Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

Size Price Stock Quantity  
In DMSO USD 140 In stock
USD 110 In stock
USD 270 In stock
USD 370 In stock
USD 570 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NUPmdZJpTnWwY4Tpc44hSXO|YYm= M1HHb|ExKM7:TR?= NILJWG03KGh? MYnpcoNz\WG|ZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJI93\XKneIDy[ZN{\WRiS1zIUFMh[XRiU{SzNy=> NYfte2kyOjZ2M{W0PVg>
Mo-DCs M17EZ2Z2dmO2aX;uJGF{e2G7 MoXtOVAh|ryP M2\aXFI16oDLaB?= Ml7NdJJwdW:2ZYOgTWwuOjNicILv[JVkfGmxbjDpckB1cGVic4Xw[ZJv[XSjboSgc4Yhgnmvb4PhckB{fGmvdXzheIVlKE2xLVTDd:Kh NEPSUG0zPjRzMkm0PC=>
RBMECs  M3H0bGZ2dmO2aX;uJGF{e2G7 M4roSlXDqM7:TR?= MXKxxsBp MXzicI9kc3NidHjlJHJi[zFiaX7hZ5RqfmG2aX;uJIlv\HWlZXSgZpkhTU2DUD3JTS=> MojZNlY{PThyM{m=
INA-6 MUnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MUewMVExOCEQvF2= M3fv[Vcz6oDLaB?= M{juWIlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 NUjCcnA{OjZ|ME[2NlQ>
OPM-2 M4L6T2NmdGxiVnnhZoltcXS7IFHzd4F6 NG\OemkxNTFyMDFOwG0> NUnVWlBzPzMkgJno M1PafYlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 MkLCNlY{ODZ4MkS=
U266 M3W3ZmNmdGxiVnnhZoltcXS7IFHzd4F6 MWOwMVExOCEQvF2= Mk\tO|LjiImq M3\tOolv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 M3XmRlI3OzB4NkK0
H929 MknZR4VtdCCYaXHibYxqfHliQYPzZZk> M3m3TlAuOTByIN88US=> M2jJc|cz6oDLaB?= Ml\6bY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= M{DUZVI3OzB4NkK0
RPMI 8226 NI\5e4VE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NEPzXnMxNTFyMDFOwG0> NWrWR3dXPzMkgJno NYq4fHRXcW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> MkTsNlY{ODZ4MkS=
MDCK  Mn7DSpVv[3Srb36gRZN{[Xl? MmKxNVAhyrWP MYSyOEBp NFHZT3lFVVOR MVr1dJJm\3WuYYTld{B1cGViZYjwdoV{e2mxbjDv[kBVT0ZvzsKxJIFv\CCFVFfGxsA> Mk[wNlYzODJ|NUK=
MDCK  MlvMSpVv[3Srb36gRZN{[Xl? MnG1NVAhyrWP MlTsNlQhcA>? NUHUVWcxTE2VTx?= NFXBW|JqdmirYnn0d{B1cGViaX7jdoVie2WmIHX4dJJme3Orb36gc4YhTk5iY3H1d4VlKGK7IGTHSk3PujF? Mk\NNlYzODJ|NUK=
Spinal cords  M{PYNGZ2dmO2aX;uJGF{e2G7 MWmxxsDPxE1? M1:yeFMxKG2rbh?= M33mVJN1cW23bHH0[ZMh[0GPUDDs[ZZmdHN? NGDKXYszPjF{NkmyOi=>
BeWo  MU\GeY5kfGmxbjDBd5NigQ>? M2mwPVI26oDLzszN M{nIXVI1NzR6L{eyJIg> MUfs[YFleyC2bzDhckBqdmO{ZXHz[UBqdiC2aHWg[ZhxemW|c3nvckBw\iCxdHjldkBnfXOrb36gcYFzc2W{cx?= M1;LUlI3ODV|NUS5
bovine oocytes MYLGeY5kfGmxbjDBd5NigQ>? NHz0[FMyODEEoN88US=> MoTqNVLDqGh? MkXxbY5pcWKrdIOgeIhmKGWoZnXjeEBw\iCQUGDBJIFv\C:xcjDOVHBEKHSxIIP0bY12dGG2ZTDy[ZN2dXC2aX;uJI9nKG2naX;zbZM> NHn2S2ozPjB3MU[xNS=>
Caco-2  NF\aW2NHfW6ldHnvckBCe3OjeR?= NHfKZWUxNjFxMT:xNEDPxE1? M4jRR|IxyqCvaX6= MWPpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7jdoVie2ViaX6gbY51emGlZXzseYxieiClQV3QJIxmfmWucx?= NWfNeZhtOjZyNEmxNFI>
Caco-2  Mn;nSpVv[3Srb36gRZN{[Xl? MljKNE4yNzFxMUCg{txO M17nUlI1KGh? MU\pcoNz\WG|ZYOgUXJROiCycn;0[YlvKGyndnXs NFzKRnQzPjB2OUGwNi=>
AML-12  NXjHO4QzTnWwY4Tpc44hSXO|YYm= MWWyNEDPxE1? NIjO[mg{KGh? NW\YXoNFfXC{ZXf1cIF1\XNidHjlJJBpd3OyaH;yfYxifGmxbjDs[ZZmdHNiYYSgWIhzNTRzMTDhcoQhW2W{LUS5Ny=> NVXt[WVQOjZyNEi5PFU>
AML-12  MoDwSpVv[3Srb36gRZN{[Xl? Mn3WNlAh|ryP NIDmc3MyNThiaB?= NGHaO49qdmO{ZXHz[ZMh\2y3Y3;z[UBxem:mdXP0bY9v NXiybHlGOjZyNEi5PFU>
AML-12  NHXKfFVHfW6ldHnvckBCe3OjeR?= NW\USJFLOjBizszN M1PlcVMhcA>? M3T1NpVxNXKnZ4XsZZRme8LiUHfjNYEtyqCSZYDjb{wh[W6mwrDHOpBkyqCvUl7BJIxmfmWucx?= NW\pTZZoOjZyNEi5PFU>
AML-12  MWXGeY5kfGmxbjDBd5NigQ>? NFvjVGEzOCEQvF2= NVzoWmJ{OyCq M{\GdIlv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKG:oIFPSWGMzyqB? M2LYPVI3ODR6OUi1
RBMECs M3;YZmZ2dmO2aX;uJGF{e2G7 M{[1OFXDqM7:TR?= MV2xJIg> M{PNe4lvcGmkaYTzJGVOSVBvSVmtbY5lfWOnZDDpcoFkfGm4YYTpc44hd2ZiUnHwNeKh NGT4So8zPjB2NE[2Ny=>
EndoC-βH1 NGDXfXhHfW6ldHnvckBCe3OjeR?= M2XWcVXDqM7:TR?= M3W1WFEhcA>? NGHkbIlxd3SnboTpZZRmeyCpbIXjc5NmNWmwZIXj[YQhcW6|dXzpckB{\WO{ZYTpc44hcW5idHjlJJBz\XOnbnPlJI9nKGeudXPvd4U> Ml3BNlYxOjh3NkK=
EndoC-βH1 NUPnboFZTnWwY4Tpc44hSXO|YYm= MnXPOeKh|ryP MoPNNUBp NF3DU2lt\WGmczD0c{BiKHO2cn;u[{BkSU2SIHnuZ5Jm[XOn NI[1boMzPjB{OEW2Ni=>
SH-SY5Y MkfQSpVv[3Srb36gRZN{[Xl? NFjZRm8{OCEQvF2= NGXxXYg{OCCvaX6= NFzrTmJFVVOR M2Pke5Nq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBi[3SrdnH0bY9vKG:oIGDLRS=> MUiyOlAzPTF|Nx?=
PC-3 MXjGeY5kfGmxbjDBd5NigQ>? NF3ldVM1OCEEtV2= NH\iZ2YzKGh? MWPEUXNQ M{DLXoxm[WS|IITvJHBROkFiYXP0bZZifGmxbh?= MV:yOlAzOzh|Nh?=
PC-3 M2P2NmNmdGxiVnnhZoltcXS7IFHzd4F6 NHvp[XU1OCEEtV2= MmjvNlQwPDhxN{KgbC=> M3X1bmROW09? NXTCbJN2\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJRqdWViZHXw[Y5l\W62bIm= NUXvPItQOjZyMkO4N|Y>
SCG NHTDdXpHfW6ldHnvckBCe3OjeR?= MmnSNlAh|ryPwrC= NXjRcJlkTE2VTx?= MoPidoV3\XK|aXLsfUB{fXCycnXzd4V{KEmNVjD3bZRpKGFiSVO1NEBw\iB{ND60JO69VQ>? MkniNlU6PjJzM{K=
HEK-293 NUi5O2RxTnWwY4Tpc44hSXO|YYm= NWnteYx5OzVizszNxsA> M4H1UGROW09? MYnpcoR2[2W|IHGgZ49ve3CrY4XveZMh6oDeaX7hZ5RqfmG2aX;u5qCeKG:oIITo[UBMfjJwMTDjeZJz\W62 MXyyOVk3OjF|Mh?=
SCG NGnBXG5HfW6ldHnvckBCe3OjeR?= NVT4XZZvOTByIN88UeKh NFyzdIhFVVOR M3:yPJJm\HWlZYOgeIhmKGW6Y3n0ZYJqdGm2eTDv[kBUS0dibnX1do9vew>? M4j4dVI2QTZ{MUOy
PCCL3 NIrwRlVHfW6ldHnvckBCe3OjeR?= NVnhbHFFOTBiwsXN MWCyOEBp MX7lcohidmOnczDEeW95OiCycn;tc5RmeiC2cnHud4NzcXC2aX;uJIFkfGm4aYT5xsDjiIt? NEHxRZQzPTl4MEm1Oi=>
3T3-L1 preadipocytes M{HrZmZ2dmO2aX;uJGF{e2G7 MX6xNEDPxE4EoB?= M2jaNFEzKGh? MVTpcoR2[2W|IFPSSWIheGixc4Doc5J6dGG2aX;uJIFv\CCFL1XCVO6zKGW6cILld5Nqd25? NF\ERm8zPTl{OEC1PC=>
H295R  M1LXOWZ2dmO2aX;uJGF{e2G7 NUHK[XpjOTEEoN88US=> MYq0POKhcA>? MoL4bY5kemWjc3XzJJN1\XKxaXSgcYV1[WKxbHn0[ZMhcW5idHjlJIFv\HKxZ3XuMEBucW6ncnHsc{0h[W6mIHfseYNw[2:{dHnjc4llKHCjdHj3ZZl{ MoTDNlU5Pjl3NU[=
PBMC MkHaSpVv[3Srb36gRZN{[Xl? M2DCZlUxyqEQvF2= Ml7jNlTDqGkEoB?= M1zSVYlvcGmkaYTzJJRp\SCrbnPy[YF{\WRic3XjdoV1cW:wIH;mJHRPTiCrbnT1Z4VlKGK7IITo[UBFWEV? MXyyOVg3PjB5OR?=
GLUTag  NHHveoJHfW6ldHnvckBCe3OjeR?= M1XV[lEx6oDLwsXN MYWwM|IwPCCq NWnMZo5xe3SrbYXsZZRmeyCJTGCtNUB{\WO{ZYTpc44h[2:2cnXheIVlKHerdHigTWJOYA>? MnTqNlU5OzJ4M{G=
GLUTag  M2fPO2Z2dmO2aX;uJGF{e2G7 NVjNXHo4OTEkgJpCuW0> NH7PSoM1KGh? MoXZbY5kemWjc3XzJJRp\SCyQ2LFRkBt\X[nbIOge4l1cCC2aHWgTWJOYA>? NXruT3BHOjV6M{K2N|E>
BAECs M4HHSWZ2dmO2aX;uJGF{e2G7 MYOyOUDPxE1? NHnGNI8zPCCq M3nV[YVvcGGwY3XzJJRp\SCjY4TpeoF1cW:wIH;mJHBRSVMQsTDifUA2KM7:TTDy[ZN3\XKjdILvcEwhXDSKUzygc5IhPC2SQWC= NUDQOWhjOjV5OUi4NlY>
PC12 MXLGeY5kfGmxbjDBd5NigQ>? MnPzNlXDqM7:TR?= Mor5OFghcA>? MX3hZ5RqfmG2ZYOgZ2FOWA>? Ml20NlU4Pjl|MEW=
GH3 MWjGeY5kfGmxbjDBd5NigQ>? MXGxxsDPxE1? MmnSOk1p MUHheJRmdnWjdHXzJJRp\SClb4Ly[YxifGmxbjDi[ZR4\WWwIGDSUEBidmRiQn3hcFEh\XiycnXzd4lwdg>? MVOyOVczPzBzOB?=
GH3 NHHIdHJHfW6ldHnvckBCe3OjeR?= MlK1NeKh|ryP NGWxNIQ3NWh? M33h[olv\HWlZYOgVHJNKGGwZDDCcYFtOSxiYoX0JI5wfCCFbH;jb{whdVKQQTDlfJBz\XO|aX;u MXeyOVczPzBzOB?=
BeWo NYr1bZBPTnWwY4Tpc44hSXO|YYm= M2LCXFEx6oDMzszNxsA> NX7WUpFSPzJiaB?= MlW0SG1UVw>? MWjt[YRq[XSnczDC[XdwKGOnbHyg[Iln\mW{ZX70bYF1cW:w NX73PJpXOjV5MUO0NlU>
oocytes MY\GeY5kfGmxbjDBd5NigQ>? MWG1JO69VQ>? NH;CWXIzPCCq M362OoF1fGWwdXH0[ZMhemhvaX7zeYxqdiCjY4Tpc44hd25ib3;jfZRmKEeYQlSgd4lodmmoaXPhcpRtgcLi NVG5bYNbOjV5MEe4OVQ>
SC M1\5XWZ2dmO2aX;uJGF{e2G7 NET0UFAxNjVizszN MXOyOEBp M3f4ZY1qdWmla4OgeIhmKGWoZnXjeEBw\iClQV3QJIFv[WyxZ4Ogc44hVzFiYX7kJG1DWCCneIDy[ZN{cW:w MVqyOVcxPTh5NB?=
SC MVjGeY5kfGmxbjDBd5NigQ>? MVywMlUh|ryP M3LsRlczKGh? NYDi[YZ4cW6lcnXhd4V{KGKxdHigT5JwgC1{MDDhcoQhVzFiZYjwdoV{e2mxbjDpckBigG:wLYLlcIF1\WRiU1PzJIJ2fCCxbnz5JGtzd3hvMkFCpC=> NVP6fohvOjV5MEW4O|Q>
UACC-647  MWjGeY5kfGmxbjDBd5NigQ>? NELCVmdFVVOR MWjs[YFleyC2bzDhJJJqe2ViaX6gZ2FOWCCuZY\lcJMhMEWFNUFCpF3DqDJyLkO5xsDPxE1r MXqyOVcxOzB{NR?=
UACC-647  NXnOXIVCTnWwY4Tpc44hSXO|YYm= NXLjPZVpOTEEoN88US=> NGXDZWkyPSCvaX6= MYjEUXNQ MUTpcohq[mm2czDFVmsheGixc4Doc5J6dGG2aX;u NYf1PZpFOjV5MEOwNlU>
UACC-647  Moi1SpVv[3Srb36gRZN{[Xl? NV;ufIl2OTEEoN88US=> MV[xOUBucW5? M2mwZ2ROW09? MWjpcoNz\WG|ZYOg[WVHOiCyaH;zdIhwenmuYYTpc44hdGW4ZXzzxsA> NXnuZnNLOjV5MEOwNlU>
SH-SY5Y  MV3GeY5kfGmxbjDBd5NigQ>? NIrkS5EyOMLizszN MWGxxsBpyqB? NXXac3NQcW6lcnXhd4V{KEyXQzDhZ5Rqfmm2eR?= MVqyOVU6PzR|Mx?=
SH-SY5Y  MXHGeY5kfGmxbjDBd5NigQ>? NUG3RnNpOTEEoN88US=> MXexxsBpyqB? Mom3bY5kemWjc3XzJGFISzFibWLORUBt\X[nbB?= NIjoXIEzPTV7N{SzNy=>
hADSCs NY\pdGhjTnWwY4Tpc44hSXO|YYm= MW[15qCKyrWP NVXPWW8{OzBibXnu MoexbY5kemWjc3XzJINCVVBibHX2[Yx{ NYH0eIg{OjV3OUG5NFg>
HEK293  MkLBSpVv[3Srb36gRZN{[Xl? NGTCOHM26oDLwsXN NXnYfGlDOzBibXnu MV\pcoNz\WG|ZYOgZ2FOWCCuZY\lcJM> NY\rfVQ1OjV3OUG5NFg>
3T3-L1 NFGzNmZHfW6ldHnvckBCe3OjeR?= NHSyemszNjVxNTFOwG0> NG\SeHMzPCCqwrC= M3\ScJNq\26rZnnjZY51dHliZHXjdoVie2W|IFHUS2wheHKxdHXpckBmgHC{ZYPzbY9vKGG2IHHscEBld3OnczD0[ZN1\WR? NV74VVBbOjV3OUC1PVc>
OCI-Ly1  M13zWmZ2dmO2aX;uJGF{e2G7 M3XTelQxyqEQvF2= MXOxxsBpyqB? M3vROWROW09? MkjGbY5lfWOnczD0bIUhcW6lcnXt[Y51KG:oIHPBUXAh[2:wY3XueJJifGmxboO= M2LBPFI2PTd4MkKw
OCI-Ly18  M2jqc2Z2dmO2aX;uJGF{e2G7 NIHyRmo1OMLizszN MYexxsBpyqB? MV7EUXNQ NG\nO3JqdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> NGK2R24zPTV5NkKyNC=>
BeWo M2rqXWZ2dmO2aX;uJGF{e2G7 M3voSFIxyqEEtV2= MVK0POKhcA>? NV[3co1jTE2VTx?= NUOzfmZwcW6lcnXhd4V{KHSqZTDkbYZn\XKnboTpZZRqd25ib3[gRoVYdyClZXzsdy=> NXO4Vpd4OjV3Nk[3OFA>
BeWo M3:0WmZ2dmO2aX;uJGF{e2G7 M3PwNFIxyqEEtV2= Mk[yOFjDqGh? MoPiSG1UVw>? MUPpcoNz\WG|ZYOgeIhmKGGmaHXzbY9vKG:oIGTIVE0yKG2xbn;jfZRmew>? MVyyOVU3Pjd2MB?=
LNCaP  NIDKPY9HfW6ldHnvckBCe3OjeR?= M{LaVFExyqEQvF2= NIWyXnUyOiCqwrC= NX3BfFRCTE2VTx?= NV;lRolEcW6mdXPld{BiKGS{YX3heIlkKGmwY4LlZZNmKG:oIFPSSWIyKGGldHn2bZR6 MoThNlU2PDhyOUm=
ThGCs  NYLo[IVTTnWwY4Tpc44hSXO|YYm= NVu5WFc1OTEkgJtOwG0> MlHwOQKBkmh? MVrheYdu\W62czDITWYySSCuZY\lcJMhfGijdDD3[ZJmKHO2aX31cIF1\WRiYomgR49EdDJ? MU[yOVQ{OzB{Nx?=
ThGCs  NHXrO5BHfW6ldHnvckBCe3OjeR?= MXmxNQKBks7:TR?= M2\jZlTjiIqq NYj3[oFxcW6lcnXhd4V{KEOxQ3yyMYlv\HWlZXSgSWRPOsLiZ3Xu[UBmgHC{ZYPzbY9v MmPwNlU1OzNyMke=
ThGCs  MkDsSpVv[3Srb36gRZN{[Xl? MW[xNQKBks7:TR?= MX2zJIg> NXXCN4JocW6qaXLpeJMhfGinIHXm[oVkfCCxZjDINm8zKG:wIFXEUlIhdVKQQR?= NF;rXYQzPTR|M{CyOy=>
RBMECs MkXaSpVv[3Srb36gRZN{[Xl? M3LjUFAvODVxMD61M|Uh|ryP M1j6U|AvOjViaB?= Mk\kbY5kemWjc3XzJINCVVBiY3;uZ4VvfHKjdHnvci=> MYiyOVQyPjZ3MR?=
RBMECs NHvkS3NHfW6ldHnvckBCe3OjeR?= M2nPe|XDqM7:TR?= M1fXfFEhcA>? MnLOZoxw[2u|IITo[UBi[3SrdnH0bY9vKG:oIGLoc2EwWk:FSzDpcoR2[2WmIHL5JGVOSVBvSVm= NEj4NXczPTRzNk[1NS=>
RBMECs NH\kWZJHfW6ldHnvckBCe3OjeR?= MYS1xsDPxE1? NWPmN5pCOSCq MVjwdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> M3PK[FI2PDF4NkWx
RBMECs NWDHOYROTnWwY4Tpc44hSXO|YYm= NYnyeIpHPcLizszN M1qwVVEhcA>? NFq0Z2JxemW4ZX70d{B1cGViaX7jdoVie2ViaX6gTHJRKG[udYigZYNzd3O|IITo[UBDXEJiaX7keYNm\CCkeTCgSW1CWC2LSR?= NIXGN3UzPTRzNk[1NS=>
RBMECs M{jzZmZ2dmO2aX;uJGF{e2G7 Mn7oOeKh|ryP NYHTN491OSCq MUXpcohq[mm2czD0bIUh\GWlcnXhd4VlKG:oIHHtc5VvfCCxZjDaU{0yKGmwIF3Gd{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NIHqeoQzPTRzNk[1NS=>
RBMECs NVTx[lQ5TnWwY4Tpc44hSXO|YYm= M1L0PFXDqM7:TR?= M4rpRlEhcA>? NWLVTFQzemW4ZYLz[ZMhfGinIHPoZY5o\XNiaX6gXm8uOSCmaYP0doljfXSrb36gd4VmdiC5aYToJGVOSVBvSVmgeJJm[XSvZX70 M2TQ[|I2PDF4NkWx
RBMECs Mlr0SpVv[3Srb36gRZN{[Xl? Mk\OOeKh|ryP NYnpdpJ[OSCq NXLwToR5[myxY3vzJJRp\SCHTVHQMWlKNWmwZIXj[YQh[2ijbnflJIlvKE2OQzDwbI9{eGixconsZZRqd25? NFvTWoMzPTRzNk[1NS=>
RBMECs MXzGeY5kfGmxbjDBd5NigQ>? NV\WcZZuPcLizszN NUH4WYgzOSCq NIHVW2RjdG:la4OgeIhmKGGldHnuJIN6fG:|a3Xs[ZRwdiC{ZXHydoFv\2WvZX70JJNm\W5id3n0bEBGVUGSLVnJJJRz\WG2bXXueOKh M3PaSlI2PDF4NkWx
Primary bovine chondrocytes MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\HOe69VQ>? M{Dj[VQ5KGh? NWLvSVN1emW4ZYLz[ZMhfGinIHnubIljcXSxcomg[YZn\WO2IH;mJINmdGWlb4jpZkBwdiCycn;sbYZmemG2aX;uJIlvKGe{b4f0bEBxdGG2ZTDjbI9v\HKxY4n0[ZM> MWmyOVQxPjBzNh?=
EM1  M3[xcmZ2dmO2aX;uJGF{e2G7 NWT3SoRkOTYkgJtOwG0> NFuxZZA1QCCq NYW4U4FFemWmdXPld{B1cGViZYjwdoV{e2mxbjDv[uKhVEmIwrDvduKhWFSJU{NCpIlvyqCFQVzSMUBwesLiRWDBR|Iue2muZX7j[YQhTU1zIHPlcIx{yqB? NGf5eVgzPTN5OE[2NS=>
BeWo  M{fFUGZ2dmO2aX;uJGF{e2G7 MlfNNlDDqML3TR?= M1LRWlQ5yqCqwrC= NILxUVFFVVORwrC= MVnpcoNz\WG|ZYOgeIhmKGKndHGtbGNIKHKnbHXhd4U> MnrFNlU{PjJ{NkC=
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granulosa cells NVe0cGdqTnWwY4Tpc44hSXO|YYm= NVvF[JBTOTBizszN NVvsT3JzOTJxMkSgbC=> MlvobY5kemWjc3XzJJRp\SCuZY\lcJMhd2cEoGLHV|LDqG2UTlG= M3z0dVI2OzN7MUC1
granulosa cells MnG4SpVv[3Srb36gRZN{[Xl? NIS3flIyOCEQvF2= M2PVR|EzNzJ2IHi= M3LSR4lv[3KnYYPld{B1cGVibHX2[Yx{KG:oIILldI9zfGW{IHHjeIl3cXS7IH\vdkB1cGVibH;u[4V{fCCocnHncYVvfCBq4pkSPFU1NytzOGLHV|IvVFWFKR?= MWCyOVM{QTFyNR?=
granulosa cells M2fPOmZ2dmO2aX;uJGF{e2G7 MnTiNVAh|ryP Mlm4NlQhcA>? NYe3eW5UcW6lcnXhd4V{KHSqZTDpcpRmdnOrdImgc4YhTE6DL4Dyc5RmcW5iY3;tdIxmgA>? NHSwOVEzPTN|OUGwOS=>
granulosa cells NX;SSppjTnWwY4Tpc44hSXO|YYm= NHPCVFkyOCEQvF2= M2HtWVI1KGh? NV3JNlhTcW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gVmdUOiCycn;tc5RmeiCjY4Tpeol1gQ>? M{jSTlI2OzN7MUC1
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SK-N-AS  NGrUU4VHfW6ldHnvckBCe3OjeR?= Mn\1NVAh|ryPwrC= MYGxNE8{OC94MDDtbY4> MV;pcoNz\WG|ZYOgcIV3\Wy|IH;mJJAu|rJvY3H0[Y5qdiBqc3XyOlc2MSCjbnSgbY5lfWOnczDhZ4N2dXWuYYTpc44hd2ZicD5Otk1k[XSnbnnuJEh{\XJ4N{WpJIlvKCiyZYLpLY52[2ynYYKgdoVocW:wcx?= MVKyOVI3PjB4Mx?=
SK-N-SH NXXUcJJZS2WubDDWbYFjcWyrdImgRZN{[Xl? MXuxNEDPxE4EoB?= NHf5R2I1QCCq M3PSSoVvcGGwY3XzJHNMNU5vU1igcoV2em:kbHHzeI9u[SClZXzsJJZq[WKrbHn0fS=> M4XjOVI2OjZ4ME[z
HEK‐CFTR Mm\BSpVv[3Srb36gRZN{[Xl? MoXlNwKBmzVywrFOwG0> M3PsRVAuOTJibXnu MUnEUXNQyqB? NIC1ToFqdmS3Y3XzJIEh\G:|ZfMAlIRmeGWwZHXueEBqd2SrZHWg[YZndHW6wrC= Mn[4NlUzPjN{MEe=
L6 MULGeY5kfGmxbjDBd5NigQ>? MX[0NEDDvU1? M3q3T|I1KGh? NYjPO5pXcW6qaXLpeJMhTE2KMT3pcoR2[2WmIFHreEBi[3SrdnH0bY9v MWmyOVI1PzV3MB?=
MIN6  MnHVSpVv[3Srb36gRZN{[Xl? NGKxfYEyOCEQvF5CpC=> NF;CT5c{KGh? NWPIVppKcW6lcnXhd4V{KER|IH3SUmEh\XiycnXzd4lwdg>? M3\oVlI2OjRzMUK0
ventricular cardiomyocytes  MV3GeY5kfGmxbjDBd5NigQ>? NED6O|ExNjBzLUGwJO69VQ>? MnvUbY5kemWjc3XzJEBkSU2SIHHjZ5VufWyjdHnvci=> MX6yOVIxOzFzMx?=
ventricular cardiomyocytes  M2nJOWZ2dmO2aX;uJGF{e2G7 M{XlXVAvODFvMUCg{txO M1\1WYV3d2unczDhckBqdm:2cn;wbYMhemW|cH;ud4UhOTJywsGxOUUh[WKxdnWgZoF{[Wxid3n0bEBidiCHQ{WwxsBw\iB{LkKgxtVO MVeyOVIxOzFzMx?=
BeWo  MlPRSpVv[3Srb36gRZN{[Xl? NHrodowzOCEEtV2= NYX1Tms4PDhiaB?= MWjEUXNQyqB? M{HtPIlv\HWlZYOgZ4VtdCCodYPpc44> M3WyTFI2OTh2NEe3
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SW480 M2XuVGZ2dmO2aX;uJGF{e2G7 MoX5OFDDqM7:TR?= MnK4OFjDqGh? M1jo[GROW09? NIXkVG9i[3SrdnH0[ZMhWFB{QR?= NVTNfmk3OjR7OUe0OVE>
HT-29  NIOzfmZHfW6ldHnvckBCe3OjeR?= M4PvfVQxyqEQvF2= NVLXTpZbPDkEoHi= NF;zflJFVVOR NF61VGRi[3SrdnH0[ZMhWFB{QR?= NH32WHYzPDl7N{S1NS=>
SW480 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYK0NOKh|ryP NWXIOHVLOC15MjDo MlfHSG1UVw>? M{SzNYlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> M3\jSVI1QTl5NEWx
HT-29  NUfRZZdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3yVIc1OMLizszN M32ycVAuPzJiaB?= NInJfG9FVVOR NFXndYtqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lJIRmeGWwZHXueIx6 NIPQeZUzPDl7N{S1NS=>
SW480 M3f5UGZ2dmO2aX;uJGF{e2G7 MkHLOFDDqM7:TR?= M1;uVFch\A>? NUm4fIgyTE2VTx?= MUXy[YR2[2W|IHPvcI9vd3OyaHXy[UBnd3KvYYTpc44h[2GyYXLpcIl1gcLi M2TEfVI1QTl5NEWx
HT-29  M1LNXmZ2dmO2aX;uJGF{e2G7 MkXjOFDDqM7:TR?= NV;lUWVCPyCm MmDtSG1UVw>? M2HscZJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= Ml\HNlQ6QTd2NUG=
SW480 MV7BdI9xfG:|aYOgRZN{[Xl? M1vnfFQxyqEQvF2= M12wV|Q5yqCq NXn6Sml4TE2VTx?= Mn\ZbY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 NGfLe|EzPDl7N{S1NS=>
HT-29  NUXFfWVWSXCxcITvd4l{KEG|c3H5 M1KxUlQxyqEQvF2= M332UVQ5yqCq MYDEUXNQ MY\pcoR2[2W|IHHuJIFkfGm4YYTpc44hd2ZiY3HzdIF{\SB|L{e= M2HS[FI1QTl5NEWx
SW480 MnSwRZBweHSxc3nzJGF{e2G7 M3PTdVQxyqEQvF2= MlG1OFjDqGh? M1S5UmROW09? Mn3BbY5lfWOnczDjbIFv\2W|IHnuJJRp\SCyaH;zdIhwenmuYYTpc44he3SjdIXzJI9nKFCSMlGgeIFz\2W2cx?= MkPhNlQ6QTd2NUG=
HT-29  NVzreIpoSXCxcITvd4l{KEG|c3H5 M1n1d|QxyqEQvF2= NW\rPWJ1PDkEoHi= MULEUXNQ NYjLV5pJcW6mdXPld{BkcGGwZ3XzJIlvKHSqZTDwbI9{eGixconsZZRqd25ic4TheJV{KG:oIGDQNmEhfGG{Z3X0dy=> M4DxblI1QTl5NEWx

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
in solvent
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID