Lapatinib (GW-572016)

For research use only.

Catalog No.S2111 Synonyms: GSK572016, GW2016

397 publications

Lapatinib (GW-572016) Chemical Structure

CAS No. 231277-92-2

Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.

Selleck's Lapatinib (GW-572016) has been cited by 397 publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Lapatinib (GW-572016, GSK572016, GW2016), used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. Lapatinib induces ferroptosis and autophagic cell death.
Targets
ErbB2 [1]
(Cell-free assay)
EGFR [1]
(Cell-free assay)
ErbB4 [1]
(Cell-free assay)
9.2 nM 10.8 nM 367 nM
In vitro

Lapatinib weakly inhibits the activity of ErbB4 with IC50 of 367 nM, and displays >300-fold selectivity for EGFR and ErbB2 over other kinases such as c-Src, c-Raf, MEK, ERK, c-Fms, CDK1, CDK2, p38, Tie-2, and VEGFR2. Lapatinib significantly inhibits receptor autophosphorylation of EGFR and ErbB2 in a dose-dependent manner with IC50 of 170 nM and 80 nM, respectively in HN5 cells; as well as 210 nM and 60 nM, respectively in BT474 cells. Unlike OSI-774 and Iressa (ZD1839) which preferentially inhibit the growth of the EGFR-overexpressing cells, Lapatinib inhibits the growth of both EGFR- and ErbB2-overexpressing cells. Lapatinib displays higher inhibitory activity against EGFR- or ErbB2-overexpressing cells with IC50 of 0.09-0.21 μM, compared with cells expressing low levels of EGFR or ErbB2 with IC50 of 3-12 μM, and exhibits ~100-fold selectivity over the normal fibroblast cells. Lapatinib potently inhibits the outgrowth of EGFR-overexpressing HN5 and A-431 cells, as well as ErbB2-overexpressing BT474 and N87 cells, and significantly induces G1 arrest of HN5 cells and apoptosis of BT474 cells, which are associated with inhibition of AKT phosphorylation. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LB2241-RCC MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnGTWM2OD1zLkG1OFA{KM7:TR?= M3i1WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
TE-9 M2jjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwN{S0OVMh|ryP NUW3fYdpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
A388 NEH6SWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z4OmlEPTB;MD63NlI2QCEQvF2= NWn5NGpVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
TE-12 NYLjVWxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwNEmwOVch|ryP MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
EKVX M3TIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\wVpVKSzVyPUCuOFQ5PzRizszN NVzh[4xCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
BB30-HNC NYPzOpFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fyV2lEPTB;MD6yOFY2PCEQvF2= NUXCeWJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
BT-474 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMkGzNVUh|ryP M2nlTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
DSH1 NFn0[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX6WZNKSzVyPUCuNFk{QTZizszN M{LSW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
ECC12 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\rdXdKSzVyPUCuNFkzOzFizszN MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
OCUB-M NYPOcFV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[xd|M2UUN3ME2wMlA2PzRizszN NYfKVmtTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
HCC2218 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDIOWJXUUN3ME2wMlA2OzJ4IN88US=> MmXWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
NCI-H1648 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEK1OFQh|ryP NWTPVFltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
LB996-RCC NUjXcmNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwM{[yNlgh|ryP MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LC-1F MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3hTVNKSzVyPUGuN|gzPDRizszN MnS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TE-6 M3nxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jFRWlEPTB;MT61OVIxOSEQvF2= M{jiT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A253 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPKUFdKSzVyPUGuPVc{OzVizszN MkTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
OS-RC-2 NUD3eld3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rvTWlEPTB;MT65PVE6QSEQvF2= NF3jbmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-1 NFK0RXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\rTWM2OD1{LkC0PFMh|ryP MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
RL95-2 MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzkTWM2OD1|LkG1Olch|ryP MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LS-513 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTNwNECwOFEh|ryP M2\BcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
DJM-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2q2NGlEPTB;Mz60Olk4PSEQvF2= M2\VXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NMC-G1 Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHUblZKSzVyPUOuOVQ2ODFizszN MlrRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TE-10 NUX2OGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTNwNUWzOVYh|ryP MmXCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
TE-5 NWq5eo96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTRwMEO3N{DPxE1? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
TK10 M2PVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTRwMU[1NlIh|ryP NWnWV3FPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
UACC-812 M3vCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vO[WlEPTB;ND61OlE2OyEQvF2= NWe4[3NpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
SW962 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:wWWlEPTB;NT6wNlE2QSEQvF2= NHe4T|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SW954 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\zZoZ6UUN3ME21MlM6OjR3IN88US=> M{G1T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
COLO-668 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX72ZYpKUUN3ME21MlczPjZ5IN88US=> MmXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LB1047-RCC MmTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTVwOECwOFYh|ryP NIrmRo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
NB5 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXtd2dKSzVyPU[uNlExODFizszN NIP6VZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
NTERA-S-cl-D1 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTZwMk[1OlEh|ryP M13hPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
IST-MEL1 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP2OnRnUUN3ME22MlQ{Pjl2IN88US=> MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
GI-1 M2nlRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIm4NnFKSzVyPU[uOVE3QDJizszN NF;xblc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TGBC1TKB MkKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XsfWlEPTB;Nz6wO|E5OyEQvF2= M{LQ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
GT3TKB M13JXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\5R2lEPTB;Nz6yNlc1PCEQvF2= MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
EVSA-T NUG0WJNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13H[2lEPTB;Nz60NlgyOSEQvF2= M{jVd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
D-502MG MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTdwNEi4PVQh|ryP NXLQVGRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
TE-8 M4i1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTdwN{[xOVkh|ryP M{OzPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
OVCAR-4 NXP1UGVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vJXWlEPTB;OT6xNVY4PSEQvF2= NH7YdJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
D-336MG NYHIOGxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7PO25KSzVyPUmuOFc{QTVizszN NVrtO3p{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
GCIY M4[zPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPNRXlKSzVyPUmuOVc1OiEQvF2= NVztO454RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
KS-1 NYLGZZV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEKxRpRKSzVyPUmuOlYzQDdizszN MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
HCC2998 M4rn[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHoTWM2OD17Lkm2N|A4KM7:TR?= NEO0fpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
D-247MG NH[yOFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXITI5KSzVyPUmuPVgzQTFizszN NWfvc2pRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
TE-15 NYjJN4NET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTFyLkK0OUDPxE1? MlLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
IST-MES1 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TxcGlEPTB;MUCuNlU3PSEQvF2= NV3vSXJzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
ETK-1 MmKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zVc2lEPTB;MUCuOlI{KM7:TR?= NU\2dGllRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
RCC10RGB MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;TOnBKSzVyPUGwMlk3OSEQvF2= NEewVJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
KNS-42 MkjrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTFzLkeyOVUh|ryP MmPYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LB771-HNC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj4TWM2OD1zMj6xO|EzKM7:TR?= M2nObVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
SR MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P2eGlEPTB;MUKuNlA3PCEQvF2= M2fu[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NCI-H1355 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjNbnhKSzVyPUGyMlg6QDVizszN MnzwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
ES6 NWXDVY9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TwXmlEPTB;MUOuNFc5KM7:TR?= NWLTRnNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
SK-NEP-1 NIPQRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF|LkK1O|ch|ryP NWfORlBZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
D-392MG M4HDS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfoe2cyUUN3ME2xN{43PDJ6IN88US=> MkDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
NB7 NG\VUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;IdWlEPTB;MUSuNlM4PCEQvF2= NIiyTXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SK-LMS-1 Mo\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF2LkWxOFUh|ryP MmXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
SK-UT-1 NFTpZYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfQTWM2OD1zND63PFg6KM7:TR?= M1\B[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
CA46 NXOxZmJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fLXmlEPTB;MUWuNFU5PiEQvF2= NGjVTFg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
IST-SL2 NHrNTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\hTWM2OD1zNT6xPVAyKM7:TR?= MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
BC-1 M3XtS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF3LkOzNVQh|ryP Mk\KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LS-123 M1[4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFX1fphKSzVyPUG1MlgyPzNizszN NH;GNlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
Ramos-2G6-4C10 NHPP[3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHETWM2OD1zNj6wPVI1KM7:TR?= MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
MZ1-PC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF4LkezNVMh|ryP Ml3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
LB647-SCLC M3z6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\ScmlEPTB;MU[uPVM4OiEQvF2= M{\aWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NCI-H1694 MkXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF5LkG1Nlkh|ryP M3fj[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NCI-H322M NWnK[oZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTF5LkSzOlYh|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
ES7 NU\KVXlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELVNJNKSzVyPUG4MlM6OTRizszN NGjENZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LC-2-ad NEnvW2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoCwTWM2OD1zOD60N|g3KM7:TR?= NHq4dWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SF268 M1THe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD1bVdUUUN3ME2xPE44PDB7IN88US=> NH\Kb|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
RPMI-8402 NVrrfHVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTF7LkC3OFIh|ryP NGmxTWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
HCE-T M{DpRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX4XpExUUN3ME2yNE4zOzR2IN88US=> M16yWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A101D NFHV[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjyPIJVUUN3ME2yNE45PTh5IN88US=> NVrGWFBjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
MRK-nu-1 NWr0dotFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXTXmpbUUN3ME2yNE46OTNizszN NFzYTFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LXF-289 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLTXVh6UUN3ME2yNU4xOzhizszN M1HuS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
NALM-6 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJzLkG5Olch|ryP M362[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
DOHH-2 NYD2XldLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDsWJVKSzVyPUKxMlQ5OTNizszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
EW-16 MkHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nxTmlEPTB;MkKuNVQxOiEQvF2= M4PCRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
A4-Fuk Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJ{LkKxOFkh|ryP MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
HD-MY-Z NUH5Tmt[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK4S5BKSzVyPUKyMlM6PjVizszN MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
SKM-1 NVPnfYFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH2xUXBKSzVyPUKyMlc{PTFizszN NFjLOmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
DMS-153 MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3UcHdEUUN3ME2yN{41OjB2IN88US=> NHnTWW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
LB373-MEL-D M3XLc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDtTWM2OD1{Mz61OFUzKM7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
LP-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIntcpJKSzVyPUKzMlgxQTdizszN MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
GI-ME-N NUThXnRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni4TWM2OD1{ND6yPVIh|ryP M13VPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
MPP-89 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ3LkKwN|Yh|ryP M{PiVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
U-698-M NX\5d4IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DweWlEPTB;MkWuNlUxOyEQvF2= NV7xWHR1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
HC-1 M{DJeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrlOIgzUUN3ME2yOU43PDF6IN88US=> NEHQe5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
HCC2157 NVnONXd3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHBTWM2OD1{NT62O|Mh|ryP Mo\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
MOLT-4 M{TjUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTJ4LkK3N{DPxE1? NX60W5VyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
LS-411N Mon2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJ4LkOzOlkh|ryP M1;hVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
Becker MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\lTWM2OD1{Nj61NVgyKM7:TR?= MkfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
NCI-H23 M{HLS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXtSZlKSzVyPUK2Mlc2PzVizszN M13Z[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
IST-SL1 M1r1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\3TWM2OD1{Nz6zPFY4KM7:TR?= Mk\oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
MZ2-MEL MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPVTWM2OD1{Nz60OVY3KM7:TR?= NXvaS3FjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
RKO NHjDcnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJ6LkG0OFYh|ryP NIr6N209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
TE-441-T MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTJ6Lke4PUDPxE1? M4f1O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
EW-24 NF;2b4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnLdIdFUUN3ME2yPU4yOjV7IN88US=> MoGzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
no-10 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFP6cY5KSzVyPUK5MlE3OzFizszN M4TyTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
D-542MG NGTZ[GRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HSXWlEPTB;MkmuPVIzOSEQvF2= MnnmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
ST486 M4i0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrBbFlKSzVyPUOwMlY1PTFizszN MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
KURAMOCHI NYftXXAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTNyLkiwOVch|ryP Mn3yQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
ES8 NWLGT2x6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTNzLkW5O|Ih|ryP MlXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
BL-41 NX61V3FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe1fJFKSzVyPUOyMlExPTRizszN MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
NB6 M4HQ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPTTWM2OD1|Mj6zPFU2KM7:TR?= NG\scok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
NCI-H1304 NUHodWlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;iO2t1UUN3ME2zNk41QTZ5IN88US=> Mly0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
MS-1 NXzjeo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXiwUpNxUUN3ME2zNk44PzVzIN88US=> M{LoXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
MFH-ino M3W3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn4ZVlSUUN3ME2zOE4{OjJ2IN88US=> NX61cZFXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
NOS-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTN2Lk[3OFgh|ryP NFTvcmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
HUTU-80 NGnqTpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTN3LkO2Olch|ryP MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
EB2 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoOzTWM2OD1|Nj62NVg6KM7:TR?= MmPWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
L-540 Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTN5LkKzNFgh|ryP MoLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVU1Nyd-U1HOS2VTRC:jPh?=
NCI-H747 NVrXXVlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPnbXJKSzVyPUO4Mlg5PDZizszN NYr2SplJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTV2Lze+V2FPT0WUPD;hQi=>
NCI-H446 Mn;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIKzRXRKSzVyPUO5Mlk3PTFizszN NH7qXWE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
MOLT-16 NI\y[|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPqfppKSzVyPUSyMlQyPSEQvF2= M{mzTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
BC-3 NGXJTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml24TWM2OD12NT60PFk3KM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
SJSA-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTBNW1KSzVyPUS1MlU1PzRizszN M1XPNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU2PC9pPmPBUmdGWjxxYU6=
BB65-RCC M33BVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHL3blFKSzVyPUS1MlY3PiEQvF2= NF3XO5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PTRxJ{7TRW5ITVJ:L3G+
SNB75 M1vQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDITWM2OD12Nj6wNVgh|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1OVQwLz6VQV7HSXI9N2F-
SKBR3 M1jVWmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIzKGK7IILld4F7fXKrbjDkfYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyIE2gNE4xODJizszNMi=> M{\CfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
SKOV3 M1LJU2N6fG:2b4jpZ4l1gSCjc4PhfS=> NXXXb2J4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochUEWUMjDifUBz\XOjeoXybY4h\HmnIILl[JVkfGmxbjDhd5NigSxiSVO1NEA:KDBwMECzJO69VS5? MnrHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjFyOEC2NlkoRjJzMEiwOlI6RC:jPh?=
CAL27 MkXlR5l1d3SxeHnjbZR6KGG|c3H5 NFXEVYFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBESUx{NzDj[YxteyCxdnXy[ZhxemW|c3nu[{BGT0[UIHL5JJJme2G8dYLpckBlgWVicnXkeYN1cW:wIHHzd4F6NCCLQ{WwJF0hOC5yMEeg{txONg>? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTB6ME[yPUc,OjFyOEC2Nlk9N2F-
4T1 M4C2TGN6fG:2b4jpZ4l1gSCjc4PhfS=> NV[zUZNjS3m2b4TvfIlkcXS7IHHnZYlve3RibX;1d4UhfHKrcHzlJI5m\2G2aY\lJFRVOSClZXzsd{whUUN3MDC9JFAvODFyM{eg{txONg>? NFvwWXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
MCF7 MULDfZRwfG:6aXPpeJkh[XO|YYm= M4G1XVQ5KGi{cx?= M3i4[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvODFzIN88UU4> M3:1dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MUWxOVgzLz5{NUG1NVU5OjxxYU6=
SKBR3 M1vIdWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3zVXVczKGi{cx?= NYjE[nN1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uEUkOgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMEG3JO69VS5? Mk\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyMki0NlUoRjF7MEK4OFI2RC:jPh?=
MDA-MB-231 NHfk[4pEgXSxdH;4bYNqfHliYYPzZZk> NGXrTXJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckB1emmybHWgcoVo[XSrdnWgUWRCNU2ELUKzNUBk\WyuczygTWM2OCB;IECuNFIh|ryPLh?= NEjhb3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEi5NFY2Oid-MkS4PVA3PTJ:L3G+
BT474 MofjRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUm3XGg{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFdmIzNCCLQ{WwJF0hOC5yMkWg{txONg>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ3M{OzN{c,OTh4NUOzN|M9N2F-
BT474 NHTufndCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M{HJOlczKGi{cx?= NYTJdXhySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{Bi\nSncjC3NkBpenNiYomgcYV1cHmuZX7lJIJtfWVic4ThbY5qdmdvYnHz[YQhdWW2aH;kMEBKSzVyIE2gNE4xOjVizszNMi=> MlTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF6OEe0NFMoRjJzOEi3OFA{RC:jPh?=
HEK293 M1juRmZ2dmO2aX;uJIF{e2G7 MkG0TY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCFLYTldo1qdmGuIFjpd{11[WepZXSgSWdHWiBqMTD0c{A3PDVicnXzbYR2\XNrIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkCyO|A3KM7:TT6= MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDdzMUewN{c,Ojh5MUG3NFM9N2F-
HEK293 M4P2XGZ2dmO2aX;uJIF{e2G7 MVzJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKE5vdHXycYlv[WxiSHnzMZRi\2enZDDFS2ZTKChzIITvJFY1PSC{ZYPp[JVmeyliZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMEK3NUDPxE1w MkX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MkG1O|MoRjJ7NEKxOVc{RC:jPh?=
HepG2 NW\VXZh[TnWwY4Tpc44h[XO|YYm= MkPGTY5pcWKrdHnvckBw\iCHR1\SJIlvKGi3bXHuJGhmeEd{IHPlcIx{NCCLQ{WwJF0hOC5yMkexJO69VS5? MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7NkW4NEc,OzByOU[1PFA9N2F-
SKBR3 MkXPR5l1d3SxeHnjbZR6KGG|c3H5 NUfQU|BNPzJiaILz M2C5UGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNMSlJ|IHPlcIx{KGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAxNjB{OTFOwG0v NH\CPJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi4PFc3OSd-MUm4PFg4PjF:L3G+
SKBR3 M2rKfGN6fG:2b4jpZ4l1gSCjc4PhfS=> Moi0O|IhcHK| MXPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTT2JTOyClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISXIuOiCpZX7lJIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCwMlAzQSEQvF2u MmS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|N{K4OlQoRjJ{M{eyPFY1RC:jPh?=
MDA-MB-435 MWrDfZRwfG:6aXPpeJkh[XO|YYm= NV21VHFYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ{PSClZXzsd{whUUN3MDC9JFAvODJ7NzFOwG0v MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
SKBR3 MYXDfZRwfG:6aXPpeJkh[XO|YYm= NEXMNY84OiCqcoO= NGLwd3VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBUU0KUMzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHyg[5Jwf3SqIHHmeIVzKDd{IHjyd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBKSzVyIE2gNE4xOzBzIN88UU4> MmfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MEWzN|AoRjJ3M{C1N|MxRC:jPh?=
BT474 M4XFcmN6fG:2b4jpZ4l1gSCjc4PhfS=> MVu3NkBpenN? Mon6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRnQ1PzRiY3XscJMh\XiycnXzd4lv\yCKZYKyJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkh[2WubDD0bZRmei2pbH:gcJVucW6nc3PlcoNmKGG|c3H5MEBKSzVyIE2gNE4xOzFizszNMi=> NYnCNZY2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkeyPFgyQDBpPkK3Nlg5OThyPD;hQi=>
CAL27 NWX0WlM2TnWwY4Tpc44h[XO|YYm= MkSxNVYhcHK| M1v4ZWlvcGmkaYTpc44hd2ZiRVfGMYlv\HWlZXSgSWdHWiCyaH;zdIhwenmuYYTpc44hcW5iaIXtZY4hS0GOMkegZ4VtdHNib4\ldoV5eHKnc4PpcochTUeIUjDh[pRmeiBzNjDodpMh[nliV3XzeIVzdiCkbH;0MEBKSzVyIE2gNE4xOzJizszNMi=> M4jOeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
NCI-N87 MWfDfZRwfG:6aXPpeJkh[XO|YYm= NX3JdHdEPzJiaILz NHjGbWtEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvTki3JINmdGy|IHX4dJJme3OrbnegTGVTNTJiYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDBwMEO2JO69VS5? MmrLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|N{K4OlQoRjJ{M{eyPFY1RC:jPh?=
insect cells M1;MfWZ2dmO2aX;uJIF{e2G7 M{TxSlUhdWmwcx?= NYm2WXhMUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBpfW2jbjDFS2ZTKEx6NUjSJI12fGGwdDDlfJBz\XO|ZXSgbY4h[mGldXzveolzfXNiaX7m[YN1\WRiaX7z[YN1KGOnbHzzJJBz\WmwY4XiZZRm\CCob4KgOUBucW6|IH\vcIxwf2WmIHL5JGFVWCCjZHTpeIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiM{CgcYlveyCkeTDIWHJHKGG|c3H5MEBKSzVyIE2gNE4xOzd3NTFOwG0v Ml[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByOU[1PFAoRjNyMEm2OVgxRC:jPh?=
SK-BR-3 NHfiR5VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFnoZolCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLMWJTNTNiY3XscJMh[W[2ZYKgbJJ{KGK7IFHUVEBkd262ZX70JIF{e2G7LDDJR|UxKD1iMD6wOEDPxE1w Ml7rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
MDA-MB-175 MnLnR5l1d3SxeHnjbZR6KGG|c3H5 MnfRO|IhcHK| MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMUe1JINmdGy|IHX4dJJme3OrbnegV5JkNCCUZYSgZY5lKGyxdzDISXIuOiCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOC5yNES0JO69VS5? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ|N{K4OlQ9N2F-
A431 NH3vXYNHfW6ldHnvckBie3OjeR?= NUDSUZh2UW6qaXLpeIlwdiCxZjDFS2ZTKGmwdILhZ4VtdHWuYYKgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIFG0N|Eh[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlA2OiEQvF2u MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN2Nk[1OUc,OjB|NE[2OVU9N2F-
SK-BR-3 M4LzcGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NW\XcZJJPDhiaILz Mmj3RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVSz3CVk0{KGOnbHzzJIV5eHKnc4PpcochUEWUMjDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhdWWjc4Xy[YQh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvODZizszNMi=> NHrCXVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2PVY4OSd-Mke3Olk3PzF:L3G+
BT474 MVjDfZRwfG:6aXPpeJkh[XO|YYm= NEjFVWw4OiCqcoO= MWPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDJR|UxKD1iMD6wOlM6KM7:TT6= NWOyT2FIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N|A2OzNyPD;hQi=>
MCF7 M13ITGN6fG:2b4jpZ4l1gSCjc4PhfS=> NHi0eVhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBGWi2yb4PpeIl3\SCPQ1[3JINmdGy|LDDJR|UxKD1iMD6wOlQ6KM7:TT6= MnjXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR6OUC2OVIoRjJ2OEmwOlUzRC:jPh?=
MDA-MB-468 NEDPZW5EgXSxdH;4bYNqfHliYYPzZZk> MmHLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6geJJqeGynIH7l[4F1cX[nIF3ERU1OSi12NkigZ4VtdHNuIFnDOVAhRSByLkC4N|Ih|ryPLh?= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDh7ME[1Nkc,OjR6OUC2OVI9N2F-
NCI-N87 M{npcWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUniN|FROyCmYYnz M2S0e2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMW45PyClZXzsd{Bi\nSncjCzJIRigXNiYomgcYV1cHmuZX7lJIJtfWVic4ThbY5qdmduIFnDOVAhRSByLkC5JO69VS5? NIL0N2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNVE{Oid-MkKxNFEyOzJ:L3G+
N87 NGXkXXVHfW6ldHnvckBie3OjeR?= NWfYW2N4UW6qaXLpeIlwdiCxZjDFdoJDOiCrboTyZYNmdGy3bHHyJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDOPFch[2WubIOgZpkhTUyLU1GsJGlEPTBiPTCwMlEh|ryPLh?= NYK4ZWFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOFY3PTVpPkKwN|Q3PjV3PD;hQi=>
BT474 NFzxUXdCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmqyN{Bl[Xm| M{XHNWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQmS0O|Qh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IH3leIh6dGWwZTDicJVmKHO2YXnubY5oNCCLQ{WwJF0hOC5zIN88UU4> NH3GU5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNVE{Oid-MkKxNFEyOzJ:L3G+
Calu3 NFjEWZZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1:4WVczKGi{cx?= NVKyVZNwSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDZYx2OyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNE4yKM7:TT6= M{O5OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEmyPFYxLz5{OEC5Nlg3ODxxYU6=
BT474 MmnmR5l1d3SxeHnjbZR6KGG|c3H5 NEjabVc1QCCqcoO= M4nBNWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJVPDd2IHPlcIx{KGW6cILld5NqdmdiSFXSNkBie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHlibXXhd5Vz\WRiYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMTFOwG0v M2G0VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{[5OlcyLz5{N{e2PVY4OTxxYU6=
A431 MVvDfZRwfG:6aXPpeJkh[XO|YYm= M3vwU|czKGi{cx?= M1vXXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFAvOTB2IN88UU4> NV\Wd4VoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4PFg4PjFpPkG5PFg5PzZzPD;hQi=>
A431 MoXHR5l1d3SxeHnjbZR6KGG|c3H5 MX:3NkBpenN? M1zUd2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegTGVTNTFiZ3Xu[UBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gNE4yODRizszNMi=> MlXZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|N{K4OlQoRjJ{M{eyPFY1RC:jPh?=
HeLa NGHM[mFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFzOZWMyOiCqcoO= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhOTJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDBwMUKg{txONg>? MlzIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK0PFIoRjJ4NkWyOFgzRC:jPh?=
MIAPaCa MWLGeY5kfGmxbjDhd5NigQ>? MlvsTY5pcWKrdHnvckBw\iCHUlLiNkBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gUWlCWGGFYTDj[YxteyCkeTDFUGlUSSxiSVO1NEA:KDBwMUSg{txONg>? MnPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6MUe1NlMoRjJyOEG3OVI{RC:jPh?=
A431 NH74RXlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MUC0PEBpenN? MonmRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEOxJINmdGy|IHX4dJJme3OrbnegSWdHWi:KRWKyJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCvZXHzeZJm\CCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOC5zNTFOwG0v MnHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5Nkm2O|EoRjJ5N{[5OlcyRC:jPh?=
MDA-MB-453 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NVLFXmRSPzJiaILz MmnhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUS1N{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHPlcIwh\3Kxd4ToJIFnfGW{IEeyJIhzeyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCLQ{WwJF0hOC5zOTFOwG0v NUD6OVdWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N|A2OzNyPD;hQi=>
BT474 MYnDfZRwfG:6aXPpeJkh[XO|YYm= MYm3NkBpenN? MU\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCWFQ4PCClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2GuY3Xpck1CVSCmeXWgZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDHTVUxKD1iMD6yJO69VS5? MlrRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyOVkoRjJ7MEi5NlU6RC:jPh?=
B16F10 NYTFN4p2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MX:xNkBpenN? NVvkNmhWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDCNVZHOTBiY3XscJMh[W[2ZYKgNVIhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvOjFizszNMi=> Mlj0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK0PFIoRjJ4NkWyOFgzRC:jPh?=
Sf21 NHzse49HfW6ldHnvckBie3OjeR?= NV7uXmVXPSCvaX7z NEDvSWJKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygS3NVNXSjZ3fl[EBz\WOxbXLpcoFvfCCqdX3hckBGT0[UIGS3PVBOKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4YzOSCrboPlZ5Qh[2WubIOgdJJmcW6ldXLheIVlKG[xcjC1JI1qdnNiZn;scI94\WRiYomgRXRRKGGmZHn0bY9vKGGwZDDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGK7IFjUVmYh[XO|YYmsJGlEPTBiPTCwMlIzPDh7IN88UU4> M3HxelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEm2OVgxLz5|MEC5OlU5ODxxYU6=
Calu3 NX3tcXlQS3m2b4TvfIlkcXS7IHHzd4F6 NGjW[5Y4OiCqcoO= NUnDNZVUS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hS2GudUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDh[pRmeiB5MjDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFAvOjNizszNMi=> NGLnT249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
DIFI MYnDfZRwfG:6aXPpeJkh[XO|YYm= NFXDS|A1KGSjeYO= NGfadJNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFUU[LIHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFAvOjN3IN88UU4> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
HepG2 MmHMRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXP5dZl5OTJiaILz NELwUXVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEGyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlI4KM7:TT6= MmjqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4NUK0PFIoRjJ4NkWyOFgzRC:jPh?=
EOL-1 NXPjOFNlS3m2b4TvfIlkcXS7IHHzd4F6 NYrKN2xkPzJiaILz MmHaR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSW9NNTFiY3XscJMh[XO|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KGOjbHPlbY4uSU1iZInlJIJie2WmIH\seY9z\XOlZX7j[UBie3OjeTygS2k2OCB;IECuOFEh|ryPLh?= MnLUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyOEmyOVkoRjJ7MEi5NlU6RC:jPh?=
MIAPaCa M3TWTmZ2dmO2aX;uJIF{e2G7 NEj1SndKdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJG1KSVCjQ3GgZ4VtdHNiYomgSWxKW0FuIFnDOVAhRSByLkSzN{DPxE1w NGnOVHI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEixO|UzOyd-MkC4NVc2OjN:L3G+
MCF7 NUPmeoF4SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NF;WUnYyOiCqcoO= MnzaRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHmeIVzKDF{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSByLkS3JO69VS5? NHHoNY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[1NlQ5Oid-Mk[2OVI1QDJ:L3G+
SKBR3 Ml[0RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NWXVfm9IPDhiaILz MnPKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCVS1LSN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMD60PUDPxE1w MoO4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzOEe4OVYoRjJ5MUi3PFU3RC:jPh?=
A549 NIfEdWVEgXSxdH;4bYNqfHliYYPzZZk> NF7qUmk1QCCqcoO= MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIV5eHKnc4PpcochTUeIUjDhcoQhU1KDUzDteZRidnRiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGOnbHygeoli[mmuaYT5JI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCwMlUyKM7:TT6= NHThPYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e2PVY4OSd-Mke3Olk3PzF:L3G+
CAL27 MYHDfZRwfG:6aXPpeJkh[XO|YYm= NVzSfYh3PCCmYYnz M{KzRmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGNCVDJ5IHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFAvPTNizszNMi=> M1jXdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
MDA-MB-453 MVvDfZRwfG:6aXPpeJkh[XO|YYm= NV7Xe5hOPzJiaILz MmK0R5l1d3SxeHnjbZR6KGGpYXnud5QhWFSHTj3k[YZq[2mnboSgbJVu[W5iTVTBMW1DNTR3MzDj[YxteyCneIDy[ZN{cW6pIFjFVk0zNCCjbnSgVGlMO0ODIH31eIFvfCCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOC53NUWg{txONg>? MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ|N{K4OlQ9N2F-
SKOV3 MlmxR5l1d3SxeHnjbZR6KGG|c3H5 MoHlO|IhcHK| NX3aPXk1S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iClZXzsJIdzd3e2aDDh[pRmeiB5MjDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhUUN3MDC9JFAvPTlizszNMi=> M2TJ[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N|MxLz5{NUOwOVM{ODxxYU6=
HCC827 M4PlUGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlfxO|IhcHK| NWrybGRJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIR2M5OjdiY3XscJMhcGG{Yn;ybY5oKEWJRmKgSVc1Pi2DN{WwJIRmdCCvdYThcpQh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFAvPiEQvF2u MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{MUW3N{c,Ojl2MkG1O|M9N2F-
A431NS MUjBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mo\vO|IhcHK| Ml\SRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNEOxUnMh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IECuOkDPxE1w NGjoXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5Nlg3OCd-MkiwPVI5PjB:L3G+
A431 NVjpO2d2S3m2b4TvfIlkcXS7IHHzd4F6 MVG3NkBpenN? NIPiNlBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPDNzIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[2WubDDndo94fGhiYX\0[ZIhPzJiaILzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGlEPTBiPTCwMlY1OzFizszNMi=> NY\jN2ZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNFU{OzBpPkK1N|A2OzNyPD;hQi=>
BT474 MlrnR5l1d3SxeHnjbZR6KGG|c3H5 NGDTS4I4OiCqcoO= MkDyR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRnQ1PzRiY3XscJMh\XiycnXzd4lv\yCKRWKyJIFnfGW{IEeyJIhzeyCkeTDD[YxtKFSrdHXyJGdtdyCjc4PhfUwhT0l3MDC9JFAvQTNizszNMi=> NYW4d5ZuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[0O|U2OjBpPkK2OFc2PTJyPD;hQi=>
A431 Moj2R5l1d3SxeHnjbZR6KGG|c3H5 MlHMR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVQ{OSClZXzsd{BwfmW{ZYjwdoV{e2mwZzDFS2ZTKGK7IILld4F7fXKrbjDkfYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyIE2gNE46PyEQvF2u NIf2doI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
MDA-MB-361 M1\LUGN6fG:2b4jpZ4l1gSCjc4PhfS=> NGnIcoI4OiCqcoO= NYrQco9RS3m2b4TvfIlkcXS7IHHnZYlve3RiRWKgZYN1cX[jdHXkJIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNiZYjwdoV{e2mwZzDI[ZIuOixiU4LjJIFv\CCSSVuzR2EhdXW2YX70JIFnfGW{IEeyJIhzeyCkeTDTVmIh[XO|YYmsJGlEPTBiPTCxMlAzQSEQvF2u MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ|N{K4OlQ9N2F-
GXF251L M13tTWN6fG:2b4jpZ4l1gSCjc4PhfS=> M4nQZVQh\GG7cx?= NHLLXo5EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBIYEZ{NUHMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDFwNEig{txONg>? NULHcZprRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
A431 MoGyRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnftO|IhcHK| NX7GO2l{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzJI93\XKneIDy[ZN{cW6pIFXHSnIh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFIvPiEQvF2u MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7NUG3O{c,OjJ3OUWxO|c9N2F-
A431 MkfZR5l1d3SxeHnjbZR6KGG|c3H5 NIW2XoM4OiCqcoO= M3jadGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMhd3[ncnX4dJJme3OrbnegSWdHWiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOi54MjFOwG0v NX2yW|JnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxPFI2QDFpPkKyNVgzPThzPD;hQi=>
LXFA 629L MWPDfZRwfG:6aXPpeJkh[XO|YYm= NH;KRYE1KGSjeYO= NYG1Z21OS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVFiIQTC2NllNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OCB;IEKuPFch|ryPLh?= NWK2TGpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
DU145 NWnITHJjS3m2b4TvfIlkcXS7IHHzd4F6 M{LCbVQh\GG7cx?= NXvINmhFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwJF0hOi57OTFOwG0v Ml3HQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
SKOV3 NV3lcHBTS3m2b4TvfIlkcXS7IHHzd4F6 MYW3NkBpenN? NVjWTpVYS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW0uRVkOgZ4VtdHNib4\ldoV5eHKnc4PpcochTXKkQkKgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEKuPVkh|ryPLh?= M4jaPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUiyOVgyLz5{MkG4NlU5OTxxYU6=
NCI-H1781 MX;DfZRwfG:6aXPpeJkh[XO|YYm= M2HNNVczKGi{cx?= NI\EXWZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEG3PFEh[2WubIOg[ZhxemW|c3nu[{BJTVJvMjDHO|c3cW6|Vm;HM2Mh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3MDC9JFMvODR5IN88UU4> MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN5Mki2OEc,OjJ|N{K4OlQ9N2F-
OVXF 899L MoPtR5l1d3SxeHnjbZR6KGG|c3H5 M1fNZVQh\GG7cx?= MlnxR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gU3ZZTiB6OUnMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDNwM{Wg{txONg>? M4LIOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
LXFL 529L MkDCR5l1d3SxeHnjbZR6KGG|c3H5 M3PtNFQh\GG7cx?= M3PWVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxZTkxiNUK5UEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSB|LkWxJO69VS5? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
LNCAP NEW5WJREgXSxdH;4bYNqfHliYYPzZZk> M{TYPFQh\GG7cx?= MnrjR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gN{43QCEQvF2u MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
Bel7402 NYf6OWNjSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3LudFczKGi{cx?= Mn\ERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCEZXy3OFAzKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCzMlch|ryPLh?= NFPl[3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5Nlg3OCd-MkiwPVI5PjB:L3G+
LXFA 526L M2GzSmN6fG:2b4jpZ4l1gSCjc4PhfS=> MUS0JIRigXN? NUfjSnQyS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVFiIQTC1NlZNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OCB;IESuNlEh|ryPLh?= M3HHZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
NIH/3T3 M3TObGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXfkU4I2PzJiaILz NXPxRXp5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBud3W|ZTDOTWgwO1R|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA1NjNizszNMi=> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7NUG3O{c,OjJ3OUWxO|c9N2F-
SK-BR-3 NH\rbIlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NFLXb2hCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGVz[kJ{IH;2[ZJmgHC{ZYPzbY5oKGi3bXHuJHNMNUKULUOgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE4{PSEQvF2u M1f2fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUewPFQ{Lz5{MUW3NFg1OzxxYU6=
UXF 1138L Mm[5R5l1d3SxeHnjbZR6KGG|c3H5 M3v0V|Qh\GG7cx?= NGTNXZREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBWYEZiMUGzPGwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m|LDDJR|UxKD1iND60JO69VS5? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
SK-BR-3 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3yxdFczKGi{cx?= M2H3fmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iU1utRnIuOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gOE41KM7:TT6= MnHIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
PC3M MXjDfZRwfG:6aXPpeJkh[XO|YYm= NV63[ll2PCCmYYnz M{XpTWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBEO01iY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gOE42PSEQvF2u NYS3V49TRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
COLO205 M1\oXWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NUXVT2FoPzJiaILz NIXZfIlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFPPUG8zODViY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFQvPiEQvF2u M2D4cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MEmyPFYxLz5{OEC5Nlg3ODxxYU6=
HT-29 NHK3e2VEgXSxdH;4bYNqfHliYYPzZZk> M4OwXVQh\GG7cx?= NV;5d4V{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUFRvMkmgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwJF0hPC54MjFOwG0v MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
A431 M3rVN2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MlvCO|IhcHK| M3\5XGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDoZZJjd3Krbnege4lt\CC2eYDlJGVITlJiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NEA:KDRwODFOwG0v MnTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MkG1O|MoRjJ7NEKxOVc{RC:jPh?=
A431 NF\zWmJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGrVUo04OiCqcoO= NHLYblhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0N|Eh[2WubIOgbIFz[m:{aX7nJJdqdGRidInw[UBGT0[UIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVAhRSB2Lkig{txONg>? MoPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MUG3NFMoRjJ6N{GxO|A{RC:jPh?=
A431 NGXxPZlEgXSxdH;4bYNqfHliYYPzZZk> NUWyfIx[PzJiaILz M3H1WGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE1OzFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVe1NEA:KDRwODFOwG0v MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ|OE[xOEc,Ojh{M{i2NVQ9N2F-
MCF7 MXXDfZRwfG:6aXPpeJkh[XO|YYm= NIq1Wos1KGSjeYO= M1\5bGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gOE45OyEQvF2u NUfxZlRVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
MEXF 1341L NHfiTo1EgXSxdH;4bYNqfHliYYPzZZk> MYK0JIRigXN? MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSXhHKDF|NEHMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDRwOEWg{txONg>? MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
MCF7 M4PYSmN6fG:2b4jpZ4l1gSCjc4PhfS=> MljLNlQhcHK| MnvLR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgV3JDKGG|c3H5MEBKSzVyIE2gOU4xOiEQvF2u NGHBfHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
SKBR3 MnWwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MorDO|IhcHK| MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKGW|dILv[4VvKHKnY3XweI9zKGGwZDDwdo9o\XO2ZYLvcoUhemWlZYD0c5Ih\GWoaXPp[Y51KFONQmKzJINmdGy|IHX4dJJme3OrbnegTGVTOiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPS5yNTFOwG0v MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl{N{m3Nkc,OjN7Mke5O|I9N2F-
SKHEP1 NX7nb4ZGSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NGHRWGlpenN? NGTX[YhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPLTGVROSClZXzsd{Bi\nSncjDodpMh[nliQWTQJINwdnSnboSgZZN{[XluIFnDOVAhRSB3LkOg{txONg>? MlrRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzNEO3O|goRjJyMUSzO|c5RC:jPh?=
RKO NETHOZpEgXSxdH;4bYNqfHliYYPzZZk> Mm\mOEBl[Xm| NYjVeVZsS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWkuRIHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFUvOzVizszNMi=> Mlz1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
MDA-MB-231 NXnMcoI6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXvodpM> NXLtZpl1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKGi{czDifUBCXFBiY3;ueIVvfCCjc4PhfUwhUUN3MDC9JFUvPCEQvF2u NXGxTWtwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
Hep3B2 M3H3RWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkSxbJJ{ M1vH[2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSHXwN2IzKGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NEA:KDVwNEmg{txONg>? NYrMOoY4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
K562 M4HDSmN6fG:2b4jpZ4l1gSCjc4PhfS=> NFL5R2s4OiCqcoO= MmW3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bie3Onc4Pl[EBieyCpcn;3eIghcW6qaXLpeIlwdiCjZoTldkA4OiCqcoOgZpkh[2GuY3Xpck1CVSCmeXWgZoF{\WRiZnz1c5Jme2OnbnPlJIF{e2G7LDDHTVUxKD1iNT63JO69VS5? NX72XHdRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwPFkzPTlpPkK5NFg6OjV7PD;hQi=>
LXFA 289L MkPiR5l1d3SxeHnjbZR6KGG|c3H5 NUPiUHV3PCCmYYnz NHfZUnVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNYE[DIEK4PWwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m|LDDJR|UxKD1iNT63PUDPxE1w MnXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
MAXF 401NL NYrNWZI2S3m2b4TvfIlkcXS7IHHzd4F6 MXW0JIRigXN? MkLuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWFZTiB2MEHOUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSB3Lkig{txONg>? MnvFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
HeLa NHe2WmFEgXSxdH;4bYNqfHliYYPzZZk> Mor1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{BwfmW{ZYjwdoV{e2mwZzDISGFEKGK7IILld4F7fXKrbjDkfYUhemWmdXP0bY9vKGG|c3H5MEBKSzVyIE2gOU46KM7:TT6= NFm4OYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUC4NFYzQSd-MkGwPFA3Ojl:L3G+
HCT116 NXfvZ3A1S3m2b4TvfIlkcXS7IHHzd4F6 NXXTXZdGOjRiaILz NFrPbYpEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KFOUQjDhd5NigSxiSVO1NEA:KDVwOUKg{txONg>? NHfZeJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
22Rv1 M1LLO2N6fG:2b4jpZ4l1gSCjc4PhfS=> MUO0JIRigXN? M4XocmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJFIzWnZzIHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFYvODZizszNMi=> MnnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
PAXF 546L M1r2SGN6fG:2b4jpZ4l1gSCjc4PhfS=> M17lVlQh\GG7cx?= Mn\ER5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFZTiB3NE\MJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDZwMUKg{txONg>? MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
HCT116 MYXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NIjP[Ww4OiCqcoO= MXTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiFVEGxOkBk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iNj6yJO69VS5? MkPLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
HepG2 NXLvNmVMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MVTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHHmeIVzKGi{czDifUBCXFBiY3;ueIVvfCCjc4PhfUwhUUN3MDC9JFYvOjdizszNMi=> NWTuT3lRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOFM4PzhpPkKwNVQ{Pzd6PD;hQi=>
HepG2 M3zL[mN6fG:2b4jpZ4l1gSCjc4PhfS=> MVrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHluIGTDOVAhRSB4LkK3JO69VS5? M33iTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MES5PVY{Lz5{OUC0PVk3OzxxYU6=
HepG2 MXvDfZRwfG:6aXPpeJkh[XO|YYm= M3zVUGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhmeEd{IHPlcIx{NCCWQ{WwJF0hPi5|IN88UU4> M3T1WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{S0PVA3Lz5|MEO0OFkxPjxxYU6=
NCI-H522 M4D2emFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MmLkO|IhcHK| NWXpT5UxSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDV{MjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPi52IN88UU4> MoPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
MCF7 NI[yfHpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MofDbJJ{ NULYPG9mSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IHjyd{BjgSCDVGCgZ49vfGWwdDDhd5NigSxiSVO1NEA:KDZwNjFOwG0v NIXtUpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG0N|c4QCd-MkCxOFM4Pzh:L3G+
A549 NHjNOnFCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnywOFghcHK| NW[zOVhqSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC2Mlc1KM7:TT6= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6N{i1Okc,OjdzOEe4OVY9N2F-
MCF7 MknVRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MVy3NkBpenN? NVO1T41tSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC2Mlgh|ryPLh?= NWT1PIt1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFQ4ODhpPkK5Olg1PzB6PD;hQi=>
PXF 1118L NYru[mF7S3m2b4TvfIlkcXS7IHHzd4F6 MkHEOEBl[Xm| M1jz[GN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHBZTiBzMUG4UEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSB4Lki2JO69VS5? NVj6UnlWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
LIXF 575L MXjDfZRwfG:6aXPpeJkh[XO|YYm= NHvjfXE1KGSjeYO= MXfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMTXhHKDV5NVygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwJF0hPy5zODFOwG0v M4CwZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
RXF 1781L NWL3dZV7S3m2b4TvfIlkcXS7IHHzd4F6 MYK0JIRigXN? NGfoSYJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBTYEZiMUe4NWwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m|LDDJR|UxKD1iNz62O{DPxE1w NYX1R5BHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
MDA231 MUHDfZRwfG:6aXPpeJkh[XO|YYm= MWW0JIRigXN? NVjNVFdrS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDMkOxJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDdwNzFOwG0v NXzHXXRRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
LXFL 1121L Ml3BR5l1d3SxeHnjbZR6KGG|c3H5 NHviNFY1KGSjeYO= Mmj1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUHhHVCBzMUKxUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSB5LkezJO69VS5? M2XuZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
RXF 393NL NF3sXoxEgXSxdH;4bYNqfHliYYPzZZk> MnHaOEBl[Xm| M2jON2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHJZTiB|OUPOUEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSB5Lke3JO69VS5? MnH5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
MCF7 MoDHR5l1d3SxeHnjbZR6KGG|c3H5 NFu4[VA4OiCqcoO= MVTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KGe{b4f0bEBqdmirYnn0bY9vKGGodHXyJFczKGi{czDifUBk[WylZXnuMWFOKGS7ZTDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFfJOVAhRSB6LkGg{txONg>? NXvBbJBERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmwPFkzPTlpPkK5NFg6OjV7PD;hQi=>
PANC1 Mo\kR5l1d3SxeHnjbZR6KGG|c3H5 NHvObJQ1KGSjeYO= Ml:4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVGFPSzFiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gPE4yOiEQvF2u MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
CXF 269L MUTDfZRwfG:6aXPpeJkh[XO|YYm= NWXkXHlTPCCmYYnz NEPSXYdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBEYEZiMk[5UEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSB6LkO2JO69VS5? M4C0XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
NCI-H460 MV;BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWPnUWJ{PzJiaILz M3fjOmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg1PjBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3MDC9JFgvPCEQvF2u MlHpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyOUK4OlAoRjJ6MEmyPFYxRC:jPh?=
MCF7 MYTDfZRwfG:6aXPpeJkh[XO|YYm= MX:3NkBpenN? MknXR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJINmdGxiZ4Lve5RpKGGodHXyJFczKGi{czDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDJR|UxKD1iOD60Olgh|ryPLh?= NIDoW489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
A549 NELZZ5dEgXSxdH;4bYNqfHliYYPzZZk> NIPPUFhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJGhFSUNiYomgdoV{[Xq3cnnuJIR6\SC{ZXT1Z5Rqd25iYYPzZZktKEmFNUCgQUA5NjVizszNMi=> M2rHfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMEiwOlI6Lz5{MUC4NFYzQTxxYU6=
NCI-H1975 MoXXRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M3fNNVczKGi{cx?= MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INVk4PSClZXzsd{Bp[XKkb4LpcochTUeIUjDMPFU5Wi:WN{mwUUBufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEmuNFgh|ryPLh?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDdzMUewN{c,Ojh5MUG3NFM9N2F-
NCI-H1975 MmD3R5l1d3SxeHnjbZR6KGG|c3H5 NEDnUZI4OiCqcoO= NFizZoxEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBPS0lvSEG5O|Uh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUd3MDC9JFkvODhizszNMi=> NVP5RlJPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyN|g3OTRpPkK4NlM5PjF2PD;hQi=>
RXF 486L M3HpSWN6fG:2b4jpZ4l1gSCjc4PhfS=> NYDK[|huPCCmYYnz MmLuR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gVnhHKDR6NlygZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwJF0hQS5zIN88UU4> M4\vNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
Saos2 NIjzT5pEgXSxdH;4bYNqfHliYYPzZZk> NIPUflM1KGSjeYO= NUXGVVhXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hW2Gxc{KgZ4VtdHNiYX\0[ZIhPCCmYYnzJIJ6KHC{b4Dp[Il2dSCrb3Tp[IUhe3SjaX7pcocu[mG|ZXSg[ox2d3KxbXX0dolkKGGwYXz5d4l{NCCLQ{WwJF0hQS5|ODFOwG0v M4LSNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
PXF 1752L NELhPXJEgXSxdH;4bYNqfHliYYPzZZk> M2K5PFQh\GG7cx?= NGDMbnVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRYEZiMUe1Nmwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m|LDDJR|UxKD1iOT60OkDPxE1w MmqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
PXF 698L NEnPXGZEgXSxdH;4bYNqfHliYYPzZZk> NW\3NIptPCCmYYnz MWfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQXGYhPjl6TDDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUA6NjR7IN88UU4> MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
BXF T24 MX3DfZRwfG:6aXPpeJkh[XO|YYm= NF;Scmc1KGSjeYO= MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDCXGYhXDJ2IHPlcIx{KGGodHXyJFQh\GG7czDifUBxem:yaXTpeY0hcW:maXTlJJN1[WmwaX7nMYJie2WmIH\seY9zd22ndILpZ{BidmGueYPpd{whUUN3MDC9JFkvPjVizszNMi=> NFjvdmQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
HCT116 NUnWSXl2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkDEO|IhcHK| M2LS[GFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTCxNE4yOiEQvF2u NWfJRYlDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFQ4ODhpPkK5Olg1PzB6PD;hQi=>
MEXF 462NL MYLDfZRwfG:6aXPpeJkh[XO|YYm= MnnaOEBl[Xm| M3;PXmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1GYEZiNE[yUmwh[2WubIOgZYZ1\XJiNDDkZZl{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\my3b4LvcYV1emmlIHHuZYx6e2m|LDDJR|UxKD1iMUCuNVMh|ryPLh?= M{LaWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
A2780 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NI\6fZE4OiCqcoO= NVfTSm83SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBNlc5OCClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyIE2gNVAvPCEQvF2u NFrMZWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[4OFcxQCd-Mkm2PFQ4ODh:L3G+
TE671 NUjVSZUyS3m2b4TvfIlkcXS7IHHzd4F6 NFm1PGI1KGSjeYO= Mn7OR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWGU3PzFiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNVAvQTVizszNMi=> NF2xb|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
RAW264.7 MojyRY51cWynaYPocYFvcWGuIHHzd4F6 M1zNfFk3KGi{cx?= MY\BcpRqdGWrc3jtZY5q[WxiYXP0bZZqfHliYXfhbY5{fCCudXPp[oVz[XOnLXX4dJJme3OrbnegUIVqe2ivYX7pZUBu[WqxcjDhcYF{fGmpb4Tld{Bqdm[nY4Tl[EBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDh[pRmeiB7NjDodpMh[nlibIXtbY5me2OnbnPlJIF{e2G7LDDFR|UxKD1iMUGg{txONg>? M1O2WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O3N|I6Lz5{OEOzO|MzQTxxYU6=
PAXF 1657L NEXEPZBEgXSxdH;4bYNqfHliYYPzZZk> Mmm1OEBl[Xm| MUDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQRXhHKDF4NUfMJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDFzLkGxJO69VS5? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
MEXF 276L MW\DfZRwfG:6aXPpeJkh[XO|YYm= MmnQOEBl[Xm| Ml3jR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWVZTiB{N{\MJINmdGy|IHHmeIVzKDRiZHH5d{BjgSCycn;wbYRqfW1iaX;kbYRmKHO2YXnubY5oNWKjc3XkJIZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NEA:KDFzLkO3JO69VS5? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
MKN45 MWXDfZRwfG:6aXPpeJkh[XO|YYm= NXfjfmZqPCCmYYnz NIeyS4VEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOU052NTDj[YxteyCjZoTldkA1KGSjeYOgZpkheHKxcHnkbZVuKGmxZHnk[UB{fGGrbnnu[{1j[XOnZDDmcJVwem:vZYTybYMh[W6jbInzbZMtKEmFNUCgQUAyOS52ODFOwG0v MnPDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNkm2NFEoRjJ{MU[5OlAyRC:jPh?=
BXF 1352L MYnDfZRwfG:6aXPpeJkh[XO|YYm= MorsOEBl[Xm| NYO1VHk2S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSliIIEGzOVJNKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OCB;IEGxMlU{KM7:TT6= MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF4OU[wNUc,OjJzNkm2NFE9N2F-
HepG2 MVrDfZRwfG:6aXPpeJkh[XO|YYm= MYGyOEBpenN? NF7DbVNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJ\XCJMjDj[YxteyCjZoTldkAzPCCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwJF0hOTFwN{Gg{txONg>? NHLBcpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEC5OlU5OCd-M{CwPVY2QDB:L3G+
BXF 1218L NW[zR5lTS3m2b4TvfIlkcXS7IHHzd4F6 M2fBdlQh\GG7cx?= M{HvVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGJZTiBzMkG4UEBk\WyuczDh[pRmeiB2IHThfZMh[nlicILvdIllcXWvIHnv[Ill\SC|dHHpcolv\y2kYYPl[EBndHWxcn;t[ZRzcWNiYX7hcJl{cXNuIFnDOVAhRSBzMT63O{DPxE1w NInxPW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG2PVYxOSd-MkKxOlk3ODF:L3G+
Caco Ml\QR5l1d3SxeHnjbZR6KGG|c3H5 M2LNelI1KGi{cx?= NGL6[WZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBE[WOxIHPlcIx{KGGodHXyJFI1KGi{czDifUBUWkJiYYPzZZktKEmFNUCgQUAyOi5zMTFOwG0v MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB7NkW4NEc,OzByOU[1PFA9N2F-
SW480 MYLBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3jsVFczKGi{cx?= MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOZNEiwJINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgSWdHWiCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOTJwNUig{txONg>? NX[3PGd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NlE2PzNpPkK5OFIyPTd|PD;hQi=>
SW480 MoiwRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGH3RXI4OiCqcoO= NH\4fo1CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGPXOFgxKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhTUeIUjDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUKuOVgh|ryPLh?= NXGxUZFjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3NVE4ODNpPkK4O|EyPzB|PD;hQi=>
SW480 M3Oz[GN6fG:2b4jpZ4l1gSCjc4PhfS=> NEeyVFA4OiCqcoO= MnrKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gV3c1QDBiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVe1NEA:KDF{LkW4JO69VS5? M1OzSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkO4OlE1Lz5{OEKzPFYyPDxxYU6=
NCI-H1975 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3qyVVczKGi{cx?= Mn\qRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFE6PzViY3XscJMhcGG{Yn;ybY5oKEWJRmKgUFg2QFJxVEe5NG0h\G:3YnzlJI12fGGwdDDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUKuOlgh|ryPLh?= NIDIVHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSyNVU4Oyd-Mkm0NlE2PzN:L3G+
3T3 NVXGR5dYSW62aYTyfZBidm:|b33hcEBie3OjeR?= M1HJUlQ5KGi{cx?= MlzJRY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTDh[4FqdnO2IGTyfZBidm:|b33hJINzfXqrIGT1cIFpfWWwIHHtZZN1cWexdHXzJIlv\mWldHXkJIlvKHKjdDCzWFMh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IHPocI9zd3CqZX7vcEBz\WRvYnX0ZU1FNWejbHHjeI9xgXKjbn;zbYRmKGKjc3XkJIF{e2G7LDDFR|UxKD1iMUOg{txONg>? M2LjUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{O3N|I6Lz5{OEOzO|MzQTxxYU6=
HCT116 NYLxR2JpS3m2b4TvfIlkcXS7IHHzd4F6 M2izW|Qh\GG7cx?= MWTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNVMvOTRizszNMi=> M{DGblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
OVCAR3 M2jtVGN6fG:2b4jpZ4l1gSCjc4PhfS=> M4j1Z|Qh\GG7cx?= MVXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDPWmNCWjNiY3XscJMh[W[2ZYKgOEBl[Xm|IHL5JJBzd3CrZHn1cUBqd2SrZHWgd5RicW6rbnetZoF{\WRiZnz1c5JwdWW2cnnjJIFv[Wy7c3nzMEBKSzVyIE2gNVMvPDRizszNMi=> NVfDS3Z5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOlk3ODFpPkKyNVY6PjBzPD;hQi=>
H460 NWKx[pFDS3m2b4TvfIlkcXS7IHHzd4F6 MmToOEBl[Xm| MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIOFYxKGOnbHzzJIFnfGW{IESg[IF6eyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[udX;yc41mfHKrYzDhcoFtgXOrczygTWM2OCB;IEGzMlQ3KM7:TT6= M4PvUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MU[5OlAyLz5{MkG2PVYxOTxxYU6=
A549 NEmwVWJCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWG3NkBpenN? MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiaHHyZo9zcW6pIIfpcIQhfHmyZTDFS2ZTN0tvcnHzJI12fGGwdDDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxKD1iMUSuPUDPxE1w M4i5R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEKxOVc{Lz5{OUSyNVU4OzxxYU6=
A549 MUDBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFTBWY44OiCqcoO= MoPMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHjhdoJwemmwZzD3bYxlKHS7cHWgSWdHWi:NLWLhd{BufXSjboSgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OCB;IEG0Mlkh|ryPLh?= MoTMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5MUG3NFMoRjJ6N{GxO|A{RC:jPh?=
A549 NIrmXotEgXSxdH;4bYNqfHliYYPzZZk> MkHHO|IhcHK| NFPnXVdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnHOVAhRSBzND65JO69VS5? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ|OE[xOEc,Ojh{M{i2NVQ9N2F-
MCF7 MoK4R5l1d3SxeHnjbZR6KGG|c3H5 M1yxZVQ5KGi{cx?= MoL1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BmgHC{ZYPzbY5oKHClRF7BN{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUCgQUAyPS55MTFOwG0v Mmn5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NUWxN|AoRjJ2M{W1NVMxRC:jPh?=
MCF7 NUHxO|hES3m2b4TvfIlkcXS7IHHzd4F6 NXz2VHAyPDhiaILz MlHVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{BmgHC{ZYPzbY5oKEiHUkKgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDD[YxtXGm2ZYKtS4xwKGG|c3H5MEBKSzVyIE2gNVUvPzlizszNMi=> NHO5VIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7 NWXvXI5VS3m2b4TvfIlkcXS7IHHzd4F6 M{[0blQ5KGi{cx?= MX3DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIV5eHKnc4PpcochUEWUMnTlcJRiOTZiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGOnbHygeoli[mmuaYT5JIFnfGW{IES4JIhzeyCFZXzsWIl1\XJvR3zvJIF{e2G7LDDJR|UxKD1iMUmuNlIh|ryPLh?= MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR|NUWxN|A9N2F-
MDA-MB-468 NYnyTmQ6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NWjNRmRiPzJiaILz MojXRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuPDZ6IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUAzOCEQvF2u NFXTT5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5Nlg3OCd-MkiwPVI5PjB:L3G+
HCC827 NYPTfJo2S3m2b4TvfIlkcXS7IHHzd4F6 MWC3NkBpenN? M{TlWGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhESzh{NzDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliY3HsZ4Vqdi2DTTDkfYUh[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5MEBIUTVyIE2gNlIvOyEQvF2u MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTB6OUK1PUc,OjlyOEmyOVk9N2F-
MDA-MB-468 NVy3dmFiSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUDoPZg{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBGT0[UIH;2[ZJmgHC{ZYPzbY5oKGi3bXHuJG1FSS2PQj20Olgh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hOjNwNE[g{txONg>? MnzxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3N{C4OFMoRjJzNUewPFQ{RC:jPh?=
HCT116 M4KyZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkXrRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hPDJwM{[g{txONg>? MofHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3N{C4OFMoRjJzNUewPFQ{RC:jPh?=
NCI-N87 NWrhemczSW62aYT1cY9zKGG|c3H5 M4Pn[mFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1PQDdiY3XscJMhgGWwb3fyZYZ1\WRiaX6gZZRpgW2rYzDtc5V{\SCjc4Pld5Nm\CCjczD0eY1weiCpcn;3eIghcW6qaXLpeIlwdiCjdDCyNEBu\y:tZzygdI8hWURiZn;yJFE1KGSjeYOgcYVie3W{ZXSgZYZ1\XJiMUmg[IF6ew>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFyMUGzNkc,OjJzMEGxN|I9N2F-
A431 NYrk[mFETnWwY4Tpc44h[XO|YYm= NEf2[oYxNjByMTD0c{AyOCC3TR?= MUGyJIhzew>? NXz0ZlRLUW6qaXLpeIlwdiCxZjDISXIyKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIHj1cYFvKEF2M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEWUS{GvNkBxcG:|cHjvdplt[XSrb36gZZQhOC5yMEGgeI8hOTBidV2gbY5kfWKjdHXkJIZweiB{IHjyd{BjgSCZZYP0[ZJvKGKub4SgcYV1cG:m M4jHOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N|MxLz5{NUOwOVM{ODxxYU6=
A431 MnT1SpVv[3Srb36gZZN{[Xl? M2Ho[lAvODBzIITvJFExKHWP MUKyJIhzew>? MU\Jcohq[mm2aX;uJI9nKEiHUkGgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hcHWvYX6gRVQ{OSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gRWtVKHCqb4PwbI9zgWyjdHnvckBifCByLkCwNUB1dyBzMDD1UUBqdmO3YnH0[YQh\m:{IEKgbJJ{KGK7IGfld5Rmem5iYnzveEBu\XSqb3S= M{DNWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N|MxLz5{NUOwOVM{ODxxYU6=
BT474 MV\GeY5kfGmxbjDhd5NigQ>? NHLBVWYxNjByMTD0c{AyOCC3TR?= M3rtdlIhcHK| MVjJcohq[mm2aX;uJI9nKEiHUkKgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hcHWvYX6gRnQ1PzRiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJGVTUzFxMjDwbI9{eGixconsZZRqd25iYYSgNE4xODFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAzKGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l MoW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MEWzN|AoRjJ3M{C1N|MxRC:jPh?=
BT474 NXXmUoZRTnWwY4Tpc44h[XO|YYm= Mn3yNE4xODFidH:gNVAhfU1? MmXiNkBpenN? NE\xSHlKdmirYnn0bY9vKG:oIFjFVlIhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iaIXtZY4hSlR2N{SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKEGNVDDwbI9{eGixconsZZRqd25iYYSgNE4xODFidH:gNVAhfU1iaX7jeYJifGWmIH\vdkAzKGi{czDifUBY\XO2ZYLuJIJtd3RibXX0bI9l NHK1bpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVM{OCd-MkWzNFU{OzB:L3G+
A431 NX3TdIVOTnWwY4Tpc44h[XO|YYm= MWiwMlAxOSC2bzCxNEB2VQ>? M{\IPFIhcHK| MkTVTY5pcWKrdHnvckBw\iCKRWKxJJBpd3OyaH;yfYxifGmxbjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBpfW2jbjDBOFMyKGOnbHzzJIF1KDBwMECxJJRwKDFyIIXNJIlv[3WkYYTl[EBnd3JiMjDodpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?= M1rWeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N|MxLz5{NUOwOVM{ODxxYU6=
BT474 NEK5ZZpHfW6ldHnvckBie3OjeR?= NVPQUnJ6OC5yMEGgeI8hOTBidV2= NFzxWnozKGi{cx?= M2jhWGlvcGmkaYTpc44hd2ZiSFXSNkBxcG:|cHjvdplt[XSrb36gLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hcHWvYX6gRnQ1PzRiY3XscJMh[XRiMD6wNFEhfG9iMUCgeW0hcW6ldXLheIVlKG[xcjCyJIhzeyCkeTDX[ZN1\XKwIHLsc5QhdWW2aH;k M1vYOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1N|MxLz5{NUOwOVM{ODxxYU6=
U-2 OS NEPaSlNyUFSVIHHzd4F6 NX:yRo5ueUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGWtNkBQWyClZXzsdy=> MkPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
A673 MWnxTHRUKGG|c3H5 NH;ze4tyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiQU[3N{Bk\Wyucx?= NH\ZVJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
A673 Mm\CdWhVWyCjc4PhfS=> MmWydWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKEF4N{OgZ4VtdHN? NIP5NWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
DAOY MVzxTHRUKGG|c3H5 M{j4RZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCGQV;ZJINmdGy| M1TWclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Saos-2 MWnxTHRUKGG|c3H5 MXfxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW2Gxcz2yJINmdGy| MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
BT-37 NH;QV3FyUFSVIHHzd4F6 M2\HdJFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCEVD2zO{Bk\Wyucx?= MlLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
BT-37 MVzxTHRUKGG|c3H5 NUXEcJJ3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFLUMVM4KGOnbHzz NHvKRoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
RD MYXxTHRUKGG|c3H5 Mn;tdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKGIHPlcIx{ M2TSS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
RD NWTLZ5RHeUiWUzDhd5NigQ>? MX\xTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWkRiY3XscJM> NWHrPHhpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
SK-N-SH NGLJ[m1yUFSVIHHzd4F6 M1O5VpFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMXNJKGOnbHzz MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
MG 63 (6-TG R) NVi2S49qeUiWUzDhd5NigQ>? NXPjN5ppeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF3HJFY{KCh4LWTHJHIqKGOnbHzz M13BWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
BT-12 NXT4eHlUeUiWUzDhd5NigQ>? MljsdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRnQuOTJiY3XscJM> MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
SK-N-SH MUXxTHRUKGG|c3H5 NUfY[HVweUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhW0tvTj3TTEBk\Wyucx?= NIrBUpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
A673 MoLrdWhVWyCjc4PhfS=> MnvXdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgRVY4OyClZXzsd{k> MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Rh30 NF\ITVRyUFSVIHHzd4F6 MofjdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog{OCClZXzsdy=> M13sRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
U-2 OS M4rhOJFJXFNiYYPzZZk> M4fkepFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJHUuOiCRUzDj[Yxtew>? M3zNd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh41 M1e5NJFJXFNiYYPzZZk> MlzjdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVog1OSClZXzsdy=> M37KRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SJ-GBM2 NIi4U5NyUFSVIHHzd4F6 MXHxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhW0pvR1LNNkBk\Wyucx?= M1nBZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC MljTdWhVWyCjc4PhfS=> NHHCVIVyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> MkXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SK-N-MC MW\xTHRUKGG|c3H5 NIrqXZFyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1OSyClZXzsdy=> M{DHXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NB-EBc1 NXnoeWxVeUiWUzDhd5NigQ>? NXjTUJJbeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CMWVD[zFiY3XscJM> MoDCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
LAN-5 NGLDbYhyUFSVIHHzd4F6 NWnHNo9peUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFzBUk02KGOnbHzz M2\4XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
Rh18 M3vHWpFJXFNiYYPzZZk> MYLxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhWmhzODDj[Yxtew>? NF7HWFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Rh18 M3fJT5FJXFNiYYPzZZk> Mlu2dWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohS2:wZnnycYF1d3K7IIPjdoVmdiCob4KgVogyQCClZXzsdy=> M3K1R|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
NCI-H522 MVPBcpRqfHWvb4KgZZN{[Xl? MlTJRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWg2OjJiY3XscJMhgGWwb3fyZYZ1\WRiaX6gRoFt[i:lIH71[IUhdW:3c3WgZZN{\XO|ZXSgZZMhfHWvb4Kg[5Jwf3SqIHnubIljcXSrb36gZZQhOTByIH3nM4toNCCrZzDh[I1qdmm|dHXy[YQhd26lZTDkZYltgSCob4KgNlgh\GG7czDy[YxifGm4ZTD0c{Bkd262cn;s NF;MNVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC5Nlg3OCd-MkiwPVI5PjB:L3G+
MCF7 NGX2XXJHfW6ldHnvckBie3OjeR?= M1\WUVExKHWP NWrNem5DOiCqcoO= NIfZTmFKdmirYnn0bY9vKG:oIFjFVlIh\GWudHGxOkBufXSjboSgZZV1d3Cqb4PwbI9zgWyjdHnvckBifCC\MUK0PEBqdiCqdX3hckBOS0Z5IHPlcIx{KGG2IEGwJJVOKGGodHXyJFIhcHK|IHL5JHdme3Sncn6gZoxwfHSrbne= M2j5eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{W1NVMxLz5{NEO1OVE{ODxxYU6=
MCF7 NVnCenhDTnWwY4Tpc44h[XO|YYm= MX[xNEB2VQ>? Mmi0NkBpenN? NFz3c4NKdmirYnn0bY9vKG:oIFjFVlIh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZNVI1QCCrbjDoeY1idiCPQ1[3JINmdGy|IHX4dJJme3OrbnegdINFVkF|IHH0JFExKHWPIHHmeIVzKDJiaILzJIJ6KFenc4Tldo4h[myxdITpcoc> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN3NUGzNEc,OjR|NUWxN|A9N2F-
MCF7 MnvvSpVv[3Srb36gZZN{[Xl? NUnRXGN7OTBidV2= M1jyblIhcHK| M{nBcmlvcGmkaYTpc44hd2ZiRVfGVkBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGmxNFY5KGmwIHj1cYFvKE2FRkegZ4VtdHNiZYjwdoV{e2mwZzDISXIz\GWudHGxOkBifCBzMDD1UUBi\nSncjCyJIhzeyCkeTDX[ZN1\XKwIHLsc5R1cW6p NUTFU5VRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVUyOzBpPkK0N|U2OTNyPD;hQi=>
MCF7 MYjGeY5kfGmxbjDhd5NigQ>? MXyxNEB2VQ>? NHS2bFgzKGi{cx?= NYDCdG5[UW6qaXLpeIlwdiCxZjDFS2ZTKGG3dH;wbI9{eGixconsZZRqd25iYYSgXVExPjhiaX6gbJVu[W5iTVPGO{Bk\WyuczDlfJBz\XO|aX7nJGhGWjJiYYSgNVAhfU1iYX\0[ZIhOiCqcoOgZpkhX2W|dHXyckBjdG:2dHnu[y=> NEfIdVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO1OVE{OCd-MkSzOVUyOzB:L3G+
MCF7 MXrGeY5kfGmxbjDhd5NigQ>? NV\iOXNCOTBidV2= MnyyNkBpenN? NGnXcnVKdmirYnn0bY9vKG:oIFXHSnIh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZNVA3QCCrbjDoeY1idiCPQ1[3JINmdGy|IHX4dJJme3OrbnegdINFVkF|IHH0JFExKHWPIHHmeIVzKDJiaILzJIJ6KFenc4Tldo4h[myxdITpcoc> NULEUFhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVUyOzBpPkK0N|U2OTNyPD;hQi=>
MCF7 NYjh[IxYTnWwY4Tpc44h[XO|YYm= M1PTPVExKHWP MX:yJIhzew>? NF;FbFVKdmirYnn0bY9vKG:oIFjFVlIh[XW2b4Doc5NxcG:{eXzheIlwdiCjdDDZNVI1QCCrbjDoeY1idiCPQ1[3JINmdGy|IHH0JFExKHWPIHHmeIVzKDJiaILzJIJ6KFenc4Tldo4h[myxdITpcoc> NVvIdmQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVUyOzBpPkK0N|U2OTNyPD;hQi=>
A549 NHznU5ZHfW6ldHnvckBie3OjeR?= NYfqNWpRPTBidV2= NFGxSYszKGi{cx?= NFXFfHBKdmirYnn0bY9vKG:oIFXHSnIheGixc4Doc5J6dGG2aX;uJIF1KFlzME[4JIlvKGi3bXHuJGE2PDliY3XscJMh[XRiNUCgeW0heHKnaX7jeYJifGWmIH\vdkAzKGi{czDmc4xtd3enZDDifUBGT0ZiaX7keYN1cW:wIH3lZZN2emWmIHHmeIVzKDFyIH3pcpMh[nliV3XzeIVzdiCkbH;0JI1mfGixZB?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ|OE[xOEc,Ojh{M{i2NVQ9N2F-
A549 MVXGeY5kfGmxbjDhd5NigQ>? NF3ySlA2OCC3TR?= M{X5WlIhcHK| MXPJcohq[mm2aX;uJI9nKEWJRmKgdIhwe3Cqb4L5cIF1cW:wIHH0JHR6eiC{ZYPp[JVmKGmwIHj1cYFvKEF3NEmgZ4VtdHNiYYSgOVAhfU1icILlbY5kfWKjdHXkJIZweiB{IHjyd{Bnd2yub4fl[EBjgSCHR1[gbY5lfWO2aX;uJI1m[XO3cnXkJIFnfGW{IEGwJI1qdnNiYomgW4V{fGW{bjDicI91KG2ndHjv[C=> NVi0[nlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyN|g3OTRpPkK4NlM5PjF2PD;hQi=>
LLC M4i4SmFvfGm2dX3vdkBie3OjeR?= NGHqVZdCdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBud3W|ZTDMUGMh[2WubIOgbY1xdGGwdHXkJIlvKGmwIFO1O2JNNzZibX;1d4Uh[XO|ZYPz[YQh[XNidIXtc5Ih\3Kxd4ToJIlvcGmkaYTpc44h[XRiMUCwJI1oN2upLDDwc{By\CCob4KgNVQh\GG7cx?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzF6N{i1Okc,OjdzOEe4OVY9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
ERBB2 / pERBB2 / p53 / Mdm2 / MdmX / pERK / Hsp70 ; 

PubMed: 29799521     


Downregulation of HSF1, mutp53, and Mdm2 in lapatinib-sensitive parental BT474, but not in lapatinib-resistant BT474R cells, treated with indicated lapatinib concentrations for 24 h.

pEGFR / EGFR / pAkt / Akt / pmTOR / mTOR / PARP / c-PARP ; 

PubMed: 28938602     


SKBR3 and 78617 cells were treated with lapatinib as in panel A, then the expression of phospho-ErbB2 (Tyr1221/1222), ErbB2, phospho-EGFR (Tyr1068), EGFR, phospho-Akt (Ser473), Akt, phospho-Erk1/2 (Thr202/Tyr204), Erk2, phospho-mTOR (Ser2448), and mTOR were analyzed using Western blotting. 

p-HER2 / HER2 / p-HER3 / HER3 / p-S6 / S6 / p-4EBP1; 

PubMed: 22853430     


A panel of HER2-amplified breast cancer cells were treated with 200nM lapatinib for up to 72 hours to detect the initial downregulation and subsequent upregulation of HER2-HER3 and downstream signaling. Immunoblots were performed using the indicated antibodies.

29799521 28938602 22853430
Immunofluorescence
LC3 ; 

PubMed: 26637440     


SKBR3 GFP-LC3 cells were cultured for 6 days and UACC893 GFP-LC3 cells were cultured for 7 days with 5 μM EZN3046 or EZN4150 .

Vimentin / E-cadherin; 

PubMed: 28243326     


Cells treated with lapatinib (5µM) increased the expression of E-cadherin and inhibited the expression of Vimentin by immunofluorescence. (Magnification: 1000×).

26637440 28243326
Growth inhibition assay
Cell viability (OE19); 

PubMed: 25350844     


Dose-response curves from escalated dose of lapatinib in the presence of 1 µM concentration of saracatinib. The calculated values of IC50 for lapatinib were following; 207.3 nM and 145 nM, respectively, after lapatinib alone and in the presence of saracatinib for parental OE19; >1,000 nM after lapatinib alone for LR2A and LR2B; 91.66 nM and 224.0 nM in the presence of saracatinib in LR2A and LR2B, respectively. Values were presented as relative cellular viability relative to vehicle-treated controls with the mean ± S.E. of quadruplicate from a representative experiment. The p values calculated by two-way ANOVA were <0.0001 comparing lapatinib alone with lapatinib plus saracatinib both in the LR2A and LR2B.

Cell viability (A431 cells); 

PubMed: 28243326     


The MTT assay was performed on the viability of A431 cells by lapatinib at different concentrations (0.1-50μM) and IC50 value was analyzed as indicated on the plot (t-test).

25350844 28243326
In vivo Oral administration of Lapatinib (~100 mg/kg) twice daily significantly inhibits the growth of BT474 and HN5 xenografts in a dose-dependent manner. [1]

Protocol

Kinase Assay:[1]
- Collapse

In vitro kinase assays:

The IC50 values for inhibition of enzyme activity are generated by measuring inhibition of phosphorylation of a peptide substrate. The intracellular kinase domains of EGFR and ErbB2 are purified from a baculovirus expression system. EGFR and ErbB2 reactions are performed in 96-well polystyrene round-bottomed plates in a final volume of 45 μL. Reaction mixtures contain 50 mM 4-morpholinepropanesulfonic acid (pH 7.5), 2 mM MnCl2, 10 μM ATP, 1 μCi of [γ33P] ATP/reaction, 50 μM Peptide A [Biotin-(amino hexonoic acid)-EEEEYFELVAKKK-CONH2], 1 mM dithiothreitol, and 1 μL of DMSO containing serial dilutions of Lapatinib beginning at 10 μM. The reaction is initiated by adding the indicated purified type-1 receptor intracellular domain. The amount of enzyme added is 1 pmol/reaction (20 nM). Reactions are terminated after 10 minutes at 23°C by adding 45 μL of 0.5% phosphoric acid in water. The terminated reaction mix (75 μL) is transferred to phosphocellulose filter plates. The plates are filtered and washed three times with 200 μL of 0.5% phosphoric acid. Scintillation cocktail (50 μL) is added to each well, and the assay is quantified by counting in a Packard Topcount. IC50 values are generated from 10-point dose-response curves.
Cell Research:[1]
- Collapse
  • Cell lines: HFF, MCF-7, T47D, A-431, HN5, BT474, N87, CaLu-3, HB4a, and HB4a c5.2 cells
  • Concentrations: Dissolved in DMSO, final concentrations ~100 μM
  • Incubation Time: 72 hours
  • Method: Cells are exposed to various concentrations of Lapatinib for 72 hours. Relative cell number is estimated using methylene blue staining. The absorbance at 620 nm is read in a Spectra microplate reader. Cell death and cell cycle analysis are assessed by propidium iodide staining and antibody detection of incorporated BrdUrd and staining with propidium iodide.
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: CD-1 nude female mice implanted s.c. with HN5 cells, and C.B-17 SCID female mice implanted s.c. with BT474 cells
  • Dosages: ~100 mg/kg
  • Administration: Orally twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (172.09 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 581.06
Formula

C29H26ClFN4O4S

CAS No. 231277-92-2
Storage powder
in solvent
Synonyms GSK572016, GW2016
Smiles CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04608409 Recruiting Drug: Lapatinib and Paclitaxel Ovarian Cancer Frederick R. Ueland M.D.|University of Kentucky November 16 2020 Phase 1
NCT03075995 Unknown status Other: hight-fat breakfast Breast Cancer Sun Yat-sen University April 12 2017 Not Applicable
NCT02338245 Completed Drug: ASLAN001|Drug: Lapatinib|Drug: Capecitabine Metastatic Breast Cancer Aslan Pharmaceuticals December 29 2014 Phase 2
NCT02294786 Terminated Drug: Lapatinib|Drug: Capecitabine|Drug: Octreotide Cancer Novartis Pharmaceuticals|Novartis December 17 2014 Phase 2
NCT02213042 Completed Drug: Lapatinib|Biological: Trastuzumab Neoplasms Breast Novartis Pharmaceuticals|Novartis October 24 2014 Phase 2
NCT02158507 Active not recruiting Drug: Combination of Veliparib + Lapatinib Metastatic Triple Negative Breast Cancer University of Alabama at Birmingham|Scariot Foundation|GlaxoSmithKline|AbbVie September 2014 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If I want to use this compound(S2111, Lapatinib) in tumor-bearing mice via injection, how could I prepare the solution?

  • Answer:

    For I.P. administration, the compound solution should be clear solution. S2111 Lapatinib can be dissolved in 2% DMSO/30% PEG 300/5% Tween 80/ddH2O at 10 mg/ml for clear solution.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

Related EGFR Products

Tags: buy Lapatinib (GW-572016) | Lapatinib (GW-572016) supplier | purchase Lapatinib (GW-572016) | Lapatinib (GW-572016) cost | Lapatinib (GW-572016) manufacturer | order Lapatinib (GW-572016) | Lapatinib (GW-572016) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID