Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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3 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Western blot analysis shows pERK levels after 8 hours treatment with forskolin. AC activation with 10 μmol/L forskolin (F).

    Mol Cancer Res, 2017, 15(12):1792-1802. Forskolin purchased from Selleck.

  • Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MnvsSpVv[3Srb36gRZN{[Xl? MWCxNEDPxE1? NEj6SG43KGh? M{fwcIlv[3KnYYPld{BxcG:|cHjvdplt[XSrb36gc4Yhd3[ncnX4dJJme3OnZDDLUGhNOyCjdDDTOFM{ MnPGNlY1OzV2OUi=
Mo-DCs MkL3SpVv[3Srb36gRZN{[Xl? MVS1NEDPxE1? M{\1dVI16oDLaB?= M1PNNpBzd22xdHXzJGlNNTJ|IIDyc4R2[3Srb36gbY4hfGinIIP1dIVzdmG2YX70JI9nKHq7bX;zZY4he3SrbYXsZZRm\CCPbz3ER5PDqA>? NILmbWYzPjRzMkm0PC=>
RBMECs  NWT3[4s2TnWwY4Tpc44hSXO|YYm= M1\qXVXDqM7:TR?= MojBNeKhcA>? M4C3dYJtd2OtczD0bIUhWmGlMTDpcoFkfGm4YYTpc44hcW6mdXPl[EBjgSCHTVHQMWlK NGq4eJUzPjN3OECzPS=>
INA-6 MULD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NWTucGd3OC1zMECg{txO M3zrSFcz6oDLaB?= M{j0XYlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 MnnaNlY{ODZ4MkS=
OPM-2 MmDvR4VtdCCYaXHibYxqfHliQYPzZZk> M4X0NFAuOTByIN88US=> NIrm[5g4OuLCiXi= M2\FSolv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 NHjreZUzPjNyNk[yOC=>
U266 MVLD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGTvU3gxNTFyMDFOwG0> MVO3NwKBkWh? NWTRXYpocW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> NYnHU|U4OjZ|ME[2NlQ>
H929 M{[ybWNmdGxiVnnhZoltcXS7IFHzd4F6 NFu5em8xNTFyMDFOwG0> NVzFV2luPzMkgJno MUDpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= NY\Mc4ZwOjZ|ME[2NlQ>
RPMI 8226 MYXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NX3HfI5uOC1zMECg{txO Mo[yO|LjiImq MkXUbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= Ml3jNlY{ODZ4MkS=
MDCK  NEDIS|BHfW6ldHnvckBCe3OjeR?= M2HqS|ExKML3TR?= M{npS|I1KGh? NHTYTXRFVVOR MluxeZBz\We3bHH0[ZMhfGinIHX4dJJme3Orb36gc4YhXEeILd8yNUBidmRiQ2THSuKh MmXTNlYzODJ|NUK=
MDCK  MUPGeY5kfGmxbjDBd5NigQ>? NUfTXI17OTBiwsXN NYTncmFLOjRiaB?= MonOSG1UVw>? NHzIPHZqdmirYnn0d{B1cGViaX7jdoVie2WmIHX4dJJme3Orb36gc4YhTk5iY3H1d4VlKGK7IGTHSk3PujF? NV7ZN5I{OjZ{MEKzOVI>
Spinal cords  M1q3UGZ2dmO2aX;uJGF{e2G7 MoLTNeKh|ryP M2GyNFMxKG2rbh?= NGTBTGd{fGmvdXzheIV{KGODTWCgcIV3\Wy| M{XqPFI3OTJ4OUK2
BeWo  NUnJOIp3TnWwY4Tpc44hSXO|YYm= MYCyOgKBkc7:TR?= MXGyOE81QC95MjDo MnHtcIVi\HNidH:gZY4hcW6lcnXhd4UhcW5idHjlJIV5eHKnc4Ppc44hd2Zib4To[ZIh\nW|aX;uJI1iemuncoO= NGHDfYYzPjB3M{W0PS=>
bovine oocytes M2DhO2Z2dmO2aX;uJGF{e2G7 Ml3kNVAxyqEQvF2= M3LhR|EzyqCq NVnv[GFocW6qaXLpeJMhfGinIHXm[oVkfCCxZjDOVHBCKGGwZD;vdkBPWFCFIITvJJN1cW23bHH0[UBz\XO3bYD0bY9vKG:oIH3lbY9{cXN? MV:yOlA2OTZzMR?=
Caco-2  M4m5ZmZ2dmO2aX;uJGF{e2G7 M4HSPFAvOS9zL{GwJO69VQ>? NFjyT2gzOMLibXnu MUTpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7jdoVie2ViaX6gbY51emGlZXzseYxieiClQV3QJIxmfmWucx?= NFXGZXIzPjB2OUGwNi=>
Caco-2  M1qxZWZ2dmO2aX;uJGF{e2G7 NWLkNJhxOC5zL{GvNVAh|ryP M2XjdlI1KGh? Mo\kbY5kemWjc3XzJG1TWDJicILveIVqdiCuZY\lcC=> M2foNFI3ODR7MUCy
AML-12  M1S4U2Z2dmO2aX;uJGF{e2G7 NYDscnlWOjBizszN NH3ENFE{KGh? NFLNbJF2eHKnZ4XsZZRmeyC2aHWgdIhwe3Cqb4L5cIF1cW:wIHzleoVteyCjdDDUbJIuPDFzIHHu[EBU\XJvNEmz NW\FSXpzOjZyNEi5PFU>
AML-12  MmDsSpVv[3Srb36gRZN{[Xl? NF;XZXEzOCEQvF2= M1TUSFEuQCCq NX3uWIx[cW6lcnXhd4V{KGeudXPvd4UheHKxZIXjeIlwdg>? M1\pOlI3ODR6OUi1
AML-12  Mm[xSpVv[3Srb36gRZN{[Xl? NVXQdldiOjBizszN M4HDPVMhcA>? NVP2dGF4fXBvcnXneYxifGW|wrDQ[4My[S{EoGDldINsNCCjbnVCpGc3eGQEoH3SUmEhdGW4ZXzz NHzFNZMzPjB2OEm4OS=>
AML-12  NETlSJBHfW6ldHnvckBCe3OjeR?= NVqyRmJpOjBizszN M2Dm[|MhcA>? M36wSIlv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKG:oIFPSWGMzyqB? NFv3WHYzPjB2OEm4OS=>
RBMECs NYPaeGNGTnWwY4Tpc44hSXO|YYm= NYHhWIFJPcLizszN Mn;FNUBp NWWxXJJycW6qaXLpeJMhTU2DUD3JTU1qdmS3Y3XkJIlv[WO2aY\heIlwdiCxZjDSZZAyyqB? NFPoNZEzPjB2NE[2Ny=>
EndoC-βH1 NIjQXHNHfW6ldHnvckBCe3OjeR?= NGe5[5E2yqEQvF2= MXexJIg> M{T6S5BwfGWwdHnheIV{KGeudXPvd4UucW6mdXPl[EBqdnO3bHnuJJNm[3KndHnvckBqdiC2aHWgdJJme2WwY3Wgc4Yh\2y3Y3;z[S=> MYCyOlAzQDV4Mh?=
EndoC-βH1 M{HFUWZ2dmO2aX;uJGF{e2G7 NI\SPYg2yqEQvF2= NGjySmMyKGh? M{HjT4xm[WS|IITvJIEhe3S{b37nJINCVVBiaX7jdoVie2V? M1fYV|I3ODJ6NU[y
SH-SY5Y MYHGeY5kfGmxbjDBd5NigQ>? MnrnN|Ah|ryP Ml\hN|AhdWmw NVHSXmdLTE2VTx?= M4DSdpNq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBi[3SrdnH0bY9vKG:oIGDLRS=> MmHmNlYxOjVzM{e=
PC-3 MX3GeY5kfGmxbjDBd5NigQ>? MX[0NEDDvU1? M4jke|IhcA>? NFHRNINFVVOR M1Xy[Ixm[WS|IITvJHBROkFiYXP0bZZifGmxbh?= MVyyOlAzOzh|Nh?=
PC-3 M3PHVmNmdGxiVnnhZoltcXS7IFHzd4F6 M2fDVFQxKML3TR?= NULSNoZSOjRxNEivO|IhcA>? MVTEUXNQ MUnk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHlidHnt[UBl\XCnbnTlcpRtgQ>? NGTSRZUzPjB{M{izOi=>
SCG M{G3cGZ2dmO2aX;uJGF{e2G7 MYOyNEDPxE4EoB?= MVnEUXNQ MUXy[ZZmenOrYnz5JJN2eHC{ZYPz[ZMhUUuYIIfpeIgh[SCLQ{WwJI9nKDJ2LkSg{txO MnPTNlU6PjJzM{K=
HEK-293 MYrGeY5kfGmxbjDBd5NigQ>? NVnxUYd[OzVizszNxsA> MXLEUXNQ M3XDWolv\HWlZYOgZUBkd26|cHnjeY92eyEkgKzpcoFkfGm4YYTpc47jiJ1ib3[geIhmKEu4Mj6xJIN2enKnboS= NIfHcGczPTl4MkGzNi=>
SCG NFnTfnVHfW6ldHnvckBCe3OjeR?= M4HuZlExOCEQvF5CpC=> M1vrfmROW09? NGmwVYZz\WS3Y3XzJJRp\SCneHPpeIFjcWyrdImgc4YhW0OJIH7leZJwdnN? M3;tNlI2QTZ{MUOy
PCCL3 MojoSpVv[3Srb36gRZN{[Xl? MYKxNEDDvU1? NH7SdnMzPCCq M4SySoVvcGGwY3XzJGR2V3h{IIDyc41wfGW{IITyZY5{[3KrcITpc44h[WO2aY\peJnDqOLCix?= NH3LZlkzPTl4MEm1Oi=>
3T3-L1 preadipocytes MlWzSpVv[3Srb36gRZN{[Xl? NULCcXhSOTBizszNxsA> MWqxNkBp MWHpcoR2[2W|IFPSSWIheGixc4Doc5J6dGG2aX;uJIFv\CCFL1XCVO6zKGW6cILld5Nqd25? NH;qcZAzPTl{OEC1PC=>
H295R  Ml3iSpVv[3Srb36gRZN{[Xl? M1TQV|ExyqEQvF2= M{XyZVQ5yqCq M1zEZolv[3KnYYPld{B{fGW{b3nkJI1mfGGkb3zpeIV{KGmwIITo[UBidmS{b3flckwhdWmwZYLhcI8uKGGwZDDncJVkd2OxcoTpZ49q\CCyYYToe4F6ew>? NUTmeXZROjV6Nkm1OVY>
PBMC NFvkWHNHfW6ldHnvckBCe3OjeR?= M{\MO|UxyqEQvF2= MVuyOOKhcMLi NInaNFlqdmirYnn0d{B1cGViaX7jdoVie2WmIIPlZ5JmfGmxbjDv[kBVVkZiaX7keYNm\CCkeTD0bIUhTFCH M3HIelI2QDZ4MEe5
GLUTag  NEnzWG5HfW6ldHnvckBCe3OjeR?= MXuxNQKBkcL3TR?= MX[wM|IwPCCq M1vXdpN1cW23bHH0[ZMhT0ySLUGgd4VkemW2aX;uJINwfHKnYYTl[EB4cXSqIFnCUXg> NYfoOXpiOjV6M{K2N|E>
GLUTag  MWjGeY5kfGmxbjDBd5NigQ>? MYqxNQKBkcL3TR?= NHHEZZg1KGh? NUL6ZZlHcW6lcnXhd4V{KHSqZTDwR3JGSiCuZY\lcJMhf2m2aDD0bIUhUUKPWB?= M4nrcFI2QDN{NkOx
BAECs NHj1XmJHfW6ldHnvckBCe3OjeR?= M{HSV|I2KM7:TR?= NYnidIMzOjRiaB?= NYHOTYJC\W6qYX7j[ZMhfGinIHHjeIl3[XSrb36gc4YhWFCDUt8xJIJ6KDVizszNJJJme3[ncnH0do9tNCCWNFjTMEBweiB2LWDBVC=> NGPBOWgzPTd7OEiyOi=>
PC12 MoPtSpVv[3Srb36gRZN{[Xl? MkC4NlXDqM7:TR?= NYDDRXpOPDhiaB?= NF3qNHZi[3SrdnH0[ZMh[0GPUB?= NVOyTJI2OjV5NkmzNFU>
GH3 NYPBVHRYTnWwY4Tpc44hSXO|YYm= MnLXNeKh|ryP NGjmfGw3NWh? NUG1c2dj[XS2ZX71ZZRmeyC2aHWgZ49zemWuYYTpc44h[mW2d3XlckBRWkxiYX7kJGJu[WxzIHX4dJJme3Orb36= M4DzclI2PzJ5MEG4
GH3 NWHXO2tnTnWwY4Tpc44hSXO|YYm= MnjjNeKh|ryP M1;XPVYucA>? NFXPRVlqdmS3Y3XzJHBTVCCjbnSgRo1idDFuIHL1eEBvd3RiQ3zvZ4stKG2UTlGg[ZhxemW|c3nvci=> NWPu[ZNsOjV5MkewNVg>
BeWo MofxSpVv[3Srb36gRZN{[Xl? Mn3KNVDjiIsQvF5CpC=> NFvsbnc4OiCq NHHubWFFVVOR NImzbmNu\WSrYYTld{BD\VexIHPlcIwh\GmoZnXy[Y51cWG2aX;u MYiyOVcyOzR{NR?=
oocytes M2TBNGZ2dmO2aX;uJGF{e2G7 M{D6ZVUh|ryP MWmyOEBp MXvheJRmdnWjdHXzJJJpNWmwc4XsbY4h[WO2aX;uJI9vKG:xY4n0[UBIXkKGIIPp[45q\mmlYX70cJnDqA>? MXyyOVcxPzh3NB?=
SC M{L1T2Z2dmO2aX;uJGF{e2G7 MWSwMlUh|ryP NGnSXXkzPCCq NILQUYRucW2rY3vzJJRp\SCnZn\lZ5Qhd2ZiY1HNVEBidmGub3fzJI9vKE9zIHHu[EBOSlBiZYjwdoV{e2mxbh?= NFjHXIozPTdyNUi3OC=>
SC NGHndmVHfW6ldHnvckBCe3OjeR?= M2\DUFAvPSEQvF2= MVG3NkBp MXrpcoNz\WG|ZYOgZo91cCCNcn;4MVIxKGGwZDDPNUBmgHC{ZYPzbY9vKGmwIHH4c44uemWuYYTl[EBUS3NiYoX0JI9vdHliS4LvfE0zOMLi M4Xhb|I2PzB3OEe0
UACC-647  MnfDSpVv[3Srb36gRZN{[Xl? MX;EUXNQ MkHycIVi\HNidH:gZUBzcXOnIHnuJINCVVBibHX2[Yx{KCiHQ{WwxsA:yqB{MD6zPeKh|ryPKR?= Mn7aNlU4ODNyMkW=
UACC-647  MYPGeY5kfGmxbjDBd5NigQ>? Mn;YNVDDqM7:TR?= MlTXNVUhdWmw M1HEdGROW09? Mo\EbY5pcWKrdIOgSXJMKHCqb4PwbI9zgWyjdHnvci=> Mlu4NlU4ODNyMkW=
UACC-647  NF\UTmlHfW6ldHnvckBCe3OjeR?= NFiwcVUyOMLizszN NWOxdGVwOTVibXnu NH\ISXJFVVOR NV;XTFREcW6lcnXhd4V{KGWHRkKgdIhwe3Cqb4L5cIF1cW:wIHzleoVte8Li MkTYNlU4ODNyMkW=
SH-SY5Y  M3;UVmZ2dmO2aX;uJGF{e2G7 NUW0VYdYOTEEoN88US=> M2rqWlHDqGkEoB?= MkXEbY5kemWjc3XzJGxWSyCjY4Tpeol1gQ>? MlnyNlU2QTd2M{O=
SH-SY5Y  MV\GeY5kfGmxbjDBd5NigQ>? NGP5bGwyOMLizszN Mn;uNeKhcMLi NH3JdHRqdmO{ZXHz[ZMhSUeFMTDtVm5CKGyndnXs MnT4NlU2QTd2M{O=
hADSCs NHrNR5FHfW6ldHnvckBCe3OjeR?= M3f6blXjiIoEtV2= NFi0SpI{OCCvaX6= NX3md2dicW6lcnXhd4V{KGODTWCgcIV3\Wy| Mn36NlU2QTF7MEi=
HEK293  M3G0U2Z2dmO2aX;uJGF{e2G7 MkH5OgKBkcL3TR?= M2\6bVMxKG2rbh?= M{Da[olv[3KnYYPld{BkSU2SIHzleoVtew>? MWOyOVU6OTlyOB?=
3T3-L1 MWXGeY5kfGmxbjDBd5NigQ>? NHTKV4QzNjVxNTFOwG0> NX\HSllJOjRiaNMg NWfre3dRe2mpbnnmbYNidnSueTDk[YNz\WG|ZYOgRXRIVCCycn;0[YlvKGW6cILld5Nqd25iYYSgZYxtKGSxc3XzJJRme3SnZB?= NILHcGQzPTV7MEW5Oy=>
OCI-Ly1  MmLaSpVv[3Srb36gRZN{[Xl? MkTJOFDDqM7:TR?= M2XEVVHDqGkEoB?= NIHKZXZFVVOR MUXpcoR2[2W|IITo[UBqdmO{ZX3lcpQhd2ZiY1HNVEBkd26lZX70doF1cW:wcx?= NX\V[pZrOjV3N{[yNlA>
OCI-Ly18  MkLRSpVv[3Srb36gRZN{[Xl? MYW0NOKh|ryP NFzHcHMyyqCqwrC= NYL3bpFHTE2VTx?= Mk\3bY5lfWOnczD0bIUhcW6lcnXt[Y51KG:oIHPBUXAh[2:wY3XueJJifGmxboO= NXPmZZQ5OjV3N{[yNlA>
BeWo NFX4SGNHfW6ldHnvckBCe3OjeR?= MUeyNOKhyrWP MWW0POKhcA>? MlGzSG1UVw>? Mm\RbY5kemWjc3XzJJRp\SCmaX\m[ZJmdnSrYYTpc44hd2ZiQnXXc{Bk\Wyucx?= NXuwNXM5OjV3Nk[3OFA>
BeWo NIjZc3dHfW6ldHnvckBCe3OjeR?= NUPPO29JOjEEoNM1US=> MYO0POKhcA>? MlzKSG1UVw>? MmTObY5kemWjc3XzJJRp\SCjZHjld4lwdiCxZjDUTHAuOSCvb37vZ5l1\XN? M4K1XFI2PTZ4N{Sw
LNCaP  MX3GeY5kfGmxbjDBd5NigQ>? M3zWblExyqEQvF2= NVHWZnFsOTJiaNMg MoniSG1UVw>? MmnzbY5lfWOnczDhJIRz[W2jdHnjJIlv[3KnYYPlJI9nKEOURVKxJIFkfGm4aYT5 NHLwU4czPTV2OEC5PS=>
ThGCs  Mm[wSpVv[3Srb36gRZN{[Xl? MXqxNQKBks7:TR?= NUj2WIhzPOLCini= NYrGdFFi[XWpbXXueJMhUEmIMVGgcIV3\Wy|IIToZZQhf2W{ZTDzeIlufWyjdHXkJIJ6KEOxQ3yy M3\DcFI2PDN|MEK3
ThGCs  MV\GeY5kfGmxbjDBd5NigQ>? MVexNQKBks7:TR?= MVu05qCLcA>? MVjpcoNz\WG|ZYOgR49EdDJvaX7keYNm\CCHRF6yxsBo\W6nIHX4dJJme3Orb36= MUOyOVQ{OzB{Nx?=
ThGCs  M2P0V2Z2dmO2aX;uJGF{e2G7 MWOxNQKBks7:TR?= MVGzJIg> NHvFdpZqdmirYnn0d{B1cGViZX\m[YN1KG:oIFiyU|Ihd25iRVTONkBuWk6D NGHFVZMzPTR|M{CyOy=>
RBMECs MXvGeY5kfGmxbjDBd5NigQ>? MVSwMlA2NzBwNT:1JO69VQ>? NHfMVYoxNjJ3IHi= M3TTN4lv[3KnYYPld{BkSU2SIHPvcoNmdnS{YYTpc44> NEDGT5gzPTRzNk[1NS=>
RBMECs NEDOT5hHfW6ldHnvckBCe3OjeR?= M1[5cFXDqM7:TR?= NV\pS29DOSCq NXq3bY1T[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> MYKyOVQyPjZ3MR?=
RBMECs NI\U[mJHfW6ldHnvckBCe3OjeR?= NEXjN482yqEQvF2= MVSxJIg> MonOdJJmfmWwdIOgeIhmKEWPQWCtTWkucW6mdXPl[EBVTUWUII\hcJVmKGSnY4LlZZNm MViyOVQyPjZ3MR?=
RBMECs MoXySpVv[3Srb36gRZN{[Xl? M1j3Z|XDqM7:TR?= NYSzWoRmOSCq MVLwdoV3\W62czD0bIUhcW6lcnXhd4UhcW5iSGLQJIZtfXhiYXPyc5N{KHSqZTDCWGIhcW6mdXPl[EBjgSBiRV3BVE1KUQ>? NH3UUpMzPTRzNk[1NS=>
RBMECs NULBSGNrTnWwY4Tpc44hSXO|YYm= M1LOblXDqM7:TR?= MkLHNUBp M2jpS4lvcGmkaYTzJJRp\SCmZXPy[YF{\WRib3[gZY1wfW62IH;mJHpQNTFiaX6gUWZ{KGmwZIXj[YQh[nliRV3BVE1KUQ>? M4nwcFI2PDF4NkWx
RBMECs NYH5fnpLTnWwY4Tpc44hSXO|YYm= M1jySlXDqM7:TR?= Mo\vNUBp M3\0WZJmfmW{c3XzJJRp\SClaHHu[4V{KGmwIGrPMVEh\Gm|dILpZpV1cW:wIIPl[Y4hf2m2aDDFUWFRNUmLIITy[YF1dWWwdB?= M3zoT|I2PDF4NkWx
RBMECs M4TPSmZ2dmO2aX;uJGF{e2G7 M4rrTlXDqM7:TR?= M1m1flEhcA>? MnXlZoxw[2u|IITo[UBGVUGSLVnJMYlv\HWlZXSgZ4hidmenIHnuJG1NSyCyaH;zdIhwenmuYYTpc44> MnrTNlU1OTZ4NUG=
RBMECs NXjMWWE4TnWwY4Tpc44hSXO|YYm= NXrvbI1ZPcLizszN NGnROGEyKGh? Mk[2Zoxw[2u|IITo[UBi[3SrbjDjfZRwe2unbHX0c44hemWjcoLhcodmdWWwdDDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboVCpC=> NFu4[FMzPTRzNk[1NS=>
Primary bovine chondrocytes MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLiOe69VQ>? NUXqWWRIPDhiaB?= NGLMVG1z\X[ncoPld{B1cGViaX7obYJqfG:{eTDl[oZm[3Rib3[gZ4Vt\WOxeHniJI9vKHC{b3zp[oVz[XSrb36gbY4h\3Kxd4ToJJBt[XSnIHPoc45lem:leYTldy=> NHzB[5AzPTRyNkCxOi=>
EM1  MYrGeY5kfGmxbjDBd5NigQ>? NI[2NJcyPeLCit88US=> MkjBOFghcA>? NX\LSmxlemWmdXPld{B1cGViZYjwdoV{e2mxbjDv[uKhVEmIwrDvduKhWFSJU{NCpIlvyqCFQVzSMUBwesLiRWDBR|Iue2muZX7j[YQhTU1zIHPlcIx{yqB? M3OzS|I2Ozd6Nk[x
BeWo  NI\EWoRHfW6ldHnvckBCe3OjeR?= MYKyNOKhyrWP M3K2[VQ5yqCqwrC= MoTNSG1UV8Li M1WwUYlv[3KnYYPld{B1cGViYnX0ZU1pS0dicnXs[YF{\Q>? M1[1ZVI2OzZ{Mk[w
BeWo  NE\VSVRHfW6ldHnvckBCe3OjeR?= M1v5TlIxyqEEtV2= MV[0POKhcMLi NG\pdGlFVVORwrC= MYPkc5dvemWpdXzheIV{KHSqZTDs[ZZmdCCxZjDUUWVOTjF4 MoWwNlU{PjJ{NkC=
BeWo  MmXVSpVv[3Srb36gRZN{[Xl? MXGyNOKhyrWP MmLQOFjDqGkEoB?= M1TTPGROW00EoB?= MXHkc5dvemWpdXzheIV{KHSqZTDs[ZZmdCCxZjDHR20uOQ>? MYKyOVM3OjJ4MB?=
granulosa cells NGTy[5VHfW6ldHnvckBCe3OjeR?= M4TtV|ExKM7:TR?= M4fBfVEzNzJ2IHi= NF6zbXpqdmO{ZXHz[ZMhfGinIHzleoVteyCxZtMgVmdUOsLibWLORS=> MnjENlU{OzlzMEW=
granulosa cells MlnTSpVv[3Srb36gRZN{[Xl? NF7sSGUyOCEQvF2= MWCxNk8zPCCq M1r4OYlv[3KnYYPld{B1cGVibHX2[Yx{KG:oIILldI9zfGW{IHHjeIl3cXS7IH\vdkB1cGVibH;u[4V{fCCocnHncYVvfCBq4pkSPFU1NytzOGLHV|IvVFWFKR?= NX3uXHc{OjV|M{mxNFU>
granulosa cells M3HPfGZ2dmO2aX;uJGF{e2G7 M3rKSFExKM7:TR?= NWfrWpFCOjRiaB?= NYrNTIFkcW6lcnXhd4V{KHSqZTDpcpRmdnOrdImgc4YhTE6DL4Dyc5RmcW5iY3;tdIxmgA>? MUKyOVM{QTFyNR?=
granulosa cells MYrGeY5kfGmxbjDBd5NigQ>? NXLxe3lSOTBizszN NILxbJkzPCCq MVzpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCUR2OyJJBzd22xdHXyJIFkfGm4aYT5 Ml7HNlU{OzlzMEW=
SK-N-AS  NX7ZVWZiS2WubDDWbYFjcWyrdImgRZN{[Xl? MonENVAh|ryPwrC= NHLWSpIzPC92ODDo MUHlcohidmOnczD0bY1mNWSncHXu[IVvfGy7IHPlcIx2dGG{II\pZYJqdGm2edMg MoHhNlUzPjZyNkO=
SK-N-AS  NXTHVItKTnWwY4Tpc44hSXO|YYm= NGPONWIyOCEQvF5CpC=> NHP4S2szPCCq MV7pcoNz\WG|ZYOgeIhmKGODTWCgcIV3\Wy|wrC= NGnzbGMzPTJ4NkC2Ny=>
SK-N-AS  NETCR5FHfW6ldHnvckBCe3OjeR?= NH62fZAyOCEQvF5CpC=> NGLiXmczPCCq M2fac4lv[3KnYYPld{B1cGViZYjwdoV{e2mxbjDv[kBkgWOuaX6gSFE> M1H1R|I2OjZ4ME[z
SK-N-AS  M1PT[GZ2dmO2aX;uJGF{e2G7 NV;YNlNxOTBizszNxsA> NV22[4NFOzBibXnu NG\NcHdqdmS3Y3XzJJBpd3OyaH;yfYxifGmxbjDv[kDPui2lYYTlcolvKCi|ZYK2O|UqNCCyLVfTT|PPuiBqc3XyPUkh[W6mIHPvcoNwdWm2YX70JIhq\2incjDs[ZZmdHNib3[gZYN1cX[nLDD1cpBpd3OyaH;yfYxifGWmLDFOtk1k[XSnbnnu NE\kNXczPTJ4NkC2Ny=>
SK-N-AS  NF3TSW1HfW6ldHnvckBCe3OjeR?= MX6xNEDPxE4EoB?= M3Lz[|ExNzNyL{[wJI1qdg>? MlK1bY5kemWjc3XzJIxmfmWuczDv[kBxNc7{LXPheIVvcW5iKIPldlY4PSliYX7kJIlv\HWlZYOgZYNkfW23bHH0bY9vKG:oIICt{tIu[2G2ZX7pckApe2W{Nke1LUBqdiBqcHXybUlvfWOuZXHyJJJm\2mxboO= NH62OFIzPTJ4NkC2Ny=>
SK-N-SH NIXodYlE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NV7CO|h2OTBizszNxsA> MUG0PEBp Ml[5[Y5p[W6lZYOgV2suVi2VSDDu[ZVzd2KuYYP0c41iKGOnbHygeoli[mmuaYT5 MYKyOVI3PjB4Mx?=
HEK‐CFTR Mn7kSpVv[3Srb36gRZN{[Xl? MXyy5qCUPTEEoN88US=> MoHFNE0yOiCvaX6= NXjCTYw5TE2VT9Mg NXOzZ|FZcW6mdXPld{BiKGSxc3ZihLBl\XCnbnTlcpQhcW:maXTlJIVn\my3eNMg NUnSN3M6OjV{NkOyNFc>
L6 NG[3OmJHfW6ldHnvckBCe3OjeR?= M3nTZVQxKML3TR?= MX2yOEBp NE\wbYxqdmirYnn0d{BFVUhzLXnu[JVk\WRiQXv0JIFkfGm4YYTpc44> NEHsRZozPTJ2N{W1NC=>
MIN6  M2XFSGZ2dmO2aX;uJGF{e2G7 MonYNVAh|ryPwrC= M371SFMhcA>? NIjR[3FqdmO{ZXHz[ZMhTDNibWLORUBmgHC{ZYPzbY9v MUmyOVI1OTF{NB?=
ventricular cardiomyocytes  M{XKT2Z2dmO2aX;uJGF{e2G7 NXGyfWZ4OC5yMT2xNEDPxE1? M3m3Wolv[3KnYYPld{Ah[0GPUDDhZ4N2dXWuYYTpc44> MYWyOVIxOzFzMx?=
ventricular cardiomyocytes  M1;seWZ2dmO2aX;uJGF{e2G7 MXmwMlAyNTFyIN88US=> M3rETIV3d2unczDhckBqdm:2cn;wbYMhemW|cH;ud4UhOTJywsGxOUUh[WKxdnWgZoF{[Wxid3n0bEBidiCHQ{WwxsBw\iB{LkKgxtVO M2HKO|I2OjB|MUGz
BeWo  MXfGeY5kfGmxbjDBd5NigQ>? M{PoW|IxKML3TR?= NEL5VmE1QCCq M1vXSWROW00EoB?= NFzJblBqdmS3Y3XzJINmdGxiZoXzbY9v MWGyOVE5PDR5Nx?=
THP-1  NFvq[oNHfW6ldHnvckBCe3OjeR?= NXLhVIVHOS9zMDFOwG0> M4i0[|LDqGh? NUXTVFNbTE2VT9Mg NInLOHB{fXCycnXzd4V{KE2FUD2xJJBzd2S3Y4Tpc47DqA>? Ml7kNlUyPTR6OEK=
Huh-7 MY\GeY5kfGmxbjDBd5NigQ>? MnzYNE0zOCEQvF2= MVyyJIjDqA>? MkjDdoV{fWy2czDpckBiKGSxc3Wt[IVx\W6mZX70JIlv[3KnYYPlJIlvKGNvTYnjJIV5eHKnc4Ppc44h[XRidHjlJJBzd3SnaX6gZY5lKG2UTlGgcIV3\Wy| M{nFZlI2OTB7OEO0
C6 M4fHPGZ2dmO2aX;uJGF{e2G7 NFO1c3MyOCEQvF5CpC=> M{jhZ|IxKG2rbh?= NUfwV3dpcW6lcnXhd4V{KGODTWCgZYNkfW23bHH0bY9v NVXhcoR3OjVyNkm0NVc>
SW480 NHHiVlVHfW6ldHnvckBCe3OjeR?= MlLGOFDDqM7:TR?= M2q5c|Q5yqCq M2TYOWROW09? NGr5bXBi[3SrdnH0[ZMhWFB{QR?= M3jVSVI1QTl5NEWx
HT-29  M17od2Z2dmO2aX;uJGF{e2G7 MYe0NOKh|ryP M1XQO|Q5yqCq MnLrSG1UVw>? MYnhZ5RqfmG2ZYOgVHAzSQ>? NWfpdWNsOjR7OUe0OVE>
SW480 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO1OFDDqM7:TR?= MWSwMVczKGh? MonCSG1UVw>? M4WxbYlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> MkG0NlQ6QTd2NUG=
HT-29  M{m2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:3PGR2PDEEoN88US=> NEP1[HgxNTd{IHi= M2LrOGROW09? Mm[ybY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> M{X5bVI1QTl5NEWx
SW480 NVjwSWhGTnWwY4Tpc44hSXO|YYm= NULBNFFTPDEEoN88US=> M3q0fVch\A>? NIPPblFFVVOR M1zybpJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= NGrTOm0zPDl7N{S1NS=>
HT-29  M2jBfmZ2dmO2aX;uJGF{e2G7 MYW0NOKh|ryP NEjRXXY4KGR? Mn34SG1UVw>? NWD0fGdFemWmdXPld{Bkd2yxbn;zdIhmemViZn;ycYF1cW:wIHPhdIFjcWyrdIpCpC=> M3rYO|I1QTl5NEWx
SW480 MkP6RZBweHSxc3nzJGF{e2G7 M1PNbFQxyqEQvF2= M3HGb|Q5yqCq NHTrc4dFVVOR MXXpcoR2[2W|IHHuJIFkfGm4YYTpc44hd2ZiY3HzdIF{\SB|L{e= M1;QcVI1QTl5NEWx
HT-29  NGjVbplCeG:ydH;zbZMhSXO|YYm= MXK0NOKh|ryP NILYOlY1QMLiaB?= MYTEUXNQ MmC3bY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 M3izWVI1QTl5NEWx
SW480 NVqzVVY5SXCxcITvd4l{KEG|c3H5 MYm0NOKh|ryP MkfHOFjDqGh? MXfEUXNQ Mlz6bY5lfWOnczDjbIFv\2W|IHnuJJRp\SCyaH;zdIhwenmuYYTpc44he3SjdIXzJI9nKFCSMlGgeIFz\2W2cx?= NGLYdGozPDl7N{S1NS=>
HT-29  MnnGRZBweHSxc3nzJGF{e2G7 M3PXNlQxyqEQvF2= M4DPV|Q5yqCq NGXGb5lFVVOR M{W5O4lv\HWlZYOgZ4hidmenczDpckB1cGVicHjvd5Bpd3K7bHH0bY9vKHO2YYT1d{Bw\iCSUELBJJRiemendIO= MkT5NlQ6QTd2NUG=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
in solvent
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID