Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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Cited by 18 Publications

3 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Western blot analysis shows pERK levels after 8 hours treatment with forskolin. AC activation with 10 μmol/L forskolin (F).

    Mol Cancer Res, 2017, 15(12):1792-1802. Forskolin purchased from Selleck.

  • Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NUKxZ3hFTnWwY4Tpc44hSXO|YYm= MmL0NVAh|ryP NUDxdmxUPiCq MUTpcoNz\WG|ZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJI93\XKneIDy[ZN{\WRiS1zIUFMh[XRiU{SzNy=> NGTJNZAzPjR|NUS5PC=>
Mo-DCs M4m0XmZ2dmO2aX;uJGF{e2G7 M4\DdlUxKM7:TR?= MX:yOQKBkWh? Mkj2dJJwdW:2ZYOgTWwuOjNicILv[JVkfGmxbjDpckB1cGVic4Xw[ZJv[XSjboSgc4Yhgnmvb4PhckB{fGmvdXzheIVlKE2xLVTDd:Kh NXfpXmJbOjZ2MUK5OFg>
RBMECs  NFWydI9HfW6ldHnvckBCe3OjeR?= M1vGb|XDqM7:TR?= NULBRXg5OcLiaB?= NUHKXXhP[myxY3vzJJRp\SCUYXOxJIlv[WO2aY\heIlwdiCrbnT1Z4VlKGK7IFXNRXAuUUl? MmXmNlY{PThyM{m=
INA-6 NXTmRlJ1S2WubDDWbYFjcWyrdImgRZN{[Xl? M2HyN|AuOTByIN88US=> MmSzO|LjiImq NFXJZYZqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> M3LuR|I3OzB4NkK0
OPM-2 M{jpSGNmdGxiVnnhZoltcXS7IFHzd4F6 MlnrNE0yODBizszN NFfyemc4OuLCiXi= MXzpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= MVOyOlMxPjZ{NB?=
U266 NF\QUlNE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NF\2c20xNTFyMDFOwG0> NXz0ZWc{PzMkgJno NHLRd2tqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> M3TpblI3OzB4NkK0
H929 MX3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NHXzNooxNTFyMDFOwG0> NHXyWVg4OuLCiXi= M3vKUYlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 MknBNlY{ODZ4MkS=
RPMI 8226 M4jNZWNmdGxiVnnhZoltcXS7IFHzd4F6 Ml3YNE0yODBizszN NXTzbopFPzMkgJno MmnObY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MmX5NlY{ODZ4MkS=
MDCK  MmPMSpVv[3Srb36gRZN{[Xl? MkfINVAhyrWP NFnn[4gzPCCq MkTTSG1UVw>? M1jEZZVxemWpdXzheIV{KHSqZTDlfJBz\XO|aX;uJI9nKFSJRj5OtlEh[W6mIFPUS2bDqA>? MmD4NlYzODJ|NUK=
MDCK  NHzuWY1HfW6ldHnvckBCe3OjeR?= NUPKNWRkOTBiwsXN NF;Fb3IzPCCq M4i3dGROW09? MW\pcohq[mm2czD0bIUhcW6lcnXhd4VlKGW6cILld5Nqd25ib3[gSm4h[2G3c3XkJIJ6KFSJRj5OtlE> Ml;CNlYzODJ|NUK=
Spinal cords  MVPGeY5kfGmxbjDBd5NigQ>? NWnZ[lNLOcLizszN Mn\XN|AhdWmw NFuwPWl{fGmvdXzheIV{KGODTWCgcIV3\Wy| M1yzdlI3OTJ4OUK2
BeWo  MnXOSpVv[3Srb36gRZN{[Xl? MXqyOgKBkc7:TR?= Mn61NlQwPDhxN{KgbC=> NXHzNHpWdGWjZIOgeI8h[W5iaX7jdoVie2ViaX6geIhmKGW6cILld5Nqd25ib3[gc5Rp\XJiZoXzbY9vKG2jcnvldpM> M1[0flI3ODV|NUS5
bovine oocytes M4q2PWZ2dmO2aX;uJGF{e2G7 MWqxNFDDqM7:TR?= MXWxNuKhcA>? NY[0c|J5cW6qaXLpeJMhfGinIHXm[oVkfCCxZjDOVHBCKGGwZD;vdkBPWFCFIITvJJN1cW23bHH0[UBz\XO3bYD0bY9vKG:oIH3lbY9{cXN? MmPZNlYxPTF4MUG=
Caco-2  M1zPcmZ2dmO2aX;uJGF{e2G7 M3;aZlAvOS9zL{GwJO69VQ>? MmPtNlDDqG2rbh?= NHL6OItqdmS3Y3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDjRW1RKGyndnXsdy=> MUOyOlA1QTFyMh?=
Caco-2  NGP1SG1HfW6ldHnvckBCe3OjeR?= NWfkdnhxOC5zL{GvNVAh|ryP Mnj2NlQhcA>? M2LNRolv[3KnYYPld{BOWlB{IIDyc5RmcW5ibHX2[Yw> M2LnNVI3ODR7MUCy
AML-12  M{DIfWZ2dmO2aX;uJGF{e2G7 NIDFWowzOCEQvF2= NGH0RWo{KGh? Mkf5eZBz\We3bHH0[ZMhfGinIIDoc5NxcG:{eXzheIlwdiCuZY\lcJMh[XRiVHjyMVQyOSCjbnSgV4VzNTR7Mx?= MkHpNlYxPDh7OEW=
AML-12  M1fQUmZ2dmO2aX;uJGF{e2G7 MXOyNEDPxE1? NV35[XB5OS16IHi= NX63fFkxcW6lcnXhd4V{KGeudXPvd4UheHKxZIXjeIlwdg>? MmnZNlYxPDh7OEW=
AML-12  MVPGeY5kfGmxbjDBd5NigQ>? NGXmeVgzOCEQvF2= M2PPO|MhcA>? M1:5fpVxNXKnZ4XsZZRme8LiUHfjNYEtyqCSZYDjb{wh[W6mwrDHOpBkyqCvUl7BJIxmfmWucx?= NWX1V41UOjZyNEi5PFU>
AML-12  NU\OV5VuTnWwY4Tpc44hSXO|YYm= NYrofIZFOjBizszN NFXGb4c{KGh? MXLpcoR2[2W|IITo[UBl\XCqb4PwbI9zgWyjdHnvckBw\iCFUmTDNuKh MmnhNlYxPDh7OEW=
RBMECs MXHGeY5kfGmxbjDBd5NigQ>? MnTYOeKh|ryP NFHETYkyKGh? MmfabY5pcWKrdIOgSW1CWC2LST3pcoR2[2WmIHnuZYN1cX[jdHnvckBw\iCUYYCxxsA> M{fyUVI3ODR2Nk[z
EndoC-βH1 NYnRNFJyTnWwY4Tpc44hSXO|YYm= MlrBOeKh|ryP MkXlNUBp M3faNJBwfGWwdHnheIV{KGeudXPvd4UucW6mdXPl[EBqdnO3bHnuJJNm[3KndHnvckBqdiC2aHWgdJJme2WwY3Wgc4Yh\2y3Y3;z[S=> M2jHWlI3ODJ6NU[y
EndoC-βH1 NETUVmpHfW6ldHnvckBCe3OjeR?= MoiyOeKh|ryP M2LiOFEhcA>? NH;uOJRt\WGmczD0c{BiKHO2cn;u[{BkSU2SIHnuZ5Jm[XOn MomzNlYxOjh3NkK=
SH-SY5Y NXTKPWFOTnWwY4Tpc44hSXO|YYm= MlvtN|Ah|ryP MkfZN|AhdWmw M3XRdGROW09? NHTsR2h{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUh[WO2aY\heIlwdiCxZjDQT2E> MWGyOlAzPTF|Nx?=
PC-3 M3;yR2Z2dmO2aX;uJGF{e2G7 NX\QTG9OPDBiwsXN Ml7mNkBp MUTEUXNQ NF;BcWRt\WGmczD0c{BRWDKDIHHjeIl3[XSrb36= MoPUNlYxOjN6M{[=
PC-3 MljqR4VtdCCYaXHibYxqfHliQYPzZZk> MX60NEDDvU1? M2q0WlI1NzR6L{eyJIg> NFfoOnNFVVOR Mlzp[IVkemWjc3XzJINmdGxidnnhZoltcXS7IITpcYUh\GWyZX7k[Y51dHl? MUWyOlAzOzh|Nh?=
SCG M{P1fmZ2dmO2aX;uJGF{e2G7 M3\XUVIxKM7:TdMg MXfEUXNQ M4\adJJmfmW{c3nicJkhe3WycILld5NmeyCLS2[ge4l1cCCjIFnDOVAhd2ZiMkSuOEDPxE1? MXmyOVk3OjF|Mh?=
HEK-293 MnjYSpVv[3Srb36gRZN{[Xl? M163R|M2KM7:TdMg M3zBNmROW09? MYfpcoR2[2W|IHGgZ49ve3CrY4XveZMh6oDeaX7hZ5RqfmG2aX;u5qCeKG:oIITo[UBMfjJwMTDjeZJz\W62 M{TxXFI2QTZ{MUOy
SCG NGD5WZRHfW6ldHnvckBCe3OjeR?= M1;mfVExOCEQvF5CpC=> Ml2ySG1UVw>? MXny[YR2[2W|IITo[UBmgGOrdHHibYxqfHlib3[gV2NIKG6ndYLvcpM> M2nMd|I2QTZ{MUOy
PCCL3 NGLTe4dHfW6ldHnvckBCe3OjeR?= NH7pb5QyOCEEtV2= MVmyOEBp MXPlcohidmOnczDEeW95OiCycn;tc5RmeiC2cnHud4NzcXC2aX;uJIFkfGm4aYT5xsDjiIt? NEDqUIQzPTl4MEm1Oi=>
3T3-L1 preadipocytes NFX4b21HfW6ldHnvckBCe3OjeR?= MnzyNVAh|ryPwrC= M1vQd|EzKGh? M2TXdYlv\HWlZYOgR3JGSiCyaH;zdIhwenmuYYTpc44h[W6mIFOvSWJR|rJiZYjwdoV{e2mxbh?= NV\QWGRWOjV7MkiwOVg>
H295R  NVPDVm1ZTnWwY4Tpc44hSXO|YYm= MkDTNVDDqM7:TR?= MXK0POKhcA>? NUTCNXB6cW6lcnXhd4V{KHO2ZYLvbYQhdWW2YXLvcIl1\XNiaX6geIhmKGGwZILv[4VvNCCvaX7ldoFtdy1iYX7kJIdtfWOxY3;yeIlkd2mmIIDheIh4[Xm| MofxNlU5Pjl3NU[=
PBMC MVnGeY5kfGmxbjDBd5NigQ>? NH:wPGI2OMLizszN MXmyOOKhcMLi NWLFV|JqcW6qaXLpeJMhfGinIHnuZ5Jm[XOnZDDz[YNz\XSrb36gc4YhXE6IIHnu[JVk\WRiYomgeIhmKESSRR?= NIjOUW4zPTh4NkC3PS=>
GLUTag  M3;MZmZ2dmO2aX;uJGF{e2G7 M1H2OVEx6oDLwsXN MoPxNE8zNzRiaB?= M3TkO5N1cW23bHH0[ZMhT0ySLUGgd4VkemW2aX;uJINwfHKnYYTl[EB4cXSqIFnCUXg> NVHCbYk2OjV6M{K2N|E>
GLUTag  MlfPSpVv[3Srb36gRZN{[Xl? M17XW|Ex6oDLwsXN NHnpeI01KGh? MUTpcoNz\WG|ZYOgeIhmKHCFUlXCJIxmfmWuczD3bZRpKHSqZTDJRm1Z MU[yOVg{OjZ|MR?=
BAECs MUXGeY5kfGmxbjDBd5NigQ>? NHrkN40zPSEQvF2= NHjlWHozPCCq NG[2ZpFmdmijbnPld{B1cGViYXP0bZZifGmxbjDv[kBRWEGUzsGgZpkhPSEQvF2gdoV{fmW{YYTyc4wtKFR2SGOsJI9zKDRvUFHQ NXP5[IpxOjV5OUi4NlY>
PC12 M3fF[GZ2dmO2aX;uJGF{e2G7 MlPQNlXDqM7:TR?= NXnZemxIPDhiaB?= NVn4TnlL[WO2aY\heIV{KGODTWC= MmfDNlU4Pjl|MEW=
GH3 NITNeG1HfW6ldHnvckBCe3OjeR?= M1zwXVHDqM7:TR?= MW[2MYg> NI\iTVdifHSnboXheIV{KHSqZTDjc5Jz\WyjdHnvckBj\XS5ZXXuJHBTVCCjbnSgRo1idDFiZYjwdoV{e2mxbh?= MXOyOVczPzBzOB?=
GH3 NH;1TZRHfW6ldHnvckBCe3OjeR?= M{njXVHDqM7:TR?= MoHCOk1p M4\aWIlv\HWlZYOgVHJNKGGwZDDCcYFtOSxiYoX0JI5wfCCFbH;jb{whdVKQQTDlfJBz\XO|aX;u NF3LWVUzPTd{N{CxPC=>
BeWo M3\Tc2Z2dmO2aX;uJGF{e2G7 NHfkVmkyOOLCit88UeKh Ml3mO|IhcA>? M1u4dmROW09? NVz0RXFKdWWmaXH0[ZMhSmWZbzDj[YxtKGSrZn\ldoVvfGmjdHnvci=> M4K0bFI2PzF|NEK1
oocytes NWLIdlFCTnWwY4Tpc44hSXO|YYm= Mo\lOUDPxE1? MVOyOEBp Mmq1ZZR1\W63YYTld{BzcC2rboP1cIlvKGGldHnvckBwdiCxb3P5eIUhT1[ERDDzbYdvcW[rY3HueIx6yqB? NGTRU|MzPTdyN{i1OC=>
SC NXzjXnBiTnWwY4Tpc44hSXO|YYm= NFO1dJkxNjVizszN M3nCN|I1KGh? NFy4T4lucW2rY3vzJJRp\SCnZn\lZ5Qhd2ZiY1HNVEBidmGub3fzJI9vKE9zIHHu[EBOSlBiZYjwdoV{e2mxbh?= MkX3NlU4ODV6N{S=
SC NYrhV45HTnWwY4Tpc44hSXO|YYm= MWWwMlUh|ryP M4fqSFczKGh? NVTpPIxPcW6lcnXhd4V{KGKxdHigT5JwgC1{MDDhcoQhVzFiZYjwdoV{e2mxbjDpckBigG:wLYLlcIF1\WRiU1PzJIJ2fCCxbnz5JGtzd3hvMkFCpC=> MUKyOVcxPTh5NB?=
UACC-647  Ml7FSpVv[3Srb36gRZN{[Xl? NXnvUIZ6TE2VTx?= NUjyTJp3dGWjZIOgeI8h[SC{aYPlJIlvKGODTWCgcIV3\Wy|IDjFR|UxyqB;wrCyNE4{QcLizszNLS=> MoriNlU4ODNyMkW=
UACC-647  NGT1[mJHfW6ldHnvckBCe3OjeR?= NY[yemgzOTEEoN88US=> NWHIRYtpOTVibXnu M1HMSWROW09? NHK1SndqdmirYnn0d{BGWkticHjvd5Bpd3K7bHH0bY9v M2DXNVI2PzB|MEK1
UACC-647  M1fDbmZ2dmO2aX;uJGF{e2G7 M2fuTFExyqEQvF2= MoO3NVUhdWmw NEfEO3VFVVOR MXrpcoNz\WG|ZYOg[WVHOiCyaH;zdIhwenmuYYTpc44hdGW4ZXzzxsA> MYWyOVcxOzB{NR?=
SH-SY5Y  NIiye25HfW6ldHnvckBCe3OjeR?= MVWxNOKh|ryP M4S0RlHDqGkEoB?= M2Tte4lv[3KnYYPld{BNXUNiYXP0bZZqfHl? NYmxXmtKOjV3OUe0N|M>
SH-SY5Y  NFnFXJNHfW6ldHnvckBCe3OjeR?= MX2xNOKh|ryP NWTafmo3OcLiaNMg NELIbWVqdmO{ZXHz[ZMhSUeFMTDtVm5CKGyndnXs NGDBfVQzPTV7N{SzNy=>
hADSCs M3npNWZ2dmO2aX;uJGF{e2G7 MkXJOgKBkcL3TR?= NGX6fHE{OCCvaX6= MlzFbY5kemWjc3XzJINCVVBibHX2[Yx{ NHWzWnAzPTV7MUmwPC=>
HEK293  NWXjTYJ3TnWwY4Tpc44hSXO|YYm= NXm2XG06PeLCidM1US=> MkHMN|AhdWmw MoW5bY5kemWjc3XzJINCVVBibHX2[Yx{ NHTNTYkzPTV7MUmwPC=>
3T3-L1 M3r6NmZ2dmO2aX;uJGF{e2G7 NIW3S|gzNjVxNTFOwG0> M3jRdFI1KGkEoB?= NYKwVJV4e2mpbnnmbYNidnSueTDk[YNz\WG|ZYOgRXRIVCCycn;0[YlvKGW6cILld5Nqd25iYYSgZYxtKGSxc3XzJJRme3SnZB?= NVH2VXA6OjV3OUC1PVc>
OCI-Ly1  MkPFSpVv[3Srb36gRZN{[Xl? M1nUTFQxyqEQvF2= NWjtcYJOOcLiaNMg NVrBXHZyTE2VTx?= MmTLbY5lfWOnczD0bIUhcW6lcnXt[Y51KG:oIHPBUXAh[2:wY3XueJJifGmxboO= MlewNlU2PzZ{MkC=
OCI-Ly18  M3HORmZ2dmO2aX;uJGF{e2G7 MknPOFDDqM7:TR?= Mnv3NeKhcMLi NF;1W4RFVVOR NHnU[IFqdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> MmWzNlU2PzZ{MkC=
BeWo MXzGeY5kfGmxbjDBd5NigQ>? NEC2VHgzOMLiwsXN MUO0POKhcA>? MUDEUXNQ MmC0bY5kemWjc3XzJJRp\SCmaX\m[ZJmdnSrYYTpc44hd2ZiQnXXc{Bk\Wyucx?= NIHuc3MzPTV4Nke0NC=>
BeWo NHjkfJdHfW6ldHnvckBCe3OjeR?= MUSyNOKhyrWP M3jOfFQ5yqCq MXHEUXNQ Mn35bY5kemWjc3XzJJRp\SCjZHjld4lwdiCxZjDUTHAuOSCvb37vZ5l1\XN? MYWyOVU3Pjd2MB?=
LNCaP  MYLGeY5kfGmxbjDBd5NigQ>? M1ToSVExyqEQvF2= MlXqNVIhcMLi Mlz2SG1UVw>? MmTXbY5lfWOnczDhJIRz[W2jdHnjJIlv[3KnYYPlJI9nKEOURVKxJIFkfGm4aYT5 NWnLbIJ1OjV3NEiwPVk>
ThGCs  NX\kTYFwTnWwY4Tpc44hSXO|YYm= MlXRNVDjiIsQvF2= NFrBT5E16oDMaB?= MX\heYdu\W62czDITWYySSCuZY\lcJMhfGijdDD3[ZJmKHO2aX31cIF1\WRiYomgR49EdDJ? NFzYWIEzPTR|M{CyOy=>
ThGCs  MWXGeY5kfGmxbjDBd5NigQ>? M3LDPVEx6oDMzszN NHzhVoU16oDMaB?= NGHYcIdqdmO{ZXHz[ZMhS2:FbEKtbY5lfWOnZDDFSG4zyqCpZX7lJIV5eHKnc4Ppc44> MoXmNlU1OzNyMke=
ThGCs  NGHQeJlHfW6ldHnvckBCe3OjeR?= MVmxNQKBks7:TR?= NWrYTpVtOyCq NGmzXolqdmirYnn0d{B1cGViZX\m[YN1KG:oIFiyU|Ihd25iRVTONkBuWk6D MnzENlU1OzNyMke=
RBMECs M4rUU2Z2dmO2aX;uJGF{e2G7 MmDxNE4xPS9yLkWvOUDPxE1? MoHGNE4zPSCq MWjpcoNz\WG|ZYOgZ2FOWCClb37j[Y51emG2aX;u M4PIRlI2PDF4NkWx
RBMECs MUDGeY5kfGmxbjDBd5NigQ>? NI\0SJI2yqEQvF2= MUSxJIg> NUn4W5V7[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> M1XnW|I2PDF4NkWx
RBMECs MXTGeY5kfGmxbjDBd5NigQ>? NU[xOHhPPcLizszN MXqxJIg> MXLwdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> M3TLTFI2PDF4NkWx
RBMECs NXm1emI6TnWwY4Tpc44hSXO|YYm= NXjEV2UzPcLizszN NGjVbFkyKGh? M2nWSJBz\X[nboTzJJRp\SCrbnPy[YF{\SCrbjDIVnAh\my3eDDhZ5Jwe3NidHjlJGJVSiCrbnT1Z4VlKGK7IDDFUWFRNUmL MnnINlU1OTZ4NUG=
RBMECs NYL0RYpxTnWwY4Tpc44hSXO|YYm= Mk\3OeKh|ryP NVPhXJdOOSCq MVfpcohq[mm2czD0bIUh\GWlcnXhd4VlKG:oIHHtc5VvfCCxZjDaU{0yKGmwIF3Gd{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NG[yfFQzPTRzNk[1NS=>
RBMECs MoHrSpVv[3Srb36gRZN{[Xl? M3zW[FXDqM7:TR?= MW[xJIg> NHTzOFhz\X[ncoPld{B1cGViY3jhcodmeyCrbjDaU{0yKGSrc4TybYJ2fGmxbjDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboS= M2jOflI2PDF4NkWx
RBMECs Mm\pSpVv[3Srb36gRZN{[Xl? NVW0Rmo{PcLizszN NX7HT3ZJOSCq M2DjO4Jtd2OtczD0bIUhTU2DUD3JTU1qdmS3Y3XkJINp[W6pZTDpckBOVENicHjvd5Bpd3K7bHH0bY9v Mn7INlU1OTZ4NUG=
RBMECs M{DwZmZ2dmO2aX;uJGF{e2G7 MoXHOeKh|ryP NIDKPFEyKGh? Ml7IZoxw[2u|IITo[UBi[3SrbjDjfZRwe2unbHX0c44hemWjcoLhcodmdWWwdDDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboVCpC=> NUm4NGNSOjV2MU[2OVE>
Primary bovine chondrocytes NISye3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVS3TXNyPc7:TR?= NV\IV|NzPDhiaB?= M1n1UJJmfmW{c3XzJJRp\SCrbnjpZol1d3K7IHXm[oVkfCCxZjDj[Yxm[2:6aXKgc44heHKxbHnm[ZJifGmxbjDpckBoem:5dHigdIxifGViY3jvcoRzd2O7dHXz M3rwPFI2PDB4MEG2
EM1  NELUR4lHfW6ldHnvckBCe3OjeR?= MXmxOgKBks7:TR?= MUO0PEBp NHfkdHZz\WS3Y3XzJJRp\SCneIDy[ZN{cW:wIH;mxsBNUUcEoH;yxsBRXEeVMtMgbY7DqEODTGKtJI9zyqCHUFHDNk1{cWynbnPl[EBGVTFiY3XscJPDqA>? MU[yOVM4QDZ4MR?=
BeWo  NGPRZlRHfW6ldHnvckBCe3OjeR?= MkHBNlDDqML3TR?= NHqwRYc1QMLiaNMg NHj6dYdFVVORwrC= NIGzfZNqdmO{ZXHz[ZMhfGinIHLleIEucEOJIILlcIVie2V? M4nWfFI2OzZ{Mk[w
BeWo  NGjNVYdHfW6ldHnvckBCe3OjeR?= Moj1NlDDqML3TR?= NHT6UJM1QMLiaNMg M1yzS2ROW00EoB?= NYnkdYM5\G:5boLl[5Vt[XSnczD0bIUhdGW4ZXygc4YhXE2HTV[xOi=> NGKxepAzPTN4MkK2NC=>
BeWo  MWDGeY5kfGmxbjDBd5NigQ>? MkD3NlDDqML3TR?= MVG0POKhcMLi MmLmSG1UV8Li NI[xRnlld3ewcnXneYxifGW|IITo[UBt\X[nbDDv[kBIS01vMR?= M2PPUlI2OzZ{Mk[w
granulosa cells NFq0OllHfW6ldHnvckBCe3OjeR?= MYGxNEDPxE1? MUWxNk8zPCCq MlzhbY5kemWjc3XzJJRp\SCuZY\lcJMhd2cEoGLHV|LDqG2UTlG= Mmi3NlU{OzlzMEW=
granulosa cells NGO2SJdHfW6ldHnvckBCe3OjeR?= NXPz[mlpOTBizszN MknFNVIwOjRiaB?= NF:wdHZqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDy[ZBwenSncjDhZ5Rqfmm2eTDmc5IhfGinIHzvcodme3RiZoLh[41mdnRiKPMIllg2PC9tMUjSS3MzNkyXQzm= MkTPNlU{OzlzMEW=
granulosa cells NILVSXVHfW6ldHnvckBCe3OjeR?= MUixNEDPxE1? M2DHUVI1KGh? MV;pcoNz\WG|ZYOgeIhmKGmwdHXud4l1gSCxZjDEUmEweHKxdHXpckBkd22ybHX4 NYX3RYhOOjV|M{mxNFU>
granulosa cells NHTaUXlHfW6ldHnvckBCe3OjeR?= NYD0W4ZGOTBizszN MVOyOEBp NHHWXo1qdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDSS3MzKHC{b33veIVzKGGldHn2bZR6 NVnLWpRDOjV|M{mxNFU>
SK-N-AS  NWP6UlFFS2WubDDWbYFjcWyrdImgRZN{[Xl? MoPiNVAh|ryPwrC= M1H3UVI1NzR6IHi= M4PvbIVvcGGwY3XzJJRqdWVvZHXw[Y5l\W62bImgZ4VtdHWuYYKgeoli[mmuaYT5xsA> NHzxOXQzPTJ4NkC2Ny=>
SK-N-AS  MkXTSpVv[3Srb36gRZN{[Xl? M4nl[|ExKM7:TdMg NIi1SGIzPCCq MUnpcoNz\WG|ZYOgeIhmKGODTWCgcIV3\Wy|wrC= MWOyOVI3PjB4Mx?=
SK-N-AS  NV\memwyTnWwY4Tpc44hSXO|YYm= M{LkZ|ExKM7:TdMg MmryNlQhcA>? MlnVbY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIH;mJIN6[2yrbjDENS=> MmWxNlUzPjZyNkO=
SK-N-AS  Mmn4SpVv[3Srb36gRZN{[Xl? NHe1TXAyOCEQvF5CpC=> NFjxepE{OCCvaX6= NGrUcI1qdmS3Y3XzJJBpd3OyaH;yfYxifGmxbjDv[kDPui2lYYTlcolvKCi|ZYK2O|UqNCCyLVfTT|PPuiBqc3XyPUkh[W6mIHPvcoNwdWm2YX70JIhq\2incjDs[ZZmdHNib3[gZYN1cX[nLDD1cpBpd3OyaH;yfYxifGWmLDFOtk1k[XSnbnnu MnTaNlUzPjZyNkO=
SK-N-AS  NX\r[GhDTnWwY4Tpc44hSXO|YYm= MVGxNEDPxE4EoB?= NVflO5JpOTBxM{CvOlAhdWmw MWPpcoNz\WG|ZYOgcIV3\Wy|IH;mJJAu|rJvY3H0[Y5qdiBqc3XyOlc2MSCjbnSgbY5lfWOnczDhZ4N2dXWuYYTpc44hd2ZicD5Otk1k[XSnbnnuJEh{\XJ4N{WpJIlvKCiyZYLpLY52[2ynYYKgdoVocW:wcx?= MnvBNlUzPjZyNkO=
SK-N-SH M{P1O2NmdGxiVnnhZoltcXS7IFHzd4F6 NHW0[JAyOCEQvF5CpC=> MXy0PEBp NYfpfo57\W6qYX7j[ZMhW0tvTj3TTEBv\XW{b3LsZZN1d22jIHPlcIwhfmmjYnnsbZR6 NYL4TZRtOjV{Nk[wOlM>
HEK‐CFTR NIfzN45HfW6ldHnvckBCe3OjeR?= M{LqRVLjiJN3MNMg{txO M{HvRVAuOTJibXnu M1GxSGROW00EoB?= Ml62bY5lfWOnczDhJIRwe2YkgKDk[ZBmdmSnboSgbY9lcWSnIHXm[ox2gMLi M3Po[VI2OjZ|MkC3
L6 M4rZeWZ2dmO2aX;uJGF{e2G7 NXLtfIlGPDBiwsXN NFX1clUzPCCq NFjyenlqdmirYnn0d{BFVUhzLXnu[JVk\WRiQXv0JIFkfGm4YYTpc44> NYn4XpF3OjV{NEe1OVA>
MIN6  NV7KTHNGTnWwY4Tpc44hSXO|YYm= M2XBVVExKM7:TdMg NGHLSVQ{KGh? MmXSbY5kemWjc3XzJGQ{KG2UTlGg[ZhxemW|c3nvci=> NFXZbHQzPTJ2MUGyOC=>
ventricular cardiomyocytes  NFXuTGVHfW6ldHnvckBCe3OjeR?= MnfFNE4xOS1zMDFOwG0> NGfLNVNqdmO{ZXHz[ZMhKGODTWCgZYNkfW23bHH0bY9v NILXWIczPTJyM{GxNy=>
ventricular cardiomyocytes  M{H3NGZ2dmO2aX;uJGF{e2G7 NUW2OYpUOC5yMT2xNEDPxE1? NY\6dFlL\X[xa3XzJIFvKGmwb4Tyc5Bq[yC{ZYPwc45{\SBzMkFCtVE2LSCjYn;2[UBj[XOjbDD3bZRpKGGwIFXDOVDDqG:oIEKuNkDDvU1? NF3JWFgzPTJyM{GxNy=>
BeWo  M3Ts[mZ2dmO2aX;uJGF{e2G7 NXfoSXV4OjBiwsXN NIjvdI01QCCq NELWfWRFVVORwrC= NWTVUHBycW6mdXPld{Bk\WyuIH\1d4lwdg>? MoHCNlUyQDR2N{e=
THP-1  MVnGeY5kfGmxbjDBd5NigQ>? MVGxM|ExKM7:TR?= NELEXXczyqCq NFfpdphFVVORwrC= MnL5d5VxeHKnc4Pld{BOS1BvMTDwdo9lfWO2aX;uxsA> MV[yOVE2PDh6Mh?=
Huh-7 NIS5UpJHfW6ldHnvckBCe3OjeR?= NHjFSHgxNTJyIN88US=> MmfGNkBpyqB? NEjLZ|dz\XO3bITzJIlvKGFiZH;z[U1l\XCnbnTlcpQhcW6lcnXhd4UhcW5iYz3NfYMh\XiycnXzd4lwdiCjdDD0bIUheHKxdHXpckBidmRibWLORUBt\X[nbIO= Mn;0NlUyODl6M{S=
C6 MlvnSpVv[3Srb36gRZN{[Xl? MlHGNVAh|ryPwrC= NGHkbnYzOCCvaX6= MVHpcoNz\WG|ZYOgZ2FOWCCjY3P1cZVt[XSrb36= NUfNUYRROjVyNkm0NVc>
SW480 Mn3OSpVv[3Srb36gRZN{[Xl? NXLZVG9iPDEEoN88US=> MWe0POKhcA>? MVPEUXNQ MXjhZ5RqfmG2ZYOgVHAzSQ>? MXmyOFk6PzR3MR?=
HT-29  MWDGeY5kfGmxbjDBd5NigQ>? MnPROFDDqM7:TR?= MUW0POKhcA>? MWHEUXNQ MojDZYN1cX[jdHXzJHBROkF? M{fHT|I1QTl5NEWx
SW480 M4PvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkWxOFDDqM7:TR?= MV[wMVczKGh? MnPQSG1UVw>? MkLhbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> M3nvWFI1QTl5NEWx
HT-29  M1zONmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXm0NOKh|ryP NHvZcosxNTd{IHi= MlO4SG1UVw>? MWjpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nIHTldIVv\GWwdHz5 M1HDdFI1QTl5NEWx
SW480 MWHGeY5kfGmxbjDBd5NigQ>? NYLTU205PDEEoN88US=> NV;Y[oVPPyCm NH6wO5lFVVOR MUfy[YR2[2W|IHPvcI9vd3OyaHXy[UBnd3KvYYTpc44h[2GyYXLpcIl1gcLi Moj1NlQ6QTd2NUG=
HT-29  MkPMSpVv[3Srb36gRZN{[Xl? NFnIfHU1OMLizszN NX7tRnQ3PyCm NH74d|NFVVOR M2fTXZJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= NIPIdWYzPDl7N{S1NS=>
SW480 M4TYemFxd3C2b4Ppd{BCe3OjeR?= MnjQOFDDqM7:TR?= NVHoRWlxPDkEoHi= MlrxSG1UVw>? MkXIbY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 MkHhNlQ6QTd2NUG=
HT-29  MUDBdI9xfG:|aYOgRZN{[Xl? NGDtZ5g1OMLizszN MW[0POKhcA>? Mo\qSG1UVw>? NVTp[JNpcW6mdXPld{BidiCjY4TpeoF1cW:wIH;mJINie3Cjc3WgN{84 M4[4S|I1QTl5NEWx
SW480 MW\BdI9xfG:|aYOgRZN{[Xl? M2TFfFQxyqEQvF2= MXq0POKhcA>? MV3EUXNQ NF7VNnhqdmS3Y3XzJINp[W6pZYOgbY4hfGinIIDoc5NxcG:{eXzheIlwdiC|dHH0eZMhd2ZiUGCyRUB1[XKpZYTz MUeyOFk6PzR3MR?=
HT-29  NF71PYFCeG:ydH;zbZMhSXO|YYm= NXvhZpIyPDEEoN88US=> NY\wT4FUPDkEoHi= NUDCNHFiTE2VTx?= NUnRXI5jcW6mdXPld{BkcGGwZ3XzJIlvKHSqZTDwbI9{eGixconsZZRqd25ic4TheJV{KG:oIGDQNmEhfGG{Z3X0dy=> Mnz1NlQ6QTd2NUG=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
in solvent
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null Not Applicable
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID