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Catalog No.S1747 Synonyms: BAY E 9736

3 publications

Nimodipine Chemical Structure

CAS No. 66085-59-4

Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

Selleck's Nimodipine has been cited by 3 publications

1 Customer Review

  • Assessment of the role of Ca2+ channels during RSV replication. HEp-2 cells were infected with RSV strain long at an MOI of 0.1, and treated with calcium channel blockers nifedipine, nimodipine, and tetrandrine (A), at indicated concentrations. Supernatants were collected at 48 h postinfection and viral titers were determined by immunoplaque assay. Grey bars represent cytotoxicity of the compounds. The data presented were obtained from two independent experiments. Error bars represent the standard deviations from two independent experiments. NS, no differences at a significance level of 0.05.

    Antiviral Res, 2016, 132:38-45.. Nimodipine purchased from Selleck.

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Biological Activity

Description Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
Calcium channel [1]
In vitro

Nimodipine decreases both the peak amplitude and the integrated area of the AHP in an age- and concentration-dependent manner. Nimodipine (100 nM) significantly reduces the AHP in aging CA1 neurons. Nimodipine increases excitability in an age- and concentration-dependent manner by decreasing spike frequency accommodation (increasing the number of action potentials during prolonged depolarizing current injection). Nimodipine decreases accommodation only at higher concentrations in young CA1 neurons. [1] Nimodipine decreases the plateau phase of the calcium AP at concentrations as low as 100 nM in aging neurons and 10 mM in young rat neurons. [2]

In vivo Nimodipine results in reversible, dose-related suppression of the compound action potential of the auditory nerve (CAP; N1-P1), a prolongation of N1 latency at suprathreshold levels, an elevated CAP threshold, a decrease in N1 latency at a constant amplitude measured at CAP threshold, a reduction in cochlear microphonics (CM), and a reduction of the negative summating potential (SP) to a point where it becomes positive. [3] Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, appears to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine. [4] Nimodipine (5-20 mg/kg, SC) inhibits in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. [5]


Solubility (25°C)

In vitro DMSO 84 mg/mL (200.74 mM)
Ethanol 84 mg/mL (200.74 mM)
Water Insoluble

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Chemical Information

Molecular Weight 418.44


CAS No. 66085-59-4
Storage powder
in solvent
Synonyms BAY E 9736
Smiles CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04998370 Recruiting -- Subarachnoid Hemorrhage Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit University of Zurich August 2021 --
NCT04649398 Recruiting Drug: Nimodipine Subarachnoid Hemorrhage Aneurysmal|Delayed Cerebral Ischemia|Vasospasm Cerebral Medical University of Vienna|University of Vienna|Austrian Science Fund (FWF) November 25 2020 --
NCT02991157 Completed Drug: Nimodipine Subarachnoid Hemorrhage Aneurysmal National Institute of Mental Health and Neuro Sciences India December 2016 --
NCT01835665 Completed Drug: Nimodipine Progranulin Mutation Carriers University of California San Francisco|The Bluefield Project to Cure Frontotemporal Dementia March 2013 Phase 1
NCT01551368 Terminated Drug: Nimodipine|Drug: Placebo Infertility Mount Sinai Hospital Canada December 2012 Phase 2
NCT01220622 Unknown status Drug: Nimodipine|Drug: Placebo Stroke|Mild Cognitive Impairment Ministry of Science and Technology of the People´s Republic of China October 2010 Phase 4

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID