY4KG6P MkXOV2FPT0WU
COLO-824 M{S3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTZ6OT6zO{BvVQ>? MlfOV2FPT0WU
HCC1395 NHrFbopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WzT2lEPTB;Nkm4MlUhdk1? NGXGN2tUSU6JRWK=
COLO-668 NEn1UZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTdyNj6xJI5O M2D5enNCVkeHUh?=
NCI-H226 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\nWVRKSzVyPUewO{45KG6P NUPlc5dWW0GQR1XS
NB17 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnMZYd5UUN3ME23NlEvPzVibl2= M3T4N3NCVkeHUh?=
SW1463 M3vkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHmXY1LUUN3ME23N|kvOTlibl2= NH;KTlRUSU6JRWK=
TGW NWHGclNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTd4MD6xOUBvVQ>? NYrNTmVpW0GQR1XS
NCI-H526 NGnH[nJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTh{Mz61N{BvVQ>? Mn\3V2FPT0WU
COR-L88 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW1dJJKSzVyPUi0PE4yOiCwTR?= NVTjWmE3W0GQR1XS
NCI-H441 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\mTWM2OD16OUWuNlIhdk1? M3PhZ3NCVkeHUh?=
NCI-H630 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLUdY5KSzVyPUmxNk46PiCwTR?= Mly5V2FPT0WU
Mo-T NH7JWoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PHU2lEPTB;OUS3Mlg5KG6P NXLC[nZRW0GQR1XS
JAR M2iy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LwOmlEPTB;OUW2MlI1KG6P NHPNZlBUSU6JRWK=
NCI-H1838 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm2e3UxUUN3ME2xMlAzOzh6IN88US=> NEXqZ|NUSU6JRWK=
DoTc2-4510 NEGyWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCwTWM2OD1zLkC3N|c3KM7:TR?= MlqyV2FPT0WU
MKN28 MofPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TFS2lEPTB;MT6wPVAzPCEQvF2= NV:0bpBiW0GQR1XS
HuP-T3 M{jhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXvT3JKSzVyPUGuNVE6ODVizszN MnH6V2FPT0WU
TE-9 NVTZTHpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV24RVN{UUN3ME2xMlEzQTd|IN88US=> M3XDXXNCVkeHUh?=
NY M1XwRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HicGlEPTB;MT6xOlc6OiEQvF2= MUfTRW5ITVJ?
HT55 NFuzbmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PQVGlEPTB;MT6zNVM1PCEQvF2= M4TrdnNCVkeHUh?=
SW837 M3rCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3XTWM2OD1zLkOyPVc5KM7:TR?= M2O4SHNCVkeHUh?=
NCI-H2029 NGHqXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrjVpZ3UUN3ME2xMlQyPzlzIN88US=> M4XNTHNCVkeHUh?=
IST-SL1 NVvUVoRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTFwNESyOEDPxE1? M2LCeXNCVkeHUh?=
COLO-741 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XLXWlEPTB;MT60PVc4OSEQvF2= NVPXOpgzW0GQR1XS
LU-65 NF[zXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfUfXdpUUN3ME2xMlYzOjR7IN88US=> Mn7tV2FPT0WU
NCI-H1304 NGP2ZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTFwNkW0PVgh|ryP M2PPcXNCVkeHUh?=
KARPAS-299 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHQTWM2OD1zLke5OFc6KM7:TR?= M3L1bHNCVkeHUh?=
NCI-H358 NXHuWGtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jYXGlEPTB;MT65OVUxOyEQvF2= MnLuV2FPT0WU
OAW-28 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLTTWM2OD1{LkC2PVE6KM7:TR?= NFXoc5RUSU6JRWK=
C8166 MnrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLEU4R3UUN3ME2yMlY{Ozl{IN88US=> MYTTRW5ITVJ?
COLO-678 M1\JXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDBXGNKSzVyPUKuPFM4PjhizszN NFX5e21USU6JRWK=
SK-N-DZ NEj0W4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPkTWM2OD1{Lki2N|gyKM7:TR?= MXXTRW5ITVJ?
NCI-H82 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHiSGNKSzVyPUKuPVA{PjlizszN MmXZV2FPT0WU
JVM-2 M2CzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID1ZoJKSzVyPUOuNFMyQDhizszN MVvTRW5ITVJ?
SW1116 NEj1OIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXOSJVKSzVyPUOuNFU1OTFizszN MXLTRW5ITVJ?
MDA-MB-453 NG\BZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLodmFKSzVyPUOuNVA1OzlizszN NV3JTZpTW0GQR1XS
Calu-6 M{L4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rTemlEPTB;Mz6xPVk4KM7:TR?= NYT3[JZCW0GQR1XS
SHP-77 NY[xPZJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPWTWM2OD1|LkWyPEDPxE1? M37CUXNCVkeHUh?=
Capan-2 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTRwM{K1PFEh|ryP NF61Um5USU6JRWK=
SW948 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[yRm9XUUN3ME20Mlc1Pzd7IN88US=> MWfTRW5ITVJ?
HDLM-2 NX\ZXHpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTZcZNKSzVyPUWuNFc4OjVizszN M1nOOXNCVkeHUh?=
LAN-6 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLmSW55UUN3ME22MlIyPDl3IN88US=> NV;xS|dwW0GQR1XS
LU-135 NEjENm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTZwNEOwO|ch|ryP M2TZNnNCVkeHUh?=
T84 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ezZ2lEPTB;Nj65PFY1KM7:TR?= NX\1VndtW0GQR1XS
CAPAN-1 M2[4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTdwNkKyN|Mh|ryP MXfTRW5ITVJ?
SW1417 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVToc3ZyUUN3ME23MlkyPzNzIN88US=> MYPTRW5ITVJ?
BALL-1 NFi0em9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRThwNUC0NFkh|ryP MoD1V2FPT0WU
HT-29 M2DvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTlwMEe1PVkh|ryP MoHkV2FPT0WU
C3A M1vNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvqS2JEUUN3ME25Mlg5Ozl2IN88US=> MnnPV2FPT0WU
NCI-H1993 NELqUWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zGV2lEPTB;MUCuOVA5OSEQvF2= MV\TRW5ITVJ?
SK-MEL-1 NHvwemFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13GZmlEPTB;MUGuOlI5QSEQvF2= Mk\mV2FPT0WU
DU-145 NIjxRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M121b2lEPTB;MUSuOVA2OiEQvF2= M4K5[nNCVkeHUh?=
KP-N-YN NUixUYVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGSzXWpKSzVyPUG0MlUyODNizszN NFG0OHhUSU6JRWK=
CCRF-CEM MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HHOGlEPTB;MUSuO|gxQSEQvF2= MV7TRW5ITVJ?
ZR-75-30 NFXPUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nMPWlEPTB;MU[uN|MxOyEQvF2= NVS0eZN6W0GQR1XS
A673 M2DpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XTVGlEPTB;MkCuOVUxPyEQvF2= NFfwVnJUSU6JRWK=
K-562 MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvXfm56UUN3ME2yPE41OTh|IN88US=> MYrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Myc / Vinculin / pT58 Myc; 

PubMed: 25934076     


Immunoblots documenting MYC and pT58 MYC stability. SW480 cells were treated with 200nM BEZ235 or solvent control for 24h and cycloheximide (50µg/ml) and harvested at the indicated time points. Vinculin was used as loading control. Exposures of MYC and pT58 MYC blots were adjusted to equalize exposure at 0 min (n=3; unless otherwise indicated, n indicates the number of independent biological repeat experiments in the following legends).

pAkt / Akt / Skp2 / AR / pS6 / p27; 

PubMed: 24347472     


BEZ235 decreases Skp2 and increases AR protein expression inC4-2B cells. Cells were treated with BEZ235 at various doses. Cell lysates were subjected to Westernblot analysis with indicated antibodies. 

p-S6K / S6K / p-Akt / Akt / p-ABL / BCR-ABL; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the phosphorylation levels of S6K, Akt (Ser473), and BCR–ABL in CML cells. Results of Western blot.

Bcl-2 / Caspase-3 / Cleaved caspase-3 ; 

PubMed: 28435223     


K562 (A1) and KBM7R (A2) cells were treated with BEZ235 for 24 h; total protein lysates were immunoblotted with antibodies for Bcl-2, caspase-3, and cleaved caspase-3. 

Cyclin D1 / Cyclin D2 ; 

PubMed: 28435223     


Dose-dependent inhibition effect of BEZ235 on the expression levels of cyclin D1 and cyclin D2 in K562 and KBM7R cells. Western blot results of K562 (A1) and KBM7R (A2) cells.

mTOR / p-mTOR / p70S6K / p-p70S6K ; 

PubMed: 29581778     


Eca-109 cells was treated with increasing concentration of BEZ235 (0, 100, 200 and 500 nM) for 48 hours. Western blot showed the inhibition effect of PI3K/mTOR pathway was dose dependent. 

p-EGFR-Tyr1068 / EGFR / p-HER2-Tyr1221 / p-HER2-Tyr1222 / HER2 / p-HER3-Tyr1289; 

PubMed: 21278786     


Immunoblots of protein lysates from BT474 and MCF7-HER2 cells treated with either BEZ235 alone (0–500 n) or the combination of BEZ235 (0–500 n) and the tyrosine kinase inhibitor lapatinib (LAP, 500 n) for 24 h. 

25934076 24347472 28435223 29581778 21278786
Immunofluorescence
SP1; 

PubMed: 26336820     


Immunofluorescence assessment of SP1 after BEZ235 treatment for 24 hrs in A673, SKNMC cells and in HFF.

p-ErbB2(Y1248); 

PubMed: 24675532     


Immunofluorescence staining of BT474.LapR cells grown in 3-D culture under different treatment conditions for a week. Scale bar indicates 50 μm.

LC3; 

PubMed: 23603977     


(A) SU-2 cells were treated with NVP-BEZ235 (10 nmol/L) for 12 h and then harvested 24 h after treatment with IR (8 Gy), and analyzed for LC3 expression (top) or the formation of autophagolysosomes by using MDC (middle) and LTR (bottom) by immunofluorescence analysis (600×magnification).

26336820 24675532 23603977
Growth inhibition assay
Cell viability (P3, U87); 

PubMed: 27542970     


IC50 doses of dactolisib for P3 (left) and U87 (right) glioma cells, generated from MTS assay. 

Cell viability (breast cancer cells); 

PubMed: 28060760     


Cell viability of breast cancer cells treated by either BEZ235 or TSA for 48h was measured by MTT assay. Each cell line was analyzed in triplicate, and a representative experiment is shown. 

Cell viability (K562, KBM7R); 

PubMed: 28435223     


(A) K562 cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (B) KBM7R cells were treated with increasing concentrations of BEZ235 for 24, 48, or 72 h and subjected to MTS assay. (C) K562 cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. (D) KBM7R cells were treated with imatinib (0–10 μM) alone or imatinib and BEZ235 (0.2 μM) for 48 h and subjected to MTS assay. Mean ± SD. n=3. *P<0.05, compared to the control group. #P<0.05, compared to the group of IM alone.

27542970 28060760 28435223
ELISA
VEGF; 

PubMed: 19671762     


NVP-BEZ235 attenuated VEGF secretion by at least 40% in U87 cells. The VEGF level in the serum-free medium was measured in triplicate and the experiment repeated at least twice to confirm results.

19671762
In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

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In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

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  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Female Harlan athymic nude mice
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+PEG300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms NVP-BEZ235
Smiles CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01856101 Terminated Drug: BEZ235 Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Drug: BEZ235|Drug: Prednisone|Drug: Abiraterone acetate Castrate-resistant Prostate Cancer Charles Ryan|Novartis Pharmaceuticals|University of California San Francisco January 31 2013 Phase 1|Phase 2
NCT01756118 Unknown status Drug: BEZ235 Acute Lymphoblastic Leukemia|Leukemia Myelocytic Acute|Chronic Myelogenous Leukemia With Crisis of Blast Cells Johann Wolfgang Goethe University Hospital June 2012 Phase 1
NCT01290406 Withdrawn Drug: BEZ235 Endometrial Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2
NCT01288092 Withdrawn Drug: BEZ235 Metastatic Breast Cancer Novartis Pharmaceuticals|Novartis March 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID