Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MX3GeY5kfGmxbjDBd5NigQ>? MXOxNEDPxE1? MkHROkBp Mo\nbY5kemWjc3XzJJBpd3OyaH;yfYxifGmxbjDv[kBwfmW{ZYjwdoV{e2WmIFvMTGw{KGG2IGO0N|M> MlHjNlY1OzV2OUi=
Mo-DCs MWjGeY5kfGmxbjDBd5NigQ>? MUC1NEDPxE1? MVqyOQKBkWh? NUezZXo1eHKxbX;0[ZMhUUxvMkOgdJJw\HWldHnvckBqdiC2aHWgd5Vx\XKwYYThcpQhd2Zieontc5NidiC|dHnteYxifGWmIF3vMWREe8Li M3rHZlI3PDF{OUS4
RBMECs  NITHUZFHfW6ldHnvckBCe3OjeR?= MnHZOeKh|ryP NFPMO3QyyqCq NEXnUmdjdG:la4OgeIhmKFKjY{GgbY5i[3SrdnH0bY9vKGmwZIXj[YQh[nliRV3BVE1KUQ>? M2HSVlI3OzV6MEO5
INA-6 MnP5R4VtdCCYaXHibYxqfHliQYPzZZk> Mn3RNE0yODBizszN M13Se|cz6oDLaB?= MXvpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= NHnqNmkzPjNyNk[yOC=>
OPM-2 MX7D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFjUfJIxNTFyMDFOwG0> M13nR|cz6oDLaB?= NHXB[JNqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> M1fmclI3OzB4NkK0
U266 Mnu1R4VtdCCYaXHibYxqfHliQYPzZZk> NGnTXVExNTFyMDFOwG0> NF\sZW04OuLCiXi= M2jCOIlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 NGHIZoQzPjNyNk[yOC=>
H929 NH7tdZdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MnTNNE0yODBizszN M1jGflcz6oDLaB?= NFzx[ldqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> NUnlW4VxOjZ|ME[2NlQ>
RPMI 8226 NVflVYxoS2WubDDWbYFjcWyrdImgRZN{[Xl? NFfye40xNTFyMDFOwG0> MmPGO|LjiImq NEWzdGJqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> NX\Zb|hsOjZ|ME[2NlQ>
MDCK  MoPpSpVv[3Srb36gRZN{[Xl? M3PzSFExKML3TR?= M3;3dVI1KGh? NX3DfWd3TE2VTx?= NVPkUYkyfXC{ZXf1cIF1\XNidHjlJIV5eHKnc4Ppc44hd2ZiVFfGMe6zOSCjbnSgR3RITsLi NF2wNZAzPjJyMkO1Ni=>
MDCK  MmHySpVv[3Srb36gRZN{[Xl? NV3MOo91OTBiwsXN NX\1U4RCOjRiaB?= NFewVnVFVVOR MVjpcohq[mm2czD0bIUhcW6lcnXhd4VlKGW6cILld5Nqd25ib3[gSm4h[2G3c3XkJIJ6KFSJRj5OtlE> M17HS|I3OjB{M{Wy
Spinal cords  NV7FbI9oTnWwY4Tpc44hSXO|YYm= NUC0cW4zOcLizszN MX2zNEBucW5? Mlfnd5RqdXWuYYTld{BkSU2SIHzleoVtew>? MnK3NlYyOjZ7Mk[=
BeWo  MoXrSpVv[3Srb36gRZN{[Xl? MWKyOgKBkc7:TR?= MoHNNlQwPDhxN{KgbC=> MUjs[YFleyC2bzDhckBqdmO{ZXHz[UBqdiC2aHWg[ZhxemW|c3nvckBw\iCxdHjldkBnfXOrb36gcYFzc2W{cx?= MoT1NlYxPTN3NEm=
bovine oocytes M{LYTmZ2dmO2aX;uJGF{e2G7 NXzzT4xVOTBywrFOwG0> NX3Ld3ZOOTMEoHi= NVLtfIFUcW6qaXLpeJMhfGinIHXm[oVkfCCxZjDOVHBCKGGwZD;vdkBPWFCFIITvJJN1cW23bHH0[UBz\XO3bYD0bY9vKG:oIH3lbY9{cXN? NYP4RoVFOjZyNUG2NVE>
Caco-2  Ml3aSpVv[3Srb36gRZN{[Xl? MXiwMlEwOS9zMDFOwG0> NV7MW3FROjEEoH3pci=> M3\4UIlv\HWlZYOgZUBld3OnLXTldIVv\GWwdDDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IHPBUXAhdGW4ZXzz NYHUOoZ2OjZyNEmxNFI>
Caco-2  Mlj6SpVv[3Srb36gRZN{[Xl? NVPYXYVvOC5zL{GvNVAh|ryP NEn2W40zPCCq MXHpcoNz\WG|ZYOgUXJROiCycn;0[YlvKGyndnXs M2TtSVI3ODR7MUCy
AML-12  M4rQWmZ2dmO2aX;uJGF{e2G7 NIfNVW0zOCEQvF2= NEHLeoM{KGh? MV\1dJJm\3WuYYTld{B1cGVicHjvd5Bpd3K7bHH0bY9vKGyndnXsd{BifCCWaIKtOFEyKGGwZDDT[ZIuPDl| NFi2Z2MzPjB2OEm4OS=>
AML-12  NE\LfoNHfW6ldHnvckBCe3OjeR?= MmjzNlAh|ryP MX2xMVghcA>? M4Prd4lv[3KnYYPld{BodHWlb4PlJJBzd2S3Y4Tpc44> M4\US|I3ODR6OUi1
AML-12  MmnoSpVv[3Srb36gRZN{[Xl? MkDhNlAh|ryP NH3ocpo{KGh? M3f5T5VxNXKnZ4XsZZRme8LiUHfjNYEtyqCSZYDjb{wh[W6mwrDHOpBkyqCvUl7BJIxmfmWucx?= NYfSVHg2OjZyNEi5PFU>
AML-12  NEO1cnNHfW6ldHnvckBCe3OjeR?= M1HqflIxKM7:TR?= MWCzJIg> MVzpcoR2[2W|IITo[UBl\XCqb4PwbI9zgWyjdHnvckBw\iCFUmTDNuKh M3vGRVI3ODR6OUi1
RBMECs NGrYbpBHfW6ldHnvckBCe3OjeR?= MnXiOeKh|ryP MVuxJIg> MnrhbY5pcWKrdIOgSW1CWC2LST3pcoR2[2WmIHnuZYN1cX[jdHnvckBw\iCUYYCxxsA> NXjOVG1EOjZyNES2OlM>
EndoC-βH1 NX[5V5VlTnWwY4Tpc44hSXO|YYm= NEX4c2Q2yqEQvF2= NGq5XWsyKGh? NXLDbm8xeG:2ZX70bYF1\XNiZ3z1Z49{\S2rbnT1Z4VlKGmwc4XsbY4he2WlcnX0bY9vKGmwIITo[UBxemW|ZX7j[UBw\iCpbIXjc5Nm MXyyOlAzQDV4Mh?=
EndoC-βH1 M{\6bWZ2dmO2aX;uJGF{e2G7 NET6dGE2yqEQvF2= MYSxJIg> NWj0XFNNdGWjZIOgeI8h[SC|dILvcoch[0GPUDDpcoNz\WG|ZR?= MUWyOlAzQDV4Mh?=
SH-SY5Y NIL1XIxHfW6ldHnvckBCe3OjeR?= NVS3THdPOzBizszN NV36c|ZLOzBibXnu NVTjVHA1TE2VTx?= MUHzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgZYN1cX[jdHnvckBw\iCSS1G= NFfIfIozPjB{NUGzOy=>
PC-3 NXfoWIhRTnWwY4Tpc44hSXO|YYm= Mn:0OFAhyrWP NEnXUoIzKGh? NHLlRXdFVVOR M1LsWoxm[WS|IITvJHBROkFiYXP0bZZifGmxbh?= M4XGWlI3ODJ|OEO2
PC-3 NXvoUHNMS2WubDDWbYFjcWyrdImgRZN{[Xl? M3v2OFQxKML3TR?= NWjCV3ozOjRxNEivO|IhcA>? NGr6PZFFVVOR NXS4eoFS\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJRqdWViZHXw[Y5l\W62bIm= MlvvNlYxOjN6M{[=
SCG NXrjPJZrTnWwY4Tpc44hSXO|YYm= NW\hco85OjBizszNxsA> NVvK[|ExTE2VTx?= MkTOdoV3\XK|aXLsfUB{fXCycnXzd4V{KEmNVjD3bZRpKGFiSVO1NEBw\iB{ND60JO69VQ>? MnXMNlU6PjJzM{K=
HEK-293 M4K3OWZ2dmO2aX;uJGF{e2G7 MlfVN|Uh|ryPwrC= NILoc21FVVOR NWSwWpFXcW6mdXPld{BiKGOxboPwbYN2d3W|IPMAoIlv[WO2aY\heIlwduLCnTDv[kB1cGViS4[yMlEh[3W{cnXueC=> NVOyeoMzOjV7NkKxN|I>
SCG M3\6RmZ2dmO2aX;uJGF{e2G7 NFvqPIIyODBizszNxsA> NELneoxFVVOR NFXMPHFz\WS3Y3XzJJRp\SCneHPpeIFjcWyrdImgc4YhW0OJIH7leZJwdnN? NYHjcYJrOjV7NkKxN|I>
PCCL3 MYXGeY5kfGmxbjDBd5NigQ>? M2SzZVExKML3TR?= NIDoRVQzPCCq NE\5S49mdmijbnPld{BFfU:6MjDwdo9ud3SncjD0doFve2O{aYD0bY9vKGGldHn2bZR6yqEkgJu= NH24VpczPTl4MEm1Oi=>
3T3-L1 preadipocytes Ml23SpVv[3Srb36gRZN{[Xl? NGXWOHAyOCEQvF5CpC=> MnH0NVIhcA>? NInvXJRqdmS3Y3XzJGNTTUJicHjvd5Bpd3K7bHH0bY9vKGGwZDDDM2VDWM7{IHX4dJJme3Orb36= MojqNlU6OjhyNUi=
H295R  MXTGeY5kfGmxbjDBd5NigQ>? NH:zblIyOMLizszN M4\pc|Q5yqCq Mli4bY5kemWjc3XzJJN1\XKxaXSgcYV1[WKxbHn0[ZMhcW5idHjlJIFv\HKxZ3XuMEBucW6ncnHsc{0h[W6mIHfseYNw[2:{dHnjc4llKHCjdHj3ZZl{ NUjtTmFDOjV6Nkm1OVY>
PBMC NUDXeWxCTnWwY4Tpc44hSXO|YYm= M3jWdlUxyqEQvF2= NFm4WIkzPMLiaNMg NWmwXmNpcW6qaXLpeJMhfGinIHnuZ5Jm[XOnZDDz[YNz\XSrb36gc4YhXE6IIHnu[JVk\WRiYomgeIhmKESSRR?= M2nDe|I2QDZ4MEe5
GLUTag  MlTBSpVv[3Srb36gRZN{[Xl? M1vOO|Ex6oDLwsXN MoWzNE8zNzRiaB?= MWfzeIlufWyjdHXzJGdNWC1zIIPlZ5JmfGmxbjDjc5Rz\WG2ZXSge4l1cCCLQl3Y M{HzRlI2QDN{NkOx
GLUTag  MYHGeY5kfGmxbjDBd5NigQ>? M1S4PVEx6oDLwsXN M3u1ZVQhcA>? Mo\abY5kemWjc3XzJJRp\SCyQ2LFRkBt\X[nbIOge4l1cCC2aHWgTWJOYA>? MYiyOVg{OjZ|MR?=
BAECs MlXlSpVv[3Srb36gRZN{[Xl? NF3KVHQzPSEQvF2= MV2yOEBp NUnSVHd3\W6qYX7j[ZMhfGinIHHjeIl3[XSrb36gc4YhWFCDUt8xJIJ6KDVizszNJJJme3[ncnH0do9tNCCWNFjTMEBweiB2LWDBVC=> NH;FTWQzPTd7OEiyOi=>
PC12 MoKxSpVv[3Srb36gRZN{[Xl? MVmyOeKh|ryP NHfSUmk1QCCq MmPwZYN1cX[jdHXzJINCVVB? MV:yOVc3QTNyNR?=
GH3 Mlq3SpVv[3Srb36gRZN{[Xl? NHHuT|MyyqEQvF2= NVPm[ZZYPi2q NEDWOZBifHSnboXheIV{KHSqZTDjc5Jz\WyjdHnvckBj\XS5ZXXuJHBTVCCjbnSgRo1idDFiZYjwdoV{e2mxbh?= NXrO[WR1OjV5MkewNVg>
GH3 NWDifIc{TnWwY4Tpc44hSXO|YYm= NH;se4oyyqEQvF2= M{ixUVYucA>? M3\5S4lv\HWlZYOgVHJNKGGwZDDCcYFtOSxiYoX0JI5wfCCFbH;jb{whdVKQQTDlfJBz\XO|aX;u MUWyOVczPzBzOB?=
BeWo NIHteZpHfW6ldHnvckBCe3OjeR?= NFvpfmsyOOLCit88UeKh MoLyO|IhcA>? M3K1[GROW09? NX7l[pVQdWWmaXH0[ZMhSmWZbzDj[YxtKGSrZn\ldoVvfGmjdHnvci=> MmKwNlU4OTN2MkW=
oocytes NGfUUHhHfW6ldHnvckBCe3OjeR?= NFS0VG42KM7:TR?= M1nCfFI1KGh? NHPEeZlifHSnboXheIV{KHKqLXnud5VtcW5iYXP0bY9vKG:wIH;vZ5l1\SCJVlLEJJNq\26rZnnjZY51dHoEoB?= MXSyOVcxPzh3NB?=
SC NWrINJdFTnWwY4Tpc44hSXO|YYm= MkjvNE42KM7:TR?= M3:yXFI1KGh? M3PzfY1qdWmla4OgeIhmKGWoZnXjeEBw\iClQV3QJIFv[WyxZ4Ogc44hVzFiYX7kJG1DWCCneIDy[ZN{cW:w NWq5UYxuOjV5MEW4O|Q>
SC MXnGeY5kfGmxbjDBd5NigQ>? MUOwMlUh|ryP NHfheFg4OiCq M4jyOIlv[3KnYYPld{Bjd3SqIFvyc5guOjBiYX7kJG8yKGW6cILld5Nqd25iaX6gZZhwdi2{ZXzheIVlKFOFczDieZQhd26ueTDLdo95NTJywrC= NGn5NoMzPTdyNUi3OC=>
UACC-647  Mom5SpVv[3Srb36gRZN{[Xl? NETUdW9FVVOR M3f1Toxm[WS|IITvJIEhemm|ZTDpckBkSU2SIHzleoVteyBqRVO1NOKhRcLiMkCuN|nDqM7:TTm= M1zKUFI2PzB|MEK1
UACC-647  M{HKUWZ2dmO2aX;uJGF{e2G7 NH;ZWWYyOMLizszN NFzYdFcyPSCvaX6= NUjmVYh7TE2VTx?= Ml[3bY5pcWKrdIOgSXJMKHCqb4PwbI9zgWyjdHnvci=> NUjSTIpZOjV5MEOwNlU>
UACC-647  MVPGeY5kfGmxbjDBd5NigQ>? MUSxNOKh|ryP NHrFdJEyPSCvaX6= NXLXOWhbTE2VTx?= NXvDWItscW6lcnXhd4V{KGWHRkKgdIhwe3Cqb4L5cIF1cW:wIHzleoVte8Li MXeyOVcxOzB{NR?=
SH-SY5Y  NXXSTGxtTnWwY4Tpc44hSXO|YYm= MknNNVDDqM7:TR?= M3e3TVHDqGkEoB?= MWnpcoNz\WG|ZYOgUHVEKGGldHn2bZR6 NWrtUY92OjV3OUe0N|M>
SH-SY5Y  MXLGeY5kfGmxbjDBd5NigQ>? M4[4clExyqEQvF2= MVWxxsBpyqB? NVrBSlZicW6lcnXhd4V{KEGJQ{GgcXJPSSCuZY\lcC=> MVOyOVU6PzR|Mx?=
hADSCs NU\BW3FuTnWwY4Tpc44hSXO|YYm= MWm15qCKyrWP NE\X[GE{OCCvaX6= NHHxOpNqdmO{ZXHz[ZMh[0GPUDDs[ZZmdHN? MXWyOVU6OTlyOB?=
HEK293  MYjGeY5kfGmxbjDBd5NigQ>? MoTHOgKBkcL3TR?= MWSzNEBucW5? MVPpcoNz\WG|ZYOgZ2FOWCCuZY\lcJM> MlLBNlU2QTF7MEi=
3T3-L1 MmDmSpVv[3Srb36gRZN{[Xl? NH7WZlgzNjVxNTFOwG0> NXHWOlIyOjRiaNMg NHe0coV{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnczDBWGdNKHC{b4TlbY4h\XiycnXzd4lwdiCjdDDhcIwh\G:|ZYOgeIV{fGWm NEnIOW8zPTV7MEW5Oy=>
OCI-Ly1  NI[3T49HfW6ldHnvckBCe3OjeR?= MkDaOFDDqM7:TR?= MVKxxsBpyqB? M{G4N2ROW09? M37y[4lv\HWlZYOgeIhmKGmwY4LlcYVvfCCxZjDjRW1RKGOxbnPlcpRz[XSrb37z Mo\pNlU2PzZ{MkC=
OCI-Ly18  M2rwRmZ2dmO2aX;uJGF{e2G7 NYKwc4JnPDEEoN88US=> M2[1c|HDqGkEoB?= MnjoSG1UVw>? NXq0[XBPcW6mdXPld{B1cGViaX7jdoVu\W62IH;mJINCVVBiY3;uZ4VvfHKjdHnvcpM> M{i0eFI2PTd4MkKw
BeWo M3e4T2Z2dmO2aX;uJGF{e2G7 NXfpWY54OjEEoNM1US=> MWO0POKhcA>? MnvTSG1UVw>? MVjpcoNz\WG|ZYOgeIhmKGSrZn\ldoVvfGmjdHnvckBw\iCEZWfvJINmdGy| M2K0clI2PTZ4N{Sw
BeWo NEHpeIZHfW6ldHnvckBCe3OjeR?= M{LSTlIxyqEEtV2= NYfIWWNpPDkEoHi= MV\EUXNQ MWLpcoNz\WG|ZYOgeIhmKGGmaHXzbY9vKG:oIGTIVE0yKG2xbn;jfZRmew>? MXeyOVU3Pjd2MB?=
LNCaP  NUnjVVNKTnWwY4Tpc44hSXO|YYm= MorUNVDDqM7:TR?= NH;DeWYyOiCqwrC= NF7xb|ZFVVOR NVHiPZVGcW6mdXPld{BiKGS{YX3heIlkKGmwY4LlZZNmKG:oIFPSSWIyKGGldHn2bZR6 M37pXlI2PTR6MEm5
ThGCs  MorpSpVv[3Srb36gRZN{[Xl? MWKxNQKBks7:TR?= MWK05qCLcA>? MYrheYdu\W62czDITWYySSCuZY\lcJMhfGijdDD3[ZJmKHO2aX31cIF1\WRiYomgR49EdDJ? NFexfFkzPTR|M{CyOy=>
ThGCs  NVq1fmtUTnWwY4Tpc44hSXO|YYm= M4nLd|Ex6oDMzszN MVu05qCLcA>? MlLpbY5kemWjc3XzJGNwS2x{LXnu[JVk\WRiRVTONuKh\2WwZTDlfJBz\XO|aX;u Mlq0NlU1OzNyMke=
ThGCs  MWnGeY5kfGmxbjDBd5NigQ>? M1nWfFEx6oDMzszN NIfIcoY{KGh? NVHSeoY4cW6qaXLpeJMhfGinIHXm[oVkfCCxZjDINm8zKG:wIFXEUlIhdVKQQR?= NGC2R4UzPTR|M{CyOy=>
RBMECs MmezSpVv[3Srb36gRZN{[Xl? MYGwMlA2NzBwNT:1JO69VQ>? MmDzNE4zPSCq NVuzVHlXcW6lcnXhd4V{KGODTWCgZ49v[2WwdILheIlwdg>? MVOyOVQyPjZ3MR?=
RBMECs NUfLRoU2TnWwY4Tpc44hSXO|YYm= MkTUOeKh|ryP NX;rXoo{OSCq MX;icI9kc3NidHjlJIFkfGm4YYTpc44hd2ZiUnjvRU9TV0ONIHnu[JVk\WRiYomgSW1CWC2LSR?= M3HSUlI2PDF4NkWx
RBMECs MXrGeY5kfGmxbjDBd5NigQ>? MnrwOeKh|ryP MVqxJIg> NH7qSZlxemW4ZX70d{B1cGViRV3BVE1KUS2rbnT1Z4VlKFSHRWKgeoFtfWViZHXjdoVie2V? NGrNZYYzPTRzNk[1NS=>
RBMECs NUDCPHBlTnWwY4Tpc44hSXO|YYm= Mo\SOeKh|ryP MUOxJIg> NGjUdG5xemW4ZX70d{B1cGViaX7jdoVie2ViaX6gTHJRKG[udYigZYNzd3O|IITo[UBDXEJiaX7keYNm\CCkeTCgSW1CWC2LSR?= M2XwblI2PDF4NkWx
RBMECs NVHkbFJJTnWwY4Tpc44hSXO|YYm= NVH3UYN4PcLizszN NF3FVIIyKGh? NWnRfnVocW6qaXLpeJMhfGinIHTlZ5Jm[XOnZDDv[kBidW:3boSgc4YhYk9vMTDpckBOTnNiaX7keYNm\CCkeTDFUWFRNUmL MnP4NlU1OTZ4NUG=
RBMECs NXPEepFvTnWwY4Tpc44hSXO|YYm= Mne4OeKh|ryP NELQSIoyKGh? NYr6dYw{emW4ZYLz[ZMhfGinIHPoZY5o\XNiaX6gXm8uOSCmaYP0doljfXSrb36gd4VmdiC5aYToJGVOSVBvSVmgeJJm[XSvZX70 NHjFeGEzPTRzNk[1NS=>
RBMECs M13zemZ2dmO2aX;uJGF{e2G7 Ml\sOeKh|ryP M2f2VlEhcA>? Mom5Zoxw[2u|IITo[UBGVUGSLVnJMYlv\HWlZXSgZ4hidmenIHnuJG1NSyCyaH;zdIhwenmuYYTpc44> M1HNU|I2PDF4NkWx
RBMECs Mme2SpVv[3Srb36gRZN{[Xl? NFXITlI2yqEQvF2= MYOxJIg> NVjydlR5[myxY3vzJJRp\SCjY4TpckBkgXSxc3vlcIV1d25icnXhdpJidmenbXXueEB{\WWwIIfpeIghTU2DUD3JTUB1emWjdH3lcpTDqA>? NHXwe3YzPTRzNk[1NS=>
Primary bovine chondrocytes Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m2VVXPxE1? NVvrbHBtPDhiaB?= Mn7UdoV3\XK|ZYOgeIhmKGmwaHnibZRwenliZX\m[YN1KG:oIHPlcIVkd3irYjDvckBxem:uaX\ldoF1cW:wIHnuJIdzd3e2aDDwcIF1\SClaH;u[JJw[3m2ZYO= NUnFc|JZOjV2ME[wNVY>
EM1  NYrvNZZbTnWwY4Tpc44hSXO|YYm= MmG2NVXjiIsQvF2= NHjKN|A1QCCq NWHmV|hmemWmdXPld{B1cGViZYjwdoV{e2mxbjDv[uKhVEmIwrDvduKhWFSJU{NCpIlvyqCFQVzSMUBwesLiRWDBR|Iue2muZX7j[YQhTU1zIHPlcIx{yqB? NHHsUHIzPTN5OE[2NS=>
BeWo  NXzBTJozTnWwY4Tpc44hSXO|YYm= NYPqcoMyOjEEoNM1US=> NU\zTnhEPDkEoHlCpC=> Mom4SG1UV8Li MYTpcoNz\WG|ZYOgeIhmKGKndHGtbGNIKHKnbHXhd4U> NGqyNHAzPTN4MkK2NC=>
BeWo  Mn74SpVv[3Srb36gRZN{[Xl? MkPjNlDDqML3TR?= M2niVlQ5yqCqwrC= NUXSdm5ITE2VT9Mg M{LDfIRwf26{ZXf1cIF1\XNidHjlJIxmfmWuIH;mJHROTU2IMU[= MYiyOVM3OjJ4MB?=
BeWo  NWHYTWxNTnWwY4Tpc44hSXO|YYm= MoPDNlDDqML3TR?= NVPHOnVzPDkEoHlCpC=> M3\ldGROW00EoB?= Ml33[I94dnKnZ4XsZZRmeyC2aHWgcIV3\Wxib3[gS2NONTF? NVPPeppnOjV|NkKyOlA>
granulosa cells NVnuOFFZTnWwY4Tpc44hSXO|YYm= MWexNEDPxE1? MYqxNk8zPCCq MWTpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\sLiUlfTNuKhdVKQQR?= NGPITmMzPTN|OUGwOS=>
granulosa cells NITidlhHfW6ldHnvckBCe3OjeR?= MX6xNEDPxE1? NFHzdokyOi9{NDDo NIHsV5hqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDy[ZBwenSncjDhZ5Rqfmm2eTDmc5IhfGinIHzvcodme3RiZoLh[41mdnRiKPMIllg2PC9tMUjSS3MzNkyXQzm= M1vSV|I2OzN7MUC1
granulosa cells NHi5[npHfW6ldHnvckBCe3OjeR?= NUXsXXFCOTBizszN MkjxNlQhcA>? MVjpcoNz\WG|ZYOgeIhmKGmwdHXud4l1gSCxZjDEUmEweHKxdHXpckBkd22ybHX4 MkDyNlU{OzlzMEW=
granulosa cells MVPGeY5kfGmxbjDBd5NigQ>? M1PlT|ExKM7:TR?= MkPNNlQhcA>? NHjPSYFqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDSS3MzKHC{b33veIVzKGGldHn2bZR6 MmjMNlU{OzlzMEW=
SK-N-AS  M{D1TmNmdGxiVnnhZoltcXS7IFHzd4F6 Mmr1NVAh|ryPwrC= M3rJSVI1NzR6IHi= NHy0boxmdmijbnPld{B1cW2nLXTldIVv\GWwdHz5JINmdGy3bHHyJJZq[WKrbHn0feKh M3PFRlI2OjZ4ME[z
SK-N-AS  NYrDN4F5TnWwY4Tpc44hSXO|YYm= NXfwbZN5OTBizszNxsA> NETNdGszPCCq NVLOSlhvcW6lcnXhd4V{KHSqZTDjRW1RKGyndnXsd:Kh MU[yOVI3PjB4Mx?=
SK-N-AS  M1LDV2Z2dmO2aX;uJGF{e2G7 MUSxNEDPxE4EoB?= MW[yOEBp MnK3bY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIH;mJIN6[2yrbjDENS=> NHrOeVQzPTJ4NkC2Ny=>
SK-N-AS  NUXOUXF7TnWwY4Tpc44hSXO|YYm= MU[xNEDPxE4EoB?= NHnnTYE{OCCvaX6= M2XtbIlv\HWlZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJO6zNWOjdHXubY4hMHOnck[3OUktKHBvR2PLN:6zKCi|ZYK5LUBidmRiY3;uZ49ucXSjboSgbIlocGW{IHzleoVteyCxZjDhZ5RqfmVuIIXudIhwe3Cqb4L5cIF1\WRuIN8yMYNifGWwaX6= MnLFNlUzPjZyNkO=
SK-N-AS  MoXRSpVv[3Srb36gRZN{[Xl? M4[3XFExKM7:TdMg MY[xNE8{OC94MDDtbY4> MX3pcoNz\WG|ZYOgcIV3\Wy|IH;mJJAu|rJvY3H0[Y5qdiBqc3XyOlc2MSCjbnSgbY5lfWOnczDhZ4N2dXWuYYTpc44hd2ZicD5Otk1k[XSnbnnuJEh{\XJ4N{WpJIlvKCiyZYLpLY52[2ynYYKgdoVocW:wcx?= MWqyOVI3PjB4Mx?=
SK-N-SH MljtR4VtdCCYaXHibYxqfHliQYPzZZk> M2nDeVExKM7:TdMg Mm\kOFghcA>? NELZNpRmdmijbnPld{BUUy2QLWPIJI5mfXKxYnzhd5RwdWFiY3XscEB3cWGkaXzpeJk> MlvrNlUzPjZyNkO=
HEK‐CFTR MWDGeY5kfGmxbjDBd5NigQ>? NF[4b5Ez6oDVNUFCpO69VQ>? NWX0XlJ5OC1zMjDtbY4> NYqwSGZuTE2VT9Mg NX74dVFNcW6mdXPld{BiKGSxc3ZihLBl\XCnbnTlcpQhcW:maXTlJIVn\my3eNMg M1;odVI2OjZ|MkC3
L6 NIDxPYtHfW6ldHnvckBCe3OjeR?= MojCOFAhyrWP Mn7MNlQhcA>? NVqzO|RicW6qaXLpeJMhTE2KMT3pcoR2[2WmIFHreEBi[3SrdnH0bY9v M{W1clI2OjR5NUWw
MIN6  Mk\ESpVv[3Srb36gRZN{[Xl? MkPCNVAh|ryPwrC= MXKzJIg> NYe1T5BVcW6lcnXhd4V{KER|IH3SUmEh\XiycnXzd4lwdg>? NIDXPGgzPTJ2MUGyOC=>
ventricular cardiomyocytes  Mk\4SpVv[3Srb36gRZN{[Xl? NXLifmFkOC5yMT2xNEDPxE1? MlHSbY5kemWjc3XzJEBkSU2SIHHjZ5VufWyjdHnvci=> MXeyOVIxOzFzMx?=
ventricular cardiomyocytes  MoDGSpVv[3Srb36gRZN{[Xl? NVjWUnI4OC5yMT2xNEDPxE1? NHf6cYJmfm:tZYOgZY4hcW6xdILvdIlkKHKnc4DvcpNmKDF{MNMxNVUmKGGkb4\lJIJie2GuIIfpeIgh[W5iRVO1NOKhd2ZiMj6yJOK2VQ>? MUKyOVIxOzFzMx?=
BeWo  MVjGeY5kfGmxbjDBd5NigQ>? NIPsbFMzOCEEtV2= NFi0SYs1QCCq NUnqN5U3TE2VT9Mg MULpcoR2[2W|IHPlcIwh\nW|aX;u NFiyT2wzPTF6NES3Oy=>
THP-1  M2LRNWZ2dmO2aX;uJGF{e2G7 NEO2cHQyNzFyIN88US=> M4nLeVLDqGh? NWrDSnI1TE2VT9Mg MUHzeZBxemW|c3XzJG1EWC1zIIDyc4R2[3Srb39CpC=> NELTZYIzPTF3NEi4Ni=>
Huh-7 NH7LTndHfW6ldHnvckBCe3OjeR?= MnfTNE0zOCEQvF2= MX6yJIjDqA>? MWfy[ZN2dHS|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgbY5kemWjc3WgbY4h[y2PeXOg[ZhxemW|c3nvckBifCC2aHWgdJJwfGWrbjDhcoQhdVKQQTDs[ZZmdHN? MmfzNlUyODl6M{S=
C6 MXXGeY5kfGmxbjDBd5NigQ>? M4LY[lExKM7:TdMg NEnTV3QzOCCvaX6= MnPQbY5kemWjc3XzJINCVVBiYXPjeY12dGG2aX;u NIfzSlgzPTB4OUSxOy=>
SW480 M3SwTmZ2dmO2aX;uJGF{e2G7 MWW0NOKh|ryP M2jWOVQ5yqCq NHX3WYlFVVOR NHX4dFNi[3SrdnH0[ZMhWFB{QR?= NH7pb|kzPDl7N{S1NS=>
HT-29  NWq3N5dtTnWwY4Tpc44hSXO|YYm= NUTCeVJMPDEEoN88US=> MXS0POKhcA>? MkP5SG1UVw>? MmHZZYN1cX[jdHXzJHBROkF? NHvMdJUzPDl7N{S1NS=>
SW480 M13X[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\6eVQxyqEQvF2= M{XicVAuPzJiaB?= NGK0ZmpFVVOR MkSzbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> MkHrNlQ6QTd2NUG=
HT-29  NHLqbmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljGOFDDqM7:TR?= MUmwMVczKGh? NWn5V4hPTE2VTx?= MlLobY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> NIPQelUzPDl7N{S1NS=>
SW480 NEjxR5dHfW6ldHnvckBCe3OjeR?= MW[0NOKh|ryP M3HBS|ch\A>? NX:wc2NKTE2VTx?= NYfGRnZjemWmdXPld{Bkd2yxbn;zdIhmemViZn;ycYF1cW:wIHPhdIFjcWyrdIpCpC=> NGT5eYMzPDl7N{S1NS=>
HT-29  MVrGeY5kfGmxbjDBd5NigQ>? NFO0e3U1OMLizszN Mn;vO{Bl MlHXSG1UVw>? M4qyZ5Jm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= Mm\zNlQ6QTd2NUG=
SW480 NH\qd2VCeG:ydH;zbZMhSXO|YYm= MWS0NOKh|ryP M4[zRlQ5yqCq M17YfGROW09? M{G3Nolv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> MX2yOFk6PzR3MR?=
HT-29  M{DtXWFxd3C2b4Ppd{BCe3OjeR?= NEDWdms1OMLizszN NIT4[G41QMLiaB?= M4TEc2ROW09? MmO4bY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 NGPyWXMzPDl7N{S1NS=>
SW480 MkGwRZBweHSxc3nzJGF{e2G7 NVr3eXRvPDEEoN88US=> NFvPcFg1QMLiaB?= NFy0UoZFVVOR MX;pcoR2[2W|IHPoZY5o\XNiaX6geIhmKHCqb4PwbI9zgWyjdHnvckB{fGG2dYOgc4YhWFB{QTD0ZZJo\XS| NXXhSIJpOjR7OUe0OVE>
HT-29  NFf6eIJCeG:ydH;zbZMhSXO|YYm= M1TqeVQxyqEQvF2= NGn3NWM1QMLiaB?= M{H3[GROW09? MnnFbY5lfWOnczDjbIFv\2W|IHnuJJRp\SCyaH;zdIhwenmuYYTpc44he3SjdIXzJI9nKFCSMlGgeIFz\2W2cx?= M{LDPFI1QTl5NEWx

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
in solvent
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00864578 Withdrawn Primary Open Angle Glaucoma|Intraocular Pressure Sooft Italia April 2009 --
NCT00863811 Withdrawn Primary Open Angle Glaucoma|Intraocular Pressure Sooft Italia April 2009 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID