Gemcitabine (LY-188011) HCl

Name: Gemcitabine (LY-188011) HCl
Brand: Selleck Chemicals
SKU: S1149
Rating: 5 (116 reviews)

For research use only.

Catalog No.S1149 Synonyms: NSC 613327

116 publications

Gemcitabine (LY-188011) HCl Chemical Structure

CAS No. 122111-03-9

Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Selleck's Gemcitabine (LY-188011) HCl has been cited by 116 publications

Cancer Cell, 2019, 35(3):519-533

PubMed: 30889383 ( click the link to review the publication )

Nat Commun, 2021, 12(1):4917

PubMed: 34389714 ( click the link to review the publication )

Nat Commun, 2021, 12(1):1602

PubMed: 33707442 ( click the link to review the publication )

Cancer Res, 2021, canres.1337.2021

PubMed: 34580061 ( click the link to review the publication )

Mol Cancer, 2021, 20(1):97

PubMed: 34315482 ( click the link to review the publication )

Oncogene, 2021, 10.1038/s41388-021-01992-2

PubMed: 34400766 ( click the link to review the publication )

Oncogene, 2021, 10.1038/s41388-020-01634-z

PubMed: 33452459 ( click the link to review the publication )

Cancers (Basel), 2021, 13(17)4405

PubMed: 34503215 ( click the link to review the publication )

Cancers (Basel), 2021, 13(11)2539

PubMed: 34064221 ( click the link to review the publication )

Cell Death Dis, 2021, 12(8):772

PubMed: 34354046 ( click the link to review the publication )

Cell Death Dis, 2021, 12(1):72

PubMed: 33436545 ( click the link to review the publication )

Neoplasia, 2021, 23(7):643-652

PubMed: 34126361 ( click the link to review the publication )

Oxid Med Cell Longev, 2021, 2021:6673828

PubMed: 34055197 ( click the link to review the publication )

Int J Mol Sci, 2021, 22(13)6825

PubMed: 34201963 ( click the link to review the publication )

Sci Rep, 2021, 11(1):10181

PubMed: 33986399 ( click the link to review the publication )

Invest New Drugs, 2021, 10.1007/s10637-020-01003-3

PubMed: 33475937 ( click the link to review the publication )

J Pharm Biomed Anal, 2021, 198:114025

PubMed: 33744463 ( click the link to review the publication )

Hum Cell, 2021, 10.1007/s13577-021-00579-z

PubMed: 34304386 ( click the link to review the publication )

BMC Urol, 2021, 21(1):96

PubMed: 34210300 ( click the link to review the publication )

Cancer Med, 2021, 10.1002/cam4.3739

PubMed: 33626233 ( click the link to review the publication )

Cancers (Basel), 2021, 13(3)527

PubMed: 33573176 ( click the link to review the publication )

Nat Commun, 2020, 11(1):3018

PubMed: 32541668 ( click the link to review the publication )

Nat Commun, 2020, 12;11(1):2971

PubMed: 32532990 ( click the link to review the publication )

Nat Commun, 2020, 10;11(1):2935

PubMed: 32523045 ( click the link to review the publication )
Nat Commun, 2020, 14;11(1):1825

PubMed: 32286280 ( click the link to review the publication )

Nat Commun, 2020, 24;11(1):1975

PubMed: 32332851 ( click the link to review the publication )

Clin Cancer Res, 2020, 27 pii: clincanres

PubMed: 32341033 ( click the link to review the publication )

Mol Syst Biol, 2020, 16(2):e8664

PubMed: 32073727 ( click the link to review the publication )

Oncogene, 2020, 10.1038/s41388-020-1364-7

PubMed: 32561852 ( click the link to review the publication )

Cancers (Basel), 2020, 12(12)E3816

PubMed: 33348809 ( click the link to review the publication )

Cancers (Basel), 2020, 15;12(4) pii: E974

PubMed: 32326402 ( click the link to review the publication )

Neoplasia, 2020, 22(1):22-32

PubMed: 31765939 ( click the link to review the publication )

Am J Cancer Res, 2020, 10(10):3302-3315

PubMed: 33163271 ( click the link to review the publication )

Int J Mol Sci, 2020, 21(23)E9034

PubMed: 33261142 ( click the link to review the publication )

Sci Rep, 2020, 10(1):18489

PubMed: 33116269 ( click the link to review the publication )

Sci Rep, 2020, 15;10(1):337

PubMed: 31941932 ( click the link to review the publication )

J Biol Chem, 2020, 1 pii: jbc

PubMed: 32358063 ( click the link to review the publication )

Food Chem Toxicol, 2020, 147:111919

PubMed: 33301843 ( click the link to review the publication )

BMC Cancer, 2020, 20(1):984

PubMed: 33046037 ( click the link to review the publication )

Cancer Res Treat, 2020, 10.4143/crt.2020.585

PubMed: 33070556 ( click the link to review the publication )

Med Sci Monit, 2020, 26:e922703

PubMed: 32946432 ( click the link to review the publication )

Anticancer Res, 2020, 40(7):3659-3667

PubMed: 32620605 ( click the link to review the publication )

J Biochem Mol Toxicol, 2020, e22621

PubMed: 32894642 ( click the link to review the publication )

Mediators Inflamm, 2020, 2020:8567320

PubMed: 32684837 ( click the link to review the publication )

Genes Chromosomes Cancer, 2020, 10.1002/gcc.22884

PubMed: 32614991 ( click the link to review the publication )

Am J Transl Res, 2020, 12(6):2827-2842

PubMed: 32655813 ( click the link to review the publication )

bioRxiv, 2020, 2020/9/20.4.7.30734

PubMed: 32511305 ( click the link to review the publication )

J Immunother Cancer, 2019, 7(1):199

PubMed: 31362778 ( click the link to review the publication )
J Control Release, 2019, 305:89-100

PubMed: 31096017 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)E2042

PubMed: 31861153 ( click the link to review the publication )

Cancers (Basel), 2019, 11(12)E1835

PubMed: 31766357 ( click the link to review the publication )

Cells, 2019, 8(8)

PubMed: 31390735 ( click the link to review the publication )

Cell Prolif, 2019, 52(1):e12514

PubMed: 30341797 ( click the link to review the publication )

Cancer Sci, 2019, 110(1):334-344

PubMed: 30353606 ( click the link to review the publication )

Int J Biol Sci, 2019, 15(9):1771-1786

PubMed: 31523182 ( click the link to review the publication )

Invest New Drugs, 2019, 10.1007/s10637-019-00839-8

PubMed: 31463638 ( click the link to review the publication )

BMC Cancer, 2019, 19(1):604

PubMed: 31216997 ( click the link to review the publication )

Biosci Rep, 2019, 10.1042/BSR20192358

PubMed: 31693728 ( click the link to review the publication )

Exp Ther Med, 2019, 18(1):550-558

PubMed: 31258693 ( click the link to review the publication )

Nanomedicine (Lond), 2019, 14(15):1971-1989

PubMed: 31355712 ( click the link to review the publication )

Nat Commun, 2018, 13;9(1):2720

PubMed: 30006524 ( click the link to review the publication )

Nat Commun, 2018, 9(1):2434

PubMed: 29934552 ( click the link to review the publication )

Cancer Res, 2018, 78(19):5656-5667

PubMed: 30217928 ( click the link to review the publication )

Oncogene, 2018, 37(44):5843-5857

PubMed: 29980787 ( click the link to review the publication )

Sci Signal, 2018, 11(540)eaat0229

PubMed: 30042127 ( click the link to review the publication )

Cancers (Basel), 2018, 10(5)

PubMed: 29783721 ( click the link to review the publication )

Mol Ther Nucleic Acids, 2018, 13:472-482

PubMed: 30388621 ( click the link to review the publication )

Cell Chem Biol, 2018, 25(6):705-717

PubMed: 29628435 ( click the link to review the publication )

J Adv Res, 2018, 15:59-68

PubMed: 30581613 ( click the link to review the publication )

Neoplasia, 2018, 20(8):826-837

PubMed: 30015158 ( click the link to review the publication )

Oxid Med Cell Longev, 2018, 2018:9482018

PubMed: 29765509 ( click the link to review the publication )

Oxid Med Cell Longev, 2018, 2018:2360427

PubMed: 29849873 ( click the link to review the publication )
Int J Mol Sci, 2018, 19(10)

PubMed: 30274301 ( click the link to review the publication )

Int J Mol Sci, 2018, 19(2)

PubMed: 29462944 ( click the link to review the publication )

J Biol Chem, 2018, 293(3):984-994

PubMed: 29191829 ( click the link to review the publication )

Apoptosis, 2018, 23(5-6):343-355

PubMed: 29740790 ( click the link to review the publication )

Pharm Res, 2018, 35(8):154

PubMed: 29855807 ( click the link to review the publication )

Dig Dis Sci, 2018, 63(12):3367-3375

PubMed: 30155839 ( click the link to review the publication )

Cancer Biomark, 2018, 10.3233/CBM-181182

PubMed: 29526843 ( click the link to review the publication )

Anticancer Res, 2018, 38(4):1967-1977

PubMed: 29599312 ( click the link to review the publication )

Oncol Lett, 2018, 15(5):6107-6114

PubMed: 29731842 ( click the link to review the publication )

Cancer Lett, 2017, 411:106-116

PubMed: 28947137 ( click the link to review the publication )

Cell Death Dis, 2017, 8(10):e3129

PubMed: 29048402 ( click the link to review the publication )

Cell Death Dis, 2017, 8(5):e2770

PubMed: 28492560 ( click the link to review the publication )

Br J Cancer, 2017, 116(3):324-334

PubMed: 28056464 ( click the link to review the publication )

Mol Oncol, 2017, 11(9):1130-1142

PubMed: 28544747 ( click the link to review the publication )

FEBS J, 2017, 284(2):222-236

PubMed: 27860276 ( click the link to review the publication )

J Cell Mol Med, 2017, 21(9):2055-2067

PubMed: 28244691 ( click the link to review the publication )

PLoS One, 2017, 12(11):e0188859

PubMed: 29186204 ( click the link to review the publication )

Acta Biochim Biophys Sin (Shanghai), 2017, 49(7):573-580

PubMed: 28475672 ( click the link to review the publication )

Oncotarget, 2017, 8(35):58417-58429

PubMed: 28938567 ( click the link to review the publication )

J Pineal Res, 2016, 60(1):27-38

PubMed: 26445000 ( click the link to review the publication )

Cancer Res, 2016, 76(13):3978-88

PubMed: 27216178 ( click the link to review the publication )

Cancer Lett, 2016, 380(2):434-41

PubMed: 27400681 ( click the link to review the publication )

Antiviral Res, 2016, 126:69-80

PubMed: 26738783 ( click the link to review the publication )

Am J Pathol, 2016, 186(6):1537-46

PubMed: 27102771 ( click the link to review the publication )
PLoS One, 2016, 11(6):e0158617

PubMed: 27359113 ( click the link to review the publication )

Tumour Biol, 2016, 37(9):12731-12742

PubMed: 27448305 ( click the link to review the publication )

Sci Transl Med, 2015, 7(284):284ra57

PubMed: 25904741 ( click the link to review the publication )

Mol Cancer Ther, 2015,

PubMed: 25344582 ( click the link to review the publication )

Cancer Sci, 2015, 106(1):9-17

PubMed: 25363339 ( click the link to review the publication )

Biomedicine & Pharmacotherapy, 2015, 73:123-8

PubMed: 26211592 ( click the link to review the publication )

Eur J Pharmacol, 2015, 10.1016/j.ejphar.2015.03.064

PubMed: 25843411 ( click the link to review the publication )

PLoS One, 2015, 10(4):e0123901

PubMed: 25875914 ( click the link to review the publication )

Anticancer Drugs, 2015, 26(6):612-9

PubMed: 25734833 ( click the link to review the publication )

Nucleic Acids Res, 2014, 42(10):6436-47

PubMed: 24728989 ( click the link to review the publication )

Clin Cancer Res, 2014, 20(12):3187-97

PubMed: 24838526 ( click the link to review the publication )

J Immunol, 2014, 192(9):4273-83

PubMed: 24670807 ( click the link to review the publication )

Mol Pharmacol, 2014, 85(3):408-19

PubMed: 24353313 ( click the link to review the publication )

Pancreas, 2014, 44(1):144-151

PubMed: 25237909 ( click the link to review the publication )

Freien Universit, 2014, Christian K?hler

PubMed: ( click the link to review the publication )

Cell Death Dis, 2013, 4:e742

PubMed: 23887633 ( click the link to review the publication )

Cancer Immunol Immun, 2013, 62(2):383-91

PubMed: 22926062 ( click the link to review the publication )

Biochemistry, 2013, 52(40):7050-9

PubMed: 24024562 ( click the link to review the publication )

Sci Signal, 2011, 1(4):352-65

PubMed: 22145099 ( click the link to review the publication )

Pancreas, 2011, 40(5):730-9

PubMed: 21633318 ( click the link to review the publication )

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description

Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Features

Gemcitabine has been used to treat pancreatic cancer and has demonstrated effective anti-tumor activity.

Targets

DNA synthesis (Capan2 cells) ^[1]	DNA synthesis (BxPC3 cells) ^[1]	DNA synthesis (MIAPaCa2 cells) ^[1]	DNA synthesis (PANC1 cells) ^[1]
12 nM	18 nM	40 nM	50 nM

In vitro

Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Treatment of BxPC-3 cells with low dose Gemcitabine for 48 hours results in a dose-dependent increase in NF-κB binding. In contrast, NF-κB DNA binding is decreased in BxPC-3 cells treated with the higher Gemcitabine doses for 48 h; however, 24-h treatment with these higher doses increases NF-κB binding in BxPC-3 cells ^[2]

Cell Data

Cell Lines	Assay Type	Incubation Time	Activity Description	PMID
CCRF-CEM	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MXvJR\|UxRTJwOTFCtUAyNjhibl2=	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR{NUi4OUc,OjJ2MkW4PFU9N2F-
CCRF-CEM/dCK−/−	NHfiXYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MWHJR\|UxRTJ2MD60JOKyKDJ7LkCg{txO	NX3lZ25iRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0NlU5QDVpPkKyOFI2QDh3PD;hQi=>
L1210 wt	MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MkLCTWM2OD1zLkOgxtEhOC5\|IH7N	M13ZPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEK1PFg2Lz5{MkSyOVg5PTxxYU6=
L1210 10K	NX:zO5ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MVvJR\|UxRTJ{LkKgxtEhOy55IN88US=>	NGTXRoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSyOVg5PSd-MkK0NlU5QDV:L3G+
TC-1	NYKwPY5TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NGTRSWZKSzVyPUG0MlchyrFiMj64JI5O	NYfSR2pmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0NlU5QDVpPkKyOFI2QDh3PD;hQi=>
TC-1-GR	NGXxeYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MojlTWM2OD1\|Nj63JOKyKDVwMTFOwG0>	M1fBbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEK1PFg2Lz5{MkSyOVg5PTxxYU6=
MIA PaCa-2	NGPibXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M1fub2lEPTB;NEmuO{DDuSBzNz63JI5O	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR{NUi4OUc,OjJ2MkW4PFU9N2F-
PANC-1	M373Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MoHCTWM2OD1-IESwNEDPxE1?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR{NUi4OUc,OjJ2MkW4PFU9N2F-
CCRF-CEM	MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M{LOZWlEPTB;Mj65JOKyKDFwODDuUS=>	NFzpZm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSyOVg5PSd-MkK0NlU5QDV:L3G+
CCRF-CEM-AraC-8C	NWX1OolOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NGHQRZlKSzVyPUm5PE45KMLzIEmuOEBvVQ>?	M4XUd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEK1PFg2Lz5{MkSyOVg5PTxxYU6=
CCRF-CEM	MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MorsO\|IhcA>?	NY[yVWxWUUN3ME2yMlAhyrFiMD62JI5O	NEXyNZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUi1NVg1Oyd-MkG4OVE5PDN:L3G+
MV-4-11	NUHkPVBDT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NF7B[\|VKSzVyIE2gNE4xODB3IH7N	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
ES4	MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M{nJ[2lEPTBiPTCwMlAxODdibl2=	NIXBV2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
ACHN	MYHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NI\mVHFKSzVyIE2gNE4xODB7IH7N	MkHrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
KYSE-510	Mor5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NUHUUoI{UUN3MDC9JFAvODBzIH7N	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
EW-7	MnS3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		NV3KTnlxUUN3MDC9JFAvODB{NjDuUS=>	NUT2enIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
BFTC-905	NEHIbHhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NYnEeGFNUUN3MDC9JFAvODB3MTDuUS=>	M2WxfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
KE-37	NYDmN451T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NWLMdVNqUUN3MDC9JFAvODB3NjDuUS=>	NXz1ZpczRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
SBC-5	M3XxdGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M4nMc2lEPTBiPTCwMlAxPTdibl2=	NUPOPHRYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
NKM-1	MkewS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MV7JR\|UxKD1iMD6wNFcyKG6P	M1LKbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
RH-1	M1jhb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MXzJR\|UxKD1iMD6wNFczKG6P	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
ALL-PO	M371cWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NYrRfm1pUUN3MDC9JFAvODB6MzDuUS=>	NILYcm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
QIMR-WIL	MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MUfJR\|UxKD1iMD6wNFg6KG6P	MnnLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
A375	NYSzcnNwT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NIfad\|lKSzVyIE2gNE4xODl7IH7N	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
SIG-M5	MmrKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MU\JR\|UxKD1iMD6wNVA1KG6P	NUnPVpR[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
KGN	NYfNWFExT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MkDSTWM2OCB;IECuNFExQCCwTR?=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
EW-13	NXfuUpN[T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M3nVfGlEPTBiPTCwMlAyOTJibl2=	M3PDWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
NCI-SNU-1	M{fvT2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnrWTWM2OCB;IECuNFE3KG6P	Mk[4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
PSN1	M1ezSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MkToTWM2OCB;IECuNFE3PSCwTR?=	NIXkXno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
HUTU-80	NH\tTHJIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MVnJR\|UxKD1iMD6wNVY3KG6P	NYHZR4hlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
786-0	MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MYnJR\|UxKD1iMD6wNlMhdk1?	Mm[wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
EW-16	M{fWSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NUXlfW1CUUN3MDC9JFAvODJ\|IH7N	NV3oRoNlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
ES1	Mm\HS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M4DTT2lEPTBiPTCwMlAzPjhibl2=	MnO1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
RKO	NVX3SpR1T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NILGNW1KSzVyIE2gNE4xOjd6IH7N	MlHuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
ESS-1	M1\pdWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M1XGcGlEPTBiPTCwMlAzQDZibl2=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
SK-UT-1	NVzjRXhZT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MXzJR\|UxKD1iMD6wNlk4KG6P	NYq3NVRuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
LB2241-RCC	NHLpU\|hIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M1XYNWlEPTBiPTCwMlA{OThibl2=	NVmz[pI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
CHL-1	NECyWo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NWPZeoE3UUN3MDC9JFAvODN{NDDuUS=>	M4XkXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
SW1783	NI\GdG9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MlzHTWM2OCB;IECuNFM{PiCwTR?=	NYjpeW5uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
MEL-JUSO	MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M2rY[2lEPTBiPTCwMlA{QTFibl2=	NVjXN3djRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
HT-29	MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NXf4emx4UUN3MDC9JFAvODRzMzDuUS=>	NHewToM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
SNG-M	M2W2fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NFnaSVhKSzVyIE2gNE4xPDJ3IH7N	NVPRXIJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
TE-15	MlPDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M2[0ZWlEPTBiPTCwMlA1PjRibl2=	MlLXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
HOS	MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MUjJR\|UxKD1iMD6wOFghdk1?	M3L3UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
BB65-RCC	NVvnUJhHT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		NF7pUoJKSzVyIE2gNE4xPTF{IH7N	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
HCE-4	M17wR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NVPnOHRCUUN3MDC9JFAvODV{ODDuUS=>	NE\icVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
MHH-ES-1	MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MYfJR\|UxKD1iMD6wOVMyKG6P	NVPWU45RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
RPMI-7951	M{nySWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnviTWM2OCB;IECuNFU1OSCwTR?=	NHnjd4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
IST-SL2	MoLUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		Mn6zTWM2OCB;IECuNFU5PCCwTR?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
CMK	NHnIRpFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NUfsXllOUUN3MDC9JFAvODV6NjDuUS=>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
GR-ST	MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M1jGN2lEPTBiPTCwMlA2QTVibl2=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
NALM-6	NVX0U\|QyT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M3nKcmlEPTBiPTCwMlA3OjJibl2=	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
RPMI-6666	MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MWnJR\|UxKD1iMD6wOlUzKG6P	NUDT[GxNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
LC-2-ad	NWLrVXdNT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MW\JR\|UxKD1iMD6wOlU{KG6P	NGPCbZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
ARH-77	NW\nXVB1T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M1znUWlEPTBiPTCwMlA4OTFibl2=	M2\VT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
IST-MEL1	Mme0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		M1[1SWlEPTBiPTCwMlA4OjZibl2=	NFz5S4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
SW1710	NIDOe5JIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MYDJR\|UxKD1iMD6wO\|UyKG6P	NEfDbXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw5QDhxJ{7TRW5ITVJ:L3G+
DEL	M1u2XWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M2SzT2lEPTBiPTCwMlA5QDdibl2=	NULZZmtURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
AGS	M3fLdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NI\QcoJKSzVyIE2gNE4xQTB{IH7N	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
NCI-H2122	M2HLWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnH6TWM2OCB;IECuNFk1PSCwTR?=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
HSC-4	MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NYTySHh4UUN3MDC9JFAvOTB{MjDuUS=>	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
AM-38	M2Ts[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M1zWNmlEPTBiPTCwMlEzOTVibl2=	MmjlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
769-P	NIrDU2dIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		NXG3[4xoUUN3MDC9JFAvOTJ\|MTDuUS=>	M{DR[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
RT-112	M{XneWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MWLJR\|UxKD1iMD6xNlc{KG6P	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly4PFgwLz6VQV7HSXI9N2F-
MCF7	M{\H[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NH7vfFZKSzVyIE2gNE4yOzV7IH7N	M1zPblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
IGROV-1	MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M1;Y[GlEPTBiPTCwMlE1PSCwTR?=	NXrlXWNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
OCI-AML2	MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MYPJR\|UxKD1iMD6xOFY3KG6P	MoCwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMPFg5Nyd-U1HOS2VTRC:jPh?=
NCI-H1299	M1zZNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		M3XyVmlEPTBiPTCwMlE2PjZibl2=	NU\FXFdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
A431	M1fobWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MUTJR\|UxKD1iMD6xPFMyKG6P	M2L4VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFg5QC9pPmPBUmdGWjxxYU6=
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BB30-HNC	NWDPVlBVT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M2rscWlEPTBiPTCwMlI{OTJibl2=	NYXCOIY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNQDh6Lze+V2FPT0WUPD;hQi=>
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SF268	NFKwdXZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	M1vDVVczKGi{cx?=	NFvrT\|JKSzVyIE2gNE4xOTB\|IN88US=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4OUiwPUc,OTh2Nkm4NFk9N2F-
MDA-MB-231	M2m4dGFvfGmycn;sbYZmemG2aY\lJIF{e2G7		NILZSGxKSzVyIE2gNE4xOTF2IN88US=>	M{LUdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5OEi3OlY{Lz5zN{i4O\|Y3OzxxYU6=
Jurkat	MVLDfZRwfG:6aXPpeJkh[XO\|YYm=	MVeyOEBpenN?	NYjnS5dCVER3MDC9JFAvODF{IN88US=>	NFnCb2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe4OlkyPSd-MkS3PFY6OTV:L3G+
H292	NYfpb3dUT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		M4H0cWlEPTBiPTCwMlAyOyEQvF2=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZyMkS2OEc,OTd4MEK0OlQ9N2F-
L1210	MVjDfZRwfG:6aXPpeJkh[XO\|YYm=	M3fCTVIh\GG7cx?=	MV7JR\|UxKD1iMD6wNVMh\|ryP	NGf6bFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO0NVM2Pid-MkSzOFE{PTZ:L3G+
L1210	NUDxZ5ZiS3m2b4TvfIlkcXS7IHHzd4F6	M4fI[FQ5KGi{cx?=	NGjxcndKSzVyIE2gNE4xOTNizszN	NYqxNIdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O\|E6QThpPkK0OFcyQTl6PD;hQi=>
SW480	NHrYfnhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	M2D3WVczKGi{cx?=	NHi0[JNKSzVyIE2gNE4xOTN4IN88US=>	M1;jRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NE[5PFA6Lz5zOES2PVgxQTxxYU6=
A549	NHPhXmtIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MYHJR\|UxKD1iMD6wNVQh\|ryP	M1\tPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkCyOFY1Lz5zN{[wNlQ3PDxxYU6=
A2780	NULxOYVOT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MVPJR\|UxKD1iMD6wNVUh\|ryP	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZyMkS2OEc,OTd4MEK0OlQ9N2F-
SW1573	NFXlU4lIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		M3TwWWlEPTBiPTCwMlAyPiEQvF2=	M3H0W\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkCyOFY1Lz5zN{[wNlQ3PDxxYU6=
A2780	MVLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?	MYC3NkBpenN?	MVnJR\|UxKD1iMD6wNVY3KM7:TR?=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4OUiwPUc,OTh2Nkm4NFk9N2F-
T24	MmK0R5l1d3SxeHnjbZR6KGG\|c3H5	NUXEelFnOjRiaILz	M2HKUWlEPTBiPTCwMlAyPyEQvF2=	NX:wbpJrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O\|Q{OzBpPkK1PFc1OzNyPD;hQi=>
T24	MYjDfZRwfG:6aXPpeJkh[XO\|YYm=	M4fkUFI1KGi{cx?=	MYDJR\|UxKD1iMD6wNVgh\|ryP	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5NEOzNEc,OjV6N{SzN\|A9N2F-
P388D1	NH3sRnBEgXSxdH;4bYNqfHliYYPzZZk>	MXmzJIRigXN?	M1HsfWlEPTBiPTCwMlAyQSEQvF2=	MkLWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MUGwOVQoRjJzN{GxNFU1RC:jPh?=
Capan1	MnPKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?	MWm5OkBpenN?	MmPVTWM2OCB;IECuNFE6KM7:TR?=	MkPiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl\|NU[1N\|IoRjJ7M{W2OVMzRC:jPh?=
SF539	Mnn0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?	MVq3NkBpenN?	NVTDSFM4UUN3MDC9JFAvODF7ODFOwG0>	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR4OUiwPUc,OTh2Nkm4NFk9N2F-
SF539	M4jH[WFvfGmycn;sbYZmemG2aY\lJIF{e2G7	M1jKUlczKGi{cx?=	NETFV25KSzVyIE2gNE4xOiEQvF2=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh5M{e0NEc,OjB6N{O3OFA9N2F-
A549	NFzwU2RCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	Mm\XO\|IhcHK\|	M3OxfmlEPTBiPTCwMlAzKM7:TR?=	NGrnRmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki2NVQ6QSd-MkK4OlE1QTl:L3G+
CCRF-CEM	MmrRR5l1d3SxeHnjbZR6KGG\|c3H5	MnzzO\|IhcHK\|	MYnJR\|UxKD1iMD6wNkDPxE1?	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ{MUe5NEc,Ojh{MkG3PVA9N2F-
MRC5	MUTDfZRwfG:6aXPpeJkh[XO\|YYm=	MlX2NlQhcHK\|	MnHnTWM2OCB;IECuNFIyPiEQvF2=	NXfr[mVuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4O\|Q{OzBpPkK1PFc1OzNyPD;hQi=>
CEM-DNR-bulk	NYmwcnF{S3m2b4TvfIlkcXS7IHHzd4F6	NYTvcmRYOyCmYYnz	NV\QPIpLUUN3MDC9JFAvODJ{IN88US=>	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzMUC1OEc,OjF5MUGwOVQ9N2F-
Jurkat	M17BOGN6fG:2b4jpZ4l1gSCjc4PhfS=>	NWq1ZVRbPzJiaILz	NYXSbI53TUN3MDC9JFAvODJ\|IN88US=>	M1jOclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEOyN\|MyLz5{N{CzNlM{OTxxYU6=
HeLa	M{LwOGN6fG:2b4jpZ4l1gSCjc4PhfS=>	MUWyOEBpenN?	M4DTPWxFPTBiPTCwMlAzOyEQvF2=	NWfPbpBvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS3PFY6OTVpPkK0O\|g3QTF3PD;hQi=>
MDA-MB-231	NXmwdpVPSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	NWrjTYliPDhiaILz	Ml:yTWM2OCB;IECuNFI2KM7:TR?=	NYXlNIZ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzOVA6OjNpPkK1N\|UxQTJ\|PD;hQi=>
U373-MAGI	NY\Q[\|RWSW62aY\pdoFtKGG\|c3H5	M1LKV\|IhcHK\|	NWPIeJlOTUN3MDC9JFAvODJ5NTFOwG0>	M1vKOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUKwNFg5Lz5{NEGyNFA5QDxxYU6=
A549	NY\QbYNkS3m2b4TvfIlkcXS7IHHzd4F6	NHK3WoozPCCqcoO=	M4DEO2lEPTBiPTCwMlAzQSEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh5NEOzNEc,OjV6N{SzN\|A9N2F-
HT29	NYj1dWFtSW62aYT1cY9zKGG\|c3H5	MWq0PEBpenN?	NXjWPHdiT0l3MDC9JFAvODNizszN	Mm\4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh3OEiyPFEoRjF6NUi4NlgyRC:jPh?=
Jurkat	NF\HfmRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	MkHzO\|IhcHK\|	M3r6bmlEPTBiPTCwMlA{KM7:TR?=	NEHXdVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N\|c1OCd-MkC4O\|M4PDB:L3G+
HCT116	NYKxdW9MS3m2b4TvfIlkcXS7IHHzd4F6	MXe3NkBpenN?	MonETWM2OCB;IECuNFMh\|ryP	NG[yVGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKyNVc6OCd-MkiyNlE4QTB:L3G+
MDA-MB-231	MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?	NGr5ZWc4OiCqcoO=	M3TiVmlEPTBiPTCwMlA{KM7:TR?=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTJ3M{O0NEc,Ojl{NUOzOFA9N2F-
HCT116	MkP2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?	MlSxO\|IhcHK\|	NWm2eoh{UUN3MDC9JFAvODNizszN	M4HFb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MkWzN\|QxLz5{OUK1N\|M1ODxxYU6=
A2780	M4f6e2FvfGmycn;sbYZmemG2aY\lJIF{e2G7	M{XxRVczKGi{cx?=	NW\VZ5RoUUN3MDC9JFAvODN3IN88US=>	NIe1fYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N\|c1OCd-MkC4O\|M4PDB:L3G+
DU-145	M1zGVmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MWTJR\|UxKD1iMD6wN\|U3KM7:TR?=	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTd{OEG5NUc,OTF5MkixPVE9N2F-
MIAPaCa2	NGjUbm5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=	Mlz5OFghcHK\|	MnO0S2k2OCB;IECuNFM2QDNizszN	NFe0SpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C5OFk6Oid-MkOwPVQ6QTJ:L3G+
MDA-MB-231	MnPURY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?	NUmzRYpOPDhiaILz	MmXRTWM2OCB;IECuNFM3PCEQvF2=	NVriVHdrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3PVU4PjdpPkK5O\|k2PzZ5PD;hQi=>
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Jurkat	NV24R2M2SW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	NFiwdXU4OiCqcoO=	MnnvTWM2OCB;IECuNFQ2OyEQvF2=	MnG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2Nkm4NFkoRjF6NE[5PFA6RC:jPh?=
HeLa	NYe3PWFCS3m2b4TvfIlkcXS7IHHzd4F6	NGjwdFE4OiCqcoO=	MoraTWM2OCB;IECuNFUh\|ryP	NFX2S3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm0OFEyQSd-MkK5OFQyOTl:L3G+
K562	NUPMcm8xS3m2b4TvfIlkcXS7IHHzd4F6	M1\uRVQ5KGi{cx?=	MnezTWM2OCB;IECuNFUh\|ryP	M4W2PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkOxN\|U6Lz5{NE[zNVM2QTxxYU6=
A549	MX3DfZRwfG:6aXPpeJkh[XO\|YYm=	MoDGO\|IhcHK\|	NYX1fFlCUUN3MDC9JFAvODVizszN	M3;4OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkKxO\|kxLz5{OEKyNVc6ODxxYU6=
K562-TAX	M3rPc2N6fG:2b4jpZ4l1gSCjc4PhfS=>	MoLHO\|IhcHK\|	MXnJR\|UxKD1iMD6wOUDPxE1?	NH3lXVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEKyNVc6OCd-MkiyNlE4QTB:L3G+
COLO205	M2LM[2FvfGmycn;sbYZmemG2aY\lJIF{e2G7	NH3TeYo4OiCqcoO=	MnXwTWM2OCB;IECuNFUyPCEQvF2=	M3ToRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NE[5PFA6Lz5zOES2PVgxQTxxYU6=
MCF7	M{nYOWN6fG:2b4jpZ4l1gSCjc4PhfS=>	NIXwOJg4OiCqcoO=	NWG2UIlHUUN3MDC9JFAvODZizszN	M3jKelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUS0NVE6Lz5{Mkm0OFEyQTxxYU6=
MIAPaCa2	NV;XXmFFS3m2b4TvfIlkcXS7IHHzd4F6	NITpSZg4OiCqcoO=	M4DRZmlEPTBiPTCwMlA3KM7:TR?=	NYf1bWR[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5OFQyOTlpPkKyPVQ1OTF7PD;hQi=>
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CEM	MUfDfZRwfG:6aXPpeJkh[XO\|YYm=	M4HZO\|Mh\GG7cx?=	M1PKOmlEPTBiPTCwMlA3QSEQvF2=	NX7xZZlFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOFE{PTZpPkK0N\|QyOzV4PD;hQi=>
HPAC	MUXDfZRwfG:6aXPpeJkh[XO\|YYm=	MlLBN{Bl[Xm\|	M2jFU2lEPTBiPTCwMlA4OyEQvF2=	NEDkOHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUexNVA2PCd-MkG3NVExPTR:L3G+
MCF7	M2iydWFvfGmycn;sbYZmemG2aY\lJIF{e2G7	M373U\|czKGi{cx?=	NWXSN4NSUUN3MDC9JFAvODhizszN	M2L6TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOEezO\|QxLz5{MEi3N\|c1ODxxYU6=
MCF7	M4nWdmFvfGmycn;sbYZmemG2aY\lJIF{e2G7	NETWe5g4OiCqcoO=	MkDvTWM2OCB;IECuNFgxOyEQvF2=	NEHMd3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES2PVgxQSd-MUi0Olk5ODl:L3G+
CEM	M1[wPWN6fG:2b4jpZ4l1gSCjc4PhfS=>	NGnIU4o4OiCqcoO=	MmGyTWM2OCB;IECuNFg3KM7:TR?=	MoTxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2N{G5PVgoRjJ2NEexPVk5RC:jPh?=
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MIAPaCa2	NVnqWJNOSW62aYDyc4xq\mW{YYTpeoUh[XO\|YYm=	M3:2TlcxKGi{cx?=	NYfqUo54UUN3MDC9JFAvOTJizszN	MnP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2N{GxNVkoRjJ7NEexNVE6RC:jPh?=
CEM	MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MnvXTWM2OCB;IECuNVMh\|ryP	NHr4S249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wNlQ3PCd-MUe2NFI1PjR:L3G+
MCF7	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=	M4[wS\|Mh\GG7cx?=	MVnJR\|UxKD1iMD6xOFkh\|ryP	NH3WO449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUexNVA2PCd-MkG3NVExPTR:L3G+
MCF7	M2TNVGN6fG:2b4jpZ4l1gSCjc4PhfS=>	MUC3NkBpenN?	NIXHR5JKSzVyIE2gNE4yPSEQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB{NUi3OUc,OjZyMkW4O\|U9N2F-
CaCo2	NG\FcYJCdnSrdIXtc5Ih[XO\|YYm=	NGO3T3A1QCCqcoO=	MXLHTVUxKD1iMD6xPEDPxE1?	M{TWXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUi4NlgyLz5zOEW4PFI5OTxxYU6=
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MDA-MB-231	MmrlR5l1d3SxeHnjbZR6KGG\|c3H5	MX[yOEBpenN?	M3e0T2lEPTBiPTCwMlE6KM7:TR?=	NGnsfFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUewN\|I6Pid-MkW3NFMzQTZ:L3G+
H292	Ml;SS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?		MoPMTWM2OCB;IECuNlEh\|ryP	M4rRXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkCyOFY1Lz5zN{[wNlQ3PDxxYU6=
A549	M3;QUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MnThTWM2OCB;IECuNlI2KM7:TR?=	Mk\uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MEK0OlQoRjF5NkCyOFY1RC:jPh?=
NCI-H460	M132bWN6fG:2b4jpZ4l1gSCjc4PhfS=>	NFrjdIk1QCCqcoO=	MUfJR\|UxKD1iMD6yN{DPxE1?	Mn\yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|NEKxOFYoRjJ{M{SyNVQ3RC:jPh?=
MDA-MB-231	M2G4ZmN6fG:2b4jpZ4l1gSCjc4PhfS=>	MonvN{Bl[Xm\|	M4TtVWlEPTBiPTCwMlI1PSEQvF2=	M2W3XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{GxNFU1Lz5{MUexNVA2PDxxYU6=
SW1573	MWfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NGT1[G5KSzVyIE2gNE4zPzVizszN	MljNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MEK0OlQoRjF5NkCyOFY1RC:jPh?=
A2780	MVTDfZRwfG:6aXPpeJkh[XO\|YYm=	MVO3NkBpenN?	NIfyc5VKSzVyIE2gNE4{OSEQvF2=	MlHJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|NkK0O\|QoRjF7M{[yOFc1RC:jPh?=
K562	MojxRY51cXS3bX;yJIF{e2G7	M{Ox[VQ5KGi{cx?=	MYTHTVUxKD1iMD6zNkDPxE1?	M{fZWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NUi4NlgyLz5zOEW4PFI5OTxxYU6=
HCT116	NGPGTW1EgXSxdH;4bYNqfHliYYPzZZk>	M2S5WlQ5KGi{cx?=	NUS0XpBSUUN3MDC9JFAvOzJizszN	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN2MkG0Okc,OjJ\|NEKxOFY9N2F-
CFPAC-1	NHLv[oREgXSxdH;4bYNqfHliYYPzZZk>	MlLRPVYhcHK\|	MVrJR\|UxKD1iMD6zOUDPxE1?	NGOwN2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[zNVM2QSd-MkS2N\|E{PTl:L3G+
PANC1	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=	NXHz[4w3PzJiaILz	MlXBTWM2OCB;IECuOEDPxE1?	NFLxbmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[1OlIxOid-Mkm2OVYzODJ:L3G+
HCT116	MWLDfZRwfG:6aXPpeJkh[XO\|YYm=	MnnoO\|IhcHK\|	NYnjdnN5UUN3MDC9JFAvPDFizszN	Ml\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{MkG3PVAoRjJ6MkKxO\|kxRC:jPh?=
CFPAC-1	MnW1R5l1d3SxeHnjbZR6KGG\|c3H5	NG\rbpk4OiCqcoO=	M1\WemlEPTBiPTCwMlQ4KM7:TR?=	MlqwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4M{GzOVkoRjJ2NkOxN\|U6RC:jPh?=
ACHN	M{PjVmN6fG:2b4jpZ4l1gSCjc4PhfS=>	NEjvdpQ1QCCqcoO=	NV\FdHJXUUN3MDC9JFAvPDhizszN	MoOyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ\|NEKxOFYoRjJ{M{SyNVQ3RC:jPh?=
HCT116-E6	NFeweWRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	NXnMeHg3PzJiaILz	MUTJR\|UxKD1iMD61JO69VQ>?	Mo\qQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6N{O3OFAoRjJyOEezO\|QxRC:jPh?=
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LNCAP	MXjDfZRwfG:6aXPpeJkh[XO\|YYm=	M4ThVVMh\GG7cx?=	MkH1TWM2OCB;IECuOVEzKM7:TR?=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzMUC1OEc,OjF5MUGwOVQ9N2F-
Calu1	MULDfZRwfG:6aXPpeJkh[XO\|YYm=	NVT6bIpMPDhiaILz	NHv1[GtKSzVyIE2gNE42OiEQvF2=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN2MkG0Okc,OjJ\|NEKxOFY9N2F-
HT-29	MWLDfZRwfG:6aXPpeJkh[XO\|YYm=	M3vaZ\|czKGi{cx?=	NUH2bYxqUUN3MDC9JFAvPTJizszN	NH6yZZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkCyOVg4PSd-Mk[wNlU5PzV:L3G+
MCF7	M2\VNmN6fG:2b4jpZ4l1gSCjc4PhfS=>	NXztd\|EyPzJiaILz	M2i3T2lEPTBiPTCwMlU4KM7:TR?=	MkDRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyN{W1PVIoRjJ6MEe1OVkzRC:jPh?=
K562	NEnFSJpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	MXm3NkBpenN?	NFnkS2FKSzVyIE2gNE43KM7:TR?=	NF7OXlM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi3N\|c1OCd-MkC4O\|M4PDB:L3G+
MIAPaCa2	NUj4dHQ5S3m2b4TvfIlkcXS7IHHzd4F6	NUP4W5NmOjRiaILz	M2n2N2lEPTBiPTCwMlYh\|ryP	NVryWFdHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NFMzQTZpPkK1O\|A{Ojl4PD;hQi=>
MDA-MB-231	M4nVS2N6fG:2b4jpZ4l1gSCjc4PhfS=>	NGjhcGk4OiCqcoO=	NWX2WmVGUUN3MDC9JFAvPjVizszN	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB{NUi3OUc,OjZyMkW4O\|U9N2F-
BxPC3	MY\DfZRwfG:6aXPpeJkh[XO\|YYm=	MXm3NkBpenN?	MWTJR\|UxKD1iMD62O{DPxE1?	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR5MUm5PEc,OjR2N{G5PVg9N2F-
K562	M3jjSGN6fG:2b4jpZ4l1gSCjc4PhfS=>	NUH5TJVrOyCmYYnz	NYniNmdqUUN3MDC9JFAvPzF6IN88US=>	M2\RcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{GxNFU1Lz5{MUexNVA2PDxxYU6=
K562	NH\PbXJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	MWq3NkBpenN?	M{jXSmlEPTBiPTCwMlc1PTlizszN	M1HTd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NE[5PFA6Lz5zOES2PVgxQTxxYU6=
Bel7402	NXn1[os3S3m2b4TvfIlkcXS7IHHzd4F6	MVm3NkBpenN?	M3XTbGlEPTBiPTCwMlg1KM7:TR?=	NEm3U5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUO2NlQ4PCd-MUmzOlI1PzR:L3G+
HCT116/E6	M4nSTmFvfGmycn;sbYZmemG2aY\lJIF{e2G7	NF3Xdo44OiCqcoO=	M1vGPGlEPTBiPTCwMlg6PjVizszN	M{[1N\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NE[5PFA6Lz5zOES2PVgxQTxxYU6=
HeLa	MnnVR5l1d3SxeHnjbZR6KGG\|c3H5	NF\W[5A6PiCqcoO=	NWPlXmlPUUN3MDC9JFAvQSEQvF2=	MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ\|MUO1PUc,OjR4M{GzOVk9N2F-
CEM	NIPJOZpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MYPJR\|UxKD1iMTFOwG0>	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZyMkS2OEc,OTd4MEK0OlQ9N2F-
HB-1	NEXNTIhCdnSrdnnyZYwh[XO\|YYm=	M3PJdFI1KGi{cx?=	MoWySWM2OCB;IEGg{txO	MlvCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB3OEC1OVQoRjJyNUiwOVU1RC:jPh?=
MIAPaCa2	MXLDfZRwfG:6aXPpeJkh[XO\|YYm=	NXP5UVJwPzJiaILz	NFvlR4hKSzVyIE2gNU4xPCEQvF2=	NVTTO5VvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0O\|E6QThpPkK0OFcyQTl6PD;hQi=>
SK-N-AS	MVfDfZRwfG:6aXPpeJkh[XO\|YYm=	MYmzJIRigXN?	MnnnTWM2OCB;IEGuNUDPxE1?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzMUC1OEc,OjF5MUGwOVQ9N2F-
SW1990	MXTDfZRwfG:6aXPpeJkh[XO\|YYm=	NF\6Z5U4OiCqcoO=	MkK0TWM2OCB;IEGuNkDPxE1?	M2faNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{[yOFc1Lz5zOUO2NlQ4PDxxYU6=
A549	Ml7jR5l1d3SxeHnjbZR6KGG\|c3H5	NXTLTGVzPzJiaILz	MV\JR\|UxKD1iMT60JO69VQ>?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTN4MkS3OEc,OTl\|NkK0O\|Q9N2F-
HepG2	MnP6SpVv[3Srb36gZZN{[Xl?		NIf0bZhMdSB;IEGuOEDPxE1?	NXf5dFN2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexNFE3PzRpPkG3NVAyPjd2PD;hQi=>
BL21(DE3)	M1jkfGZ2dmO2aX;uJIF{e2G7		MlnLT40hRSBzLkSzJO69VQ>?	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ\|MEGzNUc,OjN{M{CxN\|E9N2F-
U87MG	MYHDfZRwfG:6aXPpeJkh[XO\|YYm=	M1[4WlMh\GG7cx?=	NUnLcVFiUUN3MDC9JFEvPDlizszN	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzMUC1OEc,OjF5MUGwOVQ9N2F-
BL21(DE3)	MX3GeY5kfGmxbjDhd5NigQ>?		MVLLcUA:KDFwNUKg{txO	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ\|MEGzNUc,OjN{M{CxN\|E9N2F-
HT-29	MlTYR5l1d3SxeHnjbZR6KGG\|c3H5	M4HSdlMh\GG7cx?=	NH7qSmpKSzVyIE2gNU42OyEQvF2=	M33IcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{GxNFU1Lz5{MUexNVA2PDxxYU6=
SW1990	NV\UTI5oS3m2b4TvfIlkcXS7IHHzd4F6		MXLJR\|UxKD1iMT62JO69VQ>?	NIXi[oY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEG5OVQ3Pid-MkSxPVU1PjZ:L3G+
Capan2	MWnDfZRwfG:6aXPpeJkh[XO\|YYm=	M3THWFczKGi{cx?=	M4XEUGlEPTBiPTCxMlch\|ryP	M1HpS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{[yOFc1Lz5zOUO2NlQ4PDxxYU6=
SW480	M3ToPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7	MnLaO\|IhcHK\|	NH;TTmJKSzVyIE2gNU44KM7:TR?=	NXLOcmFMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O\|M4PDBpPkKwPFc{PzRyPD;hQi=>
PANC1	NEHEe4REgXSxdH;4bYNqfHliYYPzZZk>	NHrxb2Y4OiCqcoO=	Mn64TWM2OCB;IEGuO{DPxE1?	M{K0O\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkW2NlAzLz5{OU[1OlIxOjxxYU6=
HCT8	MX3DfZRwfG:6aXPpeJkh[XO\|YYm=	NHXRbJY4OiCqcoO=	M1GwdGlEPTBiPTCxMlc1KM7:TR?=	MmHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|NkK0O\|QoRjF7M{[yOFc1RC:jPh?=
BL21(DE3)	MXvGeY5kfGmxbjDhd5NigQ>?		MYHLcUA:KDFwN{Wg{txO	NYTRb41CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyN\|AyOzFpPkKzNlMxOTNzPD;hQi=>
HT-29	NXLUcYFNS3m2b4TvfIlkcXS7IHHzd4F6	M3;DVlQ5KGi{cx?=	MVzJR\|UxKD1iMT65OUDPxE1?	NHTxPIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2PFgzPCd-MkO5Olg5OjR:L3G+
MIAPaCa2	MWTDfZRwfG:6aXPpeJkh[XO\|YYm=	NVq0eZBKPSCmYYnz	M2XwN2VEPTBiPTCyJO69VQ>?	M3naUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OE[3OVkxLz5{NEi2O\|U6ODxxYU6=
BL21(DE3)	NY\0N3BsTnWwY4Tpc44h[XO\|YYm=	MWqxJI1qdg>?	NHLLN4FMdSB;IEKuNVUh\|ryP	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ\|MEGzNUc,OjN{M{CxN\|E9N2F-
SW1990	NY\ocpI2S3m2b4TvfIlkcXS7IHHzd4F6		M2fMUGlEPTBiPTCyMlIh\|ryP	NV7WU5pIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWxNFU4OjJpPkK1NVA2PzJ{PD;hQi=>
SW1990	MUnDfZRwfG:6aXPpeJkh[XO\|YYm=	MVS0PEBpenN?	NIHCN3RKSzVyIE2gNk4{KM7:TR?=	NEm1ZVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m2Olk2OCd-Mke5OlY6PTB:L3G+
NCI-H146	MlG0R5l1d3SxeHnjbZR6KGG\|c3H5	NYL1cohJOyCmYYnz	NYPweYhiUUN3MDC9JFIvPzhizszN	M4X3ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{GxNFU1Lz5{MUexNVA2PDxxYU6=
BxPC3	M336UmN6fG:2b4jpZ4l1gSCjc4PhfS=>	NVzIc5V2PzJiaILz	MVnJR\|UxKD1iMj65JO69VQ>?	MlrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl\|NkK0O\|QoRjF7M{[yOFc1RC:jPh?=
p53 deficient COLO205	Mn;aRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?	MlrKO\|IhcHK\|	NHfofFlKSzVyIE2gN{DPxE1?	NVy4O2Y2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4O\|M4PDBpPkKwPFc{PzRyPD;hQi=>
MiaPaCa	MlLqR5l1d3SxeHnjbZR6KGG\|c3H5	MVu2JIRigXN?	MlLtTWM2OCB;IEOg{txO	M1PpZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|M{[wNVA1Lz5{M{O2NFExPDxxYU6=
COLO205	NEHw[W1EgXSxdH;4bYNqfHliYYPzZZk>	NH\SepU1QCCqcoO=	MnW2TWM2OCB;IEOuNlQh\|ryP	NEnUNZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2PFgzPCd-MkO5Olg5OjR:L3G+
MCF7	M2T4bGN6fG:2b4jpZ4l1gSCjc4PhfS=>	NIfibWE4OiCqcoO=	NWHBbYtNUUN3MDC9JFMvOjhizszN	M17rN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{[yOFc1Lz5zOUO2NlQ4PDxxYU6=
MIAPaCa2	Mn;2R5l1d3SxeHnjbZR6KGG\|c3H5	NHXhPVA4OiCqcoO=	NUn6NZZiUUN3MDC9JFMvOyEQvF2=	M1XaXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7M{K4OlU3Lz5{OUOyPFY2PjxxYU6=
HeLa	NXTMdYlxS3m2b4TvfIlkcXS7IHHzd4F6	Ml:0NlQhcHK\|	MWXJR\|UxKD1iMz6zJO69VQ>?	M{TRSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{CzNlk3Lz5{NUewN\|I6PjxxYU6=
FTC-133	MljuR5l1d3SxeHnjbZR6KGG\|c3H5	MUOyOEBpenN?	MU\JR\|UxKD1iMz6zOkDPxE1?	M4THWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEO2PVk1Lz5{NESzOlk6PDxxYU6=
BxPC3	NWCxSXJKT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=	M4H2VlQ5KGi{cx?=	NXmxS3BwT0l3MDC9JFMvPjRizszN	M3GzNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUGyPVA5Lz5{MkWxNlkxQDxxYU6=
COLO320DM	NFTBc3hEgXSxdH;4bYNqfHliYYPzZZk>	M3jMVFQ5KGi{cx?=	M3P5ZmlEPTBiPTCzMlkzKM7:TR?=	NHTSXI09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m2PFgzPCd-MkO5Olg5OjR:L3G+
HeLa	NEHMeIFEgXSxdH;4bYNqfHliYYPzZZk>	NFnCbng{KGSjeYO=	MUfJR\|UxKD1iND6xNkDPxE1?	M1zYW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{GxNFU1Lz5{MUexNVA2PDxxYU6=
8305C	MnvLR5l1d3SxeHnjbZR6KGG\|c3H5	M4XkNlI1KGi{cx?=	NWL3blZwUUN3MDC9JFQvPTNizszN	M3L0TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEO2PVk1Lz5{NESzOlk6PDxxYU6=
PANC1	M{LIUGN6fG:2b4jpZ4l1gSCjc4PhfS=>	NVe2PGFYPzJiaILz	MXnJR\|UxKD1iNT62JO69VQ>?	M3:wWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7M{[yOFc1Lz5zOUO2NlQ4PDxxYU6=
PANC1	MojJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?	MnXlO\|IhcHK\|	MknrS2k2OCB;IEWuPEDPxE1?	MmHaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2OUWwPFEoRjJ6NEm1NFgyRC:jPh?=
SK-MEL-2	NVnQW5B4S3m2b4TvfIlkcXS7IHHzd4F6	NGXMdnY{KGSjeYO=	MlLPTWM2OCB;IEeuNVEh\|ryP	MofLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5MUGwOVQoRjJzN{GxNFU1RC:jPh?=
CEM	NEjaSWlEgXSxdH;4bYNqfHliYYPzZZk>	M4LofVMh\GG7cx?=	NWrXWlFSUUN3MDC9JFcvPiEQvF2=	NHTNdFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO0NVM2Pid-MkSzOFE{PTZ:L3G+
SW1573	MYPDfZRwfG:6aXPpeJkh[XO\|YYm=	MYe3NkBpenN?	MljTTWM2OCB;IEiuN{DPxE1?	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzOU[wOEc,OTd2MUm2NFQ9N2F-
BxPC3	NHfscIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=	NHj5SY41QCCqcoO=	MmTHUGM2OCB;IEiuO\|Eh\|ryP	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjVzMkmwPEc,OjJ3MUK5NFg9N2F-
MCF7	MVjDfZRwfG:6aXPpeJkh[XO\|YYm=	MX:3NkBpenN?	Mn;aTWM2OCB;IEiuPUDPxE1?	NGrPPI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC3OVU6Oid-MkiwO\|U2QTJ:L3G+
BJ	NHTXb21EgXSxdH;4bYNqfHliYYPzZZk>	M3fDXlMh\GG7cx?=	M{DaZ2lEPTBiPTC5Mlg5KM7:TR?=	M4HUWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{GxNFU1Lz5{MUexNVA2PDxxYU6=
HeLa	MY\DfZRwfG:6aXPpeJkh[XO\|YYm=	NF3TV3E4OiCqcoO=	NWm1WWVVUUN3MDC9JFExKM7:TR?=	NInzPWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NE[zNVM2QSd-MkS2N\|E{PTl:L3G+
B16-F10-Luc-G5	MXLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?	M{\1[VI1KGi{cx?=	NXHDTm1zUUN3MDC9JFEyKM7:TR?=	NXj6[49ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkezOFk{OzJpPkK3N\|Q6OzN{PD;hQi=>
HCT15	MYnDfZRwfG:6aXPpeJkh[XO\|YYm=		NEPjb5hKSzVyIE2gNVEvQCEQvF2=	MlrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThzOE[2NFQoRjF6MUi2OlA1RC:jPh?=
A549	MV\DfZRwfG:6aXPpeJkh[XO\|YYm=	M1vUXVczKGi{cx?=	MY\JR\|UxKD1iMUOuNUDPxE1?	NVPuOHB5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0NVk3ODRpPkG3OFE6PjB2PD;hQi=>
HCT116	NU\F[4xHS3m2b4TvfIlkcXS7IHHzd4F6		NXTTZ\|ZPUUN3MDC9JFE1NjNizszN	M1WxU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MUi2OlA1Lz5zOEG4OlYxPDxxYU6=
MiaPaCa	NXzB[ZNIS3m2b4TvfIlkcXS7IHHzd4F6	NV3z[4N2PzJiaILz	NF7aN2pKSzVyIE2gNVcvOSEQvF2=	NU\pOldyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PFk3OjZpPkKzOFg6PjJ4PD;hQi=>
AG6000	MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NEXjboNKSzVyIE2gNlAh\|ryP	NF7OZmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wNlQ3PCd-MUe2NFI1PjR:L3G+
AG6000	MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NHzqTJJKSzVyIE2gNlAh\|ryP	MonSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MEK0OlQoRjF5NkCyOFY1RC:jPh?=
BxPC3	M4\6bGFvfGmycn;sbYZmemG2aY\lJIF{e2G7	MYi3NkBpenN?	MoD0TWM2OCB;IEKwMlIh\|ryP	NFXqWYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW3OlY{Oyd-Mki1O\|Y3OzN:L3G+
CV1	NH3rPWVEgXSxdH;4bYNqfHliYYPzZZk>	NWfiSINQPzJiaILz	NXTkdYNFUUN3MDC9JFIyNjlizszN	NGPwUJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S4PVYzPid-MkO0PFk3OjZ:L3G+
AsPC1	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?	M2jjblczKGi{cx?=	M2PET2lEPTBiPTCyOk45KM7:TR?=	NFnzVG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEW3OlY{Oyd-Mki1O\|Y3OzN:L3G+
PANC1	NIjT[4dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=	MWK3NkBpenN?	NVTOWlZuUUN3MDC9JFMxNjRizszN	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDV5Nk[zN{c,Ojh3N{[2N\|M9N2F-
MIAPaCa2	M4jYOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7	NHn5[JM1QCCqcoO=	MV\HTVUxKD1iM{WuPFMh\|ryP	NIT5cI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWxNlkxQCd-MkK1NVI6ODh:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-JNK / JNK / p-ATF2 / p-c-Jun; PubMed: 16307741 FEBS Lett Time-dependent activation of the JNK signaling pathway by gemcitabine treatment. H1299 and H1299/GR cells were treated with 100 nM gemcitabine for the indicated time periods. Cell lysates were then subjected to western blotting using total JNK and phospho-specific antibodies to JNK, c-Jun, and ATF2. Maximal phosphorylation of those molecules is observed in H1299 cells treated with gemcitabine for 48 h. caspase-3 / caspase-8 / caspase-9; PubMed: 16307741 FEBS Lett H1299 and H1299/GR cells were treated with 100 nM gemcitabine for the indicated time periods, and proteins in whole-cell lysates were analyzed by immunoblotting with anti-caspase-3, caspase-8, and caspase-9 antibodies. The arrowheads represent cleavage proteins. β-actin was used as a loading control. pS-ERα / ERα / pERK / ERK; PubMed: 27384485 Oncotarget MCF-7 and MDA-MB-231 cells were treated by gemcitabine with different concentrations (MCF-7: 0, 2, 4, 8 μg/ml; MDA-MB-231: 0, 0.5, 1, 2 μg/ml), and the phosphorylation of ERα (ser167), ERK (Thr202/Tyr204) and expression of LC3-I and LC3-II were detected. LC3-I / LC3-II; PubMed: 27384485 Oncotarget A, E. The levels of LC3-I and LC3-II detected by Western blotting were quantified by densitometry using Image J software. The ratio of LC3-II to LC3-I was evaluated after treated with gemcitabine (MCF-7: 4 μg/ml; MDA-MB-231: 1 μg/ml) for 0 h (control), 12, 24 and 48 h. B, F. The ratio of LC3-II to actin was assayed after treated with gemcitabine, chloroquine (CQ) (MCF-7: 2.5 μM; MDA-MB-231: 5 μM), and gemcitabine plus CQ (added before gemcitabine treatment for 1 h) for indicated time (MCF-7: 48 h; MDA-MB-231: 24 h). p70S6K1 / p-S6 / HIF-1α; PubMed: 27765914 Oncotarget Cells were treated with different doses of gemcitabine (0, 1.5 and 2.5 μM), the expression levels of p70S6K1, p-S6 and HIF-1α were determined by Western blotting. GAPDH is used as an internal control.	16307741 27384485 27765914
Immunofluorescence	BMI1; PubMed: 27177084 Oncotarget Gemcitabine enhanced nuclear accumulation of Bmi1 by immunofluorescence staining.	27177084
Growth inhibition assay	Cell viability ; PubMed: 27765914 Oncotarget A and B. Pancreatic adenocarcinoma cells Bxpc-3 (A) and Panc-1 (B) were treated with gemcitabine (GEM) for 48 h at different doses. The cell viability was analyzed by CCK-8 assay, and normalized to cells without gemcitabine treatment.	27765914

In vivo

Intratumoral NF-κB activity is significantly elevated (1.3- to 1.8-fold) in the Gemcitabine-treated mice compared to the PBS-treated mice, suggesting that Gemcitabine also induces NF-κB activation. ^[2]

Protocol

Cell Research:^[2]

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Cell lines: BxPC-3, MIA PaCa-2, and PANC-1 cells
Concentrations: 0.2 μM
Incubation Time: 24 hours or 48 hours
Method: BxPC-3, MIA PaCa-2, and PANC-1 cells are seeded in a 96-well plate. After 24 hours, cells are treated with vehicle, DMAPT and/or Gemcitabine for an additional 24 hours or 48 hours. Apoptosis is quantified using the Cell Death Detection ELISA to detect the amount of cytoplasmic histone-associated DNA fragments and expressed relative to vehicle-treated cells.
(Only for Reference)

Animal Research:^[2]

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Animal Models: Athymic nude mice with MIA PaCa-2 cells
Dosages: 50 mg/kg or 100 mg/kg
Administration: Administered via i.p.
(Only for Reference)

References

Solubility (25°C)

In vitro	Water	19 mg/mL (63.4 mM)
	DMSO	Insoluble
	Ethanol	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): Saline For best results, use promptly after mixing.	19mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Gemcitabine (LY-188011) HCl SDF

Molecular Weight	299.66
Formula	C₉H₁₁F₂N₃O₄.HCI
CAS No.	122111-03-9
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	NSC 613327
Smiles	C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04871321	Recruiting	Drug: nab-paclitaxel plus gemcitabine-cisplatin	Biliary Tract Cancer\|Cholangiocarcinoma\|Gallbladder Cancer	CHA University\|Dong-A Pharmaceutical	July 1 2021	--
NCT04983407	Recruiting	Drug: AVB-S6-500\|Drug: Nab paclitaxel\|Drug: Gemcitabine	Pancreatic Adenocarcinoma	Aravive Inc.	July 28 2021	Phase 1\|Phase 2
NCT04896320	Not yet recruiting	Drug: Tucatinib	Breast Cancer Stage IV	Providence Health & Services\|Seagen Inc.	July 2021	Phase 1\|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
What’s the difference between S1714 and S1149 and which one is better?
Answer:
They have the same biological activities. The free base(S1714) dissolves better in DMSO, and the hydrochloride (S1149) dissolves better in water.

DNA/RNA Synthesis Signaling Pathway Map

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Gemcitabine (LY-188011) HCl