Catalog No.S1149 Synonyms: LY188011
Molecular Weight(MW): 299.66
Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
Cited by 25 Publications
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Choose Selective DNA/RNA Synthesis Inhibitors
|Description||Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.|
|Features||Gemcitabine has been used to treat pancreatic cancer and has demonstrated effective anti-tumor activity.|
Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Treatment of BxPC-3 cells with low dose Gemcitabine for 48 hours results in a dose-dependent increase in NF-κB binding. In contrast, NF-κB DNA binding is decreased in BxPC-3 cells treated with the higher Gemcitabine doses for 48 h; however, 24-h treatment with these higher doses increases NF-κB binding in BxPC-3 cells 
|In vivo||Intratumoral NF-κB activity is significantly elevated (1.3- to 1.8-fold) in the Gemcitabine-treated mice compared to the PBS-treated mice, suggesting that Gemcitabine also induces NF-κB activation. |
|In vitro||Water||19 mg/mL (63.4 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04051047||Not yet recruiting||Drug: Gemcitabine|Procedure: Tumor biopsy and blood draw||Glial Tumor of Brain|Diffuse Intrinsic Pontine Glioma|Glioma||University of Michigan Rogel Cancer Center|University of Colorado Denver||November 30 2019||Early Phase 1|
|NCT03669601||Not yet recruiting||Drug: AZD6738|Drug: Gemcitabine||Cancer||CCTU- Cancer Theme|AstraZeneca|Cambridge University Hospitals NHS Foundation Trust||September 30 2019||Phase 1|
|NCT04046887||Not yet recruiting||Drug: Lonsurf|Drug: Gemcitabine|Drug: Nab-Paclitaxel||Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma||Patrick Joseph Loehrer Sr.|Indiana University|Taiho Oncology Inc.||August 2019||Phase 1|
|NCT03865563||Not yet recruiting||Drug: Retrograde venous infusion of gemcitabine/lipiodol||Pancreatic Adenocarcinoma||Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||July 2019||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
What’s the difference between S1714 and S1149 and which one is better?
They have the same biological activities. The free base(S1714) dissolves better in DMSO, and the hydrochloride (S1149) dissolves better in water.