Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 M3LCd2Z2dmO2aX;uJGF{e2G7 MXmxNEDPxE1? NHfufmo3KGh? MV7pcoNz\WG|ZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJI93\XKneIDy[ZN{\WRiS1zIUFMh[XRiU{SzNy=> M1W3XlI3PDN3NEm4
Mo-DCs NFL0N45HfW6ldHnvckBCe3OjeR?= MnPhOVAh|ryP NUjFNnY1OjUkgJno MojMdJJwdW:2ZYOgTWwuOjNicILv[JVkfGmxbjDpckB1cGVic4Xw[ZJv[XSjboSgc4Yhgnmvb4PhckB{fGmvdXzheIVlKE2xLVTDd:Kh NYPPS|R6OjZ2MUK5OFg>
RBMECs  M1fEZ2Z2dmO2aX;uJGF{e2G7 M{PXRlXDqM7:TR?= NV63O3FyOcLiaB?= NYXi[oFv[myxY3vzJJRp\SCUYXOxJIlv[WO2aY\heIlwdiCrbnT1Z4VlKGK7IFXNRXAuUUl? NWfIVmhiOjZ|NUiwN|k>
INA-6 MnHLR4VtdCCYaXHibYxqfHliQYPzZZk> M3TMclAuOTByIN88US=> MUO3NwKBkWh? MWHpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= MVqyOlMxPjZ{NB?=
OPM-2 MWXD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlT4NE0yODBizszN Mme3O|LjiImq MoTabY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NILXVZMzPjNyNk[yOC=>
U266 NWf5S2xmS2WubDDWbYFjcWyrdImgRZN{[Xl? NH;KfoMxNTFyMDFOwG0> NIrwSoY4OuLCiXi= M4P5UIlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 M3X0e|I3OzB4NkK0
H929 MmLsR4VtdCCYaXHibYxqfHliQYPzZZk> MXGwMVExOCEQvF2= NFL6ZlM4OuLCiXi= M1zvSYlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 MUGyOlMxPjZ{NB?=
RPMI 8226 MkHZR4VtdCCYaXHibYxqfHliQYPzZZk> NFHTXoYxNTFyMDFOwG0> NVXVV4lYPzMkgJno NHjJT|NqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> MYSyOlMxPjZ{NB?=
MDCK  MmHpSpVv[3Srb36gRZN{[Xl? NIq3XmgyOCEEtV2= MormNlQhcA>? NYLaRpNkTE2VTx?= NEezNoF2eHKnZ4XsZZRmeyC2aHWg[ZhxemW|c3nvckBw\iCWR1[t{tIyKGGwZDDDWGdHyqB? NED4TWszPjJyMkO1Ni=>
MDCK  NU\H[44{TnWwY4Tpc44hSXO|YYm= NE[2NlQyOCEEtV2= MoXTNlQhcA>? MlPhSG1UVw>? MVvpcohq[mm2czD0bIUhcW6lcnXhd4VlKGW6cILld5Nqd25ib3[gSm4h[2G3c3XkJIJ6KFSJRj5OtlE> NYnLc4JxOjZ{MEKzOVI>
Spinal cords  NVXqZnZ3TnWwY4Tpc44hSXO|YYm= Mk\NNeKh|ryP NFfXflI{OCCvaX6= NWLNV3p7e3SrbYXsZZRmeyClQV3QJIxmfmWucx?= MW[yOlEzPjl{Nh?=
BeWo  NILEfVlHfW6ldHnvckBCe3OjeR?= NEKybWUzPeLCid88US=> NYPUTJhjOjRxNEivO|IhcA>? M{XGeoxm[WS|IITvJIFvKGmwY4LlZZNmKGmwIITo[UBmgHC{ZYPzbY9vKG:oIH;0bIVzKG[3c3nvckBu[XKtZYLz NFXne4kzPjB3M{W0PS=>
bovine oocytes Mof1SpVv[3Srb36gRZN{[Xl? NHnaV4gyODEEoN88US=> MVGxNuKhcA>? MlLsbY5pcWKrdIOgeIhmKGWoZnXjeEBw\iCQUGDBJIFv\C:xcjDOVHBEKHSxIIP0bY12dGG2ZTDy[ZN2dXC2aX;uJI9nKG2naX;zbZM> NX3nW292OjZyNUG2NVE>
Caco-2  MUnGeY5kfGmxbjDBd5NigQ>? M{nSWFAvOS9zL{GwJO69VQ>? M1TTbVIxyqCvaX6= NV7UUFh1cW6mdXPld{BiKGSxc3Wt[IVx\W6mZX70JIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgZ2FOWCCuZY\lcJM> NF;UTm4zPjB2OUGwNi=>
Caco-2  M{e3[GZ2dmO2aX;uJGF{e2G7 M3naflAvOS9zL{GwJO69VQ>? MWmyOEBp MkPmbY5kemWjc3XzJG1TWDJicILveIVqdiCuZY\lcC=> NYPN[JNXOjZyNEmxNFI>
AML-12  NYnjboozTnWwY4Tpc44hSXO|YYm= Moe3NlAh|ryP NV3weHJNOyCq NVn0S5JRfXC{ZXf1cIF1\XNidHjlJJBpd3OyaH;yfYxifGmxbjDs[ZZmdHNiYYSgWIhzNTRzMTDhcoQhW2W{LUS5Ny=> NF6x[|QzPjB2OEm4OS=>
AML-12  MW\GeY5kfGmxbjDBd5NigQ>? MlHSNlAh|ryP NVHTSlNZOS16IHi= NWLqd4pYcW6lcnXhd4V{KGeudXPvd4UheHKxZIXjeIlwdg>? NWKwbXZKOjZyNEi5PFU>
AML-12  NV3QemlPTnWwY4Tpc44hSXO|YYm= MW[yNEDPxE1? Ml7GN{Bp MXX1dE1z\We3bHH0[ZPDqFCpY{HhMOKhWGWyY3usJIFv\MLiR{\wZ:KhdVKQQTDs[ZZmdHN? NHfFbYwzPjB2OEm4OS=>
AML-12  M3TZbGZ2dmO2aX;uJGF{e2G7 MUGyNEDPxE1? MX2zJIg> NIHKToFqdmS3Y3XzJJRp\SCmZYDoc5NxcG:{eXzheIlwdiCxZjDDVnREOsLi NVvId25SOjZyNEi5PFU>
RBMECs NHnXUllHfW6ldHnvckBCe3OjeR?= NUjvSVZ7PcLizszN NFjnU3cyKGh? M2TTOIlvcGmkaYTzJGVOSVBvSVmtbY5lfWOnZDDpcoFkfGm4YYTpc44hd2ZiUnHwNeKh NHzMbnkzPjB2NE[2Ny=>
EndoC-βH1 MYLGeY5kfGmxbjDBd5NigQ>? NHvp[ng2yqEQvF2= M3\wV|EhcA>? MmTIdI91\W62aXH0[ZMh\2y3Y3;z[U1qdmS3Y3XkJIlve3WuaX6gd4VkemW2aX;uJIlvKHSqZTDwdoV{\W6lZTDv[kBodHWlb4Pl NVr1[Y06OjZyMki1OlI>
EndoC-βH1 M2XoXGZ2dmO2aX;uJGF{e2G7 NGrG[nY2yqEQvF2= NXqxOZlQOSCq MoDYcIVi\HNidH:gZUB{fHKxbnegZ2FOWCCrbnPy[YF{\Q>? NEDuXGIzPjB{OEW2Ni=>
SH-SY5Y NFvzWpdHfW6ldHnvckBCe3OjeR?= NUXPR|Y1OzBizszN NHjqN40{OCCvaX6= NFzKR4pFVVOR NIS4RZR{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUh[WO2aY\heIlwdiCxZjDQT2E> MVGyOlAzPTF|Nx?=
PC-3 MX3GeY5kfGmxbjDBd5NigQ>? NWHKNW94PDBiwsXN MnnmNkBp M2H1OGROW09? MmHvcIVi\HNidH:gVHAzSSCjY4TpeoF1cW:w NWr6eFJ6OjZyMkO4N|Y>
PC-3 NVXSVWwzS2WubDDWbYFjcWyrdImgRZN{[Xl? M1zoZ|QxKML3TR?= MnPUNlQwPDhxN{KgbC=> M{jFV2ROW09? NXTYOYl7\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJRqdWViZHXw[Y5l\W62bIm= NFzyV2szPjB{M{izOi=>
SCG NV3rclVXTnWwY4Tpc44hSXO|YYm= MmPMNlAh|ryPwrC= NFXSOnJFVVOR NYLMUmNZemW4ZYLzbYJtgSC|dYDwdoV{e2W|IFnLWkB4cXSqIHGgTWM2OCCxZjCyOE41KM7:TR?= Mke3NlU6PjJzM{K=
HEK-293 NEPaPIhHfW6ldHnvckBCe3OjeR?= NH;Eco0{PSEQvF5CpC=> NFnhW4JFVVOR M1vVNIlv\HWlZYOgZUBkd26|cHnjeY92eyEkgKzpcoFkfGm4YYTpc47jiJ1ib3[geIhmKEu4Mj6xJIN2enKnboS= MoKyNlU6PjJzM{K=
SCG NUP3codlTnWwY4Tpc44hSXO|YYm= MY[xNFAh|ryPwrC= MkLISG1UVw>? MVXy[YR2[2W|IITo[UBmgGOrdHHibYxqfHlib3[gV2NIKG6ndYLvcpM> NXTveldsOjV7NkKxN|I>
PCCL3 M3XPNWZ2dmO2aX;uJGF{e2G7 NV7sWZB2OTBiwsXN M{S1VVI1KGh? MVnlcohidmOnczDEeW95OiCycn;tc5RmeiC2cnHud4NzcXC2aX;uJIFkfGm4aYT5xsDjiIt? MYWyOVk3ODl3Nh?=
3T3-L1 preadipocytes NYHJXFRJTnWwY4Tpc44hSXO|YYm= NYXMRllWOTBizszNxsA> NFjlWVEyOiCq NEeyWZNqdmS3Y3XzJGNTTUJicHjvd5Bpd3K7bHH0bY9vKGGwZDDDM2VDWM7{IHX4dJJme3Orb36= MWSyOVkzQDB3OB?=
H295R  MXvGeY5kfGmxbjDBd5NigQ>? MV2xNOKh|ryP MVK0POKhcA>? NI\EUmhqdmO{ZXHz[ZMhe3Sncn;p[EBu\XSjYn;sbZRmeyCrbjD0bIUh[W6mcn;n[Y4tKG2rbnXyZYxwNSCjbnSg[4x2[2:lb4L0bYNwcWRicHH0bJdigXN? MYmyOVg3QTV3Nh?=
PBMC Ml7jSpVv[3Srb36gRZN{[Xl? M{O2b|UxyqEQvF2= MmfTNlTDqGkEoB?= NHH1dWFqdmirYnn0d{B1cGViaX7jdoVie2WmIIPlZ5JmfGmxbjDv[kBVVkZiaX7keYNm\CCkeTD0bIUhTFCH NXrGZpdoOjV6Nk[wO|k>
GLUTag  NUPCbJYxTnWwY4Tpc44hSXO|YYm= NEexeVcyOOLCidM1US=> M3TDd|AwOi92IHi= NIK3c|J{fGmvdXzheIV{KEeOUD2xJJNm[3KndHnvckBkd3S{ZXH0[YQhf2m2aDDJRm1Z MYCyOVg{OjZ|MR?=
GLUTag  M4H6e2Z2dmO2aX;uJGF{e2G7 M1rDbVEx6oDLwsXN NVr3cm5VPCCq NV3iRXRncW6lcnXhd4V{KHSqZTDwR3JGSiCuZY\lcJMhf2m2aDD0bIUhUUKPWB?= NETt[mczPTh|Mk[zNS=>
BAECs MV\GeY5kfGmxbjDBd5NigQ>? NFS5[FIzPSEQvF2= NVHBZldPOjRiaB?= NWfmd3Rz\W6qYX7j[ZMhfGinIHHjeIl3[XSrb36gc4YhWFCDUt8xJIJ6KDVizszNJJJme3[ncnH0do9tNCCWNFjTMEBweiB2LWDBVC=> NH31VY8zPTd7OEiyOi=>
PC12 MmCwSpVv[3Srb36gRZN{[Xl? NFfFO3EzPcLizszN M{HrVFQ5KGh? M3H4e4FkfGm4YYTld{BkSU2S MUKyOVc3QTNyNR?=
GH3 M1XtdmZ2dmO2aX;uJGF{e2G7 NHXoZWYyyqEQvF2= MYK2MYg> NEDsc2ZifHSnboXheIV{KHSqZTDjc5Jz\WyjdHnvckBj\XS5ZXXuJHBTVCCjbnSgRo1idDFiZYjwdoV{e2mxbh?= M1rGbFI2PzJ5MEG4
GH3 NYCxPHhPTnWwY4Tpc44hSXO|YYm= NIO0cZkyyqEQvF2= MXS2MYg> MWjpcoR2[2W|IGDSUEBidmRiQn3hcFEtKGK3dDDuc5QhS2yxY3usJI1TVkFiZYjwdoV{e2mxbh?= M2PORlI2PzJ5MEG4
BeWo MlqySpVv[3Srb36gRZN{[Xl? NEX5RlkyOOLCit88UeKh NHXHNoM4OiCq M4jNNWROW09? NHzXcIdu\WSrYYTld{BD\VexIHPlcIwh\GmoZnXy[Y51cWG2aX;u M2npS|I2PzF|NEK1
oocytes MXHGeY5kfGmxbjDBd5NigQ>? NX7EPJRRPSEQvF2= MkDmNlQhcA>? MULheJRmdnWjdHXzJJJpNWmwc4XsbY4h[WO2aX;uJI9vKG:xY4n0[UBIXkKGIIPp[45q\mmlYX70cJnDqA>? NVPUVpZ6OjV5MEe4OVQ>
SC M1H0[GZ2dmO2aX;uJGF{e2G7 NUKzOY9UOC53IN88US=> MUOyOEBp MYntbY1q[2u|IITo[UBm\m[nY4Sgc4Yh[0GPUDDhcoFtd2e|IH;uJG8yKGGwZDDNRnAh\XiycnXzd4lwdg>? MojuNlU4ODV6N{S=
SC NXHCdldGTnWwY4Tpc44hSXO|YYm= M1XHT|AvPSEQvF2= NILJNFc4OiCq NXLmclJWcW6lcnXhd4V{KGKxdHigT5JwgC1{MDDhcoQhVzFiZYjwdoV{e2mxbjDpckBigG:wLYLlcIF1\WRiU1PzJIJ2fCCxbnz5JGtzd3hvMkFCpC=> M4XRe|I2PzB3OEe0
UACC-647  NVzhdo1ZTnWwY4Tpc44hSXO|YYm= MlvvSG1UVw>? NWnSe2tkdGWjZIOgeI8h[SC{aYPlJIlvKGODTWCgcIV3\Wy|IDjFR|UxyqB;wrCyNE4{QcLizszNLS=> NHnVUHczPTdyM{CyOS=>
UACC-647  MYDGeY5kfGmxbjDBd5NigQ>? MoXjNVDDqM7:TR?= NY\DOVVPOTVibXnu NWDxN|FPTE2VTx?= MVzpcohq[mm2czDFVmsheGixc4Doc5J6dGG2aX;u MV[yOVcxOzB{NR?=
UACC-647  MYLGeY5kfGmxbjDBd5NigQ>? NHThWoIyOMLizszN MVexOUBucW5? Mn[zSG1UVw>? NHzEV5FqdmO{ZXHz[ZMh\UWIMjDwbI9{eGixconsZZRqd25ibHX2[Yx{yqB? Mn;qNlU4ODNyMkW=
SH-SY5Y  M2HGUWZ2dmO2aX;uJGF{e2G7 MmixNVDDqM7:TR?= MnjONeKhcMLi MorCbY5kemWjc3XzJGxWSyCjY4Tpeol1gQ>? MXyyOVU6PzR|Mx?=
SH-SY5Y  NUjac3FUTnWwY4Tpc44hSXO|YYm= NGXseHAyOMLizszN MV:xxsBpyqB? MXPpcoNz\WG|ZYOgRWdEOSCvUl7BJIxmfmWu NHHwU44zPTV7N{SzNy=>
hADSCs M3exZmZ2dmO2aX;uJGF{e2G7 NGGwWGw26oDLwsXN MkfCN|AhdWmw NX\RSJE6cW6lcnXhd4V{KGODTWCgcIV3\Wy| MWOyOVU6OTlyOB?=
HEK293  M1P0WWZ2dmO2aX;uJGF{e2G7 MWq15qCKyrWP MWCzNEBucW5? NEHmcG1qdmO{ZXHz[ZMh[0GPUDDs[ZZmdHN? NHrjPYYzPTV7MUmwPC=>
3T3-L1 MlPYSpVv[3Srb36gRZN{[Xl? M3;kOFIvPS93IN88US=> M1nGRlI1KGkEoB?= MYjzbYdvcW[rY3HueIx6KGSnY4LlZZNmeyCDVFfMJJBzd3SnaX6g[ZhxemW|c3nvckBifCCjbHyg[I9{\XNidHXzeIVl MWSyOVU6ODV7Nx?=
OCI-Ly1  MWnGeY5kfGmxbjDBd5NigQ>? MX20NOKh|ryP Mlq2NeKhcMLi NH:5bJRFVVOR MUDpcoR2[2W|IITo[UBqdmO{ZX3lcpQhd2ZiY1HNVEBkd26lZX70doF1cW:wcx?= MXuyOVU4PjJ{MB?=
OCI-Ly18  MYXGeY5kfGmxbjDBd5NigQ>? NV7yfWhoPDEEoN88US=> NIntW3MyyqCqwrC= NEX0WHJFVVOR Mm\wbY5lfWOnczD0bIUhcW6lcnXt[Y51KG:oIHPBUXAh[2:wY3XueJJifGmxboO= MYGyOVU4PjJ{MB?=
BeWo NUf1W4F6TnWwY4Tpc44hSXO|YYm= MU[yNOKhyrWP NH7UWJY1QMLiaB?= M3j3emROW09? M2LOe4lv[3KnYYPld{B1cGViZHnm[oVz\W62aXH0bY9vKG:oIFLlW48h[2WubIO= NIjYUI8zPTV4Nke0NC=>
BeWo Mn25SpVv[3Srb36gRZN{[Xl? NWLVTlZmOjEEoNM1US=> MUC0POKhcA>? NV3se5lvTE2VTx?= MUHpcoNz\WG|ZYOgeIhmKGGmaHXzbY9vKG:oIGTIVE0yKG2xbn;jfZRmew>? NXq5cG81OjV3Nk[3OFA>
LNCaP  MnHFSpVv[3Srb36gRZN{[Xl? NEHhcpIyOMLizszN MlvJNVIhcMLi NYLSbZRxTE2VTx?= M1fl[4lv\HWlZYOgZUBlemGvYYTpZ{BqdmO{ZXHz[UBw\iCFUlXCNUBi[3Srdnn0fS=> MnfhNlU2PDhyOUm=
ThGCs  MoPmSpVv[3Srb36gRZN{[Xl? M1HMd|Ex6oDMzszN NFfabmY16oDMaB?= M1LNWIF2\22nboTzJGhKTjGDIHzleoVteyC2aHH0JJdmemVic4TpcZVt[XSnZDDifUBEd0OuMh?= Mn7kNlU1OzNyMke=
ThGCs  NIjtcGNHfW6ldHnvckBCe3OjeR?= Mn;oNVDjiIsQvF2= Mn[xOQKBkmh? NEjkOo1qdmO{ZXHz[ZMhS2:FbEKtbY5lfWOnZDDFSG4zyqCpZX7lJIV5eHKnc4Ppc44> NYH6eGFGOjV2M{OwNlc>
ThGCs  NHvlTlFHfW6ldHnvckBCe3OjeR?= NXXBSoE{OTEkgJtOwG0> NUHVPFFHOyCq NYfVbot5cW6qaXLpeJMhfGinIHXm[oVkfCCxZjDINm8zKG:wIFXEUlIhdVKQQR?= M3\udVI2PDN|MEK3
RBMECs NFTQcolHfW6ldHnvckBCe3OjeR?= MlrQNE4xPS9yLkWvOUDPxE1? NX\WbYtTOC5{NTDo MWrpcoNz\WG|ZYOgZ2FOWCClb37j[Y51emG2aX;u M4\5cFI2PDF4NkWx
RBMECs M2X1NGZ2dmO2aX;uJGF{e2G7 NELGfVI2yqEQvF2= NF;UXoIyKGh? M1fFdYJtd2OtczD0bIUh[WO2aY\heIlwdiCxZjDSbI9CN1KRQ1ugbY5lfWOnZDDifUBGVUGSLVnJ M3v0UVI2PDF4NkWx
RBMECs MWrGeY5kfGmxbjDBd5NigQ>? MoPBOeKh|ryP NGHCT|gyKGh? NWTvS3IzeHKndnXueJMhfGinIFXNRXAuUUlvaX7keYNm\CCWRVXSJJZidHWnIHTlZ5Jm[XOn NYTNTZpQOjV2MU[2OVE>
RBMECs M17NcWZ2dmO2aX;uJGF{e2G7 NYH5NlBEPcLizszN MWSxJIg> NGPkemFxemW4ZX70d{B1cGViaX7jdoVie2ViaX6gTHJRKG[udYigZYNzd3O|IITo[UBDXEJiaX7keYNm\CCkeTCgSW1CWC2LSR?= MX6yOVQyPjZ3MR?=
RBMECs NEnFfHZHfW6ldHnvckBCe3OjeR?= NHKzZmo2yqEQvF2= NX3jbotGOSCq MUTpcohq[mm2czD0bIUh\GWlcnXhd4VlKG:oIHHtc5VvfCCxZjDaU{0yKGmwIF3Gd{BqdmS3Y3XkJIJ6KEWPQWCtTWk> M1HYblI2PDF4NkWx
RBMECs MUXGeY5kfGmxbjDBd5NigQ>? MnzhOeKh|ryP M2fkWlEhcA>? MV\y[ZZmenOnczD0bIUh[2ijbnfld{BqdiCcTz2xJIRqe3S{aXL1eIlwdiC|ZXXuJJdqfGhiRV3BVE1KUSC2cnXheI1mdnR? MYWyOVQyPjZ3MR?=
RBMECs M3nKd2Z2dmO2aX;uJGF{e2G7 NF\WRYs2yqEQvF2= MUOxJIg> Ml7HZoxw[2u|IITo[UBGVUGSLVnJMYlv\HWlZXSgZ4hidmenIHnuJG1NSyCyaH;zdIhwenmuYYTpc44> MWmyOVQyPjZ3MR?=
RBMECs MnzQSpVv[3Srb36gRZN{[Xl? M3\Zc|XDqM7:TR?= MYKxJIg> NWDQd|Y4[myxY3vzJJRp\SCjY4TpckBkgXSxc3vlcIV1d25icnXhdpJidmenbXXueEB{\WWwIIfpeIghTU2DUD3JTUB1emWjdH3lcpTDqA>? M{jvZVI2PDF4NkWx
Primary bovine chondrocytes MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;Sb|XPxE1? M1vkVVQ5KGh? M2S4UZJmfmW{c3XzJJRp\SCrbnjpZol1d3K7IHXm[oVkfCCxZjDj[Yxm[2:6aXKgc44heHKxbHnm[ZJifGmxbjDpckBoem:5dHigdIxifGViY3jvcoRzd2O7dHXz MnOyNlU1ODZyMU[=
EM1  NFmz[mpHfW6ldHnvckBCe3OjeR?= NFTxS4gyPeLCit88US=> M3rVfVQ5KGh? M3K3c5Jm\HWlZYOgeIhmKGW6cILld5Nqd25ib3dCpGxKTsLib4NCpHBVT1N{wrDpcuKhS0GOUj2gc5LDqEWSQVOyMZNqdGWwY3XkJGVOOSClZXzsd:Kh M3y5[VI2Ozd6Nk[x
BeWo  NVK2dIF2TnWwY4Tpc44hSXO|YYm= NXPnVVliOjEEoNM1US=> MlLLOFjDqGkEoB?= NWS4eZdqTE2VT9Mg MXTpcoNz\WG|ZYOgeIhmKGKndHGtbGNIKHKnbHXhd4U> NHfaPHkzPTN4MkK2NC=>
BeWo  MmThSpVv[3Srb36gRZN{[Xl? M1viZlIxyqEEtV2= NEn4dFM1QMLiaNMg NUDxRnpbTE2VT9Mg NHTGTIFld3ewcnXneYxifGW|IITo[UBt\X[nbDDv[kBVVUWPRkG2 MU[yOVM3OjJ4MB?=
BeWo  MorSSpVv[3Srb36gRZN{[Xl? M1jZOlIxyqEEtV2= NX;ySHRPPDkEoHlCpC=> NVHXRldITE2VT9Mg NETxSGZld3ewcnXneYxifGW|IITo[UBt\X[nbDDv[kBIS01vMR?= NVPYZXp[OjV|NkKyOlA>
granulosa cells MYrGeY5kfGmxbjDBd5NigQ>? NFTwSW4yOCEQvF2= NXq4XIZ6OTJxMkSgbC=> NGqzSXZqdmO{ZXHz[ZMhfGinIHzleoVteyCxZtMgVmdUOsLibWLORS=> M1[y[FI2OzN7MUC1
granulosa cells MkPzSpVv[3Srb36gRZN{[Xl? M13qW|ExKM7:TR?= M1SxSFEzNzJ2IHi= NUjwT|NWcW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gdoVxd3K2ZYKgZYN1cX[rdImg[o9zKHSqZTDsc45o\XO2IH\yZYdu\W62IDlijLI5PTRxK{G4VmdUOi6OVVOp MoXCNlU{OzlzMEW=
granulosa cells NHrhcVBHfW6ldHnvckBCe3OjeR?= MXWxNEDPxE1? MVeyOEBp M4jafolv[3KnYYPld{B1cGViaX70[Y5{cXS7IH;mJGRPSS:ycn;0[YlvKGOxbYDs[Zg> NGHkRlgzPTN|OUGwOS=>
granulosa cells MnW5SpVv[3Srb36gRZN{[Xl? MUmxNEDPxE1? MnfjNlQhcA>? NYPye3lycW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gVmdUOiCycn;tc5RmeiCjY4Tpeol1gQ>? MVqyOVM{QTFyNR?=
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SK-N-AS  MmjmSpVv[3Srb36gRZN{[Xl? NHnnSIQyOCEQvF5CpC=> MlPxNlQhcA>? NH7sPYVqdmO{ZXHz[ZMhfGinIHPBUXAhdGW4ZXzzxsA> MojJNlUzPjZyNkO=
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SK-N-AS  NUe3ZW8xTnWwY4Tpc44hSXO|YYm= NELWbo4yOCEQvF5CpC=> NHPrPXoyOC9|MD:2NEBucW5? NFHVdnFqdmO{ZXHz[ZMhdGW4ZXzzJI9nKHBvzsKtZ4F1\W6rbjCod4VzPjd3KTDhcoQhcW6mdXPld{Bi[2O3bYXsZZRqd25ib3[gdE3Pui2lYYTlcolvKCi|ZYK2O|UqKGmwIDjw[ZJqMW63Y3zlZZIhemWpaX;udy=> MUSyOVI3PjB4Mx?=
SK-N-SH NVLmbo9kS2WubDDWbYFjcWyrdImgRZN{[Xl? Mn[yNVAh|ryPwrC= MWS0PEBp NXnxOnB1\W6qYX7j[ZMhW0tvTj3TTEBv\XW{b3LsZZN1d22jIHPlcIwhfmmjYnnsbZR6 NXXqR5NoOjV{Nk[wOlM>
HEK‐CFTR M1jIPWZ2dmO2aX;uJGF{e2G7 M{W2VVLjiJN3MNMg{txO MojONE0yOiCvaX6= MV3EUXNQyqB? MWrpcoR2[2W|IHGg[I9{\eLCkHTldIVv\GWwdDDpc4Rq\GViZX\mcJV5yqB? NETUXlczPTJ4M{KwOy=>
L6 MWXGeY5kfGmxbjDBd5NigQ>? NUTyV2s5PDBiwsXN MY[yOEBp MXnpcohq[mm2czDEUWgyNWmwZIXj[YQhSWu2IHHjeIl3[XSrb36= NVnEXHc3OjV{NEe1OVA>
MIN6  M3LmfGZ2dmO2aX;uJGF{e2G7 MYSxNEDPxE4EoB?= M2qwfFMhcA>? NXHueI1GcW6lcnXhd4V{KER|IH3SUmEh\XiycnXzd4lwdg>? M1vaZ|I2OjRzMUK0
ventricular cardiomyocytes  M2DoeWZ2dmO2aX;uJGF{e2G7 M3jUS|AvODFvMUCg{txO MlnNbY5kemWjc3XzJEBkSU2SIHHjZ5VufWyjdHnvci=> NGnRclQzPTJyM{GxNy=>
ventricular cardiomyocytes  NUO4V5psTnWwY4Tpc44hSXO|YYm= MVWwMlAyNTFyIN88US=> MVfleo9s\XNiYX6gbY5wfHKxcHnjJJJme3CxboPlJFEzOMLzMUWlJIFjd3[nIHLhd4FtKHerdHigZY4hTUN3MNMgc4YhOi5{INM1US=> NWnmVmNxOjV{MEOxNVM>
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THP-1  MUHGeY5kfGmxbjDBd5NigQ>? MWSxM|ExKM7:TR?= NHvRfWIzyqCq MnLpSG1UV8Li M1v3dZN2eHC{ZYPz[ZMhVUOSLUGgdJJw\HWldHnvcuKh M2n3ZlI2OTV2OEiy
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SW480 MoPOSpVv[3Srb36gRZN{[Xl? MkPDOFDDqM7:TR?= M3P6SVQ5yqCq NG\QeWJFVVOR NHfwb2li[3SrdnH0[ZMhWFB{QR?= NE[zPZAzPDl7N{S1NS=>
HT-29  NYrZZpJITnWwY4Tpc44hSXO|YYm= NWTOdZVCPDEEoN88US=> M{XXOFQ5yqCq NYjlRZVsTE2VTx?= MnTmZYN1cX[jdHXzJHBROkF? MoGzNlQ6QTd2NUG=
SW480 M2jkbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnibZY1OMLizszN NYr1eoZTOC15MjDo NImy[ZdFVVOR MVHpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nIHTldIVv\GWwdHz5 NHPI[o0zPDl7N{S1NS=>
HT-29  M3ixVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\qfWdqPDEEoN88US=> MmHvNE04OiCq MnW4SG1UVw>? Mn7lbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> NWjZbVJXOjR7OUe0OVE>
SW480 MULGeY5kfGmxbjDBd5NigQ>? MnjDOFDDqM7:TR?= MonkO{Bl M{\2S2ROW09? NITDVZBz\WS3Y3XzJINwdG:wb4PwbIVz\SCob4LtZZRqd25iY3HwZYJqdGm2edMg MYKyOFk6PzR3MR?=
HT-29  M3nlV2Z2dmO2aX;uJGF{e2G7 MXm0NOKh|ryP MV63JIQ> MlvaSG1UVw>? M4rSWpJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= NGfWTnEzPDl7N{S1NS=>
SW480 MXXBdI9xfG:|aYOgRZN{[Xl? MUK0NOKh|ryP M321cVQ5yqCq NXLZbYlWTE2VTx?= M1jaSolv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> M2n6fVI1QTl5NEWx
HT-29  NXLqcGhFSXCxcITvd4l{KEG|c3H5 M2jiPFQxyqEQvF2= NUPFWpRoPDkEoHi= NF64UoZFVVOR MWDpcoR2[2W|IHHuJIFkfGm4YYTpc44hd2ZiY3HzdIF{\SB|L{e= M37vV|I1QTl5NEWx
SW480 MmruRZBweHSxc3nzJGF{e2G7 Mk\5OFDDqM7:TR?= MmDwOFjDqGh? MnrrSG1UVw>? MmLRbY5lfWOnczDjbIFv\2W|IHnuJJRp\SCyaH;zdIhwenmuYYTpc44he3SjdIXzJI9nKFCSMlGgeIFz\2W2cx?= M4rZdVI1QTl5NEWx
HT-29  NYnKdXpvSXCxcITvd4l{KEG|c3H5 NIHqTXk1OMLizszN MYO0POKhcA>? MXjEUXNQ MXPpcoR2[2W|IHPoZY5o\XNiaX6geIhmKHCqb4PwbI9zgWyjdHnvckB{fGG2dYOgc4YhWFB{QTD0ZZJo\XS| NWnpc45IOjR7OUe0OVE>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
in solvent
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00864578 Withdrawn Primary Open Angle Glaucoma|Intraocular Pressure Sooft Italia April 2009 --
NCT00863811 Withdrawn Primary Open Angle Glaucoma|Intraocular Pressure Sooft Italia April 2009 --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID